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Dear Angie: How important is it to repair plaster before repainting? Our ceilings have peeling paint that we're pretty sure was caused by past water damage. Since the water problem is no longer an issue, can we simply repaint the ceilings or should we first repair any underlying plaster damage? – Sara S., Elgin, Illinois
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For larger projects, especially those that may involve more than three different service providers, a general contractor to oversee your project may be required.
Just as consumers don't like it when they call for help and don't get a return call, companies don't like it when they invest a lot of time to provide an estimate and never hear that their bid hasn't been accepted.
Don't tackle a DIY home repair without asking yourself these three questions.
Angie's Answers
I've used wall liner (it applies like wallpaper only thicker) to cover a multitude of "wall sins" over the years. In my opinion it's the greatest thing since sliced bread. It doesn't look cheap or tacky, it's inexpensive, non-labor intensive and not messy to install.
I used it for the first time about 15 years ago to cover a faux brick tile on my lower kitchen walls that couldn't be removed. It was either tear the wall down or take a chance on $40 worth of wall liner. It did the job beautifully and lasted. Since then I've used it to cover paneling, a badly gouged wall after a kitchen remodel and a wall that looked like a pegboard after floor to ceiling shelving was removed.
Friends and family (and realtors!) have been amazed by the transformation after applying this simple inexpensive product.
Remember, you not only have to remove the popcorn texture, but also redo the ceiling in some other texture.
Price will depend on several factors:
1) how much the contractor you choose hates removing popcorn or textured ceilings - some charge $1 or so/SF extra just because they hate it. There are even some who bid total drywall replacement cheaper than removing the popcorn, so you have to first find contractors who are happy to do that work, or your prices will be out of the realistic range
2) if the popcorn predates about 1990, then it could likely have asbestos in it, which doubles or triples the price, and in many cases uncapsulating it with a spray coating and then removing the drywall entirely is actually cheaper than all the protective measures necessary if it is scraped off.
3) whether the popcorn is primarily gypsum and vermiculite (comes off REAL easy) or was the plaster of paris variety, which takes a fair amount of soaking to soften it enough to scrape off
4) what type of finish you are replacing it with - if a textured ceiling, slapcoat, knockdown finish or paneling, not real problem. If you want to go with a perfectly smooth ceiling (generally a bad idea as any variations in the drywall on a ceiling surface really shows up dramatically), then it will demand a lot of care in preparing the scraped surface, and a complete surface drywall compound skim coat to smooth out the scrapes and gouges from the removal process.
5) what underlying conditions are - if there is a lot of furniture to move around (should go to adjacent rooms) or cover and work around, high-quality rug or hardwood floor to super-protect or such, will drive cost up.
I have seen costs run from as low as $0.60/SF to $1.25/SF (for removal only). Generally, remove and recoat with a surface texture of some kind (anything but smooth) and paint will run you about $2.50-3.50/SF.
Now the bad news - if asbestos containing, can run from $5-10/SF. Many homeowners in that situation go the other legal route - have it encapsulated with an asbestos-rated sealant by an asbestos contractor, then paint it and leave it for the next homeowner to decide what to do about it. Some contractors encapsulate it and then put a 1/4" thick drywall layer over it - this usually looks like a disaster unless it has a VERY rough textured finish on it, because putting drywall sheet over a rough surface like popcorn invariably means a wavy surface commonly looks like a gently rolling ocean surface.
Plaster reviews in Chattanooga
The results are stunning. The variance ...MoreRead more of this review plaster finish he created adds elegance, class, and charm to the space, and it's exactly what I envisioned for the room. I wish there was a category of A+ in this review because the quality of his work is superb.
He's a true craftsman, and I would recommend him to anyone who wants the quality and class.
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Sink or swim pools and patios
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The Flying Dutchman
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We want to put dark grout on the floor between dark porcelain tile (brown).
Everyone says that dark fades with time, so what can we do to keep it from fading?
Should we use an epoxy grout or add an additive to the grout before we use it.
Don't want to have to seal it every year. Thank you

subset: commoncrawl


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Description and Details
The true beauty of autumn colors is captured on this warm, orange fade wedding invitation featuring falling leaves embossed in white foil. Your wording is printed in your choice of colors and lettering styles. Invitation includes inner and outer envelopes. This invitation features thermography printing, an affordable printing process that results in raised lettering.
- Size: 4" x 9 1/4"


text: The establishment is the perfect base for business travellers and holiday makers alike, offering a wide range of services and facilities. The establishment features various services and facilities for a comfortable and relaxing stay, including internet access and wireless internet access. All accommodation units feature a kitchen and a bathroom. Guests will also find a balcony in most accommodation units. The accommodation units each feature a double bed. In addition, a fridge, a microwave and a dishwasher are available. Each accommodation unit offers internet access and a DVD player. Copyright GIATA 2004 - 2016.


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Lucy's Book Mark
Animal Adoption
50 Children
March LibraryReads List
March LibraryReads list came out and I missed posting it. Dreadful me! These are the tops according to librarians throughout the U.S. I've read two of them, "Divorce Papers" and "Circle of Wives" and totally agree with my fellow librarians.


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Welcome to the Library, where you'll find a selection of industry resources including eBooks, Whitepapers, Webinars, Survey Reports, Research Reports and more.
If you are interested in submitting items to the Library, please contact our advertising team
The Library is currently filtered to only show Ebooks. You can remove this filter by returning to the Library.
Roadmap to Achieve Successful EHR Adoption
Learn the tips, techniques, and strategies needed to drive EHR adoption, reduce user error, and achieve compliance by downloading the Roadmap to Achieve Successful EHR Adoption. If you're struggling with onboarding, training new employees, or sustaining use of your EHR, this free eBook can help.
Best Practices for Securing Your Mobile Network
No network is 100 percent secure from data breaches. Expanding mobile networks and the increasing number and type of handheld devices means it's not a question of "if," but "when." But health IT leaders know that to best serve patients and providers, they must balance security and the demand for quick, convenient access to patient information and other data. Download the ebook now!
eBrief | Cybersecurity in Healthcare: A Time to Act
Discover the essential steps healthcare providers and health insurers need to take to secure valuable patient information and mitigate risk of criminal hacking attempts. Download this eBrief today!
How to Be Successful in the Healthcare Revolution
New government and payer incentives are driving patient data generation and collection. This eBook discusses why healthcare IT vendors will drive the revolution in patient health and hospital operations, examples of cutting-edge devices for patients and providers and more! Download today!
Hospital Disaster Recovery
In this eBook, hospital leaders with first-hand experience--from a plane crash to a severe weather event--explain how to prepare for, respond to and recover from a disaster. Download today!


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7 comments
Faith in MindAttaining the Way is not difficult, Just avoid picking and choosing. If you have neither aversion nor desire, You'll thoroughly understand. A hair's breadth difference Is the gap between heaven and earth. If you want it to come forth Let there be no positive and negative. For such comparisons Are a sickness of the mind. More »
How Not to MindThe following is inspired by the classic Chan poem "Xinxin Ming" (lit., "Trust-Mind Inscription") by Jianzhi Sengcan (d. 606). More »
Consider the Source: Ordinary Mind ZenBecause the fundamental nature of consciousness, of mind itself, is without characteristics, Zen Buddhism teaches signlessness. Ordinary activity, reflected in the lives of monks or villagers, fully embodies this signless teaching about mind. This is the "Treasury of the True Dharma Eye, whose true sign is signlessness, the sublime Dharma gate," as taught in Zen's founding legend by the Buddha. The "sublime gate" of signlessness is not at all empty of meaning. Traditionally, taking Zen's signless path leads first to perceiving, then seeing through, reincarnation, the "wheel of birth and death." What is quite profound is then inextricable from what is entirely ordinary. It is passages about the "ordinary," where the difference between sacred and mundane is forgotten, that Zen literature takes on its peculiar flavor. More »
Consider the Source: Origins of the Wild Goose PagodaTourist groups that visit the Terra Cotta Warriors inevitably visit Xian's other famous landmark, the Wild Goose Pagoda, an icon central to the development of Chinese Buddhism. In this post I will explore why the Wild Goose Pagoda is such an object of pride for the city of Xian, and its role in Chinese Buddhism's development. For centuries, Buddhism entered China along the Silk Road, the legendary trade route that stretched from ancient Rome to Xian. This trade route passed directly through the region where Mahayana Buddhism developed, serving to convey Mahayana teachings to China. More »
Consider the Source: Are Baizhang's Famous "Pure Rules" a Fake?The ancient Chinese Zen master Baizhang established "pure rules" for the regulation of his monastery on Great Hero Mountain in China. The rules have served as the basis for monastic organization and practice for centuries, and their influence has extended to Zen monasteries throughout China and beyond. The Chinese Zen tradition acknowledges that The Pure Rules is a reconstruction written about 400 years after Baizhang lived. The original text of Baizhang's regulations was lost in the chaos of war as Chinese dynasties rose and fell in the centuries following his death. Many take on faith that the current version of Baizhang's rules was reconstructed to accurately reflect the original text based on available evidence. But this view may be entirely mistaken. More »
Consider the Source: Why did the Ancient Zen Masters Seldom Mention Emptiness?Early Chinese Zen masters seldom spoke about ideas like emptiness. Early writings also lack discussions about sutras, including texts like The Diamond Sutra, which is strongly linked to the Zen tradition. The Heart Sutra is hardly mentioned, and the bodhisattva ideal also gets very little ink in early records. Often, when such ideas and texts are mentioned by the old masters they are referred to with a dismissive, even derisive, tone. More »


