text:
Lori Copeland On The Secular Vs. Christian Book Market
Penning an assortment of titles from historical to contemporary romance, Lori Copeland is an established author in both the secular and inspirational markets. Today, she shares how writers can decide which market best suits their work, and how you know when crafting Christian fiction is right for you.
Many of you remember the name Lori Copeland from the secular market. Hi again! I'm still writing my fun, lighthearted romances in the Christian market now. My newest releases are The One Who Waits for Me and a co-authored book with Virginia Smith, Lost Melody. I am asked so many questions about why I chose to switch markets? The answer was very simple; I wanted to write stories that reflected my faith walk, whether it is in secular or Christian market. The Christian market is often overlooked or thought to be preachy by those who want a secular book with secular content. For the writer who thinks they want to write in the Christian market, I have some bits of well-intentioned advice.
A writer does not choose the Christian market; it chooses him/her.
If you long to push the envelope, you will most likely not be best suited for the Christian market.
If want to encourage the struggling Christian in his faith walk, you'll fit in nicely.
If you feel that your story needs to be told with graphic love scenes and language you will need to write in the secular market.
If you have a heart for providing reading material to a specific genre, one that has a smaller (though growing by leaps and bounds) audience and print-runs (in most cases) you'll be happy in the Christian market.
Writing in the Christian genre means one thing; you are willing and eager to share your faith through your stories with the reader who is looking for books that they can read with their daughters, clean stories that reflect the Christian walk. It's a genre. It's meant to lead the reader to the stories of their choice.
When asked what's been the hardest about my making the switch from secular to Christian? It's losing contact with some of my most valued friends in the secular industry. Genre writing is the same throughout the publishing world; you write mystery, romance, thrillers, cozies, contemporary and historical. You make the choice of where your stories fit, and mine always fit best on the squeaky clean side. Since an article or blog leaves room for speculation on intent, let me clarify. Neither I nor any other Christian writer feels above another writer. We do not set ourselves aside as preachy examples of sainthood, far from it. If you only knew some of us! Speaking solely for myself, I realized after years of publishing, exactly where my stories fit best. An author does themselves no service if they are trying to write material that doesn't come natural to them. For me, writing love scenes and language was the most difficult part of my work, and no, I'm not a prude. Like others in my genre, I'm a hard working author struggling to write stories that appeal to a specific audience.
So, I hope to see a lot of you around in the next coming year. I've decided there's not a single thing that divides authors other than the genre they're writing in.
For more inspirational news and coverage, visit our Everything Inspirational Page. And don't forget, we're spotlighting inspirational reads all month long!


text:
After racking up huge debts on the Romaso gold mine Scott and George test out a new claim; George risks it all in a dangerous gold hustle.
George is called home to fight a lawsuit. leaving Scott in charge; Chinese neighbors threaten the borders.
A gold-mining dream drives Scott and George further into debt; relationships with mining partners are strained.
Top TV Shows |
All TV Shows |
Your Favorite Movies |
Privacy Policy |
License Our Content | Media Kit | About Us | © 2015 TMS | Zap2it TV Listings

subset: commoncrawl


text:
Mosquitoes are probably the most common and overbearing insect nuisances during the summer months. Because they can carry serious illness-causing pathogens, such as West Nile Virus, a repellent should be used when outdoors during summer. Mosquitoes are attracted to warmth, moisture, the odor of your skin and even carbon dioxide that your body gives off. Insect repellents provide a barrier around you that they don't find appealing.
Mosquitoes are most active in the evening hours and love areas with standing water: stagnant puddles and ponds, birdbaths, gutters, etc. If you find yourself outdoors near these areas, particularly in the evening, use a repellent to protect yourself. This doesn't mean that you're safe from the bugs in broad daylight. If you notice them buzzing around you, use some repellent, no matter the time of day.
There are a number of repellents from which to choose. Sprays and lotions that you apply to exposed skin and/or clothing are most effective in densely insect-populated areas. There are also citronella candles, mosquito coils and electronic devices, among other deterrents that are well-suited for backyard barbeques. You just need to choose which type is most effective for your situation.


text:
Respond to Review of Ajdovo Zrno
by hokusai77
Review: I happened to be there on my first night in Ljubljana too late (restaurant closes at 7 pm), but I had the chance to try it out the next day. It's a simple cafe with limited choice, but price/quality ratio is extremely high. I had a nice salad from the salad bar (you can choose among plenty of options, dried vegetables are awesome), and a hearty veggie stew with homemade bread (the other option as main dish for vegans was a mushroom cake).
You must login to post a response
Login | Register (see member benefits)
Login | Register (see member benefits)


text:
Treasury Yields Only Turn Attractive at 3.5%, JPMorgan Says
U.S., German and U.K. government-bond yields are too low to be attractive given the outlook for improving global growth, according to JPMorgan Asset Management.
Treasury 10-year notes should yield 3.50 percent based on growth and inflation forecasts and the impact of the Federal Reserve's asset purchases, instead of today's 2.78 percent, JPMorgan executives said in a presentation in London. Yields on German bunds and U.K. gilts also should be higher, they said. T. Rowe Price sees U.S. 10-year yields rising more slowly than some investors expected, officials said at a separate event.
"We still can't get too excited about government bonds," said Iain Stealey, a portfolio manager for JPMorgan's international fixed-income group. "If gilt yields or Treasury yields wax and wane, you can still lose a little bit of money owning government bonds. We don't see there to be much opportunity there."
The benchmark Treasury yield climbed to this year's high of 3.01 percent on Sept. 6, from as low as 1.61 percent in May, as signs that the world's largest economy is gaining momentum fueled bets the Fed is moving toward reducing its $85 billion a month in asset purchases. The yield was last at 3.50 percent in April 2011.
Treasuries have lost investors 2.5 percent this year after returning 2 percent in 2012 and gaining 10 percent in 2011, according to Bloomberg World Bond Indexes. Gilts dropped 3.6 percent and German securities fell 1.2 percent in 2013.
'Low' Yields
"People want fixed income that can potentially give them some sort of return, and government bonds used to do that," said Nick Gartside, international chief investment officer for fixed-income at New York-based JPMorgan, which manages $1.5 trillion. "What we're seeing from institutional investors is they want a source of fixed income that can potentially give them a return, which clearly with low government-bond yields and low corporate-bond yields is a stretch."
German 10-year bund yields should be at 2.20 percent, versus 1.73 percent today, while similar-maturity U.K. gilts should yield 3.30 percent instead of 2.82 percent, JPMorgan executives said.
The company bases its estimate for where the Treasury 10-year yield should be on a 2014 growth forecast of 2.6 percent and inflation prediction of 1.9 percent, and a reduction of 1 percentage point due to the impact of the Fed's debt-purchase program known as quantitative easing.
Gradual Transition
While bond yields will rise in scenarios where the economy continues to grow, "the transition from this 30-year bull market will be more gradual than some people had initially feared with the tapering comments we saw earlier" from the Fed, Michael Gitlin, head of fixed income at T. Rowe Price Associates Inc., said today at a media presentation in New York.
T. Rowe Price forecasts that the 10-year yield will rise to 3.25 percent by the end of 2014 as the economy recovers at a pace that is likely to be "average at best," Gitlin said.
The Fed will probably reduce its purchases in the next few months even if the pace of economic growth is somewhat slower than most investors expect, the Baltimore-based executive said.
While benchmark yields will probably increase next year, "there are some opportunities out there," Gitlin said.
Emerging-market corporate bonds, which have fallen less than sovereign debt this year, offer opportunities next year, particularly lower-rated securities, he said. In the U.S., high-yield debt and bank loans offer the opportunity for positive returns, he said.
"The market is still rewarding the lowest credit-quality credits in this environment," Gitlin said.
'Good' Rotation
Even as about $130 billion left fixed-income funds and exchange-traded funds since May, only $60 billion of that went into equity portfolios, with $70 billion heading for money-market accounts, Gitlin said. That makes the rotation out of bonds and into stocks "a mildly good one" that will continue at a muted pace in 2014, he said.
That contrasts with the "Great Rotation" of assets away from safe holdings such as Treasuries and into riskier securities forecast by many strategists earlier this year.
Demand for longer-maturity securities will come from insurance companies and pension funds as they move to narrow the gap between their liabilities and their assets, while individuals will continue to put some money in bonds, he said.
"After two generational bear markets in equities in one decade, folks are more in tune with having balanced portfolios," Gitlin said.
T. Rowe Price managed $647.2 billion as of Sept. 30.
"The fear of rates going a lot higher is misplaced," Gitlin said. "The economy is going to be average; good enough for rates to go up a little bit, but not much."


text:
Diversified Financial Services
Company Overview of Conrad N. Hilton Foundation Inc.
BOARD MEMBERS AFFILIATED WITH Conrad N. Hilton III*
MOST CONNECTED PEOPLE TO Conrad N. Hilton III
|Eric M. Hilton
|31 Relationships
|Barron Hilton
|7 Relationships
|Gregory R. Dillon
|7 Relationships
|James R. Galbraith
|7 Relationships
|Robert Buckley
|7 Relationships
Sponsored Financial Commentaries
Sponsored Links
Only a company representative may request an update for the company profile. Documentation will be required.
To contact Conrad N. Hilton Foundation Inc., please visit . Company data is provided by Capital IQ. Please use this form to report any data issues.
Our data partners will research the update request and update the information on this page if necessary. Research and follow-up could take several weeks. If you have questions, you can contact them at firstname.lastname@example.com.


text:
Acoustic Du Jour
Bands on the Verge
HTZ-FM Mobile App
Music News
Music Blog
Recently Played
Rocksearch 2015 Winner
Request A Song
Rocksearch 2015 Winners
Contest Rules
Prize Pickup
Show Schedule
All Blogs
Biggs & Barr
Jesse Modz
Brittany Anastacio
Nikki Sixx
Paulie Morris
Pastey Jamie
Inappropriate Grant
B&B Homemade Christmas
Biggs & Barr Podcast
Biggs & Barr-Barians
Girls on Games
Green Bay Prank Calls
Photo Gallery
Rocksearch 2015 Winners
The Advisors
Concert Listings
Event Listings
Help Kids Shine
Search for
Kudos (UK)
Pop/Rock, British Invasion, Contemporary Pop/Rock, AM Pop
Share This
Album Review
This album, which kicked around the American London Records catalog and record store browsers for decades, also fooled a couple of generations of the band's fans. This is
the Moody Blues
, to be sure, but it is the work of the original R&B-based lineup featuring
Denny Laine
on lead vocals and guitar, and
Clint Warwick
on bass, along with
Mike Pinder
(piano, organ),
Ray Thomas
(harmonica, vocals), and Graham Edge (drums), who enjoyed a monster international hit with the R&B-style single "Go Now" in 1964. A lot of what's here is very good in that vein, from
James Brown
-authored soul-shouters to blues by
Willie Dixon
Sonny Boy Williamson II
, to the smoother, more Motown-like work like the exquisite "I Had a Dream" (co-written by
Ellie Greenwich
). But with the exception of "From the Bottom of My Heart" -- arguably the best unsuccessful single of the whole British Invasion -- which was a much more advanced single, and achieved some interesting timbral and dramatic effects within a soul framework, nothing here remotely resembles even the most rudimentary psychedelic sounds for which the band was known after 1966. For most fans of the latter, this is more an interesting artifact than anything else, though listeners who love the sounds of the British Invasion circa 1964 and 1965, especially the work of
the Animals
the Rolling Stones
, and
the Zombies
, may find a lot to enjoy here. They should also be aware, however, that on LP this album was supplanted by the late-'70s English double-LP compilation
A Dream
, and on CD there are fuller collections of the group's work from this era, mostly built around the equivalent U.K. album title
Magnificent Moodies
(which, in its original LP version, is less desirable than this album, as it doesn't contain "From the Bottom of My Heart").
Bruce Eder, Rovi
Track Listing
I Go Crazy
And My Baby's Gone
Go Now
It's Easy Child
Can't Nobody Love You
I Had a Dream
Let Me Go
I Don't Want to Go on Without You
True Story
It Ain't Necessarily So
Bye Bye Bird
From the Bottom of My Heart (I Love You)
Contact Us
Advertise With Us
Prize Pickup
Contest Rules
The HTZ PIT
Web Related Inquiries
Copyright © 2016. All rights reserved.


text:
It's normally someone asking for something
Best Answer
oops, the rabbit died.....
Best Answer
it was a metaphor for when your girl friend calls and tells you she is pregnant...
Best Answer
It's probably a disgusting ring tone.

