text:
City Highlights Weekend in Cleveland
Program Number:
Start and End Dates:
8/29/2013 - 9/1/2013
3 nights
Cleveland, Ohio
Price starting at:
$598.00 -
Price may vary based on date, departure city
Program Type:
Independent City Discoveries
6; 3 Breakfasts, 2 Lunches, 1 Dinner
Meal Options:
Perched on the shores of Lake Erie, Cleveland�s thriving cultural scene and charming neighborhoods make it the perfect place to discover over a long weekend. Join a local expert for a walk along the Public Square and admire the city�s impressive architecture. Marvel in the array of produce and gourmet foods at the West Side Market, and attend a show-stopping theatrical production at Playhouse Square. Along the way, landmarks such as the St. Theodosius Russian Orthodox Cathedral offer a look into the colorful history of the city.
� Admire the fine collections at the Cleveland Museum of Art, located in beautiful Wade Park � a site listed on the National Register of Historic Places.
� Float along the Cuyahoga River during a study cruise and explore Cleveland�s shoreline as it opens up to Lake Erie.
� Join a historian at the Western Reserve Historical Society for an insightful look at how millionaires and struggling immigrants built this dynamic city.
Activity Particulars
Walking up to two miles per day, use of public transportation.
Coordinated by University of Texas at Austin.
Cleveland is a city of half a million settled on the south shore of Lake Erie. In its industrial heyday, wealthy residents invested in arts and cultural institutions that today keep the city rich in cultural events. The downtown offers some striking turn-of-the-century architecture, and Cleveland is also home to the Rock �n� Roll Hall of Fame.
Comfortable hotel.
Meals and Lodgings
Hampton Inn Cleveland - Downtown
Cleveland, Ohio
3 nights
Hampton Inn Cleveland - Downtown
Contact info:
1460 E. Ninth Street
Cleveland, OH 44114 USA
phone: 216-241-6600
Smoking allowed:
Elevators available:
Additional nights prior:
Contact for details Please contact UT - Austin for details.
Check in time:
Additional nights after:
Contact for details Please contact UT - Austin for details.
Check out time:
Travel Details
Start of Program:
3:00 PM You will be staying at
Hampton Inn Cleveland - Downtown
that night.
End of Program:
11:00AM You will be staying at
Hampton Inn Cleveland - Downtown
the night before.
Required documents:
The Participant Information Form is required. The Health and Safety questionnaire and Release and Indemnification Agreement must be completed and returned to the Program Provider at least six weeks prior to the program.
Parking availability:
Self parking is available at the hotel for an additional charge. Road Scholar participants receive discounted parking from the hotel.
To Start of Program
Cleveland, Ohio
Nearest city or town:
Cleveland, Ohio
Nearest highway:
77, 71, Ohio Turnpike, 90
Nearest airport:
Cleveland Hopkins Airport
From End of Program
Cleveland, Ohio
Additional transportation information same as above
Travel Details
Cleveland Hopkins Airport
From Airport
Imagine That
phone: 866-956-8632
Advanced Reservations Required
Per Person/One Way:
approximately $45-$50, cost subject to change
Prices are subject to change.
Travel Time:
30-40 minutes depending on time of day
35-40 miles
see www.sendmearide.com for additional information
Cleveland Hopkins Airport
From Airport
Commercial Van/Shuttle
Ohio Connection
phone: 216-324-8999
Advanced Reservations Required
Per Person/One Way:
$52-$55, price subject to change
Prices are subject to change.
Travel Time:
30-40 minutes depending on time of day
35-40 miles
Cleveland Hopkins Airport
From Airport
Public Transportation
Rapid Transit
Per Person/One Way:
Prices are subject to change.
Travel Time:
25-30 minutes
11 miles
Take the Red Line to the Tower City stop. Exit Tower City and go up to street level. Exit through the main lobby and cross the terminal plaza. Head down Superior Avenue, through the Public Square, for 6 blocks. At the corner of Superior and 9th, the hotel will be on your left.
Cleveland Hopkins International
From Airport
Yellow Cab
Per Person/One Way:
Approximately $35 - up to 4 riders for one fare
Prices are subject to change.
Travel Time:
30 minutes
11 miles
Taxi's available outside the airport terminal.
Driving Directions
From Interstate Highways
From I-71, I-77, and I-90 Eastbound - Exit at East 9th St., north to Superior Ave. The hotel is on the left, at corner of E 9th and Superior. From I-90 Westbound - Follow Route 2 and exit at East 9th St., south on E 9th to Superior Ave. The hotel is on the right. GPS coordinates - Latitude: 41.5023592 Longitude: -81.6888917
From Pennsylvania and points east
Merge onto I-80 West via the ramp on the left (Portions toll) - (Crossing into Ohio). Merge onto I-480 West via Exit 187 toward Cleveland/Streetsboro. Keep right to take I-480 West via Exit 26A-B toward Cleveland. Merge onto I-77 North via Exit 20B toward Cleveland. Take the I-90 East exit on the left toward Erie PA/E 9th Street. Take Exit 163C toward E 9th Street. Turn slight right onto E 14th Street. Turn slight right onto Orange Ave/US-422/OH-8/OH-87. Continue to follow US-422 West/OH-8 West/OH-87 North. Turn right onto US-20/Superior Avenue East/US-322/US-6. Continue to follow Superior Ave East/US-322/US-6. The hotel will be on the right.
From the airport- CLE
TAKE INTERSTATE 71 NORTH, EXIT AT E 9TH ST, NORTH TO SUPERIOR AVE. HAMPTON INN DOWNTOWN CLEVELAND IS ON LEFT AT CORNER OF E 9TH AND SUPERIOR. Distance from Hotel: 13 mi. Drive Time: 20 min.
Elevation Note:
Cleveland has an elevation of 1100 feet.
The prices listed for commercial services and facilities that are not included in the program cost, such as airport shuttles or extra nights lodging, are subject to change without notice. Since Road Scholar cannot guarantee the accuracy of these prices, we strongly suggest contacting the companies directly for the most up-to-date information.
Daily Schedule
Day 1:
Arrival & Hotel Check-in, Registration & Orientation, Welcome & Introduction to Cleveland
(Thursday, August 29)
Orientation at 4:00 PM in hotel.
REGISTRATION & ORIENTATION: 4:00pm. in the hotel conference room. Pick up your Road Scholar arrival packet containing your name tag, up-to-date schedule, list of participants, maps, and other important information we will review. The on-site coordinator will greet you with a warm welcome, introduce everyone, and provide key staff contact names and phone numbers. We will review the up-to-date daily schedule, discuss responsibilities, safety guidelines, emergency procedures, and answer any questions you may have. If you arrive late, pick up your packet at the hotel front desk. Please be aware that program activities and scheduled times could change due to local circumstances. In the event of changes, we will alert you as quickly as possible. Thank you for your understanding. This City Highlights Weekend in Cleveland is a new Road Scholar "Flex" program. It is different from other programs with more opportunities for you to dine out and explore on your own. You will have the kind of expert-led learning opportunities you expect from Road Scholar, designed to showcase some of Cleveland�s most notable attractions. Several meals have been excluded from the program cost and you will have a large block of free time for personal independent exploration. Your arrival packet will include recommendations for free time activities and dining options. During free time, the Group Leader will be available to lead optional informal activities and dining out that you may join at your own cost if you wish. Please don't hesitate to ask if you have any questions. We hope you enjoy this new "Flex" program and the highlights of what's on in Cleveland this weekend.
Get to know your fellow participants in a welcome dinner at an intimate restaurant near the hotel.
Begin your stay with a night on the town as you catch a show in the largest performing arts district outside New York- Cleveland�s Playhouse Square. Watch a play or musical at one of nine theaters in the district, just a few blocks from your hotel. Or, the group may go to the House of Blues or another venue in the 4th Street entertainment district to hear live music.
Hampton Inn Cleveland - Downtown
Meals Included:
Day 2:
Highlights: Lake View Cemetery, Lunch Cruise on Lake Erie, Guided Bus Tour of Tremont and West Side Neighborhoods
(Friday, August 30)
Enjoy a full breakfast at your hotel.
FIELD TRIP: Discover the west side of the city on a visit to the West Side Market, which began operations in 1840. Your guide will share information about the market�s operations and how the character of the original building was preserved during recent renovations. Continue on to St. Theodosius Russian Orthodox Cathedral, modeled after churches in Moscow, which ministered to other ethnic groups who had not yet established their own ethnic churches in the early 20th century. Get special access to the inside of the Cathedral to admire its elaborate interior. See other points of interest in the Tremont neighborhood.
FIELD TRIP: Climb aboard the Nautica Queen to float from the Flats on the Cuyahoga River to Lake Erie and along the Cleveland shoreline. Get a new perspective on the city as you view it from the water, while hearing more about the city�s development and enjoying a delicious lunch. Learn about the origins of the city as an important port on Lake Erie as you travel under historic bridges on your journey to Lake Erie, where you�ll hear about the city�s growth as you see the downtown skyline. You�ll develop an appreciation of both the old and the new as you travel from the city�s original port areas to its modern downtown area, symbolized with shoreline icons such as the Rock & Roll Hall of Fame and the Greater Cleveland Aquarium.
FIELD TRIP: Learn more about the history of Cleveland at the Western Reserve Historical Society, located in the University Circle area of the city. An experienced historian will provide an overview of the city�s colorful history, and explain how the influence of both millionaires and struggling immigrants shaped the city. The rest of the afternoon and evening will be yours to explore on your own. You may want to visit attractions in the University Circle area, such as the Lakeview Cemetery, the Botanical Gardens, or Severance Hall, the home of the renowned Cleveland Orchestra. You can remain with the group leader at the Western Reserve Historical Society Museum (at your expense) to visit carefully preserved historic homes and see the Crawford Auto Aviation Collection. Or, you may want to use the city�s public transportation system to visit another area of interest- your group leader can help you choose a destination. There is something for everyone in this dynamic city.
Select a restaurant of your choosing as you explore the city on your own.
Hampton Inn Cleveland - Downtown
Meals Included:
Breakfast, Lunch
Day 3:
Cleveland Museum of Art, Free Afternoon and Evening to Explore on Your Own
(Saturday, August 31)
Enjoy a delicious buffet breakfast at the hotel.
FIELD TRIP: Travel by city bus to the Cleveland Museum of Art in University Circle. Museum staff members will tell you about the collections, new exhibition space, and the museum�s rich history. Docent-led exploration of the permanent collections will be followed by additional time on your own to peruse the museum's extensive galleries. The museum is located in the city�s University Circle area, an idyllic setting that is home to a large concentration of cultural, medical and educational institutions.
Box lunch at the newly renovated museum caf�.
The rest of your afternoon and evening are unscheduled, so you may explore some the city�s diverse attractions. You may choose to spend time with your group leader at the nearby Botanical Gardens, at your expense. There are many interesting choices available for your afternoon and evening. You will receive a list of nearby points of interest from which to choose. In the evening, you may want to hear the renowned Cleveland Symphony Orchestra, or find a sporting event, play, or musical performance to attend.
Dinner unscheduled to explore the many restaurant options in the city. You may join the group leader for a meal in the lively 4th Street entertainment district at your expense, if you wish.
Hampton Inn Cleveland - Downtown
Meals Included:
Breakfast, Lunch
Day 4:
Walking Tour of Public Square; Check-out and Departure
(Sunday, September 1)
Enjoy a delicious buffet breakfast at the hotel.
FIELD TRIP: Venture into the downtown area with on a guided walking tour of the Public Square and Mall, the result of an ambitious city planning scheme that combined commercial development with urban beautification efforts. Observe how commercial buildings, public transportation and open parkland are joined in this vibrant central district. Learn about important buildings from the city�s past, and how different architectural styles come together to form the city�s unique skyline. The program will conclude at the end of the walking tour, on the plaza of the Rock & Roll Hall of Fame and Museum. You can choose to explore the Hall of Fame (at your expense) or just walk a few blocks back to your hotel. The Hall of Fame museum documents the entire history of Rock and Roll and its precursors. Explore seven floors of exhibition space with 18 permanent exhibits highlighting the history behind the birth of rock and roll and spanning to today's popular artists. Peruse six special rotating exhibition areas, and six interactive listening exhibits, acknowledging the 500 Songs that Shaped Rock and Roll. View 126 minutes of film in five different theaters, including the Hall of Fame, a dramatic multi-media gallery on three giant screens to tell the story of Rock Hall inductees.
Meals Included:
Important information about your itinerary:
Every effort has been made to ensure the accuracy and completeness of the information featured on this website. Itineraries are based on our best information at this time. Circumstances beyond our control may require us to adjust itineraries or other details. We regret any inconvenience this may cause and appreciate your understanding. Information will be sent to you from your Program Provider approximately three weeks prior to the program start date. The prices listed for commercial services and facilities that are not included in the program cost, such as airport shuttles or extra nights lodging, are subject to change without notice. Since Road Scholar cannot guarantee the accuracy of these prices, we strongly suggest contacting the companies directly for the most up-to-date information.
Suggested Reading List
Cleveland's Downtown Architecture
Author: Shawn Patrick Hoefler
Description: Downtown Cleveland has many architectural landmarks that define this big, proud city on the lake. Most famous is Terminal Tower, the "grand dame" of Cleveland skyscrapers, which was the tallest office building outside of New York City from 1930 until 1967. Other notable high-rises such as the BP building, Key Tower, and the new Federal Court House with its distinctive lighted cornice also dominate the city's beautiful Lake Erie skyline. And then there are the details-the terra-cotta "starburst" motif on the exterior of the Standard Building, the extensive metal decorative work inside the gargoyle-encircled atrium of The Arcade, and the immense stained-glass dome of the Cleveland Trust Rotunda.
Cleveland: A Concise History
Author: Carol Miller and Robert Wheeler
Description: Excellent overview of Cleveland's history.
Cleveland: Then and Now
Author: John Grabowski and Diane Ewart Grabowski
Description: Cleveland Then and Now features fascinating archival photographs contrasted with specially commissioned, full-color images of the same scene today. This is a visual lesson in Cleveland history.
Conducting Business: Unveiling the Mystery Behind the Maestro
Author: Leonard Slatkin
Description: Conducting an orchestra is something that is seen as well as heard, but it is quite misunderstood when it comes to knowing what this person actually does for a living. This most mysterious of jobs is brought to life for the music lover as well as for the aspiring maestro in a new book by Leonard Slatkin. Drawing on his own experiences on and off the podium, Slatkin brings us into the world of the baton. He tells tales of some of the most fascinating people in the musical world, including Frank Sinatra, Leonard Bernstein, and John Williams. He takes the reader to the great concert halls and orchestras, sound stages in Hollywood, and opera pits around the globe. Mr. Slatkin recounts his controversial appearance at the Metropolitan Opera, his creation and direction of summer music festivals, and a shattering concert experience that took place four days following 9/11. Life in the recording studio and on the road as well as health issues confronting the conductor provide an insider's glimpse into the private world of public figures. Covering everything from learning how to read music to standing in front of an orchestra for the first time, what to wear, and how to deal with the press, Conducting Business is a unique look at a unique profession.
George Szell: A Life of Music
Author: Michael Charry
Description: This book is the first full biography of George Szell, one of the greatest orchestra and opera conductors of the twentieth century. From child prodigy pianist and composer to world-renowned conductor, Szell's career spanned seven decades. Michael Charry, a conductor who worked with Szell and interviewed him, his family, and his associates over several decades, constructs a lively and balanced portrait of Szell's life and work from his birth in 1897 in Budapest to his death in 1970 in Cleveland.
Showplace of America: Cleveland's Euclid Avenue, 1850-1910 (Ohio)
Author: Jan Cigliano
Description: Grand boulevards lined with elegant residences were found in many 19th-century American cities: none, however, was more exclusive than Cleveland's Euclid Avenue. Distinguished for its opulent architecture and the social caliber of its residents, Euclid Avenue was a very visible symbol of Cleveland's prosperity for over 50 years. A fascinating study of the area's development and how pollution, traffic and commercialism contributed to its decline.
The Encyclopedia of Cleveland History
Author: David Van Tassel and John Grabowski
Description: ech.case.edu
You can't find a better value than Road Scholar.
As a not-for-profit organization, we are dedicated to providing all-inclusive educational programs at great value. From lectures to gratuities to field trips to accommodations - the tuition you pay up front is all that you pay.
Specifically, this program includes:
3 nights accommodations
6 meals: 3 breakfasts, 2 lunches, 1 dinner
Expert-led lectures: 5
Expert-led lectures
Led by one or more of our world-class instructors, typically in a classroom setting, lectures come in the form of presentations, discussions or workshops and offer expert insight into your area of study.
Field trips: 5
Field trips
The world is your classroom, as you're on location with an instructor to pursue your educational theme firsthand.
Performances: 1
A performance can range from a night at the opera to a visit from a local performer at your hotel.
Plus these special experiences...
Admire masterpieces at the spectacular Cleveland Museum of Art and catch a show in one of the lovingly renovated Playhouse Square theater district.
With guides see Public Square, Lake View Cemetery, St. Theodosius Russian Orthodox Cathedral, and the Tremont neighborhood.
Enjoy a dining cruise, floating under historic bridges and experiencing the breathtaking view of Downtown Cleveland's ever-changing skyline.
Explore the city on your own, in this "flex" program, a significant amount of time of free time. Your group leader can give you lots of ideas!
View the Daily Schedule to see more
And included with all Road Scholar programs:
Learning led by expert instructors who are authorities in the field of study.
An experienced Group Leader attuned to the needs of Road Scholar participants.
Customary gratuities throughout the program that you would normally pay yourself.
The Road Scholar Travel Assistance Plan, providing 24-hour-a-day emergency assistance coverage.
© Road Scholar 2016
Call toll-free: 1-800-454-5768


