text:
After interviewing 6 doctors I choose Dr Dobkin.. He removed 3 discs in my neck and after a year of pain, well it's been 9 years since the operation and Ihave been ... Read more
Knowledgeable, approachable, personable... you couldn't ask for a better doctor to help guide you through a procedure as sensitive as brain surgery. On top of this, ... Read more
attentive. Compassionate. Professional. An outstanding doctor.
he did two surgeries on me and I'm still walking John Edison Vanderham
Dr. Ozgur is a very knowledgable Neurosurgeon. Dr. Ozgur is caring and so is his staff. I suffered with terrible back pain for over 10 years and after seeing Dr. O... Read more
Dr Schnitzer performed surgery in my lower back. The results were good. Recovery was excellent. He has a reputation for being a careful surgeon with minimal collat... Read more
I had a consultation with Dr. Devin Binder back in April 2013. I work in the medical field and I was already comprehensive of what my MRI said. He still spent an ent... Read more
Not good with follow up after operation, spent 8 days in hospital and felt ignored.
I was his patient UCI in southern CA. I want to be mature about this and just assume that my perception of his care is not a reflection on his overall professionalis... Read more
Mr. Abazari evades important questions, performs unecessary follow-up surgeries, refuses to get back with you in a timely manner, says he "forgets" what happened, ha... Read more
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Moonflower Cache Pot
5 Things I Wish Everyone Knew About JesusHere are five things everyone should know about the Son of God.
How Important Is Physical Attraction in a Relationship?We all know physical attraction is important in dating, but is it everything?...
Celebrities Who Went from Wealthy to BrokeThese celebrities thought they had it all until they went broke.
More from Beliefnet

subset: commoncrawl


text:
Exceptional Dental Offices
The management and staff of Exceptional Dental Offices, subscribes to "Patient Safety and Service First" and the methodology for achieving "Patient Compliant".
What is Patient Safety and Service First?
Establishing and maintaining a patient safety and service standard that far exceeds the industry and government standards. Many whom embrace mediocrity will think it is unnecessary and is "overkill", but to a few dental offices, patient safety and service is paramount, not an option.
What is Patient Compliant?
The standard of the office must be to deliver to every patient the highest quality of care, at the highest level of safety and service, no matter what it takes or no matter what the cost. This means surpassing the requirements that are set by government agencies like Consumer Affairs, Dental Board, the Centers for Disease Control and Prevention, the Department of Health Services and OSHA. The attitude of management and the staff is to keep moving the bar higher and never, never, never settle for less!
Commitment to "Excellence" means that management and staff fosters a burning desire to add value in everything they do and focus only on results. They have the willingness to become experts in the prevention of cross contamination and accept that their success is their responsibility.
Make no mistake, dentistry is healthcare and with potential exposure to diseases like Ebola, Measles, Hepatitis, Tuberculosis, Methicillin Resistant Staphylococcus Aureus and H1N1 Flu, just to name a few, there is no room for amateurs. Today, dental professionals must know more in order to do more, therefore are committed to ongoing education and skill development. They recognize that they must invest in themselves in order to help others. They never lose sight of the "Why" they do what they do – "for the patient".
Exceptional Dental Offices Can Prove it!
Only 2% of dental offices "Talk-the-Talk and Walk-the-Walk", they are the few that can make the claim of being "Patient Compliant", meaning safer for patients. It's Patient Safety and Service that you can see!
The dental offices that are listed, must qualify by engaging in active learning, yearly training and pass yearly onsite evaluation. It takes hard work, dedication and commitment to become an Exceptional Dental Office.
Exceptional Dental Office or Nothing
I have an advantage, I work with the management and staff of these offices, helping to guide them to a level far above government regulations and requirements. I personally witness their hard work and solid dedication to being the "Best". When it comes to safety and service, I cut no slack, in my mind you either make it or you don't. Therefore, the offices on my "Exceptional Dental Offices" list, are the dental offices where I myself would go to for dental healthcare. So if an office drops their standard, I drop them from the list!!
Tom Terry
To find an "Exceptional Dental Office" in your city – Just go to "Categories" at the upper right side of this page, pull down the menu and then locate your city.
Attention Patients – if your dental office is listed your comments are welcomed. Look for the "Leave A Reply Box" just below your dentist's listing, enter your comments and click the "Submit Comment" button – it's that easy!!
Attention Dentists – want to become an Exceptional Dental Office and be listed on this site? Send me an email: firstname.lastname@example.com
The dental offices that are listed, have passed patient safety and service requirements that exceeds both industry and government standards. It is based upon the dedication to excellence in patient care, safety and service that these offices are listed as "Exceptional Dental Offices" and not because of any form of compensation.


text:
Events Calendar
one campus many voices
advanced search
Event Detail Information
Event Detail Information
Thought Amidst Waste: Politics in Shack Settlements in South Africa
Richard Pithouse lectures in Politics at Rhodes University in Grahamstown, South Africa.
Knight Auditorium, Spurlock Museum
Department of History-World Histories from Below initiative, with support from IPRH, George A. Miller Visiting Scholars Program, Sociology, Geography, Urban and Regional Planning, Center for African Studies, Center for Global Studies, University YMCA.
Kathryn Oberdeck
Richard Pithouse, a South African scholar, journalist and activist with the Durban shack dwellers' movement Abahlali baseMjondolo, will talk about the political history of shack settlements in South Africa and contemporary shack dwellers' struggles as they illuminate the prospects for emancipatory politics among the poor.
Other events:
Mon. Mar. 4 "Urban and Housing Activism From Below," panel discussion with visiting scholar Richard Pithouse
313 Gregory Hall, 3pm
Mon. Mar. 4 "Dear Mandela" film screening with discussion
7:30 PM, University YMCA, 1001 S. Wright St.
Fri., Mar. 8 "Dear Mandela film screening, with discussion
7:30 PM, University YMCA, 1001 S. Wright St.
Sat., Mar. 9 Champaign Public Library, Robeson Rooms
10 AM Room B "DEAR MANDELA" discussion and Skype discussion with Abahlali Members (or online free streaming through Feb. 28 on AfroPop: http://video.pbs.org/video/2328714078/
2 PM Rooms A&B Community Panel on "Community Knowledge" in Durban and South Africa, addressing environmental justice, immigrant issues, incarceration, etc.


text: Le Fontanelle serves seafood. That's really it. Seafood, seafood, and more see food and they do a kick @$$ job of it. It's the best bang for your buck in Gallipoli for seafood. I have been going their for 2 years. You need a reservation during the summer months for sure. Do not be surprised if... read more


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Evolving Depths by MikkoLagerstedtWatch
©2014-2016 MikkoLagerstedt
Correct me if I'm wrong but is this picture mirrored? Really pretty though
impressive capture! thank you for sharing!
The sky looks gorgeous.
This could be a great music album cover
Stunning beauty! Thank You
I love the color and composition of your work. It has a depth of introspection that as an observer makes me wish to look more, longer and draws me quite literally into the scene created. I really come back to look more to see what I missed, as if the work is some prized memory I want to reinspect.
Wow, this is awesome. Wonderful shot!
love it.
Wow, I'm curious to know how many hours of work went into this shot
Very beautiful shade of blue!
Beautiful shot.
This is a gorgeous piece!
great tones and sky details
beautiful photo.
Great long exposure!
wow i'm amazed
great job !
great job !
Wow. This is a beautiful shot.
Nicely done!


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Mary Frances Fresh Start Evening Bag
$225.00 Original Price $300.00
Savings: $75.00 (25%)
A crisp, clean white beautifully showcases incredible handmade flowers for an on-trend look with Eastern influences.
- 8.5-in. x 3-in. x 3.5-in.
- Snap closure
- Interior credit card pocket
- Antique brass hardware
- Shoulder strap
- Pvc/Man Made
- Imported
Shipping & Returns
Shipping your purchase is easy on belk.com. Depending on the destination of your package, you can expect it to arrive within 4-7 business days. Shipping Information
Returns are easy on belk.com. Easy returns


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Marmot Pants
About Marmot Pants:
Here at Moosejaw, we try and get by on a pants-optional lifestyle whenever possible. And maybe that's a success some of the time, but unfortunately there's a good many instances where we're very unfortunately forced to cover up those legs of ours. Naturally, there are times where pants are an absolute given, like when you're on your way up the ski lift, or ready to trudge through that unexplored trail in the dead of winter. Whatever activity you're ready to get into, Marmot has the pants for the job.
Well, pretty much any activity. Might be impossible to claim we know how well they can handle things like circus performing or marathon ping pong games, but our best guess? They'll handle it all super well. Performance is the key word here, with Marmot throwing together a collection made to complement your lower half whether your plan is to strike the slopes or face that climb in inclement weather. All of this, accompanied by some impressive first-class tech and you have yourself pants that are second to none, and just might change our mind on that whole no-pants thing.
The PreCip pants, flagship of the Marmot pants line, are best-sellers for a reason – waterproof to ensure you stay dry while dealing with pesky elements, made extra breathable so you never overheat. Easily packable, side zippers at the ankle make them easy to throw on in an emergency situation. But the PreCip is just one part of the assortment, with a number of other pairs built ready for whatever you might face. Be it pants built for a premium level of movement and agility, or stock with top-notch insulation to keep you warm when it gets wildly cold, those stems of your will be covered for it all. Let that adventurer spirit free, and embrace the pants-mandatory life – it's a lot easier to do when Marmot is making them.
Check Out More Marmot Pants:


