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It looks like the casting odds were ever in her favor as the Power Rangers movie locks down Elizabeth Banks (The Hunger Games, The LEGO Movie) to play Rita Repulsa. Banks tweeted the announcement earlier today and already shows signs of getting into character. While she was always colorful and proper as Effie Trinket in The Hunger Games, Rita Repulsa will require Banks to really let loose. (more…)
Elizabeth Banks
Pitch Perfect 2 was one of the hits off summer, and though it hardly scored Jurassic World numbers, it has collected almost $184 million domestically since its May release and has a passionate fanbase. Not bad for a first time director. Elizabeth Banks is very well-known for her work as an actress in flicks like The Hunger Games, Role Models, The 40 Year Old Virgin and the recent Love & Mercy, but now she's making a play to be a well-known director. Her next project, apparently, is a remake of the 1970s TV hit Charlie's Angels, but the more compelling question is what direction is she going to take the franchise in? (more…)
Congratulations to the three of you who got that joke in the headline. But now that it's out of the way, it's time to get serious about the third film in The Hunger Games franchise, Mockingjay Part 1. Six new character posters have been released to promote the film, featuring a look, but not a vast look, at the formally mythical 13th District of Panem. There's a definite aesthetic to design of these posters, and even not so careful observers will see that there are a couple of characters missing from this collection. What do I mean, and who's missing from this latest round of posterization? Check out the gallery below. (more…)
The Hunger Games lit a spark, but its sequel Catching Fire is what will set the world ablaze. Performing better than any sequel in recent memory, Catching Fire gives audiences exactly what they want: bigger, better, and more. Director Francis Lawrence isn't looking to reinvent the wheel with this movie, but it's obvious special attention was paid to resolve the gripes made about The Hunger Games. The cast, Jennifer Lawrence in particular, all give exceptionally strong performances, clearly having grown more comfortable in their roles. Sequels are meant to satisfy our burning need for more of what we loved the first time around, and sometimes setup forthcoming sequels; Catching Fire does this all, and then some. (more…)
A second trailer has released for The LEGO Movie, so if somehow the first one didn't get you amped to see this hilarious look at the world of multicolored bricks, then there's no hope for you. You'll never understand the joy of tiny plastic Batman failing, repeatedly, to throw a batarang. (more…)
First Trailer for 'The LEGO Movie' Has it All: LEGO Ninjas, LEGO Superheroes, & Two LEGO Michelangelos
Mimicking the gimmicks from any dozen blockbuster trailers, The LEGO Movie not only promises an adventure as big as you can build it, but laughs spanning the generations of LEGO architects. Starring Parks and Recreation's Star-Lord, Chris Pratt as the little LEGO fella, Emmet, who's mistakenly tasked with saving the world, The LEGO Movie is directed by Phil Lord and Chris Miller (Cloudy With a Chance of Meatballs) from the screenplay they developed with writing duo, Dan Hageman and Kevin Hageman (Hotel Transylvania). Which is some grade-A animated comedy pedigree right there.
I was bustin' up laughing just as the trailer, so I feel confident saying the movie's gonna be a hit. I mean, one, who doesn't love LEGOs, and two, who doesn't love obscure call backs like 1980-something space guy? Plus, what a dream team: 2002 NBA All-Stars along wither Superman, Wonder Woman, Michelangelo the Renaissance painter, and Michelangelo the Teenage Mutant Ninja Turtle. All makes me want to break out the LEGOs right now!
Featuring the voices of Chris Pratt, Will Ferrel, Elizabeth Banks, Will Arnet, Morgan Freeman and Liam Neeson, The LEGO Movie releases next year, February 7th, 2014.
Source: Screen Rant
As a nice tie-in with the opening events of The Hunger Games' sequel, Catching Fire, which feature the winners of the 74th Hunger Games parading through the districts on a victory tour, Lionsgate have released these victory portraits of Elizabeth Banks' Effie Trinket, Stanley Tucci's Caesar Flickerman, Woody Harrelson's Haymitch Abernathy, Lenny Kravitz's Cinna, and of course, Jennifer Lawrence as Katniss.
UPDATE! The Hob has unveiled the portrait of Beetee (Jeffrey Wright).
UPDATE #2! Moviefone shared the portrait of Johanna (Jena Malone).
UPDATE #3! ET Online has finally released two of the most eagerly awaited portraits, Peeta (Josh Hutcherson) and Gale (Liam Hemsworth).
UPDATE #4! Ladies and gentlemen, the latest portrait has been released via MTV and it's sure to have fans everywhere swooning, Finnick Odair (Sam Claflin).
UPDATE #5! Another portrait hits the web via Yahoo! Movies, this one of President Snow (Donald Sutherland),
I think they're stunning, what do you think? And is that Katniss' Mockingjay dress or another?
The Hunger Games: Catching Fire begins as Katniss Everdeen has returned home safe after winning the 74th Annual Hunger Games along with fellow tribute Peeta Mellark. Winning means that they must turn around and leave their family and close friends, embarking on a "Victor's Tour" of the districts. Along the way Katniss senses that a rebellion is simmering, but the Capitol is still very much in control as President Snow prepares the 75th Annual Hunger Games (The Quarter Quell) – a competition that could change Panem forever.
Directed by Francis Lawrence and also starring Josh Hutcherson, Liam Hemsworth, Donald Sutherland, Toby Jones, Jena Malone, Philip Seymour Hoffman, Amanda Plummer, Lynn Cohen, Patrick St. Esprit, Meta Golding, Bruno Gunn, Alan Ritchson, E. Roger Mitchell, Maria Howell, Stephanie Leigh Schlund, and Sam Claflin.
The Hunger Games: Catching Fire opens November 22nd, 2013.
We'll update as more portraits are released!
Source: Geek Tyrant
Lionsgate has released a (slightly) spiffy animated poster for it's Hunger Games sequel Catching Fire. It was unlocked by HG fans on Facebook. Apparently, if you creep FB long enough, you get an animated logo for a teaser of a teaser of a trailer of a trailer…
OMG guys, it's a logo, let's check it out right fucking now!
Take half of the Farrelly Brothers (Peter Farrelly), mix in a whole pack of other directors (Elizabeth Banks, Steven Brill, Steve Carr, Rusty Cundieff, James Duffy, Griffin Dunne, Patrik Forsberg, James Gunn, Bob Odenkirk and Brett Ratner) and an astonishingly large cast of famous faces (I'm not going to list them all, just watch the trailer and you'll recognize everyone) and what do you get? A movie that looks far funnier than I think any of us expected. The true cinephile will recall classic comedy anthology movies like Kentucky Fried Movie, Amazon Women On The Moon and The Groove Tube, and by the looks of it, Farrelly intends to resurrect the genre with Movie 43.
Hot damn does it look funny. Check the trailer out below, but be warned it is very NSFW due to f-bombs and nudity. Yes, the Movie 43 trailer, come for the nudity and Kate Winslet cursing, stay to be inspired by Terrence Howard.
Warner Bros. is adding a touch of Oscar-calibre class to its upcoming LEGO movie, casting Morgan Freeman as one of the voices in the upcoming animated feature. Hunger Games star Elizabeth Banks has also signed up for the film to provide a voice as well.
The film is called LEGO: The Piece of Resistance, and it's being directed by Cloudy with a Chance of Meatballs and 21 Jump Street filmmakers Phil Lord and Christopher Miller. The plot follows an ordinary Lego mini-figure, mistakenly thought to be the extraordinary MasterBuilder, who is recruited to join a quest to stop an evil Lego tyrant from gluing the universe together. The cad!
Freeman will play "Vitruvius," who is described as a cross between "Gandalf meets Mr. Magoo," while Banks will play the "badass ex-girlfriend" of another character that will be voiced by Chris Pratt. Arrested Development actor Will Arnett rounds out the rest of the announced cast so far as as the voice of LEGO Batman.
The 3-D animated film is aiming for a February 28, 2014 release date.
Source: Geek Tyrant


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Isn't this the cutest little stamp? Only 99 cents too! I bought one for myself and one for each of my flip flop gal pals! We all love to wear our flip flops all summer long, now we can walk across our lay-outs with our flip flops too! So cute!
Can't have enough shoes, especially flip flops! What a fun stamp for all the beach and pool pages this summer. I chose sand colored paper and made it look like the shoes were walking in the sand along the water on my beach sunset page.
ok.. these stamps are soo cheap in cost and as many times as I will use them they are well worth the small amount. They are fun, give a clear image when stamped and can be cut apart to use in many different ways.
Great construction and quality. Adorable stamp. Great for cards (as well as scrapbooks)!

