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Klinsmann sounds more confident on eve of opener
With video report
|United States' head coach Jurgen Klinsmann does push-ups before an official training session the day before the group G World Cup soccer match between Ghana and the United States at the Arena das Dunas in Natal, Brazil, Sunday, June 15, 2014. (AP Photo/Julio Cortez)
NATAL, Brazil — Jurgen Klinsmann speaks with pragmatism. He books his airline tickets with hope.
The U.S. coach caused a stir in the lead-up to soccer's championship when he said that "I think for us now, talking about winning a World Cup is just not realistic."
But on the eve of the Americans' opener against Ghana, he revealed this: "I booked my flight after the final."
The U.S. has never advanced after starting with a loss, and it is grouped with the 37th-ranked Black Stars along with No. 2 Germany and No. 4 Portugal.
A two-day downpour has flooded some streets in this northeastern Brazilian beach town. While the skies started to clear a bit Sunday, the forecast was unsettled for tonight's game, when the Americans try to avenge losses to Ghana that knocked them out of the past two World Cups.
Klinsmann sounded just like the U.S. Postal Service.
"It's raining. If it's snowing. If it's — what else? — thunder or lightning ... field wet, field dry, heat, humidity, whatever," he said Sunday. "We're not worried about that stuff at all."
A total of 3.11 inches of rain fell Friday and 2.95 more Saturday, according to AccuWeather's Anthony Sagliani, and by late Saturday night cars had to navigate at least 18 inches of standing water. Natal's City Hall declared a flood alert and evacuated dozens of residents as a precaution in the Mae Luiza neighborhood in the city's west.
Still, the field appeared firm during workouts Sunday at the new Arena das Dunas, whose wavy, asymmetrical exterior was designed to resemble the nearby sand dunes of a city nearly as close to west Africa (1,800 miles) as to the American base camp in Sao Paulo (1,400 miles).
The forecast calls for a temperature of about 80 degrees (27 Celsius), high humidity — Natal is 400 miles south of the equator — and a slight chance of showers.
"The weather is what it is, and as players that's not something we can control," midfielder Michael Bradley said. "You get to this point, you're not worried about little details, about whether the wind is blowing, whether the sun is out."
Thousands of U.S. fans are expected. The American Outlaws supporters group chartered two Boeing 767s from Houston that brought 530 fans to Brazil, and the U.S. Soccer Federation said it sold its official allotment of about 2,000 tickets.
Ghana beat the Americans by identical 2-1 scores in the final group-stage game at Germany in 2006 and in the second round at South Africa four years ago. The U.S., appearing at its seventh straight World Cup and 10th overall, has never lost to a team three straight times in the tournament.
"It's going to be like they're coming for revenge," said Ghana captain Asamoah Gyan, whose overtime goal was the difference in the 2010 match.
Teams that won their openers have advanced 85 percent of the time since the 32-nation format began in 1998. Just 9 percent of nations starting with a loss advanced, and 58 percent of those beginning with draws reached the knockout rounds.
"This is just an awesome moment, because that's the biggest stage you can have, where you kind of want to show that you improved, and nothing better than against the team that beat you the last two World Cups," Klinsmann said. "So this, as we mentioned before, is like start the whole World Cup with a final."
Ghana lost a shootout to Uruguay in the 2010 quarterfinals. The Black Stars are the youngest of the 32 World Cup teams with an average age of 25 years, 6 months, according to FIFA, while the U.S. is the 12th-oldest at 27 years, 10 months.
"Now people back home believe we can do more, which puts pressure on the players," Gyan said.
Barring late injuries, Tim Howard will be in goal, and Fabian Johnson figures to start at right back, Geoff Cameron and Matt Besler in central defense and DaMarcus Beasley at left back. Kyle Beckerman, Jermaine Jones and Bradley anchor the midfield, and Clint Dempsey and Jozy Altidore will be up front. The fourth midfielder likely will come from among Alejandro Bedoya, Graham Zusi and Brad Davis. Beasley would become the first American to play in four World Cups.
The Americans will wear their red white and blue road uniforms. While confident, Ghana coach James Appiah sounded wary.
"America years back I believe was more interested in baseball," he said. "They are a big football country now."
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This paper reports an efficient synthesis scheme for pseudorandom pattern generators (PRPGs) of arbitrary length. The -bit PRPG, synthesized in linear time , generates quality pseudorandom patterns leading to a highly efficient test logic for the very-large-scale integration (VLSI) circuit. The cascadable structure of proposed -cell PRPG is utilized to construct the -cell PRPG, in two time steps, without sacrificing the pseudorandomness quality. This eases the design of on-chip test pattern generators for the system-on-a-chip implementing multiple cores. It avoids the requirement of disparate test hardware for different cores and thereby ensures drastic reduction in the cost of test logic. The effective characterization of nonlinear cellular automata (CA) provides the foundation of such a design. Extensive experimentation confirms the better efficiency of the proposed test structure compared to that of the conventional designs, developed around maximal length CA/linear feedback shift register of complexity.
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text:
thank you, just the sound I was looking for!
Like ur garden! And thanks for the nice sound =)
this is great thank you :)
Yup, I'm very happy with it... and the fact that it has got phantom power. I tested it yesterday, with a superlux mic, and it worked like a charm. I'll upload something later today, I hope.
This is realy beatiful. The recorder is very good indeed.
Thanks Inchadney :)
It was recorded while i was on a coffee break, when at work. Juuuust before every tourist in Henne beach woke up, so no traffic noise. But the beach waves are too far away, i'll give you that. But the atmosphere was nice, and i thought i'd record it. Next project is to get a wind jammer, but perhaps i'll make one myself, with foam inside. I think the internal mics are too close to the actual "fur" otherwise. We'll see how it turns out though... or more accurate, hear how it turns out :)
Klankbeeld, I think the next buy is a good deal out in the future. I've been saving up for quite some time, to get my hands on this recorder. Part of the reason, for making my own wind jammer too. Cash flow is really low now ;)
Great recorder. No up for the Rode NT4 ;-)
Congratulations to the new recorder! : ) Nice track...but get closer to the sea ; ) and as a windshield the dead kitten from Rode might work!
Thanks Man, You Saved My Life, I Will PM You The Link To The Video When It's Done!
It's made with Gespeaker, a voice synth for linux :)
How Did You Make This?
It's Epic!
Perfect, thanks!
A nice steady 'swishing' sound, perfect for what I might use it for!
Sounds good, but WAY too long. Just silly.
Hi there! I used this file in a performance of "The Tell-Tale Heart":
Thank you!
Thanks, i think i was rather lucky with this recording :)
A beauty again :-O
This is perfect, exactly what I was looking for! (although I'm picturing it in France :P)
Yes, it's there.
Great sound. Thank you!
Making ambient background for a session of Pathfinder with my gaming friends as this is so perfect! Thanks!
Nice one, thanks. Used it in http://snd.sc/Y25Twn (The link may change, I'm not done with it yet)
Sounds nice...
Thanks :)
great recording
Fantastic! That is what we need! Great quality! Thx!
Thanks very much x:-)Wally
Very peculiar and nice. Thanks.


text: I was just wondering if anyone has found a place online that sells those puffy hub cleaners that sit on your hub and clean it while your riding. I have one that my friend gave me, but he had gotten it from someone on a trip in japan. A while back i remember stumbling on a place that sells these but i cant seem to find it again. ok heres the pic


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Rocking Without Vowels
If you listen to any track off of XBXRXs latest album, Wars, youll immediately understand the CDs title -- every song sounds like a battle cry. The Oakland, California band has been making posthardcore thrash music for nearly 10 years and opening for bands like Sonic Youth and Deerhoof along the way.
As teenagers, the XBXRX bandmates had humble beginnings. Their first gig was a friends birthday party, and their first tour involved Moms van. But despite what some detractors view as an inaccessible style focused more on energy than on structure, the band has developed a strong following for its explosive live performances fueled by heavy guitar lines, screaming vocals, balloons, lights, and dance riots. Of course not everyone agrees: One blogger called the bands live show an animalistic seizure of grunts and yips with no redeeming value. But for anyone who has ever looked to music for catharsis, thats just what makes this group worth watching. XBXRX will be parading anger -- alongside local heroes Laundry Room Squelchers, Ha Ha Help!, and Foreign Bodies -- tonight at 9:00. Of course its at Churchills.
Sun., July 29, 9 p.m.
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text:
The day-after Page One article on Katrina, whose full impact would become even clearer in subsequent days. Today...
page 2 is utterly illegible. bad show.
Anonymous: Use the PDF version to read page 2.
where's the actual article. All I get is the overview.
Yes, as Mike suggested, in the Document Viewer, hit the button with the four arrows that is called "View Document in Full Screen," and then you'll see a choice on the right rail for calling up the actual PDF. That PDF is pretty readable, at least as readable as these old clips will ever get. Thanks all, for reading!
Fascinating article. It illustrates well a very different economy -- much more government managed -- than the one we have today. Interesting how there are hints of the planners' attempts to hold onto controls over pricing, wages, production volumes at war's end. The planners did not want to let go of their influence over private enterprise and consumption, despite the cessation of hostilities. I suppose it is a credit to Truman that the war-time economic controls were de-constructed, allowing free market forces rather than government meddling steer the nation to prosperity.
I was 7yro when this happened. I remember my mother taking us to church in thanksgiving and to pray for a family member on Saipan w/USAAC. I also recall 4/12/45 the day FDR died. The newsboy brought an"Extra". In some ways the world has changed,however in other ways nothing has changed. The bad guys are still out there probing for weakness
Bretton Woods ... designed to get Germany in peace on their feet ... insist (we did win the war) that become "more like us" ... being different cause a mess (understatment)
Great – I should definitely pronounce, impressed with your website. I had no trouble navigating through all the tabs and related information ended up being truly simple to do to access. I recently found what I hoped for before you know it in the least. Reasonably unusual. Is likely to appreciate it for those who add forums or anything, web site theme . a tones way for your client to communicate. Excellent task.


