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, Volume 27, Issue 3, pp 761-767
First online:
Revision of failed traditional fundoplication using EsophyX® transoral fundoplication
- Reginald C. W. BellAffiliated withSwedish Medical Center and SurgOne P.C. Email author
- , Rachel J. HuffordAffiliated withSwedish Medical Center and SurgOne P.C.
- , Jacqueline FearonAffiliated withSwedish Medical Center and SurgOne P.C.
- , Katherine D. FreemanAffiliated withSwedish Medical Center and SurgOne P.C.
Laparoscopic revision of failed traditional fundoplication is difficult and involves risk of gastric, esophageal, and vagal nerve injury that is higher than that of the primary fundoplication. This study assessed feasibility and clinical outcomes of the transoral approach to revision of loose Nissen.
Between November 2009 and August 2011, a total of 11 patients underwent transoral repair as opposed to 70 patients who underwent laparoscopic or open revision of a failed fundoplication. Subjective and objective outcomes were evaluated with the GERD health-related quality of life (GERD-HRQL) questionnaire and the reflux symptom index (RSI) questionnaire and ambulatory pH testing. The competency of the new antireflux barrier was evaluated by endoscopy. Wilcoxon signed-rank test was used to compare pre- and postoperative variables.
All 11 patients evidenced loosening of the Nissen fundoplication without evidence of hiatal failure. Mean age was 57 years, BMI was 25.1 kg/m2, and 4 of 11 (36 %) were female. Indications for operation were abnormal pH-metry off PPIs (6), impedance/pH on PPIs (3), esophagitis (1), and evidence of free reflux on barium swallow (1). One patient developed a postoperative bleed requiring transfusion. Two patients had laparoscopic revision at 6 and 8 months after the transoral procedure. At a median follow-up of 14 (range = 6–28) months, 8/10 patients reported resolution of their primary symptoms. Eight patients had pH testing off PPIs both pre- and postoperatively; median % time with pH <4 improved by dropping from 8.1 % (21–4.8 %) to 0.6 % (13.4–0.01 %) (p = 0.008). Esophageal acid exposure normalized in 5/6 patients. Mean GERD-HRQL score improved significantly by dropping from 28.6 (10.6) preoperatively to 6.7 (6.1) post-TIF (p = 0.016). Mean RSI score improved more than 50 % in 5/7 patients.
Transoral revision of failed traditional fundoplication without herniation is technically feasible. It results in symptomatic and objective improvement of GERD without the risks of laparoscopic dissection for a majority of patients.
KeywordsFundoplication EsophyX® Gastroesophageal reflux Laparoscopy Nissen fundoplication TIF
Reference tools
- Title
- Revision of failed traditional fundoplication using EsophyX® transoral fundoplication
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
- Journal
Surgical Endoscopy
Volume 27, Issue 3 , pp 761-767
- Cover Date
- 2013-03
- 10.1007/s00464-012-2542-7
- Print ISSN
- 0930-2794
- Online ISSN
- 1432-2218
- Publisher
- Springer-Verlag
- Additional Links
- Topics
- Keywords
- Fundoplication
- EsophyX®
- Gastroesophageal reflux
- Laparoscopy
- Nissen fundoplication
- Industry Sectors
- Authors
- Reginald C. W. Bell (1)
- Rachel J. Hufford (1)
- Jacqueline Fearon (1)
- Katherine D. Freeman (1)
- Author Affiliations
- 1. Swedish Medical Center and SurgOne P.C., 401 W Hampden Place, Suite 230, Englewood, CO, 80110, USA


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Governance and Economic Management Assistance Program
|This article does not cite any sources. (October 2008)
The Governance and Economic Management Assistance Program (GEMAP) is an effort, started September 2005, by the Liberian government and the international community, via the International Contact Group on Liberia (ICGL) to reshape the fundamentally broken system of governance that contributed to 23 years of conflict in Liberia.
GEMAP's effectiveness is a point of contention as there is evidence to support both sides. Proponents argue that the nature of the program, with its 'intrusive' financial controls and arbitration body for resolving disputes with the executive directly, sent a strong message to the Liberian elite that the corruption of the past would no longer be tolerated. In fact, there is considerable anecdotal evidence that GEMAP introduced an element of accountability into the bureaucracy that hadn't existed for over a generation. In this sense, GEMAP has accomplished its goal of modifying the conversation about corruption to a direction of reform. However, the Johnson-Sirleaf government has also taken a pro-reform platform, so responsibility for this cultural (if not practical,) shift may never be known.
Critics argue that the program has been ineffective in combating corruption, and that the situation is as bad or worse than in previous administrations. They note that rampant corruption still persists in GEMAP institutions like the National Port Authority, and recent criticisms about the national budget cast doubt on the transparency of revenue intake and outflows. Others have renewed protests against GEMAP, claiming that it was developed in the context of the highly corrupt transitional government, and the responsibility demonstrated by the Sirleaf government demands a reduction of the oversight.
GEMAP was never designed to 'fix' the corruption problem in Liberia. Only a generation of law enforcement, governance reform, technical assistance and education can hope to tackle that monumental problem. GEMAP was designed as economic 'triage' for a hemorrhaging (= 'bleeding') country, and in that narrow view, it can be considered a success, partly due to the 50% year-to-year increases in government revenue, the government's review of contracts and concessions (and renegotiation of the Mittal and Firestone contracts), reforms in the timber and diamond sectors, and the general high-level commitment to improved financial controls.
GEMAP is under consideration by both academics and policy makers as a tool for other post-conflict states. With greater awareness by donors that they function as 'investors' in developing countries, it is likely that additional GEMAP-like programs will be created in the future in order to provide the 'investors' some measure of reassurance that their 'partners' are in fact spending their money, as well as the donors' money, responsibly and with accountability.


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|Review: LeapPad Explorer
Friday, 14 October 2011 11:42
The box proclaims that it is meant for the 4- to 9-year old set, but from the moment my just-turned-three-years old niece got her hands on it, she was completely enchanted and absorbed by it.
LeapFrog's tablet PC offering for kiddies, the LeapPad Explorer, is friendly right from the get-go. Once you have inserted the four AA batteries – which are not included – your child can start playing right out of the box. That is because the LeapPad does have some apps, such as the Pet Writing, pre-installed. Simply elect to set up the device later and proceed to the home screen, from where your little user can begin by setting up a profile and start playing, take photos and even shoot videos with the built-in camera, video recorder and microphone.
The LeapPad, which is now available to consumers in South Africa just in time for the holiday shopping season, is a tablet that aims to 'edutain' (meaning entertain them while simultaneously educating them on the sly) kids via interactive games and apps that will teach them anything from vocabulary, reading, writing, to helping them master life skills (such as how to brush their teeth) and fine motor skill development. The device is light-weight and small to be comfortably carried around and handled by little hands, yet sturdy enough to withstand rough handling and drops.
The LeapPad has two GB of internal storage, an accelerometer that allows players to tilt the device to direct some action during games (such as making bugs move in a certain direction); a five inch, colour touchscreen with 480 x 272 resolution that can work in both portrait and landscape mode; a stylus – with the folks at LeapFrong having the wisdom and foresight of including a spare – an install CD containing the Story Studio and Art Studio apps, plus a free app download; and a USB cable.
It has volume control buttons (a larger one indicating volume up) a headphone socket, navigational buttons for up, down, left and right and a Home button for easy, intuitive navigation. Our only beef with the controls is that LeapFrog did away with the Help/Assist button that is on the Leapster Explorer's handheld gaming console.
However, a nice touch is the fact that Leapster Explorer game cartridges and apps are cross compatible with the LeapPad, so no need to shell out the average of R250 for new games if your kid has had a Leapster.
It is genuinely so easy to use, my sister only had to show my niece once before she was deftly handling the device on her own, playing games and creating art. The games and apps are cute and parents can monitor their learning progress. Exhibitionis parents can share some of their little prodigies' works of art and stories online via Facebook and e-mail.
A definite drawback is the fact that it contains no built-in battery that can be recharged via USB. The four AA batteries were drained after two days of non-continuous play. On the upside, this is good for people who are off the beaten track, where electricity might not be readily available, or for those camping trips and car rides. Just don't run out of batteries! And invest in rechargeables, otherwise it could cost you…
Rating out of ten
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Course in financial literacy are scheduled for sites in Fulton and Oswego.
According to a recent national report, low basic skills in literacy and numbers are more common now in the United States than on average across participating countries. One in five adults in the U.S. have low literacy skills and nearly a third have weak number skills.


