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Publications (34)174.59 Total impact
Article: CD-200 induces apoptosis and inhibits Bcr-Abl signaling in imatinib-resistant chronic myeloid leukemia with T315I mutation[Show abstract] [Hide abstract]
ABSTRACT: Chronic myeloid leukemia (CML) is characterized by a constitutively active Bcr-Abl tyrosine kinase. Although Imatinib has been proven to be an effective drug against CML, its resistance has been observed with disease relapse due to T315I predominant point mutation. Liriodendron tulipifera L., one of the fastest growing hardwood tree species, exerts antioxidant activity and anti-inflammatory effects. However, its anticancer effect has been minimally reported. In this study, we extracted CD-200 from Liriodendron tulipifera L. and investigated its effect on cell survival or apoptosis in CML cells with Bcr-Abl/T315I (BaF3/T315I) as well as wild-type Bcr-Abl (BaF3/WT). CD-200 inhibited cell proliferation in the BaF3/WT cells, and also in the BaF3/T315I cells with Imatinib resistance. Moreover, it strongly inhibited Bcr-Abl signaling pathways in a dose-dependent manner. Also, it significantly increased the sub-G1 phase and the expression of cleaved PARP and caspase-3, as well as the TUNEL-positive apoptotic cells. In addition, we observed that CD-200 induced apoptosis with a loss of mitochondrial membrane potential by decreasing the expression of Mcl-1 and survivin. Furthermore, CD-200 showed a significant inhibition in tumor growth, compared to Imatinib in BaF3/T315I mouse xenograft models. Taken together, our study demonstrates that CD-200 exhibits apoptosis induction and anti-proliferative effect by blocking the Bcr-Abl signaling pathways in the Bcr-Abl/T315I with resistance to Imatinib. We suggest that CD-200 may be a natural product to target Bcr-Abl and overcome Imatinib resistance in CML patients.
Article: HS-543 induces apoptosis of Imatinib-resistant chronic myelogenous leukemia with T315I mutation[Show abstract] [Hide abstract]
ABSTRACT: Chronic myeloid leukemia (CML) is characterized by a constitutive activation of Bcr-Abl tyrosine kinase. Bcr-Abl/T315I is the predominant mutation that causes resistance to Imatinib. In the present study, we synthesized a novel Bcr-Abl inhibitor, HS-543, and investigated its effect on cell survival or apoptosis in CML cells bearing Bcr-Abl/T315I (BaF3/T315I) or wild-type Bcr-Abl (BaF3/WT). HS-543 showed anti-proliferative effects in the BaF3/WT cells as well as the BaF3/T315I cells with resistance to Imatinib and strongly inhibited the Bcr-Abl signaling pathway in a dose-dependent manner. Furthermore, it significantly increased the sub G1 phase associated with early apoptosis, with increased levels of cleaved PARP and cleaved caspase-3, as well as the TUNEL-positive apoptotic cells. In addition, we found that HS-543 induced apoptosis with the loss of mitochondrial membrane potential by decreasing the expression of Mcl-1 and survivin, together with increasing that of Bax. In BaF3/T315I xenograft models, HS-543 significantly delayed tumor growth, unlike Imatinib. Our results demonstrate that HS-543 exhibits the induction of apoptosis and anti-proliferative effect by blocking the Bcr-Abl signaling pathway in the T315I-mutated Bcr-Abl cells with resistance to Imatinib. We suggest that HS-543 may be a novel promising agent to target Bcr-Abl and overcome Imatinib resistance in CML patients.
Article: HS-133, a novel fluorescent phosphatidylinositol 3-kinase inhibitor as a potential imaging and anticancer agent for targeted therapy[Show abstract] [Hide abstract]
ABSTRACT: As PI3K/Akt signaling is frequently deregulated in a wide variety of human tumors, PI3K inhibitors are an emerging class of drugs for cancer treatment. The monitoring of the drug behavior and distribution in the biological system can play an important role for targeted therapy and provide information regarding the response or resistance to available therapies. In this study, therefore, we have developed a family of xanthine derivatives, serving as a dual function exhibiting fluorescence, as well as inhibiting PI3K. Among them, HS-133 showed anti-proliferative effects and was monitored for its subcellular localization by a fluorescence microscopy. HS-133 suppressed the PI3K/Akt pathway and induced cell cycle arrest at the G0/G1 phase. The induction of apoptosis by HS-133 was confirmed by the increases of the cleaved PARP, caspase-3, and caspase-8. Furthermore, HS-133 decreased the protein expression of HIF-1α and VEGF, as well inhibited the tube formation and migration of the human umbilical vein endothelial cells. In vivo imaging also showed that tumors were visualized fluorescent with HS-133, and its oral administration significantly inhibited the growth of tumor in SkBr3 mouse xenograft models. Thus, we suggest that HS-133 may be used as a fluorescent anticancer agent against human breast cancer.
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ABSTRACT: The c-KIT tyrosine kinase has emerged as a potential therapeutic target for an array of diseases. However, there exists a drug resistance that is caused by mutations in c-KIT; therefore, c-KIT remains as a clinical challenge due to limited effective treatment options for therapies. For example, the acquired activating point mutation D816V significantly impairs the efficacy of targeted cancer therapies. Understanding the mechanisms of drug resistance at the molecular level will aid in designing and developing particular inhibitors with the potential to overcome these resistance mutations. We undertake a structure-based de novo design of 7-azaindole as the molecular core using the modified scoring function. This approach led to an identification of new c-KIT inhibitors over 100-fold specific for the D816V mutant relative to the wild-type c-KIT with nanomolar inhibitory activity. More importantly, these compounds potently inhibit clinically relevant D816V mutations of c-KIT in biochemical and cellular studies.
Article: HS-104, a PI3K inhibitor, enhances the anticancer efficacy of gemcitabine in pancreatic cancer[Show abstract] [Hide abstract]
ABSTRACT: Gemcitabine has limited clinical benefits for pancreatic cancer patients. The phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway is important in cell proliferation and survival, and is frequently dysregulated in pancreatic cancer. To obtain insights into novel therapeutic strategies for treating pancreatic cancer, we investigated whether HS-104, a novel PI3K inhibitor, in combination with gemcitabine would show a synergistic effect in pancreatic cancer. We first evaluated the effect of gemcitabine alone or in combination with HS-104 on cell viability. When administered together, the two drugs synergistically inhibited the viability of AsPC-1 and PANC-1 cells, and decreased mitochondrial membrane potential, thereby inducing apoptosis. Compared to the treatment with either drug alone, the combination treatment resulted in apoptosis accompanied by increased levels of cleaved caspase-3 and Bax. These results were consistent with decreased expression of p-Akt, p-mTOR, p-Mek and p-Erk. Moreover, the combination treatment inhibited blood vessel formation in a Matrigel plug assay in mice. Furthermore, in vivo, the combination significantly inhibited tumor growth and enhanced apoptosis by increasing the number of TUNEL-positive cells, and cleaved caspase-3 together with decreasing the expression of angiogenesis- and proliferation-related effectors such as CD34 and PCNA in tumor tissues, compared with each drug alone. Taken together, our study demonstrates that the combination of gemcitabine and HS-104 had a synergistic anticancer effect and inhibited the PI3K/Akt and RAF/Mek pathways on pancreatic cancers. On the basis of our results, we suggest that the combination of these two drugs may be considered as a new therapeutic regimen for treating pancreatic cancer.
Article: HS-438, a new inhibitor of Imatinib-resistant BCR-ABL T315I mutation in chronic myeloid leukemia[Show abstract] [Hide abstract]
ABSTRACT: Imatinib is a selective breakpoint cluster region-Abelson (BCR-ABL) tyrosine kinase inhibitor (TKI) that has significantly improved the prognosis of patients with chronic myeloid leukemia (CML). However, T315I gene mutations of the BCR-ABL kinase domain have been shown to confer resistance to Imatinib. In the present study, we synthesized a novel BCR-ABL inhibitor, HS-438, and identified its anti-leukemic effects in vitro and in vivo. We found that HS-438 strongly inhibited the expression of BCR-ABL signaling pathways in wild-type BCR-ABL (BaF3/WT) cells as well as T315I-mutated BCR-ABL (BaF3/T315I) cells with resistance to Imatinib. HS-438 induced cell cycle arrest, particularly during the G0/G1 cell cycle phase, and induced apoptosis. In BaF3/T315I xenograft models, HS-438 significantly delayed tumor growth, unlike Imatinib. In summary, we suggest that HS-438 may be a novel drug candidate with the therapeutic potential to target BCR-ABL and overcome Imatinib resistance in patients with CML.
Article: HS-173, a Novel PI3K Inhibitor, Attenuates the Activation of Hepatic Stellate Cells in Liver Fibrosis[Show abstract] [Hide abstract]
ABSTRACT: Hepatic stellate cells (HSCs) are the primary source of matrix components in liver disease such as fibrosis. Phosphatidylinositol 3-kinase (PI3K) signaling in HSCs has been shown to induce fibrogenesis. In this study, we evaluated the anti-fibrotic activity of a novel imidazopyridine analogue (HS-173) in human HSCs as well as mouse liver fibrosis. HS-173 strongly suppressed the growth and proliferation of HSCs and induced the arrest at the G2/M phase and apoptosis in HSCs. Furthermore, it reduced the expression of extracellular matrix components such as collagen type I, which was confirmed by an in vivo study. We also observed that HS-173 blocked the PI3K/Akt signaling pathway in vitro and in vivo. Taken together, HS-173 suppressed fibrotic responses such as cell proliferation and collagen synthesis by blocking PI3K/Akt signaling. Therefore, we suggest that this compound may be an effective therapeutic agent for ameliorating liver fibrosis through the inhibition of PI3K signaling.
Article: SB365, Pulsatilla saponin D suppresses proliferation and induces apoptosis of pancreatic cancer cells[Show abstract] [Hide abstract]
ABSTRACT: Pulsatilla koreana has been used as a traditional medicine for the treatment of various diseases. The purpose of this study was to determine whether SB365, Pulsatilla saponin D isolated from the root of Pulsatilla koreana inhibits the progression of pancreatic cancer. We found that SB365 strongly suppressed the growth and proliferation of 5 human pancreatic cancer cell lines (MIAPaCa-2, BXPC-3, PANC-1, AsPC-1 and HPAC). The apoptotic effect of SB365 was demonstrated by increased levels of cleaved caspase-3 and decreased Bcl-2 expression via mitochondrial membrane potential, as well as elevated numbers of terminal deoxynucleotidyl-transferase-mediated dUTP nick end labeling (TUNEL)-positive apoptotic cells. SB365 was also found to exert an anti-angiogenic effect by decreasing the expression of HIF-1α and VEGF, major factors of angiogenesis, which was confirmed by the suppression of tumor sphere formation of pancreatic cancer cells. An in vivo mouse xenograft study showed that SB365 significantly inhibited tumor growth through the induction of apoptosis and inhibition of angiogenesis with strong anticancer activity. Therefore, SB365 is a good candidate as a natural product for use in the treatment of pancreatic cancer.
Article: A novel imidazopyridine PI3K inhibitor with anticancer activity in non-small cell lung cancer cells[Show abstract] [Hide abstract]
ABSTRACT: Lung cancer is the leading cause of cancer-related mortality in the world, and non-small cell lung cancer (NSCLC) accounts for approximately 85% of all cases. Since more than 60% of NSCLC cases express the epidermal growth factor receptor (EGFR), EGFR tyrosine kinase inhibitors are used to treat NSCLC. However, due to the acquired resistance associated with EGFR-targeted therapy, other strategies for the treatment of NSCLC are urgently needed. Therefore, we investigated the anticancer effects of a novel phosphatidylinositol 3-kinase α (PI3Kα) inhibitor, HS-173, in human NSCLC cell lines. HS-173 demonstrated anti-proliferative effects in NSCLC cells and effectively inhibited the PI3K signaling pathway in a dose‑dependent manner. In addition, it induced cell cycle arrest at G2/M phase as well as apoptosis. Taken together, our results demonstrate that HS-173 exhibits anticancer activities, including the induction of apoptosis, by blocking the PI3K/Akt/mTOR pathway in human NSCLC cell lines. We, therefore, suggest that this novel drug could potentially be used for targeted NSCLC therapy.
Article: Induction of apoptosis and suppression of angiogenesis of hepatocellular carcinoma by HS-159, a novel phosphatidylinositol 3-kinase inhibitor[Show abstract] [Hide abstract]
ABSTRACT: The phosphatidylinositol 3-kinase (PI3K) pathway plays a central role in cell proliferation and survival in human cancer and is emerging as an attractive therapeutic target. In this study, we synthesized a novel PI3Kα inhibitor, HS-159 [N-(5-(3-(3-cyanophenyl)imidazo[1,2-a]pyridin-6-yl)pyridin-3-yl)benzenesulfonamide] and evaluated its anticancer effects on Huh-7 human hepatocellular carcinoma (HCC) cells. HS-159 effectively inhibited the phosphorylation of downstream PI3K effectors such as Akt, mTOR and P70S6 kinases in a dose-dependent manner. This compound also induced apoptosis and increased the fraction of apoptotic cells in the sub-G1 phase as well as the levels of cleaved PARP, caspase-3 and -9. Furthermore, HS-159 decreased the expression of hypoxia inducible factor-1α and vascular endothelial growth factor which play important roles in angiogenesis. The anti-angiogenic effect of HS-159 was confirmed by the suppression of tube formation and migration of human umbilical vein endothelial cells in vitro. Collectively, our results demonstrate that HS-159 exhibited anticancer activities including the induction of apoptosis and inhibition of angiogenesis by blocking the PI3K/Akt pathway in Huh-7 cells. Therefore, we suggest that this drug may be potentially used for targeted HCC therapy.
