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"Arise and take our stand for freedom as in the olden time." Winston Churchill
"Proclaim Liberty throughout All the land unto All the Inhabitants Thereof." Inscription on the Liberty Bell
George W. Bush
Gilson's gallimaufry
In today's letters to the editor the Star Tribune publishes Gary Gilson's apology for his sideswipe of John Hinderaker while swiping me head-on. Here is how it is published it today's paper: DEBATE OVER THE MOVIE 'TRUTH' I apologize for a statement made about the Power Line blog In a Nov. 8 letter to the editor, I wrote that John Hinderaker, a founder of the conservative blog Power Line, had »
Discipline in the 2016 race
John Sears, Ronald Reagan's one-time campaign manager, once said "discipline is nine-tenths of politics." And, as Tevi Troy reminds us: Candidate Reagan put Sears' dictum into action, running a relentlessly focused communication operation that kept to its message of the day, often to the consternation of the reporters following the campaign. This approach continued into Reagan's presidency. As the authors of All the President's Spin put it: "Ronald Reagan's administration »
"Truth" hurts [corrected]
The Rathergate film Truth opened in wide release this past Friday. I took a look at the weekend box-office estimates posted by Box Office Mojo in "Truth doesn't pay." The film did not appear to be doing well even by comparison with Scouts Guide to the Zombie Apocalypse. Hollywood Reporter observes that the film flopped on its opening this past weekend. Nevertheless, we may have underestimated the magnitude of the »
Lies of "Truth"
The Rathergate film Truth opened in more than a thousand theaters around the country this past Friday. The Sunday Star Tribune carries my column reminding readers of the film's factual background. The column is published as "Lies upon lies: The sad state of the movie 'Truth.'" I am grateful to Star Tribune commentary editor D.J. Tice for letting the column see the light of day in the hometown paper. Please »
"Truth" and other lies (5)
Dorothy Rabinowitz is a member of the Wall Street Journal editorial board who also contributes excellent reviews of television programs and series to the Journal's coverage of the arts. This past Friday, I wondered what was up when Journal film reviewer Joe Morganstern omitted any mention of the Rathergate film Truth, which had just opened in New York. Perhaps Morganstern had given way to Ms. Rabinsowitz, for now comes Ms. »
Donald Trump's most offensive Democratic talking point yet
Donald Trump is fond of using Democratic talking points. This isn't surprising. Not that long ago, he admitted to being more of a Democrat than a Republican on the issues. Among other Democratic talking points, Trump has erroneously blamed Republicans for the recession of 2008 and criticized Scott Walker for not raising taxes while parroting Democratic claims that Wisconsin has a $2.2 billion deficit. And I'm not even counting Trump's »
"Truth" and other lies (4)
In his article on the New York Times love-in with the perpetrators of Rathergate and the stars of the Rathergate film Truth, Times reporter John Koblin quotes director/writer James Vanderbilt: Mr. Vanderbilt said that he did not want to impose a specific point of view in the movie but instead wanted to simply raise questions. "As a filmmaker I'm not interested in re-prosecuting something, so much as this was a »
"Truth," according to the Times (5)
John Koblin reports in the New York Times on the Times's own love-in last week featuring Robert Redford, Cate Blanchett, Dan Rather, and Mary Mapes discussing the Rathergate film Truth. Rich Lowry likened the festivities to "a dispatch from another planet." Koblin's report captures none of the weirdness. It's just another day's work. Perhaps most notably, Koblin observes strict limits reflecting his apparent lack of knowledge regarding Rathergate itself. To »
"Truth," according to the Times (4)
The Rathergate film Truth opens today in New York and Los Angeles. It's coming soon to a theater near you. It opens across the country on October 30. As we might have anticipated, New York Times critic Stephen Holden gives the film a rave review in "'Truth' treads a perilous political tightrope." The rather glaring fraud at the center of the events becomes "a suspenseful detective story in which the »
"Truth," according to Mary Mapes
The Rathergate film Truth opens in New York and Los Angeles on Friday. The film, as I've mentioned a time or two before, is based on Mary Mapes's Rathergate memoir Truth and Duty. Mapes stands behind the false and fraudulent story that disgraced CBS News. She stands behind the fabricated documents on which the story was based. And now she has Cate Blanchett taking a star turn on her behalf »
"Truth," according to the Times (3)
I have taken another pass at commenting on this past Thursday's New York Times love-in with Robert Redford, Cate Blanchett, Dan Rather, and Mary Mapes talking about the forthcoming Rathergate film Truth. I take a whack at the Times in the City Journal column "Truth and the New York Times." Power Line readers don't need my brief refresher course on the facts of the scandal, but I think you will »
"Truth," according to the Times (2)
Late last week the New York Times celebrated the forthcoming release of the Rathergate film Truth, starring Robert Redford as Dan Rather and Cate Blanchett as Mary Mapes. The Times event featured all four of them. "The full catastrophe," as I would like to think of it. The Times convened the panel to discuss the film and the underlying story before an enthusiastic New York audience. Moderated by Times Magazine »
"Truth," according to the Times [updated]