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The Mary McLeod Bethune Council House National Historic Site provides a wide variety of materials and activities that can be reinforced in the classroom. Visit our Parks as Classrooms page to learn more.
The Bethune Council House can also provide Park Rangers to conduct off-site programs at schools in the Washington, D.C. area. Contact us by phone at 202-673-2402 to learn about availability.
2013 Teacher Ranger Teacher Program
Melissa Green, a Fairfax County Public Schools Teacher, came to the Mary McLeod Bethune Council House National Historic Site in 2013 through the National Park Service Teacher Ranger Teacher program. While she was with us, she developed two of the lesson plans we now have available to the public: "The Mary McLeod Bethune Virtual Experience" and "Negro League Baseball and its Connection to Mrs. Mary McLeod Bethune."
Ms. Green made a video talking about Mary McLeod Bethune and her experiences as a Teacher Ranger Teacher.
Learn more about the National Park Service Teacher Ranger Teacher program.


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Seven HK flights affected by crash
PUBLISHED : Tuesday, 24 March, 2009, 12:00am
UPDATED : Tuesday, 24 March, 2009, 12:00am
Joshua But
Most Popular
The Hong Kong Airport Authority said the plane crash at Narita airport had affected seven flights between Hong Kong and Tokyo yesterday, with four cancelled.
Japan Airlines and All Nippon Airways cancelled JL832 and NH910 that were scheduled to leave Hong Kong, and two incoming flights, JL731 and NH909.
Another flight, JL736, destined for Tokyo was rerouted to Nagoya yesterday morning while two other morning flights were delayed for about an hour.
Travel Industry Council executive director Joseph Tung Yao-chung said the crash would have a slight impact on Hong Kong tours in Japan - a popular destination for Hongkongers.
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The rooms are clean and the WI FI worked well. However, the toilets, sinks and the shower needs a real good face lift. The rusted sinks looks filthy and turns you away. The rooms gets a 4 star while the bathrooms facility deserves 1 star.
If you want Wi-Fi then move M if you want a good place to rest then it's good. It's not a 5 star bit the rooms aren't filthy. I'm a person who won't stay in a dump and worry of smells and bed bugs and get grossed out quickly. This place is worth the inexpensive cost.
While the room that I was given was in good quality; the wifi never worked in the room and the high speed Internet cable in my room was broken.
The breakfast was alright at best. If you got there within 30 mins of it being severed.
This property is dirty, not managed by trained hospitality people, and is in complete need of repairs inside and out.
I travel a lot for my business in the USA and Canada and have never experienced such filth.
Our trip to Kingsville, Texas was for family reasons and someone else also not familiar with this property booked our room.
We stayed at Rodeway Inn Kingsville in October 2010 and had a good stay. I was older but felt it was a good value for the price. However this trip (April 2012) was very different. The first thing we noticed when we walked through the doorway was as strong musty odor. Our room looked like it had not been cleaned...
It is probably not a greatest place to stay but can't compalin when you are there. You get good care and helpful people. Always smiling and always happy and good atmosphere. I bet they are very well paid and work under good management...........
My wife and I enjoyed our stay. It was a great value.
Motel has a convenient store attached to lobby, also a club and exercise room.
Beds were comfortable, clean. Fair breakfast in the morning
It was absolutely awful. The only good thing about it was that there was a bar attached to it because one had to be drunk in order to sleep there. I know it was cheap, but the room was dirty and absolutely gross. I would never stay there again
Wife, myself, son/fiancee were in kingsville for my father in-law's funeral. We had first booked the Super 8 but there were odor(mothballs), rat issues and we got a refund and moved to the Rodeway Inn. Wife and I had stayed there 3-4 yrs ago but I forgot how hotel looked. We spoke to front desk and booked 3 rooms for...


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Having a car on campus won't be necessary only to get to campus but to get to your class you can walk. Parking garages are expensive when they're closer and if you park anywhere outside of that you have to be very careful because enforcement is constantly going around and basically is the only thing police check for during they day.
Drug Safety:
Have not heard too much of drug use on this campus
Local Area:
everything is in close proximity
Party Scene:
You can nearly see the bar scene from campus
They have plenty of study areas just very few students take advantage of them. Professors are the best because they provide real live stories from there perspective and knowledge of field.
There are so many opportunities that the school provides to students as of work and internships.
Guys & Girls:
They can dress a bit inappropriate with far too much skin showing
Party Scene:
It's great because transportation is easy as taking the light rail to just walking a distance to where you need to go.
Arizona has the best whether and summer time is great when the school provides a roof pool for students only. You can do so much in here.
Being that it is Arizona, the weather tends to be extreme. It is either extremely hot or extremely cold, making it difficult to tread across campus from class to class.
Campus Housing:
It's the best when you look at it. It is a bit expensive but if you look at the quality it's worth it because you get your own bathroom with shower and sink and am pretty sure most colleges have to share showers with everyone. The housing process is strict so you have to make your final decision and when you submit it it's hard to get out of it because you have to follow through the time period unless otherwise. You got to go through a process to change your on campus status.
Campus strictness is the best because they have security and you have to go through them before you get in so in a way it's good because all students from where ever they say there from won't have access unless they have a valid I.D. and someone to sign them in. There has been an incident where a couple of students where trying to get in saying they wanted me to get them in and made up the dumbest story which I know they were up to something.
Drug Safety:
There are rules on drugs but students still do it and if they don't get caught then for them it's okay to do it again but there has been a couple of cases where students do get caught only do to alcohol poison or rumors which isn't the best way to find out. The reason being is it could be all to late finding out afterwards tragic things happen.
Health & Safety:
When it comes to safety, ASU downtown location has the best police and are on top of things even though they are on it when it comes to parking tickets. Since there is homeless around all buildings require you to scan your school I.D. and without it you can't get in the building.
Campus Quality:
The campus is about new than the other 3 locations. Facilities, are descent as well as campus life is good. It is a good experience to have when living on campus. There are plenty of opportunities at this school that are easy access for students and if you never hear of them then your not really involved with school. The school informs students of events and opportunities and do their best to get the word out there and encourage students to get involved and show up to these events.
Campus Quality:
I would say it's okay because the space in the dorms are descent they are connected to a floor which have laundry on each floor, plus snack machines, to a printer and two computers available on every other floor to a t.v on one floor and the other a quiet place so basically you can choose where to hang out. There are also traditions like homecomings which are fun to go to and lots of night events to floor events as well.
Guys & Girls:
The Downtown Phoenix campus is a lot smaller than Tempe so you're likely to encounter mainly students of a few majors, like journalism students, nursing, or exercise and wellness, but there is still a variety. Difficult to classify into groups.
Health & Safety:
The health center is convenient on campus. Pretty safe as long as you don't walk far away from campus alone late at night.
Campus Food:
The food at Taylor Place (DTP campus) is good on some days and not too great on other days. The meals also become redundant after a few days.
Off-Campus Dining:
There are quite a few dining options in the Downtown Phoenix campus, but many of them are pricey restaurants for a student budget and a few blocks away from the residence hall. The Arizona Center is near the residence hall and has decent options, like corner bakery and a Mexican food restaurant.
Health & Safety:
campus security needs to be more visible doing things other than parking tickets
Campus Housing:
They have recently made a push to get more dorms and nearby housing so it is getting a lot better
I like my major as I want to help the environment and people
Overall Experience:
It's convenient and it works for me
I am straight but I have a lot of friends in the LGBT community
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Arizona State is like no other university in the country. With a large, vibrant, and exciting student body that truly makes the campus unique, there is no arguing that ASU is by any means a boring place to be for the next four years of your life. As soon as you step onto ASU's campus, you will feel the immense amount of positive and exciting energy that gives you sense of belonging. Even though there are so many students around campus, you will be sure to find a niche to call your own. College is the time to find yourself and truly learn who you are as you prepare for the real world. ASU provides the perfect environment to challenge you to make "adult" decisions, and you won't always, but by the end of it all, you will mature into a dedicated individual!
Even though students will struggle with all-nighters, sports practice, parking tickets, and trying to recover from a great night, many of them couldn't ask for anything else. There will be times that you are drowning in homework and studying, but by the end of it all, you will look back and laugh. Your peers help you get through the tough times and make those social outings even more fun. ASU knows how to party hard, but when it comes to crunch time, we pull it off well. The kids here know how to have a great time, the nightlife and social settings are extremely fun, the academics are quite challenging—especially when you apply yourself and take it seriously—but most importantly, students will leave prepared for post-graduation and taking on the world. ASU is a fantastic place to meet new people and a great way to experience life in the great southwest. But don't take my word for it—come on out and experience it for yourself!
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text: In the words of the Mad Hatter, "There is a place. Like no place on Earth. A land full of wonder, mystery, and danger! Some say to survive it: You need to be as mad as a hatter." Far Cry 3 drops you in a jungle filled with just that; a world of maddening adventure at your fingertips, but can you fully grasp what is being presented to you? 4.5/5