Article: Discovery of New Benzothiazole-Based Inhibitors of Breakpoint Cluster Region-Abelson Kinase Including the T315I Mutant[Show abstract] [Hide abstract]
ABSTRACT: The existence of drug resistance caused by mutations in the break-point cluster region-Abelson tyrosine kinase (Bcr-Abl) kinase domain remains a clinical challenge due to limited effective treatment options for chronic myeloid leukemia (CML). Herein we report a novel series of benzothiazole-based inhibitors that are effective against wild-type and T315I mutant Bcr-Abl kinases. The original hit compound, nocodazole, was extensively modified through a structure-based drug design strategy, especially by varying the groups at the C2 and C6 positions of the scaffold. In addition, the introduction of water-solubilizing groups at the terminal ethyl group resulted in enhanced physicochemical properties and potency in cellular inhibition. Several compounds inhibited the kinase activity of both wild-type Bcr-Abl and the T315I mutant with IC50 values in the picomolar range and exhibited good antiproliferative effects on Ba/F3 cell lines transformed with either wild-type or T315I mutant Bcr-Abl.
Article: A novel PI3K inhibitor alleviates fibrotic responses in fibroblasts derived from Peyronie's plaques[Show abstract] [Hide abstract]
ABSTRACT: Peyronie's disease (PD) is fibrosis localized in the tunica albuginea that is characterized by penile deformity and curvature. The pathogenesis of this disease remains unclear even though transforming growth factor‑β (TGF-β)/smad signalling has been reported to be associated with PD. Recent studies have shown that phosphoinositide 3-kinase (PI3K)/Akt signalling regulates fibrotic responses including collagen synthesis and cell proliferation. Thus, we synthesized HS-173, a novel PI3K inhibitor, and determined whether this compound has anti-fibrotic effects on PD-derived primary fibroblasts. In this study, we found that HS-173 inhibited the growth of fibroblasts in a dose-dependent manner and induced apoptosis. In addition, HS-173 reduced the expression of α-smooth muscle actin (α-SMA), vimentin, PAI-1, fibronectin, collagen type I, collagen IV and TGF-β-activated smad2/3 in PD-derived primary fibroblasts. HS-173 blocked the PI3K/Akt signalling pathway by decreasing the activation of Akt, mTOR and P70S6K. Our results showed that HS-173 suppressed fibrotic responses such as cell proliferation and collagen synthesis by blocking PI3K/Akt signalling in PD-derived primary fibroblasts. Our findings provide molecular insights into the potential therapeutic action of HS-173 through targeting the PI3K/Akt pathway in PD-derived fibroblasts and demonstrated that HS-173 could be used as a pharmacological agent for treating other fibrotic diseases.
Article: Abstract 2063: Synergistic anticancer activity of Sorafenib in combination with HS-173, a novel PI3K inhibitor against pancreatic cancer cells.[Show abstract] [Hide abstract]
ABSTRACT: The RAF/MEK/ERK and PI3K/AKT pathways are highly implicated in the development of pancreatic cancer. The principal objective of this study was to assess the synergic effect between Sorafenib (a RAF inhibitor) and HS-173 (a novel PI3K inhibitor) to gain insight into novel therapeutic strategies for treating pancreatic cancer. We first investigated the cytotoxic effect of co-treatment with Sorafenib and HS-173 using the Calcusyn program. Combined treatment of the two drugs synergistically inhibited the viability of Panc-1 cells (combination index < 1). Concomitantly, the co-treatment induced G2/M arrest and increased apoptosis with the loss of mitochondrial membrane potential. Apoptosis resulting from the co-treatment was accompanied by increased levels of cleaved caspase-3 and PARP as well as greater numbers of TUNEL-positive apoptotic cells compared to treatment with either drug alone. Furthermore, combined treatment with these drugs decreased the expression of HIF-1α and VEGF which play an important role in angiogenesis. This anti-angiogenic effect was confirmed by the suppressed tube formation of VEGF-induced human umbilical vein endothelial cells and inhibition of blood vessel formation in a Matrigel plug assay in mice. Taken together, our study demonstrates that combined treatment with Sorafenib and HS-173 has a synergistic anti-cancer effect on pancreatic cancer cells, indicating that simultaneously targeting the RAF/MEK and PI3K/AKT pathways can induce a synergistic inhibitory effect on pancreatic cancers in which both pathways are activated. Based on the observations from our study, we suggest that the combined administration of these two drugs may be considered to be a new therapeutic regimen for treating pancreatic cancer.
Article: IPD-196, a Novel Phosphatidylinositol 3-Kinase Inhibitor with Potent Anticancer Activity against Hepatocellular Carcinoma.[Show abstract] [Hide abstract]
ABSTRACT: As the activation of phosphatidylinositol 3-kinase (PI3K) is associated with a wide variety of human malignancies, it is emerging as an attractive target for cancer treatment. In this study we synthesized a novel PI3Kα inhibitor, IPD-196 [ethyl 6-(5-(2,4-difluoro phenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxylate], and evaluated its anticancer effects on human hepatocellular carcinoma (HCC) cells. IPD-196 effectively inhibited the phosphorylation of downstream PI3K effectors such as Akt, mTOR, p70S6K, and 4E-BP1, and its antiproliferative effect was more potent than that of sorafenib or LY294002. It also induced cell cycle arrest at the G0/G1 phase as well as apoptosis by increasing the proportion of sub-G1 apoptotic cells, and the levels of cleaved PARP, caspase-3, and caspase-9. Furthermore, it decreased the expression of HIF-1α and VEFG in Huh-7 cells, and inhibited tube formation and migration of human umbilical vein endothelial cells, which was confirmed by a Matrigel plug assay in mice. Taken together, IPD-196 exhibited its anticancer activity through disruption of the PI3K/Akt pathway that caused cell cycle arrest, apoptosis induction, and inhibition of angiogenesis in human HCC cells. We therefore suggest that IPD-196 may be a potential candidate drug for targeted HCC therapy.
Article: A novel imidazopyridine derivative, HS-106, induces apoptosis of breast cancer cells and represses angiogenesis by targeting the PI3K/mTOR pathway[Show abstract] [Hide abstract]
ABSTRACT: Abnormal activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway is an essential step for the formation and growth of tumors in humans. HS-106 is an imidazopyridine derivative that inhibits the kinase activity of PI3K by binding to the ATP-binding cleft. We found that this compound suppressed breast cancer cell proliferation and induced apoptosis by specifically inhibiting the activity of target proteins in the PI3K/Akt/mTOR signaling pathway. Cell cycle analysis revealed that treatment with HS-106 resulted in cell cycle arrest at the G(2)/M phase due to up-regulation of p-cdc25 and down-regulation of cyclin B1. Also, HS-106 induced apoptosis by increasing the levels of cleaved caspase-3 and cleaved PARP. In addition, chromatin condensation and apoptotic bodies were detected in HS-106-treated breast cancer cells. Furthermore, HS-106 decreased the expression of hypoxia-inducible factor 1α (HIF-1α), and inhibited tube formation and migration of human umbilical vein endothelial cells (HUVECs) in vitro and blood vessel formation in an in vivo Matrigel plug assay. These results show that HS-106 may be an effective novel therapeutic candidate in clinical trials as a potential treatment for human breast cancers or other advanced malignancies with aberrant PI3K/Akt/mTOR signaling.
Article: HS-173, a novel phosphatidylinositol 3-kinase (PI3K) inhibitor, has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis[Show abstract] [Hide abstract]
ABSTRACT: We synthesized a novel imidazopyridine analogue, a PI3Kα inhibitor HS-173 and investigated anti-cancer capacity in human cancer cells. HS-173 inhibited the PI3K signaling pathway, and showed anti-proliferative effects on cancer cells. Also, HS-173 induced cell cycle arrest at the G(2)/M phase and apoptosis. In addition, HS-173 decreased the expression HIF-1α and VEGF which play an important role in angiogenesis. This effect was confirmed by the suppression of tube formation and migration assay in vitro. Furthermore, HS-173 diminished blood vessel formation in the Matrigel plug assay in mice. Therefore, HS-173 is considered as a novel drug candidate to treat cancer patients.
Article: Suppression of tumor proliferation and angiogenesis of hepatocellular carcinoma by HS-104, a novel phosphoinositide 3-kinase inhibitor[Show abstract] [Hide abstract]
ABSTRACT: Dysregulation of the phosphoinositide 3-kinase (PI3K)/AKT/mTOR signaling pathway frequently instigates tumorigenesis leading to hepatocellular carcinoma (HCC). We synthesized N-(5-(3-(3-methyl-1,2,4-oxadiazol-3-yl)imidazo[1,2-a]pyridin-6-yl)pyridin-3-yl)benzenesulfonamide (HS-104), a novel PI3K inhibitor, and investigated its in vitro anticancer effect and in vivo capacity in an animal xenograft model. The inhibition of cell growth by HS-104 revealed that it was effective against HCC cell lines. Also, the activation of the AKT/mTOR signal cascade was inhibited by HS-104 treatment in a dose dependent manner. Flow cytometry analysis showed an accumulation of HCC cells in the G2/M phase with concomitant loss of cells in the S phase. The apoptotic effect of HS-104 was accompanied by increased evidence of cleaved caspase-3 and PARP, as well as DNA fragmentation. In angiogenesis studies, HS-104 inhibited the tube formation of vascular endothelial growth factor (VEGF)-induced human umbilical vein endothelial cells (HUVECs), and suppressed microvessel sprouting from a rat aortic ring, ex vivo, and blood vessel formation in the Matrigel plug assay in mice. HS-104 inhibited the expression of the downstream proteins of PI3K including p-AKT, p-mTOR and p-p70S6K in VEGF-induced HUVECs. In the xenograft animal model, HS-104 significantly delayed tumor growth in a dose dependent manner and suppressed the expression of PCNA, CD34 and cleaved caspase-3 in tumor tissue. These studies show that HS-104 inhibited the PI3K/AKT/mTOR signaling pathway resulting in cell growth/angiogenesis inhibition and apoptosis induction. Therefore, HS-104 is considered as a novel drug candidate for the treatment of HCC.
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ABSTRACT: Fucoidan, a sulfated polysaccharide extracted from various brown seaweeds, possesses a wide range of pharmacological properties. In this study, we investigated the protective effect of fucoidan on acetaminophen-induced acute liver injury in rats. Liver injury was induced by administration of acetaminophen (800 mg/kg, i.p.) and fucoidan was administered (100 mg kg, p.o.) 2 h before and after acetaminophen administration. After 24 h, co-treatment of fucoidan ameliorated liver damage and cell death induced by acetaminophen. Acetaminophen induced the overexpression of CYP2E1, one of the metabolizing enzymes of acetaminophen, but cotreatment with fucoidan suppressed its increased expression of CYP2E1. Fucoidan also reduced the hepatic apoptosis induced by acetaminophen exposure as shown in the protein expression of Bax, Bcl-2, and cleaved caspase-3. The anti-oxidative effect of fucoidan was observed from the increase of the production and expression of glutathione, superoxide dismutase, and glutathione peroxidase, both of which were decreased by acetaminophen. Also, fucoidan decreased the expression of inflammatory mediators, including tumor necrosis factoralpha, interleukin 1 beta, and inducible nitric oxide synthase. Taken together, the data demonstrate the hepato-protective effects of fucoidan against acetaminophen-induced liver injury via anti-oxidant, anti-inflammatory, and anti-apoptotic mechanisms.
Article: The effect of HS-111, a novel thiazolamine derivative, on apoptosis and angiogenesis of hepatocellular carcinoma cells[Show abstract] [Hide abstract]
ABSTRACT: Hepatocellular carcinoma (HCC) is one of the most common malignancies, yet there have been no significant advances in effective therapeutics. In this study, HS-111 was synthesized as a novel thiazolamine derivative, N-(5-(2-chlorobenzyl) thiazole-2-yl) benzofuran-2-carboxamide, and its anticancer effect and mechanism were examined in human HCC cells. HS-111 strongly suppressed the growth of HCC cells in a dose-dependent manner. Also, apoptosis by HS-111 was identified by DAPI and TUNEL staining, and the increases of the cleaved caspase-3 were observed. In addition, HS-111 decreased protein expression of hypoxia-inducible factor (HIF-1α) and secretion of vascular endothelial growth factor (VEGF), and inhibited tube formation and the migration of human umbilical vein endothelial cells (HUVECs). These results showed that HS-111 not only inhibited cell growth and angiogenesis, but also induced apoptosis of human HCC cells. We suggest that HS-111 may be a potential candidate for chemotherapy against HCC.
Article: A novel imidazopyridine analogue as a phosphatidylinositol 3-kinase inhibitor against human breast cancer[Show abstract] [Hide abstract]
ABSTRACT: Potentiation of anti-breast cancer activity of an imidazopyridine-based PI3Kα inhibitor, HS-104, was investigated in human breast cancer cells. HS-104 shows strong inhibitory activity against recombinant PI3Kα isoform and the PI3K signaling pathway, resulting in anti-proliferative activity in breast cancer cells. It also induced cell cycle arrest at the G(2)/M phase as well as apoptosis. Furthermore, oral administration of HS-104 significantly inhibited the growth of tumor in SkBr3 mouse xenograft models. Therefore, HS-104 could be considered as a potential candidate for the treatment of human breast cancer.
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Inha University
Chemulpo, Incheon, South Korea
- College of Medicine
Seoul National University
Seoul, Seoul, South Korea
- College of Pharmacy


