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Ray Dalio: Don't Assume That Germany Will Bail Europe Out; Consider The "Fat Tail" A Significant Possibility
Lately, more and more professional investment "advisors" and newsletter recommendations boil down to just one catalyst: wait for either Germany, the ECB or the Fed to step in, as usual, and bail the world out, because, well, they have to, and any additional thought is rendered moot as fundamental analysis is meaningless under central planning (plus it is actually more work than just repeating the same stuff over and over while charging $29.95/month for it). Of course, when these same snakeoil salesmen are asked the simple question: what if said bailout does not happen, or if it happens late (for the purposes of this exercise let's assume one is not a central bank that can print its own money, have an infinite balance sheet, and can afford to be wrong almost into perpetuity), they give a blank stare, start mumbling something and walk away, especially if one mentions Lehman brothers and the simple detail that, oh, it failed. Which is why if Ray Dalio, head of the world's largest hedge fund, is correct, it may time to summarily fire and stop subscribing to each and every broken record Oracle whose template is "X will bailout Y" for the simple reason that it is wrong.
From Bridgewater's Daily Observations:
Be Careful When Betting Against Human Nature
Alliances are shifting in a logical manner. The German-French alliance is breaking down in favor of contributor (higher rated credit) countries aligning against recipient (lower rated credit) countries. Similarly, the terminology to describe who is reasonable and who is unreasonable reflects these parties' respective interests. Those who don't have to contribute use terms like "inflexible" and "irresponsible" to describe the contributors' reluctance to "do enough" to prevent collapse by lending more to recipients who can't service their existing debts, while those who have to contribute use terms like "inflexible" and "irresponsible" to describe the recipients' reluctance to "do enough" cutting of their spending and borrowing to service their debts. Students of human nature and deleveragings know that this is to be expected.
Similarly, talk of a fiscal union to resolve these problems has to be looked at in light of the question of whether it is in the interest of fiscally strong contributors to have a fiscal union with fiscally weak recipients in which the majority rules how the money is divided.
For this reason, we think the popular assumption that the Germans and the ECB (which requires agreement of the key factions within it) will come through with the money to make all these debts good should not be taken for granted. Said differently, we think there are good reasons to doubt that European bank and sovereign deleveragings will be prevented from progressing to the next stage in a disorderly way, without a Plan B in place. This "fat tail" event must be considered a significant possibility.
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Ray Dalio speaketh truth! Time for the MSM to begin attacking him again, calling him a "cult" leader and wut not.
Germany will cave in by the end of July. The alternative for them is even worse.
Never under estimate what total losers the Germans are. They have lost every war for the last 100 years. They are still occupied by the USA. Hell, even Iraq caused enough chaos to make us leave. Germany is the world's bitch. They will pay what ever it takes and will remain the shittiest losers in the world.
Bend over German losers!
ooh, you Stinky Monkey! Drop in .... deposit a nasty turd ... leave without flushing.
"they give a blank stare, start mumbling something and walk away"
mumbling? oh that must be alan greenspan.
Yeah ~ Now try to imagine WHIRRLED PEAS while you're fucking at it... ENOUGH with this horseshit!...
The Missus got a fat tail.
Excellent read by Ray Dalio. Updated March 2012.
Mario Monti is essentially pitching the shit-storm theory. Of course, he'd be a recipient of bailout funds. But for the 3rd largest EU economy to have such dire predictions tells me this will not end well.
Someone might want to cut this out, blow it up, and frame it. I have said this before and I will repeat myself. This will be the first market crash/collapse everyone saw coming, yet did little to get out of its way.
Wow. Long time since I've seen you around. Peace bro...
...and while the Germans are bending over you'll be breathing their gas? Do you remember what happened last time the Germans gassed you?
Wow. Impressive.
Ray Dalio is one of the few people associated with Wall Street capable of independent, logical, thought. His conclusions are the result of unbiased analysis among his team of top notch thinkers. If he says that Germany probably won't bail out Europe, then it's probable that Germany won't bail out Europe. Or at least they may not do it in the way you think. They may let Europe nearly fall into oblivion and then pick up the pieces at the last moment. Why pay top dollar for a bunch of junk that you can wait to pick up for 10 cents on the dollar in a year??
Germans tend to forget now that the euro was largely a Franco-German creation. No country has benefited more from the euro than Germany, both politically and economically. Therefore what has happened as a result of the introduction of the euro is largely Germany's Schuld -- its responsibility.
And remember, just as Germany is grateful to America for the Marshall Plan, Italy would be grateful to Germany for helping it lower its refinancing costs. If it did that, Germany could set the conditions. And Italy would be happy to meet those conditions, because it would benefit from it. Not to recognize this opportunity is a tragic, historical mistake by the Germans.
She is trapped. Merkel has realized that the euro is not working, but she cannot change the narrative she has created because that narrative has caught the imagination of the German public, and the German public has accepted it.George Soros on the Euro Crisis 'A Tragic, Historical Mistake by the Germans'
false. the banking systems of every country benefitted from the creation , and along with them , the politicans, and lastly the people.
it was first in, last out. the people are now losing, soon the politicians will lose and lastly the bankers will finally lose.
banking systems rely ultimately on the power of devaluing money supply ( stealing people's savings ) in order to upkeep their 'solvency'. without theft of deposist, the run by depositers eventually produces a default for the bank ( the end of trust in the bank results in the bankers inability to continue stealing deposits which shuts down his business ).
so------if you want to guarantee someone's right to take deposits , to take without consent, you must rely on the very same soveirgn power that guarantees the states' right to take income and property---to tax.
taxing power is political power, it is police power. the banks have maxed out their ability to steal their depositers money because the depositers are fleeing and buying gold and just getting their money OUT of the banks. If you want to put a stop to this with an even bigger bank, you must first create the political arrangement for forcing the depositers to be confident enough to keep their money in the bank. this will not happen just by 'papering' over the bank. At the best, that will only buy time until the next deposit run. oh yea, and by depositers , i mean at this point the institutional depositers who are dealing with the shadow banking liabilities which boggle the mind in how large they are. actual human beings with small deposits below 100k are basically just hostages along for the ride.
You must convince the people that they have No-where else to save their money, no where to hide, and no inflation to fear. This requires a political authority . America has it, and guess what-----the american banking system will continue to devalue the dollar against gold for the next 20 years as a stable form of stagflationary demise occurs in a controlled manner by the authorities. the plan is assured because of the political will of the police state to enforce the banking systems 'quantitative raping' i meant easing of the quantitative pole up the collective asses of americans for decades to come. i can't wait until obamney gets elected in november for another 4 years.
On the whole I agree with you, but
because the depositers are fleeing and buying gold and just getting their money OUT of the banks.
remember we now have an endoegenous money supply - when depositors are taking their money out of the banks and buying gold, the money isn't destroyed. If the seller of gold deposits the money back into the bank, there's been no net reduction in bank deposits.
Soros fundamentally misunderstands human nature. Bailing out nations engenders humiliation and resentment, not gratitude.
Dalio fundamentally misunderstands power. Germany is slowly being led to understand that it has no real choice in the matter; even now it is merely positioning for the best deal it can get.
Dalio might fundamentally understand his own credibility and be looking to create one last big spook in the markets to buy some assets cheap before the next round of global thermonuclear CTRL-P.
Trust no one.
The Germans have made it very clear that the conditions for progress towards banking and fiscal union is political union. The incentives to do so are obvious: Germany as pay master wants to set up a system of sticks and carrots that, as paymaster to Europe, it must control.
In Europe the politicians recognise this but find it impractical and hard to sell to their own electorates.
UK for example have laid out their table: they will back the German push for political union in the Eurozone as long as the sinlge market remains intact. That is their "Red line" - no going back.
ALL EU countries want the EU to stay and to stay in the EU. So they recognise they have to sign up to greater political union.
So the choice for each country becomes one of single market or single market + single currency. For Euro-member bailout countries, now and in the past, Germany +ECB is clear: No change in conditions for bailout; possibly some change in timing of fulfillment.
The "carrot package" was agreed between Spain, Italy and Germany: 1% of EU GDP to fund growth.
The summit now is about negotiating with Germany over the nature of the "stick" the Germans will bring to the table. MY guess is thast this was already agreed between Spain, Italy and Germany as the former two countries will have to bear the brunt of the stick and there is a lot of politicking behind closed doors about how to structure this because it will not be pleasant for the "socialist/left" leaning governments. OR, they havent come to an agreement as yet. A lack of text in the Von Rompuy/Barrosso/ECB document as reported here in ZH (10 pages became 7") suggests some progress on political accountability but no clear mechanisms in place, it is possible that Germany is making a play for more power behind the scenes and this has not been agreed by everyone.
IF countries do accept more political union/Federal Republic of Deutsch-Eurozone then the negotiations around the summit will centre on the extent of Fiscal control that will be exercised by Germany and the AAA paymasters over national budgets.
But if there are one or two countries that have balked at the idea of the Federal Republic of Deutsch-Eurozone then there will have to be discussion about how they exit the euro and join the UK camp of single market but independent currency.
Merkel has said it with Cameron - Your position implies a "two speed Europe". So there is a significant potential for a surprise out of this summit - where a clear plan for a two speed europe is presented as the way forward, and countries must choose their path of "in the Euro" or "out of the Euro".
I have no idea how the markets will react...
Edit: for those who took the time to read my comment, here is an interview with FinMin of Germany - assuming translation is accurate, it is very insightful into their current thinkig imho - http://www.spiegel.de/international/europe/finance-minister-schaeuble-euro-crisis-means-eu-structures-must-change-a-840640.html
Good note. I believe the markets will rally simply on getting some clarity (even if temporary), but iI wouldn't expect it to last too long.
Thanks, as ZH keeps saying " all the rest is noise", there is only one voice to listen to: Germany.
I try to do that.
The Germans are advocating an EU finance minister and directly elected EU president, plus EU law transferred from EU commission to EU parliament.
They are going hell ofr leather on this one - this summit could be the biggest overhaul to the EU since the Maastricht Treaty
Those in Germany who advocate any such nonsense are suicidal. This would only end with the total financial destuction and disolution of sovereignty in Germany. And "Der Spiegel" is a leftist trash publication.
That is what Schauble said, read the interview. So they are advocating it. and all news today out of the Finmin meeting yesterday evening, including France - is that EU integration is being discussed -
Rajoy today went back on political promises, says EU supervision on fiscal budget is coming, get used to it; French Finmin saying " we discussing integration, French will have to get over the loss of sovereignty", Italians are for Integration, Greeks voted it in, so who is standing in the way?