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60D 85mm 1.8 worth it if you have the 50mm1.8?
Started May 13, 2013 | Discussions thread
Shop cameras & lenses ▾
Forum Member • Posts: 58
Since you mentioned portraits the 85mm f/1.8 will be better for this type of photography... the 85mm will give you a better BOKEH and at the same time will give you lesser distortion specially head shots. Although you will be shooting in crop you are not changing the characteristics of the lens you are only "cropping" or lessening the field of view.
And yes it is worth keeping the 50mm as well but if you can upgrade to a better 50mm like the 1.4 or the sigma... much better imho.
Here is a funny video explaining what I am saying. Just bear with Kai the Asian guy.
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What is the XT1 UK cashback offer on the superzoom?
Started Mar 7, 2014 | Discussions thread
Shop cameras & lenses ▾
alun wrote:
Some UK dealers, such as Castle Cameras, are advertising that their XT-1 bodies come with a voucher giving £250 off the price of the forthcoming 18-135mm zoom.
http://www.castlecameras.co.uk/fujifilm-x-t1-body-only-- hide signature --
This is not specific to castle camera. It is UK wide, confirmed by Fuji UK when someone asked them at the recent photography show.
-- hide signature --
Ket Sang Tai
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ketsang's gear list:ketsang's gear list
Fujifilm X100S Fujifilm X-E1 Fujifilm XF 35mm F1.4 R Fujifilm XF 60mm F2.4 R Macro Fujifilm XF 14mm F2.8 R +2 more
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Warrior Ethos
What is it? The Warrior Ethos is a set of principles by which every Soldier lives. In a broader sense, the Warrior Ethos is a way of life that applies to our personal and professional lives as well. They define who we are and who we aspire to become.
What has the Army done? The Army has worked to instill the Warrior Ethos in all our Soldiers by the way we train, live, and fight. Every Soldier that has entered into the Army Family has been taught that the Warrior Ethos, rooted in Army values, and founded on the premise that service to our Nation is an honor and a responsibility that requires self-sacrifice. The very notion of SERVICE is founded on the premise that you give more than you get. This ethos has enabled our Soldiers to endure the rigors of combat and distinguish our Army on the battlefield by the character of our service.
What efforts does the Army plan to continue in the future? As the Army continues to grow and fight the long war against terror, the principles outlined in the Warrior Ethos will continue and be passed on to individuals ready and willing for warrior service. Bound to each other by integrity and trust, the young Americans we welcome to our ranks will learn that in the Army, every Soldier is a leader, responsible for what happens in his or her presence regardless of rank. They will value learning and adaptability at every level, particularly as it contributes to initiative: creating situations for an adversary, rather than reacting to them. They will learn that the Army's culture is one of selfless service, a warrior culture rather than a corporate one. As such, it is not important who gets the credit, either within the Army or within the joint team; what's important is that the Nation is served. To continue reading this topic in its entirety, click here.
- This topic was taken directly from the 2007 Army Posture Statement.
Army Safety Awards Reinforce Accident Prevention
Army Safe is Army Strong! Below are some tools for encouraging recognition to organizations and individuals that remain vigilant in keeping the Army Strong via recognition through the Army Safety Program.
*Refer to AR 385-10 and DA PAM 385-10*
- Army Level Safety Awards
- DASAF Awards
- U.S. Army Broken Wing Award
- Sergeant Major of the Army Superior Soldier Safety Award
*Refer to Local Command Guidance*
- Army Accident Prevention Award of Accomplishment
- United States Army Aircrew Member Safety Award
- Unit Impact Awards
- Certificate of Achievements
For information on these awards and guidance in the nomination process, visit the U.S. Army Combat Readiness/Safety Center Web site or contact email@example.com.


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Intelligence Online reports that the Russian oligarch Oleg Deripaska has hired an advisory firm with close ties to Hillary Clinton to help him get a visa to enter the United States. As I've previously reported here, Deripaska has been barred from this country over concerns that he has ties to organized crime.
Intelligence Online says (warning: story is firewall protected) that Deripaska — who previously employed beltway lobbyists close to John McCain, including his former campaign manager Rick Davis — has retained the Endeavor Group, which, the newsletter says, "specializes in providing services to billionaire and show business personalities."
Endeavor's partners include Lorrie McHugh-Wytkind, formerly "Communications Director for Senator Hillary Rodham Clinton and Deputy Press Secretary for Media Affairs and Operations for President Bill Clinton," and its advisers include Bruce Babbitt, Secretary of the Interior under Bill Clinton and a Hillary supporter during the Democratic presidential primaries.
Update: Adam Waldman, founder and president of the Endeavor Group, writes to say that his firm doesn't lobby, so I've changed this post to reflect that. The firm's website says, "The Endeavor Group represents a select group of entrepreneurial, high net worth individuals. The firm was founded in 2001 to provide cross-disciplinary advisory and execution services in support of the complex business and philanthropic initiatives of our clients."
Waldman also said that Lorrie McHugh-Wytkind has been a strategic communications partner (which means consultant) to my firm on two very specific philanthropic initiatives, dealing with (i) Malaria and (ii) Neglected Tropical Diseases. She has never had any involvement, nor would she, in our work with Oleg Deripaska or any other client matters outside of these two projects. Second, Bruce Babbitt who is the Chairman of the World Wildlife Fund and serves on our informal advisory board, never has had any involvement with our client work."
I don't think that changes the thrust of the post or of the Intelligence Online piece, though. Deripaska did hire a firm with ties to Hillary Clinton, which can't be a bad thing nowadays.
More from Ken Silverstein:
Commentary — November 17, 2015, 6:41 pm
The Clintons' so-called charitable enterprise has served as a vehicle to launder money and to enrich family friends.
From the November 2013 issue
Perspective — October 23, 2013, 8:00 am
How pro-oil Louisiana politicians have shaped American environmental policy
Estimated percentage of New Hampshire's bat population that died in 2010:
New Hampshire Fish and Game Department (Concord, N.H.)
A horticulturalist in Florida announced a new low-carb potato.
In Peru, a 51-year-old activist became the first former sex worker to run for the national legislature. "I'm going to put order," she said, "in that big brothel which is Congress."
Subscribe to the Weekly Review newsletter. Don't worry, we won't sell your email address!
"Civilization masks us with a screen, from ourselves and from one another, with thin depth of unreality. We habitually live — do we not? — in a world self-created, half established, of false values arbitrarily upheld, largely inspired by misconception, misapprehension, wrong perspective, and defective proportion, misapplication."


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The Wonderful Mr. Snow
Monday, January 9, 2006
I am extremely sad about the passing of Jack Snow. With that in mind, this edition of notes will have little to do with football or anything going on with the team. We can get to that later. In the meantime, Id like to share a little bit of what Jack Snow was like and the type of person he was. First and foremost, my prayers and thoughts go out to his family. Also, I would like to make tomorrow's edition of the mailbag a tribute to Jack Snow. For those of you with a great story to tell about Mr. Snow either as a player, a broadcaster or an encounter somewhere, please send it along and I will post it in the mailbag.
The first time I ever met Jack Snow was in training camp before the 2004 season. I have to admit, it was a little intimidating. Here was this guy who had played 11 seasons for the Rams, appeared on the television show Bewitched and was even in the movie Heaven Can Wait. When I introduced myself to him, I made the first mistake that someone who is younger and doesnt know him can make. I said Nice to meet you, Jack. I was promptly informed that I should henceforth refer to him as Mr. Snow. For each time I called him Jack, he would grow continuously irritated with me. Not wanting to get off on the wrong foot with one of the great sources of information about not only the Rams, but also football in general, I made it a point to remember to always address him as Mr. Snow. To some, that might sound like he is being arrogant, but as he told me, he was always taught to respect his elders and I should too. The more I remembered to address him correctly and the more I got to know him, I began to see that Mr. Snow was one of the funniest, most genuine people around. He even told me that there would come a day where I would be able to call him Jack. Of course, he would let me know when that day came. I saw him on multiple occasions stick up for people who couldnt stick up for themselves. He was always ready with some sort of sarcastic comment or witty retort at a moments notice. But at the end of the day, you always knew he was just having fun. If Mr. Snow didnt make fun of you or have a joke for you, it probably meant he didnt like you much. Needless to say, I was on the receiving end of a number of those jokes, but I learned a lot about the history of the organization from him even if I refused to root for Notre Dame as he often tried to get me to do.
As the color analyst for the Rams, many criticized him for being a homer for the team. But thats because he was part of the team. A big part. Anyone who devotes that much time and energy to an organization will inherently have a certain amount of loyalty. Being a Ram was who Mr. Snow was. He loved this organization and he loved everything about being a part of the broadcasts. As recently as the weekend of the Houston game on Nov. 27, Mr. Snow seemed to be in good condition. He became sick soon before the buses left to go to the airport that day. He was taken to the emergency room for a staph infection soon before the buses were to leave. But, always the tough guy, Mr. Snow made it to the airport in time to get on the plane. It was a fashionably late entrance that only he could pull off. But when he arrived in Houston, he was worse for the wear and was unable to broadcast the game. As much pain as he was in then, it pained him just as much to not be there to watch the Rams play as he had been so many times before.
I wasnt alive to have the pleasure of watching Mr. Snow play football. But I know the amount of time and work he put into his job as the color analyst for the team. Im certain that he had the same type of drive and desire as a player. For all he accomplished on a football field, Mr. Snow always loved to tell me about his appearance in Heaven Can Wait. In fact, he told me of his role that first day I met him. He even told me that it was the only movie set that Warren Beatty has been on where he was the second-best looking guy there. I, of course, laughed, but was quickly corrected as he pointed out that he was being serious. Perhaps my favorite Mr. Snow anecdote was the story that was retold in former Rams Public Relations Director Rick Smiths book. During a game, apparently Mr. Snow caught a pass near the sidelines and couldnt slow his momentum enough to keep from running over actor Telly Savalas. According to the book, Mr. Snow returned to the huddle and blurted out, "I think I just killed Kojak."
Many times in life, good people are taken away from us too soon. Unfortunately, I didnt get to know Mr. Snow long enough to call him Jack. I guess in this case, Heaven just couldnt wait.


