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|9th Jan 2014, 10:03 AM
Tamal Anwar
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Let me get to the point straight! I want to make a six figure yearly income..
Then 6 figure monthly income...
Please share some of your thoughts on how one can do that by staying at home. I want to hear it from those who are in that level, or nearly there.
I am not requesting you to share the whole thing or the exact blueprint; just give me some of your best tips you would give to your little brother, I can then research, apply and improvise.
About my current online status: In 6 years in IM, my peak was making a low 4 figure a month income with design services, affiliate marketing & ad sells, I just want to take this to the next level.
Update: 01-10-2014 GMT +6. The time now is 12:59 PM
Hey warriors, thanks a lot for all of your tips and insightful advices; I will take my time and try to reply to each of you individually with my thoughts.
A lot of suggestions have come up and I will be using them to my best. How the big earners make their big money? Do they earn it from one source or a combination of sources? What I have in my mind is to build multiple avenues of income (Services, Adsense, Affiliate Sells, Membership Sites) I don't think I should put all my horses into ONE METHOD -earn a killer living and then something happens and it goes away.
I say this because I have spoken to many who were earning a killing online, from one method and it went away and they are back to nothing again.
Tamal Anwar
Last edited on 10th Jan 2014 at 01:07 AM. Reason: Posting an update for the replies.
|9th Jan 2014, 10:10 AM
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Hi Tamal,
Let me be the first to commend you on your ambition. Truly: the first step to making $10K a month is always wanting and knowing you can make it.
There are literally thousands of methods available to you. And I struggle to suggest any one of them, because I don't know enough about your skills, experience, and passions.
As some general advice, therefore, I would do the following:
- Find an unsaturated niche with plenty of demand;
- Create a landing page to grow a newsletter ("The List");
- Disseminate helpful information to your readers that relates to the product
- Grow your list with the usual traffic methods
A general approach, granted, but it's a solid one and, without knowing more about you, it's probably the most suitable one to recommend.
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|9th Jan 2014, 10:39 AM
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My advice would be to decide what services you can offer to businesses and build up an authority site and start getting known in that particular area. Don't hide behind the computer screen - make phone calls daily, cold calling, Skype, approach people in real life, go to events and network.
The more you put your face and your name out there, and show others that you can add value to their business, the more success you'll have, IMHO.
All the best.
|9th Jan 2014, 10:51 AM
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Hi Tamal!
The key to getting to six-figures is to stay laser-focused on the key activities that grow your business. Every successful business is centered around the 3 CORE Activities...
Your entire day should be focused around these 3 tasks.
Sending traffic directly to a squeeze page where you can grow your subscriber list.
Many people make the mistake of NOT building a list. And because of that, they continue
to struggle. Because there is no platform, no audience, no fans.
So the first key is to build your TRIBE - your subscriber list.
But building a raving fan is much harder than simply acquiring a subscriber.
Once you have a new subscriber, you must then work hard to earn a spot in their inbox.
You do this by creating fun, personality-driven, value packed emails.
From there you can start sending them to related offers. (Your own product or an affiliate).
You can promote a product or service in almost all of your emails. The key is to
combine storytelling and value with a related product recommendation.
(This combination has worked REALLY well for us.)
In terms of traffic, I highly recommend Facebook ads right now. They are by far one of the fastest and most affordable ways to grow your subscriber list.
We're currently generating leads for 60 cents per subscriber. We've added 700 new subscribers to our list since the beginning of the year. (So in about 8 days)
And those leads have already generated 6 sales with just a few follow-up emails.
So as you can imagine - I'm super excited to see what happens over the next 30 days as we continue to nurture the relationship and provide massive value.
Next comes the offer. This part is critical. Especially if you're wanting to scale to six figures.
Selling your own products is generally the most profitable. Plus - when you have a high-converting offer you can then recruit affiliates and create a perpetual lead generator / traffic source.
I wish I had more time to go into the 'copywriting' side of things. But what's worked best for us are sales videos. Literally just a video on a page. Then include your squeeze page as the exit pop so that you can collect subscribers. (This is especially important if you're getting any amount of affiliate traffic)
But successful businesses are built by those who stay ULTRA focused on these key activities.
Get really good at ONE traffic source. I recommend Facebook Ads right now.
You then send them directly to your squeeze page, build a subscriber list, and send at least 3 emails a week.
Avoid all shiny objects and focus relentlessly on building your tribe.
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|9th Jan 2014, 11:09 AM
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My advice would be to work with products that can bank you HIGH commissions.
You want to work with products that can also pay you from the efforts of others.
I have been online now for 11 years and can tell you from my own experience that it is easier to make MORE money with products that sell for $100-$1000+ rather then focusing on products that bank you anywhere between $10-$50.
You also want to work with products that pay you residual income.
In the above post, you have a lot of GOLDEN NUGGETS advice that you should focus on.
|9th Jan 2014, 11:56 AM
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My answer is pretty much in line with Kim's. Classic marketing still works.
|9th Jan 2014, 12:09 PM
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Yes I echo exactly what Kim is saying above, but I would also throw YouTube into the equation for traffic and also building a relationship with your subscribers. Good luck
|9th Jan 2014, 02:31 PM
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|9th Jan 2014, 02:41 PM
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Raise some good advertising funds, and advertise on relative sites in your niche.... advertise alot - almost everywhere in your niche - and monitor costs vs. profits.
|9th Jan 2014, 03:21 PM
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When I see questions like the start of this thread I think, instead of asking "How can I get compensated X" I think a better question to ask is "How can I provide $X worth of value per month to people?" Its a simple shift but by focusing more on adding value than what you can make.. you might exceed your target. But by focusing only on what you can earn, you'll probably get caught up in a get rich quick scheme or something.
- James Rick
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|9th Jan 2014, 03:27 PM
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If you want to move into a higher income level then you're going to need to move into a higher level of business in general. You'll have to forget about simple things such as promoting one or two products, offering a direct work for money service, and anything else which can't be expanded enough to meet your goal.
You're going to need something bigger, something better. You're going to need a real business.
The problem most people have with that is it takes time to set up. It's hard to make a living while building a business. You might make some money but you won't see the type of figures you want until everything is established.
It's worth it, though, because this business will be more secure and longer lasting than anything you've done up to this point.
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|9th Jan 2014, 03:44 PM
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I think the biggest thing I learned for wealth creation is "leverage" .. multiplying your time through things like technology, hiring staff and investing in ways that generate a high return on investment.
Unless you are a super talented athlete, movie star , etc. trading your personal time for money is one of the hardest ways to actually earn good money.
Its far easier to trade the time of TWENTY people for $10k a month than it is to trade the time of ONE person for $10 k a month. So if you can earn $500 a month on TWENTY people you earn $10 k a month. That's the concept.
- James Rick
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|9th Jan 2014, 04:27 PM
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There have been many great points posted on this thread.
I just wanted to add a few pieces that I believe are trivial:
1. A SYSTEM - because you should be focusing on driving traffic it is best to have a system that will convert that traffic for you.... it means you have less to focus on. It is much more efficient to become an affiliate to a company that already has a broad product range (currently my team offers starting at $25 up to $3,000. in commissions) than to first develop products and THEN start taking the action.
2. A MENTOR - work with someone who has DONE IT BEFORE YOU OR is currently working DIRECTLY with people who have what you WANT.
3. THE MINDSET - in order to achieve you first must believe - I am sure I am not the first to share that tidbit with you!
4. LEVERAGE - your time and your money. When possible outsource the tasks you are NOT into. Use other peoples strengths to compensate for your weaknesses, rather than struggling to do it ALL.
5. SCALABILITY - You can start using FREE marketing (facebook, video, other social media, blogging, seo, etc.) As you are generating revenue invest in marketing you can SCALE UP as your revenues increases. Rather than having to develop multiple marketing skill sets stick to one paid strategy, master it and as your revenue increase - your marketing budget will increase - and your profit will increase.
I trust you find value in these 5 tips to getting to the 10K level.
To Your Success,
Meghan Swim
|9th Jan 2014, 04:43 PM
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provide value. scale. make tons of money. simple
|9th Jan 2014, 05:38 PM
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I started a web design and consulting service and i make around 20 to 30k a month but it is a very long process if you don't have the right information.
To be honest I make most of my money for CPA and affiliate sales
|9th Jan 2014, 06:28 PM
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Learn paid ads, scale on target audience... you can do that with cpa or wso offers, but you have to educate yourself so will be some money lost on the way. Then it'll be fast and easy money
|9th Jan 2014, 07:32 PM
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|10th Jan 2014, 01:13 AM
Tamal Anwar
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|10th Jan 2014, 04:51 AM
Tamal Anwar
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I could search the WSO and grab on any millionaire scheme but I don't want to do that, because I want to build my own plan, that fits in my situation.
On providing value: Then I do believe I am providing 2x-3x value to my clients and readers at the moment than what I am getting paid for. The problem with value is, it's different from person to person. Something that has X amount of value to me, could have Y amount of value to you. So I can't just write "Hey, how do I provide $10K value to my clients" because if someone has backpain, then the cure could be valued $10K to them and for those who are fine, they will see it as just another $47 ebook.
|14th Jan 2014, 09:50 PM
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I'll keep it short and simple. The kind of income at the exponential growth levels you are referring to are characteristics of a successful product. There really is no way to get to that level of exponential growth in a short period of time in a service based business. So if you have started creating your first product by now, you are on the right track.
|14th Jan 2014, 11:35 PM
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You're very smart not to put all your eggs in one basket...multi stream is the only way to go and put as much automation in place as possible. All the best to you!
|15th Jan 2014, 12:19 AM
Tamal Anwar
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|15th Jan 2014, 12:27 AM
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1. LASER FOCUS - while coaching I often see people who try to diversify too fast. They think that they need to do the same as Richard Branson or Donald Trump and they try to run several businesses at once without getting even 4 figures from any of them. For most people is making no money and just spending money on joining fees.
2. MASTER TRAFFIC GENERATION - again you need focus. Most people who start in IM field they are overwhelmed by the number of options available to generate traffic and they think they need to do everything. But the truth is, pretty much every superproducer uses 1-2 strategies and they master them. Go into depth instead of width. It is a pealing onion job.
3. IDENTIFY MMAs and outsource the rest. MMA - is Money Making Activities, i.e. time spend in front of potential customers (or customers - upselling).
4. PIPELINE YOUR TIME - HVA - create a pipline of your time to be focused on HVA - high value activities - 85% of your time. 15% of the time spend on necessities. Most people do it the other way around.
5. WORK WITH A MENTOR - that is the biggest shortcut ever if you pick the right person.
Good luck and make 2014 a magical year!
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|15th Jan 2014, 01:13 AM
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as we know , so many online businesses and internet marketing are scattered in cyberspace . So many Roads and Ways to earn money on the internet , I can not write them all down one by one . But I think the most common and frequent and easy to work with as I list below :
1 . PPC ( Paid per click ) Largest : Google Adsense
2 . Other PPC : Chitika.com , Clicksor.com , Adhitz.com , Bidvertiser.com , et al ..
3 . PPC image : Luminate.com , Imagespacemedia.com , et al ..
4 . Local PPC : Kliksaya.com , Kumpulblogger.com , Adsensecamp.com , IdBlognetwork.com , Innity.com , Sitti.co.id , et al ...
5 . Affiliate Marketing : Amazon.com , Ebay.com , Clickbank.com , Commission Junction ( cj.com ) , et al ...
6 . Pay Per Impression : tribalfusion.com , casalemedia.com , smowtion.com , adreactor.com , matomymedia.com , xtendmedia.com , snap.com , paid-to - promote.net , blueadvertise.com , trafficrevenue.net , BurstMedia . com , globaltakeoff.com , et al ...
7 . Pay Per Action / CPA Program : CPALead.com , Maxbounty.com , Adscendmedia.com , Azoogle.com , filinet.com , fluxads.com , revenueads.com , adjal.com , adscendmedia.com , affiliatebot.com , cj.com ( commission junction ) , clixgalore.com , CPAboo.com , CPAbullet.com , CPAeMarket.com , Globaldirectmedia.com , lidango.com , linkshare.com , nichepreform.com , peerfly.com , perfecttracking.com , profitistic.co.uk , reachresult.com , synervation.net , triadmedia.com , vcommission.com , et al ...
8 . Text Link Ads : infolinks.com , kontera.com , teliad.com , et al ...
9 . Sale Services :
Can in large forums such as : kaskus.us , adsense - id.com , digitalpoint.com , warriorforum.com , et al ...
For Sale Services in Fiverr.com , microworkers.com , elance.com , etc ...
The services that can be sold include:
Service Writer / Author Article :
Blog Update Services
Complete SEO Services
Link Building Services
Services Make a Website
Making Services Logo and Header
Services Like and Twitter Follower fanspage
Make services a wide variety of accounts , both account Adsense , Email Accounts , Ping.fm Account , Account forums , Paypal Account , and all kinds of accounts .
Verify Paypal Account services ( buying and selling VCC ) and Paypal Limited Release ( makes skrinsut requested Paypal )
U.S. Bank's services to create an account
Submit articles and Website services to Social Bookmark , Article Directory , etc ...
Moving Services Hosting
Rental Services Hosting and Domains
Services Survey
Other services that I can not mention one by one so many . Whatever your ability , Everything can be sold in the form of services ..
we can use the Internet to stay it becomes a source of money for us .
if we are serious about even more than $ 10K a month can we possibly even more targets ..
|15th Jan 2014, 01:47 AM
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Begin selling leads to businesses. You need to start setting up passive income streams. Having my own lesson in this right now. It will not happen unless you learn to be residual and passive in your thinking. This can also be done in IM arena in the form of membershp sites, I don't care which one you might be thinking of but also get your mind to focus on as EASY as possible.
I appreciated Kims comments as well she is right about the list too.
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|1st Mar 2014, 02:42 AM
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start with CPA. build list . create membership sites.
|1st Mar 2014, 04:06 AM
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Probably building an authority site would be the way to go.
|1st Mar 2014, 04:37 AM
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Have you made $100.00 a month? $1000.00 a month?
Everyone wants to start out and make the "big money" and that is a great goal but you have to start out somewhere like the rest of us did, making smaller amounts. Once you learn how to do that then just do it over and over.
Stay focused on one thing, don't jump around from niche to niche. Become an "expert" in your field. The internet is just a vehicle for you to use, not your whole business. What I mean by that is there are so many ways to work to achieve your goals including other avenues to use. It took me a long time to realize that because I wanted to be a guru like the big guys. Then I found out the "big guys" used more than the internet too.
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Can anyone explain the differences between the Sugino 75, Sugino Messenger, and Sugino KyotoLoco cranksets? I've become fairly confused by all of it (especially after looking through the Sugino website).
Can anyone explain the differences between the Sugino 75, Sugino Messenger, and Sugino KyotoLoco cranksets? I've become fairly confused by all of it (especially after looking through the Sugino website).
sugino 75 are niiiiice
dj: 09 eastern night train 26
fg: volume cutter 2nd gen w/ spicer track fork
bmx: fit dak build
sal about en jay es
NJS is only worth it if u actually ride on the 'drome
dj: 09 eastern night train 26
fg: volume cutter 2nd gen w/ spicer track fork
bmx: fit dak build
Sugino Messenger is your basic road crank, but accepting only one chainring. (It's just like the RD crankset, but with a different ring.)
Sugino 75 is a track crank, being much stiffer along all axes than the Messenger, and nearly three times as expensive. (The Grand Mighty is a version of the 75 that is forged many more times over, compared to the base 75, making it even stronger. It, and the 7600 Dura Ace, are the preferred cranks of the Japanese Keirin riders.) For what it's worth, the 75's can bear the NJS stamp of approval.
KyotoLoco is a version of the Messenger crankset that Sugino made to commemorate a big messenger jamboree in Japan. It comes in many attractive colors.
or if you need a big internet penis
NJS is worth it because its a stamp of quality. By buying NJS you know you are getting a quality part, just like people buy cars from reputable manufacturers and computers with good warranties. Sugino 75's arent any more expensive than a nice set of cranks that arent NJS, they are good cranks at a price they should be.
what exactly are the sugino comp's on '08 langsters? i can't find them on the sugino website or google.
75s are machined instead of forged?
where would you get that idea? i cant imagine any crank still being made today that isn't forged..
it's possible i don't know what i'm talking about?
just read this. didn't know what i was talking about.
i thought "machined" because the insides of 75s are so smooth and the others have rougher splines on the back of the spider.
It means nothing in regards to performance and thanks to the cost of achieving the stamp of approval and the unexpected recent marketing power of that little mark, the cost is invariably higher.
You can buy Sugino 75's with and without the little stamp. They are the exact same cranks save for the stamp, but one is usually around twenty dollars cheaper.
To wit, do guys who really like NASCAR insist that their cars conform to the NASCAR Aerodynamic Chassis Template?
My commuter has RD cranks on them and they are perfectly fine, but one session on the track revealed how flexible they really were when sprinting. 75's are much stronger than I am, so they are perfect for on-track exploits but they would be just overkill on a street bike.
RD's for the street
75's for the track
unless you've got money to burn.
yes, RD's for the win.
in Japan the ones WITH the NJS stamp are a lot cheaper. the NJS'ers are silver, the non-NJS (well, rubbed out NJS mark) are the anodized ones in all the pretty colors that fashion demands. and they are about $50-80 more expensive.
Sorry to revive a dead thread.
I have those ****ty FSA vero track cranks on my bike right now, and they have deveoloped play becuase the spider bends from skidding.
Will the RD be a strong eneough crank to be ridden on the street?
my toe clips are enjayess.
once you go tarck, you never go barck
i have a set of black suginos. on the inside of the spider it says RD2H TL and on the arm it says 165 Y G-11 forged.
what cranks do i have?
bikethrow. #thelanternrouge #MFDCR


