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Publications (23)155.17 Total impact
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ABSTRACT: To investigate how long and how much Mesalazine (M) is available inside the rectal mucosa following its topical instillation, in patients (pts) with Ulcerative Colitis (UC). Two rectal biopsies for M concentration were obtained from 45 UC pts in clinical remission and on oral M treatment (OT), before a 4 g enema randomly given to consentient pts every day (Group A, 15 pts), every 2 days (Group B, 15 pts) and every 3 days (Group C, 15 pts). Two additional biopsies were taken 1, 2 and 3 days after the last enema in group A, B and C respectively, at least 10 days later. All biopsies were immediately frozen at − 80 °C for later assay by means of high-performance light chromatography (HPLC). Data were analyzed using Student's t-test. Mean values ± standard deviation of M mucosal concentration (ng/mg of tissue) were 1.32 ± 1.41, 56.1 ± 39.2, 9.65 ± 6.60, and 6.39 ± 5.03 in pts receiving OT alone, groups A, B and C, respectively. Values in Group A were statistically higher (p < 0.001) than those in Groups B and C while no differences were found between Groups B and C. Values of OT were lower than groups A, B and C. M mucosal concentration rapidly decreases 2 days after a 4 g enema, but after three days is still higher than OT alone. These results may provide data which would be useful to plan topical therapy and improve adherence to treatment.
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ABSTRACT: Abstract An inverted colonic diverticulum is reported rarely; a review of published articles revealed 15 reported cases. It may resemble adenomatous polyps or carcinoma and it frequently coexsists with diverticular disease. The patient had developed an inverted colonic diverticulum, with a long thick stalk; it was not associated with colonic diverticula and had been responsible for her ematochezia and lower abdominal pain. Resection resulted in production of an acute abdomen. No histological evidence of adenoma was found. At six months follow-up the patient remains asymptomatic.
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ABSTRACT: Diverticular disease of the colon is a complex syndrome that includes several clinical conditions, each needing different therapeutic strategies. In patients with asymptomatic diverticulosis, only a fiber-rich diet can be recommended in an attempt to reduce intraluminal pressure and slow down the worsening of the disease. Fiber supplementation is also indicated in symptomatic diverticulosis in order to get symptom relief and prevent acute diverticulitis. In this regard, the best results have been obtained by combination of soluble fiber, like glucomannan, and poorly absorbed antibiotics, like rifaximin, given 7-10 days every month. For uncomplicated diverticulitis the standard therapy is liquid diet and oral antimicrobials, usually ciprofloxacin and metronidazole. Hospitalization, bowel rest, and intravenous antibacterial agents are mandatory for complicated diverticulitis. Haemorrhage is usually a self-limited event but may require endoscopic or surgical treatment. Once in remission, continuous fiber intake and intermittent course of rifaximin may improve symptoms and reduce diverticulitis recurrence. These preventive strategies will likely improve patients' quality of life and reduce management costs. A surgical approach in diverticular disease is needed in 15-30% of cases and consists of removing the intestinal segment affected by diverticula. It is indicated in diffuse peritonitis, abscesses, fistulas, stenosis and after the second to fourth attack of uncomplicated diverticulitis. Young people and immunocompromised patients are more likely to be operated.
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ABSTRACT: In cross-sectional studies, it was demonstrated that the therapeutic effect of mesalazine is closely related to its mucosal concentration. This study was carried out to verify in a longitudinal study if it was possible to improve the clinical course of ulcerative colitis at high risk of recurrence by increasing mucosal mesalazine concentration. Eighteen consecutive ulcerative colitis patients on continuous oral 5-ASA treatment (2.4-3.2 g/day) in clinical remission who had had at least four moderate to severe relapses in the preceding 2 years (referred period) were assigned to assume oral (3.2-4.8 g/day) and topical (4 g/day) mesalazine in order to increase mucosal drug concentration and were followed up for 2 years (study period). The localisation of disease was 12 pancolitis, six left colitis. The number and severity of recurrences, number of visits and endoscopies, courses of steroids and days of hospitalisation were compared with those of the previous 2 years. Rank signed test for paired data was used for statistical analysis. The total number of recurrences was significantly lower during the study period in comparison with that of referred period (8 versus 80, respectively, p < 0.0001). No courses of steroids or hospitalisation were necessary during study period in comparison with those of referred period (0 versus 33, p < 0.0001; 0 versus 93, p = 0.03, respectively). A total number of 249 visits were done during the referred period and 116 during the study period (p < 0.0001) with a total of 87 endoscopies during referred period and 44 during study period (p < 0.0001). The continuous use of topical mesalazine associated with a high oral dosage significantly improves the clinical course of ulcerative colitis patients at high risk of relapse.
Article: Infliximab in refractory pouchitis complicated by fistulae following ileo‐anal pouch for ulcerative colitis[Show abstract] [Hide abstract]
ABSTRACT: To determine the efficacy of infliximab in the treatment of chronic refractory pouchitis complicated by fistulae following ileal pouch-anal anastomosis for ulcerative colitis. This open study included seven patients (four females, three males) with chronic refractory pouchitis complicated by fistulae. Pouchitis was diagnosed by clinical, endoscopic and histological criteria. The sites of the fistulae were as follows: pouch-bladder in one, vaginal in three, perianal in two, and both vaginal and perianal in one. Extra-intestinal manifestations (erythema nodosum, arthralgia) were present in four patients. Crohn's disease was carefully excluded in all patients after re-evaluation of the history, re-examination of the original proctocolectomy specimen and examination of the proximal small bowel. All patients had been treated with antibiotics and three with steroids. Patients received infliximab, 5 mg/kg, at 0, 2 and 6 weeks. Azathioprine (2.5 mg/kg) was also started for all patients as bridge therapy. Clinical response was classified as complete, partial or no response. Fistulae closure was classified as complete (cessation of fistulae drainage and total closure of all fistulae), partial (a reduction in the number, size, drainage or discomfort associated with fistulae) or no closure. The pouchitis disease activity index and quality of life were also used as outcome measures. Clinically, all patients improved. At the 10-week follow-up, six of the seven patients had a complete clinical response, and five had complete fistulae closure. At the 10-week follow-up, the median pouchitis disease activity index decreased from 12 (baseline) (range, 10-15) to 5 (range, 3-8); the median quality of life decreased from 37 points (range, 33-40) to 14 (range, 9-18). Erythema nodosum and arthralgia showed complete remission soon after the first infusion of infliximab. These preliminary results indicate that infliximab may be recommended for the treatment of refractory pouchitis complicated by fistulae following ileal pouch-anal anastomosis for ulcerative colitis.
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ABSTRACT: We examined the efficacy of cyclic long-term administration of rifaximin, a broad spectrum, poorly absorbable antibiotic, in obtaining symptom relief in a large series of patients with uncomplicated diverticular disease, and compared the incidence of episodes of diverticulitis in the group treated with rifaximin to that in a group receiving fiber supplementation only. In a multicenter, prospective, open trial, 968 outpatients with uncomplicated symptomatic diverticular disease were randomized to either fiber supplementation with 4 g/day glucomannan plus 400 mg rifaximin twice daily for 7 days every month ( n=558) or 4 g/day glucomannan alone ( n=346). Clinical evaluation was performed on admission and at 4-month intervals for 12 months. After 12 months the group treated with glucomannan + rifaximin showed fewer symptoms (abdominal pain/discomfort, bloating, tenesmus, diarrhea, abdominal tenderness) and a lower global symptomatic score. Overall 56.5% of the patients treated with glucomannan + rifaximin and 29.2% of those treated with glucomannan alone were asymptomatic at 12 months ( P<0.001). The rate of complications (diverticulitis and rectal bleeding) was 1.34% in the rifaximin + glucomannan group and 3.22% in the glucomannan alone group ( P<0.05). Cyclic administration of rifaximin is effective in obtaining symptom relief in uncomplicated diverticular disease of the colon. The incidence of episodes of diverticulitis in the group treated with rifaximin was lower than that in the group treated with glucomannan alone.
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ABSTRACT: Data about colonic mucosa transport of short-chain fatty acids in cirrhotic patients are still lacking. The aim of the present study was to compare the rectal mucosa transport of n-butyrate and its effect on transport of other electrolytes and endoluminal pH in normal subjects and in cirrhotic patients by using a rectal dialysis technique. Thirteen subjects with normal hepatic function tests and 17 cirrhotic patients were enrolled. Dialysis bags containing 80 mmol/liter of butyrate in a neutral pH (6.8) electrolyte solution were placed in the rectum of enrolled subjects for 60 min. Net transport rate was calculated for butyrate, sodium, chloride, potassium, and bicarbonate. The differences in pH between initial and final dialysis solutions was also evaluated in the two groups in the study. Net butyrate absorption was significantly lower in cirrhotic patients than in controls (65.2 +/- 38.6 vs 101.2 +/- 45.3 nmol/min/cm2, respectively; P = 0.02). Furthermore, cirrhotic patients showed a lower HCO3 secretion than controls (-26.9 +/- 19.9 vs -45.1 +/- 20.0, respectively; P = 0.01). No differences were found in transport of the other electrolytes. The pH in the final dialysis solution in cirrhotic patients was not significantly lower than in the controls (7.15 vs 7.35; P = 0.1). In conclusion, the impairment of butyrate absorption and the concurrent reduction of bicarbonate secretion observed in cirrhotic patients may suggest a selective hypoactivity of apical HCO3-/SCFA- antiport located at the colonocyte apical membrane.
