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Search Engine Optimisation
Although Search Engine Optimisation (SEO) is a tried and tested formula, it is not what it used to be. Trends are constantly changing and the way in which search engines determine your company's relevance (in terms of rankings) are, in some ways, much more ambiguous. High quality content and engagement is crucial, as well as genuine optimisation.
This is where we step in, as consultants we work with you to employ new and creative strategies to help boost your company's positions in search engine rankings, therefore increasing your exposure to the online market.
One comment
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London" was indeed really good! I actually can see eye to eye with you more!
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Ryan McGinness recently opened his solo show in Madrid entitled Studio Franchise. Separated into three sections, the show started with a replication of his New York studio, following into a studio full of work in progress and lastly ending with finished works on the wall. Slightly stabbing at the 'new cycle' of a modern artists, Ryan McGinness touches on the "Warhol factory sarcasm, the Koons/Murakami/Hirst factory sincerity, and the artist-as-brand reality of today."
To compliment the exhibition is a book called "Studio Manual", again, prodding at the re-occurring theme of the commercial approach to re-creating an artist, or in this case, Ryan McGinness.
See inside exhibition 'Studio Franchise' by Ryan McGinness below.
Images Creative Review

subset: commoncrawl


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Champions Online Blood Moon Event Returns
The Blood Moon rises once again in Champions Online hailing the return of the Undying Lord Takofanes.
The Blood Moon has once again risen over Millennium City and the Undying Lord Takofanes has once again returned to cause trouble in Champions Online. The special Blood Moon event gets underway today and will continue through Monday, Oct. 15. During that time, players can join a number of events that include zombie invasions, missions to slay undead heroes and face the Undying Lord Takofanes. A number of rewards and a new perk will also be available during the event.
The Blood Moon event will also return later this month as Halloween approaches.
To read the latest guides, news, and features you can visit our Champions Online Game Page.


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What does BCIS-NT stand for?
What does BCIS-NT mean? This page is about the various possible meanings of the acronym, abbreviation, shorthand or slang term: BCIS-NT.
We've found a total of 1 definition for BCIS-NT:
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Battlefield Combat Identification System -Near Term
Still can't find the acronym definition you were looking for? Use our Power Search technology to look for more unique definitions from across the web!
"BCIS-NT." Abbreviations.com. STANDS4 LLC, 2016. Web. 9 Feb. 2016. <http://www.abbreviations.com/BCIS-NT>.


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Comment guidelines: Please be respectful to other people when making comments on this page. Bullying and abuse will not be tolerated and may result in your account being banned. Due to feedback from our user community, comments are now only available to registered users.
Register to update information, save favorites, post photos, news stories and comments.
Sara Nuru (born August 19, 1989 in Erding, West Germany) is a German fashion model. She was the winner of the fourth cycle of Germany's Next Top Model.
List of links to Sara Nuru fansites:


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Product Description
This listing is for a digital print of a Bioshock Infinite poster that I designed. Printed on premium archival photographic paper.
It is available as both 11×17 and 18×24 inch prints. Bioshock Infinite poster.
All posters are shipped rolled in a poster tube via the USPS. US orders are shipped free via First Class Mail, with an option to upgrade to Priority Shipping. International orders are shipped via First Class International Mail.
Since all posters are printed after they are ordered, please allow 3 – 10 business days for your order to be printed and shipped.
If you have any questions, please contact me.


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Imagining Architecture
Fantastical architecture, imaginary urbanism, and hallucinatory dwellings.
2. Rakkóx the Billionaire & The Great Race, by Paul Scheerbart
3. The Cathedral of Mist, by Paul Willems
Imagining Science
Outsider science, extreme empiricism, aberrant experiments, and imaginary speculations—literary explorations in fictional science.
2. The Perpetual Motion Machine: The Story of an Invention, by Paul Scheerbart
3. The Hierarchies of Cuckoldry and Bankruptcy, by Charles Fourier
4. Pataphysical Essays, by René Daumal
5. The Pig: In Poetic, Mythological, and Moral-Historical Perspective, by Oskar Panizza
6. The Table, by Francis Ponge
The Library of Cruelty
Tales of love, crime, war, and madness, from the surreal to the sarcastic.
2. The High Life, by Jean-Pierre Martinet
3. The Book of Monelle, by Marcel Schwob
4. The Conductor & Other Tales, by Jean Ferry
5. Flametti, or The Dandyism of the Poor, by Hugo Ball
6. The Creator, by Mynona
7. The Emperor of China, The Mute Canary & The Executioner of Peru, by Georges Ribemont-Dessaignes
8. A Dilemma, by Joris-Karl Huysmans
9. Disagreeable Tales, by Léon Bloy
10. The Trumpets of Jericho, by Unica Zürn
11. Exemplary Departures, by Gabrielle Wittkop
12. Murder Most Serene, by Gabrielle Wittkop
13. A Terrace in Rome, by Pascal Quignard
14. Sweating Blood, by Léon Bloy
Verse, from the adverse to the perverse.
2. The Massacre of the Innocents, by Giambattista Marino
3. Life in the Folds, by Henri Michaux
Wakefield Handbooks
The how-to manual reimagined: guidebooks on a variety of satirical, parodic, and quixotic subjects.
2. The Young Girl's Handbook of Good Manners for Use in Educational Establishments, by Pierre Louÿs
3. A Handbook for the Perfect Adventurer, by Pierre Mac Orlan
4. The Physiology of the Employee, by Honoré de Balzac


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Skip to content, or skip to search.
Skip to content, or skip to search.
132 First Ave.,
New York, NY 10009
Mon-Thu, 8:30 am-2am; Fri, 8:30am-4am; Sat, 10am-4am; Sun, 10am-2am
4pm-7pm; ½ off all well drafts, bottled beers, and glasses of wine
6 at Astor Pl.
Discover, MasterCard, Visa
Open early in the morning until late in the evening, VBar St. Marks is a quaint café and a trendy nightspot in one. Wine and beer selections co-exist along the bar with an old-style espresso machine, and the high-backed chairs play host to everyone from laptop-toting freelance bloggers to scruffy hipsters. Décor is sparse; there's a Tattoo You cover prominently displayed amidst the exposed brick, large windows, and dark lacquered tables. The menu shifts from coffee and pastries to Sardinian-inspired lunch, brunch, and dinner options.
Picnics with a view, roller-skating nostalgia, and a party for gay headbangers.


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Tags: nice, talented, girl, performs, amazing, blowjobs, 50, men, porn stars
Pornstars: Jenna Red
Submited: 6 years old
Views: 2353
Copyright © 2006 - 2016 DeviantClip.com - All Rights Reserved.
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Nice Talented Girl Performs Amazing Blowjobs On 50 men.


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Top 10 Ribs in Toronto
By: Jennifer D'Agostino , Nelson Tam
Posted: June 22, 2015
Posted: June 22, 2015
Meat n' bones, and eating with your hands – it's no wonder ribs often comes up as a top food choice of eaters everywhere. And with nicknames like Hogtown and The Big Smoke, Toronto is a natural home for some superb BBQ. Here are ten of the city's rib plates you should consider trying.
More Where to Eat in Toronto
- Top 10 BBQ Places in Toronto
- Best Gelato in Toronto
- Top 10 Burgers in Toronto
- Best Brewery Tours in Toronto
Top 10 Ribs in Toronto
Marky's BBQ Smokehouse:…
The ribs from Marky's BBQ…
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Aft Kitchen & Bar: Ribs
We try the ribs at Aft Kitchen &…
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Universal Grill: Ribs
We try the ribs at Universal Grill.
Read More
Big Crow: Ribs
We try the ribs at Big Crow.
Read More
The Stockyards: Ribs
We try the ribs at The Stockyards.
Read More
Lou Dawg's: Ribs
We try the ribs at Lou Dawg's.
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Triple A Bar: Ribs
We try the ribs at Triple A Bar.
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We try the ribs at Smoke Bourbon…
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Voluptuously Fudgy One Bowl Gluten Free Brownies
Yup. I did it again. I made up my own recipe dang it. Why? Because I think that gluten free recipes are overly tedious. Certain things like gluten free puff pastry will be tedious even if glutenized. Brownies shouldn't be. It should be a simple luxurious treat.
I've done a lot of gluten free experiments lately like gluten free pizza and gluten free banana strawberry muffins. They came out beautiful….if not better. But lets talk turkey here. Pre-packaged gluten free bake goods are crap for the most part. Pre-made gluten free bread is like choking down sand. I honestly don't understand it. Thinking logically if bread is done correctly it shouldn't be grainy. It makes me think that gluten free bread is not the problem but the manufacturer is.
So far I have tried a few different brands of flour. Heck, I even mixed up my own. The unfortunate part of it all is the expense of the flour. Considering the fact that I don't have to spend my days in misery exceeds any negative thoughts to the expense of gluten free products. But really its not that bad. Arrowhead Mills Gluten Free All Purpose Baking Mix can be used for muffins, cakes, breads, pizza and cookies. It does have baking powder in it as well as salt so take that into consideration. Think of it as like regular all purpose flour.
So I looked up a ton of gluten free brownie recipes just to make sure I wasn't missing anything. A common misconception is that fudgy brownies are because of flour. Nope. Wrong. Its the amount of egg you use. You never will get a fudgy brownie with out the use of eggs. The more egg you use the more fudgy and vice versa. You would not believe how complicated some of the gluten free brownie recipes are. It was laughable. Just replace flour with the gluten free all purpose flour and presto: gluten free brownie magic.
Gluten Free Brownies by The Home Made Cook
- 3/4 cup real butter, melted
- 1 1/2 cups of sugar
- 1 1/2 tsps of pure vanilla extract
- 3 large eggs, room temp
- 3/4 cup gluten free all purpose flour
- 1/2 cup of baking cocoa (the better the chocolate the better the brownie…you can sub out the cocoa and butter and just use unsweetened chocolate)
- 1/2 tsp baking powder
- 1/2 tsp salt
- Preheat oven to 350 F.
- Grease 8 or 9 inch square pan.
- Combine all dry ingredients evenly in large bowl.
- Add melted butter and stir until incorporated
- Add eggs one at a time and whip with a whisk until glossy and thick.
- Add vanilla until incorporated.
- Pour brownie batter into pan and bake for 35 minutes or until cake tester comes out clean.
- Enjoy!