text:
Basic Gopro 3 Gimbal for the DJI F450 frame
by Maxxi, published
Thing Info
A basic Gopro 3 gimbal for the DJI F450 frame.
The gimbal in the picture is from the first version of this published version. The swivel arms and backplate are now combined in 1 piece.
On my gimbal I use cheap Hextronik MG14 metal gear servo's. Not sure how long they last in this setup. ;)
YT vid of the first version gimbal:
Thing Info
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Which servos are we using here ?
Hello, could you give some information regarding the electronic side, do you use Arduino micro-controler ? ... thankyou
Hi, I just use the built-in DJI Naza gimbal controller. It works great for this setup.
And you can directly connect the servo motors to the DJI Naza controller ?
Yes, you can. :)
After tweaking the servo travel and gain settings in the DJI NazaM Assistant software you're good to go.
anyway to customize that for the DJI Phantom?
That would be possible but I don't have the measurements for the Phantom.
18mm from bottom of DJI GoPro case and 90mm from bottom of Phantom body.. as far as the the mounting holes, i need to wait till i get home to measure that.. So far I havent found it online.
I might be able to use this one, but not sure if I will have the clearance.
The height of this Gimbal is around 80mm so that should work. It even looks like the Phantom has more clearance than my F450 with printed landing gear.
Drilling extra holes in the main mount shouldn't be a problem either.
I will give it a try, what thickness did you print that at?
ABS at 220C, 0.2mm layer height, 2 perimeters and (I think) 80% rectilinear infill. Might have been 100% infill but I can't remember. :)
great thanks!
I made one, but had to modify it to fit my servos.. Kinda pushing it though, not enough support on the roll axis. might have trimmed too much off.
Sorry for the late reply. I haven't gotten any chattering issues. Maybe it's because of the metalgear servo's I use(although still cheap).
Only one issue came up with those servo's. When mounting them you have to be careful not to push the shaft in too deep or the gearing mechanism locks up. I use a screwdriver to lift them out a tiny bit after mounting.
If your servo's are smaller then my Hextronik ones I think they might not me able to cope with the weight of the tray and arm or your gain settings are too high.
I have both pitch and roll set to 20 at this moment. Haven't played too much with the settings because they're pretty good at this point.


text:
Beth shows David her awful rash and tells him Nick can expect a visit from Environmental Health.
Beth shows David her awful rash and tells him Nick can expect a visit from Environmental Health.
Under the police officer's' gaze, Simon's adamant that the incident involving Kyle was a genuine accident, but when it's obvious neither the police nor Ken believe him, he loses his temper and thu
As Michelle and Carla arrive for the wedding fayre, they're annoyed to see Tracy and Robert there with a stand for the florists.
Desperate for her painkillers, Carla finally admits she had a one-night stand with Robert, but it meant nothing.
Sinead enjoys modelling the new underwear range, but while the O'Driscolls are impressed, Chesney remains uneasy.
Phelan explains to a horrified Anna that Jason's given him some work so he'll be sticking around. Anna finally flips before Gary or Izzy can stop her and sets about smashing up Phelan's van.
Appalled by Anna's behaviour, Kevin orders Gary to take her home. Meanwhile, Jason leads Phelan back to No 11 where Eileen insists he stays for dinner.


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Rising sea levels cannot be stopped over the next several hundred years, even if deep emissions cuts lower global average temperatures, but they can be slowed down, climate scientists said in a new study.
A lot of climate research shows that rising greenhouse gas emissions are responsible for increasing global average surface temperatures by about 0.17 degrees Celsius a decade from 1980-2010 and for a sea level rise of about 2.3 millimeters a year from 2005-2010 as ice caps and glaciers melt.
Rising sea levels threaten about a tenth of the world's population who live in low-lying areas and islands which are at risk of flooding, including the Caribbean, Maldives and Asia-Pacific island groups.
More than 180 countries are negotiating a new global climate pact which will come into force by 2020 and force all nations to cut emissions to limit warming to below 2 degrees Celsius this century - a level scientists say is the minimum required to avert catastrophic effects.
But even if the most ambitious emissions cuts are made, it might not be enough to stop sea levels rising due to the thermal expansion of sea water, said scientists at the United States' National Center for Atmospheric Research, U.S. research organization Climate Central and Centre for Australian Weather and Climate Research in Melbourne.
Via Dr. Stefan Gruenwald


text: Have your children succumbed to the craze over the last couple of years? Silly Bandz are little silicone bracelets that retain their shapes. I know, I know, they aren't exactly breaking news as far as kid fads go, but things take awhile to reach our mountain hovel. Almost two … [Read more...]


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Originally posted by Illusionsaregrander
Once YOUR MIND attaches significance to a set of numbers, it notices them, and "marks" them as significant. If someone else tracked your "number seeing" over the course of the day, (someone or something objective) it would become clear that you see tons more insignificant numbers than significant numbers. But because your brain makes a big deal out of numbers it has already decided are significant when it happens to see them, you assume that seeing them itself is significant, when its not.
Thats the scientific explanation simplified. But Im sure the magical explanations will be much more appealing.edit on 6-6-2011 by Illusionsaregrander because: (no reason given)
Originally posted by Sandbar
reply to post by Sly1one
Thanks for the input. I would dismiss this whole thing if I was seeing the numbers during the day...which I do not. I only experience this when I awake from a sound REM sleep. Hmmmm.


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In Tibetan Buddhism, skulls are often used in ritual practices. Skulls signify impermanence and encourage a life of compassion.
Handcrafted: Skillfully created by artisans. Naturally occurring variations may be present, adding to the unique beauty of each piece.


text:
Posted on So whats the deal with all the "Spamembers"
#1 posted 10-20-2012 06:33 PM
Of course if NOBODY on any site EVER clicked through to the advertised sights, they would give up!
I doubt that, since they obviously don't have anything better to do. But that aside, there's more to it than getting traffic directly. There is also the matter of search engine optimization (SEO). The more inbound links they have scattered around the web, the better their site looks to search engines. And deep linking is the best – ie, links not to their home page but rather, links to TheirWebsite/Articles/Topic/LameContent.html
The smart ones (for lack of a better term) place links in their signature so they can go through and change them occasionally.
-- There are three types of people in this world... those who make things happen, those who watch things happen, and those who wonder what happened.


