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IslaMar Vacation Villa #2 Norte 1BR/1Bath Holiday Rental
This lovely second floor Cozumel vacation rental apartment has a bedroom with a king-sized bed and ensuite bath with separate living and bedroom areas. This villa is perfect for a couple or a single traveler and comes with a pull out sofabed in the living room that will accommodates one (1) additional adult or two (2) small children. The villa has a dining area and full kitchen with built in electric stove top, toaster oven, microwave, refrigerator and bottled water is provided. Decor is tropical, casual & comfortable. Air Conditioning, TV/DVD-Cable, book/DVD library and and hammocks help ensure you relax and enjoy this tropical island living experience! A rinse tank area is available for your dive gear with stowage space in the lockers near the pool/spa where you can sit and tell "tall tales" after a day of diving!
This vacation rental villa is very spacious and bright with a lovely front veranda that faces the sunrise where guests can sit and enjoy their morning coffee or relax in a hammock and listen to the morning songbirds. Or rinse your dive/snorkel gear out front near the pool/spa while you share "tall tales" of the day's diving or snorkeling with other Islamar guests! All of our guests and staff are super friendly!
Downstairs there is a garden, lawnchairs, a pool/spa, dive lockers, rinse tank, outdoor shower and hammocks to enjoy. If you are a frequent visitor to the island, moving out of the hotel zone and integrating into the culture is the "next step" to becoming "a local!" This wonderful IslaMar Vacation Villa Rental is the perfect way for visitors to transition from "hotel staying" to an "island living" experience in Cozumel
Book today and make Islamar Vacation Villa Rentals part of your next Cozumel vacation package!
Accommodation Specifics
IslaMar Vacation Villa #2 Norte 1BR/1Bath Holiday Rental
IslaMar Vacation Villas
COME & SEE ~ Renovations & 38 - 40" Plasma TV's added ~ ready for 2016!!!
Maximum of three (3) Adults
Villa has one (1) king-sized bed
There is also a sofa pullout in living area for one (1) Adult or two (2) Kids under 5 years
Full Kitchens & Bottled Water
Air Conditioning & Ceiling Fans
TV-Cable/DVD & Phone For Local Calls + FREE Wi-Fi
Privacy & Security (10' privacy wall surrounds the property)
Pool/Jacuzzi with Tranquil Waterfall
Open Courtyard with Garden
Sunbathing & Hammock Areas
Dive Equipment Rinse/Dry Area
Storage Bins for Dive/Snorkel Gear
Charcoal BBQ Grills
Host & Staff On Site Daily for Guest Needs
Services Available Upon Request:
Activity Coordination
In-House Masseuse
In-House Chef services
In-House Basic Spanish Lessons
In-House Laundry
US$ - 74 / night
US$ - 518 / week
PLUS 19% Local Fees
NOTE: Rates are Double Occupancy.
Surcharge of $ 15/Night applies for additional occupant.
Please inquire about special Holiday and Monthly rates
Personal Experiences
Submit Feedback
Stay (01/09/2013) - Our eight (8) nights here in #2 Villa were really enjoyable and relaxing. The weather could not have been nicer for being outside or walking to town or in the neighborhood. The hole fish at Carlos was delicious, food at Los Palmos divine and local mom and pop restaurants worth the visit. Zuri is very special and does a great job of cleaning and so pleasant each day.
Kathy & Tom S. ~ Grand Rapids, OH
Stay (03/19/2013) - This has been a wonderful vacation thanks to Sherri, Miguel and Zuri. IslaMar Villas is truly relaxing, the swimming pool was great and we enjoyed the walks to the downtown area and ocean! We will be back!
Liz D. & Clarence B. ~ Sylvan Lake, Alberta, Canada
Stay (03/22/2011) - Enjoyed our visit to Cozumel and staying at IslaMar. It is nice to be off the beaten path, but a culture shock for Midwestern USA. You staff was GREAT. Thanks.
Keith & Jane M. ~ Ohio & Florida
(02/07/2015) - We rented a one bedroom for 2 weeks. It was our first time in Mexico and Sherri and her staff were great to work with. The property is ideally located in the middle of town. We often walked to eat and shop and had rented a car which took us to many great dive sites. We really enjoyed when all the others staying there would often get together for a drink and to talk about our days adventures. All the people there gave great advice and we met many great people that we had a lot in common with. Most were long term residents. We would recommend this to couples going to Cozumel.
Barry G. ~ Camrose, AB, Canada
As former home owners in Cozumel, IslaMar Villas will be our new home in Cozumel. This is a wonderful substitute for our home. We lost a fountain and gained a swimming pool. We always look forward to coming to Cozumel! You 3 ladies just make it more special for us. Always here to help us out when we need it!!! Zuri is a very special persona and does such a great job. The office staff is always outstanding and very professional. Sherri, you always make us feel like family. Hate to go home!!
Pam & Art B. ~ Portland, OR
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At the end of March, Tesla finally revealed their affordable new electric vehicle called the Model 3. Within a week of the Model 3 reveal, Tesla received over 300,000 reservations for the $35,000 EV. However, some people may be reserved about the Model 3 because it is a sedan. For
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Home > Press > Military to study better pain relief in battle zones
University of Michigan scientists win $1.3M grant to create and test nanoparticles that may deliver morphine to wounded soldiers faster and more safely
University of Michigan scientists have received a pilot grant of nearly $1.3 million from the Defense Advanced Research Projects Agency to test whether nanoparticles can solve a pressing problem in battle zones like Iraq: how to administer sustained, safe doses of the most effective painkillers to injured soldiers, long before they can reach expert medical help.
The ultimate goal is to develop tiny drug-bearing particles that a fellow soldier "or perhaps the injured soldier himself" could inject with a pen-like device, even in the heat of combat. That would solve one of the challenges now. Morphine, an effective painkiller that the military commonly uses for the acute pain of battle injuries, currently needs to be injected by skilled medical personnel and has to be monitored carefully to control its troublesome tendency to suppress normal breathing.
"This proposal provides an approach to achieve sustained, safe pain control on the battlefield," says the U-M research team's leader, James R. Baker, Jr., M.D., director of the Michigan Nanotechnology Institute for Medicine and Biological Sciences.
"It uses different medicines coupled to polymers to release drugs and antidotes to provide adequate pain relief while avoiding complications. If successful, it could markedly improve the treatment of soldiers in the field," says Baker, the Ruth Dow Doan Professor of Internal Medicine in the U-M Medical School.
The work could have a broad impact. In the war in Iraq, more than 26,900 U.S. soldiers have been wounded in action as of late July. It's known that battlefield pain, if not relieved adequately, can lead to post-traumatic stress disorders.
A large multidisciplinary team of U-M scientists will use the grant to design multipurpose nanoparticles and test how well they perform several tasks under simulated physiological conditions in the laboratory. Ultimately, they want the particles to be able to:
* control the release of morphine over extended periods before a soldier can be evacuated to a military acute care facility,
* continuously monitor the soldier�s breathing and if needed, release a drug called Naloxone that is used to counter morphine�s effects on breathing.
The team, which includes synthetic, analytical and medicinal chemists, will expand on the use of dendrimer platforms, a technology previously developed at the U-M. They will design ultra-small polymer particles called dendrimers capable of carrying morphine and Naloxone into the body and releasing them in controlled amounts. They will develop sensors that the dendrimers will also carry to monitor a soldier's respiration and trigger Naloxone release, or halt it, as needed.
If the concept proves successful after the first year of in vitro studies, Baker and his team want to apply for continued DARPA funding to proceed with animal and eventually human studies.
