text:
Express your style
Round or square. Traditional or modern. Wear it for fashion, fitness, or fun.
Customize your look
Thousands of watch faces from brands and developers.
Thousands of watch faces from brands and developers.See the collection
Make the most of your time
Get your info at a glance
Android Wear watches feature always-on displays, so you'll always see important info like time, calls, and alerts. Respond to messages right from your watch, even when your phone isn't with you.1
Follow your fitness
Stay motivated with built-in fitness monitoring and coaching from your favorite apps. Leave your phone at home, and listen to downloaded music and track distance on your watch.2
Save time with smart help
Stay on track with commute info, directions, and timely reminders. Say "Ok Google" to ask any question and check off to-dos—right from your wrist.
Stay on track with commute info, directions, and timely reminders. Say "Ok Google" to ask any question and check off to-dos—right from your wrist.
Pursue your passions
Cultivate your talents and explore new interests: Perfect your golf swing, learn a new language, or explore a new neighborhood. With thousands of Android Wear apps, you can always wear what you want.
Works with your Android phone or iPhone
Android Wear requires a phone running Android 4.3+ or iOS 8.2+. Supported features may vary between platforms. Visit g.co/wearcheck on your Android phone or iPhone® to see if it's compatible.
Choose your watch
Supported features will vary by platform, device, and country.
1 Please check with watch manufacturer to see if Wi-Fi is supported on your watch.
2 Use Bluetooth headphones to listen to downloaded music. Please check with watch manufacturer to see if GPS is supported on your watch.
iPhone is a registered trademark of Apple Inc.


text:
Seth, Dylan Horrocks AND Charles Burns?
Toronto, you are one lucky city! The International Festival of Authors is so mind-bendingly packed with amazing authors, and they always remember ol' comics with their programming. Tomorrow, October 23rd at 3pm, head down to the Harbourfront centre to see Seth, Dyland Horrocks and Charles Burns talk about their new work. Get your tickets here.
IFOA: Round Table Oct 23 3pm BRG
Saturday, October 23, 2010, 3pm
Brigantine Rm - York Quay Ctr
235 Queens Quay West
Submitted by Peggy Burns on Friday, October 22, 2010 - 6:06pm.

subset: commoncrawl


text:
NPR Newscast
4min 45sec
January 6, 2013 What attracts people to fantasy? Is it the orcs and the elves, or the rich worlds they inhabit? Author Saladin Ahmed says world-building — the craft of building a believable fictional world — provides "an almost physical sense of getting lost somewhere that isn't home, but which comes to be home."
October 20, 2012 Amazon is expanding its top 100 lists to rank writers, not just books. The new list features a funky mix of authors, from big names to children's classics to Ayn Rand. Essayist Amanda Katz wonders whether the list is silly, useful, a play for world domination, or possibly all three?
You never know, this woman could be reading The Gulag Archipelago.
hide caption
August 8, 2012 Commentator Amanda Katz muses on some seriously unbeachy beach book choices, from the guy in a Palm Springs pool reading a book on string theory, to the woman curled up on the lounge chair with William Styron's memoir of depression, Darkness Visible.
June 21, 2012 An old copy of The War of the Worlds, once belonging to rocket scientist Robert Goddard, prompts essayist Amanda Katz to muse on what we lose when we stop reading — and passing along — physical books.
A baby is snatched away by goblins in Maurice Sendak's Outside Over There. The beloved author and illustrator — who took a darker approach to children's storytelling — died Tuesday at the age of 83.
hide caption
May 9, 2012 A baby is snatched away by goblins in Maurice Sendak's unsettling children's book, Outside Over There. Commentator Amanda Katz says she loved this book as a child, and only later understood why it made adults so uncomfortable.
April 20, 2012 Some of the best poets of spring are masters of the minor key. So it's no surprise that the famously dour Philip Larkin wrote two of the finest spring poems of the last century, according to critic David Orr — who offers his appreciation.
April 17, 2012 To Kill a Mockingbird and Valley of the Dolls have more in common than you think. In his new book Hit Lit, mystery writer James Hall argues that best-sellers from the past century share 12 features.
April 12, 2012 The Department of Justice's lawsuit against Apple and five major publishers for e-book price fixing sent shivers through the industry — but Jason Boog says this fraught relationship between American publishers, retailers and the DOJ goes back to the Great Depression.
March 13, 2012 Sky looking a little slatchy to you? Want another helping of slang-jang? The final volume of the Dictionary of American Regional English, a 50-year project to document English across the U.S., is a treasure trove of history and local color.
February 13, 2012 Valentine's Day is a tricky occasion for poets. Granted, it's hard not to be happy about a holiday on which poems are thought to be genuinely useful. But love poetry's record as an aphrodisiac is mixed. Critic David Orr offers advice for romantic rhymers.
An Andre Gill caricature of the novelist with his own books under his arm.
Hulton Archive/Getty Images
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February 9, 2012 He's trending on Twitter, inspiring Google Doodles and hawking hoodies. Why Dickens has always inspired such adoration — and why the book business should pay close attention.
January 31, 2012 Bestselling novelist Jonathan Franzen came out heavily against ebooks, but, really, who cares?
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text:
Best Lunch for Two Under $10 (2004)
Jade Garden
Sure, the building looks vacant from the street, and it sits in a neighborhood that can get rough after, like, 10 a.m., but please look beyond this, for Jade Garden is one of the best Chinese restaurants in Dallas, a place as filling as it is good as it is cheap. And this last point is the true measure of its worth. At Jade Garden, two people can have a soup of their choice, water and an entrée for $3.50 each. Three dollars and 50 cents. That's $7 for whoever's buying. And go ahead, throw in tax and a tip. If you pay with a 10, you're still stuffing a bill in your pocket when you leave. And you're leaving full and satisfied: The food is served quickly but doesn't taste like a chain restaurant. It tastes, instead, like the steal it is.
More Awards from This Winner
Location Details
More Food & Drink Awards
Best Children's Restaurant on SaturdayHooters
Best WaitstaffIl Mulino New York
Best ComebackTipperary Inn
Best TortillasTaco Cabana


text:
Michaela L.
Report | 3 months ago
Awesome workout Great staff and you see and feel results quickly
Was this helpful?
Whether they're seasoned athletes or trying out their legs for the first time, students at B.E.A.S.T. Fitness work on their bodyweight, endurance, agility, and strength training. Beginner-friendly Basix classes run every night with instructors motivating students through Pilates, cardio-conditioning, and upper- and lower-body workouts. More intense workouts take place in the morning, when athletes embark on an Death March through a gauntlet of obstacles and make their way through the HIIT training of Station Obliteration.
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text:
Glory at Oregon, but at what price?
The Ducks appear to be joining the litany of major programs in dutch with the NCAA
Originally Published: July 7, 2011By Gene Wojciechowski | ESPN.com
It began with a billboard.
And not just any billboard, but an audacious, first-of-its-kind, quarter-million dollar piece of advertising placed in the middle of Times Square. It was an image-changer, a Hail Mary pass that the Oregon football program completed for a publicity touchdown. Suddenly, everyone knew about the Ducks.
Now, 10 years after the 100-foot-high Joey "Heisman" Harrington billboard made its debut in faraway NYC, Oregon football has everything it craved: ...
Read full story
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text:
Speaker Lili Cheng
Duration 00:28:41
Date recorded 17 July 2012
In this interview during the 2012 Microsoft Research Faculty Summit, Lili Cheng, general manager of Microsoft FUSE Labs, talks about the role of social media in research.
©2012 Microsoft Corporation. All rights reserved.
By the same speaker
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text:
To want to punch people who say - "cheer up love, it might never happen"(129 Posts)
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text:
Infinite Revolutions
Credits & Info
- Date
- 01/12/2013
- File Info
- Song
- 5 min 9 sec
- Score
- 4.63 / 5.00
Related Content
You might also enjoy:
Licensing Terms
You may not use this work for commercial purposes without making specific arrangements with the artist UNLESS your work is a web-based game or animation, in which case you may use this freely.
- Score:
- Rated 4.63 / 5 stars
- Plays & Downloads:
- 1,796 Plays | 138 Downloads
- Share Links:
- Genres:
- Metal, Rock - Indie
- indie
- rock
- infinite
- revolutions
Author Comments
Rated 4 / 5 stars
This is really good.. :)
Rated 4 / 5 stars
great job! please get rid of the auto-tune or lessen the effect of it at least, it really does seem out of place. your sound is great keep going!
no auto-tune, it's just a large amount of reverb, used to simulate singing in a chamber.
Rated 5 / 5 stars
Jesus...The amount of, overall ~felling~ and hard work in this are amazing.
I cannot speak no more about the gift of yours.
Rated 4.5 / 5 stars
Very nice sound... the sporadic percussion gives an almost early architecture in helsinki sound and the production and balancing is very impressive. still half a star for that auto tune which is very obvious and seems out of place. Still, fantastic song!!!


text:
Energy and Power Subcommittee Approves Bill to Analyze Impacts of EPA's Regulatory Train Wreck
WASHINGTON, DC - The Energy and Commerce Subcommittee on Energy and Power, chaired by Rep. Ed Whitfield (R-KY), today approved legislation to hold the Obama administration accountable for the total cost of EPA's wave of biggest rules. H.R. 2401, the Transparency in Regulatory Analysis of Impacts on the Nation Act, or TRAIN Act, was approved by the subcommittee by voice vote. The bipartisan bill now moves to the full Energy and Commerce Committee for consideration.
The TRAIN Act would require a cumulative analysis of major new rules recently proposed or promulgated by the Environmental Protection Agency. This interagency analysis will provide a greater understanding of the global competitive and economic impacts of these rules. The subcommittee approved the TRAIN Act today for a second time; as an earlier version of the legislation passed the panel in May, also by voice vote. The bill's authors, Energy and Power Subcommittee Vice Chairman John Sullivan (R-OK) and Rep. Jim Matheson (D-UT), reintroduced the bill to place a ceiling on possible costs of the legislation and provide offsetting spending reductions, although it is expected that agencies will be able to complete the necessary economic analysis through existing resources by improving and better coordinating the studies they already conduct.
"I would like to applaud the efforts of Mr. Sullivan and Matheson on this bill," said Chairman of the Energy and Commerce Committee Fred Upton (R-MI). "The ultimate goal of the TRAIN Act is to preserve jobs and American competitiveness by providing information necessary to harmonize these regulations. This legislation represents a worthwhile attempt to provide information that could help avoid substantial and unnecessary regulatory costs in the years ahead."
"The Obama Administration's lack of regard for the consequences of their energy and environmental policy is killing our economy and costing American jobs. It's absurd for taxpayer funded federal agencies to impose burdensome regulations on consumers and businesses without first determining how much it's going to cost and the potential consequences it could have on our overall economy," said Sullivan. "Our national unemployment rate rose to 9.2% over the past month - this further illustrates the need for an honest accounting of how much EPA's regulations are costing our economy and American consumers, and that is exactly what the TRAIN Act will accomplish."


