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Articles Archive for Year 2009
About Belize, Belize Travel Tips »
About Belize, Belize Testimonials »
This is the name pilot-photographer Marius Jovaisa chose for his book of photographs about Belize. Last Wednesday, December 9, he released the first copy, presenting it to Tourism Minister Manuel Heredia, at a ceremony at the Radisson Fort George Hotel
Belize Testimonials, Vacation Sweepstakes »
Welcome to a world so steeped in history that one needs only to open one's eyes if you are looking to be fascinated. A family vacation in Belize is worth a hundred social studies classes for children. And a great way for mom and dad to experience first hand, what they were once taught from books.
Hiking through temples or snorkeling the reefs, there is more to discover than you could ever imagine. There is archaeological mystery hidden above and below the earth that are waiting to be discovered by you and your family. Gold, ruins, architecture, and natural wonders are all a part of Belize.
About Belize, Belize Travel Tips »
Belize is divided into four main geographic regions, including the relatively low Maya Mountains of the south that dominate all but the narrow coastal plain; the northern lowlands and its many rivers and streams; the flat and swampy coastal plain, and the almost countless cayes, islands and lagoons that fringe its Caribbean coastline.
About Belize, Belize Testimonials »
Cayo is the largest district in Belize and is a world leader in ecotourism. If you are vacationing in the pristine Cayo District; you must definitely visit the following Maya Temples and Ceremonial Caves:
Xunantunich or Maiden of the Rock is situated on the Western Highway across the river from the village of San Jose Succotz. This major ceremonial center can be reached by ferry daily and it is only 1.5 Kilometer (one mile) from some lovely rapids of the …
About Belize, Belize Testimonials »
Belize is the Best! I've been to my share of Caribbean destinations: the Windward Islands of St. Lucia, St. Vincent and Grenada; the Leeward Islands of Anguilla, St. Barth's, St. Martin & Antigua; as well as the Cayman Islands. I'd have to say Belize is my favorite Caribbean destination, edging out my former favorite, Grenada. Both Grenada and Belize have some of the same high scores on my Caribbeo Meter: lots of varied terrain, nice beaches, interesting culture, friendly people and lack of high-rise hotels and mass tourism. Both countries let you experience everything from the beach to rainforests to traditional cutlures.
About Belize, Belize Testimonials »
Why Belize you ask? Here are the criteria we used that helped us arrive at Belize:
* Had to be less than 8 hours of flight time each way from the SF Bay Area
* Wanted excellent beach with reasonably priced accommodations
* Great nature experience
* A little bit of history and adventure mixed in (Mayan ruins)
Headline, Vacation Sweepstakes »
These fun-filled holidays of a life-time are being provided to friends & families who would like to enjoy a truly special Belize adventure free of charge. Chaa Creek, a pioneer in adventure travel since its inception in 1981 provides culture based environmental programs that introduce friends & families to the tropical rainforests of western Belize.
Belize Testimonials »
Once upon a time quite long ago, the majestic and powerful Harpy Eagle was the alpha predator in many parts of Central America. Through habitat loss, the Harpy was on the verge of extinction, but through a programme by the Peregrine Fund with partnership of the Belize Zoo, the largest Eagle of the Americas is making a comeback. And they are doing particularly well in Belize.
While the first one, named Panama, came to the Belize Zoo in 2003 the idea …
Headline »
The Lodge at Chaa Creek, Belize's award-winning family vacation destination in the jungles of Central America, is offering free all inclusive holidays to the lucky winners of our Family Vacation Sweepstakes.
These fun-filled holidays of a life-time are being provided to families who would like to enjoy a truly special Belize adventure free of charge. Chaa Creek has been family friendly since its inception in 1981 providing culture based environmental programs that introduce families to the tropical rainforests of western Belize.
Belize Travel Tips, Headline »
Belize, located in Central America, shares borders with Mexico to the north and Guatemala to the west, stretching in length along the Caribbean Sea to its east. Composed of many cultures speaking a variety of languages, Belize, once under British rule, is oddly the only country in Central America where English is the official language. Although it's a small country, roughly the size of Massachusetts, getting from place to place can take the better part of a day. So with an eight-day trip, we narrowed down our visits to two different regions, one in the western part of Belize and one in the southeast.
Belize Testimonials, Belize Travel Tips »
A multitude of fun filled activities are guaranteed to keep up the adventure tempo, and include canoeing on Jungle Rivers, horseback riding through forested trails, hiking and biking in the foothills of the Maya Mountains, bird watching by day, safari trekking at night, and pampering at the hilltop full-service rainforest spa.
Belize Hotels »
My family has chosen Chaa Creek as the best family vacation for us because of the beauty and luxury it is known for. We have been looking to vacation someplace where we can find adventure as well as relaxation, and we know Chaa Creek would be the ideal destination for our next family trip. We feel sure it can help us enjoy the best family vacation possible. We love adventure sports and learning and we know we can be provided …
Belize Testimonials »
Belize Testimonials »
About Belize, Belize Testimonials »
Belize Hotels »
I would like our first ever vacation as a family to be to Chaa Creek in Belize. My husband and I honeymooned there two years ago and vowed to come back as a family. We had such an amazing, eye-opening, life-changing experience, that we cannot wait to share it with those we love most. This year, two has become three and the love of our life, our wide-eyed 4-month-old boy, is a sponge. We want him to absorb all the beauty that Chaa Creek has to offer.
Belize Testimonials »
About Belize, Belize Testimonials »
Part of the natural beauty of Belize is its lush and green rainforest which is abundant in flora and fauna. But there is more to just the verdant rainforest, Belize also offers an uncommon but sacred trip into the past, with a scope into the new world. There is a secret little place, nestled in the heart of Belize's unspoiled rainforest. From the moment you step foot on it, it magically but also naturally transfers your mind into the secrets of the past – the Lodge at Chaa Creek.
About Belize, Belize Testimonials »
For generations, descendants of the ancient civilizations have tried to guard the country's natural and historical riches. More recently, the Belize government realized that discovery by tourists – though it is most welcome and a shot in the arm for the economy – places the country's treasures in peril. At risk of being "loved to death" are the barrier reef, the hemisphere's most extensive cave system, the Maya ruins and the sensitive rainforests that shelter endangered jaguars and hold the cures to many of the world's ills.


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Darren Stone Photographer
Muirina FaeModel Female Victoria, British Columbia, Canada
Mayhem # 2601871
About Me***Rarely log on to MM anymore, if you'd like to work together rather email me at email@example.com or at least include your email in your message on here, else I might not manage to get back to you on time - sorry!
The difference between an image and art is meaning. Lets create art together.
I've been modeling since 2007, but both my parents are photographers, so even before 2007, I had an extensive amount of time in front of a camera.
I am able to do my own hair, makeup, wardrobe, and even retouching, if required. I am always in amazing shape because I am a dancer, and dancing gives me an extra bonus of making me a great poser. Not only do I understand my body very well, I understand direction very well too. You do not need to spend much time explaining to me what exactly you want. You say it, and I'll do it almost immediately, so you can keep on shooting.
I already have a full portfolio under a different alias (Please contact me for my full portfolio). Paid shoots take precedence.
Recently came back from an international contract to Japan, and planning on many more traveling projects in the coming months, keep checking back if I'm on my way to a place near you! :)
Have you worked with Muirina Fae? Add Credits for Muirina Fae! >>
Darren Stone Photographer
Sand and Lace Photographer
Alan Worsfold Photo Photographer
Tristan JD Model
saviorprod... Photographer
x-posure images Photographer
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"Gotham's" Azrael Will Be 'Different Than Anything We've Seen in Comics,' Says EP
All-Day Event!
The film based on Andy Diggle and Jock's "The Losers" opens today in theatres nationwide.
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Marzocchi B.C. office takes over Canadian distribution
NORTH VANCOUVER, British Columbia (BRAIN) — Marzocchi Canada is now the official distribution center for all of Tenneco Marzocchi products throughout Canada. For the past nine years Marzocchi Canada has provided dealer and customer service, sales and tech support. Moving forward Marzocchi ...
Posted September 25, 2014 in North America
Fox Factory buys 'certain assets' of Marzocchi's mountain bike product lines
to Marzocchi's mountain bike suspension product line. The company did not say what assets it will buy, but indicated that it will market the Marzocchi brand worldwide and use the brand to hit new price points. ...
Posted October 19, 2015 in International
Fox completes purchase of Marzocchi assets
products across more price points. When coupled with our existing legacy bike business, the Marzocchi ...
Posted November 13, 2015 in North America
Fox still evaluating what to do with Marzocchi
parts business. Fox is not planning to buy Marzocchi's power sport-related assets, and Fox executives ...
Posted November 4, 2015 in North America
Marzocchi on the block; MTB production continues — for now
I sincerely hope for Marzocchi, our customers, our supplier and the mountain bike team that a sale ...
Posted July 31, 2015 in International
Marzocchi's parent, Tenneco, to shut down suspension business
employs 127 people at the Marzocchi plant in Bologna, Italy, and an additional 11 people in its operations ...
Posted July 22, 2015 in North America
Marzocchi signs Cyclone for distribution
for quick retail fulfillment," said Mat Brown, North American sales for Marzocchi USA. "Marzocchi is a great brand with a long and storied history in mountain bike suspension," said Cyclone ...
Posted February 12, 2015 in North America
Marzocchi 350 CR designed for aggressive terrain, enduro racing
can contact Marzocchi North America directly at (800) 227-5579. ...
Posted June 25, 2014 in New Products
Marzocchi offers trail builders a discount
LONG BEACH, Calif. (BRAIN) — To reward "the unsung, forgotten heroes" of mountain biking, Marzocchi is offering U.S. trail builders special pricing on a fork and shock. "Marzocchi wants to reward you for all the work you put in over the fall, winter and spring to bring us the amazing ...
Posted July 15, 2014 in North America
Marzocchi looks to Hodaka for assembly
negotiations for SR Suntour to buy the brand ended. The disruption caused Marzocchi to lose much of its 2013 ...
Posted July 12, 2012 in International