This past Thursday the New York Times hosted a TimesTalks conversation moderated by New York Times Magazine staff writer Susan Dominus and featuring Robert Redford, Cate Blanchett, Dan Rather, and Mary Mapes. "The full catastrophe," as Zorba puts it. They discuss the film Truth, which opens commercially in New York this coming Friday, before a large and enthusiastic audience. I have posted the video below (about 90 minutes long); the »
Donald Trump's phony claim of prescience about the Iraq war
Donald Trump rarely misses an opportunity to tout his early opposition to the war in Iraq. But how early did his opposition come? If it predated the invasion (and Trump had ample opportunity publicly to oppose intervention during the long build-up to the war), then he can claim to have been prescient, assuming that the war was a mistake. If not, then Trump was just one of many voices who »
Harry MacDougald: "Truth" and other lies (2)
The film "Truth" will be released commercially later this month to retell the Rathergate scandal from the perspective of Mary Mapes. The film is based on Mapes's almost laughable 2005 Rathergate memoir. The left routinely seeks to rewrite even yesterday's news; events eleven years ago, when Mapes committed her misconduct, have now attained the status of ancient history. John and I therefore sought to reiterate the basic facts of the »
"Truth" and other lies
The film Truth premiered at the Toronto International Film Festival on September 12. Starring Robert Redford as Dan Rather and Cate Blanchett as Mary Mapes, the film retells the Rathergate scandal based on Mary Mapes's memoir Truth and Duty. I must be one of the few people in the United States actually to have read the book. Mapes is the hero of her memoir and the hero of the film. »
Some call it "Truth" (2)
The film Truth premiered at the Toronto International Film Festival this last night. Based on Mary Mapes's memoir Truth and Duty, the film retells the Rathergate scandal from the perspective of Rather and Mapes. Rather and Mapes were perpetrators of a fraudulent story, but I take it that the film portrays them as heroes and victims. It is, after all, based on Mapes's ludicrous book and it stars Robert Robert »


text:
Cover art for the brazilian comics anthology "Revista A3". I did this last year (2009) and it was released just now. The concept is based on one story in the book called "Between the Shadows", written by Nando Alvez and illustrated by Eduardo Cardenas.
What was used to paint this illustration?
brilliant layout, coloring and over-all concept and execution, Mateus.
Que gostosa ein!
Muito show a composição.
Muito show a composição.
Finíssimo!!! Me lembrou algumas das composições do Travis Charest. Chiqueza total, rapaz, parabéns!
freakin' bananas!!!
Gorgeous cover!
muito foda
Santa tartaruken!

subset: commoncrawl


text:
Cardioscience (Cardioscience)
Current impact factor: 0.00
Impact Factor Rankings
|2016 Impact Factor
|Available summer 2017
|1997 Impact Factor
Additional details
|5-year impact
|Cited half-life
|Immediacy index
|Article influence
|Material type
|Document type
|Journal / Magazine / Newspaper
Publications in this journal
Article: The functional and metabolic responses of the heart to catecholamines are attenuated in diabetic rats.[Show abstract] [Hide abstract]
ABSTRACT: Many studies have shown that the contractile response of the rat left ventricle is impaired in diabetes mellitus. Few studies have examined the acute in vivo effects of catecholamines on the right ventricle of diabetic rats. The present study investigates the acute in vivo effects of norepinephrine (100 micrograms.kg-1.h-1 continuous intravenous infusion for 15 minutes) on the function of the right and left ventricle of diabetic rats. The effects of isoproterenol (25 mg.kg-1, subcutaneously) on the activity of glucose-6-phosphate dehydrogenase, the first and rate limiting enzyme of the oxidative pentose phosphate pathway, and on adenine nucleotide biosynthesis of the diabetic heart were also examined. Diabetes mellitus was induced by a single intravenous injection of streptozotocin (60 mg.kg-1) 4 weeks before measurements. The hemodynamic measurements were made on intact, anesthetized rats with Millard ultraminiature pressure tip catheters. The basal hemodynamic measurements (left ventricular systolic pressure, diastolic aortic pressure, left ventricular dP/dtmax, right ventricular systolic pressure and right ventricular dP/dtmax) as well as glucose-6-phosphate dehydrogenase activity and adenine nucleotide biosynthesis were the same in the diabetic animals as in the controls. Heart rate was slower in the diabetics. Norepinephrine, after 15 minutes of intravenous infusion, induced a marked increase in heart rate, left ventricular dP/dtmax, right ventricular systolic pressure and right ventricular dP/dtmax; whereas left ventricular systolic pressure and diastolic aortic pressure remained unchanged. Isoproterenol caused a pronounced stimulation of both cardiac glucose-6-phosphate dehydrogenase activity (after 24 hours) and adenine nucleotide biosynthesis (after 5 hours).(ABSTRACT TRUNCATED AT 250 WORDS)
Article: Incorporation of cholesterol oxidation products into cell lipids and their influence on the proliferation of cultured cardiomyocytes.[Show abstract] [Hide abstract]