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January 11, 2012
The former Draper school building, seen here in June 2011, is now closer to becoming repurposed for housing for disabled veterans.
Stories this photo appears in:
Housing for disabled vets progresses
County commits to sell former school following foreclosure
After two and a half years of efforts in Rotterdam to open the first Disabled American Veterans apartment complex in the country, the proposal is closer to becoming a reality.
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note all the stored aircraft in the background
Taxiing to runway Düsseldorf, Germany
As from this date, Lufthansa will service CCS with a daily A340-600 all year round. Dedicated to Michelangelo Minervini, Robinson Joa and Orlando Suarez.
Dusseldorf has it's share of interesting airlines. Mahan Air from Iran is one of them. Airbus A310-300 F-OJHI just arrived.


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Current Drug Targets - Cardiovascular & Hematological Disorders
Journal description
Current Drug Targets - Cardiovascular & Hematological Disorders aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in cardiovascular and hematological disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal will contain a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in cardiovascular and hematological disorders. As the discovery, identification, characterization and validation of novel human drug targets for cardiovascular and hematological drug discovery continues to grow; this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development. Discontinued. Continued as Cardiovascular & Haematological Disorders - Drug Targets (1871-529X).
Current impact factor: 0.00
Impact Factor Rankings
Additional details
|5-year impact
|Cited half-life
|Immediacy index
|Article influence
|Current Drug Targets - Cardiovascular & Hematological Disorders website
|Other titles
|Current drug targets., Cardiovascular & hematological disorders, Cardiovascular & haematological disorders, Cardiovascular and hematological disorders, Cardiovascular and haematological disorders, Current drug targets., Current drug targets., Current drug targets
|Material type
|Document, Periodical, Internet resource
|Document type
|Internet Resource, Computer File, Journal / Magazine / Newspaper
Publisher details
- Pre-print
- Author can archive a pre-print version
- Post-print
- Author cannot archive a post-print version
- Restrictions
- 12 months embargo
- Conditions
- Author's pre-print on author's personal website, institutional repository and open access repository
- Author's post-print on author's personal website, institutional repository, open access repository, PubMed Central and arXiv
- Non-Commercial
- Published source must be acknowledged
- Must link to journal homepage with DOI
- Publisher's version/PDF cannot be used
- Classificationyellow
Publications in this journal
Article: Accuracy of physical examination versus ultrasound in the detection of hepatosplenomegaly at diagnosis of pediatric leukemia
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ABSTRACT: The Liver X Receptors, LXRalpha and LXRbeta are members of the nuclear hormone receptor superfamily which have recently been implicated as novel pharmacological targets for the treatment of cardiovascular diseases. The identification of natural and synthetic ligands for LXRs and the generation of LXR-deficient mice have been crucial for our understanding of the function of these receptors and for the identification of LXR-regulated target genes, particularly with respect to the role of LXRs in regulating cholesterol homeostasis. Synthetic LXRalpha/beta agonists induce cholesterol efflux and reverse cholesterol transport, improve glucose metabolism, inhibit macrophage-derived inflammation, and suppress the proliferation of vascular smooth muscle cells. By regulating the expression of multiple genes involved in these pathways, LXR agonists prevent the development and progression of atherosclerosis and inhibit neointima formation following angioplasty of the arterial wall. In this review, we will summarize the important roles of LXR in metabolism and vascular biology and discuss its implications as potential molecular drug target for the treatment of cardiovascular diseases.
Article: Increasing High-Density Lipoprotein Cholesterol Through Cholesteryl Ester Transfer Protein Inhibition: A Next Step in the Fight Against Cardiovascular Disease?[Show abstract] [Hide abstract]
ABSTRACT: Over the past decades, lowering of LDL-cholesterol (LDL-c) levels has been established as the foundation for preventing atherosclerotic disease. It is, however, widely accepted that additional risk reduction has to come from modifying other risk factors than LDL-c. In this context, increasing HDL-cholesterol (HDL-c) levels by pharmacological inhibition of the cholesteryl ester transfer protein (CETP) is currently under intense investigation. Two small-molecule compounds, JTT-705 and Torcetrapib, have been shown to effectively increase HDL-c levels in humans, without inducing clinically significant side effects when used as monotherapy or combined with statins. Whether this approach will translate into a reduction in risk of atherosclerotic disease has not yet been established. Data from studies focusing on genetic CETP deficiency as well as those studying the relationship between CETP plasma levels and risk of atherosclerosis do not provide clear answers. Several long-term clinical studies addressing this crucial issue have recently been initiated, results of which will follow within the next few years. This review focuses on CETP, its role in human lipid metabolism and its relation to atherosclerotic disease. Furthermore, it summarizes the currently available data regarding pharmacological CETP inhibition. Finally, it will highlight a number of issues basic to the considerations of whether CETP inhibition will fulfill its promises.
Article: Emerging pharmacological strategies for the prevention of atherosclerotic disease progression.
Article: Lipoprotein-associated Phospholipase A2: A Potential Therapeutic Target for Atherosclerosis[Show abstract] [Hide abstract]
ABSTRACT: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an enzyme that is produced by inflammatory cells, is bound to circulating LDL, and is involved in hydrolyzing polar phospholipids, including those found in oxidized low-density lipoproteins. To date, the biological role of Lp-PLA(2) in atherogenesis has been controversial, with initial reports purporting an atheroprotective effect attributable to the degradation of platelet activating factor and similar molecules. However, more recent studies suggest a proatherogenic role for this enzyme, which is attributed to Lp-PLA(2)-mediated hydrolysis of oxidatively modified low-density lipoproteins that results in the accumulation of proinflammatory products. The liberation of lysophosphatidylcholine and oxidized nonesterified fatty acids from oxidized phospholipids by the action of Lp-PLA(2) results in diverse inflammatory effects on various cell types involved in atherogenesis. This concept is further supported by a number of recently published epidemiology studies suggesting that plasma levels of the enzyme predict future cardiovascular events independent of conventional risk factors. The development of selective inhibitors of Lp-PLA(2) that inhibit enzyme activity in the circulation as well as within human atherosclerotic lesions opens the possibility of therapeutic manipulation of vascular inflammatory processes to reduce residual cardiovascular events in high risk individuals who continue to suffer fatal and nonfatal events despite the current standard of care.
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ABSTRACT: The peroxisome proliferator-activated receptors (PPARs) alpha, beta/delta and gamma are ligand-activated transcription factors belonging to the nuclear receptor superfamily. PPARs heterodimerize with the retinoid X receptor (RXR) and modulate the function of many target genes. They were originally described as regulators of various metabolic, pathways, but have been recently found to also exert modulating actions in the vascular wall. PPARalpha is activated by endogenous ligands, such as polyunsaturated fatty acids and by synthetic agonists such as the fibrates. PPARalpha is expressed mainly in the liver, kidney and skeletal muscle and is involved in fatty acid oxidation. However, it is also expressed in vascular cells such as the endothelial cells, vascular smooth muscle cells and macrophages, where it exerts anti-inflammatory and antioxidant effects. Since atherosclerosis is both a chronic inflammatory and a lipid disorder and since PPARalpha is expressed in vascular cells and regulates the expression of genes involved in lipid metabolism and inflammation, PPARalpha activators may constitute useful agents for the prevention of atherosclerosis, beyond their effects on lipid metabolism. This review will focus on the functions of PPARalpha on lipid metabolism, on vascular inflammation and its relationship to atherosclerosis. Furthermore, the currently available preclinical and clinical data on PPARalpha activators as well as their future perspectives will be discussed.
Article: ApoA-I Milano/phospholipid Complexes Emerging Pharmacological Strategies and Medications for the Prevention of Atherosclerotic Plaque Progression[Show abstract] [Hide abstract]
ABSTRACT: Epidemiologic and experimental observations suggest high density lipoprotein (HDL) has a protective effect against atherothrombotic vascular disease. These findings have stimulated considerable interest to promote HDL as a potential therapeutic strategy. Several exciting therapeutic strategies have recently emerged and currently are the focus of intense research interest. One approach is the direct administration of HDL or its components such as apolipoprotein A-I (apoA-I). Recently, much attention has focused on a naturally occurring variant of apoA-I, apoA-I(Milano) (apoA-IM) characterized by a cysteine for arginine substitution that is associated with low rates of vascular disease and significant longevity in its carriers, despite markedly reduced HDL and elevated triglyceride levels. The mutation alters the characteristics of the protein resulting in apoA-IM being functionally more effective than normal apoA-I. A number of animal and laboratory studies have demonstrated significant antiatherogenic, antiproliferative, antirestenotic, antiplatelet, antithrombotic, antiinflammatory, and antioxidant properties of apoA-IM. Furthermore, apoA-IM has been shown to promote reverse cholesterol transport, improve endothelial dysfunction and induce rapid mobilization of tissue cholesterol resulting in regression and alteration of plaque composition in animal models of atherosclerosis. Recently, a pilot clinical trial of recombinant apoA-IM demonstrated significant and rapid regression of atherosclerosis as measured by intravascular ultrasound in patients with acute coronary syndromes. These promising data provide the rationale for the development of reconstituted HDL utilizing recombinant apoA-IM as a potential therapeutic approach for atherothrombotic vascular disease in humans.
- [Show abstract] [Hide abstract]
ABSTRACT: The reduction of circulating atherogenic lipoproteins through lifestyle modification and pharmacologic intervention is an important therapeutic goal in patients at risk for acute cardiovascular events. A large number of clinical trials have demonstrated that the reduction of low-density lipoprotein cholesterol (LDL-C) is associated with significant decreases in the incidence of all cause mortality, stroke, fatal and nonfatal myocardial infarction, and the need for revascularization with coronary artery bypass grafting and percutaneous transluminal coronary angioplasty. Therapy with 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (i.e., statins) are the agents of choice for treating a variety of dyslipidemias, particularly when LDL-C levels are elevated. The statins are highly efficacious; however, not all patients are able to tolerate the higher doses of these medications due to adverse side-effects such as hepatoxicity and myotoxicity. Moreover, many patients cannot achieve their various lipoprotein targets at even the highest doses of these medications. Ezetimibe is a novel cholesterol absorption inhibitor that blocks the translocation of dietary and biliary cholesterol from the gastrointestinal lumen into the intracellular space of jejunal enterocytes. Ezetimibe undergoes enterohepatic recirculation with minimal systemic exposure and not does not adversely impact the pharmacokinetic profile of statins. Ezetimibe significantly reduces serum LDL-C. It is safe when used as monotherapy or when used in combination with statins. Ezetimibe is indicated in the management of hyperlipidemia, familial hypercholesterolemia, and sitosterolemia and significantly increases the percentage of patients able to reach their lipid-lowering goals.