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We are wholesalers of Color Enhanced Diamonds ( [obscured] ) I am looking for someone to create an app that would feature our jewelry and loose diamond pictures. I only want it to be a showcase for our products. It should be something the retailers can show his customers and than order from us and something that consumers can go learn about our products and than go to a jewelry store near them and see up close.
I think we should have about 100 pictures of loose diamonds and about 200-250 pictures of jewelry. There will be some changing of backgrounds required on the pictures but not a lot of touching up as the pictures are good quality. I can upload some examples before awarding contract to u.
There should be 3 parts -
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Are you Janos Aradi?Claim your profile
Publications (41)151.23 Total impact
Article: Myelotoxicity of carboplatin is increased in vivo in db/db mice, the animal model of obesity-associated diabetes mellitus[Show abstract] [Hide abstract]
ABSTRACT: Some authors observed increased carboplatin-associated myelotoxicity in obese patients which was exclusively attributed to elevated AUC. To investigate the potential contribution of functional changes of cells primarily responsible for myelopoiesis, granulocyte-macrophage progenitors (CFU-GM) were studied in obesity-associated diabetes mellitus (DMT2). The most frequently used animal model of human obesity with DMT2 is db/db mouse. Cellularity, frequency of CFU-GM and total CFU-GM content of femoral bone marrow were measured after 100 mg/kg dose of carboplatin in vivo. To exclude influence of pharmacokinetic changes, direct toxicity of carboplatin on CFU-GM was also determined in vitro and was compared with other anticancer agents, namely doxorubicin, 5-fluorouracil and 4-thiouridylate. After intraperitoneal administration of carboplatin, each measured characteristics of bone marrow function was more significantly suppressed and the induced neutropenia was more serious in db/db mice than in the controls. The increased myelotoxicity seemed to be a direct effect on myeloid progenitor cells since their increased in vitro sensitivity was found in db/db mice. This was not specific for carboplatin, a similar double to fivefold increase in myelotoxicity of each cytotoxic drug with different mechanism of action was observed. Four-thiouridylate, a promising antileukemic molecule with good therapeutic index, was by far the least toxic for CFU-GM of db/db mice. A serious disorder of CFU-GM progenitors was suggested in obese mice with DMT2, which eventually might lead to more severe myelotoxicity and neutropenia. Weight loss and normalization of glucose homeostasis may be important before chemotherapy of malignant diseases in obesity with DMT2.
Article: Thiolated pyrimidine nucleotides may interfere thiol groups concentrated at lipid rafts of HIV-1 infected cells[Show abstract] [Hide abstract]
ABSTRACT: Upon HIV infection, cells become activated and cell surface thiols are present in increased number. Earlier we demonstrated in vitro anti-HIV effect of thiolated pyrimidine nucleotide UD29, which interferes thiol function. To further analyse the redox processes required for HIV-1 entry and infection, toxicity assays were performed using HIV-1 infected monolayer HeLaCD4-LTR/ β-gal cells and suspension H9 T cells treated with several thiolated nucleotide derivatives of UD29. Selective cytotoxicity of thiolated pyrimidines on HIV-1 infected cells were observed. Results indicate that thiolated pyrimidine derivates may interfere with -SH (thiol) groups concentrated in lipid rafts of cell membrane and interacts HIV-1 infected (activated) cells resulting in a selective cytotoxicity of HIV-1 infected cells, and reducing HIV-1 entry.
Article: P3.190 Epidemiology of HIV Infection Before and After Rising the Iron Curtain: The Hungarian Experience
Article: A challenging epigenetic message: telomerase activity is associated with complex changes in lifestyle[Show abstract] [Hide abstract]
ABSTRACT: As an outcome of The 2009 Nobel Prize in Physiology or Medicine, a connection has been highlighted between the length of telomeres and epigenetic effects, such as intensive changes in lifestyle and nutrition as well as behavioural and psychological factors. In this review, the various elements of molecular, cell biological, nutritional and lifestyle changes are introduced and discussed.
Article: In vitro and in vivo activity of 4-thio-uridylate against JY cells, a model for human acute lymphoid leukemia[Show abstract] [Hide abstract]
ABSTRACT: We have previously reported the in vitro anti-proliferative effect of 4-thio-uridylate (s(4)UMP) on OCM-1 uveal melanoma cells. Here, we assessed the efficacy of s(4)UMP on JY cells. Treatment of JY cells with s(4)UMP suppressed their colony forming activity and induced apoptosis; healthy human bone marrow granulocyte-macrophage progenitor cells were 14-fold less sensitive to the nucleotide. In vivo effectiveness of s(4)UMP was determined using xenograft SCID mouse model. s(4)UMP decreased the cell number and colony forming activity of the total cell content of the femur of SCID mice transplanted with JY cells without affecting the bone marrow of healthy mice. These results suggest that s(4)UMP alone or in combination with other clinically approved anti-leukemic remedies should be further explored as a potential novel therapeutic agent.
Article: [The 2009 Nobel Prize in Medicine and its surprising message: lifestyle is associated with telomerase activity].[Show abstract] [Hide abstract]
ABSTRACT: The 2009 Nobel Prize in Physiology and Medicine was awarded to three scientists for their pioneer research on telomeres - and the enzyme that forms them - telomerase. Their work highlighted the considerable connection between the length of telomeres and intensive changes in lifestyle and nutrition (Ornish method) as well as behavioral and psychological factors. In this review the various elements of molecular, cell biological, nutritional and lifestyle changes are introduced and discussed.
Article: Epigenetic plasticity of hTERT gene promoter determines retinoid capacity to repress telomerase in maturation-resistant acute promyelocytic leukemia cells[Show abstract] [Hide abstract]
ABSTRACT: The expression of hTERT gene, encoding the catalytic subunit of telomerase, is a feature of most cancer cells. Changes in the chromatin environment of its promoter and binding of transcriptional factors have been reported in differentiating cells when its transcription is repressed. However, it is not clear whether these changes are directly involved in this repression or only linked to differentiation. In a maturation-resistant acute promyelocytic leukemia (APL) cell line (NB4-LR1), we have previously identified a new pathway of retinoid-induced hTERT repression independent of differentiation. Using a variant of this cell line (NB4-LR1(SFD)), which resists to this repression, we show that although distinct patterns of histone modifications and transcription factor binding at the proximal domain of hTERT gene promoter could concur to modulate its expression, this region is not sufficient to the on/off switch of hTERT by retinoids. DNA methylation analysis of the hTERT promoter led to the identification of two distinct functional domains, a proximal one, fully unmethylated in both cell lines, and a distal one, significantly methylated in NB4-LR1(SFD) cells, whose methylation was further re-enforced by retinoid treatment. Interestingly, we showed that the binding to this distal domain of a known hTERT repressor, WT1, was defective only in NB4-LR1(SFD) cells. We propose that epigenetic modifications targeting this distal region could modulate the binding of hTERT repressors and account either for hTERT reactivation and resistance to retinoid-induced hTERT downregulation.
Article: 4-Thio-uridylate (UD29) interferes with the function of protein –SH and inhibits HIV replication in vitro[Show abstract] [Hide abstract]
ABSTRACT: In this short communication, it is shown that 4-thio-uridylate (s(4)UMP, designated as UD29) inhibits glyceraldehyde 3-phosphate dehydrogenase (GAPDH), suggesting that the enol-form of the thiolated nucleotide may interfere with the function of the essential -SH group in the active center of the enzyme. Since HIV entry requires thiol/disulfide exchange processes, this activity prompted us to study the anti-HIV activity of the nucleotide. Indeed, UD29 inhibited the replication of HIV-1(IIIB) in the MT-4 cell line and HIV-1(Ada-M) in peripheral blood mononuclear cells (PBMC). Furthermore, UD29 was not toxic in PBMCs in vitro or in mice when the compound was administered intravenously.
Article: 4-Thio-deoxyuridylate-modified thrombin aptamer and its inhibitory effect on fibrin clot formation, platelet aggregation and thrombus growth on subendothelial matrix[Show abstract] [Hide abstract]
ABSTRACT: The consensus thrombin aptamer C15-mer is a single-stranded DNA of 15 nucleotides [d(GGTTGGTGTGGTTGG)] that was identified by the selection of thrombin-binding molecules from a large combinatorial library of oligonucleotides. It is capable of inhibiting thrombin at nanomolar concentrations through binding to a specific region within thrombin exosite 1. As has been shown in our earlier studies, the 4-thio-deoxyuridylate (s4dU)-containing oligonucleotides have high affinity for a number of proteins, due to the reduced hydrophilic character of the modified oligonucleotide. Three different analogs of the original thrombin-inhibiting sequence, in which some of the thymidylate residues were replaced by 4-thio-deoxyuridylates, were synthesized. The inhibitory effect of modified aptamers was tested on thrombin-catalyzed fibrin clot formation and fibrinopeptide A release from fibrinogen, thrombin-induced platelet aggregation/secretion, and the formation of thrombus on coverslips coated with human collagen type III, thrombin-treated fibrinogen or subendothelial matrix of human microvascular endothelial cells. As compared with the C15-mer, the analog with the sequence GG(s4dU)TGG(s4dU)G(s4dU)GGT(s4dU)GG (UC15-mer) showed a 2-fold increased inhibition of thrombin-catalyzed fibrin clot formation, fibrinopeptide A release, platelet aggregation and secretion in human plasma and thrombus formation on thrombin-treated fibrinogen surfaces under flow conditions. Concerning the inhibition of thrombin-induced fibrin formation from purified fibrinogen and activation of washed platelets, UC15-mer was 3-fold and twelve-fold more effective than C15-mer, respectively. The replacement of four thymidylate residues in C15-mer by 4-thio-deoxyuridylate resulted in a new thrombin aptamer with increased anticoagulant and antithrombotic properties.
Article: Bcl-2 Antisense Oligonucleotide Inhibits the Proliferation of Childhood Leukemia/lymphoma Cells of the B-cell Lineage[Show abstract] [Hide abstract]
ABSTRACT: An 18-mer phosphorothioate bcl-2 antisense oligonucleotide (ASO) inhibited colony formation of three B-cell leukemia/lymphoma cell lines in a dose dependent manner in the range of 0.125-0.5 micromol/l. The scrambled cogener had no detectable effect. A decrease in BCL-2 protein and apoptotic DNA fragmentation was detected in the studied cell lines and primary blast cells of two children with acute lymphoblastic leukemia. Neither BCL-2 protein level, nor DNA integrity was affected by the scrambled control indicating the specific effect ASO. As far as we know, this is the first report on the effects of bcl-2 ASO on childhood leukemia/lymphoma cell samples.
Article: Pharmacological intervention strategies for affecting telomerase activity: Future prospects to treat cancer and degenerative disease[Show abstract] [Hide abstract]