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Pattern of misconduct at TERI: Ex-employee
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New Delhi: The Energy and Resources Institute (TERI) can't give a secure working environment to its female employees, feels the woman who lodged sexual harassment case against environmentalist R.K. Pachauri in
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Odd-even scheme to be effective in Delhi from April 15-30
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New Delhi: Chief Minister Arvind Kejriwal today stated that the odd-even traffic scheme intended to curb pollution will be back in Delhi from April 15 to 30, He said three days before his AAP government completes a
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President Pranab Mukherjee condoles Lance Naik Hanumanthappa Koppad's death
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New Delhi: President Pranab Mukherjee today condoled the death of Lance Naik Hanumanthappa Koppad who passed away at a hospital here after battling for his life for two days. Lance Naik was the soldier who survived
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Lance Naik Hanumanthappa Koppad passes away at hospital in Delhi
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New Delhi: Lance Naik Hanumanthappa Koppad who was battling for his life at a hospital in New Delhi passed away today in the morning. Hanumanthappa took his last breath at 11:45 am at the RR Hospital. He was in coma
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Ishrat Jahan was a suicide bomber of Lashkar-e-Taiba: David Headley
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Mumbai: Pakistan-American Lashkar-e-Taiba terrorist David Headley's deposition via video conferencing before a special TADA court in Mumbai enters Day 4 today. Yesterday, no statement was recorded due to technical
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subset: commoncrawl