text:
My little bird by ZennoreWatch
©2012-2016 Zennore
Another story I drew for work. But it might not be used, since the story doesn't have much of a concept or a meaning.
so cute
Is it a reference to twitter? If it's not might I suggest changing the color of the bird. Unfortunatly I think that all little blue bird will forever be associated with twitter.
Well the true story behind this was that I was planning to have some special friend for the woman at the end. An animal was what I had in mind. But the common dogs and cats have been used in the first and second scene. So the next common pets would might be birds and/or fish. I was trying to go for a more magical feeling for the last scene, but after redrawing it over and over again, I gave up, and just added a Twitter bird. And gave the story another meaning besides just "special friend". So in a way, that Twitter bird was added on purpose.
i was gonna say twitter too but i saw the comments
....so im hacking them to be the first one who thought about it cook
....so im hacking them to be the first one who thought about it cook
It reminds me everytime I see my bird ^^
Aww, that's so cute. ^^ (Took me a while to figure out what that droopy-eared dog was though, I was thinking it was supposed to be a cat and... a cat with a shape like that?)
I like it! It's simple and cute, but it still seems symbolic and deep.
I like it! It's simple and cute, but it still seems symbolic and deep.
O.O omg I was totally thinking Twitter too and I didn't know why.


text:
Solar Physics
Calluses to Klingons
12 Years On Mars
This Just In
Gravity waves, gravitational waves and primordial gravitational waves... what do they mean? Is there a difference?
More gravitational wave discovery rumors are flying, but this time they've taken a specific -- and, possibly, really exciting -- new twist.
Although he's almost 250 miles above the ground, NASA Astronaut Scott Kelly still managed to capture a fleeting glimpse of yesterday's Super Bowl matchup.
If proven, it would be the first such death in recorded history.
In November 2014, the plucky lander Philae touched down on a comet, making headlines worldwide. A hard landing drastically shortened its lifespan, but scientists still gleaned a ton of new information about comets.
US astronaut Edgar Mitchell, one of just 12 people to have walked on the moon, has died.
A NASA spacecraft now has Jupiter more squarely in its sights ahead of its July 4 arrival at the solar system's largest planet.
An asteroid as long as a basketball court will give Earth a close shave next month.
+ Load More


text:
writing a temp matrix to disk
hi there…
i have a patch that loads in a text-based matrix data file and temporarily writes it to disk (for archiving) via jit.matrix, then loads that jxf from the specified location.
i am loading it while i also have a JSUI that is pegging the CPU at low priority, quite nastily.
the problem i am experiencing is that if the JSUI is open (and sludging along), the jit.matrix can't seem to write the data file. i have no idea why this would be happening though.
i get the message:
jit.matrix: could not create file my/example/path/myfile.jxf
the path is correctly formatted and if i try the identical operation without the JSUI involved, it works fine.
i hate to issue questions like this with a preface that the patch is giant and not worth posting, but this seems to be the case. there are simply too many things going on and i know that the write operation should work… i've just never seen this behavior.
would anyone have any thoughts on what could be happening there?
thank you,
here is an example of the file writing mechanism, just in case it helps:
----------begin_max5_patcher---------- 810.3ocyX1saiBCDE9ZxSgER8trQLl+Bq1K59brpph.lT2ELHvQMsU8ceM1j 1jtIfSJwkabJSrqO9aFeLNuNyxdU4VRiM5mn+frrdclkkLTa.qtmsrKh2ljG 2H6lcRYQAgwsmq9NNYKWF+WHXApohjPydFUEyeXWOD+cxCT156qIIb0L44sv YNBursE7cjeHd.cW2PXaJnrbBWNiPWvrRFmEWPjy1uqow41ez8xM7c82YW+q WuRMcxI3iFXuYpplzHVMwbZIaOA55G11ynCF46CpUIMzWjJAZ+VUXZpTZkqd 7GPfcar2lMqsY9WFs3En7x3TTFMmHYvPrMv46msZfI+KASq1v4krdP.14CDf euseBb35bWTUH9yUD0+Y6Uwr01CU8.NxJa2iV7r+xGtjkOi7jXv+WQRYEgkJ RbkqGjLQ31V+nws1.eJlYOWWtARg4Edo65buhkSXuqd4zdKE2qRkAJqLOsmU JnpL.e4GgK+1JPzHWOh.hiVgZ5AK9AxsyApc0t5UA7kohjHBxbBpfOFUBGUp rlHWAB5zOe51TrTtCAzcKht.xavxl4WFrfwjVMU0TFOC8TMkSP2zbiFETpip Amn9AF9LA1IcaNK3fGQ3rgUEm7WTiFUQfqxBxMzPayN2pFeCZ7zgD0axLoMd BFQp7RNplL7aw.KUmOAAi61mQqRwywjPoySQwFOmIJShtBVt0DwMiFvws6PI UsB3DNAcb8FQz7HkunHlWS2htMNMthifAgiWmyK.FxmQHx6Uh7r2YAiLqxjk RnakmdWTlRP.51VohxD26l6h66klcT1ygc9PKm936faWHGncNk84eGH4ZsM9 gLsobScxNQzcsKwM0de9SIMbJSd2t85j+A84AZZJgs+unPAMspTjC5z.5til f0VRZnnHQefIkhDGXXRIoSZCNuzFNZg+bjOz1hcfcO7UYmNv6SUgW87YnX5b GJgZVM4oClBMOlvSKL8IDbBMAlM04NA0jiNZxnRJ3.CxSqHyYh5qghD2k1jR JRGa.rwyaZc5miQSbCIo.y5Kg0PRl09dB5TFpiE.X9CT.MdcyKURhGda1+.8 25b0 -----------end_max5_patcher-----------
Forums > Jitter


text:
In a down day for the broader market, utility stocks dominate the S&P's top movers and Dow Jones Utilities are up 0.5%. With investors unable to find much yield anywhere else, the healthy yields on utilities are proving difficult to resist: EXC +1.8%, PPL +1.7%, ETR +1.2%, DUK +1.1%, NU +1%, AEP +0.8%, DTE +0.6%, WEC +0.8%, POM +0.8%, PCG +0.6%.
In a down day for the broader market, utility stocks dominate the S&P's top movers and Dow...
From other sites
Video at CNBC.com (Sep 2, 2015)
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at CNBC.com (May 22, 2015)
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ETF Hub
ETF Screener: Search and filter by asset class, strategy, theme, performance, yield, and much more
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text:
Your Shopping Cart is empty.
Give it purpose - fill it with water filters, air filters, refrigerator filters, and more.
This two pack of Culligan P1 Sediment Filters will allow you to filter out sediment from your drinking water. These Culligan sediment filters are used in the Culligan HF-150, Culligan HF-160, Culligan HF-360 and any Pentek filter housing that accomodates standard size 10" water filters.
Culligan classifies the P1 water filter as a Level 4 filtration product, meaning it offers premium filtration of very fine sediment particles. Specifically, the Culligan P1 filter removes sediment, rust, silt, scale, dirt and sand.
Culligan P1 Filter Specifications:
This two pack of Culligan 10" sediment filters is also known as the Culligan P1-D (D is for double pack). The Pentek P1 is a compatible water filter, whereas this is a genuine Culligan water filter. Culligan has been a trusted water filtration brand since 1936.
Get Culligan water treatment without calling the Culligan man!
|P1-D is used in the following Models
Culligan HF-150
Culligan HF-160
Culligan HF-360


text:
Top Definition
a phrase invented by a man living in Whittier California that refers to opportunity seen by an individual to change a song into a ska cover.
As I listen to this song, I envision a ska-pportunity.
by AngelMalo07 June 28, 2009
Type your email address below to get our free Urban Word of the Day every morning!
Emails are sent from email@example.com. We'll never spam you.×


text:
10 Best Hair Resolutions for 2015 view
Queen Bey's Best Hair Moments view
Perfect Your Ponytail view
Corinne Bailey Rae arrived at the Elle Style Awards wearing a high halo of lush,...
Corinne Bailey Rae arrived at the Elle Style Awards wearing a high halo of lush, shiny curls. You can rock Corinne's look by sectioning off your bang area and pulling the remaining hair into a loose bun. Take the front section and use a wide tooth comb to add volume at the roots. Pin the hair back into the bun for an easy, glamorous look.
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text:
Leonardo Boutique Hotel Sagrada Familia
u Show map
7.9 / 10
This is what awaits you:
Free WI-FI
Hotel's own parking spaces
Reception open day and night
Hotel description Leonardo Boutique Hotel Sagrada Familia
The Leonardo Boutique Hotel Sagrada Familia is a hotel in Barcelona near Sagrada Familia, just 10 minutes walking away.
It has a total of 59 comfortable guestrooms (Standard, family and 2 junior suites). All of them are exterior and offer: LCD flat screen, wireless Internet access, safebox, air conditioning and heating, telephone and working desk. Leonardo Boutique Hotel Sagrada Familia is equipped with light bulbs "LED" low energy a way to raise awareness of the environment.
Further information on the hotel
The Leonardo Boutique Hotel Barcelona Sagrada Familia (Former Acta Ink 606) offers customers all the services and amenities necessary to enjoy your stay in Barcelona. It has wi-fi, business center, TV room, Internet room,reading room, 24 hour reception. The Tourist Tax will be paid directly in the hotel. Our rooms adapted for handicapped people has a maximum capacity of 2 people.
Reception hours
Every day 24 hours
Check-in time:14:00
Check-out time:12:00
Like this hotel?
Then save it in your bookmarks.
u Show map
Carrer de Mallorca 606, 08026 Barcelona, Spain
Distances (km)
|Metro / suburban train
|City district (Barcelona)
|Station (Barcelona - Passeig de Gràcia Railway Station)
|Station (Clot)
|Airport (Barcelona International Airport (BCN))
|Airport (Girona Airport (GRO))
|Airport (Reus Air Base (REU))
To reach the hotel
Starting point:Urban Bus 33, 34,35,43 ,44,b20 ( Santa coloma- Ronda sant pere), N9 ( Bus nocturno- Tiana/plaza Cataluña) Clot aragó ( L2, L1, R1 rodalies Renfe) FROM THE NORTH: Log in Barcelona North /... more
For HOTEL INFO guests
Free WI-FI
Hotel features
- Double rooms: 59
- Hotel's own parking spaces
- Lift
- TV room
- Reading room
- Business Centre
- Soft-drink machine
- Air conditioning in public places
- Safe at reception
- Barrier-free
- Reception open day and night
Room features
- Shower
- Noise-protected windows
- Window that can be opened
- Non-smoking room
- Safe
- Bathtub
- Hairdryer
Accepted credit card payments
- AmericanExpress
- MasterCard
- Visa
Hotel location
|City district
|2.8 km/1.7 mi
|15.5 km/9.6 mi
|no details
|2.78 km/1.7 mi


