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Cutesy Zebra Rainbow Swirl Lollipops
Personalized Rainbow Swirl Lollipops
Hand out the cutest and most delicious zebra print favors.
Personalize these Cutesy Zebra Rainbow Swirl Lollipops with your custom message. These lollipops feature a stylish zebra print design and a polka dot border. Hand these Cutesy Zebra Rainbow Swirl Lollipops out to your guests and watch them go wild!
Personalized Swirl Lollipop features:
- Free personalization!
- Your design choice is printed on the included 2 inch sticker.
- 2.4 ounces.
- Approximately 2 3/4 inches in diameter (diameter may vary slightly) x 7 1/2 inches long.
- Fruit flavored.
- Choose rainbow or white swirl.
- Assembly required.
Please allow ample time for delivery. Our ship date for this product is noted in your shopping cart. Many items are shipped separately, so please allow extra time for these items to arrive. Shipping charges are based on the value of the merchandise and not the number of shipments. For additional shipping information, please contact our Customer Service Department at (email@example.com or 1-800-314-8794).


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silly Amazon ads
Started Apr 25, 2014 | Discussions thread
Shop cameras & lenses ▾
Senior Member • Posts: 5,248 • Gear list
silly Amazon ads
Apr 25, 2014
Amazon appears to be slightly confused. Today on these forums, where I usually see the general ads for Amazon Gift Cards, I have been seeing ads for Canon fast fifty lenses, primarily the EF 50mm f/1.4 USM. I am sure this is a nice lens, but not really something I am in the market for. Unless somebody out there wants to send me a 6D to put it on ... and even then I probably would prefer a 35mm/ 85mm tandem.
Do the Amazon ads ever try to sell you something you don't really want?
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Simulation of an Orthogonal Frequency Division Multiplexing Based Underwater Communication System Using a Physics Based Model for the Underwater Acoustic Sound Channel
AUTHOR: Pittman, Gell T., III
PUBLISHER: Storming Media
Also available at Amazon.com
This book is not guaranteed to come with supple-
mental materials (access codes, CD's, DVDs, etc.)
mental materials (access codes, CD's, DVDs, etc.)
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Course Requirements 2015: 2015 UNDER CONSTRUCTION!
- Paper 1 (5 page) 20%
- Paper 2 (10 page) 25%
- MidTerm Exam 20%
- Final Exam 20%
- In-Class Quizzes : 10%
- Discussion Group : 5%
One five-page and one ten-page research paper are required. Before you begin writing your paper, you are required to turn in a one page Outline that outlines the topic you will be addressing. In your Outline, you should also include a preliminary list of references.
Outline Due: Final Draft Due: Paper 1 Wednesday, April15, 2015 - 2:00 pm Wednesday, April 22, 2015 - 2:00 pm Paper 2 Wednesday, May 13, 2015 - 2:00 pm Wednesday, May 14, 205 - 2:00 pm
Paper assignments will be distributed in class.
Paper 1 Assignment: 5 Page Assignment (Papers should be about 5 pages (5-7) excluding figures, endnotes, and bibliography. A separate page with bibliography of sources is required.
Outline & Sources due: April 9, 2015 (Wed) 2:00 pm -
- via Email to your TA
- upload to Canvas
Final Draft (5-7 pages) due: April 22, 2015 (Wed) 2:00 pm
- upload to Canvas
- deliver Hardcopy to Mary Moul, Cummings 227C at Thayer School
Paper 2 Assignment: 10 Page Assignment (Papers should be about 10 pages (9-12) excluding figures, endnotes, and bibliography. A separate page with bibliography of sources is required.
Included please find the rubric that we'll be using for grading the second paper. Good luck with your research. We look forward to reading about your great ideas.
Outline & Sources due: May 13, 2015 (Wed) 2:00 pm
- via Email to your TA
- upload to Canvas
Final Draft (9-12 pages) due: May 20, 2015 (Wed) 2:00 pm
- email file to Mary Moul (email)
- deliver Hardcopy to Mary Moul, Cummings 227C at Thayer School
Your TA should be helpful in answering any questions you may have about the assignment. If you have additional questions, please contact Prof Robbie email.)
Late papers are strongly discouraged. A late paper will lose one full letter grade for each day it is late. Any paper turned in more than three days late will not be accepted. If you have a legitimate problem or medical excuse, please contact Prof Robbie email.) as early as possible for accommodation.
Recommendations for Paper Writing -
Good writing reflects both organization and imagination. Papers in ENGS05 tend to become complex due to the diverse topics that you'll need to explore. To help maintain good organization, you are strongly encouraged to:
• Create an outline before you begin writing,
• Use outline topics as headings to organize your paper. For simplicity you may wish to use the grading sections of the enclosed "Grading Rubric" as major headings for sections of your paper.
• Use the paragraph as unit of organization.
Research Resources:
Please consult the custom web research guide for Engs05 developed by Feldberg Library:
Library Research Portal :
Format Requirements:
We recommend that you use text format that includes frequent bold headings along with standard citations (either footnotes or endnotes are acceptable). Papers should be about 5 pages (7 max) excluding figures, endnotes, and bibliography. A separate page with bibliography of sources is required. Please use line spacing of 1.5, standard margins, and 11pt or 12pt type.
In the outlines you should explain:
- The topic you are going to address.
- Why you chose this topic
- The approach you are going to take to address this topic.
- List of Sources you intend to use
Class Use of Laptops / Electronic Devices:
Use of laptops and other electronic devices is not allowed during lectures because they provide a barrier between instructors and students. All lecture slides and lecture videos will be posted on Blackboard so exhaustive note-taking is not required.


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Viarex Overview
Viarex is a topical cream that is designed to enhance the size of the male penis significantly. It is only available from the internet, directly sold by the Viarex Labs company who have a website that is very unprofessional in appearance. The site is basically one long page containing a 'personal' letter from one of Viarex's owners, although there are separate sections with an informative FAQ page and 'how it works' details. Despite the seemingly large amount of information, there are no details regarding the actual ingredients in the formula which the manufacturer says is superior to all other methods of penis enlargement on the market, including surgery and oral capsules (usually the preferred method).
Consumers are shown a chart explaining what they can expect to see in terms of results, week by week, and there is a secure ordering section and protection plan information. A 15-day amount of Viarex costs $39.90 and there is a 30 day buyer protection safeguards.
Viarex Product Details
All that is known about the Viarex formula is that it is a natural, plant-based blend which should be applied and massaged into the penis. The formula likely contains a number of substances that improve* and stimulate the blood flow, allowing a greater amount of blood to fill the penile chambers. The manufacturer states that the subsequent increase in penis size is lasting but do nothing to prove this and, according to experts, not even possible. Most formulas of this type will use Tongkat Ali, Ginseng, Prosexual Nutrient amino acids and Caltrops to benefit male virility and sexual energy, but how effective they would be when simply applied to the penile skin is not known.
Advantages of Viarex
- Viarex has a buyer protection safeguards.
- The website has a FAQ section.
- The ordering process is secure.
- Manufacturer contact details are provided.
- Customer user experience stories are shown.
Disadvantages of Viarex
- No clinical evidence of results are shown.
- Viarex is expensive.
- Ingredients are not listed.
- The product website is unprofessional.
Viarex The Bottom Line
Viarex is not a product that can be recommended to male consumers. There is no evidence that a topical cream such as this can increase penis size in any lasting way, although a greater flow of blood to the penile chambers may temporarily improve* the firmness and endurance of the erection. Even with a 30-day buyer protection safeguards it is not worthwhile ordering the Viarex cream, particularly when it is not even known what is in the formula.
Our Top 10 Male Performance Products
Our Top 3 Male Performance Products
Enhance Your Results: Take a Comprehensive Approach to Improve* Your Sexual PerformanceSupplementation on its own can help with some sexual issues, but following the tips below as well will ensure peak performance between the sheets. They are also useful if you want to improve* your overall health and well-being. To be at your best:
- Get Plenty of Sleep (eight hours a night if possible): You already know how you feel when you skimp on your sleep. You have no energy and you're always wishing you could sneak off for a nap. Nobody is interested in sex when they feel this way. Get more sleep for an instant libido support.
- Eat Well: That means eating low-fat, high-fiber foods and ones that contain complex carbohydrates. Being at your ideal weight and consuming fresh foods will both assist in improving* sexual function.
- Stop Stressing: Some level of stress is inevitable, but too much can literally wipe out your sex drive and result in erectile difficulties. Try stress-reducing activities and avoid unnecessary stressors in your life to improve* your mental and physical health and your sex life.


