text:
The authors state that they have no conflicts of interest.
Perspective: Cell–Cell Adhesion and Signaling Through Cadherins: Connecting Bone Cells in Their Microenvironment†
Article first published online: 1 DEC 2006
DOI: 10.1359/jbmr.060811
Copyright © 2006 ASBMR
Journal of Bone and Mineral Research
Volume 21, Issue 12, pages 1821–1827, December 2006
Additional Information
How to Cite
Mbalaviele, G., Shin, C. S. and Civitelli, R. (2006), Perspective: Cell–Cell Adhesion and Signaling Through Cadherins: Connecting Bone Cells in Their Microenvironment. J Bone Miner Res, 21: 1821–1827. doi: 10.1359/jbmr.060811
- †
Publication History
- Issue published online: 4 DEC 2009
- Article first published online: 1 DEC 2006
- Manuscript Accepted: 16 AUG 2006
- Manuscript Revised: 26 JUL 2006
- Manuscript Received: 15 MAY 2006
- Abstract
- Article
- References
- Cited By
- Top of page
- Acknowledgements
The organization of cells in tissues and organs is controlled by molecular programs that afford cells the ability to recognize their neighbors and the extracellular matrix. Cell—cell and cell—matrix contact and adhesion are mediated by four major groups of molecules: cadherins, immunoglobulin-like molecules, integrins, and selectins.(1 Adhesive interactions are essential in embryonic development, when cell specification and tissue differentiation are dependent on the ability of undifferentiated cells to aggregate and sort out in specific areas of the embryo.(2 Cell adhesion is also involved in a variety of other biologic processes, such as cell polarity, the immune response, the inflammatory process, division and death, tumor progression, and metastases.(3–5 The biologic importance of cell—cell adhesion in certain tissues and organs is underscored by the findings of mutations of cell adhesion molecules in different pathologic conditions, such as pemphigus vulgaris, leukocyte adhesion deficiency,(6 inflammatory bowel disease,(7 and congenital forms of hearing loss and retinal degeneration.(8 Increasing evidence shops that direct cell—cell interactions are also intimately involved in a variety of processes critical for bone development, starting from embryonic cartilage formation to adult bone remodeling. Previous reviews have focused on cell—cell interactions mediated by cell—cell adhesion and gap junctions in these processes.(9–11 This article focuses on the role of cadherins and their interplay with β-catenin signaling for the maintenance and differentiation of skeletal stem cells in the adult bone microenvironment.
- Top of page
- Acknowledgements
Cell—cell adhesion: cadherins and the adherens junction
Cadherins are single-chain integral membrane glycoproteins, which derive their name from their function in mediating calcium-dependent cell—cell adhesion. To date, −80 members of this large superfamily have been cloned, and it is now clear that many tissues express more than one cadherin.(1,12 Cadherins have a molecular mass of −120 kDa and are composed of a long extracellular domain, a single transmembrane domain, and a relatively small cytoplasmic C-terminal tail. Calcium-binding sites are located in the extracellular domain, which is composed of five repeats and confers the ability to bind to the same cadherin on neighboring cells. Based on structural differences, cadherins are classified as type I, which includes, among others, N-, E-, M- and R-cadherin; and type II, comprising cadherin-5 through −12. Another group of cadherins includes those lacking the intracellular tail (i.e., T-cadherin and cadherin-13), whose function is still obscure. This now large family of molecules is sometimes referred to as "classical" cadherins to distinguish them from protocadherins, cadherin-related neuronal receptor, and other structurally related molecules present primarily in the central nervous system.(12
Assembly of the adhesion structure begins with cadherin homodimerization and stabilization of the five extracellular domains into a rigid X-shaped structure, a Ca2+-dependent process (Fig. 1). Such cis-dimers can dock to opposing cadherin dimers through trans-interactions through the first extracellular domain, leading to the formation of a "zipper"-like structure.(13,14 The cytoplasmic tail, highly conserved among cadherins, is important for stabilization of the adhesion structure, which occurs by cadherin lateral clustering and linkage to the cytoskeleton. Such organization is orchestrated by cadherin binding to β-catenin and plakoglobin, which link cadherin molecules to the actin cytoskeleton through α-catenin and other intermediate proteins, including actinin, vinculin, and ZO-1.(15,16 Very recent data indicate that this multiplex structure may not be as rigid as one would think, because α-catenin binding to either the cadherin/β-catenin complex or to actin is not simultaneous,(17 implying that the connection between the adhesion structure and the cytoskeleton is dynamic rather than static.(18 Regulation of adhesion is also controlled by cadherin binding to other proteins, most importantly p120ctn, which is structurally similar to β-catenin and is thought to stabilize cadherin-β-catenin binding.(19,20 The assembly of cadherins and their associated cytoskeletal elements form the junctional structures known as adherens junctions,(2,21 which provide anchorage between two adjoining cells.
Signaling: convergence of Wnt, β-catenin, and cadherin pathways
Among the proteins that stabilize the adherens junction, β-catenin has a particularly important role because of its involvement in the Wnt signaling system and its central role in osteogenic differentiation.(22–24 Canonical Wnt signaling results in β-catenin binding to members of the T cell factor/lymphoid enhancer factor (Tcf/Lef) family to regulate gene transcription. In the absence of Wnt signaling, cytoplasmic β-catenin is targeted for degradation through the ubiquitin/proteasome pathway by both casein kinase I and glycogen synthase kinase-3β (GSK-3β)—mediated serine/threonine phosphorylation.(25,26 Because β-catenin participates in both cell—cell adhesion and Wnt signaling, it represents a mechanism by which cadherins may modulate signaling.(16,27 By keeping β-catenin bound on adhesion structures on the cell surface, cadherins sequester β-catenin from its transcriptionally active pools,(28,29 thus potentially attenuating Wnt signaling.(30 In contrast, reduced abundance of cadherins on the cell surface can in theory make more β-catenin available for transcriptional regulation. At the same time, lower cadherin abundance destabilizes the adhesion complex, with loss of cell—cell adhesion and increased cell movement. The opposite occurs when cadherin—β-catenin binding is stabilized (Fig. 2). Thus, Wnt signaling induces conformational changes of β-catenin that favor assembly into transcriptional complexes, whereas β-catenin association with α-catenin favors cadherin binding and adhesion.(31,32
This model of cadherin/Wnt signaling interactions is widely accepted, but functional alternatives may exist. For example, β-catenin on the cell surface might serve as a reservoir for rapid recruitment of this signaling molecule into transcriptionally active pools in response to continuous Wnt signaling activation. In this scenario, a lower abundance of membrane-bound β-catenin might actually attenuate signaling because less β-catenin is available for mobilization into active pools on Wnt activation. In any case, intersection of cadherin-mediated adhesion and Wnt signaling through β-catenin offers a complex but flexible mechanism of cell regulation,(16,27,33 a mechanism of particular importance in the skeleton.
- Top of page
- Acknowledgements
Cadherins in bone mass acquisition
A number of in vitro studies have shown that cells of the osteoblastic lineage express two major cadherins, N-cadherin (Cdh2) and cadherin-11 (Cdh11) and that disrupting cadherin function using adhesion inhibiting peptides,(34,35 function blocking antibodies,(36 antisense RNA,(37 or overexpression of dominant negative mutants,(35,38 consistently impairs osteoblast differentiation. More recently, new in vivo genetic models have provided more direct evidence of the biological role of cadherins in skeletal development and bone remodeling. Unfortunately, homozygous Cdh2 null mutation is embryonically lethal(39; however, mice genetically deficient of Cdh11 display minor calcification defects of the cranial sutures and become osteopenic by 3 months of age, an abnormality seen primarily in the trabecular bone and linked to a cell autonomous functional defect of bone-forming cells.(40 The relatively mild phenotype of these animals may be explained by partial redundancy between Cdh2 and Cdh11. Whereas tissue-specific Cdh2 ablation models are being developed, a recent study elegantly showed that ex vivo limb bud cultures from Cdh2 null embryos partially rescued by transgenic expression of E-cadherin were able to undergo cartilage condensation and develop into structured limbs in the absence of Cdh2.(41 Thus, either N-cadherin is dispensable for cartilage development or caderin-11 compensates for lack of N-cadherin. Preliminary results from our group suggest that the latter may be the case. Compound Cdh2 heterozygous/Cdh11 null mice develop a smaller skeleton with thinner cortices of long bones and much more severe osteopenia than single Cdh11 null mice.(42 Intriguingly, these animals exhibit both an osteogenic differentiation defect'consistent with loss of Cdh11(40'and a decrease in the number of colony forming units-fibroblast (CFU-F), suggesting that N-cadherin may be involved in maintaining bone marrow skeletal stem cell (SSC) niches.(42
In an attempt to overcome the partial redundancy of osteoblast cadherins, we developed a transgenic mouse model expressing a dominant negative N-cadherin mutant (NcadΔC) in osteoblasts in vivo using the mouse osteocalcin (Og2) promoter.(43 Because this mutant lacks almost entirely the extracellular domain, it is unable to dimerize and consequently, it disrupts cell—cell adhesion.(44,45 However, because NcadΔC retains the intracellular domain, it may have a sequestering effect on β-catenin when expressed at sufficiently high levels.(11 We found that Og2-NcadΔC mice exhibit a marked delay in the acquisition of peak bone mass, the result of impaired osteogenic differentiation.(43 Interestingly, there was a concomitant increase in percent body fat in these transgenic mice relative to their wildtype littermates, suggesting a shift from osteogenesis to adipogenesis. In fact, the number of adipogenic precursors isolated from bone marrow cells of Og2-NcadΔC mice was higher and the number of osteogenic precursors was lower relative to wildtype cells. Importantly, whereas cell—cell adhesion among osteoblasts was modestly decreased by expression of the dominant negative N-cadherin mutant, β-catenin nuclear localization was notably decreased, with a corresponding increase in membrane localization.(43 Thus, not only does NcadΔC disrupt cell—cell adhesion but it also sequesters β-catenin on the cell surface, and this correlates with a significant decrease of Tcf/Lef-dependent transcriptional activity.(46 That the osteogenic to adipogenic shift in Og2-NcadΔC transgenic mice was at least in part consequent to reduced β-catenin was shown by the rescue, in vitro, of this abnormality by expression of an active β-catenin mutant.(43 Obviously, these results do not exclude that interference with cell—cell adhesion might also be responsible for the osteogenic defect in these mice. Nonetheless, the phenotype of these transgenic mice provides the first in vivo evidence that osteoblast cadherins are involved in bone marrow stromal cell lineage allocation and supports the notion that cadherins influence Wnt/β-catenin signaling in regulating cell differentiation and function.
These new in vivo data can be used to update the "cadherin switch" model of SSC lineage allocation that we(9,47 and others(48 had proposed earlier based on in vitro observations. As shown in Fig. 3, bone marrow stromal cells express a relatively wide repertoire of cadherins, including Cdh2, Cdh11, and R-cadherin, although at low abundance.(47,48 N-cadherin may serve a major role in maintaining SSC in their undifferentiated state, perhaps controlling their self-renewal (i.e., the capacity of dividing giving rise to two daughter cells with the same multipotential capacity as the mother cells [symmetric division] or to a daughter cell that remains a stem cell and another that is committed [asymmetric division]).(49 Evidence for this role of N-cadherin in SSC maintenance is still circumstantial or indirect but very suggestive. Not only is N-cadherin relatively abundant compared with other cadherins in undifferentiated cells,(47,48 but overexpression of Cdh2 prevents full chondrocyte differentiation, even though it favors cell aggregation in micromass cultures.(50,51 Although embryonic chondrogenesis is obviously a different process than osteoblast differentiation in adult bone marrow, these observations suggest that N-cadherin may have a "braking" effect on mesenchymal cell differentiation. Such a conclusion is consistent with our unpublished data indicating that mice heterozygous for Cdh2 null mutation have reduced osteoprogenitors in the bone marrow, despite faster mineralization of calvaria cells. As discussed more in depth later, data from the hematopoietic field also support a role of N-cadherin in regulating stem cell self-renewal. Commitment to osteogenesis is associated with upregulation of Cdh11,(47,52,53 whereas downregulation of Cdh11 (and Cdh2) favors adipogenesis (Fig. 3). Thus, the presence of both N-cadherin and cadherin-11 defines osteogenic commitment. As osteoblast differentiation progresses, Cdh2 is progressively downregulated, and Cdh11 remains as the major osteoblast cadherin. The molecular mechanisms by which cadherins modulate this process are the object of current research. Certainly, cadherins do provide the adhesion structures for cell—cell aggregation and perhaps for guiding migration of committed cells to the areas of active bone remodeling. However, maintaining "appropriate" levels of intracellular β-catenin might well be another mechanism by which cadherins modulate SSC lineage allocation.
Heterotypic and "orthotypic" cell—cell interactions in bone
The notion that direct cell—cell contact between osteoclast precursors and cells of the stromal/osteoblastic lineage are necessary for induction of osteoclast differentiation has been known to bone biologists for over a decade.(54 We now know that this heterotypic cell—cell interaction is functionally mediated by engagement of RANK with RANKL.(55,56 Importantly, both receptor, RANK, and ligand, RANKL, are membrane bound molecules present in osteoclast precursors and osteoblastic cells, respectively. Thus, close proximity between the two interacting cells is required for initiation and maintenance of the osteoclastogenic signal, but it is unlikely that this interaction alone provides a strong cell—cell anchorage that would allow stable RANK—RANKL engagement and initiation of osteoclastogenic signaling. In fact, earlier work convincingly showed (even before the discovery of RANKL) that osteoclastogenesis could be prevented by inhibiting cadherin-dependent heterotypic (osteoblast/stromal cells—osteoclast precursors) interactions.(57,58 Cadherin-6 was found to be involved in this mechanism, and expression of a dominant negative, adhesion defective cadherin-6 mutant prevented stromal cell support of osteoclastogenesis.(58 More recent data suggest that cadherins expressed by osteogenic cells can also control the expression of RANKL through a β-catenin—dependent mechanism.(46 Considering that E-cadherin may be involved in osteoclast precursor fusion,(57 interference with cadherin-mediated cell—cell interactions becomes a reasonable target for inhibition of osteoclast differentiation.
