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An Awl by any other name!
By pasojanice
from Wellsboro, Pa
About Me Casual Do-It-Yourselfer
See all my reviews
Comments about Central-Forge 4 In. Scratch Awl:
I was looking for this so that I could use it in leather crafts. As usual, Harbor Freight came through with just what I was looking for and at a very reasonable price. No problems, got it home and used it right away. Good, clean hole and no 'extras'. Just what I wanted! Thank you.
Bottom Line Yes, I would recommend this to a friend
Was this review helpful? Yes / No
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Comment on this review
A very useful tool
By Churchill B
from Maine
About Me Professional
This awl is sturdy and does a good job of poking holes in this stuff or that. Use it for scratching and scribing, sure - those are the easy ones. We also use it for poking holes in leather before hand stitching and for making small starter holes for square shank nails when repairing antique steamer trunks. This tool can do it awl. Rim shot. I'm here all week - try the roast moose; it's fabulous.
"Love this thing"
By taz
from az
great for punch holes in the sheet rock for anchors
(2 of 2 customers found this review helpful)
best around tool
By joe
from rogers, mn
I use this to mark metals that have to be machined. Strong lines and can be seen clearly. better then the other guys.
It does the job
By niclo
from Saint Louis, MO
Not the most comfortable because the grip is sort of small. But it works fine for me.
Pretty Good, Buy Some Glue Also
By The Dude
from St. Louis
It's true that the ferrule fell right off after opening the packaging; and it's also true that gluing it back on with wood or poly glue works well and keeps that little sucker on there. Other than that, it's an awl, it scratches things ... that's pretty much what it needs to do to obtain a good rating; it just needs that little bit of love up front and it's ready to use.
Fell apart when removing from package
By RiverFish
from Dallas, TX
About Me Avid Do-It-Yourselfer
When I opened the package the ferrule slid right off and onto the floor. A little wood glue and a shim fixed it right up so I kept it. No other problems, works as designed.
Most orders will be processed and leave our warehouses within 1-2 business days from the time your order is placed. Orders placed on Saturday or Sunday will be processed on Monday.
*Overweight items are shipped via freight delivery, please allow up to 15 business days for shipping. Standard Ground Shipping rates apply to deliveries within the continental Unites States.
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Harbor Freight Tools does not endorse any other business or organization or any technique in any customer and/or fan video. Always follow all of the instructions and warnings included with our products. We make no representation or warranty of any kind by including any customer and/or fan video on our website.
LIFETIME WARRANTYLifetime Warranty on Hand Tools! We guarantee our Hand Tools to be free from defects in material and workmanship for the life of the product. Limitations apply.
ABOUT HARBOR FREIGHT TOOLSFounded in 1977, Harbor Freight Tools is the leading discount tool retailer in the U.S. selling great quality tools at "ridiculously low prices" in over 600 stores nationwide and on its website www.harborfreight.com. Harbor Freight Tools stocks over 7,000 items in categories including automotive, air and power tools, shop equipment and hand tools. With a commitment to quality and a lifetime guarantee on all hand tools, Harbor Freight Tools is a favorite of automotive and truck repair shops, government agencies, schools, manufacturers, contractors and tool enthusiasts who want top-quality and great selection and value. The results speak for themselves - with over 30 million customers and thousands of people switching to Harbor Freight Tools every day.


text:
This profile was last updated on 12/19/13 and contains information from public web pages and contributions from the ZoomInfo community.
Mr. Chris BuckmanWrong Chris Buckman?
Business Development Manager
Phone: (316) ***-****Email: b***@***.com
Local Address: Wichita , Kansas , United States
Sysco Corporation
1390 Enclave Pkwy
Houston , Texas 77077
United States
Company Description: Sysco Corporation (Sysco), along with its subsidiaries and divisions, is a North American distributor of food and related products primarily to the foodservice or... more
ProPub_Iteration_NoTests.312[05] SEIDXWK-6

subset: commoncrawl


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ESPN's cameras will be on hand for the prime-time telecast
(7:00 PM ET) that finds New York
knuckleballer R.A. Dickey opposing McClellan. Early morning MLB odds have the Mets slight favorites around -110 at
most MLB books with an 8.5-run total.
Mets take Game 1
Tuesday's series opener went New York's way by a 4-2 count in a game that
saw the line shift from the Mets the small MLB betting favorite at the outset before
closing with the Cards drawing light chalk. The victory lifted New York to .500 on
the season (48-48), 12 games back of the Phillies in the NL East, and dropped St. Louis to third in the
NL Central (50-46), 1.5 games behind the Pirates.
Adding to the thrill of victory for the Mets was the return
of stars Jose Reyes and Carlos Beltran following injury stints. The pair combined for five hits and a pair of
runs in Tuesday's win.
McClellan & the Cardinals
It has been nearly two weeks since McClellan (6-6, 4.24)
last experienced game action, and the result was the 5th-straight defeat on his
personal ledger in a 4-1 home loss to the Diamondbacks. The righthander was a -130 favorite in the
contest and it marked the sixth start in a row for McClellan that ended in a
Cardinals defeat after St. Louis
won eight of his first nine.
That early streak for McClellan and the Cards doesn't
include his lone relief appearance of the season on April 22. With rain falling, St. Louis skipper Tony La Russa opted to go
with Miguel Batista to begin that game. Batista only faced one batter before
umpires halted the proceedings with McClellan taking the mound after the delay
and throwing six innings.
A converted reliever, this will be his first career start
vs. the Mets. McClellan came out of the 'pen eight times the previous three
seasons against New York, fashioning a 0.93 ERA in 9.2 innings with Met hitters
batting just a buck ninety-four.
Dickey & the Mets
Dickey (4-8, 3.70) will be out for his first win of the
month despite a decent 3.32 ERA in three July starts. He took the loss at home last Friday to the
Phillies as an even-money underdog, allowing four runs over seven innings in a
7-2 defeat.
The former Tennessee Vol star will also be looking to repeat
his most recent performance against the Redbirds, a start here at Citi Field
just less than a year ago when he came up two outs shy of a complete game
shutout. A -145 MLB money line favorite
in that July 29, 2010 game, Dickey needed 9th-inning help to complete the 4-0 New York triumph.
An underdog in each of his last six assignments, this will
be the first time Dickey has been the favorite or a pick since a June 11
appearance at Pittsburgh.
In his eight games as the favorite or pick this year, the Mets are 1-7 and down
7.75 units.
Wednesday night's forecast for Queens looks fine with
a game-time temp in the low 80s, mostly clear skies and a SSW wind around 10
mph blowing out to center. The two clubs
wrap their series up Wednesday afternoon with a mound battle between Jake
Westbrook and Jonathon Niese.
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text:
Welcome to WebmasterWorld Guest from 126.96.36.199
Forum Moderators: goodroi
Disallow: /widgets.php
You can disallow any resource, in fact what you are disallowing is any URL starting with that item so you could have
Disallow: /widgets
and it would disallow widgets.php, widgets.html, widgets.gif etc.
An interesting comment. What is the reason for this recommendation?
Dijkgraaf is spot on this one - to add some webservers seem NOT to issue redirect so bot won't get a chance to re-check new url (with slash) against robots.txt and thus unintentionally "violate" robots.txt. I had a few of these and ended up removing end slashes from robots.txt's disallow directivies to ensure that my bot won't crawl urls that webmaster clearly wanted not to be crawled even though technically it would have been webmaster's fault.
Not specifying slashes is the wisest way because it catches all possibilities.