Change it.
Best Answer
Do you have children?
Best Answer
ok then, we can eliminate that reason : )
Best Answer
Because it's an annoying device! Lol
Best Answer
Best Answer
Related Questions
Have you ever received good news from a 3 am phone call? It's usually not good when your phone rings at the time ?KerriJ1970 41-45, F 8 Answers 2 Aug 6, 2013 in Community
KerriJ1970 41-45, F 7 Answers 2 Nov 25, 2013 in Embarrassing & Funny
*phone rings* Me: *runs marathon, swims Atlantic ocean, crosses lions Den, swings on vines, back flips. *phone stops -_-CindereIIa 18-21, F 3 Answers 1 Sep 17, 2014 in Community
Do you hate when a phone rings when you have the surround sound on? I always think it's my phone. :PKerriJ1970 41-45, F 4 Answers 2 Feb 16, 2015 in Embarrassing & Funny
don't you hate it in movies when the phone rings and they take forever to answer it,ahhhhhh ! answer the phone dumb @ss!
spacedollfin 13-15, F 4 Answers 2 Jun 1, 2015 in Art
LadyBrighid 51-55 19 Answers 1 Aug 18, 2009
i know i do and dog tired i answer it instead of letting the machine get it. When it is not an emergency i am peeved then plop back down to snoring. what about u?typoquene 41-45, F 8 Answers 1 Mar 10, 2010
suan 51-55, F 10 Answers 1 Jun 12, 2010


text:
Tags: amazing, long, leg, blonde, lary, shopping, shoes, but, ends, pussy, rocked, hard, against, couch, store, clerk, babes, feet
Submited: 6 years old
Views: 4238
Copyright © 2006 - 2016 DeviantClip.com - All Rights Reserved.
Support / Contact
Webmasters Area
Site Map
All actors and models appearing on this website are 18 years or older.
Section 2257
Amazing long leg blonde lary was shopping for shoes but ends up getting her pussy rocked hard against the couch by the store clerk


text:
To make reservations by phone, call 1-800-321-2211 in the USA and Canada (or any of our worldwide reservation telephone numbers).
It Pays to Book Direct™
It Pays to Book Direct™
9300 SE Sunnybrook Blvd.
Clackamas, Oregon 97015
Featuring Microsoft Bing Maps technology.
Portland International Airport - PDX
Airport Phone: +1 503 285 9369
Hotel direction: 13 miles S
This hotel does not provide shuttle service.
I-205 South to exit #14 (Sunnyside Rd). Continue straight onto Sunnybrook Boulevard, turn right on Sunnybrook Boulevard, first left at light onto 93rd.


text:
Quite simply, the East Syracuse-Minoa football team is in the midst of the most successful run in the program's history.
In the last three seasons, the Spartans have gone 23-6, squeezing in a Section III Class A title in 2006 and laying claim to three consecutive league championships.
Head coach Kevin DeParde said two primary factors are responsible for this upturn. First, he cited the team's strength and conditioning program, which got a boost when a state-of-the-art weight room opened a few years ago.
Second, DeParde said that the team's success has brought out more multi-sport athletes. Indeed, it's rare to find a key ESM player that doesn't play some other varsity sport.
Participation numbers have soared past triple figures -- 45 this year on the varsity, 55 with the JV team. And the returning players come back hungry.
After going 6-1 in the '07 regular season, ESM, at home, got off to a terrible start in its first-round playoff game against New Hartford and took a 20-14 loss. DeParde said his team played its "worst 10 minutes of the season" in the first quarter and paid the price for it despite a spirited comeback.
On offense, the Spartans in 2008 will primarily need to make sure the big yardage numbers posted by departed senior running back Matt Cushing do not decrease.
To make up for it, ESM will rely on a deeper pool of backs. Dustin Moss, a first-rate wrestler (he won a gold medal at the Empire State Games in Binghamton earlier this summer), could fill either spot, while Jaquan Williams, Ken Cannon and Jacob Curtis are likely to take turns carrying the ball, too.
Also, DeParde needed to replace his quarterback. Ben Kreischer, a senior, has been handed the task of succeeding Matt Letcher. Already a starting linebacker, Kriescher, at 6-0 and 185 pounds, is equally capable of throwing deep downfield and taking off to run.
(Continued on Next Page)
Prev Next
More like this story
Use the comment form below to begin a discussion about this content.