Article: A Rationale for Combined Therapy with a Calcium Channel Blocker and a Statin: Evaluation of Basic and Clinical Evidence[Show abstract] [Hide abstract]
ABSTRACT: Calcium channel blockers and HMG-CoA reductase inhibitors are widely used for the management of hypertension and dyslipidemia, respectively. The use of these agents in the prevention and treatment of cardiovascular disease remains largely based on their actions in lowering blood pressure and lipids. Recent clinical trials, however, indicate that certain members of these two drug classes may slow progression of disease to an extent that cannot be solely attributed to risk factor reduction. The proposed mechanisms for such pleiotropic actions include enhancement of endothelial-dependent nitric oxide bioavailability, anti-inflammatory activity, and inhibition of oxidative stress. To understand the basis for such effects, along with potential synergies, we will review the basic and clinical evidence that indicate a broader opportunity for treatment and protection of cardiovascular events by atheroprotection with these agents beyond risk factor management.
Article: Endocannabinoid Receptor Antagonists and Other Emerging Pharmacological Strategies for Weight Reduction[Show abstract] [Hide abstract]
ABSTRACT: Overweight and obesity are recognised as significant risk factors for coronary heart disease (CHD). Weight reduction leads to reduction in associated CHD risk factors. The discovery that endocannabinoid system is involved in regulation of food intake and other reward behaviours has led to development of cannabinoid receptor antagonists. Recent studies with rimonabant, a cannabinoid type 1 receptor (CB(1)) antagonist, demonstrate clinically significant weight loss as well as reduction in metabolic syndromme burden in obese patients.
- [Show abstract] [Hide abstract]
ABSTRACT: Mature human atherosclerotic plaques are frequently characterized by a lipid-rich core covered by a fibrous cap composed of fibrillar collagens, elastin, proteoglycans and smooth muscle cells (SMC). Most sudden deaths due to acute myocardial infarction are caused by rupture of coronary atheroma, leading to a prothrombotic response followed by rapid occlusion of the artery. The accumulation of macrophage-derived foam cells in vulnerable shoulder regions of atherosclerotic plaques correlates with increased local release of matrix-degrading metalloproteinases (MMPs) and weak fibrous cap tissue. These findings suggest a potential role of macrophage-derived MMPs in the weakening and ultimate rupture of plaque structures. Consequently, several studies have focussed on the hypothesis that inhibiting MMP activity would reduce plaque volume and prevent plaque rupture and therefore would be useful in the treatment of atherosclerosis. However, current synthetic MMP inhibitors are not very specific and clinical results have so far been inconclusive. The development of selective inhibitors and focal gene transfer approaches may be better suited for the treatment of atherosclerosis.
Article: Non-invasive Atherosclerosis Imaging: Use to Assess Response to Novel or Combination Lipid Therapies[Show abstract] [Hide abstract]
ABSTRACT: Despite significant protection from cardiovascular events by HMG-CoA reductase inhibitors (statins), the extent of event reduction is incomplete and persistent lipid abnormalities remain prevalent. As such, the use of combination lipid modification regimens is a clinical reality. While we await large, randomized clinical outcomes trials assessing the benefits of combination or novel lipid management therapies, non-invasive imaging tests such as B-mode ultrasound to measure carotid intima-media thickness (CIMT), coronary computed tomography (CT) and cardiovascular magnetic resonance imaging (CMR) are increasingly being utilized to accurately assess the impact of lipid modifying therapies on atherosclerosis. Based on knowledge that atherosclerosis progression is a validated surrogate for increased cardiovascular risk, use of atherosclerosis imaging surrogates in studies allows for smaller sample sizes, shortens study duration, demonstrates clinically meaningful changes prior to clinical event and provides potentially useful pathophysiologic information. CIMT measurement is currently the most studied and validated non-invasive imaging study used to assess atherosclerosis longitudinally in response to lipid modification therapies. Quantification of coronary calcium using coronary CT has been utilized to study atherosclerosis longitudinally, however, calcium scoring to assess response to lipid modifying therapies is not recommended due to several limitations of this assessment of the atherosclerosis process. These include the fact that non-calcified atherosclerosis is not quantified, that the calcification process in atherosclerosis is diverse and that the effects of statins on tissue calcification are complex. Use of contrast coronary CT to image non-calcified coronary atherosclerosis is promising. Modern CMR imaging, aided by high reproducibility and image resolution, is rapidly advancing and early studies imaging non-coronary and coronary atherosclerosis are impressive.
Article: Preventing Atherosclerosis with Angiotensin-Converting Enzyme Inhibitors: Emphasis on Diabetic Atherosclerosis[Show abstract] [Hide abstract]
ABSTRACT: The incidence of diabetes is increasing at an alarming rate to the point where it is becoming an epidemic. An ageing population, sedentary lifestyle and an unhealthy diet are considered to have contributed toward this. What we must now consider is not only the burden of the disease but the complications that arise from diabetes, in particular kidney and heart disease. Foremost, more than half of the diabetic population will die from cardiovascular-related causes. Whilst diabetes is most often associated with hypertension, dyslipidaemia and obesity, these factors do not fully account for the increased burden of cardiovascular disease in people with diabetes. This strengthens the need for comprehensive studies investigating the underlying mechanisms mediating diabetic cardiovascular disease, and more specifically, diabetes-associated atherosclerosis. In addition to the recognised metabolic abnormalities associated with diabetes, upregulation of putative pathological pathways such as advanced glycation endproducts, renin-angiotensin system, oxidative stress and increased expression of growth factors and cytokines have been observed in the setting of diabetes. All of these have been shown to play a causal role in atherosclerotic plaque formation and thus may explain the increased risk of macrovascular complications in those patients with diabetes. In this review the effect of inhibiting the renin-angiotensin system with angiotensin converting enzyme inhibition and a comparison to angiotensin II receptor antagonism is discussed, with the results of clinical trails reflecting the more recently discovered, non-haemodynamic, proatherogenic actions of angiotensin II. The need for experimental models of diabetes-associated atherosclerosis will be covered, with particular emphasis given to the streptozotocin-diabetic apolipoprotein E knockout mouse. Finally, growth factors, including vascular endothelial growth factor and platelet-derived growth factor are discussed in detail.
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ABSTRACT: Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is an intracellular enzyme that catalyzes the formation of cholesterol esters from cholesterol and fatty acyl-coenzyme A. Animal experiments showed that ACAT inhibitors reduce plasma cholesterol levels by suppressing absorption of dietary cholesterol and by suppressing the assembly and secretion of apolipoprotein B-containing lipoproteins such as very low density lipoprotein in liver and chylomicron in intestine. Moreover, ACAT inhibitors were shown to prevent formation of macrophage-derived foam cells in the arterial walls. However, a recent double-blind, placebo-controlled, randomized trial of a potent ACAT inhibitor, avasimibe, failed to show significant beneficial effects on coronary atherosclerosis assessed by intravascular ultrasound. For clinical application of ACAT inhibitors, development of more potent compounds and improvements of the methods to evaluate their clinical efficacy are strongly needed.
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ABSTRACT: The last decade has seen a number of important advances in the use of animal models of atherosclerosis progression. Small animal models, particularly mouse knockouts and rabbit models, are finding increasing use. This review discusses those models of particular research utility, highlights their advantages and limitations, and specifically addresses methodologies and current developments, in what is a rapidly changing field.
Article: Editorial: Emerging Pharmacological Strategies for the Prevention of Atherosclerotic Disease Progression
- [Show abstract] [Hide abstract]
ABSTRACT: The peroxisome proliferator-activated receptors (PPARs) α, β/δ and γ are ligand-activated transcription factors belonging to the nuclear receptor superfamily. PPARs heterodimerize with the retinoid X receptor (RXR) and modulate the function of many target genes. They were originally described as regulators of various metabolic, pathways, but have been recently found to also exert modulating actions in the vascular wall. PPARα is activated by endogenous ligands, such as polyunsaturated fatty acids and by synthetic agonists such as the fibrates. PPARα is expressed mainly in the liver, kidney and skeletal muscle and is involved in fatty acid oxidation. However, it is also expressed in vascular cells such as the endothelial cells, vascular smooth muscle cells and macrophages, where it exerts anti-inflammatory and antioxidant effects. Since atherosclerosis is both a chronic inflammatory and a lipid disorder and since PPARα is expressed in vascular cells and regulates the expression of genes involved in lipid metabolism and inflammation, PPARα activators may constitute useful agents for the prevention of atherosclerosis, beyond their effects on lipid metabolism. This review will focus on the functions of PPARα on lipid metabolism, on vascular inflammation and its relationship to atherosclerosis. Furthermore, the currently available preclinical and clinical data on PPARα activators as well as their future perspectives will be discussed
Article: Drug Therapy in Brugada Syndrome[Show abstract] [Hide abstract]
ABSTRACT: Sudden cardiac death in healthy individuals with structurally normal hearts and a characteristic morphology of the QRS complex resembling a right bundle branch block with elevation of the ST segment in V1 to V3 is known as Brugada syndrome (BrS). Although placement of an implantable cardioverter-defibrillator is considered the only effective therapy for symptomatic patients, some authors have repeatedly reported a beneficial effect of quinidine and isoproterenol in patients with BrS. Also, isolated case reports on the usefulness of cilostazol, sotalol, and mexiletine have been described. The present article reviews the mechanisms by which these drugs may act and their role in the pharmacotherapy of BrS. Other possible agents, mainly I(2) blockers, are also reviewed.
- [Show abstract] [Hide abstract]
ABSTRACT: Atrial fibrillation (AF) is the most common cardiac arrhythmia seen in clinical practice. The understanding of the pathophysiology of AF has changed drastically during the last several decades. Recent observations have challenged the concept of the multiple circuit reentry model in favor of single focus or single circuit reentry models. Atrial electrical dysfunction provides a favorable substrate and transmembrane ionic currents are key determinants. Recent research is focusing increasingly on the atrial structural remodeling, which underlies the development of AF in different pathological conditions. This has led to concepts about how interfering with the substrate might prevent AF development and recurrence. Particular interest has been generated in the role of renin angiotensin system (RAS) blockade in reversing the electrical and structural remodeling of diseased atria. The mechanisms for the preventive effect of angiotensin converting enzyme inhibitors (ACEi) or angiotensin-II (AT-II) type 1 receptor blockers (ARB) in AF are probably complex. They may comprise general haemodynamic changes leading to lower intra-atrial pressure and wall-stress, or reduce in atrial fibrosis, connexin43 over-expression and conduction delay. The promising results of several clinical trials concerning RAS blockade may herald a whole new era of AF treatment, where AF is prevented and treated by modifying its substrate rather than fighting it electrically. This review centers on the pathophysiology of the structural and electrical remodeling in AF, the possible mechanisms by which RAS blockade may reverse electrical and structural remodeling of diseased atria and on the role of ACEi or ARB blockers in AF prevention and treatment that has already been postulated both experimentally and clinically.
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.