text:
The night is coming by Fra-EmerWatch
©2012-2016 Fra-Emer
Great colour transition.
magical shot!
This is so beautiful! Keep up the amazing work!
Beautiful love it favoriting!
E' stupendo! Come non farselo piacere?
Beautiful. Love it
wow...I looove it sooo much!!!! Stunning!!!!!
wow im loving this!!
Really nice i love the atmosphere of this photo
love the bokeh^^
Carinuccia! ^^
This one looks even better to me


text:
Chief EMEA Desk Editor for Economics and Politics
Jeremy's Feed
Don't invest in gold?
equities | Gold | investment | S&P 500
Bit of fun, this — and might raise some issues about returning to the Gold Standard. The S&P 500 stock index priced in gold (thanks to Reuters graphics whiz Scott Barber):


text:
More about Bordeaux Index - London's leading fine wine merchant
Established in 1997, Bordeaux Index has grown to become one of the leading global fine wine merchants with offices in London, Hong Kong, Singapore and Los Angeles, as well as a rapidly growing international customer base. Our product offering covers all the traditional wine growing regions of Europe plus selected wines from outside Europe.
During 2009 BI introduced LiveTrade, the world's first on-line trading platform for fine wine with firm bid and offer prices available 24 hours a day. This service won us the "Innovator of the Year" award, at the 2009
LiveTrade also produces an easy-to-read graph, 'The Bordeaux Index'; this is a real time index that tracks live changes in the prices of the most liquidly traded wines on the LiveTrade market making screen. Rather than pricing monthly, our technology facilitates dynamic, daily updates and will allow users to monitor the market at their convenience. It's the most transparent, accurate and simple way of gauging the market performance of Bordeaux. For the first time, investors will no longer need to base their decisions upon monthly market movements. Just as importantly, it does not require a statistics degree for interpretation. Registered users are also able to view individual price graphs for all of the wines traded on LiveTrade with data going back to 1st Jan 2008.
This service helped us to win us the "Bordeaux Specialist" award in 2010, at the International Wine Challenge.
In December 2011 Michael Spencer became Chairman of BI. Michael is the founder and CEO of ICAP plc, the world's leading inter-dealer broker, and a former Conservative Party treasurer; he is also one of the world's most passionate and knowledgeable wine collectors, with a particular love of Bordeaux and especially the wines of Pomerol. Michael brings unparalleled business acumen and a world-class contacts book to BI.
Our London offices have a private dining room and purpose built tasting room, which enables us to offer more tastings for clients, in addition to regular tastings and wine dinners at restaurants around London. For individual private hire enquiries, please contact your account manager.
Our wine school is run by Michael Schuster, acknowledged internationally as an expert wine taster, wine writer and wine teacher with over 25 years experience. His wine courses range from a widely acclaimed "Beginners Course", via "The Fine Wines of France", to a much sought after three day "Blind Tasting" event for trainee Masters of Wine, which takes place each May.
Buying and selling wine is only part of the BI package: we also offer the finest wine storage facilities in the UK. To ensure your wine is kept in perfect condition, we store our customer reserves in The Colerne Reserve, a brand new, state of the art wine storage facility operated by Octavian – the world's leading long term fine wine storage provider. Our own BI-dedicated team checks every case in and out, thus giving you the reassurance that your valuable wines are in the best possible hands. In addition each case will be logged and barcoded on receipt making every case individually traceable.
Bordeaux Index adhere to strict best practice in information technology. We have installed and maintain the strongest security measures in our power in order to protect customer information against alteration, loss or misuse. To this end, Bordeaux Index:
- Do not store any credit card information on our website
- Encrypt all personal data, such as addresses, phone numbers and passwords
- Do not give or sell customer and/or client information to third parties
Please see Bordeaux Index's up-to-date GeoSoftware SSL certificate below:


text:
Type: Bug
Status: Resolved
Priority: Minor
Resolution: Invalid
Affects Version/s: 3.0.1
Fix Version/s: None
Component/s: core/index
Fedora 12
Lucene Fields:New
When retrieving the scoreDocs from a multisearcher, the following exception is thrown:
java.lang.IndexOutOfBoundsException: Index: 52, Size: 4
at java.util.ArrayList.rangeCheck(ArrayList.java:571)
at java.util.ArrayList.get(ArrayList.java:349)
at org.apache.lucene.index.FieldInfos.fieldInfo(FieldInfos.java:285)
at org.apache.lucene.index.FieldInfos.fieldName(FieldInfos.java:274)
at org.apache.lucene.index.TermBuffer.read(TermBuffer.java:86)
at org.apache.lucene.index.SegmentTermEnum.next(SegmentTermEnum.java:131)
at org.apache.lucene.index.SegmentTermEnum.scanTo(SegmentTermEnum.java:162)
at org.apache.lucene.index.TermInfosReader.get(TermInfosReader.java:232)
at org.apache.lucene.index.TermInfosReader.get(TermInfosReader.java:179)
at org.apache.lucene.index.SegmentReader.docFreq(SegmentReader.java:911)
at org.apache.lucene.index.DirectoryReader.docFreq(DirectoryReader.java:644)
The error is caused when the fieldNumber passed to FieldInfos.fieldInfo() is greater than the size of array list containing the FieldInfo values. I am not sure what the field number represents or why it would be larger than the array list's size. The quick fix would be to validate the bounds but there may be a bigger underlying problem. The issue does appear to be directly related to
LUCENE-939. I've only been able to duplicate this in my production environment and so can't give a good test case.
- All
- Comments
- Work Log
- History
- Activity
- Transitions
This exception looks like index corruption... would be good to get to the root cause of how this happened.
Your terms dict, which records the field number and character data for each term, has somehow recorded a field number of 52 when in fact this segment appears to only have 4 fields.
Can you run CheckIndex on the index and post the result back?
Any prior exceptions when creating this index?
I don't think adding a bounds check to FieldInfos makes sense – the best we could do is throw a "FieldNumberOutOfBounds" exception.
The index is relatively old and doesn't appear to have been modified for a number of years. I can't say for certain about prior exceptions. If the CheckIndex results provides any more details, then great. Regardless, I'm willing to chalk this up to a system specific error and close the ticket. I was able to fix the index using Luke.
Yikes – you had 10 corrupted segments (of 23) and there's at least 4 different flavors of corruption across those segments! Curious... What storage device did you store the index on?
Note the that "fix" just drops those segments from the index, so any docs that were in them are lost.
I believe at the time we were storing on a NAS via NFS. If my memory serves me well, there were known issues with running Lucene over NFS at the time. We were experiencing issues with the file system at the time so have since moved to a different architecture.
Also, I was aware that the fix drops the segments, but thanks anyway.
OK I'm resolving as optimistically invalid
I have an almost identical stack trace from v3.6, but I did get the index from someone else so I don't know where they were storing it.
java.lang.IndexOutOfBoundsException: Index: 100, Size: 64 at java.util.ArrayList.rangeCheck(ArrayList.java:635) at java.util.ArrayList.get(ArrayList.java:411) at org.apache.lucene.index.FieldInfos.fieldInfo(FieldInfos.java:255) at org.apache.lucene.index.FieldInfos.fieldName(FieldInfos.java:244) at org.apache.lucene.index.TermBuffer.read(TermBuffer.java:86) at org.apache.lucene.index.SegmentTermEnum.next(SegmentTermEnum.java:133) at org.apache.lucene.index.SegmentTermEnum.scanTo(SegmentTermEnum.java:174) at org.apache.lucene.index.TermInfosReader.get(TermInfosReader.java:202) at org.apache.lucene.index.TermInfosReader.get(TermInfosReader.java:172) at org.apache.lucene.index.SegmentReader.docFreq(SegmentReader.java:539) at org.apache.lucene.search.TermQuery$TermWeight$1.add(TermQuery.java:56) at org.apache.lucene.util.ReaderUtil$Gather.run(ReaderUtil.java:81) at org.apache.lucene.util.ReaderUtil$Gather.run(ReaderUtil.java:87) at org.apache.lucene.util.ReaderUtil$Gather.run(ReaderUtil.java:70) at org.apache.lucene.search.TermQuery$TermWeight.<init>(TermQuery.java:53) at org.apache.lucene.search.TermQuery.createWeight(TermQuery.java:199) at org.apache.lucene.search.BooleanQuery$BooleanWeight.<init>(BooleanQuery.java:176) at org.apache.lucene.search.BooleanQuery.createWeight(BooleanQuery.java:354) at org.apache.lucene.search.Searcher.createNormalizedWeight(Searcher.java:168) at org.apache.lucene.search.IndexSearcher.createNormalizedWeight(IndexSearcher.java:664) at org.apache.lucene.search.IndexSearcher.search(IndexSearcher.java:364)