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This brick of a case may be bulky for around-town use, but for the backcountry there's nothing better. An onboard battery doubles the life of your phone and is recharged by a solar panel on the back.
The SLXtreme was also the only case in my test with a top-entry hatch, for better waterproofing, and sealed latches over every port. All told, this is one bombproof case that does more than most.
THE KNOCK: Though well recessed, the thin plastic screen cover doesn't have you covered.
Brand: Snow Lizard $130
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text:
I'm too tired to write a blog so I "screenshotted" my instagram sentiments.
I felt it blog-worthy.
questions below are rhetorical and somewhat facetious. I know chickens don't eat grass. I know as much as I want to know about the war on GMO and I am NOT looking for a debate or an argument with the Food Babe groupies. I'm looking for balance, serenity, peace and not feel like my families insides are rotting from cancer because I eat yogurt and cheese and my kids eat sugar.
Archive for the 'quotes' Category
balancePosted: June 13, 2014 in balance, exercise, fitness, food, foodie, happiness, health, health industry, healthy industry, quotes
Tags: cancer, fitness, GMO, health, health fad, healthy craze, monsanto, paleo, whatever
I'm too tired to write a blog so I "screenshotted" my instagram sentiments.
Acceptance is the better way and I do not like Kale. ;)Posted: June 2, 2014 in bathing suits, comedic writing, eating, exercise, fitness, forty, haiku, happiness, health, hip hop, humor, love, moderation, mommy, moms, parenting, peace, quips of wit, quotes, serenity, stay at home mom
Tags: balance, calm, calming, freedom, happiness, jim gaffigan, joy, moderation, peace, peacefulness, serenity
In a world that screams "be better, faster, stronger, thinner, happier, healthier, smarter, bouncier, boingier, etc", we become our own worst critic. I believe in change, but not when it threatens the acceptance of who we are at our core of beautiful personalities, which makes us special, unique, quirky and dynamic.
The most tumultuous battles I fight are with myself are because I'm not measuring up with what "I think" people need me to be doing, saying or being at this very moment. "PEOPLE PLEASING" is a disease and it can literally kill your soul, your creativity, drive addicts to use again, incite aggression and make people mentally breakdown. I know from experience that when I am not being true to myself and my beliefs and I'm "buying in" to what other people are "selling" (metaphorically and literally) and I am not listening to my gut instincts, I end up in situations of regret and resentment.
Yes, we absolutely need to be considerate, kind and strive to help out our fellows. It is the times when we extend ourselves to others in full self abandonment, we end up on an empty gas tank forgetting to "fill~up" the most important person in the relationship equation, ourselves. Self ~ Love does not mean becoming a doormat for others and saying "yes" to every request and demand. People who truly love us want us to say "No" or let our voices be heard. People who thrive on YOUR "people pleasing", are not loving you, they are using and manipulating you to gain something for themselves.
So why is Funny Lady Scrappie-Momma being so serious? I have been doing a lot of soul~searching, trying to find the real cause of my anxiety. I , like many, suffer from anxiety, depression and "projectile~future~vomiting". Trust me , its LIGHT YEARS better than it was in my twenties and even thirties. The truth is, the more peace I feel daily, the more PEACE I need to feel daily, and to shut the mental wars in my mind that occur in my brain. I can create a tornado of distress in the middle of a sunshine filled day if I do not keep the "projectile~future~vomit" "inner voices in check.
I grew up with a lot of chaos. I finally provided a glimpse of my horrendous foster care and schizophrenic Mom stories with my son and his response was "Wow, Mom you are the most interesting person I know!"..Wow, what a revelation, rather than feeling shame or trepidation from my roller coaster childhood, I have amazing knowledge, strength and passion I can share my story in hopes to help others overcome barriers to full inner peace. (book!) For me, when I feel peace, my brain is wired to say "OH SNAP, THIS SHIT ABOUT TO GET REAL, WAIT FOR IT SOMETHING INSANE ABOUT TO POP OFF BRO" (because my inner voice is most definitely a hip hop artist) . The reason my brain is wired like this is because for thirty years, it's exactly how it happened for me!
In my childhood and through adulthood something "popped off" every one, two, to three years without fail. In a mirage of inconsistency, the one driving constant for me was turbulence. Foster care, death, suicide, divorce, alcoholism, anorexia, etc. etc, either circumstantial or of my own , and at the time I thought, innocuous creations. After 18, I definitely would subconsciously create sabotage, drama and mayhem because I thrived on burning the candle with a million ends. I use the terms innocuous and subconscious because I had developed my very own PHD from the"auto-pilot-drama" academy, where I was the student, teacher and graduate, completely oblivious to the sabotage I created for myself and to those around me.
In closing, this blog post started out as a Facebook post on my blog page I lose people after 140 characters and it took on a venue of its own. The only goal I have for myself is to do things that bring me PEACE. I SIMPLY cannot be the Mom trying to outpace other Mom's in whatever societal race we have created to raise Super Children. I cannot buy into the sensationalistic articles ( if you read them all, which I did for two years as a "health~coach") ,after all deductions and conclusions of said reading, I surmise facetiously, Organic Kale is the only food that won't kill us. As Jim Gaffigan so eloquently stated in his recent stand up Obsessed, "Kale tastes like bitter spinach and hair", and after MANY attempts to try and like Kale, I have to agree. I just don't like kale.
This VERY MOMENTPosted: April 18, 2014 in exercise, foodie, happiness, health, humor, laugh, laughing, laughter, love handles, moderation, moms, parenting, peace, poetry, quips of wit, quotes, serenity
Tags: balance, carpe diem, in the moment, laughter, life's moments, meditation, moderation, philosophical, quotes, relaxation, selfhelp, selfless, selflove, therapy
This quote "don't need much splainin'" but I'm a writer so, 'splainin' is my business.
I'm a messy perfectionist betwixt a swiss cheese layering of benevolent narcissism. I struggle with thinking my best isn't ever good enough (for who ?? See below) and as much as I try NOT TO, I absolutely do compare myself to my peers. Im human. I am shocked when people really LIKE me and I sm just as shocked when they don't really LIKE me.
My therapy? Group therapy. Writing. Mediation. Music. Specifically , bootie music (I have blogged about this a few times. :)) Exercise (in moderation). Apologizing when I am wrong. (Which is a lot) . Good food. I am a foodie. Bc I do love layered foods and I hate feel deprived or 'hangry' as the hipster call it. (Sometimes healthy &sometimes because I want a piece of lemon pound cake. ) Moderation. BALANCE. Writing. Writing. Writing & more writing. Laughter. Laughter. Laughter. And more laughter.
I need to read more and analyze less. I need to chill more and analyze less. I need to 'be in the now' more and analyze less. I need to feel more and analyze less. When I was a child, my father constantly and consistently told me to 'slow down'.
If you take away one thing from this short blog, it should be this. You will never regret to moments where you just let youself accept yourself where you are at this VERY MOMENT.
Dream and Grow but don't criticize yourself for all the you are and all that you will be AT THIS VERY MOMENT.
Footnote ** I "stole "don't need much splainin'" from Jason Derulos new song and "benevolent narcissism" from Rob Lowes description of himself. Read Steal Like an Artist by Austin Kleon.


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Outstanding chocolate pointing labs coming in late February, already reserving picks. Sire is HRCH APR Jet SST MH QAA. Dam is Mia Athena del Bosco (pictured here are puppies from her last litter.) Puppies will be ready to go home in April at 8 weeks. Both parents have OFA hips - good, OFA elbows - normal, CERF (eye health) normal. These puppies will be gorgeous , easy to train, and ...
Feb 2 -
Los Angeles :
Redondo Beach - Dogs & puppies
We'll be sending text message alerts for your subscription to


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HSP Lucky Charms Drill
- Uploaded by prepordie on Nov 27, 2012
- Views: 34
Handgun Drills that you can print out, take to the range and work your fundamentals and mindset. These drills allow for a very effective way to get a workout with limited time and ammo. Print out at www.haleystrategic.com keep thinking and be safe!


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In the May issue of InsideCounsel, Kayleigh Roberts and Ashley Trent wrote an excellent article titled "Keeping Up With Evolving E-Discovery." The article referenced an array of "how-to" tactics and best practices for bringing electronic discovery in-house. However, before corporations jump into the "hows" of e-discovery, they should first focus on the "whys"—meaning, why bring electronic discovery in-house in the first place? For many serial litigants or companies in regulated verticals, taking e-discovery in-house is a fait accompli. But for many other enterprises, a bit of soul-searching will be useful before embarking upon the insourcing journey. In the event that the "why" isn't well-defined before evaluating products and vendors, the resulting process may ultimately be a futile effort as diverging interests surface at inopportune times.
Evaluate your pain index


text:
Imagine a comma (,) in the title, like this, "Shine On, You Crazy Diamond." You'll see that the You Crazy Diamond is one construction, the subject of the phrase, as in: "You (Crazy Diamond) Shine On," Or "(You Crazy Diamond) Shine On." Consider the title a command sentence, where the "you" is implied.
"You Crazy Diamond" is a similar construction grammatically to "We Three Kings" or "We the People" or "Bob the Builder". These are all one "subject" or noun-phrase.
Hoping this helps,


text:
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Natalie is a recipe tester for Food52.
Here's a great article from epicurious about cooking turkey in a convection oven. The general consensus is that convection cuts cooking time by about 25% so be sure to check your turkey a lot earlier than you normally would. http://www.epicurious.com...
Cynthia is a trusted source on Bread/Baking.
Alternatively, reduce your oven temp by 25 degrees. And in the end, you're not roasting a turkey for time, but rather to a temperature of 165 degrees.
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The Workforce Development Council of Alabama (WDCA) Region 5 serves the following counties: Calhoun, Cherokee, Clay, Cleburne, Coosa, Etowah, Randolph, Talladega, and Tallapoosa.
The WDCA works closely with the 2-year community college system. The community colleges are a major link to workforce training resources and programs. Click on the name of each community college to go to their website. Central Alabama Community College, Gadsden State Community College, and Southern Union State Community College.


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As a licensed and ordained minister, as well as a graduate from both Christian undergraduate and graduate programs, I can provide you with a solid Scriptural approach to tackling life's problems. I do not however, allow judgement or rejection to invade what we do in our counseling and therapy sessions. You will not be beat over the head with Scripture or hear catch-all recommendations to simply "pray more." We will simply look at what God desires for healthy individuals, families, and couples and how that was revealed in the person of Jesus.
Christian counseling Conway, AR is offered by the same licensed credentialed therapists, but with a focus on spirituality and Biblical guidance. Christian marriage counseling Conway AR through Theravive will put your family and your relationship as a priority over separation and divorce. Our Conway AR Christian counselors will help guide your life in Arkansas through the lens of Christian principles so that you can navigate the right path ahead. Contact a Conway AR Christian marriage therapist or Conway, AR Christian counselor to begin your new journey of discovery and healing.
Welcome to our network of Conway AR Christian counseling for marriages, families, relationships, and individuals. If you are seeking a Conway Christian marriage counselor or Christian therapist, our professionals are able to help you. Emphasising Christian and Biblical truths, therapy with a licensed Christian counselor in Conway, AR can help bring you through the issues you face, and restore your life to the right path.
Our purpose is to help people everywhere find great counselors and psychologists. Everyone can have a new start in life.
Theravive does not provide medical advice, diagnosis, or treatment.
Read here for more info.


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I used a lot of skype plugins, but this plugin is the best one. Easy to install and worked perfect. Thanks very much!!!
Neat settings, lot of options and Aurimas is very helpful with the support, he even changed one of the features as per request.
I really like the versatility of this plugin: shortcodes, floating icon, widgets, single or integrated accounts - all there.
Thanks Aurimas!
Using this plugin to offer user support at our school board. I read great reviews from others before i went for v2, they were right! Easy to install, easy to setup, fully customizable, not to mention extremely fast and friendly customer support. Definitely worth the donation. Thanks!
It is useful for small business
Works perfectly on my site.
It's great you can put more than one account and it SELECTS the first online, for the PRO version, of course.
This is a great little plugin for adding Skype functionality to your web site. Whether you are a small-time blogger or a big business, you can give your readers/customers the ability to chat, call, or video call you and/or your associates directly from your web site. Great for offering a bit of socializing on your blog or serious support on your business site. On top of it all, the author offers great support and gets right back to you if you have any questions. A+
It Works Really well and its simplistic.. And another pluss the author is very willing to help with support... Good one this
I highly recommend PRO version.
This plugin works really good!
Transparent buttons, auto update.
Must have, if you want to link your Skype account!
Works great on my site and I particularly pleased with the ability to have multiple skype accounts active on the site. We use skype extensively in my company in every department. This will help out a lot.
The programmer is responsive and assures me that he is working diligently on moving the customization into the UI, for all of the non-programmers to use.
You must log in to submit a review. You can also log in or register using the form near the top of this page.


text:
Retro Bliss by SpashaiWatch
©2013-2016 Spashai
Commission for =jellyfiishes
^o^ Hope you like it! It was nice to do a retro doll again, I haven't done one for ages :'3
--- -- -
Art © =Spashai • Characters © =jellyfiishes • Style © =Spashai - - 9 nov 2013 - - buying a commission does NOT give you the right to violate the copyrights
ahh this looks amazing girl! ;v; your retro dolls are baws<33
This is very cool, I wonder how you do that...I mean...being so clean and neat at pixeling?? 8D <3 Looks amazing! :3 ♥
Wow this looks amazing! I love those colors, it gives a shimmery and bright feeling to it. Bliss looks awesome in your style haha! I love how you drew the cape as well /w\ thanks so much! i believe i paid right? ouo
:'D I'm so glad you like it! Bliss is really suited to retro-fying~
You're welcome, and yep, you paid! ^o^
So cute! I love this!
Are commissions open?