ABSTRACT: We have investigated the incorporation of cholesterol oxidation products into cardiomyocyte lipids and related this to changes in cell proliferation, evaluated by measuring cellular protein content. Primary cultures of neonatal rat ventricular cells were supplemented with scalar concentrations of several cholesterol oxidation products (cholestan-5 alpha, 6 alpha-epoxy-3 beta-ol, 5 alpha-cholestane-3 beta, 5, 6 beta-triol, 5-cholesten-3 beta, 4 beta-diol, 5-cholesten-3 beta-ol-7-one, and 5-cholesten-3-one). Although all the cholesterol oxidation products were incorporated into the cardiomyocyte lipids when added to the medium at a concentration higher than 0.5 microM, the extent of the incorporation of the different cholesterol oxidation products differed, depending on the concentration in the culture medium and on the chemical structure of the compound. The effects of the cholesterol oxidation products on the cellular protein content were also different: 5 alpha-cholestane-3 beta, 5, 6 beta-triol was shown to be the most potent inhibitor of cell proliferation, followed by cholestan-5 alpha, 6 alpha-epoxy-3 beta-ol, 5-cholesten-3 beta, 4 beta-diol and 5-cholesten-3 beta-ol-7-one. 5-Cholesten-3-one did not affect the cellular protein content. The ability of cholesterol oxidation products to inhibit cell proliferation, and their capacity to increase the permeability of the plasma membrane to calcium, could be deleterious for cardiac cells.
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ABSTRACT: To determine the effects of chronic constriction of the left coronary artery on the function and structure of the heart, coronary artery narrowing was surgically induced in rats and ventricular pump performance, extent and distribution of myocardial damage, and the hypertrophic and hyperplastic response of myocytes were examined. Alterations in cardiac hemodynamics were found in all rats, but the characteristics of the physiological properties of the heart allowed a separation of the animals into two groups which exhibited left ventricular dysfunction and failure, respectively. Left ventricular hypertrophy occurred in both groups and was characterized by ventricular dilatation and wall thinning which were more severe in the failing animals. Multiple foci of myocardial damage across the wall were seen in all animals but tissue injury was more prominent in the endomyocardium and in failing rats. The anatomical and hemodynamic changes resulted in a significant increase in diastolic wall stress which paralleled the depression in ventricular performance. Myocyte cell loss and myocyte cellular hypertrophy were more severe with ventricular failure than with dysfunction. Finally, diastolic overload appeared to be coupled with activation of the DNA synthetic machinery of myocytes and nuclear mitotic division. In conclusion, a fixed lesion of the left coronary artery leads to abnormalities in cardiac dynamics with marked increases in diastolic wall stress and extensive ventricular remodeling in spite of compensatory myocyte cellular hypertrophy and hyperplasia in the remaining viable tissue.
Article: A subpopulation of intracardiac neurons from the guinea pig heart expresses substance P binding sites.[Show abstract] [Hide abstract]
ABSTRACT: The distribution of binding sites for substance P labeled with [125I]-Bolton-Hunter-reagent was studied in a mixed cell culture preparation from newborn guinea-pig atria and interatrial septum. A relatively small subpopulation of intracardiac neurons expressed substance P binding sites. These neurons exhibited a range of densities of labeling and could be heavily, moderately or lightly labeled with autoradiographic grains. In most cases, the autoradiographic grains were restricted to the neuronal cell body and more proximal regions of the neurites in culture. Intracardiac neurons expressing substance P binding sites were seen in close association with unlabeled neurons. The density of labeling and the distribution of autoradiographic grains over individual intracardiac neurons did not appear to be related to whether they were mono- or binucleate or their associated cell types. The possibility that the substance P binding sites demonstrated here represent functional receptors on intracardiac neurons and their potential role in the heart is discussed.
Article: The effects of distension of the stomach and the descending colon on phasic coronary blood flow in the anesthetized pig.[Show abstract] [Hide abstract]
ABSTRACT: Previous studies in anesthetized animals showed that distension of the stomach or the descending colon primarily caused decreases in mean coronary blood flow. Whether these responses occurred during systole or diastole was not investigated. The present work was planned to study the primary effects of the distension of the two viscera on phasic coronary blood flow in the anesthetized pig. In ten animals, the stomach and the descending colon were distended at constant volume by injecting warm Ringer solution into intravisceral balloons (0.8 and 0.25 l respectively) while preventing changes in heart rate and arterial blood pressure. Distensions of the stomach or the descending colon caused a decrease in mean coronary blood flow in each pig. However, the decrease elicited by gastric distension occurred only during diastole, while the decrease caused by descending colon distension involved both systolic and diastolic coronary blood flows. The same effects on phasic coronary blood flow were observed during experiments in which the decreases in mean coronary blood flow elicited by distension of the stomach or the descending colon were further augmented by adding the distension of the second viscerum. The results indicate that the coronary vasoconstriction caused by gastric distension mainly involves the vessels which supply the subendocardial layers of the myocardium, while that caused by descending colon distension also involves the vessels which supply the subepicardial layers. The vasoconstrictor effect on the subendocardial coronary circulation is enhanced by the combined distension of the two viscera.