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text:
James Martin Barron
Position: T
Height: 6-0 Weight: 195 lbs.
Born: November 10, 1888 in Boston, MA
Died: February 6, 1936 in Boston, MA
High School: Boston College
College: Georgetown (DC)
Weighted Career AV (100-95-...): 0 (15060th overall since 1950)
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Book your room at Homewood Suites Rochester Henrietta
Suite, One King Bed, Non-SmokingMax Occupancy: 4 guests (up to 3 children, 3 infants)
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Suite, One King Bed, SmokingMax Occupancy: 4 guests (up to 3 children, 3 infants)
Suite, Accessible, Non SmokingMax Occupancy: 6 guests (up to 5 children, 5 infants)
Bedroom Suite Two DoublesMax Occupancy: 6 guests (up to 5 children, 5 infants)
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Two Bedroom Suite, Two King Beds, Non-SmokingMax Occupancy: 6 guests (up to 5 children, 5 infants)
Get an overview of this hotel3-star hotel with free breakfast and indoor pool
Situated in Rochester, this hotel is within 2 mi (3 km) of Veterans Memorial Park, Fair and Expo Center, and Marketplace Mall. Bill Gray's Regional Iceplex and Sports Centre at MCC are also within 3 mi (5 km).
Hotel Features
Along with an indoor pool, this hotel has a fitness center and a 24-hour business center. Free buffet breakfast is provided, as well as free WiFi in public areas, free self parking, and a free manager's reception. Additionally, coffee/tea in the lobby, meeting rooms, and dry cleaning are onsite.
Room Amenities
All 90 rooms provide conveniences like dining areas and sitting areas, plus free wired Internet and TVs. Guests will also find refrigerators, microwaves, and stovetops.Information missing or incorrect? Tell us!Opens in a new window
Hotel Amenities
Hotel Amenities
Homewood Suites Rochester Henrietta features an indoor pool and a fitness center. High-speed wired and wireless Internet access is complimentary. Business-related amenities at this 3-star property consist of a 24-hour business center and meeting rooms. Guests can enjoy a complimentary breakfast each morning as well as a complimentary manager's reception on select days. This business-friendly hotel also offers gift shops/newsstands, coffee/tea in the lobby, and laundry facilities. Onsite self parking is complimentary.
- Total number of rooms - 90
- Fitness facilities
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- Free breakfast
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- Indoor pool
- Coffee/tea in common areas
- Dry cleaning/laundry service
- Free WiFi
- Free wired high-speed Internet
- 24-hour business center
- Television in common areas
Family Friendly Amenities
- Indoor pool
- Free Wi-Fi
- Laundry facilities
- Separate dining area
- Refrigerator
- Microwave
Available in all rooms: Free wired high-speed Internet
Available in some public areas: Free WiFi , Free wired high-speed Internet
Free self parking
Room Amenities
- Separate sitting area
- Air conditioning
- Microwave
- Refrigerator
- Television
- Desk
- Cribs/infant beds available
- Separate dining area
- Dishwasher
- Stovetop
- Free wired high-speed Internet
Where to Eat
Guests are offered a complimentary hot/cold buffet breakfast each morning. A complimentary manager's reception is offered on select days.
Nearby Things to Do
Recreational amenities at the hotel include an indoor pool and a fitness center.
Hotel Policies
Check-in time starts at 3 PM
Check-out time is noon
Payment types
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
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Hotel Name
- Homewood Suites Henrietta
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- Homewood Suites Rochester Henrietta
- Homewood Suites Rochester Henrietta Hotel


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Welcome to a new experience in car infotainment from LG offering you not only an acoustic sense with dynamic sound power but also a sense of sight by an emotional design technology.
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Total No. of Seats: 20 Eligibility: B. E, B. Tech., in Mechanical, production Tool and Die, Automobile and Industrial engineering How to Apply: Application forms are downloaded from website:http://www.doeacccalicut.ac.in/course/application.pdf Filled in application forms along with a DD towards advance deposit of Rs. 1,000/- drawn in favour of Director, DOEACC Centre, Calicut, Payable at State Bank of … Read more
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PG Diploma in the Teaching of English @ EFLU, Hyderabad Eligibility: Candidates must have passed Post Graduate Certificate in the Teaching of English (PGCTE) How to Apply: For an application form, you can make a request to the 'The Dean, School of Distance Education, The English and Foreign Languages University, Hyderabad' enclosing a crossed DD … Read more
University of Allahabad, Allahabad invites application forms from the eligible candidates for admission into Post Graduate Diploma in Remote Sensing and GI for the Academic Year 2012 – 2013. Selection Process: Selection of the candidate is done on the basis of written test and interview. Candidates selected for admission are requested to bring DD of … Read more
The Institution of Permanent Way Engineers (IPWE), New Delhi invites application forms for admission into Correspondence course of Diploma in Railway Engineering for the Academic Year 2012 – 2013. Eligibility: (a) Railway Personnel working as employees of Indian Railways including employees of konkan Railway, Port Trust Railways, RITES, IRCON, CRIS, CONCOR, DMRC, RLDA, RVNL, MVRC … Read more
University of Calicut invites application forms from women candidates for admission into Diploma course in Early Childhood Care and Education at University Teacher Education Centre, Vatakara for the Academic Year 2012 – 2013 Total No. of Seats: 50 exclusively for girls. (The course will be started only if an intake of 40 students are available). Eligibility: … Read more
Eligibility: (a) Railway Personnel working as employees of Indian Railways including employees of konkan Railway, Port Trust Railways, RITES, IRCON, CRIS, CONCOR, DMRC, RLDA, RVNL, MVRC and other Railway PSUs: High School / SSC or equivalent qualification with maths or science and having a minimum of 3 years experience over Railways or having 3 years … Read more


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Linking Biodiversity to Agricultural Change: Impacts of Urbanization on Two Amazonian Quilombo Communities, Macapa, BrazilEPA Grant Number: FP916346
Title: Linking Biodiversity to Agricultural Change: Impacts of Urbanization on Two Amazonian Quilombo Communities, Macapa, Brazil
Investigators: Steward, Angela M.
Institution: CUNY Graduate School and University Center
EPA Project Officer: Boddie, Georgette
Project Period: January 1, 2004 through December 31, 2006
Project Amount: $81,728
RFA: STAR Graduate Fellowships (2004) RFA Text | Recipients Lists
Research Category: Academic Fellowships , Fellowship - Geography , Ecological Indicators/Assessment/Restoration
The objective of this research is to document the impacts of urbanization on agricultural practices in the communities of Carvão and Curiau, located in upland zones within the greater Macapá region, state of Amapá, Brazil. The research will examine whether or not observed demographic shifts encourage the development of hybrid agricultural systems—those that integrate modern technologies into pre-existing, locally evolved practices. A subsequent part of this research examines how changes in agricultural practices impact agrobiodiversity (the variation of plant species within farmers' landholdings) and alter the proportional area of land-use types (changes in numbers and sizes of agricultural fields, fallows, forests, and house gardens). This research also will assess how urban expansion influences farmers' access to agricultural technologies and financial services offered by private and government-sponsored programs. This will allow for the investigation of the economic viability of smallholder agriculture in this rural/urban transition zone.Approach:
This research will use a multidisciplined approach, involving both qualitative and quantitative methods. To document changes in agricultural practices and collect data regarding communities' access to technologies and services, oral history interviews, semi-structured interviews, and household surveys will be conducted. Archives in the cities of Macapá and Belém will be visited to obtain information on the social and economic history of the region. A classification of land-use types will be completed through a landscape survey following established recommendations for the region. Using geographic information system (GIS) technology, detailed maps of present land-use types will be created. A historic map of the landscape will be developed using remote sensing imagery, Landsat images and aerial photographs. The present composition will be compared to this historic map to document changes in land-use. Biodiversity analyses will be conducted in each land-use type following the recommendations of the People Land Environment and Change Program. Larger agroecosystems will be inventoried using a random plot method while all plants in smaller agricultural areas will be catalogued. Analysis of the diversity and structure of the sample will include calculations of species richness, evenness, and diversity indices.Supplemental Keywords:
fellowship, biodiversity, agricultural practices, agrobiodiversity, Amazon, Brazil, urbanization, land use, rural/urban transition zone, agroecosystem,, RFA, Scientific Discipline, Geographic Area, Ecosystem Protection/Environmental Exposure & Risk, Monitoring/Modeling, Agronomy, International, Agricultural Engineering, environmental monitoring, urbanization, Brazil, biodiversity, urban planning, land use model, landscape-scale monitoring, Amazon, ecosystem health, agrobiodiversity, urban environment, Amazon Basin


text: The family, an entourage of 17, had a pleasant stay in this apartment. It's conveniently located near trattorias, the market and grocery. It's on the same street where the master Michelangelo, a Florentine, lived (Casa Buonarroti). The landmarks - Basilica of Santa Croce, Piazza della Signoria, Fountain of Neptune, Loggia dei Lanzi, Uffizi Gallery, Vasari Corridor, Ponte Vecchio, Palazzo Pitti,... More


text: X Vote for "Movie: The Giving of A Torah" for video of the day! Facebook Google Twitter Thank you for your vote! Share Your Vote With Your Friends Share on Facebook Tweet Share on Google+ You can only vote once per day.Come back tomorrow :). Movie: The Giving of A Torah Share on FacebookTweet Whatsapp Published: June 6, 2011 This video has 1 votes today. Add to favorites. To view your favorites click here.