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May 14, 2015 Bob Buskirk All News, Hardware News 1
Now with the higher-end GeForce GTX cards being bundled with Watcher 3: Wild Hunt and Batman: Arkham Knight there are some games that you can now get for free with select Radeon graphics cards. These games include DiRT Rally and Grand Theft Auto V and are available exclusively through Newegg.com.
Jan 18, 2012 Bob Buskirk Articles, Events 0
Rosewill is primarily known for its affordable chassis, power supplies, and networking products. We ventured to the company's suite to check out the new Blackhawk chassis, capable of housing an HPTX motherboard, and several other chassis, new and old. We also check out the company's new laptop cooling devices, 80PLUS certified power supplies, and new 300 Mbps Wireless N routers and adapters. Listen in on ThinkComputers' Colin Dean in this video overview of these products from CES 2012.
Feb 09, 2016 0
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Feb 04, 2016 4
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Feb 01, 2016 0


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Andy Murray has a big fan in Andre Agassi
/ Sport
Former world No.1 Andre Agassi believes Andy Murray is ready to dominate men's tennis over the next 12 months.
Seven months ago, Agassi was one of many former players and pundits who believed Murray was a victim of his time and that in any other era he would have won "multiple Grand Slams".
Murray never allowed himself to think about what might have been. Instead, he picked himself up, won the Olympics and then the US Open to break his Grand Slam duck in grand style.
Four months on, the consensus seems to be that Murray should now kick on, that his confidence will lead to more major success, and Agassi is now a believer.
"The way he got across the line in New York will have a huge impact on him because he had to step up and take it,'' he said.
''He couldn't just wait and watch somebody implode. He had to step up in that fifth set and step up against the biggest player on the biggest stage and take it, and he did.
"If his evolution is anything like mine, that was the real light switch that went off for me. I realised that I can't hope for somebody to lose. I have to want this enough to go after it. I think once that clicks in for him, you'll see him playing to their standard throughout the year and for a few years to come.''
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The American has long been an admirer of the Scot's ability to unsettle opponents and take them out of their comfort zone.
But it is the world No.3's increased willingness to take the attack to his opponents, even when under immense pressure, which Agassi feels could see him dominate in 2013.
''This is Murray's year to really break through,'' he said. "He's come to understand what he needs to do out there.
"He has so many defensive skills that he does run the risk of falling into the temptation of being passive on the court. I think that can get him past everybody but not the two greatest players to ever play – Roger Federer and Rafa Nadal, not to mention Novak Djokovic, who is now starting to be part of that equation.''
Murray says he will not know how he will feel in Melbourne until he steps onto court for his first match tomorrow against Dutchman Robin Haase.
He is more relaxed than ever going into a slam, but is confident he will not allow any complacency to creep in; just because he won the US Open does not mean he is guaranteed to play well here.
Agassi expects Murray to increase his Grand Slam tally sooner rather than later.
"I believe he has very specific goals and objectives," Agassi said.
"He believes he can put a lot of numbers on the board.''
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Polk Audio db1222
Ported enclosure with two 12" db Series subwoofers
Item #: 107DB1222
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We offer vehicle-specific installation instructions, dash kits, wiring harnesses, and speaker accessories at deeply discounted prices with car stereo and speaker purchases. Available for most vehicles.Learn more
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Item #: 107DB1222
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Your price: $229.99 Earn up to 230 Rewards points
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Leave it to Polk Audio to come up with a no-nonsense sub box that'll fill up your vehicle with bass without emptying your wallet. The db1222 enclosure combines a pair of 12" db Series subwoofers with a rigorously engineered cabinet for chest-thumping low end from your trunk or cargo area.
Polk uses extensive laser testing to optimize the internal structure of the db Series subwoofer to deliver fluid, powerful bass. The polypropylene cone and Santoprene surround hold up against harsh environmental effects caused by sun, moisture, and intense temperature changes, while the beefy frame ensures these subs can stand up to a pounding.
The db1222's streamlined enclosure features advanced Power Port technology for high speaker efficiency with reduced distortion. The silver ABS front panels get a facelift over previous the previous Polk db double 12" enclosure, but the box still features the same internal bracing used in their stellar home speakers to reduce resonance. Eye-catching grilles and tough black carpet complete the package. Just add an amplifier and wiring, and you've got one heck of a system.
An enclosed subwoofer is a box with a subwoofer already installed. The advantage to buying an enclosed sub is that the manufacturer made the sub, then designed and built the box as a perfect match, so you'll get the best possible performance. Every enclosed sub has a maximum RMS power handling rating, so pair it with an amp with a similar RMS power rating to get the best performance.
I bought these about a month ago, and they were far from my fist set of 12" subs. I had a 1200 watt Infinity amp with two dual 12" infinity subs previously, and they destroyed my Durango. But I'm running my Polks on a Punch p200 amp, which peaks at like 820 watts, and these subs hit just as hard as those Infinity's with 1200 watts. and the Punch amp is'nt turned up all the way. I love the way they look, the box is solid as they come, and the sound quality is awesome. I have them in an 07 Kia optima and it shakes the block. Only subs I had that hit harder was a single 13" JL W7. And it cost $1000+ in a box. For the price, these are the way to go.
Pros: Frequency range, hi and low bass quality, appearance
Cons: Heavy!!
Had these in my car for over a year and thought they sounded great. Then I blew one of the subs and replaced them both with Pioneer TS-W3002 subs and it was like night and day. The pioneers were musically superior in every way in the same box. For the price I paid the polks are a great value but definitely more of an SPL type sub, not for sound quality. The box is really solid, looks great, and holds up great even with the new subs in it.
Pros: Price, Looks great, Solid build
Cons: Sound quality, low RMS power rating
Purchased these a few weeks ago with one of my summer work checks. They hit super hard, they sound great, and vibrate the entire truck and anything around it. I pulled into my gfs house and her sister said to turn it down next time because i was vibrating the house. 5 stars.
I bought the db1222 about 3 or 4 years ago when I was in high school, powered by a Kenwood 1700W Max MonoBlock amp, these are ridiculously loud. Without the rear window rolled down on my Toyota 4Runner it sounds like it is going to vibrate to pieces, and that is not because I haven't tried eliminating rattle sources.
Many of my friends have systems and have spent much more, but mine is still the loudest. Friends who have systems in their cars ask me to turn it down when they ride with me. Girls in the backseat say they feel like they're getting their hair blow-dried. The one time I got a ticket for an "unlawful noise making device" the officer said his car was shaking while he was several cars back at a red light.
When my parents borrowed my vehicle they were driving through the neighborhood listening to Margaritaville, they probably didn't have it past half- volume because they're old, but it was enough to get a neighbor from several blocks down to walk to my house and complain to my parents about me driving through the neighborhood blasting it.
My db1222 is the previous generation with a slightly different design and the previous gen subs. Well after several years of thumping on full volume to bass heavy songs, one of the subs finally blew. I will be replacing both of the subs with the newer subs that come in the current db1222, hopefully for several more years of ground-shaking.
This is the first system that I have owned but I have heard plenty of them and none of them come even close to comparing how these subs sound! If I could give it above 5 stars then I definitely would. These have so much bass that it will honestly blur your vision while your drivin if you put it on the right song, but yet at the same time the sq is so clear that its hard to believe that you could get these at such a low price. Everybody that hears them is tellin me I have to enter a competetion and that there is no doubt that these would place 1st. The bass from these was the most suprising for me though, I figured they would hit hard but once i actually heard them it seriously took my breath away, i couldnt believe how hard these hit! It rattles everything in my car including me, its done took my mirror off. I love it cause people just listen for me now instead of watching for me. There is so much more i could say but not enough room to write it, all in all it would be stupid to pass on these subs, they are amazing!.. and also i have a 1800 watt kenwood amp powering them and it couldnt sound better
When one of my aging 12" L7s (2001) had a coil wire break I searched high and low for a replacement and settled on upgrading to a pair of modern L5s to keep the bass fiend in me content but I didn't want to spend the money on a new pair of them.
I spotted these and given the more than kind return policy I opted to give it a try.
I prompty hooked these up to an alpine mrp m500 and I am actually shocked at how decent they sound. I need to give them some time to loosen up a bit, but they are pretty loud and for the price they are reasonably clean. My old L7s in 1.5cu' sealed had better SQ, but they didn't hit anywhere near as hard as these do, and the boxes alone cost more for the L7s.
At the retail price I don't know if I could give these as rave of a review but I LOVE THEM.
The only downside for me is the size, but I bolted a pair of handles on them so I can yank them out if I need to.
I have these subs hooked up to a 450 Kicker and they sound great! I know they are only getting about half the power they can push but they still sound great. In the first few days with my newly installed subs I had to buy a new battery and the individual letters that spell Subaru on the back started to fall out. I cannot wait till I can add a new amp that can put these beasts to the test.
i use to have these subs..i had them hooked up to a 700watt amp and they hit really hard. they rattled my trunk so hard the trunk wouldnt close correctly and the latch got messed up and unfortunately water got inside the trunk so they didnt work anymore. but again i would recommend them
I have had these speakers for over 2 years now. they are hooked up to a 1600 watt amp ran through a cap, eq, and crossover. I have won best in class 2 years in a row at our annual car show. Trust me these are worth every penny! Just when I didnt think they could get better, the crossover made such a tremendous difference I couldnt believe how much bass I get out of these things.
These subs are amazing! I have an Alpine 800 watt amp hooked up and these things hit hard.
I have seen person after person review these subwoofers as "crazy bass" and all I can say is they were completely right. I've had these for about a year now and they are the best subwoofers I have owned hands down. Besides strong bass, the range of these speakers is unmatched(hits the highs and the lows nicely). I have them wired to a 1500 watt amp with my gain about halfway. I listen to a wide range of music (but mostly rap) and these speakers satisfy every genre. I have yet to hear a lick of distortion even at extremely loud volumes. Dont think twice. Buy this enclosure. You WILL be satisfied.
This subs hit hard. I love them. I like everything about them. You can hear me bumping from half a mile away. No joke!! The only bad thing is I only bump it for about five minutes, and then the cops come. The only weaknees are weak neighbors. Other than that good subs.
I just purchased these subs... all I can say is WOW!!! rediculice BASS!!!! I only have it hooked up to a rockford fosgate p200.. yes i know it is a 200 watt amp but o my good. it is crazy... i do have a 1000 watt sitting in the closet but im a little afraid to hook it up.. Cazy sub but i would recomend them
These subs definitely pound. I have them hooked up to a kicker ZX750.1
and they sound great. The only problem is that polk didnt make the wires
that are on the sub itself (the ones that go from the voice coil to the
connection) long enough and every pair that ive had after about 2 or 3
monthes ive had to send them back because on of those wires on one of
the subs comes off and they stop working. When the subs hit and expand
out they pull on the wires and they eventually come undone. Bottom Line:
they sound great but not worth the hassle.
These subs are amazing. i put them in my 2004 forester and they are crazy. i have them hooked up to a 750.1 kicker amp too, and they hit so hard. i turn them all the way up and i can't even hear the lyrics anymore, even with custom speakers powered by an amp. these are definately worth the money, and don't skimp on the istalation get it done right. the looks you get when driving past people with these cranked are priceless. they provide a nice rang as well, so don't be worried about not getting the highs.
I have these hooked up to a kicker 750.1(1000watt amp) in my tahoe. I bought these subs knowing polk was a good name brand, and didnt know what I got myself into haha. They hit hard, but mostly they have a ridiculous amount of depth to them for 12's. I get looks wherever i go, even though with the doors closed they are relatively quiet, probly cause of my ride. Buy these if your looking for a good set of 12's.
THE BEST PART is i havnt blown them with the amp dials a little below half, and believe me, I've cranked them!
I just put this in my explorer running 800rms watts to it and it bumps hard.
If I turn it all the way up it knocks all the mirrors loose, its just loud.
So yeah it hits pretty hard and can handle more rms than it says
I got 2 1000 watt rms pumping through each speaker and these things blow my head off!
Deffintly worth the money, wont let you down at all!
but they're pretty heavy
|Woofer Size (inches)
|12 x 2
|Woofer Material
|Enclosure Type
|Pieces in System
|Width (inches)
|Height (inches)
|Depth (inches)
|Second Depth (inches)
|Connector Type
|Spring Posts
|Frequency Response
|27-200 Hz
|Power Range (Watts RMS)
|Maximum Wattage
|103 dB
|2 ohms
|Parts Warranty
|1 Year
|Labor Warranty
|1 Year
Overview: The Polk Audio DB1222 is a bass-reflex enclosure loaded with two 12" Polk db subwoofers.
Enclosure: The DB1222 features a vented-enclosure covered in high-grade black carpet and features an ABS front-baffle and two ABS grilles.
Dual Woofers: The DB1222 comes loaded with two 12-inch, 4-ohm Polk Audio db subwoofers wired in parallel for a 2-ohm mono load the the enclosure's speaker terminals.
At Crutchfield, you'll get detailed, accurate information that's hard to find elsewhere. That's because we have our own in-house Product Research team. They verify what's in the box, check the owner's manual, and record dimensions, features and specs. We stay on top of new products and technologies to help people make informed choices.
going by the specs on this product it seems like the best deal for your money. I have owned a set of polk audio home speakers and they are great sound quality with no distortion. these subs have a db rating pf 103 at 2ohm, the others that are available have a rating of 98 or less. so I am giving these a try and I'm hoping they will give my car system the kick it needs. ill have to wait and see and keep my fingers crossed. wish me luck!! [ Carey Dec 11, 2015 ]