text:
Pronunciation: /ˈsɪs(ə)l/
Definition of scissel in English:
noun[mass noun]
Clippings and strips of waste metal produced during the manufacture of coins.
Early 17th century: from French cisaille, from cisailler 'clip with shears'.
Words that rhyme with scisselabyssal, bristle, epistle, gristle, missal, thistle, whistle
What do you find interesting about this word or phrase?
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= trending


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Why President Eisenhower Represents the Right Model for GOP Revival
It's true that the American people are fundamentally conservative – but not in the angry, doctrinaire sense suggested by so many of my fellow radio ranters. Americans are conservative in temperament, but not necessarily in ideology. We are cautious, practical, skeptical folk, inherently resistant to sweeping, radical change—whether such change issues from the left or the right.
At the moment, the liberal true-believers who control both White House and Congress present the most potent, plausible threat of precisely the sort of jarring and dangerous transformations the people reliably reject. This offers Republicans a precious opportunity to re-connect with America's deep-seated conservative instincts and to revive their battered party – unless they blow that chance with strident, unbending, purist appeals of their own, convincing the puzzled public that both parties have abandoned pragmatism and common sense.
Formulas for Victory, Prescriptions for Disaster
Recent political history shows a clear and consistent public preference for flexible problem solvers over embattled ideologues. For some fifty years, presidential elections have been mostly close – with ten out of the thirteen winners held to 54% or less of the popular vote (and five of them actually winning with less than a majority). Only three times since 1960 did candidates win in one-sided blow-outs, and in each of those races (LBJ's triumph in '64, Nixon's in '72, and Reagan's in '84) the opposing nominee looked like an impractical, reckless, wing-nut extremist. Barry Goldwater even embraced the title extremist ("extremism in the defense of liberty is no vice"), George McGovern's anti-war crusade offered an unapologetically leftist platform, and Walter Mondale proudly promised in his convention speech that he would raise the nation's taxes. Their pathetic performance as major party nominees (winning 39%, 38% and 41%, respectively) showed the powerful national reflex against any candidate or party perceived as out of the mainstream, tilting too far in one direction or another.


text:
Contact: Megan Fischer Director of Communications (401) 273-5437 ext. 126 email@example.com New ThinkSpace Exhibit Opens November 10 at Providence Children's Museum … more
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Contact: Michael Beauregard / Associate, Rickman Group 401-421-0606 / firstname.lastname@example.com "Future Trends" Conference Renews Conversation on Medicaid Services for Rhode … more
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The Warwick, RI Express Employment Professionals office earned top honors at the international staffing firm's SALES Summit regional meeting held Sept. 28-29 in Hasbrouck Heights, N.J., according … more
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PROVIDENCE, R.I. — The Ocean State Chapter of the Project Management Institute (PMI) will hold its monthly chapter meeting on November 8th at the Sheraton Airport Hotel, 1850 Post Road Warwick, RI … more
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Cranston, RI, October 24, 2012: Perfect Touch Interiors (PTI) announces new ownership. Established in 1983 by Ms. Lori DelSesto, PTI's new owner and President is Ms. Manuela Mauss Montaquila. Ms. … more
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EAST PROVIDENCE – In honor of National Breast Cancer Awareness Month, Rhode Island Medical Imaging (RIMI) contributed $10,000 worth of free services to the Rhode Island Department of Health's … more
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(Woonsocket, RI) Monday, October 22, 2012 –Consistent with Provider Group's (www.providerig.com) commitment to giving back to the communities in which clients and employees live, the entire staff … more
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Warwick, RI [Senior Care Concepts Inc.] – Jenny Miller, President and Owner of Senior Care Concepts is pleased to announce that Justine Stehle of Providence has joined the Senior Care Concepts team … more
By email@example.com | 10/23/12 09:23 AM
Andria Coletta, a partner in the Providence office of Taylor Duane Barton & Gilman LLP, has been invited to join the prestigious Claims and Litigation Management Alliance, a nonpartisan organization … more
By pboynton | 10/22/12 11:22 AM


text:
Duplex closes in Uptown
The 2006 and 2007 winner of the Best Restaurant for a First Date and famous peddler of poutine, Duplex Restaurant on Hennepin announced that after six years in business it is closing its doors for good.
The restaurant has yet to issue a press release, but neighbors of the Uptown establishment reported that owners posted a hand-written sign on December 15. The reasons for closing remain unclear at this point, but back in September the Hot Dish reported that Duplex, among others, had been fined by the city of Minneapolis for illegally buying alcohol. The restaurant was placed on a "liquor posting," preventing owners from purchasing any alcohol until they had paid back taxes.
Before announcing it would close, Duplex had offered a deal through Groupon that wasn't set to expire until March 2012. Groupon gives refunds for vouchers that could not be redeemed due to a business closing.
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Archive: May, 2008
Joseph N. DiStefanoThe Association for Corporate Growth's Philadelphia chapter, a local private-equity trade group, lists over 300 public and private offerings, mergers and acquisitions totalling over $60 billion in value for the first quarter of 2008. Link here.
Joseph N. DiStefanoThe Richter family-led multinational construction project manager, Hill International, Marlton, lands a couple more big deals: $5.3 million, over three years, at New York's City Hall (release here), and The Lighthouse, Dubai, $2.7 million (release here).
Joseph N. DiStefano
Comcast CEO Brian Roberts, at a Sanford Bernstein investor converence today, on last week's acquisition of Plaxo, operator of the Pulse social-network system, and other deals:
"A start-up company wants to work with somebody like Comcast. Take Plaxo for instance. They do (online) community, they do address book management. Well, we have 10 million address books, we have a community of 24 million people who do television. So OK, we see a convergence coming.
"These are leaders in that space, and innovators... So there's certain companies occasionally, these tend to be very small, that can help innovate inside our company and can help take us and lead the inovation we need to do in a competitive business. And so, that's the plan...
"Let's not concede web design, web creation, monetary gains, to every start-up. Let's try, in a modest way, to go about it (ourselves)... We've been building quietly about that notion. Fancast, our latest, anybody who wants to consume video on the Net, we have video relationships with every content company. Why not use that? Fancast got milions of users. It didn't cost very much to create. "
More on the Plaxo deal here:
Today's Webcast here: Plaxo, Fandango, small-business discussion starts around 33 minutes in.
Joseph N. DiStefanoTwo Spanish banks and Royal Bank of Scotland, owner of Citizens Bank of Pennsylvania, have agreed to finance the Albertis-Citigroup-La Caixa partnership that won bidding to buy the road, said Bloomberg News. Story here.
Joseph N. DiStefanoLeaders of the Philadelphia Stock Exchange, which has been purchased by Nasdaq, met for the last time Tuesday night in the garden of the Old City Tavern, where the market was organized as the new United States' first securities market in 1790.
On hand to mark the passing and clap politely for Mayor Nutter and other dignitaries were eight former PHLX presidents or chairmen. "It's a bittersweet night," said John Egan, who once compared the job of leading the chronically competitive and fractious traders to "running the Gladiators' Union in Imperial Rome."
"You know how Philadelphia is divided politically into 68 wards? We used to say the Exchange was the 69th Ward. The Fighting 69th," said Nicholas Giordano.
Egan, Giordano and their elders were united in praise of their final successor, Meyer "Sandy" Frucher, the New Yorker that exchange members and officers feared had been sent by the SEC to sell and close what had become the nation's smallest stock and options market when he took over 10 years ago.
When an initial sale plan blew up, Frucher was forced to appeal to member factions for their support. He won some concessions, made others, boosted market share, and finally won approval for a reorganization that made possible the Nasdaq deal and the inclusion of former member-owners in the proceeds.
In his talk, Frucher linked the exchange to its former neighbor, that museum of democracy, Indepdence Hall. The Declaration of Independence made personal freedom a national goal, the Constitution "brought that definition to more and more people," while "widening access to power, economic opportunity, and upward social mobility" -- which is "exactly what capital markets do."
Nasdaq will keep the PHLX open as an options-trading center. "As long as they're profitable, they'll be here," said Giordano. "The business will make that decision. It won't be emotional."
Nasdaq's Chris Concannon sounded humble on that point: "When you look at all the history - we're just simple stewards."
Joseph N. DiStefano
It's not hard to get a roomful of
The "Region on the Rise" conference, sponsored by the Chamber of Commerce and the General Building Contractors Association met Tuesday on the unfinished 25th floor of Liberty Property Trust's new Comcast tower.
Deputy mayor and ex-New York developer and -D.C. city official Andrew Altman, after touring the Comcast building, called it "an incredible slice of the 21st Century economy," with floors-full of "programmers in jeans" alternating with "venture capitalist folks in casual business attire" and button-down "corporate" officers. He said the
Joseph N. DiStefano
Ben Franklin Technology Partners, the taxpayer-backed Pennsylvania start-up financier, spreads $2.3 million to sell wrinkle cream, water heating, online ads and other small business plans:
Bret J. Dunlap's Advanced Mobile Solutions Worldwide Inc., Wayne, which sells mobile-phone ad software to newspapers, $250,000.
Shimin Luo's American Hometec Inc., which designs tankless water heating systems, $100,000. Luo has promised to move the company to Pennsylvania.
ColdLight Solutions LLC, Fort Washington, which offers data-oriented market research, $250,000.
Kevin Casey's Collages.net Inc., Langhorne, a Web site developer, $150,000., bringing total Ben and related support to $500,000.
Keith A. Greathouse (ex-Dermik Labs)'s DermAdvance Pharmaceuticals Inc., Berwyn, anti-wrinkle cream, $500,000.
Chris Conway's Healthy Humans LLC, Wayne, which is setting up a Web site for sick people "to live healthy and well," $150,000.
Dan Roitman's Internet Order LLC, Philadelphia, which direct-markets Pimsleur language courses, $200,000.
Paul Mellon Jr.'s Novetas (formerly New Age Blast Media, part of stud-welder New Age Fastening Systems Inc.), which recyles glass for use in sand-blasting, is moving to Pennsylvania to collect $300,000.
Susan Ng's and Peter Ringer's Real-Time Tomography, LLC, Villanova, breast cancer imaging, $150,000.
Chris Stanchak's TicketLeap LLC, online event ticket sales, $250,000.
Other deals today:
Rohm & Haas adds a Vietnam plant to its global operations. Inquirer story here.
Virtua starts work on its $32 million Washington Township (Gloucester) facility. Inquirer story here.


