text:
NASHVILLE, Tenn. (AP) -- Belmont University officials say the school has been chosen as one of three sites to host a presidential debate next year.
The October 7th event will be use a "town hall" format with the audience proposing questions directly to the candidates. It is expected to be viewed by millions worldwide.
This will be the first time presidential candidates have debated in Tennessee since the Commission on Presidential Debates was established in 1987.
Other debates will be the University of Mississippi in Oxford and Hofstra University in Hempstead, N.Y. Washington University in St. Louis will host the vice presidential debate.
(Copyright 2007 by The Associated Press. All Rights Reserved.)


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One more thought on T Day, from one of the greatest songwriters of all time.
One more thought on T Day, from one of the greatest songwriters of all time.
Libertarians tend to be self-reliant individualists. That may be what I like most about Libertarians. It may also be what keeps us a small minority. We prefer to keep the power to decide for ourselves and provide for ourselves. Libertarian blogger
Happy Thanksgiving all! Today is the day we don't count calories or watch portion sizes in our house.
A day of food, football and dogs. What could be better?
Hihope Hiland Heathen of Perth CD, RE, CGC, TDI
I'm at work today while the other half does the cooking! Not a bad place to be, opening day at the prettiest ski resort in the west Happy Thanksgiving to all of you.
Owned and handled by Cruisin' with Indiana Jones, JH
Alternate Handler: Westwind Buffalo Soldier
Apprentice Handler: Snake River Medicine Man, SH

subset: commoncrawl


text:
Definition of paper cup in English:
A disposable cup made of thin cardboard.
Example sentences
- What you are looking at is a machine that gives you coffee in a little paper cup.
- Vivian forced down the last swallow of cafeteria coffee, tossed the paper cup into the trashcan, and then headed back to Jeremy's room.
- I looked over and noticed the coffee shop door opening and Mr. O'Connor walking out, a paper cup of coffee steaming in his hand.
Definition of paper cup in:
- US English dictionary
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text:
Last Activity: 05-24-2015 06:41 PM
- User Lists
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- "A Horse without a rider is still a horse but a rider without a horse is only a human" www.matthewssaddlery.com.au
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- ReneeM liked post by Saskia On thread : Aussie/"Crossover" saddles?These saddles are quite popular in Australia at the moment, they're called "halfbreed" saddles, or "swinging fender stocks" and they've been around for a while, although they can differ on how much...Liked On: 08-08-2013, 06:39 AM
Posted On: 08-07-2013, 10:31 PMReneeM liked post by DrumRunner On thread : I just want a saddle. Just one.Stay far far away from the cheap crappy saddles on eBay.. I have a custom KO Trading barrel saddle that I love. It fits both of my horses, awesome quality, and isn't really expensive. I think I paid...Liked On: 05-20-2013, 12:13 AM
Posted On: 05-19-2013, 11:56 PMReneeM liked post by tinyliny On thread : Your ideas for the ideal trail riding saddleHavne't read all the replies, so forgive me if I duplicate. I am not a fan of "in-skirt" rigging. I think having the rigging off the tree is better. I think it allows for freer movement of the...Liked On: 05-03-2013, 08:06 AM
Posted On: 05-02-2013, 01:08 PMReneeM liked post by MiniMom24 On thread : Your ideas for the ideal trail riding saddleI have these on a set of Stirrups (Only the Swivel set and not the Drop Ones). E-ZUP Stirrup Extender (http://www.easyupstirrup.com/tour-homeorder.htm). They attach to any stirrups you have. I...Liked On: 05-03-2013, 08:05 AM
Posted On: 05-02-2013, 12:42 PMReneeM liked post by joseeandjade11 On thread : Horse conformation and saddle fitting help please!Can anyone see the 2 pictures because I can't see them? :SLiked On: 05-02-2013, 04:19 AM
Posted On: 05-01-2013, 10:59 PMShe is/was the queen of endurance saddles. My barn manager bought hers 2 years ago after much back and forth with Ms. Saare for customization. LOL when she got it it had the cotton/fiber type girth...Liked On: 05-02-2013, 04:12 AM
Posted On: 05-01-2013, 08:08 AMSharon Saare saddles are NICE. My barn manager has one and she loves it. Unfortunately, Ms. Saare passed away last year.Liked On: 05-01-2013, 02:54 AM
Posted On: 04-30-2013, 06:44 PMReneeM liked post by flytobecat On thread : Your ideas for the ideal trail riding saddleOne thing I do like about English saddles is the stirrups and cinches are really easy to adjust when you are riding. I'm not sure if you could adjust a western saddle so that you could do the same...Liked On: 04-30-2013, 06:46 AM
Posted On: 04-30-2013, 12:20 AMReneeM liked post by eeo11horse On thread : Buying a new saddleExcuse the dirtiness of the saddle... but anyway I like the color, tooling, and most of all the way this saddle fits me. I think the other saddle I use pushes me too far back. I'm going to try to...Liked On: 04-29-2013, 11:25 PM
Posted On: 04-29-2013, 07:22 PMReneeM liked post by phantomhorse13 On thread : Your ideas for the ideal trail riding saddleI do all my trail riding in an english-type endurance saddle: https://sphotos-b.xx.fbcdn.net/hphotos-snc7/427081_3292810160008_1687412845_n.jpg I personally don't care for a horn, so agree...Liked On: 04-29-2013, 07:01 PM
Posted On: 04-29-2013, 11:08 AMReneeM liked post by bsms On thread : Your ideas for the ideal trail riding saddleThe aluminum stirrups I tried were slick as snot on a doorknob. Hated them. I normally use the four-bar style, Australian stirrups without any pad: ...Liked On: 04-29-2013, 07:01 PM
Posted On: 04-29-2013, 11:43 AMteehee if ur aussie i am to :PLiked On: 04-29-2013, 06:58 PM
Posted On: 04-29-2013, 06:01 AMI forgot to add a pic of my saddle, with the round skirting: http://i1282.photobucket.com/albums/a534/raskrock/FBFF790E-241E-47A1-B83D-51F6901F0570-1564-0000055E4220886A_zpsf50d75fb.jpg Yes, I do...Liked On: 04-29-2013, 12:26 AM
Posted On: 04-28-2013, 09:48 PMSorry that it took so long to get back on this. I wanted to get a pic of our Aussie saddle first:...Liked On: 04-29-2013, 12:26 AM
Posted On: 04-28-2013, 09:41 PM
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LTBIA- My model for Daffy Duck by DaveAlvarezWatch
©2005-2016 DaveAlvarez
When pre-production began I got this extremely GORGEOUS drawings of Bugs, Daffy, Taz and Tweety. They had Eric Goldberg written all over them. They were a dinamic version of the old Clampett and Freleng versions of the characters.
Of course, at the end everyone had to stick to the main model sheet but they were fantastic!
Of course, at the end everyone had to stick to the main model sheet but they were fantastic!
YOU worked on Back in Action? One of my all-time favorite movies?
Who did the character designs for Bugs and Daffy (the designs they ended up using in "Looney Tunes: Back in Action")?
Great drawings of him!
Oh Boy! I Love This! Daffy realy looks like he's been in a Clampett cartoon. I love it when you draw kinda like him. He's my favorite director. Who's yours?
exllcent work on Daffy here
Whoa... He's got such freedom and fluidity to his movements... o___o Awesome!
Cool stuff
Pero si te la rifaste, broder!
VA a los favoritos!
VA a los favoritos!
That's a very cool Daffy pose. It's nice that's refered to the old cartoons styles. Nice work!
P.S. Can i promote this in my blog?
P.S. Can i promote this in my blog?
Daffy has an awesome style! This is Excellent!
How the hell do you do it Dave? Can you give me some hints?
BRILLIANT sketch!
BRILLIANT sketch!
I like it |3
Lively character design.
You lucky dawg!
...excellent work! .. very fluid design... I love the old style... *sigh*
...definite from me..
...excellent work! .. very fluid design... I love the old style... *sigh*
...definite from me..
Holy crap,you're my favorite Looney Tune Comics artist!!
Hehehheh, nice.
Awesome, man
Excellent! That first one is nice and Clampett-y. I always love it when you do the Clampett-version Daffy stuff in the comics.
Thanks Kyle. Joan Hilty was the first editor who gave me permission to use Clampett's Daffy for a story. When Mike de Carlo came to ink it he called Joan and asked her why Daffy looked out-of-model. HE-HE


text: Beautiful Family Session! April 10, 2010 Posted in Debra,Pet Portraits,Portraiture Tags: jupiter portrait photographers,palm beach portrait photgraphers,stuart portrait photographers« Allison and Danny are MARRIED! {palm beach wedding photographer}The Gorgeous Rachel! » no comments Your email is never published or shared. Required fields are marked * Name * Email * Website Comment Back to Top Contact Me Share on Facebook Tweet this Post Email to a Friend