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What does your username mean?A lot of the time I read people's username and wonder what they mean, sometimes it tells of their age, their gender and interests. If you get someone called MsNaruto1994 then you can probably tell its a 18 years old Naruto fan girl. However if you get someone's username like Kill982Fuk138, then you just gota wonder and becareful with your conversation with them because they may be psychologically unstable. And I think thats what I wanna understand, what is the history behind everyone's username? Why is Chancake a cake? Why is k-hots so hot? Why is Dragonith a dragon? Why is batwa a bat? Why does Lunaoverthecow have Lucin in her name but I have never ever seen Lucin? When is EXP282 gonna get more EXP? Why is Cry-to-the-wind crying... to the wind? Why is PancakeLament so yummy? Why is fightingleaf fighting a piece of leaf? Why is hummingbird96 a bird? Why is sshoes a storn and not a storm? Why is M-13Beta still in Beta mode? WhWhat does your username mean? by Ry-Spirit More Like This
Deviant portraiture free of charge UPDATE: Deviant portraiture will be running on monthly basis from now on. Those of you that wish for a portrait by me AND have the 5 critiques rule accomplished, please also COMMENT on this journal, since some favs are 9 months old (:Deviant portraiture free of charge by jane-beata More Like This
Music and art, art and musicI was really intrigued to learn that Cameron Crow said that he was listening to the music of Jonsi Por Birgisson (lead singer of Sigur Ros and solo artist under the name "Jonsi") while creating the movie "We Bought A Zoo" for which Jonsi has contributed the soundtrack.Music and art, art and music by muzzy500 More Like This
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Are you Jean-Olivier Contreres?Claim your profile
Publications (14)120.03 Total impact
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ABSTRACT: An interaction between tumor cells and the microenvironment, as well as the development of angiogenesis, are required to form liver metastases (LMs). Immunofluorescence detection of α-smooth muscle actin, desmin, Ki67, laminin, and CD31 was used to analyze the kinetics of tumor angiogenesis determinants, especially the contribution of hepatic stellate cells (HSCs) to angiogenesis in hepatic metastasis produced by intrasplenically injected LS174 colorectal cancer cells. Immunostaining was performed at various times (days 9, 14, 28, and 39). At the earliest stage, micrometastases consisted of proliferating cancer cells, a well-organized network of activated HSCs and laminin deposits. No vascular network was observed. As the LMs grew in size, an organized vascular network appeared; the laminin network colocalized with CD31 immunostaining. At the later stages, all the immunostained markers became peripheral as a central necrosis developed. Purified activated HSCs isolated from transgenic mice livers developing hepatocellular carcinoma secreted laminin and showed enhanced human umbilical vein EC network formation in a Matrigel assay. In a coinjection LM experiment, activated HSCs enhanced the metastatic process. Moreover, colorectal LMs from six patients were analyzed, and a pattern of marker distribution similar to the coinjection experiment was found in human LMs. For the first time, our results show that HSCs play a crucial role in organizing and accelerating the progression of metastasis in modulating the prometastatic niche, interacting with colorectal cancer cell recruitment, and the organization of angiogenesis during colorectal LM development. Therefore, HSCs may be an early therapeutic target in colorectal cancer therapies. Copyright © 2014 Elsevier Inc. All rights reserved.
Article: Abstract 19: PlGF/VEGFR-1 dependent activation of the Dll4-Notch4/Ephrin B2 cascade contributes to liver vessel anomalies in hepatocellular carcinoma
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ABSTRACT: Tumor angiogenesis is closely associated with clinical staging and has been proposed to correlate with clinical response in terms of subsequent metastases following primary resection. Netrin-4 (NT-4) regulates angiogenic responses. Therefore, we sought to examine the effects of NT-4 on the primary tumor growth of colon cancer cells, liver and lung metastases of colon cancer cells, and responses following primary tumor resection. We used 3 different mouse models of orthotopic primary tumor and liver and lung metastases, comparing 2 human colon cancer cells lines: wild-type (low expression of NT-4) and NT-4 (overexpression of NT-4) LS174 cells. NT-4 overexpression inhibited the primary tumor growth of colorectal LS174 xenografts in nude mice (144.3±12.9 vs. 62.4±4.5 mm3; p<0.0001) as well as its related local and systemic recurrence (38 vs. 0%; p<0.01). NT-4 overexpression also markedly decreased colorectal cancer progression in terms of tumor number and volume of liver metastases in the NT-4 group of the orthotopic liver metastasis model (25 vs. 90% and 4±1 vs. 709±190 mm3, p<0.001 and p<0.05). Collectively, our findings indicate that NT-4 overexpression decreases colorectal lung metastasis and its associated lymph node involvement. NT-4 overexpression decreases tumor recurrence and metastasis after surgical resection, likely via an anti-angiogenic effect. These observations suggest that NT-4 may hold therapeutic potential in the treatment of colorectal cancer growth and major metastatic sites.
Article: Ephrin-B2–Activated Peripheral Blood Mononuclear Cells From Diabetic Patients Restore Diabetes-Induced Impairment of Postischemic Neovascularization[Show abstract] [Hide abstract]
ABSTRACT: We hypothesized that in vitro treatment of peripheral blood mononuclear cells (PB-MNCs) from diabetic patients with ephrin-B2/Fc (EFNB2) improves their proangiogenic therapeutic potential in diabetic ischemic experimental models. Diabetes was induced in nude athymic mice by streptozotocin injections. At 9 weeks after hyperglycemia, 10(5) PB-MNCs from diabetic patients, pretreated by EFNB2, were intravenously injected in diabetic mice with hindlimb ischemia. Two weeks later, the postischemic neovascularization was evaluated. The mechanisms involved were investigated by flow cytometry analysis and in vitro cell biological assays. Paw skin blood flow, angiographic score, and capillary density were significantly increased in ischemic leg of diabetic mice receiving EFNB2-activated diabetic PB-MNCs versus those receiving nontreated diabetic PB-MNCs. EFNB2 bound to PB-MNCs and increased the adhesion and transmigration of PB-MNCs. Finally, EFNB2-activated PB-MNCs raised the number of circulating vascular progenitor cells in diabetic nude mice and increased the ability of endogenous bone marrow MNCs to differentiate into cells with endothelial phenotype and enhanced their proangiogenic potential. Therefore, EFNB2 treatment of PB-MNCs abrogates the diabetes-induced stem/progenitor cell dysfunction and opens a new avenue for the clinical development of an innovative and accessible strategy in diabetic patients with critical ischemic diseases.
Article: Bone marrow-derived endothelial and hematopoietic precursors cells enhance the metastasis of colon cancer in an orthotopic murine model
Article: Neuropilin-1 is upregulated in hepatocellular carcinoma and contributes to tumour growth and vascular remodelling[Show abstract] [Hide abstract]
ABSTRACT: Neuropilin-1 (NRP1) is a transmembrane co-receptor for semaphorins and heparin-binding pro-angiogenic cytokines, principally members of the vascular endothelial growth factor family. Recent studies revealed an important role of NRP1 in angiogenesis and malignant progression of many cancers. The role of NRP1 in the development of hepatocellular carcinoma (HCC) is not completely understood. We used human tissue microarrays and a mouse transgenic model of HCC to establish the spatio-temporal patterns of NRP1 expression in HCC. To evaluate the therapeutic potential of targeting NRP1 in HCC, we treated HCC mice with peptide N, an NRP1 binding recombinant protein and competitive inhibitor of the VEGF-A(165)/NRP1 interaction. We demonstrate that NRP1 is expressed in hepatic endothelial cells of both human healthy biopsies and in HCC samples, but not in normal hepatocytes. We found that increased NRP1 expression in human tumour hepatocytes is significantly associated with primary HCC. Using RT-PCR, Western blot and immunofluorescence analysis we show that NRP1 expression in the liver of transgenic HCC mice is increased with disease progression, in both vascular and tumour compartments. Blocking NRP1 function with peptide N leads to the inhibition of vascular remodelling and tumour liver growth in HCC mice. Our results indicate a specific role of NRP1 in HCC growth and vascular remodelling and highlight the possibility of therapeutically targeting NRP1 for the treatment of HCC.
Article: Further Pharmacological and Genetic Evidence for the Efficacy of PlGF Inhibition in Cancer and Eye Disease[Show abstract] [Hide abstract]
ABSTRACT: Our findings that PlGF is a cancer target and anti-PlGF is useful for anticancer treatment have been challenged by Bais et al. Here we take advantage of carcinogen-induced and transgenic tumor models as well as ocular neovascularization to report further evidence in support of our original findings of PlGF as a promising target for anticancer therapies. We present evidence for the efficacy of additional anti-PlGF antibodies and their ability to phenocopy genetic deficiency or silencing of PlGF in cancer and ocular disease but also show that not all anti-PlGF antibodies are effective. We also provide additional evidence for the specificity of our anti-PlGF antibody and experiments to suggest that anti-PlGF treatment will not be effective for all tumors and why. Further, we show that PlGF blockage inhibits vessel abnormalization rather than density in certain tumors while enhancing VEGF-targeted inhibition in ocular disease. Our findings warrant further testing of anti-PlGF therapies.
Article: Rosuvastatin Counteracts Vessel Arterialisation and Sinusoid Capillarisation, Reduces Tumour Growth, and Prolongs Survival in Murine Hepatocellular Carcinoma[Show abstract] [Hide abstract]