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With some amazing live performances, a touch of controversy and DJs to boot, the 2003 DMAs were a great night all around for attendees and viewers alike. A special congratulations to multi awards winners Phil K, Vicious Vinyl, 1200 Techniques and Infusion.
And the winners are:
Outstanding Contribution to Dance: : Phil K
Best Album : 1200 Techniques_'Choose One'_Sony
Best Single : Infusion_'Dead Souls'_Marine Parade
Best Compilation : A Night Out With Vicious_Grooves_Vicious Vinyl
Best Producer : Infusion (Jamie Stevens, Manuel Sharrad and Frank Xavier)
Best Independent Label :Vicious Vinyl
Best Remix : Poxymusic Vs Kid Kenobi remix of Green Velvet 'La La Land'
Best DJ (National) : Phil K
Best Mix CD : Phil K_'Balance 004'_EQ Recordings
Best Video Clip : 'One Of My Kind' – Rogue Traders – Rising Sun Pictures [Animation] and Vixen [Dir. Sam Bennet]
Best Hip Hop Act :1200 Techniques
Best Turntablist : Dexter
Best Urban Act : Jeremy Gregory
Best Live Act : Resin Dogs
Best Debut Artist : Downsyde
Peoples Choice>
Best club night
VIC - Bass Station @ The Palace
NSW - Sublime @ Home
SA - Clubland @ Heaven
QLD - Saturdays @ Family
WA - Saturdays @ Rise
Best DJ
NSW - Kid Kenobi
VIC - John Course
SA - DJ Brendon
WA - Simon Barwood
QLD - Baby Gee
Best Event - Two Tribes
Best International DJ - Adam Freeland


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- Sports & Recreation
- Basketball
- Miami Heat
- Boston Celtics
- LeBron James
Celtics' Green sinks winner against Heat at buzzer
|Entry Fee
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|NBA $10K Tournament [$1K to 1st]
|Today 1:00 PM Enter
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Conor McGregor Continues To Talk Trash About Everyone In The UFC
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French to the fore as Federer misses Rotterdam tennis tournament
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The Big 12 has one true champion and now one voice on expansion
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Axl Rotten, Former WWE Wrestler, Dies at 44
Axl Rotten, a former WWE and ECW superstar, has died at the age of 44. Rotten, whose real name was Brian Knighton, was found dead in Baltimore on Thursday night. Rotten started out on the independent wrestling circuit in the late 1980s, where he met Ian Rotten (real name: John Williams), the man…The Wrap


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text: "Thank you for supporting Interactive Drama." David Cage may not repeat his digitised Fahrenheit appearance, but his voice rings clear in the first Trophy Heavy Rain awards. Odd it should arrive at the outset, where our 'support' amounts to one glass of orange juice glugged and two children entertained. Perhaps Cage means to reassure us. After months of struggling to describe and defend individual moments, Quantic Dream has found a confidence in the whole. But where great movies are unified in the editing suite, Heavy Rain's strength lies in those earlier inconsistencies. 7/10