subset: commoncrawl


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Prices, specials, features and availability subject to change.
Contact for details
A perfect community to call home!
Discover peaceful apartment home living in Springfield, Ohio at Red Coach Village Apartment Homes. Red Coach Village Apartment Homes is an outstanding apartment community located in Springfield, Ohio. These spacious one, two and three bedroom apartment homes feature a variety of well-appointed floor plans. Set on professionally-maintained, landscaped grounds, our pet-friendly community also has excellent transport links. Minutes from Highway 72, US-68 and Buck Creek State Park, Red Coach Village Apartment Homes is located near the best in dining, shopping and entertainment. Visit Red Coach Village Apartment Homes in Springfield, Ohio today!
Lease Terms: 1-12 months, length of lease can be determined by move in date. Pet Policy: Maximum number of pets 2, some breed restrictions. Restricted Dog Breeds: Pit Bull, Doberman, German Sheppard, Rottweiler, Chow, Mastiff, Bull Terrier, American Staffordshire Terrier, Komodor and mix of any of the breeds are not permitted. Call for more information.
Pets Accepted. Breed Restriction. Call for service animal policy.
136 units
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The staff, especially Leslie, were very accommodating and willing to assist in any way to make our time at Red Read More Coach enjoyable
December 27, 2013
Pros: Great apartments, 24 hour maintenance was great, landscaping and overall look of the area was wonderful Read More.
Cons: Rent being raised every year for no reason, office staff were very unprofessional and not mentally equipped to handle residents, and availability of staff was unacceptable (walked over many times to pay rent and no one was in the office during work hours).
December 25, 2013
Apartments are antiquated and poorly upkept. All windows let in a ton of cold air, and the furnace runs const Read Moreantly. Vice versa in the summer with the A/C. Lots of insects in the apartment due to poor caulking around windows. Numerous maint issues, that takes them forever to get to, and when they do, they rarely fix it right. Office staff tends to say they will address issues, but never does, such as issues with neighbors breaking rules, noise, people throwing parties and taking all the parking.
December 17, 2013
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Legislation to raise the nation's $14.3 trillion debt ceiling became law Tuesday after the Senate easily approved it in a 74-26 bipartisan vote.
President Obama signed the measure without ceremony shortly after receiving it, with the White House announcing the news via Twitter. No members of Congress attended the signing of legislation, which will cut federal spending by $2 trillion over the next decade and raise the nation's borrowing limit through the 2012 presidential election.
Forty-five Senate Democrats joined 28 Republicans and one Independent in supporting the measure, one day after most of the House GOP voted to approve the package.
Lawmakers in both chambers on Tuesday were already turning their attention to who will be appointed to a new committee created by the law and charged with assembling an additional $1.5 trillion in deficit cuts.
Democrats are quickly falling into two camps. Some liberals want their leaders to sit on the committee and defend their party's cherished programs. Other Democrats want "new faces" on the panel who will be more likely to reach a comprehensive budget-cutting agreement with Republicans.
Republicans, meanwhile, are divided between those who are willing to reduce the deficit through tax-code reforms and those who want to take a hard line against any possible tax increases.
So far congressional leaders, who have two weeks to make their selections to the 12-member bicameral panel, are keeping their calculations secret.
The joint committee is the brainchild of Senate Majority Leader Harry Reid (D-Nev.), who introduced it during debt-limit negotiations with Senate Republican leader Mitch McConnell (Ky.) and House Speaker John Boehner (R-Ohio).
Reid, McConnell, Boehner and House Democratic leader Nancy Pelosi (Calif.) will each make three selections to what is being called the "super committee."
More from The Hill:
♦ LaHood's effort fails to end FAA furloughs
♦ Patent reform bill on Senate agenda after recess
♦ Salazar, Murkowski head to Alaska ahead of spending bill fight
♦ Top HHS officials to take over exchanges office
Reid drew a line in the sand Tuesday by declaring that if the committee did not agree to raise additional tax revenues, a broader deficit-reduction package would not pass this Senate. If the committee fails to produce a budget-cutting plan worth at least $1.5 trillion that can pass Congress, it would trigger up to $1.2 trillion in automatic spending cuts, divided evenly between defense and non-defense programs.
Democrats are betting that the prospect of huge defense cuts will give Republicans incentive to agree to ending corporate tax breaks to reduce the deficit.
Reid said he would pick members with "open minds," and urged GOP leaders to do the same.
"The members, I say here, must have open minds," Reid said. "We've had too much talk the last few days of Republicans, as early as this morning, Republican leaders in the Senate saying there will be no revenue. That's not going to happen. Otherwise, the trigger is going to kick in."
McConnell told reporters Tuesday afternoon that he will work with Senate Republican Whip Jon Kyl (Ariz.) to choose the Senate GOP's representatives on the joint committee.
Many lawmakers are skeptical the committee will reach agreement by its deadline of Nov. 23, but McConnell expressed optimism. "The joint committee is not going to gridlock, in my opinion," he said. "The joint committee is designed to function and to tackle some of the very difficult problems that we have been unwilling or unable to deal with."
McConnell downplayed the prospect of the committee recommending tax increases, a fear of many conservatives in both chambers whose suspicions are heightened by the fact that the idea for the panel came from Democrats.
At a press conference Tuesday, Pelosi said she would appoint members who strongly oppose cuts to Social Security, Medicare and Medicaid.
"Let me say it is more than a priority. It is a value," she said of protecting entitlement programs. "It's an ethic for the American people. It is one that all of the members of our caucus share, so that I know that whoever's at that table will be someone who will fight to protect those benefits."
The hard-line stances Republicans have taken against tax increases and Democrats have adopted against entitlement reforms have fueled skepticism about the special panel reaching agreement.
Some lawmakers speculate that Reid might appoint Senate Finance Committee Chairman Max Baucus (D-Mont.) and Appropriations Committee Chairman Daniel Inouye (D-Hawaii). Reid appointed them to deficit-reduction talks with Vice President Biden and GOP leaders earlier this year. It could be viewed as a slight to those chairmen if they were left out of major talks affecting spending and tax decisions that fall squarely in their jurisdiction.
Some veteran lawmakers want members of the Senate leadership to sit on the special committee, to ensure that its decisions take into account the priorities of the entire Democratic Conference.
"It should be the leadership of our caucus, it shouldn't be committee chairmen," Sen. Tom Harkin (D-Iowa) said. "It should be the leadership of our caucus who is responsible to our caucus, and not to a committee."
Harkin said committee chairmen would be too worried about protecting the parochial interests of their committee to represent the broader concerns of the Democratic Caucus.
He said Senate Democratic Whip Dick Durbin (Ill.), Democratic Policy Committee Chairman Charles Schumer (N.Y.) and Democratic Conference Secretary Patty Murray (Wash.) should sit on the panel.
Baucus declined to say whether he wanted to sit on the panel.
"All truth is good to know, but not all truth is good to say," he added, quoting an African proverb.
More junior Democrats want Reid to appoint lawmakers who are likely to strike a broad compromise, such as the members of the Senate's Gang of Six.
"I'd like to see people on both sides who are looking for a solution," said Sen. Michael Bennet (D-Colo.).
Sen. Tom Udall (D-N.M.) said, "I'd like to see some new faces so we can break the gridlock."
Senate insiders suspect that McConnell will not appoint Sen. Orrin Hatch, ranking Republican on the Senate Finance Committee, who is facing a Tea Party challenge in Utah's Republican primary next year.
Hatch has already taken a strong stance against eliminating corporate tax breaks, arguing it would be harmful when the economy is still weak.
Hatch said he could take or leave the assignment, predicting that he would have an important role in the debate because of his position on Finance.
"That's up to the leader," he said. "I can live with it or I can live without it."
Sen. Mark Warner (D-Va.), who helped found the Gang of Six, said he would like to serve on the panel but doubts Reid will appoint him.
"I don't expect to be," he said.
"All the leaders are going to be under enormous pressure to put folks on that will operate under certain parameters," Warner said, hinting at pressure from labor unions and liberal groups to appoint members who will staunchly oppose entitlement cuts.
—Josiah Ryan contributed to this report.
This story was posted at 12:18 p.m. and has been updated.


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Kurt Schaefer
Sponsored By
Lawmaker Opposition Casts Doubt on New St. Louis StadiumStadium task force co-chair Dave Peacock counters: plan must "make sense and provide benefit for all."
Columbia Lawmakers React to Bill that Would Prohibit City Bag Bans, FeesColumbia may be the first city in Missouri to ban single-use plastic bags, and most of the city's legislative delegation is against the proposed ban.
State Rep Calls for Investigation of McCullochA St. Louis state representative is calling for an investigation of St. Louis County Prosecutor Bob McCulloch, by the same Senate committee investigating Gov. Jay Nixon's response to Ferguson.
Nixon May Face Subpoena About Decisions Made in FergusonThe chair of a joint legislative committee vows an aggressive investigation into why Missouri's governor did not use National Guard troops to protect businesses in the aftermath of the grand jury decision not to indict a Ferguson police officer.
Mark Reardon: The Anniversary Of 9/11Thirteen years ago today, the world changed at 8:46 am Eastern time. CBS News Transportation Safety Analyst Mark Rosenker was in charge of security as President Bush traveled on Air Force One that day and was inside that Florida elementary school with the President when he learned of the terrorist attacks.
Could Mo. Gun Rights Proposal Cost The State?Auditor Tom Schweich raises the possibility
Nixon Urges Legislature to Accept Medicaid ExpansionWith only a couple of days left in the legislative session, Gov. Jay Nixon is holding out hope for one of his most critical issues.
Missouri Senate Backs Education Funding IncreaseThe Missouri Senate endorsed a budget plan Monday that ensures a funding increase for public education but will require negotiations with the House to hammer out the final specifics.
Missouri Lawmakers Pass Criminal Code OverhaulThe legislation would create new classes of felonies and misdemeanors, and it would reorganize crimes to fit the new penalty structure.
Mark Reardon: Bloomberg News Correspondent Johnathan Allen Discusses His Hillary Clinton BookBloomberg News correspondent Johnathan Allen discusses his new book, "HRC: State Secrets and the Rebirth of Hillary Clinton."
Mo. Lawmakers, Governor $370M Apart On BudgetMissouri lawmakers could have to cut about $370 million from Gov. Jay Nixon's budget if they don't want to go along with his financial assumptions.
Missouri State Secretary Creates Voting Complaints GroupSecretary of State Jason Kander established a new program he said is meant to protect Missouri elections and Missouri voters' rights Tuesday.