ABSTRACT: Background and Aims. An arterial blood supply and phenotypic changes of the sinusoids characterise the liver vasculature in human hepatocellular carcinoma (HCC). We investigated the effects of rosuvastatin on liver vessel anomalies, tumour growth and survival in HCC. Methods. We treated transgenic mice developing HCC, characterized by vessel anomalies similar to those of human HCC, with rosuvastatin. Results. In the rosuvastatin group, the survival time was longer (P < .001), and liver weight (P < .01) and nodule surface (P < .01) were reduced. Rosuvastatin decreased the number of smooth muscle actin-positive arteries (P < .05) and prevented the sinusoid anomalies, with decreased laminin expression (P < .001), activated hepatic stellate cells (P < .001), and active Notch4 expression. Furthermore, rosuvastatin inhibited endothelial cell but not tumour hepatocyte functions. Conclusions. Rosuvastatin reduced the vessel anomalies and tumour growth and prolonged survival in HCC. These results represent new mechanisms of the effects of statin on tumour angiogenesis and a potential target therapy in HCC.
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ABSTRACT: Angiotensinogen, a member of the serpin family, is involved in the suppression of tumor growth and metastasis. To investigate whether human angiotensinogen protects against tumor progression in vivo, we established an original bitransgenic model in which transgenic mice expressing human angiotensinogen (Hu-AGT-TG mice) were crossed with a transgenic mouse model of hepatocellular carcinoma (HCC-TG mice). Bitransgenic mice overexpressing human angiotensinogen (HCC/Hu-AGT-TG) had a significantly longer survival time than the HCC-TG mice and a reduction of both tumor growth and blood flow velocities in the liver. This antitumor effect of angiotensinogen is related to a reduced angiogenesis, impaired expression of endothelial arterial markers (active Notch4, Delta-like 4 ligand, and ephrin B2) with a decrease of arterial vessel density in HCC/Hu-AGT-TG mice liver. Overexpression of human angiotensinogen decreases angiogenesis, and prevents tumor sinusoids from remodeling and arterialization, thus delaying tumor progression in vivo.
Article: The Role of the Vascular Endothelial Growth Factor-Delta-like 4 Ligand/Notch4-Ephrin B2 Cascade in Tumor Vessel Remodeling and Endothelial Cell Functions[Show abstract] [Hide abstract]
ABSTRACT: Vascular endothelial growth factor (VEGF) and Delta-like 4 ligand (DLL4) are the only genes whose haploinsufficiency results in vascular abnormalities. Although many common pathways are up-regulated in both vascular development and tumor angiogenesis and in vascular remodeling, the role of the Delta/Notch pathway has not been clearly defined in tumor angiogenesis. In this study, we assessed the expression of DLL4, Notch4, and ephrin B2 in transgenic mice developing hepatocarcinoma characterized by a strong remodeling of the tumor sinusoids. We also investigated the role of VEGF in the expression and biological functions of these molecules on human venous endothelial cells. In transgenic livers, we showed that DLL4, active Notch4, and ephrin B2 were gradually up-regulated within the hepatocarcinoma progression and expressed on tumor sinusoidal endothelial cells. In venous endothelial cells, we showed that VEGF up-regulates DLL4 and presenilin, and increased the activation of Notch4, leading to an up-regulation of ephrin B2 with a down-regulation of Eph B4. We also showed that the activation of Notch4 is required for VEGF-induced up-regulation of ephrin B2 and the differentiation of human venous endothelial cells in vitro. Accordingly, the disruption of Notch4 signaling by pharmacologic inhibition of presenilin or addition of soluble DLL4 inhibited the effect of VEGF on human venous endothelial cell migration and differentiation. Our study strongly suggests that a coordinated activation of DDL4/Notch4 and ephrin B2 pathways downstream of VEGF plays a key role in the abnormal remodeling of tumor vessels.
Article: Platelet factor 4 disrupts the intracellular signalling cascade induced by vascular endothelial growth factor by both KDR dependent and independent mechanisms[Show abstract] [Hide abstract]
ABSTRACT: The mechanism by which the CXC chemokine platelet factor 4 (PF-4) inhibits endothelial cell proliferation is unclear. The heparin-binding domains of PF-4 have been reported to prevent vascular endothelial growth factor 165 (VEGF(165)) and fibroblast growth factor 2 (FGF2) from interacting with their receptors. However, other studies have suggested that PF-4 acts via heparin-binding independent interactions. Here, we compared the effects of PF-4 on the signalling events involved in the proliferation induced by VEGF(165), which binds heparin, and by VEGF(121), which does not. Activation of the VEGF receptor, KDR, and phospholipase Cgamma (PLCgamma) was unaffected in conditions in which PF-4 inhibited VEGF(121)-induced DNA synthesis. In contrast, VEGF(165)-induced phosphorylation of KDR and PLCgamma was partially inhibited by PF-4. These observations are consistent with PF-4 affecting the binding of VEGF(165), but not that of VEGF(121), to KDR. PF-4 also strongly inhibited the VEGF(165)- and VEGF(121)-induced mitogen-activated protein (MAP) kinase signalling pathways comprising Raf1, MEK1/2 and ERK1/2: for VEGF(165) it interacts directly or upstream from Raf1; for VEGF(121), it acts downstream from PLCgamma. Finally, the mechanism by which PF-4 may inhibit the endothelial cell proliferation induced by both VEGF(121) and VEGF(165), involving disruption of the MAP kinase signalling pathway downstream from KDR did not seem to involve CXCR3B activation.
Article: Ex vivo differentiated endothelial and smooth muscle cells from human cord blood progenitors home to the angiogenic tumor vasculature[Show abstract] [Hide abstract]
ABSTRACT: Recent studies have provided increasing evidence that postnatal neovascularization does not rely exclusively on sprouting of preexisting vessels, but also involves bone marrow-derived circulating endothelial precursors (BM-EPCs). Animal studies revealed that neovascularization of ischemic tissue can be enhanced by BM-EPCs transplantation. But a possible limitation to the use of vascular precursors for therapeutic angiogenesis is the relatively low number of these cells. In this study, we demonstrate that ex vivo expanded differentiated endothelial cells (ECs) and smooth muscle cells (SMCs), may home to the tumor vasculature allowing targeting of transgene expression to the neoangiogenic site. Mononuclear cells (MNCs) or CD34+ -enriched cells were purified from cord blood. We have defined culture conditions in which we observed two types of clones easily differentiated according to their morphology: cobblestone or spindle-shaped. Phenotypic characterization was assessed by immunocytochemistry, flow cytometry analysis and polymerase reaction with reverse transcription. Formation of capillary-like network in vitro was studied in three-dimensional collagen culture. And recruitment of these cells to a tumoral neoangiogenic site was assessed into tumor-bearing Severe Combined Immunodeficient (SCID) mouse model. The cobblestone cells uniformly positive for CD31, VE-cadherin, vWF, VEGF R1 and R2, ecNOS and incorporating acetylated LDL were ECs. Spindle-shaped cells expressed alpha-smooth muscle actin (alpha-SMA), Smooth Muscle Heavy Chain (SMHC), SM22 and calponin. They also displayed a carbachol-induced contractility in a medium containing IGF1. So we concluded that spindle-shaped cells were SMCs. ECs and SMCs interacted with each other to form a capillary like network in three-dimensional type I collagen culture. Moreover, these ex vivo differentiated cells are able to home to the tumor vasculature. We provide evidence that progenitors for ECs and SMCs circulate in human cord blood and differentiate into functional ECs and SMCs. These differentiated cells could provide a biomaterial for vascular cell therapy, because of their homing capacity to the neovascularization site.
Article: Platelet factor 4 inhibits FGF2-induced endothelial cell proliferation via the extracellular signal-regulated kinase pathway but not by the phosphatidylinositol 3-kinase pathway[Show abstract] [Hide abstract]
ABSTRACT: Platelet factor 4 (PF-4) is a member of the chemokine family with powerful antiangiogenic properties. The mechanism by which PF-4 inhibits endothelial cell proliferation is unclear. We investigated the effects of PF-4 on the intracellular signal transduction induced by basic fibroblast growth factor (FGF2). We found that PF-4 (10 microg/mL) inhibited the FGF2-induced proliferation of adrenal cortex capillary endothelial (ACE) cells. The inhibition of MEK1/2 (mitogen-activated protein kinase kinase) by PD98059 or of PI3K (phosphatidylinositol 3-kinase) by Ly294002 abolished the proliferation induced by FGF2, suggesting that ACE cell proliferation required dual signaling through both the extracellular signal-regulated kinase (ERK) and PI3K pathways. Ly294002 had no significant effect on ERK phosphorylation, whereas PD98059 had a weak effect on the phosphorylation of Akt, suggesting that 2 separate cascades are required for ACE cell proliferation. The addition of PF-4 (10 microg/mL) significantly inhibited ERK phosphorylation (95%), showing that PF-4 acted directly on or upstream from this kinase. Surprisingly, PF-4 did not affect FGF2-induced Akt phosphorylation. This suggests that PF-4 disrupts FGF2 signaling via an intracellular mechanism of inhibition. To exclude the possibility that PF-4 inhibited the binding of FGF2 to only one FGF receptor, preferentially activating the ERK pathway, we investigated the effect of PF-4 on FGF2-induced ERK and Akt phosphorylation, using mutant heparan sulfate-deficient Chinese hamster ovary cells transfected with the FGF-R1 cDNA. The addition of PF-4 (1 microg/mL) significantly inhibited ERK phosphorylation (90%), with no effect on Akt phosphorylation, suggesting that PF-4 acts downstream from the FGF-R1 receptor. In conclusion, this is the first report showing that PF-4 inhibits FGF2 activity downstream from its receptor.
Top Journals
- Cancer Research (2)
- Cancer Research (2)
- Blood (1)
- Cardiovascular Research (1)
- European Journal of Biochemistry (1)
Paris Diderot UniversityLutetia Parisorum, Île-de-France, France
Institut des Systèmes Complexes, Paris Île-de-FranceLutetia Parisorum, Île-de-France, France
University of Paris-EstLa Haye-Descartes, Centre, France
Unité Inserm U1077Caen, Lower Normandy, France


