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Book your room at Comfort Inn
Standard Room, 2 Queen Beds, Non SmokingMax Occupancy: 4 guests (up to 3 children, 2 infants)
Standard Room, 1 King Bed, Non SmokingMax Occupancy: 2 guests (up to 1 child, 1 infant)
Standard Room, 1 King Bed, Non SmokingMax Occupancy: 2 guests (up to 1 child, 1 infant)
Get an overview of this hotelMotel in Joliet with free breakfast and indoor pool
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Situated in Joliet, this motel is 1 mi (1.7 km) from Joliet Junior College and within 9 mi (15 km) of Rialto Square Theater and Silver Cross Field. University of St. Francis and Joliet Area Historical Museum are also within 9 mi (15 km).
Property Features
Along with an indoor pool, this motel has a fitness center and conference rooms. Free buffet breakfast and free self parking are also provided. Additionally, dry cleaning, laundry facilities, and a 24-hour front desk are onsite.
Room Amenities
Rooms feature free WiFi, coffee makers, and cable TV. Free local calls, hair dryers, and phones are among the other amenities that guests will find.Information missing or incorrect? Tell us!Opens in a new window
Hotel Amenities
Hotel Amenities
Comfort Inn features an indoor pool and a fitness center. A complimentary breakfast is offered. This Joliet motel also offers tour/ticket assistance, laundry facilities, and dry cleaning/laundry services. Complimentary self parking is available on site.
- 24-hour front desk
- Number of floors - 3
- Free breakfast
- Conference space
- Fitness facilities
- Dry cleaning/laundry service
- Elevator/lift
- Tours/ticket assistance
- Laundry facilities
- Free self parking
- Indoor pool
Family Friendly Amenities
- Indoor pool
- Free Wi-Fi
- Laundry facilities
Available in all rooms: Free WiFi
Free self parking
Room Amenities
- Air conditioning
- Phone
- Desk
- Cable TV service
- Free local calls
- Coffee/tea maker
- Free WiFi
- Hair dryer
- Iron/ironing board
Where to Eat
Guests are offered a complimentary hot/cold buffet breakfast.
Nearby Things to Do
Recreational amenities at the motel include an indoor pool and a fitness center.
- Golfing nearby
Hotel Policies
Check-out time is noon
Payment types
Pets allowed
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
Service animals exempt from fees/restrictions
Optional extras
- Pet fee: USD 20.00 per pet, per night
Hotel Name
- Comfort Inn Joliet
- Comfort Inn Motel Joliet


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subset: commoncrawl


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Dr. Tanyi is a Penn Medicine employed physician.
A facility of the Hospital of the University of Pennsylvania
Medical School: University Medical School of Debrecen
Residency: Semmelweis University, Medical School
Residency: Baylor College of Medicine - Ben Taub General Hospital
Fellowship: Hospital of the University of Pennsylvania
Tanyi JL: Endometrium hyperplasia and carcinoma Obstetrics and Gynecology Board Review: Pearls of Wisdom, Fourth Edition 44:441-49 : 2014.
Tanyi JL: Cervical lesions and cancer Obstetrics and Gynecology Board Review: Pearls of Wisdom, Fourth Edition 43:431-39 : 2014.
Kandalaft LE, Powell Jr DJ, Chiang CL, Tanyi J, Kim S, Bosch M, Montone K, Mick R, Levine BL, Torigian DA, June CH, Coukos G: Autologous lysate-pulsed dendritic cell vaccination followed by adoptive transfer of vaccine-primed ex vivo co-stimulated T cells in recurrent ovarian cancer. Oncoimmunology 2(1):e22664 : 2013.
Zsiros E, Frank R, Hagemann IS, Lee H, Tanyi JL, Feldman M, Coukos G: Mapping the chemokine microenviroment in ovarian cancer. Poster on the 44th Annual Meeting of SGO, Los Angeles, CA, March : 2013.
Zsiros E, Duttagupta P, Garrabant T, Levine B, Tanyi JL, Kandalaft LE, Coukos G: Chemokine receptors enhance T-cell vaccine homing to ovarian cancer. Poster on the 44th Annual Meeting of SGO, Los Angeles, CA, March : 2013.
Beer LA, Wang H, Tang HY, Cao Z, Chang-Wong T, Tanyi JL, Zhang R, Liu Q, Speicher DW: Identification of multiple novel protein biomarkers shed by human serous ovarian tumors into the blood of immunocompromised mice and verified in patient sera. PLoS One 8(3):e60129 : 2013.
Yang X, Zhong X, Tanyi JL, Shen J, Xu C, Gao P, Zheng TM, Demichele AM, Zhang L: mir-30d Regulates multiple genes in the autophagy pathway and impairs autophagy process in human cancer cells. Biochem Biophys Res Commun 431(3):617-22 : 2013.
Hu X, Guo J, Zheng L, Li C, Zheng TM, Tanyi JL, Liang S, Benedetto C, Mitidieri M, Katsaros D, Zhao X, Zhang Y, Huang Q, Zhang L: The heterochronic microRNA let-7 inhibits cell motility by regulating the genes in the actin cytoskeleton pathway in breast cancer. Mol Cancer Res 11(3):240-50 : 2013.
Chiang CL, Kandalaft L, Tanyi JL, Hagemann AR, Motz GT, Svoronos N, Montone K, Mantia-Smaldone GM, Smith L, Nisenbaum HL, Levine BL, Kalos M, Czerniecki BJ, Torigian DA, Powell DJ Jr, Mick R, Coukos G: A dendritic cell vaccine pulsed with autologous hypochlorous acid-oxidized ovarian cancer lysate primes effective broad antitumor immunity: from bench to bedside. Clin Cancer Res 19(17):4801-15 : 2013.
Yang JY, Yoshihara K, Tanaka K, Hatae M, Masuzaki H, Itamochi H; Cancer Genome Atlas (TCGA) Research Network, Takano M, Ushijima K, Tanyi JL, Coukos G, Lu Y, Mills GB, Verhaak RG: Predicting time to ovarian carcinoma recurrence using protein markers. J Clin Invest 123(9):3740-50 : 2013.
Proton therapy is a non–invasive, incredibly precise cancer treatment that uses a beam of protons moving at very high speeds to destroy cancer cells.
Our experienced cancer nurses and referral staff are here to help. Call 1-800-789-PENN or complete an online request.
Learn more about the benefits of translational research at Penn Medicine.


text: Hi, I was hoping someone could clarify Ampere's Law for me. The equation says that the only current that contributes to the magnetic field is current enclosed by the loop you select. But say you had a straight wire running through a solenoid, each having a current. If you selected a circular loop with a radius that is less than the solenoid radius but encloses the wire, wouldn't the magnetic field on that circle be changed by the solenoid's magnetic field created by its current, despite the solenoid's current not being enclosed? I am sort of confused and my prof. just kind of brushed me off saying: it cancels out. Could someone clarify either his statement or my misunderstanding? Any help is appreciated. Actually now that I am typing it this is something I didn't quite understand regarding Gauss's Law either, which also has only "enclosed" charge contributing to the Electric field even when there are outside charges. I feel like both explanations should be similar...?


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Brie, Bacon and Cranberry Pastries
Total Time
Prep 15 mins
Cook 15 mins
For the holidays - these can be made up ahead of time and frozen.
Ingredients Nutrition
- 1 lb phyllo dough
- 3⁄4-1 cup butter, melted
- 1 (16 ounce) can whole berry cranberry sauce
- 10 ounces brie cheese, cut into 1/2 inch cubes
- 10 slices bacon, fried crisp,crumbled
- Preheat oven to 350F.
- Cut phyllo dough in half lengthwise.
- Keep half covered with plastic wrap and damp kitchen towel while working.
- Place two sheets of phyllo dough on work surface and brush with butter.
- Fold in half lengthwise and brush with more butter.
- Place 1 1/2 tsps cranberry sauce, 8 cubes Brie and nearly a tsp of crumbled bacon at the bottom of strip.
- Diagonally fold corner over filling, forming a triangle.
- Continue folding triangle shape up to the end.
- Brush with butter and place on a buttered jelly-roll pan.
- Repeat with remaining phyllo dough and filling.
- Bake 10-15 minutes or until golden brown.
- Cool 5 minutes brfore serving.
Most Helpful
This was such a delicious recipe! I made these for my holiday gathering and everyone loved them. I actually used wanton pastry and using a cookie cutter cut them into medium sized rounds. I baked them in a lightly sprayed mini-muffin tin this gave a sort of flowery croustade appearence. I filled each little flowery cup with brie and bacon topped with a dollop of cranberry sauce and continue to bake until the cups were a golden brown. I have seen this on the BBC done with Puff pastry and fried, but I enjoyed this much more. Thank you for posting this recipe. This is sure to become a holiday favourite!
These were excellent! Even if I did screw up. I accidentally bough spreadable swiss instead of brie (the package looked like brie).....so I just went with it. It was very good....I mixed the spreadable swiss with my homemade cranberry chutney, and mixed it with my mixer, then used my cookie dough dropper to put it on the phyllo dough. very impressive, quick, and excellent flavor.
I made this recipe, but cut the phyllo into 4 and made triangles. They were delicious both warm and cold. I will definetly be making these again; and experimenting with different cheeses. A great Thanksgiving appy! I am so excited to bring these to tonight's big dinner.