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Vassiliki A. Boussiotis, Ph.D., M.D.
Professor of Medicine
Beth Israel Deaconess Medical Center
Beth Israel Deaconess Medical Center
Nrb 1030h
330 Brookline Ave
Boston MA 02215
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selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can
to make corrections and additions.
List All
Boussiotis VA. Cell-specific PD-L1 expression in DLBCL. Blood. 2015 Nov 5; 126(19):2171-2.
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Politikos I, Kim HT, Nikiforow S, Li L, Brown J, Antin JH, Cutler C, Ballen K, Ritz J, Boussiotis VA. IL-7 and SCF Levels Inversely Correlate with T Cell Reconstitution and Clinical Outcomes after Cord Blood Transplantation in Adults. PLoS One. 2015; 10(7):e0132564.
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Patsoukis N, Bardhan K, Chatterjee P, Sari D, Liu B, Bell LN, Karoly ED, Freeman GJ, Petkova V, Seth P, Li L, Boussiotis VA. PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation. Nat Commun. 2015; 6:6692.
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Satyanarayana G, Hammond SP, Broge TA, Mackenzie MR, Viscidi R, Politikos I, Koralnik IJ, Cutler CS, Ballen K, Boussiotis V, Marty FM, Tan CS. BK polyomavirus reactivation after reduced-intensity double umbilical cord blood cell transplantation. Transpl Immunol. 2015 Mar; 32(2):116-20.
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Boussiotis VA. Somatic mutations and immunotherapy outcome with CTLA-4 blockade in melanoma. N Engl J Med. 2014 Dec 4; 371(23):2230-2.
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Politikos I, Boussiotis VA. The role of the thymus in T-cell immune reconstitution after umbilical cord blood transplantation. Blood. 2014 Nov 20; 124(22):3201-11.
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Boussiotis VA, Chatterjee P, Li L. Biochemical signaling of PD-1 on T cells and its functional implications. Cancer J. 2014 Jul-Aug; 20(4):265-71.
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Nellore A, Liu B, Patsoukis N, Boussiotis VA, Li L. The cyclin dependent kinase inhibitor (R)-roscovitine mediates selective suppression of alloreactive human T cells but preserves pathogen-specific and leukemia-specific effectors. Clin Immunol. 2014 May-Jun; 152(1-2):48-57.
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Li L, Kim HT, Nellore A, Patsoukis N, Petkova V, McDonough S, Politikos I, Nikiforow S, Soiffer R, Antin JH, Ballen K, Cutler C, Ritz J, Boussiotis VA. Prostaglandin E2 promotes survival of naive UCB T cells via the Wnt/ß-catenin pathway and alters immune reconstitution after UCBT. Blood Cancer J. 2014; 4:e178.
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Patsoukis N, Li L, Sari D, Petkova V, Boussiotis VA. PD-1 increases PTEN phosphatase activity while decreasing PTEN protein stability by inhibiting casein kinase 2. Mol Cell Biol. 2013 Aug; 33(16):3091-8.
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Rosenblatt J, Avivi I, Vasir B, Uhl L, Munshi NC, Katz T, Dey BR, Somaiya P, Mills H, Campigotto F, Weller E, Joyce R, Levine JD, Tzachanis D, Richardson P, Laubach J, Raje N, Boussiotis V, Yuan YE, Bisharat L, Held V, Rowe J, Anderson K, Kufe D, Avigan D. Vaccination with dendritic cell/tumor fusions following autologous stem cell transplant induces immunologic and clinical responses in multiple myeloma patients. Clin Cancer Res. 2013 Jul 1; 19(13):3640-8.
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Li L, Boussiotis VA. The role of IL-17-producing Foxp3+ CD4+ T cells in inflammatory bowel disease and colon cancer. Clin Immunol. 2013 Aug; 148(2):246-53.
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Medraño-Fernandez I, Reyes R, Olazabal I, Rodriguez E, Sanchez-Madrid F, Boussiotis VA, Reche PA, Cabañas C, Lafuente EM. RIAM (Rap1-interacting adaptor molecule) regulates complement-dependent phagocytosis. Cell Mol Life Sci. 2013 Jul; 70(13):2395-410.
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Wynne JP, Wu J, Su W, Mor A, Patsoukis N, Boussiotis VA, Hubbard SR, Philips MR. Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector. J Cell Biol. 2012 Oct 15; 199(2):317-30.
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Patsoukis N, Sari D, Boussiotis VA. PD-1 inhibits T cell proliferation by upregulating p27 and p15 and suppressing Cdc25A. Cell Cycle. 2012 Dec 1; 11(23):4305-9.
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Li L, Patsoukis N, Petkova V, Boussiotis VA. Runx1 and Runx3 are involved in the generation and function of highly suppressive IL-17-producing T regulatory cells. PLoS One. 2012; 7(9):e45115.
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Patsoukis N, Brown J, Petkova V, Liu F, Li L, Boussiotis VA. Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation. Sci Signal. 2012 Jun 26; 5(230):ra46.
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Li L, Boussiotis VA. Molecular and functional heterogeneity of T regulatory cells. Clin Immunol. 2011 Dec; 141(3):244-52.
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Hernández-Varas P, Coló GP, Bartolomé RA, Paterson A, Medraño-Fernández I, Arellano-Sánchez N, Cabañas C, Sánchez-Mateos P, Lafuente EM, Boussiotis VA, Strömblad S, Teixidó J. Rap1-GTP-interacting adaptor molecule (RIAM) protein controls invasion and growth of melanoma cells. J Biol Chem. 2011 May 27; 286(21):18492-504.
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Li L, Kim Js, Boussiotis VA. Rap1A regulates generation of T regulatory cells via LFA-1-dependent and LFA-1-independent mechanisms. Cell Immunol. 2010; 266(1):7-13.
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Li L, Kim J, Boussiotis VA. IL-1ß-mediated signals preferentially drive conversion of regulatory T cells but not conventional T cells into IL-17-producing cells. J Immunol. 2010 Oct 1; 185(7):4148-53.
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Cutler C, Stevenson K, Kim HT, Brown J, McDonough S, Herrera M, Reynolds C, Liney D, Kao G, Ho V, Armand P, Koreth J, Alyea E, Dey BR, Attar E, Spitzer T, Boussiotis VA, Ritz J, Soiffer R, Antin JH, Ballen K. Double umbilical cord blood transplantation with reduced intensity conditioning and sirolimus-based GVHD prophylaxis. Bone Marrow Transplant. 2011 May; 46(5):659-67.
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Rosenblatt J, Wu Z, Vasir B, Zarwan C, Stone R, Mills H, Friedman T, Konstantinopoulos PA, Spentzos D, Ghebremichael M, Stevenson K, Neuberg D, Levine JD, Joyce R, Tzachanis D, Boussiotis V, Kufe D, Avigan D. Generation of tumor-specific T lymphocytes using dendritic cell/tumor fusions and anti-CD3/CD28. J Immunother. 2010 Feb-Mar; 33(2):155-66.
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Brown JA, Stevenson K, Kim HT, Cutler C, Ballen K, McDonough S, Reynolds C, Herrera M, Liney D, Ho V, Kao G, Armand P, Koreth J, Alyea E, McAfee S, Attar E, Dey B, Spitzer T, Soiffer R, Ritz J, Antin JH, Boussiotis VA. Clearance of CMV viremia and survival after double umbilical cord blood transplantation in adults depends on reconstitution of thymopoiesis. Blood. 2010 May 20; 115(20):4111-9.
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Rosenblatt J, Bissonnette A, Ahmad R, Wu Z, Vasir B, Stevenson K, Zarwan C, Keefe W, Glotzbecker B, Mills H, Joyce R, Levine JD, Tzachanis D, Boussiotis V, Kufe D, Avigan D. Immunomodulatory effects of vitamin D: implications for GVHD. Bone Marrow Transplant. 2010 Sep; 45(9):1463-8.
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Patsoukis N, Lafuente EM, Meraner P, Kim Js, Dombkowski D, Li L, Boussiotis VA. RIAM regulates the cytoskeletal distribution and activation of PLC-gamma1 in T cells. Sci Signal. 2009; 2(99):ra79.
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Li L, Wang H, Kim Js, Pihan G, Boussiotis V. The cyclin dependent kinase inhibitor (R)-roscovitine prevents alloreactive T cell clonal expansion and protects against acute GvHD. Cell Cycle. 2009 Jun 1; 8(11):1794 - 1802.
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Tzachanis D, Boussiotis VA. Tob, a member of the APRO family, regulates immunological quiescence and tumor suppression. Cell Cycle. 2009 Apr 1; 8(7):1019-25.
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Zhou D, Medoff BD, Chen L, Li L, Zhang XF, Praskova M, Liu M, Landry A, Blumberg RS, Boussiotis VA, Xavier R, Avruch J. The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20321-6.
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Cardoso BA, Martins LR, Santos CI, Nadler LM, Boussiotis VA, Cardoso AA, Barata JT. Interleukin-4 stimulates proliferation and growth of T-cell acute lymphoblastic leukemia cells by activating mTOR signaling. Leukemia. 2009 Jan; 23(1):206-8.
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Watanabe N, Bodin L, Pandey M, Krause M, Coughlin S, Boussiotis VA, Ginsberg MH, Shattil SJ. Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3. J Cell Biol. 2008 Jun 30; 181(7):1211-22.
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Ge X, Brown J, Sykes M, Boussiotis VA. CD134-allodepletion allows selective elimination of alloreactive human T cells without loss of virus-specific and leukemia-specific effectors. Biol Blood Marrow Transplant. 2008 May; 14(5):518-30.
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Friedberg J, Jacobsen E, Neuberg D, Kutok J, Munoz O, Boussiotis V, Reynolds H, Fisher D, Szot A, Van Den Abbeele A, Freedman A. Targeting the follicular lymphoma microenvironment through blockade of TNFalpha with etanercept. Leuk Lymphoma. 2008 May; 49(5):902-9.
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Brown JA, Boussiotis VA. Umbilical cord blood transplantation: basic biology and clinical challenges to immune reconstitution. Clin Immunol. 2008 Jun; 127(3):286-97.
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Muzio M, Apollonio B, Scielzo C, Frenquelli M, Vandoni I, Boussiotis V, Caligaris-Cappio F, Ghia P. Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy. Blood. 2008 Jul 1; 112(1):188-95.
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Li L, Boussiotis VA. Control and regulation of peripheral tolerance in allergic inflammatory disease: therapeutic consequences. Chem Immunol Allergy. 2008; 94:178-88.
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O'Shaughnessy MJ, Chen ZM, Gramaglia I, Taylor PA, Panoskaltsis-Mortari A, Vogtenhuber C, Palmer E, Grader-Beck T, Boussiotis VA, Blazar BR. Elevation of intracellular cyclic AMP in alloreactive CD4(+) T Cells induces alloantigen-specific tolerance that can prevent GVHD lethality in vivo. Biol Blood Marrow Transplant. 2007 May; 13(5):530-42.
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Lafuente EM, Iwamoto Y, Carman CV, van Puijenbroek AA, Constantine E, Li L, Boussiotis VA. Active Rap1, a small GTPase that induces malignant transformation of hematopoietic progenitors, localizes in the nucleus and regulates protein expression. Leuk Lymphoma. 2007 May; 48(5):987-1002.
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Tzachanis D, Li L, Lafuente EM, Berezovskaya A, Freeman GJ, Boussiotis VA. Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes. Blood. 2007 Apr 1; 109(7):2944-52.
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Li L, Iwamoto Y, Berezovskaya A, Boussiotis VA. A pathway regulated by cell cycle inhibitor p27Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance. Nat Immunol. 2006 Nov; 7(11):1157-65.
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Han J, Lim CJ, Watanabe N, Soriani A, Ratnikov B, Calderwood DA, Puzon-McLaughlin W, Lafuente EM, Boussiotis VA, Shattil SJ, Ginsberg MH. Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3. Curr Biol. 2006 Sep 19; 16(18):1796-806.
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Appleman LJ, Chernova I, Li L, Boussiotis VA. CD28 costimulation mediates transcription of SKP2 and CKS1, the substrate recognition components of SCFSkp2 ubiquitin ligase that leads p27kip1 to degradation. Cell Cycle. 2006 Sep; 5(18):2123-9.
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Li L, Boussiotis VA. Physiologic regulation of central and peripheral T cell tolerance: lessons for therapeutic applications. J Mol Med (Berl). 2006 Nov; 84(11):887-99.
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Lafuente E, Boussiotis VA. Rap1 regulation of RIAM and cell adhesion. Methods Enzymol. 2006; 407:345-58.
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Li L, Greenwald RJ, Lafuente EM, Tzachanis D, Berezovskaya A, Freeman GJ, Sharpe AH, Boussiotis VA. Rap1-GTP is a negative regulator of Th cell function and promotes the generation of CD4+CD103+ regulatory T cells in vivo. J Immunol. 2005 Sep 1; 175(5):3133-9.