ABSTRACT: Telomerase enzyme is a ribonucleoprotein maintaining the length of the telomeres by adding G-rich repeats to the end of the eukaryotic chromosomes. Normal human somatic cells, cultured in vitro, have a strictly limited proliferative potential undergoing senescence after about 50-70 population doublings. In contrast, most of the tumor cells have unlimited replicative potential. Although the mechanisms of immortalization are not understood completely at a genetic level, the key role of the telomere/telomerase system in the process is clear. The DNA replication machinery is not able to replicate fully the DNA at the very end of the chromosomes; therefore, about 50-200 nucleotides are lost during each of the replication cycles resulting in a gradual decrease of telomere length. Critically short telomere induces senescence, subsequent crisis and cell death. In tumor cells, however, the telomerase enzyme prevents the formation of critically short telomeres, adding GGTTAG repeats to the 3' end of the chromosomes immortalizing the cells. Immortality is one of the hallmarks of cancer. Besides the catalytic activity dependent telomere maintenance, catalytic activity-independent effects of telomerase may also be involved in the regulation of cell cycle. The telomere/telomerase system offers two possibilities to intervene the proliferative activity of the cell: (1) inhibition the telomere maintenance by inhibiting the telomerase activity; (2) activating the residual telomerase enzyme or inducing telomerase expression. Whilst the former approach could abolish the limitless replicative potential of malignant cells, the activation of telomerase might be utilized for treating degenerative diseases. Here, we review the current status of telomerase therapeutics, summarizing the activities of those pharmacological agents which either inhibit or activate the enzyme. We also discuss the future opportunities and challenges of research on pharmacological intervention of telomerase activity.
Article: Supramolecular polymers based on quadruplex formation of ditopic guanosine macromonomers in non-aqueous media
Article: Supramolecular Polymers Based on the Quadruplex Formation of Ditopic Guanosine Macromonomers in Nonaqueous Media[Show abstract] [Hide abstract]
ABSTRACT: The formation of supramolecular polymeric aggregates with a molecular mass of 100 kDa in a nonaqueous solution from a telechelic dimer of isopropylidene guanosine in the presence of K+ ions is reported. The possible structure of macromonomers resulting from the development of G(4) quartets was deduced from DOSY NMR, circular dichroism spectra, and dynamic light scattering measurements. The formation of supramolecular polymeric aggregates with a molecular mass of 100 kDa in a nonaqueous solution from a telechelic dimer of isopropylidene guanosine in the presence of K+ ions is reported. The possible structure of macromonomers resulting from the development of G(4) quartets was deduced from DOSY NMR, circular dichroism spectra, and dynamic light scattering measurements.
Article: Effect of the extent of thiolation and introduction of phosphorothioate internucleotide linkages on the anti-HIV activity of Suligovir [(s(4)dU)(35)][Show abstract] [Hide abstract]
ABSTRACT: Suligovir is a 35-mer homo-oligonucleotide, containing exclusively 4-thio deoxyuridylate, proved to be a potent inhibitor of HIV entry. In this paper, we described the effect of extent of thiolation and the introduction of nuclease-resistant phosphorothioate linkages on the anti-HIV activity of Suligovir. We found that the decreased thiolated nucleotide content decreases the anti-HIV potency of the compound and the introduction of phosphorothioate linkages does not improve its antiviral activity.
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ABSTRACT: Brachytherapy is a well-established, effective treatment for uveal melanoma with a failure rate of 15%. The fatal consequence of unsuccessful treatments offers reason for improvement of the method. The authors propose using an apoptosis inducing agent locally, concomitantly with the well-established therapy, to sensitize the tumor cells. The authors propose a new nontoxic moderately active apoptosis inducing agent, 4-thio-uridylate (s4UMP), for this purpose. OCM-1 uveal melanoma cells were treated with various concentrations of s4UMP and its effect was monitored by measuring the cell viability (MTT assay). The following apoptosis detecting methods were performed to reveal the mechanism of decreased cell viability: light microscopy, DNA fragmentation assay, determination of caspase 9 activity, and FACS analysis. The viability of uveal melanoma cells was decreased by 32%, 40%, and 9% after 24, 48, and 72 hours of treatment with 10 microg/mL (30 microM) s4UMP. The effect was not dose dependent; it rather followed a saturation-type inhibition and the cells at lower drug concentration recovered after 72 hours. Characteristic apoptotic cell morphology and DNA fragmentation was detected in treated cells. The caspase-9 was activated upon treatment showing maximal activity at 48 hours suggesting the induction of apoptosis. The annexin binding activity further verified the apoptogenic activity of s4UMP. Uveal melanoma, more than other solid tumors, is resistant to most of the chemotherapeutic protocols as indicated by the high mortality rate of metastatic disease. The authors showed that s4UMP, a naturally occurring nucleotide, could induce apoptosis in uveal melanoma cells, suggesting a potential supplementary therapeutic application of the compound.
Article: Wu YL, Dudognon C, Nguyen E, Hillion J, Pendino F, Tarkanyi I et al.. Immunodetection of human telomerase reverse-transcriptase (hTERT) re-appraised: nucleolin and telomerase cross paths. J Cell Sci 119: 2797-2806[Show abstract] [Hide abstract]
ABSTRACT: The involvement of telomerase in cellular immortalization and senescence has often been assessed by means of telomerase expression at the RNA level and quantification of telomerase activity by the telomeric repeat amplification protocol assay. However, these methods either neglected the existence of various telomerase splice variants, or ignored the nonconventional functions of telomerase independent of its ability to elongate and maintain telomere length. Immunodetection of telomerase is now being recognized as a necessary approach to precisely elucidate its roles in oncogenesis and senescence. A few antibodies directed against the catalytic subunit of the human telomerase (hTERT) are currently used but their specificity is not always demonstrated. A survey of the literature showed inconsistencies and led us to comparatively re-evaluate the most frequently used antibodies. Surprisingly, mass spectrometry, two-dimensional gel analysis and immunofluorescent experiments revealed that the most frequently used hTERT immunoprobe, a mouse monoclonal antibody that was claimed to be directed against an hTERT protein epitope, in fact recognizes nucleolin rather than telomerase. Our findings have interesting implications regarding the biology of nucleolin and telomerase in the context of pathophysiological investigations recently carried out.
Article: Apoptotic response of uveal melanoma cells upon treatment with chelidonine, sanguinarine and chelerythrine[Show abstract] [Hide abstract]
ABSTRACT: The benzophenanthridine alkaloids sanguinarine, chelerythrine and chelidonine were reported previously to provoke cell death in a variety of tumor cells suggesting their potential application as anticancer agents. Here we tested their effects on a primary human uveal melanoma cell line, OCM-1. Flow cytometric analysis of annexin V binding/PI exclusion and DNA fragmentation disclosed that all these alkaloids could induce apoptosis in OCM-1 cells. Moreover, necrotic cell death was also observed upon alkaloid treatment. As it was also evidenced by light microscopic inspection of cellular morphology, chelidonine primarily caused apoptosis, while sanguinarine and chelerythrine were effective via a so-termed bimodal cell death (apoptosis and primary necrosis). The relative efficiencies of the two modes depended on the applied dose. This study is the first implication for the possible use of these alkaloids in the therapy of uveal melanomas, for which no really efficient therapeutic regimen is available so far.
Article: Deoxy-adenosine-monophosphate (dAMP) di-n-butylester induces apoptosis by increasing the dATP level in HL-60 cells[Show abstract] [Hide abstract]
ABSTRACT: Deoxy-ATP is a potent inducer of apoptosis. We intended to synthesize a lipophilic dAMP derivative which, according to our working hypothesis penetrates into the cell, is converted to dAMP by intracellular esterases and to dATP by nucleotide kinases. We synthesized dAMP-di-n-butylester (DAB) and tested it. We found that it fulfills the above-described expectations. DAB treatment decreases the viability of HL-60 cells, increases the dATP concentration and induces apoptogenic cytochrome c release from mitochondria with concomitant elevation of caspase-9 activity. Our results indicate that use of dAMP derivatives with masked phosphate may be a feasible approach for pharmacological elevation of intracellular dATP and induction of apoptosis.
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ABSTRACT: Telomeres are located at the ends of eukaryotic chromosomes. Human telomerase, a cellular reverse transcriptase, is a ribonucleoprotein enzyme that catalyzes the synthesis and extension of telomeric DNA. It is composed of at least, a template RNA component (hTR; human Telomerase RNA) and a catalytic subunit, the telomerase reverse transcriptase (hTERT). The absence of telomerase is associated with telomere shortening and aging of somatic cells, while high telomerase activity is observed in over 85% of human cancer cells, strongly indicating its key role during tumorigenesis. Several details regarding telomere structure and telomerase regulation have already been elucidated, providing new targets for therapeutic exploitation. Further support for anti-telomerase approaches comes from recent studies indicating that telomerase is endowed of additional functions in the control of growth and survival of tumor cells that do not depend only on the ability of this enzyme to maintain telomere length. This observation suggests that inhibiting telomerase or its synthesis may have additional anti-proliferative and apoptosis inducing effect, independently of the reduction of telomere length during cell divisions. This article reviews the basic information about the biology of telomeres and telomerase and attempts to present various approaches that are currently under investigation to inhibit its expression and its activity. We summarize herein distinct anti-telomerase approaches like antisense strategies, reverse transcriptase inhibitors, and G-quadruplex interacting agents, and also review molecules targeting hTERT expression, such as retinoids and evaluate them for their therapeutic potential. "They conceive a certain theory, and everything has to fit into that theory. If one little fact will not fit it, they throw it aside. But it is always the facts that will not fit in that are significant". "Death on the Nile". Agatha Christie.
Article: Retinoid/arsenic combination therapy of promyelocytic leukemia: Induction of telomerase-dependent cell death[Show abstract] [Hide abstract]
ABSTRACT: Acute promyelocytic leukemia (APL) is efficiently treated with a cell differentiation inducer, all-trans retinoic acid (ATRA). However, a significant percentage of patients still develop resistance to this treatment. Recently, arsenic trioxide (As2O3), alone or in combination with ATRA, has been identified as an alternative therapy in patients with both ATRA-sensitive and ATRA-resistant APL. Previous investigations restricted the mechanism of this synergism to the modulation and/or degradation of PML-RARalpha oncoprotein through distinct pathways. In this study, using several ATRA maturation-resistant APL cell lines, we demonstrate in vitro that the success of ATRA/As2O3 treatment in APL pathology can be explained, at least in part, by a synergistic effect of these two drugs in triggering downregulation of telomerase efficient enough to cause telomere shortening and subsequent cell death. Such long-term low-dose combinatorial therapy strategies, developed also to avoid acute side effects, reinforce the notion that the antitelomerase strategy, based on a combination of active agents, should now be considered and evaluated not only in APL but also in other malignancies.
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University of Debrecen
Debreczyn, Hajdú-Bihar, Hungary
- • Department of Biochemistry and Molecular Biology
- • Department of Biochemistry
University at Buffalo, The State University of New York
Buffalo, New York, United States
- Department of Medicine