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Which way is the best way to learn english better when im in china&im a chinese? i guess u will say the same way as learn Chinese.... RayNKG 26-30, M 1 Answer 1 Dec 27, 2012 in EP SEND TO A FRIEND: Your Response Please respond with authenticity, support, and respect Cancel You can join Experience Project now! Username: Password Email Birthday Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec Gender Select Male Female Trans* Already a member? Sign In By clicking "Sign Up", you confirm that you agree to the Terms of Service of Experience Project, Inc. Login Login to respond Username: Password: Keep me logged in Not a member? Sign Up Sign Up Sort popular recent oldest This might be helpful.

http://www.talkenglish.com/

Best wishes! Best Answer waterbabygal 46-50, F Feb 15, 2013 1 Heart Reply Your Response Please respond with authenticity, support, and respect Cancel


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amazon - News, Features, and Slideshows
An inside look into VMware's new hybrid Cloud strategy
During the past week VMware has been making power play moves in the Cloud computing market to position its offering as the premier enterprise hybrid Cloud computing platform. As it does so, however, analysts question how well the grand plan VMware CEO Pat Gelsinger has put together stacks up with heavyweights of the cloud computing market, most specifically Microsoft and Amazon Web Services (AWS).
Gartner's Cloud showdown: Amazon Web Services vs. Microsoft Azure
Gartner IaaS research director, Kyle Hilgendorf, says one of the most common questions he gets from enterprise customers looking to go to the Cloud is: AWS or Azure?
Cloud giants do battle backed by distinctly different partner networks
When evaluating the marketplaces of the big three public IaaS cloud providers - Amazon Web Services, Google and Microsoft - AWS stands out in terms of the maturity of its platform for partners to offer products and services on top of its cloud. But Microsoft, too, has a formidable partner program that could rival Amazon's in the future, analysts predict.
Here's why Amazon drones may never land at your door
Amazon's ambitious plan to use flying drones to deliver packages is far-fetched, but not just because of technology limitations or air traffic regulations. Amazon's fulfillment center network, as it stands now, is too limited to serve even a tiny fraction of the U.S. in the method described by CEO Jeff Bezos.
Amazon: New analytics tool can scrutinise massive amounts of data
Amazon Web Services this week rolled out a new cloud-based data analytics tool named Kenesis, which can analyze massive amounts of data in real time and be paid for by the hour.
2012: The year in quotes
Some of the most memorable IT-related quotes were uttered in courtrooms this year, which involved a steady stream of legal challenges about intellectual property. In no particular order, these are some of the comments that stuck with us as 2012 winds to a close.
Cloud computing showdown: Amazon vs. Rackspace (OpenStack) vs. Microsoft vs. Google
It wouldn't be a mischaracterization to equate the cloud computing industry to the wild, wild west.
Apple iPad vs Kindle DX: Which is better for education?
If the iPad doesn't succeed as a consumer electronics device--its initial target market--it may find a successful second career as an electronic textbook reader.
Amazon's Kindle for PC app: 10 things to know
Amazon's extending its electronic bookstore onto your desktop. The company announced plans for a Kindle for PC desktop application at Microsoft's Windows 7 launch event Thursday.
Inside Amazon's Cloud: Just How Many Customer Projects?
There's been a lot of discussion the past couple of days about an analysis by Guy Rosen, in which he estimates that Amazon Web Services (AWS) is provisioning 50K EC2 server instances per day. He created this estimate by examining EC2 resource IDs and doing a time-series analysis on how much the IDs are incremented per hour.
Google's move into e-books could be explosive
E-books may have been a niche technology so far, but Google Inc.'s entry into the market could burst the online business wide open.
- Microsoft fixes 36 flaws in IE, Edge, Office, Windows, .NET Framework
- Facebook has just 60 days to change its terms and conditions for French users
- Coming to HP's consumer laptops: Smoother video with AMD's FreeSync
- Obama's cybersecurity agenda bold, but relies on untested funding, experts say
- Microsoft delivers Office 2016 to subscribers on the slow train
- Maxus Worldwide launches new marketing tech consultancy
- Cricket Australia deploys Prime Focus Technologies solution to manage digital content assets
- Why big data is the capital driving the digital age
- 8 ways to avoid fads, gimmicks and shiny martech toys
- What the hell is the difference between ad tech and marketing tech?


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Summer Crafts for Kids
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Patriotic Yarn Wreath
By: Joey Bailey from Created in AWE
1 Comments
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Show your pride during the next patriotic holiday with a simple decorative wreath. This craft uses yarn, so it's easy to work with and allows you to put your own festive touches on it.
- 3 skeins of yarn, in White, Lipstick, and Bright Blue, in I Love This Yarn, Sport Weight
- 14" green floral wreath
- 1 piece of white felt
- Scissors
- A black sharpie
- Paper scrap
- Scrap of ribbon
- Measuring tape
- Tacky glue
Create a pattern for the stars with scrap paper. Mine have a little character, mostly because I couldn't cut out a perfect star if my life depended on it!
Then use your pattern to cut stars out of the felt. My stars were about 1" and allowed for 7 to be placed on the wreath. Space them out as you choose and glue in place.
Begin by measuring the circumference of the wreath. This one is 44". Measure one section to be 1/4 of the total wreaths and mark it. This is the blue section. I chose my remaining, stripes, section to be split into 3" stripes giving me 11 stripes. Measure each strip along the outside edge and mark each stripe.
At the end of the stripe place a dot of glue on the back and cut the yarn about 3/4" past the dot of glue and tuck the end under the last pass or 2.
Take the white, also tucking the the end under the last passes, lay it through the glue, and repeat as with the red.
And finally, end with the blue in the last section as with the stripes.
Measure a piece of ribbon for hanging the wreath.
Tip: take the ends of the ribbon and run them carefully against a candle flame to seal them from fraying. This pic shows how close to get the ribbon to the flame. Any closer and it will turn black.
Tie a small knot and glue the knot against the back of the wreath at the top edge of the blue section and first stripe.
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janquito1 0667931
Sep 23, 2012
I had my class of homeschoolers make similiar wreaths only we put mirrors glued to the backs and the children hung them in their rooms. Wonderful gifts, too!
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114 Airbus, 100 Boeing: Iran on a shopping spree?
114 Airbus, 100 Boeing: Iran on a shopping spree?January 25, 2016 12:46
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Dubai builder Arabtec surges after $545 mln contract award
MIDEAST STOCKS-UAE mixed, Qatar falls in early trade
MIDEAST STOCKS-Markets face further declines after global markets slump
Abu Dhabi's Gulf Capital raises $175 mln for second credit fund
MIDEAST STOCKS-Gulf hit by oil, global equities slide, regional fears
Dubai stock index drops 3 per cent in early trade
Qatar recalls envoy to Iran after attacks on Saudi missions
PRECIOUS-Gold hits 7-week high as worries over China hurt stocks
MIDEAST STOCKS-Emaar drags down Dubai; Gulf markets weak
Saudi Q3 GDP growth edges down to 3.6 pct y/y
Qatar and the UAE were all nerves this June as the two awaited the MSCI upgrade-which was postponed from June to six months later in December. The two were denied an upgrade to 'emerging markets status'
December 22, 2011 3:49 by Eva Fernandes
UAE, Qatar gain momentum in the run up to emerging status verdict
June 22, 2011
UAE and Qatar get another chance at making the grade for the coveted 'emerging market' status on MSCI's index. Will they make use of the six months breathing space?
The UAE and Qatar get to live another six months as 'frontier markets' in the eyes of Morgan Stanley Capital International (MSCI) Index. The news that index provider MSCI will extend the review period for reclassification must come as a sigh of relief for most of the people glued to this issue, Kipp thinks, since it was nearly evident the Qatar wasn't going to cut the muster while UAE was only barely-possibly-hopefully going to make it.
"I don't think investors in either markets were expecting an upgrade so this is a favorable outcome," Arindam Das, head of HSBC's securities services for Middle East, North Africa was quoted in a Reuters article.
So the two countries have got till the end of the year to get their stations in order. By then UAE's Investment Map will have been one month into its November launch, for one. And who knows, maybe Qatar will eventually convince firms to raise the limit for foreign ownership from 25 percent to at least UAE's limit of 49 percent—the MSCI prerequisite.
The MSCI upgrade was postponed to a good six months after which we were all nerves…
December 11, 2011
As MSCI's classification review draws nearer, questions around its impact on the UAE's ailing business performance is in the spotlight. Will the UAE see the ranking as worth the change?
For the most part, it's hard to disagree with analysts. The UAE continues to feel the blows of the economic crisis from a couple of years ago, even know as it prepares for a second crisis that may be brought on by the Euro debt. And while the rating will help put the UAE on the radars of investors around the world, the current circumstances around regulation, business ownership and current market conditions make it less appealing for discerning investors to consider the UAE, compared to say, India, China or even Latin America, which hold promise of cheap labour, and a outlined and established investment regulations and business ownership.
Of course steps are being made to roll out the red carpet for potential business. There's that new Companies Law that was recently approved that sets "a general framework for public joint-stock companies to ensure the rights of all stakeholders, transparency and disclosure of financial statements and the efficiency and integrity of board of directors" –at leastthat's how a Gulf News article described it.
Both UAE and Qatar were denied the ugrade.
High Saudi spending, budget surplus in 2012 - IMF
December 22 2011
Dubai bond rally is modestly positive for 2012
December 22 2011