text:
Reviews - Garston Cottage3
28 ASHLEY ROAD Bathford, BATH, BA1 7TT
Price From £80View Rooms
Customer Reviews
Our reviews are from genuine LateRooms.com customers. We verify that the customer has stayed before leaving a review.
Very Good
93% would recommend it to a friend
Customer service
Food quality
Room quality
pleasant stay
garston cottage was a great find for visiting Bath, the owners are lovley and helpful.
the breakfast was excellent my husband really enjoyed the cooked breakfast. There is an great pub down the road and a regular bu serice which runs into Bath town centre
Read More Less
Fabulous little find
What a lovely place.
It was cosy and they were incredibly welcoming. We would highly recommend to anyone (and we have already!)
Read More Less
Garston cottage
The room had very little air circulation as the windows were tiny, no air con or fan.
a very warm room which meant we didn't get much sleep. The mattress on the double bed was very soft and lumpy....I ended up sleeping in the bottom half of the bunk bed as it was a family room. The bathroom was modern, good sized, powerful shower but shower head was dirty and some of the grouting in the shower wall was discoloured, needed cleaning better. Shower tray was clean. Sink was clean. Very generous with toiletries and tea/coffee facilities. Breakfast was excellent. Seated on one large table with everyone else made it a social event although space was cramped and felt a little uncomfortable.
Perhaps the room should be reconfigured to allow more space for dining, less lounge area ( which probably doesn't get used anyway?) I would recommend it to friends/ family and would stay there again. Very pretty village location, good pub food locally. Close to Bath.
Read More Less
Homely B&B in lovely countryside setting.
Relaxed and cheerful welcome met us at this lovely little cottage B&B just a few minutes drive outside Bath city centre.
Our visit was for an overnight stay to collect our son from University and Garston cottage was the perfect base from which to do this. Myself, my husband and 23yr old daughter shared an adequately sized room with double and single bed, which we found perfectly comfortable. The en-suite shower room was a good size too. The well stocked hot drinks tray including some lovely biscuits and Horlicks was very welcome after our long journey and the sweetie dish a nice touch too. We woke up to beautiful countryside views which tempted my husband into a little wander to the nearby village shop for a morning paper ( and daughters's forgotten toothbrush!)
Breakfast included croissants, fresh fruit salad, prunes, grapefruit, yoghurt, toast with choice of preserves, marmalade, even Nutella. The full English cooked breakfast was lovely which we thought was just the right amount, though may not be enough for some people. The guest lounge was relaxed and comfortable with a large selection of books, videos and toys suitable for all ages and tastes. All in all a relaxing and extremely good value (for this area in particular) B&B, will definitely be back hopefully for a longer stay next time and would definitely not hesitate in bringing my younger children. (On their best behaviour though as the room's sound proofing not great with it being an older property.)
Read More Less
Quiet place int Bathford
Lovely cottage in Bathford, nicely decorated rooms.
Very friendly landlady. Good pub within walking distance: crownbathford.co.uk
Read More Less
Lovely character B&B
We usually stay in hotels but chose a B&B for a change.
It was a lovely place and lady running it was really nice. Room was lovely and clean and had all we needed. Although we still prefer hotels I would recommend garston cottage for character and personal factor
Read More Less
Could not fault it
Excellent place for us to base ourselves for mini break in Bath.
lovely room for 3 of us with delightful view across rolling hills. Lovely lounge area we could use with extensive DVD and video collection making it a home from home when required on rainy day. Bus to Bath 3 minute walk away, preventing need to take car in on busy Friday. Good resources available for ideas of things to do. Breakfast was amazing.
Read More Less
Garston Cottage
Very average B/B.
A bit too far away from the nearest pub/restaurant unless taking the car. Small room. Very pleasant owner. Traditional breakfast good.
Read More Less
lovely room, great breakfast
Our lovely bedroom looked out over the cricket pitch and countryside beyond -between the houses opposite.
The weather was lovely too. Large well cooked breakfast and helpful hostess. Very easy to get into Bath from the cottage
Read More Less
A very nice place to stay.
Food and quality of the accommodation is first class and the place has a proper 'home feeling'. Location is in a quite village location, but not too far to drive into Bath. Lovely views of the countryside around.
Read More Less


text:
Molten Sky by KaatmanWatch
©2011-2016 Kaatman
Taken from the summit of Mount Tolmey in Victoria, BC.
Photographer: Kaatman
Photographer: Kaatman
amazing colors!
Thank you, but I can't really claim much credit, this is one of the two or three pictures I ran through a photoediter. Not what the original picture looked like, but it's what I remember that sunset looking like.
was this edited in any way?
was this edited in any way?
that's relly pretty...