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One of the more interesting bands to emerge on the Magna Carta label (a record co that specializes primarily in prog rock artists, especially collaborations/supergroups) is the aptly named Bozzio Levin Stevens. Featuring three players who many feel are at the top of their respective instruments in the rock world (drummer Terry Bozzio, bassist Tony Levin, and guitarist Steve Stevens), each member possesses quite a storied history. Bozzio first came to attention of rock fans as the drummer for Frank Zappa (appearing on such '70s-era classics as Zoot Allures, Zappa in New York, Sheik Yerbouti, etc.), before becoming a founding member of new wavers The Missing Persons, and a much sought after session man. Levin on the other hand, is primarily known as a session man (having played on such renowned albums as Paul Simon's Still Crazy After All These Years, John Lennon's Double Fantasy, Dire Straits' Brothers in Arms, etc.), but he's also been a long-standing member of Peter Gabriel's backing band, and was a member of King Crimson for an extended period as well. Like the others, Stevens has balanced his career between being a full time member of rock groups (he's best known as Billy Idol's right hand man on his best known albums, Billy Idol, Rebel Yell, and Whiplash Smile, as well as briefly working with Vince Neil), as well as session work (Michael Jackson's Bad, a Grammy award for his work on the Top Gun movie soundtrack, etc.). Never ones to pass on an opportunity to show off their immense instrumental prowess, the trio jumped at the chance to unite together and shred away. 1997 saw the release of the trio's debut album, Black Light Syndrome, which left prog rockers frothing at the mouth (especially since nearly all of the album's seven tracks either came close to reaching the ten minute mark). A supporting tour didn't happen, due to scheduling conflicts, but three years later, a sophomore effort was released, 2000's Situation Dangerous (an album that took only 14 days to record). It's anyone's guess as to when the trio will get around to issuing another recording -- as all three continue to have quite demanding recording schedules.
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Turbo: Super Stunt Squad Wii U
- Publisher: D3Publisher
- Release Date: Jul 16, 2013
- Also On: 3DS, PlayStation 3, Xbox 360
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Aug 16, 2013This is a noble effort from developer Monkey Bar Games, who shouldn't be penalized for using the Tony Hawk template; after all, games of that genre have become few and far between in recent years. So if you've been burned by the 3DS game, give Turbo: Super Stunt Squad for Wii U a try.
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David Martinez
Work out with weights.
During weight training, muscle tissue is stressed; afterward, it's repaired―which raises metabolism. A woman who strength trains three times a week for six months can build enough muscle to burn 10 to 32 extra calories a day, according to Robert Wolfe, PhD, professor of geriatrics at the University of Arkansas.


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But in our discussion, I found we agreed on some basic things. Neither of them were in favor of open borders or unconditional amnesty. Both agreed with me that national security demands a secure border. And, both agreed that some deportations were justified—as in the case of the 600,000 illegal fugitives evading standing deportation orders who need to be found and sent home ASAP.
This is good news. It could be the foundation upon which we build a national consensus to pass laws that start actually fixing the problems instead of just talking about them.
I'm encouraged.
However, I wasn't able to bring them around to my way of thinking on some other things. We didn't agree that:
1) Deportation doesn't have to break up families, children can always go home with the parent(s). If advocates demand that citizen children have the right to have both parents stay in this country with them, then the solution is to end the whole "anchor baby" interpretation of the 14th Amendment. Or,
2) That the slavery analogy doesn't work. Slaves were brought here against their will, treated like animals, and were rightfully given sanctuary because they were fleeing for their lives. Illegals come here voluntarily, are paid a wage they willingly accept, and are wrongfully given sanctuary because they are here primarily for economic not moral reasons. Or,
3) That "sanctuary" is all about awaiting a fair trial, not amnesty. The concept dates back to the Old Testament book of Numbers, chapter 35, where Moses was instructed to set up cities of refuge wherein men could await getting a fair trial before the congregation. This was to ensure that the punishment—death—fit the crime—murder. This was to avoid condemning a man to death for murder when he had only committed manslaughter.
The operative point here is that for churches to be truly biblical in their approach to sanctuary, the illegals must be awaiting a deportation trial—if a court has already issued a deportation order, then the church needs to comply with the ruling of that court and "render unto Caesar that which is Caesar's."
Thus, what Adalberto United Methodist Church in Chicago gave to Elvira Arellano and her son Saul for a whole year was not really "a sanctuary" but more accurately "a hideout."
Yet, with all the heated rhetoric in the immigration debate, I found comfort and hope in the fact that there is common ground on which I could agree with listeners like Hector and Lindsay.
Let's begin with that common ground and secure the borders and deport criminal fugitives. Then, inevitably, the debate will rage on.
But, in the short run, we'll be a safer place where the rule of law is elevated and a couple of steps will have been made in the right direction.


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Betta by RedCoasterWatch
©2011-2016 RedCoaster
Assignment for illustration media class. microns and ink. 2011
Crap! a Daily Deviation! Thanks!
Crap! a Daily Deviation! Thanks!
Daily DeviationGiven 2012-01-23
Betta by ~railrunnermiranda ( Suggested by little-billie and Featured by Mollinda )
I like the picture very much it looks like you put alot of time and your heart into it
Wow! So amazing! So the elaborate details! I love it!
Aesthetically executed and impressive detailing. Love this.
Great detail!
This is one of the most skilfully detailed drawings I have ever seen. Fantastic work!
Amazing Crowntail!
wow this amazing! Betta's are my favorite fish
aawww.. mine died a few months ago ..
Great job
Great job
8D Amazing! you have great skill!!!!
Very beautiful!
This is an awesome drawing of the Betta. I used to have a Betta. Nice job!
Betta fishes are my favorite pets, great job on the level of details. You have really captured the nature of the fish!
Gorgeous work, and love the detail in this piece. If nit-picking, I might suggest adding more hi-light to each scale to make it look "shiny". I love bettas and this really gives a feeling of flowing movement. Well done.
Awww. This pic reminds me of my 6 Bettas... They're all drama queens! XD
Wow! The details are amazing!
gotta love bettas
Simply amazing.
whaaaaaat!? thats some crazy skill
Gorgeous betta! Is he yours?
full of awesome
Gorgeous! Very meticulous and just amazing. Excellent placement of the subject, nice contrast with the background and love the fact that, just like their personalities he's to big to be contained. Love it.
5/5 Reminds me of my pet beta, Ash. He died because I cleaned his tank...
you have to leave some of the water in there when you change it because it has bacteria in it that it helps the fish.. just some tips
Congrats on the Daily Deviation!
I used to have a fish that looked just like this. He (or she, I never knew the gender) was rainbow colored.
I don't have fish anymore, but betta fish are definitely my favorite.
This is a very lovely work of art.
I don't have fish anymore, but betta fish are definitely my favorite.
This is a very lovely work of art.
its pretty easy to tell a male and a female
males have the long majestic fins
males have the long majestic fins
Yes, I was pretty sure it was a male. Just like a peacock, the males are usually more beautiful.
Lol my name is Miranda too Miranda Pavelle it's funny when I find another miranda
MArvelous !!! I Want It
This is amazing.
R.I.P Blaze, Angello, Moonlight, Bubba, and Lizzy
R.I.P Blaze, Angello, Moonlight, Bubba, and Lizzy
Wish I could draw a picture of my betta that looked this good haha
The details are amazing.
I'm amazed by the details! Wonderful
I love pen and ink ^^ cept it usually takes forever and the pens i used kepped clogging. Anyways this is awsome
Congratulations ....oh, that's nice!
Cool (:
I love to draw the fishes! But it work the best! I will be try more))
Crowntail Betta! It's beautiful. The scales are perfectly made... and I love this simple background.