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Spinach-Artichoke Mini Bites
Mini Italian Shepherd's Pies
Sweet and Spicy Chicken Flatbread
Strawberries and Cream Pie
Sesame-Crouton Asian Chicken Salad
Luscious Artichoke Heart Pizza
Easy to make and delicious, you can't go wrong with these personal-size sweets.
*All breads made with at least 8 grams whole grain. At least 48 grams whole grain recommended daily.
Substitute 1 tablespoon of dark rum for the rum extract.
For an alternate garnish, add chopped chocolate-covered coffee beans to the top of each flatbread.
© 2015 ®/TM General Mills All Rights Reserved


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July 2012 ID by CupkikWatch
©2012-2016 Cupkik
My new ID.. that's all ._.
Came out super cute.
One of the better self portraits that I've seen on this site. The character is cute along with the clothes and hair. I also like that Cupkik went to the trouble of making it look like a photograph. Good show.
That's so Cute!! ^ ^
too cute [:
aww , its so cute . (: favs this .*
That's adorable!
I really like how you draw eyes. They look so soft and sweet
I really like how you draw eyes. They look so soft and sweet
Thank you! It's kind of a change in eyes, I'm kind of always shifting styles a bit, trying to find what I like best.. I like them too : D


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Congress has ordered an investigation into what it says are "skyrocketing costs" of fixing and keeping up machines that scan luggage for bombs at the nation's airports.
Delta to silence Song?
Delta Air Lines is considering dissolving its discount unit Song, although it looks to incorporate many successful elements of that fleet successful, according to a news report published Friday.
Four early-American Thanksgivings
Think you know what Thanksgiving tastes like? Does it involve sweet potatoes with marshmallows or green beans and onion rings? Think again. These four early-American destinations – Plimoth Plantation, Colonial Williamsburg, Mount Vernon and Sturbridge Village – do Thanksgiving right.
World's travel industry braces for bird flu
The world's travel industry says it's already working to ease fears over bird flu, upgrading air filters on planes and stockpiling drugs, hoping to head off a potential disaster.
A hurricane closure
Kim Kolberg reserves a room at a hotel in Fort Myers Beach for the Shrimp Festival. After a hurricane hits, the toll-free reservations line assures her the property is open, but when she gets there, it's closed. Kolberg has to scramble to find a room at a sister property – and it's more expensive. Should she have to pay the difference?
Weary Floridians pick up the pieces
Millions of Floridians are without power Wednesday, two days after Hurricane Wilma plowed across the peninsula, and some could be in the dark for weeks.
Wilma kills 10, leaves 3 million without power
From Cancun to Key West and Marco Island to Miami, people are mopping up water and sweeping up debris in the aftermath of Hurricane Wilma, which is now churning in the Atlantic.
Wilma makes landfall in Florida
Hurricane Wilma, a 125-mph Category 3 storm capable of extensive damage, made landfall Monday at near Cape Romano, Florida, the National Hurricane Center said.
Bankrupting in-flight security
Airline managers flying under bankruptcy protection are talking about outsourcing flight attendants' jobs on international flights to crews from China, Mexico and Asia. Don't let them do it. Cabin security is at stake.
Hurricane Wilma lashes Yucatan
Hurricane Wilma was pounding Mexico's Yucatan Peninsula early Friday, with the popular tourist cities of Cozumel and Cancun directly in the deadly storm's path.


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How the permissive society led to the coalition of the super-rich
Over at Standpoint magazine Nick Cohen is starting his very own "Anyone But Balls" campaign, pointing out (among many reasons for not wishing Ed Balls as leader of the Labour Party) that the last thing Britain needs is three party leaders who all went to public schools. It would just prove that Britain, as Cohen also argues in his latest Observer column, is more divided by education than ever before.
But while he has a point when he says that Clegg, Cameron, Osborne, Laws, Huhne and Letwin are all sons of rich men who sent their kids to the best and most expensive schools in the country, there is an upside to all this – the creation of an almost entirely privately-educated government is finally waking people up.
We can now fully see the effects, 40 years on, of Tony Crosland's tragic education reforms: a country once again ruled by public schoolboys, and a state-educated underclass who don't have the discipline, stability or social skills to function at the most basic level.
Crosland's reforms were based on a fundamental mistake, the born-free fallacy which, as Roger Scruton says, "tells us that human freedom is a natural gift, that we are born to enjoy it, and that we lose it through the laws, rules and hierarchies of social life." None of which is true, as anyone who attended a comprehensive will tell you.
Private schools were the one area of the education system that escaped this child-centred ethos, which put children with low levels of self-discipline and home education at an even greater disadvantage than before. Meanwhile, as our own Toby Young points out, the cheerleaders of the comprehensive system send their school to private, grammar or faith schools, where old-fashioned Hogwartian educational rigour remained in place.
It is not just the abolition of most grammar schools that hurt social mobility; I genuinely believe that allowing schools to right to use limited corporal punishment would do more to reduce social inequality than all the billions wasted on income redistribution under Gordon Brown. Like with all of the great progressive social reforms of the 1960s and onwards, its abolition benefited the rich and harmed the poor.
Take crime, which thanks to more lenient sentencing has gone up on all fronts in the past 40 years, although inventive statistic-keeping in the past 20 years has made it harder to assess just how much. Although everyone suffers a bit more, crime is still a great respecter of class.
As Ferdinand Mount writes in Mind the Gap, his excellent study of class division, less than one per cent of households, mostly in the poorest areas, account for 42 per cent of all burglaries. I seriously doubt any of Chris Huhne's seven homes are in that bracket, which might explain why he's so in favour of reducing sentencing levels even more.
The same goes for the liberalisation of divorce laws and the other aspects of sexual freedom, which allows middle-class people to live freer, more varied lives, but devastates the poor and their children. For example if any of my nice liberal middle-class friends were to divorce it would not have the same impact on their children as it would on, say, children in Tottenham or Peckham whose parents divorce. Because of their education levels and background, their wives would be unlikely to end up bringing home a 6'4" psychopath who collected SS knives in their spare time and ended up sexually assaulting or murdering their children.
They'd be unlikely to end up homeless as a result – as huge numbers of working-class men are following divorce – and having to beg for a house on the council waiting list (and now finding themselves competing with people from around the world because of that totemic post-war liberal ideal, mass immigration, which has done more than any other idea to make this country even more unequal).
The progressives are unable to admit how much damage they've done to the poor, their answer being to put more money into compensating them financially, which is akin to manufacturers of high-strength alcohol giving money to addiction charities and then congratulating themselves.
It is no accident that, a generation after the permissive society was instigated by Harold Wilson's government, we now have a cabinet consisting almost entirely of the privately-educated, super-rich.
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missile defense shield
The Senate will keep thousands of "earmarks" in a spending bill, and President Barack Obama denied a report that he offered Russia a deal on a planned U.S. missile shield. Jim Lehrer recaps the day's other news headlines. Continue reading
Secretary of State Condoleezza Rice and Polish Foreign Minister Radek Sikorski signed a deal Wednesday to build a U.S. missile defense base in Poland. The agreement infuriated Russia, which warned of possibly attacking the former Soviet satellite. Continue reading