Two breakthrough studies from two independent investigative teams have generalized the relevance of heterotypic osteoblast/stromal-osteoclast/hematopoietic interactions through cadherins, elegantly showing that osteoblasts are critical in maintaining the hematopoietic stem cell (HSC) niche(59 and that stimulation of osteogenic activity by either expression of a constitutively active PTH/PTH-related peptide (PTHrP) receptor mutant in osteoblasts or by exogenous administration of PTH increases the number of HSCs.(60 In this case, modulation of HSCs was attributed to modulation of Notch signaling, again, a system based on membrane-bound ligand and receptors, thus requiring cell—cell contact for optimal ligand presentation to the receptor. This heterotypic contact is maintained, at least in part, by N-cadherin,(61 because HSCs are located in close proximity to cells lying on the bone surface and both cell types express Cdh2 and β-catenin in vivo.(59 Furthermore, Cdh2 is necessary to maintain stem cells in Drosophila.(62 The role of N-cadherin in HSC niche maintenance has been further supported by the recent demonstration that the balance between HSC self-renewal and differentiation is controlled by c-Myc in a N-cadherin—dependent fashion.(63 Increased c-Myc expression decreases N-cadherin abundance, thus allowing HSCs to escape from the niche and undergo differentiation, whereas loss of c-Myc leads to increased N-cadherin and HSC accumulation into the niche.(63 These results reinforce the idea that N-cadherin contributes to maintain cells in an undifferentiated state but its persistence prevents differentiation. As noted earlier, such notion is consistent with the demonstration that overexpression of Cdh2 prevents progression from precartilage condensation to chondrocyte development, probably by stabilizing cell—cell adhesion or increasing the threshold for Wnt signaling.(51,64 In this new scenario, the concept of osteoblast/stromal cell support of osteoclastogenesis becomes a particular case of a more general mechanism of osteoblast—hematopoietic cell interactions, in which cadherins play a prominent role.
These studies and the results from our dominant negative cadherin transgenic mice suggest that osteoblast control of stem cell niches may also extend to the stromal compartment. As just mentioned, mice overexpressing a constitutively active PTH/PTHrP receptor have increased HSC number.(60 However, in the first few months of life, they also exhibit a major delay in development of a bone marrow cavity because of exuberant bone formation. Later, with continuous bone remodeling, hematopoietic supportive stroma develops, although with a decreased number of SSC.(65 This finding was attributed to a depletion of SSC as a consequence of multiple rounds of bone turnover. Because the promoter used in that model, a 2.3-kb fragment of αI(I) collagen, is expressed strongly only in cells that are already committed to osteogenesis, another possible interpretation is that osteogenic cells modulate the survival and fate of their own precursors, as they do with hematopoietic precursors. Such a mechanism would be consistent with our own data showing an osteogenesis to adipogenesis shift in bone marrow precursors of Og2-NcadΔC transgenic mice.(43 Because in these animals the transgene is only expressed in differentiated osteoblasts, it is reasonable to believe that the lineage allocation defect is mediated by cadherin modulation of cell—cell interactions between differentiated osteoblasts and undifferentiated stromal cells through regulation of cell—cell adhesion and/or β-catenin signaling. We propose this type of cell—cell interaction be called "orthotypic," to distinguish between osteoblast—osteoblast (homotypic) and osteoblast—hematopoietic cells (heterotypic), because the interaction is between cells of the same lineage but of different phenotypic features.
Model of cadherin modulation of SSC commitment and bone cell differentiation
The data reviewed herein can be interpreted and summarized in a model that defines cadherins' role in bone cell differentiation (Fig. 4). As noted, Cdh2 is expressed at higher levels than any other cadherins in bone marrow stromal cells(47,48 and serves to keep these cells in an undifferentiated state, allowing aggregation in a niche, an organization similar to HSC niches.(61,66 In fact, SSC and HSC may even co-exist in the same microanatomical niches.(67 Extending the proposed mechanism by which N-cadherin serves as mediator of heterotypic interactions between osteoblasts and HSC,(61,63 differentiated osteoblasts also support the SSC niche through N-cadherin (and cadherin-11?)— mediated cell—cell adhesion (orthotypic interactions; Fig. 4, left). Close proximity between osteoblastic cells and SSC may allow engagement of membrane bound ligand-receptor systems (e.g., Notch signaling), which modulate SSC self-renewal and fate. Alternatively, modulation of SSC may occur through indirect, perhaps β-catenin—dependent paracrine mechanisms, and production of extracellular factors that feed back onto SSC. SSC lineage allocation (escape from the niche) requires loss of cell—cell adhesion attended by downregulation of Cdh2 and increased β-catenin signaling. As osteoblast differentiation progresses, cadherin-11 provides the main mechanism of homotypic (among osteoblasts) cell—cell interactions. In an analogous fashion, direct contact between osteoblastic cells and osteoclast precursors (probably mediated by cadherin-6) facilitates RANK—RANKL engagement and osteoclastogenesis (Fig. 4, right).
By providing means of direct interactions among cells of different lineages and by modulating β-catenin signaling, cadherins represent fundamental players for stem cell specification and osteoblast differentiation and function. Future work will focus on the mechanisms by which cadherin mediated adhesion and modulation of β-catenin signaling drive bone modeling and remodeling. As we unlock these mechanisms, the potential for development of new therapeutic targets aimed at increasing one's potential for osteogenesis may become apparent.
- Top of page
- Acknowledgements
This study was supported by National Institute of Arthritis and Musculoskeletal and Skin Diseases Grant AR43470 (to RC).
- Top of page
- Acknowledgements
- 11996 Cell adhesion: The molecular basis of tissue architecture and morphogenesis. Cell 84: 345–357.
- 22005 Regulation of cadherin-mediated adhesion in morphogenesis. Nat Rev Mol Cell Biol 6: 622–634.
- 31999 p27 is involved in N-cadherin-mediated contact inhibition of cell growth and S-phase entry. Oncogene 18: 869–876., , ,
- 41999 N-cadherin-mediated human granulosa cell adhesion prevents apoptosis: A role in follicular atresia and luteolysis? Am J Pathol 154: 1391–1406., , , , , ,
- 52003 The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: From the laboratory to clinical practice. Ann Oncol 14: 1705–1713., ,
- 61999 Structure and function of cell adhesion molecules. Am J Med 106: 467–476., ,
- 72004 Cadherins: An integral role in inflammatory bowel disease and mucosal restitution. J Gastroenterol 39: 413–421., ,
- 82004 Genetic heterogeneity in Usher syndrome. Am J Med Genet A 130: 13–16.,
- 92002 Intercellular junctions and cell-cell communication in bone BilezikianJP, RodanAR, RaiszLG (eds.) Principles of Bone Biology, 2nd ed. Academic Press, San Diego, CA, USA, 287–302., , ,
- 102005 Cell-to-cell interactions in bone. Biochem Biophys Res Commun 328: 721–727.,
- 112005 Cell-cell interactions in regulating osteogenesis and osteoblast function. Birth Defects Res C 75: 72–80.,
- 122000 Cadherin superfamily genes: Functions, genomic organization, and neurologic diversity. Genes Dev 14: 1169–1180.,
- 131999 Cadherins and their connections: Adhesion junctions have broader functions. Curr Opin Cell Biol 11: 554–560.,
- 141999 Mechanism of cell-cell adhesion complex assembly. Curr Opin Cell Biol 11: 561–566.
- 152001 New aspects of Wnt signaling pathways in higher vertebrates. Curr Opin Genet Dev 11: 547–553.,
- 162004 Convergence of Wnt, beta-catenin, and cadherin pathways. Science 303: 1483–1487.,
- 172005 Deconstructing the cadherin-catenin-actin complex. Cell 123: 889–901., , , ,
- 182005 Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell 123: 903–915., , , ,
- 191999 The armadillo family of structural proteins. Int Rev Cytol 186: 179–224.
- 202004 Regulation of cadherin stability and turnover by p120ctn: Implications in disease and cancer. Semin Cell Dev Biol 15: 657–663.,
- 212005 The differential adhesion hypothesis: A direct evaluation. Dev Biol 278: 255–263.,
- 222005 Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev Cell 8: 739–750., , ,
- 232005 Canonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell 8: 751–764., , , , , , , , , ,
- 242005 Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development 132: 49–60., , , , ,
- 252002 The Wnt signalling pathway. J Cell Sci 115: 3977–3978.,
- 262002 Casein kinase 1: A Wnt'er of disconnect. Curr Biol 12: R499–R501.
- 272001 Adhesion signaling: How beta-catenin interacts with its partners. Curr Biol 11: R792–R794.,
- 281996 Binding to cadherins antagonizes the signaling activity of β-catenin during axis formation in Xenopus. J Cell Biol 132: 1105–1114., , ,
- 291998 Inhibition of β-catenin-mediated transactivation by cadherin derivatives. Proc Natl Acad Sci USA 95: 15339–15344., , , ,
- 302001 FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak. Dev Cell 1: 37–49.,
- 312004 Distinct molecular forms of β-catenin are targeted to adhesive or transcriptional complexes. J Cell Biol 167: 339–349.,
- 322004 Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions. Genes Dev 18: 2225–2230., , , , ,
- 332003 Cellular signaling in developmental chondrogenesis: N-cadherin, Wnts, and BMP-2. J Bone Joint Surg Am 85(Suppl 2): 137–141.
- 341998 Human osteoblasts express a repertoire of cadherins, which are critical for BMP-2-induced osteogenic differentiation. J Bone Miner Res 13: 633–644., , , , , , , ,
- 352000 A role for N-cadherin in the development of the differentiated osteoblastic phenotype. J Bone Miner Res 15: 198–208., , , , , , , , , ,
- 362000 N- and E-cadherin mediate early human calvaria osteoblast differentiation promoted by bone morphogenetic protein-2. J Cell Physiol 183: 117–128., , , , ,
- 371998 The Ser252Trp FGFR-2 mutation in Apert syndrome selectively increases E-cadherin and N-cadherin expression in human calvaria osteoblasts in vitro and in vivo. Bone 23: S188., , , , ,
- 382000 A dominant-negative cadherin inhibits osteoblast differentiation. J Bone Miner Res 15: 2362–2370., , ,
- 391997 Developmental defects in mouse embryos lacking N-cadherin. Dev Biol 181: 64–78., , , , ,
- 402001 Targeted disruption of cadherin-11 leads to a reduction in bone density in calvaria and long bone metaphyses. J Bone Miner Res 16: 1265–1271., , , , , , , , ,
- 412004 N-cadherin is not essential for limb mesenchymal morphogenesis. Dev Dyn 232: 336–344., ,
- 422005 Severely reduced bone mass with defective osteoblastogenesis in N-cadherin heterozygous/cadherin-11 null double mutant mice. J Bone Miner Res 20: S17., , ,
- 432004 Targeted expression of a dominant-negative N-cadherin in vivo delays peak bone mass and increases adipogenesis. J Cell Sci 117: 2853–2864., , , , , , ,
- 441995 Delayed assembly of desmosomes in keratinocytes with disrupted classic-cadherin-mediated cell adhesion by a dominant negative mutant. J Invest Dermatol 104: 27–32., , , , , , ,
- 451993 Disruption of epithelial cell-cell adhesion by exogenous expression of a mutated nonfunctional N-cadherin. Mol Biol Cell 4: 37–47.,
- 462005 Dominant negative N-cadherin inhibits osteoclast differentiation by interfering with β-catenin regulation of RANKL, independent of cell-cell adhesion. J Bone Miner Res 20: 2200–2212., , , , , , , , , , ,
- 472000 Relative abundance of different cadherins defines differentiation of mesenchymal precursors into osteogenic, myogenic, or adipogenic pathways. J Cell Biochem 78: 566–577., , , , ,
- 482001 The transition of cadherin expression in osteoblast differentiation from mesenchymal cells: Consistent expression of cadherin-11 in osteoblast lineage. J Bone Miner Res 16: 260–269., , , ,
- 492000 Out of Eden: Stem cells and their niches. Science 287: 1427–1430.,
- 502002 Analysis of N-cadherin function in limb mesenchymal chondrogenesis in vitro. Dev Dyn 225: 195–204.,
- 512003 Retinoic acid inhibits chondrogenesis of mesenchymal cells by sustaining expression of N-cadherin and its associated proteins. J Cell Biochem 89: 837–847., , , ,
- 521999 Expression and function of the splice variant of the human cadherin-11 gene in subordination to intact cadherin-11. J Bone Miner Res 14: 764–775., , , , ,
- 532004 Cell-cell interaction mediated by cadherin-11 directly regulates the differentiation of mesenchymal cells into the cells of the osteo-lineage and the chondro-lineage. J Bone Miner Res 19: 1840–1849., , , ,
- 541988 Osteoblastic cells are involved in osteoclast formation. Endocrinology 123: 2600–2603., , , , , , ,
- 551997 Osteoprotegerin: A novel secreted protein involved in the regulation of bone density. Cell 89: 309–319., , , , , , , , , , , , , , , , , , , , , , , ,
- 561999 Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci USA 96: 3540–3545., , , , , , , , , , , , , , , , , , , ,
- 571995 The role of cadherin in the generation of multinucleated osteoclasts from mononuclear precursors in murine marrow. J Clin Invest 95: 2757–2765., , , ,
- 581998 Cadherin-6 mediates the heterotypic interactions between the hemopoietic osteoclast cell lineage and stromal cells in a murine model of osteoclast differentiation. J Cell Biol 141: 1467–1476., , , , , , , , ,
- 592003 Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425: 836–841., , , , , , , , , , , , ,
- 602003 Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425: 841–846., , , , , , , , , , , ,
- 612004 A new bone to pick: Osteoblasts and the haematopoietic stem-cell niche. Bioessays 26: 595–599.,
- 622002 DE-cadherin-mediated cell adhesion is essential for maintaining somatic stem cells in the Drosophila ovary. Proc Natl Acad Sci USA 99: 14813–14818.,
- 632004 c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. Genes Dev 18: 2747–2763., , , , , , , , ,
- 642002 Alterations in the spatiotemporal expression pattern and function of N-cadherin inhibit cellular condensation and chondrogenesis of limb mesenchymal cells in vitro. J Cell Biochem 87: 342–359.,
- 652004 The interplay of osteogenesis and hematopoiesis: Expression of a constitutively active PTH/PTHrP receptor in osteogenic cells perturbs the establishment of hematopoiesis in bone and of skeletal stem cells in the bone marrow. J Cell Biol 167: 1113–1122., , , , , , , , ,
- 662005 Non-hematopoietic bone marrow stem cells: Molecular control of expansion and differentiation. Exp Cell Res 306: 330–335., ,
- 672004 Adult mesenchymal stem cells: Characterization, differentiation, and application in cell and gene therapy. J Cell Mol Med 8: 301–316., ,