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Studio Sessions
Broken Bells On World Cafe
The members of Broken Bells, producer Brian Burton (Danger Mouse) and singer James Mercer (The Shins), met in 2004. They put out their first album in 2011 and released a follow-up, After the Disco, at the beginning of this year. Danger Mouse, who released two albums with Cee-Lo Green as Gnarls Barkley, is best known as an in-demand producer. He most recently worked on the forthcoming Black Keys album Turn Blue, as well as on the forthcoming U2 record.
The two obviously love working together, and Burton calls Broken Bells his main project. Today, we'll find out how the song "Holding On For Life" ended up with a Bee Gees falsetto. Burton and Mercer also discuss how they've been surprised by the many disco questions they've received due to the new album's name. Along the way, we also play some stellar live recordings from Broken Bells' current tour.
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One of the most difficult situations a parent can face is realising that your child or teen is being bullied at school. It can be equally difficult if your child is accused of being a bully.
Most schools are pro-active and supportive in dealing with such issues however there may be times when you feel the need to seek help outside of the school so we have provided details of some organisations who may be able to help along with articles and resources to give you guidance. You can also use our dedicated discussion board thread to seek advice and support from other parents.


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Jan 3
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Label: Deep Elm
Manager: Russ Baker
Bio: Otis was a dog who developed an extreme case of mange in his later years. This was during the same time we began the band. The smell was beyond terrible, so we'd always put him outside when we were practicing. In retrospect, we probably should have been nicer to him. Well, one day h...See Full Bio


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FLRTVC – Now with CVSS base scores!
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Video Blog: TDW - How to migrate to TDW range partition Community Blog
wangzhih Tags: wangzhih query data warehouse prune performance migrate grace pulication monitoring tdw wang range tivoli partition tool schema itm csimonitoringacademy 1,926 Views
This video will show you how to migrate to Tivoli Data Warehouse range partition. You will learn from this demo: - How to migrate your existing Tivoli Data Warehouse on DB2 to range partition, so that you can take advantage of the significant performance...
from Blog: Application Performance ManagementModified on by wangzhih
Insight on log mechanism implemented in Rational License key server Administration and Reporting tool(ART) 8.1.4.x
@Sharma~Pankaj Tags: server key reporting administration tool license rational rational-client-support 1,696 Views
In order to generate real time reports in ART tool, you need consistent and accurate data of License server logs. It is the log file that record license checkout,check-in,denial and other critical data used to generate reports in ART tool.Prior to RLKS 8142,...Modified on by AcdntlPoet
Debug Tool: No source displayed in CICS debug session
Franka Sinason Tags: tool debug_tool z/os zos systemz debug cics session 2,232 Views
No source displayed in CICS debug session. This is a problem I come across quite often. There are several steps a developer can do to resolve the issue before calling IBM for help: current program loaded is not prepared for Debug Tool This can...Modified on by SteveWebb
Coexistance of ILMT 9.x with IEM for SUA 9.x Community Blog
Silviu Gligore Tags: metric analysis endpoint software use tool ibm for manager license 2,424 Views
Hello World! :) I have had an issue the other days about using the new ILMT 9.x (IBM License Metric Tool) in parallel with IEM for SUA 9.x (IBM Endpoint Manager for Software Use Analysis). Even raised an APAR for it, APAR IV59595, raised to clarify this and...
from Blog: BigFixModified on by Silviu Gligore
What's Hot in the WebSphere MQ World? (Part 4)
Gregory(Greg)Bowman Tags: tool balancing mq mqtt hot load websphere wmq messagesight 6,132 Views
I think we are well over due for a new update on What's Hot in the WebSphere MQ World. It is Spring time here in the United States and several things have been springing up in the WebSphere MQ world lately. I think now is a good time to talk about a...Modified on by SteveWebb
IBM License Metric Tool (ILMT) services
Saurabh.Tyagi Tags: and audit reports rational the ibm ilmt tool d561hll. services unit number licensing value a in rational-client-support part metric sub-capacity processor pvu license environment 2,902 Views
One of the major initiatives many customers are pursuing is the widespread implementation of virtualization. Whether they are using virtualization purely to cut costs or whether it is part of their "green" agenda, this initiative will...Modified on by AcdntlPoet
Analyzing DataPower Latency Log
A very useful means of analyzing DataPower transaction latencies are the Latency log records (at information level), here an example: ... mpgw (coproc2xform) Latency: 0 17 0 17 20 14 11 20 22 20 22 513 0 20 17 17 [http://22.214.171.124:2223/] Paul...Modified on by SteveWebb
GraphvizFiddle Share
Troubleshoot communication problems between ITCAM Agent for WebSphere DataPower Appliance and the DataPower device Community Blog
wangzhih Tags: soma management snmp itcam soap wang appliance websphere configuration event grace xml device datapower agent wangzhih tool trap troubleshooting communication interface 2,606 Views
ITCAM Agent for WebSphere DataPower Appliance v7.1 uses multiple protocols to collect data from the DataPower appliance. How to troubleshoot the communication problems between the agent and the monitored device? Is there any tool to facilitate the...
from Blog: Application Performance ManagementModified on by wangzhih
Understanding the DataPower Multistep Probe
When using the probe it can be helpful to understand how the probe works so you can know the limitations of the feature. As an aside, when you turn on the probe on a service, this is considered a service configuration change like any other change to the...Modified on by SteveWebb
Rumo a Ferramentas mais Inteligentes
MoacyrMello Tags: ferramentas tools processamento_de_linguage... machine_learning nlp ferramenta free_software rational_tools tool ferramentas_inteligentes ferramentas_de_software aprendizagem_de_maquina open_tools 2,341 Views
O tema ferramentas de software é sempre empolgante, sejam elas visuais, completos suites ou "free" software, é comum buscar uma ferramenta melhor para atender a processos que já fazemos, e queremos deixar de fazer....
from Blog: O Mundo depende de SoftwareModified on by MoacyrMello
Jump start case management solution development with IBM Case Manager Tools Community Blog
Jackie Zhu Tags: builder icm configuration case tool ecmredbooks maanager cmac 5,478 Views
This blog post provides a high level overview of the tools available from IBM Case Manager Version 5.2 to build case management solutions. Seema Meena is a Software Engineer at the Software Group, IBM India Software Lab. She has more than 8 years of...
from Blog: ECM Community BlogModified on by Jackie Zhu
Getting Started with Rational License Key Server Administration and Reporting Tool, v8.1.4
AcdntlPoet Tags: tool rational-license-key-serv... rational licensing administration rational-client-support rational-licensing 2,731 Views
Getting Started with Rational License Key Server Administration and Reporting Tool, v8.1.4 - The new Rational License Key Administration and Reporting tool has released! Download the tool for free today, and start reporting against your usage of...Modified on by AcdntlPoet
A new way to resolve your problems in WebSphere Message Broker
Gregory(Greg)Bowman Tags: info websphere determination problem tool pdg infocenter message information wmb shooting troubleshooting broker center interactive trouble dynamic solution 5,569 Views
What is the problem? Have you ever run into a problem in WebSphere Message Broker (WMB) and you just were not sure where to start looking to find help or to find the solution? Have you ever started working on a problem in WMB and you were able to...Modified on by SteveWebb
Logic Behind TELELOGIC Licensing
Saurabh.Tyagi Tags: architect tool uml licensing point tau synergy sdl system doors modeling focal telelogic rational-client-support rational rhapsody 3,844 Views
Let's understand the concept of Telelogic based products licensing concepts. Telelogic Products: Focal Point - System for management of product and project portfolios. DOORS - Requirements tracking tool. System...Modified on by AcdntlPoet
New Rational License Key Administration and Reporting tool has released
AcdntlPoet Tags: rational-license-key-serv... rational licensing rational-licensing tool administration rational-client-support 5,213 Views
T he new Rational License Key Administration and Reporting tool has released! Download the tool for free today, and start reporting against your usage of IBM Rational Products. The reporting...
VoiCE and #IBMInnovate will unveil a new Rational Common Licensing Admin and Reporting tool!
AcdntlPoet Tags: rational-client-support innovate2013 voice tool rational innovate rational-common-licensing licensing 2,110 Views
A new IBM Rational license key administration and reporting tool is currently under development and will be showcased at both VoiCE and Innovate this year! At VoiCE , a presentation in the ED...Modified on by AcdntlPoet
Today's Video: Using the Fix Level Recommendation Tool (FLRT)
Pat_OC Tags: level totd flrt ibm_support_portal support recommendation tool electronic_support fix video portal 4,094 Views
Today's Video: Using the Fix Level Recommendation Tool (FLRT) This short, 5 minute video demonstrates the Fix Level Recommendation Tool (FLRT), which provides cross-product compatibility information and fix recommendations for IBM products. You...
from Blog: IBM Electronic Support CommunityModified on by Pat_OC
The new VIOS performance advisor tool
cggibbo Tags: 220.127.116.11 vios power7 advisor reporting vios_advisor aix chris_gibson tool part performance lpar ioslevel 14,243 Views
I updated my lab VIOS to the latest fix pack ( V22.214.171.124 ) this week and thought I'd try the new VIOS part command. This new command is an improved version of the existing vios_advisor tool. The major difference between the two is the fact that the new tool...
from Blog: Chris's AIX Blog


text:
Areas of Law
- Civil Practice
- Domestic Relations
- Criminal Law
- Real Estate
Peer Rating
Overall Peer Rating4.4 out of 5.0
No feedback is available.The individuals that have reviewed this lawyer have not provided any additional feedback.
- Meets very high criteria of general ethical standards
Experience & CredentialsPositionCounselAdmission DetailsAdmitted in 1983, Pennsylvania
U.S. District Court, Western District of Pennsylvania
U.S. Court of Appeals, Third Circuit
U.S. Supreme CourtCredit Cards AcceptedLaw School AttendedUniversity of Akron
Class of 1983
J.D.University AttendedPennsylvania State University
Class of 1976
with distinction
Gannon UniversityAssociations & MembershipsErie County (Member, Criminal and Family Law Committee), Pennsylvania and American Associations.
Community ContributionsArticles Blogs Q&A
... Read more
Legal Topics: {{legalTopic}}
Legal Topics: {{entry.aopText}}
Contact InformationFirm AddressThe McDonald Group, L.L.P.
456 West 6th Street, P.O. Box 1757,
Erie, PA 16507-0757
U.S.A.Phone814-456-5318 Ext. 126Website


text:
Kabuto Yakushi by 132JesterWatch
©2013-2016 132Jester
Holy sweet Jesus!
Creepy... yet magnificent, in a way.
Great job!
Creepy... yet magnificent, in a way.
Great job!
creepy motherfukcer.......
lol so awesome
lol so awesome
like a boss...
This is quite impressive for adding in color <3
This is epic! wow!
Ohohohohohohoho... Kabuto is so wicked... :3
ooooommmmmmgggggggggg kabuto is awsomeeeeeeeeeeee
я просто хуею с жестера
ты лучший
я просто хуею с жестера
ты лучший
exellent bro!
Utterly fantastic job, both with the lines and colors. One of my favorites I've seen in a while.
Awesome!! *-*
very great
Man! you are awesome!
Beyond coolness!
soooooooooooooooooooooooooooooooooooooooo cool!!!!!!!!!!!!
Niceee =3
Nice job
his laugh is insane and your coloring theme made it pop out very well
nice work ^-^
nice work ^-^
Absolutely magnificent!