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Advanced Search
Sharp Electronics Corp.'s Notevision C30 is a compact LCD projector with a brightness of 1,700 ANSI lumens and an XGA resolution. Its portable design makes it well suited for mobile presenters, and Sharp's PresenterPAK feature set offers quick and easy setup, simple image adjustment and enhanced presentation options. It features a graphical user interface menu screen that is icon based and color-coded. A number of image-adjustment features allow presenters to fine-tune images both automatically and manually. The projector also offers a versatile selection of outputs and inputs, including a monitor out port, a computer/RGB output, two data inputs and one video input for composite video or S-video. By connecting through an RS-232 port, users can remotely control and diagnose projector problems via a PC. Sharp Electronics Corp., Mahwah, NJ, (201) 529-8200, www.sharp-usa.com.
This article originally appeared in the 02/01/2001 issue of THE Journal.
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Find out why over 900 educators in 48 states say they could be better equipped for emergencies – and what stands in their way. Plus, learn how your school can improve safety, emergency preparedness and everyday efficiency in this just-released report. Download the results and see how your school communications compare.
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Fujifilm CP49E P1-S Developer Start Up, 4.3L
The Fujifilm CP49E P1-S Developer Start Up is specifically designed for use in Frontier 710 and 750 minilab processors.
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text:
Death and Return of Trunks 3 by NazaruWatch
©2008-2016 Nazaru
Heres the 3rd page to my comic. Check the 1st page for more info.
Deviant Art
Amazing Spiderman 2 Review
When I did my review of the Amazing Spiderman, I said that I deeply loved the film. As oppose to the Raimiman films, which the kindest thing I could say would be to quote Norman Osborn in this movie, "We can do better. We deserve better." I saw the Amazing Spiderman 2 on opening day, and it surpassed all my expectations. Unfortunately a good chunk of the public disagrees with me. While still being in the minority. The people that hate the movie were enough to give it scores of 55% on RT, and 73% on IMDB. All the while boasting how superior Raimiman 2 was. Even going so far as to say that Raimiman 3 was better. Saying things like, "At least Raimiman 3 had character arcs and a plot, Amazing Spiderman doesn't have that. Amazing Spiderman 2 has no heart (The last sentence said by the bias Raimitard Trillbeereviews)." That is bullshit. Amazing Spiderman 2 does have character arcs and plot, and far better ones than any of the Raimiman movies. Especially Raimiman 2. Raimiman 2 SUCKED! It had
|Sta.sh Submit


text:
Jul 15
Showa from 7-11pm the line up is : Elizabeth and Chloe, Good thing im Incompetent, Oh Inquirer, Momo Morgenn, Young Blake TcYb Riccard , GENTZ, Picking Up Napoleon
Sounds Like: God Is An Astronaut, Animals As Leaders
Label: unsigned
Bio: Booking email: firstname.lastname@example.com
Momo Morgenn began guitar in 2005 after first being influenced by acts such as Foo Fighters, Korn, and System of a Down. Momo first joined bands along the years throughout school. After little success in musical groups Momo f...See Full Bio
"Enjoyed my visit and really like your sound. I wish you only the best here on Reverbnation and in all you do."


text:
Advance your skills and learn advanced techniques in subjects such as computer programming where you'll write code using vb.net. You'll also create relational databases using MS Access; create a website using HTML and Javascript and advance your business application skills using MS Word, Excel and MYOB.
There's every reason to step up your learning in information and communication technology. Better yet, this certificate provides an excellent base for further study with the Certificate in Networking and Desktop Support, or the Bachelor of Information & Communications Technology (Applied).
Palmerston North
22 February 2016 - 1 July 2016
25 July 2016 - 2 December 2016
Please enquire for details.
Palmerston North
Semester One timetable information.
Programme materials will be issued at the start of the programme. You may be asked to pay for lost or damaged books.
© Copyright UCOL 2009NZ GOVERNMENT FUNDED INSTITUTE OF TECHNOLOGY ESTABLISHED 1902Our website was designed by Greg Mackay, BAVI Graduate 2008


text:
William J. Seare, MD
a user ...
a user ...
Ratings based on 12 reviews
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Are you a patient of William J. Seare, MD?
Reviews (12)
5 out of 5 stars Brazilian Butt Lift
dr. seare is a true artist... - Carlsbad, CA
Show More Dr. Seare is a true artist...
New Me Soon to Be. - Carlsbad, CA
Show More He is very professiona and takes the time to answer any questions you might have. He also took the time to put all my concerns and anxiety to rest about if this was the right procedure for me.
5 out of 5 stars Mommy Makeover
38 Year Old, Mini Tummy Tuck, Fat Transfer to Breast, Fat Transfer to Under Eyes. Carlsbad, CA
5 out of 5 stars Breast Fat Transfer
Fat Transfer to Breasts, Face, Bootie, and Vag - Carlsbad, CA
Show More Dr. Seare was caring and meticulous. From the consultation all the way to post op care he never wavered in his dedication and craft.
5 out of 5 stars Fat Transfer
Getting a Younger Body. Carlsbad, CA
Show More Dr. William Seare is a wonderful, caring, patient, and extremely skilled doctor.
5 out of 5 stars Liposuction
55 Years Old and Hopeful to Reduce Pear Shape. Carlsbad, CA
Show More So far, Dr. Seare has been the consummate professional. He is extremely dedicated to his craft. He has worked hard to educate me with respect to realistic expectations for my body and age. Now that it is 13 days post op, and I am healing and getting a glimpse of the results, I can attest to Dr. Seare's skill and artistry. To date, I am very happy with the results of all of the procedures performed, full thigh lipo (360 degree, hip to knee) and fat transfer to my face and breasts. I expect I will be thrilled in 3 months when the more permanent results are visible. It was an incredible experience to be conscious and awake during surgery. The team kept me informed of each step of the process and we often discussed details regarding why a particular technique was used. I am so grateful to have been able to witness the the tremendous level of skill and excitement Dr. Seare brings to his leading edge lipo techniques, as well as his dedication and the tireless 10 hour effort he put forth to give me the absolute BEST possible result. In my opinion, Dr. Seare is a true healer, a masterful artisan, a learned scientist, and a wonderful human being. I am very thankful I selected him as my physician.
5 out of 5 stars Liposculpture
30 Year Old Male, 360 Lower Torso Fat Removal by Liposculpture. Carlsbad, CA
Show More Dr. Seare has been very supportive and caring up to this point and seems to care for me as he would if I was his nephew. I am just hoping that the care continues throughout the procedure.
5 out of 5 stars Liposuction
Changed my Life! - Carlsbad, CA
Show More I really feel like a new person, no longer have to struggle finding something to fit me in the am for work, and no longer have to unzip my jeans in order to fit my belly, I have a flat belly and waist now!!!! my new look help my confidence, make me feel more comfortable, free to do more, happy to face life, and help a lot with my depression, I'm not longer taking any medication and feel more better about life! Thank you Dr. Seare you change my life!
5 out of 5 stars Fat Transfer
Age 53 Male with Older-looking Face - Carlsbad, CA
Show More Dr. Seare is warm, caring, and very experienced. He really loves doing surgery and helping people improve their looks-- see his eyes light up when he talks about it. He spends as much time as you need. Some weeks he is very busy and may have multiple consults, meaning you may have to wait past your scheduled appointment. On surgery days or when he has several consults it can be hard to get ahold of him by phone. Try to avoid this by asking staff for a slow day, otherwise, while waiting remind yourself that when it's your turn he won't rush you, he'll take the time to understand you and your desires.
5 out of 5 stars Liposculpture
Liposculpture with Fat Transfer - Carlsbad, CA
Show More Dr Seare has an excellent bedside manner. You can tell he really cares. He does this to help people improve self esteem, which can improve quality of life. He's direct and honest, and tries to work with any budget.
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Top Definition
One who is excessively gassy and continuously emits feces smelling farts.
"Ugh, that ain't dookie, that's just Kevin, he's a gassy ole stank tail!"
by Isabella.Fontain June 15, 2009
Type your email address below to get our free Urban Word of the Day every morning!
Emails are sent from firstname.lastname@example.com. We'll never spam you.×


text: Featured comments + Add comment Comments (1) Featured BitbyDeath "Maxis used to make tons of new franchises until 1997 which coincidentally is when EA bought them. Will Wright was a great developer but now he's reduced to cloning the same games over and over again. Welcome to EA Hell. " 1031d ago


text:
The world is a twisted place. A friend of ours used to make a lot of money selling used knickers online to pervy businessmen.
Girls' Pubes goes one better. We provide real pubic hair from real girls, direct to your door. These things don't come cheap, so we're currently in the R&D phase. Full website with secure payment is under construction - watch this space!
This domain is for sale!
Wanna make a fortune?
Buy this domain name
email: email@example.com


text:
Fraphne Overload by LazyPerfectionWatch
©2013-2016 LazyPerfection
So I was watching the new Scooby-Doo movie Stagefright and at the very end.. BAM! Smoochy lmao It was a great movie though.
'bout time they kissed. How many years has it been?
This movie just aired on Cartoon Network actually this past weekend; yep, Fred/Daphne pairing fans probably had a field day with the movie, and with this scene as well.
Lol Even after a month I still enjoyed it
Yep; I saw it for the first time on Cartoon Network Saturday and I thought it was pretty good.
How did you watch this movie it hasn't come out yet?!