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Giants in South Africa - by Michael Tellinger
- Uploaded by Paranormalo on Nov 17, 2013
- Views: 217
Professor Francis Thackeray shows Michael Tellinger and friends the rarely seen part of the upper leg bone with hip joint of a giant that would have stood about 12 feet or 3,5 metres tall. This bone has been in the vaults of of the medical school at WITS University, Johannesburg since the early 1960s, when it was found by miners in a mine in northern Namibia. It is one of the most precious and rare specimens available today that clearly indicate the existence of giants in Southern Africa more than 40,000 years shares this video clip as part of his continued research into the origins of humankind, the vanished civilisations of southern Africa and the strange anomalies we discover on this journey.


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Discover a selection of top forums rebornshadow speak on the internet. Come to share your passion on forums rebornshadow speak and meet other fans of rebornshadow speak. Then, why don't you create your own forum of rebornshadow speak ?
Where all are free to think, speak, and act as they wish
james, gang, grill, free, #speak, think, cars, history, news, movies, politics, debate, cooking, comedy


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Correct me if I am wrong John, but is this a portrait of your daughter, the beautiful little girl on the beach? Samantha
Hi Samantha, Well done to spot this. She is indeed the same "little girl on the beach", just six years older.
Best wishes, John
What a beautiful young lady! A truly lovely portrait!
Regards, Julie
Thank you Julie, I appreciate your comments and I am sure Amanda will as well.
Best wishes, John
I can't stop watching this gorgeous portrait, John. She is a beauty, and you made a great job!
Kindest regards from Chile.
Thank you Erwin. I was donig a bit of experimenting with slow flash to try and balance the lighting and was pleased with the result.
Best wishes from Indonesia, John
Thanks for the explanation, John. I give you a star ;)
Thank you for the star Erwin.
Cheers, John
She is pretty. It seems your hand are shaking.
Is she a celebrity?
Cheers, Jeff
Hi Jeff, This is my daughter Amanda. The shake was due to experimenting with a slow flash setting to try to balance the daylight outside with the flash and still look natural. The camera should have been on a tripod.
Thanks for the description.
Hey John you old @%&@!! , You certainly got the chemistry right. You'd best start cleaning the shot gun because she is a stunning young lady. Keep well, Dereck
Hey Dereck, Thanks for your kind comments. I am keeping a good eye on her.
Hope you had a great Christmas.
Greetings from New Zealand, John
Hello John this is the first picture of you I ever see. The beauty here is your daughter Amanda as I understood. Great picture with wonderful soft light and of course a gorgeous model. I'm going to check out some more pictures at your gallery.
Greetings, Erik
Hello Erik, Thank you for your visit and all your kind words. Amanda is also happy to hear your comments.
Very best wishes to you for the New Year, John
She certainly is a beauty John. I need to check on the one of her as a little girl :)
Does she look like you then? ;-)
Greetings, Amelia
Hello Amelia, thanks for your kind comments. Amanda will appreciate it. Don't think I can say she looks like me but I really can't tell.
Greetings, John
Domi, many thanks for your lovely comments.
Best wishes, John


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Chevrolet Avalanche 2500 Repair and Maintenance
A guide to problems, costs, maintenance and repair for your Chevrolet Avalanche 2500
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Ask a mechanic in our community
Never overpay. Check prices with our estimator
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Chevrolet Avalanche 2500 Problems
The 4WD transfer case encoder motor position sensor or the selector switch may fail causing the service 4WD message to be displayed. Fault code(s) stored in the transfer case control module will be of assistance in determining the exact fault causing the message to be displayed.
The muffler heat shield may become loose on the muffler causing a rattle or popping noise. Our technicians tell us there is a kit available from GM to correct this problem.
Illumination of the Check Engine Light can be caused by a loose or worn gas cap.
Chevrolet Avalanche 2500 Questions
Hard to keep vehicle in it's lane, tends to wander all over road, first to one side then to other side after steering correction is made.
It dies out while on freeway and sometimes at stop signs
Put it in 4h to drive through some mud now I can't get it back into 2h. Have pushed the buttons both the 2h and auto, moving, in neutral, in drive everything... stuck in 4H and drives hard on the road.
Chevrolet Avalanche 2500 Recalls
The retainer clip for the fuel rail pulse damper may fracture and allow the damper to come loose from the fuel rail. A fuel leak in the presence of an ignition source may result in a fire. Dealers will replace the engine fuel rail pulse damper free of charge. The recall began August 31, 2006. The GM recall number is 06080.
The tire and loading information label on the driver's side door frame may be inaccurate. A misprinted label could lead to overloading of the vehicle, which could possibly lead to tire failure and a crash. Owners will be provided with corrected labels and installation instructions. At customers' request, a dealer can install the label for them. The recall began March 31, 2006. The GM recall number is 05109.
Chevrolet Avalanche 2500 Reviews
good vehicle didnt think I would like it so much stepped down from a 2500 suburban 6.0 and dont miss it.
Almost indestuctable. Comfortable plus great ride.


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Aliases for PRKCQ Gene
Aliases for PRKCQ Gene
External Ids for PRKCQ Gene
- Entrez Gene: 5588
- Ensembl: ENSG00000065675
- UniProtKB: Q04759
Previous GeneCards Identifiers for PRKCQ Gene
Summaries for PRKCQ Gene
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]
GeneCards Summary for PRKCQ Gene
PRKCQ (Protein Kinase C, Theta) is a Protein Coding gene. Diseases associated with PRKCQ include gastrointestinal stromal tumor. Among its related pathways are PI-3K cascade and Glioma. GO annotations related to this gene include identical protein binding and ubiquitin-protein transferase activity. An important paralog of this gene is PRKCB.
UniProtKB/Swiss-Prot for PRKCQ Gene
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates to the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response. Upon TCR stimulation, mediates T-cell protective survival signal by phosphorylating BAD, thus protecting T-cells from BAD-induced apoptosis, and by up-regulating BCL-X(L)/BCL2L1 levels through NF-kappa-B and JUN pathways. In platelets, regulates signal transduction downstream of the ITGA2B, CD36/GP4, F2R/PAR1 and F2RL3/PAR4 receptors, playing a positive role in outside-in signaling and granule secretion signal transduction. May relay signals from the activated ITGA2B receptor by regulating the uncoupling of WASP and WIPF1, thereby permitting the regulation of actin filament nucleation and branching activity of the Arp2/3 complex. May mediate inhibitory effects of free fatty acids on insulin signaling by phosphorylating IRS1, which in turn blocks IRS1 tyrosine phosphorylation and downstream activation of the PI3K/AKT pathway. Phosphorylates MSN (moesin) in the presence of phosphatidylglycerol or phosphatidylinositol. Phosphorylates PDPK1 at Ser-504 and Ser-532 and negatively regulates its ability to phosphorylate PKB/AKT1.
Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Classical or conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive novel PKCs (nPKCs epsilon-, delta-, theta- and eta- isotypes) are also activated by DAG and phosphatidylserine. The atypical PKCs (aPKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbol esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain via a hinge region. The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation of multiple target proteins, which are involved in signal transduction pathways including, but not limited to, receptor desensitization, modulation of membrane structure events, regulation of transcription, regulation of cell growth, immune responses, and in learning and memory.


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Freedom of Choice Choosing Equality
by Carl E (Jones) Willis
This book, a pictorial tribute, is not meant to be an historical account of school desegregation in Lawton, Oklahoma. The purpose of this book is to remember our past and pay tribute to an unheralded generation of African Americans who as high school students, seeking equality in public school education, voluntarily choose to enroll in formally white only Lawton Senior High School, under the school board's Freedom of Choice Plan.
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Published June 28, 2011
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Stencil by kristrappeniersWatch
©2011-2016 kristrappeniers
Handcut stencil
Wonderful work!
HOW did you spend this long?
Wow! You are patient...
nice work and good inspiration for mine...what kind of paper do you use?? tnx!!
simply wow.. you are the king of the carve!!
I can't believe my eyes! @_@ it's amazing!
It's beautiful! I love the lines <3
Beautiful! I love the hair and ear.
Ridiculous! And by that I mean amazing, and by amazing I mean... whoa... especially if you do all the designing by hand without computer aid.
This is mind blowing stuff. May I ask what sort of material this is cut from?
WOW! all with an x-acto knife??? Very impressive!