text:
Are you Curtis J Omiecinski?Claim your profile
Publications (127)460.46 Total impact
Article: Δ9-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: Possible involvement of induced levels of PPARα in MDA-MB-231 breast cancer cells[Show abstract] [Hide abstract]
ABSTRACT: We recently reported that 9-tetrahydrocannabinol (9-THC), a major cannabinoid component in Cannabis Sativa (marijuana), significantly stimulated the expression of fatty acid 2-hydroxylase (FA2H) in human breast cancer MDA-MB-231 cells. Peroxisome proliferator-activated receptor (PPAR) was previously implicated in this induction. However, the mechanisms mediating this induction have not been elucidated in detail. We performed a DNA microarray analysis of 9-THC-treated samples and showed the selective up-regulation of the PPAR isoform coupled with the induction of FA2H over the other isoforms ( and ). 9-THC itself had no binding/activation potential to/on PPAR, and palmitic acid (PA), a PPAR ligand, exhibited no stimulatory effects on FA2H in MDA-MB-231 cells; thus, we hypothesized that the levels of PPAR induced were involved in the 9-THC-mediated increase in FA2H. In support of this hypothesis, we herein demonstrated that i) 9-THC activated the basal transcriptional activity of PPAR in a concentration-dependent manner, ii) the concomitant up-regulation of PPAR/FA2H was caused by 9-THC, iii) PA could activate PPAR after the PPAR expression plasmid was introduced, and iv) the 9-THC-induced up-regulation of FA2H was further stimulated by the co-treatment with L-663,536 (a known PPAR inducer). Taken together, these results support the concept that the induced levels of PPAR may be involved in the 9-THC up-regulation of FA2H in MDA-MB-231 cells.
Article: Phenobarbital and Propiconazole Toxicogenomic Profiles in Mice Show Major Similarities Consistent with the Key Role that Constitutive Androstane Receptor (CAR) Activation Plays in their Mode of Action[Show abstract] [Hide abstract]
ABSTRACT: Toxicogenomics (TGx) is employed frequently to investigate underlying molecular mechanisms of the compound of interest and, thus, has become an aid to mode of action determination. However, the results and interpretation of a TGx dataset are influenced by the experimental design and methods of analysis employed. This article describes an evaluation and reanalysis, by two independent laboratories, of previously published TGx mouse liver microarray data for a triazole fungicide, propiconazole (PPZ), and the anticonvulsant drug phenobarbital (PB). Propiconazole produced an increase incidence of liver tumors in male CD-1 mice only at a dose that exceeded the maximum tolerated dose (2500 ppm). Firstly, we illustrate how experimental design differences between two in vivo studies with PPZ and PB may impact the comparisons of TGx results. Secondly, we demonstrate that different researchers using different pathway analysis tools can come to different conclusions on specific mechanistic pathways, even when using the same datasets. Finally, despite these differences the results across three different analyses also show a striking degree of similarity observed for PPZ and PB treated livers when the expression data are viewed as major signalling pathways and cell processes affected. Additional studies described here show that the postulated key event of hepatocellular proliferation was observed in CD-1 mice for both PPZ and PB, and that PPZ is also a potent activator of the mouse CAR nuclear receptor. Thus, with regard to the events which are hallmarks of CAR-induced effects that are key events in the mode of action (MOA) of mouse liver carcinogenesis with PB, PPZ-induced tumours can be viewed as being promoted by a similar PB-like CAR-dependent MOA.
Article: Intronic DNA elements regulate Nrf-2 chemical responsiveness of the human microsomal epoxide hydrolase gene (EPHX1) through a far upstream alternative promoter[Show abstract] [Hide abstract]
ABSTRACT: In humans, microsomal epoxide hydrolase (mEH) contributes important biological functions that underlie both detoxification and bioactivation fates arising from exposures to foreign chemicals. Previously, we discovered that human mEH gene transcription is initiated from alternative promoters. The respective transcripts are programmed with tissue specificity and the upstream E1b promoter contributes predominantly to mEH expression. The results presented demonstrate that exposures to the Nrf2 activators, sulforaphane (SFN) and tert-butylhydroquinone (tBHQ), markedly activate E1b transcription in human lung and liver cells. Genomic analyses identified two major DNase I hypersensitive regions (HS-1 and HS-2) within the ~ 15 kb intervening sequence separating E1b from the downstream E1 promoter. In BEAS-2B cells, the Nrf2 effectors, SFN and tBHQ, selectively activated the more distal HS-2 through an antioxidant-response element (ARE). An activator protein 1/12-O-tetradecanoylphorbol-13-acetate interaction was further identified within the HS-2 enhancer that functioned to additionally contribute to ARE-mediated induction responsiveness of the E1b promoter. The results demonstrate that ARE modulation, integrated with additional transcriptional complexes, regulates the tissue-specific expression of mEH and that these processes likely coordinate both the protective and bioactivation functions contributed by mEH activities in human tissues.
- [Show abstract] [Hide abstract]
ABSTRACT: Polychlorinated biphenyls (PCBs) are persistent environmental toxicants, present in 100% of US adults and dose-dependently associated with obesity and non-alcoholic fatty liver disease (NAFLD). PCBs are predicted to interact with receptors previously implicated in xenobiotic/energy metabolism and NAFLD. These receptors include the aryl hydrocarbon receptor (AhR), pregnane xenobiotic receptor (PXR), constitutive androstane receptor (CAR), peroxisome proliferator-activated receptors (PPARs), liver-X-receptor (LXRα) and farnesoid-X-receptor (FXR). This study evaluates Aroclor 1260, a PCB mixture with congener composition mimicking that of human adipose tissue, and selected congeners, as potential ligands for these receptors utilizing human hepatoma-derived (HepG2) and primate-derived (COS-1) cell lines, and primary human hepatocytes. Aroclor 1260 (20 μg/mL) activated AhR, and PCB 126, a minor component, was a potent inducer. Aroclor 1260 activated PXR in a simple concentration-dependent manner at concentrations ≥10 μg/mL. Among the congeners tested, PCBs 138, 149, 151, 174, 183, 187 and 196 activated PXR. Aroclor 1260 activated CAR2 and CAR3 variants at lower concentrations and antagonize CAR2 activation by the CAR agonist, CITCO, at higher concentrations (≥20 μg/mL). Additionally, Aroclor 1260 induced CYP2B6 in primary hepatocytes. At subtoxic doses, Aroclor 1260 did not activate LXR or FXR and had no effect on LXR or FXR-dependent induction by the agonists T0901317 or GW4064, respectively. Aroclor 1260 (20 μg/mL) suppressed PPARα activation by the agonist nafenopin, although none of the congeners tested demonstrated significant inhibition. The results suggest that Aroclor 1260 is a human AhR, PXR and CAR3 agonist, a mixed agonist/antagonist for CAR2 and an antagonist for human PPARα.
Article: Sp1 and Sp3 transcription factors regulate the basal expression of human microsomal epoxide hydrolase (EPHX1) through interaction with the E1b far upstream promoter[Show abstract] [Hide abstract]
ABSTRACT: Microsomal epoxide hydrolase (mEH, EPHX1) is a critical biotransformation enzyme, catalyzing the metabolism of many xenobiotics. Human mEH is transcribed using alternative promoters. The proximal E1 promoter is active in liver while the far upstream E1b promoter drives the expression of mEH in all tissues including liver. Although several liver-specific transcription factors have been identified in the regulation of E1 transcription, little is known regarding the mechanisms of E1b transcriptional regulation. Genome-wide mapping of DNase I hypersensitive sites revealed an open chromatin region between nucleotide -300 upstream and +400 downstream of E1b. This area coincides with a previously described promoter region responsible for maintaining high basal promoter activity. In silico analysis of this location revealed several Sp1/Sp3 binding sites. Site-directed mutagenesis of these motifs suppressed the transactivation activity of the E1b proximal promoter, indicating their importance as contributors to E1b promoter regulation. Further, E1b promoter activities were increased significantly following Sp1 and Sp3 overexpression, while Mithramycin A, a selective Sp1 inhibitor, reduced the promoter activities. EMSA studies demonstrated that Sp1 bound to two putative Sp1/Sp3 binding sites. ChIP analysis confirmed that both endogenous Sp1 and Sp3 were bound to the proximal promoter region of E1b. Knockdown of Sp1 expression using siRNA did not alter the endogenous E1b transcriptional level, while knockdown of Sp3 greatly decreased E1b expression in different human cell lines. Taken together, these results support the concept that Sp1 and Sp3 are functionally involved as transcriptional integrators regulating the basal expression of the derived mEH E1b variant transcript.
Article: Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor[Show abstract] [Hide abstract]
ABSTRACT: The constitutive androstane receptor (CAR; NR1I3) is a critical xenobiotic sensor that regulates xenobiotic metabolism, drug clearance, energy and lipid homeostasis, cell proliferation and development. Although constitutively active, in hepatocytes CAR is normally held quiescent through a tethering mechanism in the cytosol, anchored to a protein complex that includes several components, including heat shock protein 90. Release and subsequent nuclear translocation of CAR is triggered through either direct binding to ligand activators such as 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime (CITCO), or through indirect chemical activation, such as with phenobarbital (PB). In this study, we demonstrate that proteasomal inhibition markedly disrupts CAR function, repressing CAR nuclear trafficking, disrupting CAR's interaction with nuclear co-activators and inhibiting induction of CAR target gene responses in human primary hepatocytes following treatment with either PB or CITCO. Paradoxically, these effects occur following accumulation of ubiquitinated hCAR and its interaction with the SUG1 subunit of the 26S proteasome. Together, these data demonstrate that the proteasome complex functions at multiple levels to regulate the functional biology of hCAR activity.
Article: Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator[Show abstract] [Hide abstract]
ABSTRACT: Abstract The constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are important nuclear receptors involved in the regulation of cellular responses from exposure to many xenobiotics and various physiological processes. Phenobarbital (PB) is a non-genotoxic indirect CAR activator, which induces cytochrome P450 (CYP) and other xenobiotic metabolizing enzymes and is known to produce liver foci/tumors in mice and rats. From literature data, a mode of action (MOA) for PB-induced rodent liver tumor formation was developed. A MOA for PXR activators was not established owing to a lack of suitable data. The key events in the PB-induced liver tumor MOA comprise activation of CAR followed by altered gene expression specific to CAR activation, increased cell proliferation, formation of altered hepatic foci and ultimately the development of liver tumors. Associative events in the MOA include altered epigenetic changes, induction of hepatic CYP2B enzymes, liver hypertrophy and decreased apoptosis; with inhibition of gap junctional intercellular communication being an associative event or modulating factor. The MOA was evaluated using the modified Bradford Hill criteria for causality and other possible MOAs were excluded. While PB produces liver tumors in rodents, important species differences were identified including a lack of cell proliferation in cultured human hepatocytes. The MOA for PB-induced rodent liver tumor formation was considered to be qualitatively not plausible for humans. This conclusion is supported by data from a number of epidemiological studies conducted in human populations chronically exposed to PB in which there is no clear evidence for increased liver tumor risk.
Article: The Human Constitutive Androstane Receptor Promotes the Differentiation and Maturation of Hepatic-like Cells.[Show abstract] [Hide abstract]
ABSTRACT: Expression of the constitutive androstane receptor (CAR, NR1I3) is enriched in the mature mammalian liver and increasingly recognized for its prominent role in regulating a myriad of processes including biotransformation, chemical transport, energy metabolism and lipid homeostasis. Previously, we demonstrated that CAR levels were markedly enhanced during the differentiation of hepatic-like cells derived from hESCs, prompting the hypothesis that CAR contributes a key functional role in directing human hepatogenesis. Here we demonstrate that over-expression of CAR in human embryonic stem cells (ESCs), transduced by a lentiviral vector, accelerates the maturation of hepatic-like cells, with CAR over-expressing cells exhibiting a 2.5-fold increase in albumin secretion by day 20 in culture differentiation, and significantly enhanced levels of mRNA expression of several liver-selective markers, including hepatic transcription factors, plasma proteins, biotransformation enzymes, and metabolic enzymes. CAR over-expressing cells also exhibited enhanced CITCO-inducible CYP3A7 enzymatic activity. Knockdown of CAR via siRNA attenuated the differentiation-dependent expression programs. In contrast, expression levels of the pregnane X receptor (PXR), a nuclear receptor most similar to CAR in primary sequence, were negligible in human fetal liver tissues or in the differentiating hESCs, and stable over-expression of PXR in hepatic-induced hESCs failed to enhance expression of hepatic phenotype markers. Together, these results define a novel role for human CAR in hepatic lineage commitment.
Article: Δ 9 -Tetrahydrocannabinol Disrupts Estrogen-Signaling through Up-Regulation of Estrogen Receptor β (ERβ)[Show abstract] [Hide abstract]
ABSTRACT: Δ(9)-Tetrahydrocannabinol (Δ(9)-THC) has been reported as possessing anti-estrogenic activity, although the mechanisms underlying these effects are poorly delineated. In this study, we used the estrogen receptor α (ERα)-positive human breast cancer cell line, MCF-7, as an experimental model and show that Δ(9)-THC exposures markedly suppress 17β-estradiol (E2)- induced MCF-7 cell proliferation. We demonstrate that these effects result from Δ(9)-THC's ability to inhibit E2-liganded ERα activation. Mechanistically, the data obtained from biochemical analyses revealed that: i) Δ(9)-THC up-regulates ERβ, a repressor of ERα, inhibiting the expression of E2/ERα-regulated genes that promote cell growth, and that ii) Δ(9)-THC induction of ERβ modulates E2/ERα signaling in the absence of direct interaction with the E2 ligand binding site. Therefore, the data presented support the concept that Δ(9)-THC's anti-estrogenic activities are mediated by the ERβ disruption of E2/ERα signaling. αααααααααα
Article: Expression of a novel mRNA transcript for human microsomal epoxide hydrolase (EPHX1) is regulated by short open reading frames within its 5'-untranslated region[Show abstract] [Hide abstract]