text:
realmagick.com The shrine of knowledge.
- (Note that in this definition the meaning of valence is equivalent to Thus trimethylborane and methyllithium react to form the ate compound Me4B-Li+.
- Preparation of High Purity Trimethylborane
- The preparation of high-purity trimethylborane is described. Impurities Trimethylborane is a toxic, reactive gas (bp —20 liberate the trimethylborane gas.
- nvl.nist.gov
- Description of torsional motion of identical tops in trimethylborane
- the trimethylborane molecule are described by the geometrical group. (1) construction is outlined for the example of the trimethylborane molecule B(CH3)3.
- www.springerlink.com
- Description of torsional motion of identical tops in trimethylborane
- www.springerlink.com
- Organoboron compounds 334. Complexes of trialkylboranes with
- www.springerlink.com
- Trimethylboron (TMB)
- Jul 21, 2006 Synonyms: Trimethyl borane, trimethyl borine, TMB. Manufacturer: Voltaix, LLC.
- www.voltaix.com
- Deoxygenation Without Tin
- Wood and Spiegel reasoned that they could slow the reaction further by substituting trimethylborane for triethylborane. To their surprise, not only did the fragmentation not occur, but deoxygenation occurred again.
- Dinosaur Farts Caused Sauropodogenic Global Warming, Says Study
- A new study, Could Methane Produced by Sauropod Dinosaurs Have Helped Drive Mesozoic Climate Warmth?, [PDF] in Current Biology suggests that dinosaur flatulence may have boosted global average temperatures by as much as 18 degrees Fahrenheit ...
- Trimethylborane - Wikipedia, the free encyclopedia
- Trimethylborane is a toxic compound normally occurring as a gas that spontaneously catches fire in air.
- en.wikipedia.org
- Preparation of High Purity Trimethylborane
- The preparation of high-purity trimethylborane is described. Impurities Trimethylborane is a toxic, reactive gas (bp —20 liberate the trimethylborane gas.
- nvl.nist.gov
- Trimethylborane - Chemical Entity Data Page
- www.chemthes.com
- TRIMETHYLBORANE (593-90-8) - LookChem.com
- Find quality suppliers and manufacturers of TRIMETHYLBORANE for price inquiry.
- www.lookchem.com
Trimethylborane is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Trimethylborane books and related discussion.
Suggested Pdf Resources
Suggested News Resources
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Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
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Summer Crafts for Kids
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Crocheted Flag on a Jacket
By: Kreinik
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Give your child's denim jacket a face lift for the 4th of July. This crocheted flag on a jacket features metallic threads for the stripes and buttons for stars, the perfect July 4th craft for a child to wear.
- size E crochet hook
- One 10m spool of Canvas #24 Braid in color 3506 Blue Samba
- Three 10m spools of Canvas #24 Braid in color 003 Red
- One spool each Kreinik Cord in 003C Red and 105C Antique Silver
- Several star buttons, vintage buttons, or plain white buttons
Note - modify the pattern as needed, adding chains or rows, to fit your denim jacket
- Make two small Red Stripes as follows:
Row 1: Chain 16, turn
Row 2: Skip first chain, then single crochet in each chain, chain two, turn
Row 3 and 4: repeat row 2
- Make one large red stripe following the same pattern above, except chain 31.
- Make one Blue Square as follows:
Row 1: Chain 11, turn
Row 2: Skip first chain, then single crochet in each chain, chain two, turn
Rows 3 - 9: repeat row 2
- Using Kreinik Cord, sew each crocheted piece onto the back of your denim jacket in a flag shape (see photo for guide).
- Attach buttons as desired on the blue square.
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text:
Stephen Greenblatt (Author, Harvard University)
"Greenblatt knows more about [Shakespeare] than Ben Jonson or the Dark Lady did."—John Leonard, ?Harper's
A young man from a small provincial town moves to London in the late 1580s and, in a remarkably short time, becomes the greatest playwright not of his age alone but of all time. How is an achievement of this magnitude to be explained? How did Shakespeare become Shakespeare? Stephen Greenblatt brings us down to earth to see, hear, and feel how an acutely sensitive and talented boy, surrounded by the rich tapestry of Elizabethan life, could have become the world's greatest playwright. A Pulitzer Prize and National Book Award Finalist.
Ninth Edition / Paperback
Volume(s): 1 / Middle Ages:Restoration and Eighteenth Century
Ninth Edition / Ebook
Volume(s): One-Volume
Intent upon letting the reader experience the pleasure and intellectual stimulation in reading these classic authors, the How to Read series provides a context and an explanation that will facilitate and enrich your understanding of texts vital to the canon.More