text:
|By PR Newswire
Article Rating:
|May 17, 2013 09:30 AM EDT
CHICAGO, May 17, 2013 /PRNewswire/ -- Zacks.com announces the list of stocks featured in the Analyst Blog. Every day the Zacks Equity Research analysts discuss the latest news and events impacting stocks and the financial markets. Stocks recently featured in the blog include DTS Inc (Nasdaq:DTSI), Avis Budget Group Inc. (Nasdaq:CAR), JTH Holding, Inc. (Nasdaq:TAX), United Rentals Inc. (NYSE:URI) and Hertz Global Holdings Inc. (NYSE:HTZ).
(Logo: http://photos.prnewswire.com/prnh/20101027/ZIRLOGO)
Get the most recent insight from Zacks Equity Research with the free Profit from the Pros newsletter: http://at.zacks.com/?id=5513
Here are highlights from Thursday's Analyst Blog:
DTS Upgraded to Strong Buy
On May 14, 2013, Zacks Investment Research upgraded DTS Inc (Nasdaq:DTSI) to a Zacks Rank #1 (Strong Buy). With a strong return of 30.5% over the past six months and a positive estimate revision trend, DTS is an attractive investment opportunity.
Why the Upgrade?DTS reported a better-than-expected first quarter of 2013, with non-GAAP earnings (including stock-based compensation) of 7 cents, much better than the Zacks Consensus Estimate of a loss of 7 cents per share.
Revenues for the quarter increased 21.7% on a year-over-year basis to $32.7 million. However, revenues were slightly below the Zacks Consensus Estimate of $33.0 million.
Operating profit (excluding amortization & acquisition cost but including stock-based compensation) decreased to $3.9 million from $7.6 million in the previous-year quarter, primarily due to higher operating expenses.
The earnings beat helped DTS to reiterate its revenue guidance range of $140 million-$146 million for 2013. DTS continues to expect non-GAAP operating margin in the low to mid-20s and non-GAAP earnings in the range of $1.05 to $1.20 per share.
DTS expects revenues from the Blu-ray segment to be approximately 25% of total revenue due to the impact of the new game console cycle. However, DTS expects flat to marginal growth in standalone players and a decline in Blu-ray-enabled PCs.
Moreover, DTS hinted that the primary growth driver in 2013 will be the network connected business (TV and mobile devices).
Avis Expands Zipcar Services
Zipcar Inc., a wholly-owned subsidiary of global vehicle rental giant, Avis Budget Group Inc. (Nasdaq:CAR), yesterday announced the expansion of its car sharing services in the City of Lakes, Minneapolis. This implies that Zipcar's services will be now available in 21 major metropolitan cities.
Though the company has its presence in the city since 2005, its services were available only to the students and staff of University of Minnesota, and in other nearby vicinities. However, the recent development will provide ample opportunities to Minneapolis inhabitants to avail Zipcar's all-purpose car sharing services. The company will charge its members $8.75 on an hourly basis or $72.00 for 24 hours.
Currently, this Avis Budget subsidiary intends to commence its operations in the city by positioning 40 vehicles at the most suitable locations including Dinkytown, Downtown, Loring Park, Northeast, North Loop and Seven Corners. Additionally, the company is in talks with City of Minneapolis officials to set up on-street parking spots. It also intends to expand its operations in other major areas of the city as well as in St. Paul.
Avis Budget, which competes with JTH Holding, Inc. (Nasdaq:TAX), acquired Zipcar in Jan 2013 for a total value of $500 million. Following the completion of acquisition, Avis Budget has been aggressively expanding Zipcar's services at various new locations. Earlier this month, Avis Budget expanded Zipcar's airport services in the North American continent by starting its operations at 8 new locations.
In the United States alone, car sharing is currently a lucrative business worth nearly $400 million and is rapidly advancing in other parts of the world. With over 760,000 members, Zipcar enjoys presence in 21 major cities of the U.S., Canada and Europe.
We believe that the acquisition of Zipcar has facilitated Avis Budget to extend its offerings from car rental to car sharing, and has helped it compete better with rivals such as United Rentals Inc. (NYSE:URI) and Hertz Global Holdings Inc. (NYSE:HTZ). The latter has its own car sharing service, Hertz On Demand.
Avis Budget, which currently carries a Zacks Rank #2 (Buy), expects the acquisition to generate an annual synergy of $50–70 million. Zipcar is engaged in operating a car sharing network and providing self-service vehicles to members located in reserved parking spaces throughout the neighborhoods where they live and work. The company's vehicles are available for use through its reservation system accessible by phone, the Internet or wireless mobile devices.
Want more from Zacks Equity Research? Subscribe to the free Profit from the Pros newsletter: http://at.zacks.com/?id=5515.
About Zacks Equity Research
Zacks Equity Research provides the best of quantitative and qualitative analysis to help investors know what stocks to buy and which to sell for the long-term.
Continuous coverage is provided for a universe of 1,150 publicly traded stocks. Our analysts are organized by industry which gives them keen insights to developments that affect company profits and stock performance. Recommendations and target prices are six-month time horizons.
Zacks "Profit from the Pros" e-mail newsletter provides highlights of the latest analysis from Zacks Equity Research. Subscribe to this free newsletter today: http://at.zacks.com/?id=5517
About Zacks
Zacks.com is a property of Zacks Investment Research, Inc., which was formed in 1978 by Leon Zacks. As a PhD from MIT Len knew he could find patterns in stock market data that would lead to superior investment results. Amongst his many accomplishments was the formation of his proprietary stock picking system; the Zacks Rank, which continues to outperform the market by nearly a 3 to 1 margin. The best way to unlock the profitable stock recommendations and market insights of Zacks Investment Research is through our free daily email newsletter; Profit from the Pros. In short, it's your steady flow of Profitable ideas GUARANTEED to be worth your time! Register for your free subscription to Profit from the Pros at http://at.zacks.com/?id=5518.
Visit http://www.zacks.com/performance for information about the performance numbers displayed in this press release.
Follow us on Twitter: http://twitter.com/zacksresearch
Join us on Facebook: http://www.facebook.com/home.php#/pages/Zacks-Investment-Research/57553657748?ref=ts
Disclaimer: Past performance does not guarantee future results. Investors should always research companies and securities before making any investments. Nothing herein should be construed as an offer or solicitation to buy or sell any security.
Media Contact
Zacks Investment Research
800-767-3771 ext. 9339
SOURCE Zacks Investment Research, Inc.
As enterprises around the world struggle with their digital transformation efforts, many are finding that innovative digital teams are moving much faster than their hidebound IT organizations. Rather than struggling to convince traditional IT to get with the digital program, executives are taking advice from IT research firm Gartner, and encouraging existing IT to continue in their desultory ways. However, many CIOs are realizing the dangers of following Gartner's advice. The central challenge ...
May. 6, 2016 02:42 PM EDT
Unless you don't use the internet, don't live in California, or haven't been paying attention to the recent news… you should be aware that self-driving cars are on their way to becoming a reality. I have seen them – they are real. If you believe in the future reality of self-driving cars, then continue reading on. If you don't believe in the future possibilities, then I am not sure what to do to convince you other than discuss the very real changes that will roll out with the consumer producti...
May. 6, 2016 02:15 PM EDT Reads: 907
Cloud Object Storage is effectively infinitely scalable and boasts the lowest total costs. But cloud SLAs and T&Cs are traditionally optimized for huge customers like Netflix, so applications demanding better confidentiality or higher availability typically can't reap the benefits of public cloud storage. In his session at 18th Cloud Expo, Don Martin, CTO of Security First Corp, will provide an overview of innovative technologies available today – secret sharing and information dispersal algori...
May. 6, 2016 02:02 PM EDT Reads: 143
There is an ever-growing explosion of new devices that are connected to the Internet using "cloud" solutions. This rapid growth is creating a massive new demand for efficient access to data. And it's not just about connecting to that data anymore. This new demand is bringing new issues and challenges and it is important for companies to scale for the coming growth. And with that scaling comes the need for greater security, gathering and data analysis, storage, connectivity and, of course, the...
May. 6, 2016 01:45 PM EDT Reads: 1,366
Cloud-based NCLC (No-code/low code) application builder platforms empower everyone in the organization to quickly build applications and executable processes that broaden access, deepen collaboration, and enhance transparency for all team members. Line of business owners (LOBO) and operations managers know best their part of the business and their processes. IT departments are beginning to leverage NCLC platforms to empower and enable LOBOs to lead the innovation, transform the organization, an...
May. 6, 2016 01:04 PM EDT Reads: 207
The IETF draft standard for M2M certificates is a security solution specifically designed for the demanding needs of IoT/M2M applications. In his session at @ThingsExpo, Brian Romansky, VP of Strategic Technology at TrustPoint Innovation, will explain how M2M certificates can efficiently enable confidentiality, integrity, and authenticity on highly constrained devices.
May. 6, 2016 01:00 PM EDT Reads: 1,405
In the world of DevOps there are 'known good practices' – aka 'patterns' – and 'known bad practices' – aka 'anti-patterns.' Many of these patterns and anti-patterns have been developed from real world experience, especially by the early adopters of DevOps theory; but many are more feasible in theory than in practice, especially for more recent entrants to the DevOps scene. In this power panel at @DevOpsSummit at 18th Cloud Expo, moderated by DevOps Conference Chair Andi Mann, panelists will dis...
May. 6, 2016 12:45 PM EDT Reads: 1,185
See storage differently! Storage performance problems have only gotten worse and harder to solve as applications have become largely virtualized and moved to a cloud-based infrastructure. Storage performance in a virtualized environment is not just about IOPS, it is about how well that potential performance is guaranteed to individual VMs for these apps as the number of VMs keep going up real time. In his session at 18th Cloud Expo, Dhiraj Sehgal, in product and marketing at Tintri, will discu...
May. 6, 2016 12:30 PM EDT Reads: 1,210
trust and privacy in their ecosystem. Assurance and protection of device identity, secure data encryption and authentication are the key security challenges organizations are trying to address when integrating IoT devices. This holds true for IoT applications in a wide range of industries, for example, healthcare, consumer devices, and manufacturing. In his session at @ThingsExpo, Lancen LaChance, vice president of product management, IoT solutions at GlobalSign, will teach IoT developers how t...
May. 6, 2016 12:00 PM EDT Reads: 836
The pace of innovation, vendor lock-in, production sustainability, cost-effectiveness, and managing risk… In his session at 18th Cloud Expo, Dan Choquette, Founder of RackN, will discuss how CIOs are challenged finding the balance of finding the right tools, technology and operational model that serves the business the best. He will discuss how clouds, open source software and infrastructure solutions have benefits but also drawbacks and how workload and operational portability between vendors...
May. 6, 2016 11:57 AM EDT Reads: 247
When it comes to IoT in the enterprise, namely the commercial building and hospitality markets, a benefit not getting the attention it deserves is energy efficiency, and IoT's direct impact on a cleaner, greener environment when installed in smart buildings. Until now clean technology was offered piecemeal and led with point solutions that require significant systems integration to orchestrate and deploy. There didn't exist a 'top down' approach that can manage and monitor the way a Smart Buildi...
May. 6, 2016 10:53 AM EDT Reads: 197
So, you bought into the current machine learning craze and went on to collect millions/billions of records from this promising new data source. Now, what do you do with them? Too often, the abundance of data quickly turns into an abundance of problems. How do you extract that "magic essence" from your data without falling into the common pitfalls? In her session at @ThingsExpo, Natalia Ponomareva, Software Engineer at Google, will provide tips on how to be successful in large scale machine lear...
May. 6, 2016 10:30 AM EDT Reads: 1,597
You think you know what's in your data. But do you? Most organizations are now aware of the business intelligence represented by their data. Data science stands to take this to a level you never thought of – literally. The techniques of data science, when used with the capabilities of Big Data technologies, can make connections you had not yet imagined, helping you discover new insights and ask new questions of your data. In his session at @ThingsExpo, Sarbjit Sarkaria, data science team lead ...
May. 6, 2016 10:00 AM EDT Reads: 1,319
SYS-CON Events announced today that Peak 10, Inc., a national IT infrastructure and cloud services provider, will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. Peak 10 provides reliable, tailored data center and network services, cloud and managed services. Its solutions are designed to scale and adapt to customers' changing business needs, enabling them to lower costs, improve performance and focus inter...
May. 6, 2016 10:00 AM EDT Reads: 1,528
Digital payments using wearable devices such as smart watches, fitness trackers, and payment wristbands are an increasing area of focus for industry participants, and consumer acceptance from early trials and deployments has encouraged some of the biggest names in technology and banking to continue their push to drive growth in this nascent market. Wearable payment systems may utilize near field communication (NFC), radio frequency identification (RFID), or quick response (QR) codes and barcodes...
May. 6, 2016 10:00 AM EDT Reads: 1,107