ABSTRACT: Microsomal epoxide hydrolase (mEH, EPHX1) is a critical xenobiotic-metabolizing enzyme, catalyzing both detoxification and bioactivation reactions that direct the disposition of chemical epoxides, including the carcinogenic metabolites of several polycyclic aromatic hydrocarbons. Recently, we discovered that a previously unrecognized and primate-specific EPHX1 transcript, termed E1-b, was actually the predominant driver of EPHX1 expression in all human tissues. In this study, we identify another human EPHX1 transcript, designated as E1-b'. Unusually, both the E1-b and E1-b' mRNA transcripts are generated from the use of a far upstream gene promoter, localized ∼18.5 kb 5'-upstream of the EPHX1 protein-coding region. Although expressed at comparatively lower levels than E1-b, the novel E1-b' transcript is readily detected in all tissues examined, with highest levels maintained in human ovary. The E1-b' mRNA possesses unusual functional features in its 5'-untranslated region, including a GC-rich leader sequence and two upstream AUGs that encode for short peptides of 26 and 17 amino acids in length, respectively. Results from in vitro transcription/translation assays and direct transfection in mammalian cells of either the E1-b' transcript or the encoded peptides demonstrated that the E1-b' upstream open reading frames (uORFs) are functional, with their presence markedly inhibiting the translation of EPHX1 protein, both in cis and in trans configurations. These unique uORF peptides exhibit no homology to any other known uORF sequences but likely function to mediate post-transcription regulation of EPHX1 and perhaps more broadly as translational regulators in human cells.
Article: Induction of the fatty acid 2-hydroxylase (FA2H) gene by Δ9-tetrahydrocannabinol in human breast cancer cells[Show abstract] [Hide abstract]
ABSTRACT: To investigate gene(s) being regulated by ∆(9)-tetrahydrocannabinol (∆(9)-THC), we performed DNA microarray analysis of human breast cancer MDA-MB-231 cells, which are poorly differentiated breast cancer cells, treated with ∆(9)-THC for 48 hr at an IC50 concentration of approximately 25 µM. Among the highly up-regulated genes (> 10-fold) observed, fatty acid 2-hydroxylase (FA2H) was significantly induced (17.8-fold). Although the physiological role of FA2H has not yet been fully understood, FA2H has been shown to modulate cell differentiation. The results of Oil Red O staining after ∆(9)-THC exposure showed the distribution of lipid droplets (a sign of the differentiated phenotype) in cells. Taken together, the results obtained here indicate that FA2H is a novel ∆(9)-THC-regulated gene, and that ∆(9)-THC induces differentiation signal(s) in poorly differentiated MDA-MB-231 cells.
Article: (−)-Xanthatin up-regulation of the GADD45γ tumor suppressor gene in MDA-MB-231 breast cancer cells: Role of topoisomerase IIα inhibition and reactive oxygen species[Show abstract] [Hide abstract]
ABSTRACT: Previously, we reported that (-)-xanthatin, a naturally occurring xanthanolide present in the Cocklebur plant, exhibits potent anti-proliferative effects on human breast cancer cells, accompanied by an induction of the growth arrest and DNA damage-inducible gene 45γ (GADD45γ), recognized recently as a novel tumor suppressor gene. However, the mechanisms mediating this activation were unknown. Topoisomerase IIα (Topo IIα) inhibition has been reported to produce a cell death response accompanied by an atypical DNA laddering fragmentation profile, similar to that noted previously for (-)-xanthatin. Therefore we hypothesized that (-)-xanthatin's GADD45γ activation was mediated through the Topo IIα pathway. Here, we identify that (-)-xanthatin does function as a catalytic inhibitor of Topo IIα, promoting DNA damage. In addition, reactive oxygen species (ROS) were elevated in cells treated with this agent. Mechanistically, it was determined that the induced levels of GADD45γ mRNA resulting from (-)-xanthatin exposures were stabilized by coordinately produced ROS, and that the consequent induction of GADD45γ mRNA, GADD45γ protein and ROS generation were abrogated by co-treatment with N-acetyl-L-cysteine. Taken together, the data support the concept that Topo IIα inhibition by (-)-xanthatin is a trigger that stimulates expression of DNA damage-inducible GADD45γ mRNA and that concomitantly produced ROS act downstream to further enhance the GADD45γ mRNA/GADD45γ protein induction process, resulting in breast cancer cell death.
Article: Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration[Show abstract] [Hide abstract]
ABSTRACT: Cannabidiol (CBD), a major non-psychotropic constituent of fiber-type cannabis plant, has been reported to possess diverse biological activities, including anti-proliferative effect on cancer cells. Although CBD is obtained from non-enzymatic decarboxylation of its parent molecule, cannabidiolic acid (CBDA), few studies have investigated whether CBDA itself is biologically active. Results of the current investigation revealed that CBDA inhibits migration of the highly invasive MDA-MB-231 human breast cancer cells, apparently through a mechanism involving inhibition of cAMP-dependent protein kinase A, coupled with an activation of the small GTPase, RhoA. It is established that activation of the RhoA signaling pathway leads to inhibition of the mobility of various cancer cells, including MDA-MB-231 cells. The data presented in this report suggest for the first time that as an active component in the cannabis plant, CBDA offers potential therapeutic modality in the abrogation of cancer cell migration, including aggressive breast cancers.
Article: The Orphan Nuclear Receptor DAX-1 Functions as a Potent Corepressor of the Constitutive Androstane Receptor (NR1I3)[Show abstract] [Hide abstract]
ABSTRACT: Regulation of gene transcription is controlled in part by nuclear receptors that function coordinately with coregulator proteins. The human constitutive androstane receptor (CAR; NR1I3) is expressed primarily in liver and regulates the expression of genes involved in xenobiotic metabolism as well as hormone, energy, and lipid homeostasis. In this report, DAX-1, a nuclear receptor family member with corepressor properties, was identified as a potent CAR regulator. Results of transaction and mutational studies demonstrated that both DAX-1's downstream LXXLL and its PCFQVLP motifs were critical contributors to DAX-1's corepression activities, although two other LXXM/LL motifs located nearer the N terminus had no impact on the CAR functional interaction. Deletion of DAX-1's C-terminal transcription silencing domain restored CAR1 transactivation activity in reporter assays to approximately 90% of control, demonstrating its critical function in mediating the CAR repression activities. Furthermore, results obtained from mammalian two-hybrid experiments assessing various domain configurations of the respective receptors showed that full-length DAX-1 inhibited the CAR-SRC1 interaction by approximately 50%, whereas the same interaction was restored to 90% of control when the DAX-1 transcription silencing domain was deleted. Direct interaction between CAR and DAX-1 was demonstrated with both alpha-screen and coimmunoprecipitation experiments, and this interaction was enhanced in the presence of the CAR activator 6-(4-chlorophenyl)imidazo[2,1-b]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime (CITCO). Results obtained in primary human hepatocytes further demonstrated DAX-1 inhibition of CAR-mediated CITCO induction of the CYP2B6 target gene. The results of this investigation identify DAX-1 as a novel and potent CAR corepressor and suggest that DAX-1 functions as a coordinate hepatic regulator of CAR's biological function.
Article: Cannabidiol-2 ',6 '-dimethyl Ether as an Effective Protector of 15-Lipoxygenase-Mediated Low-Density Lipoprotein Oxidation in Vitro[Show abstract] [Hide abstract]
ABSTRACT: 15-Lipoxygenase (15-LOX) is one of the key enzymes responsible for the formation of oxidized low-density lipoprotein (ox-LDL), a major causal factor for atherosclerosis. Both enzymatic (15-LOX) and non-enzymatic (Cu(2+)) mechanisms have been proposed for the production of ox-LDL. We have recently reported that cannabidiol-2',6'-dimethyl ether (CBDD) is a selective and potent inhibitor of 15-LOX-catalyzed linoleic acid oxygenation (Takeda et al., Drug Metab. Dispos., 37, 1733-1737 (2009)). In the LDL, linoleic acid is present as cholesteryl linoleate, the major fatty acid esterified to cholesterol, and is susceptible to oxidative modification by 15-LOX or Cu(2+). In this investigation, we examined the efficacy of CBDD on i) 15-LOX-catalyzed oxygenation of cholesteryl linoleate, and ii) ox-LDL formation catalyzed by 15-LOX versus Cu(2+)-mediated non-enzymatic generation of this important mediator. The results obtained demonstrate that CBDD is a potent and selective inhibitor of ox-LDL formation generated by the 15-LOX pathway. These studies establish CBDD as both an important experimental tool for characterizing 15-LOX-mediated ox-LDL formation, and as a potentially useful therapeutic agent for treatment of atherosclerosis.
- [Show abstract] [Hide abstract]
ABSTRACT: The constitutive androstane receptor (CAR; NR1I3) is a member of the nuclear receptor superfamily and functions as an important xenochemical sensor and transcriptional modulator in mammalian cells. Upon chemical activation, CAR undergoes nuclear translocation and heterodimerization with the retinoid X receptor subsequent to its DNA target interaction. CAR is unusual among nuclear receptors in that it possesses a high level of constitutive activity in cell-based assays, obscuring the detection of ligand activators. However, a human splice variant of CAR, termed CAR3, exhibits negligible constitutive activity. In addition, CAR3 is activated by ligands with similar specificity as the reference form of the receptor. In this study, we hypothesized that similar CAR3 receptors could be constructed across various mammalian species' forms of CAR that would preserve species-specific ligand responses, thus enabling a more sensitive and differential screening assessment of CAR response among animal models. A battery of CAR3 receptors was produced in mouse, rat, and dog and comparatively evaluated with selected ligands together with human CAR1 and CAR3 in mammalian cell reporter assays. The results demonstrate that the 5-amino acid insertion that typifies human CAR3 also imparts ligand-activated receptor function in other species' CAR while maintaining signature responses in each species to select CAR ligands. These variant constructs permit in vitro evaluation of differential chemical effector responses across species and coupled with in vivo assays, the species-selective contributions of CAR in normal physiology and in disease processes such as hepatocarcinogenesis.
Article: (-)-Xanthatin Selectively Induces GADD45 gamma and Stimulates Caspase-Independent Cell Death in Human Breast Cancer MDA-MB-231 Cells[Show abstract] [Hide abstract]
ABSTRACT: exo-Methylene lactone group-containing compounds, such as (--)-xanthatin, are present in a large variety of biologically active natural products, including extracts of Xanthium strumarium (Cocklebur). These substances are reported to possess diverse functional activities, exhibiting anti-inflammatory, antimalarial, and anticancer potential. In this study, we synthesized six structurally related xanthanolides containing exo-methylene lactone moieties, including (--)-xanthatin and (+)-8-epi-xanthatin, and examined the effects of these chemically defined substances on the highly aggressive and farnesyltransferase inhibitor (FTI)-resistant MDA-MB-231 cancer cell line. The results obtained demonstrate that (--)-xanthatin was a highly effective inhibitor of MDA-MB-231 cell growth, inducing caspase-independent cell death, and that these effects were independent of FTase inhibition. Further, our results show that among the GADD45 isoforms, GADD45γ was selectively induced by (--)-xanthatin and that GADD45γ-primed JNK and p38 signaling pathways are, at least in part, involved in mediating the growth inhibition and potential anticancer activities of this agent. Given that GADD45γ is becoming increasingly recognized for its tumor suppressor function, the results presented here suggest the novel possibility that (--)-xanthatin may have therapeutic value as a selective inducer of GADD45γ in human cancer cells, in particular in FTI-resistant aggressive breast cancers.
Article: Selective Phthalate Activation of Naturally Occurring Human Constitutive Androstane Receptor Splice Variants and the Pregnane X Receptor[Show abstract] [Hide abstract]
ABSTRACT: Phthalates and other endocrine-disruptive chemicals are manufactured in large quantities for use as plasticizers and other commercial applications, resulting in ubiquitous human exposure and thus, concern regarding their toxicity. Innate defense against small molecule exposures is controlled in large part by the constitutive androstane receptor (CAR) and the pregnane X receptor (PXR). The human CAR gene undergoes multiple alternative splicing events resulting in the CAR2 and CAR3 variant receptors. Recent studies from our laboratory show that CAR2 is potently and specifically activated by di(2-ethylhexyl) phthalate (DEHP). We hypothesized that alternative splicing is a mechanism for increasing CAR's functional diversity, broadening the human receptors' repertoire of response to environmental xenobiotics. In these studies, we examine the interaction of alternatively spliced CARs and PXR with a range of suspected endocrine disruptors, including phthalates, bisphenol A (BPA), and 4-N-nonylphenol (NP). Transactivation and two-hybrid studies in COS-1 cells revealed differential selectivity of endocrine-disrupting chemicals for the variant CAR and PXR. Ex vivo studies showed DEHP and di-isononyl phthalate potently induced CYP2B6 and CYP3A4 expression in human hepatocytes. Mutation analysis of CAR2, in silico modeling, and ligand docking studies suggested that the SPTV amino acid insertion of CAR2 creates a unique ligand-binding pocket. Alternative gene splicing results in variant CAR receptors that selectively recognize phthalates and BPA. The interaction of phthalates with CAR and PXR suggests a xenobiotic response that is complex and biologically redundant.
- [Show abstract] [Hide abstract]
ABSTRACT: The limited availability of hepatic tissue suitable for the treatment of liver disease and drug discovery research advances the generation of hepatic-like cells from alternative sources as a valuable approach. In this investigation we exploited a unique hepatic differentiation approach to generate hepatocyte-like cells from human embryonic stem cells (hESCs). hESCs were cultured for 10-20 days on collagen substrate in highly defined and serum free hepatocyte media. The resulting cell populations exhibited hepatic cell-like morphology and were characterized with a variety of biological endpoint analyses. Real-time PCR analysis demonstrated that mRNA expression of the 'stemness' marker genes NANOG and alkaline phosphatase in the differentiated cells was significantly reduced, findings that were functionally validated using alkaline phosphatase activity detection measures. Immunofluorescence studies revealed attenuated levels of the 'stemness' markers OCT4, SOX2, SSEA-3, TRA-1-60, and TRA-1-81 in the hepatic-like cell population. The hepatic character of the cells was evaluated additionally by real-time PCR analyses that demonstrated increased mRNA expression of the hepatic transcription factors FOXA1, C/EBPα, and HNF1α, the nuclear receptors CAR, RXRα, PPARα, and HNF4α, the liver-generated plasma proteins α-fetoprotein, transthyretin, transferrin, and albumin, the protease inhibitor α-1-antitrypsin, metabolic enzymes HMGCS2, PEPCK, and biotransformation enzymes CYP3A7, CYP3A4, CYP3A5, and CYP2E1. Indocyanine green uptake albumin secretion and glycogen storage capacity further confirmed acquisition of hepatic function. These studies define an expeditious methodology that facilitates the differentiation of hESCs along a hepatic lineage and provide a framework for their subsequent use in pharmacological and toxicological research applications requiring a renewable supply of human hepatocytes.
Top Journals
William Penn UniversityUniversity Park, Florida, United States
Pennsylvania State University
University Park, Maryland, United States
- Center for Molecular Toxicology and Carcinogenesis
University of PittsburghPittsburgh, Pennsylvania, United States
University of Washington Seattle
Seattle, Washington, United States
- • Department of Medicine
- • Department of Pharmacology
Trinity Washington UniversityWashington, Washington, D.C., United States
University of Vermont
Burlington, Vermont, United States
- Department of Biochemistry
Kent State University
Кент, Ohio, United States
- Department of Chemistry and Biochemistry


