text:
By Sandi Bush
Grizzly Flat Fire Safe Council
It's 96 degrees on Tuesday, Sept. 3, around 2:30 p.m. and there is a steady northwest wind blowing at 28 mph, with some gusts up to 40 mph.
The end of the Labor Day Weekend finds many residents in Grizzly Flat at home adding one more day to the holiday. Leoni Meadows Camp is full to capacity with some 500 campers and 100 staff members.
Most Grizzly Flat "weekenders" are already packed and headed down the hill, when Susan Foster steps out onto her back deck on Tyler Drive and is greeted by a huge plume of smoke coming from the north on the Tyler Ranch. She hears her neighbors yelling about the smoke as she dials 911.
Chief Bob Gill of Pioneer Fire Protection District (PFPD) with engine 38 is first on the scene.
That was the scenario created by Mark Almer, chairman of the Grizzly Flat Fire Safe Council, for the council's table-top drill exercise in April. Sixteen different agencies participated, working their way through the drill as if it were a real-time, real-life emergency.
Chief Bob Gill of PFPD and Battalion Chief Charlie Blankenheim of Cal Fire ran a shared Incident Command Center (ICC) located at Grizzly Flat Community Church on Sciaroni Road.
As with real-life emergencies, the two-hour exercise included multiple developments for the ICC to deal with as the fire worked its way through the area known as Unit 2 on Tyler Drive towards the community water district plant.
The incidents tested the resources of those agencies participating in the paper exercise. Firefighters responded to structure fires, including one with a family trapped inside. A car accident victim required a helicopter evacuation.
As the fire raged east toward the area known as Unit 4, on Winding Way, the order was given to evacuate Leoni Meadows Camp. Transporting 600 people was a good test for the exercise and required the cooperation of multiple agencies to accomplish.
Although this was a paper drill the scenarios were very real and vividly represented what could happen in a wildfire.
During the critique following the drill, there were many shared ideas and comments on how to deal with specific challenges presented in the exercise to the different agencies who participated. It was determined that an exercise of this type should be done every three to five years.


text:
swimmingpool by TIT0Watch
very very very good work
is it possible to make a tutorial about this icon
Damn this is great
Awesome work my dude!!!
Саша, сделай одной урок как делаеш в Фотошопе такие прекрасние работьй. Всем ждем
WOW, that's all I can type for now O_o
Excellent work Keep it up!
WOW Nice work I like it
Is this awesome or awesome?
nice work
i'm just amazed with your work
Tutorial would be great.
So fresh...
Just woah...!
Wooow this not look made in photoshop!!
Amazing!!! looks soo fantastic!
Amazing!!! looks soo fantastic!
It's awesome! Where did you learn it?
Nice work
If there was a DeviantArt Idol contest I believe you'd be high ranked
awsome !
nice work
very professional
very professional
Very nice!
Oh my god!
it's very very well done! awesome!!
You're crazy, did you know that? hehe Great PS master, your precision and patience are one of a kind!
jajaja you're big my friend!! so big!!
that is pretty impressive
that is pretty impressive
Сашка ты зверь!!! чистой воды же 3Д..а оказывается шоп
woah... i lost my words, and this in photoshop
it is so perfectly done... very good job, great creativity
amazing!u made it only by photoshop???
photoshop ?
ajauhahahuaha, so amazing
perfect !
amazing, do you think you could post some steps you took while making this
simply.. wow!
jesus christ! that's terrific
geeze thats some nice water effects. And the tiles in the pool are all perfect , nice job
photoshop ...
very cleaver !!
very cleaver !!
omg Great!
Thats great, could deserve a DD
Look I´ve gotta it , no way
looks like someone used your pool as bathroom
just messing around
looks great
just messing around
looks great

subset: commoncrawl


text:
IVF and Fertility Specialists Clinic
Artificial insemination with donor sperm - donor IUI
Page author Richard Sherbahn MD
Who should be treated with donor insemination?
Donor insemination (or donor IUI for "intrauterine insemination") can be used as an effective treatment for male factor infertility or for single women who desire children.
ICSI (intracytoplasmic sperm injection) can result in pregnancy in very severe male factor infertility so that many cases that would have required donor sperm in the past can now have pregnancies with the male partner's sperm.
How is donor insemination performed?
IUI success rates using donor sperm
Pregnancy success rates using fresh (not frozen) donor semen were quite a bit higher than with frozen semen. However, use of fresh donor semen was abandoned in this country many years ago after some reported cases of HIV transmission following donor insemination.
Call our office for current pricing for insemination with donor sperm.
|© 1996–2015 Advanced Fertility Center of Chicago, S.C. All rights reserved