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Reviews - Osborne Hotel4
Hesketh Crescent, Torquay, TQ1 2LL
Price From £109View Rooms
Customer Reviews
Our reviews are from genuine LateRooms.com customers. We verify that the customer has stayed before leaving a review.
Very Good
89% would recommend it to a friend
Customer service
Food quality
Room quality
Osborne Hotel
Great location beach yards away town 10 minute walk.
Rooms lavish, huge bed and very comfortable. Flat screen TV in room too very pleased.
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filthy dirty hotel
room dusty, carpet sticky and not cleaned.
I stepped on an old toenail. Cobwebs in the corners of the windows. Food not very good and staff wasn't sure about what was or was not available.
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Great outlook from room over Meadfoot Beach.
Food excellent and service very good. Bedroom probably due for a refresh of paint and chairs in room very tired.
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nice relaxing break.
from the moment we arrived all staff was very polite & accommodating , rooms was well equipped with tea & coffee plus a nice supply of biscuits..
room was clean & well arranged to accommodate our stay. food was excellent ; with the breakfast to keep you going all day. overall a well run hotel, in which to enjoy a break anytime of the year.
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Perfect break
We were blessed with brilliant weather which enhanced the fantastic views from our room (Osborne).
The facilities were first class and all the staff were courteous, making us feel most welcome. Nothing was too much trouble. The hotel is in a delightful setting with excellent facilities and I would strongly recommend it to anyone wanting a true British holiday with traditional elegance.
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Best Fish & chips of my life! (And lots of other good things)
I'd worked all day and then flown and drove down for work the next day.
I was a bit frazzled to say the least. The hotel & view took my breath away. I was greated by a wonderfully warm and informative receptionist who told me about all the facilities. I had a lovely swim in the indoor pool, then the best fish &chips of my life and then bed, woke feeling wonderfully refreshed and a great breakfast and thoroughly ready for work. My only very slight gripe is the wifi didn't support me streaming Netflix and I'm in the middle of a box set (but that would be really digging deep to find a gripe)
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Wonderful Hotel and great location
We had a brilliant stay.
Lots to do everyday. The hotel is situated on the outskirts of Torquay a lovely quiet location @ Meadfoot beach. Easy access into Torquay by bus, taxi or walking. We visited Dartmouth by Steam train & ferry, Dawlish by rail, Babbacombe (Beautiful) Paighton Zoo, lots to do. If you don't want to go out, the hotel has an indoor and outdoor pool, a gym and two places to eat - restaurant @ Brassiere. The hotel had the same great service and staff as last year, but the choice of menu has changed to a monthly rotation option. So if you don't like something in the restaurant menu you had to eat in the Brassiere, which limited your choice a bit. We stayed in the Lewis room which has an excellent sea view and has a pair of binoculars for your use. A good comfortable bed and seating area. Our only niggles were that the water pressure for the shower is quite low, but it had a bath so okay and one of the sliding wardrobe doors was difficult to open fully. An excellent hotel and would recommend it to anyone for a relaxing break with plenty to do.
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With the hotel having 4 stars, I would have expected the extractor fan in the enclosed bathroom/toilet to be working, and perhaps it would have been have been essential to have a loo brush provided.
It was a lovely room, but being the beginning of the summer season, I would have expected the carpet to have been cleaned.
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Excellent food
Lovely hotel with great views.
Food was excellent - the dinner was well served, hot and tasty, and the breakfast was perfect. The rooms were great, the corridors were a little tired but the rest of the communal areas were well kept. I didn't have chance to use the leisure facilities so can't comment on them.
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- Cost: $99.95 set up fee and monthly payments as low as $59.95/mo.
- Over 20 Years of Experience
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- Over 4,800,000 Items Removed in 2013
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Jouer Lip Gloss in Glisten
1 review
100% would repurchase
Package Quality: 5.0
Price: $$$
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A hobo who enjoys the gastronomical delights of pie.
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Heather: What an Incredible Season!
November 3, 2015 • 12:30 PM ET
Wow! What an incredible season! There have been so many twists and turns and changes in relationships. I actually feel like they are not frivolous, but a quantum shift in friendships to what they actually should BE, versus what they were. ...Read more
Meghan: My Heart Also Aches for Tamra
October 27, 2015 • 12:28 PM ET
Part One of the reunion was pretty low-key, but now Part Two has started to dive into some more of the drama! Yikes! The best part about this week was that Jimmy joined me on the couch and I'm really glad the audience got to see a more relaxed and...Read more
Vicki: I Never Betrayed Shannon
October 16, 2015 • 11:34 AM ET
As I write this blog, I have so many mixed emotions, but mostly it's sadness and betrayal. I don't know how or why the season ended the way it did, but all I want to share with you at this time is my perspective and what I went through this year...Read more
Tamra: The Truth Always Comes out
October 14, 2015 • 3:59 PM ET
I am so excited to share yet another amazing moment in my life. The eight years I have been on the RHOC I've had my ups and downs and you guys have been there to see most of them. Getting baptized was something I did not think would ever happen on...Read more
Lizzie: A Lot of Stuff Doesn't Add up
October 13, 2015 • 9:52 PM ET
I wasn't going to write a blog this week. I was asked this morning for my blog and woke up to Meghan causing drama on Twitter, "fact checking" and doing a roll call for everyone that knew of David's affair. It really rubbed me the wrong way. So, I...Read more
GIF Recap: Baptism by Fire
October 13, 2015 • 12:56 PM ET
Sadly, another season of The Real Housewives of Orange County has come and gone. Luckily for us, GIFs remain forever! Here are 9 GIFs from the #RHOC Season 10 finale to help get you through this tough time and pump you up for the drama that the...Read more
Shannon: Vicki Was Just Being Cruel
October 12, 2015 • 10:01 PM ET
This is quite a finale. Outrageous at times. I am very proud of Tamra's decision to get baptized. Tamra and I each went through our own horrendous experiences last year and we both found our way to the Lord to help navigate us through. We...Read more


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Of course before you start any testing or promotion you need to ensure your measurement systems are in place. The more you understand about what your customers need and how they react the more effectively you can market to them. Both Google and Yahoo! provide good measurement of PPC campaigns. But, in addition, you should have a general web statistics package. Google Analytics is an excellent free service which should be the automatic choice for small companies.
While setting up your website and determining your marketing strategies, don't forget to save all the information you are collecting.
Visitors want quick information but also the ability to go into detail when they choose. Search engines mainly index text when the human might get information quicker from a picture. You, as the owner of the website, are anxious to get the sale, or lead, that is your major site objective and are not very interested in providing information that the visitor may like but that does not directly lead to a sale.
The majority of web designers start from a background in the graphic arts. So your page will look nice but you need to ensure it fulfils the business goals. Start from the web planning template but, then, see here suggestions for your design brief.
Optimising your website
You should include in the design brief a requirement that all significant pages be optimised for search engines. However this is a requirement that goes beyond pure design. Whoever is writing the content is equally responsible for ensuring the search engines get the 'right' content.


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BIEC Result 2014
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Bihar Intermediate Education Council has been in existence for a long period they had done in numerable activities concerned with the education process of the Class 11th & 12th students.
Name of the Organization
Bihar Intermediate Education Council
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BIEC Result 2014
How to check BIEC Result 2014
- Students must first open the site www.educationbihar.gov.in
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- On this page move to "Bihar Board News"
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Sometimes ME/CFS emerges after mononucleosis, or glandular fever. Simon McGrath shares results from a long-term follow-up study from Haukeland University Hospital in Norway...
Discuss the article on the Forums.
Dec 20th: High Noon for Ampligen! FDA Advisory Committee Decides Ampligens fate in live webcast
Discussion in 'General ME/CFS News' started by Cort, Dec 18, 2012.
Page 3 of 9
Page 3 of 9


