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Publications (17)54.38 Total impact
Article: Cucurbitacin I Elicits the Formation of Actin/Phospho-Myosin II co-Aggregates by stimulation of the RhoA/ROCK Pathway and inhibition of LIM-Kinase[Show abstract] [Hide abstract]
ABSTRACT: Cucurbitacins are cytotoxic triterpenoid sterols isolated from plants. One of their earliest cellular effect is the aggregation of actin associated with blockage of cell migration and division that eventually lead to apoptosis. We unravel here that cucurbitacin I actually induces the co-aggregation of actin with phospho-myosin II. This co-aggregation most probably results from the stimulation of the Rho/ROCK pathway and the direct inhibition of the LIMKinase. We further provide data that suggest that the formation of these co-aggregates is independent of a putative pro-oxidant status of cucurbitacin I. The results help to understand the impact of cucurbitacins on signal transduction and actin dynamics and open novel perspectives to use it as drug candidates for cancer research.
Article: Structural Basis for the Association of MAP6 Protein with Microtubules and Its Regulation by Calmodulin[Show abstract] [Hide abstract]
ABSTRACT: Microtubules are highly dynamic αβ-tubulin polymers. In vitro and in living cells, microtubules are most often cold and nocodazole sensitive. When present, the MAP6/STOP family of proteins protects microtubules from cold and nocodazole induced depolymerization but the molecular and structure determinants by which these proteins stabilize microtubules remain under debate. We show here that a short protein fragment from MAP6-N which encompasses its Mn1 and Mn2 modules (MAP690-177) recapitulates the function of the full-length MAP6-N protein toward microtubules, i.e. its ability to stabilize microtubules in vitro and in cultured cells in ice-cold condition or in the presence of nocodazole. We further show for the first time, using biochemical assays and NMR spectroscopy, that these effects result from the binding of MAP690-177 to microtubules with a 1:1 MAP690-177:tubulin heterodimer stoichiometry. NMR data demonstrate that the binding of MAP690-177 to microtubules involve its two Mn modules but that a single one is also able to interact with microtubules in a closely similar manner. This suggests that the Mn modules represent each a full microtubule binding domain and that MAP6 proteins may stabilize microtubules by bridging tubulin heterodimers from adjacent protofilaments or within a protofilament. Finally, we demonstrate that Ca(2+)-calmodulin competes with microtubules for MAP690-177 binding and that the binding mode of MAP690-177 to microtubules and Ca(2+)-calmodulin involves a common stretch of residues on the MAP690-177 side. This result accounts for the regulation of microtubule stability in cold condition by Ca(2+)-calmodulin.
Article: Mapping the Conformational Stability of Maltose Binding Protein at the Residue Scale Using Nuclear Magnetic Resonance Hydrogen Exchange Experiments[Show abstract] [Hide abstract]
ABSTRACT: Being able to differentiate local fluctuations from global folding-unfolding dynamics of a protein is of major interest for improving our understanding of structure-function determinants. The maltose binding protein (MBP), a protein that belongs to the maltose transport system, has a structure composed of two globular domains separated by a rigid-body "hinge bending". Here we determined, by using hydrogen exchange (HX) nuclear magnetic resonance experiments, the apparent stabilization free energies of 101 residues of MBP bound to β-cyclodextrin (MBP-βCD) under native conditions. We observed that the last helix of MBP (helix α14) has a lower protection factor than the rest of the protein. Further, HX experiments were performed using guanidine hydrochloride under subdenaturing conditions to discriminate between local fluctuations and global unfolding events and to determine the MBP-βCD energy landscape. The results show that helix α4 and a part of helices α5 and α6 are clearly grouped into a subdenaturing folding unit and represent a partially folded intermediate under native conditions. In addition, we observed that amide protons located in the hinge between the two globular domains share similar ΔG(gu)(app) and m values and should unfold simultaneously. These observations provide new points of view for improving our understanding of the thermodynamic stability and the mechanisms that drive folding-unfolding dynamics of proteins.
Article: Phosphorylation Controls the Interaction of the Connexin43 C-Terminal Domain with Tubulin and Microtubules[Show abstract] [Hide abstract]
ABSTRACT: Connexins are structurally related transmembrane proteins that assemble to form gap junction channels involved in the mediation of intercellular communication. It has been shown that the intracellular tail of connexin43 (Cx43) interacts with tubulin and microtubules with putative impacts on its own intracellular trafficking, its activity in channel communication, and its interference with specific growth factor signal transduction cascades. We demonstrate here that the microtubule binding of Cx43 is mainly driven by a short region of 26 amino acid residues located within the intracellular tail of Cx43. The nuclear magnetic resonance structural analysis of a peptide (K26D) corresponding to this region shows that this peptide is unstructured when free in solution and adopts a helix conformation upon binding with tubulin. In addition, the resulting K26D-tubulin molecular complex defines a new structural organization that could be shared by other microtubule partners. Interestingly, the K26D-tubulin interaction is prevented by the phosphorylation of K26D at a src kinase specific site. Altogether, the results elucidate the mechanism of the interaction of Cx43 with the microtubule cytoskeleton and propose a pathway for understanding the microtubule-dependent regulation of Cx43 gap junctional communications and the involvement of Cx43 in TGF-β signal transduction.
Article: The state of the guanosine nucleotide allosterically affects the interfaces of tubulin in protofilament[Show abstract] [Hide abstract]
ABSTRACT: The dynamics of microtubules is essential for many microtubule-dependent cellular functions such as the mitosis. It has been recognized for a long time that GTP hydrolysis in αβ-tubulin polymers plays a critical role in this dynamics. However, the effects of the changes in the nature of the guanosine nucleotide at the E-site in β-tubulin on microtubule structure and stability are still not well understood. In the present work, we performed all-atom molecular dynamics simulations of a αβα-tubulin heterotrimer harboring a guanosine nucleotide in three different states at the E-site: GTP, GDP-Pi and GDP. We found that changes in the nucleotide state is associated with significant conformational variations at the α-tubulin N- and β-tubulin M-loops which impact the interactions between tubulin protofilaments. The results also show that GTP hydrolysis reduces αβ-tubulin interdimer contacts in favor of intradimer interface. From an atomistic point view, we propose a role for α-tubulin glutamate residue 254 in catalytic magnesium coordination and identified a water molecule in the nucleotide binding pocket which is most probably required for nucleotide hydrolysis. Finally, the results are discussed with reference to the role of taxol in microtubule stability and the recent tubulin-sT2R crystal structures.
Article: NMR characterization and molecular modeling of fucoidan showing the importance of oligosaccharide branching in its anticomplementary activity[Show abstract] [Hide abstract]
ABSTRACT: Fucoidan is a potent inhibitor of the human complement system whose activity is mediated through interactions with certain proteins belonging to the classical pathway, particularly the protein C4. Branched fucoidan oligosaccharides displayed a higher anticomplementary activity as compared to linear structures. Nuclear magnetic resonance (NMR) characterization of the branched oligosaccharides and saturation transfer difference-NMR experiment of the interaction with the protein C4 allowed the identification of the glycan residues in close contact with the target protein. Transferred nuclear Overhauser effect spectroscopy experiment and molecular modeling of fucoidan oligosaccharides indicated that the presence of side chains reduces the flexibility of the oligosaccharide backbone, which thus adopts a conformation which is very close to the one recognized by the protein C4. Together, these results suggest that branching of fucoidan oligosaccharides, determining their conformational state, has a major impact on their anticomplementary activity.
Article: Probing Interactions of Tubulin with Small Molecules, Peptides, and Protein Fragments by Solution Nuclear Magnetic Resonance[Show abstract] [Hide abstract]
ABSTRACT: The description of the molecular mechanisms of interaction between tubulin or microtubules and partners at atomic scale is expected to have critical impacts on the understanding of basic physiological processes. This information will also help the design of future drug candidates that may be used to fight various pathologies such as cancer or neurological diseases. For these reasons, this aspect of tubulin research has been tackled since the seventies using many different methods and at different scales. NMR appears as a unique approach to provide, with atomic resolution, the solution structure and dynamical properties of tubulin/microtubule partners in free and bound states. Though tubulin is not directly amenable to solution NMR, the NMR ligand-based experiments allow one to obtain valuable data on the molecular mechanisms that sustain structure-function relationship, in particular atomic details on the partner binding site. We will first describe herein some basic principles of solution NMR spectroscopy that should not be missed for a comprehensive reading of NMR reports. A series of results will then be presented to illustrate the wealth and variety of NMR experiments and how this approach enlightens tubulin/microtubules interaction with partners.
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ABSTRACT: FtsZ is a prokaryotic tubulin-like protein. Despite a low degree of sequence identity with tubulin, it presents the same folding pattern and some similar functions, notably in cell division. Indeed, FtsZ and tubulin polymerize to form bundles and microtubules, respectively, which are essential for cell cytokinesis. We previously demonstrated that peptides derived from the N-terminal stathmin domain interact with tubulin and impede microtubule formation. We demonstrated here that I19L, the most efficient of these peptides, also alters FtsZ bundling assembly in vitro. STD-NMR and TRNOESY experiments revealed that I19L interacts with FtsZ and folds upon its binding but in a way different from what we observed with tubulin. These NMR data were used in molecular modeling calculations to propose models of the I19L-FtsZ complex. Interestingly, two models, consistent with NMR data, show an interaction of I19L near the T7 loop or near the GTP binding site of FtsZ, explaining the modifications of the bundling assembly observed with this peptide. The fine analysis of the structural differences of the complexes of I19L with FtsZ and tubulin should help for the rational development of new specific antibiotic agents.
Article: The PN2-3 Domain of Centrosomal P4.1-associated Protein Implements a Novel Mechanism for Tubulin Sequestration[Show abstract] [Hide abstract]
ABSTRACT: Microtubules are cytoskeletal components involved in multiple cell functions such as mitosis, motility, or intracellular traffic. In vivo, these polymers made of alphabeta-tubulin nucleate mostly from the centrosome to establish the interphasic microtubule network or, during mitosis, the mitotic spindle. Centrosomal P4.1-associated protein (CPAP; also named CENPJ) is a centrosomal protein involved in the assembly of centrioles and important for the centrosome function. This protein contains a microtubule-destabilizing region referred to as PN2-3. Here we decrypt the microtubule destabilization activity of PN2-3 at the molecular level and show that it results from the sequestration of tubulin by PN2-3 in a non-polymerizable 1:1 complex. We also map the tubulin/PN2-3 interaction both on the PN2-3 sequence and on the tubulin surface. NMR and CD data on free PN2-3 in solution show that this is an intrinsically unstructured protein that comprises a 23-amino acid residue alpha-helix. This helix is embedded in a 76-residue region that interacts strongly with tubulin. The interference of PN2-3 with well characterized tubulin properties, namely GTPase activity, nucleotide exchange, vinblastine-induced self-assembly, and stathmin family protein binding, highlights the beta subunit surface located at the intermolecular longitudinal interface when tubulin is embedded in a microtubule as a tubulin/PN2-3 interaction area. These findings characterize the PN2-3 fragment of CPAP as a protein with an unprecedented tubulin sequestering mechanism distinct from that of stathmin family proteins.