subset: commoncrawl


text:
Party, Craft & School Supplies
Brainy Toys for Kids of All Ages
Get Free Shipping + $10 Off Orders $49 or more Refer Now
Your cart is currently empty.
Items remain in your shopping cart for 30 days.
Save up to 65% off Shop
Up to 60% Off Wedding Supplies Shop
Save Up to 50% Off! Ends April 6 Shop
Hersheys as low as 9¢ per piece! Shop
Ranger Stickles™ Patriotic Glitter Glue Set. Give your patriotic crafts some sparkle with this glitter glue set. Includes .5-oz. bottles of glitter glue. Non-settling and easy flow tip. Safe and non-toxic. (8 pcs. per unit) Conforms to ASTM D-4236.
1 Set(s)


text:
To access the full Church Times online archive please log in above with your Church Times user email & password
Posted: 02 Nov 2006 @ 00:00
Weidenfeld & Nicolson, £20 (£18); 0-297-84409-1
Let the waters flow: an Israeli company called Netafim, based in Tel Aviv,
pioneered the concept of drip irrigation, which is now used all around the
world. The picture (right) shows their ceremonial laying of drip-irrigation
lines at a project in Asia. In little more than a half-century, says the book,
the beneficial results of Israel's creative energy are being felt worldwide, in
disciplines that range from technology and medicine to the arts
To order this book email the details to
Church Times
The Bishop of St Albans with the Patrons wish to appoint
a Team Rector Designate
We seek someone who will
work in partnership with a Team Vicar
Designate (who they will help ...
Read More
Thu 5 May 16 @ 18:30In tomorrow's Church Times: healing, #ThyKingdomCome and the machine gun preacher: https://t.co/VDInRPaqvk https://t.co/q0b9KYiMkW
Thu 5 May 16 @ 10:48RT @cadmanhomesGREAT to see our little venture featured on the front cover with the article on pages 15 & 17 of Church Times! https://t.co/1qNyi2YiYB


text:
SmartScore 99
SmartScore 99
SmartScore 86
SmartScore 92
Here's the question you clicked on:
Which of the following functions is not a sinusoid? y = sin x y= Sqrtx y = cos x None of the above are sinusoids.
definitely \[\sqrt x\] is not a sinusoid , it doesn't vary as a sine wave or a cosine wave
thats what i was thinkging thanks!!
btw does a sinusoid have to go below the x axis??
no, sinusoid wave are those which show a smooth repetitive variation or oscillation , like a sine wave or a cosine wave , it doesn't have to go below x axis, if you shift the origin up with respect to the original origin you wont have it below x axis, its just a general trend
|dw:1369863941221:dw| O new is the new origin
I would say yes (it has to go below), since I take as definition that a sinusoid is a function of the form \(\lambda \sin(\alpha x + \phi)\), with \(\lambda, \alpha, \phi\in\mathbb R\). But you allow a vertical translation in your definition the answer is yes..
how bout this then??
you have to find in your definition in your course. (wikipedia says that the general form allows for a vertical shift). If your definition is the general definition, then there are two sinusoid curves on this picture.
y= sqrt of x