text:
Are you Yong-Feng Liu?Claim your profile
Publications (26)16.85 Total impact
- [Show abstract] [Hide abstract]
ABSTRACT: Aims and background: Hepatobiliary cystadenoma and cystadenocarcinoma are rare cystic lesions of the liver. The aim of the study was to discuss the clinical features, diagnostic methods and surgical treatment of hepatobiliary cystadenoma and cystadenocarcinoma in our hospital. Methods: Six patients with hepatobiliary cystadenomas and four with hepatobiliary cystadenocarcinomas were evaluated. We collected detailed clinical data, and all patients were followed. Results: Three patients of the 6 with cystadenomas and 2 patients of the 4 with cystadenocarcinomas had marked elevation of CA19-9 (average, 707.0 U/ml and 1078.5 U/ml, respectively). CT scan with contrast revealed typical lesions in all 10 cases, i.e., cyst-occupying lesions with separations in the liver. All patients with hepatobiliary cystadenoma were treated by partial hepatectomy. None of them recurred at a mean follow-up of 40 months. Three patients with hepatobiliary cystadenocarcinoma underwent hepatectomy, without recurrence or metastasis at a mean follow-up of 32 months. Conclusions: Tumor markers (CA19-9) and imaging findings may be helpful for an early diagnosis. Complete resection is still the best choice. Even for hepatobiliary cystadenocarcinoma, considering the low malignant grade, we suggest that for the best prognosis radical excision should be attempted.
Article: Colorectal Liver Metastases Rarely Occur in Patients with Chronic Hepatitis Virus Infection[Show abstract] [Hide abstract]
ABSTRACT: There are studies that report that liver metastases rarely occur in patients with cirrhosis. This study evaluates the relationship between the incidence of liver metastases from colorectal cancer (CRC) and chronic hepatitis virus infection in patients. Three hundred and fifty-four cases of advanced CRC from our hospital were evaluated. The patients were divided into a chronic hepatitis virus infection group and a non-hepatitis virus infection group. The two groups were compared regarding the incidence of colorectal liver metastases and survival. The criterion of colorectal liver metastases was based on liver CT examination and intraoperative exploration results. There were two cases with colorectal liver metastases among the seventy cases of the chronic hepatitis virus infection group. The rate of liver metastases was 2.86%. There were 48 cases with colorectal liver metastases among 284 cases of the non-hepatitis virus infection. The rate of liver metastases was 16.9%. The incidence of colorectal liver metastases between the two groups was significantly different (p<0.01). Five-year survival rates were 60% and 40.8% in the chronic hepatitis virus infection group and the non-hepatitis virus infection group, respectively (p<0.05). The degree of progress in the two groups of patients showed no significant difference. Colorectal liver metastases occur rarely with chronic hepatitis virus infection and the patients in our study had good prognoses.
Article: Localization of Small Sized Insulinoma by Means of Combining Arteriography with CT: a Case Report and Review of the Literature[Show abstract] [Hide abstract]
ABSTRACT: The majority of pancreatic insulinomas are of small size and conventional imaging examinations such as percutaneous ultrasonography (US), Computerized Tomography (CT) and MRI usually fail to reveal the lesion. In this article we describe the potential role of combining arteriography with CT, which is superior to single arteriography or CT. A 45-year-old man who suffered from significant catecholaminergic and neuroglycopenic symptoms, such as hypodynamia, sweating, impaired memory and confusion, was diagnosed with insulinoma by biochemical tests. The serum level of glucose of fast in the morning was as low as 1.2 mmol/L, coincident with the low serum level of glucose; the serum level of insulin was 28.77 mIU/L. The fasting insulin-to-glucose ratio was higher than 0.4. The C-peptide of 1097.62 pmol/L was higher than normal. The lesion was not identified on US, CT scan or arteriography. However the combination of arteriography with CT revealed the small insulinoma located at junction of the body and the tail of the pancreas, about 1.0 x 0.8 cm. Intraoperative ultrasound (IOUS) verified the lesion which located in the posterior and superior aspect of the pancreas and spleen-preserving distal pancreatectomy was performed. Histopathology confirmed the diagnosis. After the surgery the patient underwent a good recovery and was discharged two weeks later. He has developed no further episodes of hypoglycemia two years after the surgery. Combining arteriography with CT is a valuable examination for insulinoma, and IOUS is helpful to verify the lesion. Entire excision of the lesion is the best way of treatment.
Article: [Correlations between MELD score and left ventricular function in patients with end-stage liver disease].[Show abstract] [Hide abstract]
ABSTRACT: To evaluate the correlations between MELD score and left ventricular function in patients with end-stage liver disease. A total of 92 patients who prepared for orthotopic liver transplantation from January 2002 to May 2008 were enrolled in this study. Of these Patients, 75 were males and 17 were females, and the mean age was 50.3+/-9.5 years; 85 were cirrhosis, 7 were cirrhosis with primary liver cancer. Preoperative information, including biochemical parameters, coagulation parameters, indicators of hepatitis virology, two-dimensional echocardiography and electrocardiogram were collected. According to MELD (the Model for End-stage Liver Disease) scoring system, these subjects were categorized into three groups: MELD score is less than or equal to 9 points (31 cases, 33.7%); 10 is less than or equal to MELD score is less than or equal to 19 points (45 cases, 48.9%); MELD score is more than or equal to 20 points (16 cases, 17.4%). The relationships between MELD score and classification and cardiac function were determined by chi-square test, analysis of variance, rank sum test and correlation analysis, et al. MELD score was significantly correlated with left atrial diameter (LAD), interventricular septum thickness (IVST), left ventricular end-diastolic diameter (LVEDD), aortic flow (AF), cardiac output (CO), QRS interval (QRSI) and corrected QT interval (QTc) (r = 0.317, 0.341, 0.228, 0.387, 0.325, 0.209 and 0.347, respectively; P value less than 0.01, respectively); except QRSI, these variables and left ventricular posterior wall thickness (LVPWT) were also correlated with INR (a MELD component) (r = 0.282, 0.319, 0.322, 0.435, 0.275, 0.320 and 0.237, respectively; P value less than 0.01, respectively); LAD, LVEDD, AF, CO and QTc were correlated with serum total bilirubin (r = 0.241, 0.219, 0.357, 0.246 and 0.253, respectively; P value less than 0.05, respectively); IVST and E/A ratio (A blood flow [from left atrium to left ventricular] velocity ratio between early diastole [E wave] and late diastole[A wave] ) were correlated with serum creatinine (r = 0.216 and -0.343; P value less than 0.05 and 0.01); the proportion of E/A is less than or equal to 1 in all subjects was 46.7% (43/92), and 48.4% (15/31), 35.6% (16/45) and 75.0% (12/16) in each group, besides, there was statistically significant difference between 10 is less than or equal to MELD score is less than or equal to 19 points group and MELD score is more than or equal to 20 points group (X2 = 7.359, P = 0.009). There are different degrees of left ventricular structure, function and electrophysiological changes in patients with end-stage liver disease, these anomalies also will be increased with the MELD score increasing.
Article: [Clinical analysis of autoimmune pancreatitis: a single center study of 14 consecutive cases].[Show abstract] [Hide abstract]
ABSTRACT: To investigate the characteristic findings of autoimmune pancreatitis (AIP) to increase the recognition of AIP. From February 2002 to April 2008, a total of 14 cases of AIP were reviewed by clinical, imaging, serologic, histopathologic features and treatment response. There were 13 male and 1 female, with a mean age of 53 years. The main clinical manifestations included progressive obstructive jaundice in 11 cases, upper abdomen pain in 3 cases. Diffuse enlargement of pancreas and diffuse narrowing of the main pancreatic duct (MPD) were observed in 11 cases, while 3 patients showed localized pancreatic head enlargement and focal narrowing of the MPD. Distal common bile duct stenosis was found in all cases. Increased expression of serum immunoglobulin G was found in 7 patients. Autoantibody test was positive in 5 of 12 patients. Nine of 14 patients with AIP had extrapancreatic organ involvement. Massive lymphocytes and plasma cells infiltration in pancreatic tissues were showed on pathology, as well as parenchymal fibrosis. Seven earlier patients were treated initially with surgical laparotomy or resection for suspected malignancy. Steroid therapy was given to the other patients and was responsive. There were 4 recurrences after initial treatment. AIP should be a differential diagnosis in pancreatic head mass in order to avoid unnecessary resection.
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ABSTRACT: To investigate the effect and mechanism of cytokine and inducible nitric oxide synthase on apoptosis and function of rat pancreas islets cultured in vitro. Islets from Wistar rats were cultured in vitro and divided randomly into four groups: blank control group, cytokine group of islets cultured with TNF-alpha+IL-1beta, aminoguanidine (AG) group of islets cultured with aminoguanidine, and AG + cytokine group of islets cultured with TNF-alpha+IL-1beta and aminoguanidine. The nutrient fluid nitric oxide level and islets cNOS/iNOS activity were detected by test kit and the expressions of iNOS mRNA and apoptosis related gene (Bax, Bcl-2) were evaluated by RT-PCR. The viability of the islets was examined by AO/EB staining and the function of the islets was detected by insulin secretion index assay. After co-cultured with cytokines IL-1beta and TNF-alpha, the expression and activity of iNOS in islet tissues enhanced (38.93+/-4.72) U/mL and the concentration of NO in medium increased remarkably(313.0+/-35.4) mol/L.The survival rate of cells and the insulin secretion index decreased with the up-regulation of proapoptosis gene and down-regulation of anti-apoptosis gene. But the activity of cNOS remained unchanged. Aminoguanidine reduced the cell apoptosis and increased the survival rate and insulin secretion index, and the activity of iNOS was inhibited. iNOS plays an important role in the apoptosis of islets cultured by cytokines TNF-alpha and IL1-beta. Aminoguanidine prevents the islets from the damage of iNOS, alleviates the impairment of cytokines to islets, lessens the cell apoptosis and ameliorates the survival and function of islets.
Article: The effect of iNOS gene expression inhibited by RNA inference on the pancreas islet apoptosis and function in rats[Show abstract] [Hide abstract]
ABSTRACT: To investigate the effect of iNOS gene on cell apoptosis and insulin secretion of pancreas islet in rats by RNA inference (RNAi). Islets obtained from thirty Wistar rats were randomly divided into five groups, and siRNA oligo was purchased from Genepharma in Shanghai. The cultured islets were transfected with iNOS siRNA, and then were divided into five groups. Islet cultured only was taken as blank control group, and cultured with TNF-alpha + IL-1 beta as cytokine group. Islet transfected with negative or iNOS siRNA were taken as negative transfection control group or RNAi group, while that transfected with iNOS siRNA and cultured with TNF-alpha + IL-1 beta as RNAi + cytokine group. Expression of iNOS mRNA was evaluated by RT-PCR and iNOS protein was evaluated by Western blot to detect the effect of RNAi. The expression of apoptosis correlated gene, Bax, Fas were analyzed, and the apoptotic cells were identified by TUNEL method meanwhile. Insulin secretion index assay the function of the islets. 500 - 600 IEQ islets could be extracted from every rat. RNAi attenuated the expression of iNOS and restrained the synthesis of iNOS protein.With treatment of cytokines IL-1 beta and TNF-alpha, the level of iNOS increased remarkably, the expression of Bax and Fas ascended distinctly, and insulin secretion index decreased strikingly. While, the expression of apoptosis gene and amount of apoptotic cells descended in group of RNAi + cytokine, and insulin secretion index were satisfying. The apoptosis from cytokines to islets mediated by iNOS could be suppressed by RNAi, which leaded to favorable function and survival of islets.
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ABSTRACT: To summarize the experience in the managements of portal vein thrombosis (PVT) and to evaluate the impact of PVT on intraoperative course and postoperative outcome in liver transplantation. Between May 1995 and September 2007, 194 orthotopic liver transplantations were performed, of which 24 cases presented portal vein thrombosis. There were 12 patients with grade I, 9 with grade II, 2 with grade III and 1 with grade IV. The management of PVT depended mainly on its extent. Ligation of the collateral circulation, especially spontaneous or surgical splenorenal shunt, was made as approaches to improve portal flow.Heparin or low-molecule-weight heparin as a prophylactic anticoagulation therapy was maintained during and after operation if prothrombin time is less than eighteen seconds. Follow-up Doppler ultrasonography was used daily in the early postoperative period. Risk factors and variables associated with the transplant and the post-transplant period were analyzed and compared with 170 patients transplanted without PVT. Surgical techniques were eversion thromboendovenectomy in 21 patients with PVT grades I and II, extra-anatomic mesenteric graft in 2 with grade III, and anastomosis to a collateral vein in 1 with grade IV. The study demonstrated more RBC transfusions [(15.2 +/- 11.8) U vs. (8.6 +/- 6.6) U, P = 0.006], longer surgery procedures [(492 +/- 89) min vs. (403 +/- 105) min, P = 0.001] and hospital stay [(32.4 +/- 13.5) d vs. (22.1 +/- 9.1) d, P = 0.001] in the PVT group. However, there were no differences in overall morbidity (58.3% vs. 50.6%, P = 0.478), hospital mortality (8.3% vs.6.5%, P = 0.73) and 1-year survival (87.5% vs. 89.4%, P = 0.778). The incidence of rethrombosis was higher in the PVT group (8.3% vs.1.2%, P = 0.021). Two cases rethrombosis were successfully cured by percutaneous thrombolysis, balloon angioplasty, and stent placement. Portal thrombosis is associated with greater operative complexity and rethrombosis, but has no influence on overall morbidity and mortality in liver transplantation.
Article: [Prevention and treatment of biliary complications following orthotopic liver transplantation].[Show abstract] [Hide abstract]
ABSTRACT: To study the prevention and treatment of biliary complications after orthotopic liver transplantation. Clinical data of 183 recipients who had received liver transplantation between May 1995 and December 2006 were retrospectively analyzed. Biliary complications occurred in 15 patients (15/183, 8.2%). The incidence for short-term and long-term complication were 6.0% (11/183) and 2.2% (4/183) respectively. No biliary complications was due to hepatic artery thrombosis(HAT). Four cases who received PTC(percutaneous transhepatic cholangiography) with stent insertion,8 cases who received ERCP( endoscopic retrograde cholangiopancreatography) with stent insertion and 1 who received Roux-en-Y choledochojejunostomy for anastomotic stricture were successfully cured. Two cases required relaparotomy died for fungus infection eventually. The mortality due to biliary complications was 1.1%. The rapid combined abdominal organ harvesting technique could shorten the ischemia time and ameliorate the injury due to vascular and bile duct variances, which could reduce the incidence of biliary complication. PTC and (or) ERCP combined with stent insertion were main procedure for biliary complications not related to HAT after liver transplantation.
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ABSTRACT: T h e t r e a t m e n t o f h e p a t i c m e t a s t a s i s i s a very difficult problem in tumor treatment. Although there are more therapeutic methods now available, the cure rate is still not very satisfactory. Metastatic liver cancer prognosis depends on the site of the original tumor, the degree of malignancy, the involvement of the liver, and extrahepatic metastases in patients with systemic conditions. Patients with Advanced liver metastasis of the tumor, can only be treated with a comprehensive treatment consisting mainly of surgical methods that can improve the quality of life and prolong survival. This paper reviews the progress in the treatment of hepatic metastasis.