And the rest will happen rapidly - banking union, fiscal union,
may be a good time to shift towards a long position ..... on the banks................... while market talk is still about "Nationalist interests are going to crash this summit, no deal expected, etc.... " market and media are talking down expectations below what I'm reading but hey ho each to their own
yea I remember we took over your checkbook hollywood and wall st. now swallow shnuck
No, but I remember how Germans were barbecued in Dresden I bet it smelled like a hot dog on the 4 th of July.
Will Germany ever learn they are the world's slave?
Germans weren't bombed in Dresden because they were the world's slaves, pup. They were on the verge of being the world's masters. Seriously close to global domination. That is what is in the German blood - never forget that pup, and be afraid instead of arrogant. Or maybe you are afraid and that's why you're talking trash...brave here on the board but a real coward when things get real...right??
World domination is overrated. It's as noble an aspiration as getting mounted by a horse.
The Dresden instance, it turns out, was the most famous act of cowardice combined with treachery and pointless killing in history.
Is this not now the era of terror and the era of lies?
Perhaps that "greatest generation" in World War II learned a lot about terror and government trust. Every word of the Associated Press reports in the war, for example, moved through U.S. government censors and direction…
Thus the significance of AP's coverage of the horrendous and relentless bombing of Dresden, Germany in February, 1945.
"This unprecedented assault in daylight on the refugee-crowded capital, fleeing from the Russian tide in the East," the AP correspondent reported from Supreme Allied Headquarters in Paris, showed that "the long-awaited decision had been taken to adopt deliberate terror-bombing of German populated centres as a ruthless expedient to hasten Hitler's doom."
Note the objective of the Allies: "terror."
The gloating in those words rings all through our era, from the unconcern for women and children burned in the streets of Dresden because they were Germans to the apathy concerning families slaughtered in the Middle East because they are Muslims.
Now, the AP tells us the King of Terror is dead.
Look in the mirror cheering youngsters: do you know if you can recognize the real face of terror?
The ancient cultural center of Dresden, a city rich in 18th century architecture, was not a military or industrial target so it had little or no anti-aircraft weapons as an air attack was not anticipated. As the war was winding down, Russian forces were sweeping across Germany from the East and Dresden's normal population of 600,000 had recently swollen an additional 300,000 to 500,000 with refugees fleeing the Russian advance, now only 70 miles away.
Dresden had no air raid shelters; every public building was crowded with refugees, mostly women and children, and many were camped in the streets.
The first attack came at night…about 9:30 p.m. … as the British Royal Air Force sent in more than 800 heavy bombers. All planes returned to base safely. And while heavy black smoke covered the city next day, an armada of bombers went back to give it everything they had - 1,350 Fortresses and Liberators. The following day, 1,100 U.S. 8th Army Air Force bombers hit the devastated Dresden a third time.
In 36 hours, perhaps, 250,000 people were killed…funeral piles of 500 bodies each burned for days.
Some isolated anguish over the Dresden attack brought to light details of a pattern of RAF terror bombing under the Linderman plan first used in March, 1942. Professor Frederick Linderman, scientific advisor to Churchill, reasoned that bombing German residential working-class areas and smaller cities would be easier to hit than military and industrial targets, would provide greater concentrations of death and destruction, wouldn't be as dangerous to pilots and would help the population urge their leaders to surrender
For God's sake JR! Really?
Yes, the bombing of Dresden was one of WW2's 'nominees' when put on the scale of 'Morally Questionable Acts', but let's just keep it in perspective, when considering all the acts of horror and evil committed by the proven 'aggressor' that started the whole abhorrent episode that's blotted mankind's history ever since. Sure... 250,000 germans were killed in an horrific episode in Dresden... but would you care to comment on how that compares to the 6,000,000 systematically murdered at Sobibor, Treblinka and Auschzwitz? (For the record, I'm in no way, shape or form a supporter of Israel and its despicable record of similar acts of intolerance and cruelty and segregation against the Palestinian people, in a manner which mirrors how their fore fathers and mothers were treated between 1936 - 45 with shocking similarity.)
When one considers the shear magnitude of what the Germans did to the Jewish people of Europe for near on a decade… the manner in which it was coldly, brutally and systematically undertaken and what the psychotic, hysterical and hate-felled rationale behind this 'final solution' actually was in the minds of both the Nazis and German people alike, to then attempt to turn around and accuse England of committing the '... the most famous act of cowardice, combined with treachery and pointless killing in history...' is nothing short of truly pathetic, unbelievably ignorant, grossly ill-informed… and basically nothing more than a tragic display of shear stupidity, from a mind that's clearly delusional beyond measure.
It's pretty clear that who ever the owner of this redundant grey jelly is, should be closely monitored by professionals at all times and under no circumstances ever be allowed to venture out in public unsupervised for fear of what they could potentially attempt to try and tell people about their version of history that they believe is based in fact. Even worse, they could potentially congregate with other equally retarded people once a year and protest en-masse, the Dresden Bombings and accuse England and her allies of 'war crimes' or 'crimes against humanity' or some other such equally idiotic claim, for which the insanely enormous hypocrisy inherent in such a moronic accusation is totally lost on many younger Germans who are intent on giving credence to this ridiculous claim that their parents and grand parents were innocent victims of Churchill's barbaric acts of slaughter, when in fact they were probably standing guard to the entrance of Oven 4 as another few thousand men, women and children were made to assemble for their 'shower', before being blasted to ash in the furnaces below.
Instead of trying to rewrite history and make yourselves out as the innocent by-standers to your former leaders' mass murder and atrocities, why not just stick to making really good automobiles, continuing to produce high-grade 'Porn' that, even though fascinating in one sense, in all honestly actually just boarders on being 'sick' and pooh'ing all over your partners breasts while having sex!
Just sayin.
If you think that post was "truly pathetic, unbelievably ignorant, grossly ill-informed," you should read what some of these other whacked-out goofball libertarians have to say. The super-goons who bury canned hams and shiny metal in their backyards are typically the same ones that also think the holocaust was entirely fictional.... and 9/11 was an inside job and Osama had been frozen since 2003..... and death panels.... and etc etc etc....
Weirdos and eccentrics TO THE MAX!!
Yet truly fascinating, nonetheless... in a "Jerry Springer Live from the Lincoln Park Zoo" sorta way.
The murder of the Jews is an historical fact, and an abomination. As was the bombing of Dresden.
I do not see how one justifies the other. The big difference is that the victors hung the losers.
Well, there is no guessing as to your ethnic origins.
Are the negative arrows from the use of the word pooh'ing?
So you are saying just because they were bad, we have the right to be as bad? Is that your solution? Genius.
Keeping the higher moral ground counts a lot more than terror. If only the USA had learned that before randomly bombing Iraq.
@ Salamanda…
In the years following the end of WWII and the trial of surviving German leaders conducted by the victor, the Western press has been the constant spokesman for the Zionist view of history, the constant drumbeat of Holocaust stories, the intimidation of any individuals who do not repeat constantly the "never again" mantra. This lack of press freedom I am not debating here. I am suggesting here the cowardly act of hate involving primarily the Royal Air Force and Western allies as completely unappreciated in the so-called moral high ground of the Allies.
My emphasis on this greatest act of cowardice was meant to underline an importance to it that is still in our modern life being ignored.
I am just sorry I was not here to refute you earlier; you will do and say anything to bring up your Holocaust, not every year and not every month and not every day, but continuously. And no heinous act, no matter how great, is allowed to compete with that message. And you say the power and the horror lies with the German people.
"And for those who are sick of all the Hitler parodies…"
Consider developments after WWII:
In 1947, a defeated, divided, truncated, occupied Germany was a mass of rubble, its economy a desperate scratching for subsistence.
Although the Marshall Plan enabled Germany's people to rebuild a free society and a free economy, a predecessor blueprint for genocide became the on-going principal occupation policy directive – a policy that aimed at the destruction of a nation's people. It was the Morganthau Plan, drawn up by America's wartime Zionist Secretary of the Treasury, Henry Morganthau, and his closest advisory, Harry Dexter White (a member of a Communist espionage ring in Washington while he served as Assistant Secretary of State).
It aimed at the permanent destruction of Germany's industrial heart and the consequent death through starvation and disease of millions and tens of millions of Germans. Time magazine has aptly called it "history's most terrifying peace".
The conservative newsletter, Review of World Affairs, quotes the plight of the German people after the war as follows from a confidential memorandum prepared by an eminent European economist:
"Since the end of the war about 3,000,000 people, mostly women and children and over-aged men, have been killed in eastern Germany and south-eastern Europe; about 15,000,000 people have been deported or had to flee from their homesteads and are on the road. About 25 per cent of these people, over 3,000,000, have perished. About 4,000,000 men and women have been deported to eastern Europe and Russia as slaves…." Quoted by Sen. Homer Capehart in speech before U.S. Senate, Feb. 5, 1946.
Dr. Lawrence Meyer, executive secretary of the Lutheran Church, Missouri Synod, after a tour of Germany at the time stated: "About 16,000,000 German refugees east of the Oder are being deported from their homes. It has been estimated that already 10,000,000 have been driven out. The human tragedy and suffering caused by this 'Volkswanderung' are unparalleled in history…"
An authentic eye-witness reported…
"A large barge is slowly being towed across the Oder River. In it, lying on straw, are 300 children ranging from 2 to 14 years of age. There is hardly a sign of life in the whole group. Their hollow eyes, their swollen bellies, knees, and feet are telltale signs of starvation. These are merely the vanguard of hundreds of thousands—millions of homeless, shattered, hungry, sick, helpless, hopeless human beings fleeing westward – west of the Oder and Neisse rivers.
"A trust in God—in his goodness and mercy—these are the only hope of Germany today. And thank God in many there is still faith in God against which the gates of hell have stormed in vain during the past decade." (Capehart)
Dresden was the communications and transport hub of the Germans Eastern front.
The attack was designed to foil resupply of German armies in the east (largely at the request of the USSR, prior to a large offensive if I recall correctly), and it was quite successful in achieving that.
Civilian casualties were collateral damage of minor consideration at the time, albeit the morale effect was valued by Allied planners.
You are just regurgitating a rationalization given by the air force years after the event. Undoubtedly one reason was morale/psychological; but to say that killing almost exclusively women and children is a justifiable war aim seems evil in the extreme.
+1 particularly because the planners were very keen on finding out if their theory of the "ring of fire" would work: by bombing Dresden in a concentric circle and starting a solid line of fire that would suck itself in and kill everything inside - using less bombs than the usual carpet bombing. And this plan was already old by then, with Dresden being "spared" until "ripe" for it. In the context of WWII there were many of those "total war" plans and techniques being explored, and many planners fully expected that they would be needed for a second round against Russia.