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BB Chair Covers Wedding&Event Design-Chicagoland
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Biggest Mistake of my WeddingReviewed on 3/23/2015
I worked with the owner, Goran, whom I met at a bridal expo. His prices for chair covers and sashes were considerably less than other places, so we made an appointment to meet and discuss my wedding plans. He was helpful and professional at our meeting, so we decided to use... Read More him for our linens and centerpieces as well. Biggest mistake of my wedding. He arrived an hour late to set up the day of my wedding, which wasted the money I had spent renting the venue for an extra hour of set-up time. He came alone, ONE person, to set linens, chair covers with sashes, and centerpieces for 150 people. I had to delay the start of my ceremony because the room wasn't ready. I had to ask family members and people in my wedding party to run around and help him fold napkins because he was so behind. In the minutes before I walked down the aisle I was forced to worry about missing table settings and crooked chair sashes instead of the vows I was about to take. I had to pay the shuttle service extra money to run the shuttle buses later to accommodate the delay. THEN, at the end of the night, clearly feeling no shame for his earlier tardiness, he was 2 hours late to pick up the rentals, which made me forfeit $300 of my deposit to the venue. He accidentally took an expensive sweetheart tablecloth we had rented from another rental service with him at the end of the night, which we were stuck paying for. That night he promised he would refund me money for his actions. He has never returned any of my texts or phone calls since. It's been 4 months. In the end, our wedding was happy, loving, and beautiful. When I think back on that special day, Goran is not a part of my memories. My family and friends made sure that everything got done and reminded me what was really important about the day. BUT, I would hate for another bride to go through any of that. Hence this review. Please don't give this guy your business. His rates are better, but it's just not worth it. Goran, if you read this and would like to do the right thing and compensate us (or even just apologize), we would appreciate it.
Great vendor...Reviewed on 10/07/2013
We used the vendor because of our friend's recommendation, and ended u being very happy with our choice. It was very easy to deal with them, and everything went smoothly from the beginning to the end.they had so many choices, and when I saw their candelabras I new that was it.... Read More We used them for our ceremony and reception decorations and would definitely recommend them to everybody.
Great Service and Quality!Reviewed on 10/21/2012 Alicia R
I used BB Chair Covers for my reception. I used the standard chair covers with Navy bows...everything looked great when we walked into the room. The Sales Manager is very professional and they will offer you a great price. I looked into a lot of vendors for chair covers and I... Read More am so glad I went with BB Chair Covers!


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Pages and Places Book Festival
Pages & Places, Scranton's inaugural book festival, brings to the city's downtown 30 writers, scholars, and editors, nearly all of them bearing significant national reputations. The mission is to to promote books, reading, writing, and literacy. Panels may address topics such as movements in contemporary poetry, independent publishing, and urban livability and economic development.


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Reviews For Thorogood Boots 804-4037
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Thorogood Boots: Men's Composite Toe 804-4037 ESD Non-Slip Work Boots
4 out of 4 people found this product review helpful.
Great product for a great price!...
By: htiekdg
I am a big guy and so far these have been a very comfortable pair of boots. They look to be very well made and rugged. I like the fact that they are composite toe as well that way it cuts down on the weight of the shoes drastically. I would definitely recommend this product and will be back when it is time to purchase another pair.
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very cofterrible from day 1...
By: bill
I like them, I would buy again, Thorogood boots are the best, bin wearing Thorogood boots for the last 5 years, love their boots. Only bad thing about these boots is that they are not made in the USA.
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Learn how to grow your own food, rear animals and cook. The courses cater to all skill levels and provide the opportunity to learn from organic farmers with personal experience - from a one-day basic introduction to more professional expertise - in bee-keeping, chicken keeping, vegetable growing, willow weaving, hedge laying and many others.
Whether you want to skill-up and make that step towards making your life more sustainable, learn how to live closer to the land, or get inspired and try something out as a possible career option, this is a great opportunity to try something new as well as have a fun day out on an organic farm.
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You can be part of an amazing movement which is taking action to change the way people think about food and farming.
Starts: 02 March 2013 10:00
Ends: 02 February 2013 14:30
Abbey Home Farm, Burford Road, Cirencester GL7 5HF
Vibrant colours, bold spices and full flavours capture the truly wonderful cuisine of Morocco. In this class we will gain insight to the enchanting culture of the Moors by creating traditional foods including tagines, flatbreads, harrisa, cous cous and of course, something sweet. Lunch is included in the class and will be a tasting of the dishes prepared.
Sample Recipes: Carrots in Chermoula/Squash and Lentil Tagine/Seven Vegetable Cous Cous/Stuffed Flatbread/Harissa/Moroccan Macaroons
Cost £65. Contact 01285 640441 or email firstname.lastname@example.com
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Most Back Christian Photogs' Right to Refuse Gays
Most Back Christian Photogs' Right to Refuse Gays
352 results for 'religious freedoms'. Showing results 163 - 180
Most Back Christian Photogs' Right to Refuse Gays
Faith Community Braces for Impact of Gay Rulings
Syrian Christians: 'Why Is America at War with Us'
Secret Believers Share Faith under Fire
CBN News gained exclusive access to a gathering of secret believers inside a former Soviet Republic to get a...
One hundred thousand Christians are murdered because of their faith each year. In many cases, governments are to blame...
Religious Freedom Ambassador
This week on the Brody File: Former Republican Congressman JC Watts joins The Brody File in studio this week...
Artist Says Pentagon Censoring Christian Art
IRS, Obamacare 'Unprecedented' Threat to Liberty
Christian, Jewish Persecution Up in Muslim Nations
ACLJ: 'Extremist' Worst Candidate to Advise Pentagon
On Newswatch, May 9: Boston's top cop kept in dark on FBI bomber probe, Texas cheerleaders score win for...
Texas Cheerleaders Score Win for Religious Freedom
Extremism Blamed for Religious Minority Persecution
Pentagon: Proselytizing Punishable by Court-Martial
Christians Worldwide to Gather to Pray for Burma
Miss. House Bill Would Allow School Prayer


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From restaurant and movie chains to colleges and local governments, employers are beginning to trim hours. According to a study from UC Berkeley, some 2.3 million workers across the country are at risk of having their hours cut back thanks to Obamacare.
Even as the White House dismisses story after story as "anecdotal," its allies are are insisting the impact is real. Joseph Hansen, president of the 1.2 million member United Food and Commercial Workers union, told NBC, "Wait a year. You'll see tremendous impact as workers have their hours reduced and their incomes reduced. The facts are already starting to show up. Their statistics, I think, are a little behind the time."
As with most big-government interventions, the impact will be felt most acutely on those without the means to overcome a new set of economic barriers. Obamacare is hurting low-skilled workers, explains the Heritage Foundation, because "it raises the minimum productivity required for them to hold a full-time job, particularly workers with families. … Employers will not hire them at a loss."
The sad irony is that labor unions were a driving force behind the law's eventual passage in 2010 and many claimed it would help lift low-skilled workers up. Now, as those low-skilled workers are being pinched by a painfully slow economic recovery and Obamacare, labor leaders are secretly begging the White House to fix the law.
Unfortunately, there is no quick fix for Obamacare. As implementation continues to ramp up, the law's impact will ripple across the country, hurting those who are most vulnerable. The only way to stop the avalanche of "unintended consequences" is to stop Obamacare.
Rush Limbaugh defends Rubio's debate answer: He's absolutely right that Obama knows what he's doing | Allahpundit
Time for Team Hillary to break out the gender card for young liberal women who prefer Sanders | Allahpundit


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|MJHS Winter Guard, Drum Line need donations to get to World Championships
|Thursday, April 4, 2013
The Mt. Juliet High School Winter Guard and Drum Line are needing money to compete in the World Championships in Dayton, Ohio next week.
The MJHS Winter Guard will travel to the Winter Guard International World Championships April 10-14 in Dayton. The Mt. Juliet winter guard is currently ranked eighth of 120 groups participating in championships. They are trying to raise about $5,000 to fund their trip.
The guard has had a fantastic season and will compete for the state championships over the weekend at Belmont University. The guard is made up of 20 students from Mt. Juliet High School and Mt. Juliet Middle School.
The MJHS Winter Drum Line will also travel to Dayton for the percussion world championships April 17-20. The MJHS percussionists have had a fantastic season and they will go to Dayton with the fifth highest score posted this season. The winter drum line is made up of 39 students from the high school and middle school. They also will compete at the state tournament this weekend at Belmont. They are trying to raise about $10,000 to go Dayton.


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omg !!
This is a phenomenal and attention grabbing design. If I had the money and this were real, I'd have it.
won-der-ful XD
I like this!
astonishing!!! awesome design and render
Excellent Work .....!
That is one awesome design!
That's... EPIC
I love polygonal (or similar) designs
I love polygonal (or similar) designs
damn hot the only thing you need to change are the wheels. 5 spoke rims would looking much better on that awesome concept the 3 or 4 spokerims. much more dynamic.....
What program?


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Purchase auto parts from our website Sunday through Saturday. Online purchasing of Toyota Corolla Head Light auto parts is the future of fixing your vehicle. No matter how much an order weighs, we will ship any order of Toyota Corolla Head Light parts to the 48 states at no cost to you. There is absolutely no bad time to order Toyota Corolla Head Light parts from our website. Our website allows you to fit your auto parts shopping in any time. We take pride in offering the best customer service of any online auto parts store. Place your next Toyota Corolla Head Light parts order with us. Our staff is waiting to hear from you via email.
Barbara H. - Tacoma, WA: Thanks for foglight. Great price and lightning fast delivery.