Other U-M team members include Abraham F. L. Vanderspek, M.D., associate professor of anesthesiology; Brent Ward, MD, DDS, FACS, assistant professor of oral and maxillofacial surgery and program director of Oncologic Maxillofacial/Head & Neck Surgery; Xue-min Cheng, Ph.D., research associate professor, Department of Internal Medicine and M-NiMBS; a medicinal chemist, Rameshwer Shukla, Ph.D., who is a research investigator in the Department of Internal Medicine and M-NiMBS; a medicinal chemist, Xiangyang Shi, Ph.D., who is a research investigator in the Department of Internal Medicine and M-NiMBS; a polymer chemist, Baohua Huang, Ph.D., who is a research investigator in the Department of Internal Medicine and M-NiMBS; a polymer chemist, Xiangdong Bi, Ph.D., Department of Internal Medicine and M-NiMBS; an organic chemist, Mark M. Banaszak Holl, Ph.D., professor of chemistry, applied physics and biophysics in the U-M College of Literature, Science, and the Arts, and of macromolecular science and engineering in the U-M College of Engineering; Ankur Desai, M.S., Department of Internal Medicine and M-NiMBS; an analytical chemist, Thommey P. Thomas, Ph.D., research assistant professor, Department of Internal Medicine and M-NiMBS; Bradford G. Orr, Ph.D., professor of physics in LS&A, director of the Academic Program in Applied Physics, and associate director of M-NiMBS; Alina Kotlyar, M.S., Department of Internal Medicine and M-NiMBS; and Thomas Dunham, B.S., of U-M Maxillofacial Surgery.
For more information on the U-M Nanotechnology Institute for Medicine and Biological Sciences, visit http://www.nano.med.umich.edu/
Funding for the study comes from the Defense Advanced Research Projects Agency, part of the U.S. Department of Defense.
Patent applications have been filed on related U-M dendrimer inventions, which have been exclusively licensed to Avidimer Therapeutics, an Ann Arbor based biotech company in which Dr. Baker has a financial interest.
About University of Michigan Health System
We are among the country's top institutions in federally funded research. We are prominent in the pursuit of discovery, in the translation of pioneering breakthroughs to the clinical and business settings, and in the dissemination of new knowledge to health care providers and the public at large.
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Danze Melrose D454512 Single Handle Pull Out Kitchen FaucetItem # HN-YOW2180
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Date: 1877 ca.
Description: "The Grand Regatta, at Devil's Lake, June 21st & 22nd, 1877." A crowd sits on the ground about to commence lunch at Devil's Lake.
Date: 1874 ca.
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Date: 1938
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Date: 1935 ca.
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Date: 1896-09-16 ca.
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Date: 1918 ca.
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Date: 1925-03-02
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International Immunology (INT IMMUNOL)
Journal description
International Immunology publishes a broad range of experimental and theoretical studies in molecular and cellular immunology conducted in laboratories throughout the world.
Current impact factor: 2.54
Impact Factor Rankings
|2016 Impact Factor
|Available summer 2017
|2014 / 2015 Impact Factor
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Impact factor over time
Impact factor
Additional details
|5-year impact
|Cited half-life
|Immediacy index
|Article influence
|International Immunology website
|Other titles
|International immunology online., International immunology
|Material type
|Periodical, Internet resource
|Document type
|Journal / Magazine / Newspaper, Internet Resource
Publisher details
- Pre-print
- Author can archive a pre-print version
- Post-print
- Author cannot archive a post-print version
- Restrictions
- 12 months embargo
- Conditions
- Pre-print can only be posted prior to acceptance
- Pre-print must be accompanied by set statement (see link)
- Pre-print must not be replaced with post-print, instead a link to published version with amended set statement should be made
- Pre-print on author's personal website, employer website, free public server or pre-prints in subject area
- Post-print in Institutional repositories or Central repositories
- Publisher's version/PDF cannot be used
- Published source must be acknowledged
- Must link to publisher version
- Set phrase to accompany archived copy (see policy)
- Eligible authors may deposit in OpenDepot
- The publisher will deposit in PubMed Central on behalf of NIH authors
- Publisher last contacted on 19/02/2015
- This policy is an exception to the default policies of 'Oxford University Press (OUP)'
- Classificationyellow
Publications in this journal
Article: T-cell adoptive immunotherapy using tumor-infiltrating T cells and genetically engineered TCR-T cells[Show abstract] [Hide abstract] ABSTRACT: Immunotherapy has received the expectation that it should contribute to the therapy of cancer patients for more than a hundred years. At long last, recent clinical trials of immunotherapy with immune checkpoint inhibitors as well as adoptive cell therapy with genetically engineered T cells have reported their remarkable efficacies. Nowadays, it is expected that T-cell adoptive immunotherapy can not only control tumor progression but even cure cancer in some patients. On the other hand, severe adverse events associated with efficacy have frequently been reported in clinical trials, suggesting that the assessment and control of safety will be indispensable in the future development of the therapy. New approaches in T-cell adoptive immunotherapy such as reduction of adverse events, targeting of new antigens, or utilization of allogeneic cells will open a new gate for less harmful and more effective immunological treatment of cancer patients.
Article: GYF-17, a chloride substituted 2-(2-phenethyl)-chromone, suppresses LPS-induced inflammatory mediator production in RAW264.7 cells by inhibiting STAT1/3 and ERK1/2 signaling pathways[Show abstract] [Hide abstract] ABSTRACT: GYF-17, a 2-(2-phenethyl)-chromone derivative, was isolated from agarwood and showed superior activity of inhibiting NO production of RAW264.7 cells induced by LPS in our preliminary pharmacodynamic screening. In order to develop novel therapeutic drug for acute and chronic inflammatory disorders, the anti-inflammatory activity and underlying mechanism of GYF-17 were investigated in LPS-induced RAW264.7 cells. The results showed that GYF-17 could reduce LPS-induced expression of iNOS and then result in the decrement of NO production. More meaningful, the expression and secretion of key pro-inflammatory factors, including TNF-α, IL-6 and IL-1β, were intensively inhibited by GYF-17. Furthermore, GYF-17 also down regulated the expression of COX2 and the production of PGE2 which plays important role in causing algesthesia during inflammatory response. In mechanism study, GYF-17 selectively suppressed phosphorylation of STAT1/3 and ERK1/2 during the activation of NF-κB, MAPK and STAT signaling pathways induced by LPS. Collectively, GYF-17 can intensively suppress the production of LPS-induced inflammatory mediators in RAW264.7 cells by inhibiting STAT1/3 and ERK1/2 signaling pathways and thereby shows great potential to be developed into therapeutic drug for inflammatory diseases.
- [Show abstract] [Hide abstract] ABSTRACT: Recent studies have shown that tumor cells acquire escape mechanisms to evade host immunity in the tumor microenvironment. Two key immune checkpoint pathways mediated by immunosuppressive co-signaling, the first via programmed cell death 1 (PD-1) and PD-1 ligand 1 (PD-1/PD-L1) and the second via cytotoxic T cell lymphocyte antigen 4 (CTLA-4) and B7 (CTLA-4/B7), have been previously described. Several clinical trials have revealed an outstanding anti-tumor efficacy of immune checkpoint inhibitors (anti-CTLA-4 antibody, anti-PD-1 antibody and/or anti-PD-L1 antibody) in patients with various types of solid malignancies, including non-small cell lung cancer, melanoma, renal cell cancer and ovarian cancer. In this review, we examine pre-clinical studies that described the local immune status and immune checkpoint signals in ovarian cancer, highlight recent clinical trials that evaluated immune checkpoint inhibitors against ovarian cancer, and discuss the clinical issues regarding immune checkpoint inhibitors.
- [Show abstract] [Hide abstract] ABSTRACT: Chimeric antigen-receptors (CARs) are engineered molecules designed to endow a polyclonal T cell population with the ability to recognize tumor-associated surface antigens. In their simplest form, CARs comprise a targeting moiety in the form of a single-chain variable fragment (scFv) from an antibody connected to various intracellular signaling domains allowing for T cell activation. This powerful approach combines the specificity of an antibody with the cytotoxic ability of a T cell. There has been much excitement since early phase trials of CAR-T cells targeting CD19 expressed on B cell malignancies demonstrated remarkable efficacy in inducing long-term, stable remissions in otherwise relapsed/refractory disease. Despite these successes, we have just begun to understand the intricacies of CAR biology with efforts underway to utilize this platform in the treatment of other, previously refractory malignancies. Challenges currently include identification of viable cancer targets, management strategies for potentially severe and irreversible toxicities, and overcoming the immunosuppressive nature of the tumor microenvironment. This review will focus on basic CAR structure and function, previous success and new approaches aimed at the broader application of CAR-T cell therapy.