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Dreading That College Reunion
Think you're the only one nervous about that upcoming class reunion? Nope. Ellen Gordon Reeves reveals the dirty little secret in an article for Harvard Magazine:
everyone is nervous. Everyone I talked to-whether in their twenties or their eighties-doctors, lawyers, heads of hedge funds, best-selling authors, deans, diplomats, tenured professors, top executives alike-confessed to me the same fears about coming back. We worry about what to wear and what we look like, about expanding waistlines and receding hairlines. We worry about running into old flames, old friends with whom we've lost touch, old enemies. We fear being the one who doesn't know where to stand, who has no one to sit with, the wandering minstrel hovering alone at the periphery of a tent. We worry that no one will understand what we're going through or what we've been through. We all worry.
Ever been to a class reunion? Nervous? Was everyone else, too?
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An innovative conveyor lane divider from Nolu Plastics (Aston, PA) enables conveyor systems to be reconfigured with quick, simple adjustments. Aluminum rails fitted with Nolu D guides attach onto a conveyor system to create two or more distinct lanes, dividing the conveyor surface while guiding product.
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100 Happy Things
Comment(s): 26
On December 1, 2010, I posted the start of my list titled 100 Happy Things.
The purpose of this list is to have something to look at to remind me of the things that always, always, always make me smile and feel good.
It's a work in progress…
- A good run
- An awesome spinning class
- Britney Spears' "Oops (I Did It Again)" music video
- Red Starburst
- Getting all the dishes done and having an empty sink
- Making lists
- Finding out at the register that something is on sale
- Magazine day in the mail
- Finding money
- Fall foliage
- Apple picking at Gould Hill Orchard in New Hampshire
- Freshly baked chocolate chip cookies
- Will Ferrell
- Watching old dance videos from competitions and recitals
- Playing with a puppy
- The High Line Park in NYC
- Outlet shopping with Mom
- Beech Hill Farm in Hopkinton, NH
- Seeing really tall people
- Seeing really big dogs
- Seeing cruise ships on my morning run
- Having sore arms
- Running in Central Park
- When the laundry is all done and put away
- Finishing writing an article
- Driving with the windows down
- When no one sits in front of you at the movies so you can put your feet up
- The first time you use a new soap or lotion scent
- Ice cream sandwiches
- Mom's fleetchki (noodles, cheese, yum)
- Honey's meatballs (Honey is my grandmother and her Swedish meatballs are to die for—everyone fights over them at Christmas)
- Ocean City, NJ
- Peeling a Clementine in one peel
- Getting real mail from someone
- Peeing in the ocean (yeah, maybe I'm gross—but you know you do it, too)
- The smell of a campfire
- Taking off your bra at the end of the day
- Elmo from Sesame Street
- Getting the answers right on Jeopardy! (Even if it is "Little Kids Week")
- Andes mints
- When delivery food arrives really fast
- Having a funny dream and waking up laughing
- Eating raw cookie dough
- Seeing your food come out of the kitchen at a restaurant
- Going on the playground swings
- Double Stuffed Oreos dipped in milk
- Picking a wedgie (oh so satisfying)
- Getting a massage
- Having the warm pizza box on your lap in the car
- Getting a piece of cheese at the deli
- Really hot winter showers
- Outdoor showers
- Macintosh scented Yankee Candles
- Getting out an ingrown hair (whatever, I never claimed to be perfect…or sexy)
- High fives
- Putting your own shoes back on after you go bowling
- When the teacher calls you out for doing a move correctly during a group fitness class
- Blog comments
- Getting a raise
- Slipping into my white spa robe after a gloriously long, hot shower
- The smell of new tennis balls
- The smell of American Girl books
- Hotel lobby bathrooms
- When you flip a pancake perfectly
- Eating s'mores
- Getting out of the car after a really long trip
- When the person puts the medal around your neck after finishing a great race
- When your last mile is your fastest mile
- David Beckham
- David Beckham shirtless
- Giraffes!!!
- When you finish folding your laundry and all the socks match up. No sock orphans!
- Everything about the New York City Marathon
- Playing SPIT by the fire with my mom at Christmas time
- The sound when you empty the trash on your computer
- Tyler
26 Responses to "100 Happy Things"
Pingback: Happy Hanukkah! | Ali on the Run
I thought #25 said, "having some arms," lol – sore is more like it.
This is a really cute idea. Fantastic ones, I was nodding the whole time:)
Finding money in your pocket.
the smell of new dance shoes…it was always my fav…of course becuase old dance shoes don't smell to hot..lol
I love the idea of this! I'd add a hot bowl of oatmeal to my list =]
Love it!! I laughed so hard when I got to 50!
Jess : )
It made me happy to read this!! I just found your blog and am loving it!
Putting on your own shoes after taking off ski boots. That was the best feeling ever.
Tara Marie says: February 7, 2011 at 12:10 am
Just found your blog- I want to add curling up under a blanket in front of a fire with an AWESOME book!! That is one of my favorite things to do!!!
What a great idea! I love your list and I just stumbled across your blog and think it's great!
"Seeing really tall people" – So true! I never really thought about this but YES! I would like to add "Girl Scout Cookie season" to the list.
Hearing your favorite song on the radio!
Love this list! Made me smile when I read tons of them cause they would be on my list too. Just came across your blog, looking forward to reading more
Ali says: July 15, 2011 at 9:29 pm
Taking off my bra at the end of the day is my absolute favorite… I've never heard anyone else say it! Thank you!!
I love this! By the way, I just discovered your blog and I'm in love so glad I stumbled upon it!!
100 Happy Things
66. Hotel lobby bathrooms (The Marriott Marquis in Times Square…beautiful!!)
Listening to my husband trash-talk to other people through his Xbox. Weird…but ultimately makes me smile.
Nickey says: October 9, 2011 at 10:36 pm
40. Taking off your bra at the end of the day…I love this one, I never feel like my day is done until I do. This is a really great list. I would also add the last glass of wine at an outdoor cafe before it gets too cold.
Michelle Dodds says: October 10, 2011 at 6:42 am
This list makes me smile especially 22. I am a 6'2 half Filipino newbie runner. I love discovering and reading new blogs bc I am too shy to ask questions half the time. Thank you for your inspiring and funny site!
Michelle D. says: October 10, 2011 at 11:05 am
Totally true lol almost forgot that one…
This is such an awesome idea. I love it!
stealing this idea and a few of yours. love it! Thanks for sharing.
pink starburst. Pink, I say!!!
Emmy says: November 14, 2011 at 3:55 pm
Changing leaves, scoops of peanut butter, the smell of snow, babies laughing, the feel of new sneakers
Belting out a song regardless of who is around, a song you may not know the lyrics to but try to sing anyways just because it's stuck in your head. <- I do that just because it's fun and puts a smile on my face. p.s. I'm a horrible singer and usually do NOT know the lyrics.
Tasting all the flavors at self serve frozen yogurt shops just because you can and perhaps trying them for a second time just to be sure. <- I do that too!