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The famous studio is expanding
Pinewood Studios – the famous home of Britain's James Bond – is expanding from the leafy London suburb of Shepperton to the bright, expansive lands south of Atlanta in Fayette County, Georgia. Pinewood Atlanta will provide world-class studio facilities for the production of film, television, music and video games.
Ivan Dunleavy, Pinewood CEO, said: "Today's agreement is another step forward for the Pinewood brand internationally. This new studio will target US productions. Georgia has excellent fiscal incentives and a great crew base. With River's Rock we have a well resourced partner that is committed to building a first class studio facility." Georgia is fast becoming a hot spot for film production due to tax breaks that have recently emerged. The state provides a 20% tax credit for companies that spend $500,000 or more on a production; what's more, film producers also can receive an additional 10% if the project helps promote the state of Georgia. We're not sure how The Walking Dead – also filmed and set in Georgia – promotes the state, but that's just one of the successful shows flourishing in Empire State of the South.
James Bond was filmed at Pinewood - but they didn't use waxy people
Jim Pace, Managing Partner, River's Rock llc said: "We are tremendously excited to be creating a world class studio in the state of Georgia and are looking forward to working with Pinewood in the many years to come. The Pinewood brand is so well recognized in the global film industry and together there is a great opportunity to build an excellent facility that will attract the very best producers."


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Diana at 50?


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somewhat helpful
2 people found the following review helpful
Posted by Reviewer1301163 on Jul 24, 2012
I take lutein and zeaxanthin regularly, but sometimes my eyes just feel weak and irritated, so I take these too on those days. They were on sale at a good price, and have some herbs my other supplements don't have. I'm not really sure if I'd get them when they're not on sale. They do help a little, but not much.
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Article | January 31, 2001
Georgia-Pacific Corp.: Georgia-Pacific Corp.: Georgia-Pacific Corp.: Returnable containers
IPL Products (St. Damien, Quebec, Canada) has developed PP returnable produce containers featuring radio frequency identification. Developed in conjunction with Georgia-Pacific (Norcross, GA), containers comply with the New Modularity Standard issued by the Fibre Box Assn.
Can be inter-stacked with FBA-compliant corrugated boxes. Available in 23.62"x15.75" footprint.
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I just heard on the Sunday Night pregame show that Larry Fitzgerald is not long for the Cardinals,would you give up the 2011 #1 pick for a proven pro bowl receiver or draft one and wait for him to learn ?
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I just heard on the Sunday Night pregame show that Larry Fitzgerald is not long for the Cardinals,would you give up the 2011 #1 pick for a proven pro bowl receiver or draft one and wait for him to learn ?
Fitzgerald is a fairly young 27 and there is a chance that neither Green nor Jones will be available when the Rams are picking 1st.
I'd make that trade.
Heck yes, and I'm sure any team needing a WR would trade their #1 for Fitz as well, BUT they'll never trade him to a division rival for the going rate, if at all. They'd want that #1, plus another pick probably to go to the niners, hawks or us.
Depends on what picks/players we have to give up. If we have to trade in more than our 1st round pick. Then I'll stick with drafting a #1 WR or a 2nd round pick for Sidney Rice because his injuries should devalue him.
It depends on how high we end up picking. I have a feeling that we won't be able to get him with the 32nd overall pick alone ;)
In all seriousness, I think that we'd be lucky to get our hands on him, but I think the coaching staff will want to draft their own player. If we can get him for something like a late first, or a second and a player, or a 2012 selection, I'd say go for it.
Not just proven talent but proven elite talent if you ask me + the fact we won't pick high enough for Green = an almost no brainier.
I say almost because I would want to make sure a long term deal could be worked out first. Fitzgerald has only 2 years left on his contract and I wouldn't want to burn a 1st rounder just to end up back in need in 2 years.
All that said I seriously doubt the Cardinals would trade him inside the division if they trade him at all.
They'll want a Herschel Walker trade type scenario if we want to make negotiations. Though I'd like have revenge against the Cards for torching us with Kurt Warner, Fitz does seem like the leader of the Cards and for him to just want to leave seems like he's showing signs that LeBron James attitude. I mean Steven Jackson has went through 3 disappointing seasons yet he's more driven to see this team just have a winning season rather than break rushing records. Even though I view Fitz as a demon in our division, he should at least try learning a thing or two about leadership from Jackson because compared to what Jackson went through, Fitz will deal with less troubles.
BTW can you find an article for me about this report on him?
Fitzgerald doesn't seem the same after his injuries, earlier this year! Make sure to kick the tires before settling for damaged goods!
Does anyone really think Arizona would trade him within the division?
He's missed 4 games in his entire 7 year career. I wish our players could be that "injury prone".Quote:
Originally Posted by Peoria


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Malta - 2 euros 2015 (Proclamation of the Republic of Malta in 1974)
Belgium - 2 euros 2015 (30th anniversary of the EU flag)
Greece - 2 euros 2015 (75 Years since the Death of Spyridon Louis)
Luxembourg - 2 euros 2015 (30th anniversary of the EU flag)
Greece - 2 euros 2015 (30th anniversary of the EU flag)
The following 2 euro commemortaive coins were issued in italy since the introduction of the Common
European Currency on January 1, 2002.
In July 2015, the 19 euro-area countries jointly issued a commemorative euro coin celebrating 30 years of the EU flag. Regardless of the country, it bears the same design on the national side, normally reserved for a motif specific to that country. This ... [ More ]
The second Italian commemorative coin for 2015 marks the 750th anniversary of the birth of Dante Alighieri. Durante degli Alighieri, simply called Dante, was a major Italian poet of the late Middle Ages. His Divine Comedy, originally called Comedìa (modern ... [ More ]
Expo 2015 is the next scheduled Universal Exposition after Expo 2012, hosted by Milan, Italy, between 1 May and 31 October 2015. It is the second time Milan hosts the exposition, the first being the Milan International of 1906. Expo 2015 is held under ... [ More ]
The Carabinieri is the national military police of Italy, policing both military and civilian populations (1814 - 2014). It was originally founded as the police force of the Kingdom of Sardinia. During the process of Italian unification, it was appointed ... [ More ]
Galileo Galilei was born in Pisa, Italy on February 15, 1564. He was the oldest of seven children. His father was a musician and wool trader, who wanted his son to study medicine as there was more money in medicine. His achievements include improvements ... [ More ]
Giuseppe Fortunino Francesco Verdi (10 October 1813 – 27 January 1901) was an Italian Romantic composer, mainly of opera. Some of his themes have long since taken root in popular culture – such as "La donna e mobile" from Rigoletto, "Va, pensiero" (The ... [ More ]
Giovanni Boccaccio (1313 – 21 December 1375) was an Italian author and poet, a friend, student, and correspondent of Petrarch, an important Renaissance humanist and the author of a number of notable works including the Decameron, On Famous Women, and ... [ More ]
Giovanni Placido Agostino Pascoli was an Italian poet and classical scholar. He was born at San Mauro di Romagna (in his honor renamed "San Mauro Pascoli" in 1932), into a well-to-do family. He was the fourth of ten children of Ruggero Pascoli and Caterina ... [ More ]
On 1 January 2002, euro banknotes and coins were introduced in 12 Member States of the European Union. The introduction of the euro cash was
an unprecedented challenge, but it went smoothly, and billions of banknotes and coins started to circulate in ... [ More ]
Italian unification was the political and social movement that agglomerated different states of the Italian peninsula into the single state of Italy in the 19th century. Despite a lack of consensus on the exact dates for the beginning and end of this ... [ More ]
Camillo Paolo Filippo Giulio Benso, Count of Cavour, of Isolabella and of Leri was a leading figure in the movement toward Italian unification. He was the founder of the original Italian Liberal Party and Prime Minister of the Kingdom of Piedmont-Sardinia. ... [ More ]
The Braille system is a method that is widely used by blind people to read and write. Braille was devised in 1821 by Louis Braille, a blind Frenchman. Each Braille character or cell is made up of six dot positions, arranged in a rectangle containing two ... [ More ]
A first attempt to create an economic and monetary union between the members of the European Communities goes back to an initiative by the European Commission in 1969. However, the introduction of the euro started principally on 31 December 1998, when ... [ More ]
On 10 December 2007, Human Rights Day, the Secretary-General and High Commissioner for Human Rights launched a year-long celebration of the 60th anniversary of the Universal Declaration of Human Rights. A man and a woman with an olive branch, an ear ... [ More ]
The Treaty of Rome established the European Economic Community and ultimately led to the introduction of the euro in 1999 and the euro banknotes and coins in 2002. The anniversary was celebrated on 25 March 2007 and the euro area countries have marked ... [ More ]
An image of a skier, a dynamic, curvilinear figure, is in the centre of the coin. Above him are the words 'GIOCHI INVERNALI' and to his left the location of the Winter Games is marked by the word 'TORINO' and an image of Turin's landmark Mole Antonelliana ... [ More ]
The centre of the coin features Europa and the bull, with Europa holding a pen and the text of the European Constitution. To the upper left of the image is the mintmark 'R'. The initials of engraver Maria Carmela Colaneri, 'MCC', appear on the lower left ... [ More ]
The foreground shows the globe, tilted to the right and bearing the inscription WORLD FOOD PROGRAMME, from which emerges an ear of wheat, an ear of maize and an ear of rice, the three grains representing the world's basic sources of nourishment. To the ... [ More ]