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No Food, No Drinks, No Strollers, No Change: No Wonder US Retail is Tanking
'No service?' ask two irate customers in a cartoon, waiting to be served in a restaurant. 'No shirt! No shoes!' they yell, as they pitch the articles of clothing.
12:12 Aug 15, 2011
Oldest Retailing Store 'Sainsbury' Goes Green
Sainsbury's said its initally aim was to stop sending all UK food waste to landfill by this summer but has now been fast-tracked with plans for the 28 Scottish stores.
07:19 Jan 10, 2011
Daunting Delivery Debacle? Another Reason To Shop Early for the Holidays
As more people shop online delivery services are more critical than ever but all the home delivery companies are cutting back and using more temporary holiday workers. How does this impact service and is it the new Achilles Heel of online shopping.
07:52 Oct 22, 2010
QR Loyalty: The Restaurant Industry's Most Impactful Trend In 2011? Self-Serve Loyalty Programs Via SmartPhone
08:47 Sep 23, 2010
ShaveMate...Simplify your Shaving, Simplify your Life!
The definition of a 'Revolution' is: a sudden, complete, or marked change in something. That's exactly what ShaveMate offers; a complete change in daily shaving to what we believe is an easier and more convenient way.
17:29 Mar 16, 2010
Find your Cupid at Madame Stores
The day will become most memorable for all the Valentines by the latest offering of Madame called the 'Cupid is Stupid' with the forgotten Red as the base of the collection.
09:52 Feb 13, 2010
Panchkula Branded Diamond Jewellery Exhibition
What do you get when you put together diamonds as unique as fingerprints and a store that believes in delivering nothing but the best?
14:15 Jan 10, 2010
Groversons Open One-Stop Lingerie Shop in Mohali
Store will have coordinated sets of fancy bras, panties, slips, camisoles and sports bras. The best of cotton fabric has been used to suit the Indian climatic conditions.
10:31 Dec 26, 2009
Fools and their Money - Secret Shoppers
Secret or Mystery Shopper scams abound, but are there some legitimate business opportunities here? Or they ALL scams?
07:12 Dec 20, 2009
99 Cents Only Stores vs Dollar Tree
Anybody unaware of how far a buck can go hasn't shopped the deep discount kings of the land. Neither of them are spelled W-a-l-m-a-r-t. Both beat the big 'W' prices.
15:18 Dec 4, 2009
Mountain Equipment Co-Op Among Top Green Retailers Worldwide
A Canadian Ryerson University Study of Commercial Activity shows that green retailers are taking a range of actions to lead environmentally friendly initiatives.
10:45 Nov 20, 2009
Main Event Haircutters: Look Like A Winner
Careful attention to detail amid a friendly atmosphere takes time, but excellent results and inexpensive pricing make waiting worthwhile. (You can always play a game of 8 Ball while you wait.)
12:19 Jan 2, 2009
Recession-Proof Valentine's Day Online Spending is Up 8.48%
The U.S. Economy Might Be Shaky; But Valentine's Day Online Spending is Up 8.48%; Consumers are Spending an Average of $142.70 on Their Sweethearts
16:59 Feb 14, 2008
Judyth Piazza and Ray Riccio, Sedgwick & Cedar Where Hip Hop Began
Sedgwick & Cedar is proud to celebrate the pioneering spirit, creativity and the style where Hip Hop began in 1973 at the Sedgwick Avenue & Cedar Park intersection of The Bronx, NYC.
11:39 Jan 10, 2008
Folsom Electric Masterpiece Begins
Taking its name from the nearby Folsom Powerhouse, the Folsom Electric and Power Lighting Co. broke ground Tuesday, at the corner of Sutter Street and Scott Street in Historic Folsom.
09:01 Nov 15, 2007
TrafficMaster Modular Flooring Active Tile are The Perfect Solution
Active Tiles are made of 100% recycled crumb rubber which is ground up tires. Not only is this product environmentally friendly, but it also requires no professional installation.
02:43 Oct 11, 2007
Get '10 Items Or Less' Free
Actor Morgan Freeman has at least 3 items waiting for you without charge, as retail giant Sears sheds old skin after last year's November co-op merge with CBS.
17:37 Jan 14, 2007
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Picture: Emma Watson The National Movie Awards held at the Royal festival Hall - Arrivals London, England - 08.09.08
Harry Potter star Daniel Radcliffe is always happy to meet his male admirers - because he feels "flattered" when gay fans have a crush on him.
The actor has appeared naked onstage in both the West End and Broadway in the play Equus - a role he admits has won him a large following in the gay community.
And he insists the male supporters are a welcome change from his hordes of screaming female fans.
He tells the Daily Beast website: "For a lot of straight guys - and I know Im guilty of it sometimes - when you know a gay guy has a crush on you, it is the most flattering thing."
But the 19-year-old has always been comfortable around homosexual men, crediting his showbusiness upbringing for teaching him tolerance towards other lifestyles.
He adds: "My mum was a casting director and my dad was a literary agent and I was surrounded by gay men from a very young age.
"And I was the only boy in my class at school who had that kind of relationship with gay men. Most of my friends had parents who had proper jobs in banks and law firms so none of them had been exposed to homosexuality in the way I had - as a normal course of things. So they had a rather different attitude toward it than I."


text:
Glazed Sausage Bites Appetizer Recipe
"These tangy meatballs have a deliciously different flavor since they're made with sausage," relates field editor Sue Broyles of Cherokee, Texas.
- 1 pound bulk pork sausage
- 1 egg
- 1/2 cup saltine or butter-flavored cracker crumbs
- 2 tablespoons milk
- 1/2 teaspoon rubbed sage
- 1/2 cup water
- 1/4 cup ketchup
- 2 tablespoons brown sugar
- 1 tablespoon soy sauce
- 1 tablespoon vinegar
- 1. In a bowl, combine the sausage, egg, crumbs, milk and sage; mix well. Shape into 1-in. balls. In a skillet over medium heat, brown meatballs; drain. Combine remaining ingredients; mix well. Add to skillet; bring to a boil. Reduce heat; cover and simmer for 15-20 minutes or until centers of meatballs are no longer pink. Yield: 2 dozen.
Reviews for Glazed Sausage Bites Appetizer
© 2016 RDA Enthusiast Brands, LLC