text:
New Hibernia Review
Volume 18. Number 1, Spring/Earrach 2014
pp. 50-57 | 10.1353/nhr.2014.0009
This is the most perfect fusion, surely,
of man and machine; Pat McGlinchey in March 52.
The tape yields, welcoming into its cellulose
the scratched reel of an émigré in Williamsburg
and delivering it to my ear-buds safely
through what analogue and cloned generations?
Fiddle insistency. The creak of horsehair makes a frayed sublime.
Spools whirr in an out-of-hours immigrant bar.
For each jig twists to meet itself
like a corkscrew shaped hill
and every slow air is the sea
The man whose tune becomes a standard
takes leave of it, in awed disappointment
must watch it depart, like a teary child tracing
a kite that's been wind-caught, pilfered,
that's just a cerise and hand-made diamond vanishing,
trailing its brilliance above the winter roofs,
cherished, remarked on, by craned ignorant necks
that know nothing of its birth or begetter.
For each jig twists to meet itself
like a corkscrew shaped hill
and every slow air is the sea
Look at him sidelong at 60, in his crisp maroon uniform,
as he discreetly opens the rear doors of sedans
on a Manhattan dawn of awnings, of gratuities
so delicately palmed (Good Morning Mrs Wilkinson,
Afternoon Mr Stein, Good Evening Mr Finch),
he who'd spun reels to a peasant, insurmountable race,
whose hornpipes had charmed the very spindrift,
had made it hover above the shingle at Killary.
For each jig twists to meet itself
like a corkscrew shaped hill
and every slow air is the sea
You may christen a raucous and runaway thing,
dub it 'The Frisco', 'Indreabhán' or 'Comferford's Ditch'
but raw tunes care no more for such appellations
than islands for the names mariners give,
for 'Fola', or 'Christmas' or 'Van Diemen's Land'.
Aloof creatures, they are; self-delighted, more heedless of title
than the comet's world-perturbing fist of ice and ammonia
or the far and lightless estates of the moon.
For each jig twists to meet itself
like a corkscrew shaped hill
and every slow air is the sea
His huge fingers rollick. They frisk. The machine listens
it renders its own hissed accompaniment (Good Morning Patrick,
Why Thank You Paddy, Good Evening Pat). Digital amber:
to my iPod and latte across six decades of resignation
and static comes, this rough trinket plucked from forgetting.
As a child loves the flyaway kite. As the body loves the soul
in the seconds after dying. The tape's salving magnetism.
The reels go round and round. You have named nothing.
Memory House
I outsourced all my memories to machines.
Addresses, specifics, had long been the stuff of paper and pen.
Numbers went then: the digits of colleagues and loves to a
long division then arithmetic to the buttons of a calculator.
All was subtraction. I delegated sat-navs to remember my way for
handsets to carry birthdays and tasks, deadlines, anniversaries.
Next trivia. Dates and places evaporated, became droplets in the
as I downloaded app after app for remembering, for forgetting.
I left the matching of names and faces to the iKnow (Make
awkward moments
at parties a thing of the past) swapped pins for a fingerprint,
transplanted recollection wholesale to a battery of servers,
every disc abrim with biographies, humming with summers and Christmases.
To liberate capacity, of course. Brain space. Cortical RAM.
But mainly just to do without what memories bring:
the mockery, their guilt, the crowded dreams. And now it's
And now, thank Christ, I can remember nothing except for this;
this stay against night, this precaution for sleeplessness I
couldn't let go of:
Aisling, I'm beside you in the high-ceilinged music room.
I feel welcome here in your mother's house, I feel a welcome
as I watch your apt hands. Disdainful, aloof to themselves, to the keys,
they send a mist of arpeggios through the cool and shaft-lit
to the lowest terrace of the garden, to the heat-lapped lawn
where Saoirse pivots and glides, rehearsing at the steps to the
The apple trees acclaim her drowsy solo; speckle her with confetti.
Her blond form is flexed in...
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Thu., January 5, 2012 10:05am
Cumberland Island Fire Persists
A 55-acre fire is burning at the center of Cumberland Island National Seashore. Officials say the fire originated south of Willow Pond trail between Tuesday night and Wednesday morning. As of Thursday, 30 percent of the blaze was contained.
Full Story
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text:
Sephora Pro Round Powder Brush #60
2 reviews
0% would repurchase
Package Quality: 3.0
Price: $$$
Package Quality: 3.0
Price: $$$
Age: 30-35
Skin: Combination, Medium Brown, Not Sure
Hair: Brown, Other, Other
Eyes: Brown
UGH! So disappointed. This brush sheds like crazy!!! I am so upset! It cost almost $50 bucks and it sheds all over your face! Don't buy!
Age: 25-29
Skin: Combination, Tan, Warm
Hair: Brunette, Other, Other
Eyes: Brown
This is the worst brush that I've tried from Sephora's new line of brushes. It sheds like crazy. It is the most expensive brush in the line at just under $50. The few reviews that are on the Sephora website confirm that the brushes shed, so obviously there was some kind of defect when making these brushes. Do yourself a favor and do not waste your money on this brush.
Popular Makeup Brushes
515 Reviews
20 Reviews
241 Reviews
952 Reviews
133 Reviews
1484 Reviews


text:
Q: "I was diagnosed with lung cancer six months ago and underwent surgery as part of my treatment. Since then I find myself getting short of breath very easily. Will this go away with time?"
American Cancer Society's home page with links to all types of cancer, symptoms, treatment options, statistics trials and ways to contribute.
BACKGROUND: Although mortality rates for some cardiovascular procedures seem to have declined, it is unclear whether other high-risk procedures are becoming safer over time. STUDY DESIGN: We examined national trends between 1994 and 1999 in operative mortality for 14 high-risk cardiovascular and cancer procedures in the national population of Medicare beneficiaries over age 65. Secular trends were examined using logistic regression adjusting for age, gender, race, socioeconomic status, admission acuity, comorbidities, and hospital volume. RESULTS: Observed mortality rates varied widely across the 14 procedures, from 2% (carotid endarterectomy) to 16% (esophagectomy).
BACKGROUND: This survey was performed to determine the patterns of surgical care provided patients with non-small cell lung carcinoma (NSCLC). METHODS: In 2001, the American College of Surgeons carried out a patient care survey of 729 hospitals to retrieve information of NSCLC patients' history, evaluation, pathology, and surgical treatment.
OBJECTIVE: We sought to examine the effect of subspecialty training on operative mortality following lung resection. SUMMARY BACKGROUND DATA: While several different surgical subspecialists perform lung resection for cancer, many believe that this procedure is best performed by board-certified thoracic surgeons.