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Li L, Godfrey WR, Porter SB, Ge Y, June CH, Blazar BR, Boussiotis VA. CD4+CD25+ regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy. Blood. 2005 Nov 1; 106(9):3068-73.
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Barata JT, Cardoso AA, Boussiotis VA. Interleukin-7 in T-cell acute lymphoblastic leukemia: an extrinsic factor supporting leukemogenesis? Leuk Lymphoma. 2005 Apr; 46(4):483-95.
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Appleman LJ, Boussiotis V. In vitro models of human T cell anergy. Curr Protoc Immunol. 2005 Mar; Chapter 7:Unit 7.36.
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Barata JT, Keenan TD, Silva A, Nadler LM, Boussiotis VA, Cardoso AA. Common gamma chain-signaling cytokines promote proliferation of T-cell acute lymphoblastic leukemia. Haematologica. 2004 Dec; 89(12):1459-67.
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Vassilakopoulos TP, Angelopoulou MK, Constantinou N, Karmiris T, Repoussis P, Roussou P, Siakantaris MP, Korkolopoulou P, Kyrtsonis MC, Kokoris SI, Dimopoulou MN, Variamis E, Viniou NA, Konstantopoulos K, Dimitriadou EM, Androulaki A, Patsouris E, Doussis-Anagnostopoulou IA, Panayiotidis P, Boussiotis VA, Kittas C, Pangalis GA. Development and validation of a clinical prediction rule for bone marrow involvement in patients with Hodgkin lymphoma. Blood. 2005 Mar 1; 105(5):1875-80.
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Tzachanis D, Lafuente EM, Li L, Boussiotis VA. Intrinsic and extrinsic regulation of T lymphocyte quiescence. Leuk Lymphoma. 2004 Oct; 45(10):1959-67.
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Krause M, Leslie JD, Stewart M, Lafuente EM, Valderrama F, Jagannathan R, Strasser GA, Rubinson DA, Liu H, Way M, Yaffe MB, Boussiotis VA, Gertler FB. Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics. Dev Cell. 2004 Oct; 7(4):571-83.
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Lafuente EM, van Puijenbroek AA, Krause M, Carman CV, Freeman GJ, Berezovskaya A, Constantine E, Springer TA, Gertler FB, Boussiotis VA. RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. Dev Cell. 2004 Oct; 7(4):585-95.
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Barata JT, Silva A, Brandao JG, Nadler LM, Cardoso AA, Boussiotis VA. Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells. J Exp Med. 2004 Sep 6; 200(5):659-69.
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Vassilakopoulos TP, Angelopoulou MK, Siakantaris MP, Kontopidou FN, Dimopoulou MN, Kokoris SI, Kyrtsonis MC, Tsaftaridis P, Karkantaris C, Anargyrou K, Boutsis DE, Variamis E, Michalopoulos T, Boussiotis VA, Panayiotidis P, Papavassiliou C, Pangalis GA. Combination chemotherapy plus low-dose involved-field radiotherapy for early clinical stage Hodgkin's lymphoma. Int J Radiat Oncol Biol Phys. 2004 Jul 1; 59(3):765-81.
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Barata JT, Boussiotis VA, Yunes JA, Ferrando AA, Moreau LA, Veiga JP, Sallan SE, Look AT, Nadler LM, Cardoso AA. IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL. Blood. 2004 Mar 1; 103(5):1891-900.
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Tzachanis D, Appleman LJ, Van Puijenbroek AA, Berezovskaya A, Nadler LM, Boussiotis VA. Differential localization and function of ADP-ribosylation factor-6 in anergic human T cells: a potential marker for their identification. J Immunol. 2003 Aug 15; 171(4):1691-6.
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Appleman LJ, Boussiotis VA. T cell anergy and costimulation. Immunol Rev. 2003 Apr; 192:161-80.
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Grader-Beck T, van Puijenbroek AA, Nadler LM, Boussiotis VA. cAMP inhibits both Ras and Rap1 activation in primary human T lymphocytes, but only Ras inhibition correlates with blockade of cell cycle progression. Blood. 2003 Feb 1; 101(3):998-1006.
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Appleman LJ, Tzachanis D, Grader-Beck T, Van Puijenbroek AA, Boussiotis VA. Induction of immunologic tolerance for allogeneic hematopoietic cell transplantation. Leuk Lymphoma. 2002 Jun; 43(6):1159-67.
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Delgado JC, Tsai EY, Thim S, Baena A, Boussiotis VA, Reynes JM, Sath S, Grosjean P, Yunis EJ, Goldfeld AE. Antigen-specific and persistent tuberculin anergy in a cohort of pulmonary tuberculosis patients from rural Cambodia. Proc Natl Acad Sci U S A. 2002 May 28; 99(11):7576-81.
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Appleman LJ, van Puijenbroek AA, Shu KM, Nadler LM, Boussiotis VA. CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells. J Immunol. 2002 Mar 15; 168(6):2729-36.
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Tzachanis D, Berezovskaya A, Nadler LM, Boussiotis VA. Blockade of B7/CD28 in mixed lymphocyte reaction cultures results in the generation of alternatively activated macrophages, which suppress T-cell responses. Blood. 2002 Feb 15; 99(4):1465-73.
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Greenwald RJ, Oosterwegel MA, van der Woude D, Kubal A, Mandelbrot DA, Boussiotis VA, Sharpe AH. CTLA-4 regulates cell cycle progression during a primary immune response. Eur J Immunol. 2002 Feb; 32(2):366-73.
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Tzachanis D, Freeman GJ, Hirano N, van Puijenbroek AA, Delfs MW, Berezovskaya A, Nadler LM, Boussiotis VA. Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells. Nat Immunol. 2001 Dec; 2(12):1174-82.
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Vassilakopoulos TP, Angelopoulou MK, Siakantaris MP, Kontopidou FN, Dimopoulou MN, Barbounis A, Grigorakis V, Karkantaris C, Anargyrou K, Chatziioannou M, Rombos J, Boussiotis VA, Vaiopoulos G, Kittas C, Pangalis GA. Prognostic factors in advanced stage Hodgkin's lymphoma: the significance of the number of involved anatomic sites. Eur J Haematol. 2001 Nov-Dec; 67(5-6):279-88.
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Kyrtsonis MC, Vassilakopoulos TP, Angelopoulou MK, Siakantaris P, Kontopidou FN, Dimopoulou MN, Boussiotis V, Gribabis A, Konstantopoulos K, Vaiopoulos GA, Fessas P, Kittas C, Pangalis GA. Waldenström's macroglobulinemia: clinical course and prognostic factors in 60 patients. Experience from a single hematology unit. Ann Hematol. 2001 Dec; 80(12):722-7.
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Barata JT, Cardoso AA, Nadler LM, Boussiotis VA. Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by down-regulating the cyclin-dependent kinase inhibitor p27(kip1). Blood. 2001 Sep 1; 98(5):1524-31.
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Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long AJ, Brown JA, Nunes R, Greenfield EA, Bourque K, Boussiotis VA, Carter LL, Carreno BM, Malenkovich N, Nishimura H, Okazaki T, Honjo T, Sharpe AH, Freeman GJ. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol. 2001 Mar; 2(3):261-8.
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Greenwald RJ, Boussiotis VA, Lorsbach RB, Abbas AK, Sharpe AH. CTLA-4 regulates induction of anergy in vivo. Immunity. 2001 Feb; 14(2):145-55.
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Boussiotis VA, Chen ZM, Zeller JC, Murphy WJ, Berezovskaya A, Narula S, Roncarolo MG, Blazar BR. Altered T-cell receptor + CD28-mediated signaling and blocked cell cycle progression in interleukin 10 and transforming growth factor-beta-treated alloreactive T cells that do not induce graft-versus-host disease. Blood. 2001 Jan 15; 97(2):565-71.
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Appleman LJ, Tzachanis D, Grader-Beck T, van Puijenbroek AA, Boussiotis VA. Helper T cell anergy: from biochemistry to cancer pathophysiology and therapeutics. J Mol Med (Berl). 2001; 78(12):673-83.
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McAdam AJ, Chang TT, Lumelsky AE, Greenfield EA, Boussiotis VA, Duke-Cohan JS, Chernova T, Malenkovich N, Jabs C, Kuchroo VK, Ling V, Collins M, Sharpe AH, Freeman GJ. Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells. J Immunol. 2000 Nov 1; 165(9):5035-40.
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Boussiotis VA, Tsai EY, Yunis EJ, Thim S, Delgado JC, Dascher CC, Berezovskaya A, Rousset D, Reynes JM, Goldfeld AE. IL-10-producing T cells suppress immune responses in anergic tuberculosis patients. J Clin Invest. 2000 May; 105(9):1317-25.
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Boussiotis VA, Freeman GJ, Taylor PA, Berezovskaya A, Grass I, Blazar BR, Nadler LM. p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes. Nat Med. 2000 Mar; 6(3):290-7.
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Angelopoulou MK, Vassilakopoulos TP, Siakantaris MP, Kontopidou FN, Boussiotis VA, Papavassiliou C, Kittas C, Pangalis GA. EBVD combination chemotherapy plus low dose involved field radiation is a highly effective treatment modality for early stage Hodgkin's disease. Leuk Lymphoma. 2000 Mar; 37(1-2):131-43.
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Appleman LJ, Berezovskaya A, Grass I, Boussiotis VA. CD28 costimulation mediates T cell expansion via IL-2-independent and IL-2-dependent regulation of cell cycle progression. J Immunol. 2000 Jan 1; 164(1):144-51.
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Guinan EC, Boussiotis VA, Neuberg D, Brennan LL, Hirano N, Nadler LM, Gribben JG. Transplantation of anergic histoincompatible bone marrow allografts. N Engl J Med. 1999 Jun 3; 340(22):1704-14.
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Boussiotis VA, Freedman AS, Nadler LM. Bone marrow transplantation for low-grade lymphoma and chronic lymphocytic leukemia. Semin Hematol. 1999 Apr; 36(2):209-16.
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Boussiotis VA, Freeman GJ, Gribben JG, Hayes DF, Nadler LM. No evidence for MUC 1-induced apoptosis. Nat Med. 1998 Oct; 4(10):1093.
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Freeman GJ, Cardoso AA, Boussiotis VA, Anumanthan A, Groves RW, Kupper TS, Clark EA, Nadler LM. The BB1 monoclonal antibody recognizes both cell surface CD74 (MHC class II-associated invariant chain) as well as B7-1 (CD80), resolving the question regarding a third CD28/CTLA-4 counterreceptor. J Immunol. 1998 Sep 15; 161(6):2708-15.
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Ghia P, Boussiotis VA, Schultze JL, Cardoso AA, Dorfman DM, Gribben JG, Freedman AS, Nadler LM. Unbalanced expression of bcl-2 family proteins in follicular lymphoma: contribution of CD40 signaling in promoting survival. Blood. 1998 Jan 1; 91(1):244-51.
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Boussiotis VA, Freeman GJ, Berezovskaya A, Barber DL, Nadler LM. Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1. Science. 1997 Oct 3; 278(5335):124-8.
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Boussiotis VA, Lee BJ, Freeman GJ, Gribben JG, Nadler LM. Induction of T cell clonal anergy results in resistance, whereas CD28-mediated costimulation primes for susceptibility to Fas- and Bax-mediated programmed cell death. J Immunol. 1997 Oct 1; 159(7):3156-67.
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Cardoso AA, Seamon MJ, Afonso HM, Ghia P, Boussiotis VA, Freeman GJ, Gribben JG, Sallan SE, Nadler LM. Ex vivo generation of human anti-pre-B leukemia-specific autologous cytolytic T cells. Blood. 1997 Jul 15; 90(2):549-61.
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Gimmi CD, Morrison BW, Mainprice BA, Gribben JG, Boussiotis VA, Freeman GJ, Park SY, Watanabe M, Gong J, Hayes DF, Kufe DW, Nadler LM. Breast cancer-associated antigen, DF3/MUC1, induces apoptosis of activated human T cells. Nat Med. 1996 Dec; 2(12):1367-70.
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Hall KT, Boumsell L, Schultze JL, Boussiotis VA, Dorfman DM, Cardoso AA, Bensussan A, Nadler LM, Freeman GJ. Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11780-5.
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Boussiotis VA, Freeman GJ, Gribben JG, Nadler LM. The role of B7-1/B7-2:CD28/CLTA-4 pathways in the prevention of anergy, induction of productive immunity and down-regulation of the immune response. Immunol Rev. 1996 Oct; 153:5-26.
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Boussiotis VA, Pardo NA, Collins H, Houghton A, Ritz J, Nadler LM, Soiffer RJ. R24 anti-GD3 ganglioside antibody can induce costimulation and prevent the induction of alloantigen-specific T cell clonal anergy. Eur J Immunol. 1996 Sep; 26(9):2149-54.
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Boussiotis VA, Barber DL, Lee BJ, Gribben JG, Freeman GJ, Nadler LM. Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation. J Exp Med. 1996 Aug 1; 184(2):365-76.