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Just wondering if there are any other AU clydes on this board. I saw a guy this morning with a bright yellow jacket on a Trek 1000 I think. I was curious, I am always looking for someone new to ride with.
Just wondering if there are any other AU clydes on this board. I saw a guy this morning with a bright yellow jacket on a Trek 1000 I think. I was curious, I am always looking for someone new to ride with.
War Eagle! Unfortunately, I am in North Alabama and I'm betting you are on the plains. Good luck finding some riding companions!
Faster than a sundial.
Yes, I'm in Auburn. I'm finishing up my Engineering degree in August and I have just started riding a road bike in the last 5 months. I have a couple of people I ride with and we are always looking for more people to join our group. So far I've lost about 40 lbs and most of it can be attributed to my work in the saddle. I thought about putting another thread in the Road forum but I am not sure I could keep up with most of them anyway.
You wouldn't happen to be in Huntsville would you? I might be moving up there after I graduate and I have been wondering how friendly it is to cyclists.
What kind of rides do you guys do? Hills? Long miles? And where?
I'm in Opeilka. I'm quite comfortable with doing my solo rides for now. Mostly because I'm concerned about skill level and dragging other down. And to this point my longest ride is jut over 16 miles. I ride a Fisher MTB. I usually only ride on weekends.
I'm in Decatur, but there's a club in Huntsville I plan on contacting soon to get in on some of their regular rides. It's www.springcity.org .Check them out. Looks like a pretty decent club from their site. Like Delusional Dude, I'm still working on building leg strength, commuting and riding solo for now. Hope to ride with you some day if you make it up here! I work swing 12's so I'm off weird times throughout the month compared to 9-5'ers.
Faster than a sundial.
DelusionalDude -
We usually ride between 20 and 35 miles depending on how much time we have to work with. We average between 16 and 18 mph so far but we are getting a little faster. Sometimes we ride with my buddies girlfriend and we go a bit slower but we are always willing to slow up a little for new people. We are by no means in top physical condition. If you want to go for a ride shoot me a PM with your phone # and we can get together.
seenoweevil -
I'll let you know if I make up there. It will probably be August before I know for sure.
Thanks for the offer, but I am nowhere near ready to ride with you guys on a regular basis. My goal for now is to work up to riding the Saturday Breakfast social ride that leaves from the high school. So far my longest ride is about 16 miles. By summer, I'll work up to riding a lot more miles per trip. I'll keep an eye out for you on the board, and if I get a mega dose of confidence I'll try to get a ride with you.
Sounds good to me. Take your time and give me a shout if you decide you want to go for a ride. Like I said, I'll take it slow.
I'm not a clyde, but I'm a cycling noob in Auburn.
I am in the Huntsville area, and a member of the Spring City Cycling Club. I don't make it to a ton of group rides because of my schedule, but they are a great group. Seenoweevil, you might be interested in the RAM (Ride a Metric) Training Series that is starting back up soon. It is designed to get you from almost nothing to a Metric Century in about 5 months. They ride most every Saturday morning and start with a ride of about 7 miles around a 10-12 mph average. They increase the distance a little each week all the way to the All You Can Eat Century in Huntsville in September. I did it last year, and it was a great intro to group riding. A lot of the rides start from the Greenbrier area, so they are just as close to Decatur as they are to Huntsville. The information is on the website at www.springcity.org. If you are interested, let me know. I plan on hitting a few of the RAM rides just to help out in return for getting to do them last year.
I'm in Pennsylvania, but they say everything between Philadelphia and Pittsburgh is Alabama. In that case this is the thread for me.
WOW, I did not realize that there were so many Alabamians on here.
I am in the Birmingham area. I actually live out in the Trussville area around Margaret.
Cool to know there are so many Alabamian riders here. Maybe we will all run into each other at Oak Mountain some time.
Clyde in Athens, AL - just getting back on my bike after 18 months of vegetation and over work.
I'm an Auburn Grad Clyde, live in Clanton, AL
If I could only redo my college days I would have spent awhole lot more time on my bike.


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Top Definition
Better-than-average in sexual activities. Exceedling skilled at the art of sexual intercourse and/or foreplay. Provides extreme pleasure and enjoyment to the other (or others) involved. Often respects the partner the next morning.
Glenn is one heck of a love-maker, he sure is a Greatinbed kinda guy!
by Matt Roveberg December 15, 2006


text: Okay, I'm 99% sure I've got the right answer here, but I just wanted to make certain before I send my assignment in. It's the last question and has been bugging me for the last few days until I had an eureka moment just a few minutes back. (In case you're wondering, I'm doing my studies by correspondence, so other than course notes and textbooks borrowed from the library I have just the internet and my brains (hah!) to aid me) 1. The problem statement, all variables and given/known data A baseball diamond has sides 27m long. A player is running from 2nd to 3rd at a speed of 9m/s. When he is 6m away from 3rd, at what rate is the player's distance from home plate changing at that instant? 3. The attempt at a solution x = distance from home plate to 3rd = 27m y = distance from player to 3rd = 6m z = distance from player to home = 27.66m (using pythagoras) speed of player is change of y over time: dy/dt = 9m/s [tex]z^{2}[/tex] - [tex]y^{2}[/tex]= [tex]x^{2}[/tex] differentiate with respect to time: d/dz[tex]z^{2}[/tex] - d/dy[tex]y^{2}[/tex]= 0 (since x doesn't change over time) dz/dt*2z - dy/dt*2y = 0 divide by 2: z*dz/dt - y*dy/dt = 0 sub the above (z, y, dy/dt) into the equation and solve: dz/dt = 1.95m/s If this ain't correct, please tell me quickly as I need to post my assignment off asap!


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Harry Potter's Severus Snape's Story Told in Chronological Order
If you're a Harry Potter fan this video is mindblowingly awesome.
If you're a Harry Potter fan this video is mindblowingly awesome.
Allow me to begin my stating a simple, yet embarrassing fact.
I've never seen any Terminator movie. Nope. Not one. Never ever.
All I know is one 3-word phrase...
Both parents and kids rejoice! The trailer is here for The Lego Movie! They promising it'll be the best movie ever assembled. When I first saw it pop up on YouTube, I thought it was a joke. I've always enjoyed the Lego shorts...
Movies are as much a part of our culture as football, pizza and cars. There have been some terrible and amazing movies in the past 100 years. Here's 250 of the best according to IMDB in 2 and half minutes. How is that possible? TONS of editing.
Lindsay Lohan finally signed on to play Elizabeth Taylor in her upcoming Lifetime biopic. Her names been thrown around for awhile because she was really pushing for the part, but apparently the movie producers wanted her all along...
I'm a total closet Dead fan! If you ever take a road trip with me, you'll likely find yourself jamming to Sugar Magnolia or Touch of Grey! In fact, I have a Grateful Dead dancing bear on my ankle and it's my only tattoo! I may have had a bit of fun in college, but I digress! I'm totally excited! You can see the Grateful Dead right here in Shreveport!
So I had my trusty old school (crappy quality) camera with me last night. And got some peoples reactions to 'The Hunger Games'. More people talked with me off camera because their make up got messed up from crying. See the reviews here!
Hilarious more like it ... everybody loves making fun of Star Wars Episode I ... for a very good reason. The original Star Wars was amazing. It was the Avatar of it's time. Then Episode I came out and was a 20 year disappointment for everybody. I digress here's a video making fun of the only thing decent about Ep 1: light saber battles.
Now with more aliens, more explosions and more Rihanna ... sweet.
Old school Willy Wonka staring Gene Wilder. It had magic, songs, and a trippy acid boat ride thing.
Srslysirius took the last scene and made a song out of it. I haven't heard a song remixed from a movie that was so tight since someone remixed Christian Bale's trip out on the Terminator Salvation set.
It's only fitting that after the 2012 Oscars, Jimmy Kimmel would debut a trailer for the most epic, star-studded movie of all-time. It's over eight minutes long, stars 2012 Oscar nominees George Clooney, Gary Oldman, and Meryl Streep plus Matt Damon, Jessica Alba, Samuel L. Jackson, Charlize Theron, Tom Hanks, Cameron Diaz and Gabourey Sidibe as Black Hitler (who threatens Earth while riding on a meteor). It is, as Kimmel himself put it, the "greatest movie ever made."


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Rudi's Organic Bakery® Shows Off Their Best Buns Yet
BOULDER, Colo., June 12, 2014 /PRNewswire/ -- Summer is officially on the brain. Temperatures are warming and Rudi's Organic Bakery® brand is ready to fire up the grill with a tasty twist on the classic bun with their new Organic Pretzel Rolls."People love our organic soft pretzels and our organic hamburger buns, so it made sense to combine the two just in time for grilling season," said Denise Day, senior marketing manager for Rudi's Organic Bakery, Inc. "Our new Organic Pretzel Rolls offer that beloved pretzel texture and taste, but with all of the goodness of high-quality, organic ingredients that people love."The new Organic Pretzel Rolls are the only certified USDA Organic pretzel rolls on the market. They feature that classic pretzel texture marked by a soft and fluffy inside and chewy and satisfying outside. With just 10 non-GMO ingredients and a great taste, Rudi's Organic Bakery® Pretzel Rolls are practically a no-brainer for a successful backyard barbecue. "Pretzel Rolls were on my list of the top food trends last year, so I'm thrilled to see that Rudi's is offering the very first organic version. With grilling season just around the corner, I can't wait to use Rudi's Organic Bakery® Pretzel Rolls for barbecues and picnics all summer long," said Frances Largeman-Roth, registered dietitian and best-selling author who works with Rudi's on recipe development. "They're certified USDA Organic and a great choice for families." To get taste buds tingling, Largeman-Roth developed a yummy recipe with rainbow slaw and barbecue chicken made to be served open-face on a Rudi's Organic Bakery® Pretzel Roll.
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Phone Number(▒▒▒) ▒▒▒- ▒▒ 78
Reviewed2 Reviews
Offline IDPersonal Info
Hey, I'm Monika!
Philadelphia, Pennsylvania, United States · Member since June 2010
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I'm a lover of museums, theatre, crafts, art and great food, as well as the journey itself to new locations. I explore most often with my friend and partner (and husband) of many years. We love vibrant cities, especially, and love to experience the rhythms of days and nights on different streets, under sunshine and streetlights. We travel lightly, and will be respectful of your home and your neighbors!