Article: Exercises in (col)lateral thinking.
Article: Assessment of subrenal banding of the abdominal aorta as a method of inducing cardiac hypertrophy in the guinea pig.[Show abstract] [Hide abstract]
ABSTRACT: The aims of this study were to develop a model of left ventricular hypertrophy in the guinea pig using the technique of aortic banding below the level of the renal arteries, and to characterize any cardiac electrophysiological changes induced. Female guinea-pigs were either sham operated or the abdominal aorta was partially occluded by banding around a 23 or 25 G needle. Following recovery, animals were monitored for 10 weeks. The left ventricular dry weight to body weight ratio was similar in sham (0.326 +/- 0.01 mg/g, n = 12) and aortic banded guinea pigs (0.308 +/- 0.1 mg/g, n = 11). Conscious mean arterial blood pressure was also not modified by the aortic banding 10 weeks after operation (72 +/- 16 (sham) vs 71 +/- 1 mmHg). The action potential characteristics measured in isolated superfused left papillary muscle stimulated at 1 Hz were similar in sham and aortic banded groups. The action potential duration measured at 50 and 90% of repolarization tended to be longer in muscle from aortic banded (122.4 +/- 10 ms ADP50 and 155.2 +/- 9.5 ms APD90) than sham operated animals (105.8 +/- 8.4 and 142.2 +/- 6.2 ms) but these differences were not statistically significant. Hypoxia abbreviated the cardiac action potential to a similar degree in muscle from sham and aortic banded animals. It is concluded that sub-renal aortic banding with a 23 or 25G needle fails to develop left ventricular hypertrophy in the guinea pig 10 weeks after operation.
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ABSTRACT: The aim of the present study was to investigate stable left ventricular dysfunction resulting from severe myocardial ischemia in conscious dogs, in order to evaluate the action of cardiotonic agents under pathological conditions mimicking moderate cardiac failure. Mongrel dogs with a catheter implanted in the left ventricle were trained on a treadmill and subjected to a standardized exercise before and after a Harris-type ligation of the anterior descending branch of the left coronary artery in two stages. Two weeks later the lower third of the left circumflex coronary branch was also occluded, and the exercise test repeated for at least two additional weeks to evaluate the changes in the left ventricular function indicated by left ventricular systolic pressure, end-diastolic pressure, heart rate, positive and negative dP/dtmax and dP/dt/P. Noninvasive radionuclide investigations of the left ventricular function and myocardial perfusion were done before and after the development of cardiac failure. Following occlusion of the anterior descending and circumflex coronary arteries, the baseline end-diastolic pressure increased from 7.6 +/- 2.3 mmHg to 23.3 +/- 3.0 mmHg (p < 0.05) and increased even further during exercise (to 49.2 +/- 3.5 mmHg, p < 0.05). After the development of cardiac failure, no substantial change occurred in the end-diastolic pressure, either during rest or repeated exercise tests.(ABSTRACT TRUNCATED AT 250 WORDS)
Article: Dependence of the cardiac contractile force on the coronary perfusion pressure: difference between the isovolumic hearts of rat and guinea pig.[Show abstract] [Hide abstract]
ABSTRACT: We have compared the contractile responses of the isovolumic hearts of rat and guinea pig to a rise in the coronary perfusion pressure in the range 60-120 mmHg (Gregg's phenomenon). Left ventricular systolic pressure was lower in guinea pig hearts than in rat hearts at a low coronary perfusion pressure and increased markedly less at a higher perfusion pressure, despite a greater increase in coronary flow. The rise in left ventricular systolic pressure in the guinea pig hearts was entirely due to an increased left ventricular end-diastolic pressure, while left ventricular developed pressure did not increase. The wet weight of the hearts in situ was similar in both species, but after perfusion the guinea pig hearts gained significantly more fluid than the rat hearts (65% of the initial heart weight compared to 37%). The group of rat hearts perfused with a low external concentration of Ca2+ developed a similar left ventricular pressure to the guinea pig hearts and gained a similar amount of fluid (63%), but Gregg's phenomenon was the same as in rat hearts perfused with a normal concentration of Ca2+. The results suggest that the weak Gregg's phenomenon seen in guinea pig hearts can be attributed to factors other than myocardial edema and a lower left ventricular systolic pressure.