Article: Benomyl and Colchicine Synergistically Inhibit Cell Proliferation and Mitosis: Evidence of Distinct Binding Sites for These Agents in Tubulin[Show abstract] [Hide abstract]
ABSTRACT: Benomyl, a tubulin-targeted antimitotic antifungal agent, belongs to the benzimidazole group of compounds, which are known to inhibit the binding of colchicine to tubulin. Therefore, benomyl was thought to bind at or near the colchicine-binding site on tubulin. However, recent mutational studies in yeast and fluorescence studies involving competitive binding of benomyl and colchicine on goat brain tubulin suggested that benomyl may bind to tubulin at a site distinct from the colchicine-binding site. We set out to examine whether colchicine and benomyl bind to tubulin at distinct sites using a human cervical cancer (HeLa) cell line with the thinking that these agents should exert either additive or synergistic activity on cell proliferation if their binding sites on tubulin are different. We found that benomyl and colchicine synergistically inhibited the proliferation of HeLa cells and blocked their cell cycle progression at mitosis. The synergistic activity of benomyl and colchicine was also apparent from their strong depolymerizing effects on both the spindle and interphase microtubules when used in combinations, providing further evidence that these agents bind to tubulin at different sites. Using NMR spectroscopy, we finally demonstrated that benomyl and colchicine bind to tubulin at different sites and that the binding of colchicine seems to positively influence the binding of benomyl to tubulin and vice versa. Further, an analysis of the saturation transfer difference NMR data yielded an interesting insight into the colchicine-tubulin interaction. The data presented in this study provided a mechanistic understanding of the synergistic effects of benomyl and colchicine on HeLa cell proliferation.
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ABSTRACT: We report the NMR assignment of the PN2-3 subdomain of the CPAP protein. It has been previously shown that this motif interacts with tubulin, inhibits microtubule nucleation from the centrosome and depolymerizes taxol-stabilized microtubules.
Article: Both lipid environment and pH are critical for determining physiologic solution structure of 3D- conserved epitopes of the HIV-1 gp41-MPER peptide P1[Show abstract] [Hide abstract]
ABSTRACT: In terms of background, the solution structure of monomeric peptide P1 (residues 649-683), located in the conserved membrane proximal region (MPER) of HIV-1 envelope glycoprotein gp41, is first reported here in dodecylphosphocholine (DPC) micelles. P1 is the minimal MPER region that permits interaction with the mucosal galactosyl ceramide HIV-receptor; it also contains epitopes recognized by major gp41-specific, broadly neutralizing immunoglobulin Gs (IgGs), 2F5 and 4E10, determinant in HIV fusion/infection. Our principal findings were as follows: the structural stability of P1 is pH dependent, as the alpha-helix comprising Q653 I682, present at pH 3.3, is destabilized at higher pH values. At pH 6, the E-rich N-terminal half of P1 (residues 650-666), partially overlapping the 2F5-specific epitope, becomes fully disordered, while the W-rich C-terminal half conserves two shorter helices (W666-W670 and W672-W680), separated by a well-defined bend overlapped by the 4E10-specific epitope. The two IgGs bind to P1 on DPC micelles with binding parameters (K(d)) in the nanomolar range. Next, P1 was derivatized with phosphatidylethanolamine at its C terminal and inserted into liposomes of varied lipid composition, thereby enabling P1 to move laterally. Alternatively, an infectious virus-binding assay was established. The K(d) of both 2F5 and 4E10 IgGs measured on viral liposome and virus are similar and much lower than for the binding of the free peptide. In conclusion, P1, in a lipid environment, is an optimized MPER-derived peptide suitable for designing an immunogen inducing broadly neutralizing antibodies to HIV.
Article: Toward a Better Understanding of the Basis of the Molecular Mimicry of Polysaccharide Antigens by Peptides[Show abstract] [Hide abstract]
ABSTRACT: Protein conjugates of oligosaccharides or peptides that mimic complex bacterial polysaccharide antigens represent alternatives to the classical polysaccharide-based conjugate vaccines developed so far. Hence, a better understanding of the molecular basis ensuring appropriate mimicry is required in order to design efficient carbohydrate mimic-based vaccines. This study focuses on the following two unrelated sets of mimics of the Shigella flexneri 5a O-specific polysaccharide (O-SP): (i) a synthetic branched pentasaccharide known to mimic the average solution conformation of S. flexneri 5a O-SP, and (ii) three nonapeptides selected upon screening of phage-displayed peptide libraries with two protective murine monoclonal antibodies (mAbs) of the A isotype specific for S. flexneri 5a O-SP. By inducing anti-O-SP antibodies upon immunization in mice when appropriately presented to the immune system, the pentasaccharide and peptides p100c and p115, but not peptide p22, were qualified as mimotopes of the native antigen. NMR studies based on transferred NOE (trNOE) experiments revealed that both kinds of mimotopes had an average conformation when bound to the mAbs that was close to that of their free form. Most interestingly, saturation transfer difference (STD) experiments showed that the characteristic turn conformations adopted by the major conformers of p100c and p115, as well as of p22, are clearly involved in mAb binding. These latter experiments also showed that the branched glucose residue of the pentasaccharide was a key part of the determinant recognized by the protective mAbs. Finally, by using NMR-derived pentasaccharide and peptide conformations coupled to STD information, models of antigen-antibody interaction were obtained. Most interestingly, only one model was found compatible with experimental data when large O-SP fragments were docked into one of the mIgA-binding sites. This newly made available system provides a new contribution to the understanding of the molecular mimicry of complex polysaccharides by peptides and short oligosaccharides.
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ABSTRACT: Microtubules are major cytoskeletal components involved in numerous cellular functions such as mitosis, cell motility, or intracellular traffic. These cylindrical polymers of alphabeta-tubulin assemble in a closely regulated dynamic manner. We have shown that the stathmin family proteins sequester tubulin in a nonpolymerizable ternary complex, through their stathmin-like domains (SLD) and thus contribute to the regulation of microtubule dynamics. We demonstrate here that short peptides derived from the N-terminal part of SLDs impede tubulin polymerization with various efficiencies and that phosphorylation of the most potent of these peptides reduces its efficiency as in full-length stathmin. To understand the mechanism of action of these peptides, we undertook a NMR-based structural analysis of the peptide-tubulin interaction with the most efficient peptide (I19L). Our results show that, while disordered when free in solution, I19L folds into a beta-hairpin upon binding to tubulin. We further identified, by means of saturation transfer difference NMR, hydrophobic residues located on the beta2-strand of I19L that are involved in its tubulin binding. These structural data were used together with tubulin atomic coordinates from the tubulin/RB3-SLD crystal structure to model the I19L/tubulin interaction. The model agrees with I19L acting through an autonomous tubulin capping capability to impede tubulin polymerization and provides information to help understand the variation of efficiency against tubulin polymerization among the peptides tested. Altogether these results enlighten the mechanism of tubulin sequestration by SLDs, while they pave the way for the development of protein-based compounds aimed at interfering with tubulin polymerization.
Article: Conformational Studies of the O-specific Polysaccharide of Shigella flexneri 5a and of Four Related Synthetic Pentasaccharide Fragments Using NMR and Molecular Modeling[Show abstract] [Hide abstract]
ABSTRACT: As part of a program for the development of synthetic vaccines against the pathogen Shigella flexneri, we used a combination of NMR and molecular modeling methods to study the conformations of the O-specific polysaccharide (O-SP) of S. flexneri 5a and of four related synthetic pentasaccharide fragments. The NMR study, based on the analysis of 1H and 13C chemical shifts, the evaluation of inter-residue distances, and the measurement of one- and three-bond heteronuclear coupling constants, showed that the conformation of one of the four pentasaccharides is similar to that of the native O-SP in solution. Interestingly, inhibition enzyme-linked immunosorbent assay demonstrated that a protective monoclonal antibody specific for S. flexneri 5a has a greater affinity for this pentasaccharide than for the others. We carried out a complete conformational search on the pentasaccharides using the CICADA algorithm interfaced with MM3 force field. We calculated Boltzmann-averaged inter-residue distances and 3JC,H coupling constants for the different conformational families and compared the results with NMR data for all pentasaccharides. Our experimental data are consistent with only one conformational family. We also used molecular modeling data to build models of the O-SP with the molecular builder program POLYS. The models that are in agreement with NMR data adopt right-handed 3-fold helical structures in which the branched glucosyl residue points outwards.
Article: Synthesis and NMR study of a linear pentasaccharide fragment of the Shigella Flexneri 5a O-specific polysaccharide[Show abstract] [Hide abstract]
ABSTRACT: A convergent chem. synthesis of the Me glycoside of the linear epitope a-D-Glcp-(1->3)-a-L-Rhap-(1->3)-a-L-Rhap-(1->3)-b-D-GlcNAcp-(1->2)-a-L-Rhap (EBCDA) corresponding to the ramification of the O-antigen of Shigella flexneri serotype 5a is described. The strategy relies on the prepn. of a key EB trichloroacetimidate donor and that of an appropriate CDA trisaccharide acceptor. Trichloroacetimidate chem. was used for the construction of all glycosidic linkages except that of DA, where a bromide donor was preferred. In depth anal. of the pentasaccharide EBCDA 1H and 13C NMR spectra shows that its conformation approaches that of the corresponding fragment in the native polysaccharide. [on SciFinder (R)]
Article: Convergent synthesis, NMR and conformational analysis of tetra-and petasaccharide haptens of the Shigella flexneri serotype 5a O-specific polysaccharide[Show abstract] [Hide abstract]
ABSTRACT: Convergent syntheses of the methyl glycosides of the branched pentasaccharide -L-Rhap-(12)-[-D-Glcp(13)]--L-Rhap-(13)--L-Rhap-(13)--D-GlcNAcp [A(E)BCD], featuring the biological repeating unit of the O-specific polysaccharide of Shigella flexneri serotype 5a, and of a related linear tetrasaccharide (EBCD) are described. The strategy, based on the trichloroacetimidate methodology, relied on the use of a key EB disaccharide donor and appropriate CD acceptors. The use of an isopropylidene acetal to block OH-4 and OH-6 of residue D was found to be a suitable alternative to the employment of the more commonly used benzylidene acetal. Conformational analysis of EBCD-OMe and A(E)BCD-OMe was based on analysis of 1H and 13C chemical shifts and inter-proton distances data obtained by NMR spectroscopy. The data showed that residue A had no influence on the conformational behaviour of residue E, although these two residues were involved in a 2,3-cis vicinal glycosylation pattern in A(E)BCD-OMe. Comparison of 1H and 13C chemical shifts of the two oligosaccharides with those of their corresponding sequences in the O-specific polysaccharide of S. flexneri 5a showed that the two oligosaccharides presented a distribution of solution conformations similar to that in the O-specific polysaccharide. The conformation of A(E)BCD-OMe was investigated by two approaches: (i) energy minimisation based on ROE-derived distances with the DISCOVER program and (ii) a conformational searching method (the CICADA algorithm interfaced with MM3 force-field). The minimised conformation obtained by the former approach was in total agreement with the average of the two major families of conformations resulting from the CICADA calculations.
Top Journals
- Biochemistry (4)
- Journal of Biological Chemistry (3)
- Biochemistry (1)
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Université d'Évry-Val-d'Essonne
Évry-Petit-Bourg, Île-de-France, France
- Laboratoire SABNP - Structure-Activité des Biomolécules Normales et Pathologiques
French Institute of Health and Medical Research
Lutetia Parisorum, Île-de-France, France
- Unit of Structure and Activity of Normal and Pathological Biomolecules
University of GrenobleGrenoble, Rhône-Alpes, France