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We're sure you've seen photochromic lenses that change from almost clear to tinted when exposed to sunlight. They've been in commercials and surely someone in your family, office, or classroom has a pair. With photochromic lenses, you don't need to switch from your regular glasses to sunglasses when you step outside. They're incredibly convenient and pretty cool.
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These lenses are just gorgeous! I can't wait to order some.


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We are a BMW repair and specialist shop with a 5,000 square foot facility located in Winter Park, Florida. Our state of the art diagnostic and programming technology is second to none.read more
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- 324Promote
Throw Pillow
scoutby Börg
Throw Pillow made from 100% spun polyester poplin fabric, a stylish statement that will liven up any room. Individually cut and sewn by hand, each pillow features a double-sided print and is finished with a concealed zipper for ease of care. Sold with or without faux down pillow insert.
so cool! Börg
Very Cool!
love it!
love it!
thank you 2 !
As always, great! Carpe Diem
thank you, Luis !
love this!
thanks, Eric !
nice one
i like this.
thank you, Mr. E and suzy :)
this is awesome! check out my stuff?
awesome drawing but I'd make it smaller on the tee. :)
Aww, this is so pretty and colorful :D
Lovely work, great colours :)
thank you all!
Villaraco, yeah I already thought about making it a little smaller aswell , thanks :)
Villaraco, yeah I already thought about making it a little smaller aswell , thanks :)
Beautiful work, such lovely colours Borg !!
This is all kinds of awesome!
thank you 2 :)
Great patterns within a great camera!
thanks Frances :D
you have such a distinct unique style, I love it! keep up the great work man
thanks, michael ! glad you like my stuff , yours is awesome, too :)
I love it!
thank you :)
super cool!..well done :)
thanks, tom !
glad you like it :)
thanks, Kurt!
nice one!
When I look at my camera, this is what I see. A fun, friendly companion that helps me accomplish the things I imagine.
Love it!
Hey I Really like your stuff. So unique! I liked&followed you.
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October 31, 2013
Match- up - how the Bulls fare against Houston
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USF takes on Houston on national television in an American Conference game Thursday. The Bulls come in 2-5 after a 34-3 loss to Louisville at home while Houston downed Rutgers on the road, 49-14.
Make sure to follow our live blog during the game by clicking here


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"Your vision, Our Passion!"
Welcome to Shadowcast Media
We specialize in bringing fresh, new stories to the world of film and television. Our studio houses television and film equipment to handle all of your production needs. We're currently looking for talented actors and actresses to join our ranks. Visit our contact page to inquire within and thanks for visiting!
Actor Reels
Promote Your Talent
Shadowcast Media has held countless auditions for actors and actresses in various parts of the United States. What continues to confuse us are the countless numbers of actors and actresses without demo reels. One of the easiest ways to stymie an acting career is to appear at an audition unprepared. Casting agents review hundreds of actors and actresses on a daily basis looking for talent. Who gets ignored? Those without reels. Studios and production houses WILL NOT
Promote Your Talent (cont'd)
rely simply on a pretty face - you have to show the 'goods' and one of the most effective ways of doing so is promoting yourself in a lead role or interesting character within a production. Shadowcast Media provides private consultation and develops projects** focused around your strongest abilities - with a primary goal to create a reel that will mesmerize and captivate decision makers to get you that dream role. Contact us today!
** - Available to select applicants
Queenie: Priestess of the Ghetto
Click here to see the full film!
Candy Johnson (Karisha McBride) learns that a gift for helping people is a bit more than just good communication skills. However, that gift soon becomes a curse as forces unknown seek to destroy everything that she is. Candy must survive long enough to escape her pursuers and in doing so, discover her family's true name - will she survive?
Time Lord
Click here to view the short film.
The Time Lord is a short film revolving around the cruel and shady universe of ray truth, a contract killer by trade. no one around him is trustworthy - and in such a world, isolation seems to be the best cure. However, like his victims, time is running out for Ray. His final job proves to be his most difficult. For within his chosen occupation, a conscience can truly be deadly..
Click here to view the short film.
A young man recently deals with a devastating diagnoses
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Shadowcast Media is constantly writing and producing new and cutting-edge programming. Would you like to here about upcoming auditions and events? Register with us today!
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Houston, TX


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Areas of Law
- Hospital Law
- Health Care Law
- Acquisitions, Mergers and Joint Ventures
- Administrative Law
Peer Rating
Overall Peer Rating5.0 out of 5.0
No feedback is available.The individuals that have reviewed this lawyer have not provided any additional feedback.
- Meets very high criteria of general ethical standards
Experience & CredentialsPositionDirectorAdmission DetailsAdmitted in 1970, Virginia
U.S. District Court, Eastern and Western Districts of Virginia
U.S. Court of Appeals, Fourth Circuit
U.S. Court of Military Appeals
U.S. Supreme CourtLaw School AttendedT.C. Williams School of Law, University of Richmond
J.D.University AttendedVirginia Military Institute
B.A.Special AgenciesState Department of Health; Mental Health, Mental Retardation and Substance Abuse; Medical Assistance Services; State Health Care Regulatory Boards.
Community ContributionsArticles Blogs Q&A
... Read more
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Contact InformationFirm AddressHancock, Daniel, Johnson & Nagle, P.C.
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Glen Allen, VA 23060
U.S.A.Phone(804) 967-9604Fax(804) 967-9888Website


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- Homepage >
- News Archives >
- Article
Teamwork makes for a Ready and Resilient force
October 16, 2013
By Lt. Gen. Donald M. Campbell Jr., U.S. Army Europe commanding general
Related Links
Hello USAREUR Team,
Over the past few months I have talked extensively about the Army's Ready and Resilient Campaign, from what it entails to the resources it offers our great Soldiers, civilians and families, to what I expect from leaders at every level when it comes to taking care of our own.
I am continually impressed as I travel around United States Army Europe, whether it's at a unit or an installation, I see increased leader engagement and I see Soldiers at every level looking for ways to combat the serious issues that face our force today.
I am certain that we are on the right path and together we can accomplish any mission and overcome any challenge.
To that end, October is Domestic Violence Awareness Month, and I'd like to take a moment to discuss the Army's comprehensive approach to the prevention of domestic abuse.
The Army is fully committed to supporting its Soldiers and families by overcoming harmful issues that affect the health and well-being of the force.
Domestic abuse, at any degree of severity, undermines that commitment. The Army provides varying degrees of resources such as ACS programs, chaplains and behavioral health specialists, which everyone can use to prevent domestic abuse and develop skills to help restore stability and health if needed.
As our Army has seen multiple deployments in over 12 years of persistent conflict, our Soldiers and their families live with multiple stressors, and wounds that may not be visible. The entire Army community must work together as a team to prevent abuse, protect victims and hold offenders accountable when abuse occurs.
Together, we can combat issues like this if we focus on caring for and about ourselves, those around us, and the communities we live in.
On that note, I would like to remind everyone that the 2013 Combined Federal Campaign-Overseas (CFC-O) is currently ongoing.
This year's theme is "Serve to honor your country. Give because you care." Military, civilian personnel and federal employees can donate to more than 2,600 national and international charities through the campaign.
Last year, donations from USAREUR totaled more than $2.2 million. The CFC-O is currently the only authorized avenue for charitable organizations to solicit Department of Defense uniformed service members and civilian employees stationed abroad.
Contributions can range from $1 per month for a single charity to a one-time donation for multiple charities. This year, for the first time, military and civilian personnel will be able to use My Pay to make their contributions.
Contact your local unit CFC-O representative today to get more information or visit the USAREUR home page under Hot Topics. The campaign ends Nov. 15.
Strong Soldiers, Strong Teams!