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About StumbleDNA StumbleDNA
This Tortoise Could Save a Life - Ft. Alan Rickman
The 32 Best Fantasy Books Of 2015
Tattoos Elegantly Combine Delicate Natural Subjects with...
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Making sure your site is mobile-friendly has become more important than ever before following Google's recent announcement: "Starting April 21, we will be expanding our use of mobile-friendliness as a ranking signal. This change will affect mobile searches in all languages … Continue reading →
One of the most powerful and underused ways to increase conversions of your products is to build video content around them. The most obvious advantage of video is its ability to engage your target audience and convince them of the … Continue reading →
Ecommerce websites rely on high conversion rates and a solid performance in organic search results. Below we have listed 10 things that will help strengthen both of these KPI's. Continue reading →
Mobile search has been hard to ignore in 2012 – take a look in any analytics profile and over the course of 2011 and 2012 you are likely to see a an increase in "mobile visits" Continue reading →
This week I was invited to speak at Search Love, a fantastic confernce run by Distilled. I did a session on the future of small business SEO. You can download it here Search Love Presentation There was also an amazing graphic … Continue reading →


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Icon by griffsnuffWatch
©2013-2016 griffsnuff
Man I wish I could do stuff like this! I've been wanting a new icon for a while now...
wow like all that little detail in that tiny space >O< im jellin
and like wow that design is such a cute one, its so simple but yet it looks really nice
and like wow that design is such a cute one, its so simple but yet it looks really nice
uhh yeah as it's so random, i wouldn't care having this random design ...
just kidding, great icon, love the sticker-ish shadows and the play with gradients! c;
so pretty!! *0*
This is so great! You're really good at fitting small details on small canvases, something I need to work on hehehe
So adorable and pretty~
you should make it free to use!
ommmmmmggg I wannnttt
That is so cute! You're amazing at fitting all that detail into such little space! Going to be tempted to do fan art of this one.
thatss so cute!