- [Show abstract] [Hide abstract] ABSTRACT: Accumulated evidence obtained from various clinical trials and animal studies suggested that cancer vaccines need better adjuvants than those that are currently licensed, which include the most commonly used alum and incomplete Freund's adjuvant, because of either a lack of potent anti-tumor immunity or the induction of undesired immunity. Several clinical trials using immunostimulatory adjuvants, particularly agonistic as well as non-agonistic ligands for TLRs, C-type lectin receptors, retinoic acid-inducible gene I-like receptors and stimulator of interferon genes, have revealed their therapeutic potential not only as vaccine adjuvants but also as anti-tumor agents. Recently, combinations of such immunostimulatory or immunomodulatory adjuvants have shown superior efficacy over their singular use, suggesting that seeking optimal combinations of the currently available or well-characterized adjuvants may provide a better chance for the development of novel adjuvants for cancer immunotherapy.
Article: Mechanisms of tumor escape in the context of the T cell-inflamed and the non-T cell-inflamed tumor microenvironment[Show abstract] [Hide abstract] ABSTRACT: Checkpoint blockade therapy has been proven to be highly active across many cancer types but emerging evidence indicates that the therapeutic benefit is limited to a subset of patients in each cancer entity. The presence of CD8+ T cells within the tumor microenvironment or the invasive margin of the tumor, as well as the up-regulation of PD-L1, have emerged to be the most predictive biomarkers for clinical benefit in response to checkpoint inhibition. Although the up-regulation of immune inhibitory mechanisms is one mechanism of immune escape, commonly used by T-cell-inflamed tumors, exclusion of an anti-tumor specific T-cell infiltrate displays another even more potent mechanism of immune escape. This review will contrast the mechanisms of immunogenic, T-cell-inflamed, and the novel concept of non-immunogenic, non-T-cell-inflamed, adaptive immune escape.
- [Show abstract] [Hide abstract] ABSTRACT: Inflammatory responses contribute to host defense against harmful organisms and allergens, whereas a failure of immune tolerance can cause chronic inflammation including asthma. The lung has several innate myeloid cell subsets. Among these subsets, there are two types of macrophages: alveolar macrophages (AMs) and interstitial macrophages (IMs). However, compared with AMs, the role of IMs in lung homeostasis remains poorly understood. In this study, we characterized AMs and IMs in healthy and inflammatory conditions. Pulmonary IMs constitutively produce the anti-inflammatory cytokine IL-10 through activation of the TLR4/MyD88 pathway in a microbiota-independent manner. In addition to IMs, Foxp3+ Treg cells show persistent IL-10 expression in the lung, with IL-10-producing IMs more prevalent than Foxp3+ Treg cells. IMs, but not Foxp3+ Treg cells, increased IL-10 production in house dust mite- challenged mice, a model of human asthma. House dust mite-challenged Il10-/- mice exhibited severe lung pathology characterized by neutrophilia compared with that of wild-type mice. In addition, transplantation of wild-type IMs reduced neutrophilic inflammation, goblet cell mucus production, and decreased expression of lung IL-13 and Th17-related neutrophil-activating cytokines such as IL-17, GM-CSF, and TNF-α. Together, these results demonstrate that IL-10-producing IMs negatively regulate Th2- and Th17-mediated inflammatory responses, helping prevent neutrophilic asthma.
Article: Mammary Tumor Educated B cells Acquire LAP/TGF- and PD-L1 expression and Suppress Anti-Tumor Immune Response[Show abstract] [Hide abstract] ABSTRACT: B lymphocytes play a role in inhibiting the immune response against certain tumors, but the underlying mechanisms are poorly understood. EMT-6 mammary tumors grow well in wild type (WT) mice but show reduced growth in B-cell deficient µ-/- BALB/c mice (BCDM). WT mice demonstrate extensive B cell infiltration into the tumor bed, reduced CD8+ T cell and CD49+ NK cell infiltration, and markedly reduced cytolytic T cell response relative to BCDM. Expression of LAP/TGF-β1, CD80, CD86 and PDL-1 is significantly increased in tumor infiltrating B cells (TIL-B) relative to splenic B cells. LAP/TGF-β1 expression on TIL-B progressively increased from 5.4±1.7% on d8 to 43.1±6.1% by d21 post tumor implantation. Co-culture of EMT-6 tumor cells with naïve B cells ex vivo generated B cells (EMT6-B) with a similar immunophenotype to TIL-B. Purified TIL-B, or in vitro generated EMT6-B suppressed CD4+, CD8+ and CD4+CD25- T cell proliferation, and Th1 cytokine secretion, and also suppressed purified NK cell proliferation in response to IL-15, compared to naïve splenic B cells. Acquired B regulatory function required direct tumor cell: B cell contact, and was partially reversed by antibody to TGF-β or PDL-1, leading to tumor rejection in vivo. B cell acquisition of a suppressive phenotype following tumor infiltration may result in profound inhibition of T cell anti-tumor response.
- [Show abstract] [Hide abstract] ABSTRACT: CD4+ T cells are crucial for directing appropriate immune responses during host defense and for the pathogenesis of inflammatory diseases. In addition to the classical biphasic model of differentiation of T-helper 1 (Th1) and Th2 cells, unexpected increases in the numbers of CD4+ T cell subsets, including Th17, Th9, T follicular-helper (Tfh) and T-regulatory (Treg) cells, have been recognized. In the present review, we focus on how these various T-helper cell subsets contribute to the pathogenesis of immune-mediated inflammatory diseases. In particular, we focus on multiple sclerosis, psoriasis and asthma as typical model diseases in which multiple T-helper cell subsets have recently been suggested to play a role. We will also discuss various unique subpopulations of T-helper cells that have been identified. First, we will introduce the heterogeneous T-helper cell subsets, which are classified by their simultaneous expression of multiple key transcription factors. We will also introduce different kinds of memory-type Th2 cells, which are involved in the pathogenesis of chronic type-2 immune related diseases. Finally, we will discuss the molecular mechanisms underlying the generation of the plasticity and heterogeneity of T-helper cell subsets. The latest progress in the study of T-helper cell subsets has forced us to reconsider the etiology of immune-mediated inflammatory diseases beyond the model based on the Th1/Th2 balance. To this end, we propose another model — the pathogenic T-helper population disease-induction model — as a possible mechanism for the induction and/or persistence of immune-mediated inflammatory diseases.
Article: Immunomodulatory drugs inhibit TLR4 induced type-1 interferon production independently of Cereblon via suppression of the TRIF/IRF3 pathway[Show abstract] [Hide abstract] ABSTRACT: Thalidomide and its derivatives, collectively referred to as Immunomodulatory drugs (IMiDs), are effective inhibitors of inflammation and are known to inhibit TLR induced TNFα production. The identification of Cereblon as the receptor for these compounds has led to a rapid advancement in our understanding of IMiD properties, however, there remain no studies addressing the role of Cereblon in mediating the suppressive effect of IMiDs on TLR responses. Here, we developed Cereblon deficient mice using the CRISPR-Cas9 system. TLR induced cytokine responses were unaffected by Cereblon deficiency in vivo. Moreover, IMiD treatment inhibited cytokine production even in the absence of Cereblon. The IMiD induced suppression of cytokine production therefore occurs independently of Cereblon in mice. Further investigation revealed that IMiDs are potent inhibitors of TLR induced type-1 interferon production via suppression of the TRIF/IRF3 pathway. These data suggest that IMiDs may prove effective in the treatment of disorders characterised by the ectopic production of type-1 interferon. Significantly, these properties are mediated separately from Thalidomide's teratogenic receptor, Cereblon. Thus, certain therapeutic properties of Thalidomide can be separated from its harmful side effects.