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So I was wondering if you guys know how late into a pregnancy you can get a pre-natal massage?
I'll be 30 weeks monday, and I planned on going beginning of July when I get my extra pay check, so I'll be...34-35? I dont wanna go into labor or anything!!!


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Are you Peihua Gu?Claim your profile
Publications (2)3.77 Total impact
Article: Sex differences in the association between dietary restraint, insulin resistance and obesity[Show abstract] [Hide abstract]
ABSTRACT: Background & Aims Restrained food consumption may alter metabolic function and contribute to eventual weight gain; however, sex differences in these relationships have not been assessed. The objective of this study was to examine the relationship between restrained eating and insulin resistance and the influence of body mass index and sex on this relationship in a large community sample of both men and women. We hypothesized that restrained eating would be related to insulin resistance and this relationship would be influenced by sex and body mass index. Methods In this cross-sectional, observational study, we studied 487 individuals from the community (men N = 222, women N = 265), who ranged from lean (body mass index 18.5-24.9 kg/m2, N = 173), overweight (body mass index 25-29.9 kg/m2, N = 159) and obese (body mass index > 30 kg/m2, N = 155) weight categories. We assessed restrained eating using the Dutch Eating Behavior Questionnaire and obtained fasting morning plasma insulin and glucose on all subjects. Results In men, but not in women, restrained eating was related to homeostatic model assessment of insulin resistance (HOMA-IR) (p < 0.0001). Furthermore, homeostatic model assessment of insulin resistance levels were significantly higher in men who were high- versus low-restrained eaters (p = 0.0006). Conclusions This study is the first to report sex differences with regard to the relationship between restrained eating and insulin resistance. Our results suggest that high restraint eating is associated with insulin resistance in men but not in women.
- [Show abstract] [Hide abstract]
ABSTRACT: The stress-vulnerability model of addiction predicts that environmental factors, such as cumulative stress, will result in individual adaptations that decrease self-control, increase impulsivity, and increase risk for addiction. Impulsivity and cumulative stress are risk factors for tobacco smoking that are rarely examined simultaneously in research. We examined the indirect and direct effects of cumulative adversity in a community sample consisting of 291 men and women who participated in an assessment of cumulative stress, self-reported impulsivity, and smoking history. Data were analyzed using bootstrapping techniques to estimate indirect effects of stress on smoking via impulsivity. Cumulative adversity is associated with smoking status via direct effects and indirect effects through impulsivity scores. Additional models examining specific types of stress indicate contributions of traumatic stress and recent life events as well as chronic relationship stressors. Overall, cumulative stress is associated with increased risk of smoking via increased impulsivity and via pathways independent of impulsivity. These findings support the stress-vulnerability model and highlight the utility of mediation models in assessing how, and for whom, cumulative stress increases risk of current cigarette smoking. Increasing self-control is a target for interventions with individuals who have experienced cumulative adversity.
Top Journals
Yale University
New Haven, Connecticut, United States
- Department of Psychiatry


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Fact Sheet
For Immediate Release
Laboratory Services
The ATF Laboratory Services Division provides analytical and advisory services on scientific matters. Laboratory services is comprised of four organizational groups: the Forensic Science Laboratories (FSL), with facilities in Atlanta, San Francisco, Washington, D.C. and the Fire Research Laboratory (FRL). The Washington FSL and the FRL are collocated with Laboratory Services administrative offices at the National Laboratory Center in suburban Maryland.
The ATF laboratories have a distinguished history dating back to 1886. From two scientists working in the attic of the U.S. Treasury building, the operation has grown to a staff of more than 100 professionals. ATF laboratories are committed to providing accurate and authoritative scientific information needed to reduce violent crime and protect the public.
ATF laboratories are staffed with chemists, scientists, forensic biologists, engineers, fingerprint specialists, firearm and tool mark examiners, document examiners, and administrative personnel. ATF laboratory personnel hold leadership positions in numerous professional scientific organizations and are among the most highly qualified specialists in their fields. ATF actively supports and encourages professional certification of its scientists and engineers. Laboratory staff is made up of highly trained individuals specializing in the examination of evidence typically seen in fire, explosives and firearm related crimes who perform forensic exams, provide technical support, expert witness testimony, and advanced training to a wide range of national and international law enforcement personnel.
In fiscal year 2014, ATF's laboratories accomplished the following:
- Processed 2,220 forensic cases
- Processed 118 fire research cases
- Provided 83 days of expert testimony in the courts
- Worked 160 days at crime scenes
- Provided 671 days of training instruction for federal, state and local investigators and examiners
ATF laboratory personnel were involved in the creation of a national accreditation program for forensic laboratories. In 1984, ATF was the first federal laboratory to be accredited by the American Society of Crime Laboratory Directors/Laboratory Accreditation Board (ASCLD/LAB). In 2011, the ATF laboratories underwent evaluations for accreditation to the ASCLD/LAB - International standards. Under the International Program ASCLD/LAB assesses a laboratory's capability using the International Organization of Standardization (ISO/IEC) 17025 General requirements for the competence of testing and calibration laboratories and the ASCLD/LAB International Supplemental requirements for forensic laboratories. The accreditation standards include requirements for personnel qualifications, evidence handling and preservation techniques, instrument maintenance, written protocols and procedures, calibration and use of comparison standards, internal and external proficiency testing, continuing education and report writing. In order to maintain accreditation, the laboratories undergo vigorous on site audits performed by ASCLD/LAB assigned assessors once every five years, with smaller surveillance visits occurring every 16 to 18 months.


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@thedude-abides Now for a little TRUE perspective. Hobo With A Shotgun is an obvious exploitation film. It came to fruition when it won a trailer contest to be included in Tarantino/Rodriguez's film GRINDHOUSE. It was then made into a feature film ala Machete, and was released in theatres I KNOW this because i saw it in theatres...TWICE! Both showings were packed and everyone was laughing hysterically because they were aware of what it was. A spoof of exploitation and low budget action films from the 80's i.e. Big Trouble In Little China. Check your facts before you go spouting off about something you knew nothing about.
F*ck this JLA can be done without Batman
@brian half of these super hero films announced won't even be made. Hulk 2, Daredevil 2, Fantastic Four 3, Magneto, Aquaman, Spawn Reboot, Blade Reboot, Justice League, and many others were all announced to have scripts and set to go into production but none of them happened. If Avengers fails (i hope not) then JLA will get the axe instantly. These X-Men movies will likely happen as First Class looks excellent.
"nah hes a f*g and sucked in Breach and cant be take seriously as an actor no thanks" a ridiculously ignorant statement that makes you seem to have the I.Q of a baboon. Ryan has plenty of range he's great in Cruel Intentions, Flags Of Our Fathers, Crash, and Stop-Loss he'd be a fantastic Captain America.


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The band:
Phil Lesh, Chris Robinson (vocals, guitar)
Larry Campbell (guitar, mando,violin, ps, etc)
John Molo (drums), Mookie Siegel (keys)
Barry Sless (guitar+pedalsteel)
Mixed and mastered by Wiz
CD covers can be found at www.phillesh.net
Big thanks to all the mirror sites!
Notes: static bursts at the beginging of d2t06 (Cryptical)... 00:06-00:07..
and then another slight burst at 00:17-00:19.....
These are on the master DSBD source. It was apparently caused by Phil's wireless
bass rig and appears on AUD copies as it came through the PA.
These two spots have been edited to soften the static. No other flaws noted.


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Capital Markets
Company Overview of PIMCO Funds - PIMCO Emerging Local Bond Fund
Company Overview
650 Newport Center Drive
Newport Beach, CA 92660
United States
Founded in 2006
Key Executives for PIMCO Funds - PIMCO Emerging Local Bond Fund
PIMCO Funds - PIMCO Emerging Local Bond Fund Key Developments
PIMCO Funds - PIMCO Emerging Local Bond Fund, Special/Extraordinary Shareholders Meeting, Apr 20, 2015., at 09:00 Pacific Standard Time. Location: Newport Beach Marriott Hotel & Spa. Agenda: To elect six trustees to the Board of Trustees.
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Only a company representative may request an update for the company profile. Documentation will be required.
To contact PIMCO Funds - PIMCO Emerging Local Bond Fund, please visit investments.pimco.com/Products/pages/292.aspx. Company data is provided by Capital IQ. Please use this form to report any data issues.
Our data partners will research the update request and update the information on this page if necessary. Research and follow-up could take several weeks. If you have questions, you can contact them at email@example.com.