text: The Death of a Living Legend((so I only wrote Steve's P.O.V's kay? The rest are from the users in the bottom (with slight altercations), you'll see 'em. These were all based off a RP journal that there's a link to down below~))~~~Steve's P.O.V.Steves feet were dragging- no this wouldn't happen. No. His arms were sore from all the hits he had to take and all the hits he had to give, all the blows thrown out of nowhere yet hitting everywhere. These enemies fought dirty, like cowards. Though Steve would never stoop to there level even if it meant-- too late. A blow to the head, "A-Ah.." a punctured organ- ouch that looked important, "GAH!" Now, a few broken ribs, two, three-- five! "Nn... ah...hah..." his breathing was weakening, he held his shield close as he looked around. Out numbered. He was the only one there for the mean time, everyone else was on there way, Tony half way across the world, Bruce somewhere in hiding, Thor in Asgard, Natasha in Estonia, Clint at the S.H.I.E.L.D head quarters


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Reader's Reviews (4)
Works on Gret Danes!
posted 6 years ago
By brother in law has 2 Danes. One is 12 yrs. old and was really uncomfortable because of his knee and hip pain. This actually worked. The dog was moving around much better after 3 days.
Pros: It works!
Cons: none
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posted 6 years ago
At the shelter we hadused many diff kind sof supplements for dog who were arthritic ly have lyme ect, this product as well as some others seem to work, but since the animal was under alot of stress at the shelter it was hard to tlel
Pros: Seems to work
Cons: Not sure if it really does
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Tapeworm Tablets
June 8, 2015 | By Lynn
I've used this product on rescued dogs for years. My last large dog rescued had been an outdoor dog her entire life, living among Lamas where she picked up tapeworms. This product expelled several 2 … more ›
November 15, 2014 | By Robyn
July 14, 2013 | By Xiaoxiao111
Pink is my favorite color these are wonderful.I will recommend a good website fou you: www.9footballshirt.org


text:
I was recently in the Frankfurt airport and noticed that the escalators have motion sensors, i.e., they run only when necessary. Eureka! Lights in stairwells and bathrooms in many other countries are set on timers. Apparently, keeping your car serviced and your tires properly inflated can save 3 to 6 percent on gas mileage. And driving at or under the speed limit while refraining from aggressive acceleration and braking saves even more.
Conservatives are right to stress the virtues of non-carbon-emitting nuclear power, and liberals have strenuously opposed it for reasons that are 90 percent emotional and 10 percent rational. But why should we scorn solar? It cannot replace oil and gas, that's clear. But particularly for the South and Southwest regions of the U.S. that are drenched in sunshine most of the year, solar makes excellent sense as a supplement to fossil fuels. Why not at least use it to heat water as many other countries do?
All of these energy-saving measures make sense even if you are unconvinced (as I am) that the world trembles on the brink of a human-caused climate catastrophe. Just to deprive OPEC of a few of our dollars would justify any number of conservation efforts -- to say nothing of drilling in the 1 percent of the Arctic National Wildlife Refuge that contains oil (perhaps, say some estimates, more than Prudhoe Bay). Those pictures we've all seen of moose and caribou against a backdrop of verdant mountains are a fraud. The coastal plain, where drilling is proposed, is flat, barren, and characterized by unforgiving permafrost.
Finally, Al Gore and Barbra Streisand could give up their private airplanes and fly first class, but one doesn't wish to overreach.
Rush Limbaugh defends Rubio's debate answer: He's absolutely right that Obama knows what he's doing | Allahpundit
Time for Team Hillary to break out the gender card for young liberal women who prefer Sanders | Allahpundit


text:
The British Columbia Liberal government is not acting in the best interests of the rare Spirit Bear being imprisoned at a zoo in Kamloops. The Premier and Environment Minister have not responded to offers by ecology organizations to provide a rehabilitation study to ensure a safe hibernation and release in 2013.
This bear, named "Clover", had no human conflicts from July to October. The brief feeding of this bear and others did not stop the bears from coming and going in mid October. They were not dependant on humans. There were fish nearby and it was unfortunate circumstances that led to this issue. Clover appears to have been singled out for capture. This was the first human contact for Clover and there should not have been only "the shoot or zoo" limited options.
Lifeforce, a Vancouver based ecology/animal rights organization, had advised the Premier that we could work together to conduct a study that would leave options open for Clover's release. Bears are innately wild and would revert back to their natural wild instincts. The bear would be released in an isolated area of the Great Bear Rain Forest.
The Kamloops zoo manager said that this is like "winning a lottery". However, the bear would lose his freedom. Sounds as if money is the real reason why the bear is being imprisoned. Spirit Bears must not become a new zoo fad. A new bear jail could exceed $500,000 in addition to any grants for experiments under the guise of conservation.
Monies are better spent on true conservation programs that include preserving natural ecosystems. Most people want to see Super Natural BC not Super Unnatural BC Zoos.
This bear should not be faced with a life time zoo sentence when it was the fault of stupid humans who were trying to feed "Clover" and other bears. Clover is not guilty of any human harassment. He is innocent and should be given a chance at freedom.
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Safer Internet Day (SID) is organised by Insafe in February of each year to promote safer and more responsible use of online technology and mobile phones, especially among children and young people across the world.
Safer Internet Day 2016 will be celebrated on Tuesday 9 February 2016, with a theme of 'Play your part for a better internet!'.
This website will showcase the many events and activities taking place across the globe to mark the day.


text:
Arenal Backpackers ResortLa Fortuna, Costa Rica
Great hostel but the staff is far too laid back and in cahoots with tourism companies. If you have them book a shuttle DEMAND Greyline (free wifi on) or Interbus. DO NOT let them tell you it's all the same and that shuttles run all day or they will call their friend's crappy service Arenal ABP Tours (which they get a kickback on) and you'll end up on the most uncomfortable ride ever. Be sure to clarify who you want to book through before asking the front desk to book anything on your behalf.
Arenal Backpackers ResortLa Fortuna, Costa Rica
Hot showers, air conditioning, giant pool, bar with a happy hour, delicious food, computer room, and staff that helps you book tours. This is a no brainer - this is where you should stay!
Blue Trailz Hostel & Surf CampTamarindo, Costa Rica
Great location! Across the street from the beach where street vendors sell $1 coconuts and homemade ice cream. Staff is very friendly and helpful. There's an Interbus and tourism office around the corner if you need help booking shuttles or tours as Blue Trailz focuses mostly on surf lessons. The place is cleaned daily but the bathroom always seems to be covered on beach sand and smells of poop. $6 laundry service at 10am everyday and lots of restaurants, supermarkets
Hostel Villa Vento SurfPanama City, Panama
I really like it here. Air conditioning, lots if bathrooms, a pool, helpful staff and $1 beers. It's also a 40 minute walk from Old Town and there are lots of places to eat, gamble and drink within walking distance. If you're looking to go to David, ask a taxi to take you to Albrook Terminal - it will cost maybe $5 but confirm your rate before you get in.
Jungla de PanamaBoquete, Panama
Though Jungla De Panama is just outside of Boquete, I adored waking up to monkeys, donkeys, boas, goats
Hostel Villa Vento SurfPanama City, Panama
I really liked it here. Friendly staff, $1 beers in their fridge, 40 min walk to Old Town and close to restaurants, casinos and a bank. Plenty of showers and they even have a pool.