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House debates
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- Higher Education Support Amendment (Asian Century) Bill 2013; Second Reading (1 speech)
I move: That this bill be now read a second time. Asia's transformation into the world's most dynamic economic region is the defining development of our time. This transformation...
- Higher Education Support Amendment (Further Streamlining and Other Measures) Bill 2013; Second Reading (1 speech)
I move: That this bill be now read a second time. The bill will introduce a number of measures to further strengthen and streamline the Higher Education Support Act 2003 (the Act), resulting in...
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Owed To A Tree
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Owed To A TreeOwed To A Tree (1996) Season 1 Episode 8B- Stickin' Around Cartoon Episode Guide by Dave Koch
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- Stickin' Around Cartoon Episode Guide
- Nelvana Limited, Ellipse
- Distributed by: YTV
- Cartoon Characters: Bradley, Lance, Russle, Stella Stickler, Mr. Doddler, Mr. Lederhosen, Stacy Stickler, Stanley Stickler.
- Originally Released in 1996.
- Season: 1
- Color
- Running Time: 11 minutes.
- Canada
Cartoon Summary:
When the city threatens to cut down the very best (and only) climbing tree in the neighborhood, Stacy and Bradley realize the value of "their" tree. The tree has lifted a bit of sidewalk, and someone could trip and sue! The kids see that the tree is not only a place for them to hide and play, but also a place that hides many animals, like squirrels, cats, bugs... In an effort to save the tree, which also happens to be Frank the wiener dog's favorite stop, Bradley and Stacy rally the Latchkey Apartment dwellers around a cause. It takes some tricky business from Bradley to motivate people to come to the tree, but in the end, the city decides to do the good thing and save the tree. Even gives the tree a plaque to ensure its future.
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Left Masthead
February 8, 2016
Beyond Savage Politics and Dystopian Nightmares
Posted on Sep 26, 2013
By Henry A. Giroux, Truthout
(Page 3)
Evidence for the death of the American dream is everywhere: Millions of people have lost their homes, and young people are living with the nightmare of a future without jobs, hopes and security, if not dignity. At the same time, many soldiers returning from the senseless wars in Iraq and Afghanistan and suffering from a wide range of illnesses are given shoddy and sometime death-dealing treatment by the veterans' hospitals. In some cases, they are turned into drug addicts because the hospitals, in their efforts to keep them quiet rather than give them proper treatment, overprescribe painkillers. Unfortunately, such neglect does more than keep them quiet; it often results in their needless deaths. Poor children are denied proper health care and school lunches. The poverty rate in America grows to unimaginable numbers matched only by the increasing growth in income and wealth by the super-rich. The corporate educational reform movement teaches young people how to be stupid and dissolves all vestiges of creativity in the mad frenzy of an audit culture. At the same time, students find themselves in a job market that offers them little but dashed dreams and low-skill jobs, if they are lucky enough to find one.
The small change of human cruelty and a savage politics was evident recently in newspaper accounts about the rise of expensive condos in the Upper West Side of Manhattan that have one entrance for the rich and another for "working people who won a city lottery to obtain affordable apartments in the building." There is a larger politics at work here than the obvious class and racist implications. Connect the dots of this particularly racist and class-based policy to the rapidly proliferating decisions on the part of Tea Party politicians to produce policies that force the frail, poor and aged to choose between medicine and food. Or the decision on the part of the state of Nevada to dump "1,500 mental patients onto other states by putting them on Greyhound busses and sen[ding] them over state lines with no prior arrangements with families or other mental hospitals once they arrive." This is a new kind of authoritarianism that does not speak in the jingoistic discourse of empowerment, exceptionalism or nationalism. Instead, it defines itself in the language of cruelty, suffering and fear, and it does so with a sneer and an unbridled disdain for those considered disposable. Neoliberal society mimics the search for purity we have seen in other totalitarian societies.
Right-wing market fundamentalists want to root out those considered defective consumers and citizens, along with allegedly unpatriotic dissidents. They also want to punish the poor and remove their children from the possibility of a quality public education. Hence, they develop schools that are dead zones of the imagination for most children and highly creative classroom environments free of the frenzy of empiricism and test-taking for the children of the rich. It gets worse. In Pennsylvania, right-wing Gov. Tom Corbett and Philadelphia Mayor Michael Nutter are intent on destroying the public school system. Instead of funding public schools, Corbett and Nutter are intent on crushing the teachers union and supporting vouchers and charter schools. They also are fond of claiming that money can't help struggling public schools as a pretext for closing more than 23 schools "while building a $400 million state prison." As Aaron Kase reports, "Things have gotten so bad that at least one school has asked parents to chip in $613 per student just so they can open with adequate services, which, if it becomes the norm, effectively defeats the purpose of equitable public education, and is entirely unreasonable to expect from the city's poorer neighborhoods."
Vouchers and under-regulated charter schools have become the unapologetic face of a vicious form of casino capitalism waging war on the imagination while imposing a range of harsh and punitive disciplinary methods on teachers and students, particularly low-income and poor white minorities. The vast stores of knowledge and human creativity needed by young people to face a range of social, economic and political problems in the future are not simply being deferred, they are being systematically destroyed. When the emancipatory potential of education does emerge, it is often couched in the deadening discourse of establishing comfort zones in classrooms as a way of eliminating any pedagogy that provokes, unsettles or educates students to think critically. Critical knowledge and pedagogy are now judged as viable only to the degree that they do not make a student uncomfortable. There is more at stake here than the death of the imagination; there is also the elimination of those modes of agency that make a democracy possible. In the face of such cruel injustices, neoliberalism remains mute, disdaining democratic politics by claiming there are no alternatives to casino capitalism.
Square, Site wide
Power in the United States has been uprooted from any respect for public value, the common good and democratic politics. This is not only visible in the fact that 1 percent of the population now owns 40 percent of the nation's wealth or took home "more than half of the nation's income," it is also evident in a culture that normalizes, legitimates and thrives in a politics of humiliation, cruelty, racism and class discrimination. Political, moral and economic foundations float free of constraints. Moral and social responsibilities are unmoored, free from any sense of responsibility or accountability in a permanent war state. Repression is now the dominant mantra for all of society. As Zygmunt Bauman and David Lyons point out, the American public has been turned into "security addicts," ingesting mistrust, suspicion and fear as the new common sense for a security state that seems intent on causing the death of everything that matters in a democracy. The surveillance state works hard to not only monitor our phone conversations or track our Internet communication but to turn us into consumers, ratchet up the desire to be watched, and enforce new registers of social exclusion between those inside and outside the official temples of consumerism, social rights and captainship itself. Confining, excluding and vigilantism is one register of the new face of authoritarianism in the US.
As America enters a historical era dominated by an authoritarian repressive state, the refugee camp as a symbol of exclusion and suffering is everywhere, visible in the material encampments for the homeless, urban ghettoes, jails, detention centers for young people, and in the tents propping up alongside highways that hold the new refugees from the suburbs who have lost their jobs, homes and dignity. The refugee camp also has become a metaphor for those who question authority, because they are increasingly rendered stateless, useless and undesirable. Critical thought is now considered dangerous, discomforting and subject to government prosecution, as is evident in the war being waged against whistleblowers in the name of national (in)security. The technologies of smart missiles hunt down those considered enemies of the United States, removing the ethical imagination from the horror of the violence it inflicts while solidifying the "victory of technology over ethics.
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posted 6 years ago
My pets really like this bed. We have two different ones and they both prefer this one. I do think it's a bit thin but it doesn't seem to bother them. I also like that each side is a different color so you can match your house decor if you'd like.
Pros: Made from recycled plastic bottle
Cons: A bit thin
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These are just good basic mats to have around. They come in a bunch of different sizes and they are light enough to put in crates and carriers. They wash up pretty nice too.
Pros: Sizes and colors
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Grand Lake Club at Southbridge
The amenities of a world-class club in your own backyard. The Grand Lake Club at Southbridge includes a beach entry pool with lap pool and splash pad; a gourmet restaurant and pub; a fitness center and group fitness classes; social events and activities; banquet and wedding facilities; children's activities and more!
Come by and find out more about this unique and beautiful club today.