text:
Ever the caring provider and girl with huge breasts, Nicki Minaj posted a series of photos from her new music video shoot for the song "Senile" on Instgram yesterday, and they actually answer some very important questions about the state of the music industry. For example, did you know that music artists still make videos? Apparently they do even though it's a stupid waste of money since people barely have the attention spans to listen to entire songs anymore, and most of the visual storytelling of music videos has been replaced by a dick-measuring contest to show off fancy, expensive objects and very little actual talent. So why in the world would Nicki bother making a music video if nobody gives a shit about them? Because tits tits tits, titty tits tits tits tits, pay the lady her money now.
Nicki Minaj's Breasts Made Another Music Video
(1) Comment
dianeapotter 03/17/2014 14:10
You will want to quit your job tomorrow when you try this system and start getting paid online $7362 in 1 month. Go now….
>>> ᵂᵂᵂ . f i s c a l p e n . ᶜₒᴹ <<<
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text:
Top Deadliest And Most Intimidating DC Villains of All Time
Kaley Cuoco Shows Off Her Tennis Skills
The Horror Games You Have to Play This Year
The Best Movie Trailers of 2015
20 Movies You Need To Watch At Home This Week
6 TV Finales That Failed Spectacularly
Our New Favorite Director and Star Duo for Captain Marvel
10 Celebrities Who Quit Hollywood Forever
First Look At Leaked Warcraft Movie Trailer
Grant Gustin Teases 'Big Twist' at End of The Flash's First Season
15 Interesting And Little Known World Facts
6 Actors Who Almost Died Filming
Game Of Thrones Season 6 Delayed!
10 Actors Who Do The Same Thing In Every Movie
Will The Hulk Come Back?
12 Wolverines The X-Men Are Ashamed Of
The 15 Biggest Oscar Snubs Of The Past 20 Years
8 People Who Must Be Fired From The Marvel Cinematic Universe
15 Easter Eggs You Missed in Guardians of the Galaxy
New Wonder Woman Photo Revealed as Filming Begins, Cast Announced
6 Films That Prove a Great Fantastic Four Movie is Possible
Ridley Scott on Why Prometheus 2 is Now Alien: Paradise Lost
New Doctor Who Spinoff Announced!
James Cameron Boasts About Avatar 2, 3 and 4
Marvel Studios Announces New Dates and Titles
The 10 Fall TV Shows We Can't Wait To Watch
10 Cancelled Movies That Would Have Made Billions
10 Questions That Zombie Movies Never Answer
Why Ex Machina Flopped On The Big Screen


text:
Mikkeller's interpretation of the typical Pilsner draft beer is, wouldn't you know it, not quite typical. It's no four-something alcohol, it's big, it's draft horse big--no, not "those" draft horses--it's a full 8% abv, with powerful hop notes, but a clean Pilsner style taste of lager yeast. Ingredients: Water, malts (pils, carapils and amber), light candy sugar, hops (amarillo and cascade) and lager yeast.
The item you have chosen is not in stock in our retail stores or within our main warehouse.
Bell's Brewery "Two Hearted" India Pale Ale, Michigan (12oz)
Bell's Brewery "Two Hearted" India Pale Ale, Michigan 16oz Can
Founders Brewing Co. Breakfast Stout, Michigan (12oz)
Bell's Brewery "Oberon" Ale, Michigan (12oz)
Badoit Sparkling Water (750ml) (Glass)


text:
Revision as of 22:03, September 6, 2010 by Arrancar79 (Talk | contribs)
| User talk:Arrancar79
Hi, I'm Arrancar79. Currently working on general grammar and spelling edits, as well as correcting vandalism. If you have any questions, or have some pages you'd like me to look over, feel free to drop me a line.


text:
Tim Holtz Stamps
Tim Holtz Cling Rubber Stamps ARTISTIC COLLAGES Stampers AnonymousCMS043 / 4.1
Project Lists
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This New stamp set has thick foam with deeply etched rubber. There are 4 different rubber stamps that can cling mount to any clear acrylic block (clear blocks are not included in this sale, but are available through our store!). What a space saver! They are part of a line of stamps designed by Tim Holtz.
The stamps are also neatly trimmed. They each measure approximately 2.5" by 3.5".
The stamps are also neatly trimmed. They each measure approximately 2.5" by 3.5".
You May Also Like...
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Tim Holtz Stamps
Tim Holtz Rubber Stamp BOLD SCRIBBLE O CHRISTMAS TREE Stampers Anonymous D52700
Stamps designed by Tim Holtz for Stampers Anonymous! Proudly made right here in the USA!


text:
No products
New product
You've read all the books, but you still want to know what it's REALLY like in those first few months after having a baby. Your wife/daughter/daughter-in-law/sister/friend is about to deliver and you want to know what you can do to help her.
This product is no longer in stock
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Mother to Mother
You've read all the books, but you still want to know what it's REALLY like in those first few months after having a baby. Your wife/daughter/daughter-in-law/sister/friend is about to deliver and you want to know what you can do to help her.
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You've read all the books, but you still want to know what it's REALLY like in those first few months after having a baby. Your wife/daughter/daughter-in-law/sister/friend is about to deliver and you want to know what you can do to help her. If you are asking yourself these questions, this book is for you! Author Kathleen McCue surveyed mothers in her practice to find their answers to 20 questions, including "What is the most important advice you received before birth?", "What was the most unexpected part of becoming a new mother?", "What things did spouse/family/friends do that were helpful/not helpful?", and "What would you do differently next time?"
Sample survey comments included those such as:
-"Boobs are like children and require structure and predictability."
-"Support and reassurance. No gadget or book helped me more than people telling me that I was doing a good job and just needed to stick with it."
-"Make lists before the baby comes for things you'll need--grocery shopping, pets' grooming appointments, vacuuming the house... People will want to help you, so have a clear idea of what you'd like them to do."
-"Really, really sleep whenever you can."
-"My in-laws insisted on coming to visit for an entire week right when the baby was born. While it was nice to have a hand around the house, it was actually pretty stressful having visitors staying at my house during that time. I wish they had come a couple of weeks later."
-"I wish my husband had complimented me on my pregnant body."
-"A certain unnamed relative loved to take off with my daughter, even if she was crying, and she would just say 'oh, babies cry sometimes' without giving her back to me. This drove me crazy!"
Author McCue follows up the answers to each survey question with her thoughts, suggestions, and advice. This book really "tells it like it is!" And sometimes it's not easy and doesn't always come naturally, as you'll learn from the mothers' comments. But knowing what to realistically expect and being prepared may make your own experience easier and better!
Author: Kathleen McCue, FnP, IBCLC
Copyright: 2012
Total Pages: 256
© International Lactation Consultant Association
ILCA Print and Multimedia Reviews
May 2012 – Available at www.ILCA.org
Mother to Mother: Honest advice from women who have been through it already
Kathleen F McCue, MS, RN, FNP-BC, IBCLC
Hale Publishing, 2012
252 pages, resources, no index, US$19.95, softcover
Orders: Hale Publishing, 1712 N. Forest Street, Amarillo, TX 79106 USA
Tel: 800-378-1317, fax 806-376-9902
E-mail: email@example.com
URI: www.ibreastfeeding.com
The journey to motherhood can be both very exciting and scary. In this new book, Kathleen McCue has tried to give mothers a realistic view of what to expect as this journey begins. In the foreword we read that mothers get bombarded with information from many people including family and friends. During the wait for baby, one group that often is not heard from is the "chorus of peers." Mother to Mother has captured the comments of this group through a questionnaire that looks to honest feelings and experiences.
The 57 respondents from all walks of life, ages, and birth experiences are women the author knew while working in a pediatric practice. The questions were developed in 2 parts and then distributed by email or letter. The mothers were asked to answer questions about birth and breastfeeding honestly; not all moms answered each question.
The responses are very interesting and in some cases eye opening. For example: "What one thing helps more moms succeed at breastfeeding?" A mother who is in the throws of it answers: "Talk to other moms who have been through it while … you will think, "I can't do this anymore. I have a leech … This baby wants to eat 20 out of 24 hours!" Having friends who can tell you that you will come out the other side is what got me through it" (p. 49). Another example: "Do you have a favorite gadget you either purchased or devised?" (p. 123). Answer: "Definitely my breast pump."
At the end of each question section the author summarizes and gives her thoughts on some of the answers. In some sections, she clarifies misconceptions and incorrect information. For example, in the section Three Most Helpful Coping Strategies, she responded to a comment on alcohol and improving milk supply (p. 142).
Mothers make the best decisions when they have all the information and they are continually seeking that information. How they process the information may empower them to meet the challenges or may frighten them to dig deeper for answers. This book has the potential to foster both.
Vicki Carlson, IBCLC
Oak Island, North Carolina USA


text:
Vector - Mane 6 Welcome Tower by Ready2FailWatch
©2013-2016 Ready2Fail
Made in Adobe Illustrator CS6. .AI file here: sta.sh/01r0qog18mkp. .SVG file here: sta.sh/01sb5xw0dux7.
Made this, to celebrate the season 4 premier. By some holy act of Celestia I managed to get just enough internet to stream the episodes, yet not enough to upload this at the time. Sorry!
I also went and made each pony work as a stand-alone, you can find those below.
Individual Pony PNG's (if you want just the image of a single one):
Twilight: sta.sh/0285ffusknl
Rainbow: sta.sh/021woxkz1fff
Rarity: sta.sh/0kb4cna6jxg
Fluttershy: sta.sh/0bj3effzii2
Applejack: sta.sh/01foqt730g6k
Pinkie Pie: sta.sh/01ql57de5laj
All individual image bundle: sta.sh/21b7xr7okhe1
Feel free to use any of the images, just let me know, and credit would be greatly appreciated.
EDIT: Fixed RD's mane & tail outline color, and colors within.
The order makes sense, earth ponies on the bottom then unicorns and pegasi on top.
Season 4 premier? Twilight forgot her wings in home. Xp
This was meant to commemorate the start of S4, the screen was from S3 Ep12.
Cute and cool at the same time!<br / />
Thanks lol
Never thought Pinkie would be that strong.
That Earth pony strength man, can't ever underestimate the raw power! :3
No problem.


text:
Entries for month: April 2012
Which Blog Software is right for me? How do I get started? Who can help me?
These are all valid questions! And there are no easy answers.
Most of the time your decision will depend on a few variables you will need to consider. And, sometimes, after writing (blogging) for a year or so you may decide your original assumptions are out of date or have changed.
What does one do then? Start over? Shell out more money to convert your original site?
Our team deals with a variety of different software writing/blogging packages - and we've tried many more. Each has its advantages and disadvantages. The world of Internet communication is filled with trade-offs.
So let' get started...