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Black and Yellow iMac by monkeymagicoWatch
©2010-2016 monkeymagico
Minimal imac wp
Nice shade 0f yellow, great job.
wow.. i never would have thought that a plain yellow wall would look good on anything, but looking at it now on my LED iMac screen is making me totally change my mind.
vibrrrrrant, man!!
vibrrrrrant, man!!
Thanks v m O I couldn't help it - inspired by the work Swiss design god Joseph Muller Brockman


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Thursday Morning First Alert Forecast July 18UPDATED 8:37 AM EDT Jul 18, 2013
Felicia Rodriguez says it will be another rainy day before it begins to dry out in time for the weekend.
More Video
CommentsThe views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.blog comments powered by Disqus


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Maytag Quiet Series 200
The owners guide download of Maytag Quiet Series 200 related with available for free. We acquired the portable document format from www.comdac.com purposes as setting to help you to resolve your problem.
PDF Summary : Jul 2, 2005 Sofsound Iu2122 Quietseries U2122 200 Sofsound Iiu2122 Quietseries U2122 300 Quietseries U2122 300 High Temp Wash X X X X X Electronic Controls X
Maytag Quiet Series 200 Posted at April 18th, 2013, read and download online using button that we provide below :


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Giratina by KitWhithamWatch
©2010-2016 KitWhitham
A violent creature that lives in spirit world, the world reverse of ours. It was banished to this Reverse World for its violence. Now it silently gazes upon our world, waiting for a chance to return.
A redesign of Giratina, meant to look more realistic and frightening.
EDIT: Darkened the colors. Should be easier to see now.
A redesign of Giratina, meant to look more realistic and frightening.
EDIT: Darkened the colors. Should be easier to see now.
very cool concept to change up giratina.
My minds: "Slenderman?")) Cool art)) I wanna draw like THIS...)) ^^
Y'know, one other person compared this to "Slenderman", though I still don't know what "Slenderman" is.
thats pretty sick haha
He reminds me a little of Venom Myotismon.
Wow! That's the best looking form any pokemon has ever had... but I wouldn't catch because I it doesn't look reliable... btw, thanks for being the first one to comment on my stuff.
No prob, thank you for the faves and watch!
Well, you have good stuff there and I want to see when you make new cool drawings. Monster Hunter Tri is possibly my favourite Wii game and I like pokemon too...
Monster Hunter Tri-one of the best games ever. Pokemon-i grew out of that a long time ago, but it's interesting trying to make them look realistic
that is the most epic representation of Giratina I have yet to ever see.
ZOMG very epic interpetation of giratina. I like it!
I love the way you did its wing/leg/spike/things! Lots of motion here.
Are you going to color it in completely?
Are you going to color it in completely?
Well i've tried, but i can only do so much with colored pencil. I tried to give the rest of the pic an errie, spirit world feel, but i'm kinda out of practice when it comes to coloring.


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I love checking out videos posted in Youtube, and videos shared by my friends in Facebook. I got so addicted to all the fun, reality videos; and the series posted at Red Chair Confessions got me so intrigued.
I thought these are ads for a new condom brand or a family planning campaign. And then, there is an epiphany! We are dealing with shopping, and shopping addiction. The girls on the videos are just going crazy over Talbots! Who would have thought?
I couldn't blame them. I know exactly how it feels to be addicted. You can check my previous posts for rants and raves. Besides, Talbots is having a make-over. It is no longer a shop for your moms and aunts. The store ditched the boring simple cuts and plains; and is now offering pieces for every age bracket. Check out the site and lure to every hip and stylish pieces they are offering. Let me know which ones are you favorite and leave them on the comment box. You want to know my picks? Check out my entry here when I virtually shopped at Talbots.
Check out the Red Chair Confessions now and share your own confessions! We do not need to go to the church to confess and ask for forgiveness. Shopping is therapeutic. No guilt feelings please.


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I had said it many times how good the Street is, however, I must admit that it takes the arrival of another bike in order to fully appreciate the value of one you already have! As mentioned above there was this reluctance to take the Street for a long ride, for the fear of excessive back pain as result of forward leaning position.
Since having the Bonnie, I had already undertaken a two series of long ride to the North on it(read the review here). It was fine with the exception that the Bonnie is 'happier' to be ridden rather gently, and best to stay at or below 160km/hr. You can push it to 170/180 (its not that I do it regularly you know…) but it would be a hard struggle and impossible to keep even at 160km/hr for too long. Another is it's slightly less agile due to the rigid suspension, sometimes you loose that feeling of harmony with the bike, when the rear tire feels sort of waning a bit once you do an extreme manouver like switching lane aggressively. When you need that performance ride and the extra umphh then the Street is the definite choice.
I was right, and once I made up my mind to take it for a long ride to Trengganu – I was fully satisfied, indeed the STreet gave more than I expected.
Taking the Challenge
I was set to accompany two friends to Kota Bharu, as part of their journey across the border with the rest of MIB team. I did not join the trip due to local commitment. They were the two riders who could not join the team who have left earlier in the morning. Then, as we met at the RV point at BHP Gombak, we found out that the other guy, KZ had to cancel due to pouring rain in his area at Shah Alam. Initially we were quite taken aback, but thinking about it, then I thought there is no way we can force people to ride (despite the weather), we can force someone NOT to ride, and not the other way. So, I was left with no choice, have I not gone ahead to accompany R, there would be a strong possiblity he will back off, and I could be the guilty party then.
I had a meeting early morning the following day. The wife just left with two kids to the camp, means, my other two kids are left at home overnight without big adult…means, I have to come back home by hook or by crook. Thinking about the prospect of riding over 400km and then turn back home, alone, made me almost sweat…knowing the brothers in MIB, they will most likely advise against doing it for safety. So I was torn in between.
So I made a deal with R, I will not be able to ride all the way to KB, but I shall accompany him to a point he feels comfortable to proceed. And to him, its Kuala Berang, near his home town, where he will have the opportunity to rest there, or proceed to KB if we arrive early enough. And Kuala Berang is just over 400km away!
We began the journey around 3.30pm after a cool lunch and refuelling. I was riding the Street and R his Sym Evo 250i, what a missmatch you may think. Knowing R, he is such an efficient rider, at open highway he will ride at constant speed of 130km/h plus, but thrown into a traffic congestion he is the king, and will not waste a second to project himself ahead of others. However today, for some reason I initially did not know, he decided to keep himself at a lower speed below 130. That was pain (oops).
Huh….as the Street began its cruise along the Karak highway, I kept at 4th gear, anticipating series of corners ahead, I started to feel restless. Not a few seconds pass and R was nowhere can be seen behind. Never mind I thought, he will catch up when I got to those tight bends – since I am quite hopeless with them. Suddenly just as we approached Genting Sempah, I saw vehicles slowing down as a long que started to build up. I had just begun enjoying the corners with this 'new' approach when the traffic came to a halt. I was caught once when I tried follow the emergency lane (gravels and soils on the road, waited clearance to join the first lane gap, and R quickly launched ahead leaving me struggling with lane splitting behind.
Not long after the congestion started to ease off. I must say the STreet is well capable of tackling those tight gaps, but I am talking about tackling it at high speed, of course a no no when met with mixtures of tailgating plus tight corners, no choice but I had to take it easy. Once I was clear, I began squeezing the throttle fast, the machine just complied with no sign of stress at all. Now comparing with the Bonnie, it was a breeze to enjoy streaming at 160-170 or 180plus (occasionally) smoothly. Yup, its such a muscular machine, and I felt comfortable despite the foward leaning position. In fact the position is ideal for dealing with wind and high speed riding. In no time I caught up with R and took the lead again.
At one point I was overtaken by this Z1000x I thought, I quickly caught up just to remain closely behind the rider, maybe he realised he was being followed. When it came to tight gaps, I felt I could do better and once freed, I squeezed the throttle hard almost to full, very close but I decided not to overtake him, I know he owns a more powerful machine! no wonder the guy is riding a litre bike which is no match to my Street, though almost! (Well I supposed, the game would have been entirely his when we come to corners huhu).
How does it compare to my Bonnie T214?
Most amazing, comparing to the Bonnie, both being naked bikes, the STreet did far better at higher speed. At 140 cruising is a doodle, you hardly feel the wind resistance (keeping in mind my Bonneville has no windshield yet). Even stepping up to 160, 180 is a gem, and the humming sound when you get beyond 150km/h is seductive. In contrast to Bonnie (quite viby at high speed), steady ride at 160 is a pleasure, I could squeeze to 170 and beyond without feeeling any vibration or instability, yes a confidence steady ride at such a speed, as long as I am on a stright line. On a high speed corner, it is possible to maintain a 150 plus without any trouble. Ooops, I forgot about my friend, now I definitely could not trace his shadow…so I had to practically stop on the roadside and wait. That was good, coz i could take the time to stretch out, walk back and forth straighten my back and exercise my neck. 160km on, I stll felt good.
We took two stops, one at Gambang, and another … not another. From Gambang it was a straight long, almost boring ride. R said we could go all the way pass Kuantan, but I almost made mistake at the Kuantan Tol booth when R came behind signalling me to make a U turn which took us back to the LPT (I was slow enough then R could see me). From then on, straight ride till we reached the Kuala Berang exit. My fuel reserve indicator had long come up but I managed to keep going and the reading was 220+ when I reached the refuel station.
Home with happy mileage…
We stopped for maghrib prayers and then made a U turn and ate at a nearby restaurant – simple menu (that took a while to arrive!) consisted of fish Tomyam and Kailan ikan masin. Due to the long waiting, it took us a total of 90 minutes or more rest before started riding again. By now R had decided that he is ok to go alone, indeed he was near his house, but proceeded straight to Kota Baru, which was just over 180km. I headed back to KL which was another 400km plus, alone.
Now this is the most challenging part of the ride. Riding at night, a long straight ride, and it began to rain. God knows how nervous I felt in the beginning. One of the MIB members asked on the Whatsapp group how I plan to spend the night. I left the question unanswered.
Riding gears on, I started the bike, ahead of R, we both headed the same direction till the beginning of the highway that separated us according to the direction. I bid farewell to R & prayed to God for his safety. Just as I about to enter the highway, there were a number of young guys riding RXZ acting suspicious as if they are going to rempit. I speed away and did not see any sign of them again. Now onto the highway, I felt warm and my confidence grew. Amazingly I did not feel tired, even after that long ride. My back felt normal, though my neck hurt a bit. I built up the speed, 140, 160 plus…and the bike kept going nicely. Then came to the unlit part of the highway, I suspiciously slowed down a bit, when the ran began to pour quite heavy. I had to take it easy this time indeed quite a number of time I just kept it at 120-130km/hr. Being a naked sport, its not easy to keep a constant speed, and despite the rain I could not avoid passing the 130 mark. In total I travelled under the rain for almost one hour, covering over 100km of highway, when the weather began to get clear. Now I was on to the better part of the highway, though most part were still unlit – which I despised this shortfall. My aim was to reach Gambang, distance in total about 220km. Now I kept to a constant speed between 140plus to 160, or more sometimes especially when coming to a well lit area I could squeez more juice out. The road was rather quite in most part, that was not very desirable, since I had no clue what it was like, except that I had to rely on my own vision. My eyes fully focused on the road and surroundings, watching for any signs of puddle or any unusual objects. It is known that sometimes animals like monkeys or foxes could cross the road at this time, and I am definitely not going for the kill or else I would be the one troubled.
Off to Gambang, there was jubilation and excitement, knowing I only had less than 200km to go. I rested a bit, drank coffee, refuel and check tyre pressure before resuming my journey.
Gambang KL was much more civilised with the traffic began to build up once I passed Karak tol. The worst part was tackling the curves in total darkness, I almost gave up, slowed down a lot and only picked up my pace when the lighting got better. I kept wondering how the authority have the heart of leaving such dangerous bendy road unlit, in fairness it is not very safe even for cars and other vehicles. All I could do was slow down and refuse the temptation to follow other, more experience or daring riders. Passing Bentong there were better lighting and I felt more confident going at speed. The rest of the journey was smooth and thank God, I arrived after spending in total about 3 hours 40 minutes (including stops) of return journey.
Arriving home, it was all for a happy ending after breaking the record of doing over 800km ride within a day!