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Album Reviews
MGMT Dissect "Time to Pretend" on "Song Exploder"
Photo by Danny Clinch
On the podcast "Song Exploder", Hrishikesh Hirway asks artists to break down their songs and discuss how they're made. The ...
January 19, 2016 at 10:26 a.m. EST
Jennifer Herrema Enlists Kurt Vile, MGMT, Hot Chip, More For Installation Soundtrack
Black Bananas and formerly of Royal Trux, recently curated a group of artists for an immersive soundtrack to be used in ...frontwoman of
September 11, 2015 at 8:53 p.m. EDT
Ezra Koenig's Latest Radio Show Features Florence Welch Pranking Ezra, Rashida Jones Rejecting Robin Thicke, More
On the newest episode of Ezra Koenig's radio show "Time Crisis" on Apple Music's Beats 1 radio station, the Vampire Weekend frontman sat ...
July 27, 2015 at 10:26 a.m. EDT
Kid Cudi Performs With MGMT and Haim at Coachella
Photo via Chris Tuite
Kid Cudi, like many other high-profile artists at the same festival, was joined by some guests during his Coachella set yesterday ...
April 20, 2014 at 2:33 p.m. EDT
MGMT Play "Cool Song No. 2" on "Conan"
When MGMT's Andrew VanWyngarden isn't busy recording with Wayne Coyne and Miley Cyrus, he's hitting the late night circuit to promote their ...
April 15, 2014 at 10:11 a.m. EDT
The Flaming Lips and Miley Cyrus Covering the Beatles With MGMT's Andrew VanWyngarden
The Flaming Lips' Wayne Coyne has revealed on Instagram that the band is recording music with Miley Cyrus. The accompanying photo didn't include much ...
March 15, 2014 at 10:15 a.m. EDT
Video: MGMT: "Alien Days"
MGMT have shared a bizarre video for "Alien Days" from their self-titled record, which plays on the differences between past and present, human and alien ...
October 31, 2013 at 3:13 p.m. EDT
Watch MGMT Do "Your Life Is a Lie" on "Jools Holland"
On this week's episode of the British television program "Later... With Jools Holland", MGMT stopped by to deliver a track from their new self-titled ...
October 18, 2013 at 12:38 p.m. EDT
Watch MGMT's "Cool Song No. 2" Video Featuring Michael K. Williams From "The Wire" and "Boardwalk Empire"
MGMT's video for "Cool Song No. 2" from their self-titled album features Michael K. Williams, aka Omar from "The Wire" and Chalky White from ...
September 17, 2013 at 9:56 a.m. EDT
Watch MGMT Play "Plenty of Girls in the Sea" and "Alien Days" on "Fallon"
"wow. @whoisMGMT set a performance standard on tonight's @LateNightJimmy #goFish." So tweeted ?uestlove about MGMT's performance on "Late Night With Jimmy Fallon".
September 12, 2013 at 8:35 a.m. EDT
Watch: NSA Spies On MGMT in Trailer for Upcoming LP, Featuring New Songs
In support of MGMT's upcoming LP, out September 17 via Columbia, the band has shared a short film soundtracked by five new songs. Produced ...
September 4, 2013 at 10:20 a.m. EDT
Photos: Yeah Yeah Yeahs, TV on the Radio, MGMT, Solange, Deerhunter, More at FYF Fest 2013
Photos by Lindsey Best
This year's FYF Fest in Los Angeles included sets by Yeah Yeah Yeahs, TV on the Radio, MGMT, Deerhunter, Solange ...
August 26, 2013 at 5:22 p.m. EDT
Watch MGMT Perform "Your Life Is a Lie" on "Letterman"
MGMT were the musical guests on last night's "Late Show With David Letterman". They performed "Your Life Is a Lie", which is on their ...
August 23, 2013 at 8:05 a.m. EDT
Video: MGMT: "Your Life Is a Lie"
Ben Goldwasser and Andrew VanWyngarden's new MGMT album is self-titled and out September 17 via Columbia Records. Their first video from the record is for ...
August 5, 2013 at 9:37 a.m. EDT
MGMT Reveal New Album Cover
MGMT: "Alien Days" (via SoundCloud)
Ben Goldwasser and Andrew VanWyngarden, aka MGMT, have shared the album cover from the upcoming self-titled album, out September 17 via ...
July 22, 2013 at 10:22 a.m. EDT
MGMT Announce Self-Titled New Album
Photo by Danny Clinch
MGMT: "Alien Days" (via SoundCloud)
Ben Goldwasser and Andrew VanWyngarden have finally announced the new MGMT album. MGMT is out September 17 ...
June 25, 2013 at 9:30 a.m. EDT
MGMT New Song "Something to Do With Prince" Released on Split 7" With Spacemen 3 and Spectrum
Photo by Will Deitz
MGMT: "Alien Days" (via SoundCloud)
Update: According to MGMT's camp, "this release is not currently scheduled."
MGMT will tide listeners over ...
May 3, 2013 at 4:44 p.m. EDT
Watch MGMT Perform a New Song, "Your Life Is a Lie"
Photo by Will Deitz
Yesterday, live video circulated of MGMT playing a new song, "Mystery Disease", at Penn State, and now here's video of ...
May 1, 2013 at 8:20 p.m. EDT
Watch MGMT Perform New Song "Mystery Disease"
MGMT performed at Penn State this weekend, where they debuted some new material from their upcoming album (which is tentatively scheduled for June). As Consequence ...
April 30, 2013 at 11:34 a.m. EDT
Listen: MGMT's Record Store Day Single "Alien Days"
MGMT: "Alien Days" (via SoundCloud)
Happy Record Store Day, everybody. Today, MGMT released a cassette single of their new track "Alien Days". But if you can ...
April 20, 2013 at 2:08 p.m. EDT
Watch MGMT's Bizarre Stop-Motion Preview for "Alien Days", Their Record Store Day Cassette Single
This Saturday is Record Store Day, and MGMT are marking the occasion with a cassette single for an unreleased track called "Alien Days". Now, the ...
April 17, 2013 at 6:16 p.m. EDT
MGMT to Release "Alien Days" Cassette Single for Record Store Day
In celebration of Record Store Day on April 20, MGMT will release a limited edition cassette single that features new song "Alien Days". It will ...
March 11, 2013 at 1:50 p.m. EDT
MGMT Announce Spring Tour
Photo by Will Deitz
MGMT are back. The duo of Ben Goldwasser and Andrew VanWyngarden have announced a spring North American tour, potentially leading up ...
March 4, 2013 at 3:56 p.m. EST
New MGMT Album Tentatively Due in June, Influenced by Aphex Twin
Photo by Will Deitz
The new issue of Rolling Stone features an interview with MGMT, who are readying the follow-up to 2010's bizarre gear-shift ...
January 29, 2013 at 9:59 a.m. EST
Listen: MGMT and Antony Cover Fleetwood Mac
UPDATE: Decca has removed the Soundcloud streams.
Fleetwood Mac: "Future Games" (MGMT cover) (via SoundCloud)
Fleetwood Mac: "Landslide" (Antony Hegarty cover) (via SoundCloud)
We've already heard Best Coast, New Pornographers, and Lykke ...
June 28, 2012 at 10:15 a.m. EDT
Watch the Video for MGMT's "All We Wanted Was Everything"
UPDATE: The video has been taken down.
Back in October, MGMT cuated an edition of the LateNightTales compilation series, for which they recorded a cover ...
November 17, 2011 at 12:09 p.m. EST
Photos: MGMT at the Guggenheim
MGMT played a pair of shows at the Guggenheim Museum in New York last week, with a set composed of new material written specifically in response ...
November 14, 2011 at 12:30 p.m. EST
Watch MGMT Play New Material at the Guggenheim Museum in New York
As previously mentioned, MGMT are playing a pair of shows at the Guggenheim Museum, one of which took place last night. It was the afterparty ...
November 11, 2011 at 5:44 p.m. EST
MGMT Announce Unique Shows at the Guggenheim Museum in New York
MGMT will make two unique appearances at the Guggenheim Museum in New York on November 10 and 11. The MGMT sets coincide with the museum's ...
October 12, 2011 at 4:40 p.m. EDT
Watch: MGMT Cover Pink Floyd on "Jimmy Fallon"
UPDATE: You can barely see him, but it's been confirmed that Deerhunter's Bradford Cox joined MGMT for the performance, dressed as Joey Ramone ...
September 29, 2011 at 9:43 a.m. EDT
The Shins, MGMT, More to Cover Pink Floyd on "Late Night With Jimmy Fallon"
"Late Night With Jimmy Fallon" has assembled a hefty lineup of guests for a week-long Pink Floyd celebration that kicks off on Monday.
September 23, 2011 at 11:35 a.m. EDT
Watch MGMT Get Pelted With Shoes
Here's something you probably shouldn't say when you're on stage in front of a huge crowd: "Everybody give me your left shoe ...
August 8, 2011 at 4:15 p.m. EDT
MGMT Curate LateNightTales Compilation
The LateNightTales compilation series has lined up a big name to curate the next entry in the series: MGMT. Their compilation arrives on October 3 ...
August 2, 2011 at 1:40 p.m. EDT
Watch Flaming Lips Cover "Kids" With MGMT
Photo by Rodrigo Ferrari
This past weekend, the Flaming Lips and MGMT played at the Beale Street Music Festival in Memphis. As Consequence of Sound ...
May 2, 2011 at 4:30 p.m. EDT
News in Brief: MGMT Remixes, Nick Lowe, the Globes, the Wooden Birds, HARD Weekends
-- On March 15, Columbia will release MGMT's Congratulations Remixes EP, a digital-only collection of reworkings of tracks from the band's 2010 album Congratulations ...
March 2, 2011 at 4:10 p.m. EST
Ted Leo, My Morning Jacket, !!!, Yeah Yeah Yeahs, MGMT, Jack White Go All Out for Halloween
Last year, Ted Leo celebrated Halloween by teaming up with some friends in Philadelphia to play an entire show as the horror-punk legends Misfits. Judging ...
November 1, 2010 at 12:55 p.m. EDT
MGMT Respond to Piss Attack Allegations
Photo by Kirstie Shanley
Earlier today, we pointed out some British press reports that MGMT drummer Will Berman had left the stage in Manchester, England ...
September 28, 2010 at 4:55 p.m. EDT
MGMT Reportedly Attacked With Piss
UPDATE: MGMT have responded to these reports.
According to reports, someone in Manchester, England really hated MGMT's set at the Manchester Apollo on ...
September 28, 2010 at 12:35 p.m. EDT
Video: MGMT: "Congratulations"
You're never going to believe this, but the new MGMT video is pretty weird! The clip for "Congratulations" finds the boys wandering through the ...
August 24, 2010 at 11:00 a.m. EDT
Photos: Lollapalooza 2010
Front page photo of the Strokes by Brian Leli; Above: Arcade Fire by Kirstie Shanley
In its sixth year of stationary existence, Lollapalooza 2010 saw ...
August 9, 2010 at 2:25 p.m. EDT
Watch: MGMT Cover the Clean
Those psychedelic pranksters known as MGMT performed a few acoustic songs for Ohio radio station CD101 last week. Along with playing the title track and ...
June 21, 2010 at 2:40 p.m. EDT
New MGMT Video: "It's Working"
For their new video for the Congratulations track "It's Working", MGMT teamed up with So Me, the director behind new-classic videos like Justice's ...
June 15, 2010 at 10:55 a.m. EDT
Watch: LCD, the National, MGMT, Jónsi, Los Campesinos! Play Music on TV
LCD front page photo by Ruvan Wijesooriya, photo on this page by Natalie Kardos
Basically every band you like played a song on TV last ...
May 12, 2010 at 1:00 p.m. EDT
MGMT, Yeasayer, Suckers Members Appear in New Movie Wah Do Dem
If you're in search of this generation's Brooklyn hipster-pop equivalent of Singles (or at least Nick & Norah's Infinite Playlist), there's ...
May 12, 2010 at 9:00 a.m. EDT
MGMT Hit "Saturday Night Live"
This weekend, MGMT brought their tightest suits and their giant lit-up pinwheel to the Studio 8H stage, playing the progged-out Congratulations tracks "Flash Delirium ...
April 26, 2010 at 11:00 a.m. EDT
MGMT Announce World Tour
Congratulations, the loony and idea-jammed album from the crazy-popular Brooklyn psych-pop duo MGMT, drops April 13 via Columbia. (You can hear the whole thing now ...
April 7, 2010 at 11:25 a.m. EDT
Echo Chamber: MGMT
"If the fabled Brooklyn music scene does exist, we're definitely not part of it. Most of those bands are never going to be discovered ...
March 31, 2010 at 1:00 p.m. EDT
MGMT's Batshit "Flash Delirium" Video
Just listening to MGMT's "Flash Delirium"-- with its stylistic change-ups and inexplicable internal logic-- can send you into a fever dream. And now the ...
March 30, 2010 at 9:45 a.m. EDT
Hear MGMT's New Album Right Now
Congratulations, the sophomore album from MGMT, won't be out officially until April 13, but the sprawling, mutating LP is already floating around out on ...
March 22, 2010 at 10:55 a.m. EDT
MGMT, GZA Guest in Trippy New Devendra Banhart Video
EDIT: Ron Winter directed the video below, and Greencard Pictures produced it.
In the adorably tripped-out new video for Devendra Banhart's lilting "Baby", Devendra ...
March 15, 2010 at 4:20 p.m. EDT
Festival Report
Festival Report: Coachella 2014: Photos
Pitchfork; April 15, 2014
Coachella 2014 went down over the weekend, featuring acts such as OutKast, Arcade Fire, the Knife, Beck, the Replacements, and many more. Photographer Chris Tuite was there to take shots ...
Staff Lists
Staff Lists: The Year in Photos 2013
Pitchfork; December 3, 2013
Our year-end coverage kicks off with some of our favorite shots of 2013, including images of Björk (above), Daft Punk, Vampire Weekend, Savages, Lana Del Rey, Arctic Monkeys, Solange, Grimes ...
Cover Story
Cover Story: MGMT
Larry Fitzmaurice; September 11, 2013
With their third album, MGMT continue to chase their psych-rock whims while falling into a musical abyss that's as goofy as it is dark. But will their legion of ...
Staff Lists
Staff Lists: Most Anticipated Releases: Fall 2013
Pitchfork; September 2, 2013
As we head into the fall, we take a moment to gather information about some of the upcoming releases we and our readers are looking forward to. From the Weeknd ...
Staff Lists
Staff Lists: The Worst Album Covers of 2010
Ian Cohen; December 6, 2010
Goofy, offensive, amateurish, and puzzling-- these are the worst album covers of 2010.
Articles: Lollapalooza 2010
Rob Mitchum and Tyler Grisham; August 9, 2010
Lollapalooza 2010 saw nearly as many acts on the Merge/Sub Pop axis as stadium-filling pop stars.
Interviews: MGMT
Ryan Dombal; April 19, 2010
The unlikely hit duo talk about following their breakthrough record with something more difficult and divisive.
Staff Lists
Staff Lists: The Top Music Videos of 2009
Pitchfork; November 30, 2009
We kick off our run of year-end features with a look at the top music videos of 2009.
Staff Lists
Staff Lists: The Top 50 Music Videos of the 2000s
Scott Plagenhoef; August 31, 2009
Our survey of the decade continues with a countdown of the 50 best videos of the 2000s.
Staff Lists
Staff Lists: The Top 500 Tracks of the 2000s: 100-51
Pitchfork; August 19, 2009
Part three of our look at our favorite tracks of the decade.
Staff Lists
Staff Lists: The 100 Best Tracks of 2008
Pitchfork Staff; December 15, 2008
From indie rock to pop to disco to hip-hop, we count down our favorite tracks of the year.
Staff Lists
Staff Lists: Top 40 Music Videos of 2008
Scott Plagenhoef and Mark Richardson; December 4, 2008
Our favorite music videos of 2008.