text:
Stream View of Anchor, an Twitter client made by users for users, designed for iOS 7, waiting to be developed.
Anchor Menu Screen (Pop-Up)
Anchor Timeline Screen
I am already searching for a developer that wants to develop Anchor and launch it on the App Store, it could be a great experience and adventure.
If you want to help me, Contact me mate!
You can follow me on Twitter at @menpalapps.
Don't forget to press "L" and follow me please :)
keyboard shortcuts:
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Show and tell for designers
What are you working on? Dribbble is a community of designers sharing screenshots of their work, process, and projects.
Copyright © 2009–2016 Dribbble LLC. All screenshots © their respective owners. Shipped from Salem, Mass. USA.


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A tangy, sweet sauce.
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Fat Toad Farm's unique goat's milk caramel sauces combine rich, sweet caramel with the subtle tang of goat's milk for a creamy, not-too-sweet dessert sauce unlike anything we've tasted. We love it with ice cream, fruit, and cheeses -- and to be honest, straight from the jar. This silky caramel is actually a traditionally Mexican preparation called cajeta, and Fat Toad Farm makes our favorite version.
The set includes one jar of original caramel sauce and one jar of vanilla bean caramel sauce. Each jar is housed in a hand-stamped burlap gift bag tied with a wooden spoon (for expedited eating, of course).
Sourced from: Fat Toad Farm
365 day shelf-life. Refrigerate after opening.
Standard Shipping: Ships out within 2 business days.
Three-Day Shipping: Guaranteed delivery by Thursday, February 11.
Overnight Shipping: Guaranteed delivery by Tuesday, February 9.
Additional Shipping Information: Cannot be shipped to U.S. Territories or P.O.Box/APO/FPO/DPO addresses.
Note: Additional charges apply for shipments to Alaska and Hawaii.
A dessert that won't let you down
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Jane White Is Sick & Twisted [2002]
Genre: Comedy, Drama, Romance
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Chicago Public Media
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Tennis becomes more accessible on South Side
Aug. 27, 2015
Journalist Ben Austen has been following the efforts of a group of tennis enthusiasts in Chicago's Hyde Park and Bronzeville as they try to make tennis the sport of choices for young African Americans.
Women still face gender bias in math, science fields
Oct. 9, 2013
A closer look into why the upper echelons of math and science continue to be dominated by men, and how women are striving to close the gender gap.
Ricketts family caught up in ad controversy
May. 17, 2012
The patriarch of the family that owns the Chicago Cubs is caught up in the middle of a political controversy over a proposed ad that links President Barack Obama to inflammatory remarks made by Rev. Jeremiah Wright.
Paper paywalls now a global phenomenon
Mar. 20, 2012
Listen to Ken Doctor on paywalls
New York Times
' readers will soon find themselves facing a taller paywall.
3 at 3: Three ways to succomb to distractions (and be happy about it)!
Feb. 21, 2012
A stamp of approval for texting, tweeting in theaters
Nov. 30, 2011
New York Times
reported late Monday that a theater near Seattle, the Tateuchi Center in Bellevue, has announced it will allow "nondisruptive" cell phone use during at least some shows.
Daily Rehearsal: The Blues Brothers take Chicago (again)
Jul. 8, 2011
The All New Original Tribute to the Blues Brothers
is wending its way through Chicago, and they did a special performance outside the Thompson Center today at noon, much to the delight of passersby.
Undressing the street-style of NY Times' Bill Cunningham
May. 21, 2011
Bill Cunningham, facing down a deadline, eggs himself on with the line 'let's get snapping and cracking'. Tthe photographer at work is the subject of the new documentary
Bill Cunningham New York
now at the Music Box.I'm a long-standing, (okay, rabid) fan of Cunningham's New York Times
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14 Toilet Paper Roll Craft Ideas
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Mother's Day Mini Book
By: Avital Gertner-Samet of Creativity Prompt
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For the coming Mother's Day treat your mother like a valentine and send her a series of micro love-letters assembled together in a mini book she can carry around in her bag. I am sure your mother will treasure the handcrafted gift as well as the heartfelt messages you've included inside.
- 1 sheet of white cardstock – American Crafts
- Journaling stamps – Maya Road Foundations Journaling and Li'l Davis Designs Journaling 1 (variations – journaling die-cuts, shaped die cuts, mixed media, mini envelopes, etc.)