Article: Protective effect of inducible nitric oxide synthase inhibitor on pancreas transplantation in rats[Show abstract] [Hide abstract]
ABSTRACT: To investigate the effect of inducible nitric oxide synthase inhibitor, aminoguanidine, on pancreas transplantation in rats. A model of pancreas transplantation was established in rats. Streptozotocin-induced diabetic male Wistar rats were randomly assigned to sham-operation control group (n = 6), transplant control group (n = 6), and aminoguanidine (AG) treatment group (n = 18). In the AG group, aminoguanidine was added to intravascular infusion as the onset of reperfusion at the dose of 60 mg/kg, 80 mg/kg, 100 mg/kg body weight, respectively. Serum nitric oxide (NO) level, blood sugar and amylase activity were detected. Nitric oxide synthase (NOS) test kit was used to detect the pancreas cNOS and inducible NOS (iNOS) activity. Pancreas sections stained with HE and immunohistochemistry were evaluated under a light microscope. As compared with the transplant control group, the serum NO level and amylase activity decreased obviously and the evidence for pancreas injury was much less in the AG group. The AG (80 mg/kg body weight) group showed the most significant difference in NO and amylase (NO: 66.0 +/- 16.6 vs 192.3 +/- 60.0, P < 0.01 and amylase: 1426 +/- 177 vs 4477 +/- 630, P < 0.01). The expression and activity of tissue iNOS, and blood sugar in the AG (80 mg/kg body weight) group were much lower than those in the transplant control group (iNOS: 2.01 +/- 0.23 vs 26.59 +/- 5.78, P < 0.01 and blood sugar: 14.2 +/- 0.9 vs 16.8 +/- 1.1, P < 0.01). Selective iNOS inhibitor, aminoguanidine as a free radical, has a protective effect on pancreas transplantation in rats by inhibiting NO and reducing its toxicity.
Article: Elevation of vascular endothelial growth factor production and its effect on revascularization and function of graft islets in diabetic rats[Show abstract] [Hide abstract]
ABSTRACT: To determine whether the elevated vascular endothelial growth factor (VEGF) expression produced by the transfected vascular endothelial cells (VECs) could stimulate angiogenesis of the graft islets and exert its effect on the graft function. Thirty diabetic recipient rats were divided into three groups (n=10 per group). In the control group, 300 IEQ islets were transplanted in each rat under the capsule of the right kidney, which were considered as marginal grafts. In the VEC group, VEC together with the islets were transplanted in each rat. In the VEGF group, VEC transfected by pIRES2-EGFP/VEGF165 plasmid and the islets were transplanted in each rat. Blood glucose and insulin levels were evaluated every other day after operation. Intravenous glucose tolerance test (IVGTT) was performed 10 d after the transplantation. Hematoxylin and eosin (HE) staining was used to evaluate the histological features of the graft islets. Immunohistochemical staining was used to detect insulin-6, VEGF and CD34 (MVD) expression in the graft islets. Blood glucose and insulin levels in the VEGF group restored to normal 3 d after transplantation. In contrast, diabetic rats receiving the same islets with or without normal VECs displayed moderate hyperglycemia and insulin, without a significant difference between these two groups. IVGTT showed that both the amplitude of blood glucose induction and the kinetics of blood glucose in the VEGF group restored to normal after transplantation. H&E and immunohistochemical staining showed the presence of a large amount of graft islets under the capsule of the kidney, which were positively stained with insulin-6 and VEGF antibodies in the VEGF group. In the cell masses, CD34-stained VECs were observed. The similar masses were also seen in the other two groups, but with a fewer positive cells stained with insulin-6 and CD34 antibodies. No VEGF-positive cells appeared in these groups. Microvessel density (MVD) was significantly higher in the VEGF group compared to the other two groups. Elevated VEGF production by transfected vascular endothelial cells in the site of islet transplantation stimulates angiogenesis of the islet grafts. The accelerated islet revascularization in early stage could improve the outcome of islet transplantation, and enhance the graft survival.
Article: [Effects of blocking the CXC chemokine receptor 3 pathway on acute rejection of islet allograft].[Show abstract] [Hide abstract]
ABSTRACT: To identify the effect of PNA CXCR3 on acute rejection of islet allograft. The mice islet transplant models were used. The mice were divided into three groups including saline group, PNA CXCR3 group and mismatch PNA group. In vitro the proliferation capability of T cell was assessed by proliferative responses. RT-PCR and western blot were used to detect the expression of mRNA and protein. Flow cytometry was applied to determine the expression level of CXCR3 in spleen CD3(+) T cells. Compared with saline [(6.72 +/- 1.48) d] and PNA mismatch-treated recipients [(6.54 +/- 0.86) d], PNA CXCR3-treated recipients demonstrated statistically significant prolongation [(9.70 +/- 1.57) d] in functional allograft survival. The CXCR3 mRNA expression level of PNA CXCR3 group (1.06 +/- 0.07) was significantly down-regulated compared with saline (1.98 +/- 0.22) and PNA mismatch (1.87 +/- 0.10) group at the 7th day after transplant. The date showed that CXCR3 protein and lymphocytes proliferation capability was significantly down-regulated in PNA CXCR3 group compared with saline and PNA mismatch group (P<0.01). The present study indicates that PNA CXCR3 can inhibit T cell activating and prolonging the survival time of islet allograft and has a substantial therapeutic effect on inhibiting acute allograft rejection.
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ABSTRACT: To explore methods of preventing and reversing rejection after simultaneous pancreas-kidney (SPK) transplantation. Seventeen patients underwent SPK transplantation from September 1999 to September 2003 were reviewed retrospectively. Immunosuppression was achieved by a triple drug regimen consisting of cyclosporine, mycophenolate mofteil (MMF), and steroids. Three patients were treated with anti-CD3 monoclone antibody (OKT3, 5 mg x d(-1)) for induction therapy for a mean period of 5-7 days. One patients received IL-2 receptor antibodies (daclizumab) in a dose of 1 mg x kg(-1) on the day of transplant and the 5th day posttransplant. One patient was treated with both OKT3 and daclizumab for induction. No primary non-functionality of either kidney or pancreas occurred in this series of transplantations. Function of all the kidney grafts recovered within 2 to 4 days after transplantation. The level of serum creatinine was 94 +/- 11 micromol/L on the 7th day posttransplant. One patient experienced the accelerated rejection, resulting in the resection of the pancreas and kidney grafts because of the failure of conservative therapy. The incidence of the first rejection episodes at 3 months was 47.1% (8/17). Only the kidney was involved in 35.3% (6/17); and both the pancreas and kidney were involved in 11.8% (2/17). All these patients received a high-dose pulse of methylprednisone (0.5 g x d(-1)) for 3 days. OKT3 (0.5 mg x d(-1)) was administered for 7-10 days in two patients with both renal and pancreas rejection. All the grafts were successfully rescued. Rejection, particularly acute rejection, is the major cause influencing graft function in SPK transplantation. Monitoring renal function and pancreas exocrine secretion, and reasonable application of immunosuppressants play important roles in the diagnosis and treatment of rejection.
Article: Effects of nitric oxide on reperfusion injury following pancreaticoduodenal transplantation in rats[Show abstract] [Hide abstract]
ABSTRACT: To investigate the effects of nitric oxide (NO) on reperfusion injury following pancreaticoduodenal transplantation in rats. The homologous male Wistar rat model of heterotopic total pancreaticoduodenal transplantation was used. The L-arginine (L-Arg) group received intravenous injection of L-Arg 5 minutes before and after reperfusion at a dose of 200 mg/kg while the N-Nitro-L-Arginine methyl ester (L-NAME) group received intravenous injection of L-NAME at a dose of 10 mg/kg, and control group received saline. The amount of NO in the pancreas graft was measured. Serum concentration of cytokine-induced neutrophil chemoattractant (CINC) determined by enzyme-linked immunosorbant assay, expression of CINC mRNA detected by Northern blot assay, and myeloperoxidase (MPO) activity in the pancreas graft were measured. Histological observation was performed. The amount of NO in the L-Arg group was higher than in the control group, while in the L-NAME group was lower than in the control group (P < 0.05). The peak of serum CINC concentration occurred 3 hours after reperfusion with significant difference among groups. Expression peak of CINC mRNA in the pancreas graft occurred 3 hours after reperfusion. The expression level in the L-Arg group was lower than in the control group, the L-NAME group was higher than control group (P < 0.05). MPO activity in the L-Arg group obviously decreasd compared with other groups. The pancreas inflammation was ameliorated in L-Arg group, and pancreas damage was aggravated in L-NAME group. L-Arg can increase the amount of NO and inhibit the elevation of CINC, CINC mRNA expression, and early neutrophil accumulation in the transplanted pancreas. NO has protective effects on the ischemia/reperfusion injury of pancreaticoduodenal transplantation.
Article: Influence of hepatitis B and hepatitis C virus infection on the outcome of kidney transplantation[Show abstract] [Hide abstract]
ABSTRACT: To investigate the impact of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection on the long-term survival of renal transplantation recipients. A total of 443 patients who received renal allografts from 1992 to 2002 were analyzed. Outcome and survival were compared among four groups retrospectively. Twelve patients were positive for both hepatitis B surface antigen (HBsAg) and HCV antibody (anti-HCV) (group 1), 18 were HBsAg-positive and anti-HCV-negative (group 2), 26 were HBsAg-negative and anti-HCV-positive (group 3) and 387 were negative for both markers (group 4). The mean follow-up period was 6.1 +/- 2.8 years (range, 0.5-10 years) for all patients. Group 2 had significantly higher liver-related complications (38.9%) and liver-related death (16.7%) than did group 4 (0%, P < 0.01). Among all patients, 4 HBsAg-positive patients had fulminant hepatitis and died within two years of transplantation. Three patients (group 2) who died were seropositive for HBeAg and/or HBV DNA and none had a history of or positive serologic marker to indicate hepatitis of other etiologies. One (group 1), two (group 2), and one patient (group 3) developed liver cirrhosis respectively, and hepatocellular carcinoma occurred in two patients (group 2) and one patient (group 3). Despite high liver-related mortality in HBV-infected patients, no significant differences among the four groups in the long-term graft and patient survivals were demonstrated. The presence of HBsAg or anti-HCV was not associated with poor prognosis as determined by Cox regression analysis. HBV or HCV infection is not a contraindiction to kidney transplantation in Chinese patients. However, it should be noted that serious liver-related complications may occur and limit survival in patients infected with HBV and/or HCV after kidney transplantation.
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ABSTRACT: Islet transplantation is considered a potentially curative treatment for diabetic mellitus. The aim of this study was to assess the feasibility of islet transplant through the spleen. Both donor and recipient Wistar rats (BW150+/-20 g) were provided by the Animal Center of China Medical University, Shenyang, China. Islets were isolated and purified with the modified Minnesota program. 600-800IE graft islets were handpicked and transplanted through the spleen of diabetic recipients. Blood glucose and insulin were evaluated after operation every other day. IVGTT was performed 10 days after transplantation. 300-400IE islet was procured from one donor rat. Secretion index (SI) of the glucose stress was 5.59+/-0.62, showing the graft functioning well. The diabetic rats restored normal blood glucose levels of 3.4-5.4 mmol/L (mean 4.8 mmol/L). Their insulin levels were as normal as 8.5-12.2 microIU/ml. The K value of IVGTT in the rats after transplantation was similar to the normal one. The islets can be transplanted successfully through the spleen, while avoiding the complications caused by traditional transplantation through the portal vein, such as bleeding and portal vein hypertension. The graft islets loss can be reduced because of less centrifugation and mechanic pressure. In conclusion, transplantation through the spleen is a simple and feasible method.
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ABSTRACT: CMU-1 is a new preservation solution with a low potassium concentration as well as low viscosity that is highly effective in reducing preservation injury. The purpose of this experiment is to compare the protective effect of CMU-1 solution with that of UW during cold preservation and normothermic reperfusion. Wistar rats were divided into two groups according to different preservation solution: CMU-1 group and UW group. After 6, 12 and 24 h cold storage of rat liver in different preservation solutions, the isolated perfused rat liver model was applied to reperfuse the liver for 120 min normothermically (37 degrees C) with Krebs-Henseleit solution, meanwhile the pH value of the preservation solution was measured. The perfusate was sampled for the evaluation of alanine aminotransferase (ALT) and lactate dehydrogenase (LDH). At the end of the reperfusion, all of the bile product was collected, energy metabolic substrate and histological examination were performed. After preserving for 6 h, pH value of both groups did not change; after 12 h, both decreased but with no significant difference. After 24 h, pH value in UW solution group significantly decreased. The total adenine nucleotides level and AEC in liver tissue decreased with preservation time, but they were higher in CMU-1 group. And the amount of bile product after perfusion for 120 min in CMU-1 group was much more than that in UW group. However, there were no significant differences in ALT and LDH levels between two groups. Histology showed no difference. The preservation effect of CMU-1 solution is similar with that of UW solution. However, CMU-1 solution shows some advantages over UW solution in energy metabolism, preventing intracellular acidosis and bile product.
Article: [The changes of Oddi sphincter motility after canine pancreas transplantation with bladder drainage].[Show abstract] [Hide abstract]
ABSTRACT: To study the changes of canine Oddi sphincter (SO) function after pancreas transplantation with bladder drainage and the effect on the graft function. Normal canine SO, transplant canine SO and canine SO in vitro manometry were performed by triple lumen catheter. At the same time, pancreas endocrine and exocrine function after transplantation were determined. After transplantation, anti-reflux function of graft SO was also measured. Endocrine and exocrine function of all the transplanted dogs showed that pancreas graft function was good. Basal pressure of SO in control group was (18.5 +/- 2.8) mm Hg (1 mm Hg = 0.133 kPa). The contraction frequency was (9.7 +/- 1.5) per min, the contraction amplitude was (47.1 +/- 5.5) mm Hg, the motility index was (236 +/- 56). After transplantation, basal pressure increased to (27.8 +/- 2.8) mm Hg, frequency increased to (13.1 +/- 1.9) per min, amplitude decreased significantly to (8.3 +/- 1.8) mm Hg. There was no significant difference of motility index. Basal pressure of SO in vitro increased significantly to (37.2 +/- 5.1) mm Hg. Phasic contraction was not absent. After transplantation, the pressure in the bile duct residual did not increase in accordance with the increase of bladder pressure. After pancreas transplantation with bladder drainage, Basal pressure and frequency of canine SO could increase while amplitude could decrease, which provide the anti-reflux function of graft SO and may serve as an obstacle to pancreatic juice flow.
Top Journals
China Medical University (PRC)Feng-t'ien, Liaoning, China
Guangzhou Medical UniversityFeng-t'ien, Liaoning, China