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Cardoso AA, Schultze JL, Boussiotis VA, Freeman GJ, Seamon MJ, Laszlo S, Billet A, Sallan SE, Gribben JG, Nadler LM. Pre-B acute lymphoblastic leukemia cells may induce T-cell anergy to alloantigen. Blood. 1996 Jul 1; 88(1):41-8.
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Gribben JG, Guinan EC, Boussiotis VA, Ke XY, Linsley L, Sieff C, Gray GS, Freeman GJ, Nadler LM. Complete blockade of B7 family-mediated costimulation is necessary to induce human alloantigen-specific anergy: a method to ameliorate graft-versus-host disease and extend the donor pool. Blood. 1996 Jun 1; 87(11):4887-93.
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Angelopoulou MA, Poziopoulos C, Boussiotis VA, Kontopidou F, Pangalis GA. Fludarabine monophosphate in refractory B-chronic lymphocytic leukemia: maintenance may be significant to sustain response. Leuk Lymphoma. 1996 Apr; 21(3-4):321-4.
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Souliotis VL, Valavanis C, Boussiotis VA, Pangalis GA, Kyrtopoulos SA. Comparative study of the formation and repair of O6-methylguanine in humans and rodents treated with dacarbazine. Carcinogenesis. 1996 Apr; 17(4):725-32.
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Freeman GJ, Boussiotis VA, Anumanthan A, Bernstein GM, Ke XY, Rennert PD, Gray GS, Gribben JG, Nadler LM. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4. Immunity. 1995 May; 2(5):523-32.
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Boussiotis VA, Freeman GJ, Gribben JG, Nadler LM. The critical role of CD28 signalling in the prevention of human T-cell anergy. Res Immunol. 1995 Mar-Apr; 146(3):140-9.
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Gribben JG, Freeman GJ, Boussiotis VA, Rennert P, Jellis CL, Greenfield E, Barber M, Restivo VA, Ke X, Gray GS, et al. CTLA4 mediates antigen-specific apoptosis of human T cells. Proc Natl Acad Sci U S A. 1995 Jan 31; 92(3):811-5.
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Guinan EC, Gribben JG, Boussiotis VA, Freeman GJ, Nadler LM. Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity. Blood. 1994 Nov 15; 84(10):3261-82.
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Boussiotis VA, Barber DL, Nakarai T, Freeman GJ, Gribben JG, Bernstein GM, D'Andrea AD, Ritz J, Nadler LM. Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor. Science. 1994 Nov 11; 266(5187):1039-42.
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Boussiotis VA, Freeman GJ, Griffin JD, Gray GS, Gribben JG, Nadler LM. CD2 is involved in maintenance and reversal of human alloantigen-specific clonal anergy. J Exp Med. 1994 Nov 1; 180(5):1665-73.
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Boussiotis VA, Gribben JG, Freeman GJ, Nadler LM. Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance. Curr Opin Immunol. 1994 Oct; 6(5):797-807.
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Souliotis VL, Valavanis C, Boussiotis VA, Pangalis GA, Kyrtopoulos SA. Comparative dosimetry of O6-methylguanine in humans and rodents treated with procarbazine. Carcinogenesis. 1994 Aug; 15(8):1675-80.
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Kourtis AP, Boussiotis VA, Lymberi P, Pangalis GA. Increased natural antibody activity in sera of patients with malignant non-Hodgkin's lymphomas containing paraproteins. Am J Hematol. 1994 Aug; 46(4):283-8.
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Boussiotis VA, Nadler LM, Strominger JL, Goldfeld AE. Tumor necrosis factor alpha is an autocrine growth factor for normal human B cells. Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15):7007-11.
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Korkolopoulou P, Pangalis GA, Patsouris E, Boussiotis VA, Kittas C. B-cell lymphoma of large multilobated type: an immunohistochemical study of 8 cases and review of the literature. Leuk Lymphoma. 1994 Mar; 13(1-2):151-9.
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Gribabis DA, Panayiotidis P, Boussiotis VA, Hannoun C, Pangalis GA. Influenza virus vaccine in B-cell chronic lymphocytic leukaemia patients. Acta Haematol. 1994; 91(3):115-8.
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Salles G, Zain M, Jiang WM, Boussiotis VA, Shipp MA. Alternatively spliced CD44 transcripts in diffuse large-cell lymphomas: characterization and comparison with normal activated B cells and epithelial malignancies. Blood. 1993 Dec 15; 82(12):3539-47.
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Pangalis GA, Vassilakopoulos TP, Boussiotis VA, Fessas P. Clinical approach to lymphadenopathy. Semin Oncol. 1993 Dec; 20(6):570-82.
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Boussiotis VA, Freeman GJ, Gribben JG, Daley J, Gray G, Nadler LM. Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation. Proc Natl Acad Sci U S A. 1993 Dec 1; 90(23):11059-63.
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Freeman GJ, Gribben JG, Boussiotis VA, Ng JW, Restivo VA, Lombard LA, Gray GS, Nadler LM. Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation. Science. 1993 Nov 5; 262(5135):909-11.
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Boussiotis VA, Freeman GJ, Gray G, Gribben J, Nadler LM. B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance. J Exp Med. 1993 Nov 1; 178(5):1753-63.
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Pangalis GA, Boussiotis VA, Kittas C. Malignant disorders of small lymphocytes. Small lymphocytic lymphoma, lymphoplasmacytic lymphoma, and chronic lymphocytic leukemia: their clinical and laboratory relationship. Am J Clin Pathol. 1993 Apr; 99(4):402-8.
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Kyrtopoulos SA, Souliotis VL, Valavanis C, Boussiotis VA, Pangalis GA. Accumulation of O6-methylguanine in human DNA after therapeutic exposure to methylating agents and its relationship with biological effects. Environ Health Perspect. 1993 Mar; 99:143-7.
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Goldfeld AE, Flemington EK, Boussiotis VA, Theodos CM, Titus RG, Strominger JL, Speck SH. Transcription of the tumor necrosis factor alpha gene is rapidly induced by anti-immunoglobulin and blocked by cyclosporin A and FK506 in human B cells. Proc Natl Acad Sci U S A. 1992 Dec 15; 89(24):12198-201.
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Boussiotis VA, Pangalis GA. Interferon alfa-2b therapy in untreated early stage, B-chronic lymphocytic leukaemia patients: one-year follow-up. Br J Haematol. 1991 Oct; 79 Suppl 1:30-3.
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Pangalis GA, Boussiotis VA, Kittas C, Panayiotidis PG, Loukopoulos D, Fessas P, Mitsoulis-Mentzikoff C. Hairy cell leukemia: splenectomy after alpha 2b-interferon therapy. Blood. 1991 Sep 1; 78(5):1385.
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Souliotis VL, Boussiotis VA, Pangalis GA, Kyrtopoulos SA. In vivo formation and repair of O6-methylguanine in human leukocyte DNA after intravenous exposure to dacarbazine. Carcinogenesis. 1991 Feb; 12(2):285-8.
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Yataganas X, Meletis J, Plata E, Viniou N, Deligiannis F, Tsekoura C, Voscaridou E, Boussiotis V, Rombos J, Vayopoulos G, et al. alpha Interferon treatment of essential thrombocythaemia and other myeloproliferative disorders with excessive thrombocytosis. Eur J Cancer. 1991; 27 Suppl 4:S69-71.
View in:
Boussiotis VA, Pangalis GA. Interferon alfa-2b in stage A untreated B-chronic lymphocytic leukaemia patients. Eur J Cancer. 1991; 27 Suppl 4:S78-9.
View in:
Souliotis VL, Kaila S, Boussiotis VA, Pangalis GA, Kyrtopoulos SA. Accumulation of O6-methylguanine in human blood leukocyte DNA during exposure to procarbazine and its relationships with dose and repair. Cancer Res. 1990 May 1; 50(9):2759-64.
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Boussiotis VA, Pangalis GA. Randomized clinical trial with alpha 2b-interferon in 26 stage A untreated B-chronic lymphocytic leukemia patients. Nouv Rev Fr Hematol. 1988; 30(5-6):471-3.
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Pangalis GA, Boussiotis VA, Kittas C. B-chronic lymphocytic leukemia. Disease progression in 150 untreated stage A and B patients as predicted by bone marrow pattern. Nouv Rev Fr Hematol. 1988; 30(5-6):373-5.
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Locally Made Monday - Sweets So Geek
By ANDREW LOGSDON | firstname.lastname@example.com
Imagine eating a caramel-filled chocolate Han Solo called a 'Han Rolo.'
Fort Wayne-based Sweets So Geek is making chocolates and other goods with a sci-fi or comics theme.
It's this week's Locally Made Monday report.
Chad and Heather Seewald started making their goodies out of a love for geek culture.
Through the internet and local sales, they've expanded it from a hobby to a national phenomenon.
"We got started as a hobby. We created a Han Solo in carbonite in chocolate filled with caramel, we called him a Han Rolo, and we just gave it away as a Christmas present to friends and family," Chad Seewald says.
Little did they know three years ago that their gifts would be the idea they've been looking for.
"And gave it to a friend who owns intergalactic toys here in town and he loved it. Thought we should start selling them, so we did," Seewald says.
The Seewalds started an Etsy shop online two years ago- selling the star-wars themed chocolates- before expanding to other geek-related candies- like brain truffles, cookies and cakes.
"The biggest seller we have is the bacon bite, which is bacon, peanuts and chocolate. Nothing goes better than bacon with anything," Seewald says.
In all- twenty-two different types of chocolates- including their non-geek line- Sweets So Chic.
"We are mainly an internet company. So we can ship nationwide. We have an Etsy website, our own website, sweetssogeek.com. Locally, we partner with a lot of vendors. Clem's collectables is the main one right now," Seewald says.
And soon, local comics and game stores.
It's all homemade inside their kitchen in downtown Fort Wayne, and Seewald says it's a local event.
"We like to partner with mainly local companies if at all possible, and even source a lot of our items locally. We find it's super important. We're small scale, and all the help we get is local," Seewald says.
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text:
Jack Reacher
Jack Reacher (Tom Cruise) has a vigilante approach to justice. So his initial investigation into five murders committed by a former military sniper is a bit of a witch-hunt until he discovers some deeper, unanswered questions about the crimes.
|MPAA Rating
|PG-13 for violence, language and some drug material.
|Theatrical Release
|December 20, 2012
|Christopher McQuarrie
|Tom Cruise, Rosamund Pike, Robert Duvall, Jai Courtney
|Run Time
|2012 Paramount Pictures
|Official Movie Website
Full Review
Why did we give Jack Reacher an overall grade of C-? Read our full movie review for parents.
Content Details
Why is Jack Reacher rated PG-13?
Jack Reacher has a grade of B- for sex, D+ for language and D+ for violence. Find out why...
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Unfortunately we have no news to report on this title at this time.
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Jack Reacher is available on home video. Check this page for full information, along with alternative video titles.
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text:
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text:
Previous Issue
Cover Story
"The day I knew I was pregnant again, I wanted to end my life. I didn't want to go through the pain of burying my baby."
How does God speak to get our attention? Whose voice does He use?
In a Child Survival Program in Kisumu, Kenya, a simple solution of salts and sugars contains the key to transformation.
In fiscal year 2015, 81.8% of Compassion's expenses went directly to program activities helping children in our programs. This is one of the highest percentages for a child sponsorship organization.
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"I can be a better mother to my children as I learn many new things at the CSP." — Flora, CSP mom in Indonesia
Compassion has been a trusted charity since 1952.
Numerous financial accountability groups and accrediting agencies have recognized Compassion for superior integrity.
"Partnering with God to raise up a leader in El Salvador
has been one of my greatest joys." — Brianne
Your donation to the Where Most Needed fund will help Compassion better serve children in extreme poverty.
"Thanks for fixing my heart!" — Fatao, a Compassion-assisted child from Burkina Faso
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Charity Navigator has awarded Compassion its highest rating for 14 consecutive years, placing Compassion in the top 1 percent of all charities. Give your tax-deductible gift today.