Article: Magnetic resonance relaxation times in ventricular hypertrophy induced by myocardial infarction in the rat[Show abstract] [Hide abstract]
ABSTRACT: The purpose of this study was to evaluate changes in the proton nuclear magnetic resonance relaxation times (T1 and T2) after chronic infarction in the rat. Ligation of the left coronary artery was followed by various degrees of reduction in myocardial blood flow. The ligation induced infarction in the left ventricle and compensatory hypertrophy in the right ventricle, as evaluated by the ratio of right ventricle to body weight. The interventricular septum and the right ventricle did not become ischemic in this model and served as control areas. In the infarcted left ventricle our results showed an increase in the T1 and T2 relaxation times after 15 and 30 days of ligation and a slight decrease after 60 days. A similar change in the T1 values was observed in the right ventricle. In contrast, a persistent increase in the T2 relaxation times was observed in the right ventricle and correlated with the ratio of right ventricle to body weight (r = 0.54, p < 0.01). The observation that the magnetic resonance relaxation times in vitro are modified in the hypertrophic right ventricle after myocardial infarction could be important in interpreting magnetic resonance imaging in vivo. There was no relation between the changes in the relaxation times and the degree of myocardial ischemia.
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ABSTRACT: To elucidate the vascular actions of lysophosphatidylcholine, we examined its effects on the concentration of cytosolic free calcium ([Ca2+]i), plasma membrane fluidity and release of lactate dehydrogenase in vascular endothelial cells cultured from bovine aortas. The [Ca2+]i of the endothelial cells was measured by a dual-wavelength fluorospectrophotometer using a fluorescent, calcium-specific indicator, Fura-2. Membrane fluidity was monitored by measuring changes in the steady-state fluorescence anisotropies, using 1,6-diphenyl-1,3,5-hexatriene as a fluorescence probe. In the presence of 1 mmol/L extracellular calcium, lysophosphatidylcholine caused a biphasic elevation of [Ca2+]i in Fura-2-loaded vascular endothelial cells, consisting of a large transient component followed by a relatively low, but more sustained component. At concentrations of lysophosphatidylcholine equal to or greater than 10 mumol/L, [Ca2+]i increased in a dose-dependent manner in the presence or absence of external calcium. In the absence of extracellular calcium, only an initial transient increment in the [Ca2+]i of endothelial cells was generated, the sustained component being eliminated. The sustained component was greatly depressed or almost abolished by the addition of the calcium influx blocker, NiCl2. Plasma membrane fluidity was greatly increased by incubation with lysophosphatidylcholine (30 and 50 mumol/L) concomitant with significant increases in the release of lactate dehydrogenase from the cells. At 50 mumol/L, lysophosphatidylcholine increased lactate dehydrogenase release and membrane fluidity in a time-related way.(ABSTRACT TRUNCATED AT 250 WORDS)
Article: Troponin I and T protein expression in experimental cardiac hypertrophy. Cardioscience 6:65-70[Show abstract] [Hide abstract]
ABSTRACT: We have examined four models of experimental cardiac hypertrophy and heart failure for alterations in troponin isoform expression, particularly in the re-expression of the fetal isoforms. Cardiac protein extracts from experimental and sham-operated control rats were analyzed using one dimensional gel electrophoresis, followed by Western blotting and detection with antibodies specific for troponin I and T. No alteration in protein profile was observed for these proteins between control, hypertrophied and failing heart samples. The data demonstrate that reversion to the fetal pattern of troponin expression is not a feature of experimental cardiac hypertrophy and heart failure in the rat.
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ABSTRACT: Treatment with propionyl-L-carnitine has been shown to increase the walking capacity of patients with peripheral vascular disease, but the mechanisms responsible for the effect are unknown. To study the effects of propionyl-L-carnitine on musculocutaneous vascular beds and the related mechanisms, a preparation of constant-pressure blood-perfused dog hind-limb was used. Since the propionyl-L-carnitine solution had a pH less than 4 the contralateral limb simultaneously received acidified saline. The substances were injected into the perfused arteries in 2 minutes or in 20 minutes, and the cumulative dose of propionyl-L-carnitine was 20 mg/kg for each administration. The preparation was well suited for this study, because there were no major systemic effects of propionyl-L-carnitine, nor signs of cross-circulation between the isolated limbs. Propionyl-L-carnitine increased flow by 130% in 2 minute infusions and by 49% in 20 minute infusions. Acidified saline increased flow by 47% in 2 minute infusions and by 34% in 20 minute infusions. The difference between propionyl-L-carnitine and acidified saline was significant in 2 minute infusions. The 2 minute infusions of propionyl-L-carnitine increased venous PO2 by 34% and PCO2 by 22% while pH decreased by 0.07. The 20 minute infusions of propionyl-L-carnitine increased PO2 by 22% and PCO2 by 24% while pH decreased 0.10 units. Acidified saline increased only venous PO2 in 2 minute infusions (16%). Calculated oxygen consumption of the perfused limbs increased in 2 minute infusions of propionyl-L-carnitine, but not significantly. It was concluded that propionyl-L-carnitine has a direct vasodilator effect in musculocutaneous vascular beds at high doses and probably enhances tissue metabolism.