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Are you R D Wurster?Claim your profile
Publications (158)426.18 Total impact
Article: Characteristics of Single Large-Conductance Ca2+-Activated K+ Channels and Their Regulation of Action Potentials and Excitability in vagal Cardiac Motoneurons.[Show abstract] [Hide abstract]
ABSTRACT: Large-conductance Ca(2+)-activated K(+) channels (BK) regulate action potential (AP) properties and excitability in many central neurons. However, the properties and functional role of BK channels of parasympathetic cardiac motoneurons (PCMNs) in the nucleus ambiguus (NA) have not yet been well characterized. In this study, the tracer X-rhodamine-5 (and 6)-isothiocyanate (XRITC) was injected into the pericardial sac to retrogradely label PCMNs in FVB mice at 7-9 days postnatal. Two days later, XRITC-labeled PCMNs in brain stem slices were identified. Using excised patch single-channel recordings, we identified voltage-gated and Ca(2+)-dependent BK channels in PCMNs. The majority of BK channels exhibited persistent channel opening during voltage holding. These BK channels had a conductance of 237 pS. The channel dwell time increased exponentially as the membrane potential depolarized. Occasionally, some BK channels showed a transient channel opening or fast inactivation. Using whole-cell voltage clamp, we found that BK channel mediated outward currents had both transient and persistent components. Using whole-cell current clamp, we found that application of IBTX increased spike half-width in single APs and trains, and reduced the spike frequency-dependent AP broadening in trains. In addition, BK channel blockade suppressed fast afterhyperpolarization (fAHP) amplitude following APs. Furthermore, BK channel blockade significantly decreased spike frequency and spike frequency adaption (SFA). Collectively, these results demonstrate that PCMNs have BK channels which significantly regulate AP repolarization, fAHP, SFA and spike frequency. We conclude that activation of BK channels underlies one of the mechanisms for facilitation of PCMN excitability.
Article: Hypertrophy of Neurons Within Cardiac Ganglia in Human, Canine, and Rat Heart Failure: The Potential Role of Nerve Growth Factor[Show abstract] [Hide abstract]
ABSTRACT: Autonomic imbalances including parasympathetic withdrawal and sympathetic overactivity are cardinal features of heart failure regardless of etiology; however, mechanisms underlying these imbalances remain unknown. Animal model studies of heart and visceral organ hypertrophy predict that nerve growth factor levels should be elevated in heart failure; whether this is so in human heart failure, though, remains unclear. We tested the hypotheses that neurons in cardiac ganglia are hypertrophied in human, canine, and rat heart failure and that nerve growth factor, which we hypothesize is elevated in the failing heart, contributes to this neuronal hypertrophy. Somal morphology of neurons from human (579.54±14.34 versus 327.45±9.17 μm(2); P<0.01) and canine hearts (767.80±18.37 versus 650.23±9.84 μm(2); P<0.01) failing secondary to ischemia and neurons from spontaneously hypertensive rat hearts (327.98±3.15 versus 271.29±2.79 μm(2); P<0.01) failing secondary to hypertension reveal significant hypertrophy of neurons in cardiac ganglia compared with controls. Western blot analysis shows that nerve growth factor levels in the explanted, failing human heart are 250% greater than levels in healthy donor hearts. Neurons from cardiac ganglia cultured with nerve growth factor are significantly larger and have greater dendritic arborization than neurons in control cultures. Hypertrophied neurons are significantly less excitable than smaller ones; thus, hypertrophy of vagal postganglionic neurons in cardiac ganglia would help to explain the parasympathetic withdrawal that accompanies heart failure. Furthermore, our observations suggest that nerve growth factor, which is elevated in the failing human heart, causes hypertrophy of neurons in cardiac ganglia.
Article: Distribution and Morphology of Calcitonin Gene-Related Peptide and Substance P Immunoreactive Axons in the Whole-Mount Atria of Mice[Show abstract] [Hide abstract]
ABSTRACT: The murine model has been used to investigate the role of cardiac sensory axons in various disease states. However, the distribution and morphological structures of cardiac nociceptive axons in normal murine tissues have not yet been well characterized. In this study, whole-mount atria from FVB mice were processed with calcitonin gene-related peptide (CGRP) and substance P (SP) primary antibodies followed by secondary antibodies, and then examined using confocal microscopy. We found: 1) Large CGRP-IR axon bundles entered the atria with the major veins, and these large bundles bifurcated into small bundles and single axons that formed terminal end-nets and free endings in the epicardium. Varicose CGRP-IR axons had close contacts with muscle fibers, and some CGRP-IR axons formed varicosities around principle neurons (PNs) within intrinsic cardiac ganglia (ICGs). 2) SP-IR axons also were found in the same regions of the atria, attached to veins, and within cardiac ganglia. Similar to CGRP-IR axons, these SP-IR axons formed terminal end-nets and free endings in the atrial epicardium and myocardium. Within ICGs, SP-IR axons formed varicose endings around PNs. However, SP-IR nerve fibers were less abundant than CGRP-IR fibers in the atria. 3) None of the PNs were CGRP-IR or SP-IR. 4) CGRP-IR and SP-IR often colocalized in terminal varicosities around PNs. Collectively, our data document the distribution pattern and morphology of CGRP-IR and SP-IR axons and terminals in different regions of the atria. This knowledge provides useful information for CGRP-IR and SP-IR axons that can be referred to in future studies of pathological remodeling.
Article: Maternal diabetes increases large conductance Ca2+-activated K+ outward currents that alter action potential properties but do not contribute to attenuated excitability of parasympathetic cardiac motoneurons in the nucleus ambiguus of neonatal mice[Show abstract] [Hide abstract]
ABSTRACT: Previously, we demonstrated that maternal diabetes reduced the excitability and increased small-conductance Ca(2+)-activated K(+) (SK) currents of parasympathetic cardiac motoneurons (PCMNs) in the nucleus ambiguus (NA). In addition, blockade of SK channels with apamin completely abolished this reduction. In the present study, we examined whether maternal diabetes affects large-conductance Ca(2+)-activated K(+) (BK) channels and whether BK channels contribute to the attenuation of PCMN excitability observed in neonates of diabetic mothers. Neonatal mice from OVE26 diabetic mothers (NMDM) and normal FVB mothers (control) were used. The pericardial sac of neonatal mice at postnatal days 7-9 was injected with the tracer X-rhodamine-5 (and 6)-isothiocyanate 2 days prior to the experiment to retrogradely label PCMNs in the NA. Whole cell current- and voltage-clamps were used to measure spike frequency, action potential (AP) repolarization (half-width), afterhyperpolarization potential (AHP), transient outward currents, and afterhyperpolarization currents (I(AHP)). In whole cell voltage clamp mode, we confirmed that maternal diabetes increased transient outward currents and I(AHP) compared with normal cells. Using BK channel blockers charybdotoxin (CTx) and paxilline, we found that maternal diabetes increased CTx- and paxilline-sensitive transient outward currents but did not change CTx- and paxilline-sensitive I(AHP). In whole cell current-clamp mode, we confirmed that maternal diabetes increased AP half-width and AHP, and reduced excitability of PCMNs. Furthermore, we found that after blockade of BK channels with CTx or paxilline, maternal diabetes induced a greater increase of AP half-width but similarly decreased fast AHP without affecting medium AHP. Finally, blockade of BK channels decreased spike frequency in response to current injection in both control and NMDM without reducing the difference of spike frequency between the two groups. Therefore, we conclude that although BK transient outward currents, which may alter AP repolarization, are increased in NMDM, BK channels do not directly contribute to maternal diabetes-induced attenuation of PCMN excitability. In contrast, based on evidence from our previous and present studies, reduction of PCMN excitability in neonates of diabetic mothers is largely dependent on altered SK current associated with maternal diabetes.
Article: Respiratory muscle pacing with chronically implanted intramuscular Permaloc electrodes: A feasibility study[Show abstract] [Hide abstract]
ABSTRACT: We tested the feasibility of stimulating upper-intercostal and abdominal muscles plus the diaphragm by using chronically implanted intramuscular electrodes.During two survival surgeries with six dogs, intramuscular electrodes were implanted bilaterally in the three respiratory muscles. Standard stimulation of the diaphragm was conducted. The dorsolateral and ventrolateral abdominal wall areas were stimulated with a 25 mA current. The second to fourth intercostal spaces were stimulated to elicit the largest tidal volume associated with the least coactivation of the serratus and latissimus muscles. Lone diaphragm and upper-intercostal muscle pacing produced inhaled tidal volumes (mean +/- standard error of the mean) of 293 +/- 36 mL and 59 +/- 17 mL, respectively. Lone abdominal muscle pacing produced an exhaled volume of 55 +/- 17 mL. Combined pacing of diaphragm and intercostal muscles increased the inhaled volume to 389 +/- 39 mL. The addition of abdominal pacing following the combined stimulation of diaphragm and intercostals increased the exhaled volume to 472 +/- 54 mL. During autopsy, dislodgement of the electrodes overlying the ribs was a concern and probably resulted from loose animal jackets. Chronic intramuscular Permaloc electrodes can be implanted in several respiratory muscles and increase tidal volumes more than diaphragm stimulation alone.
Article: Small conductance Ca2+-activated K+ channels regulate firing properties and excitability in parasympathetic cardiac motoneurons in the nucleus ambiguus[Show abstract] [Hide abstract]
ABSTRACT: Small conductance Ca(2+)-activated K(+) channels (SK) regulate action potential (AP) firing properties and excitability in many central neurons. However, the functional roles of SK channels of parasympathetic cardiac motoneurons (PCMNs) in the nucleus ambiguus have not yet been well characterized. In this study, the tracer X-rhodamine-5 (and 6)-isothiocyanate (XRITC) was injected into the pericardial sac to retrogradely label PCMNs in FVB mice at postnatal days 7-9. Two days later, XRITC-labeled PCMNs in brain stem slices were identified. With the use of whole cell current clamp, single APs and spike trains of different frequencies were evoked by current injections. We found that 1) PCMNs have two different firing patterns: the majority of PCMNs (90%) exhibited spike frequency adaptation (SFA) and the rest (10%) showed less or no adaptation; 2) application of the specific SK channel blocker apamin significantly increased spike half-width in single APs and trains and reduced the spike frequency-dependent AP broadening in trains; 3) SK channel blockade suppressed afterhyperpolarization (AHP) amplitude following single APs and trains and abolished spike-frequency dependence of AHP in trains; and 4) SK channel blockade increased the spike frequency but did not alter the pattern of SFA. Using whole cell voltage clamp, we measured outward currents and afterhyperpolarization current (I(AHP)). SK channel blockade revealed that SK-mediated outward currents had both transient and persistent components. After bath application of apamin and Ca(2+)-free solution, we found that apamin-sensitive and Ca(2+)-sensitive I(AHP) were comparable, confirming that SK channels may contribute to a major portion of Ca(2+)-activated K(+) channel-mediated I(AHP). These results suggest that PCMNs have SK channels that significantly regulate AP repolarization, AHP, and spike frequency but do not affect SFA. We conclude that activation of SK channels underlies one of the mechanisms for negative control of PCMN excitability.
Article: Maternal Diabetes Increases Small Conductance Ca2+-Activated K+ (SK) Currents That Alter Action Potential Properties and Excitability of Cardiac Motoneurons in the Nucleus Ambiguus[Show abstract] [Hide abstract]
ABSTRACT: Parasympathetic cardiac motoneurons (PCMNs) in the nucleus ambiguus (NA) play a key role in regulating cardiac functions. In this study, we examined the effects of maternal diabetes on excitability, action potential (AP) properties, and small conductance Ca(2+)-activated K(+) (SK) currents of PCMNs. Neonatal mice from diabetic (OVE26 female, NMDM) and normal (FVB female, control) mothers that had been mated with nondiabetic fathers (FVB male) were used. Tracer XRITC was injected into the pericardial sac at P7-9 to retrogradely label PCMNs. Two days later, XRITC-labeled PCMNs were identified in brain stem slices. The responses of spike frequency, AP repolarization (half-width) and afterhyperpolarization (AHP) of PCMNs to current injections were studied using whole cell current clamp. Outward and afterhyperpolarization currents (I(AHP)) in response to voltage steps were measured using whole cell voltage clamp. In examining the effects of maternal diabetes on excitability and AP properties, we found that in NMDM spike frequency decreased, the half-width and AHP peak amplitude increased, and the peak amplitude of outward transient currents and I(AHP) increased compared with those measured in control. In examining the effects of maternal diabetes on SK channels, we found that after blockage of SK channels with a specific SK channel blocker apamin, maternal diabetes significantly increased apamin-sensitive outward transient currents and I(AHP), and suppressed AHP amplitude in NMDM more than those in control. Further, apamin application increased the firing rate to current injections and completely abolished the difference of the firing rate between control and NMDM. We suggest that the augmented SK-mediated currents may contribute to the increased AHP amplitude and the attenuated excitability of PCMNs in NMDM.
Article: Structural Remodeling of Vagal Afferent Innervation of Aortic Arch and Nucleus Ambiguus (NA) Projections to Cardiac Ganglia in a Transgenic Mouse Model of Type 1 Diabetes (OVE26)[Show abstract] [Hide abstract]
ABSTRACT: Diabetes-induced structural changes of vagal aortic afferent and cardiac efferent axons are not well understood. FVB control and OVE26 diabetic mice at different ages received injections of the tracer tetramethylrhodamine dextran (TMR-D) into the nodose ganglion to label vagal aortic afferents (at 3 and 6 months), or DiI injections into the nucleus ambiguus to label vagal cardiac efferents (at 3, 6, and 9 months). The aortic arch and atria were examined by using confocal microscopy. In the aortic arch, TMR-D labeled large and small vagal afferent axons (axons(L) and axons(S)) that formed different types of terminals: axons(L) produced large flower-sprays (flower-sprays(L)) and end-nets (end-nets(L)), whereas axons(S) produced small flower-sprays (flower-sprays(S)) and end-nets (end-nets(S)). In the atria, DiI-labeled vagal efferent axons formed basket endings around ganglion principle neurons (PNs). The vagal afferents, PNs and vagal cardiac efferents in diabetic mice were compared with age-matched control mice. We found (P < 0.05) that: 1) the size of axons(L), flower-sprays(L), flower-sprays(S) and end-nets(S) were reduced at 6 and 9 months; 2) the size of cardiac ganglia and the somatic area of the PNs were decreased, and the PN density in cardiac ganglia was increased at all ages and the PN nuclei/soma area ratio was increased at 9 months; and 3) the percentage of DiI-labeled axons-innervated PNs was decreased at all ages. Furthermore, the number of synaptic-like terminal varicosities around PNs was decreased. Compared with 3 months, more advanced diabetes at 9 months further reduced the number of varicosities/PN. In addition to these changes, swollen axons and terminals, as well as leaky-like DiI-labeled terminals, were observed in long-term diabetic mice (6 and 9 months of age). Taken together, our data show that chronic diabetes induces a significant structural atrophy of vagal aortic afferent and cardiac efferent axons and terminals. Although different morphologies of vagal afferent terminals in the aortic arch may serve as substrates for the future investigation of aortic depressor afferent physiology, structural remodeling of vagal afferents and efferents provides a foundation for further analysis of diabetes-induced impairment of cardiac autonomic regulation.
- [Show abstract] [Hide abstract]
ABSTRACT: To test the feasibility of implanting intramuscular electrodes (Permaloc, Synapse Biomedical Inc, Oberlin OH) with self-securing polypropylene anchors to stimulate upper-intercostal and abdominal muscles plus the diaphragm. In 6 anesthetized dogs, 12 Permaloc electrodes were implanted in the 3 respiratory muscles (4 in each muscle group). Tidal volume with diaphragmatic stimulation was 310 +/- 38 mL (mean +/- SE); with upper intercostal stimulation, it was 68 +/- 18 mL; and with combined diaphragm intercostal stimulation, it was 438 +/- 78 mL. By study design, stimulation in the upper intercostal muscles was limited to not more than slight/moderate contraction of the serratus and latissimus muscles overlying the ribs. Abdominal muscle stimulation produced exhaled volumes of 38 +/- 20 mL (this stimulation was limited by the maximal output of the stimulator of 25 milliamperes). Combined diaphragm intercostal stimulation followed by abdominal muscle stimulation increased exhaled volumes from 312 +/- 31 mL to 486 +/- 58 mL (P = 0.024). Permaloc electrodes can be successfully implanted in upper intercostal and abdominal muscles in addition to the diaphragm. Combined diaphragm intercostal stimulation followed by abdominal muscle stimulation increased the exhaled volumes recorded with diaphragmatic stimulation alone.
Article: Impairment of baroreflex control of heart rate and structural changes of cardiac ganglia in conscious streptozotocin (STZ)-induced diabetic mice[Show abstract] [Hide abstract]
ABSTRACT: Baroreflex control of heart rate (HR) is impaired in human diabetes mellitus and in large experimental models. However, baroreflex impairment in diabetic mouse models and diabetes-induced remodeling of baroreflex circuitry are not well studied. We examined the impairment of baroreflex control of heart rate (HR) and assessed structural remodeling of cardiac ganglia in the streptozotocin (STZ)-induced diabetic mouse model. FVB mice were either injected with vehicle or STZ. Group 1: mice were anesthetized and the femoral artery and vein were catheterized at the 30th day after vehicle or STZ injection. On the second day after surgery, baroreflex-mediated HR responses to sodium nitroprusside (SNP) and phenylephrine (PE)-induced mean arterial blood pressure (MABP) changes were measured in conscious mice. Group 2: Fluoro-Gold was administered (i.p.) to label cardiac ganglia in each mouse at the 25th day after vehicle or STZ injection. After another five days, animals were perfused and cardiac ganglia were examined using confocal microscopy. Compared with control, we found in STZ mice: 1) the HR decreased, but MABP did not. 2) The PE-induced increases of MABP were decreased. 3) Baroreflex bradycardia was attenuated in the rapid MABP ascending phase but the steady-state DeltaHR/DeltaMABP was not different at all PE doses. 4) SNP-induced MABP decreases were not different. 5) Baroreflex tachycardia was attenuated. 6) The sizes of cardiac ganglia and ganglionic principal neurons were decreased. 7) The ratio of nucleus/cell body of cardiac ganglionic neurons was increased. We conclude that baroreflex control of HR is impaired in conscious STZ mice. In addition, diabetes may induce a significant structural remodeling of cardiac ganglia. Such an anatomical change of cardiac ganglia may provide new information for the understanding of diabetes-induced remodeling of the multiple components within the baroreflex circuitry.
- [Show abstract] [Hide abstract]
ABSTRACT: Baroreflex control of heart rate (HR) is impaired in human type 1 diabetes mellitus. The goal of this study is to use a transgenic mouse model of type 1 diabetes (OVE26) to assess the diabetes-induced baroreflex impairment in the conscious state. OVE26 transgenic mice (which develop hyperglycemia within the first three weeks after birth due to the specific damage of beta cells) and normal control mice (FVB) 5-6months of age were anesthetized, and the left femoral artery and both veins were catheterized. On the second day after surgery, baroreflex-mediated HR responses to arterial blood pressure (ABP) changes that were induced by separate microinfusion of phenylephrine (PE) and sodium nitroprusside (SNP) at different doses (0.03-0.4microg/min) were measured in the conscious state. Compared with FVB control, we found that in OVE26 diabetic mice 1) mean ABP (MABP) and HR were decreased (p<0.05). 2) PE-induced MABP increases were comparable to those in FVB mice (p>0.05). 3) Baroreflex-mediated bradycardia was attenuated (p<0.05). 4) SNP-induced MABP decreases was reduced (p<0.05). 5) Baroreflex-mediated tachycardia was attenuated (p<0.05). Since baroreflex control of HR in conscious OVE26 mice is impaired in a similar fashion to human diabetes mellitus, we suggest that OVE26 mice may provide a useful model to study the neural mechanisms of diabetes-induced baroreflex impairment.
- [Show abstract] [Hide abstract]
ABSTRACT: Better methods are needed for recording urethral function for complex urologic problems involving the bladder, urethra, and pelvic floor. To evaluate a balloon catheter for recording urethral pressure and function using bench-top testing and evaluation in an animal model. Balloon pressure-recording methods included slightly inflating the balloon with water and placing the pressure transducer on the distal end of the catheter. For bench-top testing, manual procedures and a silastic tube with a restriction were used. In 3 anesthetized dogs, pressure recorded from the skeletal urethral sphincter was induced with electrical stimulation of the sphincter. Anal sphincter pressure was also recorded. Bench-top testing showed good pressure recordings, including a confined peak at the tube restriction. Animal tests showed urethral pressure records with rapid responses when electrical stimulation was applied. Peak pressure at the urethral skeletal sphincter was 55.7 +/- 15 cmH2O, which was significantly higher than the peak pressure recorded 2 cm distally in the proximal urethra (3.3 +/- 2.3 cmH2O). Peak anal pressures were smaller and unchanged for the 2 stimulations. Balloon-pressure recordings showed rapid responses that were adequate for the tests conducted. In the animal model, high-pressure contractions specific to the skeletal urethral sphincter were shown. Balloon-tipped catheters warrant further investigation and may have applications for the evaluation of detrusor-sphincter dyssynergia after spinal cord injury or for stress urinary incontinence.
Article: Diabetes induces neural degeneration in nucleus ambiguus (NA) and attenuates heart rate control in OVE26 mice[Show abstract] [Hide abstract]
ABSTRACT: Baroreflex sensitivity is impaired by diabetes mellitus. Previously, we found that diabetes induces a deficit of central mediation of baroreflex-mediated bradycardia. In this study, we assessed whether diabetes induces degeneration of the nucleus ambiguus (NA) and reduces heart rate (HR) responses to l-Glutamate (L-Glu) microinjection into the NA. FVB control and OVE26 diabetic mice (5-6 months) were anesthetized. Different doses of L-Glu (0.1-5 mM/l, 20 nl) were delivered into the left NA using a multi-channel injector. In other animals, the left vagus was electrically stimulated at 1-40 Hz (1 ms, 0.5 mA, 20 s). HR and mean arterial blood pressure (MAP) responses to L-Glu microinjections into the NA and to the electrical stimulation of the vagus were measured. The NA region was defined by tracer TMR-D injection into the ipsilateral nodose ganglion to retrogradely label vagal motoneurons in the NA. Brainstem slices at -600, -300, 0, +300, and +600 mum relative to the obex were processed using Nissl staining and the number of NA motoneurons was counted. Compared with FVB control, we found in OVE26 mice that: 1) HR responses to L-Glu injection into the NA at doses of 0.2-0.4 (mM/l, 20 nl) were attenuated (p<0.05), but MAP responses were unchanged (p>0.05). 2) HR responses to vagal stimulation were increased (p<0.05). 3) The total number of NA (left and right) motoneurons was reduced (p<0.05). Taken together, we concluded that diabetes reduces NA control of HR and induces degeneration of NA motoneurons. Degeneration of NA cardiac motoneurons may contribute to impairment of reflex-bradycardia in OVE26 diabetic mice.
Article: Vagal afferent innervation and remodeling in the aortic arch of young-adult Fischer 344 rats following chronic intermittent hypoxia[Show abstract] [Hide abstract]
ABSTRACT: Previously, we have shown that chronic intermittent hypoxia (CIH) impairs baroreflex control of heart rate and augments aortic baroreceptor afferent function. In the present study, we examined whether CIH induces structural changes of aortic afferent axons and terminals. Young-adult Fischer 344 (F344, 4 months old) rats were exposed to room air (RA) or CIH for 35-45 days. After 14-24 days of exposure, they received tracer DiI injection into the left nodose ganglion to anterogradely label vagal afferent nerves. After surgery, animals were returned to their cages to continue RA or CIH exposure. Twenty-one days after DiI injection, the animals were sacrificed and the aortic arch was examined using confocal microscopy. In both RA and CIH rats, we found that DiI-labeled vagal afferent axons entered the wall of the aortic arch, then fanned out and branched into large receptive fields with numerous terminals (flower-sprays, end-nets and free endings). Vagal afferent axons projected much more to the anterior wall than to the posterior wall. In general, the flower-sprays, end-nets and free endings were widely and similarly distributed in the aortic arch of both groups. However, several salient differences between RA and CIH rats were found. Compared to RA control, CIH rats appeared to have larger vagal afferent receptive fields. The CIH rats had many abnormal flower-sprays, end-nets, and free endings which were intermingled and diffused into "bush-like" structures. However, the total number of flower-sprays was comparable (P>0.05). Since there was a large variance of the size of flower-sprays, we only sampled the 10 largest flower-sprays from each animal. CIH substantially increased the size of large flower-sprays (P<0.01). Numerous free endings with enlarged varicosities were identified, resembling axonal sprouting structures. Taken together, our data indicate that CIH induces significant remodeling of afferent terminal structures in the aortic arch of F344 rats. We suggest that such an enlargement of vagal afferent terminals may contribute to altered aortic baroreceptor function following CIH.
Article: Impaired baroreflex control of renal sympathetic nerve activity (RSNA) in type 1 diabetic mice (OVE26)[Show abstract] [Hide abstract]
ABSTRACT: To investigate the effects of chronic diabetes on baroreflex control of renal sympathetic nerve activity (RSNA), OVE26 diabetic (transgenic mouse line which develops hyperglycemia within the first 3 weeks after birth) and FVB control mice 5-6 months old were studied. Under anesthesia, RSNA in response to sodium nitroprusside (SNP)- and phenylephrine (PE)-induced mean arterial pressure changes (DeltaMAP) were measured. Baroreflex-induced inhibition of RSNA during PE infusion was characterized using the sigmoid logistic function curve. Baroreflex-induced excitation of RSNA during SNP infusion was characterized by the RSNA vs. DeltaMAP relationship. Mean arterial pressure (MAP) responses to the left aortic depressor nerve (ADN) stimulation were evaluated. Compared to FVB control, we found in OVE26 mice that (1) RSNA in response to MAP increase during PE infusion was dramatically reduced, as characterized by the maximal gain of the RSNA sigmoid logistic function curve (FVB: -20.0+/-5.1; OVE26: -7.6+/-0.8%/mm Hg, P<0.05); (2) RSNA in response to MAP decrease during SNP infusion was also attenuated (P<0.05); (3) MAP responses to ADN stimulation were reduced (P<0.05). We concluded that chronic diabetes impairs baroreflex control of RSNA in OVE26 diabetic mice. The use of the transgenic OVE26 diabetic mouse model may underlie a foundation for the further understanding of diabetes-induced autonomic neuropathy.
Article: Nitric oxide and carbon monoxide synthesizing enzymes and soluble guanylyl cyclase within neurons of adult human cardiac ganglia[Show abstract] [Hide abstract]
ABSTRACT: Nitric oxide and carbon monoxide are diffusible gas messengers, synthesized by nitric oxide synthase or heme oxygenase 2, respectively, that can activate soluble guanylyl cyclase in adjacent cells. Nitric oxide and carbon monoxide neuromodulation in cardiac ganglia has been demonstrated. However, identification of nitric oxide or carbon monoxide in human cardiac ganglia needs to be confirmed as suggested from animal model studies. Immunohistochemistry was used to demonstrate neuronal nitric oxide synthase, heme oxygenase 2, and soluble guanylyl cyclase immunoreactivity within neurons of adult human cardiac ganglia. Nitric oxide synthase immunoreactivity was present in 37% of neurons within cardiac ganglia, heme oxygenase 2 immunoreactivity in 79%, and soluble guanylyl cyclase in 53%. Our findings support the hypothesis that nitric oxide and carbon monoxide are modulators of neurotransmission in cardiac ganglia and in neural control of the adult human heart.
Article: Effects of electrical stimulation and gonadal steroids on rat facial nerve regenerative properties[Show abstract] [Hide abstract]
ABSTRACT: The neurotherapeutic effects of nerve electrical stimulation and gonadal steroids have independently been demonstrated. The purpose of this study was to investigate the therapeutic potential of a combinatorial treatment strategy of electrical stimulation and gonadal steroids on peripheral nerve regeneration. Following a facial nerve crush axotomy in gonadectomized adult male rats, testosterone propionate (TP), dihydrotestosterone (DHT), or estradiol (E(2)) was systemically administered with/without daily electrical stimulation of the proximal nerve stump. Facial nerve outgrowth was assessed at 4 and 7 days post-axotomy using radioactive labeling. Administration of electrical stimulation alone reduced the estimated delay in sprout formation but failed to accelerate the overall regeneration rate. Conversely, TP treatment alone accelerated the regeneration rate by approximately 10% but had no effect on the sprouting delay. Combining TP with electrical stimulation, however, maintained the enhanced rate and reduced the sprouting delay. DHT treatment alone failed to alter the regeneration rate but combining it with electrical stimulation increased the rate by 10%. E(2) treatment alone increased the regeneration rate by approximately 5% but with electrical stimulation, there was no additional effect. Electrical stimulation and gonadal steroids differentially enhanced regenerative properties. TP, an aromatizable androgen, augmented regeneration most, suggesting a synergism between androgenic and estrogenic effects. Therapeutically, combining electrical stimulation with gonadal steroids may boost regenerative properties more than the use of either treatment alone.
Article: Chronic intermittent hypoxia impairs heart rate responses to AMPA and NMDA and induces loss of glutamate receptor neurons in nucleus ambiguus of F344 rats[Show abstract] [Hide abstract]
ABSTRACT: Chronic intermittent hypoxia (CIH), as occurs in sleep apnea, impairs baroreflex-mediated reductions in heart rate (HR) and enhances HR responses to electrical stimulation of vagal efferent. We tested the hypotheses that HR responses to activation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and N-methyl-D-aspartate (NMDA) receptors in the nucleus ambiguous (NA) are reduced in CIH-exposed rats and that this impairment is associated with degeneration of glutamate receptor (GluR)-immunoreactive NA neurons. Fischer 344 rats (3-4 mo) were exposed to room air (RA) or CIH for 35-50 days (n = 18/group). At the end of the exposures, AMPA (4 pmol, 20 nl) and NMDA (80 pmol, 20 nl) were microinjected into the same location of the left NA (-200 microm to +200 microm relative to caudal end of area postrema; n = 6/group), and HR and arterial blood pressure responses were measured. In addition, brain stem sections at the level of -800, -400, 0, +400, and +800 microm relative to obex were processed for AMPA and NMDA receptor immunohistochemistry. The number of NA neurons expressing AMPA receptors and NMDA receptors (NMDARs) was quantified. Compared with RA, we found that after CIH 1) HR responses to microinjection of AMPA into the left NA were reduced (RA -290 +/- 30 vs. CIH -227 +/- 15 beats/min, P < 0.05); 2) HR responses to microinjection of NMDA into the left NA were reduced (RA -302 +/- 16 vs. CIH -238 +/- 27 beats/min, P < 0.05); and 3) the number of NMDAR1, AMPA GluR1, and AMPA GluR2/3-immunoreactive cells in the NA was reduced (P < 0.05). These results suggest that degeneration of NA neurons expressing GluRs contributes to impaired baroreflex control of HR in rats exposed to CIH.
Article: Accelerating functional recovery after rat facial nerve injury: Effects of gonadal steroids and electrical stimulation[Show abstract] [Hide abstract]
ABSTRACT: We investigated the combined effects of electrical stimulation and testosterone propionate on overall recovery time in rats with extracranial crush injuries to the facial nerve. Male rats underwent castration 3 to 5 days prior to right facial nerve crush injury and electrode implantation. Rats were randomly assigned to two groups: crush injury + testosterone or crush injury with electrical stimulation + testosterone. Recovery was assessed by daily subjective examination documenting vibrissae orientation/movement, semi-eye blink, and full eye blink. Milestones of early recovery were noted to be significantly earlier in the groups with electrical stimulation, with/without testosterone. The addition of testosterone to electrical stimulation showed significant earlier return of late recovery parameters and complete overall recovery. Electrical stimulation may decrease cell death or promote sprouting to accelerate early recovery. Testosterone may affect the actual rate of axonal regeneration and produce acceleration in functional recovery. By targeting different stages of neural regeneration, the synergy of electrical stimulation and testosterone appears to have promise as a neurotherapeutic strategy for facial nerve injury.
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ABSTRACT: To study the effect of electrical stimulation on accelerating facial nerve functional recovery from a crush injury in the rat model. Experimental. The main trunk of the right facial nerve was crushed just distal to the stylomastoid foramen, causing right-sided facial paralysis in 17 Sprague-Dawley rats. An electrode apparatus was implanted in all rats. Nine rats underwent electrical stimulation and eight were sham stimulated until complete facial nerve recovery. Facial nerve function was assessed daily by grading eyeblink reflex, vibrissae orientation, and vibrissae movement. An electrical stimulation model of the rat facial nerve following axotomy was established. The semi-eyeblink returned significantly earlier (3.71 + 0.97 vs 9.57 + 1.86 days post axotomy) in stimulated rats (P = 0.008). Stimulated rats also recovered all functions earlier, and showed less variability in recovery time. Electrical stimulation initiates and accelerates facial nerve recovery in the rat model as it significantly reduces recovery time for the semi-eyeblink reflex, a marker of early recovery. It also hastens recovery of other functions.
Top Journals
Loyola UniversityNew Orleans, Louisiana, United States
Edward Hines, Jr. VA HospitalHines, Oregon, United States
Loyola University Chicago
Chicago, Illinois, United States
- • Physiology
- • Department of Neurological Surgery
- • Stritch School of Medicine
Loyola University Medical Center
Maywood, Illinois, United States
- • Department of Physiology
- • Department of Neurological Surgery
University of Pittsburgh
Pittsburgh, Pennsylvania, United States
- Rehabilitation Science and Technology
Taylor University
Upland, Indiana, United States
- Biology Department
Dalhousie University
Halifax, Nova Scotia, Canada
- Department of Physiology and Biophysics
University of Illinois at ChicagoChicago, Illinois, United States