text:
Diversified Telecommunication Services
Company Overview of WIND Hellas Telecommunications S.A.
Company Overview
66 Kifissias Avenue
Athens, 15125
Founded in 1992
1,475 Employees
30 210 61 58 000
30 211 98 91 791
Key Executives for WIND Hellas Telecommunications S.A.
WIND Hellas Telecommunications S.A. Key Developments
Wind Hellas announced the start of pre-sales 20 March for the Samsung phones. Official sales will start 17 April. The operator will offer the phones in a choice of white, black, gold or blue, at reduced prices with service contracts.
Wind Hellas announced the launch of a new subscription video-on-demand service called iLoveTV. The streaming service developed with Attica Publications offers 42 popular American, Turkish, Latin American and European series, such as Suleiman the Magnificent, the Borgias, Spartacus, Magic City, Hemlock Grove and Gomorrah to stream on a computer, TV or tablet without ads. Wind is offering one month free to its customers who sign up by 07 October and then a 50% discount on the subscription for a price of EUR 4.99 per month.
WIND Hellas Telecommunications S.A. is seeking acquisition opportunities. WIND Hellas is looking to raise cash to fuel future growth. It could also use the money for the upcoming spectrum auction or for acquisitions.
Similar Private Companies By Industry
|Company Name
|UNITEL Hellas S.A.
|On Telecoms S.A.
|Voicenet S.A.
|KB Impuls Hellas S.A.
|Cosmoline Telecommunication Services S.A.
Recent Private Companies Transactions
|No transactions available in the past 12 months.
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To contact WIND Hellas Telecommunications S.A., please visit www.wind.com.gr. Company data is provided by Capital IQ. Please use this form to report any data issues.
Our data partners will research the update request and update the information on this page if necessary. Research and follow-up could take several weeks. If you have questions, you can contact them at firstname.lastname@example.com.