text:
Natalia Makarova in On Your Toes.
"This was the night I decided that theater was where I wanted to spend my whole life. Natalia Makarova was incredible. Her entrance was amazing, she was lying in the bed reading the newspaper and all you saw were her legs up in the air. And, she was doing little 'changements dans l'aire' (little switches with her toes) and got 'entrance applause.' Needless to say, the 'Slaughter on Tenth Avenue' dance was overwhelming. She was lying back, Lara Teeter was dragging her along with her fingers touching the floor, and she did those kicks. Eros!"
|Previous 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 Next


text:
- 5 years limited
Shell 10/24/2013
This review is from: SanDisk Cruzer Edge 2GB USB 2.0 Flash Drive 128bit AES Encryption Model SDCZ51-002G-B35
Good performance. I like the password to access to protect and secure files. Compact and retractable plug.
One of the most important features to prevent loss of the unit and your data is where the unit fails and why I can only give it 2 eggs.
The key ring hole on the end of the unit somehow cracked on mine at the end in the middle which allows it to slip off the key ring is any force is applied . I have to take extra measures just to make sure I don't lose the unit. I can no longer carry it on my key ring. I have to keep it in my backpack instead.
Other Thoughts:
I would not recommend this product for anyone who intends to keep it on a key ring or lanyard.
Manufacturer Response:
Hello User,
My name is Allen from SanDisk support. I am sorry to learn that key ring hole of the flash drive has broken. I would suggest you to please contact SanDisk support at 1-866-SANDISK or submit a support request at www.sandisk.com/support for further assistance.
Thank you,
SanDisk support.
Did you find this review helpful? Yes / No Thanks for the valuable feedback you provided!


text:
Singles Sweep Leads Men's Tennis Over Coppin State
Feb. 24, 2014
BALTIMORE - Loyola University Maryland won all six singles matches and lost just one doubles tilt on Monday afternoon, and the Greyhounds beat visiting Coppin State, 7-0, in non-conference action.
The Eagles won the No. 1 doubles match, 8-4, as Oleksiy Krylchuk and Daniel Nino edged the Greyhounds' Harrison Kunkel, but Loyola won the doubles point with wins in the No. 2 and 3 matches.
Greg Olesnycky and Jordan Kuchta teamed to beat Patrick Thomas and Tre'vonne Peyton, 8-5, at No. 2, and Connor Pietrak and Alex Castro defeated Reginald Robinson and Roderick Peyton, 8-1.
Pietrak led off the singles play at the No. 1 spot, holding off Krylchuk in a tiebreaker, 6-1, 7-6 (4). Kunkel then used a super-tiebreaker to edge Nino, 6-1, 5-7 (8), at No. 2.
The remaining four singles players – Lisco (No. 3), Olesnycky (No. 4), Kuchta (No. 5) and Castro (No. 6) – all won in straight sets for the Greyhounds.
Loyola 7, Coppin State 0
1. Connor Pietrak (LOY) d. Oleksiy Krylchuk (CSU), 6-1, 7-6 (4)
2. Harrison Kunkel (LOY) d. Daniel Nino (CSU), 6-1, 5-7, (8)
3. Connor Lisco (LOY) d. Reginald Robinson (CSU), 6-1, 6-0
4. Greg Olesnycky (LOY) d. Roderick Peyton (CSU), 6-0, 6-0
5. Jordan Kuchta (LOY) d. Patrick Thomas (CSU), 6-2, 6-2
6. Alex Castro (LOY) d. Tre'vonne Peyton (CSU), 6-1, 6-1
1. Oleksiy Krylchuk/Daniel Nino (CSU), d. Harrison Kunkel/Connor Lisco (LOY), 8-4
2. Greg Olesnycky/Jordan Kuchta (LOY) d. Patrick Thomas/Tre'vonne Peyton (CSU), 8-5
3. Connor Pietrak/Alex Castro (LOY) d. Reginald Robinson/Roderick Peyton (CSU), 8-1
More Headlines
From Loyola, To Space, To Mission Control, Alum...
Loyola University Maryland men's tennis alumnus Timothy "TJ" Creamer was named ...
Hahn, Lanciano Capture Loyola Invitational Crown
Megan Hahn and Amanda Lanciano teamed to win the inaugural Loyola Women's Tennis...
Hahn, Lanciano To Play For Loyola Invitational ...
Loyola University Maryland's Megan Hahn and Amanda Lanciano will play a team from George...
Two Greyhound Teams Advance At Loyola Women's...
Two Loyola University Maryland women's tennis teams won their opening matches and advanced ...
Play Wraps Up At Loyola Men's Tennis Invitational
Johns Hopkins University men's tennis pairs took the top four spots at the first-annual...
Men's Tennis Wraps Up Day Two Of Loyola...
Connor Pietrak and Alex Castro will play for fifth place on Sunday, the final day of the Loyola...
Castro, Pietrak Advance At First Day Of Loyola ...
The team of Alex Castro and Connor Pietrak advanced to the quarterfinals of the Loyola Men's...
Jones, Shriver Finish Sixth At Villanova...
Loyola University Maryland sophomores Blest Jones and Brett Shriver finished sixth place at this ...
There are no upcoming events.
Team Information• Rosters
Coaching Staff
History & Records
Social Media


text:
Audrey Hepburn 140 colored pen by Ethan-CarlWatch
©2004-2016 Ethan-Carl
Taking a bubble-bath in a cave for the strange film Paris When it Sizzles (1964), Audrey Hepburn sports a unique hair-style and no observable clothing, but lots of suds and lather. Still from movie based, I only like the smile and the hair in this drawing. I hate the hand and arms.
I love her, what a great work!
Your work is really great, it is hard to capture Audrey in a portrait, but you do it frequently, great work!
hahah oh my gosh i love this. I am obsessed with this movie... it's great. You really did a good job on this!
I think the hand and the arms are both great !
The hair is amazing
The hair is amazing
Cuuute! So great scene.. Her face and hairs looks awesome.. Her hand.. well.. 'Nobody is perfect' but Your art almost!
Lol, she looks funny...that hair is VERY...um...unique...special...lol.
awww cute! That's quite an expression.
lolz. brings me back the 'Breakfast at Tiffany's' *sigh*
Awesome picture, I love everything about it!
You captured her face very well.


text:
Born: August 10,1979
Zodiac: Leo
Height: 5 feet 8 inches
Biography: Shabir Sebastian Ahluwalia is an Indian television actor. Some of his noteworthy works include Kahiin to Hoga and Kayamath. He made his debut in Bollywood with the movie Shootout at Lokhandwala and later on went on to act in Mission Istanbul (2008). He has also acted in other serials such as Kyunki Saas Bhi Kabhi Bahu Thi, Kahaani Ghar Ghar Kii, Kasautii Zindagii Kay among others.See full bio
Shabbir Ahluwalia : PhotosSee more photos
Shabbir Ahluwalia : VideosSee more videos
Shabbir Ahluwalia : Filmography
- Kumkum Bhagya 2014


text:
Skip to content, or skip to search.
Skip to content, or skip to search.
125 Seventh Ave. S.,
New York, NY 10014
Mon, 6am-midnight; Tue-Fri, 24 hours; Sat, midnight-10pm; Sun, 8am-10pm
1 at Christopher St.-Sheridan Sq.
American Express, Discover, MasterCard, Visa
Indoor surfing, spinning lovefests, a luxurious pig-placenta facial, and more.


text:
A small book looking at reflections from the viewpoint of light rays and mirrors. The subject matter is public transport in Brno. The pictures were obtained by photographing reflections in a hand held mirror. The photographer managed to avoid being carted off to the local asylum and so has been able to produce this record of a fascinating morning's photography which includes reflections of reflections.
Ian Cowley is an award winning photographer (two 'Highly Commended's , Brentford and Chiswick Foto Klub 1968 and 1974) His work has appeared in a number of publications including the prestigious Sanitary Engineering Gazette. Exiled from Britain by the ban on smoking in pubs, he now lives in the Czech Republic.
Comment posted.
normandy7777 says
Just to apologise that your very kind comment on my book has disappeared when I changed a couple of page details (I had to log it in as a new book. many thanks for your comment. Deeply appreciated.
Keep up the great work.
posted at 05:57PM Aug 21 PST
isee says Many thanks Simon. Glad you liked it. Your beautiful Mourne book is right up my street. Ian
posted at 11:54PM Aug 20 PST
normandy7777 says
Beautifully produced book
I really get this style of photography.
Gets one into deep thinking mode!
An art form for sure
posted at 03:12PM Aug 20 PST
Sign in or create an account to post a comment.
Buses in London Published March 28, 2015
from here to glogow Published September 24, 2014
Untitled Published August 23, 2014
Untitled Published August 23, 2014
Untitled Published August 23, 2014
Untitled Published August 13, 2014
Untitled Published August 13, 2014
Untitled Published June 05, 2014


text:
Monday, December 20, 2010, 11:15 a.m.
By Mark Zuckerman
The Washington Nationals have signed outfielder Rick Ankiel to a one-year, 1.5 million contract, a club source confirmed this morning.
Ankiel, the former Cardinals phenom whose pitching career flamed out nearly a decade ago, has resurrected himself as an outfielder and in 2008 hit 25 homers with 71 RBI for St. Louis. He struggled this season, though, hitting just .232 with six homers and 34 RBI in 74 combined games with the Kansas City Royals and Atlanta Braves.
The 31-year-old, however, is a gifted defensive player with a strong arm and could challenge center fielder Nyjer Morgan or left fielder Roger Bernadina for playing time next spring.
Ankiel's contract, which won't become official until he takes a physical, includes 1.25 million in performance bonuses.
A second-round pick in the 1997 draft, Ankiel sped through the Cardinals' farm system and made his big-league debut two years later at 19. The left-hander went 11-7 with a 3.50 ERA in 30 starts in 2000 and was poised to become a mainstay in St. Louis' rotation for years to come.
But he suffered from a sudden and inexplicable inability to throw the ball anywhere near the plate during the 2000 postseason -- he issued 11 walks and nine wild pitches in only four innings -- and when his control woes continued the following spring, his pitching career came to an abrupt end.
By 2007, Ankiel had made the full conversion to the outfield and battled his way back onto the Cardinals' big-league roster, homering in his first game. Following that season, he admitted using human growth hormone on the advice of doctors; Major League Baseball cleared him of any wrongdoing.
Ankiel was a regular in the St. Louis outfield for two full seasons and posted an .843 OPS in 2008. He became a free agent after the 2009 season and signed with the Royals for 3.25 million, though he played in 27 games for Kansas City due to a quadriceps injury. He was traded along with reliever Kyle Farnsworth to the Braves on July 31 and proceeded to hit .210 with two homers and nine RBI in 47 games.