text:
Translation of pants in Spanish:
plural noun
- 1 (trousers) (American English) a pair of pantsun par de pantalonesto bore the pants off somebody (also British English) [colloquial]
unos pantalones
un pantalónmatar a alguien de aburrimientoto scare the pants off somebody (also British English) [colloquial]darle a alguien un susto de muerteExample sentences
- The women that Isis had a glimpse of wore either bell-bottomed trousers, denim pants, or blue jeans.
- The shirts tucked into tight, ebony brown rawhide pants, trousers designed to keep the warmth in and the cold out.
- Lord I am so grateful for drawstring pants and trousers with elastic.
- 2 (underwear) (British English) 2.1 (men's)interiores (masculine plural) (Colombia) (Venezuela)to catch somebody with his pants down [colloquial]agarrar or (esp Spain) coger a alguien desprevenidoExample sentences2.2 (women's) → panties 2.3 (British English) [slang] (nonsense)
tonterías (feminine plural)
- The chaps Tom and I have styled all bought pants or boxers and vests and have all reported back that they are soft, fit really well and that their women think they look much better.
- Many stores now sell bikinis as separates, so you can buy the pants and bra in different sizes to ensure a perfect fit.
- Department store Marks & Spencer is launching an underwear range for men featuring thongs and glittery pants.
pendejadas (feminine plural) (Latin America exc Southern Cone) [colloquial]
chorradas (feminine plural) (Spain) [colloquial]
pavadas (feminine plural) (River Plate area) [colloquial]
leseras (feminine plural) (Chile) [colloquial]Example sentences2.4 (British English) [colloquial] (rubbish) the film was pants
la película fue una porquería
- It's not art - it's pants.
- I thought I'd give it a go. Unfortunatly, I'd not looked at the opinions of others on Ciao..........boy, do I wish I had! It's pants. It really is a poor program.
Definition of pants in:
- British & World English dictionary
- US English dictionary
- English synonyms
- US English synonyms
- Spanish dictionary
What do you find interesting about this word or phrase?
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Grammar and usage help for Spanish:
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text:
Suntsch Miqote : Striped bikini by emperpepWatch
©2014-2016 emperpep
lol i love this XD I play a Moqo'e too, except she's a white mage main XD soon to be astrologian main lolmy white mage is very ._.; modestly dressed lol man i love ur arts ^_^
<_> ....
Which hairstyle is that?
This would be actually fun looking tank to play as... as my own Miqote is pretty near same looking otherwise.
Too bad FF14 doesn't feature lightblue striped bikinis by default.
Too bad FF14 doesn't feature lightblue striped bikinis by default.
She looks bushed. Water? Food? May I request a commisson list? Can you design other creatures, &, multiple body parts?
This is just great. I really like all your work.
luv the sword.
Pretty hot
Perfect Beauty :3
Ooh, she looks beautiful!!
Busty catgirls ina rmor press all of my hnnng buttons
Sooooo cute and hot !
Nice shading on her body.
Like it!
stripes in all the right places
very nice
too cute
stripeed armor!!!!!!!!!!!
keke~ I see what you did there! XD followedd you on PW as well ^w^
cute ^_^
The shading stands out to me the most, it does a lot to show off the bodyshape without shoving it in your face like hard lines.
Pretty much every single Female Miqo'te when Patch 2.2 was out and Glamours available... All the bikini!
Like! ; )
just absolutely love how you shaded the stomach~
Can't swim in with that armor still on, but it doesn't look like she's gonna swim.
Dayum. Wicked!
Very cute! nice colors :3
Excellent work; this turned out excellent!
Love all the versions
So beautiful!! Love it!
I Have got to shoot you a Commission Some time in the near future you works are always so pretty and amazing
i favorite this 1,000,000 times .
She is too sweet!
Good work!!!!
I'll take three.
What an efficient armor.
<333333 thank you
Awesome work!
Avec une chaleur pareille (je suppose), elle doit avoir la peau fondue sous l'armure... XD
belles couleurs ^^
belles couleurs ^^
nice armor!
wow, impressive... and how you color it.. its so warm
Looks good, as ever - I look foward to seeing the tumblr versions too