text: It is easy to say that patients are at the center of healthcare, but a challenge healthcare leaders face centers on the question of responsibility for the patients' care. Some providers are evaluating the patients' role, committing resources to help educate them as to their central place in healthcare. Others are still struggling to understand the impact of patient-centered approaches.


text:
What does BCHCP stand for?
What does BCHCP mean? This page is about the various possible meanings of the acronym, abbreviation, shorthand or slang term: BCHCP.
We've found a total of 4 definitions for BCHCP:
Filter by: Sort by:PopularityAlphabeticallyCategory
Backus Community Hospital Cancer Program
B C Healthy Connections Project
British Columbia Healthy Connections Project
Balcones Canyonlands Habitat Conservation Plan
Still can't find the acronym definition you were looking for? Use our Power Search technology to look for more unique definitions from across the web!
"BCHCP." Abbreviations.com. STANDS4 LLC, 2016. Web. 9 Feb. 2016. <http://www.abbreviations.com/BCHCP>.


text: This is a great 4BR/4BA brick home situated on a spacious cleared tract of land with just the right amount of trees. The home features custom kitchen, both tile and carpet flooring, and beautiful granite counter tops. The living room is inviting with custom wood work and a fireplace that is warm and welcoming. The bedrooms are generously sized. The home comes with a 2 car detached garage and a nice work building and a great back porch. Did I mention that it also has 2 half baths?