text:
Producer Marc Platt is partnering with Stories International, Inc., the production arm and joint venture of renowned video game brand SEGA Group and Hakuhodo DY Group, to develop and produce the film adaptation of SEGA's iconic video game franchise, "Shinobi." Platt and Adam Siegel will produce through the Marc Platt PRoduction banner alongside STORIES President… Read more »
Prince Music Piracy Jumps More Than Tenfold After Artist's Death
Internet pirates went crazy downloading Prince songs the week following the legendary musician's death. From April 21-28, a total of 230,031 users were accessing the Purple One's hits like "When Doves Cry," "I Would Die 4 U" and "Let's Go Crazy" on file-sharing services, according to piracy-tracking firm Excipio. That's more than ten times the… Read more »
NBC Brings Olympics Coverage to Snapchat, With A Little Help From Buzzfeed
Olympians, get your snaps ready: The NBC Sports Group's Olympics division has partnered with Snapchat to cover the 2016 Rio Olympics with live stories and a new Discover channel. NBC will produce the Olympics Discover channel in conjunction with Buzzfeed, and make it available to Snapchat users for roughly two weeks during the games, which… Read more »
Marc Platt To Bring Sega's 'Shinobi' To Big Screen
Is this the next big franchise? Producer Marc Platt has partnered with video game maker Sega to develop and produce a feature film based on its video game franchise Shinobi. He and his production company will work with Sega and Hakuhodo DY Group's production arm and joint venture Stories International, Inc. on the property.
Shinobi is a series of video games that has been around since 1987 so it is well-known among gamers. Shinobi means "ninja" in Japanese. It is a…
Read more at http://deadline.com/
Tony DiSanto's DIGA Ups Tommy Coriale To General Manager, Sets 'Jerky Boys', Neil Strauss, Jay Sankey, Traci Stumpf Shows
Tommy Coriale has been promoted to General Manager of DIGA, reporting to the production company's co-founder and CEO Tony DiSanto. The new role expands Coriale's current responsibilities as VP of Production to include oversight of business development and growth of the company. Additionally, the company has set up a development slate that includes unscripted projects featuring the Jerky Boys from the popular comedy prank calls, author Neil Strauss, magician Jay Sankey…
Read more at http://deadline.com/
Tony Awards Eligibility: 'Shuffle Along' Deemed a New Musical
"Shuffle Along" has been deemed a new musical in the upcoming Tony Awards race — thereby putting the freshly opened show, from a formidable team of creators and performers, in direct competition with "Hamilton." The decision was issued by the Tony Awards Administration Committee in its final meeting of the season, during which the group… Read more »
Oscar-Winning Cinematographer Robert Richardson Inks With WME
EXCLUSIVE: WME has signed three-time Academy Award-winning cinematographer Robert Richardson, whose most recent credit is Quentin Tarantino's Cinemascope Western The Hateful Eight, which earned him his ninth Oscar nomination. He just wrapped production on Ben Affleck's Live By Night for Appian Way and Warner Bros.
Richardson won Oscars for Oliver Stone's JFK and Martin Scorsese's The Aviator and Hugo. His credits include Stone's Platoon and Born On The Fourth Of July…
Read more at http://deadline.com/
'Star Wars: Episode VIII' New Photos Show Off Ship, Vintage Helmet
Director Rian Johnson offered a few breadcrumbs to appease hungry fans until the next update on "Star Wars: Episode VIII." Johnson took to his "lousy stinkin" Tumblr to share some big news with "Star Wars" fans. "I can't believe we're halfway through the shoot. (We're halfway through the shoot!)" He also released some set photos showing… Read more »
VB&P and Reebok want you to take advantage of all 25,915 days.
The average human lifespan is 71 years. That's 25,915 days. And that's the premise for this new Reebok spot from Venables Bell & Partners. It's a nice spot and concept – although everyone knows you don't run from bears. That'll cut your lifespan down by a lot.
Dowsing – "Red Legs Kicking" Video
Dowsing have shared a video for "Red Legs Kicking," a track off the Chicago-based emo crew's third full-length, which comes out to day. The clip, which was directed by Kenna Hynes, features the band in an abandoned high school and takes on a slasher-movie urgency as it goes on. Watch below. [videoembed size="full_width" … More »


text:
Irwin Record Stillson Wrench 300 Series
A popular pipe wrench with three essential load bearing components - handle, hook jaws and adjusting nuts.
About fwb
Meeting the demands of the most challenging industries.
Don't miss out! Grab yourself a bargain while stocks last!
fwb Product Guide
For quick reference time and again!


text:
Foursquare © 2016 Lovingly made in NYC & SF
Coffee Shop · $$
Jl. Pantai Indah Utara 2, The Gallery Blok 8
"Greentea latte"
BLOWFISH Kitchen & Bar
Sushi · $$
City Plaza at Wisma Mulia (Jalan Jenderal Gatot Subroto Kav. 42)
"Nice place to have some fun. Great music & ambiance!"
Restaurant · $$
Level 1, Shangri-La Hotel, Jl. Jend. Sudirman Kav. 1
"Try their rum ice cream and cream brulee!"
Make sure your information is up to date. Plus use our free tools to find new customers.
Download Foursquare for your smart phone and start exploring the world around you!


text:
Thank you so very much. I am happy to say that I'm so happy I found your web site. I will tell all my friends and family about you. Thank you again.
More Testimonials »
Color Wands
From $4.52
Colored Pencils
From $2.45
Washable Classic Markers
From $3.69
Watercolor Sets
From $2.09


text:
Law & Order: Special Victims Unit 1999 | TV Show Watchlist
Season 13, Episode 17 Justice Denied
First Aired: April 11, 2012
A closed rape case of Benson's is reopened because of its similarities to a new case, and the possibility of wrongful imprisonment surfaces. As Benson's work is questioned, tension develops between her, ADA Haden and Bayard Ellis.
Guest Cast
Mark Consuelos Matt Martinez
Harry Connick Jr. ADA David Haden
Andre Braugher Bayard Ellis
Next On TVSee all »
Sat Apr 30 6:00pm
BeefSeason 11, Episode 20 IONI'll Watch171 Watching
Cast & Details See all »
- Premiered: September 20, 1999
- Rating: TV-14
- Premise: Sexual assaults, domestic disputes and kidnappings are often the primary focus of this crime show, which follows New York City detectives working in a specialized division within the police department. The first spin-off of "Law & Order," this series has f… (more)
Trending TonightSee all »
Outlander9:00 pm | STARZI'll Watch195 Watching
NBA Playoff: Game 1: Thunder at Spurs8:30 pm | TNTI'll Watch78 Watching
Jazz at the White House
Jazz at the White House8:00 pm | ABCI'll Watch78 Watching
Popular Shows
Popular Movies
Popular Celebrities
- 1. Melissa Benoist
- 2. Leonardo DiCaprio
- 3. Gal Gadot
- 4. Jeffrey Dean Morgan
- 5. Ben Affleck
- 6. Jennifer Lawrence
- 7. Shemar Moore


text:
Exclusive: The Club - Downtown dash
Here's Tariq again, making you all look rubbish. Tom reckons he's this good, but we doubt it. He's all words and no weaponry that boy.
Comments (3)
Tom Clancy's The Division guide Our essential guide to Ubi's loot-stuffed shooter.
Dark Souls 3 guide UPDATED: Boss fights, bonfires and plenty more besides.
Loading... hold tight!


text:
Coming up in the next {{countdown}} {{countdownlbl}}
Coming up next:
Skip to this video now
Now Playing:
Play Video
This transcript has been automatically generated and may not be 100% accurate.
Classmate Calls School Stabbing Suspect 'Misunderstood'
Alex Hribal had a "disturbing twist about him," student says.
Multiple Injuries in Stabbing Spree
Multiple injuries reported after a stabbing incident in Murrysville, Pa.
Now Playing: High School Stabbing Shocks Community
Now Playing: Pilot Escapes From Burning Plane After Crashing Into Tree
Now Playing: Vatican Hosts Stem Cell Research Conference
Now Playing: Prescription Drugs Found at Prince's Home, Police Say
Now Playing: New Evidence in Mystery of Boys Lost at Sea
Now Playing: Tornadoes Strike From California to Kentucky
Now Playing: Ted Cruz Drafts Carly Fiorina as His Running Mate
Now Playing: Will Carly Fiorina Help Ted Cruz Stop Donald Trump?
Now Playing: Edward Snowden Responds to 'Snowden' Movie Trailer
Now Playing: Jessica Alba's Honest Company Now Under Fire for Organic Baby Formula
Now Playing: TJ Holmes Marries Couple During the 'GMA' Wide World of Weddings
Now Playing: Family on a Mission to Find a Cure for Daughter's Rare Genetic Disease
Now Playing: 'GMA' 24-Hour Wedding Marathon Kicks Off
Now Playing: New Report Says Spanking May Be Linked to Lifelong Social, Mental Health Problems in Kids
Now Playing: Stars Reunite for 'Thelma & Louise' 25th Anniversary
Now Playing: Birds, Lightning Strike Flights
Now Playing: Man's Live-Tweets of Hockey Game Goes Viral
Now Playing: Three Couples Tie the Knot in Bustling Times Square
Now Playing: Couple's Intimate Scottish Wedding Features Romantic Traditions
Now Playing: {{itm.title}}


text:
2010 Review: Micah Lidberg
Micah wrote about (and illustrated) a giant forest rat for our latest publication. He is consistently presenting (in mind-bending detail) a world we'd much prefer to live in. We'd be terrified of talent like this if it weren't for the fact that he's also absolutely ace.
Micah's image of the year: "If 2010 was anything for me, it felt like a year of transition. This was the state of my new studio the day after I moved in."
Mark out of 10 for 2010?
I would give 2010 a solid 8. For how good it was it seemed like an incredibly quick year. It came and went as if it were late for something. I had loads of new and novel experiences and I turned a quarter-century old. I like the number 25.
What broke? How did you fix it?
I accidentally broke my connection to the outside world. An illustrator's studio is good for that. It has been said it's not good for man to be alone. I agree. My fix was to move half way across the country.
What was the best thing you saw this year?
The best sight was flying into New York City at dusk. LaGuardia Airport is my least favorite New York airport, however, the views flying in and out of it are spectacular.
What was your favourite day of the year?
I had too many perfect days to count. I lived on a beach for two thirds of the year, spent quite a bit of time in New York, and recently moved back to my beloved hometown. Each location has offered plenty of days that would qualify for a favourite.
Most dangerous/scariest moment?
I drove a fifteen-foot moving truck a little over a thousand miles by myself… at night.
Best Google image search of 2010?
Best man/woman of the year?
Jennifer Sims of Hugo & Marie. She is relentlessly productive and her advice is magical.
Your finest moment?
Arriving with myself and the moving truck fully intact and operational after the thousand mile drive.
If you could only take one thing that you bought in 2010 into 2011, what would it be?
Practical: My computer. Impractical: My elkhorn fern.
What would you like to say to 2010?
It was fun hanging out. You were good company. Though, I'm kind of bummed Jupiter didn't turn into a star.
- How I Got Here: Marco Velardi and Omar Sosa, Apartamento magazine
- It's Nice That x Channel 4 Random Acts: "It'll be like a guided acid trip"
- Felicity Hammond's art sends up the visual language of luxury property developers
- Gillian Wearing uses the public's work to examine privacy and individual vs collective experience
- Anna Biel defies convention with "trashy" illustrations and animations
- Polish illustrator Gosia Herba interprets myths and legends in pastel tones
- Don't Hug Me I'm Scared - an exclusive interview with Duck, Red Guy and Yellow Guy
- Yoshinori Mizutani captures the colourful, rain soaked commuters of Tokyo
- Poem Baker photographs the Jûngølā drag clowns of London's Deptford
- Stack founder Steven Watson shares five of his top magazines
- Photography: New show at LCC shows young travelling communities of the 90s
- Hilarious and charming new Maynards Bassetts' Liquorice Allsorts ad by Jack Sachs