Article: Apo3tosis and proliferation of colonic epithelial cells in dextran sulphate sodium-induced colitis in rats
Article: Mucosal 5-aminosalicylic acid concentration inversely correlates with severity of colonic inflammation in patients with ulcerative colitis.[Show abstract] [Hide abstract]
ABSTRACT: The treatment of ulcerative colitis (UC) with 5-aminosalicylic acid (5-ASA) does not have the same therapeutic effect in all patients. We tested the hypothesis that the effectiveness of the drug is related to its mucosal concentration. Twenty one UC patients receiving oral 5-ASA (2.4-3.2 g/day) were enrolled in the study. Four were also receiving topical treatment (2 g/day). Six endoscopic biopsies were taken from the rectum for measurement of 5-ASA concentrations (ng/mg) by HPLC; soluble interleukin 2 receptor (sIL-2R) concentrations (U/ml) were measured by ELISA and histology. Endoscopic and histological appearance was graded on a four point scale (0-3). The Wilcoxon's rank test and Pearson's correlation coefficient were used for statistical analysis. Mucosal concentrations of 5-ASA were significantly higher (p=0.03) in patients with endoscopic scores of 0-1 compared with those with scores of 2-3 (16.1 (range 10.2-45) v 5. 5 (3.5-17.4), respectively) and in patients with lower histological inflammation compared with those with more severe scores (17.4 (10. 5-45) v 8.9 (3.5-17.2), respectively) (p<0.01). In contrast, mucosal sIL2-R concentrations were significantly lower in patients with slight endoscopic and histological lesions than in those with more severe disease. A significative inverse correlation (r=-0.85) was found between 5-ASA and sIL-2R mucosal concentrations (p=0.00008). In patients with UC, in the same area of the intestinal tract, we found that the higher the 5-ASA mucosal concentrations, the lower the IL-2R levels and endoscopic and histological scores. We hypothesise that maintenance of high mucosal 5-ASA concentrations in all colonic segments could contribute to improve clinical outcome in UC patients.
Article: Polyunsaturated fatty acid dietary supplementation: An adjuvant approach to treatment of Helicobacter pylori infection[Show abstract] [Hide abstract]
ABSTRACT: Recent studies suggest that PUFAs may have a role in both duodenal ulcer incidence and H. pylori growth in vitro. This study investigated the effect of dietary PUFA supplementation on H. pylori in vivo.Fifteen H. pylori positive patients with mild functional dyspepsia were enrolled. H. pylori was histologically detected using both rapid urease test and histology by a blinded observer. Two grams of a dietary mixture of fish oil and blackcurrant seed oil (v/v) were fed daily for eight weeks and magnitude H. pylori infection determined both at the end of treatment and six months later.H. pylori clearance was obtained in eight out fifteen patients (53%). No migration of bacterium from antrum to fundus was observed. H. pylori eradication was obtained in 20% of these patients.The oil mixture used in this study produced good bacterial clearance, but poor H. pylori eradication. The effect of PUFA on H. pylori clearance may be due to modification of cellular membranes of both bacterium and host. These changes may reduce H. pylori virulence by interfering with bacterial adhesion to gastric epithelial cells or through a direct bactericidal effect on the micro-organism. If these data are confirmed, PUFA may be considered has adjuvant treatment for drugs usually employed for H. pylori eradication.
Article: Anastomotic configuration and mucosal 5-aminosalicylic acid (5-ASA) concentrations in patients with Crohn's disease: A GISC study[Show abstract] [Hide abstract]
ABSTRACT: OBJECTIVE:Recurrence of Crohn's disease quite inevitably occurs after resection of distal small bowel and proximal colon, involving the neoterminal ileum close to the anastomosis. Oral 5-aminosalicylic acid (5-ASA) administered soon after surgery delays recurrence and reduces its severity. We recently observed that in operated patients submitted to prophylactic treatment with oral 5-ASA the rate of recurrence was significantly higher in those with end-to-end anastomosis than in those with other types of anastomosis (end-to-side, side-to-side). The hypothesis investigated in the present study was that patients with end-to-side or side-to-side anastomosis would benefit from a higher mucosal concentration of 5-ASA with respect to patients with end-to-end anastomosis. Therefore, the mucosal 5-ASA concentration was measured in the perianastomotic area of both groups.METHODS:The study was carried out in 19 patients submitted to radical surgery for Crohn's ileitis or ileocolitis, under oral prophylactic treatment with 5-ASA (Asacol). All patients were on regular endoscopic follow-up and were free of recurrence. Two biopsies were collected 3 cm from the anastomosis, in the neoterminal ileum, and two biopsies were collected at the colonic site 3 cm below the anastomosis. 5-ASA concentrations (ng/mg) were measured in tissue homogenates by high-performance liquid chromatography (HPLC) with electrochemical detection.RESULTS:The mucosal concentration of 5-ASA in the neoterminal ileum was significantly lower in patients with end-to-end anastomosis than in those with other types of anastomosis (median values: 29.4 ng/mg vs 92.9 ng/mg respectively; p 90 ng/mg, compared with the 57% of patients in the group with other types of anastomosis. No differences were observed for colonic biopsies.CONCLUSIONS:The different mucosal concentrations in these two groups may be explained by the difference in segmental transit time induced by the different anastomotic configurations. A slower preanastomotic transit time, demonstrated in patients with end-to-side or side-to-side anastomosis, could offer a prolonged contact time between the intestinal content and the mucosa, resulting in an increase in drug absorption.
Article: Anastomotic configuration and mucosal 5-aminosalicyclic acid (5-ASA) concentrations in patients with Crohn's disease: a GISC study. Gruppo Italiano per lo Studio del Colon e del Retto.[Show abstract] [Hide abstract]
ABSTRACT: Recurrence of Crohn's disease quite inevitably occurs after resection of distal small bowel and proximal colon, involving the neoterminal ileum close to the anastomosis. Oral 5-aminosalicylic acid (5-ASA) administered soon after surgery delays recurrence and reduces its severity. We recently observed that in operated patients submitted to prophylactic treatment with oral 5-ASA the rate of recurrence was significantly higher in those with end-to-end anastomosis than in those with other types of anastomosis (end-to-side, side-to-side). The hypothesis investigated in the present study was that patients with end-to-side or side-to-side anastomosis would benefit from a higher mucosal concentration of 5-ASA with respect to patients with end-to-end anastomosis. Therefore, the mucosal 5-ASA concentration was measured in the perianastomotic area of both groups. The study was carried out in 19 patients submitted to radical surgery for Crohn's ileitis or ileocolitis, under oral prophylactic treatment with 5-ASA (Asacol). All patients were on regular endoscopic follow-up and were free of recurrence. Two biopsies were collected 3 cm from the anastomosis, in the neoterminal ileum, and two biopsies were collected at the colonic site 3 cm below the anastomosis. 5-ASA concentrations (ng/mg) were measured in tissue homogenates by high-performance liquid chromatography (HPLC) with electrochemical detection. The mucosal concentration of 5-ASA in the neoterminal ileum was significantly lower in patients with end-to-end anastomosis than in those with other types of anastomosis (median values: 29.4 ng/mg vs 92.9 ng/mg respectively; p < 0.001). Six of 10 patients (60%) with end-to-end anastomosis, but none of the nine patients with other types of anastomosis, showed 5-ASA mucosal concentrations <40 ng/mg at the neoterminal ileum. On the contrary, no patients with end-to-end anastomosis showed mucosal concentrations of 5-ASA >90 ng/mg, compared with the 57% of patients in the group with other types of anastomosis. No differences were observed for colonic biopsies. The different mucosal concentrations in these two groups may be explained by the difference in segmental transit time induced by the different anastomotic configurations. A slower preanastomotic transit time, demonstrated in patients with end-to-side or side-to-side anastomosis, could offer a prolonged contact time between the intestinal content and the mucosa, resulting in an increase in drug absorption.