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You are here: Home > Section on Physical Biochemistry
Extracellular Matrix Disorders: Molecular Mechanisms and Treatment Targets
- Sergey Leikin, PhD, Head, Section on Physical Biochemistry
- Edward L. Mertz, PhD, Staff Scientist
- Elena N. Makareeva, PhD, Biologist
- Shakib Omari, PhD, Postdoctoral Fellow
- Katrina Y. Koon, BS, Postbaccalaureate Fellow
- Lynn S. Mirigian (Felts), BS, Predoctoral Fellow (Graduate Student)
The extracellular matrix (ECM) is involved in a wide variety of disorders, ranging from rare genetic abnormalities of skeletal development (skeletal dysplasias) to such common ailments as osteoporosis, fibrosis, and cancer. Our interest in ECM biology began with studies on basic principles relating the helical structure of collagen and DNA to their interactions and biological function. Over the years, the focus of our research shifted to collagens, which are the most abundant ECM molecules, and then to ECM disorders and the development of novel treatments for these disorders. We are gradually phasing out the studies on DNA interactions and concentrating on ECM pathology in cancer, fibrosis, osteogenesis imperfecta, Ehlers-Danlos syndrome, chondrodysplasias, osteoporosis, and other diseases. Together with other NICHD and extramural clinical scientists, we strive to improve our knowledge of the molecular mechanisms underlying those diseases. We hope to use the knowledge gained through our studies for diagnostics, characterization, and treatment, bringing our expertise in physical biochemistry and theory to clinical research and practice.
Procollagen folding and its role in bone disorders
Collagens are triple-helical proteins forming structural scaffolds that hold together bone, cartilage, skin, and other tissues. In bone, they are produced by osteoblasts, the cells responsible for synthesis and mineralization of new bone material. By far the most abundant proteins in all vertebrates, collagens account for up to 30% of all proteins synthesized by osteoblasts. Yet, folding of their procollagen precursors within the endoplasmic reticulum (ER) presents an extraordinary challenge for cells. In particular, we discovered that the equilibrium state of type I procollagen in the absence of chaperones is a random coil. Folding of the human procollagen triple helix in an ER–like environment is favorable below 35°C but not at normal body temperature. At this temperature, natively folded collagen molecules become stable only after incorporation into fibers. When not incorporated into fibers, individual molecules denature within several hours and become susceptible to rapid proteolytic degradation. To overcome such intrinsic instability, cells must use specialized chaperones to fold the triple helix. It is not completely clear which chaperones are involved in this process, how they function, and how cells recognize properly folded procollagen and handle it when misfolded. Because of massive procollagen synthesis, osteoblast malfunction caused by procollagen misfolding might be an important factor in bone pathologies. For instance, osteogenesis imperfecta (OI) appears to be primarily a procollagen misfolding disease (1). Moreover, an inability of aging osteoblasts to handle normal procollagen folding load might also contribute to common osteoporosis. Understanding procollagen folding and the cellular response to its misfolding is therefore important both from fundamental and practical perspectives.
The most common mutations affecting procollagen folding are Gly substitutions in the obligatory (Gly-X-Y) n sequence of the triple helix. For example, such substitutions in type I collagen are responsible for approximately 80% of severe OI cases. The substitutions' effects on procollagen folding are determined by the location and identity of the substituting residue. Our studies of collagens from OI patients with over 50 different Gly substitutions revealed several structural regions within the triple helix where mutations might be responsible for distinct OI phenotypes. In particular, the first 85–90 amino acids at the N-terminal end of the triple helix form an "N-anchor" domain with higher-than-average triple helix stability. Gly substitutions within this region disrupt the whole N-anchor, preventing normal cleavage of the adjacent N-propeptide. Incorporation of collagen with uncleaved N-propeptides into fibrils leads to hyperextensibility and joint laxity more characteristic of the Ehlers-Danlos syndrome (EDS). Gly substitutions within an α1(I) chain region surrounding the collagenase cleavage site might be lethal because the sequence of this region prevents efficient renucleation of normal C-to-N-terminus helix folding, once the mutation is encountered.
At present, we are focusing on understanding how cells respond to misfolding of procollagen with different Gly substitutions. We hypothesize that unconventional procollagen triple helix folding requirements lead to an unconventional ER stress response and to misfolding. In collaboration with Peter Byers, we found that Gly substitutions cause slower folding as well as misfolding of procollagen, its accumulation in the ER of cultured patient fibroblasts, ER dilation, and activation of a cell stress response reminiscent of the "ER Overload" response caused by misfolding of serpin-family proteins in serpinopathies. In particular, we observed activation of autophagy and degradation of misfolded molecules in autolysosomes without activation of conventional unfolded protein response (UPR) signaling and without involvement of ER–associated degradation (ERAD) in proteasomes, providing an important clue to OI pathophysiology and a potentially important therapeutic target.
In order to pursue molecular mechanisms of the cell stress response to procollagen misfolding and its role in OI pathophysiology as well as to develop therapeutic approaches targeting the response, we are investigating a mouse OI model with a Gly610 to Cys substitution in the α2(I) chain. The G610C mouse mimics the mutation found in a large group of patients from an Old Order Amish community in Lancaster County, PA. Our study of cultured dermal fibroblasts and calvarial osteoblasts as well as tissues in this model reveals misfolding of mutant molecules without activation of the UPR, in a highly similar manner to fibroblasts from human patients discussed above. We find significant retention and accumulation of incompletely folded and misfolded procollagen in the cells, which causes ER dilation and alters normal differentiation and function of the cells. Misfolded procollagen molecules are degraded by lysosomes via autophagy, rather than by proteasomes via ERAD. In culture, calvarial osteoblasts adapt to the misfolding of mutant molecules and effectively eliminate them by enhancing the autophagy. However, the adaptation occurs at the cost of abnormal cell function, e.g., blunted response of calvarial osteoblasts to stimulation of collagen production by TGF-β and abnormal Wnt signaling. Consistent with abnormal function of the latter pathways, which are known to be important for osteoblast differentiation, cultured bone marrow stromal cells (BMSCs) form fewer colonies capable of producing mineralized matrix nodules, providing further evidence of altered osteoblast differentiation.
Development of novel OI treatments
We hypothesize that, by enhancing autophagy, it might be possible to prevent excessive accumulation of misfolded procollagen molecules in the cell, reducing cell stress and thereby improving osteoblast differentiation and function. As an initial approach to testing the hypothesis, we placed G610C mice on a low protein diet from 8 to 17 weeks of age, which reduced the swelling of ER cisternae in lumbar vertebrae osteoblasts and partially normalized mineralization of newly deposited cortical bones. However, the positive effects were counterbalanced by reduced animal growth and less deposition of new bone. Overall, our preliminary data suggest that autophagy enhancement is a useful therapeutic strategy, but a continuous low protein diet is not likely to be a suitable approach to achieving the autophagy enhancement, particularly in pediatric OI patients.
Concurrently, our study of calvarial cells and BMSCs revealed normalization of osteoblast differentiation. Surprisingly, BMSCs appeared to "remember" the animal's diet for up to several weeks at identical cell culture conditions and up to four passages. Apparently, the diet produced some epigenetic changes, e.g., resulting in enhanced autophagy even after cell removal from animals and prolonged culture, suggesting that an intermittent low protein diet might be useful for alleviating osteoblast cell stress without reducing bone deposition. However, diet affects multiple physiological functions. While the dietary treatment is easy to implement, the mechanisms underlying its effects are difficult to interpret, and even an intermittent low-protein diet may have a variety of unintended long-term consequences. It is therefore important to understand how bone formation and underlying osteoblast differentiation and function are affected by more specifically targeted autophagy manipulation that has no, or at least fewer, off-target effects. To address this question, we are currently developing mouse models with the α2(I)-G610C substitution, in which autophagy can be repressed or activated by conditional targeted deletion or overexpression of a key autophagy gene, Atg5, in cells of osteoblast lineage at different stages of their differentiation. We hope that the analysis of the animals and their cultured cells will provide a better understanding of the role of autophagy in normal function and pathology of osteoblasts as well as identify novel targets and therapeutic approaches to OI and other collagen-misfolding disorders.
Translational studies of patients with novel or unusual OI and EDS mutations
Abnormal collagen biosynthesis and malfunction of osteoblasts are also important factors in OI caused by other collagen mutations as well as by mutations in other proteins. Over the last several years, we assisted several clinical research groups in characterizing collagen biosynthesis and folding in fibroblasts from patients with newly discovered recessive forms of OI caused by mutations in cartilage-associated protein (CRTAP), prolyl-3-hydrohylase (P3H1), cyclophilin B (CYPB), the molecular chaperone FKBP65, WNT1, and an ER cation channel TRICB (2–4). In particular, our studies suggested that the CRTAP/P3H1/CYPB complex functions as a procollagen chaperone. A deficiency in any of the three proteins delays procollagen folding, although their exact role in procollagen folding remains unclear (2). More surprisingly, we found no detectable changes in the procollagen folding rate in cultured fibroblasts from patients with FKBP65 mutations. Our data suggest that FKBP65 may affect post-translational modification of procollagen and deposition of collagen matrix via a different mechanism. It remains unclear why some FKBP65 mutations cause severe OI with joint contractures (Bruck syndrome) while others cause joint contractures without pronounced OI (Kuskokwim syndrome) (3) or OI without pronounced joint contractures.
More recently, in collaboration with Joan Marini, we investigated collagen and ECM biosynthesis abnormalities caused by deficiencies of the transmembrane protein TRICB in fibroblasts from Bedouin OI patients in Israel and Saudi Arabia. The study revealed unusual underhydroxylation of lysine residues in collagen chains, in contrast to overhydroxylation of lysine caused by most other OI mutations, as well as secretion of 30–40% of procollagen molecules with abnormal conformation and reduced thermal stability. Given that TRICB is involved in Ca2+ release from the ER and that its absence causes abnormal Ca2+ concentrations and flux in patient cells, OI in these patients may be caused by dysregulation of multiple collagen-specific chaperones and modifying enzymes in the ER through Ca2+ modulation. However, TRICB may also have a more direct chaperone function in procollagen folding.
A particularly puzzling form of OI is associated with deficiencies in the pigment epithelium–derived factor (PEDF). The protein was initially described as an anti-angiogenesis factor, but the loss of function of both PEDF alleles leads to severe, progressively deforming OI (type VI) rather than out-of-control angiogenesis. In collaboration with Frank Rauch, we investigated procollagen biosynthesis and ECM deposition by cultured fibroblasts from patients with type VI OI, but detected no clear abnormalities. In collaboration with Patricia Becerra, we found that PEDF is capable of completely inhibiting collagen fibrillogenesis at concentrations comparable to its physiological level in serum, but it is presently unclear whether this PEDF property is physiologically important.
Most single amino acid substitutions in X and Y positions of the repeating Gly-X-Y collagen sequence are considered to be neutral variants. Several Arg-to-Cys substitutions were recently reported, but it remained unclear whether the resulting OI and EDS were caused by aberrant disulfide bonds formed in the ECM by the Cys residue, which is not present in normal type I collagen, or by abnormal biosynthesis of mutant molecules. In collaboration with Peter Byers, we analyzed collagen-metabolism pathology caused by substitutions of the same Y-position Arg780 in the α1(I) chain to Leu and Cys. The study revealed that the loss of Y-position Arg causes abnormal procollagen folding by reducing triple helix stability and eliminating important HSP47–binding sites. The effects are likely responsible for the bone fragility caused by Y- but not X-position Arg substitutions, while aberrant Cys disulfide bonds likely contribute to EDS in patients with either Y- or X- position substitutions.
Extracellular matrix pathology in tumors and fibrosis
Another important advance from our work of the past several years was the characterization of a collagenase-resistant, homotrimeric isoform of type I collagen and its potential role in cancer, fibrosis, and other disorders. The normal isoform of type I collagen is a heterotrimer of two α1(I) chains and one α2(I) chain. Homotrimers of three α1(I) chains are produced in some fetal tissues, carcinomas, fibrotic tissues, as well as in rare forms of OI and EDS associated with α2(I) chain deficiency. We found the homotrimers to be at least 5–10 times more resistant to cleavage by all mammalian collagenases than the heterotrimers, and we determined the molecular mechanism of this resistance. Our studies suggested that cancer cells might utilize the collagen isoform to build collagenase-resistant tracks, thus supporting invasion through stroma of lower resistance. Importantly, cancer cells produce cancer-specific isoforms of trypsin and other enzymes with altered post-translational modification. It was proposed that cancer-specific trypsins are capable of cleaving collagen triple helices at several sites. However, we found that those literature reports reflected artifacts of collagen degradation during denaturation for gel electrophoresis. Cancer-associated trypsins are not capable of cleaving the native collagen triple helix, yet they likely contribute to ECM degradation through solubilizing collagen molecules by cleaving the telopeptides involved in intermolecular cross-links (5).
We also collaborated with Constantine Stratakis's lab to investigate bone tumors caused by defects in protein kinase A (PKA), a key enzyme in the cAMP signaling pathway. Initially, we investigated synthesis of type I collagen homotrimers. However, over the last two years, the focus of the study has shifted to abnormal differentiation of osteoblastic cells and deposition of bone within these tumors. We found that knockouts of various PKA subunits cause not only abnormal organization and mineralization of bone matrix but also novel bone structures that had not been reported before. For instance, we observed free-standing cylindrical bone spicules with osteon-like organization of lamellae and osteocytes but inverted mineralization pattern, a highly mineralized central core, and decreasing mineralization away from the central core. Currently, we are assisting the Stratakis lab in characterizing abnormal osteoblast maturation, the role of abnormal inflammatory response, and effects of anti-inflammatory drug treatments in these animals. Improved understanding of bone tumors caused by PKA deficiencies may not only clarify the role of cAMP signaling but also suggest new approaches to therapeutic manipulation of bone formation in skeletal dysplasias.
Multi-modal micro-spectroscopic imaging and mapping of tissues
Label-free micro-spectroscopic infrared and Raman imaging of tissues and cell cultures provides important information about the chemical composition, organization, and biological reactions inaccessible by traditional histology. However, applications of these techniques were severely restricted by light-path instabilities in thin hydrated specimens under physiological conditions. We resolved the problem by designing specimen chambers with precise thermo-mechanical stabilization for high-definition (HD) infrared imaging and Raman micro-spectroscopy, achieving spectral reproducibility up to two orders of magnitude better than in leading commercial instruments. The HD technology was essential for analysis of abnormal collagen matrix deposition by CRTAP– and FKBP65–deficient cells (2,3). It has enabled us to assist NIBIB scientists in characterizing a functionalized carbon-nanotube approach to the delivery of anticancer agents into cells that overexpress hyaluronate receptors and is crucial for our current studies of bone structure and mineralization in the mouse models of OI and PKA deficiencies described above.
The power of the technology is best illustrated by our studies of ECM structure and composition effects on the function of cartilage in a mouse model of diastrophic dysplasia (DTD) caused by mutations in the SLC26A2 sulfate transporter, deficient sulfate uptake by chondrocytes, and resulting under-sulfation of glycosaminoglycans in cartilage matrix. In collaboration with Antonella Forlino and Antonio Rossi, we found that the deficiency results in under-sulfation of chondroitin and disorientation of collagen fibers, disrupting a thin protective layer at the articular surface and causing subsequent cartilage degradation. We investigated the relationship between chondroitin under-sulfation and the rate of its synthesis across the growing epiphyseal cartilage and built a mathematical model for the sulfation pathway, predicting treatment targets for sulfation-related chondrodysplasias and genes that might contribute to the juvenile idiopathic arthritis recently associated with single nucleotide polymorphisms in the SLC26A2 transporter.
We are extending the technology by combining imaging of bone and cartilage ECM composition and structure with biomechanical measurements at the same length scales. The mechanical properties of bone and cartilage should depend on the deformation length scale because of the heterogeneous microscopic structure and the presence of different macroscopic regions and zones in these tissues. Nevertheless, biomechanical studies are rarely accompanied by mapping of tissue composition and structure. To address the problem, we are collaborating with Peter Basser and Emilios Dimitriadis on mapping of cartilage elasticity by force microscopy at length scales appropriate for examining the material properties of the ECM and on combining it with our multimodal imaging technology.
While the ECM plays a key role in normal development and pathology of all tissues, most studies focus on expression of its components rather than its overall organization. Our multimodal imaging technology is helping to close this gap in in vitro studies of tissue sections and cell cultures. To translate these advances into clinical practice, we established a new collaboration with Peter Basser on utilizing the technology to calibrate and test newer methods for noninvasive in vivo ECM studies by the solid state magnetic resonance imaging (MRI) that is being developed in his laboratory. In addition to cartilage, we are working on developing applications of these technology advances to the analysis of placenta pathology within the new Human Placenta Project at NICHD.
Additional Funding
- NICHD Director's Award (2014): Targeting autophagy of misfolded molecules in collagen-related dysplasias
- NICHD Director's Award (2014): New methods to image functional properties of extracellular matrix
- NICHD Director's Human Placenta Award (2014): Extracellular matrix imaging in human placenta
- Mirigian LS, Makareeva E, Leikin S. Pulse-chase analysis of procollagen biosynthesis by azidohomoalanine labeling. Connect Tissue Res 2014;55(5-6):403-410.
- Cabral WA, Perdivara I, Weis M, Terajima M, Blissett AR, Chang W, Perosky JE, Makareeva EN, Mertz EL, Leikin S, Tomer KB, Kozloff KM, Eyre DR, Yamauchi M, Marini JC. Abnormal type I collagen post-translational modification and crosslinking in a cyclophilin B KO mouse model of recessive osteogenesis imperfecta. PLoS Genetics 2014;10:e1004465.
- Barnes AM, Duncan G, Weis M, Paton W, Cabral WA, Mertz EL, Makareeva E, Gambello MJ, Lacbawan FL, Leikin S, Fertala A, Eyre DR, Bale SJ, Marini JC. Kuskokwim syndrome, a recessive congenital contracture disorder, extends the phenotype of FKBP10 mutations. Hum Mutat 2013;34:1279-1288.
- Keupp K, Beleggia F, Kayserili H, Barnes AM, Steiner M, Semler O, Fischer B, Yigit G, Janda CY, Becker J, Breer S, Altunoglu U, Grunhagen J, Krawitz P, Hecht J, Schinke T, Makareeva E, Lausch E, Cankaya T, Caparros-Martin JA, Lapunzina P, Temtamy S, Aglan M, Zabel B, Eysel P, Koerber F, Leikin S, Garcia KC, Netzer C, Schonau E, Ruiz-Perez VL, Mundlos S, Amling M, Kornak U, Marini J, Wollnik B. Mutations in WNT1 cause different forms of bone fragility. Am J Hum Genet 2013;92:565-574.
- Mirigian LS, Makareeva E, Koistinen H, Itkonen O, Sorsa T, Stenman UH, Salo T, Leikin S. Collagen degradation by tumor-associated trypsins. Arch Biochem Biophys 2013;535:111-114.
- Peter Basser, PhD, Program on Pediatric Imaging and Tissue Sciences, NICHD, Bethesda, MD
- S. Patricia Becerra, PhD, Laboratory of Retinal Cell and Molecular Biology, NEI, Bethesda, MD
- Peter H. Byers, MD, University of Washington, Seattle, WA
- Sarah Dallas, PhD, University of Missouri, Kansas City, MO
- Emilios K. Dimitriadis, PhD, Biomedical Engineering & Physical Science Shared Resource Program, NIBIB, Bethesda, MD
- Motomi Enomoto-Iwamoto, DDS, PhD, University of Pennsylvania, Philadelphia, PA
- Antonella Forlino, PhD, Università degli Studi di Pavia, Pavia, Italy
- Kenn Holmbeck, PhD, Matrix Metalloproteinase Section, NIDCR, Bethesda, MD
- Alexei A. Kornyshev, PhD, Imperial College, University of London, London, United Kingdom
- Ken Kozloff, PhD, University of Michigan, Ann Arbor, MI
- Jennifer A. Lippincott-Schwartz, PhD, Cell Biology and Metabolism Program, NICHD, Bethesda, MD
- Joan C. Marini, MD, PhD, Bone and Extracellular Matrix Branch, NICHD, Bethesda, MD
- George Patterson, PhD, Section on Biophotonics, NIBIB, Bethesda, MD
- Charlotte L. Phillips, PhD, University of Missouri, Columbia, MO
- Frank Rauch, MD, Shriners Hospital for Children, Montreal, Canada
- Pamela G. Robey, PhD, Craniofacial and Skeletal Diseases Branch, NIDCR, Bethesda, MD
- Antonio Rossi, PhD, Università degli Studi di Pavia, Pavia, Italy
- Dan L. Sackett, PhD, Program in Physical Biology, NICHD, Bethesda, MD
- Constantine A. Stratakis, MD, DMedSci, Program on Developmental Endocrinology and Genetics, NICHD, Bethesda, MD
For more information, email firstname.lastname@example.com or visit physbiochem.nichd.nih.gov.