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ABSTRACT: The aim of the study was to examine whether stimulation of alpha- and beta-adrenergic receptors in intact rats induces cardiac hypertrophy and to characterize the metabolic alterations that precede or accompany the process of hypertrophy. Cardiac beta-adrenergic receptors were stimulated with a single subcutaneous injection of 25 mg/kg isoproterenol. This led to an increase in the cardiac cAMP level which was followed by the sequential enhancement of adenine nucleotide biosynthesis and protein synthesis. The increase in adenine nucleotide and protein synthesis induced by isoproterenol was prevented by propranolol (50 mg/kg) within the first 5 hours. Norepinephrine, given as a continuous intravenous infusion of 0.2 mg/kg for 3 days, induced an increase in heart rate, mean aortic pressure and total peripheral resistance. Cardiac output was slightly reduced. The cardiac RNA/DNA ratio and the left ventricular weight/body weight ratio were significantly increased by about 40%. Simultaneous intravenous administration of the alpha-receptor blocker prazosin (0.1 mg/kg/h) and of the beta-receptor blocker metoprolol (1 mg/kg/h) reversed the functional changes and attenuated the increase in the RNA/DNA ratio induced by norepinephrine. The left ventricular weight/body weight ratio was within the range of the control values. Selective stimulation of alpha-adrenergic receptors by continuous intravenous infusion of norfenephrine (2 mg/kg/h) for 3 days increased heart rate and total peripheral resistance, while cardiac output was significantly lower. The RNA/DNA and left ventricular weight/body weight ratios were increased. Prazosin attenuated the increase in the RNA/DNA ratio induced by norfenephrine and prevented the development of cardiac hypertrophy. In the isolated perfused working rat heart, norepinephrine (3 x 10(-8) M) increased the expression of the proto-oncogenes c-fos and c-myc after 30 and 60 minutes, respectively. This increase occurred at about the same time as that induced by volume overload (increase of preload from 8 to 16 cm H2O) and pressure overload (increase of afterload from 80 to 100 cm H2O), but was more pronounced. In intact rats, norepinephrine elicited an increase in the mRNA and activity of glucose-6-phosphate dehydrogenase, the first and regulating enzyme of the oxidative pentose phosphate pathway, in a time-dependent manner. It is suggested that this may be part of a long-term homeostatic mechanism to keep the cardiac adenine nucleotide level in the normal range.
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ABSTRACT: A review of the birth locus and the first developmental stages of cardiomyocytes and Purkinje cells in the chick embryo is presented in the light of recent experimental results. Experiments done in vitro have shown that the stage of 2 somites is an important morphogenetic phase, characterized by mutual identification, selective adhesion and spatial organization of the putative cardiac cells of the splanchnopleural sheet in the cardiogenic area. Many experimental data suggest that the neural crest cells moving through the corridor of the dorsal mesocardium, as well as the cholinergic system related to them, may play a role of myogenic inductors on the mesothelial putative cardiac cells. In addition, other experimental findings suggest that the Purkinje cells of the conduction system may have a crestal origin. This hypothesis is well grounded, although the origin of Purkinje cells remains to be clarified.
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ABSTRACT: The mean coronary blood flow increases in response to an increase in myocardial oxygen consumption. Conversely, an increase in coronary perfusion is itself reported to induce an increase in myocardial oxygen consumption. Such an effect can be explained by stretching of the myocardial fibers surrounding the vessels, which become more distended with an increase in perfusion. The flow in the left descending and circumflex coronary arteries is reduced in systole because of the compression exerted by the contracting myocardium on the intramyocardial vessels. Due to the thinner wall of the right ventricle, this reduction is not obvious in the right coronary artery. The intramyocardial pump model provides a satisfactory explanation of the mechanism by which contraction reduces the flow. It also explains the attenuation of the diastolic-systolic oscillations of flow which occurs in the presence of a stenosis of a large epicardial artery. The varying elastance model shows the dependence of the extent of the reduction of the flow in systole on myocardial contractile force rather than on the pressure developed in the ventricle by the contraction. However, although the ventricular systolic pressure does not affect the flow in hearts with a relatively thick wall, it contributes to the systolic reduction of flow in hearts with a relatively thin wall. Owing to a mechanism involving the coronary capacitance, contraction is also responsible for the level of coronary flow in diastole.
Article: Influence of the phospholipid content in docosahexaenoic acid on electrophysiology and contraction of rat heart muscle cells[Show abstract] [Hide abstract]
ABSTRACT: The cardiovascular beneficial effects of fish oils are currently attributed to docosahexaenoic (C22:6 n-3) and eicosapentaenoic (C20:5 n-3) acids, although most investigations have focused on eicosapentaenoic acid. This study was devoted to the specific effect of docosahexaenoic acid, as compared to eicosapentaenoic acid, on the basal electrophysiological and mechanical characteristics of cultured rat myocardial cells. The myocyte cultures were prepared from newborn rat heart ventricles. The cells were grown for 24 hours in a conventional seric medium, and then incubated in a medium enriched with either docosahexaenoic acid or eicosapentaenoic acid for 96 hours. This treatment resulted in docosahexaenoic acid-rich cells (16% of the phospholipid fatty acids) and docosahexaenoic acid-poor cells (1.5%), both displaying the same phospholipid n-6/n-3 polyunsaturated fatty acid ratio. The transmembrane potentials were recorded with glass microelectrodes. Contractions were monitored photometrically. The action potential amplitude was slightly smaller in docosahexaenoic acid-rich cells (-4 mv), due to a lower plateau phase. There was no difference in action potential duration and spontaneous rate. The contraction measurements were not significantly different between the two groups of cells. We conclude that increasing the docosahexaenoic acid content in cardiomyocyte membrane phospholipids may have modulated the calcium ionic channels governing the plateau phase of the action potential, whereas the other physiological activities remained unaffected.