text:
83-17300 - Raspberry Pi™ 3 Model B 1GB Project Board
It's here! The Raspberry Pi 3 Model B is the latest generation of single-board computers from the Raspberry Pi Foundation. Upgrades include a faster 1.2GHz ARMv8 64bit processor and built-in WiFi and Bluetooth functionality.
Mfr Name: Raspberry Pi
Mfr Number: RASPBERRYPI-MODB-1GB
See all items in Boards and Bundles
72-935 - Compact A-Weighted Sound Level Meter
Compact Digital Sound Level Meter
Ultra compact sound level meter is perfect for numerous types of measurement including sound system testing and noise level monitoring.
Mfr Name: Tenma
Mfr Number: 72-935
See all items in Sound Level Meters
72-1020 - 40,000 Count 4-1/2 Digit True RMS Benchtop Multimeter DMM
True RMS Benchtop Digital Multimeter
Ideal for the service bench or lab where high accuracy is important. This unit measures AC/DC voltage and current, resistance, capacitance, frequency, and temperature. It also provides diode and audible continuity test, as wel...
Mfr Number: 72-1020
See all items in Benchtop
72-7770 - 1999 Count Manual Ranging Multimeter with Square Wave Output
Compact meter that features a wide range of measurement capabilities, and is ergonomically designed to easily fit in the palm of your hand. 3-1/2 digit, 1999 count display measures AC/DC voltage, DC current, ohms and diode check.
Mfr Number: 72-7770
See all items in Handheld
83-17219 - LISIPAROI IR LED Camera Light for Raspberry Pi
Using your Raspberry Pi camera module in a dark setting? Look no further, this IR LED board is here to brighten your day.
Mfr Name: Cyntech
Mfr Number: LISIPAROIIR-01
See all items in Single Board Computers
82-20655 - Outdoor HD 720p TVI Varifocal Day/Night Dome Turret Camera
Outdoor HD 720p TVI Varifocal Day/Night Dome Camera
This compact HD-TVI 720p turret dome camera design is easy to mount and features EXIR technology to make the most of your IR LEDs. It also features a 2.8~12mm varifocal lens, night vision up to 164ft, and an IP6...
Mfr Name: Hikvision USA
Mfr Number: DS-2CE56C5T-VFIT3
See all items in Dome Cameras
82-20560 - 4-Channel Embedded Plug and Play NVR
4-Channel Embedded Plug and Play NVR
Record video and audio from up to 4 cameras with Hikvision's 4-Channel NVR, offering plug-and-play PoE interfaces and capable of being used as a standalone recorder, or as part of a comprehensive surveillance system. Main feat...
Mfr Number: DS-7604NI-E1/4P
See all items in 4 Channel DVRs and NVRs
82-20570 - 16-Channel Embedded Plug and Play NVR
16-Channel Embedded Plug and Play NVR
Record video and audio from up to 16 cameras with Hikvision's 16-Channel NVR, offering plug-and-play PoE interfaces and capable of being used standalone or as part of a comprehensive surveillance system. Main features include...
Mfr Number: DS-7616NI-E2/16P
See all items in 16 Channel DVRs and NVRs
310-0702 - Lulzbot Taz 5 3D Printer
The LulzBot TAZ 5 is a versatile, high performance desktop 3D printer with a massive 11.7in x 10.8in x 9.8in build area. It arrives ready to use out of the box and since it's Open Source, it can be modified and expanded as you see fit.
Mfr Name: MCM
Mfr Number: KT-PR0036NA
See all items in 3D Printing
82-20650 - Outdoor HD 720p TVI Varifocal Day/Night Bullet Camera
Outdoor HD 720p TVI Varifocal Day/Night Bullet Camera
Excellent general purpose varifocal HD-TVI camera for day/night surveillance, this 720p bullet camera features a 1/3" CMOS high definition color image sensor and 2.8~12mm varifocal lens for amazing video clari...
Mfr Number: DS-2CE16C5T-VFIR3
See all items in Bullet Cameras
83-16561RK - Raspberry Pi™ 3 Model B Starter Kit
Looking for the essentials to get started with the new Raspberry Pi 3 Model B? This kit includes the new Raspberry Pi 3, a translucent case, a 16GB microSD card loaded with the NOOBS operating system, and a 5.25VDC 2.4A power supply to get you up and running in a ...
Mfr Number: 83-16561RK
83-17375 - T3 External 500GB USB Solid State Drive
500GB Samsung T3 External SSD Drive
Portability is the key element shared among all digital devices today where everything, including you, is constantly moving. When you are always on-the-go, your data should be, too. Born and bred with potent portability in its ...
Mfr Name: Crucial Memory
Mfr Number: MU-PT500B/AM
See all items in Solid State
83-17374 - T3 External 250GB USB Solid State Drive
250GB Samsung T3 External SSD Drive
Portability is the key element shared among all digital devices today where everything, including you, is constantly moving. When you are always on-the-go, your data should be, too. Born and bred with potent portability in its ...
Mfr Number: MU-PT250B/AM
72-8150 - Capacitance Meter
Capacitance Meter
Quickly and accurately measure capacitance values up to 20mF (20,000µF), in nine ranges, and resistance to 2,000MΩ in nine ranges.
Mfr Number: 72-8150
See all items in Capacitance / LCR Meters
72-7226 - Compact True RMS Clamp Meter
Compact True RMS Clamp Meter
Perfect for general purpose applications, this compact clamp meter measures AC/DC voltage, AC/DC current, resistance, frequency and duty cycle.
Mfr Number: 72-7226
See all items in Clamp Meters
Always quite happy with MCM.


text:
Farscape 1999 | TV Show Watchlist
Series Creator Confirms Farscape Movie Is in the Works
Apr 21, 2014 7:26 PM EDT
Ask Matt: The Middle, Big Bang Theory, Burn Notice, Fringe, and More
Dec 17, 2012 9:02 AM EST
Exclusive First Look: Doctor Who Trailer for "A Town Called Mercy"
Sep 8, 2012 10:00 PM EDT
Amy Pond Gets Trigger-Happy in Doctor Who Teaser Trailer
Mar 26, 2012 7:32 PM EDT
Ask Matt: Rescue Me, Doctor Who, Mad Men, LOLA and More!
Aug 2, 2010 10:50 AM EDT
Farscape Stars Browder and Black Keeping Busy
Jul 26, 2007 4:26 PM EDT
Exclusive: Farscape Producer Talks About the Franchise's Future
Jul 24, 2007 7:05 PM EDT
Farscape Lives, and Sci Fi's Other Awesomes Plans
Jul 16, 2007 2:18 PM EDT
Richard Dean Anderson Marks SG-1's 200th
Aug 18, 2006 4:00 AM EDT
Cast & Details See all »
- Premiered: March 19, 1999
- Rating: TV-PG
- Premise: Cult favorite about an astronaut stranded light years from Earth in an alien war zone and his adventures with a group of extraterrestrial fugitives on the lam from an evil collective. A handsome production design, complex characters and imaginative plot tw… (more)
Trending TonightSee all »
Blindspot10:01 pm | NBCI'll Watch852 Watching
Gotham8:00 pm | FOXI'll Watch696 Watching
Jane the Virgin9:00 pm | CWI'll Watch481 Watching
Farscape: Season 2, 15th Anniversary Edition
By New Video GroupBuy New: $13.99
Investigating Farscape: Uncharted Territories of Sex and Science Fiction
By I. B. TaurisBuy New: $27.00
Farscape: The Complete Series
By A&E EntertainmentBuy New: $114.99
Popular Shows
Popular Movies
Popular Celebrities
- 1. Melissa Benoist
- 2. Leonardo DiCaprio
- 3. Gal Gadot
- 4. Jeffrey Dean Morgan
- 5. Ben Affleck
- 6. Jennifer Lawrence
- 7. Shemar Moore


text:
Can a legal victory make Indian Country whole again?
For over a century, federal law has split Native American land holdings into tiny pieces. A settlement unites some of the splinters, but at a steep cost.by Sierra Crane-Murdoch, Apr 04, 2016
The darkness at the heart of Malheur
A Westerner traces the roots – and meaning – of the Oregon occupationby Hal Herring, Mar 21, 2016
Protecting the Oregon Trail from the development it helped create
Dedicated volunteers fight to preserve one of the trails that brought settlers west.by Sarah Gilman, Mar 07, 2016
Tracing America's borderlands history along the Anza Trail
Immigrants still follow Juan Bautista de Anza's historic route.by Sarah Tory, Mar 07, 2016
The fractured terrain of oil and gas opposition
In one of the West's biggest arguments, the battle lines are complicated and opaque.by Patty Limerick, Feb 22, 2016
Colorado activists set their sights on a ballot measure to limit drilling
Previous attempts have been blocked and current regulations disappoint.by Joshua Zaffos, Feb 22, 2016
Graphic: The hidden connections of the Sagebrush Insurgency
Where a sprawling network of actors find common cause.by Jonathan Thompson and Brooke Warren, Feb 02, 2016
The BLM's arms race on the range
The agency has armed up since 1978, but it's still outgunned without local backup.by Marshall Swearingen, Feb 02, 2016
The rise of the Sagebrush Sheriffs
How rural 'constitutional' peace officers are joining the war against the feds.by Jonathan Thompson, Feb 02, 2016
Sugar Pine Mine, the other standoff
How a small-time mining dispute in Oregon readied a network of militias for the Malheur occupation.by Tay Wiles, Feb 02, 2016
Wildlife Services and its eternal war on predators
The federal agency has been researching nonlethal means to protect livestock for decades. So why is it still killing so many carnivores?by Ben Goldfarb, Jan 25, 2016
Forty years of Sagebrush Rebellion
The Oregon occupation, the 2014 Bundy standoff and many other stories are all related to a long-simmering movement.by High Country News, Jan 04, 2016
New clues to the past in Nevada's desert fossils
Scientific inquiry is a process of constant revision. And revision is where the most intriguing discoveries happen.by Hillary Rosner, Dec 21, 2015
Why being a good neighbor is a good idea
Researchers look to Southwestern ranchers to learn why we share — and what happens when we don't.by Brian Mockenhaupt, Dec 07, 2015
Could Los Angeles design its way to water independence?
A pair of architects are reinvisioning the city's relationship with water, starting with storm runoff.by Sarah Tory, Nov 23, 2015
- jay weston on National Park Week fails to change the game
- Ben DeJarnette on A millennial mayor and his timber town
- Pam Roylance on Photos: Inside the controversial sport of coyote coursing
- Ed Morrow on Thousands of fish die in Colorado, amid flood recovery projects
- Richard Jones on National Park Week fails to change the game


text:
True. But close. Todays Iran is no longer Persia. Iranians are the Persians who were converted to Islam by the...Arabs. What else is there for Mostafa to claim "superiority" over arabs ? 1) 8 yrs of war with arab Iraq. Saddam's Iraq won on points. Millions of dead on Iran side. 1/10 of that on Iraq side. Arab Iraqi air force with Arab Saudi money controlling the skies over Iran. 2) being the pipeline to the world from the opium/heroin drug trade golden route, from Afghanistan into Pakistan and then into eastern Iran. 3) trying harder than any other major oil exporting country to have its oil and gas fall permanently into the hands of foreign powers. 4) Iran does not own the holy sites of Islam like some other "arab country", ergo: attack on Iran is not like "attack on Islam" ! Lastly, beware of the new Greeks in their flying ships to the west and to the east. They may also fly in from the north, if you get them really excited. And from the south.
Hello user Logout | profile
You have watched of 10 articles
Report: Russia withdraws 30 aircraft from Syria (Reuters)
from the article: Itamar and the centrifuges in Natanz


text:
Orlando Sentinel- Orlando news, sports and more, Orlando Sentinel
Thu, 06/25/2009 - 10:09am
Wopular is an
online newspaper rack,
giving you a summary view of the top headlines from the top news sites.
Senh Duong (Founder)Wopular,
All address information, particularly arrests, reflect police records.
PEABODY — Four people were injured in a two-vehicle accident Thursday when one car struck a house at 23 Clement Ave., according to police.
Item Photo by Owen O'Rourke Nahant Town Clerk Margaret Barile tests the voting machine that will be used in this Saturday's election. NAHANT — Nahant residents are getting ready for an all-day government affair.
Item Photo by Owen O'Rourke Swampscott's young poet laureate Camryn Cotter. SWAMPSCOTT — It'll be poetry in motion when the town's newest poets laureate read their original verse at Town Meeting on May 16.
Item Photo by Owen O'Rourke Derianna DiRico was the first speaker at the 4th annual Autism Awareness assembly at Lynn Classical. LYNN — Conner Robertson , a senior at Classical High School , has 10 siblings.
Plus: What were those confusing signs on El Camino Real on Monday?