"Slaughterhouse 5" Kurt Vonnegut. American POW sent to work at a Slaughterhouse on that fateful day if you want a full account.
No, it doesn't SEEM evil, it WAS evil. Not a difficult thing for Churchill, as he WAS evil. Then again, one of the first thngs propagandists do is to dehumanize the enemy. Hence, Germans became the "Huns." This was particularly egregious, as the Brits and the Germans are virtually from the same genetic stock.
There was no "gassing". Never happened. That's just Holohaux BS. If you visit http://www.codoh.com/ you can get some facts on this issue that -- and this should be a red flag to you -- in many countries is illegal (and even dangerous) to freely discuss and research.
Sabibaby, you confuse Germans with Nazis, TWAS THE NAZIS & THEY CAN FREEZE IN HELL WHILST THOSE ON THE RIGHT PATH WILL FEEL THE WARMTH OF THE LORD!
Well if fighting everyone at the same time is what defines the German people then logic dictates they will take the high road and tell everyone to go f themselves and drop out of the euro.
And whats with the hate? Does it anger you how successful they are as a nation?
Do you define success as losing wars and being occupied? Now sell me a high quality car for some fancy green paper!
What goes around comes around. That fancy green paper will come back to bite you in the ass. Germans will never be bitten in the ass for being excellent engineers and for knowing how to make a fucking car unlike Detroit. Even Ford makes the new 2013 Fusion, which just might end up being a good car, in Mexico. Gotta go to fucking Mexico for quality builds.
"Gotta go to fucking Mexico for quality builds"
They go there for cheap labor like all the globalist corporations. The factory installed oil leak is a design 'feature' ... not a bug.
"Gotta go to Mexico for quality buds."
What's wrong with Humboldt, American made?
centerfold BiCheZ!
Kia and Hyundai build cars in Georgia and Alabama all day long.
Unfortunately - Ford and Oba-GM, Oba-Fiat-Chrysler are hostage to UAW thuggery and cannot set up plants in right to work states. Americans can build good cars but not in UAW factories. Even the hard core marxists in Turin chrun out higher quality in a Fiat than the sh*t Chrysler makes.
Willard Romney will not save you
you're up kinda late. can't sleep?
then tell me one war USA won in the past 67 years? Germans save themselves trilions keeping americans on their soil and if Gemrans paid so far, that money went back to german banks anyway, they will remain the greatest nation in Europe, if not the whole world, although only because competition cant see on both eyes.
"and bail the world out, because, well, they have to"
We DON'T "have to".
Let them fail, and see how INCONSEQUENTIAL the event really is.
Remember Y2K ??
"Paper" losses need "paper" cures.
We will blow ourselves up over what???? BANK LOSSES???
I don't think so. TOO many other sectors of our economy.
"and bail the world out, because, well, they have to"
We DON'T "have to".
Let them fail, and see how INCONSEQUENTIAL the event really is.
Remember Y2K ??
"Paper" losses need "paper" cures.
We will blow ourselves up over what???? BANK LOSSES???
I don't think so. TOO many other sectors of our economy.
War against poverty
War against drugs
War against racial emnity
War against environmental disaster
War against illegal immigration
War against big governnemt
War against inflation
War against economic inequality
Jesus, none so far....
War against peace
Yeah, that's the ticket
We won the war against peace.
we recently hosted a 16-year-old German exchange student. he knew a hell of a lot more about finance and politics than my high schoolers, and probably more than about 98% of American "adults."
people are people. you put anyone through enough economic hell, and they will look for a strong hand to lead them out, and to cast out the people who are "to blame." what happened in Germany pre-WWII could happen anywhere in the world as a result of the current financial crisis.
Germans are some of the best engineers, and some of the most hardworking and well-educated people on this earth, on average. Even the name for your sentiment is German: Schadenfreude.
Just one wrinkle pops, a wave of Nationalism takes hold of the Germans every 70 odd years and they are the cause of World Wars and may very well be the scapegoat for the next one, motivated by austerity rather than American Imperialism.
That is just how we want it. Learn our language, build us things, buy our bonds. Germans are filling their role as the rest of Europe's and the USA's slave. See who is smarter?
you know there's a DSM entry for this condition?
You can't have it both: high moral standards and let moral hazard happen, but this what they are demanding from Germany.
"what happened in Germany pre-WWII could happen anywhere in the world as a result of the current financial crisis" Indeed. Looks like the US going to get a 'taste' of it sometime in the near future. However, I happen to disagree about German engineering... I think their German companies actually want to build good stuff therefore ENABLE their engineers to perform well whereas American companies (or what is left of them with only a few exceptions) only want to cut corners whenever possible (I know of perfect examples) therefore crippling their engineering and ultimately their product and markets.
my brother was an exchage student over there in the eighties and came to the same conclusion. Said their high schools were way ahead. .
Sadly, as Germany dumbs herself down through the importation of third-world parasites, and lowers the quality of her products by manufacturing in China (although, STILL marked as "Engineered in Germany," your beliefs about German education and work-ethic are becoming less true each day.
Sarrazin's book covers this well.
So you're proud that exchange students knew more than your children? So who do you you blame, the "system" or the parents? I've raised and taught foster children of all races and I can't see a difference. If I wanted to fuck with your head I would say that the Asian children I've raised actually have superior learning skills.
I never thought about it like that but in a twisted focus on reality it is true................. good insight !!!!!!!!!!!!!!!!!
Point of history: The Germans were winning in both cases until the US got involved. And even then, it was not a given. That said, both world wars were unnecessary fraternal tragedies. Tke first, fomented by the ruling houses of Europe for no good reason, and the second, born out of the inhumane Versailles Treaty.
- a treaty which was more humane for the Germans than what they received after the Second World War.
France lost every war. Germany didn´t win either, but France lost.
Wow! You scored a -93 at the time I wrote this. I dont think I've ever seen that here before. Not even MDB, Impressive. You really hit a nerv.
To allow German reunion has been the great mistake and the first step of European deficit explosion.
Now we get their "NEIN"
Keep loaning money to deadbeats so that you can sell products back to them or suffer through a recession/depression to reset your economy to the point where you aren't relying on loaning money to deadbeats so that you can sell products back to them. Either way, you have to eventually face the alternative. Therefore, I don't think the "alternative" is worse, it just needs to be faced sooner.
Germany will cave in by the end of July. The alternative for them is even worse.
Dont be so sure. The Germans are a lot better at math than we in the States. We foolishly coughed up $16T to bail out US banks on the premise they'd collapse otherwise and take our deposits w/them. No one ever bothered to consider that there were only $9T in deposits to be backstopped. Said differently, we could have bailed out almost 2 US banking systems with what we paid. (And that doesnt even count the $10T extra in CB swap lines.)
And yes yes, I know the real elephant in the living room is the derivatives pile of S that's larded on top of everything. But even here, we still could have backstopped the deposit base, declared force majeure, and canceled the derivatives contracts. After all, they're all offsetting on a net basis anyway, or so the banksters tell us, so there's no problem....right?
Do the right thing Germany (unlike us in the US) and tell the banksters to cram it.
@Withdrawn Sanction
Couldn't up vote your comment because of the italics field. Well said.
agree. It is sad that we are waiting and watching for Icelanders, Germans, and a host of others to do what our den of thieves called a government refuses to do.
Likewise tried to vote up but was defeated by the strange anti-vote up field (obviously of German manufacture) surrounding your comment!
I just want to say bravo. This is the rub right here. We could have bailed out and backed two banking deposit bases, but instead the said banks doubled down and the base is still not ring fenced. Why the fuck is no one in prison? It goes all the way up is why! What is ailing this country, at heart, is a full on social breakdown of law and order.
and indeed the German government has told the banks to "stick it where the sun don't shine." indeed they have. the last time they did this "they ended up invading Russia." i don't think THAT will happen this time tho. Oh, well. We can always dream...
too much star power that doesn't know what they're doing on that one. How about this one: http://www.youtube.com/watch?v=HcrSn2uUAyA
Who knows, they might end up invading Russia once more! But this time they could have allies from the (far) east... Would the US move to prevent a war between Germany-Russia and China? I don't think so! I imagine they would instead put all their effort in making India enter too, so as nobody wins, everybody is weakened enough and they later come along as saviors conficating any gold unearthed by the bombs.
One has only to survive and see what happens...
The Germans elected an Austrian usurper with disastorous conseqences. He actually did not win the majority of any vote. The USA elected an ineliigible Kenyan/Indonesian muslim and CIA cutout usurper with a majority of the vote by idiots who watch TV with disastorous conseqences. They voted who Oprah told them to vote for including white women.
The Germans sometimes have some stupid leftist inclinations at times but they are generally pretty smart. They want the Deutsche Mark back and I think Ray D may be correct.
The US and Americans have no clue about pretty much anything anymore. It is sad and pathetic.
The Central Banks will print. It is fait accompli.
Really? I would love to see Reichsmarks in circulation again. And now that Berlusconi is running for his comeback on a platform of returning to the Lira, the big bet is will we see Reichsmarks before we see Lira, or the reverse?
Has the world known bigger, more pathetic losers than the Germans? I think not. You are the world's sex toy. You buy our bonds, furnish our fine automobiles, you house our troops. At least you know your place, filthy Huns.
Now send me a hot blond chick!
I am trying to do the Germans a service. I want them to know they are going to have to work hard and build high quality products and they will take their profits and give them to Greece, France, Italy and the USA. That's what pussies do, give away the fruits of their labor. Get used to it!!!
And therein is the real, overall, master plan of the USA.
Let the world get used to defaults - umpteen of them throughout Europe, followed by Japan and the UK.... and then, hey presto, we got 'let off' our 16 trillion and what's more it was (relatively) a bit of a non-event.
Happy Days!
You got it.
It is an interesting approach to call them "filthy huns" with the aim of doing them a service.
I will try something along this line with my neighbor, next time I want something from him.
if my neighbor needed something and i could help her, she could call me a shitheaded asswipe and i'd still give it to her with compound interest
That DOES seem to be the master plan. And since the Germans have been cowed into a permanent state of guilt over that little Austrian corporal who led their grandparents into disaster, they basically ARE pussies who won't even fly their own national flag unless it be during a soccer championship.
And I say this as a Germanophile who lives near Frankfurt with many German friends.
Ze Germans like Greek boys and girls, the younger the better. Returning to the Drachma will make things soooo sweeet for Germany's hordes of perverts. Sexual Tourism is Greece's future, and Ze Germans will be the biggest customers.
Some German dude must have fucked your girlfriend.