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Is there a self-consistent schrodinger-poisson solver on nanohub?
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Are you Rosemary J Santulli?Claim your profile
Publications (30)120.85 Total impact
Article: Suzuki−Miyaura Approach to JNJ-26076713, an Orally Active Tetrahydroquinoline-Containing α V β 3 /α V β 5 Integrin Antagonist. Enantioselective Synthesis and Stereochemical Studies[Show abstract] [Hide abstract]
ABSTRACT: An improved scale-up synthesis was required for the alpha(V)beta(3)/alpha(V)beta(5) integrin antagonist 1, which had demonstrated oral efficacy in eye disease models of angiogenesis and vascular permeability. A stereodefined, quinoline-substituted, unsaturated ester was conveniently prepared by a Suzuki-Miyaura coupling to facilitate exploration of multiple methods of asymmetric reduction. The catalytic chiral hydrogenation of the corresponding unsaturated acid (Z-5b) with a ruthenium-based metal precursor and the (R)-XylPhanePhos ligand proved particularly efficient and economical. The resulting (3S)-quinoline-containing intermediate was reduced to an equal mixture of tetrahydroquinoline diastereomers. The undesired diastereomer could be recycled to the desired one by an oxidation/reduction protocol. The absolute stereochemistry of 1 was established as 3S,3'S by a combination of X-ray diffraction and chemical means.
Article: Studies with an Orally Bioavailable V Integrin Antagonist in Animal Models of Ocular Vasculopathy: Retinal Neovascularization in Mice and Retinal Vascular Permeability in Diabetic Rats[Show abstract] [Hide abstract]
ABSTRACT: The alpha(V) integrins are key receptors involved in mediating cell migration and angiogenesis. In age-related macular degeneration (AMD) and diabetic retinopathy, angiogenesis plays a critical role in the loss of vision. These ocular vasculopathies might be treatable with a suitable alpha(V) antagonist, and an oral drug would offer a distinct advantage over current therapies. (3,S,beta,S)-1,2,3,4-Tetrahydro-beta-[[1-[1-oxo-3-(1,5,6,7-tetrahydro-1,8-naphthyridin-2-yl)propyl]-4-piperidinyl]methyl]-3-quinolinepropanoic acid (JNJ-26076713) is a potent, orally bioavailable, nonpeptide alpha(V) antagonist derived from the arginine-glycine-asparagine binding motif in the matrix protein ligands (e.g., vitronectin). This compound inhibits alpha(V)beta(3) and alpha(V)beta(5) binding to vitronectin in the low nanomolar range, it has excellent selectivity over integrins alpha(IIb)beta(3) and alpha(5)beta(1), and it prevents adhesion to human, rat, and mouse endothelial cells. JNJ-26076713 blocks cell migration induced by vascular endothelial growth factor, fibroblast growth factor (FGF), and serum, and angiogenesis induced by FGF in the chick chorioallantoic membrane model. JNJ-26076713 is the first alpha(V) antagonist reported to inhibit retinal neovascularization in an oxygen-induced model of retinopathy of prematurity after oral administration. In diabetic rats, orally administered JNJ-26076713 markedly inhibits retinal vascular permeability, a key early event in diabetic macular edema and AMD. Given this profile, JNJ-26076713 represents a potential therapeutic candidate for the treatment of age-related macular degeneration, macular edema, and proliferative diabetic retinopathy.
- [Show abstract] [Hide abstract]
ABSTRACT: Structural modification and cellular adhesion inhibition activities of pyridazinone-substituted phenylalanine amide alpha(4) integrin antagonists are described. Functionality requirements for the arylamide moiety and the carboxylic acid group were demonstrated. The study also revealed novel structure-activity relationships (SAR) for arylated pyridazinones. A correlation between bioavailability and permeability was also explored. A selected compound showed effectiveness in a mouse leukocytosis study.
- [Show abstract] [Hide abstract]
ABSTRACT: We report the design, synthesis, and binding affinities of a family of cyclic RGD peptides attached to type VI beta-turn scaffolds. The analogues prepared exhibit interesting binding data to the isolated receptors alphavbeta3 and alphavbeta5. The results demonstrate the utility of these type VI beta-turn scaffolds for the constraint of biologically relevant peptides.
Article: Synthesis and Biological Evaluation of Novel Pyridazinone-Based α 4 Integrin Receptor Antagonists[Show abstract] [Hide abstract]
ABSTRACT: A novel series of pyridazinone-functionalized phenylalanine analogues was prepared and evaluated for inhibition of cellular adhesion mediated by alpha4beta1/VCAM-1 and alpha4beta7/MAdCAM-1 interactions. Concise syntheses were developed and applied for exploration of structure-activity relationships pertaining to the pyridazinone ring as well as the N-acyl phenylalanine scaffold. Potent dual antagonists of alpha4beta1 and alpha4beta7 were generated from an amide subseries; antagonists selective for alpha4beta7 were identified from urea and carbamate-based subseries. The pharmacokinetic properties of selected members of the series have been determined in rats and demonstrate that the use of ester prodrugs and alterations to the amide linkage can lead to improved oral bioavailability in this series. An alpha4beta7-selective member of the carbamate subseries (36c), upon oral administration, demonstrated in vivo efficacy in the mouse DSS colitis model.
Article: Selection of a 2-azabicyclo[2.2.2]octane-based α4β1 integrin antagonist as an inhaled anti-asthmatic agent[Show abstract] [Hide abstract]
ABSTRACT: The alpha4beta1 integrin, expressed on eosinophils and neutrophils, induces inflammation in the lung by facilitating cellular infiltration and activation. From a number of potent alpha4beta1 antagonists that we evaluated for safety and efficacy, 1 was selected as a lead candidate for anti-asthma therapy by the inhalation route. We devised an optimized stereoselective synthesis to facilitate the preparation of a sufficiently large quantity of 1 for assessment in vivo. Administration of 1 to allergen-sensitive sheep by inhalation blocked the late-phase response of asthma and abolished airway hyper-responsiveness at 24h following the antigen challenge. Additionally, the recruitment of inflammatory cells into the lungs was inhibited. Administration of 1 to ovalbumin-sensitized guinea pigs intraperitoneally blocked airway resistance and inhibited the recruitment of inflammatory cells.
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ABSTRACT: A series of N-carboxy, N-alkyl, and N-carboxamido azabicyclo[2.2.2]octane carboxamides were prepared and assayed for inhibition of alpha4beta1-VCAM-1 and alpha4beta7-MAdCAM-1 interactions. Potency and alpha4beta1/alpha4beta7 selectivity were sensitive to the substituent R1-R3 in the structures 6, 7, and 8. Several compounds demonstrated low nanomolar balanced alpha4beta1/alpha4beta7 in vitro activity. Two compounds were selected for in vivo leukocytosis studies and demonstrated increases in circulating lymphocytes up to 250% over control.
Article: Synthesis and Biological Evaluation of 1,2,4-Triazolo[2,3-a]pyrrole Derivatives as Alpha-4 ( α4) Integrin Antagonists[Show abstract] [Hide abstract]
ABSTRACT: In exploring for templates to devise novel antagonists for the integrins α4β1 and α4β7, was a series of compounds identified possessing a 1,2,4-triazolo[2,3-a]pyrrole structural subunit. Compound 11, for example, was found to antagonize α4β1-VCAM-1 and α4β7-MAdCAM-1 adhesion with IC50 values of 80 and 20 nM, respectively.
Article: 1,2,3,4-Tetrahydroquinoline-containing αVβ3 integrin antagonists with enhanced oral bioavailability[Show abstract] [Hide abstract]
ABSTRACT: Reduction of the quinoline ring in an alpha(v)beta(3) antagonist yielded a 1,2,3,4-tetrahydro derivative as two diastereomers, the four isomers of which were separated by sequential chiral HPLC. Two isomers had significant alpha(V)beta(3) antagonist activity with improved oral bioavailability, relative to the corresponding quinoline derivative.
Article: Piperidine-containing beta-arylpropionic acids as potent antagonists of alpha(V)beta/alpha(V)beta(5) integrins[Show abstract] [Hide abstract]
ABSTRACT: The synthesis and SAR of a new class of piperidine-based alphavbeta3/alphavbeta5 integrin antagonists is described. Replacement of an amide bond in a prototype isonipecotamide by a C-C isostere, and adjustment of the spacer length between the carboxylic acid and basic moieties, led to low nanomolar antagonists of alphavbeta3 and/or alphavbeta5 integrins with excellent selectivity versus alpha(IIb)beta3.
Article: Corrigendum to "Aza-bicyclic amino acid sulfonamides as α4β1/α4β7 integrin antagonists": [Bioorg. Med. Chem. Lett. 14 (2004) 591]
Article: Aza-bicyclic amino acid sulfonamides as alpha(4)beta(1)/alpha(4)beta(7) integrin antagonists.[Show abstract] [Hide abstract]
ABSTRACT: The design, synthesis, and biological activity of novel alpha(4)beta(1) and alpha(4)beta(7) integrin antagonists, containing a bridged azabicyclic nucleus, are reported. Conformational analysis of targets containing an azabicyclo[2.2.2]octane carboxylic acid and known integrin antagonists indicated that this azabicycle would be a suitable molecular scaffold. Variation of substituents on the pendant arylsulfonamide and phenylalanine groups resulted in potent alpha(4)beta(1)-selective and dual alpha(4)beta(1)/alpha(4)beta(7) antagonists. Potent compounds 11i, 11h, and 14 were effective in the antigen-sensitized sheep model of asthma.