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.


text:
Lady Hagen Women's Essential Golf Polo
$22.50 $30.00*
Save $7.50 (25%)
Product Information:
Designed to give you cool comfort through hot and humid days, the Lady Hagen® Essential Polo wicks away moisture while protecting you from the sun's rays. For a premium look and maximum ventilation to your core, the fabric is ultra-lightweight and knit with a needlepoint texture. A classic fit paired with princess seams offers a flattering, tailored silhouette with ease through your torso for a motion-ready fit.
- Hydro-Dri™ technology wicks away moisture to keep you cool, dry, and comfortable
- UV protection to UPF 30
- Needlepoint texture
- Short sleeve polo
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- Made of 100% polyester
- Style: WGH11125
- Lady Hagen
Country of Origin: United StatesWeb ID: 17554536
Customer Reviews:
Rated 4.7 out of 5 by 401 reviewers.
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Rated 5 out of 5 by G Like the material & comfort of material Love the shirt. It washes well & doesn't need ironing. January 11, 2016
Rated 5 out of 5 by Avezan Love this shirt! I have 3 of these shirts. I wear them as a uniform for working as a referee. They are good fitting, long wearing and nicely tailored. They are perfect for hot sticky weather. They wash well and are a good price. December 4, 2015
Rated 5 out of 5 by Tanya Great sale find I love the fit and style of this shirt and I got it off the sale rack! GO ME! November 10, 2015
Rated 5 out of 5 by MaryanninFL Excellent fit, fabric and style. Excellent fit, fabric, style and color choices. Comfortable, looser fit compared to some of the newer top brands that have no ease for those of us who are less slim in the middle. I now own three! November 8, 2015
Rated 5 out of 5 by Pam2 Very comfortable and attractive fit. I loved it so much I bought 3 different colors.t This is such an attractive yet comfortable top that I bought 3 in different colors November 4, 2015
Rated 4 out of 5 by Fred Shirt Shirt was for my wife and she likes very much..... November 4, 2015


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Contents tagged with xaml
Review: Silverlight 1.0 Unleashed
I suspect that most ASP.NET developers would like to get started with Silverlight development. For most of us, it's a question of finding the time, overcoming some inertia, and getting over a touch of anxiety about the learning curve. Adam Nathan's Silverlight 1.0 Unleashed is a good way to get your fingers into Silverlight code and feel your way around - much the way you did when you first encounter any new platform.


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I am a friendly, open, fair and kind natured man. I am an IT-specialist, so if you have any technical problems with your computer or with your website, I can help you! Although I am sure that all this is done, so all the better! I do not like to sit still, but am very patient. My dream is to jump with a parachute! I also enjoy taking pictures. I love nature, biking, extreme sports, such as wake-boarding and rope-jumping, etc. I love people! Everyone is original, yet each a little bit crazy!


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Celebrating Mrs. West's birthday with some words of wisdom
"I feel odd when I don't wear makeup. I don't recognize myself." - Vogue
Listen to Kim Kardashian Radio on iHeartRadio
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OSTWARE SERVICES is a software development outsourcing company. We provide software engineering and testing services in the domains of Embedded systems, Telecommunication, and Multimedia.
At the beginning of 2014, OSTWARE SERVICES company, previously known as Toroki Ukraina, has undergone a rebranding process and entered a new stage of its development.
Our key values are experienced and skilled people, team spirit, and professional growth of our employees and the company in general.
Cooperation with some of the leading high-tech companies helps us comprehend the most up-to-date trends in the domain of embedded systems and related technologies. Throughout years of dedicated work, we have gained invaluable experience and developed good background knowledge in our niche areas. We have an in-depth understanding of software development processes and their establishment on practice.
We turn the passion and expertise of our software engineers into business success of our customers.
Providing solutions in the area of software engineering, OSTWARE SERVICES offers high quality services brought to you by experienced and skilled professionals. We have carried out many successful projects and thus gained deep expertise in the area of Embedded Systems software development.
Low-level software development can be tricky, but our team is used to tackling complicated and challenging tasks on a daily basis.
OSTWARE SERVICES team offers testing services for your software. Our quality assurance (QA) specialists can organize work process in remote labs, provide estimation of scope of work, resources, time, and assist you with setting a testing task.
We can develop a custom Test Automation Framework tailored specifically to your product. OSTWARE SERVICES QA specialists can conduct different types of testing, including regression testing and optimization, your product conformance, stress testing, system end testing, performance testing and others.