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Latest news from the Pacific Northwest
Local News
< MyNorthwest
Riders on Washington state ferries up 1.5 percent
SEATTLE (AP) - Ridership on Washington State ferries rose 1.5 percent last year, compared with the year before.
The 22.5 million riders are the most since 2009.
The Kitsap Sun reports ( http://bit.ly/1k7y4TP) the growth was in non-commuters. Commuter use declined.
Vehicle traffic in the San Juan Islands was the highest it's been in a decade.
The Bainbridge Island-Seattle route remains the busiest run on Puget Sound, with more than 6 million riders last year.
Information from: Kitsap Sun, http://www.kitsapsun.com/
(Copyright 2014 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)


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- Full-day tour of Dunedin city center and Otago Peninsula wildlife viewing, from Dunedin
- See Dunedin highlights like Baldwin Street, Otago University, Dunedin Railway Station, the Octagon and Signal Hill lookout
- Visit a yellow-eyed penguin reserve and get up close to this rare penguin species
- Walk around Taiaroa Head to view the northern royal albatross
- Pickup and drop-off available from Dunedin hotels or Port Chalmers cruise port
- Small-group tour with a maximum of 19 people allows customized attention from your guide
Recent Photos of This Tour
What You Can Expect
Customer Reviews
February 2016
Very informative. Excellant guide. Wildlife park was great feeding the animals.
December 2015
Experience tour guide worked at Penguin Reserve - fantastic experience with incomparable views - highly recommend this tour
June 2015
We had a wonderful, wonderful time on this trip. It was rainy, windy, and a little snowy ! in downtown Dunedin the day we were supposed to leave. Les, our tour guide, came to our hotel about an hour before and asked if we wanted to opt out. Like the idiots abroad my wife and I were, we said Ah, it's only a little chilly, the snow is melting as soon as it hits the ground, we'll be fine! Haha, don't make this similar mistake, people! The trip takes you out to some high high places, where the snow that is melting outside your hotel suddenly packs, and out on the peninsula you'll get the full force of the cold southerly oceanic winds. So, with the attitude of the customer is always right Les agreed to wing it and away we went for 7 hours. There were some things which just weren't accesible - we couldn't get all the way up Signal Hill, a winding, winding road which was packed with slippery snow. We couldn't get to the castle as the storm had felled 3 trees along the path though poor beleagured Les tried TWICE, once early in the day and once later in the day to see if the path cleared. What we DID get was an awesome, awesome tour guide who loved Dunedin, knew all about the history, was happy to field any and all questions no matter how weird. It is OBVIOUS Les loves Dunedin and loves to share it with people. And lemme tell you, even in good weather those narrow roads are pretty terrifying, driving up hills so high your ears pop a few times during the trip, and I'm sure some people look at a map from their home in the States and think Gosh we could rent a car and do this ourselves... Well, I don't recommend that at all!! Get someone who has driven those roads before. What did we LOVE? We loved the albatross area with the beautiful ocean views. We loved seeing Dunedin from all sides of the city, looking down. We REALLY loved the beaches. What we really loved was getting a good Dunedin 101 course from Les as we drove. This is an essential trip!
April 2015
We really enjoyed this tour as it included a nice mixture of sites in Dunedin, a visit to the gardens of Larnach Castle, an excellent visit of the fascinating yellow penguin reserve on the Otago peninsula and a brief stop to see the albatross at Taiaroa Head. And in between the guide made several stops for us to admire the breath-taking scenery, e.g. views from on top of Signal Hill in Dunedin of the city, the surrounding hills and the ocean. We also made a number of brief stops on the Otago peninsula - everywhere we looked the scenery was beautiful! The pace of the tour was just right - kept us busy and engaged for a nicely filled day. The only negative was the lunch at Larnach Castle. The site was lovely but we found that the food was pretty poor. Lunch was at our expense but we were disappointed with the quality of the food. Nonetheless, this tour was wonderful and we highly recommend it.
March 2015
An excellent tour.
The guide was attentive and pleasant. Dunedin is lovely, but the nature and sights of Otago were the most amazing parts
A good value, too!
December 2014
It was a lovely tour, our German tour guide was very entertaining. The highlight of the tour was the Penguin place!
January 2016
no penguins --2 lumps of brown