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Publications (19)45.29 Total impact
Article: Screening for Congenital Hypothyroidism: The Significance of Threshold Limit in False-Negative Results[Show abstract] [Hide abstract]
ABSTRACT: In our neonatal program, a number of infants with congenital hypothyroidism (CH) had escaped diagnosis, when a spot RIA-TSH value of 20 mU/liter whole blood was used as a cutoff point. The objective of the study was to find out prospectively the additional number of newborns with CH if the TSH cutoff point is lowered to 10 mU/liter. The study included 311,390 screened newborns. The children with CH were followed up for a period of 3 yr. Twenty-eight percent of infants diagnosed with CH had neonatal TSH values between 10 and 20 mU/liter (56 of 200). Forty of 47 infants, who were reevaluated later on (85.1%), suffered permanent CH. A thyroid scintiscan and/or echogram revealed that eight of 40 children (20.0%) had a structural defect, and the remaining (32 of 40) had a functional defect of the thyroid gland without anatomical abnormality; 14 of 32 cases were familial. Eighteen of the 47 reevaluated infants were prematurely born (38.3%) and 15 of these 18 had permanent CH (83.3%). The lowering of TSH cutoff point from 20 to 10 mU/liter resulted in a 10-fold increase of recall rate. A significant number of cases with permanent CH are missed when a TSH threshold of 20 mU/liter is applied. Almost 40% of the missed CH cases were premature. A mild increase of TSH at screening is not a predictor of transient CH. The increase in recall rate constitutes a serious drawback and should be balanced against the possible consequences of thyroid dysfunction at this important developmental stage.
Article: Easy, Rapid, and Cost-Effective Methods for Identifying Carriers of Recurrent GJB2 Mutations Causing Nonsyndromic Hearing Impairment in the Greek Population[Show abstract] [Hide abstract]
ABSTRACT: A variety of techniques have been developed for screening the GJB2 gene for known and unknown mutations, especially the most common mutation in the Caucasian population, the c.35delG. Other mutations that have been so far characterized in the GJB2 gene seem to have different geographical distributions, and therefore there is an interest in identifying recurrent mutations specific for each population and developing easy and rapid screening techniques. Here we present easy screening protocols for already identified recurrent mutations in the Greek population. Developing easy, rapid, and cost-effective screening methods will facilitate the detection of GJB2 recurrent mutation carriers, at large, in the Greek population.
Article: Hypothesizing an Ancient Greek Origin of the GJB2 35delG Mutation: Can Science Meet History?[Show abstract] [Hide abstract]
ABSTRACT: One specific mutation of the GJB2 gene that encodes the connexin 26 protein, the 35delG mutation, has become a major interest among scientists who focus on the genetics of nonsyndromic hearing loss. The mutation accounts for the majority of GJB2 mutations detected in Caucasian populations and represents one of the most frequent disease mutations identified so far. The debate was so far between the arguments whether or not the 35delG mutation constitutes a mutational hot-spot or a founder effect; however, it was recently clarified that the latter seems the most likely. In an attempt to explore the origin and propagation of the 35delG mutation, several groups have reported the prevalence of the mutation and the carrier rates in different populations worldwide. It is now certain that the theory of a common founder prevails and that the highest carrier frequencies of the 35delG mutation are observed in southern European populations, giving rise to a discussion regarding the origin of the 35delG mutation. In this study, we discuss data previously published by our and other groups and also compare the haplotype distribution of the mutation in southern Europe, trying to understand the pathways of science and history and the conflict between them.
Article: Primary open angle glaucoma due to T377M MYOC: Population mapping of a Greek founder mutation in Northwestern Greece[Show abstract] [Hide abstract]
ABSTRACT: Mutations in the MYOC gene have been shown to explain 5% of unrelated primary open angle glaucoma (POAG) in different populations. In particular, the T377M MYOC mutation has arisen at least three separate times in history, in Great Britain, India, and Greece. The purpose of this study is to investigate the distribution of the mutation among different population groups in the northwestern region of Greece. We explored the distribution of the "Greek" T377M founder mutation in the Epirus region in Northwestern Greece, which could be its origin. Genotyping was performed in POAG cases and controls by PCR amplification of the MYOC gene, followed by digestion with restriction enzyme. Statistical analyses were performed by an exact test, the Kaplan-Meier method and the t-test. In the isolated Chrysovitsa village in the Pindus Mountains, a large POAG family demonstrated the T377M mutation in 20 of 66 family members while no controls from the Epirus region (n = 124) carried this mutation (P < 0.001). Among other POAG cases from Epirus, 2 out of 14 familial cases and 1 out of 80 sporadic cases showed the mutation (P = 0.057). The probability of POAG diagnosis with advancing age among mutation carriers was 23% at age 40, and reached 100% at age 75. POAG patients with the T377M mutation were diagnosed at a mean age of 51 years (SD +/- 13.9), which is younger than the sporadic or familial POAG cases: 63.1 (SD +/- 11) and 66.8 (SD +/- 9.8) years, respectively. The T377M mutation was found in high proportion in members of the Chrysovitsa family (30.3%), in lower proportion in familial POAG cases (14.2%) and seems rare in sporadic POAG cases (1.2%), while no controls (0%) from the Epirus region carried the mutation. Historical and geographical data may explain the distribution of this mutation within Greece and worldwide.
Article: Are GJB2 mutations an aggravating factor in the phenotypic expression of mitochondrial non-syndromic deafness?[Show abstract] [Hide abstract]
ABSTRACT: Hearing impairment is a frequent condition, and genes have an important role in its etiology. The majority of hearing loss occurs in non-syndromic form, with deafness being the only clinically recognizable feature. More than 60 nuclear genes or loci have been shown to be involved in non-syndromic hearing loss, but mutations in mitochondrial DNA also cause hearing impairment. Mitochondrial DNA mutations usually lead to progressive hearing loss with an age of onset varying from childhood to early adulthood. It is interesting to note that there is a great variability among phenotypes between individuals harboring the same mitochondrial mutation, even within the same family, and the phenotype may range from profound deafness to completely normal hearing. In the past years, the debate on mitochondrial mutations has been about the penetrance, the tissue specificity and the mechanisms of modifier genes that can modulate the severity of the phenotypic expression of the deafness-associated mitochondrial DNA mutations. Here we summarize evidence regarding modifying genes, and we discuss the effect of the coexistence of mitochondrial and GJB2 mutations in families reported to date.
Article: The A1555G mitochondrial DNA mutation in Greek patients with non-syndromic, sensorineural hearing loss[Show abstract] [Hide abstract]
ABSTRACT: Mitochondrial DNA mutations are undoubtedly a factor that contributes to sensorineural, non-syndromic deafness. One specific mutation, the A1555G, is associated with both aminoglycoside-induced and non-syndromic hearing impairment. The mutation is considered to be the most common of all mitochondrial DNA deafness-causing mutations but its frequency varies between different populations. Here we report on the first large screening of the A1555G mitochondrial DNA mutation in the Greek population. The aim of this study was to determine the frequency of the A1555G mutation in Greek sensorineural, non-syndromic deafness patients, with childhood onset. We screened 478 unrelated Greek patients with hearing loss of any degree and found two individuals harboring the A1555G mutation (0.42%). Both cases had been subjected to aminoglycosides. They were prelingual, familial and homoplasmic for the A1555G mutation. One of the cases was also found heterozygous for the frequent GJB2 35delG mutation, while the other case was negative. The A1555G mutation seems to be less common than in other European populations.
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ABSTRACT: The aim of this study was to investigate whether there is a correlation between copper (Cu) and zinc (Zn) levels in children and their parents, considering their nutritional habits. Cu and Zn concentrations were measured by flame atomic absorption spectrophotometry in the serum of 66 healthy children, aged 3-14 years, and their parents, residing in a region of Greece (Thrace). Cu levels were higher in mothers than those in fathers, but they were lower in both parents than those in children. They also tended to decrease with age in both parents and children, whereas Zn levels significantly increased with age in children. There was a positive correlation between children's and mothers' Zn levels, as well as children's and both parents' Cu levels. Children used to eat meat, fish, vegetables, and legumes as frequently as their parents, but they were consuming more eggs, milk, and fruits than the latest. Regarding parents' diet, higher Zn levels were depended on the consumption of meat and milk, whereas higher Cu levels were depended on the consumption of milk. Consequently, children's Cu and Zn levels are related to their parents' levels, which can be influenced by their nutritional habits.
Article: Investigating the Impact of the Down Syndrome Related Common MTHFR 677C>T Polymorphism in the Danish Population[Show abstract] [Hide abstract]
ABSTRACT: Chromosomal aneuploidy consists the leading cause of fetal death in our species. Around 50% of spontaneous abortions until 15 weeks of gestational age are chromosomally aneuploid, with trisomies accounting for 50% of the abnormal abortions. Trisomy 21 is the most common chromosome abnormality in liveborns and is usually the result of nondisjunction of chromosome 21 in meiosis in either oogenesis or spermatogenesis. To investigate the relationship between folate metabolism and Down syndrome (DS) in a Danish population, we analyzed the common 677C>T genetic polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene. Our cohort consisted of 181 mothers of children with DS versus 1,084 healthy controls. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were used to examine the MTHFR 677C>T polymorphism. No significant association between the polymorphism and the risk for DS was found. We conclude that the common MTHFR 677C>T polymorphism is not likely to be a maternal risk factor for DS in our cohort and that the difference to previous studies can probably be explained by small sample size or geographic variation in gene polymorphisms involving gene-nutritional or gene-gene or gene-nutritional-environmental factors.
Article: Strong Linkage Disequilibrium for the Frequent GJB2 35delG Mutation in the Greek Population[Show abstract] [Hide abstract]
ABSTRACT: Approximately one in 1,000 children is affected by severe or profound hearing loss at birth or during early childhood (prelingual deafness). Up to 40% of congenital, autosomal recessive, severe to profound hearing impairment cases result from mutations in a single gene, GJB2, that encodes the connexin 26 protein. One specific mutation in this gene, 35delG, accounts for the majority of GJB2 mutations detected in Caucasian populations. Some previous studies have assumed that the high frequency of the 35delG mutation reflects the presence of a mutational hot spot, while other studies support the theory of a common founder. Greece is among the countries with the highest carrier frequency of the 35delG mutation (3.5%), and a recent study raised the hypothesis of the origin of this mutation in ancient Greece. We genotyped 60 Greek deafness patients homozygous for the 35delG mutation for six single nucleotide polymorphisms (SNPs) and two microsatellite markers inside or flanking the GJB2 gene. The allele distribution in the patients was compared to 60 Greek normal hearing controls. A strong linkage disequilibrium was found between the 35delG mutation and markers inside or flanking the GJB2 gene. Furthermore, we found a common haplotype with a previous study, suggesting a common founder for the 35delG mutation.