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Music blog
Johnny Depp Gone Mad Apocalyptic Z Anime Comes Out Of Shell Absolute Magic Of Rickman's Voice MORE ›
Lyrics/song texts are property and copyright of their owners and provided for educational purposes only.
I Pledge Allegiance to The Band... Lyrics
I Pledge Allegiance to The Band... Song Lyrics
Well you wanna get rid of me? Why, because I'm old?
You hate teachers? Is that what you're about?
Well teachers like to play too and not only am I gonna play, I'm El Capitano.
And what I say goes, so put your
hands over your hearts. I pledge allegiance,
I pledge allegiance,
To the band,
to the band,
Of Mr. Shneebly,
of Mr. Sneebly,
And will not fight him,
and will not fight him,
For creative control,
for creative control,
And will differ to him on all issues related to the musical direction of the band,
Let's Go!
[Thanks to email@example.com for lyrics]
School of Rock Song List
›School of Rock
Jack Black
›Your Head, Your Mind, Your Brain...
Jack Black
The Who
No Vacancy
›Touch Me
The Doors
›I Pledge Allegiance to The Band...
Jack Black
›Sunshine of Your Love
›Immigrant Song
Led Zeppelin
›Set You Free
The Black Keys
›Edge of Seventeen
Stevie Nicks
›Heal Me, I'm Heartsick
No Vacancy
›Growing on Me
The Darkness
›Ballroom of Mars
T. Rex
›Those Who Can't Do...
›My Brain Is Hanging Upside Down
The Ramones
›T.V. Eye
Wylde Rattz
›It's a Long Way to the Top
Jack Black
›Math Is A Wonderful Thing
Jack Black
I Pledge Allegiance to The Band... Lyrics by Jack Black from School of Rock Soundtrack (2003). Rating: 4.2/5 (29 votes)


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hillas attack by muuraWatch
©2011-2016 muura
If there was a magical fighting game that looked like this....
My dearest wish is a magical girl rpg/action/adventure game for ps3 or something with really awesome glittery shiny rainbow graphics ;_; wwwhhyyy is there not one yettttt
Oh! Ah! So lovely!
Jollain tavalla mukavan vauhdikasta menoa jokaisessa. Ylimmäinen oma lemppari. :>
poses ftw!
Oooh I wanna try these kinds of perspectives as well. Did you just make up these kind of warped angles in your head, or have you used some kind of certain technique? Any advice? :3
Oh maaaan I just made it all up.. I guess my tip would be to be as loose as possible and not think about it too much.. which is a lousy tip to be honest........... but just knowing that objects become bigger the more they approach the viewer is a good basic to go from?? Aaaand I'm just exaggerating it a lot so nobody actually notices I don't know what I'm doing lmao
Haha, I'm more than satisfied with that answer. I was afraid one had to struggle with fisheye lenses or perspective grids or something to get any flow in this tequnique. (Me and correct perspective grids are like a eight year old and medicine. I know it's good for me, but I keep sulking over it and forget it on purpose.)
lovely colors and perspective!
The perspective looks really good on all three drawings! I really Love that controlled messy looking coloring style and really loose lines.
Thank you thank you! Perspective is what I had in mind while doodeling these, I guess I got bored with drawing nothing but static shit all the time.. gonna flex the perspective-hand when I get around doing the 24hour comic next weekend..!
Oh! well then good luck then! I'll be looking forward to seeing your comic if and when you put it up!
Cool stuff! I love how dynamic and fun these are!
uguu these are BEAUTIFUL. @_@
how do you make so much MAGIC! **sparkly eyes**
These were actually powered by frustration lmao
Keskimmäinen on niin upee et mä nuolasin tota jalkaa! Eli siis näyttöäni 8I
OIH sinä jalka fetis tisti
Siisti toi katsojaa lyövä jalka.


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February 7, 2016
Pet Talk: So many dog attack stories, but do you really know what makes a dangerous dog? Is it just the breed or is there more to it, even if it is a pit bull? Our experts chime in this morning. If you need information on the puppies up for adoption you can contact the Red River SPCA at 940-668-6714. More pet facts at www.shojai.com
Click Here to access the online Public Inspection File
Viewers with disabilities can get assistance accessing this station's FCC Public Inspection File by contacting the station with the information listed below. Questions or concerns relating to the accessibility of the FCC's online public file system should be directed to the FCC at 888-225-5322, 888-835-5322 (TTY), or firstname.lastname@example.com.


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Twins win pitchers duel
KANSAS CITY, Mo. (AP) — Kyle Gibson bounced back for a rocky start to shut down Kansas City, and the Minnesota Twins held on through a shaky ninth to beat James Shields and the Royals …30 Jul 14
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KANSAS CITY, Mo. (AP) — Kyle Gibson bounced back for a rocky start to shut down Kansas City, and the Minnesota Twins held on through a shaky ninth to beat James Shields and the Royals …30 Jul 14
MINNEAPOLIS (AP) — Sam Fuld hit a tiebreaking, two-run single off Javy Guerra in a three-run seventh inning, and the Minnesota Twins defeated the Chicago White Sox 4-3 Sunday to avoid a four-game sweep. Danny …28 Jul 14
HOUSTON (AP) — Former baseball star Chuck Knoblauch has been charged with misdemeanor assault after authorities in Houston say he hit and pushed his ex-wife. Knoblauch has been released on $10,000 bond. His first court …25 Jul 14
MINNEAPOLIS (AP) — The Seattle Mariners have reacquired first baseman Kendrys Morales in a trade with the Minnesota Twins for minor-league pitcher Stephen Pryor. The deal was done Thursday. Morales spent under seven weeks with …25 Jul 14
MINNEAPOLIS (AP) — Hector Noesi allowed three hits over 7 2-3 innings and Adam Eaton had three hits and two RBIs to lead the Chicago White Sox to a 5-2 victory over the Minnesota Twins …25 Jul 14
MINNEAPOLIS (AP) — The Minnesota Twins have designated right-hander Matt Guerrier for assignment and will recall right-hander Ryan Pressly from Triple-A Rochester to take his place in the bullpen. The move was made Wednesday. The …24 Jul 14
MINNEAPOLIS (AP) — Anthony Swarzak pitched five sharp innings in a fill-in start, Oswaldo Arcia homered and the Minnesota Twins beat the Cleveland Indians 3-1 Wednesday. Danny Santana scored after two of his three hits …24 Jul 14
MINNEAPOLIS (AP) — Carlos Santana homered among his season high-tying four hits and Danny Salazar won in his first start in more than two months as the Cleveland Indians beat the Minnesota Twins 8-2 Tuesday …23 Jul 14
Check out our Sports Broadcast Schedule! From the Twins, Wild, and Vikings to your local High Schools or Amateur Baseball teams, we've got you covered right here!


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- Sheena Ancient Arches Embossing Folder 5x7"
Product Description
This embossing folder called "Ancient Arches" is perfect for all of your papercrafting, cardmaking and scrapbooking project. This embossing folder can be used in most leading bran embossing machines and is great for scrapbooking, embellishing, and much more if you're looking for an easy way to add texture and style to your paper and cardstock projects then this embossing folder is for you. This embossing folder measures 5" x 7".
- Beautiful and Detailed embossing Folder
- 5x7"
- Use with most pressure-based embossing/die cutting machines
- Use it, ink it, Brayer it!, use with coated paper & sand it!
- Unlimited creative potential!