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Alshan's advantageous geographic position gives the city many fantastic and natural tourist attractions, including the Alshan National Forest Park and the Hot Springs in Alshan. This great natural scenery has helped the city become a newborn tourist attraction in China. Tailor-make your own tour of China to enjoy yourself in nature.
Alshan National Forest Park is located at the southwest foot of Inner Mongolian side of Daxinganlin. It covers an area of 103000 square meters. Alshan National Forest Park is the ideal summer resort due to it..
Alshan is a city of the Chinese province of Inner Mongolia and is located in the far northeastern part of the country near the Russian and Mongolian borders. The name "Alshan" is the Mongolian word fo..
Note: Famous for alpine and cross country trails. Season: Nov. - Apr. Location: On the border of Inner Mongolia (Province) in China and Mongolia itself, 3-4 hours by bus/train from Ulanhot. ..


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With a threaded post and double ring base, this industrial distressed elm bar table is a remarkable find for the breakfast nook or home lounge. The solid elm wood tabletop is beautiful distressed, lending an aged look. The metal base and accents boast an antiqued finish that reinforces the vintage look.
A leader in contemporary design, Zuo Modern Contemporary offers a vast selection of stunning furniture designs. With a focus on evolution, Zuo combines clean lines, top materials, and an extensive color palette to constantly redefine modern furniture. Catering to lovers of contemporary style, Zuo Modern Contemporary, Inc. offers the most current, state-of-the-art furniture designs for your office, home, and outdoor areas.
Our team has over 100 years combined experience with contemporary lighting.
Every EuroStyleLighting.com order is backed by our 100% Satisfaction Pledge.
Shipping and Delivery Information - For item EU2D386 if ordered by 1 pm Pacific Time