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Supporters of the new Planned Parenthood facility are expected to gather at the groundbreaking of the facility Wednesday.
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Evan James Moore (twitter: @evanmoore89)
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Height: 6-7 Weight: 232 lbs.
Born: January 3, 1985 in Brea, CA
High School: Brea-Olinda
College: Stanford (school history) (Moore college stats)
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When a murder investigation leads the team to Gibbs' hometown, secrets about his past are revealed.
A distinguished senator asks Gibbs for help in solving the murder of a young female Naval officer.
Gibbs' hunt for the killer of a marine puts him on a collision course with an old friend.
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Clemastine Fumarate Tablets
FDA Approves Oralair for Grass Allergies »
"The U.S. Food and Drug Administration recently approved Oralair to treat allergic rhinitis (hay fever) with or without conjunctivitis (eye inflammation) that is induced by certain grass pollens in people ages 10 through 65 years. Oralair is the f"...
Clemastine Fumarate Tablets
Antihistamines should be used with considerable caution in patients with: narrow angle glaucoma, stenosing peptic ulcer, pyloroduo-denal obstruction, symptomatic prostatic hypertrophy, and bladder neck obstruction.
Use in Children: Safety and efficacy of clemastine fumarate have not been established in children under the age of 12 years.
Use in Pregnancy: Experience with this drug in pregnant women is inadequate to determine whether there exists a potential for harm to the developing fetus.
Use with CNS Depressants: Clemastine has additive effects with alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers, etc.)
Use in Activities Requiring Mental Alertness: Patients should be warned about engaging in activities requiring mental alertness such as driving a car or operating appliances, machinery, etc.
Use in the Elderly (approximately 60 years or older): Antihistamines are more likely to cause dizziness, sedation, and hypotension in elderly patients.
General: Clemastine fumarate should be used with caution in patients with: history of bronchial asthma, increased intraocular pressure, hyperthyroidism, cardiovascular disease, and hypertension.This monograph has been modified to include the generic and brand name in many instances.
Last reviewed on RxList: 8/11/2008
Clemastine Fumarate Tablets FDA Prescribing Information
Additional Clemastine Fumarate Tablets Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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By JOSH LEDERMAN Associated Press
WASHINGTON (AP) – The White House says President Barack Obama will meet Friday with congressional leaders to discuss what to do about $85 billion in mandatory spending cuts.
The top Democrat and Republican in both the House and Senate will attend. It's the first face-to-face meeting between Obama and Republican leaders this year.
Senate Republican Leader Mitch McConnell says it's a chance to address ways to reduce government spending. He says Americans won't accept more taxes as part of a deal to avert the cuts.
The across-the-board cuts are set to kick in on Friday, so the meeting will come after Congress has officially missed the deadline for averting the cuts.
(Copyright 2013 by The Associated Press. All Rights Reserved.)
A look at winter weather news from around the D.C. area.
From Rhett & Scarlett to Harry & Sally, who are the most romantic movie couples?