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So much for Men, Women And Children being a comeback for Jason Reitman. After a tepid reception at its world premiere in the Toronto International Film Festival, the drama that stars Jennifer Garner, Adam Sandler and Rosemarie DeWitt tanked hard at the box office this weekend.
As you might have guessed, a good number of the subplots featured in Jason Reitmans movie involve online pornography. What you might not have figured is how much time (and money) Reitman put into making the porn in his movie so realistic.
Warner Bros. has just bailed on plans to make The Ridiculous Six, a comedy Western that Sandler was set to headline. The timing of this decision has some suggesting that Sandler's deal to make four films for Netflix was the death nail in a long-troubled project.
Following word that Netflix was set to debut their first original movie in the form of a Crouching Tiger, Hidden Dragon followup, the streaming video service has announced that they're set to make four original feature films with Adam Sandler.
Michael Mann has revealed that Russell Crowe and Adam Sandler were originally lined-up to play the two lead roles in his 2004 classic, Collateral. Originally entitled, The Last Domino, the film went through many different variations before Jamie Foxx and Tom Cruise were finally cast in their celebrated roles.
Have you ever been tempted to look at someone else's phone? Who do they text? What pictures do they save? What are they hiding? This modern quandary plays at the center of the teaser for Jason Reitman's upcoming drama Men, Women & Children. As its tag taunts, "Discover How Little You Know About The People You Know. "
We're seeing this licensing issue pop up in several movies now as the line between film and advertisements is starting to vanish. These specific video game characters already popped up, along with newer ones, in Wreck-It Ralph, and a similar tactic was used in The Lego Movie, which utilized Lego versions of Batman, Superman, the Ninja Turtles and NBA players among other familiar brands.
My first thought looking at this shot of Michelle Monaghan, Adam Sandler, Josh Gad and Peter Dinklage is WHAT have they done to Peter Dinklage?
But Sandler is nothing if not a survivor, and he's very close to jump-starting this lull in his career. He's diversifying with both the comedy-drama The Cobbler with writer-director Tom McCarthy, and he's leading the ensemble of Men, Women And Children for director Jason Reitman.
When it comes to taking the hard earned money of both the audiences and the studios that foolishly offer it, Adam Sandler is Hollywood's Bernie Madoff. His films are mini Ponzi schemes, designed to lure audiences into thinking they're getting what they want, only to keep luring them in with each subsequent release.
A definitive comment on the best romantic comedies ever made. Its littered with beautiful love stories, hysterical lines and even rodents of unusual size.
Family shenanigans ensue in the new Blended trailer. The comedy will bring Adam Sandler and Drew Barrymore back together, this time as single parents who find themselves trying to get along while on a luxurious African vacation.
Regardless, The Peoples Choice Awards were held last night and it was announced that the Favorite Movie of the year was Shane Black'sIron Man 3 - which actually is about to be lapped by The Hunger Games: Catching Fire as 2013's biggest film. Apparently The Hunger Games was released after the cutoff date for this celebration of avarice.
Hearing what director Tom McCarthy has to say about his upcoming film The Cobbler makes me really want to see the trailer for this film. Alas, its a bit premature for that, but we do have our first look at Adam Sandler as a shoe repairman who looks like hes still in the process of starting his day in this photo.
Regardless of how an Adam Sandler comedy turns out upon full viewing, the trailers for his films continue to promote themselves as comedies that are both bottom-feeding and written by a class of middle school students who dont like each other. With this in mind, watching Blended was still a shockingly bizarre experience, and I dont understand how it didnt say Based on a Simpsons Episode after the title screen.
Once upon a time, Adam Sandler churned out comedies with very modest budgets. They did pretty well at the box office and everyone involved turned a tidy little profit, leading to new greenlights and more creative freedom. Unfortunately, along the way, the budgets started getting bigger and bigger and long story short, hes now apparently the most overpriced actor in Hollywood.
Watching him as the star of Boardwalk Empire, it may be easy to forget that Steve Buscemi tends to pop up in Adam Sandler movies from time to time, the most recent of which would be Grown Ups 2. It appears the two funny men will be reuniting once again in Tom McCarthys upcoming film The Cobbler, in which Adam Sandler will star as a shoe repairman who integrates himself into the lives of the people whose shoes he fixes. Also joining the cast is Dustin Hoffman.
White the source doesn't say if McCarthy wrote the script for the film himself - as he has with all three of his previous directorial efforts - it's noted that the story centers on a shoe repair man (played by Sandler) who somehow has the metaphysical ability to experience lives through other people's eyes "for a certain period of time."
Published in 2011, Kultgens novel is a character study focused on the modern American family, and how technology and the internet have completely altered the familial landscape. Its about the overt sexuality of teenagers and the repressed sexuality of their parents. Its about making connections and the construct of the identity.
When people tell you the reason to see Grown Ups 2, it generally boils down to the idea that it's fun to spend time with Adam Sandler and his buddies goofing off. And even if you're not a fan of the actual movie, like I was, it's still true in real life: being in a room with Adam Sandler, David Spade, Kevin James and Salma Hayek is just fun. Especially when the four of them are clearly cooking up pranks together before you ever walk into the room
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The Introduction to Online Learning Class (ACS 1035)
Are you new to e-Learning or do you want to "try-out" online classes? Introduction to Online Learning, a completely online training class, focuses on teaching you the necessary e-Learning skills to be successful in online and blended classes.
We allow two weeks to complete the class work. But because this class is self-paced, you may finish in far less time. A few of the topics covered are Blackboard's interactive communication tools such as blogging and creating discussion board threads, tips and tricks for time management, and using the online library databases for research.
Depending on your academic experience, successful completion of this class may be a requirement.
The course fee is $25, which is non-refundable. If you are a United Association members, alternate payment arrangements have been made through the UA.
You must submit a request online to register for this course. You cannot register for Introduction to Online Learning through WCC 's traditional class registration area in the WCC Gateway.
Online Class Full?
We offer blended versions of many online classes. In most cases you just come to school once a week, and you gain the benefit of face-to-face discussions with your instructor and fellow students.more »
Get Advising From Home
Save a trip to campus. Just fire up your computer webcam and microphone to talk to an advisor online.more »
What Students Say About Online Classes
"When I took an online class for the first time I was amazed at how organized it was. It was so easy to navigate and provided me with all the links and tools I needed to complete my course."—Mary Beth H., 30


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Dominique Rodgers-Cromartie lined up at right cornerback, and Juan Castillo called his number.
It was time to use his elite speed and surprise Vince Young with a blitz.
Rodgers-Cromartie flew in a straight line, chasing Young to his right for the eventual "sack" in the red zone.
"I never did it [in Arizona]," Rodgers-Cromartie said, when I asked him about his previous experience as a blitzer. "But that is something I am looking forward to, coming off that edge."


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Policing Domestic Violence
program date:Mon, 08/02/2010
Tanya Brannan, founder of the Purple Berets, describes how and why police responses to domestic violence are often useless or worse than useless. She talks with the Old Mole's Bill Resnick.
- Title: Policing Domestic Violence
- Album: August 2, 2010
- Length: 17:40 minutes (10.11 MB)
- Format: MP3 Mono 44kHz 80Kbps (CBR)
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text:
Google's first website on eco-tourism
Google is always on its toes with innovations. It has launched its first map-based mashup site. It has all information to get you on wheels for a earth-friendly tour. The website contains information about earth-friendly locations in five destinations of the U.S.'s top travel spots.
Luanne Calvert, creative director at Google said,
This is important to us… One of the big objectives for Google as a corporation is to promote environmental protection.
The five green tourist destinations are San Francisco, Los Angeles, Las Vegas, New York and Orlando, Fla. Just visit the site, at maps.google.com/green. Hetre you will get information spots, including video tours. Inn addition, it also provides tips on how to be an eco-tourist during the summer using Google Maps.
More listings, cities and countries will be enlisted in the future.
Calvert said,
The goal is to have everyone using Google Maps to get around this summer… The motto is Green not Grim…green can be fun.
She further said,
By green Google means things that are earth friendly… That includes restaurants that are about sustainable living and a car service in New York that only uses (gas-electric hybrid) Prius vehicles.
Via: NEWS.com


text:
- Home /
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text:
Nanny in Haverhill
Babysitter in Haverhill
- Age:
- 49
- Gender:
- Female
- Marital Status:
- In Relationship
- Smoker:
- No
- No. of Children:
- 2
- Join Date:
- 13 March 11
- Last Login:
- 19 January 16
- Location:
- Haverhill
- Rating
- no reviews
- Mobile Phone:
- View Information
- Email Address:
- View Information
My Summary
|Part Time Nanny
|Full Time Nanny
|Live In Nanny
|Live Out Nanny
|Night Nanny
|Full Driving Licence
|CRB/DBS Check
|First Aid Training
|Own Car
|Evening Babysitter
|Weekend Babysitter
|Daytime Babysitter
|Newborn Experience
About Me
Hi Ive been a Nanny for 30 years, I have 2 children of my own aged 24 and 25and two grandsons aged 5 and 4
My Experience
I have worked with all ages of children from birth onwards including multiple births. Ive had sole charge as well as shared care.
My Qualifications
I hold a current CRB and first aid certificates
My Availability
I am available for evening or weekend babysitting. I can babysit daytime or evening at the weekends. This can be a one off or permanent thing.
Please feel free to contact me
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This profile has been produced from information provided to us by the user. We have not verified or confirmed the accuracy of the information and members should take their own checks and references


text:
The North Face Concavo Full-Zip Fleece Jacket - Women'sView Larger Image
The high-tech The North Face Women's Concavo Full-Zip Fleece Jacket wicks away moisture, dries quickly, breathes, stretches, and delivers lightweight, efficient warmth to bring you optimal comfort. See, the FlashDry technology isn't for ostentation; it's why you can layer on this lean jacket and feel cool, dry, and cozy all at once. And flatlock seams and seamless shoulders provide chafe-free comfort, even when you're wearing a backpack. Wear it with a shell in snowy weather or by itself when going light, fast, and aerobic.
- Hardface stretch polyester fleece with FlashDry wicks away sweat, dries in a flash, breathes, stretches, and provides exceptional an warmth-to-weight ratio
- Flatlocked seams prevent chafing and discomfort
- Reverse-coil center zip lets you control coverage
- Seam-free shoulders comfortable accommodate a backpack without pressure points or chafing
- Two secure hand pockets hold essentials


text:
Emporio Armani 3001, 52 mm
105.00 91.00 » promo price This price is already free of VAT. A Tax Refund cannot be requested. The amount in USD is for your reference only, payment will be settled in US Dollars.
- Colour code: 5071
- Size: 52 mm / 17 mm / 140 mm
Frame colour: Violet transparent
- Lens colour: *
Please contact our Help Desk if you wish more information.
- This shape better suits a face:Additional product information:
Men's N/A Plastic
UPC Code: 8053672034592
- The Social Comments are posted on your Facebook page and are visible to your friends. If you wish to communicate with us, please contact our Help Desk - Thank You!