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Rarity:male by MinomotuWatch
©2011-2016 Minomotu
Excuse me minomotu. I'm interested in cosplaying as Elusive in the future so I'd like to use yours as my model base for his cosplay if that's all right. As requested, I'll give you recognition of your work and might make only slight differences with clothing but mainly use your picture as reference. I really appreciate this if you will. Thank you.
Yeah sure no problem. Have fun!
Beware of that punk, hes gonna kill you!
Nice Elusive.
Heh-low-ther! Damn I with I would draw boys that cute o///O
hi you should make the other four
For the love of god, would you let people cosplay this if they gave you credit? because I adore Rarity, but I'm not entirely comfortable wearing a skirt or dress. Pleeeeeease please please 'cause this is just beautiful
Yea thats fine. I would love to see pictures when its done.
I love the pose he looks sweet xD
haha I started imagining him with her voice O.O
Hahaa, perfect! I like that he's paying special attention to his hair...like another pony we know


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Westener 3
by pflegero
Comment posted.
worshamsr says
Looks like you had a great time in CA. Hope you enjoyed my home state
posted at 11:16AM Jul 23 PST
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Published January 17, 2012
singapore exchange
Published December 27, 2011
Blurb Sites


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Students are given a variety of materials and asked to identify if each material as a solid, liquid or gas. They use their five senses — sight, sound, smell, texture and taste — to identify the other characteristics of each item.
Engineering Connection
Educational Standards
Each TeachEngineering lesson or activity is correlated to one or more K-12 science, technology, engineering or math (STEM) educational standards.
All 100,000+ K-12 STEM standards covered in TeachEngineering are collected, maintained and packaged by the Achievement Standard Network (ASN), a project of JES & Co. (www.jesandco.org).
In the ASN, standards are hierarchically structured: first by source; e.g., by state; within source by type; e.g., science or mathematics; within type by subtype, then by grade, etc.
Click on the standard groupings to explore this hierarchy as it applies to this document.
- Colorado: Math
- Measure and estimate lengths in standard units. (Grade 2) [2010] ...show
- Colorado: Science
- c. Identify the state of any sample of matter (Grade 3) [2009] ...show
- Common Core State Standards for Mathematics: Math
- 4. Generate measurement data by measuring lengths using rulers marked with halves and fourths of an inch. Show the data by making a line plot, where the horizontal scale is marked off in appropriate units— whole numbers, halves, or quarters. (Grade 3) [2010] ...show
- International Technology and Engineering Educators Association: Technology
- Next Generation Science Standards: Science
- Make observations and measurements to identify materials based on their properties. (Grade 5) [2013] ...show
Pre-Req Knowledge
Learning Objectives
- Explain that there are different types of materials suited for different purposes and that engineers must decide which material is best suited for a specific task.
- Describe how our five senses help us learn about different materials.
Materials List
- Wooden blocks
- Jell-O®
- Peanut butter
- Water
- Ice
- Paper
- Ketchup
- Pipe cleaners
- Oil
- Elmer's glue
- Bubble gum
- Scotch Tape®
- LEGO® blocks
- Eggs: hard boiled or raw
- Saran Wrap®
- Marshmallows
- Feathers
- Bouncy ball
- Dog toy that squeaks
- Chocolate
- Silly putty
- Sticky tack
- Sandpaper
- Wool
- Sunflower seeds
- 1 12"-in. ruler
- 1 beaker or empty water bottle (optional)
- Food coloring (optional)
- Two copies of the You Name It! Worksheet
|A set of characteristics that describe an item.
|Methods of perception; five senses are sight, smell, touch, sound and taste.
Before the Activity
- Make copies of the You Name It! Worksheet for each student.
- Gather all necessary materials.
With the Students
- Conduct the Introduction/Motivation section with the students.
- Split the class into groups of two students each.
- Give students clear directions on which items they may and may not taste. Be especially aware of any allergy issues.
- Let each group choose one material to observe and identify the different properties.
- When a group is done, have them switch materials with another group. Note: if it is a food item, give subsequent groups new food to taste.
- Give the students time to fill out the You Name It! Worksheet for six different materials. Encourage students to perform other tests on their materials: does it bounce? Does it pour? Can it stand by itself?
- Once students have filled in their You Name It! Worksheet, have them choose their favorite material and present their findings about it to the class.
- Review with the students how our five senses help us learn about different materials. Also review how engineers need to know about materials so that they can choose the right material for a specific task or invention.
Safety Issues
Troubleshooting Tips
Pre-Activity Assessment
Activity Embedded Assessment
Post-Activity Assessment
Activity Extensions
Activity Scaling
Katherine Beggs, Denali Lander, Abigail Watrous, Janet Yowell
© 2006 by Regents of the University of Colorado.
Supporting Program
Integrated Teaching and Learning Program, College of Engineering, University of Colorado Boulder
Last modified: February 11, 2016


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Inspired by a real-life behavioral scientist, this FOX drama tells the tale of a deception expert who helps uncover the truth for the FBI, local police, law firms, corporations, and individuals. Dr. Cal Lightman and his team are effectively human polygraph machines, and no truth can be concealed from them. The Lightman Group is headed by Dr. Cal Lightman and his partner Dr. Gillian Foster who is a gifted psychologist. She brings balance to the partnership by thinking about the overall picture while Lightman focuses on the details. Together they make an invincible team with insight into human behavior. Will Loker is the lead researcher, who believes in radical honesty. He often gets in trouble for saying what he thinks. Ria Torres is one of the few "naturals" in the field of deception detection. She has an untapped ability to read people that makes her a force to be reckoned with the right training.
Created by Sam Baum, Lie to Me is executive-produced by Baum, Brian Grazer, David Nevins and Steve Maeda. The series is produced by Imagine Television and 20th Century Fox Television.
Fox has ordered series pickups with Zooey Deschanel-starring comedy The New Girl (formerly titled Chicks and Dicks), as well as dramas Alcatraz from J.J. Abrams, Bones' spinoff The Finder, and Jaime Pressly-starring I Hate My Teenage Daughter. To make room for the new shows, Fox cancelled Breaking In, Traffic Light, The Chicago Code, Lie to Me, and sophomore Human Target.
In The New Girl, Zooey Deschanel stars as "a quirky teacher who moves in with three guys - the cynic, the player and the man-child - after being dumped." Jake M. Johnson, Max Greenfield, and Damon Wayans Jr. play the three guys; Hannah Simone also stars. No Strings Attached writer Elizabeth Meriwether created the series. Jake Kasdan (Walk Hard: The Dewey Cox Story) directed the single-camera pilot.Read More
Fox is announcing premiere dates for new and returning series, as well as revisions to its 2010-2011 midseason schedule, including American Idol's move to Wednesdays and Thursdays and Glee continuing to lead off FOX's Tuesday night of comedies featuring Raising Hope and the debut of Mixed Signals.
Television's No. 1 series, American Idol, moves to Wednesdays and Thursdays beginning with a two-night premiere event Wednesday, Jan. 19 (8:00-10:00 PM ET/PT) and Thursday, Jan. 20 (8:00-9:00 PM ET/PT). American Idol welcomes new judges Jennifer Lopez and Steven Tyler, who join judge Randy Jackson and host Ryan Seacrest, and an all-new crop of hopefuls from auditions held in Austin, Los Angeles, Milwaukee, Nashville, New Orleans, San Francisco and East Rutherford, NJ.Read More
Lone Star is the first big causality of the new fall season, airing just two episodes on Fox before getting the ax. Upon announcement of the cancellation, 20th Century Fox TV immediately stopped production on the series, which was in the middle of shooting its sixth episode. It is not clear what will happen to the three unaired episodes at this point.
According to Deadline, Lone Star will be replaced in Fox's Monday at 9 pm timeslot by the third season of Lie to Me, which returns to the air sooner than expected.Read More
The hit Fox series Lie to Me: The Complete Second Season will be released on DVD on November 9. This six-disc set will contain all 22 episodes of this new season and will be priced at $59.99 SRP. You can take a look at the cover art and special features below. The series stars Tim Roth, Kelli Williams, Brendan Hines, Monica Raymund, Mekhi Phifer and Hayley McFarland.
Most people cannot tell from demeanor or body language when others are lying -- this is best left to the experts. From executive producers of 24 and Arrested Development comes Lie to Me, a drama of a deception expert who helps uncover the truth for the FBI, local police, law firms, corporations, and individuals.Read More
Fox has set the fall premiere dates for its new and returning series. The 2010-2011 season on Fox will kick off with a special premiere week beginning Monday, Sept. 20. House and the Princeton Plainsboro team return for a seventh season Monday, Sept. 20 (8:00-9:00 PM ET/PT) followed by the series premiere of the sophisticated and provocative drama Lonestar (9:00-10:00 PM ET/PT). This fall, Tuesdays feature a night of pitch-perfect comedy beginning Sept. 21 with the highly anticipated return of Glee (8:00-9:00 PM ET/PT) and the series premieres of new family comedy Raising Hope (9:00-9:30 PM ET/PT) and new romantic comedy Running Wilde (9:30-10:00 PM ET/PT) starring Will Arnett and Keri Russell. On Wednesday, Sept. 22, things heat up for Gordon Ramsay in the two-hour premiere of the eighth season of Hell's Kitchen (8:00-10:00 PM ET/PT). The thrill is on Thursdays when Bones (8:00-9:00 PM ET/PT) and Fringe (9:00-10:00 PM ET/PT) return beginning Sept. 23.
Action-packed weekends kick off Fridays with the return of Human Target (8:00-9:00 PM ET/PT) and the time period premiere of The Good Guys (9:00-10:00 PM ET/PT) on Sept. 24. Saturdays are still the most arresting night of television with the season premieres of Cops (8:00-8:30 and 8:30-9:00 PM ET/PT) - celebrating its milestone 800th episode - and America's Most Wanted (9:00-10:00 PM ET/PT) on Sept. 11. Sundays are side-splittingly funny when Animation Domination makes its return Sept. 26 with the season premieres of The Simpsons (8:00-8:30 PM ET/PT), The Cleveland Show (8:30-9:00 PM ET/PT) and a one-hour special installment of Family Guy (9:00-10:00 PM ET/PT). American Dad! will mark its milestone 100th episode with its season premiere Sunday, Oct. 3 (9:30-10:00 PM ET/PT). In addition, Lie to Me continues to reveal the truth Wednesday, Nov. 10 (8:00-9:00 PM ET/PT).Read More