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text:
I ask because I have been giving my little man Prevacid for a long time, but it quit working for us (not that it ever was perfect) a few months back. I took him to the pediatrician (am between GI's right now) and asked specifically for Nexium. I gave it to him, 20mg once per day for two days only. He felt terrible all night both nights, worse on the first night. I did realize after the first night that I had unknowingly given him half a day's dose of Prevacid and a whole day's dose of Nexium on the same day, and he did seem like his discomfort was a medication overdose rather than acid or whatever. But I expected that to be over by the next night. I guess what I'm asking is how did your LO do when you switched to Nexium? I skipped giving mine his PPI at all last night to give his tummy a break and he slept OK last night, but I know he needs to take one today or he won't continue to feel OK. My pediatrician is just a reglar Pedi, so doesn't know much about the different PPI's. What would you do in my shoes? Go back to giving him the Prevacid even though that isn't doing enough and he's been doing badly on it (but better than those two nights on the Nexium), give the Nexium another shot tonight to see if it would work, or should I go back to the pedi and ask her what to do? We tried Prilosec once years ago and the first dose didn't work, but we didn't continue to adjust it because I was out of town. Are there any other PPI's besides those three? Any advice would be greatly appreciated!
How did your child do with Nexium?
Becky E. Wife to Ali since 2001 Mommy to Lucas since 9/28/09
Comments (8)
One thing with Nexium - it is a stable form of PPI since you mix it right when you give it. Was the Prevacid a compound? If so - I'd continue with the Nexium and give alot of gas drops - use Mylanta at 1st night waking (if 4 hours from the Nexium) Do that for 10 days. This is what I would do. Because switching a not so effective PPI for one that is more effective can cause an increase in issues while the body adjusts and tries to compensate for the parietal cells shutting down - the chemical reaction often produces gas that is painful - but temporary. Hope this makes sense.
My DD was on Prevacid compound, Prevacid solutab, Prilosec compound (no flavor mixed every 2 weeks) and Nexium. Of all - for her - the Nexium was the best option for prescribed PPIs.
This is my experience & opinion for my daughter. :)
Thanks for the info! He has been on Prevacid w/TCM for about a year and a half, which worked much better than pharmacy-compounded Prevacid and lacked the nasty side effects we got with the solutabs.
What do you mean about it being a stable form of PPI and mixing it right when you give it?
Also, my kid actually has eosinophilic esophagitis, and has stopped eating almost completely. My pediatrician told me to pour it over applesauce and give to LO, but he tested allergic to apples and is intolerant to dairy and soy and basically is not eating anything soft that I could put this over. The first time I dosed, I tried pouring the beads into a medicine dropper and mixing with gatorade (similar to what we used to do with Prevacid solutabs) and the second time, I tried pouring directly onto his tongue and then giving him something to drink (yes, this last one was a comically bad idea). The only idea I've been able to come up with for dosing the Nexium properly is to pour it over a small quantity of dairy-free, soy-free butter, since he will eat that, straight up. Do you have any suggestions?
Becky E. Wife to Ali since 2001 Mommy to Lucas since 9/28/09
Is the nexium the packets or capsules? DS was on the caps after reflux solutions closed its doors and we ran out of TCM. We mixed it with yogurt. It worked fabulous. You may want to consider breaking the 20 mg into 2 10mg doses.
Proud mommy to...I 5/07 & L 3/10
I was under the assumption that your LO was on the NExium packets that get mixed just prior to dosing - sorry.
I would definitely go with the butter or the yogurt as earlier suggested. You'll want whichever your LO will tolerate and it needs to be acidic when using beads from a capsule. I've heard of Moms putting bead into mouth and rinsing down with clear pedialyte.
Good question about the TCM too princesspeanut - the home mixing kits saved us
The Prevacid just hasn't been doing it for LO for the last several months. If we increase his dose, he has bad side effects, but his condition is not well controlled at the dose he was at before. I asked the pedi for the powder packs, as I've heard of others using those, but she had never heard of it and it wasn't in her reference book...
Yogurt is like the only dairy we've never tried (well, I keep him away from ice cream too, I guess). Can they tolerate yogurt even if they can't tolerate say, cream cheese or cottage cheese?
Becky E. Wife to Ali since 2001 Mommy to Lucas since 9/28/09
Proud mommy to...I 5/07 & L 3/10
Proud mommy to...I 5/07 & L 3/10
I agree with splitting up the dose. My DS is only 5 months but he always had bad feeds in the a.m. after a 10 mg dose. I never made the connection. I just kept thinking, if it's not working he needs a higher dose. We added a second dose of 5 mg and he still had better evenings then mornings, but when we upped it to another 10mg dose in the evening, he had a hard time after that second dose it finally dawned on me! We wound up doing the ph probe study b/c it really made me think Nexium was just making it worse and did he even have acidic reflux? Turns out his reflux is 50/50 acidic vs. non acidic and right now we are going with two 5mg doses. So the original dose was not the problem, he just needs it split into 2 doses vs one.
DD 1-21-10 Silent Reflux, former bottle refuser, never found "the cure". DS 1-12-12 Aspirates and laryngopharyngeal reflux Gtube weaned


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78 comments found.
Hello guys,
I've tried to install this theme: NativeChurch – Responsive HTML5 Template I got this error message:
Unpacking the package… Installing the theme… The package could not be installed. The theme is missing the style.css stylesheet. Theme install failed.
I use a zip archive nativechurch.zip, where I have included only template files.
I need some help to install this theme.
Hi there
Sorry for the trouble but you have purchased HTML version of NativeChurch as its name says. You should purchase Wordpress version here: http://themeforest.net/item/nativechurch-multi-purpose-wordpress-theme/7082446
Hello, good afternoon!
I just bought the theme with you, but it is giving error in Slider and also not with the MEGA MENU like DEMO.
And is not this page HOME VERSION 5.
How can I solve this problem?
Hi there
Please create a support thread at our support forum NativeChurch HTML forum: http://support.imithemes.com/forums/forum/html-templates/native-church/#new-post
I did not understand.
Where am I going? where should I click?
There is no area to solve these problems does not?
Just send the link to download the puglins needed.
index4.html is the version home page 5 as index.html is home page version 1
About the slider issues you need to create a support thread at the link i posted above with more details about the problem.
Hi I was just wondering, is there anyway to "force" all album images to be the same size? at least just on the masonry display page? some images that are larger are causing a misalignment of the grid layout.
Also, how does one keep the theme updated? I believe I hadn't the check mark for "email me when this theme has updates" previously checked so I may have missed a few. Anyway to get updated now?
Hi there
In HTML version of NativeChurch the image size all depends on you, you can use any image size for all masonry grid items.
As this is a HTML template so updates don't come frequently, but you can always download the latest files from your ThemeForest's downloads page. For info about what was updated you can see threads at: http://support.imithemes.com/forums/forum/html-templates/native-church/
Hello. Love this theme! I'm just having trouble finding the file I use to change the events on the calendar. Where is it located?
Thanks in advance.
Hi there
events-calendar.html should be the calendar template. Info about changing/editing events on that has been added in the documentation of the latest update. If you need more assistance on this just create a support thread at http://support.imithemes.com
Hi!, I'm having problems with the google calendar. I did what the documentation says about it but it's not displaying on my website. Any ideas?
Hi there
Please check if you have updated files as we changed the calendar plugin to support new google api. Documentation was updated as well to configure that.
I already did that but nothing. Any suggestions?
Please create a support thread here: http://support.imithemes.com/forums/forum/html-templates/native-church/#new-post
Hi there, i really loved his theme. One problem i'm facing tho is changing the theme from wide to boxed. please assist.
Hi there
Please see this thread: http://support.imithemes.com/forums/topic/how-to-make-the-layout-boxed/
Thanks one more question pls. Is it possible to have a sticky nav bar when the body layout is boxed. I have been trying to achieve this config. Thanks
Hihi! I'm not too sure if it's just me or what but I tried loading the website on chrome and the drop down menu doesn't stay. I.e. I mouse to a menu, the dropbox menu appears and when I move the mouse to the dropdown menu, the menu disappears. Any solutions? Thanks!
Hi there
See this support thread for this: http://support.imithemes.com/forums/topic/solution-jquery-scripts-slider-menus-not-working-on-chrome-locally/
awesome! Thanks so much!! (:
Hi, anyone notice that February (in the wordpress version ) for events is spelled "Ferbrary" ? Can this be corrected? I am getting calls that I have typos for this on all my events for this month. If you direct me to the source where its pulling that from I can change/edit it myself.
Thank you.
Hi there
Can you please create a support thread here: http://support.imithemes.com/forums/forum/wordpress-themes/nativechurch-wp/#new-post so that my developer can guide you better.
no problem will do
Hello, I like your theme designs and I am interested in a couple of them. However, in order to easily edit them to adjust them to what I want I wonder if you supply precompiled source less/sass and js files for your themes and the base Bootstrap etc.
Thank you!
Hi there
All our HTML templates comes with CSS and JS files and all are based on Bootstrap (Except OkidoApp, Solotrio, Corestudio)
Hello and thank you for your quick reply, but I meant to ask if they come with the original Bootstrap less/sass (scss) files and, in case your own styles are built with a precompiler (again, less or sass), if you include the sources as well.
Sorry, but no less/sass used for any of the template. Just plain css/js is there
Hello imithemes…downloaded your template can't seem to get the sticky header to work and the slider.
Please i need help with this ASAP
Hi there
Please create a new support thread here: http://support.imithemes.com/forums/forum/html-templates/native-church/#new-post with your website URL and problems and my team would be happy to assist you.
Could you give me some advice, how should I implement this theme on a CMS with MVC pattern?
Thank you
Hi there
This is a HTML5 template which you can use to develop any CMS site but you should have knowledge about the CMS theme/template development. Sorry, but i can not help much on this.
Sir, I have sent you my problem via your customer support. I real need your help thank you
Hi, please send me the thread URL you have created for your problem. Thanks
Quit question.
I have a project to 80% using the previous version of the template. Now with the update that included. What files (js, css, jquery, etc. etc.) would have to update? for the benefit of the update and that my project is not affected.
Thanks for your support.
Please refer to below comment: http://themeforest.net/item/nativechurch-responsive-html5-template/7010838/comments?page=4&filter=all#comment_10305597
New version 1.5 Changed Files
Edited Files:
- style.css (css folder) - prettyphoto.js (plugins/prettyphoto/js folder) - All HTML pages (Just to add new menu items) - contact.php (mail folder) - All color css files (colors folder) - font-awesome.css (css folder) - fonts folder (css folder)
New Files/Folders:
- rs-plugin folder (plugins folder) - extralayers.css (css folder) - navstylechange.css (css folder) - index-rev-slider.html, shop.html, shop-sidebar.html, shop-product.html
For more questions and concerns about the changed files and this update, please create a support thread here: http://support.imithemes.com/forums/forum/html-templates/native-church/#new-post
Cheers imithemes
When will the updates to the WordPress version be ported to this version of NativeChurch? Or all of the change log entries WordPress-specific?
Hi there
As NativeChurch HTML and WP are 2 different products so the update plans are different for both as required and suggested by our users.
If you support RTL (Right-To-Left)
Hi there
Yes Template comes with RTL support
This is a very nice church themed template. I notice there is a "search posts" field on home version 4. Does that search the entire site? Can it be placed on multiple pages and anywhere on the page? The reason I'm asking is that I really need the search function to be able to search the sermon archives section. I'm new to responsive layout. I use dreamweaver cs4 to edit css and html
Hi there
As this is a HTML template so the search is not functioning. You can surely edit it using the Dreamweaver. But if you need a full functional search form and all then you can consider buying its WordPress version: http://themeforest.net/item/nativechurch-multi-purpose-wordpress-theme/7082446
Pls I want to buy the theme can you upload it for?
Hi there
This is a HTML template, you might be interested in its WP version: http://themeforest.net/item/nativechurch-multi-purpose-wordpress-theme/7082446 All installation documentation comes with the theme and you can always ask for help about it on our support forum.