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All Giant Bicycle: Page 2
Pro Bike Gallery: Carl Decker's Giant Anthem
- By Logan VonBokel
- Published Jul. 26, 2013
Decker goes against the grain and chooses a mountain bike for the Raleigh Midsummer's Night CX race, which pays off in the form of a win
Giant introduces revamped line of 2014 cyclocross bikes
- By Spencer Powlison
- Published Jul. 25, 2013
- Updated Jul. 30, 2014 at 6:41 PM EST
Disc brakes are the common theme throughout all of the models
Are in-house wind tunnels really worth it for bike companies?
- By Lennard Zinn
- Published Jun. 26, 2013
- Updated Oct. 30, 2014 at 5:27 PM EST
Giant questions the revenue and technology benefits after Specialized and Ridley go in-house with their aero testing
Review: Giant's understated P-SLR 1 Wheels
- By Spencer Powlison
- Published Mar. 11, 2013
- Updated Jul. 30, 2014 at 6:38 PM EST
Giant's new affordable, aftermarket wheels are stiff and fast despite alloy construction
Ride Report: Giant Propel Advanced SL
- By Caley Fretz
- Published Jan. 30, 2013
Forget wind tunnel data, Giant's new aero road frame stands up to our first four days of riding on its ride qualities alone
Pro Bike Gallery: Tom-Jelte Slagter's Giant Propel Advanced SL
- By Caley Fretz
- Published Jan. 28, 2013
- Updated Jan. 28, 2013 at 1:30 PM EST
We detail Tom-Jelte Slagter's new Giant aero road frame, which he piloted to the Tour Down Under title last week
Fretz Gallery: Giant Propel Advanced SL
- By Caley Fretz
- Published Jan. 19, 2013
Velo tech editor Caley Fretz snaps the all-new Giant Propel Advanced SL aero road bike from Adelaide, Australia
Giant flies into aero road market with Propel, Envie frames
- By Caley Fretz
- Published Jan. 17, 2013
- Updated Jan. 18, 2013 at 3:29 PM EST
Men's and women's aero road frames debut in Australia
First ride: Giant Anthem X 29er W
- By Emily Zinn
- Published Sep. 28, 2012
- Updated Oct. 30, 2014 at 10:16 AM EST
The first women's-specific full-suspension 29er from Giant is a competitive bike at a competitive price
Giant launches Propel Advanced aero road bike at Eurobike
- By Caley Fretz
- Published Aug. 31, 2012
Asian manufacturer unveils its aero road offering in Germany