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Walton High Portal
Security Update
Please note that the Security Certificate has been changed as of 29/10/08. You should download and install the new certificate from the link and the bottom of this page before attempting to use any links below.
The links below for the Leading Learning Portal will require a logon (see animation below) to gain access to Walton High's Network System.
Staff Portal
Security Certificate
If you require the Walton High "Security Certificate 2010" Then click here to download.
Security Certificate Installation Instructions
Yamaha courses offer the highest quality and the best value in music teaching, Free Taster Session, phone and book a free taster lesson at our Yamaha Music Point... more
Walton High is able to take online payments via WisePay for cashless catering, trips etc. If you already have your username and password and you would like to use this service, please click here
Our main purpose is to ENHANCE the quality of life at Walton High from a student perspective. We hope to ensure that STUDENTS' OPINIONS are considered in the day to day administration and FUTURE plans of the School...more


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I don't get twitter. I'm on it and occassionally read some of the things I follow. I have friends that say it's where they get all of their news from but I don't think it's any easier than going directly to the new's sites and setting alerts. Alot of the tweets are seem to be blow hards who like to hear themselves talk are pumping one thing or another; but that may be a function of who I follow. The thing for me is it doesn't make jack in the way of earnings. FB at least has several billion in revenue. Plus, most of the people I know who retail shop on the internet are women and I don't know that twitter has as many women users as does FB. I'm thinking a big drop by the end of next week. Probably in the high 20's or low 30's. Again, they just don't make money right now and the cost for future potential earnings is excessive compared to other options.
I don't get twitter and I am a user. I go on it a few times a week. Most of the individual I follow seem to be blowhards pumping one thing or another. That could be more of who I'm following than anything. Some of my friends say they use it to get their news. It's just as easy for me to go directly to the newssite and set alerts for what I want to know.
Plus, Most of the retail internet shoppers I know are women and most of the twitter followers are companies or men, again maybe a function of who/what I follow. Twitter has income in the millions and Facebook in the Billions. I see it dropping in price to the high 20's low 30's and thats probably overvalued.
"$0.01"....penny stock...until they make a profit.
Twitter is no better than a paper magazine from the 80s...there is no genuine value for the money spent ...the current price is purely a "PUMP and DUMP" strategy well executed.
So if you are into arbitrage or own Goldman Sachs shares...you are real winner!! Shareholder who just paid premium for this stock will dis the stock by March! Guaranteed!
Content engaging our readers now, with additional prominence accorded if the story is rapidly gaining attention. Our WSJ algorithm comprises 30% page views, 20% Facebook, 20% Twitter, 20% email shares and 10% comments.
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I Declare War
- Studio: Drafthouse Films
- Release Date: Aug 30, 2013
Critic Reviews
- Critic Score
- Most active
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There's social commentary in all of this, but it takes a back seat to a surprisingly compelling narrative of the two combating teams.
The directors (Lapeyre also wrote the film) have gathered a terrific bunch of young actors for the film, which plays at times like a "Lord of the Flies" knockoff but also has something original to say.
It's engrossing, violent, frightening and funny in the ways it captures the way kids speak with no adults around, and the way kids act when society's rules take a back seat in time of war.
The narrative meanders on occasion, the conceit can seem repetitious, the editing is loose. Nevertheless, buoyed by the naturalism of its exclusively young cast, the picture effectively gets into your head and under your skin.
Exciting and thoughtful, scraped free of the empty provocations of the wicked-pixie Hit-Girl scenes in Kick-Ass, I Declare War offers movie thrills—smartly plotted betrayals and escapes—as well as its share of disappointments.
Co-directors Jason Lapeyre and Robert Wilson balance humor and fun with a little fear in a thoroughly accessible way.
I Declare War holds off as long as it can before dumping its emotional payload. Until then, the film gets uncomfortable laughs from the games children play, and play for keeps.
In the end, I Declare War is both enthralling and a little frustrating in its refusal to fit neatly in any box. Its unpredictable tone clicks back and forth between the comical and the serious like the safety catch on a firearm.
The problem, mainly, is that Lapeyre's kids are stock types: runts, bullies, toadies, a girl with a big crush. In essence, they are kids'-movie tropes pretending to be war-movie tropes — one layer of generic material being used to cover another.
Imagination is what these filmmakers could use more of, as their ingenious concept doesn't develop much beyond a gimmick.
The film rarely takes us past its rather obvious conclusions about the potential bestial nature of kids and how that may translate to the larger battlefields.
A crude sketch of a film that could barely withstand a short-form, but instead has been stretched to agonizing feature length by directors Robert Wilson and Jason Lapeyre.
Unfortunately, despite its good central idea, Lapeyre and Wilson's execution is disappointingly poor.
I Declare War is like high school English class, rife with confusing symbolism and full of sound and fury that ultimately signifies nothing.
User Score
Generally favorable reviews- based on 9 Ratings
User score distribution:
Positive: 0 out of 2
Mixed: 1 out of 2
Negative: 1 out of 2
Jun 2, 2014Una pelicula que muestra como viven algunos jóvenes que tienen muchas libertades de ver de hacer lo que quieran. buenas actuaciones pero creoUna pelicula que muestra como viven algunos jóvenes que tienen muchas libertades de ver de hacer lo que quieran. buenas actuaciones pero creo que hay una parte donde se vuelve muy lenta como unos 10 minutos .… Full Review »
Aug 30, 2013I could almost forgive some of the violence and racial slurs if the film had been fun or had an important message, but this film does neither.I could almost forgive some of the violence and racial slurs if the film had been fun or had an important message, but this film does neither. I enjoy films involving kids in a much more adult themed way such as Kick Ass or kids involved in fun adventures such as Goonies. This film left me cold to the point where it's almost offensive. D… Full Review »


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"The Hoax Exposed" PROFESSOR GIVES COORDINATES OF PLANET INBOUND TOWARD EARTH ! The Hoax Exposed http://www.turnerradionetwork.com/news/237-pat UPDATE- Nibiru 'Astronomer' Hoax Exposed http://beforeitsnews.com lternative/2014/01/nibiru-astronomer-cover-up-found-footage-claim-2885652.html Department of Astronomy The University of Texas at Austin. http://www.as.utexas.edu/~sj/ FAIR USE STATEMENT This video may contain copyrighted material the use of which has not been specifically authorized by the copyright owner. This material is being made available within this transformative or derivative work for the purpose of education, commentary and criticism, is being distributed without profit, and is believed to be "fair use" in accordance with Title 17 U.S.C. Section 107. For more information go to: http://www.law.cornell.edu/uscode/text/17 If you wish to use copyrighted material from this video for purposes of your own that go beyond 'fair use' you must obtain permission from the copyright owner. Any attempt to misuse copyright to intimidate, harass or censor this video or its author will be vigorously defended. NOTE: The author of this video uses http://www.counterdmca.com/ as an 'Agent of Service' to respond to DMCA takedown notices, and his personal information will not be divulged in the counter-notice. The main purpose of science is to investigate the unexplained, not to explain the uninvestigated. Dr. Stephen Rorke. Sangstar1 Researchers Defending Truth and Debunking Deceit. AKA Sangstar1 serving you better Videos Presentations TruthResearchers. Sangstar1 was created by the Late, Mr Correa Snr. My name is Sergio Correa and I am the co-founder of Sangstar1 Videos Presentations and News Channel. At SANGSTAR1, we believe that your children safety from internet Predators Scammers are extremely important. Be careful, so do not put your child at risk, and keep them inform of the dangers on Internet blogs, emails, and sharing Mobile numbers, address on the internet. Cosmofobia/Cosmophobia, this symptom applies to people that are afraid of that human knowledge, religion and culture came from ancient astronauts. Sangstar1 Videos Presentations TruthResearchers. https://www.youtube.com/user/sangstar1