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Planetwise Equine Fresh Pellet Bedding 40lb-EQUINE FRESH 4$5.49
Product Description
- Easier than Shavings
- Cuts Stall Cleaning Time
- Dust Free, Mold, Bacteria & Insect Resistant
- Longer Lasting & more Cost Effective than other Horse Bedding
- Reduces Waste - Making Optimal Compost Available in 40 lb. Bags
Durvet Duramycin-10 Antibiotic Soluble Powder for Livestock 6.4oz$4.99
For use in drinking water for swine, calves and poultry.Learn More
Purina Dobbin's Delights Apple & Oat Crunchy Horse Treats 3.5 Lb. 26183$6.99
- Puffy, lightly textured biscuits
- Nutritious & packed with vitamins & minerals
- Excellent size & unique shape
- Highly palatable
- No added colors
- Contains real apple
- Made with wholesome ingredients
- For adult horses
- Resealable container
- Made in the USA
- Weight: Approximately 4 pounds
- Dimensions: Approximately 11 x 8 x 6 in
Miller Mfg. 32 oz. Rabbit Water Bottle OPB32$4.99
Economy priced water bottles are constructed from strong, opaque plastic with colorful graphics. Stainless steel ballpoint tube keeps water clean and cage dry. Perfect for rabbits, guinea pigs, ferrets, and other small animals.Learn More
Little Giant 5" Sifter Feeder with Lid AF5SL$6.49
Product Features
- Built to last
- Chew & Rust Resistant
- Convenient to fill from outside hutch
- Card holder for feeding records
Purina Dobbins Delights Carrot & Oat Crunchy Horse Cookie Treats 2.5 lb. 3003258-746$6.99
- Puffy, lightly textured biscuits
- Nutritious & packed with vitamins & minerals
- Excellent size & unique shape
- Highly palatable
- No added colors
- Contains real apple
- Made with wholesome ingredients
- For adult horses
- Resealable container
- Made in the USA
- Weight: Approximately 4 pounds
- Dimensions: Approximately 11 x 8 x 6 in
- Contains real carrot
250 watt Red Faced Heat Lamp Bulb 905075$5.99
- Red
- 5000 hours
- 250 watt
Harvest Lane Honey 1 lb. Pollen Pattie PP10-101$4.99
- Pollen Pattie contains 4% Pollen.
- Stimulates growth and production.
- Feed in the Spring, Fall and Winter.
- Great for new packages of bees. Contains 4% Pollen.
- Used to stimulate and feed new and existing hives, can be place directly onto the frames, remove 1st outer plastic before placement.
Miller Mfg. 12" Galvanized Slide-Top Poultry Chicken Feeder 9814$4.49
Individual holes minimize waste. Top slides off for easy access. Made of heavy gauge galvanized steel and feature rolled edges for safety.Learn More
Kaytee Aspen Bedding & Litter 1200 Cu. In. 100032002$4.99
Kaytee Aspen Bedding & Litter is manufactured with all natural aspen shavings specially processed to eliminate dust and wood debris found in other bedding. Aspen bedding comes from hardwood, eliminating aromatic oils found in other types of wood bedding. *Can be used in all cages, aquariums and habitrails. *A natural biodegradable product.
Ingredients: Kiln dried aspen shavings.
- 20 liter package
- 1200 cubic inches
When you have livestock, there are so many items that you need just to care for them. They need proper food and feeding equipment. When they are sick, they need the proper medicine. Even when they aren't sick, you need to provide preventative medicine. Animals also need proper housing. There is just so much to think about. That is why our livestock category is so comprehensive.
Let's say you have rabbits. You will need the proper style cage, a drop pan to put at the bottom and bedding so your rabbits are safely housed. The last thing you want is a loose rabbit. There is too much danger out there for them to be running free. You'll also need the proper supplies to feed them, like hay and pellet food.
What if rabbits aren't your thing? How about if you are more into bees? Well, we can help you with that, too. We have frames and boxes. There are also entrance reducers and queen excluders, if you need them.
It really doesn't matter what type of livestock you have, from bees and rabbits to cows and chickens and even dogs and potbellied pigs, we have something for them all. This category offers a range of items that you will need to properly care for any animal you have.


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In Store Only:Please check Store stock for local availability
A compact, indoor digital active (amplified) TV antenna that covers all Australian UHF and VHF channels, with a soft blue indicator light set against a metallic grey casing.
Spot a Mistake? Talk to us about any inaccuracies or errors. Click here.
Have your purchase delivered to your door from as little as $9.95. Once dispatched your order can be tracked so you'll know where it is and when it will arrive.
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text:
- Combustion Air Kit
- Flex Provides an avenue for combustion air to flow from the Pellet Stove Adapter to the combustion air inlet of the appliance
- Kit includes: 3 feet of 3" ID aluminum and one hose clamp. Clamp adjusts from 1-1/2" to 3-1/2" to fit all pellet and corn stoves.
Additional Metalbest Links
This Metalbest item can also be referenced by the following color/finish specific model #:
- Metalbest 1604614
*Discontinued model or finish
More Than Just a Store - Your Reasons to Shop
Discover the best online deals for the 4DT-CAK and everything else for your home from the leading online home improvement store.
We're committed to providing you with the best assortment of Metalbest products with over 400 warehouses across the country.
Our knowledgeable product specialists work to bring you the best prices on every product and provide unmatched customer service. Your satisfaction is our highest priority!
Installation Resource Center
Whether you are installing the product yourself or hiring a professional, our installation Resource Center has everything you need to get your project done. Visit the Installation Resource Center to get started.


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About Deep In The South Primtiques
Our Service PledgeWe will gladly respond to orders and questions within 12 hours and do our very best to give an accurate description of all our items.
About UsMy husband has been making primitive folk art for over 20 years. He began after retiring from the Navy after 22 years of service.
I enjoy the antique end of things so when he is not in his shop, we are most likely out and about looking at neat old stuff to offer. Anything that I offer is such that I would be willing to display in my home as well. In fact, sometimes it is difficult to give up some of our finds but there is only so much room in a home. :) We offer a wide range of items and you just never know what will show up.
Please always feel free to email with any questions you may have!
Lorie Sims
3800 Youngs Mill Road
Lineville, AL
Tel: (256) 322-1207
View Location
Lineville, AL
Tel: (256) 322-1207
View Location
Email Shop


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A True Story Starring You
When You Were One
A True Story Starring You
1. Paste a photo of your baby's smiling face on the inside back cover.
2. Use a permanent marker to record major milestones during your baby's second year, from the first birthday to the second birthday.
Just think how much fun it will be to read this delightful journal when your baby is three, four, five, or when your "baby" gets married and has children of his or her own.
- Meadowbrook |
- 10 pages |
- November 2000


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Posts Tagged 'Kimberly Einmo'
FIRE AND ICE Wins Best Modern Quilt at Chattanooga
Kimberly Einmo's quilt, FIRE AND ICE, won Best Modern Quilt at AQS QuiltWeek® – Chattanooga, Tennessee 2014. MORE GREAT NEWS: We're pleased to announce that the FIRE AND ICE pattern is coming soon to ShopAQS! Watch as Kimberly explains a little about the [Read More]
Free Pattern: TRAIL TO PADUCAH
This year's QuiltWeek event in Paducah was a delightful experience and is now a sweet memory! We were so happy to see all who attended. Here's a THANK YOU treat! Enjoy this free quilt pattern, TRAIL TO PADUCAH, which will finish at about 79″ x 79″. [Read More]
Meet Kimberly Einmo
Kimberly Einmo is an author, award-winning quilter, designer, international instructor, and quilt judge. She has written five books published by the American Quilter's Society including her newest, Modern Quilts & More, plus Jelly Roll Quilts & More, Jelly Roll [Read More]
FIRE AND ICE is Viewer's Choice
Introducing FIRE & ICE, Viewer's Choice winner at AQS QuiltWeek® – Des Moines, Iowa 2013. AQS Author, Kimberly Einmo, designed and sewed this quilt using Aurifil Quilt Patchwork and Embroidery Threads. Judi Madsen, of Green Fairy Quilts, provided exquisite [Read More]
Kimberly Einmo on the Radio with Pat Sloan
Tune in to Pat Sloan – The Voice of Quilting on October 1, 2012, at 4 pm EDT when her featured guest will be AQS author Kimberly Einmo. Pat and Kimberly will be chatting about quilt judging and Kimberly's newest release Precut Bonanza! 200 Pieced Blocks from [Read More]
Texas Quilt Shop Wins Kimberly Einmo
Yes, the Cabbage Rose quilt shop in Fort Worth, Texas, has won Kimberly Einmo. But, they only get to keep her for ONE DAY. AQS sponsored a contest for quilt shops who attended the Houston Quilt Market last year. The prize was a visit from author, teacher, and designer [Read More]
Free – Fractured Light Pattern by Kimberly Einmo
Kimberly Einmo loves to doodle with her mouse while using Electric Quilt 7, her favorite quilt design software. With nothing more than a vague idea in mind, the click of the mouse conjures up all sorts of potential designs. While playing with the traditional T block on [Read More]
Precut Bonanza by Kimberly Einmo
Precut Bonanza 200 Pieced Block From Cut Strips & Shapes by Kimberly Einmo Precut Bonanza is the ultimate go-to guide for using precut fabrics in pieced blocks! Welcome to Kimberly's wonderful world of Modular Quilting. Follow her method of using simple units to [Read More]
AQS Releases from Einmo & Woodworth
Now available from AQS Publishing, two books that are a must for any quilter's library: Precut Bonanza: 200 Pieced Blocks from Cut Strips & Shapes by Kimberly Einmo This is the ultimate guide for using precut fabrics in pieced blocks! Follow [Read More]
Kimberly Einmo — Jelly Roll Quilt Magic
Kimberly Einmo tells us about her AQS book Jelly Roll Quilt Magic. Click to order Jelly Roll Quilt Magic Click to order Jelly Roll Quilts & More Click to order Quilt a Travel Souvenir About Kimberly Einmo [Read More]