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At my appt yesterday when the girl weighed me, she didn't even look at the scale to see if it was level. She just slid the weights down to some arbitrary number and wrote that number down. That number was 162. I stopped her and said no, I don't weigh that much. She argued with me that that's what the scale said. I told her, you didn't even look at it, it wasn't level.
So I did it myself and got 158. Yeah, I only gained 3 lbs in the last 2 weeks, not 7. Now, I'm not sooooo concerned with the weight, but I still want the numbers to be accurate. If I gained 7 lbs in 2 weeks the dr might think something is wrong. I knew she was way off bc I've had acid reflux for like a month and can barely eat solid foods, there was no way I gained 7 lbs in 2 weeks.
Moral of the story: watch the staff, they get in a hurry and just write any old thing down. And also, don't be afraid to speak up when you know something isn't right.


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Mt. Whitney Coffee Roasters, Organic Ground Coffee, Shade Grown Peru, Medium Roast, 12 oz (340 g)
By Mt. Whitney Coffee Roasters5 Reviews
Expiration Date:?Nov 2016
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The length of time for the expiration date or "best used before" date depends on the type of product, as well as the brand.
Perishable items (such as flax oils or certain probiotics) generally have shorter expiration dates. Although our warehouse is fully air-conditioned, these more fragile items are put in cold storage (freezer or refrigeration unit) for maximum freshness.
Our receiving department does its best to verify and then enter the correct expiration dates for all incoming products. However, discrepancies do occur from time to time. This being said, the exceptionally high turnover at iHerb ensures that our inventory is among the freshest in the industry.
Shipping Weight:?0.95 lbs (0.43 kg)
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- Product Code: MWC-00401
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- Package Quantity: 12 oz (340 g)
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The best coffees in the world are a joy to the mind and soul. Brew a wonderful cup, sit down, and take a sip.
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Location · So. America
Roast · Medium
Flavors · Sweet, dark chocolate, clean, floral, lightly acidic, smooth
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100% High Grown Arabica Medium roast Ground Coffee
iHerb Customer Reviews
I love coffee that is fresh and not bitter. This shade grown (organic too) is incredibly smooth while remaining rich, sweet and deep in its taste. You feel like you have had a great cup of coffee that is balanced and satisfying. This is really good coffee. Thanks Mt Whitney for delivering a quality product. I give you an A+ P.S.
I liked it for being organic, but beside that it was nothing special.


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This Week in Photography – news from 25-31 August
Welcome to our weekly photography news, with all the latest stories that matter to serious photographers.
Selfie-friendly Olympus PEN E-PL7 unveiled
Olympus has unveiled the Olympus Pen E-PL7. This 16.1Mp metal-bodied compact system camera features a selfie-friendly LCD that "flips down and around so you can frame and shoot a series of pre-timed, sequential still or video selfies without your hand blocking the shot," according to Olympus.
The E-PL7 also includes a 3-inch, touchscreen LCD, 3-axis image stabilisation and built-in WiFi, which also enables the camera to be controlled via a smartphone.
The PEN E-PL7 goes onsale in late September for £499.99 and includes a 14-42mm f/3.5 pancake zoom lens. Read our head of testing's Olympus PEN E-PL7 hands-on review here.
Pentax K-S1 DSLR revealed
Pentax has revealed a new DSLR called the K-S1, with a 20Mp APS-C sensor and an LED body illumination that stays green when shooting stills but changes to red when shooting movies. More conventional features include an ISO range of 100-51,200 and a maximum shutter speed of 1/6000sec.
There is a slightly bizarre choice of colours based on Pentax's 'Fabric' range, including tweed grey, which will doubtless appeal to members of the aristocracy, and denim, which will doubtless appeal to Iron Maiden fans.
New Fujifilm X30 premium compact unveiled
Fujifilm has released a new premium compact, the X30, featuring a 12Mp, 2/3-inch CMOS sensor. The camera replaces the X20 and also includes an articulated (but not touchscreen) three-inch screen and an improved electronic viewfinder, featuring 2.36 million dots and a display time lag of only 0.003 seconds.
The lens has a fast aperture range of f/2-2.8 and 4x optical zoom. There is also a manual control ring to adjust aperture and shutter speed, and 12 frames per second continuous shooting mode.
Fujifilm claims the battery can now shoot 470 images on a single charge. The X30 goes onsale in late September for £479 and comes in black or silver. Click here to read our testing team's Fuji X30 hands-on review.
New Manfrotto travel tripod
The Befree Carbon, a new Manfrotto carbon fibre tripod for travel photographers and others needing lightweight support, has been launched.
The BeFree Carbon weighs only 1.1kg while its foldable legs reach a folded length of just 40cm. Such portability doesn't come cheap though, and the new tripod costs £279.95.
DxO Optics Pro 9.5.2 update
Version 9.5.2 of DxO Optics Pro has been released, with the Elite Edition adding support for the highly acclaimed Nikon D810 SLR. The DxO Optics Modules library has also been expanded, and now offers 894 new camera/lens combinations.
Click here for more information on the Standard and Elite editions of DxO Optics Pro v9.5.2 for Mac and Windows.
What camera should I buy? Pros and cons of each camera type
49 awesome photography tips and time savers
99 common photography problems (and how to solve them)
77 photography techniques, tips and tricks for taking pictures of anything


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Seems my airport is not working (direct connect is fine) I got a message in my antivirus software that reads- path: /net/localhost infection details:Error 60 Operation timed out. What does this mean and can you help?
I do not use Airport.
/net/localhost is empty on my Leopard.
I suspect that either Airport is misconfigured or your anti-virus software is causing a problem.
Does Airport work with anti-virus turned off?
Retrieving data ...