Article: Rectal and colonic mesalazine concentration in ulcerative colitis: Oral vs. oral plus topical treatment[Show abstract] [Hide abstract]
ABSTRACT: To measure mucosal concentrations of mesalazine in ulcerative colitis patients treated with oral mesalazine alone, compared to patients treated with both topical and oral mesalazine. Twenty-two patients with mild to moderate ulcerative colitis were randomized to receive 2.4 g/day of oral mesalazine (11 patients) or 2.4 g/day oral plus 4 g/day of topical mesalazine (11 patients). After 2 weeks of treatment, endoscopic biopsies specimens were taken from the rectum and in descending colon just distal of the splenic flexure and stored to -80 degrees C for later assay (HPLC). Wilcoxon's rank sum test for unpaired data was used for the statistical analysis. Mucosal levels of mesalazine in the rectum were significantly higher in patients who received oral plus topical treatment than in those who had oral treatment alone (52.1 ng/mg, range: 13.6-122.1 vs. 0.2 ng/mg, range: 0.2-9.7, respectively; P < 0.0001). Similarly, in the descending colon, the mucosal concentrations of mesalazine were significantly higher in patients who had oral plus topical treatment than in those receiving oral treatment alone (46.6 ng/mg, range: 6-112.6 vs. 15.9 ng/mg, range: 2.3-42.4, respectively; P=0.01). Topical treatment of mesalazine significantly increases mucosal concentrations of mesalazine up to the splenic flexure, supporting the rationale to treat left-sided ulcerative colitis with topical formulations of mesalazine.
Article: Prevention of post-operative recurrence of Crohn's disease requires adequate mucosal concentration of mesalazine. Gruppo Italiano per lo Studio del Colon e del Retto.[Show abstract] [Hide abstract]
ABSTRACT: Surgical resection of Crohn's disease is followed by early recurrence in a high percentage of patients. Mesalazine has been shown to be effective in the prevention of post-operative recurrence, but some 50% of patients under treatment recur at 3 years of follow-up. To establish whether the mucosal concentration of mesalazine might affect the development of post-operative recurrence. Colon-ileoscopy was performed in 25 consecutive patients resected for Crohn's disease. The mean time from surgery was 14 months. After the operation, all patients were taking oral mesalazine (Asacol, 2.4 g/day). Ten patients showed signs of endoscopic recurrence (apthae, ulcers, narrowing of the lumen) in the neoterminal ileum, five of whom also showed juxta-anastomotic colonic involvement. Fifteen patients were free of recurrence. At endoscopy, four biopsies were taken from the perianastomotic area (two specimens at the ileal site and two specimens at the colonic site of the anastomosis). The specimens were weighed and immediately frozen at -80 degrees C. Mesalazine concentration (ng/mg) was measured in tissue homogenates by high- performance liquid chromatography with electrochemical detection. Fisher's exact test was used for the statistical analysis. The mean value of mucosal mesalazine concentration, expressed as ng/mg of tissue, was significantly lower in patients with recurrence than in those without recurrence both in the ileum (mean +/- s.d.: 21.6+/-28.3 vs. 70.9+/-47.4; P = 0.007) and in the colon (25.8+/-26.4 vs. 60.3+/-32.5; P = 0.010). The mucosal concentration of mesalazine in the juxta-anastomatic area is significantly lower in patients with recurrence than in those free of recurrence. These data could suggest an association between mucosal mesalazine concentrations and the clinical effectiveness of the drug.
Article: Circulating soluble factor-inhibiting natural killer (NK) activity of fresh peripheral blood mononuclear cells (PBMC) from inflammatory bowel disease (IBD) patients[Show abstract] [Hide abstract]
ABSTRACT: This study was performed in order to assess the cytotoxic activity, both natural (NK) and antibody-dependent (ADCC), of PBMC from 38 IBD patients and correlate it with their clinical features. Cytotoxicity assays were performed using sensitive target cells for NK and ADCC activities. In some experiments, highly purified NK cells, obtained both by Percoll density gradient and by co-culturing non-adherent PBMC with RPMI 8866 feeder cells, were used as effector cells. Furthermore, we evaluated NK cell parameters such as number, surface expression of adhesion molecules (CD11a/CD18, CD49d and CD54) and response to different stimuli. We observed a decreased NK cytotoxicity of PBMC from IBD patients, both in ulcerative colitis (UC) and Crohn's disease (CD), independently of the clinical activity of disease. In contrast, the ADCC lytic activity was within normal range. The lower NK cytotoxic activity observed in our IBD patients cannot be related to a decreased number of NK cells, surface expression of adhesion molecules, defective response to IL-2 and maturative defect. Decreased NK activity was induced in PBMC of controls when serum of patients was added and this was unrelated to monocyte-derived modulating factor(s). Our data show a decreased natural killing by fresh PBMC from IBD patients. This lower activity seems to be unrelated to a primary NK cell defect, since purified NK cells exhibited normal levels of killing. It might be hypothesized that serum factors, possibly derived from lymphocytes, with inhibitory properties on NK activity, might be functionally active in the blood of IBD patients, thus modulating NK activity.
Article: Synergic interaction between cholinergic muscarinic and NK1 and NK2 tachykinin (TK) transmission on rabbit Distal colon propulsion (RDC Prop.)
Article: Pimpo MT, Frieri G, Saltarelli P, et al. Effects of cisapride on abnormally prolonged endogastric alkalinity time and delayed gastric emptying in cirrhotic patients. Hepatogastroenterology 43: 1678-84[Show abstract] [Hide abstract]
ABSTRACT: An abnormally prolonged alkalinity time in endogastric long-term pH monitoring has been previously demonstrated in cirrhotic patients. Recently a growing body of evidence suggest the existence of severe abnormalities of gastric emptying in the same patients and more generally of gastrointestinal motility changes in many portal hypertensive animal models. Assuming that there was a good correlation between endogastric alkalinity and a delayed emptying of gastric bile reflux, the aim of this study was to evaluated the effect of a gastrokinetic drug, Cisapride, both on circadian gastric pH and on gastric emptying in cirrhotic patients compared with controls. Ten in patients with chronic liver disease and portal hypertension (six males, four females, median age 49.5, range 28-59) were enrolled. The control group included twelve inpatients without cirrhosis (seven females and five males, average age 45 years, range 31-54) free from endoscopic esophagogastro-duodenal lesions. The subjects were submitted to a 24h endogastric pH monitoring and gastric emptying study before and after administration of Cisapride (10 mg tid for three days). To gastric emptying study we used an ultrasonographic method evaluating the ratio between the antropyloric region volume before and at a fixed time after a solid/liquid standard meal. Basal 24 h gastric pH monitoring in cirrhotic patients showed a significant prolonged time of alkalinity (pH conventionally over 4) during the entire registration and mainly in postprandial period vs controls. The same patients group showed also a delayed gastric emptying when compared to controls. Cisapride administration significantly reduced both the abnormally prolonged alkalinity time and delayed gastric emptying in cirrhotic group without affecting the same parameters in the control group. Cisapride significantly reduces both the delayed gastric emptying time and the abnormally prolonged alkalinity time in cirrhotic group. Taken together, the results offered an indirect evidence that abnormally prolonged alkalinity in cirrhotic patients may be due, at least in part, to changes in gastroduodenal motility leading to a reduced gastric clearance of potentially noxious duodeno-gastric alkaline reflux.
Top Journals
Ospedale San Pietro FatebenefratelliRoma, Latium, Italy
Università degli Studi dell'Aquila
Aquila, Abruzzo, Italy
- • Department of Internal Medicine and Public Health
- • SS in Internal Medicine
Sapienza University of Rome
Roma, Latium, Italy
- Department of Surgical Sciences
The American University of RomeRoma, Latium, Italy


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According to the Agency for Healthcare Research and Quality, (a division of U.S. Health and Human Services Department), the number of Americans who will suffer functional disability due to a chronic disease is expected to increase at least 300 percent by 2049. Currently, almost 75 percent of the elderly (age 65 and over) have at least one chronic illness and 50 percent have at least two chronic illnesses. Aging is an important marker of the accumulation of risks for chronic disease. A prevention- focused paradigm is necessary to break this trend.
The North Carolina State Grange has been an advocate for rural North Carolina since 1929. We believe that all citizens should have access to quality healthcare that is affordable. We further believe that lower income individuals should receive financial assistance with acquiring needed medications. The 340B program enacted by Congress was intended to provide the necessary support for the vulnerable and uninsured to have access to medications.
One of the great achievements of the last 100 years has been the significant increase in the lifespan of Americans. By 2050 it is estimated that 20 percent of the total U.S. population will be over the age of 65. While this is something to celebrate, there is also a downside. With the expected growth of the aging population, we expect to see a significant rise in many chronic diseases where age is a major risk factor.
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As Americans live longer, how can we tackle aging as a major risk factor for chronic disease?
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To tackle aging as a major risk factor for chronic disease, we need to develop a more aggressive public-private investment strategy in prevention and health promotion.
On the private side, as the Medicines in Development for Older Americans report shows, biopharmaceutical research companies are developing over 400 medications for the top chronic diseases to allow these older adults to live a better and in some cases longer life.
06.17.14 | By
A recent Roundtable in Washington D.C. underscored why, with the growing focus on value-based payment in health care, it's more important than ever to focus on the patient. We can't advance patient-centered care if we aren't measuring and incentivizing what matters to patients. We have begun to see this shift in the premarket arena via patient-focused drug development and in comparative effectiveness research at the Patient-Centered Outcomes Research Institute.
Like both sides of a coin, there are two sides in the battle against cancer. We are making huge strides in preventing, slowing and in some cases beating many forms of cancer, but there are still considerable roadblocks to reaching our ultimate goal of a world free from cancer.