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Denise Milani - Black Brain Denise-Milani, by itzikgurWatch
©2011-2016 itzikgur
photomanip of Denise Milani with a Black Bra
sexy masturbate lady
Gracious, that bra's holding on for dear life!!
sexy babe
Lookin' good girl!
honestly I do not like is breasts because they are too big now hangs. Environments are more beautiful breasts.
"Earth Angel, Earth Angel, Will You Be Mine"
whooa r those real ?


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The Texas Council on Family Violence (TCFV) and the
Texas Association Against Sexual Assault (TAASA) are pleased to announce
their collaborative prevention conference,
Partnering for Prevention: A TAASA and TCFV Summit.
We asked the Partnering for Prevention attendees what their ah-ha moment was during the conference.
To view full interviews, click here!
Partnering for Prevention isn't your typical conference. We pooled our expertise and resources to design a unique learning experience for prevention workers, community members, and program leadership based in current prevention practice and theory.
Prevention requires a community of practice: Participants will meet with others who share similar duties and interests to celebrate their successes, learn new skills, and discuss strategies for dealing with the real obstacles programs face when implementing prevention programming in their communities.
Prevention education takes time: The day-long workshop sessions are long enough for participants to delve into the training topics, dialogue with peers and presenters, and still have time to practice new skills.
Prevention work means getting at the root: The conference includes a Courageous Conversation, training to both encourage and challenge participants to look at how disparities and inequalities put our communities at risk for gender-based and other forms of violence.
Prevention is inspiring: Connection, rejuvenation, and wellness are themes woven throughout the conference with everything from a keynote presentation by Patricia Castillo of the P.E.A.C.E. Initiative to the use of art as a tool for education and transformation.Get ready to roll up your sleeves, join your peers to work arm-in-arm, and celebrate your statewide prevention efforts to end sexual and domestic violence.


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It's clear that Kenmore is riding on its old reputation of reliability while currently manufacturing junk. We have two recent model Kenmore dishwashers at two different houses. Both have developed leaks in the same part which controls the water supply to the unit. No, it's not the hose, it's the part on the dishwasher itself. I'll bet some Kenmore number cruncher decided it would be profitable to use cheaper parts in manufacture, but they are losing our business forever. Short term gain for the company, but a long term disaster. I'll bet they won't be able to figure out why people stop buying their products!
We have a Kenmore Elite refrigerator with French doors. The ice maker is horrible. Don't ever expect it to actually work if you buy one. We have a Kenmore clothes washer that leaks regularly near the top of the unit. Internet research makes me believe it's a design flaw. The design flaw in that is not fixable in any normal sense. We used to think of Kenmore as a reliable brand. WRONG!!!! What's the use? Just don't buy anything from Kenmore or its related names. (Whirlpool?) They deserve to go out of business.
I purchased this refrigerator in Sept. 2006 for $2500.00. I have been greatly disappointed in the quality - most of the inside, tracks for the drawers, etc. are made of flimsy plastic. We started having problems with the ice-maker within a couple of months. It has stopped working at least 4 times and then after a period of time will mysteriously start working again. It is not working at this time. Several of the drawer tracks have cracked and broken off, so I've had to take the drawers out.
About 1 1/2 years ago, the lights quit working because the factory installed bulb melted and started burning the light cover. I would never recommend this refrigerator to anyone and it definitely was not worth its price!!! I feel like I've been ripped off!!
This dishwasher seemed good at first... quiet, reliable. Then we started noticing it wasn't cleaning too well, even when we adjusted our loading technique. Then the touch buttons on the display began peeling, clearly a manufacturer's defect. Because of our extended service contract, the company replaced it, but we were told if it happens again, we must pay.
Next, the dishwasher stopped draining. A serviceman came and told us he pulled a cherry pit from the drain, and the problem was solved. We ran a load of dishes and it still did not drain. I phoned for service and the representative offered me an appointment a week away. I said that was not acceptable, given that we'd already had to wait for the first repair of this problem. She offered me an appointment a few days off... today.
When I called to check on the appointment, I was told it was NOT today, but next Saturday, and that's the best they can do. I sat on hold waiting to talk with a supervisor, and then was cut off. After having been a loyal customer for decades, I will never deal with Kenmore or Sears again.
ERIE, PENNSYLVANIA -- I purchased a top-of-the-line Kenmore Elite refrigerator about 6 years ago. It has a bottom drawer freezer and double top doors and stainless steel front. It cost about $1,700. The first one that was delivered had a very noisy compressor. We complained and they wanted to install a new compressor. We refused to accept a compressor replacement on a refrigerator that was only a few days old so they replaced the entire unit.
Shortly thereafter the ice maker broke twice. Then all the interior plastic began cracking and falling apart.
We kept renewing the service contract for about 4 years and finally dropped it. Recently, the compressor overload switch failed and we had it replaced on a 6 year old unit. Now, the compressor has failed and will need to be replaced at a cost of about $700.00. Between the four years of the service contract, and the recent costs of repairs we will have spent $1,160 to maintain and repair a $1,700 refrigerator.
It appears that Kenmore had designers working around the clock figuring out ways to cheapen the quality of this appliance while making it appear very attractive to unsuspecting customers. I will never buy another appliance from Sears. I would also like to mention that Consumers Reports rated this as a good refrigerator and I have come to distrust anything they say. I guess you should talk to an independent appliance repairperson and visit sites like this one before making a home appliance purchase.
I purchased this refrigerator in April 2004. The model # 72912200. The refrigerator looks like new, no dents or broken parts. The refrigerator has been working beautiful until this month we had two incidents with food spoiling/temperature failure. The Sears repairman said the compressor needed replacing to the tune of $673+. I had a $75.00 repair fee and $20.00 for a part he added to hopefully keep it working for a day or two if we're lucky. Apparently the compressor warranty is 5 yrs and we had the refrigerator 6 yrs. Why is it that appliances don't last 10 or 15 yrs anymore?
The one previous to this one we had 15+ yrs and it is still working for the family that I gave it to. I refused to pay for the $600+ repair and am now facing purchasing a new refrigerator. They will be dumping a refrigerator that looks new like the day I purchased it. The Sears repairman gave me a coupon for money off a new refrigerator and consumer service with Sears is giving me $100.00 off. Even with this little incentive I am just sick over this and now I have to deal with paying off another large appliance.
MOOSE JAW -- The appliances were new purchased by the builder in 2009. We moved into the home and started using them end of February 2010 -- almost 11 months after initial purchase date. The refrigerator had a faulty door that would not close properly. The service man had to dismantle the entire door complaining about poor quality control and getting worse every day. He did fix the problem under warranty.
Now in June the handle on the range fell off. It appears that the screws stripped the plastic handle insert and since the screws are about 1/4" to short anyway, the entire handle fell off. When I called the service dept. a very rude woman by the name of Vanessa flatly refused to connect my call to the contracting division who took care of my previous refrigerator complaint, and in fact hung up on me. After I check with some friends I find a number of them categorically say, "Never again Kenmore", the product is poorly manufactured, the warranty service time takes forever and the number of breakdowns are excessive.
My water heater's pilot keeps going out. I'm positive it's the thermocouple. I contacted Kenmore since it's only halfway through its six-year parts warranty. I was told that I had to have a service person come out to check it and determine if a new part was needed. If so, they'd order it, I'd have to wait for it to be shipped and have the service person return and install it. The part would be completely covered, this way though I'd be responsible for two separate service calls at $75 each. I could just pay $48 to buy the part and install it myself but it just seems wrong to me. I just thought I'd put it out there as a warning to others. Maybe I'm wrong and this is business as usual.
ADRIAN MI, MICHIGAN -- Purchased this Frankenstein monster of an dangerous appliance at Sears a few years back. The appliance operated perfectly for a few years then began going crazy. The compressor overload switch started clicking on and off and every time this poor compressor tried to restart the overload switch would shut it back down. The appliance would run for approximately 20 seconds and shut down. Replaced the start-up relay and fixed the problem for a short time.
Note: every time this energy sucking thing shut down, loud gurgling sounds could be heard coming from the top and bottom. This sounded a bit like a water faucet that needed to be turned completely off now. On the last week of its short life, started clicking on an off once again and humming quite loudly too, each time the compressor would restart. This annoying humming became louder and louder, and as the kitchen lights began to now flicker I had my hand on the hot power cord ready to pull it right out of the socket.
Next without any warning whatsoever this poorly designed piece of junk of a appliance literally exploded right next to me. I heard the distinct sound of some refrigerant (under extreme pressure) that was now spraying out all over the place. it was all quite deafening. Momentarily frightened by this monster of a fridge come to life, we grabbed our three kids and without hesitation ran for the back door which led into the back yard. That was the first time I had ever heard of an appliance blowing its top. Logically speaking, that is usually reserved for frustrated consumers like us.
MARYLAND -- Having hardwood floors in my home with only a few rugs, I purchased a basic Kenmore vacuum cleaner model # 216.37000 in October 08. I have found that this product does not function as one expects. The problem seems to be that the motor lacks sufficient power to propel the dirt all the way into the vacuum bag and instead it collects into a tight wad or bolus around the base after a very short use. Then the vacuum spits the dirt out into the room.
I have written a complaint to Sears head office and got a phone call from some secretary who kept telling me to take the vacuum to a Sears repair center although I insisted that the vacuum was not in need of a repair but that it was a manufacturing problem. It was a very unsatisfactory phone call with her finishing up saying that she would report the problem to the appropriate division. She gave me a phone number to call which was a waste of time.
The person who answered had no idea what to say and also ended up telling me to take the vacuum to a repair shop. The point is that this seems to be a model that should not be sold to an unsuspecting public. Customers who only want a basic product should not be fobbed off with this piece of rubbish.
MASSACHUSETTS -- When I redid the kitchen at our Cape Cod summer home last year (2008), we installed Sears Elite appliances because on the Cape, getting service for other upscale major brands can be difficult. No one at Sears explained to me that the icemaker/water filtration system in the refrigerator is really not appropriate for seasonal use, because it must be professionally drained each fall if the house will not be heated over the winter. It is impossible for a homeowner to drain the system.
And the Sears service representative informed me that they will NOT perform the service, either. My plumber refused to drain the system because it is difficult and time-consuming and sometimes the system still freezes and cracks the plastic components within the ice maker and filter system. I returned to the Cape this spring to a leaking water filter, no ice making, and a bill for $270 to repair the water filtration system, and it is not covered by the warranty.