text:
A press release from Congressman Peter Roskam: President Obama Signs Roskam, Carney Medicare Fraud Provisions Into Law WASHINGTON, DC—Today, Congressman Peter Roskam (R-IL) and Congressman John Carney (D-DE) released the following statements after President Obama signed into law H.R. 2, … Continue reading
Category Archives: Medicaid Fraud
From Congressman Randy Hultgren: Hultgren Takes on Medicare and Medicaid Waste, Fraud and Abuse This year marks the 50th anniversary of the Medicare and Medicaid social safety net programs. More than 50 million disabled Americans and seniors rely on Medicare … Continue reading
A press release from Congressman Randy Hultgren: Combating Waste, Fraud, and Abuse in Medicare and Medicaid with the PRIME Act Washington, DC – In an effort to combat waste, fraud, and abuse in the Medicare and Medicaid programs, U.S. Representative … Continue reading
A press release from the U.S. Attorney's Office: ILLINOIS HOSPICE EXECUTIVE CHARGED WITH FEDERAL HEALTH CARE FRAUD FOR ALLEGEDLY FALSELY ELEVATING LEVEL OF PATIENTS' CARE CHICAGO — An owner of an Illinois hospice company was charged with federal health care … Continue reading
A press release from State Senator Pam Althoff: Senate Week in Review: April 1 – 5, 2013 SPRINGFIELD, IL – Despite the state's ongoing credit woes, improved market conditions allowed Illinois to achieve a near record-low interest rate on construction … Continue reading
A press release from the U.S. Attorney's Office: CHICAGO PSYCHIATRIST ALLEGEDLY SUBMITTED AT LEAST 190,000 FALSE CLAIMS TO MEDICARE AND MEDICAID; LAWSUIT ALLEGES KICKBACKS TO PRESCRIBE ANTIPSYCHOTIC MEDICATION FOR NURSING HOME PATIENTS CHICAGO — A Chicago psychiatrist received illegal kickbacks … Continue reading
A press release from the U.S. Attorney's Office: NINE DEFENDANTS, INCLUDING TWO OWNERS OF A HOME HEALTH CARE AGENCY AND TWO PHYSICIANS, INDICTED FOR ALLEGEDLY PAYING AND RECEIVING KICKBACKS FOR MEDICARE PATIENT REFERRALS CHICAGO — Two owners of a home … Continue reading
Monday another mailing from "Independent" Dee Beaubien arrived in 52nd State Rep. District mailboxes. It was again financed by House Speaker Mike Madigan's Illinois Democratic Party. This oversized post card takes on Medicaid fraud, which has been at the 10% … Continue reading
When I opened my mailbox Saturday, what did appear but another big postcard from the man who wants to be my future Congressman, Peter Roskam. You can see it below: … Continue reading
The Skinners get back from vacation and what appeared in the mailbox? Along with the other accumulated mail were two postcards from Congressman Peter Roskam, the incumbent in the current 6th Congressional District who seeks to represent the newly-Madiganized 6th … Continue reading