Speaking of fat tails, check out this crazy shit. http://www.scribd.com/doc/93058461/LAWSUIT-Complaint-SDNY-11-23-2011-Neil-Keenan
That crazy, tin foil shit that Fulford has been spewing about, the missing trillions, gold, etc., has finally showed up in a lawsuit filed in NY. I googled the attorney of record and they are the real deal. High powered with a bunch of awards. I sure don't know what to make of it but it all ties in with those bonds that were confiscated going across the Italian border last year. If you read the complaint it is some wild shit! Apparently the judge that was assigned the case just resigned, I don't have any particulars on that. If this is anywhere close to being true then there is some wild moves happening below the surface. I'd be ready for anything to happen as this goes to the highest branches of several countries, including/especially the U.S.
Fulford laces his tin foil stuff with some true stuff from time to time. My partner really gets into him. But he does come across the real deals with regularity. What you read is true.
There's a lot of shit flying below the radar right now around the world. It's a lot of black ops stuff.
'Bank of Nova Scotia via ScotiaMocatta'
It's interesting to see wealth redistribution being rejected when it's asked for internationally.
Shame we don't have the same option domestically.
It's interesting to see wealth redistribution being rejected when it's asked for internationally.
Shame we don't have the same option domestically.
Of course we do. The opportunity arises at least every 2 years..... it's called voting at an election.
Voting for Tweedle Dum or Tweedle Dumber ain't much of a choice! Both parties are vacant of any thinking.
Of course we do. The opportunity arises at least every 2 years..... it's called voting at an election.
Hmmm Last time I looked, I was still paying taxes imposed upon me by a government that got elected by people who'd be on the receiving end. Despite my having the vote.
'A government that robs Peter to pay Paul can always rely on the support of Paul'
Never under estimate what total losers the Germans are. They have lost every war for the last 100 years. They are still occupied by the USA. Hell, even Iraq caused enough chaos to make us leave. Germany is the world's bitch. They will pay what ever it takes and will remain the shittiest losers in the world.
Bend over German losers!
Sorry, but I didn't understand this the first three times you posted it, so can you post it another three times for clarity?
No, but I will say that Germany will pay anything, and I mean anything ANY country asks them to pay. Why? Because theynare emasculated bitches. They work hard so the rest of the world doesn't have to. I am headed to Germany soon. Maybe I can find a few blond haired blue eyed woman to pimp out. LOL!
Probably you are right, because WWII never really ended.
So true. WWII never ended, but it is clear that Western Civilization was the loser.
My father unknowingly enlisted in what would turn out to be the War to make the world safe for communism. 25 years after the end of that war I earned the same campaign ribbon that my father earned "United States Army of Occupation Europe." Indeed, some wars never end.
And the attack upon the West by its own elites, both alien and native, continues.
What would you do for a dear relative asking for the 5th loan this month.
Fat tail. My favorite.
+1 for the scary avatar.
Yep. I could never leave her behind.
~ Spinal Tap
Dalio lays out the obvious as only a cool head can. A year from now thousands of money managers will be saying "how could this happen to such fine 'very old' [ref. de Villepin] countries? Unthinkable!" and we'll just print this post for them, as we did with Kyle Bass' posts and Michael Burry's interviews.
God...What I wouldn't give to see a pay-per-view debate between Dalio and some fucktard like Steve Liesman.
Sept. 15 (Bloomberg) -- Ray Dalio, founder of Bridgewater Associates LP, discusses the European debt crisis, investment strategy and the global economy. He speaks with Erik Schatzker at the Bloomberg Markets 50 Summit in New York.
Liesman is paid to be a cheerleader
as Dalio is paid to see reality. excellent point. people excel most at what they are compensated/evaluated on.
100% correct. Good post.
The Euro was developed with a plan and a purpose...to survive. No where have I read of a plan to bail each other out of indescriminent spending. Certainly not the long term,structural kind that comes with socialist programs for age security and healthcare (the kind politicians rather than insurance companies dream up.)
"The Euro was developed with a plan and a purpose...to survive."
No, it was designed to fail:
And civil war is such an ugly thing . . .
"The Euro is a burning building with no exits." (William Hague)
I just love watching stuff burn.
I dont think people have a clue as to how the ECB works including dear old Ray. Get with the program Ray, the truth be told, the ECB can , in theory, run over the votes of Germany. The ECB runs by simple majority vote in the end. Germany has been overruled many times already (Axel Weber on Bond Purchases) and now you can guess the LTROs and lowering of credit quality.
Ray Dalio is a financial Einstein. He has a cult culture that is based on hypothesizing everything... with 5,000 employees doing this day in - day out.
And... who are you?
It works every day, until it doesn't. Getting cocky means the end is near.
If i had a euro for every time a financial einstein spouted shit to the masses and dogs like you lap it up as if it were pearls of wisdom i could bailout the EZ by now. What he says about the ECB is just plain wrong. WHat the hell does he mean by "key elements"?. Germany has been bitching while Draghi has been doing the slapping...get your cheek in line biatch cause your next.
Repeat question:
Who are you?
It looks like the answer is self-evident.
Germany can leave. Then the ECB will be free to print to infinity and beyond, they will, and the Euro becomes a Drachma. You won't want to hold Euros after Germany leaves.
Andrew. Germany can leave? Really?? I guess so, but not after if it gets fucked over on 1 Trillion plus Euros of money its owed. Oh and less you have forgotten, some 70% of Germany's current account surplus is within the EZ. Germany would be like the US in the great depression.


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Publications (62)310.74 Total impact
Article: Radiologic and Pathologic Response After Neoadjuvant Radiation Therapy for Myxoid Liposarcoma of the Extremities
Article: Management of Unplanned Excision for Soft-Tissue Sarcoma With Preoperative Radiation Therapy Followed by Definitive Resection[Show abstract] [Hide abstract]
ABSTRACT: Background and objectives:: The purpose of this study was to review the outcomes after preoperative radiotherapy and definitive surgery for patients who initially had inadvertent excision for sarcoma. Materials and methods:: Treatment records of 44 consecutive patients, who initially underwent unplanned excision of soft-tissue sarcoma between January 2004 and January 2012, were reviewed. All patients had clinically localized disease before treatment and received preoperative external-beam radiotherapy followed by definitive oncologic surgery at our institution. Results:: The median follow-up was 36 months. Residual tumor after preoperative radiotherapy and wound bed excision was identified in 39% (17/44) of the cases. Kaplan-Meier estimates for 5-year local control, recurrence-free survival, and overall survival are 95% (95% confidence interval [CI], 80-99), 86% (95% CI, 69-94), and 94% (95% CI, 79-99) respectively. Perioperative morbidity occurred in 25% of patients (11/44.) All patients with perioperative wound complications had lower extremity sarcomas. Conclusions:: Optimal management for unplanned excision of soft-tissue sarcoma is unknown. Our institution has adopted the approach of preoperative radiotherapy, followed by definitive surgery. In our series of 44 patients, local control was excellent at 95%, with perioperative complications seen only in patients with lower extremity sarcomas, suggesting that this is a reasonable approach to manage inadvertently resected sarcoma.
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ABSTRACT: Background: Cardiovascular-related toxicities have been reported among survivors of osteosarcoma. Methods: Fasting blood samples from 24 osteosarcoma survivors were analyzed for high-sensitivity C-reactive protein (hsCRP), triglycerides, total cholesterol, high-density lipoprotein (HDL), apolipoprotein-ß, lipoprotein (a), fibrinogen, circulating endothelial cells (CECs), and surface expression of vascular cell adhesion molecule-1 (VCAM-1). Values were compared to subjects in the natural history Coronary Artery Risk Development in Young Adults (CARDIA) cohort study except for CECs and VCAM-1 expression, which were compared to controls studied at the University of Minnesota Lillehei clinical trials unit. Procedure: Survivors (54.2% male), median age 18 years (9-32) at diagnosis, 36.5 years (20-56) at evaluation were treated with a variety of chemotherapeutic exposures, all but one were exposed to doxorubicin (median dose 450 mg/m(2) ; range: 90-645 mg/m(2)), 14 (58.3%) received cisplatin, and 3 (12.5%) were exposed to carboplatin. Two survivors (8.3%) received radiation therapy for disease relapse. Compared to CARDIA subjects, mean hsCRP (3.0 mg/L ± 2.0 vs. 1.6 ± 2.3), triglycerides (151 mg/dl ± 81.7 vs. 95.4 ± 101.3), lipoprotein (a) (34.9 mg/dl ± 17.7 vs. 13.8 ± 22.0), and fibrinogen (315.0 mg/dl ± 49.3 vs. 252.4 ± 61.7) were significantly elevated. The number of CECs (0.47 cells/ml ± 2.5 vs. 0.92 ± 2.5) did not differ while surface expression of VCAM-1 (86.4% ± 34.0 vs. 42.1 ± 33.8) was significantly elevated compared to controls. Conclusions: Among survivors of osteosarcoma, assessed a median of 14 years from diagnosis, there is evidence of vascular inflammation, dyslipidemia, and early atherogenesis.
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ABSTRACT: BACKGROUND: Soft tissue sarcomas are a heterogeneous group of malignant tumors. Standard treatment for soft tissue sarcoma of the extremity is surgical excision and adjuvant therapy; however, the role of neoadjuvant chemotherapy is controversial. QUESTIONS/PURPOSES: We sought to (1) define the histologic characteristics of the pseudocapsule in soft tissue sarcomas; (2) compare the appearance of this structure in chemotherapy-treated versus untreated soft tissue sarcomas; and (3) evaluate the effect of chemotherapy on the presence and viability of tumor cells at the host-sarcoma interface. METHODS: Twenty-eight patients with biopsy-proven, deep, high-grade extremity soft tissue sarcomas greater than 5 cm (AJCC stage III) treated with chemotherapy and surgical excision were compared histologically with 47 matched control subjects treated with surgery alone. RESULTS: A pseudocapsule was identifiable in the majority of tumors and consisted of two identifiable layers, each with specific histological characteristics suggesting the biologic processes occurring in these layers are different. The pseudocapsule was more frequently observed in the group treated with chemotherapy and it was more frequently continuous, thicker, and better developed in this group. Chemotherapy decreased the number of tumors with malignant cells identified within and beyond the pseudocapsule. CONCLUSIONS: Neoadjuvant chemotherapy contributed to the development of a pseudocapsule and decreased the number of tumors with malignant cells identified within and beyond the pseudocapsule. CLINICAL RELEVANCE: These findings may provide a histological explanation for the clinical effect of chemotherapy in soft tissue sarcoma. LEVEL OF EVIDENCE: Level III, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.