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ABSTRACT: Valproic acid (VPA) treatment and paraoxonase1/arylesterase (PON1/Aryl) activities are related to the production of free radicals. Our aim was to study the PON1/Aryl activities in children on VPA therapy. Thirty-two children with seizures and 30 healthy child volunteers took part. Ill children underwent the common laboratory tests, as well as total antioxidant status (TAS), total oxidant status (TOS), lipid profile, liver enzymes and PON1/Aryl activities pre- and post-60 days on VPA therapy (30 mg/kg/24 h), whereas the healthy children were tested just once. None of the studied biochemical parameters differed between volunteers and children with seizures pretreatment. Liver enzymes, lipids and TOS levels (124+/-30 versus 580+/-40 micromol/L; p<0.001) were significantly elevated, whereas the activities of PON1/Aryl (146+/-43 versus 118+/-40 U/mL/min 120+/-42 versus 98+/-38 KU/mL/min; p<0.01) and TAS levels (436+/-42 versus 288+/-39 micromol/L; p<0.001) were decreased in children after treatment. Additionally, strong negative correlations were found between PON1/Aryl activities, liver enzymes, TOS (r = -0.69) and VPA levels (r = -0.57), whereas PON1/Aryl activities correlated positively with TAS, HDL and Apo A-I in all groups. Serum PON1/Aryl activities were decreased after 60 days on VPA treatment, probably due to liver dysfunction and free radicals production by VPA, without excluding the possibility of a direct action of the drug on the enzymes.
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ABSTRACT: Mutations of GJB2, the gene encoding connexin 26, have been associated with prelingual, sensorineural hearing loss of mild to profound severity. One specific mutation, the 35delG, has accounted for the majority of mutations detected in the GJB2 gene in Caucasian populations. Recent studies have described progression of hearing loss in a proportion of cases with GJB2 deafness. We report an unusual family with four 35delG homozygous members, in which the parents were deaf-mute whilst both children had a postlingual progressive hearing loss. Furthermore, the son suffered from sudden hearing loss.
Article: Cohen syndrome resulting from a novel large intragenic COH1 deletion segregating in an isolated Greek island population[Show abstract] [Hide abstract]
ABSTRACT: Cohen syndrome, caused by mutations in the COH1 gene, is an autosomal recessive disorder consisting of mental retardation, microcephaly, growth delay, severe myopia, progressive chorioretinal dystrophy, facial anomalies, slender limbs with narrow hands and feet, tapered fingers, short stature, kyphosis and/or scoliosis, pectus carinatum, joint hypermobility, pes calcaneovalgus, and, variably, truncal obesity. Here, we describe the clinical and molecular findings in 14 patients from an isolated Greek island population. The clinical phenotype was fairly homogeneous, although microcephaly was not constant, and some patients had severe visual disability. All patients were homozygous for a novel intragenic COH1 deletion spanning exon 6 to exon 16, suggesting a founder effect. The discovery of this mutation has made carrier detection and prenatal diagnosis possible in this population.
Article: Pathologic, radiographic and molecular findings in three fetuses diagnosed with HEM/Greenberg skeletal dysplasia[Show abstract] [Hide abstract]
ABSTRACT: Greenberg skeletal dysplasia is a very rare, autosomal recessive, in utero, lethal chondrodystrophy for which only eight index cases of diverse ethnic origin have been reported so far. The defect is associated with a defect in cholesterol biosynthesis and due to mutations in the gene encoding the lamin B receptor (LBR). A familial case of three fetuses of a consanguineous Greek couple is presented including prenatal, physical, radiographic, histopathologic, and molecular genetic findings. The tentative diagnosis of Greenberg skeletal dysplasia based on pathological findings was confirmed by the identification of a homozygous, N547D amino acid substitution in the LBR gene in the third affected fetus. The present case represents the ninth described case of Greenberg dysplasia and the second case of Greek origin. The characteristic 'moth-eaten' radiographic appearance is already seen at 13 weeks' gestational age.
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ABSTRACT: Vitamin D status in humans depends on the amount of sun exposure and vitamin D intake. Recent reports suggest that hypovitaminosis D (as defined by serum 25-hydroxyvitamin D [25(OH)D] <10 ng/mL) is reemerging in developed countries and in the Middle East, pointing out the significance of dietary and cultural practices. In the line of prevention, we determined vitamin D status in 393 healthy preschool children randomly selected from 7 day care centers in the Municipality of Athens in October. The data for the analysis were collected from a questionnaire regarding their actual dietary practices, voluntary sun exposure, and lifestyle conditions; clinical investigation for the determination of the skin phototype; and blood sampling for the determination of serum 25(OH)D, parathyroid hormone, and osteocalcin levels. Of the 393 children, 49 were immigrants. According to our results, 6.6% of our population had serum 25(OH)D less than 10 ng/mL. Multilinear analysis showed that the amount of sun exposure and vitamin D intake were the direct determinants of vitamin D status. Immigrant children presented lower serum 25(OH)D levels associated with lower vitamin D intake and lower socioeconomic class when compared with the Greek children. No relationship was found between 25(OH)D concentration and skin phototype, whereas 93.3% of children used topical sunscreen. We suggest that abundant sunlight exposure in Athens is not sufficient to prevent hypovitaminosis D in preschool children. The extensive use of topical sunscreens and environmental factors such as air pollution would account for inadequate sunlight exposure and the need for dietary intake of vitamin D.
Article: Erythrocyte membrane Na+,K+-ATPase and Mg 2+-ATPaSe activities in subjects with methylenetetrahydrofolate reductase (MTHFR) 677 C→T genotype and moderate hyperhomocysteinaemia. The role of L-phenylalanine and L-alanine[Show abstract] [Hide abstract]
ABSTRACT: Increased homocysteine (Hcy) blood levels are correlated with vascular and neurological problems. The aim of our study was to investigate erythrocyte membrane Na(+),K(+)-ATPase and Mg(2+)-ATPase activities in patients with methylenetetrahydrofolate reductase (MTHFR) 677 C-->T genotype. Blood was obtained from 25 patients before and after folic acid supplementation and from controls (n=30) once. Plasma folate, vitamin B(12) and total antioxidant status (TAS) were measured using commercial kits, Hcy was determined by HPLC and membrane enzyme activities were measured spectrophotometrically. Mg(2+)-ATPase remained unaltered. Membrane Na(+),K(+)-ATPase activity was remarkably increased in patients (0.77+/-0.06 micromol Pi/h x mg protein) and decreased to normal levels (0.52+/-0.05 micromol Pi/h x mg protein; p<0.001) after therapy. TAS did not differ significantly before and after treatment. Hcy levels were significantly higher before therapy (25.4+/-2.8 micromol/L) than levels after therapy (12.1+/-2.0 micromol/L; p<0.001) and in controls (10.5+/-2.5 micromol/L, p<0.001). In vitro, L-phenylalanine (Phe) reversed to normal the stimulated enzyme from patients before therapy. In addition, Phe incubation of the Hcy activated membrane Na(+),K(+)-ATPase from controls resulted in restoration of its activity, whereas L-alanine (Ala) incubation protected the enzyme from Hcy activation. The increased membrane Na(+),K(+)-ATPase activity may be due to high -SH group Hcy levels. In vitro, Phe reversed the increase in enzyme activity induced by Hcy in controls, as well as the stimulated membrane enzyme in untreated patients. Ala protected the enzyme from Hcy action.
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ABSTRACT: Hypocalcemic vitamin D-resistant rickets (HVDRR) is a rare monogenic autosomal recessive disorder associated with mutations in the gene of the vitamin D receptor (VDR), the mediator of 1,25(OH)2D3 action. Although many investigations have discussed the clinical manifestations and molecular etiology of this disease, only a few have investigated the biochemical and hormonal status of heterozygous HVDRR. The aim of the current work was to investigate the profile of selected biochemical and hormonal parameters related to the vitamin D endocrine system in a large number of HVDRR heterozygotes. 67 relatives of 2 HVDRR patients, all members of an extended Greek kindred of five generations with a common ancestor, were included in the study. Direct sequencing was used to identify VDR gene mutations. Serum Ca, P, 25(OH)D, iPTH, and 1,25(OH)2D levels were determined in all members of the kindred. DNA analysis of the participants led to the design of two study groups: the HVDRR carriers (24) and the control subjects (43). Our results showed elevated circulating serum levels of 1,25(OH)2D3 and lower levels of PTH than their age- and sex-matched controls. No hypocalcemia or hypophosphatemia were detected in HVDRR carriers. Our findings suggest that HVDRR carriers may have compensatory elevated serum levels of 1,25(OH)2D3 through which they restrain PTH secretion. The study of HVDRR carriers could be a useful tool for the investigation of the vitamin D endocrine system.
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ABSTRACT: Melatonin is the main hormone secreted by the pineal gland in the human brain. It has a strong impact on the sleep-wake cycle and is considered a general modulator of the human circadian rhythm. Apart from these well-established properties, melatonin possesses immunomodulatory, antioxidative and antiinflammatory properties. The potential ability of this hormone to act synergistically with several cytokines by enhancing their antitumoral activity and dramatically decreasing their adverse effects has placed melatonin among the new and promising agents in cancer immunotherapy. The use of the neurohormone alone or in combination with cytokines and traditional chemotherapeutic drugs is currently under vigorous investigation. Experimental and clinical trials have already depicted some of the immunomodulatory and antitumor effects of melatonin, delineating the need for further research in this field.
Article: Erythrocyte membrane acetylcholinesterase activity in subjects with MTHFR 677C -> T genotype[Show abstract] [Hide abstract]
ABSTRACT: Increased homocysteine (Hcy) blood levels are correlated with vascular and neurological problems. The aim of the present study was to investigate erythrocyte membrane acetylcholinesterase (AChE) activity in subjects with the MTHFR C677T genotype in relation to Hcy. Blood was obtained from 22 individuals with the MTHFR C677T genotype before and after folic acid supplementation and once from controls (n = 30). Plasma folate, vitamin B(12) and total antioxidant status (TAS) were measured with commercial kits, Hcy by a HPLC method and membrane enzyme activity spectrophotometrically. In MTHFR C677T carriers, AChE activity was significantly higher (4.20 +/- 0.12 x mg protein) and decreased to normal levels (3.14 +/- 0.10 x mg protein; p < 0.001) after therapy. TAS differed slightly before and after treatment. Hcy levels were significantly higher before (22.4 +/- 2.8 microM) compared to after (12.1 +/- 2.0 microM; p < 0.001) therapy and compared to controls (10.5 +/- 2.5 micromol/L; p < 0.001). In an in vitro study, incubation of Hcy-activated membrane AChE from controls with phenylalanine resulted in restoration of activity, but failed to reverse the stimulated enzyme from hyperhomocysteinaemic MTHFR C677T subjects before therapy. Alanine incubation protected the enzyme from Hcy activation in controls. Increased membrane AChE activity may be due to high Hcy levels. In vitro, phenylalanine reversed the Hcy activation of the membrane enzyme from controls and alanine protected it from Hcy action.
Article: The effect of aspartame metabolites on human erythrocyte membrane acetylcholinesterase activity[Show abstract] [Hide abstract]
ABSTRACT: Studies have implicated aspartame (ASP) with neurological problems. The aim of this study was to evaluate acetylcholinesterase (AChE) activity in human erythrocyte membranes after incubation with the sum of ASP metabolites, phenylalanine (Phe), methanol (met) and aspartic acid (aspt), or with each one separately. Erythrocyte membranes were obtained from 12 healthy individuals and were incubated with ASP hydrolysis products for 1 h at 37 degrees C. AChE was measured spectrophotometrically. Incubation of membranes with ASP metabolites corresponding with 34 mg/kg, 150 mg/kg or 200 mg/kg of ASP consumption resulted in an enzyme activity reduction by -33%, -41%, and -57%, respectively. Met concentrations 0.14 mM, 0.60 mM, and 0.80 mM decreased the enzyme activity by -20%, -32% or -40%, respectively. Aspt concentrations 2.80 mM, 7.60 mM or 10.0 mM inhibited membrane AChE activity by -20%, -35%, and -47%, respectively. Phe concentrations 0.14 mM, 0.35 mM or 0.50mM reduced the enzyme activity by -11%, -33%, and -35%, respectively. Aspt or Phe concentrations 0.82 mM or 0.07 mM, respectively, did not alter the membrane AChE activity. It is concluded that low concentrations of ASP metabolites had no effect on the membrane enzyme activity, whereas high or toxic concentrations partially or remarkably decreased the membrane AChE activity, respectively. Additionally, neurological symptoms, including learning and memory processes, may be related to the high or toxic concentrations of the sweetener metabolites.
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Institute of Child Health - GreeceAthínai, Attica, Greece
Harokopion University of AthensAthínai, Attica, Greece
Aghia Sophia Children's HospitalAthínai, Attica, Greece