text:
sorrow Syndra by Xano501Watch
©2012-2016 Xano501
i almost got confused with mirajane
Reason for tears? SMOOCH!!!!
why r they flowing? because you have 750 stacks now but srsly 'flails' STOP CRYING 'slaps' you're the only girl in the league who's got balls NO YOU TWO DON'T COUNT 'ori ahri'
Wow this picture captures Syndra very well i feel. Powerfull but lonely.grown up but still a child in heart. Very well drawn.
I like your style.
.......and now I'm depressed....will you ever draw her smiling happily?
it's only surprise sex
Syndra: The Most powerful being of all Valoran, yet the lonelyest of all the champions... Guess who eats alone between matches?
drawing =10/10
Engrish =4/10
Engrish =4/10
Somehow she looks like Reinforcer....
does anyone else have the sudden urge to wipe away her tears and hold her?
No, but I do feel the need to gank her, mainly because my friggen ziggs is losing mid to her... Again!!!!
Here's one. As a summoner, it's my duty to comfort any champion in need
so nice its amazing i love the expression
I absolutely ADORE this picture, its so beautiful and it makes you really feel heartbreak.
So awesome.
don't cry Sindia-chan
This is incredible, well done!
Syndra should cheer up.....I shall be summoning her to the rift for Complete dominance.
This is really good. nice job
This is really good. nice job
Awww, this is a beautiful image of Syndra!
Wow this looks great! fav'd
Great job especially the tears and the flowing hair.A job well done.
oh, poor girl...she mustn't like fighting huh?
D'aweeeeeeeeeeeeeee But i love Syndra! <3
oh my gosh its so good!
Wow, that's my favourite Syndra drawing ever. Great job!
<3 Syndra, nice drawing to show her emotional side
so cute *O*
looks awesome!!!
nice, i dont know why she is but i wish she'd stop crying


text:
FORT PIERCE, Fla. — A Florida military museum wants to acquire objects from Sunday's rescue of an American hostage by Navy SEAL snipers.
The director of the National Navy UDT-SEAL Museum in Fort Pierce said it would be a shame to not collect items from the operation.
Michael Howard says the museum has talked about trying to get the lifeboat that Capt. Richard Phillips was held hostage in for five days but called that a stretch.
The standoff ended late Sunday when U.S. Navy snipers fired from a warship and killed three Somali pirates aboard the lifeboat, which was pitching in the open sea at nightfall.
- Watch video of the newly-freed Capt. Phillips.
- View a gallery of photos covering Capt. Richard Phillips' ordeal off the Somalia coast.
- Watch video from Maersk Line Limited President and CEO John Reinhart talking about the rescue of Capt. Richard Phillips.
- Watch video from a Phillips family spokesperson talking about the rescue of Capt. Richard Phillips.
- View this interactive graphic that details modern piracy off the coast of Somalia.


text:
I was involved in an email thread this week about optimization and a discussion of the ability to prepare SQL statements (as ADO, ADO.NET and Fox all let you do) before running them came up. There is an on going misconception about prepare. There are a couple of issues around preparing statements:
Anyway, I found this interesting and thought you might as well.