Article: Lentivirus transduction of human osteoclast precursor cells and differentiation into functional osteoclasts[Show abstract] [Hide abstract]
ABSTRACT: Gene transfer into stem cells has been an ongoing priority as a treatment for genetic disease and cancer for more than two decades. Methods described herein, form the basis for providing the cell source to determine if osteoclast precursor cells (OcP) can be used as therapeutic gene delivery systems in vivo. Osteoclasts and tumor associated macrophages or OcP, support survival, tumor progression and osteolysis in bone cancers. Two sources of precursor cells are compared: CD14+ cells, the standard OcP, found abundantly in peripheral blood and CD34+ cells, hematopoietic stem cells that are rare, but which can be expanded into OcP. Our findings characterize cell yield at each step of the transduction process and thus provide essential data for planning future in vivo experiments. In addition we demonstrate that essential functions of OcP are preserved following lentiviral transduction. Specifically, neither the transduction method nor the lentiviral transduction influence the OcP's ability to form osteoclasts, express the marker gene, EGFP, or resorb bone. Finally, we conclude that CD34+ cells yield significantly more transduced cells and form functionally superior osteoclasts in vitro. This study represents a step towards considering human gene therapy for bone cancer by demonstrating successful transduction of human OcP for use as cellular delivery vehicles to sites of bone cancer.
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ABSTRACT: In 2005, cancer was second only to heart disease as the leading cause of death in the United States. There are 1.4 million new cases of cancer diagnosed each year resulting in over one-half of a million deaths. Due to improvements in detection and treatment, longer patient survival after diagnosis is now possible. Unfortunately, the quality of life in patients dealing with advanced cancer is significantly reduced. A major contributor to the overall decreased quality of life in such patients is bone cancer pain [12, 45].
Article: Response of imatinib-resistant extra-abdominal aggressive fibromatosis to sunitinib: Case report and review of the literature on response to tyrosine kinase inhibitors[Show abstract] [Hide abstract]
ABSTRACT: Aggressive fibromatosis (AF) is usually a slowly growing locally invasive tumor, but may exhibit a much more aggressive phenotype. The role of chemotherapy in AF is not well defined, but can be useful in some cases. We examined the response of a case to both imatinib and sunitinib. We report a case of an aggressive multicentric extra-abdominal AF that was responsive to sunitinib, but resistant to imatinib. A 23-year-old woman developed painful multifocal AF of both legs and gluteal muscles that progressed after surgery and treatment with methotrexate/vinblastine and pegylated-liposomal doxorubicin. She received six cycles of ifosfamide/etoposide (IMV), and obtained a good response with elimination of pain. After 5 months, she developed progression and again received six cycles of IMV, with cessation of symptoms. After 13 months, tumors recurred. Although the AF was symptomatic and progressing, she was hesitant to receive chemotherapy and began treatment with sunitinib 50 mg/day for 28 days of a 42-day cycle. At 4 months, she could walk on her heels without pain. After 13 months of sunitinib, therapy was changed to imatinib 400 mg/day; after 7 days she noticed increasing pain in the AF lesions and decreased knee flexibility. Imatinib was continued, but after 2 months of imatinib, she could only walk a few steps due to pain. Sunitinib was reinstituted at 37.5 mg/day and symptoms improved within 1.5 weeks, with a marked reduction of symptoms at 1 month. She was doing well with a normal activity level, 32 months after initially beginning sunitinib. We conclude that sunitinib may be useful in some cases of AF.
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ABSTRACT: Subpubic cartilaginous cysts were initially described in 1996 with few reports to date. We describe a 62-year-old woman with a history of breast cancer who presented with a painful, fixed, vulvar mass. MRI revealed an 18 x 10 x 12 mm3 mass extending from the anterior portion of the symphysis pubis without bony involvement. Excision was performed. Histologically, the mass consisted of fibrocartilage with extensive degenerative changes, compatible with a subpubic cartilaginous cyst. Over 24 months later, there has been no recurrence. Subpubic cartilaginous cyst is a rare, benign lesion occurring on the vulva and should be considered in the differential diagnosis of a painful, superior vulvar mass.
Article: Addition of receptor tyrosine kinase inhibitor to radiation increases tumour control in an orthotopic murine model of breast cancer metastasis in bone[Show abstract] [Hide abstract]
ABSTRACT: The receptor tyrosine kinase inhibitor, SU11248, was added to localised radiation to evaluate the response of bone metastases and to define the basic mechanism of radiosensitisation. Treatment with SU11248 and radiation was assessed in vitro using cultured 4T1 breast cancer cells and in vivo using an orthotopic 4T1 murine mammary tumour model of breast cancer bone metastasis. Cultured 4T1 cells treated with SU11248 (1 microM) and radiation (10 Gy) showed an almost 7.5-fold increase in caspase-mediated apoptosis after 24 h of incubation, compared to either treatment alone. Mice treated with SU11248 (40 mg/kg/daily) and radiation (15 Gy/single-dose) had a relatively greater reduction in tumour growth, bone osteolysis, osteoclast maturation and microvessel density. Combined modality treatment resulted in improvements in behavioural pain assessment scores and normalisation of neurochemical changes in the spinal cord receiving primary afferent innervation from tumour-bearing femora. Our study demonstrates that SU11248 enhances the radiation control of metastatic breast tumours in bone and tumour-induced pain.
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ABSTRACT: Establishing the best diagnosis for musculoskeletal neoplasms requires a multidisciplinary approach using clinical, radiographic, and histologic analyses. Despite this rigorous approach, establishing accurate diagnoses and prognoses remains challenging. Improved diagnostic methods are expected as unique molecular signals for specific bone and soft tissue cancers are identified. We performed a systematic review of the best available evidence to explore three major applications of molecular genetics that will best benefit clinical management of musculoskeletal neoplasms: diagnostic, prognostic, and therapeutic applications. The specific questions addressed in this systematic review are: (1) What sets of histopathologic sarcoma subtypes will benefit from molecular evaluation and diagnosis? (2) What molecular methods are best applied to histopathologic sarcomas to distinguish between major subtypes? (3) How do the molecular patterns discovered on genetic diagnosis affect prognosis of certain sarcomas? (4) Which sarcoma translocations can benefit from an improved response and outcome using existing and forthcoming pharmacogenetic approaches targeting molecular events? This review summarizes recent advances in molecular genetics that are available and will soon be available to clinicians to better predict outcomes and subsequently help make future treatment decisions. Level of Evidence: Level IV, diagnostic study. See the Guidelines for Authors for a complete description of levels of evidence.
Article: Local irradiation in combination with bevacizumab enhances radiation control of bone destruction and cancer-induced pain in a model of bone metastases[Show abstract] [Hide abstract]
ABSTRACT: Skeletal metastases are a major source of morbidity for cancer patients. The purpose of this study was to evaluate the effects of megavoltage irradiation and antiangiogenic therapy on metastatic bone cancer. A tumor xenograft model was prepared in C3H/Scid mice using 4T1 murine breast carcinoma cells. Twenty-eight mice bearing tumors were treated with either bevacizumab (15 mg/kg), local megavoltage irradiation (30 Gy in 1 fraction), combination of bevacizumab and local megavoltage irradiation or physiologic saline solution (control group). Tumor area, bone destruction, tumor microvessel density, pain-associated behaviors and expression of substance P were assessed. Combined modality treatment reduced the frequency of pain-associated behaviors, decreased levels of nociceptive protein expression in the spinal cord, maintained cortical integrity and decreased the density of microvessels as compared to single modality treatments. We conclude that concurrent antiangiogenic therapy and localized radiotherapy for the treatment of bone metastases warrants further evaluation in human clinical trials.
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ABSTRACT: 2-Methoxyestradiol (2ME(2)), a physiologic metabolite of 17beta-estradiol (estrogen), has emerged as a promising cancer therapy because of its potent growth-inhibitory and proapoptotic effects on both endothelial and tumor cells. 2ME(2) also suppresses osteoclast differentiation and induces apoptosis of mature osteoclasts, and has been shown to effectively repress bone loss in an animal model of postmenopausal osteoporosis. Given these observations, we have examined whether 2ME(2) could effectively target metastasis to bone, osteolytic tumors, and soft tissue tumors. A 4T1 murine metastatic breast cancer cell line was generated that stably expressed Far Red fluorescence protein (4T1/Red) to visualize tumor development and metastasis to bone. In an intervention study, 4T1/Red cells were injected into bone marrow of the left femur and the mammary pad. In the latter study, 2ME(2) (10, 25, and 50 mg/kg/d) treatment began on the same day as surgery and was continued for the 16-day duration of study. Tumor cell growth and metastasis to bone were monitored and bone volume was determined by micro-computed tomography. 2ME(2) inhibited tumor growth in soft tissue, metastasis to bone, osteolysis, and tumor growth in bone, with maximum effects at 50 mg/kg/d. Furthermore, tumor-induced osteolysis was significantly reduced in mice receiving 2ME(2). In vitro, 2ME(2) repressed osteoclast number by inducing apoptosis of osteoclast precursors as well as mature osteoclasts. Our data support the conclusion that 2ME(2) could be an important new therapy in the arsenal to fight metastatic breast cancer.
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ABSTRACT: The best treatment for intramuscular hemangiomas is unclear in part because the outcome is variable, with recurrence rates ranging from 18% to 61%. This variance is due to deficiencies in previous reports such as an inadequate population size, lack of life table analyses, lack of uniform pathologic criteria, and loose or absent definition of surgical margins. Our goal was to address these deficiencies and support or refute previous results. We identified 110 patients between 1981 and 2005. There were 48 males and 62 females with an average age of 22 years at the time of consult. Kaplan-Meier analysis showed 76% of patients managed initially without excision were surgery-free at 2 years and 66% at 5 years. For patients treated with surgery, 86% and 73% were recurrence free at 2 and 5 years, respectively. There were substantial differences in local recurrence when stratified by margin: 93% of patients were recurrence free at 5 years when the excision was marginal and wide, 65% when intralesional without any gross remaining tumor, and 33% when intralesional with gross remaining tumor. Surgical margins and tumor size were the only identified risk factors for recurrence.
Article: Forearm Mass in an Adolescent
Article: Biology of Bone Cancer Pain[Show abstract] [Hide abstract]
ABSTRACT: Bone cancer pain is a devastating manifestation of metastatic cancer. Unfortunately, current therapies can be ineffective, and when they are effective, the duration of the patient's survival typically exceeds the duration of pain relief. New, mechanistically based therapies are desperately needed. Study of experimental animal models has provided insight into the mechanisms that drive bone cancer pain and provides an opportunity for developing targeted therapies. Mechanisms that drive bone cancer pain include tumor-directed osteoclast-mediated osteolysis, tumor cells themselves, tumor-induced nerve injury, stimulation of transient receptor potential vanilloid type 1 ion channel, endothelin A, and host cell production of nerve growth factor. Current and future therapies include external beam radiation, osteoclast-targeted inhibiting agents, anti-inflammatory drugs, transient receptor potential vanilloid type 1 antagonists, and antibody therapies that target nerve growth factor or tumor angiogenesis. It is likely that a combination of these therapies will be superior to any one therapy alone.