text:
We promise to never spam you, and just use your email address to identify you as a valid customer.
Posted by Helen on 6th Feb 2015
Soft and silky feeling, a little greasy but it soaks in after a couple minutes. Its not a miracle worker (what is!?) but I am happy with the results. I use it daily and will definitely be buying again


text:
Tags: pretty, black, hottie, huge, round, tits, sucking, cock, deep, banged, behind
Categories: Inter Racial
Submited: 6 years old
Views: 4347
Copyright © 2006 - 2016 DeviantClip.com - All Rights Reserved.
Support / Contact
Webmasters Area
Site Map
All actors and models appearing on this website are 18 years or older.
Section 2257
Pretty black hottie with huge round tits sucking cock deep banged for behind


text:
- Volume Discount
Buy 4+
Save 5%
This product is already in your Wish List.
View Wish List
This product is now in your Wish List.
Eclectic Institute, Uva Ursi, 2 fl oz (60 ml)
By Eclectic Institute2 Reviews
Expiration Date:?Jan 2020
Expiration Date
The length of time for the expiration date or "best used before" date depends on the type of product, as well as the brand.
Perishable items (such as flax oils or certain probiotics) generally have shorter expiration dates. Although our warehouse is fully air-conditioned, these more fragile items are put in cold storage (freezer or refrigeration unit) for maximum freshness.
Our receiving department does its best to verify and then enter the correct expiration dates for all incoming products. However, discrepancies do occur from time to time. This being said, the exceptionally high turnover at iHerb ensures that our inventory is among the freshest in the industry.
Shipping Weight:?0.5 lbs (0.23 kg)
Shipping Weight
The Shipping Weight includes the product, protective packaging material and the actual shipping box. In addition, the Shipping Weight may be adjusted for the Dimensional Weight (e.g. length, width & height) of a package. It is important to note that certain types of products (e.g. glass containers, liquids, fragile, refrigerated or ice packed) will often require protective packaging material. As such, these products will reflect a higher Shipping Weight compared to the unprotected product.
- Product Code: ECL-38815
- UPC Code: 023363388158
- Package Quantity: 2 fl oz (60 ml)
- Dimensions: 1.5 x 1.5 x 4.5 in, 0.3 lbs (0.14 kg)
Total: $37.99
Combo Discount: -$12.00
Together: $25.99
Product Overview
- Grain-Free Alcohol
- Since 1982
- Herbal Extract
- Dietary Supplement
- Arctostaphylos Uva Ursi Leaf
- 500 mg/ml Herb Equivalency
- Non-GMO
- Gluten/Soy/Dairy-Free
- Full Strength
- Vegan
- Organic Alcohol
Suggested Use
Shake well: mix 15-30 drops in water; take 1-3 times daily.
Other Ingredients
Fresh wildcrafted uva ursi (arctostaphylos uva ursi) leaf, organic grain-free alcohol content: 25-35%. filtered water. Fresh herb strength 1:2 (500 mg/ml).
Discontinue if unusual symptoms occur.
Consult your health care advisor regarding the use of herbs during pregnancy, with infants or with prescription drugs.
Store upright. Keep out of reach of children.
iHerb Customer Reviews
Testing revealed 3 types candidas...one responded 100% to uva ursi as compared to using prescription antifungals..
Got it for a younger child on advice of a healthcare practitioner. He couldn't swallow the capsules so we thought we'd try the tincture, however, my youngest child hurled the bottle onto the floor. Thus, we will never know how well it worked.


text:
Kangeroo Animation by marciswierd32Watch
©2005-2016 marciswierd32
Hi everyone this is my first post for a while I have been fairly busy with uni so here is my first of hopefully many animations. Its about a kangeroo who has split personalities. Animation isnt the best quality cuz it was animated within two weeks amoungst other projects. And flash is being an asshole so I cant export it with everything fully in sync but its hardly noticable till final shot. Other than that enjoy and post away.
Hahaha, that was awesome! Great job! I can't say I really liked all the swear words, but they are criminals so I suppose its expected.
It's built way to much like family guy, and family guy isn't funny.
Useless amounts of swareing doesnt make it funny.
Useless amounts of swareing doesnt make it funny.
funniest damn thing i ever saw nice work
Nice. hahaa that was great. the Siren was the best part.
Very nice ! The story was great too
reminds me of golem!
OMG Thats genius lol...
I just love it
I love it!
haha. that was funnnnnyyy.
nice siren. lol. x)
-watches again-
nice siren. lol. x)
-watches again-
ahahahahahaha! that was so funny!
holy crap that was funny
great work
hahahah super funny
funny shit man nice work nice nice work
Nice work.
It's spelt 'Kangaroo' by the way
It's spelt 'Kangaroo' by the way
hahahahahahahhahaaa XDDD omfg, holyport so amazing animation! reminds me fer myself a little definately!
LOL!!!! LMAO!!!! IT WAS SOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO OOOOOOOOOO (and so on) FUNNY!!!! I LUV IT!!!
Oh man, I always knew there was something up with kangeroos. XD Nice work.
my gosh that was,that was...SWEET!!!!!!!!
OK i laughed really hard watching this, really good job, good work. lol what a commedian
this is awesome!
this is awesome!
I think you should've matured this but other than that this kicks big-ass!
Holy crap dude! Frinkin Funny XD Really! I want to see more! Good Job! XD
HahAHahaahaaAha!!! That was so funny, man.
got yourself a +fav from me here for sure
got yourself a +fav from me here for sure
Rofl that was great. Awesome flash work.
that was awesome
again again
again again
Haha, a lot of that was funny as hell.
Hahaha that's awesome. Funniest damn thing I've seen in ages. + 1 fav dude.
Mega awesom ^^
aw.. looks so lonely..
That was fucking awesome!
lol that is hilarious, i hope he does hurt mr bunny again lol
Hahaha very nicely done! That bear touching his toes was my fave part tho Keep up the ace work!
you crazed lunatic. you're brilliant.


text:
(based on 30 reviews)
of respondents would recommend this to a friend.
Ratings Distribution
5 Stars
4 Stars
3 Stars
2 Stars
1 Stars
Best Uses
Feels too small
Feels true to size
85% (22 reviews)
(22 reviews)
Feels too big
Feels too short
Feels true to length
96% (25 reviews)
(25 reviews)
Feels too long
Reviewed by 30 customers
Sort by
Displaying reviews 1-10
Back to top
Previous | Next »
Ride everyday, 83 years old, 20 to 30 miles a day.
By Pop
from Ny
About Me Avid Cyclist
Comments about Primal Wear U.S. Army Camo Jersey:
Fits to size, looks great , nice to honor the ones fighting for our freedom while we're enjoying a nice ride.
Bottom Line Yes, I would recommend this to a friend
Was this review helpful? Yes / No
- You may also flag this review
Comment on this review
Awesome Awesome. All positives
By pete3306
from Texas
See all my reviews
Looks and wears Great!
By Ike
from Clermont, Florida
About Me Casual/ Recreational
I have worn this a couple dozen times and proud to wear it and it still looks like new. Feels great too!
Army Strong
By Jim
from Central Ohio
Great item for great price
Great Jersey
By Pappy
from Indiana
Good size for me at XXL. 6'2" and 235. When I get to 200 maybe I'll buy the XL size. As weather cools I will wear this over a long sleeve jersey.4 stars cuz the zipper may be too fragile- take care when zipping, etc.
Good Fit..
It fits very well and looks good as I am a Vet, it cools really well compared to my t-shirt I used to wear riding. Very happy with it..
Just what I wanted
By Rich
from Oceanside, CA
I always wanted an Army jersey but they were always black or brown which attracts too much heat. The digital camy is just right.
Great fit, show my pride
By rjcutiger
from Winchester, VA
I really wanted to show my love for the Army as a Veteran. Ride to work in it. I'm new to cycling and this is my first shirt, but it seems like the zipper is a hard to find. I know I can't do it while riding, yet!
Great jersey
By Junior
from Fajardo, Puerto Rico
It is worth the money, yes I would recommend it.
Good quality
By Randy
from Tequesta Fl.
Like this jersey but did not realize it is only a 3/4 length zipper.
Item No. »
We Make Shopping Safe, Secure and Easy
© 2016 Nashbar. All Rights Reserved.
Return to Mobile


text: Posted 11 Nov 2011 Why am i not allowed to upload more than 10 files at once when adding a topic? In the gallery, this limit has been lifted with the upgrade to the latest version... what's the point to still have it in the forum? referring 'issue' in the tracker:http://community.invisionpower.com/tracker/issue-34372-10-files-upload-limit-in-forum-and-no-limit-in-gallery/ Marcher Technologies likes this Share this post Link to post Share on other sites


text:
Acts 17:27King James Version (KJV)
27 That they should seek the Lord, if haply they might feel after him, and find him, though he be not far from every one of us:
King James Version (KJV)
Already have a redemption code? Redeem it here.
Already redeemed? Refresh the page.
This is a content preview. Buy this title to see more.


text:
I just love pulling together festive tablescapes for holidays, don't you?! I shared my Ikat & Carrots Easter table last week, and today I have a sweet blue, white and yellow table to share with you. My love for chinoiserie and all things blue and white are certainly not a secret, so I love any opportunity to pull out my blue and white china.
I layered my china atop a textured white tablecloth, and used cobalt blue wine glasses. My large white urn held center stage as a centerpiece, and I added a pop of color with footed bowls of chocolate foil eggs from See's Candies. My little guests couldn't wait to dive into the bowls of candy!
My favorite part of the tablescape are the napkins/placecards. I rolled up crisp, yellow napkins and tied them together with a bow. I placed a hard-boiled egg into the center of the bottom portion, and then wrote my guests' names on them with a navy blue marker. I love how they look like bunny ears, yet still sophisticated enough for the overall look of the table.
Every party needs a party favor! I sent my guests home with a large chocolate Easter egg from See's Candies, wrapped in cellophane and a sweet gift tag!