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Publications (15)68.07 Total impact
Article: Cryptosporidiosis in Children With Acute Lymphoblastic Leukemia on Maintenance Chemotherapy[Show abstract] [Hide abstract]
ABSTRACT: Cryptosporidium is recognized as a cause of diarrhea associated with a high mortality in immunocompromised patients. We report on 2 pediatric cases of cryptosporidiosis during maintenance chemotherapy of acute lymphoblastic leukemia. The patients presented severe diarrheas, 1 of them was complicated by a cholangitis. Withdrawal of immunosuppressive treatments and adjunction of an adequate antiparasitic treatment cured the Cryptosporidium infection in both cases.
Article: 260 Myelodysplasia and leukemia of Fanconi anemia are associated with a specific pattern of genomic abnormalities that includes RUNX1/AML1 lesions[Show abstract] [Hide abstract]
ABSTRACT: Fanconi anemia (FA) is a genetic condition associated with bone marrow (BM) failure, myelodysplasia (MDS), and acute myeloid leukemia (AML). We studied 57 FA patients with hypoplastic or aplastic anemia (n = 20), MDS (n = 18), AML (n = 11), or no BM abnormality (n = 8). BM samples were analyzed by karyotype, high-density DNA arrays with respect to paired fibroblasts, and by selected oncogene sequencing. A specific pattern of chromosomal abnormalities was found in MDS/AML, which included 1q+ (44.8%), 3q+ (41.4%), -7/7q (17.2%), and 11q- (13.8%). Moreover, cryptic RUNX1/AML1 lesions (translocations, deletions, or mutations) were observed for the first time in FA (20.7%). Rare mutations of NRAS, FLT3-ITD, MLL-PTD, ERG amplification, and ZFP36L2-PRDM16 translocation, but no TP53, TET2, CBL, NPM1, and CEBPα mutations were found. Frequent homozygosity regions were related not to somatic copy-neutral loss of heterozygosity but to consanguinity, suggesting that homologous recombination is not a common progression mechanism in FA. Importantly, the RUNX1 and other chromosomal/genomic lesions were found at the MDS/AML stages, except for 1q+, which was found at all stages. These data have implications for staging and therapeutic managing in FA patients, and also to analyze the mechanisms of clonal evolution and oncogenesis in a background of genomic instability and BM failure.
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ABSTRACT: Patients with near-tetraploid (karyotype: 81 - 103 chromosomes) acute lymphoblastic leukemia (NT-ALL) constitute about 1% of childhood ALL and data reported on them are limited and controversial. The aim of the study was to enlarge the knowledge on these rarely occurring ALL. The members of the European Group for Immunophenotyping of Leukemias (EGIL) searched retrospectively their databases for NT-ALL patients. We collected data of 36 European children from seven European countries with NT-ALL diagnosed since 1992. All patients reached complete remission (CR) after induction chemotherapy. Their blasts were negative for peroxidase and BCR-ABL1. Ten children were diagnosed as T-cell ALL (T-ALL) EGIL categories (T-I n=2, T-II n=2, T-III n=3, T-IV n=3) and four displayed various structural chromosomal abnormalities. Eight of 10 T-ALL remained in 1st CR; one died in CR from sepsis and one is alive in 2nd CR. Median survival was 88 (7-213) months. B-cell precursor (BCP) ALL was diagnosed in 26 children. Thirteen were positive for ETV6-RUNX1 and are alive in 1st CR for 32-147 months. Ten children were ETV6-RUNX1 negative and remained in 1st CR for 16-163 months. One girl with hypodiploid and NT metaphases and ETV6-RUNX1-negative BCP-ALL and one of two boys with NT-BCP-ALL not examined for ETV6-RUNX1 died of infection after stem cell transplantation in 2nd/3rd CR. Secondary myelodysplastic syndrome developed in two patients with NT-BCP-ALL. Our data demonstrate immunophenotypic, cytogenetic, and molecular heterogeneity of NT-ALL and favorable prognosis of most NT-ALL across different immunophenotypic and/or genetic ALL subtypes.
Article: Wide diversity of PAX5 alterations in B-ALL: A Groupe Francophone de Cytogénétique Hématologique study[Show abstract] [Hide abstract]
ABSTRACT: PAX5 is the main target of somatic mutations in acute B lymphoblastic leukemia (B-ALL). We analyzed 153 adult and child B-ALL harboring karyotypic abnormalities at chromosome 9p, to determine the frequency and the nature of PAX5 alterations. We found PAX5 internal rearrangements in 21% of the cases. To isolate fusion partners, we used classic and innovative techniques (rolling circle amplification-rapid amplification of cDNA ends) and single nucleotide polymorphism-comparative genomic hybridization arrays. Recurrent and novel fusion partners were identified, including NCoR1, DACH2, GOLGA6, and TAOK1 genes showing the high variability of the partners. We noted that half the fusion genes can give rise to truncated PAX5 proteins. Furthermore, malignant cells carrying PAX5 fusion genes displayed a simple karyotype. These data strongly suggest that PAX5 fusion genes are early players in leukemogenesis. In addition, PAX5 deletion was observed in 60% of B-ALL with 9p alterations. Contrary to cases with PAX5 fusions, deletions were associated with complex karyotypes and common recurrent translocations. This supports the hypothesis of the secondary nature of the deletion. Our data shed more light on the high variability of PAX5 alterations in B-ALL. Therefore, it is probable that gene fusions occur early, whereas deletions should be regarded as a late/secondary event.
Article: Successful salvage chemotherapy for isolated central nervous system (CNS) relapse in burkitt lymphoma: Monocentric experience of 3 pediatric patients[Show abstract] [Hide abstract]
ABSTRACT: Short-term intensive chemotherapy regimens have substantially improved the prognosis of pediatric patients with Burkitt lymphoma (BL), which now has an excellent overall outcome. However, central nervous system (CNS) involvement at diagnosis remains a poor prognostic factor, and progressive or relapsed disease in the CNS is associated with even worse outcomes. We report 3 boys aged 4, 7, and 12 years treated under the French Société Française d'Oncologie Pédiatrique LMB 89/96 protocols who presented, respectively, with CNS-/bone marrow+ stage-IV BL; CNS+ stage-IV BL; and stage-I BL. Each experienced an isolated CNS relapse, which was treated with CNS-directed salvage chemotherapy. All 3 are alive after 11 years of median follow-up, indicating that this chemotherapy regimen can be curative in pediatric BL with isolated CNS relapse.
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ABSTRACT: To demonstrate that primary human herpesvirus 6 (HHV-6) infection in childhood can cause hematopoietic dysplasia that mimics a myelodysplastic syndrome (MDS) in severe cases. Seven immunocompetent children, who presented at admission with concomitant cytopenias in blood and morphologic features of dysplasia in bone marrow, were evaluated. Diagnosis of acute HHV-6 infection was secondary made by detection of HHV-6 DNA in plasma, bone marrow, or cerebrospinal fluid and measurement of plasma antibody titers. Peripheral blood and bone marrow aspirate smears were examined at diagnosis and during follow-up. Morphologic recognition of myelodysplasia was made according to the recommendations of the Third MIC Cooperative Group. Anemia was the most frequent cytopenia (five of seven cases). Bi- or tri-lineage dysplasia was observed in the marrow samples. Granulocytic and erythroid cells were always affected with dysgranulopoiesis and dyserythropoiesis scores equal to or higher than 3. Myelodysplasia was not due to a clonal disorder and disappeared gradually within 1 or 2 months. Our results indicate that severe HHV-6 infection may induce reversible myelodysplastic changes. These findings contribute to elucidate the pathogenicity of HHV-6 and furthermore suggest that HHV-6 infection must also be considered as a cause of dysplasia in the differential diagnosis of MDS.
Article: Abnormalities of the long arm of chromosome 21 in 107 patients with hematopoietic disorders: a collaborative retrospective study of the Groupe Français de Cytogénétique Hématologique[Show abstract] [Hide abstract]
ABSTRACT: Chromosome 21 is frequently rearranged in hematopoietic malignancies. In order to detect new chromosomal aberrations, the Groupe Français de Cytogénétique Hématologique collected a series of 107 patients with various hematologic disorders and acquired structural abnormalities of the long arm of chromosome 21. The abnormalities were subclassified into 10 groups, according to the location of the 21q breakpoint and the type of abnormality. Band 21q22 was implicated in 72 patients (excluding duplications, triplications, and amplifications). The involvement of the RUNX1 gene was confirmed in 10 novel translocations, but the gene partners were not identified. Eleven novel translocations rearranging band 21q22 with bands 1q25, 2p21, 2q37, 3p21, 3p23, 4q31, 6p24 approximately p25, 6p12, 7p15, 16p11, and 18q21 were detected. Rearrangements of band 21q11 and 21q21 were detected in six novel translocations with 5p15, 6p21, 15q21, 16p13, and 20q11 and with 1p33, 3q27, 5p14, 11q11, and 14q11, respectively. Duplications, triplications, amplifications, and isodicentric chromosomes were detected in eight, three, eight, and three patients, respectively. The present study shows both the wide distribution of the breakpoints on the long arm of chromosome 21 in hematopoietic malignancy and the diversity of the chromosomal rearrangements and the hematologic disorders involved. The findings invite further investigation of the 21q abnormalities to detect their associated molecular rearrangements.
Article: Two Cases of Varicella Zoster Virus Meningitis Found in Pediatric Patients After Bone Marrow Transplantation Despite Valaciclovir Prophylaxis and Without Skin Lesions[Show abstract] [Hide abstract]
ABSTRACT: Two cases of varicella zoster virus (VZV) meningitis are described in an 18-year-old girl and an 18-year-old boy. They occurred, respectively, 9 days and 9 months after allogeneic bone marrow transplantation. VZV nucleic acid was detected in the cerebrospinal fluid during the 1st week of illness. This recurrence occurred despite valaciclovir prophylaxis and without skin lesions. The two patients received aciclovir intravenously and immunoglobulins infusion. They responded to treatment and their clinical state improved rapidly.
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ABSTRACT: We report two cases of visceral larva migrans (VLM) syndrome by Toxocara in children. The biological presentation was unusual and characterized by persistent secondary thrombocytosis (>1,000 x 10(9)/L) mimicking an essential thrombocythemia and variable hypereosinophilia syndrome. Both children had non-specific symptoms including abdominal pain, skin rash, and fever. The diagnosis was confirmed by serology. The children were treated with either thiabendazole or albendazole, resulting in normalization of eosinophil and platelet counts.
Article: Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: Results of EORTC studies 58881 and 58951[Show abstract] [Hide abstract]
ABSTRACT: In a series of 153 children with T-cell malignancies enrolled in 2 consecutive European Organization for Research and Treatment of Cancer (EORTC) trials, we assessed the HOX11L2 expression and/or the presence of a t(5;14)(q35;q32). Additionally, in 138 of these patients, HOX11 expression and SIL-TAL rearrangement were also assessed. These alterations were mutually exclusive, and their frequency was 23% (n = 35), 7% (n = 10), and 12% (n = 17), respectively. HOX11L2/t(5;14) positivity was more frequent in acute lymphoblastic leukemia (ALL) with cortical T immunophenotype and in children aged between 6 and 9 years. In contrast with previously reported data, patients positive and negative for HOX11L2/t(5;14) were comparable with regard to clinical outcome as well as to the response to a 7-day prephase treatment or to residual disease at completion of induction therapy. The 3-year event-free survival (EFS) rate (+/- SE percentage) for patients positive and negative for HOX11L2/t(5;14) was 75.5% (+/- 8.1%) and 68.3% (+/- 5.0%), respectively; the hazard ratio was 0.84 (95% confidence interval, 0.40-1.80). Patients with HOX11-high expression and those with SIL-TAL fusion had low levels of residual disease at the end of induction and a favorable prognosis: the 3-year EFS rate was 83.3% (+/- 8.5%) and 75.3% (+/- 12.6%), respectively. The results obtained in HOX11L2/t(5;14) patients in this study do not confirm the unfavorable prognosis reported in previous studies.
Article: Acute Megakaryoblastic Leukaemia: A National Clinical and Biological Study of 53 Adult and Childhood Cases by the Groupe Français d'Hématologie Cellulaire (GFHC)[Show abstract] [Hide abstract]
ABSTRACT: Since the WHO classification of haematological malignancies recommended the description of global entities, we performed a national M7-AML study to correlate morphological, immunological and cytogenetic features, and to find new clinically relevant M7 entities. This study is based on accurate morphological and immunological study to select pure megakaryoblastic proliferations and to eliminate megakaryocytic participation in haemopathies. We collected 53 cases: 23 adults and 30 children. We confirm the wide heterogeneity of adult M7. In adults, the cytogenetic abnormalities are frequently those of secondary leukaemia while a few patients have a previous history and morphological features of dyshaematopoiesis; their outcome is very poor. Among children, besides the well-known Down syndrome M7, we in particular, studied ten t(1;22) M7 and one OTT-MAL transcript positive case with normal karyotype presenting specific features. We were already aware of their younger age, female and tumoral presentation, but we also found a lower percentage of bone marrow blasts, sometimes without any megakaryoblastic bone marrow involvement, but always, with a dysmegakaryocytopoiesis associated with micromegakaryocytes. They are generally good responders to intensive AML chemotherapy with very long disease-free survivals (DFS). Accordingly, OTT-MAL transcript study, in infant M7 with normal karyotype, is recommended and we feel that this entity should be added to the WHO AML classification.
Article: Cytogenetic profile of childhood and adult megakaryoblastic leukemia (M7): A study of the Groupe Fraņais de Cytogénétique Hématologique (GFCH)[Show abstract] [Hide abstract]
ABSTRACT: To draw the cytogenetic profile of childhood and adult acute megakaryoblastic leukemia (M7), the Groupe Français de Cytogénétique Hématologique collected 53 cases of M7 (30 children and 23 adults). Compared to other acute myeloid leukemias, M7 is characterized by a higher incidence of abnormalities, a higher complexity of karyotypes, and a different distribution of abnormalities among children and adults. Nine cytogenetic groups were identified: normal karyotypes (group 1), patients with Down syndrome (group 2), numerical abnormalities only (group 3), t(1;22)(p13;q13) or OTT-MAL transcript (group 4), t(9;22)(q34;q11) (group 5), 3q21q26 (group 6), -5/del(5q) or -7/del(7q) or both (group 7), i(12)(p10) (group 8), and other structural changes (group 9). Groups 1, 2, 3, and 4 were exclusively composed of children (except one adult in group 3), whereas groups 5, 6, 7, and 8 were mainly made up of adults. The main clinical and hematologic features of these groups were described. No new recurrent abnormality was identified, but mapping of all breakpoints allowed us to specify several possible hot spots of rearrangement: 17q22-23, 11q14-21, 21q21-22, and 16q21-22-23. Although 90.5% of cases had no documented antecedent hematologic disorder or exposure to chemotherapy or radiotherapy, the morphologic and the cytogenetic findings indicated that M7 might be a secondary leukemia more often than suggested by preceding history, particularly among adults. The concurrent analyses of morphologic and cytogenetic data also led us to assume that the initial precursor involved might be more immature in adult than in childhood M7.
Article: Leroux D, Mugneret F & Callanan M et al. CD4(+), CD56(+) DC2 acute leukemia is characterized by recurrent clonal chromosomal changes affecting 6 major targets: A study of 21 cases by the Groupe Francais de Cytogenetique Hematologique. Blood99: 4154-4159[Show abstract] [Hide abstract]
ABSTRACT: CD4(+), CD56(+) DC2 malignancies constitute a novel disease entity, which has recently been shown to arise from a transformed lymphoid-related plasmacytoid dendritic cell (DC2). Diagnosis is primarily based on a particular immunophenotype with tumor cells expressing CD4 and CD56 antigens in the absence of common lymphoid or myeloid lineage markers. Little is currently known about the cytogenetic features of this disease entity. In this setting, the Groupe Français de Cytogénétique Hématologique (GFCH) initiated a cytogenetic study of 18 adults and 3 children with CD4(+), CD56(+) DC2 acute leukemia using conventional and fluorescence in situ hybridization/24-color karyotyping. Clonal, mostly complex chromosome aberrations were found in 14 patients (66%). Six major recurrent chromosomal targets were defined. These were 5q, 12p, 13q, 6q, 15q, and 9, which were involved in 72% (5q), 64% (12p and 13q), 50% (6q), 43% (15q), and 28% (monosomy 9) of cases, respectively. Cytogenetic features can be summarized as follows: (1) gross genomic imbalances (mostly losses) predominate, (2) no single anomaly can be considered as specific, whereas their combination/accumulation is, and (3) both lymphoid and myeloid lineage-associated rearrangements are observed in unusual combinations in the same cell. This is suggestive of complex multistep tumorigenic mechanisms and is supportive of the hypothesis that CD4(+), CD56(+) DC2 acute leukemia may arise from an undifferentiated nonmyeloid nonlymphoid progenitor cell. In conclusion, the present study documents for the first time the existence of a characteristic cytogenetic profile for this novel disease entity.
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University of LyonLyons, Rhône-Alpes, France
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Université Paris 13 NordВильтанез, Île-de-France, France