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MLP FiM: G4 Filly Luna Custom by ClaytacularWatch
©2013-2016 Claytacular
Yes, she has been relisted. I will be going away eventually, and I do want to find Luna a home. I don't think I can keep all my customs.. She was made from a Sweetie Belle base, and then had her mane, tail, wings, shoes, and tiara added (made with Sculpey oven-bake clay). She is actually a darker navy blue than what the picture shows. If anyone is interested, her ebay link is here: [link]
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Tag Search
Games Tagged with "retro"
Apr 2008
If "retro" to you means huge chunky pixels, bleeping and blerping sounds and gameplay that doesn't lead you by the hand, then Attack of the Meeplings may be just the game for you. This Java-based shooter is glorious, retro-styled fun from top to bottom, especially its soundtrack.
Mar 2008
Jasper's Journeys is a downloadable platform game that plays much like an old-school side-scroller where exploration is essential, power-ups are few, speed is often encouraged, and secret areas are plentiful. In many ways it's similar to Brad Borne's The Fancy Pants Adventure games (or even Sonic the Hedgehog, Super Mario Bros, or Jazz Jackrabbit), though with a decidedly different atmosphere and feel.
Feb 2008
Created to promote Microsoft's TechNet service, Server Quest is an adventure game lovingly crafted in the style of early 90s Lucasarts/Sierra titles. From its blocky visuals, kooky musical score and off-beat sense of humor, it's like stepping fifteen years in the past without having to fire up the ole time machine. It's also one of the geekiest games you'll ever play with a number of minigames quizzing you on your knowledge of IT lingo.
Dec 2007
Thule Trail is a re-imagining of the grade school classic, Oregon Trail, but instead of playing a family of 19th century immigrants, you play a group of 20 somethings road-tripping to a music festival. Instead of going to Oregon, you're going to Santa Barbara. The game takes its name from the 20th century occult society that sought the road to Atlantis; the music festival you travel to is called Atlantis, so it works. The rest of the game follows suit like a friendly slacker.
Dec 2007
Hearken back to those adrenaline-happy days with Vector Runner, an arcade action game concerned purely with the sensation of speed. Control a humble blue cube on its journey down a futuristic highway, dodging deadly pyramids of various shapes and sizes. Wherever you need to be, you're going there fast.
Oct 2007
The next entry is a game from a team of developers, three representing Stimunation Games and a couple others from the Flashkit Games forums. JayIsAdventure is an old-school style graphic adventure game with a creative interpretation of the "ball physics" theme. I will say no more than that, the rest is up to you to discover and comment freely about.
Sep 2007
Pile O'Bubbles is a new action/puzzle game from the creator of Gravity Pods, Keith Peters of Wicked Pissah Games. It combines fast reflex mouse clicking with a bit of thinking to create a game that's brain wrenching with a touch of (very) old-school arcade style as well.
Aug 2007
The Sea of Glomp is an adventure-themed Flash game created by Paul Kramm that draws heavy inspiration from old-style adventure games such as ... Adventure! You play a young fish whose egg has been stolen by a creature that looks like a bat. An underwater bat. You set out on a quest to find the egg, a task that takes you through some of the strangest parts of the sea you could imagine.
Aug 2007
The main focus of Knytt Stories is atmosphere, environment and exploration, not complex gameplay and a barrage of media. With Knytt Stories you'll spend most of your time wandering around sparsely populated worlds looking for a few rare items, enjoying the beautiful visuals and ambient music the whole time. It's a unique experience in gaming and will pull you in from the moment you start playing.
Jul 2007
Gravity Pods is a physics-based vector shooting/puzzle title created by Wicked Pissah Games. The goal is to fire a projectile and hit a target across the screen. Barriers are usually in the way, but by using gravity pods you can bend the path your projectile takes to send it virtually anywhere on the screen.
Jul 2007
After months of waiting, it's finally here! Nitrome has just rolled out Hot Air 2, the highly anticipated sequel to the balloon physics game Hot Air. The new incarnation is bigger, better, more intricate and more stylish than the original, proving it's possible to take an already polished game idea and turn it into something even better. Plus, you get to make your own balloons!
Jun 2007
In Rat Maze 2, you are a mouse in a maze and you must collect all the pieces of cheese in the shortest time possible. Use the arrow keys for movement to zip around the maze. Running over a cheese is as good as eating it, so no time is wasted collecting them all. Simple retro fun from the highly talented developers at PixelJam.
Apr 2007
Sunday Lawn, a game from the creator of Castle Smasher, Donut Games, puts you in control of Charlie whose job is to cut the grass around his house. Unfortunately there are dogs, hedgehogs, and various other obstacles standing in the way of monocotyledonous perfection.
Apr 2007
Benjamin Colwell of Indie Flash Arcade has just released this remarkably attractive arcade Flash game that blends the casual gameplay of classic video games with a stylish (and stunning!) presentation. The result is POD: Planetary Orbital Defense, a 15-level shoot-em-up bonanza that culminates in a boss fight against an alien invasion.
Apr 2007
Dot Action 2 is a cute little platformer with a personality. For those seeking some old-school gameplay, OffGao of Japan may have just what you're looking for. At first glance these games may appear as nothing special, but as was the case with many early video games, it's all about the gameplay.
Dec 2006
In Flatland, it is your mission to destroy wave after wave of... things. You get points. OK, the idea isn't completely original, but the design is quite interesting. At first you start off in a tiny ship with litle armor and a miniscule weapon. Destroying enemies will cause them to explode in an array of large blocky pixels, the collection of which upgrades your ship. The interesting bit is that collecting an odd number of them gives you an odd shaped ship until you gather more and regain composure.
Dec 2006
Snake Classic takes this simple game mechanic and gives it new life with catchy music, tons of gameplay options (how many dots to grab, sound effects, etc.) In addition you get to choose what colors your snakey protagonist will have using a grid of dots that looks like something out of a kid's dream box of marbles.
Dec 2006
Knytt is a downloadable game of exploration and atmosphere for Windows created by the author of Within a Deep Forest, Nifflas. The game emphasizes discovery and intrigue over everything and creates a massive world with varied environments and lots of places to explore. A spacecraft kidnapped the cat-like Knytt from his home but crashes on its way back, sending pieces of the ship across a mysterious planet. Your job is to traverse the barren world in search of the missing parts and try to get back home.
Nov 2006
Those of you who enjoy a stripped-down text adventure game and don't mind a bit of repetition will get a bit of fun out of these DHTML-based Enchanted Forest games. The point is to get as much gold as you can. For such a simple game it's surprisingly addictive, but don't worry—if you're a true casual gamer, you can leave your game at any time and when you return, it will be waiting exactly as you left it.
Oct 2006
Bill the Demon is an action adventure platformer with a very nice old-school flair to it. In the game you play as Bill, a lowly demon with a voracious appetite for human souls. To prove himself worthy to his peers, Bill sets out on a mission to the Ninth Circle of Hell to fetch the devil's autograph.
Oct 2006
Pod Panic is a gorgeous little arcade Flash shooter that is simple to play and terribly addictive. Each level presents you with an increasing number of pods, round bumper-like objects that tend to gravitate towards your ship, and a string-creature that is rather hypnotizing to watch. Great old-school arcade fun in a tight little package.
Oct 2006
Empires and Dungeons has been receiving a lot of praise for its stripped-down mechanics and surprisingly captivating gameplay. Taking on the role of a medieval emperor, you must gather resources to help build an army, both to attack your rivals and to defend your castle. Along the way you'll venture into deep dungeons, meet mysterious traders, pillage in the name of the empire and much, much more.
Aug 2006
Skatefall is John Freeborn's tribute to one of the earliest platformers, the Atari 2600's Pitfall! With a bodacious new skateboard, online scoreboard, bonus items and powerups, 2D platforming has a new name: Skatefall Harry. As a homage, Skatefall is extremely effective and faithful; the graphics and sound are perfect and the difficulty, while formidable, is appropriate.
Aug 2006
An adventure game in the classic sense of the genre, as well as in a more low-tech DHTML implementation, the Mystery of Castle Wildenburg combines original photography of Germany's deep woods with the cartoon drawings of artist Aurèle Mechler, which together produces a unique visual appeal to this engaging and compelling Web-based game by Jörg Jochims.
Jun 2006
Gamma Bros. is a deliciously slow-paced old-school space shooter created by PixelJam. It's written in flash and offers both an online version and downloadable files for the Mac and Windows. Although simple in looks and design, Gamma Bros. gives the illusion of a massive game world interspersed with moments of action and quiet space floating.
Jun 2006
Rainbow Wars is a retro-style arcade shooter available as a free download for Windows, and it is one of those rare finds that becomes an instant favorite once you see it in action. Sporting similar controls to that of the classic Robotron, in which two joysticks are used to control movement and firing separately, this game captures the essence of a classic arcade experience in a well-developed albeit small package.
May 2006
Why are so many of the most difficult video games also the cutest? Maybe my brain just automatically forgets games that are both ugly and frustrating. Added to the "cute but evil" list comes Within a Deep Forest, a completely free downloadable game for Windows that casts you as a little blue ball, bouncing around a delightfully whimsical little world filled with the most frustrating jumping puzzles known to man.