- [Show abstract] [Hide abstract] ABSTRACT: Genome-wide association studies (GWAS) for autoimmune diseases (ADs) have identified many risk loci and have provided insights into the etiology of each disease. Some of these loci, such as PTPN22, IL23R, and STAT4, are shared among different ADs, and the combination of risk loci may determine an individual's susceptibility for a disease. The majority of GWAS loci are expression quantitative trait loci (eQTLs), where disease-causing variants regulate expression of neighboring (or sometimes distant) genes. Because the eQTL effects often are cell type-specific, the incorporation of epigenetic data from disease-related cell types and tissues is expected to refine the identification of causal variants. The cumulative eQTL effects in multiple genes may influence the activity or fate of immune cells, which in turn may affect the function of the immune system in individuals. In this paper, I review the etiology of ADs by focusing on important immune cells (Th1, Th17, and regulatory T-cells), important pathways (antigen receptor signaling and type I interferon signaling), and relevant genes identified in GWAS.
Article: Antimicrobial cathelicidin peptide LL-37 inhibits the pyroptosis of macrophages and improves the survival of polybacterial septic mice[Show abstract] [Hide abstract] ABSTRACT: LL-37 is the only known member of the cathelicidin family of antimicrobial peptides in humans. In addition to its broad spectrum of antimicrobial activities, LL-37 can modulate various inflammatory reactions. We previously revealed that LL-37 suppresses the lipopolysaccharide (LPS)/ATP-induced pyroptosis of macrophages in vitro by both neutralizing the action of LPS and inhibiting the response of P2X7 (a nucleotide receptor) to ATP. Thus, in this study, we further evaluated the effect of LL-37 on pyroptosis in vivo using a cecal ligation and puncture (CLP) septic model. As a result, the intravenous administration of LL-37 improved the survival of the CLP septic mice. Interestingly, LL-37 inhibited the CLP-induced caspase-1 activation and pyroptosis of peritoneal macrophages. Moreover, LL-37 modulated the levels of inflammatory cytokines (IL-1β, IL-6 and TNF-α) both in the peritoneal fluids and sera, and suppressed the activation of peritoneal macrophages (as evidenced by the increase in the intracellular levels of IL-1β, IL-6 and TNF-α). Finally, LL-37 reduced the bacterial burdens both in peritoneal fluids and blood samples. Together these observations suggest that LL-37 improves the survival of CLP septic mice by possibly suppressing the pyroptosis of macrophages, and inflammatory cytokine production by activated macrophages as well as bacterial growth. Thus, the present findings imply that LL-37 can be a promising candidate for sepsis due to its multifunction based on the inhibition of pyroptosis, modulation of inflammatory cytokine production and antimicrobial activity.
Article: CXCR6 regulates the recruitment of pro-inflammatory IL-17A-producing T cells into atherosclerotic aortas[Show abstract] [Hide abstract] ABSTRACT: The adaptive immune response is involved in the development and progression of atherosclerosis and IL-17A(+) cells play a role in this disease. While elevated number of CD4(+) IL-17A(+) (Th17) and IL-17A(+)TCRγδ(+) T cells are found within murine atherosclerotic aortas and human plaques, the mechanisms governing IL-17A(+) T cell migration to atherosclerotic lesions are unclear. The chemokine receptor CXCR6 is expressed on several T cell subsets and plays a pro-atherogenic role in atherosclerosis. Here, we used CXCR6-deficient (Cxcr6(GFP/GFP)) Apolipoprotein E-deficient (Apoe(-/-)) mice to investigate the involvement of CXCR6 in the recruitment IL-17A(+) T cells to atherosclerotic aortas. Flow cytometric analyses revealed reductions in Th17 and IL-17A(+)TCRγδ(+) T cells within aged Cxcr6(GFP/GFP)Apoe(-/-) aortas, in comparison with age matched Cxcr6(GFP/+)Apoe(-/-) aortas. While CXCR6-sufficient IL-17A(+) T cells efficiently migrated towards CXCL16, the migration of CXCR6-deficient IL-17A(+) T cells was abolished in transwell assays. Importantly, the recruitment of Cxcr6(GFP/GFP)Apoe(-/-) IL-17A(+) T cells into the aortas of Apoe(-/-) recipients was markedly reduced in short-term adoptive transfer experiments. Altogether these results demonstrate an important role of CXCR6 in the regulation of pathological Th17 and IL-17A(+)TCRγδ(+) T cell recruitment into atherosclerotic lesions.
Article: Leptin deficiency down-regulates IL-23 production in glomerular podocyte resulting in attenuated immune response in nephrotoxic serum nephritis[Show abstract] [Hide abstract] ABSTRACT: Leptin, one of the typical adipokines, is reported to promote Th17 cell responses and to enhance production of proinflammatory cytokines. To clarify the role of leptin in the regulation of the IL-23/IL-17 axis and the development of kidney disease, we used a murine model of nephrotoxic serum (NTS) nephritis (NTN). Sheep NTS was administered in wild-type C57BL/6J mice and food-restricted, leptin-deficient C57BL/6J-ob/ob (FR-ob/ob) mice after preimmunization with sheep IgG. The profile of mRNA expression relevant to T helper lymphocytes in the kidneys was analyzed by quantitative real-time PCR (qRT–PCR). Cultured murine glomerular podocytes and peritoneal exudate macrophages (PEMs) were used to investigate the direct effect of leptin on IL-23 or MCP-1 production by qRT–PCR. Kidney injury and macrophage infiltration were significantly attenuated in FR-ob/ob mice 7 days after NTS injection. The Th17-dependent secondary immune response against deposited NTS in the glomeruli was totally impaired in FR-ob/ob mice because of deteriorated IL-17 and proinflammatory cytokine production including IL-23 and MCP-1 in the kidney. IL-23 was produced in glomerular podocytes in NTN mice and cultured murine glomerular podocytes produced IL-23 under leptin stimulation. MCP-1 production in PEMs was also promoted by leptin. Induction of MCP-1 expression was observed in PEMs regardless of Ob-Rb, and the leptin signal was transduced without STAT3 phosphorylation in PEMs. Leptin deficiency impairs the secondary immune response against NTS and down-regulates IL-23 production and Th17 responses in the NTN kidney, which is accompanied by decreased MCP-1 production and macrophage infiltration in the NTN kidney.
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.


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Annie Bryant
My Life in 8 Words
Author Revealed
Q. What is your motto or maxim?
A. "Everyone must do something to make the world more beautiful." - Miss Rumphius
Q. With whom in history do you most identify?
A. Louisa May Alcott
Q. What is your greatest achievement?
A. Bringing the Beacon Street Girls to life!
Q. Which living person do you most admire?
A. My mother
Q. What is your favorite occupation, when you're not writing?
A. Walking my dog.
Activity Sheets
To download a file to your computer right-click on the link and choose 'save file as'.


text:
i require to send app request to friends in my facebook profile. So can any one suggest me graph api available to achieve this, i prefer graph because i have been using the graph api for all other tasks. Thanks in advance.
Try this one you will get all your friends list which is there in your facebook.


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DEFINITION of 'Origination Points'
A type of fee borrowers pay to lenders or loan officers in order to compensate them for the role they play in evaluating, processing and approving mortgage loans. Credit history is one factor that plays a role in the amount of origination points a borrower needs to pay. Unlike the other types of points (for example, discount points), origination points are not tax deductible.
BREAKING DOWN 'Origination Points'
Typically, each single origination point represents 1% of the mortgage loan. For example, if you are borrowing $150,000 and the bank is charging you 1.5 origination points, you will end up paying $2,250 (or 1.5% of $150,000).
Since the amount of origination points required to be paid is not set in stone, borrowers may be able to negotiate the amount of origination points that they pay.
Closing CostsThe expenses, over and above the price of the property that buyers ...
Negative PointsA cash rebate paid by lenders to a mortgage broker or the borrower ...
Dual ApperA potential mortgage borrower who submits two mortgage applications ...
Good Faith EstimateAn estimate of the fees due at closing for a mortgage loan that ...
Mortgage Par RateAn interest rate used as the reference point for which a mortgage ...
No-Cost MortgageA mortgage refinancing situation in which the lender pays the ...
Credit & Loans
4 Steps To Attaining A MortgageIt starts with knowing your choices as well as your price range. We show you how to get there.
A Tax Primer For HomeownersGo beyond interest and find out how mortgage points affect your taxable income.