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Patty is a light brown tabby with a cream neck and tummy and lovely green eyes. She is quite diminutive, has dainty little paws which indicates she is always going to be a little girl. Patty was the most shy when she arrived and hid for over a month. She now greets me at the door and rubs my ankles and has even begun to 'hug' with both arms! Petting is now allowed. She's very playful and loves to bat balls and stuffed toys around especially if they're on a string and you dangle them in front of her. In fact, that's how she decided to come out of hiding and have a good time. The favorite 'toy' now is a long fabric tube that makes noise and lights up as they run through it.
Patty might do best with an adopter that would give a home to Patty and Laverne together but I'm sure will warm up to kind attention...and good food...very quickly. Despite the stressful and scary situation of the transition from hoarder house to animal control to her foster home, Patty has never growled, hissed, bitten or scratched. approx DOB August 2011
Stage one of our mission is getting needy cats off the streets of St. Louis and into caring Foster Homes, where they await their forever homes. Stage two´s goal is to open a shelter building that will house special-needs kitties in a cage-free, no-kill setting until they can be carefully placed in their forever homes.
Please visit our website, www.tenthlifecats.org


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In the medical tent
Friday, October 05, 2012 3:21 PM
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DeSales University and Cedar Crest College nursing students work in a tent after performing triage on victims during a disaster and casualty drill for DeSales University nursing students, emergency personnel, and local emergency response teams. Express-Times Photo | MATT SMITH
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Just spotted this email on my inbox from the folks at Umami Burger: � "Umami Burger Laguna Beach is opening on Wednesday, June 13 at 1 PM at 610 N. Coast Highway."
This will be Umami's second location in Orange County. � Earlier this year, the Los Angeles burger sensation opened at The Camp in Costa Mesa. A third location is planned in Anaheim.
More food news: Follow� Nancy Luna on� Facebook I� Fast Food Maven blog� I Twitter
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DJ Foster talks recruiting after big win
Tags: Recruiting, football, Press and News, 2014, D.J. Foster, Alabama, Auburn, Boise State, California, Florida, Florida State, Georgia, Indiana, Iowa, Iowa State
The final class 0f 2014 state rankings
#1 Omaha North is 6-0
Husker commits shine
HOL ranks the top High School football prospects
D.J. Foster talks about decision to commit to NU
State Track Recap
The no.1 ranked prospect in NE shows his skills
D.J. Foster and Luke Gifford lead the Knights


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Pre-Made Background 3 by Smoko-StockWatch
©2009-2016 Smoko-Stock
Long time no see!! Used this Awesome stock here! revande.deviantart.com/art/Rem… Thanks so very much! I appreciate it!
Do you maybe have a Version of this Background whats a little bit bigger?
Hi just letting you know I put the picture below on my tumblr ( I don't know how to link to it tho) Have credited you & intano-stock
Él utilizado Do imagen aqui, perdon porción no notificarselo sí me paso porción alto joseardid53.deviantart.com/art…
beautiful scenary
been searching for something like this for ages - pure magic - downloaded but will notify when I use it
Awesome bg!


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What does WLRB stand for?
What does WLRB mean? This page is about the various possible meanings of the acronym, abbreviation, shorthand or slang term: WLRB.
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AM-1510, Macomb, Illinois
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Inspiring Recovery
Linda Caldwell
The Writers' Colony at Dairy Hollow is offering a fellowship to an emerging or established writer working on a nonfiction project concentrating on mental health issues, focusing particularly on recovery from, and reconstructing aspects of a healthy life while living with, mental health challenges.
The Fellowship entitles the recipient to a two-week stay at the Writers' Colony at Dairy Hollow, in beautiful and charming Eureka Springs, Arkansas. Each resident has a private suite with writing space, private bath, bedroom and wireless Internet. The residency provides uninterrupted writing time, with dinner prepared five nights a week and served in our community dining room. Residents also share the camaraderie of other professional writers and artists when they want it, and a community kitchen stocked with the basics for breakfast and lunch.
Residencies for this fellowship must be completed by July 31, 2016.
Final application date for entry to be postmarked is July 31, 2015. The recipient will be announced in early September. Fellowship applications must be accompanied by two references and a non-refundable $35 application fee. For an application, click on Apply and then on Fellowships.


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President Obama's debt commission met this summer and painted a bleak picture of the national budget. The bipartisan group called our current situation fiscal "cancer" and warned that it will "destroy the country from within." Americans are right to be concerned with our huge national debt. What is the solution? Erskine Bowles, President Clinton's Chief of Staff, put it simply: "We've got to cut spending or increase revenues or do some combination of that."
Bowles is right. Note that he said "increase revenues," and not "increase tax rates." He probably went with this phraseology because it sounds better—after all, who wants to talk about raising taxes? But the difference goes beyond semantics. Raising tax rates isn't the answer to the budget problem, because it would pull more resources out of the already-suffering private sector. Increasing revenues can happen even without a change in tax rates, if the economy begins growing again.
Unfortunately, many in Congress seem focused on raising taxes rather than increasing revenues as the key to closing the deficit. The Bush tax cuts are set to expire at the end of this year, and Democratic leaders want to blame the Bush tax cuts for today's budget crisis. According to the Congressional Budget Office, the Fed would miss out on $115 billion in tax revenues in 2011 if the Bush tax cuts were to stay in place, and increasing amounts after that.
Yet the reality is more complicated than that. Assumptions about how much could be raised with higher tax rates ignore how tax rates affect behavior and the economy more broadly.
Basically, income tax revenues rest on two main variables: the amount of taxable income and the tax rate.
Mathematically, the higher the two variables are, the greater their product will be. But in reality, these two variables aren't independent: tax rates affect the size of the tax base. When individuals decide how much to work, they consider how much money the government will take from their additional earnings. If the government takes away too much, people have less reason to work harder. This dynamic means that tax rates actually affect behavior.
This is particularly important to consider today, given our current economic predicament. The U.S. is suffering not just from a historic deficit, but a sluggish economy that's failing to produce jobs. Higher rates of taxation discourage hard work, savings, investment, and entrepreneurship – the foundations of economic growth that will create a larger tax base.
Rush Limbaugh defends Rubio's debate answer: He's absolutely right that Obama knows what he's doing | Allahpundit
Time for Team Hillary to break out the gender card for young liberal women who prefer Sanders | Allahpundit