text:
Be a good steward for the obvious, the little things, and the personal quirks. Don't be Denethor.
Updated for Magento 188.8.131.52 compatibility.
Inline JS within one-page checkout isn't executed in the global scope and that can break things.
Updated for Magento 126.96.36.199 compatibility.
Updated for Magento 220.127.116.11 compatibility.
Updated for Magento 188.8.131.52 compatibility.
What you pay for health insurance is governed mostly by where you live.
Acumen 2, MageFrontend, and GravDept's new platform are coming — soon.
Updated for Magento 22.214.171.124 compatibility with PayPal Bill Me Later support.
Five years ago Gravity Department began without a name.
Skinny Ties has produced and sold neckwear since 1971. GravDept redefined the company's creative and technical direction to propel shopping on every device. This is your introduction.
Attached are my slides and speaking notes from my presentation on mobile first, responsive design for eCommerce at Magento Imagine 2012.
Acumen is a commercial Magento theme project I started nearly two years ago, but have never written about before. Here's the story.
In June, Ning flew the winners and judges of its design challenge to NYC for dinner and celebration. This is a chronological telling of my experience.
Ning announced a design competition for their social network platform on March 10. The prize was $10,000 and dinner with a panel of designers worth $10k more. There was just one catch.


text:
Indulge yourself with a new quality bedroom set! Our collections are known for their outstanding quality and youll see why when you snuggle up with one of our divine duvet covers.
Compliment your interior design with our numerous themes; chose from bold contemporary patterns, intricate flower designs and luxurious embellished options. Many of our duvet covers come with free matching pillow cases too ensuring a complete and complimenting bed set!
This is an exquisite & opulent range with 300 thread count fabric made with the finest quality cotton.
A classic Oxford duvet cover using 100% cotton fabric.
Crisp whites contrast with a coloured border in this luxury percale duvet set.
This designer bedding by Elizabeth Hurley is inspired by Persian patterns and uses soft lime green colours.
This multi-coloured print by Zandra Rhodes is a great design for creating a contemporary and eye catching look within your bedroom.
Toronto is a super quality cotton blend embellished duvet in a stunning stripe pattern with plain border for a contemporary design.
An elegant and striking print in a contemporary floral pattern. Reversible.
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A vibrant patchwork duvet cover with absolutely stunning colours & patterns! Super soft cotton blend for added luxury.
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Polka dots on a soft pastel fabric for calming serene bedroom look.
An Oriental design featuring printed red flowers against a luxury cream base.
Floral bloom introduces gorgeous bright flowers on a crisp white base.


text:
Apr 22 2013, 6:18am CDT | by Luigi Lugmayr
The biggest news from the Paley Center for Media panel "General Hospital: Celebrating 50 Years and Looking Forward," which I moderated on April 12: Anthony Geary (Luke Spencer) will be writing a tell-all book. Among the topics he'll cover "after about three more people die" will be his love affair with Elizabeth Taylor, who guest starred on the soap in 1981. After the panel, Geary also told me about another GH actress with whom he had a relationship in the '80s.
During the laugh-filled hour, the panelists reflected on the show's most powerful storylines (Robin's HIV diagnosis, B.J.'s heart transplant), shared memories of beloved veterans who passed away and honored the widow and daughter of John Beradino, who played Dr. Steve Hardy from 1963 to 1996. Here's to 50 more years!
Subscribe to TV Guide Magazine now!
View original Keck's Exclusives: General Hospital Celebrates Its Golden Anniversary at TVGuide.com
Other Links From TVGuide.com
Source: TV Guide
Luigi Lugmayr
Luigi is the founding Chief Editor of I4U News and brings over 15 years experience in the technology field to the ever evolving and exciting world of gadgets. He started I4U News back in 2000 and evolved it into vibrant technology magazine.
Luigi can be contacted directly at firstname.lastname@example.com. Luigi posts regularly on LuigiMe.com about his experience running I4U.
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text: The wide range of services and facilities makes the establishment the ideal starting point for business and relaxation. The establishment features various services and facilities for a comfortable and relaxing stay, including internet access and wireless internet access. All accommodation units feature air conditioning and a bathroom. Tea and coffee making equipment is included as standard. In the rooms, guests will find internet access, a telephone, a TV and wireless internet access. A hairdryer can also be found in each of the bathrooms. Sport and entertainment options are available at the establishment. The establishment offers an indoor pool. A hot tub provides an opportunity for relaxation. Copyright GIATA 2004 - 2016. Breakfast is bookable as a board option.


text:
Bellamy Brothers Lyrics
4.0 / 5
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Do you like this artist?
(click stars to rate)
- ★
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|1234 lyrics
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|Afterglow lyrics
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|Back the F*** Up lyrics
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text:
Thank you for your interest in Fetch-A-Do Grooming Salon, located inside Redbird Pet Food Center. We pride ourselves on professional, kind and outstanding grooming performance.
Located in
Alma, Michigan
our salon was founded in 2004 and has quickly become one of the most popular destinations for dog and cat grooming. Many of our groomers are graduates of Michigan School of Canine Cosmetology, and are ready to help with all your grooming needs. We specialize in dozens of breed standard cuts, such as Schnauzers and Cocker Spaniels. Our most popular "puppy-cut" trim is a customer favorite as well as the all over "shave-down". There is no job (or breed) too small or large.
Fetch-A-Do operates with the most advanced technology and professional grooming products, such as the Clipper Vac System and BathMaster high pressure bathing system. We can customize a suitable grooming that fits you and your pets needs.
Please don't take our word for it, stop in and make an appointment today!
2324 W. Monroe Rd.
Alma, MI 48801
Pet Gallery
About Us
Contact Us
Website Designed
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List Your Business


text:
I have xbit and box 1.5
Im using my laptop no usb peripherals connected, hell i even took out my cd rom drive. I can connect to the xbit just fine, however if and when I follow the "soltution to flashing your xbit" instructions. Having 1-3 switches off and 4 on, when I connect the the chip to the usb the green light will not turn on. If I use any other bios bank the green light turns on. So, using a different bios bank 1 on and 2-4 off. I can connect to the chip using 1.5, when I try to write the x2 bios 4983.bin (renamed to bios.bin) It will start erasing and the number of block just keeps expanding (ex erasing block=10025 <this number just keeps going)
im not sure what to do next. My original hdd drive is wiped out of any folders so I cannot connect it. I tried using my friends oe hdd, without the chip and it gives me error 6, unable to unlock the HDD.
Can anyone help out with this one.
Flashing Issues, Yes Ive Searched!
Started by DizkokidD , Aug 25 2005 09:33 AM
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text:
when i was little, i always thought that
you were supposed to shine
with light that came from some distant kingdom
that none has ever seen
they said you should have wings
snowy, white and feathered;
only the special ones may have more than two
offering protection within a downy shield
but I've grown up since that age of whispered stories
I've found that they were wrong
the light i see in you, glows brightly from inside
guiding me through this land of shadowed dark
not needing wings to lift me up,
always helping me to find my way back
to a smile. your kind words bring,
send, my ever falling heart into a world
worth living
At a loss for words...beautiful is all i can really say.
What a beautiful piece.
In my opinion though of course including the image of an angel (which was the actual theme ) this was different. Liked the child and its beliefs. . . you've written such a lovely piece!
thank you very much, i din't really want to go for the obvious direct mention of an angel for this poem.
"but I've grown up since that age of whispered stories
I've found that they were wrong"
Certainly the strongest lines of the piece.
I've found that they were wrong"
Certainly the strongest lines of the piece.
*smile* Nice work.
So bright, cool, and calm. I've been banging on the keys in caps for the past ten minutes and this was like a soft, gentle pacifier. Nice imagery, nice narrative. Thank you.
this definitely does not suck. i like it a lot. wonderful job
This one sounds oddly petable >.>
what do you mean by petable??? >.<
I like it, theres only one thing in it i would really change though, its the 'shadowed dark' part, it seems a little redundant..maybe just shadows, or something else..nothing coming to mind at the moment.
but i likes!
but i likes!