text:
so i want to buy a pair of diesel shoes, but i dont plan on going to a city anytime soon. i plan on ordering a pair on line. i have no idea what size i wear in diesel shoes. just wondering if anyone could help me out with compairing other sizes from different shoes companies. i wear a 11.5 in chucks, 11.5 in kennith cole, 12 in aldo, an 11 in diadora, and a 11.5 in banana republic, thats all i can think of off the top of my head.
post #1 of 7
3/4/05 at 12:49pm
Thread Starter


text:
Clip From
November 13, 2012 U.S. Debt and the Global Economy
". . . We're Deeply Divided Between People Who Are Collecting And Between People Who Are Paying. . ."
Michael Boskin, Professor, Stanford University, and the Hoover Institution, Fellow
Video Library clips and descriptions are created by MyC-SPAN users, and are not the editorial selections of C-SPAN.Report profane or abusive content
People in this video
- Austan Goolsbee Chair (Former) White House->Council of Economic Advisers
Hosting Organization
More Videos From
Wall Street Journal CEO Council
- Senator Kent Conrad on the Fiscal Cliff
- Representative Christopher Van Hollen on the Fiscal Cliff
- Treasury Secretary Geithner Remarks
- Former Secretary of State Henry Kissinger on Foreign Policy
- Online Consumer Privacy
- European Debt Crisis
Clips from This Video
Related Video
Economic Outlook
Stanley Fischer talked about the global economic outlook. Topics included oil supply and prices and short-term…
Representative Christopher Van Hollen on the Fiscal Cliff
U.S. Representative Christopher Van Hollen, Jr., (D-MD), the ranking member of the House Committee on the Budget,…
Senator Kent Conrad on the Fiscal Cliff
Senator Kent Conrad (D-ND), chair of the Senate Budget Committee, talked about the "fiscal cliff," the…
Treasury Secretary Geithner Remarks
Treasury Secretary Tim Geithner defended President Obama's insistence on vetoing any bill that extends Bush-era…


text:
Does anywhere sell these sort of socks?(13 Posts)
IJustWoreMyTrenchcoat Thu 18-Jul-13 21:30:39
AnythingNotEverything Thu 18-Jul-13 11:26:43
Dontletthemgetyoudown Thu 18-Jul-13 11:13:26
TapselteerieO Thu 18-Jul-13 11:12:12
Dontletthemgetyoudown Thu 18-Jul-13 11:10:25
Aquelven Thu 18-Jul-13 07:28:59
Springcleanish Thu 18-Jul-13 06:58:59
MrsPnut Thu 18-Jul-13 06:54:27
Aquelven Thu 18-Jul-13 06:49:22
MrsMangoBiscuit Thu 18-Jul-13 06:27:00
TWinklyLittleStar Thu 18-Jul-13 06:26:57
Hobbes8 Thu 18-Jul-13 06:24:06
Aquelven Thu 18-Jul-13 06:20:34
Join the discussion
Registering is free, easy, and means you can join in the discussion, get discounts, win prizes and lots more.Register now
Already registered with Mumsnet? Log in to leave your comment or alternatively, sign in with Facebook or Google.
Talk: Customise | Unanswered messages | Getting started | Acronyms | FAQs
Threads: Active | I'm on | I'm watching | I started | Last 15 minutes | Last hour | Last Day
Please login first.


text:
More Products By Jim Dratfield:
Average rating from 2 reviews.
Average rating from 1 reviews.
Similar Products:
Average rating from 30 reviews.
Average rating from 21 reviews.
Average rating from 17 reviews.
Editor's Best Lists:
Products We Are Testing:
Underdogs: Beauty Is More Than Fur Deep
Average rating from 2 reviews.
(4.5 out of 5, based on 2 reviews)
Photosadd photo
Reader's Reviews (2)
Who doesn't love an underdog?
posted 7 years ago
So who doesn't love an underdog? Volunteer at a shelter, we often band together for those dogs that just otherwise don't get a chance or aren't perfect. Dratfield has captured very cute images of these dogs in his book. It's a tiny book, not as large as some of his others. But it's packed with cute pictures (again white, brown, and black tones), and inspiring quotes on each page. Great coffee table book.
Pros: Lots of mutts and not so popular breeds
Cons: None
0 of 0 people found this review helpful.
Did you?
Nice black and white dog photos
posted 7 years ago
A short book of dog photographs--a handful of purebreds, but mostly mutts. The photographer indicates in his introduction that he didn't want to take pictures of the 'glamour' breeds so often featured. Most of his dogs photos are of mutts and they are adorable. All photos are in black and white and each photograph has an accompanying quote from some famous person (which seems to be all the rage in dog/cat gift books lately). I would have loved to see more information on the dogs--what breeds they think they might be, etc.
Pros: Fun photographs
Cons: Would prefer 'biographical' information on the dogs to the quotes
0 of 0 people found this review helpful.
Did you?
Want to review a product, but not finding it? Just add it and review it!
Recent Product Reviews
Tapeworm Tablets
June 8, 2015 | By Lynn
I've used this product on rescued dogs for years. My last large dog rescued had been an outdoor dog her entire life, living among Lamas where she picked up tapeworms. This product expelled several 2 … more ›
November 15, 2014 | By Robyn
July 14, 2013 | By Xiaoxiao111
Pink is my favorite color these are wonderful.I will recommend a good website fou you: www.9footballshirt.org


text:
AdBlock blows! Please disable the add-on to ensure you get the most out of Tube8's features and functionality. Read about why you shouldn't use AdBlock. Close
Add to Favorite List:
Create a new folder:
Next »
He gives her an anal ride which she had never experienced
Recognize a pornstar in this video?
Help make pornstars easier to find on Tube8 by telling us who is in this video.
Thanks! The pornstar names will be added to this video when enough users submit the same names.
You must enter a pornstar name that already exists in our database.
- Description: Horny guy came to this sweet student to help her with the English lessons but this teen cutie has a very sexy butt while her tutor is a fan of anal sex. Despite her short opposition he finds the way to penetrate into her round booty after pounding her wet
- Tags: teen, young, skinny, shaved, homemade, amateur, russian
- Pornstars: Add Pornstar
- Favorite by: 545
- Featured: 4 years ago
- Report This Video
Video Comments
All Video Comments (4)
4 years ago
4 years ago
j'adore regarder ces petites filles à papa se fairent enculer, la petite culotte juste baissée sur les cuisses
- 0 people liked this -


text:
Join spankwire.com today for FREE, and gain added functionality
that members enjoy.
Passwords are case sensitive.
amateur facial
If I had a piece of that in front of me, I would do a lot more than just jack off in front of her.
that is a really hot facial
Boring BS
Help improve Spankwire by telling us who
the stars are in this video.
Pornstars are added once we get
enough submissions with the same name.
Privacy Policy | Terms of Use | 18 U.S.C. 2257 |
Contact | DMCA
| Feedback | Mobile version | Sitemap


text:
Searched for: "regaining control of the desktop"
About 15 results for "regaining control of the desktop"
Pro tip: Take back control of resolv.conf
If you're tired of your Linux system's resolv.conf file being overwritten, Jack Wallen has the solution for you.
Cisco and VMware: Virtualizing the Desktop
The traditional approach to managing desktops in a global enterprise has become untenable. Increasingly, geographically dispersed user endpoints, in the form of desktop and laptop ...
Roundup: What's next for Microsoft? Tech executives speak out
Opinions vary on the next step for Microsoft after CEO Steve Ballmer steps down. TechRepublic's roundtable of IT executives gives insight on the public mindset about the upcoming changes.
How to recover email from Apple Mail corruption
Regaining access to lost or corrupted Apple Mail is a common task for admins. From simple rebuilds to complex recovery operations, here are five levels of fixes you may be called on to make.
Ten questions on BYOD in the enterprise, with Peter Price, CEO of Webalo
Jeff Cerny talks with Peter Price, the co-founder and CEO of Webalo about the effect of BYOD on the enterprise.
Tech Dossier: A faster path to client virtualization
An increasingly popular way to regain control of the desktop is client virtualization. Client virtualization encapsulates a user's desktop--including operating system, applications...
Nine tips to help unleash the power of the Droid X
Jack Wallen offers some tips for the Droid X that will help you unleash the power of the device.
Does Office 365 signal the end of Small Business Server?
Office 365 is being touted as the perfect solution for the same small businesses currently using Microsoft's Small Business Server to get Exchange and SharePoint. Will the cloud kill SBS?
Surveying the mobile development landscape
Keeping up with the rapidly changing mobile development industry can be a challenge. This developer's overview of the mobile market will get you up to speed.
Will Firefox 3.0 rekindle the browser wars?
Firefox 3.0 has finally launched. Will it relaunch the browser wars of the 90's? Take our poll and see what other TechRepublic members think.


text:
The plunging v neckline of this gown, by Faviana 6918, features straps that are beautifully embellished to compliment the dynamic print. The soft printed fabric is vibrant and fun as it hugs curves falling in a column shape to the floor.
Find a lower price and we will match and beat it by 5%
We are an authorized retailer of all the dresses we sell. We only sell 100% authentic dresses.
Please refer to our return policy.
Free ground shipping on orders over $50.
Read More


text:
This book is a completely original collaboration between two artists, the writer W.G.Sebald and the painter Tess Jaray. Tess Jaray first met W.G.Sebald in December 1999, having been profoundly moved by his two books, "The Emigrants" and "The Rings of Saturn". The idea of their working together seemed to follow naturally. "For Years Now" contains 23 short stories by W.G.Sebald - the first that he has written in English - each of them paired with a related image by Tess Jaray.
"synopsis" may belong to another edition of this title.
Within U.S.A.
Book Description Short Books, 2005. Book Condition: New. Brand New, Unread Copy in Perfect Condition. A+ Customer Service!. Bookseller Inventory # ABE_book_new_1904095097
More Information About This Seller | Ask Bookseller a Question
Book Description Short Books, 2001. Paperback. Book Condition: New. Bookseller Inventory # P111904095097
More Information About This Seller | Ask Bookseller a Question


text:
a beautiful rustic wedding venue
- Loading...
Fancy for Chrome. Add items to your collection from across the web.Add to Chrome
Check out Fancy for Firefox - add items to your collection and keep up with friends.Add to Firefox
a beautiful rustic wedding venue
Keyboard Shortcuts
This thing was successfully sent.
Enter your email address to reset your password.
We've sent you an email. Click the link in the email to reset your Fancy password.
Choose your currency
Edit thing
Fancy'd by
Fancy'd by friends


text: Ok so I need to get a 3foot stump out of concrete without damaging the concrete. It's at that terrible stage where it's to rotten to pull out and to solid to scoop out. My idea is to drill a hole and pour liquid nitrogen down the hole to make the wood brittle and then smash it with a pry bar. Will it make the wood brittle or will it make the wood stronger like it does with a banana?