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July 22, 2014
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Missouri lost a lot with the departures of Michael Sam and Kony Ealy. For the defensive line to be as successful in 2014 as it was a year ago, the Tigers are hoping a pair of talented freshmen can step up. ...More... To continue reading this article you must be a member. Sign Up Now!
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IIT Bombay M.Tech Admission 2015 on basis of GATE results is ongoing. M.Tech Admission 2015 in IIT Bombay shall be done on the basis of GATE result and further rounds of selection. B.Tech degree holders with more than a certain CGPA from the Indian Institute of Technology, Bombay are exempted from GATE. Get here complete details of IIT B M.Tech Admission 2015 such as application form, shortlisting procedure, cut offs, and other information.
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Publications (13)111.47 Total impact
Article: Parathyroid hormone effects on signaling pathways in endothelial cells vary with peptide concentration[Show abstract] [Hide abstract]
ABSTRACT: We have previously reported that parathyroid hormone (PTH) has specific effects on a human umbilical vein endothelial cell line. Further studies were performed to characterize the signaling cascades initiated by PTH. We report that PTH induced the appearance of voltage sensitive calcium channels. Furthermore, PTH increased ceramide but not diacylglycerol content. Since elevations in [Ca(2+)](i) and phospholipid turnover are signals for the activation of protein kinase C (PKC), the cells were screened for PKC isoforms. PTH induced a redistribution of the PKCepsilon to the particulate fractions of cell homogenates. In summary, PTH induced PKC translocation through a calcium-phospholipid pathway in an endothelial cell line.
Article: Functional parathyroid hormone receptors are present in an umbilical vein endothelial cell line[Show abstract] [Hide abstract]
ABSTRACT: Acute parathyroid hormone exposure induces vascular smooth muscle relaxation. In contrast, continuous infusion of parathyroid hormone leads to vasoconstriction and an elevation of blood pressure. Despite the known effects of parathyroid hormone on vascular smooth muscle, possible direct effects on the vascular endothelium have not previously been investigated. Using a human umbilical vein endothelial cell line, we found that parathyroid hormone increased both intracellular calcium and cellular cAMP content in these endothelial cells. Furthermore, exposure of these cells to increasing concentrations of parathyroid hormone stimulated both [(3)H]thymidine incorporation and endothelin-1 secretion. Parathyroid hormone/parathyroid hormone-related peptide receptor mRNA could be detected at low levels in these cells. In summary, these data demonstrate that endothelium-derived cells contain functional parathyroid hormone receptors. The potential physiological role of these receptors remains to be determined.
Article: Diacylglycerol production, Ca2+ influx, and protein kinase C activation in sustained cellular responses
Article: Diacylglycerol Production, Ca2+ Influx, and ProteinKinase C Activation in Sustained Cellular Responses
Article: T-type calcium channels in adrenal glomerulosa cells: GTP-dependent modulation by angiotensin II[Show abstract] [Hide abstract]
ABSTRACT: With the use of whole-cell and single-channel current recordings, we have examined in more detail the site of action of angiotensin II (AII) on multiple populations of voltage-gated calcium channels in bovine adrenal glomerulosa cells. AII (10 nM) enhances whole-cell T-type calcium channel current and increases the activity of single T-type calcium channels in cell-attached patch recordings. The AII-induced enhancement of whole-cell calcium channel currents is dependent on the presence of internal GTP and can be inhibited by the competitive AII-receptor antagonist saralasin (1 microM). These results show that AII augments the T-type calcium channel current in bovine adrenal glomerulosa cells.
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ABSTRACT: Two populations of voltage-dependent Ca2+ channels, T-type and L-type, are present in bovine adrenal glomerulosa cells. Activation of these channels by cell depolarization with the resultant increase in Ca2+ influx may be one way in which agonists regulate aldosterone secretion. In addition, these channels may be the site of antagonist action. In the present study, we have demonstrated that atrial natriuretic peptide (ANP), an antagonist of aldosterone secretion, alters only the voltage dependence of inactivation of the T-type channel while enhancing the voltage dependence of activation of a subpopulation of L-type channels. These patch-clamp data, which demonstrated contrasting effects of ANP on the activity of T- and L-type Ca2+ channels correlated with changes induced in cytosolic calcium [( Ca2+]i). In the weakly depolarized cell, ANP (greater than 30 pM) lowered [Ca2+]i, in contrast to the strongly depolarized cell, in which ANP (greater than 10 pM) raised [Ca2+]i. Similar alterations in the level of [Ca2+]i in the stimulated cell were induced by the Ca(2+)-channel blocker nitrendipine and the L-type channel agonist, (-)BAY K 8644. With increasing concentrations of extracellular K+ (3.5-60 mM) the rate of aldosterone secretion rose nonmonotonically. ANP inhibited secretion over this broad range of K+ concentrations; however, its potency as an inhibitor of secretion was diminished in the strongly depolarized cell. These data are discussed in the context of a model that proposes a role for sustained Ca2+ influx in cell activation.
Article: Modulation of Ca2+ channels by atrial natriuretic peptide in the bovine adrenal glomerulosa cell[Show abstract] [Hide abstract]
ABSTRACT: In the bovine adrenal glomerulosa cell, calcium influx through voltage-dependent calcium channels is critical to maintaining an aldosterone secretory response. In patch clamp, atrial natriuretic peptide (ANP) inhibits T-type calcium channel current yet stimulates L-type calcium channel current. In the present study the channel effects of ANP observed in the patch-clamp configuration were extended and related to populations of cells. We observed the following. (i) The effect of ANP on T-channel current resulted in the reduction in the open state probability. ANP decreased the mean open state duration from 14.2 to 1.8 ms/sweep. (ii) In the weakly depolarized cell stimulated by 8 mM K+, ANP reduced the level of aequorin luminescence (a measure of cytosolic calcium) and completely inhibited the stimulated rate of aldosterone secretion, returning it to prestimulation values. These effects are consistent with a decrease in net calcium channel influx and the reported inhibition of T-channel current. In contrast, the calcium channel blocker, nitrendipine, which at low dose selectively blocks L-type calcium channel flux, only slightly reduced luminescence, and partially inhibited the sustained secretory response. (iii) In the strongly depolarized cell, stimulated by 60 mM K+, ANP increased the level of aequorin luminescence consistent with an increase in net calcium channel influx and the reported stimulation of L-channel current. These results indicate that under physiological conditions the inhibition of T-type calcium channels may be involved in the inhibition of the aldosterone secretion induced by ANP.
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ABSTRACT: Atrial natriuretic peptide (ANP) inhibits the secretion of aldosterone stimulated by any of these major physiological agonists: angiotensin II, adrenocorticotropic hormone, or K+. The stimulatory actions of each of these agonists depend on calcium influx through voltage-dependent calcium channels. Because two types of calcium channels have been previously described in bovine glomerulosa cells (T- and L-type), the patch-clamp technique was used to evaluate the effect of ANP on each voltage-dependent calcium channel type. ANP was found to differentially modulate these two channel types, stimulating L-current while inhibiting T-current. Inhibition of T-current resulted from a shift in the voltage dependence of inactivation to more negative potentials within the physiological range. These results indicate that the ANP-induced inhibition of aldosterone secretion may be partially mediated via a reduction of the calcium current through T-type channels.
Article: Nimodipine block of calcium channels in rat vascular smooth muscle cell lines. Exceptionally high-affinity binding in A7r5 and A10 cells[Show abstract] [Hide abstract]
ABSTRACT: Calcium channel currents were studied in the A10 and A7r5 cell lines derived from rat thoracic aorta muscle cells. The whole-cell variation of the patch voltage clamp technique was used. Results with each cell line were nearly identical. Two types of Ca channels were found in each cell line that are similar to the L-type and T-type Ca channels found in excitable cells. Nimodipine block of the L-type Ca channels in both cell lines is more potent than in previously studied tissues. The kinetics of nimodipine block are accounted for by a model that postulates 1:1 drug binding to open Ca channels with an apparent dissociation constant (KO) of 16-45 pM. In A7r5 cells, the rate of onset of nimodipine block increases with the test potential, in quantitative agreement with the model of open channel block. The apparent association rate (f) is 1.4 x 10(9) M-1 s-1; the dissociation rate (b) is about 0.024 s-1. In anterior pituitary cells (GH4C1 cells), KO is 30 times larger; b is only twice as fast, but f is 15 times slower. The comparative kinetic analysis indicates that the high-affinity binding site for nimodipine is similar in both GH4C1 and A7r5 cells, but nimodipine diffuses much faster or has a larger partition coefficient into the plasmalemma of A7r5 cells than for GH4C1 cells. Unusually high-affinity binding was not observed in earlier 45Ca flux studies with A10 and A7r5 cells. The model of open channel block accounts for the discrepancy; only a small fraction of the Ca channels are in the high affinity open state under the conditions used in 45Ca flux studies, so an effective binding constant is measured that is much greater than the dissociation constant for high-affinity binding.
Article: Cycling of Ca 2+ across the Plasma Membrane as a Mechanism for Generating a Ca 2+ Signal for Cell Activation
Article: Ca channels in adrenal glomerulosa cells: K+ and angiotensin II increase T-type Ca channel current. Proc Natl Acad Sci USA[Show abstract] [Hide abstract]
ABSTRACT: Ca channel currents were studied in freshly dispersed bovine adrenal glomerulosa cells to better understand the control of aldosterone secretion by extracellular K concentration (Ko) and angiotensin II (AII). The whole-cell variation of the patch voltage clamp technique was used. Two types of Ca channels were found. One type is similar to the "T-type" Ca channels found in many excitable cells. These channels deactivate slowly (tau approximately equal to 7 ms at -75 mV) and inactivate rapidly during strong depolarizations. The second channel type activates and inactivates at more positive potentials than the T-type Ca channels and deactivates rapidly. These channels are similar to the "L-type" Ca channels found in muscle and nerve. Our studies provide three reasons for concluding that T-type Ca channels have an important role in mediating stimulus-secretion coupling in response to high K+ or AII: (i) aldosterone secretion and steady-state current through T-type Ca channels are biphasic functions of Ko and both increase in parallel for Ko = 2-10 mM; (ii) nitrendipine blocks the T-type Ca channels and the stimulation of aldosterone secretion by high K+ or AII with similar potency; (iii) AII increases Ca entry through the T-type Ca channels.
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ABSTRACT: 1. Ca channels were studied in the GH4C1 clonal cell line derived from rat anterior pituitary cells. The whole-cell variation of the patch-electrode voltage-clamp technique was used. 2. Two types of Ca channels were found. One type ('slowly inactivating' channels) is insensitive to changes in holding potential, does not inactivate during test pulses lasting several seconds, and deactivates very quickly upon repolarization. For holding potentials less than -40 mV, a second type of Ca channel is available for opening. This population ('transient' channels) differs from the first type in that it activates at more negative potentials, inactivates rapidly with either Ca or Ba as the charge carrier, deactivates about 10 times more slowly upon repolarization, and is less selective for Ba over Cs. 3. Nimodipine preferentially blocks the slowly inactivating channels. Block of these channels is time- and voltage-dependent, such that block is maximized by long depolarizations. 4. A comparison of the voltage dependence of steady-state nimodipine block with the voltage dependence of channel activation indicates that channel block is directly proportional to the number of open channels. The results are accounted for by a model that postulates 1:1 high-affinity drug binding to open Ca channels. The apparent dissociation constant for binding to open channels is 517 pM. Similar binding constants were previously reported for the inhibition of high-K-induced hormone secretion and high-affinity ligand binding of [3H]nimodipine to isolated plasma membranes. 5. The rate of onset of nimodipine block increases with the test potential, in quantitative agreement with the model of open-channel block. The apparent association rate is about 9.6 X 10(7) M-1 s-1; the dissociation rate is about 0.050 s-1. At therapeutic concentrations (less than 10 nM) nimodipine block takes many seconds to reach equilibrium. 6. Nimodipine should have little effect on stimulus-secretion coupling in healthy pituitary cells in vivo because: (a) the drug binds very weakly to the transient channels that are open at normal resting potentials, and (b) negligible high-affinity binding occurs during spontaneous activity because the onset of block is very slow.
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Yale University
New Haven, Connecticut, United States
- • School of Medicine
- • Department of Internal Medicine
Yale-New Haven Hospital
New Haven, Connecticut, United States
- Department of Pathology