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We are planning to have one more and I'm curious what you all think is the best car/suv/van for a family with 3 kids!?
Best car for a family with 3 kids?!
we have 3, and 3 carseats in both vehicles.
i drive a honda odyssey, and hubby has a honda accord. yes, we can get 3 carseats across the back in the accord!
Jennifer�� -��BFFer�wife to John, mommy to Ella Grace, b 8/21/2005, Samson Lee, b 5/7/2008 and Isaac John, b 10/13/2010.!
We have a Ford Freestar w/ the bucket seats in the middle row. Love it! Gets us where we need, reliable, fits 3 car seats along the back bench seat (have had to do that for school field trips), and we can still pack a ton w/ baby gear and lugage for a family of 5 in it.
We didn't see a point in paying $10k or more extra for an SUV that had almost 1/2 the mpg for gas.
If you can afford them, I want a Flex when my freestar dies! W/ the bucket seats for the middle again though.
Proud Army Spouse since 9/23/00 (OCS cadre- Standards, No Compromise!),
Mommy to Nathanael (5/28/02), Philip (9/16/04), and Jadon (10/15/10).
We got a Mazda 5 when planning our third child. It's wonderful because it's cheaper than minivans and other SUVs. The third row can provide seating for 6, but we used it for 5 with one seat up and the other down for the stroller to go in. My husband drives that one now, and I have an Odyssey. I love my Odyssey; it's got plent of room for all of us.
Mom of Jeremy Rush (age 7), Mason James (5), Kate Sinclair (1), Troy Anderson (newborn)
Oh my gosh...you can get 3 car seats in just about any vehicle!! there are slimmer and more compact seats on the market..my dh drives a fuel efficent nissan sentra, and we have 3 car seats in that vehicle, I drive a chevy trailblazer and of course we have enough room....stick within your budget and remember gas prices will probably just keep going up!
Wife to Fred 3.17.07, Mom to Eliana Mieko born 10.25.10, Adeline Sakura born 7.18.13, Eikou Baby in Heaven 1.2014, and sweet Alden Junpei due June 2015!
I am one blessed woman!
Any type of mini van is the most comfortable and practical, IMO.
Conservative momma!
Eden (9/10) Austin (5/08)
We are going to rock out with 3 in our Impala. It will be tight and their friends will have to find their own ride but I don't care. If all goes as planned, that Impala is going to be the car our kids learn how to drive in.
Madalyn 10.06.10 ** Leann 4.03.12 - Born with Tetralogy of Fallot and 22q Deletion Syndrome ** Kaitlyn 11.07.13


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With Instructables you can share what you make with the world, and tap into an ever-growing community of creative experts.
This is my Atari punk organ, it is a 555 timer piano run through an Atari punk console monostable generator, the piano is based on another instructable I ...
This is a video showing what it sounds like:
What youll need to make this: 2x 555 timer chips 2 speakers 10k + 100k potentiometers 20 buttons 20 2k trimmer potentiometers 10n, 100n, 47n and 2 10uf ...
The piano circuit is based of a circuit diagram made by Collin Mitchell, the keyboard is connected through pin 2 and pin 3 goes to both the speaker ...
Making the keyboard needed lots of soldering, the trimmers replace the resistors in the origional diagram and the left and middle pin need to be soldered together, you ...
follow the schematic for the second monostable half of the atari punk console, connecting the ground to the ground on the piano ic and the power to pin 8 through ...
I am using the piano speaker as one of the legs so I used a wine cork that i cut at an angle and superglued that to the ...
51,024 views
153 favorites
Atari Punk Consoleby benekeneb
Atari Punk Consoleby Arush Bansal
APC (Atari Punk Console)by josh1324
How to make the Atari Punk Consoleby TobaTobias
Making Music with an Atari Punk Consoleby JamecoElectronics
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Quick Links
Additional links
District 11
Thursday, May 5, 2011
Contact: Public Information Officer Kara Palmer
Phone: (619) 688-6670
Southbound Interstate 15 Closed Tonight at Poway Road/Rancho Peñasquitos Boulevard
SAN DIEGO – Southbound Interstate 15 (I-15) will be closed tonight with a detour in place at the Poway Road/Rancho Peñasquitos Boulevard bridge, according to the California Department of Transportation (Caltrans). The closure will be in place from 11:30 p.m. to 4:30 a.m.
Motorists traveling south on I-15 will be detoured west on State Route 56 (SR-56) to east on Rancho Peñasquitos Boulevard to southbound I-15. Concurrently, the eastbound and westbound SR-56 connectors to southbound I-15 will be closed. Motorists traveling on SR-56 will be detoured via Rancho Peñasquitos Boulevard onto southbound I-15. Detour signs will be in place to direct motorists.
This closure will allow crews to remove temporary support beams that were needed to rebuild the south side of this bridge as part of the I-15 Express Lanes Project. Bridge work may be noisy but must be done at night to avoid disrupting daytime traffic. For more information on the I-15 Express Lanes project, call the project information hotline at (866) 890-1397 or log-on to www.KeepSanDiegoMoving.com.
# # # #


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MarketWatch reports that Levi Strauss & Co.'s has dropped the Google Checkout option from Levi.com, their main web site. Steve Davis, from the firm that Levi used to integrated Checkout, said they dropped it from Levi.com due to a "particular issue," which was not disclosed (as far as I can tell). What is important to note is that Levi Strauss left Google Checkout on the dockers.com web site, so that issue couldn't of been a huge one or even a global issue (I suspect). I personally have yet to implement Google Checkout on any site, so I cannot speak from experience here. The article does say that Levi.com will most likely add Google Checkout back after Google releases an updated version of feature, probably within a few weeks.
February 9, 2016


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S Patrick Chung preparing to play Sunday
FOXBOROUGH -- Safety Patrick Chung, who missed last week with a thumb injury, said he can play against the Oakland Raiders on Sunday, if Bill Belichick calls his number.
Chung had surgery last week after he injured his thumb against the San Diego Chargers in Week 2 and is now wearing a cast on his right hand. He returned to practice last week and has been limited.
"I feel good," Chung said.
But when it comes to playing Sunday, Chung said all he can do is prepare.
"It's not my decision, I'm just working hard trying to get out there and help the team," he said.
Chung said he could play, if needed.
"... I'll be ready to play," Chung said. "If coach wants me out there, then I'm out there."
The Patriots could use Chung to help a safety group that struggled last week. Here are a few more comments from Chung.
On the number of thumb injuries: "I feel like it just happens. It's a physical game and people are going to come hit you and you're going to try and hit people. You're grabbing constantly, and it happens every once in a while that you might hit your hand on a helmet or someone coming in on a shoulder pad, but it's part of the game."
On preparing for the week: "You have to always [prepare] hurt or injury, you have to prepare mentally and physically to whatever you have to do to make sure that you know what you're doing so if coach needs you to go in there, you're ready."


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Niemann-Pick Type C is a genetic, cholesterol storage disorder that primarily strikes children with death occurring before or during adolescence. There is also an adult onset form of the disease.
The Ara Parseghian Medical Research Foundation is a non-profit organization dedicated to funding medical research projects to find a treatment for Niemann-Pick Type C (NP-C) disease. The Parseghian Foundation is named in honor of Ara Parseghian, the much beloved and well-known Notre Dame Football Coach, whose three youngest grandchildren were diagnosed with NP-C in 1994.
Medical research is the key to saving the lives of all those around the world afflicted with Niemann-Pick disease. You can help by donating to the Ara Parseghian Medical Research Foundation. Thank you.
June 4-7, 2016
Our hearts are broken. The pain of losing our three youngest grandchildren is almost unbearable.
Notre Dame Cycling Team raises moneyfor the Parseghian Foundation
Niemann-Pick Type C (NP-C) disease Research News
One Family's Fighting Spirit - Read The Parseghian Family Story
More About Niemann-Pick - Read an overview of the disease diagnosis, symptoms and treatment.
Research on NPC
-Articles on Potential Therapies
-NIH Clinical Trial Begins for NPC
Contact us about getting involved in the fight against Niemann-Pick disease.
Jim Click Mustang Raffle Winners
Thanks to all of our generous donors for, once again, making us the number 1 Jim Click raffle ticket sellers of 2015.
Congratulations to Colleen Mahoney of Tucson, Arizona for winning the Limited Edition 2015 Ford Mustang.
Congratulations to Parseghian Foundation special raffle winners:
Grand Prize Winner: 4 Box Seat tickets to a Notre Dame football game in 2016
1st through 5th Prize Winners: Coach Ara Parseghian Autographed Football
6th through 10th Prize Winners: Coach Ara Parseghian Autographed Print
September 28, 2015
Vtesse, Inc. Initiates Phase 2b/3 Clinical Trial of VTS-270 for Treatment of Niemann Pick Type C1 (NPC) Disease
Gaithersburg, MD, September 28, 2015 – Vtesse, Inc. today announced that the first three patients have been screened for inclusion in its pivotal Phase 2b/3 clinical trial with VTS-270 for treatment of Niemann-Pick Type C1 Disease (NPC). This clinical trial follows a Phase 1 study conducted by researchers at the National Institutes of Health (NIH) Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
Sadly, the Parseghian family has lost Michael, Marcia and Christa to Niemann-Pick Type C disease. Their hearts will be forever broken.
Their resolve, however, to continue the fight against NP-C disease is not broken. The Parseghians and thousands of volunteers and friends across the US and around the world are raising funds and pushing medical research so that a treatment can be found.
Please help us in this valiant effort so that everyone afflicted with Niemann-Pick around the world can live to realize their hopes and dreams. Thank you.
We Need Your Help!