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I need EITHER a Flex Application or a PHP script that interacts with PHPBB3 forums.
1) Gets URL and account info from my db. (if it's Flex then using AJAX, or if it's php then use MySQL).
2) Logs in to the PHPBB3 forum mentioned.
3) Looks at memberlist to find admin.
4) Sends PM to admin.
5) Record whether successful or not to my db. (If it's Flex then using AJAX, if it's php then use MySQL.)
then repeats over and over.
If you are able to do multithreading (that works) this is a plus -- please mention.
If you are able to make a tool for both PHPBB2 and PHPBB3 then please mention in your bid - otherwise will be assumed is just for PHPBB3.
If you have any similar experience please show/explain examples.
PLEASE ANSWER: 1) If bid is for multithreaded or not. 2) If bid is for just PHPBB3 or both PHPBB2 and PHPBB3. 3) If you have any relevant examples/experience of similar projects.
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Are you Hidemasa Tamai?Claim your profile
Publications (14)24.84 Total impact
Article: Effect of Hospital Volume on Long-term Outcomes of Laparoscopic Gastrectomy for Clinical Stage I Gastric Cancer[Show abstract] [Hide abstract]
ABSTRACT: This study aimed to examine the effect of hospital volume on long-term outcomes of patients who underwent laparoscopic gastrectomy for clinical stage I gastric cancer. A total of 420 patients with clinical stage I gastric cancer who underwent laparoscopic gastrectomy at our university hospital (high-volume group) and affiliated hospitals (low-volume group) were included in this study. Overall survival (OS) and cause-specific survival (CSS) rates were analyzed. No significant differences were observed in the number of lymph nodes retrieved (29.9 vs. 27.7, p=0.21) and CSS between the high- and low-volume groups (p=0.92), although the OS rate in the low-volume group was significantly less than that in the high-volume group (p=0.045). These results indicate no clinical impact of hospital volume on prognosis of patients who underwent laparoscopic gastrectomy for clinical stage I gastric cancer when performed by surgeons with sufficient experience in open gastrectomy.
Article: Tumor-Induced CD11b+Gr-1+ Myeloid Cells Suppress T Cell Sensitization in Tumor-Draining Lymph Nodes[Show abstract] [Hide abstract]
ABSTRACT: Suppression of tumor-specific T cell sensitization is a predominant mechanism of tumor escape. To identify tumor-induced suppressor cells, we transferred spleen cells from mice bearing progressive MCA205 sarcoma into sublethally irradiated mice. These mice were then inoculated subdermally with tumor cells to stimulate T cell response in the tumor-draining lymph-node (TDLN). Tumor progression induced splenomegaly with a dramatic increase (22.1%) in CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSC) compared with 2.6% of that in normal mice. Analyses of therapeutic effects by the adoptive immunotherapy revealed that the transfer of spleen cells from tumor-bearing mice severely inhibited the generation of tumor-immune T cells in the TDLN. We further identified MDSC to be the dominant suppressor cells. However, cells of identical phenotype from normal spleens lacked the suppressive effects. The suppression was independent of CD4(+)CD25(+) regulatory T cells. Intracellular IFN-gamma staining revealed that the transfer of MDSC resulted in a decrease in numbers of tumor-specific CD4(+) and CD8(+) T cells. Transfer of MDSC from MCA207 tumor-bearing mice also suppressed the MCA205 immune response indicating a lack of immunologic specificity. Further analyses demonstrated that MDSC inhibited T cell activation that was triggered either by anti-CD3 mAb or by tumor cells. However, MDSC did not suppress the function of immune T cells in vivo at the effector phase. Our data provide the first evidence that the systemic transfer of MDSC inhibited and interfered with the sensitization of tumor-specific T cell responses in the TDLN.
Article: Immunotherapy of Established Murine Squamous Cell Carcinoma Using Fused Dendritic-Tumor Cell Hybrids[Show abstract] [Hide abstract]
ABSTRACT: To investigate the therapeutic efficacy of fused dendritic-tumor cell hybrids against murine squamous cell carcinoma (SCC). Squamous cell carcinoma VII is a poorly immunogenic murine SCC tumor in C3H/HEN (H-2(K)) mice. Subdermal tumors were established by inoculation in the mid abdomen of mice. Tumor diameters were measured with a Vernier caliper and used as an indication of treatment efficacy. Survival studies were performed on mice with 3-day pulmonary metastasis or subdermal tumors. Dendritic cells were generated from bone marrow and cultured for 8 days. Dendritic cells were harvested and mixed with cultured tumor cells in a 1:1 ratio. Cell fusion was achieved by exposing the cell mixture to an alternate electrical current to bring cells into alignment and close together, followed by a short direct electrical current pulse. Female C3H/HEN mice aged 8 to 12 weeks. Mice with 3-day established SCCVII tumors were vaccinated by inguinal intranodal injection of fusion cells (0.3 x 10(6) per side). To support the development of antitumor immunity, mice were given adjuvant injections intraperitoneally. Anti-OX40R monoclonal antibodies or interleukin 12 were used. Treatment groups included no treatment, anti-OX40R monoclonal antibodies or adjuvant IL-12 alone, fusion cells alone, and fusion cells with adjuvant treatment. Tumor size and overall survival. Mice treated with adjuvant treatment or fusion cells alone did not show a statistical difference in tumor growth when compared with controls. In contrast, fusion cells with adjuvant treatment demonstrated a significant decrease in tumor size when compared with nontreated mice (P < .001). Treatment with fusion cells also resulted in increased survival in the pulmonary metastasis and subdermal tumor models. Immunotherapy with fused dendritic-tumor cell hybrids can significantly affect 3-day established sSCC VII tumor growth.
Article: Effective treatment of spontaneous metastases derived from a poorly immunogenic murine mammary carcinoma by combined dendritic–tumor hybrid vaccination and adoptive transfer of sensitized T cells[Show abstract] [Hide abstract]
ABSTRACT: Curative immunotherapy against spontaneous metastases of poorly immunogenic tumors has been difficult to demonstrate, but it is highly relevant to clinical disease conditions. The 4T1 mammary carcinoma shares many characteristics of human mammary cancer. Here, mice with 4T1 spontaneous metastases were treated effectively with a combination of dendritic (DC)-tumor hybrid vaccination and adoptive transfer of tumor-draining lymph node-derived immune T cells. This strategy significantly prolonged survival and cured some mice. In this model, the combined immunotherapy induced a dramatic increase of T cells in the lung where metastases were located and in the spleen where tumor was not present. The mechanism of increasing numbers of T cells is likely attributed to the ability of DC-tumor hybrids to stimulate vigorous proliferation of adoptively transferred T cells rather than to promote their infiltration into tumor-harboring and lymphoid organs. Taken together, the combined approach may be useful for clinical development of cancer immunotherapy.
- [Show abstract] [Hide abstract]
ABSTRACT: Laryngeal transplantation has not been widely accepted because of concerns regarding accelerated tumor recurrences in the setting of nonspecific immunosuppression. Allotransplantation could potentially be offered to patients if immunosuppressive therapy could be demonstrated to exert tumor suppressive properties. Preliminary reports have demonstrated an antiproliferative effect of everolimus (RAD), a derivative of the immunosuppressant rapamycin. Forty-five 10-week-old inbred C57BL/6N (B6) mice were injected subcutaneously with 1 x 10(6) MCA205 sarcoma cells. On the third postinoculation day, the mice were divided into 4 treatment groups, undergoing daily gavage with RAD at 0, 0.2, 1.0, and 5.0 mg/kg per day for 10 consecutive days. Thereafter, treatment with RAD was discontinued and tumor size was measured every 2 days during treatment and biweekly until sacrifice on the 31st postinoculation day. Whole-blood trough levels (C(min)) were measured for each group. Mean tumor diameter among the control animals and the mice treated with RAD 0.2 mg/kg per day demonstrated no significant difference (P > .07). Groups treated with RAD 1 and 5 mg/kg per day demonstrated significant growth inhibition between the 7th and the 23rd postinoculation days (P < .0001), with no significant differences being noted between these two groups (P > .09). Mean tumor suppressive whole-blood C(min)'s for the 1 and 5 mg/kg per day groups were 75.6 and 368.9 pg/microL, respectively. RAD delivered at immunosuppressive doses of 1 and 5 mg/kg per day resulted in significant growth restriction of a fibrosarcoma in a murine model.
Article: Induction of Peptide-Specific Immune Response in Patients with Primary Malignant Melanoma of the Esophagus after Immunotherapy Using Dendritic Cells Pulsed with MAGE Peptides[Show abstract] [Hide abstract]
ABSTRACT: Primary malignant melanoma of the esophagus (PMME) is a very rare disease with an extremely poor prognosis. Surgery is currently considered its best treatment, while any other measures are ineffective. We studied the effect of active specific immunotherapy using monocyte-derived dendritic cells (DCs) pulsed with the epitope peptides of melanoma-associated antigens (MAGE-1, MAGE-3) in patients with PMME after surgery, for the first time. The patient received passive immunotherapy with lymphokine-activated killer cells concomitantly. Two HLA-A24-positive patients with PMME were treated. Both patients initially received radical esophagectomy with regional lymphadenectomy, followed by adjuvant chemotherapy with dacarbazine, nimustine, vincristine and interferon-alpha. In the case 1 patient, active specific immunotherapy was used to treat a large abdominal lymph node metastasis that became obvious 21 months after surgery. The disease remained stable for 5 months, and the patient survived for 12 months after the initiation of immunotherapy. In the case 2 patient, immunotherapy was tried as post-operative adjuvant treatment after adjuvant chemotherapy. There was no tumor recurrence for 16 months after the immunotherapy. As of 49 months after esophagectomy, the patient is still alive. In both patients, the ability of peripheral lymphocytes to produce IFN-gamma in vitro in response to peptide stimulation was significantly enhanced and delayed-type hypersensitivity skin test response to MAGE-3 peptide was turned positive after immunotherapy. In conclusion, active specific immunotherapy for PMME with the use of DCs and MAGE peptides was safe and capable of inducing peptide-specific immune responses. This case report warrants further clinical evaluation of this immunotherapy for PMME.
Article: Induction of cytotoxic T lymphocytes against human cancer cell lines using dendritic cell-tumor cell hybrids generated by a newly developed electrofusion technique[Show abstract] [Hide abstract]