Apr 2006
Thy Dungeonman 3: Behold Thy Graphics! is a parody of the old 5¼-inch floppy text and graphic adventure games. Made by Videlectrix, Homestar Runner's fictional software design company, Dungeonman 3 sports "state-of-the-art amber monochrome visuals" (circa 1980), real-time simulated medieval English text, a parser that talks back to you, and enough mocked adventure game cliches to fill your beer stein twice full.
Mar 2006
GridWars is a free downloadable (for PC or Mac) old-school-style shooting game that's remarkably similar to Geometry Wars on the Xbox. Your small ship sits in a one-screen grid and vectorized enemies spawn to attack. Use your any-directional gun to stay alive while you rake in points.
Jan 2006
From Mark Arenz and his Ridiculopathy site full of ridiculousness comes this hilarious new adventure with an old-school dungeon flair. The game is light-hearted and pokes fun at some classic games as well as itself. Good fun and a nice change from the usual point-and-click approach to Flash adventure games.
Jan 2006
Yard Invaders is a Shockwave action arcade game similar to Space Invaders, and yet with some unique gameplay twists. The game features RobotDuck's characteristic child-like hand-drawn graphics and animation, and yet it is packed with gameplay that is surprisingly refined for the game's appearance.
Dec 2005
Hot Air is a delightful action game with irresistible pixel graphics reminiscent of an old-school Mario game. Navigate a hot air balloon from its green starting platform to the red landing platform within each level. To succeed you will need to maneuver around obstacles and onto platforms, collecting keys to open gates while avoiding just about everything that will make the balloon pop. Much easier said than done.
Aug 2005
Another one for the classic games section, I made a reference to this game when reviewing Swarm due to the way the enemies swarmed onto the play field. Galaca is a Java applet 'clone' of the classic action arcade game Galaga. Originally created by Namco and released as a coin-op amusement...
Jul 2005
Let Swarm take you back to the golden days of classic arcade shooters with this fast-paced and addictive DHTML action game from Brent Silby. Like its name implies, bugs swarm onto the play field single-file, as in the classic arcade game Galaga, and begin infecting solar cells. Protect the cells by shooting the bugs to kill them off. You may also shoot the cells to disinfect them and earn additional points.
Jun 2005
Pong was an amazing and innovative game in its time. Unfortunately, after the novelty wore off there just wasn't much gameplay left to hold our interest. And by today's standards, it's just too simple a game to be much fun anymore. GameLab leverages the simplicity of Pong, as well as that...
May 2005
From Sony Pictures comes these three (3) Flash games from the Kung Fu Hustle movie website, each featuring classic-style videogame pixel graphics and gameplay. Kung Fu Fighter is a simple old-school fighting game that offers special moves and opponents to unlock. You must defeat the opponents the game pits you up...
May 2005
As a tribute to the classic Atari Centipede arcade game from 1980, Emil Korngold has attempted to recreate the game in Flash. The game is still in beta form, and yet his attempt seems to capture much of the action and addictive gameplay of the original. Other than using the mouse...
Jan 2005
A Worm's Life redefines the classic game of Snake and turns it into a fresh new experience. The game features an array of elements that change-up the gameplay formula of the simple arcade game and transforms it into even more addictive, fast action fun.
Jan 2005
While on the topic of Snake, here is a variation of the game for all those who believe snakes should appear, and move in paths, with round edges.
Jan 2005
This version of the classic game of Snake is remarkable in that it comes with source code and a complete tutorial explaining the code by its author, Strille of Sweden. Available on his website, the tutorial is a great way for anyone to get started programming games in Flash. The...
Jan 2005
Brent Silby has created one of the coolest arcade games I have played in a very long time. Think retro-cool as in Galaga, Defender, Centipede and Robotron, and you'll be close to what the action is like in surely one of his best games to date. Replicator captures the essence of arcade action fun and delivers it lovingly in a browser window.
Dec 2004
It shouldn't be surprising that from the world's smallest website comes the world's smallest games. From British game and Web designer Alan Outten comes this very tiny website, only 18 pixels wide by 18 pixels high, yet it is packed full with games such as Pong, Pacman, Footy, Space Invaders, Asteroids, Pinball, and others. Everything old is new again.
Nov 2004
This Mr. Driller clone, created in Flash by Max K., is a decent version of the original game by Namco. Driller uses the arrow keys for movement, and the space bar for drilling. The object is to drill down through the blocks as far as you can without running out of air, or getting crushed. The level of difficulty determines how many rows of blocks y...
Nov 2004
The 1982 classic arcade game of Q*bert, re-created in Shockwave for online play over the Web. The object of the game is to move your Q*bert around the play field, hopping onto each square to turn it to the target color shown. While the default keys to use for movement are U, K, H, and M, the game does allow you to change them to suit your preferenc...
Oct 2004
The classic game of Qix, released by Taito in the arcades back in 1981, and brilliantly reproduced in Flash by Drunk Men Work Here. The objective is to claim portions of the play field by drawing Stix, or block areas, with the cursor marker. This Flash version of the classic game is very close to the original design and captures the essence of the game well.
Oct 2004
XGen Studios is behind this Flash game that is reminiscent of the old-school arcade games Dig Dug and Boulder Dash. Hired to mine the dangerous planet of Mars, you are given a robotic mining pod and sent off on a mission to bring home the Motherload, a fabled cache of rare and valuable minerals. Dig far below the surface of the Earth to earn money for upgrades and find treasure.
Sep 2004
The Curse of Sylvaniah is an action adventure platformer game created in Flash that has a decidedly old-school feel to it. Stylish pixel graphics, sampled sound effects, multiple weapons and a simple targeting system—just point-and-click with the mouse—make this game unique and fun to play. Coding by Mattias Stridsman, graphics by Cyril...
Aug 2004
VirtualApple is a website that boasts over 1100 disk images of Apple II, IIe, and IIgs games and other software. Through the use of an ActiveX application and an Apple IIgs emulator, you can now enjoy Apple II software from years gone by, and do it all online using Microsoft IE and Windows—though, ironically, there is no current support for M...
Jul 2004
I did a double-take when I first saw this on a French Flash games site. Fighters were the one genre that I had seen very little if anything done in Flash, yet now you can relive those arcade glory days by playing Street Fighter with your friends, on your computer. Julien Philippe has created a version that allows you to play single player against ...
Jul 2004
Jun 2004
A version of the original Prince of Persia game recreated in Flash. The original game, created by Jordan Mechner and released in 1989, used an animation technique called rotoscope to give the characters human-like qualities. It was also a lot of fun to play. This special Flash edition isn't quite the whole experience, but you should be able to at least get a taste of what the original was like.
Jun 2004
Written in Flash by Johnny Slack, an interactive multimedia technology student at Purdue, this version of Duck Hunt uses the mouse for aiming and shooting. It looks, acts and sounds just like the original (though it offers only one mode of play).
Jun 2004
Created by Klas Kroon of Sweden, this little game is one of the tiniest Flash games I've ever seen. The objective of Blockdude is to move the little dude to the exit door by picking up and moving blocks to solve each level. This game is actually a remake of an old TI-83 game originally written by Brandon Sterner.
Jun 2004
PsychoPong is not new, as it dates back to 2001; yet it is a worthy game just the same. With gameplay similar to Pong, the granddaddy of all video games, this Shockwave game has a mind of its own. There are five (5) levels of increasing difficulty... though I bet you'll have trouble making it past even the second level. Click. The designer of the ...
Jun 2004
I've been having a lot of fun lately playing this old-school style, top-down shmup (shoot-em-up) called Hurricane developed by Nuvorm in the Netherlands. Along the lines of the arcade classic Galaga, this one has power-ups to increase shields and weapons with lots of cool pyro-technic particle effects. There is also a downloadable PC version of the game available.
May 2004
While on the subject of Pacman, several months ago there was a posting on Slashdot games about a Japanese programmer who re-created Pacman entirely in an Excel spreadsheet. Upon reading the story I was both amazed and curious, so I downloaded the zip file from the site linked-to in the story. And it really was Pacman, right down to the cut scenes b...
May 2004
Another classic game, and this one needs no introduction. Arguably the single game that injected the most excitement into arcade video games during their infancy. Original game: copyright Namco, 1980; this version hand-coded in Flash by Paul Neave.
May 2004
A fantastic Asteroids recreation from Shawn at Hot Flash Games, and boy does it rock! Very authentic classic gameplay with a serious modern soundtrack that just... ROCKS! Shawn did an excellent job designing the sound for the game, as it contains a mix of classic Asteroids samples and some phat rocking beats.
May 2004
This is simply amazing. Someone that goes only by the name of Voxel, has created a 3D version of the original Metroid game in Director! By taking the Metroid tileset, he built a utility that allows him to convert 2D sprites to 3D sprites, and then he uses those to build the levels of the game.