text:
Federal Reserve Chairman at House Hearing
Federal Reserve Chairman Ben Bernanke will testify on the U.S. economy today before the House Budget Committee. Representative Gwen… read more
Federal Reserve Chairman Ben Bernanke will testify on the U.S. economy today before the House Budget Committee. Representative Gwen Moore, who is on the Budget Committee, talked about what she will be asking the Chairman, her views on the current bailout law, and how it is affecting her district. She responded to telephone calls and electronic mail. close
People in this video
- Gwendolynne "Gwen" Moore U.S. Representative [D] Wisconsin
- Bill Scanlan Host C-SPAN
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Police Bust Kidney Scam Targeting India's Poor
Police in India have uncovered an illegal kidney transplant racket in which hundreds of poor laborers were duped or forced into giving up their organs for wealthy Indians and foreigners.
The scam was centered in a city of high-tech companies just outside New Delhi.
Although several such operations have been discovered in India in recent years, the scale of this one is described as unprecedented.
Related NPR Stories
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Vt. Senate supports board: No pets in hair salonsThe Associated Press | April 30,2013MONTPELIER - The Vermont Senate has gone on record supporting a state board's ruling that pets don't belong in barber shops and beauty parlors.
In a 14-13 vote, the Senate defeated an amendment by Democratic Sen. Richard Sears of Bennington that would have allowed animals in commercial hair-cutting establishments.
Sears says he pushed for the measure after an inspector for the state Board of Cosmetology cited Bennington-area businesses for allowing pets on the premises.
The measure failed after Sen. Anthony Pollina of Washington County argued that regulatory boards should be allowed to make such decisions without interference by lawmakers.
An exception is made for service animals like seeing-eye dogs, which are allowed in commercial establishments under the Americans With Disabilities Act.MORE IN This Just InPROCTOR A citizen committee has finalized a survey to poll residents on a new town office... Full StoryAn attorney for environmental advocate Annette Smith has asked the Vermont attorney generals... Full StoryRANDOLPH CENTER A Midwest farmer with an innovative approach to managing his dairy operation... Full Story
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A 3 day safari to Selous game reserve takes you for an amazing bush experience ,boat safari on arrival,full day game drive the following day and a nature walk before drive back to Dar es salaam
World Tours & Safaris Tanzania is a licensed safari company based in Arusha, Tanzania which has been specializing in quality safaris and mountain trekking at reasonable prices for more than 11 years now with positive recommendations from clients.
Experience the best of Wildebeests Migration in the Serengeti (Ndutu) areas where thousands of Wildebeests accompanied by Zebras congregate during early December to late March every year doting these vast plains which seemed inhabitable in dry season
Want a real adventure in the natural world? Looking for personalized service and a priceless experience? We ensure that you will get all that and more guaranteed inclusions of high quality! That is our profound pledge to you all.
An unforgettable experience as you witness the wildebeest migration, catch the big five, breakfast by the hippo pools, boating, photography and exotic bush suppers.
Kenya tour operator offering Lodge Safaris, Kenya Flying Safaris, Budget safaris,Luxury lodge safaris & tours to Kenya, Tanzania, Uganda & South Africa for both the upmarket & budget traveller; includes beach holidays, Mt Kenya and Mt Kili climbing.
Enjoy breathtaking views of Mt.Kenya,rare northern specialist species, bird watching and boating
Nairobi based outfitter providing tours and travel management services in East Africa. Contact us for your travel arrangements in Kenya & Tanzania. We offer tailor made Safaris and Tours; Car Hire Services, Mountain Climbing, Mombasa & Zanzibar Beach
This is a flying package safari targeting clients who want to make the most of a 3 days safari to the Masai Mara Game Reserve. Ashnil Mara Camp, which is a 45 minute flight from Wilson Airport Nairobi, boasts of over 30 luxury tents close to the Mara
Explore the largest inland Delta in the world. All inclusive Safari experience with your own guide for 4 days in the heart of Botswana's Okavango Delta close to Chief's Island. Fly-in or self-drive as trips depart from Maun the tourist capital.
Go on a safari on your vacation! Observe animals and wildlife on our safari tours in Africa. Our safari trips are a great overland journey. Take amazing photography on our wildlife tours. See wild animals up close in their natural habitats on our wildlife trips in Africa. Our safari vacations are an exciting adventure for any animal lover or outdoor enthusiast. Browse our safaris in Africa and plan your wildlife vacation today!


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Book your room at Palace Hotel Saigon
Deluxe RoomMax Occupancy: 3 guests (up to 2 children, 2 infants)
Deluxe Room, City ViewMax Occupancy: 3 guests (up to 2 children, 2 infants)
Family SuiteMax Occupancy: 3 guests (up to 2 children, 2 infants)
Palace SuiteMax Occupancy: 3 guests (up to 2 children, 2 infants)
Get an overview of this hotel4-star Ho Chi Minh City hotel in Dong Khoi with 3 restaurants
Located in Dong Khoi, this spa hotel is within a 5-minute walk of Saigon Tax Trade Center, Ho Chi Minh City Hall Square, and Saigon Skydeck. Opera House and Ho Chi Minh City Hall are also within 10 minutes.
Hotel Features
Along with 3 restaurants, this smoke-free hotel has a full-service spa and an outdoor pool. WiFi in public areas is free. Additionally, a health club, a bar/lounge, and a swim-up bar are onsite.
Room Amenities
All 144 rooms feature comforts like pillowtop beds and down comforters, while conveniences include refrigerators and coffee makers. Other amenities available to guests include free WiFi, cable TV, and minibars.Information missing or incorrect? Tell us!Opens in a new window
Hotel Amenities
Hotel Amenities
In addition to a full-service spa, Palace Hotel Saigon features an outdoor pool and a health club. Dining is available at one of the hotel's 3 restaurants and guests can grab coffee at the coffee shop/café. Guests can unwind with a drink at one of the hotel's bars, which include a swim-up bar and a bar/lounge. Public areas are equipped with complimentary high-speed wired and wireless Internet access.
This 4-star property offers access to a 24-hour business center and meeting rooms. 3 meeting rooms are available. This business-friendly hotel also offers a spa tub, a sauna, and a steam room. For a surcharge, a roundtrip airport shuttle (available on request) is offered to guests.
Palace Hotel Saigon is a smoke-free property.
- 24-hour business center
- 24-hour front desk
- Airport transportation (surcharge)
- Bar/lounge
- Breakfast available (surcharge)
- Coffee shop or café
- Free newspapers in lobby
- Conference space
- Designated smoking areas
- Dry cleaning/laundry service
- Elevator/lift
- Free WiFi
- Free wired high-speed Internet
- Full-service spa
- Hair salon
- Health club
- Luggage storage
- Meeting rooms
- Number of buildings/towers - 1
- Number of floors - 16
- Number of meeting rooms - 3
- Number of restaurants - 3
- Outdoor pool
- Porter/bellhop
- Safe-deposit box at front desk
- Sauna
- Smoke-free property
- Spa treatment room(s)
- Spa tub
- Steam room
- Swim-up bar
- Total number of rooms - 144
- Tours/ticket assistance
- Wedding services
- Year Built 1973
Business Travel Amenities
- Business center
- Airport transportation
- Dry cleaning or laundry services
- Conference rooms
- Business services
- Free WiFi
- Meeting rooms
Family Friendly Amenities
- Free Wi-Fi
- Outdoor pool
- Refrigerator
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi , Free wired high-speed Internet
Room Amenities
- Air conditioning
- Bathtub or shower
- Cable TV service
- Coffee/tea maker
- Free toiletries
- Daily housekeeping
- Down comforter
- Free WiFi
- Hair dryer
- In-room safe
- Minibar
- Phone
- Pillowtop mattress
- Private bathroom
- Refrigerator
- Room service
Where to Eat
Buffet breakfasts are available for a surcharge and are served each morning.
Golden Palace,Palace cafe - This restaurant serves breakfast, lunch, and dinner.
Room service is available.
Nearby Things to Do
An outdoor pool and a spa tub are on site. Other recreational amenities include a health club, a sauna, and a steam room.
Spa Services
Guests can pamper themselves with a trip to the onsite spa, which has 8 treatment rooms. Services include massages, body treatments, and manicures and pedicures. The spa is equipped with a spa tub. A variety of treatment therapies are provided, including aromatherapy.
- Number of treatment rooms 8
- Manicures and pedicures
- Aromatherapy treatments
- Spa tub in spa
- Massages
- Body treatments
Hotel Policies
Check-in time starts at 2 PM
Check-out time is noon
Payment types
Children and extra beds
- Children are welcome.
- Kids stay free! Children under 11 years old stay free when using existing bedding.
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
- No onsite parking is available.
Optional extras
- Airport shuttle fee: USD 30 per vehicle (one way)
Hotel Name
- Hotel Palace Saigon
- Palace Hotel Saigon
- Palace Hotel Saigon Ho Chi Minh City
- Palace Saigon
- Palace Saigon Ho Chi Minh City
- Palace Saigon Hotel
- Saigon Palace Hotel
We should mention
Children 11 years old and younger stay free when occupying the parent or guardian's room, using existing bedding. Only registered guests are allowed in the guestrooms.