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About StumbleDNA StumbleDNA
Warning: Looking At This Will Make You Wake Up At 6AM Everyday!...
Dear blank, please blank: Hilarious.
All of the most hilarious letters on dearblankpleaseblank.com.
13 GIFs of Perfectly Timed TV Graphics
Sometimes you meet someone, and it's so clear that the two...
The 12 Most Strangely Satisfying Videos on the Internet
Why Do Guys... Text Their Feelings
17 Ways To Never Have A Bad Hair Day Again
From no-heat waves to sticky bobby pins, these easy hair hacks will banish subpar styles from your life.
The Top 75 'Pictures of the Day' for 2012
After the positive reception from last year's "Top 50 'Pictures of the Day' for 2011", the Sifter promised to highlight the top 25 'Pictures of the Day...
Kittens And Puppies Discovering The Mirror
Cat Hugs Baby Kitten Having Nightmare
WATCH AND LIKE MY NEW CHRISTMAS VIDEO!!!! http://www.youtube.com/watch?v=w6VpjvrW5a8 Kitten is having night mare. Cat comforts it. This is sickeningly adorable!
Young girl who's best friends with African wildlife
Things You Didn't Know About Cartoon Logic
Only in Japan ~ Pink Tentacle
For interesting photos of scenes unique to Japan, do a search for "only in Japan" on Google Image Search. Here's a sampling of what you'll find on the top few pages...
The top 8 idiots in the country.
Jokes, pictures, funny sayings, humor, email, funny mpg
12 More Instances of Bill Murray Being Awesome with Fans...
And the legend of Bill Murray continues. Photos have recently popped up of Murray crashing a kickball game, the most recent in the many tales of spontaneous Bill Murray sightings.
5 Popular Zombie Survival Tactics (That Will Get You Killed)...
You've got the exact same essential plan as everybody else: go raid the gun store, get out of the cities as fast as possible, find a sturdy base to fortify and hole up in, use a melee weapon whenever possible to conserve ammo and--if the worst does c...
Old Spice Voicemail Generator
Hello, you have dialed (just put your number, no dashes) The tall, accomplished you're calling can't come to the phone right now because they're on Reddit. Ripping out mass loads of weights. Polishing their monocle smile. Cracking walnuts...
8 Fairy Tales And Their Not-So-Happy Endings
21 Incredibly Close Calls
This Is Not The Gift She Wanted
Jimmy Kimmel issued another one of his popular YouTube challenges in honor of Valentine's Day last week, this time requesting viewers send him videos entitled, "Hey Jimmy, I Gave My Wife Or Girlfriend A Terrible Gift." Judging by most of these, he al...
Worst Beauty Trends - YouBeauty.com
See which hair and makeup trends over the years were the best of the worst.
Nedroid Picture Diary
Nedroid Picture Diary
Nedroid Picture Diary
Hello! Please enjoy these drawings and comics.
I'm eating this, not that
Easy Casserole : recipes and cooking : Food Network
10 Food Frauds - YouBeauty.com
Why You Can't Stand Certain Foods - YouBeauty.com
Do you find cilantro sickening? Or eggplant icky? You're not alone. We take a look at the most popular polarizing foods.
Your (additional) Rules of the Internet
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Are you Craig A Parish?Claim your profile
Publications (13)66.48 Total impact
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ABSTRACT: The Candida albicans fitness test is a whole cell screening platform that utilizes a mixed-pool of C. albicans mutants, each of which carries a heterozygous deletion of a particular gene. In the presence of an antifungal inhibitor, a subset of these mutants exhibits a growth phenotype of hypersensitivity or hyposensitivity. Collectively these mutants reflect aspects of the mechanism of action of the compound in question. In the course of screening natural products a culture of Streptomyces sp. MS-1-4 was discovered to produce a compound, dretamycin, which yielded a fitness profile exhibiting significant hypersensitivity of the DRE2 heterozygote and hyposensitivity of the DIP5 heterozygote. Herein we report the production, isolation, and structure elucidation of dretamycin.
Article: Improving the In Vivo Therapeutic Index of siRNA Polymer Conjugates through Increasing pH Responsiveness[Show abstract] [Hide abstract]
ABSTRACT: Polymer based carriers that aid in endosomal escape have proven to be efficacious siRNA delivery agents in vitro and in vivo; however, most suffer from cytotoxicity due in part to a lack of selectivity for endosomal versus cell membrane lysis. For polymer based carriers to move beyond the laboratory and into the clinic, it is critical to find carriers that are not only efficacious, but also have margins that are clinically relevant. In this paper we report three distinct categories of polymer conjugates that improve the selectivity of endosomal membrane lysis by relying on the change in pH associated with endosomal trafficking, including incorporation of low pKa heterocycles, acid cleavable amino side chains, or carboxylic acid pH sensitive charge switches. Additionally, we determine the therapeutic index of our polymer conjugates in vivo and demonstrate that the incorporation of pH responsive elements dramatically expands the therapeutic index to 10-15, beyond that of the therapeutic index (less than 3), for polymer conjugates previously reported.
- [Show abstract] [Hide abstract]
ABSTRACT: With the development of new synthesis procedures, an ever increasing number of chemical modifications can now be incorporated into synthetic oligonucleotides, representing new challenges for analytical chemists to efficiently identify and characterize such molecules. While conventional mass spectrometry (MS) has proven to be a powerful tool to study nucleic acids, new and improved methods and software are now needed to address this emerging challenge. In this report, we describe a simple yet powerful program that affords great flexibility in the calculation of theoretical masses for conventional as well as modified oligonucleotide molecules. This easy to use program can accept input oligonucleotide sequences and then calculate the theoretical mass values for full length products, process impurities, potential metabolites, and gas phase fragments. We intentionally designed this software so that modified nucleotide residues can be incorporated into oligonucleotide sequences, and corresponding mass values can be rapidly calculated. To test the utility of this program, two oligonucleotides that contain a large number of chemical modifications were synthesized. We have analyzed these samples using a Q-TOF mass spectrometer and compared the calculated masses to the observed ones. We found that all of the data matched very well with less than 30 ppm mass errors, well within the expectation for our instrument operated in its current mode. These data confirmed the validity of calculations performed with this new software. Figure
Article: Broadening the Spectrum of -Lactam Antibiotics through Inhibition of Signal Peptidase Type I[Show abstract] [Hide abstract]
ABSTRACT: The resistance of methicillin-resistant Staphylococcus aureus (MRSA) to all β-lactam classes limits treatment options for serious infections involving this organism. Our goal is to discover new agents that restore the activity of β-lactams against MRSA, an approach that has led to the discovery of two classes of natural product antibiotics, a cyclic depsipeptide (krisynomycin) and a lipoglycopeptide (actinocarbasin), which potentiate the activity of imipenem against MRSA strain COL. We report here that these imipenem synergists are inhibitors of the bacterial type I signal peptidase SpsB, a serine protease that is required for the secretion of proteins that are exported through the Sec and Tat systems. A synthetic derivative of actinocarbasin, M131, synergized with imipenem both in vitro and in vivo with potent efficacy. The in vitro activity of M131 extends to clinical isolates of MRSA but not to a methicillin-sensitive strain. Synergy is restricted to β-lactam antibiotics and is not observed with other antibiotic classes. We propose that the SpsB inhibitors synergize with β-lactams by preventing the signal peptidase-mediated secretion of proteins required for β-lactam resistance. Combinations of SpsB inhibitors and β-lactams may expand the utility of these widely prescribed antibiotics to treat MRSA infections, analogous to β-lactamase inhibitors which restored the utility of this antibiotic class for the treatment of resistant Gram-negative infections.
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ABSTRACT: Starting with the discovery of penicillin, the pharmaceutical industry has relied extensively on natural products (NPs) as an unparalleled source of bioactive small molecules suitable for antibiotic development. However, the discovery of structurally novel and chemically tractable NPs with suitable pharmacological properties as antibiotic leads has waned in recent decades. Today, the repetitive "rediscovery" of previously known NP classes with limited antibiotic lead potential dominates most industrial efforts. This limited productivity, exacerbated by the significant financial and resource requirements of such activities, has led to a broad de-emphasis of NP research by most pharmaceutical companies, including most recently Merck. Here we review our strategies--both technological and philosophical--in addressing current antifungal discovery bottlenecks in target identification and validation and how such efforts may improve NP-based antimicrobial discoveries when aligned with NP screening and dereplication.
Article: ChemInform Abstract: Isolation and Structure Elucidation of Parnafungins C and D, Isoxazolidinone-Containing Antifungal Natural Products[Show abstract] [Hide abstract]
ABSTRACT: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option.
Article: Discovery of the parnafungins, antifungal metabolites that inhibit mRNA polyadenylation, from the Fusarium larvarum complex and other Hypocrealean fungi[Show abstract] [Hide abstract]
ABSTRACT: Evaluation of fungal fermentation extracts with whole cell Candida albicans activity resulted in the identification of a novel class of isoxazolidinone-containing metabolites named parnafungins. Chemical-genetic profiling with the C. albicans fitness test identified the biochemical target as inhibition of polyadenosine polymerase, a component of the mRNA cleavage and polyadenylation complex. Parnafungins were discovered from fermentation extracts of fungi resembling F. larvarum isolated from plants, plant litter and lichens. Furthermore authentic strains of F. larvarum var. larvarum and F. larvarum var. rubrum could be induced to produce parnafungins and their degradation products in low titers. Relationships among strains of the F. larvarum complex (FLC), including parnafungin-producing strains, were examined by cladistic analyses of rDNA, mitochondrial rDNA, and two protein-coding genes, comparisons of antifungal activity and antifungal metabolite profiles, and morphological phenotypes. Integrated analyses of these data led to the conclusion that the diversity within the FLC exceeded the one-to-one correspondence between F. larvarum and its teleomorph Cosmospora aurantiicola. Based on multiple gene sequence analyses, strains of the FLC formed a monophyletic clade inclusive of the parnafungin-producing strains. The FLC, including newly discovered parnafungin-producing strains, could be resolved into at least six different lineages, possibly representing cryptic' species, of which one was not fully resolved from F. larvarum var. rubrum. Fusarium larvarum var. rubrum represents a species distinct from var. larvarum. Finally we report that two other species from the Hypocreales, Trichonectria rectipila and Cladobotryum pinarense, are able to produce parnafungins and their open-ring forms.
Article: ChemInform Abstract: Isolation and Structure Elucidation of Parnafungins C and D, Isoxazolidinone-Containing Antifungal Natural Products[Show abstract] [Hide abstract]
ABSTRACT: Parnafungins, natural products containing an isoxazolidinone ring, have been isolated from Fusarium larvarum and have been shown to be potent inhibitors of the fungal polyadenosine polymerase. The extraction and analysis of fermentation broths of taxonomically related organisms identified as closely related Fusarium spp. produce not only parnafungin A and B, but also significant quantities of two related components. These members of the paranfungin family of natural products have been isolated and the structure of each has been elucidated. While structurally analogous to parnafungin A, parnafungin C is further elaborated by methylation of a phenolic hydroxyl group, and parnafungin D has both the methyl phenol ether as well as an epoxide in the xanthone ring system. Parnafungin C and D have potent, broad spectrum antifungal activity and also have been shown to target fungal mRNA cleavage and polyadenylation.
Article: Antisense-Guided Isolation and Structure Elucidation of Pannomycin, a Substituted cis-Decalin from Geomyces pannorum[Show abstract] [Hide abstract]
ABSTRACT: Antisense-based screening strategies can be used to sensitize a microorganism and selectively detect inhibitors against a particular cellular target of interest. A strain of Staphylococcus aureus that generates an antisense RNA against SecA,a central member of the protein secretion machinery, has been used to screen for novel antibacterials. Possible inhibitors of the SecA ATP-ase were selected with a high-throughput, two-plate agar-based whole cell differential sensitivity screen. After screening a library of over 115 000 natural products extracts with the SecA antisense strain, an extract of Geomyces pannorum was identified as providing increased activity against the sensitized strain as compared with the wild-type control. Bioassay-guided isolation of the active component from this fungal extract provided a new cis-decalin secondary metabolite, which we have named pannomycin.
Article: Application of Affinity Selection/Mass Spectrometry to Determine the Structural Isomer of Parnafungins Responsible for Binding Polyadenosine Polymerase[Show abstract] [Hide abstract]
ABSTRACT: To discover antifungal treatments that possess the desired characteristics of broad spectrum activity, a strong safety profile, and oral bioavailability, new discovery strategies must be implemented to identify structural classes of molecules capable of combating these microorganisms. One such technique that has been implemented is the Candida albicans Fitness Test, a whole cell screening platform capable of delineating the mechanism of action of compounds that demonstrate activity against the clinically relevant pathogenic fungus, C. albicans. Screening crude natural product extracts with this technology has resulted in the identification of a novel family of antifungal natural products, named the parnafungins, which inhibit the enzyme polyadenosine polymerase (PAP), a key component of the mRNA cleavage and polyadenylation complex. Owing to the rapid interconversion of the structural and stereoisomers of the parnafungins at neutral pH, the determination of the structural isomer with the highest affinity for PAP with standard biochemical assays has not been possible. Herein, we present an application of affinity-selection/mass spectrometry (AS-MS) to determine that the "straight" parnafungin structural isomer (parnafungin A) binds preferentially to PAP compared to the "bent" structural isomer (parnafungin B).
Article: Isolation and Structure Elucidation of Parnafungins, Antifungal Natural Products that Inhibit mRNA Polyadenylation[Show abstract] [Hide abstract]
ABSTRACT: The Candida albicans Fitness Test, a whole-cell screening platform, was used to profile crude fermentation extracts for novel antifungal natural products with interesting mechanisms of action. An extract with intrinsic antifungal activity from the fungus Fusarium larvarum displayed a Fitness Test profile that strongly implicated mRNA processing as the molecular target responsible for inhibition of fungal growth. Isolation of the active components from this sample identified a novel class of isoxazolidinone-containing natural products, which we have named parnafungins. These natural products were isolated as an interconverting mixture of four structural- and stereoisomers. The isomerization of the parnafungins was due to a retro-Michael ring-opening and subsequent reformation of a xanthone ring system. This interconversion was blocked by methylation of an enol moiety. Structure elucidation of purified parnafungin derivatives was accomplished by X-ray crystallography and NMR analysis. The biochemical target of these natural products has been identified as the fungal polyadenosine polymerase. Parnafungins demonstrated broad spectrum antifungal activity with no observed activity against gram-positive or gram-negative bacteria. The intact isoxazolidinone ring was required for antifungal activity. In addition, the natural products were efficacious in a mouse model of disseminated candidiasis.
Article: PAP Inhibitor with In Vivo Efficacy Identified by Candida albicans Genetic Profiling of Natural Products[Show abstract] [Hide abstract]
ABSTRACT: Natural products provide an unparalleled source of chemical scaffolds with diverse biological activities and have profoundly impacted antimicrobial drug discovery. To further explore the full potential of their chemical diversity, we survey natural products for antifungal, target-specific inhibitors by using a chemical-genetic approach adapted to the human fungal pathogen Candida albicans and demonstrate that natural-product fermentation extracts can be mechanistically annotated according to heterozygote strain responses. Applying this approach, we report the discovery and characterization of a natural product, parnafungin, which we demonstrate, by both biochemical and genetic means, to inhibit poly(A) polymerase. Parnafungin displays potent and broad spectrum activity against diverse, clinically relevant fungal pathogens and reduces fungal burden in a murine model of disseminated candidiasis. Thus, mechanism-of-action determination of crude fermentation extracts by chemical-genetic profiling brings a powerful strategy to natural-product-based drug discovery.
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ABSTRACT: The isolation and structure elucidation of 1 from the Basidomycete fungus Baeospora myosura is described. This new ene-triyne antibiotic was most potent against Gram-positive bacteria, while it was less active against Gram-negative bacteria and a yeast. MICs against several strains of Staphylococcus aureus were as low as 0.001 microg/mL. Analogues of 1 that did not contain the ene-triyne moiety were inactive against all microorganisms tested. The isolation of this new natural product was complicated by the highly reactive nature of the conjugated terminal polyacetylene.