May 2004
Back in the day, Space Invaders, by Japanese company Taito, was one of the coolest games to come along as it was one of the first (if not the first) electronic game ever to offer open-ended gameplay. What that means is that it's impossible to 'beat' the game, the aliens just keep coming at you relentlessly.
Apr 2004
Another favorite of mine is this game by Squid S O U P. Snake delivers classic-style gameplay in a 3D Shockwave implementation. Very nice indeed.
Apr 2004
Bubbels is a strangely addictive Flash game, like Bust-a-Move, from the Netherlands. There are actually five (5) different versions to choose from.


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December 13, 2010
Brad Hoiseth
Saddleback College had one of the top offensive lines in the nation in 2010 and the guy that ran the line up front was a center that was arguably one of the top prospects at his position during the season. He took two trips last week and made a decision to continue his career in the Big 12. ...More... To continue reading this article you must be a member. Sign Up Now!
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As we spend time with the unusual party, it becomes clear that Kafka's wish was for anonymity, and also that he had serious issues with his father. When his parent turns up, he is in possession of a very personal secret relating to his son, one which Kafka is terrified he will disclose.
This is a brilliantly clever, fast-moving dramedy from award-winning Alan Bennett, and the performances of the starry cast are riveting.
© and (P)2004, 2005 BBC Audiobooks LTD
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"Good production - decent play"
This is a good production of Bennett's surreal comedy. There are some good ideas here but ultimately it doesn't quite rank with other Bennett plays.
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Definitions for acanthocephalous
This page provides all possible meanings and translations of the word acanthocephalous
Having a spiny head, as one of the Acanthocephala.
Webster Dictionary
having a spiny head, as one of the Acanthocephala
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October 9, 2004, 09:41 PM
I looking to purchase a walther g22 for plinking. I plan on putting some type of red dot scope on the top rail. Does anybody have any experience with this model? the price I was quoted was $380. Also are there red dots that such as 2x or 4x?


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Kimchigirls' podcast music?
Discuss Korean music.
5 posts • Page 1 of 1
Kimchigirls' podcast music?
Does anyone know how to find out information about the music the Kimchigirls use at the beginning and end of their podcasts? I really like some of it but I have no idea who the performers are or song titles or anything. I'm listening to it right now and I'm so frustrated... Any ideas? (I really like the music from beginner's podcast 10---it sounds like some kind of fusion music with Korean and Western instruments.)
Kimchi Girls' Music?
Unfortunately, I don't receive a reply when I email them. At least one of the emails they list on their web site and in their podcasts is no longer valid. I searched for them on Facebook but don't get a result for "kimchi girls." I'm assuming they aren't active anymore in their podcast venture.
Group - Facebook: http://www.facebook.com/home.php#/group ... 1326420510
Email: firstname.lastname@example.com
As you probably already know, they've released a book for beginner lessons.
Email: firstname.lastname@example.com
As you probably already know, they've released a book for beginner lessons.
I love Korean Pop <3
Kimchi Girls' Music
Thanks so much! The music list was already in their facebook entry! Thanks again!
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Best Use of Turkey (2011)
Court Street Grocers
The classic turkey triple-decker has about as much culinary excitement as the stodgy country clubs where they're so often served. But Court Street Grocers, a specialty grocery and snack shop in Carroll Gardens, has created a sammy that outdoes all those which came before it. The secret? The dark leg meat gets dry-rubbed and cooked in duck fat overnight while the white meat is herb-roasted, resulting in an ultra-moist and flavorful sandwich. Berkshire bacon, lettuce, tomato, and a smear of mayo seal the deal on three thick slices of Orwasher's bread. All you need now is a classic cherry-flavored Cheerwine soda to wash everything down. Oh wait, Court Street Grocers sells that, too. 485 Court Street, Brooklyn, 718-722-7229, courtstreetgrocers.com (11231)
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Brooklyn NY 11231


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Inspired by the Gospel mandates to love, serve and teach, Catholic Charities provides care and services to improve the lives of Marylanders in need.
You Can HelpPlease make your gift today. Every donation counts as we work together to provide care and services to people in need.
Get InvolvedVolunteers are especially needed in our City programs right now. Please volunteer with us to help those in need.
Learn MoreThe Male Involvement Initiative at Head Start "helped me to become a better man."
"I see myself in the people who live here"While coping with the loss of his mother in 2014, Jim Jeppi sought to fill, in part, the void he felt by looking for ways to continue helping older adults. For many years, Jim had been the primary caregiver for his mother, Jennie, who suffered with dementia and other ailments. ... Read more
A Taste of MarylandCelebrate Maryland and Our Daily Bread Employment Center, and enjoy live entertainment, a photo booth, 50/50 raffle, valet parking and much more! Tickets include outstanding and unique cuisine prepared by the top restaurants in Baltimore, with an open bar. ... Read more
Catholic Charities to operate Safe Streets location in Sandtown-WinchesterCatholic Charities of Baltimore will begin operating a new Safe Streets Baltimore program in the Sandtown-Winchester neighborhood of West Baltimore in February, a program designed to reduce shootings and homicides in areas that are disproportionately affected by gun violence. ... Read more


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As a mid-season test, girls volleyball teams from Marcellus and West Geneee both went to the Baldiwnsville Fall Swing Tournament on Oct. 8.
The Mustangs, moving way up in the level of competition, only went 2-4 in Pool C against Burnt Hills, Thomas Edison and City Honors. Marcellus then lost a 23-25, 25-20, 15-11 decision to Fulton in the Silver playoffs.
WG, meanwhile, got put in Pool A with host B'ville, and went 1-5, splitting with Fulton, but swept by the Bees and Queensbury. Moved into the Bronze playoffs, the Wildcats fell to Horseheads 25-15, 25-17.
Marcellus remained unbeaten, though, in the Onondaga High School League, though it got pushed by Fulton Wednesday in a four-set win over the Red Raiders.
They split the first two sets, the Mustangs prevailing 25-22 in the opener and Fulton claiming the second set 25-21. Marcellus cruised to a 25-14 win in the third set and, in the fourth set, held on 25-22 to close things out.
Jessica Cost backed up her 36 assists with four kills and four aces. Nicole Fletcher had 17 kills and nine blocks, while Devon Landers added 13 kills. Tori Bingham added five assists as Brittney Valentine, with 12 digs, and Allie Massara, with seven digs, led the defense.
When WG resumed league play on Tuesday, it took four sets to beat Corcoran 25-7, 25-15, 20-25, 25-21.
Chrstina Holzhauer amassed 13 aces, 17 digs and six kills, while Jackie Harris had seven aces and 16 digs. Liz LaComb had 20 assists and 13 digs, with Emily Shackleton adding 15 digs, matching Jesse Allen's total of five kills. Elle Swete added nine digs.
A wild battle with Cicero-North Syracuse followed on Thursday night. After winning a tight opener 25-23, WG lost the next two sets 25-14 and 25-16, but regrouped to win the fourth set 25-16 before taking a 25-18 defeat to the Northstars in the final set.
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BATON ROUGE, La. (AP) " Republican U.S. Sen. David Vitter survived challenges Saturday from two GOP rivals who called his years-old prostitution scandal a stain on Louisiana, reaching a runoff against Democratic state Rep. John Bel Edwards in the governor's race.
STILLWATER, Okla. (AP) " Lawn chairs, blankets and water bottles were strewn in the street and bodies remained at the scene as Oklahoma State University fans walked past an intersection where a woman had plowed her car into a homecoming parade crowd...
ATLANTA (AP) " Lance Austin ran toward the ball, rolling along at the Georgia Tech end of the field as the final seconds ticked off the clock. He hesitated, a bit confused as his coach screamed for him to leave it alone.
BATON ROUGE, La. (AP) " The latest on elections in which Louisiana voters are making their choice for governor and other statewide races (all times local):
WASHINGTON (AP) " Republican presidential contender Ben Carson is brushing off rival Donald Trump's criticism of him as a "super low energy" candidate.
California this year passed measures to help immigrants in the U.S. illegally by improving their access to health care, opposing discrimination and enabling more people to apply for legal status.
DES MOINES, Iowa (AP) " Bernie Sanders sharpened the contrast with Hillary Rodham Clinton on a bevy of liberal causes on Saturday, casting himself as a principled progressive before thousands of Iowa Democrats in an appearance that could set the...
SALT LAKE CITY (AP) " A New York man is building his own sovereign nation called Zaqistan on a remote piece of land in Utah.
STILLWATER, Okla. (AP) " A woman suspected of driving under the influence plowed into a crowd Saturday during the Oklahoma State University homecoming parade, killing four people " including a 2-year-old boy " and injuring dozens more in a collision...
STILLWATER, Okla. (AP) " The latest on the fatal crash at the Oklahoma State homecoming parade (all times local):
CHAMELA, Mexico (AP) " Just a day after menacing Mexico as one of history's strongest storms, Hurricane Patricia left surprisingly little damage in its wake Saturday and quickly dissipated into a low-pressure system that posed little threat beyond...