- [Show abstract] [Hide abstract]
ABSTRACT: The design, synthesis, and biological activity of novel α4β1 and α4β7 integrin antagonists, containing a bridged azabicyclic nucleus, are reported. Conformational analysis of targets containing an azabicyclo[2.2.2]octane carboxylic acid and known integrin antagonists indicated that this azabicycle would be a suitable molecular scaffold. Variation of substituents on the pendant arylsulfonamide and phenylalanine groups resulted in potent α4β1-selective and dual α4β1/α4β7 antagonists. Potent compounds 11i, 11h, and 14 were effective in the antigen-sensitized sheep model of asthma. ©2003 Elsevier Science Ltd. All rights reserved.
- [Show abstract] [Hide abstract]
ABSTRACT: A new class of dual αVβ3/α Vβ5 integrin antagonists containing a central cis-fused cyclopentane ring was identified. Because of its increased structural rigidity, the indenopyrrolidine ring system provides insight into the active conformation of other αVβ3 ligands. A concise synthesis of the indenopyrrolidine ring system was accomplished by 1,3-dipolar cycloaddition. Individual isomers of the most active compound were separated by chiral HPLC and their biological activities were compared.
Article: Structure-Function Study of Quinazolinone-Based Vitronectin Receptor (αVβ3) Antagonists: Computer-Assisted Analysis of Ligand-Receptor Interactions[Show abstract] [Hide abstract]
ABSTRACT: Modification of the pendant functionalities on a quinazolinone scaffold led to potent antagonist activity for integrin V3 with selectivity over integrin IIb3. Various guanidine mimetics, linkers, and arylsulfonamides were investigated to optimize the series. A molecular model was constructed based on a published X-ray structure and used to analyze ligand-receptor interactions. We identified key interactions for the quinazolinone and arylsulfonamide groups that may explain the changes in potency in the structure-function study.
Article: Extracellular Mediators in Atherosclerosis and Thrombosis Lessons From Thrombin Receptor Knockout Mice[Show abstract] [Hide abstract]
ABSTRACT: It is well appreciated that thrombin as well as other proteases can act as signaling molecules that specifically regulate cells by cleaving and activating members of a novel class of protease-activated receptors (PARs). The utility of gene knockout strategies to define and better comprehend the physiological role of specific proteins is perhaps best exemplified in the field of thrombin receptors. The development of PAR knockout mice has provided the unique opportunity to identify and characterize new members of this novel family of GPCRs, evaluate the interaction of PARs jointly expressed in common cells and tissues, and better understand the role of PARs in thrombosis, restenosis, vascular remodeling, angiogenesis, and inflammation. Presently, 4 members of the PAR family have been cloned and identified. In this review, we examine experimental evidence gleaned from PAR-/- mouse models as well as how the use of PAR-/- mice has provided insights toward understanding the physiological role of thrombin in cells of the vascular system and vascular pathology.
Article: Structure–Function Analysis of Urotensin II and Its Use in the Construction of a Ligand–Receptor Working Model[Show abstract] [Hide abstract]
ABSTRACT: Die wesentlichen Strukturmerkmale von Urotensin II (U II), die zur Stimulierung seines G-Protein-gekoppelten Rezeptors nötig sind, wurden aus der biologischen Evaluierung synthetischer U-II-Derivate erhalten. Daraus ließ sich ein plausibler U-II-Rezeptor-Komplex entwickeln (siehe Bild), der das Einführen nichtnatürlicher Aminosäuren an Schlüsselstellen inspirierte. Vor allem der Ersatz von Tyrosin durch (2-Naphthyl)-L-alanin führte zu einer Versechsfachung der Wirksamkeit gegenüber der von U II.
Article: Arginine-Specific Protease from Porphyromonas gingivalis Activates Protease-Activated Receptors on Human Oral Epithelial Cells and Induces Interleukin-6 Secretion[Show abstract] [Hide abstract]
ABSTRACT: Periodontitis is a chronic inflammatory disease affecting oral tissues. Oral epithelial cells represent the primary barrier against bacteria causing the disease. We examined the responses of such cells to an arginine-specific cysteine proteinase (RgpB) produced by a causative agent of periodontal disease, Porphyromonas gingivalis. This protease caused an intracellular calcium transient in an oral epithelial cell line (KB), which was dependent on its enzymatic activity. Since protease-activated receptors (PARs) might mediate such signaling, reverse transcription-PCR was used to characterize the range of these receptors expressed in the KB cells. The cells were found to express PAR-1, PAR-2, and PAR-3, but not PAR-4. In immunohistochemical studies, human gingival epithelial cells were found to express PAR-1, PAR-2, and PAR-3 on their surface, but not PAR-4, indicating that the cell line was an effective model for the in vivo situation. PAR-1 and PAR-2 expression was confirmed in intracellular calcium mobilization assays by treatment of the cells with the relevant receptor agonist peptides. Desensitization experiments strongly indicated that signaling of the effects of RgpB was occurring through PAR-1 and PAR-2. Studies with cells individually transfected with each of these two receptors confirmed that they were both activated by RgpB. Finally, it was shown that, in the oral epithelial cell line, PAR activation by the bacterial protease-stimulated secretion of interleukin-6. This induction of a powerful proinflammatory cytokine suggests a mechanism whereby cysteine proteases from P. gingivalis might mediate inflammatory events associated with periodontal disease on first contact with a primary barrier of cells.
Article: Differential Expression of Protease-Activated Receptors-1 and -2 in Stromal Fibroblasts of Normal, Benign, and Malignant Human Tissues[Show abstract] [Hide abstract]
ABSTRACT: The serine proteases thrombin and trypsin are among many factors that malignant cells secrete into the extracellular space to mediate metastatic processes such as cellular invasion, extracellular matrix degradation, angiogenesis, and tissue remodeling. The degree of protease secretion from malignant cells has been correlated to their metastatic potential. Protease activated receptors (PAR)-1 and -2, which are activated by thrombin and trypsin respectively, have not been extensively characterized in human tumors in situ. We investigated the presence of PAR-1 and PAR-2 in human normal, benign and malignant tissues using immunohistochemistry and in situ hybridization. Our results demonstrate PAR-1 and PAR-2 expression in the tumor cells, mast cells, macrophages, endothelial cells, and vascular smooth muscle cells of the metastatic tumor microenvironment. Most notably, an up-regulation of PAR-1 and PAR-2 observed in proliferating, smooth muscle actin (SMA)-positive stromal fibroblasts surrounding the carcinoma cells was not observed in normal or benign conditions. Furthermore, in vitro studies using proliferating, SMA-positive, human dermal fibroblasts, and scrape-wounded human dermal fibroblasts demonstrated the presence of PAR-1 and PAR-2 not detected in quiescent, SMA-negative cultures. PAR-1 and PAR-2 in the cells forming the tumor microenvironment suggest that these receptors mediate the signaling of secreted thrombin and trypsin in the processes of cellular metastasis.
Article: Lourbakos, A. et al. Activation of protease-activated receptors by gingipains from Porphyromonas gingivalis leads to platelet aggregation: a new trait in microbial pathogenicity. Blood 97, 3790-3797[Show abstract] [Hide abstract]
ABSTRACT: The bacterium Porphyromonas gingivalis is a major etiologic agent in the pathogenesis of adult periodontitis in humans. Cysteine proteinases produced by this pathogen, termed gingipains, are considered to be important virulence factors. Among many other potentially deleterious activities, arginine-specific gingipains-R (RgpB and HRgpA) efficiently activate coagulation factors. To further expand knowledge of the interaction between gingipains and the clotting cascade, this study examined their effects on cellular components of the coagulation system. The enzymes induced an increase in intracellular calcium in human platelets at nanomolar concentrations and caused platelet aggregation with efficiency comparable to thrombin. Both effects were dependent on the proteolytic activity of the enzymes. Based on desensitization studies carried out with thrombin and peptide receptor agonists, and immunoinhibition experiments, gingipains-R appeared to be activating the protease-activated receptors, (PAR)-1 and -4, expressed on the surface of platelets. This was confirmed by the finding that HRgpA and RgpB potently activated PAR-1 and PAR-4 in transfected cells stably expressing these receptors. Cumulatively, the results indicate the existence of a novel pathway of host cell activation by bacterial proteinases through PAR cleavage. This mechanism not only represents a new trait in bacterial pathogenicity, but may also explain an emerging link between periodontitis and cardiovascular disease. (Blood. 2001;97:3790-3797)
Top Journals
Johnson & JohnsonНью-Брансуик, New Jersey, United States
Open Source Drug DiscoveryNew Dilli, NCT, India
Jagiellonian UniversityCracovia, Lesser Poland Voivodeship, Poland