ABSTRACT: Recently, dendritic cells (DCs) and DC-tumor cell hybrids (DC-tumor hybrids) have been used for cancer vaccine therapy in a clinical trial. DC-tumor hybrids combine the potent antigen-presenting capacity of DCs with the ability to present all tumor antigens expressed on tumor cells to T cells. We used DC-tumor hybrids as stimulator cells to induce tumor-specific cytotoxic T lymphocytes (CTLs) in vitro. DC-tumor hybrids were generated from human monocyte-derived DCs and human cancer-cell lines (GT3TKB, lung cancer; GCIY, gastric cancer) by our newly developed electrofusion technique, established and refined with the use of mouse cells. To evaluate the capacity of DC-tumor hybrids generated by our method to induce tumor antigen-specific CTLs, we performed a cytotoxic assay and an interferon-gamma release assay using CD8-dominant effector lymphocytes induced by them. DC-tumor hybrids more effectively induced tumor-specific primary T-cell response than did stimulation with DCs co-cultured with irradiated tumor cells overnight, irradiated tumor cells alone, or a mixture of DCs and irradiated tumor cells. DC-tumor hybrids were generated at a high fusion rate by our electrofusion technique. When CTLs were induced by DC-tumor hybrids in vitro, the high fusion rate did not contribute to the induction of CTLs with increased tumor-specific cytotoxicity. The addition of interleukin-12 to the culture medium did not augment the cytotoxicity of CTLs. Overall, our results suggest that DC-tumor hybrids effectively induce human tumor-specific CTLs and may thus be applicable for clinical trials of adoptive immunotherapy.
Article: Mechanism of third signals provided by IL-12 and OX-40R ligation in eliciting therapeutic immunity following dendritic-tumor fusion vaccination[Show abstract] [Hide abstract]
ABSTRACT: Dendritic-tumor heterokaryons generated by electrofusion are highly immunogenic. In animal studies, a single vaccination was therapeutic for tumors established in the lung, skin, and brain. However, effective therapy required a third signal which could be provided by exogenous IL-12 or the agonistic anti-OX-40R monoclonal antibody (mAb). In this study, we investigated the mechanism and mode of actions of these two seemingly distinct adjuvants. In immunotherapy of the MCA205 sarcoma, administration of the neutralizing anti-IL-12 mAb nearly completely blocked the adjuvant effect of IL-12, but had minimal inhibitory effects on anti-OX-40R mAb. By contrast, in vivo administration of the antagonistic anti-OX-40L mAb inhibited the adjuvant effects of both IL-12 and anti-OX-40R mAb. Thus, a common pathway of endogenous OX-40 interaction is critical for the development of a therapeutic immune response. Analysis of the third signal mechanism revealed that in the absence of an adjuvant, vaccination with fusion hybrids led to IL-10 production without eliciting IFN-gamma secreting cells. The addition of IL-12 to vaccination suppressed IL-10 production and initiated sensitization of specific IFN-gamma secreting cells, resulting in a type 1-like antitumor immunity. These findings underscore the significance of the third signal in the design of dendritic cell-based cancer vaccines.
Article: Mature dendritic cells generated from patient-derived peripheral blood monocytes in one-step culture using streptococcal preparation OK-432 exert an enhanced antigen-presenting capacity[Show abstract] [Hide abstract]
ABSTRACT: Dendritic cells (DCs) have been shown to be potent in inducing cytotoxic T cell (CTL) response leading to the efficient anti-tumor effect in active immunotherapy. Myeloid DCs are conventionally generated from human peripheral blood monocytes in the presence of interleukin (IL)-4 and granulocyte/macrophage colony-stimulating factor (GM-CSF). Streptococcal preparation OK-432, which is known to be a multiple cytokine inducer, has been extensively studied as to its maturation effects on immature DCs using an in vitro culture system. The purpose of this study was to examine whether it could be possible to generate mature DCs directly from peripheral monocytes using OK-432. We specifically focused on the possibility that recombinant cytokines, which are considered to be essential for in vitro DC generation, could be substituted by OK-432. Human peripheral monocytes, which were obtained from patients with advanced cancer, were cultured with IL-4 and OK-432 for 7 days. Cultured cells were compared with DCs generated in the presence of IL-4 and GM-CSF with or without OK-432 with regard to the surface phenotype as well as the antigen-presenting capacity. As a result, the culture of monocytes in the presence of IL-4 followed by the addition of OK-432 on day 4 (IL-4/OK-DC) induced cells with a fully mature DC phenotype. Functional assays also demonstrated that IL-4/OK-DCs had a strong antigen-presenting capacity determined by their enhanced antigen-specific CTL response and exerted a Th1-type T cell response which is critical for the induction of anti-tumor response. In conclusion, human peripheral blood monocytes cultured in the presence of IL-4 and OK-432 without exogenous GM-CSF demonstrated a fully mature DC phenotype and strong antigen-presenting capacity. This one-step culture protocol allows us to generate fully mature DCs directly from monocytes in 7 days and thus, this protocol can be applicable for DC-based anti-tumor immunotherapy.
Article: [The effects of direct hemoperfusion using the filtration column filled with the adsorption fiber for immunosuppressive substances on cell-mediated immunity in tumor-bearing rats].[Show abstract] [Hide abstract]
ABSTRACT: The patients with advanced cancer often lose their anti-tumor immune responses due to the increase of some immunosuppressive substances in the blood, such as cytokines and proteins derived from cancer cells or immune cells. We developed the adsorption fiber in transforming growth factor (TGF)-beta for the treatment to remove immunosuppressive substances and investigated the effects of direct hemoperfusion using the filtration column filled with this adsorption fiber in tumor-bearing rats. On day 0, KDH-8 tumor cells (1 x 10(6) cells/rat) were implanted subcutaneously into the back of WKAH/Hkm rats. On day 21 after tumor implantation, the rats underwent the direct hemoperfusion with this filtration column for 60 minutes. On day 28, the rats were sacrificed and the natural killer (NK) activities of their spleen cells were examined. As a result, the rats that underwent this treatment showed a significant increase in their NK activities compared with those of rats who underwent direct hemoperfusion with an empty column or had no treatment. Therefore, we indicated the possibility of a new immunotherapy technique against cancer using a direct hemoperfusion column filled with an adsorption fiber for immunosuppressive substances.
Article: [Immunotherapeutic reactivity of dendritic cells loaded with a variety of antigen preparations].[Show abstract] [Hide abstract]
ABSTRACT: The findings summarized here provide a direct comparison of the immunogenicity of various DC loading strategies included pulsing with protein, peptide, tumor cell lysate, irradiated tumor cells and electrofusion of DCs and tumor cells. For the treatment of 3-day established pulmonary metastases, electrofusion of DCs and tumor cells generated a therapeutic vaccine far superior to other methods of DC loading. Consistent with their therapeutic activity, fusion hybrids stimulated the release of the largest amount of interferon-gamma from immune T cells. However, IL-10 secretion did not correlate with in vivo therapeutic reactivity. In conclusion, DC-tumor fusion hybrids were the most effective vaccine to eradicate existing tumors. These data support the use of DC-tumor electrofusion cells for the treatment of human cancer.
Article: [Two case reports of complete regression of liver metastases from colorectal cancer after locoregional immunochemotherapy].[Show abstract] [Hide abstract]
ABSTRACT: Hepatic arterial infusion (HAI) with pharmacokinetic modulating chemotherapy (PMC) has been well known to be one of the most effective protocols for unresectable liver metastases from colorectal cancer. PMC is a combination of oral UFT and continuous hepatic arterial 5-FU infusion. We present herein the cases of two patients with multiple liver metastases from colorectal cancer in whom complete regression (CR) was achieved by HAI with PMC in combination with Lentinan (immunostimulator). These patients received HAI via an implantable port system with a 4-24-hour continuous perfusion of 5-FU at 1,000 mg/m2 plus Lentinan at 2 mg/body once a week, and oral administration of UFT at 200-300 mg/m2/day everyday. CR of all metastatic lesions in the liver was achieved 4 months after the initiation of the treatment in both patients. One patient maintained CR for 3 months, but he died due to a recurrence of liver metastases and peritoneal dissemination 19 months after the initiation of the treatment. The other patient has been well without recurrence for 21 months. Because the liver is the largest immunologic organ, Lentinan could have activated lymphocytes and macrophages in the liver. Judging from the clinical experience of these two cases, HAI with PMC in combination with Lentinan could be one of the most promising treatment strategies for unresectable liver metastases from colorectal cancer.
Article: A case of intractable pancreatic fistula following pancreaticoduodenectomy successfully cured by interventional internal drainage.
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ABSTRACT: The liver is an uncommon primary site for malignant lymphoma, and primary hepatic lymphoma has been found to make up 0.4% of all extranodal lymphomas. We report a rare case of a 75-year-old Japanese male with primary hepatic Burkitt's lymphoma, according to both the revised European-American Lymphoma classification and the new World Health Organization classification. As not only histological findings but also immunological features are deemed essential in the diagnosis of Burkitt's lymphoma, the previous 7 cases of primary hepatic Burkitt's lymphoma were not fully evaluated, using these criteria. As far as we know, this is the first case of primary hepatic Burkitt's lymphoma with typical features on histological, immunological and cytogenetical analysis. He had a history of chronic hepatitis C over several decades with subsequent liver cirrhosis. From our review of the literature and our case, the relationship between hepatitis C virus infection and the development of primary hepatic Burkitt's lymphoma remains obscure.
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Kyoto Prefectural University of Medicine
Kioto, Kyoto, Japan
- • Graduate School of Medical Science
- • Division of Digestive Surgery
Cleveland ClinicCleveland, Ohio, United States


text:
Genre: Comedy
Premise: This largely improvised comedy chronicles the dysfunctional mayhem at radio station KBOM, where inept intern Lance takes over hosting a morning radio show after the previous host defects to satellite radio. To say Lance's debut is a disaster would be a wild understatement, but he's so bad, in fact, that the show's ratings actually go up -- which provides only minor comfort to Anna, his co-host, and James, the station manager, who nicknames Lance's show ``Moron in the Morning.''
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