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Connect With Us800-299-9470
This Sofa Sectional & Chaise from NOVO Home by SLR International adds modern appeal and seating space to your living area. Place in a corner or float in the center of your room to create a stylish yet functional seating group when entertaining family and friends. The Eco-Leather RF Chaise 2PC Sectional features a kiln-dried hardwood frame that is cornered blocked, glued and reinforced, to offer strength, while the sinuous, no-sag spring suspension base provides a supple seating experience that will hold up for years. Pocketed Coil Spring seat cushions are comprised of a high density foam cushion wrapped in polyester fibers to ensure a comfortable, relaxing and lasting seat. Baffled back cushions are individually bagged to prevent sagging and the Pirelli elastic webbing back suspension offers additional stability to ensure years of comfort and enjoyment.
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Nylabone DuraChew Bacon Flavor Bone Dog Toy
By Nylabone
|List Price:
|$7.99 & FREE 1-2 Day Shipping at $49
|You Save:
|$2.00 (20%)
In Stock
- X-Small
- Small
- Medium
- Large
- X-Large
Product Description
In the history of language, there have never been three words more perfectly combined to bring joy to any pup: bacon bone chew. Durable Bacon Bone Chew Dog Toys from Nylabone keep busy chompers (and happy taste buds) busy with a tough nylon material that tastes like bacon. As your best pal gnaws, it raises bristles that increase chewtime happiness, cleans teeth, and freshens breath - all at the same time!
Key Benefits
- Tough design made for powerful chewers
- Cleans teeth, freshens breath, and promotes oral health
- Satisfies chewing desire
- Made in the USA!
- Available in multiple sizes
- X-Small (Petite): Dogs up to 15 pounds
- Small (Regular): Dogs up to 25 pounds
- Medium (Wolf): Dogs up to 35 pounds
- Large (Giant): Dogs up to 50 pounds
- X-Large (Souper): Dogs 50 pounds and over
|Item Number
|Breed Size
|Country of Origin
Pet lovers who bought this item also bought...
Important Information
Nylon, natural flavor (non-meat based)
Customer Ratings & Reviews
Rated 4.4 out of 5 by 129 reviewers.
Rated 4 out of 5 by Deb70 unsure how this chew treat will hold up This is my first Nylabone purchase. I have a pit mix who can destroy any "tuff" toy in seconds, but so far she is enjoying working this one. She has not been able to break off any large pieces yet. I watch her progress on it. She seems to like it overall and keeps her busy while she suns in the backyard. May 6, 2015
Rated 5 out of 5 by TucsonJane It's true- it's stands up to my powerful chewers So far so good. I'm actually amazed. My dogs usually have destroyed a chew toy by now. It's been three weeks and they're still in one piece. The ends are showing chew marks and wearing down. But toys are usually in the trash the first day or they're not interested in them at all. I have a 15 yo 50 lb pittie, a 3 yo 55 lb heeler mix as well as a 2 yo 10 lb terrier mix. They all love these. February 15, 2015
Rated 5 out of 5 by ELDogTrainer Bizarre concept but it works Why would dogs chew on nylon??? I have no idea why (I didn't test it out myself to see if it really tastes like bacon) but it does help clean teeth, freshen breath and funny enough, all my dogs and foster dogs love chewing them. December 9, 2013
Rated 5 out of 5 by Linda61 tough bone for tough chewers I own a 60 lb lab and a 60 lb pit mix. We've only had the bones for a couple of days, but so far I think they're gonna hold up to the The pit mix is a very powerful chewer. December 26, 2014
Rated 5 out of 5 by TannerBear Cheaper than Petsmart My dogs love these bones and they are cheaper on this site than when I buy them at Petsmart. November 9, 2014
Rated 1 out of 5 by Sadie414 I can't get my dog to chew it. I have tried these from chewysand other palces, but my dog will not have anything to do with them. May 5, 2015
Rated 5 out of 5 by auntiebonbon must taste great dogs love it all 3 of my dogs like this one, esp our border collie she just lays and chews on it for hours June 23, 2014
Rated 5 out of 5 by BigJen3 Best Chew Toy Best chew Toy ever! Durachew is the best ones to buy for large dogs. I have 3 American Bulldogs that can destroy a toy within a minute. I usually replace them when the edges are worn and ruff. Highly recommended! December 3, 2015


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Thurrock services
|Facilities | Rating | Reviews
|M25 at J30 (southbound) and J31 (northbound)
(also accessible to traffic on the A13, A282, A1090, A1306 and the B186)
|Granada Hospitality Ltd
Granada Service Station
Thurrock Motorway Services Area
(map and directions)
|Telephone number:
|01708 865487
|Signposted from the road?
|As Burger King/Costa/M&S
|Previous operators:
|Grid reference:
|Services type:
|Single site located at a junction.
|Visit Thurrock/Moto's official website
Sitting alongside the M25, Thurrock may not be rich in facilities or modern in design, but it attempts to create a suburban feel by backing on to a large lake.
Main Amenities: Ecotricity Electric Vehicle Charging Point, Full Hou$e, Lucky Coin, NomadPower, Regus Express Workpod, Showers
Restaurants: Burger King, Costa, Eat & Drink Co., Costa Express, Krispy Kreme
Shops: M&S Simply Food, Top Gift, WHSmith
Motel: Travelodge[book rooms]
Forecourt: Esso (with: LPG), Snack and Shop, Costa Express, Krispy Kreme, AdBlue Containers
Parking Prices
First two hours free for all vehicles, after which cars must pay £15 and HGVs £24.50, or £26 to include a £9 food voucher.
Prices are paid using PayByPhone - more details. The location code is 2467.
The fees are strictly enforced by CP Plus.
Before the services were built, a site was considered to the south of the River Thames. It was the first service area to be allowed accommodation from opening, hence the decision to build it into the plan.
When the services opened in June 1992 they claimed to be "the world's most advanced", which is a stark contrast with how they look today. Amongst other things, it held 'customer clinics'... whatever they are!
A couple held their reception at the services after winning a mystery wedding prize from a local radio station. They were treated to several laps of the M25 on a coach.
A 1994 assessment of the services found the turn-in rate to be just 3%, and this was put down to the long detour from the M25.
Refurbishment in November 2006 saw Thurrock gain a WHSmith store as well as a M&S Simply Food outlet, and in July 2012 three new showers.
The Regus Express workpod here was installed in December 2014 - the first Moto site to get a workpod rather than a meeting room.
The filling station here is operated by MRH Group.
Survey Results
In May 2012 and August 2011, Visit England rated the services as 3 stars.
Lord Adonis (Secretary of State for Transport) made little comment on the services when he made a surprise visit in September 2009, saying it had been "greatly enhanced" by the arrival of M&S.
In 2006, Thurrock was graded 3/5 by Holiday Which?
In 2005 and again in 2006, the services won a five star loo award.
|South Mimms (34 miles)
Birchanger Green (M11 north, 32 miles)
|Services on the M25
road becomes A282
Clacket Lane (M25, 21 miles)
Maidstone (M20, 30 miles)
Medway (M2, 27 miles)
Tollgate (A2 eastbound, 10 miles)
Cobham (A2, 12 miles)
|Services on the A13
|Stanford-le-Hope (7 miles)
|Toddington (M1 north, 54 miles)
|Moto services
Medway (M2, 27 miles)
Pease Pottage (M23 south, 43 miles)
Visitor Feedback
Views expressed in these comments are those of the individual contributor. They are moderated by Facebook.


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Police Story 2013
What Did You Watch This Weekend?
- By Rob Hunter
- @FakeRobHunter
- August 4, 2014
The Weekend Watch is an open thread where you can share what you've recently watched, offer suggestions on movies and TV shows we should check out (or warnings about stuff to avoid) and discover queue-filling goodies from other FSR readers. The comments section awaits. I'll get the ball rolling with...
Jackie Chan's 'Police Story 2013' Teaser Promises Gritty Shechanigans
- By Rob Hunter
- @FakeRobHunter
- December 4, 2013
I'll never not be a fan of Jackie Chan. Sure he suffers from foot-in-mouth disease, but as with Mel Gibson and Alec Baldwin before him I've learned to appreciate the art even more than the artist. To that end Chan has provided us with incredible entertainment over the years, often...


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He posts a running countdown of how many days each request has been outstanding, as well as details on the runaround and excuses he receives from city officials.
His goal is to standardize how various departments produce documents and make them more easily accessible to the public "in as few keystrokes as possible," as he puts it. And to do that, he's made lots of Sunshine Ordinance requests, which MOC officials argue are too onerous for them to deal with, particularly given Holmer's lengthy, heavily annotated e-mails, which he fires off to a variety of city departments on a daily basis.
As the many city reps who receive these e-mails will attest, it can take well over an hour to read the entire contents of one e-mail, only to find out it includes enough attachments to keep the reader busy for the better part of a day.
Petrucione and Ragone, who have received Holmer's request for the mayor's daily calendar but not yet answered it, cite the difficulty in figuring out exactly what Holmer wants. However, even the Guardian's simply worded requests for that same information, as well as documents related to the recent health care measure, weren't filled by the timelines set out by the ordinance.
Ragone says his office is just trying to keep up with the deluge of document requests. He raised the possibility of reforms, such as a designated Sunshine Ordinance officer or standardized form, but the MOC hasn't formally proposed any.
Matt Dorsey of the City Attorney's Office is wary of standardizing the system: "I don't think the law should create a barrier — a 'you didn't sign this so I don't have to answer it' situation." SFBG


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JIRA to Task Managers
I used to have a JIRA to Omnifocus Script which fell into disrepair for a bit.
It worked well, but as the Mac modernized itself it ended up with a lot of issues.
So I rewrote it by splitting it into a front-end (JIRA) and back-ends (the different task managers) for Yosemite and El Capitan. Now […]


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Ryle boys' basketball players started hugging, high-fiving and chest bumping each other after the final horn sounded in the 33rd District championship game.
There's more to the story when you become an Insider. WCPO Insider's membership is an additional benefit on top of everything you can get for free on WCPO.com. We created an entire digital organization dedicated to bringing you exclusive access to in-depth stories that you can't get anywhere else, handpicked events, and incredible savings on things you love to do. To find out more click here.
By Terry Boehmker
UNION, Ky. – Ryle boys' basketball players started hugging, high-fiving and chest bumping each other after the final horn sounded in the 33rd District championship game on Friday.
And Ryle first-year head coach David McFarland was right in the middle of the crazy celebration following his team's 60-55 win over Conner in the title game.
Instead of going through a difficult transition period in his first season as a head coach, McFarland will be taking the Raiders to the 9th Region Tournament next week at the Bank of Kentucky Center.
"I just knew if I pour my heart into it and our guys pour their hearts into it that great things would happen," McFarland said. "It's been a fun ride and I'm very honored to be here. Hopefully, we can go to the Bank of Kentucky Center and keep it going."
It did take the Raiders some time to adjust to the new coach. They had a 7-11 record three weeks ago, but they've now won seven straight games and the team's confidence level is soaring.
"Ever since day one, we've worked our tails off in practice," said Ryle senior center Will Stuhr. "It took a lot of sweat to get to this point, but we finally did it."
Stuhr scored 16 points in the district final and was named the tournament's most valuable player. But the Ryle offense doesn't revolve around the bulky, 6-foot-5 center, or any other player for that matter.
The Raiders run a motion offense that keeps the ball moving until any player gets open for a good shot. They did that well enough in the district final to outscore Conner, 44-36, on field goals alone.
"Our guys are so unselfish," McFarland said. "They don't care who scores as long as we score. That a big tribute to our guys and the reason we're able to accomplish things like we did (Friday)."
It was a close game until late in the third quarter when Conner went nearly three minutes without scoring a single point. Ryle made the most of that opportunity and had a 49-43 lead at the end of the period.
Conner had to play most of the third quarter without senior guard Will Ruholt, who scored 15 points in the first half before hobbling off the court with a sprained left ankle. But coach Jim Hicks didn't cite that as a reason for his team's three-minute scoring drought.
"Well, you've got to know that's the Ryle defense," Hicks said. "They really got after us and pressured us hard. They got after our scorers and they didn't let us drive to the rim. And when we did get to the rim, they contested our shots. It was just great defense on their part."
Poor free throw shooting hampered Conner's changes of mounting a comeback in the fourth quarter. The Cougars were 1-for-9 at the line during that period and trailed by as much at nine points (57-48) in the final minute.
"We've never missed nine free throws in a row like that," Hicks said. "And it's hard to win ball games if you can't knock down free throws."
Both district finalists advance to the next round of the playoffs so Conner will be making its first appearance in the 9th Region Tournament since 2008. The draw to determine first-round pairings will be held either Saturday night or Sunday morning.
CONNER 14-18-11-12 – 55 at RYLE 13-19-17-11 – 60
CONNER (11-14): Scott 2 2 7, Way 1 3 5, Ruholt 5 4 17, Lamblez 5 3 13, Hemmerich 5 2 13. Totals: 18 14 55.
RYLE (14-11): Allen 1 1 3, Owens 2 1 5, Puthoff 4 0 11, Bellew 4 0 8, White 6 3 17, Stuhr 5 6 16. Totals: 22 11 60.
3-pointer: C–Ruholt 3, Hemmerich, Scott. R–Puthoff 3, White 2.
ALL-TOURNAMENT TEAM: Ryle – Will Stuhr (MVP), Jake Puthoff, Tanner White. Conner – Sam Hemmerich, Will Ruholt. Boone County – Brenden Stanley. Cooper – Zach McNeil. Heritage – Dan Vargas.