Credit & Loans
Mortgage Points: What's The Point?Learn how to pay less for your home in the long run, or save in the short run.
Options & Futures
Home-Equity Loans: The CostsLearn the factors to consider when comparing the different programs offered by various lenders.
Options & Futures
Score A Cheap MortgageHidden costs can create what looks like a good deal. Find out how to find the best mortgage possible.
Home & Auto
5 Reasons Not to Use Your Home Equity Line of CreditFind out why taking a loan from a home equity line of credit may be a bad idea, and why you should consider alternatives.
Mutual Funds & ETFs
Trends in Capital Flows: U.S. EquitiesAnalyze asset flow data for U.S. equity mutual funds and ETFs from 2014 and 2015 to identify changes in demand, investor sentiment and outlook.
Credit & Loans
Mortgage Refinance: Brick-and-Mortar vs. Online LenderUnderstand why refinancing your mortgage might benefit you, and compare using an online lender to working with a brick-and-mortar bank.
Mutual Funds & ETFs
iShares U.S. Construction vs. SPDR Homebuilders: Comparing Homebuilder ETFs (ITB, XHB)Learn why the U.S. housing sector may soon take off in 2016, and discover how to easily gain exposure to the sector, through these two exchange traded funds.
Home & Auto
The 3 Best Mortgage Lenders for RefinancingUnderstand the refinancing process and why it is often beneficial, and identify several lenders that offers the best refinancing deals.
What is the 1003 mortgage application form?Learn about the 1003 mortgage application form, what information it requires and why this form is the industry standard for ... Read Answer >>
What's the difference between short sales and foreclosures?Understand the difference between a short sale and a foreclosure; both result in the loss of a home, either through a sale ... Read Answer >>
How do you use the FNMA selling guide?Learn about Fannie Mae Selling Guide and find out details about how its parts provide support to the business relationship ... Read Answer >>
What is the average credit score for new homebuyers? (ELLI)Learn the average FICO score of approved and denied home loan applications, and find out how your credit score measures up ... Read Answer >>
Is an adjustable rate mortgage (ARM) safe?Learn why an adjustable rate mortgage (ARM) can be a safe option as long as the borrower is familiar with the underlying ... Read Answer >>
Do FHA loans require escrow accounts?Understand how FHA mortgages require escrow accounts for property taxes, homeowners insurance and mortgage insurance premiums ... Read Answer >>


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38, Irvington, NJ(If you are onterested in talking, please offer a means of communication). I am a practicing Christian but have learned there exist a depth to my Catholic faith beyond daily...
28, Elizabeth, NJI like to treat people the way. I would like to be treated. I am an overall easy going, simple person. Anything else you want to know, feel free to ask.
52, Hamilton Township, NJI look forward to meeting people who are willing to exchange ideas with me. Working in a health facility has given me the opportunity to interact with people from all walks of...
36, Little Ferry, NJI am an easy going and cool guy. Loves the serving god . Passionate about my life in christ. I love indoor games . Love hanging out with friends and family members ones in a w...
48, Union, NJI am here hoping to meet and make new friends, of the opposite gender. I have a wide range of things I like doing. Example I love listening to music. I love watching thought p...
40, Franklin Park, NJAm 5'9 all outgoing spontaneous guy. Am very athletic, down to earth and outgoing kind guy. I love working out as a hobby and love to read. I work in a brokerage industry in d...
38, Newark, NJi am young african guy from west africa.i live in new jersey .like go out with friend,restaurant ,movies,like sport.i am looking for a nice girl with whom i can do my life.a g...
36, Lakewood, NJI am compassionate person, with keen for new ideas. A resourceful, versatile and hardworking person. I enjoys meeting people from different background, with great respect for ...
32, Newark, NJi am passionate about logic and deductive reasoning. I look forward to peaceful and serene environment where there is no hate or envy but love. My parents are the most influe...
40, Merchantville, NJI am passionate about my faith, keeping physically fit and my service to the nation through my military service. The experiences that has influenced my life have been thos...
31, Union, NJAbout me in progress or currently unavailable...
54, North Brunswick, NJHello, I'm Irvelt. I'm very positive, Clean, Honest, Respectful,Friendly and easy going. I am looking for someone who's really want to rebuild a new family life. I' m a Caribb...
Catholic Dating By Major City:
- Jersey City,
- Trenton,
- Clifton,
- Newark,
- Toms River,
- Cherry Hill,
- Morristown,
- Edison,
- Elizabeth,
- Mount Laurel,
- Union,
- Brick,
- Hoboken,
- Freehold,
- Paterson,
- Belleville,
- Linden,
- Marlton,
- North Bergen,
- Princeton
Catholic Dating By Diocese:
- Archdiocese of Newark,
- Diocese of Camden,
- Diocese of Metuchen,
- Diocese of Paterson,
- Diocese of Trenton


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Jessica Alba to join Thomas Jane in "The Veil" horror
February 15, 2014 - 11:32 AMT
PanARMENIAN.Net - Jessica Alba is in negotiations to join Thomas Jane in The Veil, the latest microbudget horror film from Jason Blum's Blumhouse, The Hollywood Reporter said.
Phil Joanou is on board to direct the pic, which has a script by Robert Ben Garant, a co-writer on the Night of the Museum movies who also wrote Jessabelle for Blum.
The Veil's story revolves around members of a religious cult known as Heaven's Veil who take their own lives. The truth behind what really happened remains buried deep in the memory of the sole survivor, a five-year-old girl, who returns to the compound with a documentary crew as an adult. They soon discover something that is far more terrifying than anything they could have imagined.
Alba will play the documentary filmmaker who accompanies the survivor back to the compound to investigate what really happened.
An April shoot is being eyed.
Alba already worked with Blum on Stretch, a thriller starring Patrick Wilson and Ed Helms. She recently completed the action comedy Barely Lethal for Kyle Newman and has Sin City: A Dame to Kill For in the can. She is repped by CAA, 3 Arts Entertainment and Sloane Offer.
Blum next releases Oculus, the supernatural thriller with Katee Sackhoff and Brenton Thwaites, which opens April 11.
Top stories
With an estimated $1 billion in annual sales, Gagosian works across various eras, represents living artists like John Currin and Mark Grotjahn.
Tigran Hamasyan was named International Instrumentalist of the Year, Piano, for his Nonesuch Records debut album, Mockroot.
This will be an exceptional and rare opportunity to showcase the Republic of Armenia and Armenian arts in the United States.
Nazarian will present "I Hate Dogs" by Suzanne Khardalian, a film about one of the last Genocide survivors residing in France.
Partner news
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Japanese PM Abe to visit Russia next week An announcement said Putin would host Abe next Friday in Sochi, the Black Sea city where the 2014 Winter Olympics were held.
Armenian khachkar destroyed in Arizona The architect of the church, said, "It feels deliberate because it's a terrible coincidence that this happened during the week of April 24."
600 kilos of Roman coins found during routine work in Spanish town "It is a unique collection and there are very few similar cases," Ana Navarro, head of Seville's Archeology Museum said.
Yemen warring parties begin direct peace talks in bid to end conflict: UN "All delegations are present. Key issues will be addressed," Charbel Raji, spokesman for Yemen's UN envoy said.


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Dunkin' Donuts, in a bid to catch up to the technology prowess of Starbucks Corp., is testing on-the-go ordering and delivery service in some U.S. markets. more
By Leslie Patton
The cost of living excluding food and fuel rose again in October after picking up the prior month, showing inflation edging closer toward the Federal Reserve's goal. more
By Michelle Jamrisko
Benrus will be throwing its hat into the ring during the holiday shopping season with the opening of a retail store on Nov. 19 at 10 a.m. at 39 Pike St. more
By Chelsea Boulrisse
Self-serve, regular unleaded gasoline fell a penny in Rhode Island and Massachusetts from last week, AAA Northeast said. more
By PBN Staff
A.B. Munroe Dairy Inc. will be recognized as the 2015 Business of the Year by the East Providence Chamber of Commerce. more
By PBN Staff
Sales at U.S. retailers rose less than forecast in October as consumers pocketed the money saved after fueling up their cars. more
By Michelle Jamrisko
Black Friday's death has been greatly exaggerated before. This year, not so much. more
By Lauren Coleman-Lochner and Lindsey Rupp
Demolition of the original interior space at the Rhode Island Mall has begun, a process that is expected to take at least three to four months. more
By Mary MacDonald
Reversing a downward trend, prices of self-serve, regular unleaded gasoline jumped 3 cents in Rhode Island and Massachusetts this week, AAA Northeast said. more
By PBN Staff
On the heels of a healthy August, September's economic momentum in Rhode Island fared almost as well, according to University of Rhode Island economist Leonard Lardaro. more
By Patricia Daddona


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How much does it cost San Francisco to clean up the homeless feces that piles up day after day at every street corner.