One of the most important stages of software development life cycle is the product usage, which requires timely support and assistance. OSTWARE SERVICES team offers a full range of support and maintenance services. We have all the necessary tools and practices for maintaining and supporting products of different types and levels of complication.
Our company OSTWARE SERVICES has joined the ranks of IT Cluster's members recently.
The crucial factor to enter the Cluster was our belief in the fact that only with joint efforts Ukrainians IT sphere will become more proffesional and successful. Due to dynamic growth and new high-tech projects, our Company's specialists gained considerable experience that we are willing and will be happy to share with our Lviv colleagues.
OSTWARE SERVICES has greate experiance in organization and conducting internal technical clubs and hackathons, which we are planning to organize outside the сompany opening ourselves to and sharing knowledge with the world.
Stepan Veselovskyi, CEO of Lviv IT Cluster, stated: 'Lviv IT Cluster is proud of the fact that our organization is constantly expanding with the help of such powerful companies as OSTWARE SERVICES. All of us clearly realize that positive changes in the IT sphere are possible only through maximum possible level collaboration. We are sure that our combined work will result in favorable results in the nearest future'.
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The Wall Street Journal reports that Dell will be installing Google software on "millions of Dell personal computers." That means software like Google Desktop search, the Google Toolbar, and the default search engine will be set to Google on these Dell PCs. Google is paying Dell an undisclosed amount for this partnership.
This is kind of funny, after Google making a big stink over IE7 defaulting to MSN Search. Microsoft uses the OS to compete, Yahoo teams up with eBay and Google now partners with Dell.
Postscript From Danny: Dell embraces Google from News.com has comments from Google out of an investors conference about the deal. And in light Google's complaints about IE7 not allowing choice, this quote from Dell doesn't really ring true:
Our motivation is to deliver customers tools that enable them to search and organize information quickly and easily, right out of the box…Dell customers will have the option of choosing Microsoft as their default if they prefer.
Yep — they just have to change the defaults in IE7, right? Except Google's argued that those defaults are too hard for mere mortals to alter. So consumers really have as much choice with the Dell deal as they have with IE7 — that is, as much or as little choice as you think they are technically capable of.


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Ask the Experts
wet kissDear Dr, 1 year before i had wet kiss one hiv positive women.after one month i have symptom fever, dry cough. this symptom hiv infected to me?after one year i tested elisa is negative.is reliable elisa test?pls tell me about the wet kiss.
Response from Joseph McGowan, M.D., F.A.C.P.
North Shore University Hospital...severe gum disease and active gum bleeding and one of the individuals had HIV. Even more reassuring for you is that you had an HIV test and it came back negative. Joe Read more »
HIV from deep kissing/dry humping?!Hi Dr. Bob,I'm a bit confused, just because I called the CDC hotline and the ansewrs more confused... Read more »
Deep kissing = Death Kissing?Hello Dr bob.Greetings from South Korea,one of my friend told me about your site and i found it an... Read more »
HIV Transmission...Prevention Information Network (NPIN)Web site , or call NPIN at 1-800-458-5231. To find a testing site near you, visit the National HIV Testing Resources Web site . Are patients in a health care setting at risk of getting HIV? Although HIV... Read more »
What Is AIDS?...infected with HIV, your body will try to fight the infection. It will make "antibodies" -- special molecules to fight HIV. A blood test for HIV looks for these antibodies. If you have them in your blood, it means that you have HIV infection.... Read more »
HIV Transmission...fluids in any context. Don't worry too much about rare cases. For instance, there is one documented case of transmission from deep or "French" kissing -- in two people who had terrible dental problems. However, the odds of getting HIV from... Read more »
HIV Testing...Confidential HIV Testing HIV Name-Based Reporting Partner Notification Orasure Test for HIV Rapid Tests for HIV Home HIV Antibody Tests Urine Test for HIV RNA / NAAT Testing For-Profit Test... Read more »
Connect With Others
Posted by Katietaylor, 1 Reply...being exposed. Two nights ago I met a man in a night club who I didnt know really well. One thing led to another and I let him deepkiss me a couple of times and finger me there was no oral or penetrative sex involved. 1.Can HIV be transmitted... Read more »
please help me. deep kiss and cuts .
Posted by ind234567, 2 Replies...India. 48 hours back i had protected sex with a girl whom i later 100% suspect of being HIV infected. during the sex, we had deep hard kissing for 5 minutes or so and it resulted in my lips getting minor cuts and scratches. now i believe the... Read more »
Deep Kissing
Posted by Anonymous, 2 Replies...I dont realy know how to explain, ive been deepkissing a girl in advanced hiv status, since that exposure that someone said theres now risk i have been with candidiasis, angular Read more »
22 poz..stopped taking meds/not disclosing status
Posted by Anonymous, 16 Repliesi was diagnosed hiv+ december 2003. i had an insane viral load of over a million. my initial cd4 was 280. i began taking medication and within 2 months i gained back the 50 pounds of weight i lost and became healthier than ive ever been before. i... Read more »