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Last name: Sanchez
© Copyright: Name Origin Research www.surnamedb.com 1980 - 2016
Surname ScrollEnjoy this name printed onto our colourful scroll, printed in Olde English script. An ideal gift. View Details.
T.A. Sanchez
my father recently past though i have always been interested in my lineage this has sparked something internal inside befor all the information I have befor me is gone i hope you all have luck finding yours i recently looked on findmypast .com and there tey let you look through the 1940 census but I had to sign up for free but thats all tey let you do but i found my grand parents in chama,Co who past when i was real young
My family. And. I have. A record. Of our family name SANCHEZ. OUR RECORDS. GO BACK. TO1496. My family was brought to Mexico ;along with the GARCIA'S AND THE GAITAN FAMILY. all 3 familys where. Brought. To Mexico by the Marquez. De. Velazquez of Spain ....we still have. The original tiles to a big part of Mexico. City. We have the property tiles to la Magdalena contreras'tacuballa and some. Other. Tows on Mexico city. We. Also have. Record s of beings. The first SANCHEZ. FAMILY. IN MEXICO. OUR RECORD GO BACK. TO 1496...no disrespect. To no one but keep in mind that when. The JESUITAS CAME. TO THE NEW WORLD. THEY BAPTIZED. every one wit. A new. Name. A cristian. Name. Keep. On mind. That you would be baptized. Under the. Name. Of ur master. .
miah gastelum
this is my moms maiden name i i just found out the meaning of this name nd i could noww date this back to the 1850's
Geneva Sanchez
I have family Information that goes all the way back to the 1500's. My family were Jews and came to the new world and settled in what is now New Mexico. We have a very large family here in New Mexico. We have family all over the country and are very close. Wither some of our people where slaves, Jews, royality or just hard workers, were are all now proud Americans
leon sanchez
que buenos somos los sanchez ! viva ! ;D
saludos de valencia
Wilfredo Sanchez