It is possible that the democrat floosy wanted to get raped by middle east muslim terorists but didn't expect to get killed by the evil skumbag middle east muslim geehawdeez.
JIMMY CARTER IMPORTED CUBA'S PRISON POPULATION, OBAMA IMPORTING SYRIAN TERORISTS why do democrats always want to lowest lowlife garbage into the USA?
OBAMA EPA ALLOWED FORD MOTOR CO TO DUMP LEAD CONTAINING TOXIC WASTE IN FLINT FOR NEARLY ONE DECADE. Ford is notorious for dumping millions of gallons of toxic paint sludge full of lead, benzene arsenic and chromium in Michigan in various locations including flint.
Ford dumped its toxic heavy metal waste into the woods of indian tribes. Obama's EPA tried to wipe out the Navajo Indians by dumping 3 million gallons of Arsenic (rat poison) into the Animas River the main water supply for the Navajo Indians. Obama Admin didn't care that the Animas River carried the arsenic into the drinking water of 5 US states. Collateral damage was no concern to the Obama EPA.
Obama's EPA and Obama's Fish and Wildlife Dept allowing billions of gallons of toxic oil sludge to completely saturate the US Gulf Coast killing thousands of endangered wildlife species and forcing the poor to eat toxic oil soaked Gulf Coast fish. Cant get more evil than Obama's EPA and Obama's Fish and Wildlife Depts.
OBAMA EPA WORST THAN FORD WHEN IT COMES TO DUMPING TOXIC WASTE. OBAMA EPA DUMPED 3 MILLION GALLONS OF ARSENIC into the Colorado Animas River which carried to rat poison to 5 different states (Colorado, New Mexico, Utah, Arizona and California and even Mexico). The obvious target of this ethnic cleansing attempt is the Navajo Indians who heavily use the Animas river for daily living.
DEMOCRATS WOULD HAVE ALL OF USA DRINKING OBAMA EPA ARSENIC POISONED WATER. OBAMA EPA gave the green light to dump 3 millions of Arsenic (rat poison) into the Colorado Animas River which traveled to 5 states.
The uk evacuated their bengazi workers. hillary let usa workers be murdered then blamed a youtube video
Obama said terorists would not get into usa because he is vetting them. he vetted muslim terorist tasfeen malik and she killed 15 americans at san bernardino. obama also vetted the tsarnaev brothers and gave them welfare and citizenship and they promptly bombed the boston marathon.
AMERICANS AGAINST OBAMA IMPORTING MILLIONS OF MUSLIM TERORISTS INTO USA AS REFUGEES. Those maddog killers can stay in the middle east killing each other. The world would be a much better place without them.
For once you are right. Need to clean house in the Senate and House and replace all the establishment traitor GOP skumbags (McConnell, Graham, Ryan and their allies) with Tea Party Patriots. Having these establishment turds is like having an army of benedict arnolds on your team betraying you at every turn and joining the opponent at every turn.
Agree Ryan and McConnell and their traitorous allies all need to be replaced with Tea Party candidates. These skumbags (McConnell, Ryan and their allies are always implementing Obama's agenda fk em all).
FORD WONT TALK ABOUT ITS TITANIC LOSSES IN SOUTH AMERICA, QUITTING JAPAN AND INDONESIA BECAUSE THEY CANT COMPETE THERE RECENT GIGANTIC RECALL ON EXPLODING FORD AIRBAGS IN RANGERS ECT. Unfortunately for Ford UAW trolls on this msg board investors can find this information all over the internet.
Wsj - yahoo to cut 15% of jobs close several units layoffs everywhere in the near horizon
Cruz is the only Constitutional Scholar running for POTUS.
SKUMBAGS LIKE RYAN AND MCCONNEL who always join democrats to implement the democrat party agenda ARE THE GOP's biggest problem.
Nutty tin foil hat clinton fans want karl marx for vp. usa biggest problem is low iq idiots like clinton supporters
Veterans to the front of the benefits line. Foreign illegal alien criminals and muslim terorists imported into the USA by demoncrats to the back of the line (an if establishment GOP replaced by tea party patriots) illegal aliens and muslim terorists get rounded up and deported then are denied benefits and entry into USA permanently.
UAW SKUMBAGS WETTING THEIR PANTEEZ IN TOTAL HORROR THAT TRUMP COULD WIN. They try to portray Trump as a silly cartoon buffoon that cant win but attack him 24/7 and are in horror that their hateful vicious attacks are getting ZERO TRACTION. They are despately cheerleading for Kasich and Bush but nobody cares.


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Best fish and chips shop in the redcliffe area
Foursquare © 2016 Lovingly made in NYC & SF
Nantucket Kitchen & Bar
Seafood · $$$
Indooroopilly Shopping Centre (Station Rd)
"Highly recommend the Sirloin here. Amazingly tender and full of flavour!"
33 Caxton St
"Divine -wonderful fresh food and top service"
Seafood · $$$$
249 Turbot St. (Sofitel Brisbane Central)
"Explore the Flavours and Spices of Asia. With a fresh twist on traditional Asian cuisine the buffet offers an innovative blending of Vietnamese, Malaysian, Chinese and Thai dishes."
Make sure your information is up to date. Plus use our free tools to find new customers.
Download Foursquare for your smart phone and start exploring the world around you!


text:
We expose slave masters and people smugglers in suburban Britain.
Is there more to life than money?
29 Aug 2012 17:57 GMT | Latin America, Mexico
Archeologists in Mexico city have found what they say is the skeleton of a young woman belonging to the Aztec nobility.
Rocio Morales and her team discovered the remains five metres below ground in Mexico City's Temple Mayor.
Altogether nearly 1,800 bones were uncovered, believed to be the remains of seven adults and three children.The unprecedented discovery is the first evidence of mass sacrifice, or reburial of remains, for a member of the ruling class in the Aztec empire. Morales said: "It's really exciting to make this kind of discovery and be so lucky to to be the first one to dig it up and register it."
Al Jazeera's Rachel Levin reports from Mexico City.
Source: Al Jazeera
Archaeologists have discovered a home dating back to the era of Jesus Christ.
Middle East
Last speaker of ancient language dies, breaking link to 65,000-year-old culture.
Some say they extort money, but franeleros insist they are just trying to make a living in Mexico's informal economy.
Will a plastic bag levy be enough to fix Indonesia's rubbish problem?
For ethnic Hausa, the traditional form of boxing known as dambe is more than a sport - it is part of their identity.
Nigeria, Sport
Rape is Malawi's most reported crime. Ujamaa initiative is helping schoolkids defend themselves against perpetrators.
Malawi, Africa, Women
Qatar calls for emergency session while opposition group labels Assad government's onslaught "crimes against humanity".
Syria's Civil War, War & Conflict, Russia, Middle East
Opposition politician promises no compensation and pledges to nationalise banks if his EFF party wins local polls.
Politics, Africa, Julius Malema, Elections, South Africa
We examine how cyber thieves are hacking the world's financial architecture and why it's not just about money.
Business & Economy, Science & Technology, Crime
We follow the journey of Kenyans seeking justice for Britain's role in the torture during the 1950s Mau Mau uprising.
Kenya, United Kingdom, Africa
People & Power investigates the environmental consequences of palm oil plantations in equatorial Africa.
Environment, Africa, Cameroon
Five years on, Misratans reflect on the siege of their city and how it played a role in the downfall of Gaddafi.