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ABSTRACT: Primary and metastatic bone cancers are difficult to eradicate and novel approaches are needed to improve treatment and extend life. As bone cancer grows, osteoclasts, the principal bone-resorbing cells of the body, are recruited to and activated at sites of cancer. In this investigation, we determined if osteoclast lineage cells could function as a cell-based gene delivery system to bone cancers. We used the cytosine deaminase (CD) 5-fluorocytosine (5-FC) enzyme/prodrug system and studied bone marrow and bones from transgenic mice expressing a novel CD gene regulated by the osteoclast tartrate-resistant acid phosphatase (TRAP) gene promoter (Tg/NCD). DsRed2-labeled 2472 sarcoma cells were placed in Tg/NCD osteoclastogenic cultures and treated with 5-FC. 5-FC treatment resulted in profound bystander killing (90%; P < 0.05). The effect of 5-FC treatment on osteoclast lineage cells was most dramatic when administered at the beginning of the 7-day cultures, suggesting that mature osteoclasts are less sensitive to 5-FC. Evaluation of osteoclast-directed bystander killing in vivo revealed dramatic killing of bone cancer with only a modest effect on osteoclast number. Specifically, 5-FC treatment of tumor-bearing Tg/NCD mice or Tg/NCD bone marrow transplanted C3H mice (Tg/NCD-C3H) resulted in 92% and 44% reductions in tumor area, respectively (P < 0.05). Eight of ten 5-FC-treated Tg/NCD mice had complete bone tumor killing and five of six 5-FC-treated Tg/NCD-C3H mice had reduced tumor compared with controls. In addition, Tg/NCD osteoclasts were resistant to 5-FC treatment in vivo, a very important feature, as it identifies osteoclasts as an ideal CD gene delivery system.
Article: Advances in Treating Metastatic Bone Cancer: Summary Statement for the First Cambridge Conference[Show abstract] [Hide abstract]
ABSTRACT: The First Cambridge Conference on Advances in Treating Metastatic Bone Cancer, a symposium held in Cambridge, Massachusetts, October 28 to 29, 2005, was convened to discuss recent advances and research related to the natural history of bone metastases and skeletal complications, bone cancer biology, treatment of myeloma and other solid tumors, and treatment-induced bone loss. The conference format combined brief presentations with extended periods of discussion. The conclusions reached during the 2-day meeting are summarized in this article and presented in more detail in the individual articles and accompanying discussion sessions that comprise the conference proceedings.
Article: Novel Cytosine Deaminase Fusion Gene Enhances the Effect of Radiation on Breast Cancer in Bone by Reducing Tumor Burden, Osteolysis, and Skeletal Fracture[Show abstract] [Hide abstract]
ABSTRACT: Painful breast carcinoma metastases in bone are a common manifestation of malignant disease. Eradication of these tumors can be evasive, and as a result, skeletal morbidity increases with disease progression. The treatment potential of cytosine deaminase (CD) gene therapy combined with radiation treatment was evaluated in vitro and in vivo using a 4T1 murine breast carcinoma model. 4T1 carcinoma cells were transduced with a fusion gene encoding the extracellular and transmembrane domains of the human nerve growth factor receptor and the cytoplasmic portion of the yeast CD gene (NGFR-CD(y)). CD-expressing tumor cells (4TCD(y)) were highly sensitive to treatment by 5-fluorocytosine prodrug (P < 0.0001). 5-Fluorocytosine treatment of 4TCD(y), but not 4T1 cells, enhanced the effects of radiation in vitro (P < 0.0001). 5-Fluorocytosine prodrug treatment also increased the therapeutic potential of radiation in vivo. Mice with 4TCD(y) intrafemoral tumors showed increased effectiveness of radiation based on improved reductions in tumor size, reductions in tumorigenic osteolysis, and a decrease in skeletal fractures (P < 0.01).
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ABSTRACT: Osteoclasts play a seminal role in many skeletal diseases and therefore are candidates for cell-based gene delivery systems to treat disorders of bone. As an initial step toward developing osteoclast-mediated gene delivery systems, we have made and analyzed a customized Molony-Murine leukemia virus (MMLV)-based retroviral vector containing elements of the osteoclast-specific tartrate-resistant acid phosphatase (TRAP) gene. RAW 264.7 cells were transduced with the customized vector (E3) and differentiated along macrophage or osteoclast lineages. E3 contained a truncated form of the human nerve growth factor receptor (NGFR) as a reporter gene. NGFR expression increased with RANK-ligand (RANK-L) treatment but not with macrophage (gamma-IFN/LPS treatment) differentiation. Enhanced NGFR expression peaked 48 h after RANK-L treatment. Electrophoretic mobility shift assays (EMSA) analysis of the TRAP gene regulatory elements in E3 identified a single 27 bp DNA probe, which specifically bound protein from RANK-L-treated cells. DNA sequence revealed AP-1 binding sites, and analysis with mutant probes implied that the sites were functional. EMSA supershift analysis identified Fos protein interacting with the 27 bp probe. In summary, insertion of sequence -962 to -868 from the TRAP gene into the U3 region of the MMLV LTR confers RANK-L induced retroviral gene expression via Fos family protein interaction at AP-1 sites.
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ABSTRACT: Cytosine deaminase (CD) catalyzes the deamination of 5-fluorocytosine (5FC) to produce the highly toxic chemotherapeutic agent 5-fluorouracil (5FU). A unique feature of the CD/5FC enzyme/prodrug system is its ability to kill adjacent cells via bystander killing. Bystander killing of cancer cells can be mediated by non-cancerous accessory cells transduced with the CD gene; one type of non-cancerous accessory cell found in primary bone cancer and breast cancer metastases to bone is the osteoclast. This manuscript determines if osteoclast precursor cells, transduced with the CD gene, can function as a gene delivery system capable of killing cancer cells. An osteoclast precursor cell line (RAW 264.7, RAW) and authentic bone marrow-derived osteoclast precursor cells were transduced with a retroviral vector containing the cytosine deaminase fusion gene (NCD) composed of the human nerve growth factor receptor and CD genes. RAW cells and bone marrow-derived osteoclast precursor cells transduced with NCD expressed NCD protein and converted 5FC to 5FU. Treatment of NCD-transduced osteoclast precursor cells with the 5FC prodrug resulted in significant killing in vitro. NCD-transduced osteoclasts were co-cultured with either DsRed2-labeled sarcoma cells (2472-DSR) or green fluorescent protein (GFP)-labeled breast cancer cells (GFP-4T1). Treatment of the NCD osteoclast/tumor cell co-cultures with 5FC resulted in bystander killing of 2472-DSR cells (P < 0.006) and GFP-4T1 cells (P < 0.004). These findings demonstrate that NCD-transduced osteoclasts can promote killing of cancer cells and introduce the exciting possibility for developing osteoclast-mediated, CD-based treatment of primary bone cancers and breast cancer metastases to bone.
Top Journals
University of Minnesota Duluth
Duluth, Minnesota, United States
- • Laboratory Medicine and Pathology
- • Medical School
University of Minnesota Twin Cities
Minneapolis, Minnesota, United States
- Department of Orthopaedic Surgery

subset: commoncrawl


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Price: $
Age: 19-24
Skin: Very Oily, Fair-Medium, Not Sure
Hair: Brunette, Other, Other
Eyes: Other
i hated this mascara, it clumped all of my lashes together and..... well it made my lashes to long with absolutly no volume. This was on of the worst mascaras i have ever used
Age: 25-29
Skin: Combination, Tan, Neutral
Hair: Black, Other, Other
Eyes: Brown
*Smooth Wet Look
*Easy Application
*Feathery/Fan Look
*Length was decent
*No Drama (if you prefer it)
*2 Coats was the limit
*No thickening
This was a great natural look but nothing special. By the end of the day my lashes had fallen and looked like I had none at all. It was a cheap BOGO deal when I got it. But I got what I paid for.
pic: http://1.bp.blogspot.com/_v65LTxA3Cvo/TEybBXHFBcI/AAAAAAAABGg/heMhAewr3Ik/s200/rimmel+superlash.jpg
Age: 25-29
Skin: Combination, Medium, Warm
Hair: Brunette, Straight, Medium
Eyes: Hazel
So I strayed from my HG mascara (CG LashBlast volume) and ventured to try a new mascara. Although it was less than $3.00 I'm very surprised at how great of a mascara it is. The formula is dry (which I like) and separates my lashes but adds volume too. It's also easy to build volume with a couple coats.
The brush is cone-shaped and works well on my lashes.
The only thing I didn't care for was that it flakes when applying, but no other time during the day. I often have to 'clean-up' my eyelids after applying this, no matter how careful I try to be.
I will definately be buying this again!!!
Age: 30-35
Skin: Sensitive, Fair, Cool
Hair: Other, Wavy, Medium
Eyes: Green
I state that I would buy this again, but I'm not entirely sure. But I wouldn't rule it out - so I didn't want to put "no". Like many reviewers have stated, this is a good everyday kind of mascara. It separates and lengthens, does an OK job with volume, but nothing special. This is a nice true black, but not inky black if that's what you are looking for.
The price is right for this - I got a 2 pack at Walmart for under $5. This mascara might work best in tandem with another mascara for holding curl and volumizing.
EDIT: am changing my verdict on this. this is so average and basic in every way. it does a good job of separating, but that is about it.
Age: 19-24
Skin: Combination, Fair-Medium, Not Sure
Hair: Black, Other, Other
Eyes: Brown
Well i love this product. it makes my eye lashes look curly and longer.ps if you want a natural look, apply only one coat.
Age: 30-35
Skin: Combination, Fair-Medium, Warm
Hair: Brown, Wavy, Medium
Eyes: Other
I dont have a staple mascara and I am not going to choose 1 of many boutique favorites because I end up tossing them after they expire.
There is not 1 mascara I have used twice. I picked up Rimmels Extra Super Lash Mascara.
I'm impressed. My eyes are usually sensitive and this mascara doesn't bother them. My next purchase was going to be Clinique for a mall haul. I can put it off because this is gentle enough.The only cons are that it doesn't hold curl very well. The look of curled black and bold lashes is the look I always try to maintain. Curl will last 10 minutes and then the lashes become weighed down. I separate the lashes as formula quickly drys and maintains very black. Its very easy to remove. The brush is an old fashioned wand most woman still would keep in all mascaras if they were given a choice so that's a bonus.