text:
SWAT teams members in full gear make their way to a suspect's house. A bomb robot is deployed. Actor Steven Seagal approaches the house, riding in a tank.
No, it's not the latest action B-movie. It's a real-life arrest.
Phoenix TV news station KPHO reports that Sheriff Joe Arpaio sent dozens of SWAT team members, armored vehicles, a bomb robot and the aging action film star when the Maricopa County Sheriff's Office executed a search warrant for a man accused of cockfighting.
The homeowner, Jesus Llovera, was alone and unarmed when he was arrested on suspicion of cockfighting.
In probably the most telling moment of all, a neighbor told reporters that Seagal's tank came in and pushed down a wall only to reveal a bunch of chickens.
Llovera's attorney said he believes there was no probable cause to believe his client was dangerous and the massive display of force was only used to boost ratings for Steven Seagal's reality TV show "Lawman."
The Sheriff's Department and Seagal apparently have a contract that has him tag along with the sheriff when arrests are made.
And as a sad postscript to this bizarre saga, 115 birds were euthanized on the spot. Won't somebody please think of the chickens?
-Chance Welch
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text:
100' Orange Extension Cord 02309-88-03
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text:
Pharmacy Fremantle
Western Australia > Fremantle Directory > Health and Medical > Fremantle Pharmacy
Your search returned 10 Fremantle Pharmacy listings
Fremantle PharmacyBasic Listings
Woolstores Chemmart ChemistPhone: (08) 9430 4899 Address: Shop 12, Woolstores Shopping Centre, Cantonment St, Fremantle, WA | Report
Woolstores PharmacyPhone: (08) 9430 4594 Address: Woolstores Shopping Centre, Fremantle, WA | Report
Fremantle Drive-in PharmacyPhone: (08) 9335 9633 Address: 197 High St, Fremantle, WA | Report
Fremantle Skin Cancer ClinicPhone: (08) 9336 1884 Address: 6/87-89 South Tce, Fremantle, WA | Report
Friendlies Chemist FremantlePhone: (08) 9336 2277 Address: 7 Adelaide St, Fremantle, WA | Report
Wray Avenue PharmacyPhone: (08) 9335 6616 Address: Shop 5, 1 Wray Ave, Fremantle, WA | Report
Port PharmacyPhone: (08) 9335 2404 Address: 56 Market St, Fremantle, WA | Report
Fremantle Central PharmacyPhone: (08) 9335 2786 Address: Queen St, Fremantle, WA | Report
Priceline PharmacyPhone: (08) 9335 8052 Address: 4-6 Adelaide St, Fremantle, WA | Report
Fremantle Central PharmacyPhone: (08) 9335 2786 Address: Shop 1, 2 Cnr Cantonment Rd & Queens St, Fremantle, WA | Report
Pharmacy in FremantleIf you own a business in Fremantle and would like to have your business listed here then add your business to the guide. You can get a Classic Listing where you will be able to feature your business including a photo, opening hours, specials and more in our Fremantle Pharmacy directory.
Related terms: Fremantle 24 hour pharmacy, Fremantle amcal pharmacy, Fremantle chemists, Fremantle discount pharmacies, Fremantle drug stores, Fremantle medications, Fremantle medicines, Fremantle pharmacists, Fremantle pharmacy, Fremantle prescriptions, Fremantle terry white pharmacy
Pharmacy in surrounding locationsCanning Vale Pharmacy Willetton Pharmacy Spearwood Pharmacy Myaree Pharmacy Booragoon Pharmacy
Browse other businesses in Fremantle
Phone: (08) 9433 1018 | Location: 75 wray avenue, Fremantle, WA | Web: http://www.yogavedawellness.com
yogaveda is a yoga and ayurveda wellness centre. offering daily yoga classes catering for beginners, general, pregnancy, restorative and sell yoga equipment. our qualified ayurvedic practitioners offer consultations, treatments and we stock herbs & oils
Phone: 0408 885 435 | Location: 96 Wray Ave, Fremantle, WA
Perths Leading Grass Tree Supplier
Nature Calls Portable Toilets
Phone: 0416 911 079 | Location: 10C Wood St, Fremantle, WA
Nature Calls Portable Toilets provide the highest quality portable toilet with hygiene, cleanliness, service and quality our guarantee.
See the Pharmacy main category for all Pharmacy business listings.


text:
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Template:Did you know nominations/Chris Hewitt
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- The following is an archived discussion of Chris Hewitt's DYK nomination. Please do not modify this page. Subsequent comments should be made on the appropriate discussion page; such as this archived nomination's (talk) page, the nominated article's (talk) page, or the DYK WikiProject's (talk) page. Unless there is consensus to re-open the archived discussion here. No further edits should be made to this page. See the talk page guidelines for (more) information.
The result was: promoted by Miyagawa (talk) 10:38, 9 February 2013 (UTC)
Chris Hewitt[edit]
- ... that Baltimore Ravens assistant special teams coach Chris Hewitt was hired by Ravens head coach John Harbaugh, who had coached Hewitt as a 17-year-old freshman with the Cincinnati Bearcats?
- Reviewed: Mo Cowan, Nickson Fong, Bermudian cuisine and Cardboard bicycle.
Created by Alansohn (talk). Self nom at 15:47, 1 February 2013 (UTC)


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Median pay for Physiotherapists in the United States lies in the neighborhood of $61K per year. Experience level and the particular city each impact pay for this group, with the former having the largest influence. While one in four report receiving no health benefits, a fair number do receive medical coverage, and more than a third have dental, as well. Women are just slightly outnumbered, with male Physiotherapists making up 59 percent of survey respondents. Job satisfaction is reported as high by the vast majority of workers. The data for this snapshot was collected from individuals who took PayScale's salary survey.
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Physiotherapists are responsible for providing physical therapy for patients on behalf of their organization. They conduct different therapies such as exercise programs and joint manipulation to help heal bodily symptoms and improve patients' quality of life. Physiotherapists interact with patients to learn about their issues and concerns, develop a treatment plan and conduct follow-up to see how the treatment plan is working. Some of their main responsibilities include setting up exercises that address coordination, posture and strength issues, as well as using their hands and tools to alleviate physical problems. Physiotherapists communicate with patients' families, counselors and other therapy providers on a regular basis as well. These professionals work in a health care environment and must follow strict safety and privacy regulations to respect patient privacy and confidentiality.Read More...
A bachelor's degree in physiotherapy is generally the minimum educational requirement for this position; registration or licensing may be needed as well. Previous experience in physiotherapy is typically required or preferred. Physiotherapists must have a good understanding of the techniques they apply to eliminate pain and discomfort in patients, and they must work well with other physiotherapists in a team setting and on their own with minimal supervision. They need to be able to stand on their feet for several hours at a time, as well as have excellent patient care skills.
Median of all compensation (including tips, bonus, and overtime) by years of experience.
Those who have worked for fewer than five years take home a median salary of $61K, and workers with five to 10 years of experience earn a higher $64K on average. Physiotherapists bring in $76K after working for 10 to 20 years. Physiotherapists who claim more than two decades of experience actually make somewhat smaller average paychecks of $69K.
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41 %
59 %


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Current Residence: Washington
Favourite genre of music: I really enjoy any genre, of music, but I prefer Rock/Metal
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Favourite style of art: Anime/Manga but I love all types of art!
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Favourite cartoon character: Squall or Kratos
Personal Quote: Never under estimate the power of a redhead (that is so not my own quote!)


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EPQ - good idea?(28 Posts)
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Monday, March 11, 2013
5 comments
I am so thrilled to go back on DST. Ironically, I hate making the change-over because I don't really like going to bed earlier and REALLY don't like getting up earlier. But I am sick to death of walking the dog in the dark every night; it's depr... Read more
Tuesday, January 29, 2013
3 comments
I discovered No S back in 2009 and truly never thought I would be back having to pay so much attention to my diet. BUT 2012 turned out to be a crazy stressful year and I just let go of my good habits. Death of a pet, death of my father-in-law, h... Read more


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Even though his people are their enemies, a tribe of Native Americans adopts a young Viking boy after he is accidentally abandoned on their shores. When the Vikings return several years later, the now grown young man (Karl Urban) finds himself caught between the warring Norsemen and his Indian family.
|MPAA Rating
|Theatrical Release
|April 12, 2007
|Karl Urban, Jay Tavare, Nathaniel Arcand, Moon Bloodgood,
|2007 20th Century Fox
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I upgraded my site to 3.1, then enabled Network and added a site as a subdomain. I edited wp-config.php and .htaccess as indicated and added a wildcard subdomain on my hosting control panel. I have it pointing to the same hosting subscription as my main domain.
When I try to access the site (dashboard, front end, whatever) it forwards to the main domain: omd.e-business.ie -> e-business.ie
I had some additional rewrites in the .htaccess from when I moved the original site from a static site to WP. I've deleted them thinking that may have caused the redirect but it didn't.
Did I miss any other steps?


text: Hello, I am pondering a topic and i cant quite find the answer that i am looking for. It concerns amp draw. I understand ohms law and the relationships it entails. I am confused with the idea that people say a device will draw more amps than it is supposed to and cause things to burn up. I understand the idea of putting too much power to something and burning it up, but i am just making sure that my thought pattern is correct for the contex of "drawing too much current" if you have x amount of voltage and x amount of resistance, then you can only draw a certain amount of current, correct? Just because you have a smaller wire (which will increase the resistance) does not mean that you are pulling any more amps or volts, rather you are decreasing them right? So the wire will burn up, and not the device it is connected to? That was pretty mush moshed because i am having a hard time explaining what i want to know. I guess i could ask just directly: 1.) can you burn up a device by using too small of a power cord? (other than a motor) 2.) When considering power (P=IV) how can you possibly put less voltage onto something and it draw way more current? Like if you had something that was rated 120v 400w, would it burn up if you only hooked 2v to it? the current would then be 200amps instead of 10/3?? This idea goes against my understanding of ohms.