Butler County Directory
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On the positive side of its ledger sheet, this bottling delivers a good sense of briary, fairly lively, slightly olive-tinged fruit for a Cabernet of its price, yet, while relatively inexpensive, it is not a wine that is particularly well suited to casual near-term drinking due to its rather imposing tannins. It is well worth the money, but be warned that it needs pairing with hearty foods.
This Cab is pretty good for the price. It's ripe and fruity, with a full body and rich but soft tannins. Turns a bit treacly on the finish, with a dulcet honeyed finish.
Winemaker's Notes "With the 2012 vintage, warm days cooled down by fog in the evenings allowed for the Cabernet Sauvignon grapes to become rich in structure and obtain dark fruit characteristics. We are proud to offer our Cabernet Sauvignon, and hope you also find the rich textures, chocolate finish, and balanced structure as delicious as we do." - Rob Mondavi Jr., 4th Generation Napa Valley Winemaker
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2013 Clos du Val Napa Valley Cabernet Sauvignon
2012 Freemark Abbey Napa Valley Cabernet Sauvignon
2013 Caymus Napa Valley Cabernet Sauvignon (750ml)
2013 Columbia Crest "H3" Horse Heaven Hills Cabernet Sauvignon
2013 Caymus Napa Valley Cabernet Sauvignon (1L)


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Which countertop material is the best choice for your kitchen or bath? Learn the pros and cons of the options as well as which ones are eco-friendly.
Wood Countertop Ideas
recipe box Wood Countertop Ideas Wood countertops are a popular choice ..... the best fit for your countertops . X Walnut Countertop This wood grows dark ..... moisture. Kitchen Island Countertop Wood countertops like this one are easy
Stone Countertop Ideas
matter what kind of countertop you choose, learn ..... tips. How to Clean Countertops Soapstone Sophistication This soapstone countertop beautifully contrasts ..... countertop . Color-Scheme Countertop The color scheme for ..... based off the granite countertops throughout the room
Solid-Surface Countertops 101
bacteria. Watch the video Countertop Choices Solid-surface countertops come in several thicknesses ..... edge. Get quotes for new countertops from professionals in your area. Scribe Countertops The sections of countertop are delivered slightly
Install Kitchen Countertops
and granite countertops . Danny Lipford X Kitchen Countertop Options If ..... possible turn the countertop over and make ..... Plastic Laminate Countertops Plastic laminate ..... Plastic Laminate Countertops When two pieces ..... plastic laminate countertop meet at right
Four Ways to Get the Look of Granite Countertops - Better Homes and Gardens - BHG.com
the Look of Granite Countertops Today's granite-look countertop options have come a ..... your sink into your countertop . Decorative edges ..... individualize your countertop . Pro: Laminate countertops can cost much less
How to Clean Kitchen and Bathroom Countertops
specific types of countertop materials. How to Clean Countertops Granite Countertops ..... sealed. Wood Countertops How to Clean: Wash your wood countertop with a mixture ..... refinish a wood countertop . How to Seal: Oiling wood countertops keeps the wood
Recycled Material Countertops
Recycled Material Countertops Recycled Material Countertops Turn trash into your treasured countertop . Recycled materials ..... Share Selecting a countertop that looks great ..... hoping to craft their countertops from recycled materials
Alternative Countertops
why not an entire countertop hardwood such as ..... ideal for wood countertops ? Smaller pieces ..... manufacture for countertops is thick and crack ..... Concrete is another countertop choice. It can ..... for a concrete countertop as you would a ..... order for concrete countertops to be stain-resistant-Next to cabinets, countertops do more than any other element to define your kitchen. Plus, you use them everyday. So be sure to consider all your options before making a final choice. I'm Lacey Howard. Let's take a look at all the distinctive countertop options you have to choose from---- Tile, metal, wood, glass and concrete. Tile comes in many shapes, colors, finishes and sizes. You're sure to find something that fits your style and your budget. -Tile is heat resistant and can be installed in custom patterns. In fact, a practice do it yourself or can tile a backsplash or a countertop . Just make sure to use a quality wood saw and thoroughly seal the surface after installation. -Be aware that grout lines between tiles can stain easily and yellow over time. It helps to choose a darker tinted grout. Re-grouting every few years will likely be necessary. -Tile can chip but just replace individual tiles as needed. -Look for vitreous tile. It's harder and denser and will stand up better to the demands of the kitchen. Metal countertops such as stainless steel or copper can give your kitchen a restaurant or industrial feel. -Make sure to choose metal countertops that are stain and scorch proof. -And realize that scratches and fingerprints will show on metal until it mellows and develops the surface patina a year-long process. Wood is a great surface for cutting boards, so why not an entire countertop hardwood such as maple, beach and bamboo are ideal for wood countertops ? Smaller pieces of hardwood are alt-impressed and glued together to form butcher block. Wood is great for an island or as an inset next to a sink. The surface is forgiving on small cuts. Wood countertops benefit from an application of mineral oil every 4 to 8 weeks. Glass is gaining a presence in kitchens. It's often used as an accent such as a snack bar or serving ledge. Glass manufacture for countertops is thick and crack resistant. Concrete is another countertop choice. It can be tinted and sculpted and you can mix in small stones and other particles for a variety of looks. Concrete countertops are created, polished and sealed onsite. A project best left to the professionals. You'll pay just about as much for a concrete countertop as you would a stone one. In order for concrete countertops to be stain-resistant, they must be sealed initially and again in every few years. They can crack and be difficult to replace or repair, but they are unique option that weather to a beautiful patina and can be any color, shape or texture you wish. Check out these options. All these services take a bit of care and upkeep. Ask a professional about cleaning, filling and maintenance, and knowing your countertop is going to show wear over time, but don't fight it. Embrace the beautiful natural patina of a well-used countertop .
Eco-Friendly Countertop Guide - Better Homes and Gardens - BHG.com
an eco-friendly countertop the right surface ..... constitutes a 'green' countertop ?" Green countertops are those manufactured ..... the gamut for green countertop materials. Bamboo and recycled-paper countertops are on the low end
White Kitchen Countertops
more expensive countertop options. Conversely ..... engineered countertops offer a wide ..... one type of countertop ? Mix-and-match countertops are an emerging ..... the exterior countertops and dark granite ..... chosen the countertop material and


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Hotels around
Neuenburg am Rhein
Hotel Krone Quick description Featuring breakfast served in bed, individually furnished...
Neuenburg am Rhein
Hotel Weisses Kreuz Quick description A traditional tavern, wine estate and on-site distillery are...
Neuenburg am Rhein
Neuenburg am Rhein
Hotel-Zähringerstube Quick description Centrally located in the Old Town, this hotel in the town of...
Neuenburg am Rhein
Hotel am Stadthaus Quick description This quietly located, 3-star in Neuenburg offers views of the...
Neuenburg am Rhein
Hotel Anika Quick description Set in the town of Neuenburg am Rhein, Hotel Anika offers...
Hotel Restaurant De La Poste Quick description The charming 3-star Hotel Restaurant De La Poste welcomes you...
Hotel Bären Quick description Offering a la carte restaurant, 300 year old Hotel Bären is...
Hotel zur Krone Quick description This 3-star hotel in the wine-growing village of Auggen...
Landhotel Alte Post Hotel information The hotel offers entertaining cooking lessons. Appealing...
Hotel Touristik
|Hotel Touristik
|Basler Str. 2
|79395 Neuenburg am Rhein
|show map
The family-run Hotel Touristik is located 1 km from the River Rhine in Neuenburg, close to the Swiss and French borders. Just 600 metres from the A5 motorway, it offers free WiFi in all areas and free parking with video surveillance. The air-conditioned, non-smoking rooms at Hotel Touristik Neuenburg include a flat-screen TV, seating area, a desk and tea/coffee facilities. The modern bathroom comes with a shower and hairdryer. A rich buffet is served every morning in the breakfast room, and a number of restaurants can be found within a 5-minute walk away. At the hotel, guests can also enjoy a selection of wines from the surrounding region.
Important information
Guests arriving outside reception opening hours are kindly asked to contact the hotel in advance. Contact details can be found on the booking confirmation. Late arrivals can be accommodated after 22:00 if guests contact the hotel before 22:00 to receive the key code. Please note that guests found to be smoking in the hotel may be subject to an extra cleaning fee.
Photo album
Featuring free WiFi throughout the property, Hotel Touristik offers accommodation in Neuenburg am Rhein. Free private parking is available on site. Each room comes with a flat-screen TV with satellite channels. Some units feature a seating area for your convenience. Every room is fitted with a private bathroom. A TV is available. There is a cash machine at the property. Colmar is 33 km from Hotel Touristik, while Basel is 29 km away.
Points of interest
|Neuenburg am Rhein
|2 km
|Neuenburg am Rhein Hotel Krone
|14 km
|Kandern swimming pool
|20 km
|Oberrimsingen Guggemusik
|24 km
|Lörrach indoor swimming pool
|Breisach am Rhein
|24 km
|Breisach am Rhein Hotels
|Freiburg im Breisgau
|30 km
|Freiburg im Breisgau tourism
|40 km
|Teningen Black Forest


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Published on the Packaging World Web site
Controls Product Brief
| September 12, 2011
Banner Engineering Corp.: Indicator light with audible alarm
Designed for washdown environments, the K50L Sealed Audible EZ-LIGHT™ from Banner Engineering is a rugged, cost-effective and easy-to-install indicator light with an audible alarm, which allows it to be easily seen and heard from a distance.