This is a great mascara and performs really well. Will I stick with
it? I don't know yet. Would I suggest it? Yes, I would.
Age: 30-35
Skin: Acne-prone, Fair-Medium, Not Sure
Hair: Brown, Wavy, Fine
Eyes: Brown
I think this is a fantastic mascara. It goes on smooth and clump free, doesn't smear or smudge, hardly ever flakes, and doesn't irritate my eyes (I wear contacts). Adds nice length and builds some volume, too. All with just 2 quick coats. It also makes my lashes look like they have a bit of a curl to them, and I never bother to curl my lashes. Gives me a nice, open, wide-eyed look at a wonderfully cheap price. Very nice!
Age: 25-29
Skin: Acne-prone, Fair-Medium, Not Sure
Hair: Blond, Curly, Medium
Eyes: Hazel
Great mascara. I bought this a while ago and loved it. Just bought it a few days ago as it was on sale for $6 ! Can't go wrong with this budget beauty tool. The brush grabs each lash and coats them in black mascara. It bIuilds beautifully and gives super length for me. Just need to use a lash comb after to comb out some of the spider web tangles. Rimmel is a great brand for the babe on a budget !
Age: 19-24
Skin: Dry, Fair, Cool
Hair: Black, Wavy, Fine
Eyes: Hazel
I congratulate Rimmel on such a nice budget mascara.
I bought this a while ago because I ran out of my usual mascara and I've kept coming back to this ever since. It doesn't clump your lashes together which I really like in a mascara.Makes my lashes look really defined and adds a okay amount of volume for day-to-day use.
I use this mascara every day now
Really good for the price.
Age: 18 & Under
Skin: Combination, Fair-Medium, Warm
Hair: Brunette, Straight, Medium
Eyes: Brown
I heard a lot of great things about this product, but i had no luck with it. I have quite thick long lashes and use mascara for an extra touch but this really didnt do much for them. It gave me more length but no volume, which isnt what id prefer. Plus because its so inexpensive. I guess i could probably use this with another mascara...
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Kuala Lumpur International Airport, Kuala Lumpur – Malaysia
The Only Introduction is of Airport
Kuala Lumpur International Airport is the 5th busiest international airport in Asia. It is located in Sepang state and holds 35 million passengers along with 1.2 million tonnes of cargo, on an annual basis. It has three terminal under the names of Main Terminal, Satellite Terminal and Low Cost Carrier Terminal (LCCT). Main Terminal serves both international and domestic flights whereas Satellite terminal provides services solely for international passengers. LCCT is a temporary terminal designed to cater with the requirements of low budget airlines.
Passengers Information
Tourists should acquire visa requirements from their Malaysian Embassy located in their respective countries. It is because, its requirements depends upon the nationality an individual possess. On the other hand, all arriving passengers are required to pass through the arrival concourse located at level 3. Departure level is located on level 5 where departing passengers, holding boarding passes will only be allowed to enter departure lounges. However, all departure passengers should make sure that they arrive at the departure lounge 30 minutes prior to their departing time.
Services and Facilities
Kuala Lumpur International Airport Authorities have ensured tourist convenience by providing all necessary services and facilities on its premises. Hotels are available on Main Terminal and Satellite Terminal to provide accommodation facilities. There are numerous snack bars, fast food chains, restaurants and shops available to cater with all essential requirements except on Low Cost Carrier Terminal which lacks tourist facilities development. Police Authorities can be informed at +60(0)3 8787 2222 in case of baggage loss. However, there are luggage safes available on Satellite Terminal to temporarily store travelers belongings.
Nearby Places of 'Kuala Lumpur International Airport'
There are several sights available near the Airport Facility:
- PETRONAS is a Malaysian Oil and Gas Company which was founded on August 17, 1974. It primarily serves fuel requirements for all transport vehicles.
- Malaysian Grand Prix offers an highly entertaining racing experience for all individuals.
- Malaysian Aviation Academy provides courses that train individuals with technical skills and Aviation Management.
- Kuala Lumpur International Airport-tourism Centre provides a platform of all necessary information for tourists.
TripAdvisor and Physical Tourists
There is some forum discussion about the Airport, which is mentioned here to know some kind of suggestions on physical tourists' behalf:
Maic, a Reviewer answered about the Airport as just, "Just take an airport limo. There are ticket counters just after you pass customs. Do not patronize touts who pester you for taxi services. Depending on what time you get out after baggage claim, you might get a mid night surcharge."
AlexMcca, a Reviewer answered about the Airport as just, "There is no swimming pool in Airside Transit Hotel, so you need to go to Pan Pacific Hotel for the unlimited use of its 24 hours health club facility which includes swimming pool for RM 26 per person."
Let My Virtual Experience Go
I worked hard to convince my parents for a family tour to Kuala Lumpur in our winter holidays. It is mainly because, I have heard so much about this beautiful city which compels me to experience its spectacular views with my own eyes. My hard work did pay off when my father confirmed our airline and hotel reservations there. I have planned everything to make this visit quite memorable.
After leaving the Kuala Lumpur International Airport, I have visited many tourist sights in Kuala Lumpur Architectural, Cultural. The most thrilling experience was in Malaysian Grand Prix where drivers were fighting hard for their destinies. The surrounding air was filled with an immense sense of excitement with people roaring and hooting for their favorite drivers. Meanwhile. I also visited Dewan Filharmonik where I listened to the most beautiful orchestra. Everything was perfect to acquire best possible musical experience there.
I found this salient city more than my expectations. There have been highly appropriate developments by Government Authorities across the city. It also holds lovely sights for tourists which reflects a visual demonstration of heaven on earth. I would recommend everyone to surely give a visit to Kuala Lumpur which would make them realize about Malaysian culture besides gaining lots of excitement.
Sophia Cook
Latest posts by Sophia Cook (see all)
- Lets Go Sago: Boracay Island Is Condsidered The World's Best - February 22, 2014
- Ayubia Chairlift Can Be Fun And a Super View - October 30, 2013
- Kaghan Valley – Every Single Attraction is Spectacular - October 27, 2013


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A little background- my LO's reflux is pretty well controlled on Prevacid, but she still struggles with gas/upset tummy. I EBF and am dairy free for her (she is 6 months old). I talked to our pedi and decided to try one day off the Prevacid to see if it was causing the gas.
That went well until that night. She startes sptting up more, hiccuping a lot, wet burps and that night was really rough. I decided she still needed the Prevacid and have given it to her the past two days. However, he reflux seems worse still. Could this be from Acid Rebound from the missed dose?
Also, how do I tell when gas is uncontrolled reflux vs. side effect of Prevacid?
If she seems happy, sleeps a decent amount, but won't put herself to sleep most times (seems uncomfortable), does that mean the refux isn't well controlled? I want her on the smallest dose that is effective. but don't want her to be uncomfortable.
Sorry for the book!


text:
Kotaku - On the third floor of Nintendo's U.S. headquarters, next to the conference rooms named after Mario and Donkey Kong, there's a door that you can't open. There's no boss key or warp pipe here—unless you're one of the handful of people with a high-security keycard, you're not getting in.P
If you were to somehow break the seal, you might uncover a treasure trove of Nintendo secrets—scripts and code belonging to unannounced games from the most iconic video game franchises in the world. Maybe you'd stumble upon the Wii U version of Zelda, unfinished and unpolished. Maybe you'd find some hardware revision that hasn't been unveiled yet. Maybe you'd run into one of the talented writers responsible for many of Nintendo's most memorable moments.


text:
Many Volunteers must step up in Tennessee's title defense
Updated: March 18, 2008, 7:13 PM ETBy Mechelle Voepel | Special to ESPN.com
It seems Candace Parker typically has only "now" and "the next thing" on her mind. A game ends, and she dissects her performance with an air of distraction. Because what's already over is never going to get her full attention. What she has to do at the moment and what's coming up are what matter to her.But it's instructive for us to look back a little in order to gauge what we could see from Parker and defending national champion Tennessee in the Big Dance. ...
Read full story
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2008 NCAA Women's Basketball Tournament
Tournament Index
Elite Eight• Dish: Tampa, here we come!
• Hays: Gutsy win gets UConn seniors to Final Four
• Voepel: Tough Tennessee wills itself to Tampa
• Dish: Losses by Maryland, UNC leave ACC empty
• Voepel: LSU the toast of New Orleans
• Miller: Second really is the best in Spokane
• Voepel: Elite Eight loss toughest on the seniors
• Hays: Second chances key to UConn-Rutgers
• Voepel: Like CP3, Hornbuckle important to Vols
• Voepel: LSU faces toughest Elite foe yet in UNC
• Miller: Terps, Cardinal feel slighted in Spokane
Sweet 16• Dish: Welcome to the Party, Texas A&M
• Hays: Knights not satisfied with win
• Hays: Hobbled Hunter finds ways to help Huskies
• Voepel: UNC overcomes slow start for comeback
• Voepel: White-Riley better than LSU-OK State
• Voepel: Black back, driving force for Blue Devils
• Hays: GW's Beck's must break out of slump
• ESPN.com experts' Sweet 16 picks
• Voepel: Overlooked Dores could test Terps
• Voepel: Talent-laden Louisville ready for UNC
• Hays: Louisville's Walz a real statement maker
• Voepel: Oklahoma City Regional
• Hays: Greensboro Regional breakdown
• Creme: Spokane Regional breakdown
• Mowins: New Orleans Regional breakdown
• Merrill: The meeting that saved Texas A&M
First two rounds• Tuesday's Tournament Dish: Big East flavor
• Hays: Awe-inspiring Allen leads Irish to OT win
• Voepel: Moore so good we're left wanting more
• Hays: Defending champs get defensive
• Monday's Tournament Dish: Cowgirls up!