text:
Join FREE | Login
+ Celebrations
+ How-To
+ Deals
Tangy Asian Chicken and Coleslaw Rolls
Cookies and Crescent Sweet Rolls
Garden Party Turkey Sandwiches
Caramel Sticky Buns
Petite Caramel Pecan Rolls
Macaroon-Cinnamon Roll Braid
32% fewer calories • 50% less sat fat than the original recipe. A warm, sweet, and cinnamony fresh-baked treat—in 30 minutes!
© 2016 ®/TM General Mills All Rights Reserved


text:
New board members for Rochester hospital
Rochester and Elmore District Health Service board has two new members, Carol McKinstry and Michelle O'Sullivan.GRAHAM WILLIS July 29, 2014 3:24am
The appointment of two new board members at Rochester and Elmore District Health Service has been welcomed by chief executive Anne McEvoy.
Dr Carol McKinstry and Michelle O'Sullivan will take their seats on the board, replacing retiring members Professor Jane Farmer and district resident David Gilbert.
Keith Oberin has accepted a further three-year term on the board.
Ms McEvoy thanked both retiring members for their contribution to the health service.
She was delighted with the new appointments and said both candidates brought great expertise to the board table.
''They have both local and professional connections to the organisation which will assist us in many ways,'' she said.
Dr McKinstry grew up at Barnadown and represented Mt Pleasant in netball.
She heads the Allied Health Faculty at La Trobe University Bendigo which comprises studies in physiotherapy, occupational therapy, speech pathology, podiatry and exercise physiology.
Dr McKinstry is passionate about rural health.
''I am very keen to encourage a growing local workforce drawing from regional graduates and providing a good fit workforce for the health service,'' she said.
''There are many outstanding young people out there and we can target their recruitment for the benefit of REDHS.''
Ms O'Sullivan, a solicitor who attended Rochester Secondary College, is the principal of Bendigo law firm O'Sullivan-Johannsen.
She was thrilled to join the board.
''I believe the health service is well placed to take advantage of developments at both Bendigo and Echuca while continuing to offer an outstanding service to the community,'' she said.
''I grew up in the district and I am pleased to be able to give something back to the community in this role.''
Thankyou for your comment.Your comment will appear once it has been approved by MMG staff.
Auld takes top Tassie role
Goulburn Valley football identity Rob Auld has been unveiled as AFL Tasmania's number one man.
A bold, gold prediction
After building his form in a consistent effort during the past 12 months, Mulwala double trap shooter James Willett has staked his claim on possible Olympic gold after taking out the ISSF World Cup last week.
Respected Aboriginal elder dies
The Aboriginal and wider community is mourning the death of revered Bangerang Aboriginal elder, Uncle John ''Sandy'' Atkinson.
Good deed done for the good book
BIBLE which has been used in Echuca for the past 144 years will be rededicated at a special service in the Hare St Uniting Church on Sunday morning.
Ticket selling is now in with the mail
ROCHESTER V/Line travellers can now buy tickets in their home town again.
Thieves nick charity tin
Lions Club charity money was stolen from a Kyabram barbershop Tuesday morning.
Lions lick wounds
Seymour suffers disappointing loss to Euroa
Tribunal abolished
Barooga transport owner-operator Glen Kearney says he is relieved the Federal Government has abolished the Road Safety Remuneration Tribunal.
Rail trail progress is on track for growth
DESPITE criticism from within the community over a perceived lack of use, the O'Keefe Rail Trail has enjoyed good traffic over the past couple of weeks, with more to come.
Pairs event scoops top award
he success of the 2015 Barooga Sports Classic Pairs event has made the organisers the worthy recipient of the Berrigan Shire's Event Management award at the Berrigan Shire Business and Environment Awards.
Elisabeth's fight
School fundraises for student with leukaemia.
Murray Goulburn cuts milk price
Australian Dairy Farmers Limited has expressed disappointment at the announcement made by Murray Goulburn Co-operative about their revised opening milk price.
Benalla All Blacks fall short
The Panthers netballers failed to post a win against Greta on Saturday.
The News magazines are online - read high quality magazines in your time. Check in regularly for the latest editions.
Riverine Herald's well regarded locally produced magazines. They're now online, so you can read them whenever and wherever you like.
Search for published and unpublished photos from McPherson Media Group newspapers and magazines. All our photos are available to purchase.
Place an advertisement in any one of McPherson Media Group's local newspapers.


text:
Follow along with step-by-step beading projects and share your designs with beaders around the world—it's quick & easy!
- "Dream Catcher Necklace and Earrings": on
"LOVE!! I will ditto Kye's comment because it says exactly what I would say! …" read »
- "Area 51 Necklace": on
"I, too, really like the shape of those stone beads, and must say that your name…" read »
- "Really, Really, Really Long Necklace!": on
"Moogie, I LOVE 'really long' necklaces! And, Yes, they can be worn so many different…" read »
- "Silver & Blue Kumihimo Necklace": on
"Moogie, Kumihimo looks like so much fun, but very hard to do. I didn't know…" read »
- "Wirewrapped Rings by JCL": on
"All I can say is AWESOME work! Absolutely beautiful …" read »
- "Confetti Waterfall and Friends": on
"Those orphan beads sure make a powerful punch in this design! Love the carefree, uplifted…" read »
- "Loomed Bracelet": on
"This is outstanding work! The pattern is beautiful and perfect for us Southwest gals. …" read »
- "Pendant obsessed": on
"Khristin, sorry for the late comment, and everyone has said it....but these are so cool! …" read »
- "A name? No idea": on
"The Czech rondelles look lovely by themselves along with your wirework. The swirls, the blue…" read »
- "Captive Amethyst": on
"Beautiful wirework! 'Amazing' says it all with a stone so small.…" read »
- "Freels the Love": on
"Love the colors you chose! …" read »
- "Elements Bracelet": on
"I really love this, and you must have a great stash! The mix of colors, shapes,…" read »
- "Ancient River Goddess": on
"I love the look of this, and it does make me think of an ancient goddess.…" read »
- "Our Precious Planet": on
"I so appreciate all of your comments. This one was fun to make, especially picking…" read »
- "Buffalo Bracelets": on
"OH MY! I think these bracelets are incredible...brilliant...fabulous! Love the leather wraps around the…" read »
- "One for Me": on
"Angela, this is absolutely a stunning piece!! Your work is always fantastic, and your eye…" read »
- "Fun In Tibet": on
"Lovely necklace! You've highlighted those Tibetan beads perfectly with the coral …" read »
- "Somewhere over the Rainbow": on
"I love the flow of color in this rainbow design--no wonder you got some orders for…" read »
- "In A Soft Blue Focus": on
"CAS, these handmade microscope slide pendants are fantastic! I saw an idea like this in a…" read »
- "strange new worlds": on
"Love the style of your necklaces, and the display is great--no wonder you did really good!…" read »
- "Progression of a Cuff": on
"Absolutely stunning with the clear crystal beads! Thank you so much for the photos on…" read »
- "custom design bracelets": on
"Beautiful work! …" read »
- "Summer in Brittany wrap bracelet": on
"I'd die to wear this with my jeans--Love the casual, colorful look! …" read »
- "Swashbuckling Sweetheart": on
"Lauren, this is a favorite for me--love the multi-strands of coral in this design. Very…" read »
- "Thimble of time": on
"Such a creative idea and use of thimbles! For the life of me, I can't…" read »
- "Tree of Life": on
"Very nice! I really like the Czech horse eye beads--the colors say earth and sky…" read »
- "Elephant Festival": on
"Ali, very cool design using the acrylic tusk! I love the way your wrapped the…" read »
- "Tranquility": on
"I love this! Really caught my eye!…" read »
- "Our Precious Planet": on
"Very creative! Love the idea of this!!! It's beautiful!…" read »
- "Our Precious Planet": on
"Welcome back CC! I love everything about this beautiful necklace! Gorgeous design, beads and colors, what…" read »
- "Ancient Earth": on
"Wow! This one looks like you snatched it off an African warriors neck! Fantastic design!…" read »
- "River Song": on
"Love everything about this! It's streamlined yet there is a lot to look at. The leather…" read »
- "Tweet": on
"Gail, I had a 4x6 sheet of copper and stamped different rubber stamped designs on it.…" read »
- "Painted Pony": on
"Gorgeous!…" read »
- "Summer Wind Keychain": on
"Absolutely wonderful idea! This is such an easy to make ultra cute key chain idea.…" read »
- "River Force": on
"Wow, kye! This is beautiful! I love the mix of metals and the soothing colors of…" read »
- "Elegant Labradorite": on
"Labradorite!! Love! And a great new use for those spacers!…" read »
- "River Force": on
"Admire your chain maille artistry! The links make this necklace very special.…" read »
- "River Song": on
"So much to love about this piece...the variety of subtle colored stones with the copper is…" read »
About this design:
In early July Pam (the Funky Tulip) posted an intriguing earring design ('Twist Me Around') featuring some of her lampwork beads hanging from copper wire corkscrews. About the same time, Katherine (KH) posted 'Summer Flower' earrings, with trios of glass flower bells. I loved both designs, and composed a hybrid of the 2 designs. (The tiny wire snarls inside the flower bells are another tip of the hat to KH's work.) Thank you for the inspiration!
Components:Copper wire and pressed glass
Read the comments (or add your own)
Love the title and love the earrings! Adorable!
Mary I absolutely love those earrings!!!! Great minds must think alike because this morning I reached for my Bells of Ireland earrings. I hope you enjoy yours as much as I have enjoyed mine
Katherine – They are so fun… and I've gotten compliments on them when I've worn them.
Mary, have you tried making your own copper earwires? The are so easy to make and by either squaring the top or making longer tails you don't have to worry about them falling out of your ears. When I was at Oshkosh last week we had a heck of a storm blow through, and if I had been wearing standard store-bought earwires I am sure that they would have blown right out of my earlobes. Katherine
I love these!
I've started to make most of my earwires. I love that I can vary the size of the curve to complement the earring design. And the extra long tails ensure they stay in my ears.
These are adorable! Love them!!
Absolute delightful ear rings.
Great design..and versatile! so cute..
Thank you for all the kind comments – but most of the credit is due to Pam & Katherine!
KH: yes, sometimes I make my own earwires – see 'Reposing Reptile' & 'AZ Hummingbird' for some examples – doing so is fun & creative, but most of the time I am lazy and use pre-made ones. I am lucky to be one of the people who doesn't lose earrings easily – must have robust earlobes???
Since I started wearing my handmade pure copper earwires I have had fewer problems with sore earlobes – even if I wear them several days straight and don't remove them at night. Some of the commercial earwires must contain mystry metal.
Great earrings, Eeka!
Such lovely earrings !
Isn't it great when you can combine several designs into your own unique style? These earrings are absolutely adorable! No wonder you get lots of comments about them!
Your title made me giggle, too!
KH – a friend has found that she is not sensitive to the metal in earwires after all – she is sensitive to commercial metal cleaners/coatings! She now cleans her metals with a pinch of dry baking soda on a soft cloth… no more problems!
CCS: What can I say – I see past, I think earrings!
er, that would be pasta, not past
Add your thoughts!
Sign up for a Lima account to comment—it's quick and free!
Already have an account? Just log in.