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Huddle Super Bowl predictions
Cyberjag replied to JawnyBlaze's topic in Carolina PanthersPanthers get three TDs and three field goals, Broncos get a TD and three field goals. 30-16 Carolina.
Cyberjag liked a post in a topic: Help my superstitious mind....
CPantherKing liked a post in a topic: A "stat" I want to ignore / continuing to break trends
KB_fan liked a post in a topic: A "stat" I want to ignore / continuing to break trends
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A "stat" I want to ignore / continuing to break trends
Cyberjag replied to KB_fan's topic in Carolina PanthersAll of the other QBs scored all their TDs in the air. Shut that down, shut them down. Let Denver drop a ton in coverage to take away Cam's air attack and see what happens.
Cyberjag liked a post in a topic: Fifty-two Men and a Thousand Faces: Completing the Hero's Journey of the 2015 Carolina Panthers
Eric Davis: Kerry Collins quit on the Panthers and didn't get as much heat
Cyberjag replied to TN05's topic in Carolina PanthersOf course, but as long as you have idiots like Haslam hiring jokers like Ray Farmer, there will be someone who thinks they can fix a drunk and make him work. And FWIW, I think Collins had displayed more pro-level physical talent coming out of Penn State than Manziel had when he came out.
Eric Davis: Kerry Collins quit on the Panthers and didn't get as much heat
Cyberjag replied to TN05's topic in Carolina PanthersDisagree. For exhibit one, let me present Johnny Football...
Eric Davis: Kerry Collins quit on the Panthers and didn't get as much heat
Cyberjag replied to TN05's topic in Carolina PanthersCollins wasn't a racist, but he definitely offended Muhammed when he used the N word with him. Article recounting it here: http://www.nytimes.com/1997/08/24/sports/panthers-collins-finds-himself-tangled-up-in-racial-barbs.html. He was first and foremost a drunk though, and he didn't quit, he was released when he told Capers that his heart wasn't in the game. I would like to think that our current coach would send him to rehab, but Capers had personnel control and basically kicked him off the team. The Saints picked him up and then later that year he got his first DUI. After rehab he got his career back on track.
Newtons2ndLaw liked a post in a topic: What Broncos Fans Are Saying
Nomad82 liked a post in a topic: What Broncos Fans Are Saying
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Wade Phillips
Cyberjag replied to PntherPryd's topic in Carolina PanthersI hear that Phillips plans to contain Cam and double Olsen.
What Broncos Fans Are Saying
Cyberjag replied to Jeremy Igo's topic in Carolina PanthersThey played Alex Smith twice and Andrew Luck, two guys that like to run more than your average QB. Surrendered around 27 ppg.
Jackofalltrades liked a post in a topic: Marty Hurney
Just contributors mentioned here... Before the lockout: Terry Cousin, Jake Delhomme, Ricky Proehl, Greg Favors, Ken Lucas, Marlon McRee, Maake Kemoeatu, Damione Lewis, Tyler Brayton, Keydrick Vincent. After the lockout: Legadu Naanee, Olindo Mare, Haruki Nakamura, Mike Tolbert, Ted Ginn, Jr., Mike Mitchell
It's a pendulum. It will swing back to a moderate dislike instead of foaming hatred, then it will be a sense of gratitude again, and finally it will get to an appropriate resting spot.
Be Honest, How Many of You Were Cam Fans When He Was At Auburn?
Cyberjag replied to RickyManningJr's topic in Carolina PanthersI'm somewhat of an LSU fan, and watched Newton's year at Auburn pretty closely because it seemed like they were on TV every week. I honestly had no idea how well he would do in the pro game, but I trusted the pick. I remember saying on this board at the time that if he could do in the NFL what he did in college, he would revolutionize the game. But of course, I wasn't predicting that. After his first few years, I figured we had a good QB, not a great one, and that this Cam guy had worked out for us after all. After this season, I'm back to the whole "revolutionize the game" idea, and this time I think it's going to happen.
black lives matter planning to disrupt super bowl!! #nojusticenosuperbowl
Cyberjag replied to Sean Payton's Vicodin's topic in The Tinderbox#blackcatsmatter
Heard on MN Radio this morning...
Cyberjag posted a topic in Carolina PanthersI'm in Minnesota (yes, it's #*&@# cold!) and was driving to the client site today listening to the radio. The locals were discussing the playoffs, and whether the Vikings would have fared better against the Panthers in the playoffs than the Cardinals did. They all agreed that they would (homers), but after a few minutes of talking about why one of them said, "but then again, we would have gotten clobbered too." Everyone agreed. They all think we're going to win, and that Cam is a monster who's almost impossible to defend. I've been following this team since the beginning, and have been traveling for work most of my career. This is the first time I can remember us getting so much respect outside the Carolinas, and it's a pretty damned good feeling.
Bucky Brooks: Five part plan for Broncos to beat Panthers
Cyberjag replied to ItsNotGonnaBeAlright's topic in Carolina PanthersTL;DR - Contain Cam, double Olsen
More Important: Remmers vs Miller or Oher vs Ware
Cyberjag replied to AndrewLaskoski's topic in Carolina PanthersI don't think Denver has faced a mobile QB yet this year. Given that, I would expect Cam to call the read option a few times to slow down their rush and keep them guessing. It only works for them when they know the QB is going to throw.
Remember that time people here called to fire RR?
Cyberjag replied to 0115's topic in Carolina PanthersI was one of them. And I remember arguing that it was almost unheard of for a coach to be successful when his first two seasons were losing ones--with all kinds of statistics on my side I'll add. @panther55 was one of the chuckleheads who kept disagreeing with me and pointing to Bellichik as an example of someone who succeeded. And this year it turns out he was right about Shula too. Credit where its due...