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Click here to print the obituary below
Guy W. Malmborg
1952 ~ 2013
Guy was born April 4, 1952 and left this world on June 6, 2013 while doing one of the things he loved most.
Guy was born in Garfield, Utah and was raised in Magna where he attended Cyprus High School on a part time basis. He might have graduated with his class in 1970, however there was a war raging in Vietnam, and in 1969, on his 17th birthday, he enlisted in the
United States Marine Corps
. He served with the 1st Air and Naval Gunfire Liaison Company and served overseas with WESPAC ground forces. Besides this, Guy was a husband, father, brother, grandfather, master gunsmith, scuba instructor, rescue diver, drummer, photographer, welder, auto body technician, law enforcement officer, motorcycle mechanic, fly fisherman, expert rifleman and generally a good guy. He was optomistic and conservative in his views. He is known to have run into a burning building one night to rescue trapped and injured people, and it is said and witnessed by many, that he even chased down a car one night on foot, to get a hit and run, drunken driver out from behind the steering wheel and hold him until the police showed up. Guy was one to get involved, and feared nothing, except maybe Dams.
He is survived by his twin sister, Gay Flesher, sisters April (Dann) Nelson, Robyn (Steve) Wallwork and his stepbrother Steve (Dottie) Johnson. His three sons Wade (Jenny) Malmborg, Robert (Elke) Malmborg, Michael J. Hamblin and his extended family, Cassie, Moki and Maggie. Guy has three grandsons Austin, Garrett and Mason, and one granddaughter Abbie.
Guy is preceeded in death by his wife and best friend Shanna (Sammy) Malmborg, his mother Audrey Matthews Malmborg, his father Walter G. Malmborg, his brother and sister in law Craig S. (Glenna) Malmborg and his extended family, Scooter, Suzie, Peppy, Brandy, and Chops.
Funeral services will be held Friday June 14, 2013 at 3:00 p.m. at Brighton 1st Ward 2925 E Bengal Blvd. Cottonwood Heights.
Published in Deseret News from June 12 to June 13, 2013


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810 Nannies Found
Find a Nanny in Kyle, TX
Sittercity knows Kyle child care. Whether you are looking for a part time nanny or a full time nanny, we understand the importance of finding the right fit for your family.
Search Kyle nannies below. Nearby cities: Austin Nannies, San Marcos Nannies, Buda Nannies, Round Rock Nannies, New Braunfels Nannies, Canyon Lake Nannies


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Wed, 06 February 2008 at 3:17 pm
Miley Ray Dolphin
Miley Cyrus and her family have a little fun after her sold out shows on Wednesday in Las Vegas, Nevada.
Miley's mom Tish joined her as well as siblings Noah, 8, and Braison, 13.
The family did the Dolphin Trainer for a Day Program at the Siegfried and Roy Secret Garden and Dolphin Habitat at the Mirage Hotel.
Like Just Jared on Facebook
Photos: Michael Simon/Startraksphoto.com Posted to: Miley Cyrus


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Tea Tasting Classes
Tea Lady Terri Lynn Fucile hosts tea tasting sessions that allow tea drinkers to increase their knowledge and understanding of the many facets of tea. Learn about tea production from cultivation and harvesting to manufacture. Attendees will also learn the art of tasting, using professional cupping equipment and experience the nuances and subtleness of this art. Class sizes are kept small. Pre-register in person or by calling the shop at 626-0130.
$25, includes booklet and take home gift.
Find International House of Tea on Facebook
Next set of sessions will be in the Autumn of 2015. Join our email list or facebook page for updates.


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Health Insurance
AMA Insurance provides physicians and their families access to a broad range of health insurance programs.
Group Hospital Income Insurance
Call for a Quote: 1-888-627-5883 (8 am – 5 pm CT, M – F)
Help reduce the impact on your budget of unexpected and uncovered hospital expenses. If you or a member of your family became hospitalized, you could be left with deductibles, co-pays and other hospital related expenses not covered by ordinary hospital insurance.
AMA-Sponsored Hospital Income Plan
- Can pay you up to $500 a day for every day you or any covered family member is hospitalized by any covered injury, pregnancy, or illness
- Benefits are paid directly to you, or anyone you may choose, to use any way you wish.
- Use benefits toward deductibles and co-pays, or everyday expenses at home, or perhaps toward a private room upgrade.
Find out how affordably the Hospital Income Insurance Plan can fit into your overall protection program.
Underwritten by:
New York Life Insurance Company
51 Madison Avenue, New York, NY 10010
On Policy Form GMR-FACE/G-29346-1
Under Group Policy No. G-29346-1
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Visit our enrollment site to enroll onlineEnroll Online
Select your state and download an application to apply by mail.
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8 am – 5 pm CT, Monday – Friday or send us a note. You can also submit a request to receive more product information by mail.