Featuring a fully sealed body, rated IP67 or IP69K depending on the model,the K50L is suitable for use in the food and beverage industry and processing lines. With a wide, 12-30V dc operating range, the K50L is also suitable for use in mobile equipment. The compact device is completely self-contained, requiring no controller for operation. This eliminates the need for wires, allowing the K50L to be easily installed in virtually any location. It is immune to EMI and RFI interference and is available in 1-, 2- and 3-color models with green, red and yellow LEDs.
Companies in this article:
Banner Engineering Corp.


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Home > News > World News
Hollande to quicken tax-cutting offer implementation
Posted on Jan 22 2014 | IANS
Paris, Jan 22 : French President Francois Hollande Tuesday said his government will put on the ground his tax-cutting offer to companies during an economic conference in the spring.
"The agreement should be concluded with firms during a great social and economic conference in the spring," Xinhua quoted Hollande as saying while detailing the schedule of his "responsibility pact" to tackle unemployment.
He reiterated the government's pledges to not increase tax on households and to cut public spending.
Last week, Hollande announced the end of tax on employers that subsidise families by 2017, which will contribute to the decrease of labour costs by 30 billion euros (about USD 40 billion).
During his New Year Greetings message to the country's business leaders, Hollande called on companies to respect their commitment mainly over "the number of created jobs, primarily for youth... through the development of training and generations contracts".
He also asked companies to focus on improving "the quality of jobs through employee training, improving classification grids and reducing the precariousness of work."
With an unemployment rate expected at 11 percent in mid-2014, the ruling Socialists eyed creating 1.8 million new posts by implementing the "responsibility pact" over next five years.


text: [[quoteright:300:http://static.tvtropes.org/pmwiki/pub/images/woee2_9947.png]]''Witches Of East End'' is a 2013 [[FeministFantasy supernatural drama series]] on the [[{{Creator/Lifetime}} Lifetime Network]] based [[TheFilmOfTheBook on the book]] of the same name by Melissa De La Cruz.Joanna Beauchamp is your average middle-aged art teacher, a single mother with two grown daughters, Ingrid and Freya. Except that she is immortal, her estranged sister Wendy can turn into a cat and has nine lives, and Ingrid and Freya have died and been reborn multiple times over the past few centuries – and all four of them are secretly witches.After growing tired of constantly seeing her daughters be killed by their own magic, Joanna has decided to raise Ingrid and Freya without knowledge of their witchcraft to hopefully see them live past 30 this time. But when a shapeshifter who looks exactly like Joanna targets their whole family, Wendy convinces her that they can't hide Ingrid and Freya's heritage from them anymore.----!!This series provides examples of:* AbsoluteCleavage: Archibald's courtesan wears a dress cut to the navel, cementing his status as a satanist/occultist in the 19th century. The big ol' orgy he's throwing when we meet him helps, too.* AllWitchesHaveCats: Subverted with Wendy.* AmoralAttorney: Harrison is implied to be one.* AsYouKnow: In the very first episode, Ingrid informs Freya that she's engaged to Dash, and Joanna gives Wendy a detailed explanation of how her curse and the girls' BornAgainImmortality works.* BurnTheWitch: In some of Joanna's flashbacks, it's shown that her daughters were burned as witches in earlier eras. * CatsAreMagic: The black cat in the first episode has a neat trick...* ClearMyName: The shapeshifter manages to frame Joanna for the murder of a man by killing him in front of his wife while looking like Joanna. It's up to Joanna and Harrison to try to prove that Joanna didn't do it.* CoffinContraband: As an immortal witch who needs to switch identities every few decades so people don't notice that she doesn't age, Joanna fakes the death of her old identity and then moves to a new city to start fresh. When she moves back to a town where she used to live a century earlier, she digs up the empty grave and stores an emergency stash of money in the coffin. Later on she also uses the grave to store a cursed painting.* DisappearedDad: Ingrid and Freya's father isn't mentioned until [=S01E08=], when it's stated he's been gone for ''over a century'', making this an extreme case. Due to their {{born again immortality}} Ingrid and Freya have never seen him before in their present lives, nor in most of their past ones going back centuries. Perhaps unsurprisingly, Ingrid is bitter with him over this, although Freya warms up more quickly. It's somewhat different because Joanna asked him to leave, and thus he's upset that she told his daughters he'd abandoned them.* DoubleStandardRapeSciFi: Eva uses a LovePotion on Killian so she can have sex with him as much as possible in order to [[spoiler: have a baby]], yet when everything is out in the open [[spoiler: her death scene]] is rendered as a poignant moment where the audience is meant to sympathize with her - both Freya and Killian himself are visibly moved, and he shows no emotional trauma from the abuse. The indignation of the other characters seems to stem from Eva coercing Killian's love and taking him from Freya, with no mention of forced sex.** Ingrid's trance state with the mandragora. This results in horror and a mini-breakdown for Ingrid, but the rest of the cast utter 'oh noes' more akin to 'what a shame' than as if she had suffered a terrible ordeal.* EquivalentExchange: Magic isn't "free", it has to come from somewhere. When Ingrid casts a spell to bring a loved one back to life, she learns that at some point in the future she will lose someone she loves. * GeometricMagic: Pentagrams and other forms and symbols are part of successfully practicing witchcraft.* HotWitch: Within the boundaries of beauty being in the eye of the beholder, most of the main cast.* IdenticalGrandson: In the first episode, Ingrid is seriously weirded out on finding a photo of one of her earlier, much earlier, incarnations. This is before we the audience know the truth, so we don't know what the hell's going on before the photo is destroyed.* {{Immortality}}: It's unclear whether or not all witches are immortal or if Wendy and Joanna have been specifically cursed to be immortal. Their immortality certainly works differently. Joanna is [[NighInvulnerability near-impossible to kill]]. Wendy dies like anyone else, but [[ResurrectiveImmortality comes to life]] a few hours after she dies. Ingrid and Freya die like anyone would, but almost as soon as they do Joanna [[BornAgainImmortality gets pregnant]] with Ingrid and the cycle starts over.* {{Masquerade}}: The very first thing Ingrid and Freya learn about being a witch is that they must never tell anyone about it.* MindRape: Wendy essentially destroys Maura's mind as a side effect of the [[LaserGuidedAmnesia memory spell]] cast on her, resulting in her being institutionalized for terrifying delusions.* NoodleIncident: There are several mentions or brief flashes to past experiences of Joanna and her family which have as of yet only vaguely been explained.** There's a sequence in [=S01E03=] where Joanna pulls a flask, a gun, and a hammer out of a box, and then flashes back to the enemies she defeated using each of them without context as to who those people are.** Wendy mentions in passing how she once died by being eaten by an alligator. And once from syphilis.* OohMeAccentsSlipping: Julia Ormond's native English accent comes out frequently. * OurGhostsAreDifferent: They can touch people who can see them (aka witches), they can affect electricity, and if they stick around on Earth for too long they'll remain stuck there.* PhantomZonePicture: One of Freya's ex-boyfriends from a past life is trapped in a painting. He escapes in [=S01E01=] and tries to do the same to Freya, but is eventually trapped in another painting. And apparently he's not the only person the witches got rid of that way.* ReincarnationRomance: [[spoiler: Killian and Freya.]]* RoaringRampageOfRevenge: The guy trapped in the painting in the first episode goes on one against Freya when he gets out.* ShapeshiftingExcludesClothing: The reason why Wendy ends up naked a couple of times when she turns into a cat and back into her human form again.* ShirtlessScene: Freddie Prinze Jr. gets one in the fourth episode. Wendy spends a moment EatingTheEyeCandy before deciding that, no, she's not going to leave so soon.* SkepticismFailure: Ingrid spends the first episode declaring herself a "rational skeptic" who doesn't believe in witchcraft, until of course she's then proven ''completely'' wrong.* SpookyPainting. A guy in a painting suddenly starts to move. See PhantomZonePicture above.* StalkerShrine: As shown is [=S01E03=], the shapeshifter has one filled with pictures of Joanna.* TarotTroubles: The witches lay the cards a couple of times. It's how they find out that a shapeshifter is out to kill Joanna and her daughters. Even shuffling the deck and trying it over dozens of times doesn't change the message of the cards.* UnwantedRevival: In [=S01E02=] Ingrid doesn't know yet that Wendy will come back to life a few hours after being stabbed to death by the shapeshifter, and uses a spell to resurrect her. Wendy is less than pleased about it and informs Ingrid that sooner or later she'll have to pay the price by losing someone she loves.* WitchSpecies: Witchcraft is genetic. A passing comment by Joanna reveals for the first time that she and Wendy are from [[spoiler:Asgard]].


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