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She loves it, she loves it not! Is Qamar preggers or did she really have an abortion?
It was exactly a week ago that Lebanese actress/singer Qamar revealed the identity of her secret husband! Turns out it's Egyptian actor Mostafa Shaban. And guess what, there's more: she's pregnant with his baby!
However, Mr lova lova totally refuses to believe that the baby is his, according to what Qamar told close friends.
According to Sayidaty.net, contradicting sources reported that Mostafa flew out to Beirut to be by Qamar's side, while others said that the singer has had an abortion!
Some even said that the two have never even met in the first place! When the two were contacted for more info on their mysterious relationship, neither answered the matter in question.
Only time will tell – and we mean a baby bump by that!
Qamar is already the mother of Jamie, who she had through a temporary marriage to Melody TV channels owner Jamal Marwan.
Funnily enough, Marwan also denied the child as his own, despite the large number of lawsuits the two lobbed at each other. Eventually, he won the case!
Top Headlines
- Shakira pregnant? Yes she is, no she isn't
- 8-year-old Yemeni child dies at hands of 40-year-old husband on wedding night
- Nancy says she doesn't really hate Iraqis
- Qamar pregnant by mystery father #2 who also wants nada to do with the baby
- Who wants Qamar dead? Singer narrowly escapes mystery murderer in Beirut