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Tarzan the apeman.
reply to post by phantomjack
Or you could wait one more day (4-15-14) and you will have a blood moon. So I have read. As far as what will happen, who really knows. But something has to give. To many pawns being moved around on the chess board we call earth. Maybe there is to much info, more and more each day and we are on info overload.


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Discover and discuss the manliest content on the Web
Grilled Venison Tenderloin
Posted by ManTestedRecipes 2 years, 6 months ago from mantestedrecipes.com
ManTestedRecipes, bjbegoon, Havoc and 7 others like this
Grilled Venison Tenderloin -- This venison recipe has proven to please even people who claim they don't like venison. It's amazing what a little bacon and barbeque sauce can do!
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Gentleshy 2 years, 6 months ago
Wow, I am drooling over this recipe.


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Matthew 19:6New King James Version (NKJV)
6 So then, they are no longer two but one flesh. Therefore what God has joined together, let not man separate."
New King James Version (NKJV)
Scripture taken from the New King James Version®. Copyright © 1982 by Thomas Nelson. Used by permission. All rights reserved.
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Nearly naked burglar; bad break-in artist; plot to steal sheep.
Questionably brilliant innovations in portable toilets, beer finding technology, weapon storage, and wigs for newborns.
A literal cat burglar caught on tape; a fast food customer who asks for jail time; a naked guy that steals sausages; a woman tries to send a puppy in the mail.
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5 Deadpool Friends & Frenemies We Gotta See in the Sequel
Film, Comic Books
Showing results 81-120 of 548
"Shotgun Wedding" creative team William Harms & Ed Pun discuss the upcoming Top Cow weekly series about the wedding day of an assassin-for-hire.
CBR presents an exclusive preview of Matt Hawkins and Jung-Geun Yoon's "Tales of Honor" #1, based on David Weber's sci-fi novels.
Marc Silvestri brings a world of magicians, sorcerers, thieves and killers to life in "Rise of the Magi," his new ongoing series from Top Cow Productions.
Top Cow's Minotaur Press will release the latest chapter of writer/artist Larime Taylor's "A Voice in the Dark" #4, and CBR has an exclusive preview.
Ron talks to Laura Braga, his artistic collaborator on "Witchblade," about her career, breaking into the U.S. market and being a woman in a traditionally male field.
Matt Hawkins discusses adapting David Weber's "Honor Harrington" sci-fi novels to comics to prepare an expansion of her world to multiple mediums.
Take a look at the research involved when Matt Hawkins develops the world of Aphrodite IX in this preview of "The Hidden Files."
Read an exclusive extended preview of Larime Taylor's "A Voice in the Dark" #2, the finale of "Blood Makes Noise" from Top Cow's Minotaur Press imprint.
Ron Marz discusses his return to the world of "Witchblade" and his plans to take Sara Pezzini and company in an all-new direction.
CBR has an exclusive preview of "Witchblade" #170, which marks the return of Ron Marz to the Top Cow title he previously wrote for more than 70 issues.
Rob Levin discusses the inspiration and influences behind his and artist Jessada Sutthi's vampire versus Samurai tale "Bushido," which makes the jump from digital to print throughout October.
Courtesy of Top Cow, CBR presents an exclusive preview of "Think Tank" #10 by Matt Hawkins and Rahsan Ekedal. Dr. David Loren tries to stop a disaster without losing everyone he loves on 10/2!
Writer and artist Larime Taylor tells CBR about bringing his Kickstarter-funded comic "A Voice in the Dark," drawn entirely with his mouth and a Wacom tablet, to Top Cow's Minotaur Press imprint.
Courtesy of Top Cow, CBR presents an exclusive preview of "Witchblade" #169, writer Tim Seeley's final issue with art by Diego Bernard & Fred Benes. "Absolute Corruption" concludes 9/4!
Next week, the Image partner launches their second Talent Hunt, seeking aspiring writers and artists. CBR News talked to Matt Hawkins about the competition. Plus, an exclusive first look at this year's rules.
Courtesy of Top Cow, CBR presents an exclusive preview of "Aprhodite IX" #4 by Matt Hawkins & Stjepan Sejic. Aphrodite learns the truth about her origins and how she's been manipulated Aug. 21!
"Think Tank" writer & Top Cow CCO Matt Hawkins visited the CBR Speakeasy to discuss the companies Comic-Con announcements, his return to writing and upcoming projects like "Control."
Matt Hawkins spoke with CBR about Top Cow's Comic-Con announcements, touching on everything from "Teen Witchblade" and "Aphrodite IX" to a slate of new Minotaur Press series' and a "Darkness" film.
Madefire, the innovative digital comics studio, has announced a new partnership with BOOM! Studios, IDW, iTV & Top Cow, as titles from each publisher will be adapted to the company's trademark Motion Book format.
Image Comics has provided CBR with its October 2013 solicitations featuring images and info for "Pretty Deadly," "Velvet, "The Walking Dead," "Three," "Bushido," "Sex Criminals" and more!
Top Cow President and COO Matt Hawkins reveals exclusively to CBR that "Think Tank," his science-action series with Rahsan Ekedal, has become an ongoing and shares his future plans.
Courtesy of Top Cow Productions, CBR has an exclusive preview of "Witchblade" #167 by Tim Seeley and Diego Bernard. Former Witchblade bearer Katarina closes in on her prey in Chicago June 19.
Courtesy of Top Cow and Image Comics, CBR presents an exclusive preview of Matt Hawkins and Rahsan Ekedal's "Thin Tank" #8. Dr. David Loren is held accountable for his actions on June 26.
Top Cow founder and fan-favorite artist Marc Silvestri discusses the first arc of his successful Kickstarter-funded "Cyber Force" revival and what fans can expect from the initiative moving forward.
Longtime "Witchblade" scribe Ron Marz returns to the series in the wake of the Top Cow Universe-shaking "Darkness Falls" miniseries. CBR has the exclusive first word on what he has in store for Sara Pezzini.
Courtesy of Image Comics, CBR has exclusive previews of Brian Wood, Ming Doyle & Jordie Bellaire's "Mara" #4, plus "Cyber Force" #4 and "Miniature Jesus" #1. All three issues go on sale April 17.
Image Comics has released its complete July solicitations featuring images and solicitation info for "Satellite Sam," "Ghosted," "The Walking Dead," "Fatale" and many more!
Top Cow's long-running "Darkness" series comes to an end in July, and CBR has the exclusive first word on David Hine and Stjepan Sejic's follow-up miniseries, "Darkness Falls."
CBR has the exclusive word on the winners of Top Cow's 2012 Talent Hunt, as president Matt Hawkins shares a look at the winning entries and explains what went into selecting the best of the best.
"The Darkness" writer David Hine spoke with CBR News about laying the building blocks for Top Cow's "Progeny" crossover in the pages of his ongoing series with artist Jeremy Haun.
Image Comics has exclusively provided CBR with its complete June solicitations featuring images and solicitation info for "The Walking Dead," "Fatale," "Lazarus" and many more!
"Artifacts" writer and long time Top Cow Universe architect Ron Marz spoke to CBR News about the "Progeny" crossover event, Top Cow's first company-wide crossover since Rebirth.
"Hack/Slash" creator Tim Seeley opens up about his involvement in the Top Cow Universe-wide crossover "Progeny" and how it will affect his ongoing story in "Witchblade."
Courtesy of Top Cow Productions, CBR presents an exclusive preview of Stjepan Sejic & Ron Marz's oversized "Ravine" #1. The line between good and evil is blurred February 27.
Top Cow's Matt Hawkins discusses balancing his COO duties for the Image Comics partner studio with writing his own comic, "Think Tank," and bringing Pilot Season title "Theory of Everything" to the big screen.
Courtesy of Top Cow and Image Comics, CBR has an exclusive preview of "Witchblade" #163 by Tim Seeley, Diego Bernard & Fred Benes. Sara Pezzini takes the Witchblade on the other side of the law January 23.
Creator Stjepan Sejic takes readers on a guided tour of the characters filling "Ravine," his Top Cow fantasy graphic novel series co-written with Ron Marz.
Top Cow has provided CBR with an exclusive advance preview of "The Darkness" #110, the final chapter of David Hine and Jeremy Haun's "Breaking Dark" story arc. The issue hits January 30.
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PASSAGE - mirai by horoharoWatch
©2013-2016 horoharo
hes so cute!
wow, awesome lighting and colors! I love the affect of the eyes in this!
Love the really peaceful feeling here. C: Nice colors!
awesome! the feels..;w;
you're really really good, I would reach you in years T-T
Wow, you draw so soft and nice. I love it. :>
soooo beautiful !!!!! great job !
nice sign and headshot