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Privacy advocates are voicing concerns about potential changes to the Video Privacy Protection Act (VPPA). The New York Times reports that Netflix is supporting a bill that passed in the House of Representatives last week to amend the VPPA to "allow consumers to give one-time blanket consent online for a company to share their viewing habits continuously." However, privacy advocates including Marc Rotenberg of the Electronic Privacy Information Center are concerned the new legislation will result in users' losing the ability to select how they share specific information. "They are not trying to modernize the law," Rotenberg said. "They are trying to gut the law." (Registration may be required to access this story.)
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PHOTO GALLERY: Prep Football City Jamboree
Alvarez's Ryan Hocog runs against North Salinas on Friday during the city jamboree at Rabobank Stadium in Salinas.
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Artist Genre : Drum & Bass
DnB? IDM? Dubstep? Minimal? Please make up your own mind. It's Electronica and I've been doing it a while.
Influences run deep: Japan, Brian Eno, Depeche Mode, Orbital, Photek, Satie, Yukihiro Takahashi, Robert Fripp, Aphex Twin, Oakenfold, The Prodigy, Ennio Morricone, Autechre, FSOL, Philip Glass. Black Sabbath. Sylvian. The list goes on.
Big thanks for all your comments and support and for listening. That's what makes it all worthwhile. Thank you. "8bitrage"
Artist Links:
8bitrage – Substance – Release Date: 04th June 2012
8Bitrage's debut release through Sub Generation, is truly inspired.
From the outset to the very last note, this has the stamp of pure quality written all over it.
A captivating, perfectly executed track that engages with the spirit.
Atmospheric, yet raw enough to be considered an absolute roller.
A world class track, from a producer that really knows his stuff.
Pure bliss is the order of the day, the main synth lead alone is enough to get the heart pumping, with string elements thrown in that literally swipe you off your feet and transport you to a heavenly state of outer body and outer conscious dream. The force is also string with that all important bass, sweeping it's way into the track and complementing all the other intelligently designed elements. From start to finish this is an epic single, one which EML is very proud and honored to put it's name to, we bring you..8bitrage, don't forget the name.
8BitRage also has tracks available on the following releases
Dark and engaging Dubstep for the real Connoisseur. Featuring 6 tracks created solely for this release, if your planning to DJ over the festive season and you are looking for the perfectly mastered, perfectly produced and executed set of raw,passionate, brilliantly produced tracks to spin, then this is the release for you. 6 extremely powerful tracks that will tear up any dance floor, play it loud, play it often and play it with pride.
Finally it's here, Bass Vulture unleash the first in their 'Cross the Line' Dubstep compilations series, taking the best of the genre from the last few years and compiling it on one exclusive album. Crossing the lines between different Dubstep genres with this unique track listing. Comprising some of the big hitters from the Scene including No. 1 UK artist Rudimental teaming up with Dodge and Fuski for a killer remix of 'Speeding' alongside this you have massive tracks from the likes of Spor, Metrik, RackNruin, Chrispy, Hellfire Machina sitting next to remixes from the likes of Skream, Skism, Chasing Shadows and Funkcase. All of who have been ripping up dance floors and radios across the globe whilst racking up over 14 Million hits on YouTube, and as they say, 14 million people can't be wrong.
Sign up to the 8bitRage mailing list > > http://player.believe.fr/widgetEmail/1/36173/166603/


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Community Forum
Expanding Local Programming on KSKA
KSKA is kicking off September 2009 with a fresh start for many of our local produced programs, including Line One: Your Health Connection, Community Forum and one new program called Addressing Alaskans. During the all Alaska hour, weekdays at 2:00 pm you can look … Read More
Community Forum: the ARC of Anchorage
The ARC of Anchorage has been helping the developmentally disabled, the deaf and others with physical challenges for more than fifty years. Find out how this organization has grown from its start with a group of committed families to it's present day place as a … Read More
Community Forum: Anchorage's Community Councils
Anchorage's community councils are gearing up for fall meetings, after taking a summer break. Find out more about the role of these grass roots citizens panels, why they get the attention of the city's elected officials, and how you can get involved on Community Forum… Read More
Community Forum: Early Learning and Literacy
Alaska schools are getting ready to open later this month, but are all children ready to start learning? Two Anchorage area organizations are helping families prepare the youngest students for early learning and literacy. Find out more about programs aimed at ensuring all Alaska kids … Read More
Community Forum: Anchorage Census
What's going on with the 2010 census? Officials got started early this year in Anchorage on a new plan to find every address possible. How did they do and what's coming up as the next census unfolds? Join us on Community Forum this afternoon … Read More
Community Forum: Talk with KSKA
Programming on public radio is always changing. Faced with the loss of some good shows earlier this year, we took to the air in January and asked you to tell us what you want to hear on KSKA. In March, we incorporated your ideas into … Read More
Community Forum: Alaska Native Young Professionals
Young Alaska Natives are gaining their place in the community, with the help of leadership programs provided by organizations like the Alaska Native Professional Association. Find out more about summer internships and development opportunities for young Native professionals on the next Community Forum, … Read More
Community Forum: Alaska's Treasures
Gold Rush Centennial Photographs 1893 – 1916, Skagway, Alaska. Photo from Alaska State Library, History Collections.
About a thousand important historical archives are estimated to be held by museums, libraries and tribal organizations. The Archives Rescue Corps wants to locate and document these historical treasures, … Read More
Community Forum: Youth Employment in Parks Program
Anchorage teens are joining the effort to make city parks fun and safe places to play. The city's Youth Employment in Parks crew starts work on trails in University Lake Park this week and they will work in the other parks all summer.
Community Forum: PrideFest 2009
Anchorage's PrideFest 2009 kicks off next weekend with a Celebration of Change for the gay, lesbian, transgender and bisexual community. How far have they come in claiming their place in the community, especially in light of the proposed city ordinance regarding discrimination … Read More
Community Forum: Wildfire Mitigation in the Anchorage bowl
Kenai wildfire last month, May 2009. Photo by Casey Kelly, KBBI – Homer.
A wildfire near Homer last month charred 1100 acres and completely destroyed three homes. What are the chances of a calamity like that in Anchorage, and what is the role of homeowners … Read More
Community Forum: Teen Pregnancy Prevention
Teen pregnancies are on the rise again in Alaska, after a two year drop. May is Teen Pregnancy Prevention Month, and, on this week's Community Forum, we'll take a look at programs aimed at preventing unplanned pregnancies among high school students. Join us for … Read More
Community Forum: New Matanuska Susitna Borough Zoning Code
Alaska turns a nifty – fifty this year, and so does the Matanuska Susitna Borough's zoning code. Borough officials say it's time for a re-write, and they want the public to get involved. Join us on the next Community Forum to discuss how you can … Read More
Community Forum: Gardening
Anchorage's chart topping spring temperatures are prompting local gardeners to get out and dig early this year. A move toward growing your own is spurring backyard farmers to experiment with new kinds of produce, while flower lovers may want to find out how rain gardens … Read More
Community Forum: College Graduates Look to the Future
University of Alaska graduates are facing challenging economic times as they prepare for life outside of academia. What are their plans and what kind of innovative ideas are they using in meeting their career goals? Join us for a discussion on college grads and the … Read More
Community Forum: State Crime Lab
State budget restrictions have put construction of a new state crime laboratory on hold. But advocates say the old lab is inefficient and overwhelmed with a backload of cases, and that a new lab could be an effective tool in solving violent crimes. Join us … Read More
Community Forum: Anchorage Runoff Election
Anchorage voters face a showdown for mayor on May 5. Both former city assemblyman Dan Sullivan and former state representative Eric Croft want the job. We've invited both candidates to join us on today's community forum to answer your questions about taxes, the budget and what's next for … Read More
Community Forum: Municipal Parks and Recreation
Last week, city voters turned down a ballot initiative that would have provided about a million dollars for parks. To discuss how the funding rejection will affect the Parks and Recreation Department in Anchorage and the city wide program addressing future improvements to the park … Read More
Community Forum: Muni Ballot Propositions 3 – 8
Everyone's watching their dollars these days, especially Anchorage's Budget Advisory Committee. The committee is working on a strategy to use millions in federal funding unrelated to the stimulus package. How will this help our city, and how will the fate of bond proposals on the … Read More
Community Forum: Propositions 1 and 2, School Bonds
Anchorage voters will be asked to decide on two bonds for school additions and renovations when they go to the polls on April 7th. Join us for an in depth look at Propositions one and two today on Community Forum.
LINKS MENTIONED:Read More