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Posts tagged business strategy
The most important question in social media marketing
Jul 23rd
Why? Because grandma always told me to deal with what is, not what we wish for. We have to be realists. Your best efforts to achieve accurate financial measurement may be constrained by technology, budget and resources. So, if you can't get there in the near-term, what DO you measure? That's why we'll now turn the discussion to non-financial indicators (NFI's) and the critical importance of selecting the correct measurement strategy for your social media marketing efforts.
There are hundreds of potential NFI's but there is only one question you need to know to pick the right one: What behavior am I trying to drive?
So you can see how powerful and critically important choosing the correct metric can be. And if you do, a magical thing will happen — Your marketing activities will begin to conform to that goal. The manner and level of engagement will rise to meet the need of pushing that metric higher and higher. If you choose wisely, the appropriate NFI will make your strategy EVOLVE!
What behavior are YOU trying to drive and how are your metrics supporting it? Sharing your ideas would help our community.
The next article in this series will examine specific options as you try to answer this most important question in marketing measurement.
This is Part Five of a series examining social media marketing measurement.
Part 2: Social media ROI shock treatment
Part 3: Irresponsible social media measurement research
Part 4: Social media impact on brand equity
Part 5: The most important question to ask in social media marketing
Part 6: A double standard for social media marketing?
Part 7: Yes, it IS about the money!
Part 8: Creating a measurement plan
Part 9: Measurement is like a bartender
Looking into the future of B2B online marketing
Jul 17th
Part 2: Essential B2B social media start-up strategies
Part 3: Developing a social media strategy when the rules aren't clear
Part 4: Social media time shock strategies
Well thank you, that's very flattering. I may be biased toward the present, but I think the most interesting online marketing development is a trend we're starting to see among the largest brands and agencies, both B2C and B2B – the re-integration of marketing channels.
We currently live in a world where B2B marketers largely trade off their budget between online marketing channels, or between online and offline channels — an ebb and flow we have seen in other historical contexts. Choices are made based on the individual ROI of each channel, historic or competitive precedent (e.g., "we've always run print ads in that publication, so we'll continue to do so"), or some combination of the two. The strategy/budget discussion largely occurs around which channel performs best, rather than how multiple channels work TOGETHER to deliver results. This occurs because 1) the online channels are developing quickly, making it hard to keep up with changes, even with a staff dedicated to a single channel, and 2) solid cross-channel metrics are so hard to come by for the vast majority of B2B marketers.
This "either-or" approach to marketing channels makes little sense in B2C and even less sense in B2B where most purchases involve multiple decision-makers and longer sales cycles. Think paid search marketing on one of the "big three" general search engines performs vastly better than banner advertising? Research suggests they serve different roles in the buying process: general search engines getting undue credit for being the major online portals from which people navigate just prior to purchase (e.g., 71% of paid search clicks are navigational) and banner ads exposure – simple exposure, not a click – driving a hidden 22% increase in search marketing conversion rate.
Thankfully, online marketing tools and techniques are catching up and enabling the discussion B2B marketers should be having – how different channels work together to deliver results, and what the optimal channel mix should be, based on these interactions and business goals.
This evolution – the re-integration of marketing channels as we remove technology barriers – is critically important for improving overall B2B marketing efficiency and should lead to a number of fascinating, useful insights in the coming years. Change is never easy, but shedding our "either-or" mentality for a more informed, integrated approach is a change worth making.
Social media time shock strategies
Jul 16th
Part 2: Essential B2B social media start-up strategies
Part 3: Developing a social media strategy when the rules aren't clear
One of the things most people learn is the tremendous amount of time it takes to effectively manage a social media campaign. How are you personally managing the time shock on top of your other traditional marketing duties?
Just like SEO, social media has a reputation as being "free" but both require a significant, ongoing time commitment to deliver a tangible impact on the business. The short answer to your question is that it is possible to manage the social media time commitment through a combination of pre-launch research, clear focus on goals and active project prioritization.
We researched the current state of B2B social media before we launched our blogs and Twitter accounts, and the time commitment issue came through loud and clear – the B2B social media success stories involved dedicated, consistent focus on initiatives over time, and the complaints about social media not working typically involved one shot campaigns which didn't work as intended or consumed time/resources far beyond their value.
After launching our social media initiative, clear focus on goals and active project prioritization kept the time commitment manageable (with an emphasis on the "manageable" part – there are still times where the team and I have no choice but to power through an unforeseen time sink).
Business Twitter initiative in trouble? Here's how to get it back on track!
Jul 16th
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Saturday, February 13, 2016
In "Life of a King," Cuba Gooding Jr. plays Eugene Brown, a man who is trying to start anew after 17 years in prison. After struggling to find a job, he lies about his background to land a janitor's position at a high school in his old neighborhood. There he converts a detention room of teenagers into chess players. The main plot — an inspiring teacher instills a group of bad kids with the values of teamwork, self-respect and strategy — is so clichéd that much of the movie is likely to feel like a flashback to previously seen films. The scenes of Eugene's confrontation with a neighborhood drug dealer are also overly familiar. Yet Mr. Gooding's performance and his complex charisma are fascinating to watch throughout. — Miriam Bale