Libya, War & Conflict, Muammar Gaddafi


text:
Friday, September 26, 2008
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Designers, marketers, engineers, and meme-lovers alike will fawn over the new Adobe Image Editor in HipChat. Instead of uploading and downloading images all day, you can now edit and create beautiful images right inside of HipChat using the power of Adobe. And that is some serious muscle.
Archive for the 'Integrations' Category
Adobe Image Editor: Edit, enhance & meme-ify images in HipChat
New to HipChat? 3 first steps to get started
If you're a HipChat newbie, welcome! We're super (content) to have you aboard. HipChat is easy to use and set up, so don't worry about reading tons of boring instructions. Just do these three steps, and you'll be smooth sailing.
35 new ways to do your work right inside of HipChat
Engineering, Operations, Support, Marketing, and Business teams – There is no other tool that lets you do as much inside of chat as HipChat.
Six months ago at Atlassian Summit, we introduced our new integrations platform powered by HipChat Connect, allowing developers to build apps that run inside of chat. Today we're thrilled to see over 35 new integrations in the HipChat marketplace that let you do more inside of chat than any other tool.
HipChat video integrations now include BlueJeans & HYFY 🎥
Modern team communication is all about freedom—freedom to work where, when, and how you want. While only a few years ago it was a challenge to work remotely, today the idea of working on a beach in Bali doesn't raise an eyebrow. HipChat makes this possible.
For remote teams or workers, the power of face-to-face communication can often be what's needed to keep everyone in sync. For these times, HipChat video and video integrations are there to help.
Lucidchart for HipChat brings your flowcharts into your workflow
You can type your heart out, but sometimes the best way to get a point across is to show a visual. Flowcharts help teams organize thoughts, projects, and organizational structures, and Lucidchart, an easy-to-use flowchart and diagramming tool, is your ticket to helpful visuals land.
Plus, with the new Lucidchart for HipChat integration, your flowcharts and your workflows are one. HipChat is where your team is working, so just like sharing files, now your team can share collaborative charts.
HipChat Bots: A guide for the humans
HipChat bots, or "HipBots" as we call them, have long been a HipChatter's best friend: loyal, dutiful, and, if we do say so ourselves, adorable. Each bot is gifted with its own unique skill, helping your team stay organized and do its best work. Better yet, they're easy to install and happy to work 24/7. Explore all our bots here. Learn about four of our favorites below.
When 💩 hits the fan, companies manage incidents with StatusPage & HipChat
💩! There's a hiccup with your service. You jump into incident-management mode. Your users, who are already tweeting and sending support tickets, need to know what's up. Your team needs to come together to diagnose and fix the issue. And all this needs to happen fast.
Be gone, browser! Welcome Cloudo in HipChat
The cloud's ability to store infinite amounts of information has given us so much – but it also creates "cloud clutter." At first you used just a few cloud services, say Gmail, Dropbox, and Trello. But fast forward a few years, and you're probably using tens of services in the cloud to get your work done. And that means all the files that are most important to you are scattered and difficult to find.
Cloudo changes that.
Inside Atlassian: How IT & SRE use ChatOps to run incident management
Any team that slings code for a living deals with service issues. They know all too well the hated red alert… the dreaded text in the middle of the night… the loathsome ping from a coworker telling them that $#!π just hit the fan. But what separates good services from great services is the ability to recover swiftly with minimal affect on users. And a big factor in swift recovery is ChatOps.
What is ChatOps? A guide to its evolution, adoption & significance
I am the product of AIM. I can hear that door swinging open and closed in my mind with absolute fidelity. I know that ding like I know the sound of my own babies crying.
At 15, as I typed away into AOL IM, I never imagined that chat could turn into a tool powering some of the greatest innovation in business, technology, science, and beyond. There's even a name for this phenomenon: ChatOps.


text:
Shin Bet apparently tracked the package after wondering at an enormous quantity of salt ordered by a Gaza importer with Hamas ties.18:10 03.05.16 | 0 comments
I understand the Israeli need to intercept this flotilla. They need to save face. Of course, the flotilla could be inspected at their last port of call, and monitored all the way to Gazan waters. There is great technology to make sure nothing is added to the ships. The main issue here is that Israel must have total control, but hopefully when they stop it--and they will, they will not do it in international waters like the last time.


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Real news. Real funny.
It's Not News, It's Fark
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Diesel Mechanic Jobs Forum
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Current Discussions (158) - Start a Discussion
Mango in Manchester, United Kingdom
Gear stick extension - Iveco Daily
Hi, I have a 2000 Iveco Daily. The gear stick is way too low down and gives me shoulder ache as I actually have to lean over to get 1,3 and 5. Is it...
Dr. Goodwrench in Aliso Viejo, California
DT 466/530 conversions to Natural Gas
AnyOne worked on one these yet or heard of any issues,
Jersey Joe in Denver, Colorado
Updated 51 months ago
2005 DT466E Fuel in Oil - 1 Reply
Working on a 2005 International School Bus with a DT466E around 88,000 Miles. Getting fuel in the oil. I am suspecting the injectors, Anyone run in...
umerhayat in Abu Dhabi, United Arab Emirates
Updated 51 months ago
mechanic jobs in france - 1 Reply
looking for a job in the south of france{borbeaux}area,i`m a fully quailified plant/truck mechanic/and have a good back ground experience ranging...
Catfarmdude in Bury, United Kingdom
Iveco - lack of power
Hi Everyone! I have a 35c12 on a o4 plate. For some reason it seems to be lacking power. It runs ok, starts fine, if a little sluggish, but just does...
jmr63301@*****.*** in O Fallon, Missouri
Updated 52 months ago
1993 Ford E350 7.3 Diesel - 2 Replies
Have a 1993 Ford E350 diesel Bus.... It never starts right up it takes some time. It will crank over then die immeidately then won't start for a...
jmr63301@*****.*** in O Fallon, Missouri
Updated 52 months ago
1996 e 350 7.3 powerstroke - 1 Reply
my box truck starts runs fine then go down the hwy about 55 at steady speed and start slowly loseing power if i keep going it will eventually die but...
@vw in Los Angeles, California
Updated 53 months ago
1999 international 4700 6 cyl deisel - 2 Replies
Going through 6 liters of oil a day but showing no sign of burning it . Checked turbo and compressor no sign of oil build up . Could it be rings but...
Cadburyegg in Winner, South Dakota
Updated 53 months ago
complete set of tools - 4 Replies
I have no idea, if I am posting this correctly!! forgive me if I am not suppose to ask this.. but my husband changed careers a few years back, and...
kenny in Dover, New Hampshire
Updated 53 months ago
Top diesel mechanic skills needed to get the job. - 20 Replies
What are the top 3 traits or skills every diesel mechanic must have to excel? Can you suggest any tips or insights to develop your diesel mechanic...
grobinson in Vacaville, California
Updated 53 months ago
Work - 5 Replies
Im a certified Diesel mechanic looking for work desperatly .
Confused in Normal, Illinois
Updated 54 months ago
02 International DT466E- Hard to start - 2 Replies
I have an 02 International 4300 with the 466E. When the truck sits for more than a few hours, it cranks for a long time before it starts. The...
Fabio in Shelton, Connecticut
Portable Aurora diesel generator
I am looking at purchasing a 6500W portable diesel generator from Aurora. I wouldlike some feedback as to the quality and reliability of units they...
Updated 55 months ago
How hard is it to get your foot in the door??? Going to get degree in Diesel Tech at 2 year college - 1 Reply
Starting school pretty soon, i'm interested in working as a fleet mechanic in a large scale trucking company, looks like they are some of the best...
ehsanullah qazizadah in Afghanistan
Updated 55 months ago
1998 International - 1 Reply
Just replace a fuel pressure regulator, drove the truck for 1 day-sputtering at 1800 rpm any ideas before I go back to the repair shop? DT 466...
International_certified_2011 in Mckees Rocks, Pennsylvania
Updated 55 months ago
water still leaking in engine - 2 Replies
1990 International, 360 Engine. After having the piston head resurfaced and leveled as well as a valve job, water is still pouring into the oil pan. ...