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A BarCamp is where about 100 web geeks spend all weekend together discussing what's hot and what's not, and the latest one has just finished at Ebay's very cool Richmond offices. The idea is to give a chat on any topic , for example I saw one was called "The Art of Stabbing People" - had I made a mistake in turning up in a Microsoft t-shirt, I wondered.
My personal favourite was by Tom Whitwell of the Times OnLine headline writing. He gave a number of top tips to get traffic and interest in what you are doing by being specific, and not being deliberately funny or clever.
My headline of "Ask Microsoft (no stabbing allowed) " got a little interest but was up against "css3" and "Bring your own cool gadgets". Other sessions where on web anonymity, sleeping with the enemy (given by a couple where each is a designer for a competing web company), and loads of web tech hack stuff..
The most controversial session for me was a discussion about pseudonymity i.e. anonymity on the web by improbulus. This person is working as hard as possible to remain invisible (except of course by going to BarCamps!). I can accept the need to be really careful about how much you reveal about yourself, to protect your identity from theft and because there trolls and stalkers out there. But if you are commenting on other peoples opinions or work then surely you should answerable and identifiable in some way. Finally, none of the measures discussed will protect you from any concerted attack on your identity whether lawful or otherwise.
So a really great weekend, I wonder if anyone would come if we did one at our office?
Hi, thanks for your mention of my session & the link. Nice to meet you at BarCamp.
I think you missed the start of my session, when I did emphasise the point that nothing I suggested would guarantee bulletproof anonymity, it would just make it a little bit harder to track you down, so that most people wouldn't bother if you didn't give them a reason to.
I'm still fully contactable by email, phone & post (and lynchable in person at geek events!), & people can respond by comments on my posts or on their own blogs etc if they disagree with something I've said. And I'm starting to drop the pseudonymity, gradually.
I'd certainly come to a BarCamp at MS by the way, as long as it was in the London Victoria premises (I like Windows Live Writer!)
Improbulus, agreed and thanks again for an excellent presentation, I look forward to not photographing you at the next one!
Of course we'd all come round and trash MSFT offices Andrew. Just kidding :-)


text: http://www.icpsr.umich.edu/ 2006-03-30T12:00:00-05:00 Updates to Monitoring the Future: A Continuing Study of the Lifestyles and Values of Youth, 1992 (ICPSR 6133) ICPSR email@example.com ICPSR http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/6133-2006-03-30T01:00:00-05:00 2006-03-30T01:00:00-05:00 2006-03-30T01:00:00-05:00 ICPSR 6133 was updated on 2006-03-30, please download updated files 2006-03-30 File CB6133.ALL.PDF was removed from any previous datasets and flagged as a study-level file, so that it will accompany all downloads. http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/6133-2005-11-04T01:00:00-05:00 2005-11-04T01:00:00-05:00 2005-11-04T01:00:00-05:00 ICPSR 6133 was updated on 2005-11-04, please download updated files 2005-11-04 On 2005-03-14 new files were added to one or more datasets. These files included additional setup files as well as one or more of the following: SAS program, SAS transport, SPSS portable, and Stata system files. The metadata record was revised 2005-11-04 to reflect these additions. http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/6133-1997-12-19T01:00:00-05:00 1997-12-19T01:00:00-05:00 1997-12-19T01:00:00-05:00 ICPSR 6133 was updated on 1997-12-19, please download updated files 1997-12-19 The codebook is now available as a PDF file. http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/6133-1994-03-10T12:00:00-05:00 1994-03-10T12:00:00-05:00 1994-03-10T12:00:00-05:00 ICPSR 6133 was originally relased on 1994-03-10. Original ICPSR release.


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And I love you too, Jul... by Lady2011Watch
©2012-2016 Lady2011
me:*walks up*YO!
this look awesome very nice work indeed.
aww ^^
So romantic! Hope Promy comes back too.
Its like an anime scene Cool! remind me of some of the drawings Ive done a little lol
Rock on Julien. XD
Awwww ^^
Awww that's cute
that's so cute
ps: do you know what happened to him?
ps: do you know what happened to him?
Lovely Perfect Style!
yay!!! is too cute ^3^ ~
Aww, so lovely! I'm hoping he comes back soon too and gets to enjoy this. Lovely drawing of both Julien and Miaka!
its cute


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Should You Cross-Train?
- By Alice
- February 26, 2013
- No Comments
If you want to run harder and race faster, you need to run more… right? Maybe. But sometimes when you increase your running mileage or intensity too much you increase … Continue Reading →
New and Cool: Shrug, Rundies and More
- By Alice
- December 4, 2012
- 3 Comments
OK ladies, we'd like to let you in on a few of our favorite new arrivals here at RW. And guys, if you're already in the zone of holiday shopping, … Continue Reading →


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The Village offers a wide variety of activities, programs and special events throughout the year. To see our most current offerings please download our current L.I.F.E. program guide.
L.I.F.E. (Leisure Is For Everyone) Guide
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Upcoming Family Trips
Please download, complete, and return to the Village Offices with payment. Or save time and register online!
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To register online or learn more about other methods of registration, click here.


text: A motorist traveling at a constant speed of 150 km/h in a 50-km/h speed zone passes a parked police car. Three seconds after the car passes, the police car starts off in pursuit. The policeman accelerates at up to a speed of 30 m/s, and then continues at this speed until he overtakes the speeding motorist. How long from the time he started does it take the police car to overtake the motorist? The motorist continues at a constant speed during this process.


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Yes, but my way.
if it seems like a serious question, then i answer it as best as i can. if i don't have anything more valuable to offer than what someone else has already answered then i skip it.
Before even deciding to answer, I will read a person's question and decide whether their question appears to be sincere. If it's a question that deserves a sincere answer, I usually do my best to answer it with sincerity.

On occasion, I have answered people's questions rather inappropriately (although they did not specify how serious they were at the outset). In those cases, I have replied back to the original writers and expressed my sorrow, or apologies for my not having understood the serious nature of their questions.

Usually, sincere people will understand my reaching out to them, and will reply in kind.

Hope this helps,

AnonymousButCandid.

P.S. If I happen to feel a question is the opposite of serious, I will either not answer it, or will find some "clever" answer to their less-than-serious question.
I usually skip those
Fock no! What is this?
Depends upon the question.
Sometimes I can not help myself.....I must reply with sass.
if they say that spesificly then yes.
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Rose and Thistle Bed and BreakfastUnited StatesNew YorkCooperstown
About this listing
Towels, bed sheets, soap, and toilet paper
Central heating or a heater in the listing
The Space
The Rose and Thistle Bed and Breakfast in Cooperstown, New York is a perfect home base for exploring the Baseball Hall of Fame, Farmer's Museum, Fenimore Art Museum, Glimmerglass State Park and many more attractions.
An enchanting experience awaits you at this turn-of-the-century Victorian Bed and Breakfast. The Rose and Thistle combines Old World charm and new world luxury to let you experience the bed and breakfast in an elegant tradition.
Our cozy Bed and Breakfast offers a warm and welcoming atmosphere. Relax in a wicker glider on the wraparound porch reading a book/newspaper or enjoy a game in the parlor.
We have 4 bedrooms, 3 with a queen bed and 1 with a king to accommodate 2 people per room.
Each bedroom has been charmingly decorated, all with queen beds or king bed, ceiling fans, cable tv, wireless internet, air conditioning and private bath. Each room offers an iron/ironing board, soaps, bottled water.
A Full Breakfast awaits you every morning at 8:30am sharp.
Guest Access
Wi Fi, cable tv, fridge on porch, snacks in dining room, HDTV in parlor
Interaction with Guests
We interact with our guests on a regular basis but also give them their privacy when required.
The Neighborhood
We are a small, quaint village of 1800 residents that attraction thousands of tourists from April through November. We have 3 wonderful museums in our 1 square mile town and also the Glimmerglass Opera as well as being located on a 9 mile lake.
Getting Around
the village is 1 square mile and during the high season, there are trolley to take our guests to all the venue in town.
Smoking on porch only and no pets allowed.


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I remember the days when I used to play my PlayStation all the time rather than go out and hook up with girls and friends of sorts.
I remember wanting to REALLY complete just this one level in order to save the game and head off out to grab my pizza before I get some well deserved rest.
It used to really frustrate me that I just couldn't complete this or that due to the same silly thing happening again and again on the level – and after attempting it for hours, there goes the pad. Smash!