text:
Firey Sky 2 by TheonlyAnimequeenWatch
©2009-2016 TheonlyAnimequeen
While waiting for contest winners to be announced I thought i'd upload a new pic.
So here you go. Hope you like. Favs make me happy.
So here you go. Hope you like. Favs make me happy.
wow, its really like fire and in the middle a glowing ball.
The shot is awesome, it sort of looks like it was taken perpendicular to how the sun was shining. But really, the colors are glorious and the angle is unique. Melike!
It's as if the sunset is just melting.. beautiful!
I love the few lines of black in the clouds.. really nice.
Great capture, the sky really looks on fire


text:
Dance Band | Rock Band | Cover Band | See All ▶
From Clearwater, FL
Will travel 75 miles from Clearwater
Tony Dema (Keyboard / Vocal), Tony Fiorello (Bass / Vocal), Joe Wharton (Drums / Vocal), Stephen Mason (Lead Vocalist / Keyboard), Joe Lupiani (Lead Guitarist / Vocal)
Overall Satisfaction:
Overall Talent:
They were professional in everyway....prep, set-up, performance. Jeff- Ashley N
Overall Satisfaction:
Overall Talent:
We were very happy with the Notists band. They performed their music exactly as advertised and were very friendly and easy to work with. Our corporate event was casual, and they fit right in with the evening. They also were very accommodating, playing adlib music bits that fit particular funny moments that arose from time to time during our social mixer. Of course, of big importance, was that our group, which ranged in age from 20's to near retirement age, liked the broad range of tunes throughout the decades that Notists played. We would definitely hire them again.- Dane L
Overall Satisfaction:
Overall Talent:
I hire bands monthly for our social club and was pleased to find a quality band at a reasonable price with "Notist". Our party thoroughly enjoyed the band. They had a wide selection of songs and took so many requests. This band can rock when given the green light. Be sure to turn that light on early. This is a band that will be coming back many times, hopefully. We loved the sax player who got in the midst of the crowd and wailed. Love those saxes!- ron a
Overall Satisfaction:
Overall Talent:
's Response:
At Last
Unchain My Heart
Boogie Oogie Oogie
Before He Cheats


text: The staff at Playa Bejuca house where we stayed was extremely accommodating and helpful. From our initial contact to make reservations to the day we left everything ran smoothly. The house we stayed in had everything we needed, the outdoor kitchen was very helpful as we like to cook a lot. Do know that you will need a car to...more


text:
When Jamba Juice debuted oatmeal more than a year ago, I always thought they needed to serve coffee to go along with it.
It makes sense to give customers java and Jamba Juice finally agrees. Starting Wednesday,� Jamba Juice will officially launch a line of "Hot Blends" organic coffee in most smoothie shops, including several in Orange and Los Angeles counties.
Besides drip coffee, the chain will offer a hot Vanilla Coffee Whirl and Mocha Marvel. Blended drinks can be made with your choice of organic nonfat milk, 2 percent milk or soymilk. You can also add a power boost to any drink.
Drip coffee prices: 12 oz. size, $1.80 and 16 oz., $1.95
Hot blends: 12 oz. size $2.80 & 16 oz. size $3.40
Note: Though the chain will have milk and soy milk for the drip coffee, it will not be offering "steamed" milk for specialty drinks like cafe au laits.
CLICK HERE for a list of Jamba Juice locations that will be selling coffee in Orange and Los� Angeles counties.
Oatmeal deal: To encourage customers to try the new beverages, Jamba Juice will sell oatmeal for $1 with purchase of any drink. The deal starts Sept. 8 and runs through Nov. 13.
Related stories:
[rssfeedme cat="fastfood" feedpath="/tag/jamba-juice/feed/" max="15"]


text:
Coast Coastal Landforms Amp Features
A selection of articles related to coast coastal landforms amp features.
Original articles from our library related to the Coast Coastal Landforms Amp Features. See Table of Contents for further available material (downloadable resources) on Coast Coastal Landforms Amp Features.
- Bringing it Down to Earth: A Fractal Approach
- 'Clouds are not spheres, mountains are not cones, coastlines are not circles, and bark is not smooth, nor does lightning travel in a straight line.' B. Mandelbrot W e want to think about the future - it's our nature. Unlike other creatures, humans possess an...
Mystic Sciences >> Astrology
- The Horned God in India and Europe
- Of all of the Gods that we honor in Paganism today probably the most revered is the Horned God, in the shape and form of Cernunnos. Pick up some modern Pagan literature and chances are he is in there, listen to conversation at a Moot and you will hear him...
Deities & Heros >> Celtic, Welsh, Irish & Brittish
- King James Bible: Numbers, Chapter 34
- Chapter 34 34:1 And the LORD spake unto Moses, saying, 34:2 Command the children of Israel, and say unto them, When ye come into the land of Canaan; (this is the land that shall fall unto you for an inheritance, even the land of Canaan with the coasts thereof:...
Old Testament >> Numbers
- Why are some experts skeptical about subliminal influence?
- There was once a legitimate scientific controversy over whether subliminal perception really occurs or not. The question was whether someone can perceive something unconsciously. All kinds of experiments were performed to try to prove that we were...
Parapsychology >> Subliminal Persuasion
- Sign Characteristics: Pisces
- Quadruplicity Mutable Day of the week Tuesday Birthstones Pink Coral Turquoise Aquamarine Colours Purple Grey Blue Flowers Iris Camellia Jasmine Lily Metals Tin Essences Incense Wistaria Animals Elephant Dolphin Dog GENERAL FEATURES Water sign ruled by...
Astrology >> Pisces
Coast Coastal Landforms Amp Features is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Coast Coastal Landforms Amp Features books and related discussion.
Suggested Pdf Resources
- Coastal features and processes
- Bush, D.M., and Young, R.
- www.nature.nps.gov
- ftp.wmo.int
- flux of sediments formed near the west coast of the Bakal'skaya Spit (in the northwest part of the Cri- mea) under the point of view, this spit is a free dual accumulative form of the coastal features about 8 km in length [1]. The .
- www.springerlink.com
- An assessment of the non-market value of the ecosystem services
- Oct 28, 2009 The result is a biotic homogenization of the coastal environ- benefits obtained from ecosystems, the coastal features that ... amp. B aix Ebre.
- www.upc.edu
- Search for buckling of the southwest Indian coast related to
- suggest that coastal features have changed in the past 500 yr.
- specialpapers.gsapubs.org
Suggested Web Resources
- Crickweb | KS2 Geography
- Coastal Features Jigsaw. Five photo jigsaws based on the topic of Coasts. Customize using the picture, style, number of pieces and rotation features.
- www.crickweb.co.uk
- Coastal features and processes
- Bush, D.M., and Young, R.
- www.nature.nps.gov
- Coastal geomorphology - Kay's AS & A2 Geography
- The interaction between geomorphological processes, landforms and human OSS Coastal Scene World coastlines through satellite images. . west of the county to the Wantsum Channel in the east and features erosion and management.
- www.geographer.pwp.blueyonder.co.uk
- DeHavilland Twin Otter (DHC-6)
- Electrical Two 28 VDC 250 ampere starter-generators . Surveys are conducted along the coast at 500 - 2200 feet above ground. Coastal features, stable areas , and areas vulnerable to flooding, storm surge, etc.
- www.aoc.noaa.gov
- India Geography Maps, India Geography
- In India, there is a great diversity of landforms such as lofty mountains, deep Broadly the physical features of India can be divided into five physical units The North Indian Plain, The Peninsular Plateau, The Coastal Plains, and The Islands.
- www.mapsofindia.com
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
Coast Coastal Landforms Amp Features Topics
Related searchesfrances farmer western state hospital
antonia uccello
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the crickets
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text:
Innovation Hits Home
Black Stainless
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Dynamic Duo
Cook two dishes simultaneously at different temperatures. It's one flexible oven—with two private entrances.
License to Chill
FlexZone™ is a convertible zone that transforms from fridge to freezer. Now that's fridge freedom.
Now We're
With the combined powers of convection cooking and microwave heating, your food cooks faster and more evenly.
Give Dishwashing
a Boost
Adjust water pressure and temperature with Zone Booster™—for powerful dishwashing, right where you need it.
Laundry Genius
Introducing a built-in sink for pre-soaking and pre-treating. It's called Activewash™, and it's simply brilliant.
Robot Revolution
This robotic vacuum gets astonishingly powerful suction and the digital camera-driven mapping system creates the optimal cleaning path.
Culinary Brilliance
We're proud to announce our partnership with The Culinary Institute of America to train, support and equip the next generation of great chefs.
Explore Samsung's kitchen collection inspired by chefs.See our Chef Collection


text:
Skies is a shoot-em-up game, with boats flying in the sky and a strong flavour of adventure.
Mandatory bullet points :
Feature Details:
Game: QuestRun (Alpha)
Developer: Cuve Games
Featured Charity: Médecins Sans Frontières
10% of all sales generated by this deal will go to the featured charity.
Platforms: Windows, Mac
DRM & Distribution: DRM-Free, Desura
Controller Support: No
Game Description:
"You love RPGs but you don't care about dialogues and scenarios? QuestRun is for you! Run through various dungeons in this tactical fast-paced game, try to go as far as you can with your heroes, die in agony and try again! Try new strategies, new heroes, choose new perils, and die anyway! Discuss your unfair death with your friends or complain on a forum! That's what we aim for!"
"Skies is a shoot-em-up game, with boats flying in the sky and a strong flavour of adventure"
Skies v1.1.2 - and now the game is downloable through the Desura App
Skies is available ! Only 36h left to get it 50% off ! Read this also if you have problems with installation
Skies is available for pre-order ! The game will be released on the 5th of June.
No articles were found matching the criteria specified. We suggest you try the article list with no filter applied, to browse all available. Post article and help us achieve our mission of showcasing the best content from all developers. Join now to share your own content, we welcome creators and consumers alike and look forward to your comments.
Really like the game,but I would also want to play in fullscreen if possible? :)
Hello dear player,
We might include the feature in a future update !
There seems to be an issue with some players who download the game via Desura app. You can download it directly from the site if it is the case. We definitely going to look into the problem soon.
Sorry about that !
Hey guys, its almost a month since you posted that and you still havent fixed it. Whats the current state on the issue?
Your problem should be fixed with the version 1.1.2 which is available. Did you try to install it through the Desura App ?
I just downloaded it on the Desura app and got an error about the game not working, redownloaded the same files via Desura app again and same error. Now I installed the .exe that is available via the website and had the Adobe installer thing running to start that extra file. Once the game installer from the Website was done, the game also started working via the Desura app. Does the website version include a framework installer or something thats not included in the Desura app? Cant provide you with any information anymore either since its working from my app now, but something is still not working correctly apparently.
Yeah the game needs Adobe Air but the Desura App should have asked you to install it. That's weird and there's nothing more we can do on our side. Glad it worked for you though
Well good for you that its not a serious issue, but it doesnt hurt to be aware of it I guess. Good luck with this and any future games :)
is there a possibility to change to fullscreen? The window is tiny.
Hello dear player,
It's not possible with the current version. We definitely going to try to include the feature in the next update !
its not working on my desura, it just keeps telling me its broken.
i had the same problem and you probably need to uninstall adobe air and reinstall it
here is the link Get.adobe.com
That worked, but now I have an issue where on a mission where I am escaping from an enemy fleet to the first city, My ship dosent appear on the screen and I can get killed but can kill them and if I stay alive for too long the game freezes.
Hello dear player,
From what you describe, I think you are playing the mission in which you control another ship. If you're looking for your usual ship, you're doing it wrong ! The civilian ship you control can't shoot, that's the whole challenge.
Good luck !
.....Sorry I meant I can die but I cannot either see nor kill the enemy.
Nor can I see any ship I am controlling, the only things that appear are the smoke trails of the ships and thats it.
Dear player,
The issue you encountered with the invisible ship has been fixed in the patch 1.1.2.
Have a nice day !