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Don't miss this hilarious version of Alfred Hitchcock's classic thriller! Almost 60 kids have been working on this for months. Bring the family – it's not too scary!
We can hardly wait!
It won't be long now! We're getting ready for our second big show and I think it's safe to say that you won't know what hit you! We're working our socks off to put together a production that you'll remember for a long time. We're very excited to be partnering with some ridiculously talented friends from all over to make this show like a giant, fun party with cake and everything, just for you!
All ticket sales are at the door to keep it simple for all of us. Please leave a response here or leave a message at 872-4961 if there's any information you need.
We can't wait to see you and show what we've been working on!
Coming in April – A Midsummer Night's Dream!
Once again, the All Purpose Theater Company is getting ready to knock your socks off, theatrically speaking!
A Midsummer Night's Dream is one of Shakespeare's most beloved and funniest plays. It's set in Athens, Greece, but we've pulled a little switch and dragged it into 1939 Athens, MAINE! You'll love what these kids are working on for you; and as always, there are several surprises that we don't think you'll see coming.
We'll be performing at the Blessed Hope Church at 10 Pleasant Street in Waterville again. Here are the dates to save:
April 4 – evening show
April 5 – matinee and evening show
April 11 – evening show
April 12 – matinee and evening show
Watch this page for developing info – and come be dazzled and delighted in April!
Variety Show poster


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How to draw an Orbot by Tesla-CoilsWatch
©2012-2016 Tesla-Coils
I made a quick ref on how to draw Orbot. I noticed a lot of people on tumblr drawing him recently so I wanted to help educate a little bit *v*
Thanks, I need to learn draw to orbot. How cute?
Hey, thanks so much for this! I'm doing a drawing of all different Sonic characters, and wanted to include Orbot. But I always have trouble getting him proportionally right, so this was just what I needed. Great step-by-step that really simplifies his design. I originally didn't include him in my drawing, but I had to; Orbot's such an awesome character
Now to devote a whole page to Orbot doodles~
Classy tutorial for classy people.
For real though, you did a great job detailing the steps to draw him and all.
For real though, you did a great job detailing the steps to draw him and all.
Oh yes, this is amazing~!


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Rick Steves, Salzburg: Gemütlichkeit elicits dreams of lederhosen and dirndls
In Mozart's home town, visiting the composer's haunts, enjoying a bicycle tour of von Trapp sights and poring over a marionette performance of The Magic Flute
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Recently, on one busy day, I revisited highlights and found new sights in Salzburg, a Baroque showpiece. Austria's fourth-largest city, at 150,000 residents, is divided into old and new. The Old Town, between the Salzach River and Salzburg's mini-mountain (Mönchsberg), holds nearly all the charm and most of the tourists. The New Town, across the river, has the train station, a few sights and museums, and some good accommodations.
I started my day in the New Town checking out the new displays and audio tour at Mozart's Residence, the reconstructed home of Salzburg's most famous citizen. (It's reconstructed because the house was bombed during the Second World War.) When Wolfgang Amadeus Mozart was 17, his family moved to these lavish digs. Here, you can see Mozart's piano and violin, among other artifacts. Die-hard classical music fans can also visit the cramped apartment of Mozart's Birthplace (Geburtshaus) in Old Town, where he learned to play piano and violin and composed his first boy-genius works.
In 1756, little Wolfgang was baptized at Salzburg Cathedral, one of the first Baroque buildings north of the Alps, in the heart of Old Town. For the next 25 years, this would be his home church. At a morning Mass, I enjoyed a bird's-eye view of the musical action of a choir and small orchestra. From a dizzying perch, I faced the loft, where for two years of Sundays, Mozart served as organist. Baroque scrolls, dancing cupids, and conductors' batons swirl like icing on a musical cake.
Today, Salzburg's most prominent citizen is quite a contrast to Mozart; he's the energy-drink tycoon Dietrich Mateschitz, a.k.a. Mr. Red Bull. He has a mysterious mansion at the edge of town, sponsors local soccer and hockey teams, owns several chic Salzburg eateries and cocktail bars, and employs 6,000 mostly good-looking people. It seems his personality is like the beverage that made him rich and powerful: a high-energy, anything's-possible cultural Terminator.
You can celebrate Red Bull right by the Salzburg airport in Hangar-7, where 20 or so of Mateschitz's glittering planes and race cars are housed under a modern steel-and-glass dome, along with several pretentious bars, cafés, and restaurants all designed to brandish the Red Bull "culture." The dynamic vibe extends into these eateries: Mayday Bar serves experimental food, and the pricey restaurant Ikarus features a different well-known chef each month.
I opted, instead, for a traditional schnitzel lunch at a restaurant, and then worked it off on a Sound-of-Music bicycle tour. The eight-mile scenic pedal through Salzburg plays up city sights related to the musical von Trapps, a Salzburg family who fled the Nazis. It's called "Fraulein Maria's Sound of Music Tour," but it's run by a burly young man named Rupert. Though they're schmaltzy, I've enjoyed the bus tours on previous visits, but the cycling version of this quirky tourist phenomenon was a new and good experience for me.
After biking, I took in a marionette performance of The Magic Flute. Marionette shows are a Salzburg tradition. (Think of the "Lonely Goatherd" scene in The Sound of Music.) Of all the musical shows in Salzburg that I recommend, this was one I'd never actually experienced before, and the performance (with handy superscripts in English) was spellbinding. A troupe of 10 puppeteers, actors themselves, brings to life the artfully created puppets at the end of their five-foot strings.
After the show, I hopped in a taxi and headed to the Augustiner Bräustübl (Augustiner beer garden) for my favourite dinner in Salzburg. This huge 1,000-seat beer garden within a brewery run by monks is rustic and raw, and packed with all generations, enjoying fish grilled on sticks, munching radishes artfully sliced into long delicate spirals, and hoisting tall gray porcelain mugs of beer drawn from old-time wooden kegs.
It seemed half of Salzburg had gathered under a chestnut tree orchard of conviviality.
German-speakers have a word for that kind of ambience: gemütlichkeit, which perfectly captures this kind of cozy conviviality that can make you dream in lederhosen and dirndls.
In the late hours, I checked out a string of boomer-friendly cocktail and wine bars on a very characteristic old lane in a tranquil section of town, a block off the river on Steingasse in New Town. Before returning to my hotel, I marvelled at the beauty of floodlit, castle-topped Salzburg from the riverbank.
Even after decades of travel, I'm amazed at how a single well-organized day can amass plenty of lifelong memories. Mingle with the locals, take a stroll or bike ride through the cobbled streets and elegant buildings, and enjoy the new and old of this Austrian mecca!
Rick Steves writes European travel guidebooks. Email him at firstname.lastname@example.com and follow his blog on Facebook.
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Los Angeles transformed this alley in North Hollywood into a polka dotted pedestrian plaza
Wednesday, March 4, 2015
Sam Lubell.
The first project in LADOT's People Street program has opened in a former alley near corner of Magnolia and Lankershim Boulevards in North Hollywood. The project, called NoHo Plaza, has been repurposed with cafe tables, chairs, umbrellas, a colorful surface treatment (which looks almost exactly like the dotted green and gold surface of Silverlake's Sunset Triangle Plaza), and perimeter planters.
New Public Space Initiative Aims to Revive Austin's Forgotten Alleyways
Tuesday, November 5, 2013
Agathe Dorel.
Austin, Texas–based architects Dan Cheetham and Michelle Tarsney have given a new face to some of the city's underutilized spaces: alleyways. Their one-of-a-kind community art installation, 20ft WIDE, seeks to resolve conflict between architecture, art, and humanism in order to create places of lasting value. The once forgotten alley between Ninth and Tenth streets, which connects Congress Avenue and Brazos Street in Downtown Austin, has been transformed into a collaborative space to bring attention to public urban places and foster discussion about the new possibilities for their uses
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What was important about this report is that it drew conclusions from an enormous sample size of children between 12 and 23 months of age collected from seven health organizations across the United States. That large of a sample size gives researchers greater confidence in its reliability.
The data were collected between January 2000 and October 2008 from Group Health Cooperative in Washington State, Kaiser Permanente systems in Colorado, Northern California and Oregon, Harvard Pilgrim Health Care in Massachusetts, HealthPartners in Minnesota and Marshfield Clinic in Wisconsin.
The project discovered that seizure incidence peaked during days seven through 10 after vaccination, "with the most prominent peak following MMRV." However, there was no peak in seizures for children vaccinated against just varicella. Other complications, such as the severity of the seizures or death rates, were not evaluated in this portion of the project although that may be included in a later analysis.
The MMRV vaccine was licensed in the U.S. in September 2005. It is made by ProQuad, Merck & Co. Inc. "At the time of its licensure, use of MMRV vaccine was preferred for both the first and second doses over separate injections of equivalent component vaccines (MMR vaccine and varicella vaccine), which was consistent with the CDC's Advisory Committee on Immunization Practices' 2006 general recommendations on use of combination vaccines," the MMWR said on May 7.
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PartSelect Number PS559026
Sold individually.
This part works with the following brands: Whirlpool, Admiral, Estate, Inglis, Kenmore, KitchenAid, Roper, Maytag, Crosley, Jenn-Air, Hardwick, Magic Chef, Amana, Caloric & Glenwood.
This part fixes the following symptoms:
This is a 1500 watt surface element.
With this element, you can adjust the size of the burner you want to use to match your pots/pans.
Level of DifficultyReally Easy
Time to do repair:Less than 15 mins
ToolsScrew drivers
CustomerShaveta from Sterling, VA
The sketches on PartSelect.com were very-very helpful, in picking up the parts to order and also while fixing the parts.For oven range. First I removed the two screws that hold the flat top in place and lifted the flat top. I then unscrewed the two screws that holds the element kit. Disconnected the three wires, and replaced the broken element with the new one. All done.For dishwasher, just snapped the parts in and all set.
Help other customers find the most helpful instructions.
Were these instructions helpful?
Level of DifficultyA Bit Difficult
Time to do repair:15 - 30 mins
CustomerLonnie from Ashton, ID
First of all, I shut off the electricity to the stove. I had to remove the two screws holding the stovetop in place. I then lifted it up and braced it to keep it from falling, removed the bad element, carefully marking the 4 wires that were connected to the element. I then disconnected the wires, and removed the two brackets holding the element in place. I replaced it with the new element, reconnected the wires, returned the stovetop to it's original place, put the two stovetop screws in, and turned on the electricity. Then I turned on the element, and it works just fine.
Time to do repair:30 - 60 mins
ToolsPliers, Screw drivers
CustomerMorgan from College Station, TX
pulled oven out in the open, unplugged from outlet, removed two white front side panels, removed four screws on sides, unplugged range from harness, removed top, unscrewed two metal clips that hold element in place, gently removed wires from element using a small screwdriver and needle nose pliers and attached each one to the new element as it was removed. Reinstalled as I took apart. For the range hood, I unplugged the hood, removed the covers to the switch box and used a small screw driver to open/destroy the old switch and to save the tinned wires. I then pushed in the wires into the new switch as I removed them from the old one. Should be careful to only snug up the hex nuts as the plastic switch stem will probably break easily with a little force.
CustomerPAUL from SCOTTSDALE, AZ
Removed two screws bottom front corners of range top - propped the top up - removed the wires from the element - removed the old element - installed the new element reattached the wiring reattached the hold down screws and bingo it worked!First thing to do is turn the 220volt electrical circuit breaker to the unit off and the last thing is to turn the breaker back on!
CustomerWilliam from San Diego, CA
First , I turned off the circuit breaker to the oven.Next, I removed the two screws at the front of the range top and slid the top out until I could disconnect the multi-plug connecting the wiring harness to the stove.I then took the entire top out to a table and set it upside down. It was easy to unbolt and disconnect the lead to the element. One of the leads was burnt, so I had to replace it. I slid the new element into place, bolted it down in the same orientation as the old one and reconnected the leads.I slid the entire top back into place on the range and re-installed the securing screws. Then I flipped on the circuit breaker and turned the element on.Success! Perhaps I didn't really need to change the element since the burnt lead was the cause of failure. But its good to have a new part installed anyway.
All brand logos are trademarks of their respective owners.
The PartSelect logo is a Registered Trademark of Atlantic Laundry Centres, Ltd.
Copyright © 1999-2016 , Eldis Group Partnership. All rights reserved.