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This question falls squarely on the shoulders of Mr. Stanley E. Kroenke. http://i189.photobucket.com/albums/z...e_1568752c.jpg
His first order of business for turning this around must be blowing the whole thing up. Billy is inadequate at bringing in talent at the level thats needed to be competitive in the NFL, and Spags (who I think is an incredible defensive mind), is not ready to lead a team of 53 any time soon.
Now that Stan has blown things up to put his stamp on the team here is what he must do:
The man cannot be cheap. This head coaching search is going to be competitive, with many teams searching for a new leader, and all going for the big names. Him and his wife are worth a COMBINED 7 BILLION dollars. Yes, you read that right. Not some made up number bajillion, they are worth 7 billion dollars. He needs to get Jon Gruden, Jeff Fisher, and Bill Cowher on the phone. He needs to say to them all "Do you have any interest in returning to coaching?" In regards to Cowher and Gruden, he must play to their egos. Every coach loves being the first to do something big. There is one achievement that has yet to be attained that I am sure is in the back of many SB Head Coaches that aren't coaching now. No coach in the history of the NFL has ever won a Super Bowl with two different teams. Stan must tell them he thinks they have what it takes to be the first to do this. So long as one of the three of them say yes, he should call them in for an interview and during that interview throw a blank check on the table and say "Write down the number, and you're hired." The man has the money to not be stingy, and its going to take $ to lure a big name here to clean up this mess. I think Gruden and Cowher are available for the right price.
Now that we have successfully secured a big prize of a former head coach, he will allow the head coach to hire the GM, unconventional, but smart. GM-HC relationship is a bond. They must be close, and not have resentment i.e Pioli and Haley. Now that the Head Coach has succesfully secured someone that he trusts to be his GM, Stan will hand a few more blank checks to our hired head coach. He will say "Heres some more money for the rest of the staff. Go compile the best staff in the NFL."
Now let the Staff and management go to work...results will show.
So to get to the initial topic of this post, I think if the Rams bring in the right coaches we can turn it around as soon as next season. We won 7 games last year in spite of coaching, and are much better than 2 wins this season. I think two years is the max it would take to turn this around with the right people.
While I will support us bringing in a hot coordinator i.e. Chudzinski or anyone to replace Spags, Stan cannot go cheap. Our future depends on his ability to use the riches that he has attained throughout his life to bring in someone with $$$$$. It will take longer to see results if we go this route, and I want results ASAP.
January 2nd we will find out a lot about Mr. Stanley E. Kroenke. We will find out whether he truly wants to fix this, or if he has another agenda and doesn't care about the Rams or attendance. My guess is, given his competitive background, he's going to do whatever it takes to get this turned around ASAP. If changes aren't made, next season is going to be a long, miserable season as usual.
Ultimately, one of these three men are the key to turning it around at Rams Park:
http://i189.photobucket.com/albums/z...eff-Fisher.jpg http://i189.photobucket.com/albums/z...illcowher1.jpg http://i189.photobucket.com/albums/z...enFace2005.jpg


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Benedetti–Wehrli Stadium
|This article does not cite any sources. (April 2015)
Benedetti–Wehrli Stadium is a stadium in Naperville, Illinois. It is primary used for American football and soccer. The stadium hosted the 2000 NCAA Division III Men's Outdoor Track and Field Championship. The stadium opened in 1999 for North Central College and was used by the Chicago Fire in 2002 and 2003, when it was known as Cardinal Stadium. Benedetti–Wehrli Stadium is named after two North Central College Alumni/Donors: Albert Benedetti and Richard Wehrli. Benedetti-Wehrli also hosts the two highly hyped football games of Naperville Central High School - Naperville North High School and Waubonsie Valley High School-Neuqua Valley High School. The stadium also serves as host to a competitive drum corps show hosted by The Cavaliers Drum and Bugle Corps of Rosemont, Ill., each summer. The stadium has a capacity of 5,500. The stadium served as a venue for the quarter finals of the 2000 Lamar Hunt U.S. Open Cup.
|Preceded by
Soldier Field
|Home of the Chicago Fire
2002 – 2003
|Succeeded by
Soldier Field
Coordinates: 41°46′10″N 88°08′45″W / 41.769513°N 88.145938°W
|This article about a sports venue in Illinois is a stub. You can help Wikipedia by expanding it.


text: A rectangular loop of N close-packed turns is positioned near a long straight wire as in the figure. What is the formula for the mutual inductance M for the loop-wire combination? Evaluate M for N = 90, a = 1.0 cm, b = 9.0 cm and l = 40.0 cm.


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Genesis 41:8-14New International Version (NIV)
8 In the morning his mind was troubled, so he sent for all the magicians and wise men of Egypt. Pharaoh told them his dreams, but no one could interpret them for him.
9 Then the chief cupbearer said to Pharaoh, "Today I am reminded of my shortcomings. 10 Pharaoh was once angry with his servants, and he imprisoned me and the chief baker in the house of the captain of the guard. 11 Each of us had a dream the same night, and each dream had a meaning of its own. 12 Now a young Hebrew was there with us, a servant of the captain of the guard. We told him our dreams, and he interpreted them for us, giving each man the interpretation of his dream. 13 And things turned out exactly as he interpreted them to us: I was restored to my position, and the other man was impaled."
14 So Pharaoh sent for Joseph, and he was quickly brought from the dungeon. When he had shaved and changed his clothes, he came before Pharaoh.
Cross references:
New International Version (NIV)
Holy Bible, New International Version®, NIV® Copyright ©1973, 1978, 1984, 2011 by Biblica, Inc.® Used by permission. All rights reserved worldwide.
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Are you Na Li?Claim your profile
Publications (2)8.87 Total impact
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ABSTRACT: Chemically synthesized small interfering RNAs (siRNAs) have been widely used to identify gene function and hold great potential in providing a new class of therapeutics. Chemical modifications are desired for therapeutic applications to improve siRNA efficacy. Appropriately protected ribonucleoside-3'-yl S-[β-(benzoylmercapto)ethyl]pyrrolidino-thiophosphoramidite monomers were prepared for the synthesis of siRNA containing phosphorodithioate (PS2) substitutions in which the two non-bridging oxygen atoms are replaced by sulfur atoms. A series of siRNAs containing PS2 substitutions have been strategically designed, synthesized, and evaluated for their gene silencing activities. These PS2-siRNA duplexes exhibit an A-form helical structure similar to unmodified siRNA. The effect of PS2 substitutions on gene silencing activity is position-dependent, with certain PS2-siRNAs showing activity significantly higher than that of unmodified siRNA. The relative gene silencing activities of siRNAs containing either PS2 or phosphoromonothioate (PS) linkages at identical positions are variable and depend on the sites of modification. 5'-Phosphorylation of PS2-siRNAs has little or no effect on gene silencing activity. Incorporation of PS2 substitutions into siRNA duplexes increases their serum stability. These results offer preliminary evidence of the potential value of PS2-modified siRNAs.
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ABSTRACT: Therapeutic aptamers are synthetic, structured oligonucleotides that bind to a very broad range of targets with high affinity and specificity. They are an emerging class of targeting ligand that show great promise for treating a number of diseases. A series of aptamers currently in various stages of clinical development highlights the potential of aptamers for therapeutic applications. This review covers in vitro selection of oligonucleotide ligands, called aptamers, from a combinatorial library using the Systematic Evolution of Ligands by Exponential Enrichment process as well as the other known strategies for finding aptamers against various targets. Readers will gain an understanding of the highly useful strategies for successful aptamer discovery. They may also be able to combine two or more of the presented strategies for their aptamer discovery projects. Although many processes are available for discovering aptamers, it is not easy to discover an aptamer candidate that is ready to move toward pharmaceutical drug development. It is also apparent that there have been relatively few therapeutic advances and clinical trials undertaken due to the small number of companies that participate in aptamer development.