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Beyonce Knowles stole the show at last night's (31AUG06) MTV Video Music Awards with a jaw-dropping performance of her new record.
The superstar showed off her sexy new image as she performed new girl power anthem RING THE ALARM.
IniTIally wearing a full-length trenchcoat, like her angry character in the Ring The Alarm video, Beyonce performed a stunning dance routine with 10 lookalikes before revealing a basque outfit underneath.
The R+B queen won a standing ovation as she finished the performance in the fetching patent leather outfit on a hydraulic stage high above the audience.
Her performance was one of many showstoppers at the 2006 VMAs - the Pussycat Dolls joined Ludacris and Pharrell Williams, Christina Aguilera thrilled with new single Hurt, and Justin Timberlake and Timbaland performed US number one SEXYBACK to open this year's show.
Other performers included rapper TI, Shakira and Wyclef Jean, Ok Go, The Killers and ALL-AMERICAN REJECTS.
Watch Beyonce's Deja vu Video


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Excellent point...Wal-Mart's cash flows are much better than those of the U.S. - making them more credit worthy. I made the same point in a comment to my article "Blue Light Special on Wal-Mart Stock" - http://seekingalpha.com/article/277258-blue-light-special-on-wal-mart-s-stock
For one thing: Wal-Mart does not have bipartisan management bickering on how to spend money.
Walmart is the largest retailer on earth but why it is not getting as much adulation as is enjoyed by AMZN.com which is going on increasing variety of business and stringing along investors (by hanging a bottle of water in front of a runner ) with a promise of profit in future (it is no more in incubation period ). What is the model of valuation of security- does p/e mean anything anymore? why people all the time are bringing in sales and ebitda all the time? you have to come to the bottom line, the earnings available for equity holders- why to earn $1.0 I have to pay more to one party than the other? Why WMT's p/e is not at par with AMZN.com?
Walmart's own people are saying customers are having trouble comi9ng up with the cash to shop even there. Doesn't sound so safe to me. Although if WMT isn't safe, what is?
Um...... Apple doesnt issue corporate bonds.
Though a sequel for "The Muppets" has been greenlit, a single star who was integral to bringing the franchise into the new millennium will not be a component of it, reports Collider.
Jason Segel told the site he won't be signing up for another round with Kermit and Co. "It's correct [that I won't be inside the sequel]," stated Segel, "but it is totally amicable. My objective was to bring the Muppets back and I did that, leaving them in very great hands." Segel stated he desires "to pursue a lot more human-related projects," adding, "All I wanted to complete was to set the stage for them to do whatever they wanted. I'm confident I'll return in some capacity right here and there, but that was half a decade of my life. 5 years of challenging function. I am ready for a bit puppet break."


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Ladies of Shipping Netball Fund
Event: Chloe Rogers's fundraising
Chloe Rogers
£640.00 raised of £400.00 target
30 donations
My Target:
£640.00 raised so far
How to make a donation
Donate online at - www.justgiving.com/ShippingLadiesNetball
By mobile internet Scan this code on your smartphone to go straight to Chloe Rogers's page.
By text message to donate £10 Text ABNA97 £10
to 70070
The renovation of the 110 year old ship, the Chauncy Maples, will bring basic healthcare to 500,000 lakeside people in Malawi.Inspired by this visionary goal, we, the Ladies of the Reed Smith Shipping Department, have chosen to use the first Annual Ladies vs. Gents Netball Match to raise a few bob in order to help the Chauncy Maples Malawi Trust reach its funding target.
And so, the challenge has been set! Should we raise £300, our fearless gentlemen colleagues will wear wigs during the game. Should we raise £400, they will wear wigs and skirts!As frightening as that may sound, please dig deep and help us support this excellent cause. And, let's face it, it should all be good fun too!
We should mention, of course, that the Gents are running a similar JustGiving page so please feel free to support them - all the money goes to the same place - but we firmly believe our target, if reached, will have the most entertaining results.Thank you.
Sarah Choudhry, Thor Maalouf, Lucy Longmore, Angela Hampshire, Charlotte Davies, Cristin MacCann, Anja McGuiness and Chloé Rogers
Updates 0
Raising money for
Chauncy Maples Malawi Trust
Charity Registration No. 1140117
Chauncy Maples Malawi Trust is developing vessel-led solutions to bring greatly improved healthcare to isolated communities on Lake Malawi. This will lead to increased school attendance, fewer working days lost to preventable illness, and better life chances for these communities.
Raising money for
Run by Chauncy Maples Malawi Trust
Charity Registration No. 1140117
Donations 30
Well done, girls!!
Donation by Sejal Gandhi on 30/12/10
+ £2.82 Gift Aid
Not sure what will be moreuncomfortable to watch: male colleagues in skirts and wigs or male colleagues cry on losing. Good luck, ladies!
Donation by Helle Kjaerstad on 19/11/10
+ £5.64 Gift Aid
Good luck girls!! :-)
Donation by Antonia Panayides on 19/11/10
+ £4.23 Gift Aid
Donation by Halani Lloyd on 19/11/10
+ £8.46 Gift Aid
Donation by Ruth Allan de Maldonado on 19/11/10
+ £5.64 Gift Aid
Good luck!
Donation by Anjulie Rao on 19/11/10
+ £5.64 Gift Aid
Donation by Rebecca Archer on 17/11/10
+ £2.82 Gift Aid
Go girls!
Donation by Angela Hampshire on 17/11/10
+ £5.64 Gift Aid
Good Luck!!!!!!!!!!!!!!
Donation by Ewa Szteinduchert on 17/11/10
Good luck ladies!
Donation by Frances Callanan on 17/11/10
+ £2.82 Gift Aid
Good luck, ladies.
Donation by Rajeev Philip on 17/11/10
+ £8.46 Gift Aid
Good luck
Donation by emma farley on 17/11/10
Good luck!
Donation by Aminder Khatkar on 17/11/10
+ £5.64 Gift Aid
Donation by Belinda Paisley on 17/11/10
+ £14.10 Gift Aid
God speed.
Donation by James Norris on 17/11/10
+ £5.64 Gift Aid
Best of Luck girls!! Remember the cheeky bounce-pass!! x x
Donation by Lexi Civil on 17/11/10
+ £1.41 Gift Aid
Go ladies! I'm just sorry I won't be there to see grown men in skirts helplessly chasing the ball round the court...let alone crying on defeat
Donation by joanna whiteman on 17/11/10
+ £8.46 Gift Aid
Good luck, girls! Though I'm sure you won't need it ;)
Donation by Alex Allan on 16/11/10
+ £4.23 Gift Aid
A win should be embarrassingly easy for the girls. Best of luck.
Donation by Samantha Roberts on 15/11/10
+ £8.46 Gift Aid
Go for it ladies - may the force be with you...
Donation by Madeleine Kombogiorgas on 15/11/10
Enjoy :) Hope David doesn't cheat too much xxx
Donation by Leilani Rogers on 14/11/10
Donation by Lucy Longmore on 12/11/10
+ £4.23 Gift Aid
Donation by Thor Maalouf on 12/11/10
+ £8.46 Gift Aid
Watch that footwork boys...!
Donation by Cristin MacCann on 11/11/10
+ £5.64 Gift Aid
I shall expect photographic evidence that the chaps took their beating like men :-) Bring it ladies xxx
Donation by Angela Rogers on 11/11/10
+ £5.64 Gift Aid
Donation summary
- * Online donations£570.00
- Offline donations£70.00
- Text donations£0.00
- Total raised£640.00
- Gift Aid£145.26
* Charities pay a small fee for our service. Find out how much it is and what we do for it.


text:
Yes, I know the Iron & Wine show tonight has been sold out for months (not to mention the Vera Project show last night), but
Yes, I know the Iron & Wine show tonight has been sold out for months (not to mention the Vera Project show last night), but good news: if you have no ticket, you can still go see Iron & Wine folk poet Sam Beam at Sonic Boom Records in Capitol Hill tonight at 6 p.m. for free (and it's all ages, of course).
Then you might want to celebrate Cinco De Mayo with one of our favorite local purveyors of rhyme, Dyme Def. They have a show at the High Dive tonight with Big World Breaks and Theoretics. That starts at 9 p.m. and costs $8. More on Cinco de Mayo music later, but this is where I'd spend my evening if I was looking for someplace to get rowdy.
Rocco Deluca, Joshua James at Neumos, 8 p.m., $15
The touchstones are clear. Rocco DeLuca (pictured courtesy Daniel Lanois) is fond of Led Zeppelin, and finds footholds in the same hard-blues that Jack White has turned into a career of reductive reinterpretation. DeLuca is not just an amalgam of his influences, though, offering uncommon interpretations on common themes. DeLuca's sound resides somewhere between the soil and the sky; his frequent use of dobro highlights the push and pull of earthy and ethereal, paring its steely sound against the haunting effect of sinewy slide work. DeLuca's rhythm section, The Burden, keep the songs driving forward with a feel that's not quite rhythm and blues, not quite rock & roll, and DeLuca's vocals capably handle a range of dynamics and moods, feeling just as steady in tortured howls as in subtle crooning, proving DeLuca as capable and engaging a singer as any of his contemporaries. Though cries of cribbing are a given, DeLuca rises deftly beyond his influences, even as his music openly announces them. What more can we ask? NICHOLAS HALL


text:
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Cleveland Clinic employees enjoy excellent health, dental and vision plans, paid time off, tuition programs and pension plans. Whether your career goals are better suited to a major tertiary medical center or a community hospital setting, Cleveland Clinic has employment options that will allow you to take your healthcare career to the next level. Don't pass the opportunities by! Explore Avon Lake Family Health Center jobs with Cleveland Clinic.
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Results 1 – 12 of 12 Page 1 of 1
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|MT/ MLT(Med Tech/Med Lab Tech) Job
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|Medical Assistant JIC- Family Health Center - EXTERNAL ONLY Job
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|Medical Assistant Interview Event JIC - Main Campus, Community Hospitals & NEO Centers
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|Jan 31, 2016
|Medical Assistant JIC-EXTERNAL ONLY Job
|Jan 25, 2016