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A community for students.
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Here's the question you clicked on:
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- 3 years ago
-2 x+4
----- = ------
x+2 x^2-4
- 3 years ago
-2 x+4 ----- = ------ x+2 x^2-4
This Question is Closed
Best ResponseYou've already chosen the best response.1
- 3 years ago
A. x=0, -2 B. x=0,2,-2 C.x=2,-2 D.x=0
Best ResponseYou've already chosen the best response.0
- 3 years ago
A. x=0, -2
Best ResponseYou've already chosen the best response.1
- 3 years ago
Solve for x over the real numbers: -2/(x+2) = (x+4)/(x^2-4) Multiply both sides by a polynomial to clear fractions. Cross multiply: -2 (x^2-4) = (x+2) (x+4) Write the quadratic polynomial on the left hand side in standard form. Expand out terms of the left hand side: 8-2 x^2 = (x+2) (x+4) Write the quadratic polynomial on the right hand side in standard form. Expand out terms of the right hand side: 8-2 x^2 = x^2+6 x+8 Move everything to the left hand side. Subtract x^2+6 x+8 from both sides: -6 x-3 x^2 = 0 Factor the left hand side. Factor x and constant terms from the left hand side: -3 x (x+2) = 0 Divide both sides by a constant to simplify the equation. Divide both sides by -3: x (x+2) = 0 Solve each term in the product separately. Split into two equations: x = 0 or x+2 = 0 Look at the second equation: Solve for x. Subtract 2 from both sides: x = 0 or x = -2 Now test that these solutions are correct by substituting into the original equation. Check the solution x = -2. -2/(x+2) => -2/(2-2) = infinity^~ ~~ infinity^~ (x+4)/(x^2-4) => (4-2)/(4-4) = infinity^~ ~~ infinity^~: So this solution is incorrect Check the solution x = 0. -2/(x+2) => -2/(2+0) = -1 (x+4)/(x^2-4) => (4+0)/(0-4) = -1: So this solution is correct Gather any correct solutions. The solution is: Answer: x = 0
Best ResponseYou've already chosen the best response.0
- 3 years ago
(x+2)*(x+4)=(x^2-4)*(-2) x^2+4x+2x+8=-2x^2+8 3x^2+6x=0 delta=6^2-4*3*0=36 x1,2=[-6+-sqrt(delta)]/6 so x1=0 and x2=-2 so A is the correct answer
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Entry is open for a charity golf day in Winchester
/ News
APPLICATIONS are now open for a popular charity golf day at a Hampshire golf course in aid of a Christian charity on Tuesday May 20.
The Royal Winchester Golf Club in Sarum Road will again host the CAFOD Golf Day with all proceeds going towards overseas development.
The competition is for teams of four but individual applications are welcome.
Full details from 01252 329385 or portsmouth@ cafod.org.uk.
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Chasing Blue Sky HDR by ISIK5Watch
Kumkapı 2009-HDR
simply amazing! holaaaa
... excellent work!
perfect HDR both colors and perceptive
Wow the building looks really old!
very nice ! love it !
well done
DAmn, that is just how I see the environment sometimes. Nice textures and colors
this is just so cool!!!!
lol maybe you do have a wide angle lens? haha either way lovely shot!
Really awesome!!! Excellent, one of my favorites HDR
WOW... Speechless...Astonished
nice photo! where is kumkapi? there is a same place with same name in Greece - creta - Chania ...
reminds me of silent hill! I love it
this is lovely
Wow, this is insanely stunning. So amazing.
Glad you like it and thanx for the
great stuff again.
can you point me to any other [hdr] artists that you might be watching?
can you point me to any other [hdr] artists that you might be watching?
This is really nice. Well done!
did you use an effect on this picture ???
could i know wich one ??
could i know wich one ??


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What does SMHU stand for?
What does SMHU mean? This page is about the various possible meanings of the acronym, abbreviation, shorthand or slang term: SMHU.
We've found a total of 4 definitions for SMHU:
Filter by: Sort by:PopularityAlphabeticallyCategory
Secure Mental Health Unit
Senior Mental Health Unit
Seniors Mental Health Unit
Special Management Housing Unit
Still can't find the acronym definition you were looking for? Use our Power Search technology to look for more unique definitions from across the web!
"SMHU." Abbreviations.com. STANDS4 LLC, 2016. Web. 14 Feb. 2016. <http://www.abbreviations.com/SMHU>.


text:
Flatwound Bass Guitar Strings
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You have a distinct way about you when you get into the groove with your bass guitar, so it only makes sense that you'd want a distinct type of bass guitar string. Flatwound strings, with their unique construction, are almost certainly what you're after. Regardless of your playing style, a set of flatwound strings are definitely going to bring out the best in you and your bass guitar. Like many strings, flatwounds have either a round or hex core. What sets them apart, however, is the fact that their winding wires have a shallow profile when tightly wound thanks, in part, to their rounded square cross sections. This construction style makes them more comfortable to play than the alternatives. Additionally, flatwound strings are known to have longer lives, due to their smaller grooves, which allow less build-up of dirt and oil. Easier playability, plus longer life; it's no wonder you want to string your bass with flatwound strings.
So which flatwound strings are right for you? Well, that's totally a matter of personal preference. If you have a favorite brand, you may want to go with their offerings. If, on the other hand, you have no real preference, you may want to simply check out some of our best sellers and make your decision from there. Options like the ECB82 Chromes Flatwound Medium Bass Strings from D'Addario and the Fender 9050L Stainless Steel Flatwound Long Scale Bass Strings - Medium are two of our more popular strings among bassists, and it's little wonder as to why. These strings offer wonderfully warm tone as well as a smooth playing style. Other popular options include the Rotosound RS77LD Jazz Bass Monel Flat Wound Strings, the Thomastik JF345 Flatwound 5-String Jazz Bass Strings, and the Ernie Ball 2810 Flatwound 5-String Bass Strings Set.
With so many different options, half the fun comes from picking and choosing which strings will best complement your sound. Take a look around, choose a few flatwound options and, most importantly, get out there and start playing! When you find the strings that are perfect for you, you'll know, and you'll never look back.


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Very happy with the color and quality of this rug. I had been searching for quite a while for a 9x12 rug for the master bedroom in our new house with no luck. I found this one on Overstock three days before our scheduled move date. It looked perfect online (price and color) but I was hesitant to make such a large purchase sight unseen, especially as there were no reviews posted. I'm very glad that I took the chance and ordered it. The rug arrived very quickly (on move day) and is absolutely beautiful. The colors are a mix of muted blues and grays, very true to the colors online. I used a rug pad for added insulation, but it really is not needed as the rug is thick and comfortable to walk on. I've had it three weeks, and haven't noticed any shedding or pilling as described in the reviews for other wool rugs. Perhaps it is because I vacuum with the beater turned off. Overall, I am very happy with this purchase,
Rug looks nice and lightens room which was needed. Only complaint is constant shedding of fine, light colored strands. Has not decreased even after frequent vacuuming over time.
I love this rug, it's beautiful. Only downside is that it still sheds quite a bit after a year of use.
Love the rug! Amazing colors. Muted but with an interesting dotted Greek key pattern. I have it on floor with no rug pad yet and it's so plus!