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A star-studded guest list doesn't always guarantee a great party. If, for example, that party included Jackson Browne, the Jayhawks, David Crosby, Graham Nash, Heartbreakers Mike Campbell and Benmont Tench, Father John Misty, Wilco's Pat Sansone... you'd likely wonder whether and where you'd ever actually find the host. And what sort would he be?
This is Jonathan Wilson's party, and, fortunately, you'll find him front and center on Fanfare, his second album. It's an epic love poem to '70s California rock. In lesser hands, guests like Browne, Crosby, and Nash would be included merely to reprise their younger days, or add some gray-haired "authenticity" to the proceedings.
But Fanfare is entirely Wilson's creation. The guest list is a roster of folks who created that sound the first time around, and hear something in Wilson's music that reminds them why they do what they do. Sure, at times the guitar solos go too long and the whole things screams of studio excess. But if Wilson was looking for some authenticity, he could hardly have done better than to build on the excesses of the signature sound in question.
I disagree about the "studio excess" comment. It may be that we're so used to listening to bedroom recordings, that we've forgotten what it sounds like when someone who really knows what they're doing gets into a studio. My further thoughts are here: http://anearful.blogspot.com/2013/12/ambition-not-four-letter-word.html.
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Are you Katerina Vaporidi?Claim your profile
Publications (22)98.61 Total impact
Article: ASSESSMENT OF RESPIRATORY MECHANICS AND RESPIRATORY MUSCLES OF DIFFICULT TO WEAN CRITICALLY ILL PATIENTS
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ABSTRACT: AEGLE project targets to build an innovative ICT solution addressing the whole data value chain for health based on: cloud computing enabling dynamic resource allocation, HPC infrastructures for computational acceleration and advanced visualization techniques. In this paper, we provide an analysis of the addressed Big Data health scenarios and we describe the key enabling technologies, as well as data privacy and regulatory issues to be integrated into AEGLE's ecosystem, enabling advanced health-care analytic services, while also promoting related research activities.
Article: Genetic and pharmacologic inhibition of Tpl2 kinase is protective in a mouse model of ventilator-induced lung injury[Show abstract] [Hide abstract]
ABSTRACT: Mechanical stress induced by injurious ventilation leads to pro-inflammatory cytokine production and lung injury. The extracellular-signal-regulated-kinase, ERK1/2, participates in the signaling pathways activated upon mechanical stress in the lungs to promote the inflammatory response. Tumor progression locus 2 (Tpl2) is a MAP3kinase that activates ERK1/2 upon cytokine or TLR signaling, to induce pro-inflammatory cytokine production. The role of Tpl2 in lung inflammation, and specifically in the one caused by mechanical stress has not been investigated. The aim of the study was to examine if genetic or pharmacologic inhibition of Tpl2 could ameliorate ventilator-induced lung injury. Adult male wild-type and Tpl2-deficient mice were ventilated with normal or high tidal volume for 4 h. Additional wild-type mice were treated with a Tpl2 inhibitor either before or 30 min after initiation of high tidal ventilation. Non-ventilated mice of both genotypes served as controls. The development of lung injury was evaluated by measuring lung mechanics, arterial blood gases, concentrations of proteins, IL-6, and MIP-2 in bronchoalveolar lavage fluid (BALF) and by lung histology. Data were compared by Kruskal-Wallis non-parametric test and significance was defined as p < 0.05. Mechanical ventilation with normal tidal volume induced a mild increase of IL-6 in BALF in both strains. High tidal volume ventilation induced lung injury in wild-type mice, characterized by decreased lung compliance, increased concentrations of proteins, IL-6 and MIP-2 in BALF, and inflammatory cell infiltration on histology. All indices of lung injury were ameliorated in Tpl2-deficient mice. Wild-type mice treated with the Tpl2 inhibitor, either prior of after the initiation of high tidal volume ventilation were protected from the development of lung injury, as indicated by preserved lung compliance and lower BALF concentrations of proteins and IL-6, than similarly ventilated, untreated wild-type mice. Genetic and pharmacologic inhibition of Tpl2 is protective in a mouse model of ventilator-induced lung injury, ameliorating both high-permeability pulmonary edema and lung inflammation.
Article: Akt2 Deficiency Protects from Acute Lung Injury via Alternative Macrophage Activation and miR-146a Induction in Mice[Show abstract] [Hide abstract]
ABSTRACT: Acute respiratory distress syndrome (ARDS) is a major cause of respiratory failure, with limited effective treatments available. Alveolar macrophages participate in the pathogenesis of ARDS. To investigate the role of macrophage activation in aseptic lung injury and identify molecular mediators with therapeutic potential, lung injury was induced in wild-type (WT) and Akt2(-/-) mice by hydrochloric acid aspiration. Acid-induced lung injury in WT mice was characterized by decreased lung compliance and increased protein and cytokine concentration in bronchoalveolar lavage fluid. Alveolar macrophages acquired a classical activation (M1) phenotype. Acid-induced lung injury was less severe in Akt2(-/-) mice compared with WT mice. Alveolar macrophages from acid-injured Akt2(-/-) mice demonstrated the alternative activation phenotype (M2). Although M2 polarization suppressed aseptic lung injury, it resulted in increased lung bacterial load when Akt2(-/-) mice were infected with Pseudomonas aeruginosa. miR-146a, an anti-inflammatory microRNA targeting TLR4 signaling, was induced during the late phase of lung injury in WT mice, whereas it was increased early in Akt2(-/-) mice. Indeed, miR-146a overexpression in WT macrophages suppressed LPS-induced inducible NO synthase (iNOS) and promoted M2 polarization, whereas miR-146a inhibition in Akt2(-/-) macrophages restored iNOS expression. Furthermore, miR-146a delivery or Akt2 silencing in WT mice exposed to acid resulted in suppression of iNOS in alveolar macrophages. In conclusion, Akt2 suppression and miR-146a induction promote the M2 macrophage phenotype, resulting in amelioration of acid-induced lung injury. In vivo modulation of macrophage phenotype through Akt2 or miR-146a could provide a potential therapeutic approach for aseptic ARDS; however, it may be deleterious in septic ARDS because of impaired bacterial clearance.
Conference Paper: AKT2 DEFICIENCY AND ALTERNATIVE ACTIVATION OF MACROPHAGES PROTECTS FROM ACID-ASPIRATION INDUCED ARDS VIA INDUCTION OF MIR-146A
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ABSTRACT: The aim of this study was to investigate the changes induced by high tidal volume ventilation (HVTV) in pulmonary expression of micro-RNAs (miRNAs) and identify potential target genes and corresponding miRNA-gene networks. Using a real-time RT-PCR-based array in RNA samples from lungs of mice subjected to HVTV for 1 or 4 h and control mice, we identified 65 miRNAs whose expression changed more than twofold upon HVTV. An inflammatory and a TGF-β-signaling miRNA-gene network were identified by in silico pathway analysis being at highest statistical significance (P = 10(-43) and P = 10(-28), respectively). In the inflammatory network, IL-6 and SOCS-1, regulated by miRNAs let-7 and miR-155, respectively, appeared as central nodes. In TGF-β-signaling network, SMAD-4, regulated by miR-146, appeared as a central node. The contribution of miRNAs to the development of lung injury was evaluated in mice subjected to HVTV treated with a precursor or antagonist of miR-21, a miRNA highly upregulated by HVTV. Lung compliance was preserved only in mice treated with anti-miR-21 but not in mice treated with pre-miR-21 or negative-control miRNA. Both alveolar-arterial oxygen difference and protein levels in bronchoalveolar lavage were lower in mice treated with anti-miR-21 than in mice treated with pre-miR-21 or negative-control miRNA (D(A-a): 66 ± 27 vs. 131 ± 22, 144 ± 10 mmHg, respectively, P < 0.001; protein concentration: 1.1 ± 0.2 vs. 2.3 ± 1, 2.1 ± 0.4 mg/ml, respectively, P < 0.01). Our results show that HVTV induces changes in miRNA expression in mouse lungs. Modulation of miRNA expression can affect the development of HVTV-induced lung injury.
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ABSTRACT: Activated macrophages are described as classically activated or M1 type and alternatively activated or M2 type, depending on their response to proinflammatory stimuli and the expression of genetic markers including iNOS, arginase1, Ym1, and Fizz1. Here we report that Akt kinases differentially contribute to macrophage polarization, with Akt1 ablation giving rise to an M1 and Akt2 ablation resulting in an M2 phenotype. Accordingly, Akt2(-/-) mice were more resistant to LPS-induced endotoxin shock and to dextran sulfate sodium (DSS)-induced colitis than wild-type mice, whereas Akt1(-/-) mice were more sensitive. Cell depletion and reconstitution experiments in a DSS-induced colitis model confirmed that the effect was macrophage-dependent. Gene-silencing studies showed that the M2 phenotype of Akt2(-/-) macrophages was cell autonomous. The microRNA miR-155, whose expression was repressed in naive and in LPS-stimulated Akt2(-/-) macrophages, and its target C/EBPβ appear to play a key role in this process. C/EBPβ, a hallmark of M2 macrophages that regulates Arg1, was up-regulated upon Akt2 ablation or silencing. Overexpression or silencing of miR-155 confirmed its central role in Akt isoform-dependent M1/M2 polarization of macrophages.
Article: Protective and Detrimental Effects of Sodium Sulfide and Hydrogen Sulfide in Murine Ventilator-induced Lung Injury[Show abstract] [Hide abstract]
ABSTRACT: The antiinflammatory effects of hydrogen sulfide (H2S) and sodium sulfide (Na2S) treatment may prevent acute lung injury induced by high tidal volume (HVT) ventilation. However, lung protection may be limited by direct pulmonary toxicity associated with H2S inhalation. Therefore, the authors tested whether the inhalation of H2S or intravascular Na2S treatment can protect against ventilator-induced lung injury in mice. Anesthetized mice continuously inhaled 0, 1, 5, or 60 ppm H2S or received a single bolus infusion of Na2S (0.55 mg/kg) or vehicle and were then subjected to HVT (40 ml/kg) ventilation lasting 4 h (n = 4-8 per group). HVT ventilation increased the concentrations of protein and interleukin-6 in bronchoalveolar lavage fluid, contributing to reduced respiratory compliance and impaired arterial oxygenation, and caused death from lung injury and pulmonary edema. Inhalation of 1 or 5 ppm H2S during HVT ventilation did not alter lung injury, but inhalation of 60 ppm H2S accelerated the development of ventilator-induced lung injury and enhanced the pulmonary expression of the chemoattractant CXCL-2 and the leukocyte adhesion molecules CD11b and L-selectin. In contrast, pretreatment with Na2S attenuated the expression of CXCL-2 and CD11b during HVT ventilation and reduced pulmonary edema. Moreover, Na2S enhanced the pulmonary expression of Nrf2-dependent antioxidant genes (NQO1, GPX2, and GST-A4) and prevented oxidative stress-induced depletion of glutathione in lung tissue. The data suggest that systemic intravascular treatment with Na2S represents a novel therapeutic strategy to prevent both ventilator-induced lung injury and pulmonary glutathione depletion by activating Nrf2-dependent antioxidant gene transcription.
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ABSTRACT: To compare the diagnostic performance of lung ultrasound and bedside chest radiography (CXR) for the detection of various pathologic abnormalities in unselected critically ill patients, using thoracic computed tomography (CT) as a gold standard. Forty-two mechanically ventilated patients scheduled for CT were prospectively studied with a modified lung ultrasound protocol. Four pathologic entities were evaluated: consolidation, interstitial syndrome, pneumothorax, and pleural effusion. Each hemithorax was evaluated for the presence or absence of each abnormality. Eighty-four hemithoraces were evaluated by the three imaging techniques. The sensitivity, specificity, and diagnostic accuracy of CXR were 38, 89, and 49% for consolidation, 46, 80, and 58% for interstitial syndrome, 0, 99, and 89% for pneumothorax, and 65, 81, and 69% for pleural effusion, respectively. The corresponding values for lung ultrasound were 100, 78, and 95% for consolidation, 94, 93, and 94% for interstitial syndrome, 75, 93, and 92% for pneumothorax, and 100, 100, and 100% for pleural effusion, respectively. The relatively low sensitivity of lung ultrasound for pneumothorax could be due to small number of cases (n = 8) and/or suboptimal methodology. In our unselected general ICU population lung ultrasound has a considerably better diagnostic performance than CXR for the diagnosis of common pathologic conditions and may be used as an alternative to thoracic CT.