text:
Parklane Hotel
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
- Restaurant
- Room service
- Swimming pool
- Business Services
- Bar/lounge
Photos of Parklane Hotel
Travelers also looked at:
TravelPod Member ReviewsParklane Hotel Mysore
What can I say it's a good place to stay and catch some sleep, have good food in the cafe and be close to central Mysore. It is not fancy but basic and serves the needs of the traveler looking for a place to stay without spending to much.
This review is the subjective opinion of a TravelPod member and not of TravelPod.com.
Really nice hotel for a decent price. Lots of amenities and good restaurant.
This review is the subjective opinion of a TravelPod member and not of TravelPod.com.
Adjacent to Mysore Palace, with good service, our room was clean and adequate, the popular terrace restaurant has a sliding roof, with stars above at night, power points to charge kit, and Indian music for a couple of hours each evening. The food is fine and reasonably priced, with the bill arriving in a shiny metal box. We didn't try the swimming pool on the roof.
This review is the subjective opinion of a TravelPod member and not of TravelPod.com.
The room was fine. The pool is very very small and quite dirty and there is no place to sun tan (they hang laundry up there). It was an ok place to stay but over priced at 1800 ruppees/ night (w aircon).
This review is the subjective opinion of a TravelPod member and not of TravelPod.com.
TripAdvisor Reviews Parklane Hotel Mysore
Travel Blogs from Mysore
Raj Palace, Woodworkers, Beedies & Essential Oils
February 21, 2015
THOLPETTY (Kerala) to MYSORE (Karnataka) 126km
Parklane Hotel - 2100Rs/$34, deluxe, AC, without breakfast
Gaur, Elephants and Spotted Deer
After breakfast, we said goodbye to the Swedish family. They had arranged a car and driver to take them to Kunnar, on the Keralan coast, where they will spend …
Away for an early start from Kalpetta - the bus journey to Mysore takes over 4 hours - we were lucky that a bus to Bangalore (via Mysore) arrived just after we got dropped off at the bus stop.� It looked quite an old bus but it turned out to be an unexpectedly comfortable ride.� The bus was less than half full for most of the trip and we spent a …
Trip to Srirangapatna
... main burial chamber, which belong to other members of the family. The Gumbaz is flanked by a mosque and a low-ceiling arched hall. Besides this, horse-rides are available outside the Gumbaz.
Following the Gumbaz, we went to Tipu Sultan's Summer palace or the 'Dariya daulat Bagh' (the wealth of the sea). Built on a raised stone platform, this two-storey palace is mostly made of wood with intricate paintings ...
Last Full Day: Mysore, or I'm not a pothead
... as we have done the past two days; I pull up a mat and sit maybe a metre and a half from her, and she sits upon the bed with her feet and spine adhering to the lotus posture. We go over it a total of 28 times (this must be an auspicious count, though I'm still unaware of why). The first 10 I read directly from the printout at my feet, the remaining 18 I do blind, relying wholly on a steady rhythm and Jayashree's voice. We count each recitation using our right thumbs and ...


text:
The Leading eBooks Store Online
for Kindle Fire, Apple, Android, Nook, Kobo, PC, Mac, BlackBerry...
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The Ju/'hoan San of Nyae Nyae and Namibian IndependenceBerghahn Books 2010; US$ 34.95
The Ju/'hoan San, or Ju/'hoansi, of Namibia and Botswana are perhaps the most fully described indigenous people in all of anthropology. This is the story of how this group of former hunter-gatherers, speaking an exotic click language, formed a grassroots movement that led them to become a dynamic part of the new nation that grew from the ashes of... more...
London LivesCambridge University Press 2015; US$ 26.00
Surveys the lives and experiences of hundreds of thousands of eighteenth-century non-elite Londoners in the evolution of the modern world. more...
The Marengo Jake StoriesUniversity of Alabama Press 2009; US$ 29.95
Between 1885 and 1894 The Montgomery Advertiser, The Birmingham-Age Herald , and The New Orleans Times Democrat featured a series of about 80 humorous black-dialect sketches by Robert Wilton Burton, a bookseller and writer from Auburn, Alabama. According to Burton, these tales were based on various characters in the black community of Auburn,... more...
Vulnerable ChildrenSpringer New York 2014; US$ 149.00
Covering millions of young victims of war, poverty and disease, who are deprived of home, family and basic human rights, this book analyzes current intervention programs and identifies challenges that must be met in the community and at broader policy levels. more...
Transitional JusticeRutgers University Press 2010; US$ 27.95
How do societies come to terms with the aftermath of genocide and mass violence, and how might the international community contribute to this process? Transitional Justice, the first edited collection in anthropology focused directly on this issue, argues that, however well-intentioned, transitional justice needs to grapple more deeply with... more...
The Historiography of GenocidePalgrave Macmillan 2008; US$ 33.00
The Historiography of Genocide is an indispensable guide to the development of the emerging discipline of genocide studies and the only available assessment of the historical literature pertaining to genocides. more...
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Galleries: Robin Thicke And His Lil Laker Fan, Gabrielle Union At BET Honors, John Legend And Chrissy Coupled Up- By Bossip Staff Categories: Babies, Ballers, Bangers
John Legend and his lady love Chrissy Teigen had a night on the town in Hollyweird. The couple dined at Spago and were also seen leaving a party at Bar Marmont.
Check out her engagement sparkler. Must be nice!
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George introduces his girlfriend, Eden (Alicia Silverstone), to Tessa; Noah and George make a deal; Sheila's meddling overwhelms Eden.
George becomes smitten with a woman he meets at the farmer's market; Tessa and Dalia search for a missing Yakult; Noah and Jill make an announcement.
While Tessa tries to adjust to living with Eden, George takes issue with Eden's parenting; Lisa and Malik consider which camp they should attend.
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There's an article [1] in the New York Times about a trend in middle and high school education--dropping assigned, classic texts and letting kids read pretty much whatever they want, including "James Pattersons adrenaline-fueled 'Maximum Ride' books, plenty of young-adult chick-lit novels and even the 'Captain Underpants' series of comic-book-style novels."I tend to be a tad crusty on issues like this--as in, "this is another sign that the Apocalypse is upon us"--but as a parent and a teacher I know the exhausting struggle of wills with students these days when it comes to asking them to read something. Anything.So I do have brief moments when I think "let them read anything--the back of a Honey Nut Cheerios box--at least that may help get them in the habit of reading."But, back on the crusty side again, I think: "This is the death of authority and the triumph of consumerism."To read something because your teacher thinks it's a good idea--this is now oppression?In fact, I suspect that the most powerful force at work here is not postmodern attacks on authority but simply the siren song of pragmatism--"in the age of Twitter they won't really read or engage 'Huckleberry Finn' so they should at least choose to read 'Captain Underpants.'I don't buy it.A good teacher should be able to fire up any class for a great text. Part of the teacher's job description is learning how to overcome resistance. In a word, to generate the right set of circumstances for the secular equivalent of a conversion experience.For me it happened in the eighth grade during what seemed like an interminable line-by-line slog through Julius Caesar. One day I was full of fear and loathing; the next I was intoxicated and in love. I don't think this could have happened without that slog. (Thank you, Mr. Taussig!)Teachers, don't despair. Do not abandon your teaching authority. Challenge them to read the good stuff. Literary metanoia can still take place.
Links[1] http://www.nytimes.com/2009/08/30/books/30reading.html?_r=1&hp
[2] https://www.addthis.com/bookmark.php?v=300


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WRS Series consists of conveniently sized tank and pump combos; ideal for impractical gravity drainage areas such as under sinks and laundry trays.Product Features:
- 1/6 Horse Power with overload protection
- New cooler running motor which extends the life of the pump
- Designed for continuous duty
- Covered by 12 month limited warranty
- Does not handle solid particulates
- Cover made from: Cast aluminum
- Housing made from: Cast Aluminum
- Impeller made from: Nylon
- Switch Type: Diaphragm
- Single phase operation
- 10' Cord included
- UL/CSA listed
- 1/6 Horse Power
- Voltage: 115V
- 5 Amp maximum operation
- 1-1/2" Discharge diameter
- Length: 14-1/2"
- Width: 14-1/2"
- Height: 15-3/5"
- Flow rates (GPH: gallons-per-hour):
- At 5 feet of head: 900
- At 10 feet of head: 690
- At 15 feet of head: 480
Additional Little Giant Links
This Little Giant item can also be referenced by the following color/finish specific model #:
- Little Giant 505055
*Discontinued model or finish
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Discover the best online deals for the 505055 and everything else for your home from the leading online home improvement store.
We're committed to providing you with the best assortment of Little Giant products with over 400 warehouses across the country.
Our knowledgeable product specialists work to bring you the best prices on every product and provide unmatched customer service. Your satisfaction is our highest priority!
Manufacturer Resources
Installation Resource Center
Whether you are installing the product yourself or hiring a professional, our installation Resource Center has everything you need to get your project done. Visit the Installation Resource Center to get started.