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Can you do pedicures on people with psoriasis on their legs? What precautions should be taken?
I would avoid the use of water or soaks with a psoriatic patient. Gentle nail care including polish can be attempted if the client is not hyperreactive (sensitive) to the polish. A dry pedicure would be safe. Any trauma to psoriatic skin will hurt the sufferer, so avoid scrubbing, soaks, etc., on affected areas. As long as the nails are free of psoriasis, it's safe to treat the them. If not, it's best if the client gets clearance from her doctor. — Johanna Youner, D.P.M., is attending podiatric physician and surgeon at New York Downtown Hospital and is also in private practice in New York City.
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Phish covered the whole "Exile" album front to back on 10.31.09 - check it out, it was incredible - and it can be done!
I think this is a great idea!
Mick Jagger looks wonderful
well I hope the Rolling Stones tour again
they have lots of songs from many albums
Exile is my favorite Stones album. It is phenominal. You can hear many distinct musical styles. Who does that any more?
I am a huge Stones fan. Exile is an acquired taste. It explores almost every type of classic rock, and many of the songs are really well written, althogh not hooky in a pop sense. I am not sure it would work on a stadium or arena tour. Can you imagine what scalpers would get for tickets on a club tour!
I would pay 5 grand to see an Exile tour in a 2000 or less capacity venue
It would certainly be interesting but as Mick says, not a real draw for all those who are wanting to hear Stones Standards.
I would really like to see Mick Taylor and some other performers come on stage to perform with the Stones. Hmmm ... Eddie Vetter harmonizing with Mick and Keith on Sweet Black Angel? Willie Nelson singing along and picking on Sweet Virginia?
Just some thoughts.
I saw the Stones perform Exile on tour in '72 in Charlotte, NC. Stevie Wonder opened. Of course the most lyrical and accomplished Stones guitarist, Mick Taylor was still in the band. Given what I've seen of Stones live shows of late (all on video or movie) they are a pale imitation of what they were in '72. Even when they play songs from Exile they are hurried as with all their "hits" like they are playing at 1.25 speed instead of 1.0. Also Ronnnie Wood tries hard but is simply way overmatched by Taylor on guitar.
As to Exile, it is simply the best of the Stones albums and along with London Calling is the best album made to date in the rock genre. It is art as much as the 9th is.
Glad to see this classic record getting another day in the sun (think I could still score a $40 ounce?)....I hope that Mick Taylor is picking up some well earned royalties from this reissue...even Wyman and Watts agree that he was the best pure musician to ever play in the band....It is too bad that this classic line-up only lasted for 5 years (their most creative)...they certainly could have used his creativity and talents over the last 30 (uneven) years....Still without a doubt the greatest rock band ever!...Can't wait for Keith's autobio in November.
When Mick stops blazing new trails he will cease to become interesting. He's in danger of becoming a nostalgia artist, something he's said he wanted to avoid at all costs. I would like to see Mick Taylor return to the Stones, if only for just recording, and a return by Mick to writing great lyrics. One can't expect Mick to jump like he did in the 81 tour, but he's still capable of writing and performing great blues tunes, much like Bob Dylan.
Just do a secret show at the Whiskey in Hollywood, say your a Rolling Stones Cover band. Just give me an email when you book it, I dont want to miss it!
PMS is their best new release imo. It can stand the Exile test.
Saw the Stones in '73,amazing.
Saw them again in '76,and left after the Wood's first guitar solo. .The right guy in the wrong place.
After Bl&Bl I lost my interest in them. Love the Jones/Taylor period.
anybody who followed the stones from their beginning knows what Mick Taylor meant to the sound of the band. mostly their post-taylor music seems empty; it simply lacks an entire dimension - taylor's fluid, blues-rock solos. fortunately for the glimmer twins, because of the powerful music of the taylor-era the stones endured and prospered. unfortunately for mick taylor, he has not. and the royalties he deserved for his contributions stopped in 1982. until he gets paid, i suggest if you want to buy a stones album at least buy one of mick's, too. you just might hear what's missing from "the greatest rock n roll band in the world".
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My name is Jacqui. I am 24 years old. I live in Melbourne, Australia.
I love music and I love travel, and my favourite thing in the world is to combine these 2 loves together. So far I have been lucky enough to attend music festivals and gigs in Japan, London and the USA, and I hope to continue this hobby of mine and see the rest of the world.


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Fantasy Classics : Graphic Classics (Paperback)
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"Romance, wizardry, dreamworlds & Mary Shelley''s Frankenstein!"--Cover.
|Diamond Comic Distributors
|Mfg Part#
|Release Date
|(in Inches) 9.75H x 7L x 0.5T
Author Info
|Mary Shelley
|The daughter of feminist and radical Mary Wollstonecraft and political philosopher William Godwin, Mary Shelley eloped with Percy Bysshe Shelley when she was only 16. The two traveled across Europe, and Mary eventually wrote a travel book about their flight. They married two years later, after Shelley's first wife drowned herself. Mary Shelley began FRANKENSTEIN in 1816 as part of a contest suggested by Lord Byron when the Shelleys were visiting him in Italy, and turned it into a full-length novel with the encouragement of her husband. Despite the social and artistic stimulation of a close circle of friends, and Shelley's success as a poet, the Shelleys' lives were not free from pain: in the space of two and a half years, they produced four children, losing three of them in infancy, and by the time Mary was 24, she was also a widow: Shelley drowned in the Gulf of Spezia while out sailing. Forced to support her one remaining child, Percy, Jr., until he inherited his grandfather's baronetcy and estate in 1844, Mary Shelley turned to writing novels, reviews, and travel articles; her last book, RAMBLINGS IN GERMANY AND ITALY, was a a two-volume account of a trip she took with her son and some of his Cambridge friends. FRANKENSTEIN, her novel of the "Modern Prometheus", eventually achieved a measure of fame and became a bestseller; by 1825, there were six different stage adaptations. In the years since, it has been endlessly transformed and increasingly debased by its many movie versions. Mary Shelley died, probably of a brain tumor, at the age of 53. It was often said that she was famous for her parents, her husband, and her monster.
From the Publisher
|Editors Note
|Fantasy Classics presents Mary Shelley's "Frankenstein," adapted by Rod Lott and Skot Olsen, with a prologue illustrated by Mark A. Nelson. Plus H.P. Lovecraft's epic fantasy "The Dream Quest of Unknown Kadath," by Ben Avery and Leong Wan Kok, and "Oz" author L. Frank Baum's "The Glass Dog," by Antonella Caputo and Brad Teare. Also Nathaniel Hawthorne's "Rappaccini's Daughter," adapted by Lance Tooks, and "After the Fire," a poem by Fantasy Master Lord Dunsany, illustrated by Rachel Masilamani. With a dramatic cover painting by Skot Olsen.
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