text:
- The Experience
- The Programs
- MBA Program
- MSx Program
- PhD Program
- Executive Education
- Stanford Ignite
- Research Fellows Program
- Summer Institute for General Management
- Stanford LEAD Certificate: Corporate Innovation
- Stanford Innovation & Entrepreneurship Certificate
- Executive Program for Nonprofit Leaders
- Executive Program in Social Entrepreneurship
- Executive Program for Education Leaders
- Stanford go.to.market
- Faculty & Research
- Insights
- Alumni
- Events
Feb 19
12:10pm - 1:10pm
Stanford, CA
Join us for the View From The Top event with Major General Charles Frank Bolden, Jr. (USMC-Ret.), head administrator of NASA.
Monday, February 1, 2016
Learn about key scaling concepts in this free, five-week online course taught by Stanford professors Huggy Rao & Bob Sutton.
Thursday, February 11, 2016
Half-Quarter Instruction Begins (Feb 11-12)
Monday, February 15, 2016
President's Day | No Classes
Wednesday, February 17, 2016
Stanford GSB Monday Classes Meet
4:30pm – 5:30pm
Join us for a conversation with James Freeman, CEO of Blue Bottle Coffee.
Friday, February 19, 2016
12:10pm – 1:10pm
Join us for the View From The Top event with Major General Charles Frank Bolden, Jr. (USMC-Ret.), head administrator of NASA.
Monday, February 22, 2016
12:10pm – 1:10pm
Join us for a Global Speaker Series event with Sir Ronald Cohen, co-founder of Apax Partners, Big Society Capital, and many other companies.
Wednesday, February 24, 2016
8:30am – 3:00pm
Our theme this year: Digital Innovations and Disruptions in Media.
10:00am – 11:00am
GSB Lecturer J.D. Schramm's complimentary webinar sharing case studies of successful leaders—from within and outside of the LGBT community.
4:30pm – 5:30pm
Join us for a conversation with Federica Marchionni, CEO of Lands' End.
Saturday, February 27, 2016
5:00pm – 6:00pm
All GSB alumni who will be on campus during Stanford Parents' Weekend are invited to come to the GSB for a casual reception.
Monday, February 29, 2016
6:30pm – 9:00pm
Join us for a lively and inspiring All Circle Meet-Up for Stanford GSB Women's Circles – San Francisco.
Wednesday, March 2, 2016
8:00am – 4:00pm
Join us as we bring together thought leaders, alumni, and current MBA students to have a conversation about the future of sports.
Join us for a conversation with Suzanne DiBianca, president of Salesforce.
Thursday, March 3, 2016
6:30pm – 10:00pm
At this annual event, the Stanford GSB Alumni Association recognizes an individual who demonstrates excellence in management leadership.
Saturday, March 5, 2016
6:00pm – 11:00pm
The Hispanic Business Student Association (HBSA) invites you to its annual award banquet.
Thursday, March 10, 2016
10:00am – 11:00am
Professor Callander will examine how being proactive, thinking holistically, and communicating strategically can help you handle the unexpected.
Friday, March 11, 2016
Last Day of Classes
Monday, March 14, 2016
Final Exams (Mar 14-18)
Wednesday, March 16, 2016
7:00pm – 10:30pm
The Stanford Graduate School of Business Alumni Association and the Tokyo Chapter invites you to attend a conversation with Dean Garth Saloner.
Monday, March 21, 2016
Spring Recess (Mar 21-25) | No Classes
Monday, March 28, 2016
First Day of University Classes
Thursday, March 31, 2016
First Day of Stanford GSB Classes
Monday, April 11, 2016
12:10pm – 1:10pm
Join us for the View From The Top event with Arianna Huffington, cofounder and editor-in-chief of The Huffington Post.
Wednesday, April 27, 2016
Thursday, April 28, 2016
Half-Quarter Instruction Ends (Apr 28-29)
Monday, May 2, 2016
Half-Quarter Instruction Begins (May 2-3)
Wednesday, May 4, 2016
Exams (May 4-11)
Thursday, May 5, 2016
12:10pm – 1:10pm
Join us for the View From The Top event with Philippe Dauman, president and CEO of Viacom Inc.
Tuesday, May 10, 2016
12:10pm – 1:10pm
Join us for the View From The Top event with Indra Nooyi, CEO of Pepsi Co., in conversation with Doug McMillon, CEO of Walmart.
Monday, May 30, 2016
Memorial Day | No Classes
Wednesday, June 1, 2016
Last Day of Classes
Stanford GSB Monday Classes Meet
Friday, June 3, 2016
Final Exams (Jun 3-8)
Saturday, June 11, 2016
Join us as we celebrate the achievements of our graduating students and send them off to launch careers of meaning and impact.


text:
COMMENT: UK still a nation of beer lovers
The wider availability of new technology, such as home entertainment systems and broadband Internet connections, is encouraging consumers to stay at home rather than go out to pubs or bars.
Get full access to all content, just $1 for 30 days
A Message From The Editor
just-drinks gives you the widest beverage market coverage.
Paid just-drinks members have unlimited access to all our exclusive content - including 16 years of archives.
I am so confident you will love complete access to our content that today I can offer you 30 days access for $1.
It's our best ever membership offer – just for you.
Olly Wehring, editor of just-drinks
Olly's offer to you
Risk-free, money-back guarantee
Most Popular
- Aus wine industry pays price for past failures
- Six key trends for alcoholic drinks in 2016
- What's in store for Super Bowl 50 - Focus
- Ten things to know about spirits in the US
- Will value-sharing in Travel Retail become reality
- William Grant & Sons restructures US team
- Diageo's Orphan Barrel The Gifted Horse - NPD
- Diageo completes wine category exit in US
- Diageo's Oban Little Bay single malt Scotch - NPD
- Beam Suntory targets Kenya with Edrington/FIX
Market research
- What Next for Beer and Brewers Following the MegaBrew Deal?
- Global travel retail insights - market forecasts, product innovation and consumer trends
- Global Beer Trends 2015 : Global Beer Trends and Long-term Forecasts
- Global Whiskey Market 2016-2020
- Global sparkling wine insights - market forecasts, product innovation and consumer trends research


text:
The University of Louisville Honors Student Council (HSC) exists to create a variety of academic, social, and volunteer events to enhance and engage the Honors community and interact with each other. The Council also functions as a channel of communication through which Honors students can express their thoughts about the Honors Program and contribute their ideas for its improvement.
HSC invites students in or interested in the Honors Program to attend our events during the fall and spring academic semesters. We invite you to check out our events that are coming up soon and our calendar for the entire year.
For more information about Honors Student Council, please visit our OrgSync account or find us on Facebook.


text:
We keep seeing "the password for the AirPlay device Apple TV is incorrect. How do we retrieve or change the password?
Welcome to the Apple community.
You need to reset the password from your Apple TV, go into settings > AirPlay and turn the password off and then on again and set a new one.
Retrieving data ...


text:
From the PlanetPSX feature review:
"A lot of people have been on the fence about EA's offered Battlefield 3: Premium package, dismissing it as that company's version of the "Call of Duty Elite" package, but without the exhaustive online options for clans and so forth. But I think DICE had a different approach to Premium, looking to expand the action itself rather than the technical data behind it. They're not concerned with how someone jumps into the action, just as long as they do it. Their first DLC for Battlefield, Back To Karkand, wasn't half bad, though there really wasn't enough in this pack to separate what you were doing in the main game. It was good, though, especially for fans." -


text:
We spent the night at this Holiday Inn after a meeting. We were greeted by nice friendly staff and were checked in fast. They are very family friendly with a wonderful pool area for everyone from young kids to adults. Our room was very nice with a refrigerator and microwave. Parking was good and free. It is close to the airport but very quit.
- Official Description (provided by the hotel):
- Welcome to the Holiday Inn Express Hotel & Suites Milwaukee Airport. The Holiday Inn Express Hotel & Suites Milwaukee Airport is a 100% smoke free hotel. We are centrally located to everything in Milwaukee. Whether your visiting Milwaukee for business or pleasure, the Holiday Inn Express Hotel & Suites Milwaukee Airport is the best fit for your plans. We are conveniently located less than 2 miles from the General Mitchell International Airport with 24-hour complimentary shuttle service to and from the airport. If your visiting one of Milwaukee's largest businesses you are also just a stone throw away. Krones is less than 5 miles away, Rockwell Automation is only 6 miles, Miller Brewery is only 7 miles, Harley Davidson is only 7 miles, Cooper Power is only 6 miles, We-Energies is only 5 miles, Cessna Citation is only 2 miles, Patrick Cudahy is only 4 miles, and General Mills is only 3 miles away. TheHoliday Inn Express Hotel & Suites Milwaukee Airport caters to the needs of business travelers with such unique programs as: 3,000 Bonus Priority Club Points for stays of two days or more, see rates for details. Stay connected while away from the office with free high-speed wireless Internet with easy to use VPN access. Pool, gameroom & whirlpool hours are: Sunday 9 AM - 9 PM, Monday - Thursday 9 AM - 3 PM, Friday & Saturday 8 AM - 10 PM. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Expedia, Booking.com, IHG, Priceline, Orbitz, Hotels.com, Travelocity and Odigeo so you can book your Holiday Inn Express Hotel & Suites Milwaukee Airport reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Holiday Inn Express Hotel And Suites Milwaukee Airport
- Holiday Inn Express Milwaukee
- Holiday Inn Milwaukee


text:
Yamal Peninsula - an infinite snowy desert, a border area, the largest gas extraction region ... and the North of incredible beauty.
Those who come here usually call it expedition. There is no denying the truth, roads do not tend here. In winter there are ice roads, they are made right along the stream canals, the Ob feeders, taiga. Dozens of ice passages, villages, and in summer only water ways may take there. Recesses...
But let us come back to Yamal Peninsula itself.
The ice road tends here from the side of Labytnanga, Obskaya station.


text:
Featured news
Yet another worldwide virus scare that wasn't
Yet another mobile virus is making the news, but the press still hasn't recognized that most of these stories are hyped up well beyond the actual threat level.
Seeing one more mobile virus scare is nothing new. They come in all sorts of shapes, sizes and colors these days -- often with little to back up the fear mongering other than some quotes from anti-virus software firms and maybe a healthy misunderstanding of the technology at hand.
By Mike Masnick at The Feature.
[ Read more ]
Reading our newsletter every Monday will keep you up-to-date with security news.
Receive a daily digest of the latest security news.


text:
What does DWMMC stand for?
What does DWMMC mean? This page is about the various possible meanings of the acronym, abbreviation, shorthand or slang term: DWMMC.
We've found a total of 1 definition for DWMMC:
Filter by: Sort by:PopularityAlphabeticallyCategory
Deployed Warrior Medical Management Center
Still can't find the acronym definition you were looking for? Use our Power Search technology to look for more unique definitions from across the web!
"DWMMC." Abbreviations.com. STANDS4 LLC, 2016. Web. 8 Feb. 2016. <http://www.abbreviations.com/DWMMC>.


text:
Asian Formula Renault (AFR) is a one-make race held in China and Malaysia which main machine will be using the Formula cars
made by Renault in France. It has been holding for 15 years since the first season started in 2000. Many new comers had been
successfully fight through all the challenges and won the trophy of the Asian Formula Renault. Is been a long history when Asian
Formula Renault started helping novice drivers developing or already become a professional, coach, or even a Formula One driver.
In the past 2014 there was a critical successful from a female driver – Alice Powell, who joined AFR for the first year and made
it to the champion all the way that she also became the first ever woman to win this series. Teams from other countries are
joining this war and trying to get the trophy back to home.
Redesigned for the 2014 AFR season, Formula Renault 2.0 puts the emphasis on aerodynamic efficiency and features a chassis
that is even more responsive to tuning. Also boasting a 210bhp engine and a sequential gearbox with steering wheel-mounted
controls, it offers very high performance. Something of a single-seater academy, Formula Renault 2.0 gives drivers every
opportunity to demonstrate their talents.
AFR will continue to cooperate with Zhuhai International Circuit (ZIC) and organize 4 weekends of races in ZIC. In addition, the
series will visit F1 tracks at Shanghai and Malaysia for races. With FRD's sophisticated & effective promotional approach and massive
support from the teams, drivers and partners, AFR will try to bring another brilliant season and lay down a solid foundation for more
new development in 2015.