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Inspire Girl
Welcome to InspireGirl! I love anything inspirational, vintage, or artistic. I appreciate all forms of creativity and would love to support you with treasures or supplies that will help you to achieve your creative vision. I look for items that can be used in any way your imagination takes you. Check often to see what my… read more
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RONALD BOLDIN, OL 6-6, 270, Pahokee, FL (Pahokee)- Excellent athlete with the speed to play on the defensive line and the athletic skills and strength needed on the offensive side ... actually began playing varsity football in the seventh grade and has started since his freshman season ... led Pahokee to the state semifinals ... ran a 5.0 in the 40 ... has a 300-plus pound bench press, while squatting 465 ... named to the Class 3A all-state second team for the second consecutive year ... Forrest Davis labeled him as an impact player, receiving all five stars ... named to the Sunkist/Forrest Davis All South first team ... also listed among Davis' Florida Top 12 ... received a 9.5 on a 10-point scale from Jeff Whitaker's Deep South Football ... named All-Southeast, receiving a 5.7 on a 6.1 scale by the National Recruiting Advisor ... listed on Jamie Newberg's "Border Wars Top 100 "...selected All-Regional and rated as the No. 37 prospect in Florida by SuperPrep ... rated among the top 20 offensive lineman in the southeast by PrepStar ... earned honorable mention USA Today All-USA honors ... listed among the top 100 nationally and No. 22 in the Southeast by Tom Lemming ... listed No. 18 in the Tampa Tribune's top 50 state recruits and No. 82 in their top 100 nationally ... checks in on St. Pete Times Blue Chip list at No. 25 ... also listed on the Tallahassee Democrat Top 50 and Florida Times- Union Super75 ... chose FSU over Ohio State, West Virginia, Auburn and Michigan State.
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- ParaguayRetailFunding via Fundación Paraguaya
Esperanza G...ParaguayRetailFunding via Fundación Paraguaya
ZulliParaguayRetailFunding via Fundación Paraguaya
San Cayetano Group
Crisolina is the president, and a member of the group, and she has a small snack shop where she sells foods, drinks, candies and more. She says that she began with a small business and thanks to sacrifice and daily hard work she has been able to grow her business and continue to improve it. She is asking for a loan to purchase candies and drinks in order to stock her business and be able to continue to work in this line of work.
Crisolina es la presidenta y miembro del grupo, quien tiene un pequeño copetín donde vende alimentos, bebidas, golosinas y demás. Comenta que empezó con un pequeño negocio, y gracias a su sacrificio y trabajo diario ha podido ir creciendo y mejorando. Ella solicita el crédito para la compra de golosinas, y bebidas, para poder surtir su negocio y seguir de esa forma trabajando.
Additional Information
About Fundación ParaguayaFundación Paraguaya is a financially self-sustaining social enterprise that promotes entrepreneurship in urban and rural areas through microfinance, education programs, and more. Its focus on agriculture has helped many farmers boost their crop yields. And a number of other borrowers have taken out loans to start and grow social businesses that have helped deliver eyeglasses, medicines and other helpful services in their local communities.
This is a Group Loan
In a group loan, each member of the group receives an individual loan but is part of a larger group of individuals. The group is there to provide support to the members and to provide a system of peer pressure, but groups may or may not be formally bound by a group guarantee. In cases where there is a group guarantee, members of the group are responsible for paying back the loans of their fellow group members in the case of delinquency or default.
Kiva's Field Partners typically feature one borrower from a group. The loan description, sector, and other attributes for a group loan profile are determined by the featured borrower's loan. The other members of the group are not required to use their loans for the same purpose.
About Paraguay
77View loans »
Success!! The loan was 100% repaid
- Repayment Term
- 6 months (Additional Information)
- Repayment Schedule
- Monthly
- Pre-Disbursed:
- May 17, 2012
- Listed
- Jun 15, 2012
- Currency Exchange Loss:
- Covered
- Ended:
- Oct 15, 2012


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Stein Zupancic Viking STOCK 02 by DiamonEyesWatch
©2012-2016 DiamonEyes
Need a rough, buff, Viking-lookin dude for your next project? Then consider checking out this raw version of Stein Zupancic's "Ruffian Sex Appeal."
Rules for Using
Please let me know that you'd like to use this image beforehand.
Please credit Stein Zupancic and myself for the image stock.
Please do not use for any hate-supporting topics/inappropriate imagery. If you have any questions on whether your project falls in those lines and want to seek permission, feel free to note me and I'll see what I can do to help
Let me see the final product!
And most importantly, HAVE FUN USING IT!!!
Completed Version:
Personal Example of Photomanipulation:
Ominous Duke of the underworld
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Thank you for your deviant submission
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tenchibaka.deviantart.com/art/… it's crappy art but i wanted to see if i could since i had been feeling better, i got my answer x___x
It's very scary how closely he resembles my boyfriend... @_@
REALLY? Is that good or bad?
Well, I'm not sure really!! Some of these shots the model has a very intimidating look on his face and it's a bit unsettling for me! Usually my boyfriend has a sweet smile on his face (when he's looking at me at least) and only has this look when he's angry. Other than that.. the only difference between Stein Zupancic and my man is the color of eyes and tattoos... and mine has let himself go a little bit, but when he was in shape he was heavier-built from being in wrestling.
He's got those "Honey-colored" eyes
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Damn this is stylish!


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Veritek Single Laundry Tub with White Legs and Drain Installed 23.375" D x 22.875" W
When it's time to get busy, Swan's utility products and accessories are ready to go to work. Our selection of laundry tubs, service sinks and shower cabinets offer you solutions that are strong, practical and performance-minded.
Veritek is Swanstone's affordable compression-molded material with no surface coating to chop or crack. This non-porous material will not mold or mildew, so it is perfect for your bath, laundry and utility rooms. Choose from bathtubs, bath and shower walls, shower floors and utility sinks and basins. Veritek products are covered with the industry's best warranties.
Swanstone MF-1PF Features:
- 4 angular white legs
- Pre-drilled 4" centers
- Installed drain
- 22 gallon capacity (83L)
- Molded-in wash board
- Made of sturdy Veritek with no surface coating to chip or crack
- Will not mold or mildew
Additional Swanstone Links
This Swanstone item can also be referenced by the following color/finish specific model #:
- Swanstone MF-1PF*
*Discontinued model or finish
More Than Just a Store - Your Reasons to Shop
Discover the best online deals for the MF-1PF and everything else for your home from the leading online home improvement store.
We're committed to providing you with the best assortment of Swanstone products with over 400 warehouses across the country.
Our knowledgeable product specialists work to bring you the best prices on every product and provide unmatched customer service. Your satisfaction is our highest priority!
Manufacturer Resources
Installation Resource Center
Whether you are installing the product yourself or hiring a professional, our installation Resource Center has everything you need to get your project done. Visit the Installation Resource Center to get started.


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How to Decalcify Your Pineal Gland
- Uploaded by Goldy on Nov 11, 2012
- Views: 1047
Twitter: http://twitter.com/erinjanus *Facebook: http://bit.ly/erinsFB *Subscribe for more videos from me :)These are just a few things you can do to decalcify & nourish your pineal gland. I recommend you make your own notes, research and come to your own consensus."Keep the pineal gland operating and you won't grow old -- you will always be young". Edgar CayceFeel free to inbox me if you have any requests for future videos.A big thanks to Jorge for opening my eyes... I mean... eye. In a distant past our pineal gland used to be our third eye and, even more than an eye: a cosmic receiver and sender of multi-dimensional information. The pineal gland is now a tiny gland in the centre of our brain, connected with all our senses and the rest of our body. Through the other senses it communicates with the outer world in electrical impulses.With its spectrum of hormones it regulates our state of consciousness, e.g. waking, sleeping, dreaming, various meditative states including those states in which we may have mystical experiences. The mind and senses are paths for occult energies that work through various psychophysical centers or chakras, among the highest of which is the pineal gland. These centres continue to develop as we evolve towards spirit.So, while the third eye or pineal gland has certain physiological activities in conjunction with the pituitary gland - together they regulate the rhythms of metabolism and growth - it is also the physical organ of intuition, inspiration, spiritual vision, and divine thought. The pituitary gland is the thought receiver and the pineal gland, often called our true master gland, is the thought transmitter. The pineal gland is the very key to the highest and divinest consciousness in man - his omniscient, spiritual and all embracing mind. It is the Single Eye. The more light you can store in your body, the higher your vibration will become. The higher your vibration is, the easier it becomes to elevate your surrounding as well as the people around you. Now is the time to reawaken our pineal gland as a cosmic antenna.http://thelightproject.blogspot.ca/2006/04/pineal-gland-our-cosmic-antenna.htmlLike Crystals?Healing Crystals - A Metaphysical Crystal Storehttp://www.healingcrystals.com/index.php?ref=218&affiliate_banner_id=2


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Goodhew Awning Stripe Micro Socks - Women'sView Larger Image
It's simple, the Goodhew Women's Awning Stripe Micro Socks are just plain comfortable no matter what you're doing or what shoes you're wearing. Naturally soft and breathable merino wool adds a touch of luxury, and a blend of synthetic materials allows these socks to stretch to match the natural shape of your feet. Goodhew pays attention to the tiniest details so these socks take care of your feet from your heel right to the tip of your toes.
- Merino wool material is naturally breathable, soft, and itch-free
- Blend of synthetic materials allows this sock to dry quickly and lends it a flexible stretch and long-term durability
- Light cushioning absorbs impact underfoot and takes the bite out of long days spent on your feet
- Turn welt top sits flat and comfortably against the inside of the instep of a running or casual shoe
- Y-heel construction creates a small pocket to keep the heel in place without sliding around
- Flat toe seam eliminates the seam bulge that can easily rub and cause discomfort at your toes
- Reviews
What do you think about this product?
Have questions about this product?
These a my fav
- Familiarity:I've used it several times
- Fit:True to size
- Size Bought: large
I love these socks! They are so soft, and cushiony. Even in the summer my feet stay comfortable with no sweating.