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Almay One Coat Nourishing Mascara Triple Effect
223 reviews
58% would repurchase
Package Quality: 3.6
Price: $$
Package Quality: 3.6
Price: $$
Age: 30-35
Skin: Sensitive, Fair, Neutral
Hair: Red, Wavy, Medium
Eyes: Blue
I mostly like this mascara. Mostly. Not enough to buy this again, unfortunately, and here's why: it really does not thicken, I NEED my Shiseido mascara primer before I apply this or it has no oomph, but most of all it smudges and gives me panda eyes. I have long lashes and after wearing this for a few hours I notice that there is always black on my brow bone right under my eyebrows. I can wipe it off easily with my fingertip, but then my shadow goes too. Not cool. Also, it seems to dry out pretty quickly.
On the plus side it goes on smoothly and easily, doesn't flake or clump, stays put relatively well but comes off easily with mostly water and a bit of cleanser. Makes my lashes look lovely but I hate that it smudges. I'm going to end on a positive note: Almay doesn't test on animals and I love that. I've never seen an animal with makeup on, nor have I seen one carrying a makeup bag. Go Almay :)
Age: 36-43
Skin: Combination, Fair-Medium, Not Sure
Hair: Blond, Wavy, Fine
Eyes: Blue
Just bought this. Love this mascara, I've tried just about everything. YSL was my HG but they changed the formula recently. This Almay is goof for everyday use, didn't flake or smudge, and came off easily. Not sure how buildabe it is as I only used one coat, but foe day use one coat was perfect for me.
Age: 25-29
Skin: Dry, Fair-Medium, Neutral
Hair: Blond, Wavy, Medium
Eyes: Green
I'm wondering how long people are keeping the wand out of their tube and using this mascara. Because this is a gel based mascara and if you have a habit of pumping the wand or applying mascara for more than a minute, then it's going to dry out very quickly over a few weeks. That's if you're using it every day. I really cannot stand a mascara that is wet and too slick for application. It does nothing for anyone's lashes, and those tend to smudge beyond belief. I would rather have a mascara that builds volume and length really fast and then dries quickly so I can move on with my routine. Buying mascara once a month is not really a big deal if it does dry, and with a gel mascara the pigment of black is much more vibrant and an ultra black. It also has aloe (which won't effect the product) and vitamin E to condition lashes. I'm going to use it till the tube has been used up and then update.
Age: 19-24
Skin: Sensitive, Fair-Medium, Not Sure
Hair: Red, Other, Other
Eyes: Green
Decent mascara for a drugstore brand. I like the texture of the product and the volume it gave my lashes. It gave a great everyday look. The price is good and the product easy to remove. I found that the mascara seems to clump fairly fast after the tube is opened for the first time. Within 3 weeks it would get heavy and clump up on my lashes (I purchased 2 tubes from different places at different times and got the same result). I also developed an allergy to this product so I would not buy it again.
Age: 25-29
Skin: Combination, Fair, Warm
Hair: Blond, Other, Other
Eyes: Green
Like most Almay mascaras, I liked this one. It is fantastic for sensitive eyes.
The formula isn't as runny as other mascaras. I found it to work well adding volume. I bought blackest black & it lived up to my expectations. I wanted this mascara to be over the top dramatic (if you, like me love that look for day & night wear!) but this mascara isn't one of those.
It wears well & didn't smudge. I was very happy with this mascara.
Age: 19-24
Skin: Combination, Medium, Neutral
Hair: Brunette, Straight, Fine
Eyes: Brown
This is a really, really good mascara! I don't like shelling out the money for a high end mascara. I do think it makes a difference, but it's just not worth it for mascara's shelf life. This is actually my favorite drugstore mascara, I alternate this and Colossal. Colossal is easier to apply, but I think Almay's looks more natural and gives a prettier, fanned out effect if applied correctly. I actually find it lasts a month or two longer than my other mascaras. It lengthens and volumizes my lashes, but can get clumpy if I don't apply it carefully. I like this, and I'll keep using it unless something better from the drugstore comes along.
Age: 19-24
Skin: Dry, Fair-Medium, Warm
Hair: Black, Straight, Fine
Eyes: Brown
I don't think this product deserves the rating that it does. I think that it does what it promises (on my lashes): it lengthens, volumizes, and 'lifts' the lashes. The effect isn't as extreme as its competition in the mascara industry-- but it doesn't promise anything like "7x the volume!" as some other ones do. It does what it advertises. It doesn't exactly curl, but it doesn't weigh your lashes down either. That's the main reason I like it, I believe it's the only drugstore mascara that I can wear on my sensitive eyes. I love L'Oreal and Maybelline but they sting and weigh on my eyes too much. I got this in blackest black, and it's a very true black. I was happy that it didn't smudge or flake on me, even through a full day, was not clumpy, and because it doesn't promise to be waterproof/resistant, it was very easy to take off with a remover. I found the brush strange (I didn't expect it; I hadn't read any reviews before buying it) but it worked. I'm not sure which side is supposed to do what, but the long side seemed to deposit more product while the short side brushed and separated. This retails for about 7CAD. **UPDATE** love revoked! terrible mascara... I may have been wearing rose-coloured glasses.
Age: 25-29
Skin: Oily, Olive, Warm
Hair: Brown, Other, Other
Eyes: Brown
Not very impressed with this one. I think I prefer a more traditional brush to get into and separate my lashes, which are fairly long but need a bit of definition. This brush is an odd "half" brush with bristles on one side. I always seem to apply unevenly on each eye due to how I hold it. Not a fan of the formula either, I don't find it particularly remarkable in lash lengthening. It does not flake on me, but I came in from a few drops of rain and had it pooling under my eyes (I know it's not waterproof, but a little bit of water tolerance would be nice). Would not bother again.
Age: 19-24
Skin: Combination, Fair, Not Sure
Hair: Brown, Other, Other
Eyes: Green
I am disappointed by this product. The effect is ok, but not fantastic. This mascara flakes a lot!!! The brush makes the application complicated since it does not separate well. There are better drugstore mascaras like those from Maybelline.
Age: 25-29
Skin: Normal, Medium, Not Sure
Hair: Black, Other, Other
Eyes: Brown
I have tried this two times, and both tubes went in the trash two weeks after starting them -- the two week mascara grace period! I have short, fine eyelashes and this formula did nothing for them. Would much rather go back to Covergirl Lash Blast, etc. However, it does look from the reviews that several people like this b/c it is vegan, more hypoallergenic, etc. If you have those needs, definitely try it out. But I feel that the formula/brush is mediocre at best.
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text:
FDA Panel Flubbed in Arena's Lorcaserin Disapproval 58 comments
Last week's FDA panel that voted 9-to-5 against approving Arena Pharmaceuticals' (NASDAQ:ARNA) obesity drug Lorqess (lorcaserin) apparently blundered in its assessment that the company's rat breast tumor findings merit concern, according to the FDA's own published standards.
Bloomberg reported that "a panel of outside advisers to the FDA voted against recommending the drug for approval, citing concerns about tumors seen in rats in early-stage testing of the drug. … Of particular concern was the increase of mammary tumors in rats treated with lorcaserin, the committee said."
But here's how the FDA panel was earlier briefed:
Lorcaserin was investigated in a standard battery of genotoxicity, reproductive toxicity, general toxicity, and carcinogenicity studies. Lorcaserin showed no reproductive toxicity or genotoxicity. General toxicity studies were conducted in mice, rats, and monkeys at doses that produced very high exposure multiples relative to the human maximum recommended dose (NASDAQ:MRD). In repeated dose Good Laboratory Practice (NYSE:GLP) toxicity studies, lorcaserin was generally well tolerated at doses below the maximum tolerated dose (NYSE:MTD) in all three species and there appeared to be no adverse findings of direct relevance to humans at therapeutic doses [emphasis added].
Two-year carcinogenicity studies were conducted in mice and rats. There was no evidence of carcinogenicity in mice. In rats, and almost exclusively male rats, tumors were found in multiple organs primarily at the highest dose, which provided an exposure that was 56-fold greater than human and was clearly above the MTD [emphasis added].
So lorcaserin was found not to be genotoxic, meaning it does not harm a cell's genetic material, especially DNA. Rather, lorcaserin's mechanism for promoting breast tumors at only high, toxic doses may be hormonal, in a way that apparently does not exist in humans. According to the FDA brief, "The mammary tumors are attributable to increased prolactin, a mechanism peculiar to the rat."
Prolactin is the pituitary hormone that causes milk production in the breast. Although a role for prolactin in the promotion of breast cancer has been proposed, recent research indicates that prolactin protects against aggressive human breast cancer, at least by blocking an oncogene called BCL6.
Besides, lorcaserin does not raise prolactin levels in humans.
[T]he relevance of these tumors to humans is questionable because: 1) lorcaserin is not genotoxic; 2) substantial margins and/or rodent specific mechanisms were identified for each of the tumors; 3) the tumors were found primarily in one gender of one species at a toxic dose; and 4) no preneoplastic or neoplastic lesions were found in any other toxicity studies in the rat, mouse or monkey.
Rat tumors, benign and malignant
Male rats had a significant benign breast tumor (fibroadenoma) incidence only if they received 56 times the lorcaserin exposure humans would get at the proven-effective dose of 20 mg per day.
Male rats had no significant increase in breast cancer (adenocarcinoma) at any dose of lorcaserin.
Female control rats, who received no lorcaserin, showed high rates of spontaneous benign and malignant breast tumors at baseline. Forty-three percent of female rats that never touched lorcaserin developed cancer! That's just how these animals' bodies operate.
Female rats developed significantly more benign breast tumors (fibroadenomas) at all doses of lorcaserin, but this has no known implication for human cancers.
Female rats showed a significant increase in breast cancer (adenocarcinoma) only if they received 84 times the lorcaserin exposure humans would get at the standard dose of 20 mg per day.
Excerpts of the FDA briefing tables:
Male Rats
Mammary Gland Neoplasms in Male Rats and
Lorcaserin Exposure Margins Above Human Exposure
Dose (mg/kg)
Lorcaserin margin over human
Number of male rats
Benign fibroadenoma*
* Trend is significant (p = 0.0001). Significantly different from control at 100 mg/kg (p = 0.002).*******
Female Rats
Mammary Gland Neoplasms in Female Rats and
Lorcaserin Exposure Margins Above Human Exposure
Dose (mg/kg)
Lorcaserin margin over human
Number of female rats
28 (43%)
34 (52%)
35 (54%)
60* (80%)
Benign fibroadenomaa
20 (31%)
47* (72%)
54* (83%)
45* (60%)
a Trend is significant (p < 0.0001).
* Significantly different from control (p < 0.0001)*******
Should the FDA worry if megadoses of lorcaserin cause tumors in rats?
Is a significant increase in female rat breast cancer, seen at no less than 84 times the human exposure level of lorcaserin, even a problem for humans?
Not according to the FDA's prior reviews of scientific studies and its published guidance to drugmakers.
The FDA's September 2008 Guidance for Industry: S1C(R2) Dose Selection for Carcinogenicity Studies says:
It has been agreed that if a drug is only positive [for a cancer association] in rodents at doses above those producing a 25-fold exposure over exposure in humans, such a finding would not be considered likely to reflect a relevant risk to humans.