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ABSTRACT: In mechanically ventilated patients with COPD, the response of the expiratory resistance of the respiratory system (expiratory R(RS)) to bronchodilators is virtually unknown. To examine the effect of inhaled albuterol on expiratory R(RS), and the correlation of albuterol-induced changes in expiratory R(RS) with end-inspiratory resistance and the expiratory flow-volume relationship. We studied 10 mechanically ventilated patients with COPD exacerbation, before and 30 min after administration of albuterol. We obtained flow-volume curves during passive expiration, divided the expired volume into 5 equal volume slices, and then calculated the time constant and dynamic effective deflation compliance of the respiratory system (effective deflation C(RS)) of each slice via regression analysis of the volume-flow and post-occlusion volume-tracheal pressure relationships, respectively. For each slice we calculated expiratory R(RS) as the time constant divided by the effective deflation C(RS). Albuterol significantly decreased the expiratory R(RS) (mean expiratory R(RS) 42.68 ± 17.8 cm H(2)O/L/s vs 38.08 ± 16.1 cm H(2)O/L/s) and increased the rate of lung emptying toward the end of expiration (mean time constant 2.51 ± 1.2 s vs 2.21 ± 1.2 s). No correlation was found between the albuterol-induced changes in expiratory R(RS) and that of end-inspiratory resistance. Only at the end of expiration did albuterol-induced changes in the expiratory flow-volume relationship correlate with changes in expiratory R(RS) in all patients. In patients with COPD, albuterol significantly decreases expiratory resistance at the end of expiration. In mechanically ventilated patients, neither inspiratory resistance nor the whole expiratory flow-volume curve may be used to evaluate the bronchodilator response of expiratory resistance.
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ABSTRACT: Respiratory muscle dysfunction is a cardinal feature of acute and chronic respiratory failure in COPD. Diaphragm and accessory inspiratory muscles face increased load due to increased lung resistance and elastance, as well as increased ventilatory demands. Concomitantly, the capacity of the inspiratory muscles to generate pressure is decreased due to mechanical disadvantage imposed by hyperinflation. Additionally, inflammation and oxidative stress impair muscle fiber specific force generation and increase diaphragm susceptibility to sarcomer disruption during acute inspiratory loading. In response to this increased load diaphragm presents unique adaptations in its cellular structure and passive and contractile mechanical properties, and displays a more efficient metabolic armamentarium. A shift of muscle fiber type towards slow-twitch, oxidative type I fibers, which are more fatigue-resistant, increases diaphragmatic endurance but protein degradation and a significant reduction in myosin content decrease its force generating capacity. Furthermore, diaphragm adapts to chronic hyperinflation by sarcomere deletion so that its overall length is shortened, in an attempt to preserve optimum force-length relationship. Adaptation however may not be complete, or may be overwhelmed by pathophysiologic derangements during exercise or acute exacerbations, leading to obvious "dysfunction" of the respiratory muscles, and if sustained, ultimately to muscle fatigue and respiratory pump failure.
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ABSTRACT: Nitric oxide synthase (NOS) depletion or inhibition reduces ventilator-induced lung injury (VILI), but the responsible mechanisms remain incompletely defined. The aim of this study was to elucidate the role of endothelial NOS, NOS3, in the pathogenesis of VILI in an in vivo mouse model. Wild-type and NOS3-deficient mice were ventilated with high-tidal volume (HV(T); 40 ml/kg) for 4 h, with and without adding NO to the inhaled gas. Additional wild-type mice were pretreated with tetrahydrobiopterin and ascorbic acid, agents that can prevent NOS-generated superoxide production. Arterial blood gas tensions, histology, and lung mechanics were evaluated after 4 h of HV(T) ventilation. The concentration of protein, IgM, cytokines, malondialdehyde, and 8-isoprostane were measured in bronchoalveolar lavage fluid (BALF). Myeloperoxidase activity, total and oxidized glutathione levels, and NOS-derived superoxide production were measured in lung tissue homogenates. HV(T) ventilation induced VILI in wild-type mice, as reflected by decreased lung compliance, increased concentrations of protein and cytokines in BALF, and oxidative stress. All indices of VILI were ameliorated in NOS3-deficient mice. Augmenting pulmonary NO levels by breathing NO during mechanical ventilation did not increase lung injury in NOS3-deficient mice. HV(T) ventilation increased NOS-inhibitable superoxide production in lung extracts from wild-type mice but not in those from NOS3-deficient mice. Administration of tetrahydrobiopterin and ascorbic acid ameliorated VILI in wild-type mice. Our results indicate that NOS3 contributes to ventilator-induced lung injury via increased production of superoxide.
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ABSTRACT: Recently, a new technology has been introduced aiming to monitor and improve patient ventilator interaction (PVI monitor). With the PVI monitor, a signal representing an estimation of the patient's total inspiratory muscle pressure (Pmus(PVI)) is calculated from the equation of motion, utilizing estimated values of resistance and elastance of the respiratory system. The aim of the study was to prospectively examine the accuracy of Pmus(PVI) to quantify inspiratory muscle pressure. Eleven critically ill patients mechanically ventilated on proportional assist ventilation with load-adjustable gain factors were studied at three levels of assist (30, 50 and 70%). Airway, esophageal, gastric and transdiaphragmatic (Pdi) pressures, volume and flow were measured breath by breath, whereas the total inspiratory muscle pressure (Pmus) was calculated using the Campbell diagram. For a given assist, Pmus(PVI) throughout inspiration did not differ from the corresponding values calculated using the Pdi and Pmus signals. Inspiratory and expiratory time did not differ among the various methods of calculation. Inspiratory muscle pressure decreased with increasing assist, and the magnitude of this decrease did not differ among the various methods of pressure calculation. A signal generated from flow, volume and airway pressure may be used to provide breath-by-breath quantitative information of inspiratory muscle pressure.
Conference Paper: Endothelial Nitric Oxide (NO) Synthase (NOS3) Contributes to Ventilator-Induced Lung Injury (VILI).
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ABSTRACT: Clinical studies using both polysomnographic data and patient's perception have shown a poor quality of sleep among mechanically ventilated patients, which may have cardiorespiratory, neurological, immunological and metabolic consequences. Pre-existing medical or chronic sleep disorders, severity of illness, the acute illness that precipitated the ICU admission, the ICU environment, alterations in circadian rhythm, sedatives and mechanical ventilation per. se may be causes of poor sleep in these patients. Mechanical ventilation can disrupt sleep either by producing periodic breathing and central apnoeas or by promoting patient-ventilator dysynchrony. Excessive assist during ventilation on conventional modes may lead to the development of central apnoeas by decreasing PaC02, the main determinant that controls breathing during sleep or sedation. New modes of assisted mechanical ventilation that promote the synchrony between the patient and ventilator have been introduced and may reduce sleep disruption.
Article: Proportional assist ventilation with load-adjustable gain factors in critically ill patients: Comparison with pressure support[Show abstract] [Hide abstract]
ABSTRACT: It is not known if proportional assist ventilation with load-adjustable gain factors (PAV+) may be used as a mode of support in critically ill patients. The aim of this study was to examine the effectiveness of sustained use of PAV+ in critically ill patients and compare it with pressure support ventilation (PS). Randomized study in the intensive care unit of a university hospital. A total of 208 critically ill patients mechanically ventilated on controlled modes for at least 36 h and meeting certain criteria were randomized to receive either PS (n = 100) or PAV+ (n = 108). Specific written algorithms were used to adjust the ventilator settings in each mode. PAV+ or PS was continued for 48 h unless the patients met pre-defined criteria either for switching to controlled modes (failure criteria) or for breathing without ventilator assistance. Failure rate was significantly lower in PAV+ than that in PS (11.1 vs. 22.0%, P = 0.040, OR 0.443, 95% CI 0.206-0.952). The proportion of patients exhibiting major patient-ventilator dyssynchronies at least during one occasion and after adjusting the initial ventilator settings, was significantly lower in PAV+ than in PS (5.6 vs. 29.0%, P < 0.001, OR 0.1, 95% CI 0.06-0.4). The proportion of patients meeting criteria for unassisted breathing did not differ between modes. PAV+ may be used as a useful mode of support in critically ill patients. Compared to PS, PAV+ increases the probability of remaining on spontaneous breathing, while it considerably reduces the incidence of patient-ventilator asynchronies.
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ABSTRACT: The aim of this study was to evaluate the effects of respiratory rate (RR) at a constant PaCO2 and conventional tidal volume (VT) on the development of ventilator-induced lung injury in normal lungs. Prospective, randomized, experimental study. University research laboratory. Adult male C57BL/6 mice. Four groups of anesthetized mice were exposed to mechanical ventilation with different RRs and VTs. Three groups were assigned to one of three RRs (80, 120, and 160 breaths/min), and VT was set to 12, 10, and 8 mL/kg, respectively (RR80 VT12, RR120 VT10, and RR160 VT8), to achieve normal PaCO2. A fourth group was ventilated at 160 breaths/min and VT of 10 mL/kg (RR160 VT10) with adjustment of dead space. All animals were ventilated for 120 mins with a positive end-expiratory pressure of 1.5 cm H2O and FiO2 of 1. Nonventilated animals were also studied. Arterial blood gases and static pressure-volume curves were not different among groups at the end of the experiment. Independent of ventilator settings, mechanical ventilation was associated with increased bronchoalveolar lavage protein and increased bronchoalveolar lavage and serum interleukin-6. Total bronchoalveolar lavage protein and interleukin-6 were significantly lower in RR80 VT12 and RR160 VT8 compared with RR120 VT10 and RR160 VT10. In all experimental conditions, mechanical ventilation was associated with activation of AKT and ERK1/2 kinases, known to be activated on stretch. Phosphorylation both of AKT and ERK1/2 was lower in RR80 VT12 compared with other groups of ventilated animals. Histologic injury did not differ among nonventilated, RR80 VT12, and RR160 VT8 animals; however, it increased significantly and progressively in RR120 VT10 and RR160 VT10 animals. Mechanical ventilation with conventional VT induces lung injury in normal lungs, even without alteration in lung mechanics. Reduction of RR and VT ameliorates lung inflammation and injury.
Article: Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells[Show abstract] [Hide abstract]
ABSTRACT: The protein kinase encoded by the Tpl2 protooncogene plays an obligatory role in the transduction of Toll-like receptor and death receptor signals in macrophages, B cells, mouse embryo fibroblasts, and epithelial cells in culture and promotes inflammatory responses in animals. To address its role in T cell activation, we crossed the T cell receptor (TCR) transgene 2C, which recognizes class I MHC presented peptides, into the Tpl2(-/-) genetic background. Surprisingly, the TCR2C(tg/tg)/Tpl2(-/-) mice developed T cell lymphomas with a latency of 4-6 months. The tumor cells were consistently TCR2C(+)CD8(+)CD4(-), suggesting that they were derived either from chronically stimulated mature T cells or from immature single positive (ISP) cells. Further studies showed that the population of CD8(+) ISP cells was not expanded in the thymus of TCR2C(tg/tg)/Tpl2(-/-) mice, making the latter hypothesis unlikely. Mature peripheral T cells of Tpl2(-/-) mice were defective in ERK activation and exhibited enhanced proliferation after TCR stimulation. The same cells were defective in the induction of CTLA4, a negative regulator of the T cell response, which is induced by TCR signals via ERK. These findings suggest that Tpl2 functions normally in a feedback loop that switches off the T cell response to TCR stimulation. As a result, Tpl2, a potent oncogene, functions as a tumor suppressor gene in chronically stimulated T cells.
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ABSTRACT: During pressure support ventilation (PS), an abrupt increase in ventilator pressure above the pre-set level is considered to signify expiratory muscle activity. However, relaxation of inspiratory muscles may also cause the same phenomenon, and this hypothesis has not been explored. The aim of this study is to examine the cause of this increase in ventilator pressure, during PS, in critically ill patients. Retrospective study. In a university intensive care unit. Fifteen patients instrumented with esophageal and gastric balloons, and in whom airway pressure (P (aw)) during PS exhibited an acute increase above the pre-set level towards the end of mechanical inspiration were retrospectively analyzed. For each breath, the time of the rapid increase in P (aw) was identified (t (Paw)) and, using the transdiaphragmatic (P (di)) and gastric (P (ga)) pressure waveforms, related to: (1) the end of neural inspiration (peak P (di)) and (2) the time at which P (ga) started to increase rapidly after the end of neural inspiration indicating expiratory muscle recruitment. The t (Paw) was observed 32+/-34ms after the end of neural inspiration, well before (323+/-182ms) expiratory muscle recruitment (identified in eight patients). There was a significant linear relationship between the rate of rise of P (aw) after t (Paw) and the rates of decline of P (di) and inspiratory flow. We conclude that, during PS ventilation, the relaxation of inspiratory muscles accounts for the acute increase in P (aw) above the pre-set level, in addition to the contribution made by the occurrence of expiratory muscle activity.
Top Journals
University of Crete
Retimo, Crete, Greece
- Department of Intensive Care Medicine
Harvard UniversityCambridge, Massachusetts, United States
Tufts Medical Center
Boston, MA, United States
- Molecular Oncology Research Institute
University Hospital of Heraklion
Irákleio, Attica, Greece
- Department of Gastroenterology