text: Today's One Day Build is a homecoming for Adam, in a few ways. Using only one type of material and one cutting tool, Adam makes an architectural scale model of the house he grew up in. It's a walk down memory lane, and a return to the basics of building! Find a bonus clip from this build here!


text:
Lawyers - All in Desoto
Below is a list of businesses listed within our directory. If you do not see your business within the list below, you can submit it for addition to this list. Adding your business will feature your listing above Standard listings.
Bailey Bill W Attorney - Desoto, TX - Phone: (972) 230-0101
Boyanton Janet - Desoto, TX - Phone: (972) 298-6111
Brown & Tate Law Firm - Desoto, TX - Phone: (972) 224-2552
Brown Lorenzo & Associates - Desoto, TX - Phone: (972) 224-7555
Clardy- Thelma Sanders Attorney - Desoto, TX - Phone: (972) 298-6001
Hepner Fred Attycpa - Desoto, TX - Phone: (972) 780-8363
Ingram Willie F Senior Attorney - Desoto, TX - Phone: (972) 780-6144
Kurth Scott Attorney at Law - Desoto, TX - Phone: (972) 224-5534
Law Offices of Fuller & Eason - Desoto, TX - Phone: (972) 228-8239
Law Offices of James P Moon PLLC - Desoto, TX - Phone: (469) 567-1530
Helpful Definition for: Lawyers - AllLawyers in Desoto are professionals with an extensive knowledge of law within Texas and who practice law as well. The job of a lawyer demands the practical application of abstract legal theories and knowledge for solving specific individualized problems, or to advance the interests of clients or third parties.
The responsibilities of a lawyer vary significantly across legal jurisdictions. The following are the major responsibilities that are common to most of the states oral argument in the courts: Research and Drafting of court papers, Advocacy (written and oral) in administrative hearings, Client Intake and Counseling (with regard to pending litigation), Legal advice, Protecting intellectual property, Negotiating and Drafting contracts, Conveying, Carrying out the intent of the deceased, and Prosecution and Defense of criminal suspects in Texas.
Some jurisdictions like Texas grant a diploma privilege to certain institutions, so that the primary qualification for practicing law is merely earning a degree or credential from those institutions. While in some countries a formal apprenticeship with an experienced practitioner is required. The career structure of lawyers in Desoto vary extensively. In most common law countries, besides private practice, lawyers can become a prosecutor, government counsel, corporate in-house counsel, administrative law judge, judge, arbitrator, law professor, or politician. Non-legal jobs, such as corporate executive, government administrator, investment banker, entrepreneur, or journalist are the alternate career options.
Recent News from the Green Blog
Governor Cuomo Announces 900 Solar Projects Underway Through 26 Community Solarize Campaigns Across The State
"Solarize" campaigns are encouraging homes and businesses throughout the state to install solar – State will support another 31 "Solarize" campaigns set to begin this spring (Long Island, NY) Governor Andrew M. Cuomo today announced that 900 solar projects are underway through 26 community "Solarize" campaigns across New York State. A component of the NY-Sun program and the Governor's comprehensive..


text:
Sorry, but you haven't selected any favorites yet. Click here to go back and find some favorites.
Or Try One of These Episodes
College Wild Parties
Skanks Alot Bro - V2
14 Votes
Her First Anal Sex
67 Votes
Boob Exam Scam
Krystal-Lynn Lovely - V2
4 Votes
College Wild Parties
Sunshine sex-fest - V2
34 Votes
Spit Swappers
Slippery When Wet
0 Votes
Her First Lesbian Sex
Paige Love & Mariah Milano
200 Votes
Teens For Cash
Brianna Beach and Dr Lovemore - V2
3 Votes
Extreme Holly
Cum Snorting
15 Votes
My Sex Tour
Black Diamond
6 Votes
Teen Anal Pounding
Haileey James
103 Votes
Squirt Hunter
Annie Cruz - V2
22 Votes
Blow Job Races
Nicole & Jackson
6 Votes
Her First DP
Loads On My Face - V2
20 Votes
Back Seat Bangers
Nicki - V2
35 Votes
Private Party
2 Votes
My Sex Tour
Sexy Veterinarian
16 Votes
Milf Seeker
Sara Jessie
225 Votes
Asian Parade
Tia Ling
132 Votes
Her First Anal Sex
Candace Raines - V2
43 Votes
Her First DP
Faye Gets a Ride
58 Votes
Orgy Sex Parties
Love Mound
65 Votes
Gang Bang Squad
Fantasy Skye
77 Votes
Orgy Sex Parties
Ballroom Bliss - V2
47 Votes
Housewife Bangers
107 Votes
Black Cocks White Sluts
20 Votes
Back Seat Bangers
78 Votes
Teens For Cash
Amber - V2
6 Votes
Wild Fuck Toys
Tyra - V2
17 Votes
Cutest Girls
2 Votes
Couples Seduce Teens
Melanie Scott
185 Votes
Bang Boat
154 Votes
Her First Lesbian Sex
Carol & Clara G
7 Votes
First Date First Fuck
13 Votes
Her First DP
Taryn Thomas
65 Votes
Extreme Alex
Lesbian Anal Gape
15 Votes
Wife Switch
Porn Panorama
24 Votes
Extreme Alex
Anal Threesome
42 Votes
Milf Seeker
Rubee Tuesday
79 Votes
Wild Fuck Toys
Sindy Lange - V2
10 Votes
11 Votes


text:
ILLiad Transaction Deletions 4/17/16
On Sunday, April 17, 2016, all ILLiad requests dated before 1/1/2013 that are at the status of "cancelled" or "request closed" will be deleted from ILLiad.
Please take a moment to look through your ILLiad Request history and save any requests that you would like to keep. To do this, log into your account and on the left-hand side menu, choose Request History. Click on the requests you would like to keep and either print out or copy the information to your own files.
Transaction deletions occur annually every spring semester. If you have any questions, please contact email@example.com.
Requests for items held at the Hirsh Health Sciences Library are now filled free of charge for members of the Tufts community!
And, students, this does not count against your 20 free interlibrary loan requests through ILLiad per year.
We recognize that there may be many reasons you can't come into the library to grab that article or book chapter you need. Therefore, we are pleased to announce that we will now scan articles and book chapters found in the Hirsh Health Sciences Library, turn them into pdfs, and send them to you…for FREE!
Just submit an ILLiad request for the item in question and we will deliver it to you through your ILLiad account. For more information, please review our ILLiad Fee Policy. Questions? Email email@example.com.
ILLiad Maintenance: Sunday 6-10AM
ILLiad will be unavailable on Sunday October 12th from 6:00am – 10:00am due to a system upgrade. Please plan your work accordingly. We are sorry for the inconvenience. If you have any questions or comments please call 617-636-6705 or email email@example.com.
New look for ILLiad interlibrary loan service!
You may have already noticed that your ILLiad (hyperlink: http://go.tufts.edu/ILLiadhhsl) account has a new look with easier to fill-in request forms and more accessible account features. Please let email@example.com know if you have any questions or comments about using the new site.
An Easier Way to Request Books
Recently, the Tufts University libraries banded together and instituted an entirely new way to order books from within our library system. You no longer have to log into ILLiad to order a book from Tisch, Ginn, Vet, or any of the other Tufts University libraries – for now on, it's is as easy as 1-2-3!
Step 1: Once you've searched the catalog and found the book is only at one of the other libraries, click the "Request Item" button at the top of the page.
Step 2: Log in, using either your UTLN or your Tufts barcode info.
Step 3: Make sure your location on the drop-down menu says "Hirsh Health Sciences Library," add a date if it's a dated request (for instance, if it's for a research paper, and won't be any use after the paper's due date passes), and click Submit. You're done!
You're all set! If the book is available, then your request will generally show up in around 2 – 3 business days. Feel free to visit the desk or call us at 617.636.6706 if you have any questions or run into any problems.
Happy requesting!
Wondering About Interlibrary Loan Fees? Read More!
Need to request a book, journal article, or other item not at Hirsh? Our Head of Interlibrary Loan, Judy Rabinowitz, answers your questions about fees and charges below.
Frequently Asked Questions about Interlibrary Loan Fees and Payment
- Will I be charged?
- Faculty and staff in the Tufts community are charged $4 per request (e.g., journal article, book, etc.) for items in the Hirsh Health Sciences Library collection or from a library outside of Tufts. Students are allotted 20 free requests per academic year.
- Will I get an invoice?
- That depends. If there is a charge for your ILLiad request, you will receive an email in the month following the completion of your request with the invoice attached. Alternatively, if debiting a Tufts deptID, you can setup automatic payments and receive no invoices directly.
- How do I pay these invoices?
- Payments can be made by credit card (no Tufts Pcards), or (U.S.) check made out to Tufts Hirsh Health Sciences Library and brought in-person/mailed to:
Document Delivery Department
Tufts University Hirsh Health Sciences Library
145 Harrison Avenue
Boston, MA 02111
- How do I pay using a Tufts DeptID?
- Log into ILLiad and add the Tufts DeptID and account number information in the 'Payment and Profile' section. Then, when completing an ILLiad request form, select the account, and payment will automatically be made for that request and you will not receive an invoice soliciting payment.
- How can I find out more about ILLiad?
- Check out Document Delivery Policies and Procedures.
Tufts Hirsh Health Science Library
telephone: 617-636-6706
e-mail: firstname.lastname@example.com
- Tips & Tricks (69)
- News & Events (115)
- Outside News & Events (30)
- Book/Resource Reviews (40)
- New Titles & Resources (41)
- Hours (42)
- Announcements (153)
Tags4th floor 5th floor affiliation Ask Leo book review circulation copyright crafts databases electronic resource electronic resources events extended hours food fun fun lab HHSL Hirsh Health Sciences Library holiday holidays hours ILLiad Interlibrary Loan library service desk library staff lunch new books open access open access week open workshop portals recipes resources restaurant review staff statistics stress relief summer survey Thanksgiving therapy dogs Tufts Hirsh Health Sciences Library Under10 website writing consultants
Follow Us on Twitter!
- RT @TuftsUniversity: The women's basketball team was recognized by the city of #Somerville for their outstanding season cc: @TuftsWbball ht… about 9 hours ago from Twitter Web Client ReplyRetweetFavorite
- RT @NatureNews: 7 chemical separations to change the world https://t.co/AxpNVS9xgP https://t.co/DuRB4EjjVm about 9 hours ago from Twitter Web Client ReplyRetweetFavorite
- RT @Reuters_Health: Making medicine cheaper: France presses G7 on global regulation of drug prices. https://t.co/MMNtvhuvhm https://t.co/Qk… about 11 hours ago from Twitter Web Client ReplyRetweetFavorite
- RT @usfoodpolicy: Via @NPR: Under Attack, Commodity Promotion Programs Try To Hide Their Emails https://t.co/n1j0apa1Aa about 11 hours ago from Twitter Web Client ReplyRetweetFavorite
- RT @Teeth_Matter: Prevention pays off. Applying a dental sealant to a child's tooth is 1/3 the cost of filling a cavity https://t.co/aBXrXy… about 11 hours ago from Twitter Web Client ReplyRetweetFavorite
- Via @NPR: Biotech's Theranos Offers A Cautionary Tale For Silicon Valley https://t.co/5zwukw0s4A about 12 hours ago from Twitter Web Client ReplyRetweetFavorite
Tufts HHSL on Facebook