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CenturionFinal by VegasMikeWatch
©2013-2016 VegasMike
We landed on Planet17X and discovered a new race of alien warriors, the Skayth. Negotiations for peace were short lived...The Leader of the legion let forth a blast of plasma from within his very arm! The results were devastating...our soldiers were completely annihilated. The species appears to have the ability to generate plasma like a spider creates silk. This biological matter is then electrically charged as it emits from the arm chamber. The largest Centurion versions have the ability to shoot in a continuous stream whereas the grunts shoot in charged blasts or pulse attacks.
Looks like a concept art for a movie I would like to see!!!
I meant to fav this months ago....shows how busy I've been.
I love the lighting, brings a lot of power coming from the dark.
Nice, I would hate to be on the receiving end of that attack.
I am blown away by your art work.i had no idea of the scope of your talent. I could not even imagine how you could create such intricate and imaginative work. What medium,media? Average size?
Unbelievable. Adam. I am impressed. Thank you for sharing.George
Unbelievable. Adam. I am impressed. Thank you for sharing.George
EEEEEK! *runs away shrieking*
Pew Pew!!
There goes the planet!


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Barack Obama channeled Teddy Roosevelt this week in a speech in Osawatomie, Kan. Supporters are calling it the most significant economic speech of his administration.
But critics rightly point out that the Teddy Roosevelt whom Obama invoked was not the beloved 26th president and standard-bearer of the GOP. Instead, it was the radicalized third-party candidate seeking a third term and the man whose progressivism was a precursor to the rise of big government in the later 20th century. What's more, President Obama's speech was so full of reckless accusations and misinformation that The Washington Post's Fact Checker blog gave it three Pinocchios, signifying "significant factual errors."
President Obama has a history of comparing himself to American giants -- from Abraham Lincoln to Ronald Reagan. So it's no surprise that he would choose to give his speech in the same town as Teddy Roosevelt's 1910 address. But whenever Obama invokes past heroes, he ends up looking smaller. And this week's speech was a prime example.
Roosevelt at least acknowledged that he was launching a radical platform; whatever one might think about the progressivism he was trying to usher in, Roosevelt was man enough to admit that what he was proposing was a huge departure from the past. Obama, on the other hand, tried to cloak much of what he said in soothing rhetoric, invoking his grandparents' Kansas roots and depicting a long-lost time when "hard work paid off, responsibility was rewarded, and anyone could make it if they tried -- no matter who you were, where you came from or how you started out."
This president seems to think that period in American history is now gone -- and he blames corporations and the rich for destroying it. But he pulled his punches in the speech, never quite owning up to the implications of what he was saying.
For example, when Obama claimed that "huge advances in technology have allowed businesses to do more with less and made it easier for them to set up shop and hire workers anywhere in the world," he never quite had the nerve to describe how he would solve the problem. Teddy Roosevelt thought big corporations were the enemy of the common man and proposed a Bureau of Corporations to control their power. Would Obama like to prevent companies from shipping jobs overseas? No doubt he would -- but he won't say it directly.
Doing so might risk his ability to raise political contributions from donors whose wealth comes from profits made because cheaper labor is available offshore. And it might offend many middle-class, even poor, people who realize that their lives are better because they have access to cheaper goods made in China, Thailand, Mexico and elsewhere -- goods they couldn't afford if American workers were producing them.
So instead of launching into a radical critique of American capitalism, the president hints around the edges. He plays class warfare, even while he protests that he isn't. Instead of embracing redistribution of wealth directly, he creates straw men, as he did over and over again in the speech.
He claimed that it's unfair for construction workers, teachers, and nurses earning $50,000 a year "to pay a higher tax rate than somebody pulling in $50 million," and that a "quarter of all millionaires now pay lower tax rates than millions of middle-class households." He even said that "some billionaires have a tax rate as low as 1 percent."
But as The Washington Post pointed out, of the top 400 wealthiest individuals in the U.S. in 2008 (the last year for which such data is available), most paid in excess of 35 percent in taxes and "only 17 had a marginal rate of zero to 26 percent." Even the Post acknowledged that for this handful of individuals, there might well be reasonable explanations why they paid so little, including that they earned little or nothing that year.
If Barack Obama were really another Teddy Roosevelt, he'd take his chances and say what he means. If he wants to redistribute wealth and tell corporations how much profit they can earn and how many workers they must hire, let him take his case to the American people.
Linda Chavez is chairman of the Center for Equal Opportunity and author of Betrayal: How Union Bosses Shake Down Their Members and Corrupt American Politics .
Be the first to read Linda Chavez's column. Sign up today and receive Townhall.com delivered each morning to your inbox.
Rush Limbaugh defends Rubio's debate answer: He's absolutely right that Obama knows what he's doing | Allahpundit
Time for Team Hillary to break out the gender card for young liberal women who prefer Sanders | Allahpundit


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Remember that Walden's Title IV Code is 025042.
Public health graduate Khin Mar '11 offers support to victims and shows others how to help.
Want to retain your top talent? Award-winning PhD in Management student Lisa Haneberg explains how to start by asking the right questions.
The Honorary Chancellor of Laureate International Universities addresses recent Walden University graduates.
Dr. Michael Eric Dyson explains why "failing" as a church pastor inspired him to build his own path to a PhD—and become a social activist.
Two Walden faculty members weigh in on their time in Qatar.
Walden University student Hollis Easter describes how his MS in Instructional Design and Technology program helped him save business-sustaining funds at a nonprofit crisis intervention hotline.
Psychotherapy patients with hearing impairments aren't improving as well as their counterparts. Dr. Amy Storch '10, PhD in Psychology, is on a mission to change that.
The 2010 presidential fellowship recipients share how they hope their research will effect positive social change.
Or call 1-866-492-5336 to speak to an advisor
© 2016 Walden University


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Picture: Lena Dunham - TIME 100 Gala TIME'S 100 Most Influential People In The World at Jazz at Lincoln Center- Inside Arrivals - New York City,...
Actress Lena Dunham is set to be honoured by America's Planned Parenthood group for exploring the issues facing modern women in her Tv show Girls.
Dunham, the creator and star of Girls, will receive the Maggie Award for Media Excellence for promoting frank conversation about sexuality through the series, which centres around four young women living in New York City.
She will be handed the honour at the annual Planned Parenthood dinner in Washington, D.C. on Thursday (25Apr13) and U.S. President Barack Obama will deliver the keynote address.
The organisation provides sexual and reproductive health services to women across the U.S.


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Harry and Debbie plan a family bowling night, disrupting Annie and Dixon's Friday night plans; Naomi has a disappointing evening with her father; Dixon finds Silver asleep in her car, prompting Kelly (Jennie Garth) to confront their mother, Jackie.
Brenda (Shannen Doherty) and Kelly (Jennie Garth) reunite at the Peach Pit; sparks fly when Annie meets the leading actor of the spring musical; Silver uses her blog to reveal that Ethan cheated on Naomi.
Tabitha offers to direct West Beverly's school musical; Kelly (Jennie Garth) and Brenda (Shannen Doherty) get into a heated conversation about Kelly's involvement with Ryan; Naomi confronts her father's mistress; Annie agrees to a date with Ethan.
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Thursday, March 10, 2011 - Similar notes as below but it presented itself with chicken that elevated the score.
(see all 18 vintages)
Drink 2007-2012
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Hello everyone. It's very late here but I'm wide awake. They were serving chocolate martinis and trays of Godiva bonbons at the Elton John party. I've had way too much sugar. And now I'm on the Internet and watching Oscar recaps on TV. So, what did you think of the Oscar fashions? The colors were very neutral this year, with fewer diamonds. Bling is out. White is in. Everyone looked like a bride. I'm longing for the days when Nicole was wearing chartreuse.
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On 12/1/09 4:34 PM, Chris Lilley wrote: > Unless the stylesheet processor is required to magically fix up the missing closing quote. It is. See http://www.w3.org/TR/CSS21/syndata.html#parsing-errors the "Unexpected end of style sheet" bullet. -BorisReceived on Tuesday, 1 December 2009 21:50:09 UTC
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