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…The acceptance of DNA fingerprinting as evidence by the courts should be seen as yet another milestone in the evolution of this technology in the country…
PowerPlex® 6 color Fusion System is here!
Coming Soon!
PowerPlex Y23
Cycling time of less than 50 minutes saves hours
The power to see it all in a single assay!


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Cash Equivalents and Fixed Income Securities - Yield Curves
Ayield curve is simply a graph that plots bond yields against their time period to maturity. The curve will show whether short-term interest rates are higher or lower than long-term rates.
- Normal Yield Curve
- Most of the time, the yield curve will be positively sloped, which means lower interest rates are correlated with shorter maturities.
- As maturity lengthens, interest rates increase.
- For instance, if two-year Treasury notes yield 3%, five-year Treasury notes yield 4% and 10-year Treasury bonds yield 5.5%, then the yield curve will be sloped positively. This would be a normal yield curve.
- The following diagram is of a normal yield curve, exhibiting a positive slope.
- Most of the time, the yield curve will be positively sloped, which means lower interest rates are correlated with shorter maturities.
|Figure 9.1:
- Inverted (or Negative) Yield Curve
- Occurs when there is weak demand for bonds with short maturities, which drives yields up, while a strong demand for long-term bonds drives these yields down
- An inverted yield curve means short-term interest rates are higher than long-term rates. This is an unusual situation, but it does happen.
- An inverted yield curve may be an indication of economic decline.
- An inverted yield curve would result if the two-year Treasury note yielded 3%, the five-year Treasury note 2.75% and the 10-year Treasury bond 2.5%.
- This would occur if rates were high but expected to fall.
- The following diagram represents an inverted yield curve.
- Occurs when there is weak demand for bonds with short maturities, which drives yields up, while a strong demand for long-term bonds drives these yields down
Figure 9.2: Inverted Yield Curve
- Flat Yield Curve
- Occurs where yields are the same for short-, intermediate-, and long-term bonds.
- This type of curve is a rare occurrence.
- The flat yield curve is essentially a flat line.
Figure 9.3: Flat Yield Curve
Look Out!
Generally, questions about yield curves relate either to demand or to where interest rates are heading based on the current curve. Read these questions carefully, since one of the incorrect choices may refer to where interest rates are at the time of the yield curve.
Yield Spreads
This refers to the difference in interest rates between different classes of bonds. For example, corporate bonds always have a higher yield than government bonds due to their higher risk. However, the spread is not constant - it can fluctuate over time based on factors such as:
- Investor expectations about the economy
- Issuer activity when a larger or smaller than usual amount of Treasuries is issued, it affects supply, which can affect yields and spreads
- Institutional investors (such as mutual funds or pension funds) heavily buying or selling a particular type of bond, which can also affect supply. and thus spreads
Exam Tips and Tricks
You might encounter a question like this on the exam:
If a bond is bought at a discount, the yield to maturity would be:
- The same as the nominal yield
- Lower than the nominal yield
- Higher than the nominal yield
- Not enough information to determine the answer
Corporate Bonds
The correct answer is "c" - since the buyer paid less than par, the yield to maturity will be higher than the nominal yield.
The Basics of The Series 79 ExamPassing the Series 79 exam is usually necessary for anyone who wants to work in investment banking.
What is the Series 66?The Series 66 exam is one of two tests required to register as both a securities agent and an investment advisor.
Breaking Down Financial Securities LicensesFind out which exam you need to begin your career as an investment professional.
Career Advice: Financial Analyst Vs. Investment BankerRead an in-depth comparison about working as a Financial Analyst vs. working as an Investment Banker, two highly prestigious business careers.
Who Needs to Take the Series 65?Most states require individuals to pass the Series 65 exam in order to act as investment advisors.
Personal Finance
RIAs and Brokers: What's the Difference?RIAs and brokers are held to different standards when providing investment advice. Here's how they differ.
Investing Basics
Brokers and RIAs: One and the Same?Brokers and registered investment advisors have some key differences. Here's what you need to know.
Understanding Series 6Upon successful completion of the Series 6, an individual will have the qualifications needed to sell open end mutual funds and variable annuities
Top Strategies on How to Become a Stock BrokerGunning to be a stock broker and want an edge? Here's some veteran advice.
Trading Systems & Software
Steps to Starting Up an Independent Broker DealerLaunching your own broker-dealer is a lot of work, but the potential payoff is great, both personally and financially.
Series 6A securities license entitling the holder to register as a limited ...
Series 79A examination to ensure a candidate is qualified to become a ...
Research AnalystA person who prepares investigative reports on equity securities. ...
Series 34An exam required for individuals seeking to engage in off-exchange ...
Financial AdvisorOne who provides financial advice or guidance to customers for ...
Series 28An exam given by the Financial Industry Regulatory Authority ...
Is a financial advisor required to have a degree?Financial advisors are not required to have university degrees. However, they are required to pass certain exams administered ... Read Full Answer >>
Do financial advisors have to be licensed?Financial advisors must possess various securities licenses in order to sell investment products. The specific products an ... Read Full Answer >>
If I have only a limited amount of time to study for the Series 6, what should I ...The Series 6 Investment Company and Variable Contracts Products Representative Qualification Examination is administered ... Read Full Answer >>
What role does the 'chip cycle' play in the electronics sector?There are several highly acclaimed private Series 6 Exam courses in the United States. Many can be completed online. Popular ... Read Full Answer >>
What does passing the Series 6 enable me to do?The Series 6, or the Investment Company Products/Variable Contracts Limited Representative, exam is administered by the Financial ... Read Full Answer >>
What are the differences between the Series 6 exam and the Series 7 exam?The Financial Industry Regulatory Authority (FINRA) offers a variety of licenses that must be obtained before conducting ... Read Full Answer >>


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- Have any questions? Email firstname.lastname@example.com or send us a message through eBay and we will get back to you as soon as possible.
This image is for illustration purposes only.
Wezmoto Full Length Race Braided Brake Lines Ducati 999S 2005-
- 2
- 1
- Smoother & Stronger Braking
- Eliminate 'Spongy' Brakes
- Sharper and More Responsive Braking
- More Reliable Braking System
Hose Colours
Full Length Race Layout
The kit comprises of two lines for the front of the bike which both travel from the master cylinder direct to the left and right front calipers. This kit also includes one rear line.
Wezmoto performance brakelines are made from a stainless steel braided hose with a Teflon inner hose which is coated with protective plastic sleeve which helps protect your paintwork from scratches and enhances the look of your bike. All our fittings are full Stainless Steel, not Zinc Plated.
You can also choose the colour of the stainless steel banjos from; Plain Stainless or Black.
Fitting this kit will bring much improved braking, eliminating that mushy feeling of rubber hoses, up to 60% less expansion than the standard rubber hoses, will never fade due to heat build up and reduce brake lever travel which creates faster braking power and a much improved feel.
If you have added handlebar risers or extended your rear swingarm, we will add the extra length absolutely free! Just tell us how much longer you need it when ordering.
Remember when ordering to include a note of which colour hose & banjos you require, and the model or year of manufacture of your bike.
- High quality, 100% stainless steel, non-corroding braided brake hoses
- SAE J 701 (Worldwide), FMVSS-106 (Europe), ADR (Australia), LTSA (New Zealand) and DOT (United States) Approved
- Braided Brake Lines used in MotoGP and BSB
- Coated in a wipe-clean PVC cover
|Stainless Steel Braided Brake Lines
|Stainless Steel Banjo Bolts
|Copper Crush Washers
|Instruction Leaflet
|Lifetime Warranty
We only accept PayPal as our payment method. It is the safest most effective way of paying for your goods on eBay and gives you total peace of mind.
All our kits are made to order and sent within 2 working days via Royal Mail Signed For. You will be sent a tracking number as soon as your parcel has been dispatched. Royal Mail say this service can take up to 7 working days to arrive.
Please contact your local post office if you have not received it in this time as it is very often sat waiting to be collected.
A signature is required for this items delivery.
Outside the EU, import duties may be charged on this item and you are responsible for those costs should they be applied.
This item is exempt from EU Distance Selling Regulations as it will be custom made to order in your choice of colours. Please Double Check you are ordering the correct item for the Exact Model of motorcycle as it is NON RETURNABLE. In the unlikely event of a faulty item, it will be replaced.
You are responsible for the cost of the return postage.
All Wezmoto performance brakelines come with a lifetime warranty against faulty manufacture. We operate very strict manufacturing checks to ensure the safety and quality of our products.
About Us
Wezmoto EU are a family run manufacturing company operating in the UK specifically for the internet & eBay marketplace. We have been involved with brakelines for over 6 years and are gradually building a name for ourselves through our attention to detail and the quality of our products.
Our performance hose kits are made under license to a leading UK manufacturer.


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Acronyms that contain the term saba
What does saba mean? This page is about the various possible meanings of the acronym, abbreviation, shorthand or slang term: saba.
We've found a total of 5 shorthands for saba:
Filter by: Sort by:PopularityAlphabeticallyCategory
Gulf Colorado and San Saba Railway
San Saba County Municipal Airport, San Saba, Texas USA
Saba, Netherlands Antilles
San Saba, TX
Saba-Yrausquin, Netherlands Antill
What does saba mean?
- Saba(noun)
- a island in the Netherlands Antilles that is the top of an extinct volcano
Still can't find the acronym definition you were looking for? Use our Power Search technology to look for more unique definitions from across the web!
"saba." Abbreviations.com. STANDS4 LLC, 2016. Web. 9 Feb. 2016. <http://www.abbreviations.com/saba>.


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OP3NvoiceKnow more faster
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Wir bieten attraktive Leistungen.
We love great food
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We <3 Apple
Work in a retro warehouse in East Austin
Happy co-work family culture (without the stress)
2nd monitor


text: MTV Multiplayer: "StarCraft 2: Wings of Liberty" is a daunting thing to review. Between the legacy of its 12-year-old predecessor as the greatest real-time strategy game of all time, the anticipation fueled by more than a decade of waiting for a follow-up and the incredible depth on offer in the now-released sequel… well… really, "daunting" becomes something of an understatement. -