Arena found a significant benign tumor rate in male rats exposed to no less than 56-fold amounts of lorcaserin compared to what humans would receive, and a significantly increased cancer rate in female rats exposed to no less than 84-fold amounts. These dosages are well above the FDA threshold of "25-fold exposure over exposure in humans." Therefore, "such a finding would not be considered likely to reflect a relevant risk to humans," according to the FDA's prior, considered scientific findings and advice to pharmaceutical manufacturers.
No wonder Arena CEO Jack Lief said in a conference call with analysts last Friday that it was a "shame" there were no experts in carcinogenesis or toxicology on the panel.
"My view is they were having difficulty understanding the presentation," he said.
How well did FDA no-vote panelists grasp Arena's rat tumor findings?
BioWorld's Donna Young reported:
[FDA panelist] Edward Gregg, chief of epidemiology and statistics in the Centers for Disease Control and Prevention's Division of Diabetes Translation, said he was "spooked" by the rat study tumor results.
Many on the panel of metabolic and endocrinology experts, however, acknowledged that their particular expertise was not in cancer, and therefore, had difficulty interpreting the rat study results. ...
Given the potential for lorcaserin to be used by hundreds of thousands of women once it enters the U.S. market, "there is just too much uncertainty" without more studies to answer the tumor question, said [FDA] panelist Jacqueline Gardner, a professor of pharmacy at the University of Washington.
What is the uncertainty to which pharmacist Gardner refers? Could it be based on some panelists' difficulty in interpreting Arena's data, or in determining its applicability to humans in accordance with cancer biology principles?
Panelist Michael Proschan, a mathematical statistician at the National Institute of Allergy and Infectious Diseases, seemed honest about his perception of the rat tumor data. "I feel totally lost," he said. "I have no idea how to translate from animals to people."
Lorcaserin may play an important role not just in weight loss, but also in treating complications of obesity. According to the FDA brief, "Lorcaserin 10 mg BID caused significant improvements in blood pressure, lipid profiles, and insulin resistance in parallel with weight loss."
In a July 2010 New England Journal of Medicine editorial, obesity expert Arne Astrup, MD, wrote, "The justification for using lorcaserin to manage obesity is not greater efficacy than currently available drugs [orlistat (Xenical by Roche (OTCQX:RHHBY) and Alli by GlaxoSmithKline (NYSE:GSK)), and sibutramine (Meridia by Abbott Laboratories (NYSE:ABT))], but rather an apparently much better safety and adverse-event profile and very clear-cut beneficial effects on risk factors for type 2 diabetes and cardiovascular disease."
The FDA owes the public a commitment to competent scientific evaluation in its drug-approval decisions. It should act consistently with its prior scientific findings and industry guidance, promptly overrule the lorcaserin panel's mistaken vote, and set the record straight on lorcaserin's cancer safety findings.
Disclosure: Long ARNABack To James Hill, MD's Instablog HomePage »
Instablogs are blogs which are instantly set up and networked within the Seeking Alpha community. Instablog posts are not selected, edited or screened by Seeking Alpha editors, in contrast to contributors' articles.Comments (58)Track new comments
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hey, appreciate the article as an Arena Long. I happen to agree with you. But what you're linking to is Arena pharmaceutical's Briefing Document, not the more negatively toned FDA Briefing Document on the subject of rat neoplasms. the FDA Briefing Document does not agree on a prolactin mediated mechanism, which would have saved Arena because like you said there is no prolactin increase in humans.
Every single person who is holding ARNA long absolutely needs to write thier congressperson a snail mail letter and send copies to the FDA department heads and also to the first lady. Mrs. Obama is a vocal advocate about the dangers that become multiplied in obese people. She knows viable treatments are needed and may even be following the Arena stink going on. If you are in need of some real payback on your investment like I am, you should write congressperson and senators minimum. There needs to be enough public outcry on this in order to get any real resolution in this disgrace of a highjacking by the FDA for some unknown reason. Most likely the shorts heavy hands are involved at a personal level. People about to lose billions on a bad short investment will do anything to change that including threats of violence on neutral or impartial parties connected to the final outcome in the decision making process. If you were in the position of controlling billions of investors dollars and therefore had the resources to have strong arms influence the positions of those in the decision making process, and those billions were at great risk of being lost also putting your livelihood and/or life at risk, wouldn't you also use whatever means you had available to you to tilt the outcome to your favor? I think the answer to that one is easy. Of course you would. Now that the shorts have had or will have time enough to cover their shorts up until Oct. 21st, hopefully if enough people write influential people who can lean on the FDA to make the correct decision, we will get that approval we need and Arena absolutely deserves. Arena spent hundreds of millions of dollars testing their drug and it passed everything and should have had no problem in that panel voting at all. It is obvious there is something wrong amiss here. I don't know what it is. I am only speculating. But what I am speculating sure seems like I have the right idea. Maybe not I don't know. Just write those people and cite the reasons the author of this article gives. Not mine. I have nothing to back my ideas up. This author does.
Additional mention should be made that FDA deputy Coleman (a non-voting FDA presence) spooked the voting members with an inflammatory prejudicial warning about any approval voters having their names "forever linked to the recall" of Locaserin were it to receive
The FDA is not going around looking for articles like this in order to come to a decision. The only way they will get this articles information into their unfocused neural pathways is for all of us to copy it to a document template and then make some changes so they don't get a bunch of the exact same letter and just toss those out before reading them. Also the real movers in this equation are going to the people who can bring the most attention to this for us so the FDA will have no choice but to fairly give its ruling on October 22. Those people who can make the most noise are your congressman and senators and the first lady. These four people(your specific three in congress plus the first lady) should get bombarded with mail from the postman. Hand delivered with a return receipt request. This should be your top priority. If you lost more than five thousand then surely you can justify the small cost of making certain sure your letter is delivered to them and signed for. This will almost guarantee the intended recipient will open it and read it. This is really really important. We all know lorcaserine should have got the green light or the recommend vote to approve. The data is clear and easily speaks for itself. Try to save your investment a lot quicker and much easier than just waiting it out and hoping for the best. That won't work, the guy who is in charge is doing this misinformation campaign for a reason. WE have to put the pressure on that will force him to do the correct thing. To do his job the way it is intended to be done. Fairly and with an impartial non bias criteria. So write them and send them. Ten bucks is a lot less risk than you originally put up and the reward could be oh so sweet.
The FDA appears to be arbitrarily "raising the bar" on obesity drugs when obesity is becoming a national epidemic. I think this is a big mistake by the FDA. Here's why:
Please see this article about the Adverse Childhood Events (ACE) study : <www.psychotherapynetwo...;. It argues against there ever being a "homerun" drug for obesity and against too rapid weight loss without understanding and working with the powerful psychological factors underlying many obese patients. For me, it also argues for a safe and gradual approach to weight loss using many tools. I think Arena's drug Lorcaserin should and can be one of them.
Also check out: www.newsweek.com/2010/.... which explains how rational arguments can fall on deaf ears since from an evolutionary standpoint it is better to be right than rational! I think many on the AC panel were too afraid of being wrong.
The FDA appears to be arbitrarily "raising the bar" on obesity drugs when obesity is becoming a national epidemic. I think this is wrong, here's why: Please see this article about the Adverse Childhood Events (ACE) study : <www.psychotherapynetwo... >
It argues against there ever being a "home run" drug for obesity and against too rapid weight loss without understanding and working with the powerful psychological factors underlying many obese patients. For me, it also argues for a safe and gradual approach to weigh loss using many tools. I think Arena's drug Lorcaserin should and can be one of them. Also see: Please see: www.newsweek.com/2010/.... which explains how rational arguments can fall on deaf ears since from an evolutionary standpoint it is better to be right than rational! I think the AC committee and Colman did not want to be "wrong" and made the safe but irrational choice.
Lorqess hits the satiety receptor in the brain and makes the patient feel full. The current most popular obesity drug, phentermine, stimulates metabolism to burn off calories, but can only be used for 12 weeks at a time. Patients lose weight on phentermine and then gain it back during the period they are off the drug. Lorqess would be very useful to help keep the weight off during this period - note that this is NOT combination therapy with phentermine.
Their seems to be some question on other boards if the "Briefing Document" you quoted is one submitted by ARNA and not the one written by the FDA. Could you please comment on the differences.
James - As you know, the FDA added the benign and malignant tumor counts together, and then focused on that number for statistical significance. Pure FUD, but they got away with it at the panel.
@Dr. Ritacca:
The link broke to the rat fibroadenoma article finding no progression to cancer. Here is an updated link:
Thanks to all who pointed out I cited the ARNA brief to the FDA, not the later FDA staff brief. I was unaware of the latter when I wrote the article, but I'll review it and probably either write an updated article or further provide comments here.
fibroadenomas do not degenerate into carcinoma. Are you telling all your patients to get their fibroadenomas excised because they can degenerate? If you believe in this malignant degeneration, you must be excising all of these.
They rarely progress to adenocarcinoma.The histologic features of the fibroadenoma influence the risk of breast cancer. The risk of subsequent breast cancer is slightly elevated only if the fibroadenoma is complex, if there is adjacent proliferative disease or if there is a family history of breast cancer. For the majority of women with simple fibroadenomas, there is no increased risk of developing breast cancer. In fact, without these conditions f a biopsy proven fibroadenoma is asymptomatic, then it can be left in place.
A prospective study of benign breast disease and the risk of breast cancer.London SJ; Connolly JL; Schnitt SJ; Colditz GA JAMA 1992 Feb 19;267(7):941-4.
they do NOT progress. there is absolutely no established malignant potential of a fibroadenoma. so-called complex fibroadenomas are thought to POSSIBLY represent a marker for carcinoma, but that is far from certain. Cases of malignancy are not thought to arise from the fibroadenoma itself.