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831 NE Avery Street, Newport, OR 97365 • Ph: 541-265-8571 • Fax: 541-265-3862
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Ambulance service plan debated by commissioners
Modified: Monday, Feb 8th, 2016
NEWPORT -- Lincoln County has an Ambulance Service Area Plan that seeks to ensure prompt emergency response in all areas of the county. The Lincoln County Board of Commissioners, at its meeting on Wednesday, Feb. 3, talked about proposed updates to this plan.
Teachers ready to ratify 3-year labor contract
Modified: Sunday, Feb 7th, 2016
NEWPORT -- Lincoln County School District and its teachers union will finally ratify a new three-year contract during its Board of Directors meeting on Tuesday, Feb. 9.
The board and the Lincoln County Education Association (LCEA) are expected to sign the collective bargaining agreement during the 7 p.m. meeting at Sam Case School.
Two-year helo extension awaits Obama's signature
Modified: Saturday, Feb 6th, 2016
NEWPORT -- Congress has finally approved inclusion of language in the U.S. Coast Guard Act of 2015 that ensures helicopter facilities in Newport and Charleston, S.C., will remain open through 2017.
The bill, which passed the Senate in December and the House earlier this year, will become law following the signature of President Barack Obama.
Vandalism keeps crew busy
Posted: Thursday, Feb 4th, 2016
NEWPORT -- Thousands of dollars are being spent annually in Newport for public facility repairs, rather than building improvements, because of ongoing acts of vandalism in the seaside town.
Building Maintenance Supervisor John Johnston, and his small crew take care of over a dozen city facilities. Summer is the worst time of year for vandalism, Johnston said. But
Sunnier skies on coastal horizon
Posted: Thursday, Feb 4th, 2016
NEWPORT -- A batch of cold and wet weather is forecast to give way to sunny skies and warmer temperatures in the second week of February as a ridge of high pressure moves over the area. But not before the central coast region gets hit with another round of rain and strong wind.
Battered rescuers will be back
Posted: Thursday, Feb 4th, 2016
LINCOLN CITY -- Two lifesavers, who were injured after their Jet Ski was swamped by a rogue wave near Pacific City during the futile search for a missing girl on Feb. 1, can't wait to get back to their dangerous jobs on the state's only certified water rescue team.
North Lincoln Fire & Rescue volunteers Loren Nordyke and Eric Maestas
Fluoridation decision headed to voters
Posted: Thursday, Feb 4th, 2016
NEWPORT -- The Newport City Council again adopted a fluoridation ordinance, along with a resolution on Monday, Feb. 1, that will send the measure to voters in May.
Because the ordinance wasn't read by title only before a roll call vote on Jan. 19, the council's decision had to be ratified.
Public loans cloaked in secrecy
Posted: Thursday, Feb 4th, 2016
LINCOLN CITY -- A $7 million municipal agency that distributes taxpayer-funded loans to "eliminate blight" declined recently to reveal the names of businesses that have received interest-free financing from the city.
An assistant director of the Lincoln City Urban Renewal Agency (URA) rebuffed Mayor Don Williams when he asked about details of two loans during a Jan. 11 meeting of
Yachats seeking first city administrator
Posted: Thursday, Feb 4th, 2016
YACHATS -- Yachats officials will soon be restructuring city operations as councilors and staffers seek the small coastal community's first city administrator.
City Councilor Max Glenn said they decided to search for an administrator because Yachats won't always have Mayor Ron Brean's skill set.
Man gets 84 months prison in child porn case
Posted: Thursday, Feb 4th, 2016
NEWPORT -- A Depoe Bay man was sentenced to 84 months in state prison for using a computer to view sexually explicit conduct involving children.
John Lorentz Wiegardt was sentenced after pleading guilty to five counts of encouraging child sexual abuse in the first degree, and five counts of encouraging child sexual abuse in the second degree.
Iowa outcome weeds out candidates
Posted: Thursday, Feb 4th, 2016
The fallout from the Iowa Caucuses was severe with a number of Republican presidential hopefuls suspending their campaigns, and more likely to follow in the coming weeks.
Kentucky Sen. Rand Paul was one of three GOP candidates to end his presidential bid when he declared Wednesday, Feb. 3, that he was out of the running.
"It's been an incredible honor
'Generous donation' keeps Aquatic Center afloat
Modified: Thursday, Feb 4th, 2016
NEWPORT -- A $300,000 donation to the Newport Aquatic Center will bail the financially plagued project out of a $200,000 excavation overrun, and allow city staff to keep features they would've had to otherwise sacrifice.
Parks and Recreation Director Jim Protiva said a geologist's assessment determined the land in the construction zone was "not compactable," and that the facility would
Teenager missing, rescuers injured at Cape Kiwanda
Modified: Wednesday, Feb 3rd, 2016
PACIFIC CITY -- A 17-year-old girl remains missing after she slipped off a rock and fell into the ocean Monday, Feb. 1, at Cape Kiwanda, sparking a desperate search that nearly took the lives of two rescuers.
Efforts to locate the teenager, Megan Owens of Marysville, Wash., were suspended by the U.S. Coast Guard on Tuesday, Feb. 2.
Ringing up revenue
Modified: Wednesday, Feb 3rd, 2016
NEWPORT -- Hearty doses of good weather made Newport a prime destination for tourists in early fall, in turn producing solid reservation bookings for lodging establishments in the seaside town.
The combination also proved financially beneficial for the city, which collected $145,202.41 in room tax revenue in November, according to data compiled by the finance department. That was up about
County commissioners debate room tax increase
Posted: Tuesday, Feb 2nd, 2016
NEWPORT -- The latest discussion about the future of the Lincoln County Fairgrounds was held Wednesday, Jan. 27, when the Lincoln County Board of Commissioners debated whether to increase the county's transient room tax (TRT).
Such a decision would ultimately be up to Lincoln County voters. "Unlike the cities' authority to impose a TRT increase without a public vote, we
Dredging planned at Port of Alsea
Posted: Tuesday, Feb 2nd, 2016
WALDPORT -- A long overdue dredging of the Port of Alsea's boat basin and launch ramp may occur next winter if the project's permitting process is approved.
The proposal involves removing 30,500 cubic yards of sediment, which would be transported via a 3,000-foot-long pipeline to a beach area southwest of the port.
Local gas prices fall below $2 per gallon
Posted: Tuesday, Feb 2nd, 2016
NEWPORT -- A steep drop in crude oil prices during the past few months is finally showing up at service stations in town with some retailers selling regular unleaded gasoline for less than $2 per gallon.
Two gas vendors in Newport dropped the price of regular unleaded to $1.999 per gallon during the past week.
Building fees could tumble
Posted: Tuesday, Feb 2nd, 2016
LINCOLN CITY -- The costs of construction could drop if elected officials lower building fees known as systems development charges.
On Monday, Feb. 1, city councilors heard a recommendation by an expert to reduce water and sewer SDCs by as much as 30 and 40 percent, respectively.
Man jailed after crashing van into light pole
Posted: Tuesday, Feb 2nd, 2016
NEWPORT -- A Newport man was arrested for allegedly driving under the influence of intoxicants after the vehicle he was piloting left the roadway, and plowed into a light pole and fire hydrant, authorities said.
The incident happened about 7:50 a.m. on Jan. 24 when local resident John Nason apparently lost control of a green 1998 Dodge Caravan while heading
Citizen trumps city's findings
Posted: Tuesday, Feb 2nd, 2016
LINCOLN CITY -- City officials learned recently that their town has topped the charts of pollsters, who track the best places to visit and the worst to live.
Jo Francis Calk, the newest member of the town's library board, revealed her own findings on travel trends even as town elders convened to hear the results of a long-awaited study on
Graduation, dropout rates show improvement
Modified: Tuesday, Feb 2nd, 2016
NEWPORT -- Newport High School compares favorably to statewide high school graduate and dropout rates based on four- and five-year cohorts of students.
The Oregon Department of Education (ODE) released a report last week showing high school graduation dropout rates statewide for the 2014-15 school year.
Yachats council OKs shoreland protection changes
Modified: Monday, Feb 1st, 2016
YACHATS -- Readying for any Land Use Board of Appeals battles that may come, the city of Yachats has gotten more specific with its shoreland protections.
On Jan. 14, the city council voted to approve an ordinance amending the shoreland setbacks section of the municipal code. The planning commission suggested new language that defines specific qualifications for protection.
New Siletz law enforcement plan unveiled
Modified: Sunday, Jan 31st, 2016
NEWPORT -- A proposal for forming a Siletz Area Enhanced Law Enforcement Service District was presented to the Lincoln County Board of Commissioners at its weekly meeting on Wednesday, Jan. 27.
The commissioners were asked to initiate a process to form this district, which would ultimately be put to a vote in May.
Rogue's new warehouse near approval
Modified: Saturday, Jan 30th, 2016
NEWPORT -- After 18 months of negotiations, the proposed expansion plans of Rogue Ales at the Port of Newport are nearing completion.
Approval of a lease agreement between the two entities will be considered when the port's Board of Commissioners revisits the issue at its Feb. 16 meeting.
Fulfilling a need for the homeless
Modified: Friday, Jan 29th, 2016
NEWPORT -- Project Homeless Connect is one of the most visible homeless aid efforts in Lincoln County each year, but the assistance offered isn't just a one-day deal.