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At Sg2, we tout the power of standardization and minimizing variation, but we also recognize that variation, in terms of volume fluctuations, medical care trends and catering to the varied needs of patients is a day-to-day reality. Fluctuating service volumes and case mix create performance complexities, affecting current operations and revenue cycles and influencing future strategic initiatives. The key to successfully navigating care fluctuations is to discern meaningful and actionable information from statistical noise in assessing data, recognizing patterns, managing what you can manage and preparing for what you cannot.
Obstetrics and Other Examples
In my world of obstetrics, where more than 4 million babies are born nationwide every year, accounting for approximately 13% of adult admissions, fluctuations in volume and changes in case mix significantly impact day-to-day management and long-term strategic planning for obstetrics leaders. Here are just a few examples of the variations inherent in obstetrics, according to the US Centers for Disease Control and Prevention:
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The racing icon's emotional acceptance speech came as he revealed the death of his close friend at an wards ceremony in Birmingham
People aged between 16 and 25 chose some historic icons along with YouTube and sports stars
Just hours before Justin's death he had posted a message on his Twitter account sending his prayers to the driver's family
It's not every day a blind person gets behind the wheel on a circuit raced by the Formula 1 greats, but these drivers loved it
"With the backing of Mercedes he can, maybe, go on to challenge Michael Schumacher's record," said Mansell
The Mercedes ace insists he hasn't demanded a pay rise and if he wins third title he doesn't see himself in same class as his idols Senna or Fangio
Hamilton claimed his second world title this season in fine style and he beat Rory McIlroy in the public vote
29-year-old poised to eclipse Nigel Mansell's 31 Grand Prix victories this weekend in Texas says he's concentrating on the title
Nico Rosberg flatspotted his tyres in the very first lap forcing him to relinquish his lead to the Brit who stormed to a 17-second victory
King James dominated headlines in America since announcing his return to the Cleveland Cavaliers, but he wasn't the first high-profile athlete to go home
The 29-year-old former F1 world champion said: "I admire Nigel greatly for all his success, s
o for him to think I've been close to perfection this year is incredible."
How does current champions Sebastian Vettel compare with the greats of the past like Michael Schumacher, Ayrton Senna or Juan Manual Fangio?
The famous photo of the late Sir Tom Finney sliding through a puddle is one of Oliver Holt's favourite sports pictures - what's your favourite sporting snap?
The 1992 champion said drivers were "not jockeys" and that the move would discriminate against bigger competitiors
The Frenchman had a heated relationship with Ayrton Senna at McLaren, but believes the 2014 Ferrari pair can "work very well"
It's a fourth-successive start from the front for the Brit, who is moving back into world championship contention
It 1992 F1 world champion was known for his daring moves on the track... and for having one of the best-known moustaches
Chris Bennion watched the second episode of Celebrity Masterchef. He's seen the first one, too. He's the voice of Celebrity Masterchef experience
Thirteen British drivers have won the British Grand Prix - and here are the top ten from down the years, including Hamilton's in 2008
See the very best images from 64 British Grand Prix ahead of round eight of this year's Formula 1 world championship
Merecedes F1 ace Lewis Hamilton chats to Oliver Holt about his admiration for F1's bygone era, and how he would have loved to race the likes of Ayrton Senna, Alain Prost and Nigel Mansell
The Brit beat Sebastian Vettel into third by a nose, while there was success for Jenson Button who dragged his struggling McLaren into fifth
F1 legend says today's racers are free to compete without the same risk he contended with as a world champion in the 1980s
Pastor Maldonado fined after his second controversial on-track clash in two Grands Prix
See legends like Jim Clark, Stirling Moss, Graham Hill, Jackie Stewart and John Surtees in our amazing gallery
Team tradition has seen all trophies put on show at the Woking factory, but the Brit wants that to change
In his new series titled Rear View Mirror, MirrorSport's Rob Burnett takes a look at some of the best grands prix around the streets of the principality
Petrolheads rejoice! This weekend sees two of the world's biggest motor races held on the same day, with the Monaco Grand Prix and the Indianapolis 500 taking place this Sunday
Pastor Maldonado's victory would have been the lead F1 story of the day, but a pitlane fire in the victorious Williams team garage overshadowed the on-track events at Barcelona
On the 18th anniversary of his death Byron Young considers how Ayrton Senna would have behaved in today's circumstances.


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Kharn at Armatura by slaine69Watch
©2014-2016 slaine69
A pretty angry kharn.
Kharn: FOR THE LAST TIME!!!!!!!!!! WHO HID MY WHOPPER!!!!!!!!!!!!!!!!!!!!!!!!
Ahriman: hehehehehe just as planned
Ahriman: hehehehehe just as planned
I didn't know Kharn had hair. I assumed that was just a long beard in braids he had coming out of his helmet.
I think I formed an image of him in my head after listening to butchers nails and in that he had hair (the image in my head not the story) and when I heard he was actually bald I though 'oh, right, welll thats boring' so I justify his hair as being something that is less of a priority to kharn than mutilation of enemies and the constant pain of the nails, he kinda lets him self go a bit ya know then on rare occasions of lucidity he's like 'holy tits I look a mess' and shaves his head. Of course I wouldn't have to justify it if GW stopped making everyone bald.
Actually here is a new Kharn model that depicts him in the Horus Heresy and definitely portrays him as bald
That does sound like a good theory. And not everybody is bald. That's just Chaos propaganda messing with you. There's Leman Russ and the SpaceWolves, the White Scars, the Blood Angels, a couple of Black Templars, and of course, the hairetics of the Blood Ravens.
I just read on 1d4chan about ideas Games Workshop should do to stop losing profits, and make things better for themselves. One of them was make a good 40k game or movie that didn't involve their favorite faction. And did I had the idea. They should make a game, or at least a movie, about Kharn. The plot could be that heck of a guy leads a massive warband of World Eaters and regular cultist, and starts killing everything inhabiting the same biosphere with them. Throw in the Ultramarines, and at the end of the game, they lose half of their chapter. Papa Smurf has injuries almost bad enough to be put into a dreadnought, and gets verbally torn a new one by Kharn about the Ultramarines treating the Codex like a book written by the Emperor, and Kharn lives to kill another day. And they should make it canon. This would troll Matt Ward, remove the Ultrasmurfs' Mary Sue status, and possibly give them character development, making them reflect on how the Codex got a lot of them killed. Also, this game would be popular. You get to be Kharn, and you get to kill Ultramarines! For a good measure, have Kharn ride a Carniflex like a bull rider would a bull, and have this as the cover art, with dead Ultramarines to get a lot of Ultrasmurf haters to buy it, and again, to troll Matt Ward.
i agree Platinum Games should make a 40k hack and slash game starring Kharn and Lelith because it would be pretty interesting for the two for the two of them to interact with Lelith flirting with Kharn and Kharn ignoring Lelith
I don't know who Platinum Games is, I think, and my memory is rusty on that Lelith person. I would like it if a game company that's famous for amazing graphics, game mechanics and gameplay would make it. Didn't Relic make Space Marine? I read that Space Marine isn't liked for its graphics, and some stuff about the game mechanics.
Platinum Games is the studio that did Bayonetta and Metal Gear Rising:Revengeance
and as for Lelith here are two links on that is for fun and one for actual fluff
and as for Lelith here are two links on that is for fun and one for actual fluff
Oh, now I remember her. As for the game company, never played those games before.
it would be really cool for a 40k game to star Kharn and Lelith plus it would be funny if their fights are like a married couple arguing
so would it be a good idea for a 40k game to star Kharn and Lelith plus it would be fun if their fights are just like a married couple bickering
It would. I wonder who would be a good voice actor for Kharn.
how about Patrick Seitz or Alastair Duncan or David Hayter
(Scorpion, Senator Armstrong and Solid Snake respectively)
Patrick Seitz can be a great enraged Kharn
Alastair Duncan could be a hammy Kharn
while David Hayter can be a calm and angry Kharn
(Scorpion, Senator Armstrong and Solid Snake respectively)
Patrick Seitz can be a great enraged Kharn
Alastair Duncan could be a hammy Kharn
while David Hayter can be a calm and angry Kharn
sorry i accidentally sent another one
ooh don't get me started on what I'd do for a warhammer film man, I've already started picking primarch actors hee hee
Neat. If such a game comes out, Scot McNeil(Sindri's voice actor) and Mark Strong better be in it. I'd watch a Warhammer film. I don't know that much about it and its history, but I do know some characters and about the setting. The game would be complete if the heck of a guy meme was said in it.
Heck of a guy that Kharn.
Oh God, I just finished up the part about Armatura in Betrayer, this is just great!
Thanks man, Aye that's a great part in the book, hey did you notice Raum lurking in the background?
Oh Kharn, you well-balanced and mentally-stable person you!
Wow, amazing! Blood for the Blood God!!! (?)
Looks great, i like all the blood. The spit spewing out gives him that extra angry feel lol
It is very good .
Well he is a World eater, they're a pretty angry lot.
Aye! their Primarch isn't called chilledoutgron after all.
Well, that's not far from what others imagined: www.deviantart.com/art/Kharn-2…
And what I imagined: 40kwarlord.deviantart.com/art/…
What a great guy.
Good ol' pre-heresy days, amazing work!
Awesome! But I thought he had a shaved head with a topknot, like Abaddon.
I don't think we've had a picture of Kharn's face yet. Shame really because for a raging homocidal monster when the mood takes him, he's a likeable character.
Vicious, brutal and absolutely fantastic!
First time I see a helmet-less Kharn He looks so cool!
Thanks man, it was a bit of a toss up cuz I bloody love his heresy helmet.
My pleasure, I love this pre-heresy version without helmet because the internet is already filled with the post-heresy masked one. Your choice to make it different was a wise one in my opinion, the viewer can actually feel his rage through his expression now