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Logs Stacked Outside Mill Winter Stock PhotoColor Image,Day,European Alps,Firewood,Fossil Fuel,Front View,Fuel and Power Generation,Horizontal,Leaf,Log,Mill,No People,Outdoors,Photography,Plantation,Preparation,Sky,Snow,Stack,Tranquil Scene,Tranquility,Tree,Winter,Wood - MaterialPhotographer Stephen MallonCollection: The Image Bank Austrian Alps


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[JURIST] Iraq's Cabinet on Tuesday approved a draft law creating a national guard in a step toward achieving national unity. The Cabinet also approved a draft law reforming a previous ban on former Baath Party members becoming part of the government. This second draft law proved challenging to pass as … [read more]
[JURIST] The members of Iraq's Independent High Electoral Commission (IHEC) [official website; JURIST news archive] collectively resigned on Tuesday. The Board of Commissioners' resignations were meant to protest political interference [Reuters report] based on conflicting parliamentary and judicial decisions excluding certain candidates from Iraq's upcoming election. Iraq's parliament and judiciary … [read more]
[JURIST] Iraqi police arrested Ahmed al-Awlani, an MP and prominent Sunni supporter of anti-government protests, on Saturday in the city of Ramadi. Awlani, a member of the Sunni supported Iraqiya bloc was reportedly wanted on terrorism charges [BBC report] along with his brother, Ali. Ali and five bodyguards were killed … [read more]
[JURIST] Iraqi police forces on Friday alleged al Qaeda [JURIST news archive] is responsible for the bodies of 18 men found who had been abducted and shot in the head. The victims were taken from their houses [Reuters report] early on Friday morning by men in military uniforms, and among … [read more]
[JURIST] Iraqi authorities on Thursday announced the execution of 42 people [press release, in Arabic] convicted on terrorism charges. The executions took place over the course of two days and bring the total number of executions in Iraq this year to 132. The government of Iraq has been resorting to … [read more]
[JURIST] The Iraq Ministry of Justice [official website, in Arabic] on Monday reported the execution [press release, in Arabic] of 15 men and two women convicted of terrorism. The individuals were convicted under Article 4 [text, PDF] of Iraq's anti-terrorism law, which requires a sentence of death for any who … [read more]
The invasion of Iraq was an initial military success and led to complete destruction of Saddam Hussein's regime. The military forces established the Coalition Provisional Authority (CPA) on April 21, 2003, citing UN Security Resolution 1483 as justification for its assumption of governmental control. Despite violence, the Interim Governing Council … [read more]
Protests in Syria began as candlelight vigils in early February 2011, a sympathetic response to the escalating rebellion in Egypt. HRW released the first reports of violence against demonstrators on February 9, 2011, and stated that Syrian activists were urging civilians to request more freedoms from their government. Protests by … [read more]
While the Syrian conflict began during the Arab Spring of 2011, it was fueled by decades of political oppression. On March 6, 2011, schoolchildren, inspired by uprisings in Egypt and Libya, graffitied anti-Bashir al-Assad messages on several buildings in Daraa. After Syrian police arrested the children, protests erupted in Daraa … [read more]
[JURIST] The UN High Commissioner for Human Rights Navi Pillay [official profile] on Friday condemned [press release] Iraq's execution of 21 prisoners this week, urging the country's compliance with international human rights obligations. Pillay expressed dismay with the numbers of executions carried out in Iraq, noting that the country's criminal … [read more]
[JURIST] The Iraqi Justice Ministry executed 21 individuals on Tuesday who were convicted of terrorism. The men were convicted [CNN report] under Article 4,of Iraq's anti-terrorism law, which includes the use of improvised explosive devices, assassinations of doctors and kidnapping women, and sentenced to death. Iraq has been widely criticized … [read more]
[JURIST] The Iraqi Cabinet announced an amendment to the De-Baathification law on Monday that would allow thousands of former members of Saddam Hussein's now-defunct Baath party [BBC backgrounder; JURIST news archive] to serve in the public sector and receive pensions. The proposed amendment would allow former Baath party branch chiefs … [read more]
JURIST Columnist Haider Ala Hamoudi of the University of Pittsburgh School of Law says that Iraq must not push blindly forward in its goal of de-Ba'athification, but rather consider the harm that such absolute changes pose to fairness and process ...Last month, a special panel of Iraq's highest appellate court … [read more]
[JURIST] An Iraqi judicial panel has rejected the Justice and Accountability Committee's recent decision to remove chief judge Medhat al-Mahmoud from office. The Committee decided remove al-Mahmoud [JURIST report] last over alleged ties to Saddam Hussein's Baath party [BBC backgrounder; JURIST news archive]. The judicial panel, which reviews decisions made … [read more]
[JURIST] Iraq's Justice and Accountability Committee announced Thursday that the country's chief judge Medhat al-Mahmoud has been been removed from his office over ties to Saddam Hussein's Baath party [BBC backgrounder; JURIST news archive]. The committee, which is responsible for removing former Baath party members, explained [AP report] that Wednesday's … [read more]
[JURIST] A draft Iraqi cybercrime law would violate the international standards protecting due process, freedom of speech and freedom of association, Human Rights Watch (HRW) [advocacy website] reported [text, PDF] Thursday. The Information Crimes Law, which had its first reading before the Iraqi Council of Representatives [official website, in Persian] … [read more]
[JURIST] Former Interior Minister of Iraq Mahmoud Thiab al-Ahmed, who served under former dictator Saddam Hussein [JURIST news archive], was released from prison on Tuesday after serving an eight-year sentence for his part in draining the marshes in Southern Iraq. Saddam had accused people living in the marsh areas [Reuters … [read more]
[JURIST] The Iraqi government has executed Abid Hamid Mahmud, a former bodyguard and secretary of Saddam Hussein [JURIST news archive], an official from the Iraqi Justice Ministry said Thursday. Mahmud was sentenced to death [JURIST report] by hanging in 2010 alongside former Iraqi foreign minister and deputy prime minister Tariq … [read more]
[JURIST] Iraq's human rights situation remains fragile [press release], the UN Assistance Mission for Iraq (UNAMI) [official website] reported [text, PDF] Wednesday. Iraq is currently transitioning from a decade-long dictatorship and its underlying armed conflict and violence to a peaceful democratic system. UNAMI recognized some improvements towards such a system, … [read more]
JURIST Contributing Editor Michael Kelly of Creighton University School of Law says that the likely outcome of the withdrawal of coalition forces from Iraq is a backslide into sectarian violence resulting in the split into smaller states based on ethnoreligious geography...The official drawdown of US forces in Iraq yesterday, December … [read more]


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Brooke - sheer green 2 by wildplacesWatch
©2012-2016 wildplaces
lovely Brooke
sexy brooke.
le sigh... rapidly becoming my favorite any plans to get shots of Monday again?
beautiful indeed
WOW, I really like this one, great shot, very pretty model !!!!
Okay, i love the pic from the model's waist up..she is a woman of great beauty no doubt but you ruined the grace of the shot with the blue shirts thingy. How about doimg a reverse color scheme on bottom?pale green panties or swim bottoms with a sheer black skirt. Even though glamour potraits have no limit in the amount of skin they show (which is usually a fair amount) you showed too much..it doesnt entice me to look at it and delve into the picture. And guys who will look at it will pass over it and be like."yeah shes hot" rather than taking time to imagine the clothes off (what every guy does when he sees a covered girl) and be more responsive. And say "shes gorgeous" "this photo is amazing" etc


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FTC: Increase in Tax-Related ID Theft Complaints
March 12, 2012
Kirsten here from AllClear ID. We've talked a lot about identity theft and taxes this year, and now there's a new report from the FTC showing the number of identity theft complaints involving tax and wage fraud is soaring, even as law enforcement tries to crack down on them. Federal Trade Commission officials told the Associated Press "24 percent of the nearly 279,000 identity theft complaints it received in 2011 came from people concerned their Social Security numbers had been stolen and used to fraudulently file for tax refunds or apply for jobs" – an increase of 8% above the previous year.
To protect yourself against identity theft of your tax return, check out our Facebook page with a great download on this topic. The IRS and the FTC also have good guides on how to combat tax fraud.
2 Responses to "FTC: Increase in Tax-Related ID Theft Complaints"
sending people to facebook or other such sites is like sending them into the lions den. Believe it or not there are still a lot of us that will not use such sites.


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National Culinary & Bakery Arts SchoolsRead MoreNational Culinary and Bakery Arts Schools is the perfect place to secure your sugar fix, and with such rave reviews about the bakery, you may find yourself stocking up for winter. It serves everything including gluten-free and low-fat options. National Culinary and Bakery Arts Schools is located near endless parking possibilities, allowing drivers to park with ease. Delicious pastries are baking now at National Culinary and Bakery Arts Schools. Don't miss out! So don't go to any bakery. National Culinary and Bakery Arts Schools is highly-rated for a reason.8400 Center DriveLa Mesa, CA US
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Avivit's Bon PatisseriesRead MoreAvivit Erlichman honed her cake-making skills under world-renowned bakers in the Middle East and the United States, developing a baking philosophy built around beautiful presentation and using only fresh, preservative-free products. Avivit boasts a diverse culinary repertoire; she's able to whip up everything from Israeli cheesecakes, pecan pies, and lemon cakes, to savory couscous, chicken schnitzel, and stuffed peppers. As a proud mother of three, Avivit brings a wealth of experience with children to the kitchen table, helping kids of all ages unlock their creative potential during children's cake-decorating and baking courses.10270 Prairie Fawn DriveSan Diego, CA US
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I dont even.. I hate titles. Anyways, done this during streaming. Was in the mood for mushrooms, so there you go! Mushrooms. Purple mushrooms.
2 1/2 hours on this ~
2 1/2 hours on this ~
Looks like Zangarmarsh on WoW
That is stunning!
Those Mushrooms look awesome
Those Mushrooms look awesome
Gawd, your work keeps getting better and better ;_;
Keep it up!
Keep it up!
shroomy XD
So awesome! I want to live in one
very cool concept!