text:
Ako Aotearoa Southern Hub
Tēnā koutou
Welcome to the Southern Hub page where you will find links to and information about who we are, how we operate, the tertiary projects we are funding and how to contact us.
Further information
- Background about the Southern Hub
- Regional Funding Scheme – Southern Hub project outputs
- Research register – search for Southern Hub projects
- Regional Hub Advisory Group
- Contact Us
Professional development workshops
Ako Aotearoa's national Professional Development
Programme is designed for educators and managers across the tertiary sector.
Upcoming Workshops:
Wednesday 27 January, 9.00am-4.00pm, Dunedin
Wednesday 17 February, 9.00am-4.00pm, Dunedin
Thursday 18 February, 9.00am-4.00pm, Christchurch
Thursday 25 February, 9.00am-4.00pm, Christchurch
Tuesday 15 March, 9.00am-12.30pm, Christchurch
Tuesday 15 March, 9.00am-12.30pm, Dunedin
Monday 4 April, 9.00am-12.00pm, Dunedin
Monday 4 April, 1.00pm-4.00pm, Dunedin
Tuesday 5 April, 9.00am-12.00pm, Christchurch
Tuesday 5 April, 1.00pm-4.00pm, Christchurch
Monday 11 April, 9.00am-12.00pm, Nelson
Monday 11 April, 1.00pm-4.00pm, Nelson
We welcome enquiries about offering these workshops at other times for specific groups or organisations, contact us to discuss a tailored workshop for your staff, group or organisation with special rates and time to suit.
Thanks for visiting our page, I look forward to meeting you soon.
Neil Andersen
Email: email@example.com
A feature of the Adult Learners Week - He Tangata Mātauranga (September 7-13, 2015) - was recognition by the Christchurch ACE Forum of the achievement of learners through the presentation of 'Outstanding Adult Learner Award" certificates at an Ako Aotearoa Southern Hub sponsored function.


text:
We read the positive reviews on trip advisor and expected a beautiful boutique hotel. The first thing to note is that this hotel is several miles from buzios and not in a great part of town. The hotel felt very old and worn. The whole place smelt damp and you could see the smell was coming from the moldy roof... More
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text:
51:1683(140)AR - - Treasury, U.S. Mint, Philadelphia, PA & Fraternal Order of Police, Lodge F1-PA - - 1996 FLRAdec AR - - v51 p1683
[ v51 p1683 ]
The decision of the Authority follows:
51 FLRA No. 140
July 30, 1996
Before the Authority: Phyllis N. Segal, Chair; Tony Armendariz and Donald S. Wasserman, Members.
I. Statement of the Case
This case is before the Authority on exceptions to an award of Arbitrator Robert Herzog filed by the Agency under section 7122(a)(2) of the Federal Service Labor-Management Relations Statute (the Statute) and part 2425 of the Authority's Regulations. The Union did not file an opposition.
The Arbitrator issued an award requiring the parties to obtain a list of arbitrators from the Federal Mediation and Conciliation Service (FMCS) and to submit a grievance to an arbitrator selected therefrom. For the following reasons, we conclude that the Agency has provided no basis for finding the award deficient. Accordingly, we deny the Agency's exceptions.
II. Background and Arbitrator's Award
After denial of its grievance challenging the suspension of a bargaining-unit member, the Union requested that the matter be submitted to arbitration. Fifteen days later, the grievant's attorney contacted the FMCS to request a list of arbitrators.
At this point, the Agency claimed that arbitration was no longer available to the Union. Although the Agency agreed that the Union timely requested arbitration under Article 29, Section 1 of the parties' agreement, the Agency asserted that the Union's failure to contact the FMCS within 10 days after its request violated Article 29, Section 2 of the agreement and rendered the grievance nonarbitrable.(1)
The parties agreed to submit only the question of procedural arbitrability to the Arbitrator, who framed the issue as follows:
Were the provisions of Collective Bargaining Agreement Article 29, Section 2 violated rendering the grievance concerning Officer John Greene's November 1, 1994 ten (10) day suspension not arbitrable? If not, what shall the remedy be?
Award at 2.(2)
The Arbitrator ruled that the Union timely invoked arbitration by satisfying Article 29, Section 1. The Arbitrator construed Article 29, Section 2 as merely administrative and, accordingly, found that the Union did not waive arbitration by failing to contact the FMCS within its prescribed time frame.
As his award, the Arbitrator ordered the parties to comply with Article 29, Section 2 by contacting the FMCS either singly or jointly within 10 days to initiate arbitration of the underlying grievance.
III. Agency's Exceptions
The Agency argues that the award does not draw its essence from the agreement. According to the Agency, Article 29, Section 2 requires strict compliance by the party invoking arbitration. Thus, the Agency asserts, the Union's failure to contact the FMCS in accordance with this provision rendered the grievance nonarbitrable.
The Agency also argues that the Arbitrator exceeded his authority. The Agency contends that by using the word "shall" to direct the parties to contact the FMCS, the Arbitrator improperly modified Article 29, Section 2, because this provision states that "either party may 'singly' . . . or 'jointly'" initiate contact. Exceptions at 2-3 (emphasis added).
IV. Analysis and Conclusions
The Agency's claim that the award does not draw its essence from the agreement is not properly before us. Awards resolving questions of procedural arbitrability are subject to challenge only on grounds other than those that directly challenge the determination of procedural arbitrability. American Federation of Government Employees, Local 2921 and U.S. Department of the Army, Army & Air Force Exchange Service, Dallas, Texas, 50 FLRA 184, 185-86 (1995) (AFGE). Such grounds include bias on the part of the Arbitrator or a showing that the Arbitrator exceeded his authority. Id. at 186.
The Agency's essence argument rests squarely on the ground that the Arbitrator improperly interpreted and applied the agreement's timeliness provisions. This argument directly challenges the Arbitrator's determination of procedural arbitrability and, therefore, is not reviewable. See AFGE, 50 FLRA at 186; U.S. Department of Veterans Affairs, Eisenhower Medical Center, Leavenworth, Kansas and American Federation of Government Employees, Local 85, 50 FLRA 16, 19-20 (1994).
Although the Agency's assertion that the Arbitrator exceeded his authority is reviewable, the Agency has not substantiated this claim. The Agency contends that the Arbitrator exceeded his authority by disregarding a provision of the agreement prohibiting arbitrators from modifying the agreement.(3) The Agency asserts that the Arbitrator's award, in effect, substituted the word "shall" for the word "may" in Article 29, Section 2.
This exception fails because the Arbitrator did not clearly violate an express limitation. See, e.g., U.S. Department of Defense Dependents Schools and Overseas Education Association, 49 FLRA 120, 123 (1994). Rather, the Arbitrator properly exercised his power under both the agreement and Authority case law to interpret related provisions of the agreement. See American Federation of Government Employees, Local 3258 and U.S. Department of Housing and Urban Development, Boston, Massachusetts, 38 FLRA 600, 605-06 (1990). The Agency's exception is merely an attempt to recast the Arbitrator's contract interpretation as an improper contract modification. As such, the exception does not provide a basis for finding the award deficient. Id. at 606.


text: Star Trek: Enterprise Series 3 - 23. Countdown Facebook Twitter Google Tumblr Pinterest Blogger Reddit VKontakt Print Email About this programme 23/24. Part one of two. Archer finds himself in a race against time when he has to make a pact with several Xindi factions to stop their superweapon being launched. Sci-fi drama, guest starring Josette DiCarlo, Mary Mara and Ruth Williamson. Cast and crew Cast Capt Jonathan Archer Scott Bakula Dr Phlox John Billingsley Sub Cdr T'Pol Jolene Blalock Lt Malcolm Reed Dominic Keating Ensign Travis Mayweather Anthony Montgomery Ensign Hoshi Sato Linda Park Cdr Charles `Trip' Tucker III Connor Trinneer Cdr Dolim Scott MacDonald Jannar Rick Worthy Major Hayes Steven Culp Xindi primate Tucker Smallwood Sphere-Builder Woman Josette DiCarlo Sphere-Builder Presage Mary Mara Sphere-Builder Primary Ruth Williamson Crew Director Robert Duncan McNeill Writer Andre Bormanis Writer Chris Black Categories Drama Facebook Twitter Google Tumblr Pinterest Blogger Reddit VKontakt Print Email


text:
Junior Member
Last Activity: 31st December 2015 12:41 AM
Contact Info
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Post Summary
Hello all, We have developed "2012 Apocalypse" free application for windows phone 7. Please review and give your comments. Any suggestions or improvements are most welcome. Thanks.
No need to open computer to tweak your pictures. The ultimate Photo editor on Windows Phone 7 is here. Now covert your memorable pictures into an immortal piece of art. Photo Hub helps you make great edits to your pictures. If you like to edit...


text:
To think this was a bit weird(17 Posts)
FrebbieMisaGREATshag Tue 14-May-13 08:27:16
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