What is confounding as regards this whole AdCom procedure is that Arena mngt. had access to the FDA briefing docs ahead of time...they should have been prepared to educate the panelists and refute any inappropriate or inaccurate inferences on the part of the FDA. Everything was riding on their preparation & presentation...they had sufficient warning, yet they failed to adequately assess the serious nature of their predicament and vigorously refute the FDA's pseudo-science. It is possible that Colman so poisoned the atmosphere with bias and intimidation that it wouldn't have made sufficient difference...but we will never know because they weren't prepared. Arena was ambushed, but they had time to recognize and prepare an aggressive defense...this is why strong, 'think on your feet' mngt. is so important.
I think the statement that lorcaserin is only increasing cancer in these mice at the highest dose is based in an incorrect application of statistics.
John - Thank you for confirming that there was no statistically significant increase in malignant tumors except at the highest dosage levels.
I'm confused.Are the tumors in the rats significantly/ statistically related to all doses.It appears Mr.Tucker thinks so but everyone else(except FDA) disagree.Is there a statistician in the house.
My consensus from the Hill's article that they increased but not statistically at the 95% confidence level.Comments please.
Go to the FDA briefing document at www.fda.gov/downloads/......
NS= not statistically significant SS=statistically significant
Notice that the brain tumors were only SS at the highest level - that was 56x or 84x the human dose.
The FDA had to combine the benign and malignant tumor data to get any SS on the mammary tumors in male rats. The other cancers were only SS at the highest level.
For female rats, malignant mammary tumors were only SS at the highest level. FDA again had to combine the benign and mammary data to force SS at lower levels.
Their argument for combining was that the female rats eventually died of the fibroadenomas due to organ pressure. Apparently, they think women might get a fibroadenoma and not bother to have it treated as it grows to 50 or 100 pounds.
John Tucker's argument is that the higher the dose, the more tumors appeared, so let's lower the SS boundary to ??% and make them all SS.
As you know, rats get cancer the way we get colds. If you inject water subcute in a rat, it will get tumors. The more water you inject, the more tumors it will get.
I live on a farm. I know BS when I smell it.
From my review of the literature and in conversations with oncologists,adenoms and adenocarcinoma are not related in the breast-maybe in other cancers such as gut or orbit.But in the breast one is benign and the other malignant, and the breast adenoma will not become a serious adenocarcinoma over time!
From what my oncology friends tell me,they should not be grouped together when talking about breast cancer.
Mike, in our past interactions you have always been a very gracious person, so I'm surprised that you would jump in and attempt to define my position without giving me the chance to do so myself.
John, the company had to show at the 95% confidence level that Lorqess does not cause a statistically significant increase in malignant tumors. They showed that at all but the highest levels of the drug. The FDA does not have to prove the drug is carcinogenic, they require the company to prove it is not carcinogenic. At the 95% confidence level, ARNA did that.
This mechanism may not have an explanation or a correlation in humans if it hormonally regulated in the rats.i have a feeling that proving the pathway in the rats is going to be a lot more difficult than it looks.The positives are,it's not gentoxic or carcinogenic and doesn't effect hormones in humans.I would be hard pressed to believe this drug at These levels is stimulating brest tissue directly and causing carcinogenicity especially when they already proved the drug wasn't carcinogenic
Hi Dr. Ritacca,
With regard to the statistical argument, perhaps it would be helpful if I expressed my idea another way:
Dr. Ritacca is correct - they should never have combined benign tumors with malignant tumors to reach SS.
A prospective study of benign breast disease and the risk of breast cancer.London SJ; Connolly JL; Schnitt SJ; Colditz GA JAMA 1992 Feb 19;267(7):941-4.
(Ron Greenberg, MD,1 Yehuda Skornick, MD,1 and Ofer Kaplan, MD: Management of Breast Fibroadenomas, J Gen Intern Med. 1998 September; 13(9): 640–645)
In the nonclinical 2-year carcinogenicity study, sexually-mature SD female rats were given an oral dose of Lorcaserin that was approximately 82-fold greater than the proposed therapeutic dose for human use, per mean blood plasma mean AUC levels. The female rats were therefore dosed with Lorcaserin at significantly above the 25-fold ICH limit dose referred to above, taking into account the mean plasma AUC concentrations.
Second is the interpretation of the interpretation of the carcinogenic data in the FDA briefing. . In the section entitled "Safety of Lorcaserin" (6th paragraph; Malignancies in Rats), the FDA states: "An excess number of malignant tumors developed in female rats with Lorcaserin at doses within 7-fold of the proposed clinical dose of 10mg BID." This conclusion is incorrect. The statement implies that statistically, the 10mg/kg/day female SD rat dose (7x dose group) was significantly different from controls. However, the only malignant tumor detected in the females given Lorcaserin at 10mg/kg/day was mammary adenocarcinoma, but its incidence was not statistically different from that in theof control rats (Table 4, NS). Based on findings in Table 4, the breast tumor incidence is only statistically different from untreated control rats if the different tumors are combined, but this is not a valid procedure because one of the tumor types is malignant (adenocarcinoma), the other benign (fibroadenoma). While it is true that benign and malignant tumors are commonly combined, this should only be done if the following criterion is fulfilled: "Benign and malignant neoplasms of a particular histogenesis are often grouped because the one is seen as a progression from the other" (Preclinical Development Handbook Toxicology 2008 John Wiley & Sons New Jersey Carcinogenicity Studies 424- 455).
Just a few more comments on this, I should really turn off my web browser and get some work done.
Whether the grafts look good or bad is not a vaid arguument.The only
point I would be concerned about is the SS with 95% confidence.The other point is if this is prolatiin effect or a mechanism associated in rat brains,how do we control for prolactin.I'm afraid Arena has to come up with a better explanation why this is not relevant in humans or do a larger rat study
Dr. Ritacca, with respect to males the FDA's most important argument seems to be that the increase in prolactin is not sustained on chronic dosing. In females, Arena was apparently unable to show a statistically significant increase in prolactin due to large inter-rat and time-of-day variability in prolactin levels, and so went to studies involving castrated female rats treated with exogenous hormones. The FDA did not think this was a realistic model of the conditions in which the tumors were observed in the 2 year study, and was not impressed by the amount of increase. Perhaps more importantly, they noted that dexfenfluramine, which does substantially increase prolactin levels in intact and castrated female rats, does not induce mammary tumors. This is apparently historical tumor data from the dexfenfluramine NDA, I did not see it in the briefing document.
How do you think they'll explain the mechanism for the rat problen.What did the FDA toxicologist mean when he said,"there still is a path to approval"?
When I read the literature on prolactin causing mammary tumors,I get conflicting stories.The FDA doesn't think prolactin caused this problem because of(1) lack of a prolonged elevation of prolactin from lorqcaserin,(2)haloper... caused elevation of prolactin but not tumors and(3) the in some of the statements made by Arena prolactin, dopamine and serotonin in the rats have shown to cause cancer.What is it?You can't have it both ways.Either prolactin does or does not cause mammary cancer.Am I missing a piece of the puzzle?
My understanding is that certain compounds acting on dopamine pathways (antipsychotics in particular) have been approved in spite of causing mammary tumors in rats, based on the belief that the carcinogenesis is due to stimulating prolactin levels, and that humans are much less sensitive to the carcinogenic effects of high prolactin levels. I haven't dug into it much deeper than that.
Thank you for your efforts, Doctor.
Another know-it-all academic who refuses to see the man (or should I say woman, hint-hint) behind the FDA curtain. I suspect October 23 will be even more of a let down to you then November 3, James. I just hope you longs can pump this loser stock back up to 3-4 so I can short it (again.) Keep up the good work. PS, go over the the Yahoo ARNA board if you want to jump on the "write your congressman" bandwagon.
John Tucker ..from his profile " currently works as a consultant in biomedical technology assessment."... Translated that means that John works for hedge funds and is paid to offer an opinion... I will leave it at that... The dosage that we're talking about is not relevant per the FDA's own documents.... FDA just approved Victoza a drug that was shown to cause cancer in rats (both male and female) at clinicaly relevant dosage... John, I assume you have not comented on that anywhere... Furthermore, even the FDA subsequently admited that the panel wasn't constructed to deal with the rat issue... Let's face it, the only reason this came out is Colman, and we all know by now why that was ..
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Home > News > Cricket News
It was an amazing performance: Cook
Posted on Aug 18 2014 | IANS
London, Aug 17 : England skipper Alastair Cook, who led his side to make a remarkable turnaround to win the five-match Test series against India 3-1 despite being 0-1 down in the beginning, called it "an amazing performance".
After drawing the first Test, England lost the second at Lord's and questions were raised at Cook's captaincy. However, he maintained his composure to turn the tables and aid the hosts win the next three matches.
"It was an amazing performance to win like we've won after what happened at Lord's. The players, the staff can take an enormous amount of credit. All summer, before we won at Southampton, we played good cricket in patches and then let it go after an hour or so. To maintain pressure like we did in the last few games was impressive," he said.
Though 0-1 down in the series, England did not look back and went from strength to strength to clinch the next three matches by 266 runs, an innings and 54 runs and an innings and 244 runs respectively.
"It's good to have the support of the guys throughout the tough times and then enjoy the good times. When you score runs, with our bowling attack in these conditions, it's hard for the opposition," added the left handed bat.
"We have to enjoy tonight, look at how we have got things to click and then take it on. In sport, you have tough times, it's the character you need to show to bounce back. The support has been fantastic, from the families as well, means we can go out and play some good cricket."


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Chris Jericho returns
When it comes to surprising the audience, Chris Jericho is one of the performers who takes a lot of pride in that. Initially, he was scheduled to make his return to WWE next weekend at live events. However, the former world heavyweight champion decided to come back this weekend instead. Fans in Montgomery, Alabama were treated to his appearance tonight. Jericho worked a singles match against Luke Harper and got the win.
January 10, 2015
Jack Swagger pushed down
When Jack Swagger was given a slight push by WWE earlier in the month, there were some fans who were under the impression that he was going to be moving back up the ladder again. However, as reports had stated, the former world heavyweight champion was simply used to elevate Rusev in a stall feud. Swagger is moving back down the ladder now, as evident by the fact that he put over Luke Harper in a match on Monday Night Raw.
December 30, 2014