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Video: UFC 157 Open Workouts featuring, Faber, Machida, Carmouche and Rousey with a dizzying leg lock workout.
Originally posted on Fight Hub TV | Last updated 2/21/13
Melvin Manhoef was holding the pads for Lyoto Machida at the UFC 157 open workouts. We could end the article right there and 99% of the world would be satisfied, but if one was to only gush over Manhoef's possible tutelage over Machida's striking, then one wouldn't be able to take in the rest of the sights and sounds of the UFC 157 open workouts. We've been to plenty media events across multiple combat sports, and to deny the buzz in Anaheim's air — Saturday night is going to be special, this much is known, and how could it not be? After months of hype and mainstream media coverage, Ronda Rousey and Liz Carmouche are finally going to step into the Octagon. Supplementing the history in the making, Urijah Faber and Ivan Menjivar will duke it out in a rematch that's been on the boiler for nearly seven years, and of course: Dan Henderson makes his return to the cage after the longest layoff in his career vs. karate man Lyoto Machida. Life is good. Now sit back, relax, and watch Ronda R...
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Become a patron of the Ballet National de Marseille
To promote the artistic excellence and the access to the culture is the business of everyone. Committing with the Ballet National de Marseille means to sign on a citizen step to make the talents live, enhance the artistic education and improve the economic attractiveness of our territory.
Through your donation, you support the programs and actions of the Ballet :
shows' creation
tour organization
educational activities
outreach programs
… While benefiting « a la carte » advantages


text:
Lunapea by GantzAistarWatch
©2013-2016 GantzAistar
A revamp I did of my fursona I had as a kid. She actually has horns too but I left them out, otherwise it would be too busy. And sort of like a deer, her horns fall off and regrow every year. She also owns a little space ship. Hope you like her!
a puss in boots!
waaah this is great !!!
Really fun character design! Love her outfit and her wicked smile and claws.
Sieht sehr toll aus! Die Farben sind sehr schön und ich steh auf ihre Klamotte *_*
Love the style you've used here! Great job.
Whoa!! That's incredible!! Crazy good!!
She's awesome! Very adventure-y!
Ahahah dude she's pretty awesome, excellent design! Love the orange and black fur tufts, and that grin, hahah! The green eyes really pop from the warm colors.
Thank you!!! I actually can't remember what eye-color I used to give her, so I picked this one! Glad you like it!!!
very nice!
I love the design and the color scheme ^.^
I love the design and the color scheme ^.^
wow this is totally awesome. love just admiring the color job.
Der Chara is echt knuffig
Schöne Farben, schönes Design, schöner Stil!
Schöne Farben, schönes Design, schöner Stil!
Vielen Dank!!! War Zeit dass ich sie mal wieder zeichne!
Sassy and adorable!
I like her
She's really cute! I hope to see her and her little space ship soon~


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A jaunty sash helps to create an asymmetrical look on this elegant La Belle 17676 dress. The wrap-style top features straps that meet behind the neck, leaving an exposed back. A matching bolero helps you cover up on chilly evenings.
Find a lower price and we will match and beat it by 5%
We are an authorized retailer of all the dresses we sell. We only sell 100% authentic dresses.
Please refer to our return policy.
Free ground shipping on orders over $50.
Read More


text:
|After-Show Performers
|Music - Feature Stories
|Written by No Author
|Tuesday, 09 August 2005 18:00
Strange Neighbors – 11:30 p.m. Friday night, Quad City Live
A full band and the ability to add pieces at live performances has made Strange Neighbors a must-see act. With three CDs under their belt, Strange Neighbors is hitting the recording studio soon.
Secher Nbiw – 11:30 p.m. Friday night, Rocket
Although you might not be able to pronounce their name, Secher Nbiw is a band you'll want to hear. Secher Nbiw means "golden path" in Hebrew. Their music is based in rock and rhythm with bits of jazz and funk mixed in to round out the sound.
Papa Mali – 12:30 a.m. Friday night, Rocket
Papa Mali covers a wide range of music from roots, soul, swamp, and slide guitar that has allowed him to tour nationally. This solo artist, slide guitarist, singer-songwriter, and producer has performed with Cyril Neville, Anders Osborne, and Jesse Mae Hemphill, to name a few.
David Zollo – 11:30 p.m. Saturday night, Quad City Live
David Zollo surprises most people with his impressive musicianship, which is usually reserved for older, more experienced performers. David began playing the piano at age four and would listen to his father's eclectic record collection. This adds to his keyboard playing, which echoes the greats of country, rock and rhythm and blues.
Bockman – 12:30 a.m. Saturday night, Quad City Live
By unifying the progressive elements of pop, rock, and jazz, Bockman provides a listening experience exclusive only to ears, which crave music. While the music Bockman plays is firmly rock, it certainly reaches into other styles, such as pop and jazz.
Funktastic Five – 11:30 p.m. Saturday night, Rocket
The Funktastic Five have been entertaining the Quad Cities music scene since they began in 2003. The group has recently added female singer Nichole Collins to the lineup to bring her passion to the group's repertoire. The Funktastic Five specialize in a wide variety of covers including Prince and Stevie Wonder.
Free Söl – 12:30 a.m. Saturday night, Rocket
Free Söl formed in 2002 and has wasted no time making a name for itself. Since winning the Mid-South Grammy Showcase in 2002, the group has been performing all across the country. Free Söl's sound is rooted in hip-hop but branches out to incorporate elements of jazz, funk, rock, and soul to create a style they call their own.
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Four people were arrested Wednesday after a stolen vehicle crashed near Estabrook Park near N. Port Washington Road and W. Hampton Ave., Milwaukee police said.
Milwaukee police officers were alerted to the stolen vehicle by OnStar, an electronic vehicle security system, and once OnStar was notified that officers were in the area, the program remotely shut off the ignition, Lt. Mark Stanmeyer said.
The car continued to roll after being disabled and crashed into a light pole about 6 a.m. Wednesday. Four people fled from the car. Three suspects — two boys, 16 and 18, and a girl, 15 — were arrested by Milwaukee police after a brief foot pursuit, Stanmeyer said.
A fourth suspect, a 17-year-old boy, was arrested by Glendale police and was turned over to Milwaukee police.
The car, a 2012 Buick Verano, was taken with keys from the 6900 block of W. Stevenson St. earlier Wednesday morning, Stanmeyer said. The case will be referred to the Milwaukee County district attorney's office.


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Standup Paddleboarders In Wellington Harbor Nz Stock PhotoActivity,Clear Sky,Color Image,Day,Harbor,Horizontal,Leisure Activity,Lifestyles,Motion,New Zealand,Outdoors,Paddleboard,Paddleboarding,People,Photography,Remote,Sunlight,Sunny,Tranquil Scene,Two People,Vitality,Wellington - New ZealandPhotographer Don GrallCollection: Photolibrary © Don GrallA pair of stand-up paddle boarders make their way across the harbor area on a beautiful blue sky day in Wellington, New Zealand


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I want to set compilation debug="false" to get release mode dll's compiled on the fly from aspx files.
However, I still want line numbers and such on errors as you find when you compile a DLL project with pdbonly set.
If you're looking to do that, you can find a great answer on this question: http://stackoverflow.com/questions/628565/display-lines-number-in-stack-trace-for-net-assembly-in-release-mode
Any ideas?


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PHOTOS: Destruction in Washington, IL
A tornado that touched down in Washington, IL Sunday afternoon has caused unbelievable destruction. Photos courtesy of Anthony Khoury via Twitter.
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ANAHEIM – A small crowd that included family members gathered under a funeral tent at Anaheim Cemetery on Monday to pay tribute to a man who valiantly fought for his country – 200 years ago.
A wreath was set at the foot of a large stone monument topped with a cross that marks the final resting place of Ezra Benedict Kellogg, a veteran of the War of 1812 and, later, an Episcopal minister who help found St. Michael's Episcopal Church in Anaheim.
Kellogg, who died at 83 in 1878, is believed to be the oldest veteran buried in Anaheim.
He's among only eight veterans of the War of 1812 buried in California, according to Anne Scholz, president of the National Society United States Daughters of 1812, based in Pacific Palisades.
Scholz and others invited Kellogg descendents to pay help tribute to the veteran on Monday – the 200th anniversary of the start of the war against British forces.
"It was the forgotten war in many ways, the war that really solidified this countries' independence and freed us from the occupation of British forces," said Scholz, 78.
The war lasted nearly three years and resulted in peaceful relations and open trade with Britain.
Kellogg, who served in Ohio and later moved to Anaheim, was a "beloved patriot" whose memory should live on because "nothing is really ended until it is forgotten," Scholz said.
The Daughters of 1812 learned about Kellogg's grave from Anaheim resident Barbara Tan, who came across a 1966 Anaheim Bulletin article about a bronze marker being installed to commemorate Kellogg's service. Tan contacted Scholz – who invited family members living in the Eagle Rock area of Los Angeles.
They included John Zimmerman, 80, a Korean War veteran and second-great-grandson of Kellogg and two Zimmerman daughters, Beth and Evelyn, who also served in the Army.
"He believed in family, country and freedom, and I think it's important to remember him, to keep (his memory) alive," said Evelyn Zimmerman, 51. "I have a nephew serving in the Army now, and I think it's equally important that we pay tribute to everybody who is serving or has served."
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