text: My girlfriend and I stayed at this beautiful condo. It is close to Whalers Village where they have shops and restaurants right on the beach. The resort has it's own beach and you can rent umbrellas and they even dig a hole and place it in the sand for you. Karin is a great host and was very helpful with any questions we had. There is parking for your car if you rent a car, there is a parking fee per day but very reasonable. The condo has all the amenities of home including washing machine and dryer. We went snorkeling with the snorkeling equipment provided in the condo. We had such a blast we can't wait to go back to Maui and stay at the Whaler again! more


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Originally posted on Cleveland Sports Torture | Last updated 12/9/12
Cleveland Browns vs. Kansas City Chiefs (Week 14) December 9, 2012 Brian Browns 27 Chiefs 6 Sometimes crazy ex-girlfriends win the battle. I'm thinking the Chiefs will wake up with their pet bunny in the crock-pot. Tom Browns 24 Chiefs 14 Browns win an uneventful game, meaning they keep their helmets on and actually win the game. Doug Browns 26 Chiefs 13 Expecting the Browns to win has been an exceedingly rare happenstance these past 14 years or so. Today's tilt against the Chiefs is a game the Browns should win, and rather handily. SamVox Browns 26 Chiefs 20 Thursday night, I dreamed KC routed us and I made out with Mary Kay Cabot in the press box at halftime. Half the dream comes true today. Kevin Browns 28 Chiefs 14 If the Browns don't win today, then the progress made in the la...
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Warner Bros bank again on Man Of Steel star
Picture: Henry Cavill and Gina Carano - 2013 Vanity Fair Oscar Party at Sunset Tower - Arrivals - Los Angeles, CA, United States - Sunday 24th...
Tom Cruise out Henry Cavill in! That's the way it appears to be going in the film adaptation of the hit TV series The Man From U.N.C.L.E, if Variety are to be believed.
We already know that Tom Cruise has dropped out of the action spy film – we don't blame him, with another Mission Impossible film and a new franchise in Jack Reacher on his hands, he probably doesn't need another similar role. However, it would appear that Cavill is going to step into the role, with Variety claiming that he has entered talks with Warner Bros about the film. If he does get involved, he'll be co-starring alongside Armie Hammer and Alicia Vikander in the flick, which will be directed by Guy Ritchie.
Cavill has a good relationship with the studio and had apparently already met for the Hammer role when Cruise had already been negotiations for the lead. He has worked with the studio before, on Superman film Man of Steel, while they've also apparently been looking at him for a co-starring role opposite Chris Hemsworth in In the Heart of the Sea. Given that Cavill currently has a pretty open schedule at the moment, it could be that Warner Bros have found their man. The wider success of the cult 1960's TV adaptation remains to be seen.
Tom Cruise is on the way out...
...is Henry Cavill coming in?


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Loki the shapeshifter by koroaWatch
©2012-2016 koroa
just a random Loki today...
This is absolutely gorgeous. I've been lusting after this on your Etsy shop, and I would plaster this as beautiful propaganda all over my walls and on light poles if I could.
Thank you for telling me, but fortunately it's my etsy shop
I suppose I should've read around a little more lol, my bad I see it's you now. Great work!
I bought this bag on Etsy. The art is gorgeous~
super! podoba mnie sie :>


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Scene and Screen:
Electronic Media and Theatricality
WHAT IS the place or role of "theatricality" in an age increasingly dominated by electronic media? What is the place of "theater"? Or, since there is more than one kind, of "theaters"? What is the relation between such "theaters," which seem to name something concrete, and "theatricality," which need not take place in theaters, at least as commonly understood?
Perhaps most of all, what is the place of "place," the role of "role," which is to say, of the terms to which we have resorted in order to ask these initial questions? What is the relation between the two terms theater and theatricality, which frame our questioning and which we have begun by using as though they were synonymous, which they clearly are not? Whatever else it is, a "theater" is a place, but not only or necessarily one in which plays are performed before audiences. The definition provided by a contemporary dictionary begins with ancient Greek drama and ends with nuclear weapons:
the.aterorthe.atren [ME theatre, fr. MF, fr. L theatrum, fr. Gk
theatron, fr. theasthai to view, fr. thea act of seeing; akin to Gk
thauma miracle] (14c) 1 a: an outdoor structure for dramatic
performances or spectacles in ancient Greece and Rome b: a
building for dramatic performances c: a building or area for
showing motion pictures 2: a place or sphere of enactment of
usu. significant events or action (the ~ of public life) 3 a: a place
rising by steps or gradations (a woody ~ of stateliest view—John
Milton) b: a room often with rising tiers of seats for assemblies
(as for lectures or surgical demonstrations) 4 a: dramatic litera-
ture: PLAYS b: dramatic representation as an art or profession:


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We offer a full schedule of classes and private lessons for all levels of dancer in a variety of styles. Salsa, cha cha, waltz, tango, rumba and foxtrot are jusMore
$1 mil. - $5 mil.in Revenue
10 - 20EmployeesContact people at this company
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ProPub_Iteration_NoTests.312[03] SEIDXWK-7


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Pokémon Odyssey: A New Beginning [T] [Best Veteran 4Q '12]
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May 24th, 2013 (11:12 AM).
Join Date: Jul 2012
Location: Portland, OR
Gender: Male
Nature: Adamant
Posts: 4,863
Vera Fayos
"Loud and clear. There's a bit more to Sovereign than that though. I've been... keeping something from you. Varren... messed with Sovereign's memories. At least he claimed he was going to. He won't remember me."
Vera was unnerved by this thought. Was it really so easy to forget your only friend?
"The problem is, how do we bring out the monster?"
Vera looked once again at the Furret on the ground.
"He's being influenced by something. He's bloodthirsty right now. But he could have killed that Furret at any time. Instead he chose to wait for a fighter. He still remembers who he is, he is still in there. Maybe we can use that, try to make him remember me. The confusion in the midst of battle may be enough to bring it out."
But what about Paladin?
"How confident are you that Paladin can handle Sovereign?"
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Marabu announced that MaraJet DI-LSX, the digital ink for Roland printers, now comes with a new Silver which will exceed all expectations. According to Marabu, the benefits include:
• Fast production speeds for highest efficiency.
• Fully compatible with original parts.
• Ink change-over without prior flushing.
• Hundreds of metallic effects.


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[Note: The point of this post is not about passing judgment on the Duggar family. The question is, does the lifestyle they endorse actually do what they say it will? Is it the perfect formula for a godly family? Or is what we're seeing just a set of normal people striving within a very difficult way of living?This post examines the Duggars' own lives within the paradigm they themselves endorse. Given that we only see what our televisions allow us to-- does what we can see, reflect the image held up to us? And if it does not, how can we be sure about what we can't see?No one expects the Duggars to be perfect. But that is not the question. The real question is: are they really showing us t … [Read more...]
Debt-Free Duggars ~ Pt. 1: How Quiverfull Couples Support All Those Kids!
by HopewellThe Duggar Income Stream [minus TLC] Before TLC and their reality TV show offer came on the scene, Jim-Bob and Michelle Duggar were already on their way to financial security—a situation not normally found in homes with no college-educated adult. But, like the people profiled in the book the Millionaire Next Door, Jim-Bob and Michelle have always lived BELOW their means and have always had common sense about purchases. They also share a vision for the type of family life they wanted to lead. While Jim-Bob did hold a job, and a mortgage, at the time they married he soon realized this was not a sensible way to live. His love of buying cars, fixing them up himself, and reselling th … [Read more...]
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In many cities, such as New York and Philadelphia, the annual Columbus Day parade is cause for celebration. Unfortunately, in Colorado, the birthplace of the Columbus Day holiday, it has been marred for years by protests, tensions and verbal sparring.
We hope — and we know this sounds overly optimistic — that Saturday's parade can proceed without being spoiled by controversy and strife. So far, it's not off to a promising start.
The American Indian Movement of Colorado, which opposes the parade as a "symbol of racism," issued a vitriolic press release last week that was threatening in tone and suggested a confrontation with parade supporters. It branded the Italian-Americans who celebrate their culture and long history in Colorado that day as "racists" — a vile and unnecessary attack.
"If these racists, including those in the local and state governments, think they are going to celebrate the genocide against Native peoples in our homeland for another 100 years, they are mistaken," said Colorado AIM spokesman Glenn Morris. "We will see the racists in the streets on Oct. 6."
Italian-Americans, and anyone who supports the Columbus Day holiday — a federal holiday for more than a generation — have the right to parade, peacefully, through our city streets.
The parade must go forward, but without violence.
American Indians and their supporters have every right to protest the parade, but they should do so without interfering in the activities that so many Coloradans want to enjoy.
The City Council in 2005 passed two ordinances that make it illegal for protesters to physically or vocally disrupt lawful assemblies, while prohibiting obstruction of public passageways, such as streets.
City officials should remind parade opponents, who plan a news conference today to "bring an end to Columbus Day," that Denver has ordinances designed to prevent disruption of the parade and that those laws will be enforced.
Protest the parade, but do so peacefully.