KevinMul in United Kingdom
Iveco Eurcargo 2001/2002 blink codes
Can someone please direct me to where I can purchase or get a manual that has a list of all the blink codes, Thanks in advance.
shoprat in Pasadena, Texas
24 volt in a 12 volt truck
anyone on here ever run across a meritor freedomline transmission? its a 24 volt unit in a 12 volt truck but what i am wanting to find out is how...
Phil Bock in Tyngsborough, Massachusetts
2001 dt466e runs like hell
the truck runs terrible and have hadit to every shop in town no visible codes but they clear the computer. and truck runs exellent for about 2 hours...
Mike in Pickens, South Carolina
nuetral safety switch 1999 international 4700
I have an International 4700 truck that the breaker is being tripped. It controls the neutral safety switch. When the breaker trips, the engine...
ajhd in Salt Lake City, Utah
Updated 57 months ago
DT466 shutdown no codes - 3 Replies
I have a truck with a DT466 "05" . The engine spits and sputters after 20-40 miles . It will shutdown. Wait 15mins and it will start back up and run...
FAF in Houston, Texas
Truck shakes at speed 40-55 .i mean shaking kinda sideways.i dont feel much vibration on steering wheel,i do feel it when i hit the brakes.(have air...
williansanthony in Kingston, Jamaica
Updated 58 months ago
Ford Iveco 75E15 wiring diagram - 1 Reply
Hi all and thank you for reading. Can anyone tell me where I can obtain a wiring diagram for the above vehicle. Thank you in anticipation. Tony
Jan in Male Kysice, Czech Republic
Iveco Daily 2007 Diagnostic tools
Hi, what would you recommend for Iveco Daily diagnosis? Iveco Easy is not affordable for me, the only option I have found seems to be...
TheRookie86 in Indianapolis, Indiana
Updated 60 months ago
Is a career change to a diesel mechanic a good choice - 2 Replies
I am 39 changing careers. Is diesel mechanic a good idea?
MusicMan in Shaftesbury, United Kingdom
Iveco Daily Electronic Sliding Door, it wont close! cash waiting for someone who is an expert on these doors
Hello Everybody i just joined this forum :D i have an X registration (year 2000) Ex Parcel Force Van and yes, the date is correct, even though...
schmittm in Kennewick, Washington
Updated 61 months ago
Vt365 (6.0) 2008 shut down after 2min of idle, won't start or tunrover - 2 Replies
Started 2008 vt365 in 4200 chasis yesterday and after 2 minutes it shut down. Now won't start or turnover. Can hear clicking sound behind dash on...
transis123 in United Kingdom
loss of power
Any 1 help iv got a transit 2.5 td 1996 u can drive it with lots of power turn it of then turn it back on then it will lose power please any info
WILL in Garden Grove, California
Updated 62 months ago
6L Powerstroke problem - 2 Replies
Hey all, I've got an 04 Ford F-350 with the PSD and have had the issue of puking coolant from the degas bottle. First had it happen in Dec '07,...
tony j in Dowagiac, Michigan
Updated 62 months ago
diesel mower wont start - 1 Reply
Ya I've got an old jacobson zero turn 3 cyl. Diesel mower. Having a lot of problems getting it to start. Broke the injectors loose and it appears to...
kennystreetsparkplug in Dover, New Hampshire
Updated 62 months ago
cant find work as adiesel mechaic - 1 Reply
forthe 6years ihave been trying to find work as a diesel mechanic but no one to will hire me ihave had training in the ary national garud and...
1997 International DT466 spits and sputters
truck will run fine and after 50 miles or so will shut down, wait a bit and now it starts but spits and sputters really bad and keeps dying, I...
daveyboy in Todmorden, United Kingdom
iveco dailey 35s13 gearstick play
i have an iveco dailey 35s13 and it has mega play in the gear stick , i can get all the gears its just there dificult to find sometime , im getting...
tim in Longmont, Colorado
Updated 63 months ago
Is there an easy way to get dual wheels off of a truck? - 1 Reply
Is there a way to get dual wheels off of a truck? I work on a lot of big trucks is there a better way to get them off other than that big expensive...
goldie1b in dunoon, United Kingdom
Hi can anyone out there please tell me what fittings i need to replace brake lines on a iveco daily 29L 2.3 10hpi, I plan to use 3/16" copper bundy...
Keith downs in london, United Kingdom
Iveco Daily 35S12 "x reg" fuel pump problems
hey all, slightly OT reply but here goes. i own a 35S12 hpi on an "x reg...2000" it was running lovley then it basically justt stopped.there was...
sharpy in Turkey
Updated 64 months ago
iveco daily not starting from cold - 8 Replies
iveco not starting from cold just had fuel filter and pump fitted and not made any difference. if i take the thermo fuse out and thermo relay it...
mike in Apopka, Florida
Updated 65 months ago
need some guidence - 2 Replies
i am interviewing for an equipment mechanic apprenticeship job on the 19th of nov. and want to be on my game. i am inexpereienced in the interview...
48036 in Plymouth, Indiana
Updated 65 months ago
Tips for diesel mechanic interviews. - 2 Replies
Do you have any tips to help prepare for an upcoming diesel mechanic interview? Are there common interview questions that come up again and again?
kickenit2 in Phoenix, Arizona
Updated 65 months ago
Diesel engine swap - 5 Replies
I would like to know if it would be worth it to put a 1978 3.9 cummins motor into a Chevy 3500 P/U. Also wondering what the cost would be for someone...
Dan Brown in Wallsend, United Kingdom
Iveco Daily 2008 3.0hpi
My iveco wont stop running if the head lights are on. If i take the key out it will still run. Has anybody had this before
chase lunn in Mobile, Alabama
international 4300
anyone have codes for 2003 international 4300 my truck is throwing fault 150: 1 2023 14p
Brian in Breckenridge, Texas
Updated 66 months ago
6.0L diesel F250 - Fuel Pressure Regulator leaking - 1 Reply
I noticed a fuel smell coming inside the cab during stops but not while cruising. When I got home I noticed the fuel pressure regulator was leaking...
pig tail in Myrtle, Mississippi
Updated 66 months ago
dashboard is not working - 1 Reply
my dashboard on my 99 international dt466 is not working
Wayne in Akron, Ohio
1987 S1900 International DT466C No Start
Both tanks are new and full of fuel. new fuel filter and was running fine then it died about 300 miles from home on the owner and I went down to...
ukremovals in Cumbria, United Kingdom
Updated 67 months ago
Iveco daily 35c14 - 1 Reply
Hi,Im a rear axle for an iveco daily 35c14 xlwb. mine is a chassis cab version, not a van.Also it's a 2005. thanks mike.
Benjamin Magdaleno in El Paso, Texas
need major help PLEASE
ok so i have a yanmar APU model 2TNV70-KBR it wouldn't start I found out the transfer pump wasn't working so I replaced it, but not before I...
So Fresh in Durham, Connecticut
05 IH 4300 / DT466 wiring harness issue
We just recently swapped in a brand new DT466 engine for this 05 4300 with a manual transmission. Everything internally was ripped apart, real bad...
brian varnes in Thousand Oaks, California
physical Aspect of job
Ok, Im a 34 year old man who was involved in a horrible motorcycle accident 3 yrs ago.Because of this, I have lost my trade in sales due to my voice...
Mover in Elgin, Texas
Updated 68 months ago
Dt 466 - 3 Replies
I have a 2004 international 4300, DT466. The fuel tank on the driver side does not switch over. Its like it is not there. I have fill up this tank...
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A super cute lightweight tote to fill with some goodies for someone you love. Personalize however you like. These little numbers would be a wonderful cost effective option for welcome bags. To top it off with a cherry they are only $5! They started out as a closeout item, but the demand has been crazy so we are bringing them back! Get yours while the getting is good.
Your Wedding Experience Presented by David TuteraPosted:
your wedding experience
Find your wedding planning perfection at a wedding show like none other! Your Wedding Experience presented by David Tutera has a wedding catwalk, project wedding dress, nominate your fiance to model the men's wear, celebrity appearances, and much more!