• Hays: Irish guards hope to offset OU posts
• Voepel: Huskies vs. Horns? Try Geno vs. Gail
• Sunday's Tournament Dish: First-round wrap
• Voepel: Unusual suspects step up for UConn
• Hays: Not always pretty, but OU finds way to win
• Saturday's Tournament Dish: Typical Day One
• Mowins: Florida State too quick for Ohio State
• Voepel: Buckeyes make another early exit
• Voepel: Coach G, Horns feeling litte pressure
• Hays: Sibling act helps Utah prepare for Purdue
• Voepel: New tournament, same favorites
• Hays: Five underrated players to watch
• Smith: The storied saga of Geno and Pat
• Hays: UConn's Moore playing beyond her years
• Previews: G'boro | N.O. | Okla. City | Spokane
• Voepel: Calling all Volunteers
• Voepel: Big Easy? Not for Heels
• Hays: Bracket's big questions
• Creme: Good bracket with a few exceptions
• Hays: Magnificent seven on inside track
• ESPN.com experts break down the bracket
• Merrill: OU, Paris seeking shelter from storm
• Blog: There's nothing like your first tourney


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There is only one road into Denali—92-mile "Park Road"—and private vehicles are not allowed more than 15 miles into the park. For land tours, visitors have the option of tour buses (narrated) and shuttle buses (not narrated with the option to get off and on). Bus service begins around the end of May and continues through the middle of September. Given the large size of Denali National Park and lack of access, fly-over tours also are popular.
Tour Buses (White)
Denali National Park tour buses have a trained naturalist onboard to provide narration and stop for wildlife viewing and restrooms. Passengers must stay with their original bus. Below are the three different bus tours with their turnaround points on Park Road and duration. Fares are round-trip:
Denali History Tour: Mile 17; 4.5 hours; $66.50
Tundra Wilderness Tour: Mile 53; 8 hours; $113.25
Kantishna Experience Tour: Mile 92; 11 hours; $159
For an excellent visual tour of the Denali Park Road and landmarks along the way, Alaska.org has created a Denali Flyover Video.
Shuttle Buses (Green)
Denali shuttles are designed to move people around inside the park. Like tour buses, shuttle buses stop for wildlife viewing and restrooms but there isn't a narrator onboard and passengers can get off and on anywhere along the road. Shuttles are best for those who want to experience the park on their own terms, including day hikers and backpackers.
The schedule for Denali shuttles undergoes slight changes throughout the summer, but the shuttles pass major pick-up points multiple times per day. Fares for shuttle buses are destination-specific and cheaper than tour buses—it's $50 one-way to Kantishna and the end of Park Road.
Fly-Over Tours or "Flightseeing"
Local aviation companies offer Denali National Park fly-over tours or "flightseeing." The planes are small (3–6 seats), single-engine aircrafts that can navigate the tight passes, turbulent weather, and glacier landings required in Denali. Scenic fly-over tours range from 1-hour "South Face" flights ($199) to 2-hour "Grand Denali" flights ($385) with glacier landings. Fly-over tours run year-round depending on the conditions. Below are local aviation companies that service Denali:
Talkeetna Air (Talkeetna)
K2 Aviation (Talkeetna)
Sheldon Air Service (Talkeetna)
Fly Denali (Talkeetna and Healy)
Rust's Flying Service (Anchorage)


text:
Preventing Stroke With Vitamin C
…But vitamin C is critical to heart health—preventing coronary artery disease and strengthening the blood vessel walls. Plus, now a new study suggests that having a vitamin C level that's too low may increase your risk factors for stroke—or, more specifically, a hemorrhagic stroke. The primary French…Read More


text:
- When is the last time you went for a really long walk? Just went into the bush and walked? This program is the story of a big walk organised to encourage families to get out on-country and gather bush foods, as an antidote to the perils of modern community life. People from Kintore, Mt Liebig, Papunya ...Tuesday 9 December 2014
- Alice Springs traditional owners are voicing their anger about the disconnection of water to Whitegate but a sustainable solution seems out of reach....Tuesday 16 September 2014
- When is the last time you went for a really long walk? Just went into the bush and walked? This program is the story of a big walk organised to encourage families to get out on-country and gather bush foods, as an antidote to the perils of modern community life. People from Kintore, Mt Liebig, Papunya ...Tuesday 8 July 2014
- Traditional owners who have opposed a nuclear waste dump on Muckaty Station in the Northern Territory say they had no interest in a $12 million compensation package offered by the Commonwealth....Wednesday 11 June 2014
- A high profile Indigenous cultural exhibition is set to open in Adelaide this evening despite its earlier postponement over a cultural dispute....Monday 31 March 2014
- A group of elders in the Central Australian community of Yuendumu are working hard to create positive changes for their people...Thursday 30 May 2013
- The Tangentyere Council says comments made about Alice Springs town camps by the Minister for Indigenous Advancement have stigmatised residents....Friday 25 January 2013
- Becoming a leader and standing up against racism...Tuesday 11 December 2012
- Residents of the Indigenous community of Utopia in the Northern Territory say feral horse numbers need to be reduced as they are damaging vital infrastructure....Thursday 15 November 2012
- An Native American woman from a reservation in the United States has arrived in Central Australia to exchange knowledge with local Indigenous groups....Friday 9 November 2012
- In the new film Coniston, David Batty and co-writer and co-director Francis Jupurrurla Kelly have retold one of the darkest chapters in Australias history - the Coniston massacre. Through a combination of survivors' and their descendants' testimonies and stunningly realised dramatic ...Friday 3 August 2012
- A remote Northern Territory cattle station remains in the spotlight as the fight against a national nuclear waste storage facility enters its sixth year...Sunday 27 May 2012
- A leading Indigenous research institute has suspended its $700,000 grants program....Monday 23 January 2012
- Former Northern Territory Labor Minister Alison Anderson insists no deals have been done with the Opposition Country Liberals in exchange for her support....Thursday 8 September 2011
- Federal Minister for Indigenous Affairs Jenny Macklin is in the Centre for a series of community consultations about the future of the Federal intervention. ...Thursday 21 July 2011
- South Australia's Aboriginal Affairs Minister says a group of Yuendumu residents living at a campsite in Adelaide's parklands are "holidaying" and should go home. ...Monday 7 March 2011
- Mediation talks between family groups in the remote Northern Territory community of Yuendumu are in limbo again, with some residents deciding to return to South Australia....Tuesday 4 January 2011
- The company engaged to complete Alice Springs' $100 million Indigenous housing program says it's screaming out for trades people. But Alice Springs tradies say they're willing and able, but are losing out to interstate businesses....Thursday 4 November 2010
- Legendary Country Music singer and Aboriginal leader, Gus Williams OAM, was today farewelled at a state funeral in Hermannsburg....Friday 1 October 2010
- We all have those moments of craning our head towards the night sky, checking it out, in awe, wondering what's out there, trying to figure it all out and how it affects life on Earth. But have you ever wondered who may have looked up at the skies first? The ancient Greeks, Galileo, the Egyptians or could ...Friday 17 September 2010
- Alice Springs found itself in the national news again last night when Lateline screened a story on the 'rivers of grog' that continue to wreak havoc in the centre. What did locals have to say?...Thursday 19 August 2010
- An Alice Springs pastor is calling for change to Northern Territory alcohol laws to cut what he says is ongoing carnage. "We have like a mass euthanasia happening with people making huge profits, retailing to people substances that are killing them," he said. ...Thursday 19 August 2010
Explore by Topic
Latest Indigenous Other Peoples stories on ABC Alice Springs
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- NT pastoralist Steven Cadzow sold 178 heifers at Tamworth, 94 of those were purchased by John Hurley from Wallabadah.
- Managing director of ABM Resouces, Brett Lambert, explains why the Old Pirate mine will close in April.
- The only mango grower in Central Australia, John Crayford, said there was a bit of a rush on over the weekend at the only place he sells his mangoes.
- Representatives from Sino-Australia Top Beef, an online seller of Australian beef to the Chinese market, have visited Central Australian cattle statio
- Speaking through interpreter Ms Vivian Zhang, Sino-Australia Top Beefs Chairman Mr Zhang Yong says they sold 4000 tonnes of Australian beef last year


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Fuga dal labirinto [ 1994 ] by compictorWatch
©2012-2016 compictor
Traditional painting on wooden board
Daily DeviationGiven 2012-09-29
"Look! The Winged Victory of Samothrace!"
Fuga dal labirinto [ 1994 ], stunningly painted on wood by ~compictor. ( Suggested by TinyWild and Featured by SRaffa )
Fuga dal labirinto [ 1994 ], stunningly painted on wood by ~compictor. ( Suggested by TinyWild and Featured by SRaffa )
I love mazes! The style and sense of distance is wonderful!
i love this emptiness and sublimity
wow wow
I just been to Paris... Went to the Louvre and saw the Winged Victory... Amazing statue. I love the way you pictured it. Great work!
Kudos to the DD poster: a "Bored of the Rings" reference! 7@=e
so majestic and mildly breathtaking
i dont know why but this picture is so deep and mysterious it gave me the chills
Love this
this seems to express a deep philosophyical issue.
Holy crap, This is awesome..!!!
Beautiful work, Ivanoe, very mesmerizing, I can almost hear the wind blowing in those heights over the endless maze
This is excellent I like that the sbject is so simple yet the details are so intricate. No wonder this got a Daily Deviation.
Very Impressive!!!!
What a wonderful idea, this is magnificent. It seems to me that a lot of surrealism works appear to be missing some aura of emotion and idea but this is purely amazing! Incredible work!
A sea of mazes...
Wow amazing work!
Unusual, but AWESOME!!
deus ex machina?
I think it wants to say that even if we go and steal back the "Niki of Samothraki" sculpture from Luvre, we have to get out of a pretty difficult situation explaining how the hell, suddenly, it is in the Acropolis museum!!!!!
Great job! I love the lighting and the whole tecnic! Bravo!
Great job! I love the lighting and the whole tecnic! Bravo!
Don't blink!
*coughs* Anyway, this is an amazing painting!
*coughs* Anyway, this is an amazing painting!
wow amazing job!
@Dreamer - I think confusion is the point. Why else draw a maze if you intend to invoke something concrete, thematically speaking? It is a wonderful piece though. Good work, Compictor.
...this is stunning... the color scheme is wonderful.
However..i can't decide what to think about it
However..i can't decide what to think about it
What does it mean?
My fisrt thought: Hey, look! It's a Weeping Angel...with no head!
My second thought: Oh my word... This is... Stunning...
My second thought: Oh my word... This is... Stunning...
what is it?
Why you choosed a title in italian? Is that an homage to the Metaphisics movement? Because the atmosphere here reminds me the one seen in De Chirico and Carrà's paintings...
omg wow
You were very bored, right?
Very nice!
Very nice!
headless weeping angel! no jk this is really pretty c:
That's what I thought
Though, I did just watch the newest episode that had weeping angels in it
Though, I did just watch the newest episode that had weeping angels in it
totalmente increible!!!
Ah! So that's how you get through the maze!
freaking epic
i saw this in person and it was amazing
bring that back!! greetings from Greece! ^_^
kuv this its dreamy
Congratulations...this is a very interesting painting, the technique is vibrating. We can feel the little strokes of the paintbrush all over but without making it feels to impressionism. The concept is great too...