The ninth annual event at the Newport Church of the Nazarene on Thursday, Jan. 28 provided services like health care and job assistance, and items such as tents and hygiene products to
Graffiti drawing attention in Newport
Posted: Thursday, Jan 28th, 2016
NEWPORT -- To some, graffiti is a display of artistic expression. To many who live in, or visit Newport, it's a nuisance.
"It takes away from the aesthetic appeal of the beach," said Seth Jones, of Salt Lake City, Utah, who spotted graffiti at Nye Beach.
Council rejects vacation rental moratorium
Posted: Thursday, Jan 28th, 2016
LINCOLN CITY -- Vexed by shifting policies that could reduce the number of nights they can do business and subject them to steep penalties for violating the vague limits, vacation rental homeowners turned out in force earlier this month to plead for relief from the city council.
On Jan. 25, they got their answer when the council blocked a moratorium
Committee interviews barred to public
Posted: Thursday, Jan 28th, 2016
LINCOLN CITY -- Under a new policy approved by the city council, applicants for influential public committees will be interviewed behind closed doors.
Convening at undisclosed locations under the thin shelter of a disputed section of open meetings law, city councilors will select the city's next crop of leaders beyond earshot of the general public.
Gun 'buyback' event returns to Newport
Posted: Thursday, Jan 28th, 2016
NEWPORT -- In an effort to reduce the number of guns in Lincoln County, Ceasefire Oregon will hold its second annual "buyback" event on Saturday, Feb. 6.
The "Voluntary Turn-In of Unwanted Guns" event will be held from 10 a.m. to 2 p.m. at the Newport Police Department, which is a co-sponsor.
Ashland man arrested after car chase across county
Posted: Thursday, Jan 28th, 2016
NEWPORT -- An Ashland man led multiple police agencies on a pursuit from north to south Lincoln County after allegedly kicking a dog on Tuesday, Jan. 26.
Steven Ronald Valencia Jr., 36, was arraigned on 14 charges, including misdemeanor counts of reckless driving, recklessly endangering another person, and animal abuse in the second degree. He appeared in Lincoln County Circuit
Dems in tight Iowa contest
Posted: Thursday, Jan 28th, 2016
Vermont Sen. Bernie Sanders is clinging to a narrow lead over Hillary Clinton in Iowa with a few days left before voters caucus in the Hawkeye State.
A Quinnipiac University Poll released Jan. 27 showed Sanders, a self-described socialist, with 49 percent support from likely Democratic caucus participants, compared with 45 percent for Clinton.
Former Maryland Gov. Martin O'Malley
Port leaders pitch project to Lincoln City
Modified: Thursday, Jan 28th, 2016
LINCOLN CITY -- Top officials with the Port of Newport shared their vision of prosperity with the Lincoln City Council on Jan. 25, arguing that a new era of marine shipping will benefit residents throughout the county.
Port Manager Kevin Greenwood and Walter Chuck, chairman of the port's board of directors, described how nearly $400 million in public and private
New boatyard emerges from a dream
Posted: Tuesday, Jan 26th, 2016
TOLEDO -- Located seven miles up the Yaquina River, the Port of Toledo has proven over the last five years that ambition can turn a trickle into a waterfall.
At the beginning of a five-year project to renovate a dilapidated boatyard the port had purchased, Port Manager Bud Shoemake and his handful of employees must have wondered if they'd ever
Graffiti gets attention
Posted: Tuesday, Jan 26th, 2016
A man and woman take notice of graffiti recently painted on the walls of the Nye Beach Turnaround on Monday, Jan. 25, in Newport.
Storm damage totals $2.9 million
Posted: Tuesday, Jan 26th, 2016
NEWPORT -- Lincoln County officials are seeking financial assistance with $2.9 million in public infrastructure damage after a series of storms pounded the area in December.
The Federal Emergency Management Agency (FEMA) and Oregon Emergency Management completed public Preliminary Damage Assessments (PDA) in 13 Oregon counties earlier this month. The agencies also completed individual assistance damage estimates in six counties,
Initiative supporters spar with city
Posted: Tuesday, Jan 26th, 2016
LINCOLN CITY -- Organizers of an initiative petition to replace the city's contested vacation rental dwelling laws are engaged in a back and forth legal battle with the city attorney.
Citing technical flaws, City Recorder Cathy Steere, the city's chief election officer, repeatedly disallowed a trio of ballot titles that petition supporters hoped to place on a May special election
Newport passes fluoridation ordinance for voter approval
Modified: Tuesday, Jan 26th, 2016
NEWPORT -- Due to a technicality, city councilors will have to readdress a recently approved fluoridation ordinance in order to send it to voters in May's special election.
On Jan. 19, the Newport City Council talked in length about language revisions, deciding upon a handful and casting a vote in favor of the ordinance, 4-1.
Man arrested after alleged car break-in
Posted: Tuesday, Jan 26th, 2016
EDDYVILLE -- A man from Dallas, Ore., was arrested earlier this month after being scared off the property of two Eddyville residents with firearms.
Jeffrey A. Rodgers, 22, was indicted on charges of unlawful entry into a vehicle, criminal mischief in the second degree, and attempt to commit a Class C felony in Lincoln County Circuit Court on Jan.
Banned bedroom leads to VRD appeal
Posted: Tuesday, Jan 26th, 2016
LINCOLN CITY -- The first test of Lincoln City's authority over vacation rental dwellings in Roads End, annexed to the city in 2013, is underway at the Oregon Land Use Board of Appeals.
An agreement to postpone the application of Lincoln City's vacation rental laws for five years after the takeover failed to prevent regulators from barring the use of
City audit has PERS strings attached
Posted: Tuesday, Jan 26th, 2016
DEPOE BAY -- An otherwise rosy financial report turned bleak for city councilors when an auditor revealed earlier this month that nearly a half-million dollars of unfunded Public Employee Retirement System benefits would skew future municipal balance sheets.
A new federal rule of the Government Accounting Standards Board, known as GASBY 68, requires all public entities to list the full
Highway devours asphalt
Posted: Tuesday, Jan 26th, 2016
BEVERLY BEACH -- Road workers on Friday, Jan. 22, plugged a fast-growing sinkhole on a notorious stretch of road that keeps repair crews busy year round.
"This is what we call job security," beamed Todd Perryman, a roller operator with Road and Driveway Co. of Newport, a subcontractor for the Oregon Department of Transportation. "We've already been out here a
Trailer park ruckus ends in arrest
Posted: Tuesday, Jan 26th, 2016
DEPOE BAY -- A shotgun-wielding man put a round through the grill of his girlfriend's car in a last-ditch effort to keep her from leaving him, but the gambit backfired when he was arrested on weapons and drug charges after the Friday, Jan. 22, incident.
A small group of police officers, firefighters and ambulance personnel responded to a 10:44 a.m.
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text:
When will electricity be too much? When would you shut off your running water?
Originally posted by GrimReaper86
reply to post by BooKrackers
all the more reason to start growing food at home if you can...
Originally posted by GrimReaper86
Thanks for the number. $20 feel pretty far off right now. Let's hope it stays that way.
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text:
|Shahid Modhej Power Plant(Zargan)
The Shahid Modhej Power Plant is located at 9th kilometer of the Ahwaz – Masjedsoleyman Road and in the east north of the Ahwaz city. The contractor of the steam units was British GEC and the ACEC form Belgium built the gas units.
|After signing the contract with the South Korean Dewoo Corporations in 1990, the Tavanir Company started reconstructing the power plant after the 8-years war between Iran and Iraq. At the 1992 the second steam unit was completed with the efforts of the Tavanir Company and it joined the whole country electricity net in 1993.
The water used in the power plant is taken from the Karoun River and this is don e by auxiliary pumps in the case of low water level. The power plant itself, was invaded five times during the 8-years war between Iran and Iraq.
|The steam unit turbine is designed for 121bar pressure in the 540C temperature and is installed horizontally. The turbine has a high pressure cylinder involving 15 stages and a low pressure cylinder with six stages (Double Flow Stages).
The ultimate vacuum rate in the condenser is 0.0898.


text:
Blueberry season is well underway and since I'm a big fan of these little blue gems, I'm trying to find as many ways as possible to work them into some delicious recipes. Sure, I could totally just eat them by the fistful straight out of the little basket, but why not explore new recipes that utilize this sweet summer berry?
Over the weekend, I picked up a mass quantity of locally grown blueberries and knew that I wanted to create a simple lemon infused homemade blueberry sauce for a recipe that's coming up tomorrow. But this sauce was so incredibly tasty, that I couldn't just stop there. As the weekend progressed we were adding a dollop of this homemade blueberry sauce to freshly churned vanilla ice cream, graham crackers and breakfast pancakes.
This sauce is sweet with a hint of tartness and adds the perfect little something extra to anything it comes into contact with. Okay – maybe not anything, so don't go slathering this on Beef Jerky expecting something epic.
Stay tuned to tomorrow's post and find out what I did with this homemade blueberry sauce that created one of the easiest and tastiest recipes that I've made in recent weeks.
Yield: about 8 servings


text:
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Alastair Keatinge
Alastair Keatinge is trustee at Edinburgh's Civic Trust - the Cockburn Association, and head of charities at law firm Lindsays WS.
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