- Colorbox chalk ink queue
- 1 die cut shape – Scenic Route Summer Die Cut Arrows
- 1 piece of colored 4" by 2 1/2" textured cardstock - American Crafts
- 1 Brad (3/16")
- Letter stickers - Making Memories
- Scissors
- Crop-a-dile – We Are Memory Keepers
- Stamp your journaling tags in various colors of ink on a white cardstock.
- Cut the stamped tags out with precision scissors. Tip - Tilt your scissors in 30 degrees away from the cardstock and turn your cardstock rather than the scissors for a more precise and controlled cut.
- Gather all your journaling tags in a way that appeals to you. Play with different colors and sizes for an added visual interest. Punch a hole through all the tags to insure an even placement. Make sure they are all positioned correctly, so they won't tear from the punch.
- Write 10 micro love letters, each enumerating a reason why you love your mom. Write down memories both from your childhood and the present time. You can also include tiny punched out pictures of you and your mom together from various times and stick them on the back of the tags.
- Journaling variations – 10 lessons you have taught me, 10 reasons why you are the greatest mom, 10 traits I have inherited from you, etc.
- Use a die cut shape as the cover for your mini-book and decorate it with letter stickers and a heart-shaped die-cut (suitable for a valentine...)
- Assemble all your journaling tags, the cover and the 4" by 2 1/2" piece of cardstock as the back cover, and attach them together with a jumbo brad.
- Give your mother the gift of love!
Creativity Prompt is a blog designed to boost your creativity with heaps of inspiration, journaling and creativity prompts, updated weekly. Check out the video tutorials on Creativity Prompt as well as the step-by-step instructions for creating loads of creative, fun and easy projects.
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Man faces felony trespassing chargeOctober 02,2013Man faces felony
trespassing charge
BENNINGTON A local man is facing a felony charge after a woman told police he came into her home Aug. 29 and trashed it.
Tylor McDonald, 21, of Bennington, was arraigned in Bennington criminal court Monday on a felony count of unlawful trespass into an occupied home. He pleaded innocent and was released without bail.
In an affidavit, Officer Thalia Hudson of the Bennington Police Department said she went to a womans home around 12:35 a.m. Aug. 29 after the woman reported that McDonald had come into her home and flipped over furniture.
The woman told Hudson that McDonald had tried to get into her home but she wouldnt let him in and told him to leave. However, the back window was open and McDonald was able to get inside.
The woman called a friend for help and the friend also told police she saw McDonald in the house.
According to the woman, McDonald flipped the furniture over because he was mad.
McDonald had been served a no trespass, order which forbade him from being at the womans home July 27.
According to Hudson, McDonald was convicted in March of unlawful trespass onto land, disorderly conduct and resisting arrest.MORE IN This Just InPROCTOR A citizen committee has finalized a survey to poll residents on a new town office... Full StoryAn attorney for environmental advocate Annette Smith has asked the Vermont attorney generals... Full StoryRANDOLPH CENTER A Midwest farmer with an innovative approach to managing his dairy operation... Full Story
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text:
Funding via KREDIT Ltd.
Mrs. N. and her family members are seeking to improve their standard of living and to generate a better income. Therefore, N. is asking for a loan of $1000 US to purchase a motorbike to more easily commute to the market to buy goods. The motorbike will also help one of her family members to travel to work more easily and cut back on using public transportation services. This is her second loan from CREDIT, Kiva's partner. The photo shows N. with her son.
Success!! The loan was 100% repaid


text:
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$119.99 MSRP (actual price may vary)
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Let us know if you think we should continue to search for the best prices for this product.
What It Is
The LEGO Ninjago Epic Dragon Battle set comes with 915 pieces and has plenty of building challenge. Once it's done, there's plenty of play as well. Like all of the Ninjago sets, this one takes kids into another chapter of the Ninjago legend. The Great Devourer has been awakened and threatens to devour the world of Ninjago. The only hope is the green ninja riding his four-headed Ultra Dragon. And, of course, the battle between the evil Lord Garmadon and Sensei Wu continues.
The set comes with seven minifigures: Lloyd ZX, Jay ZX, Sensei Wu, Lord Garmadon, Acidicus, Kalidor, and Chokun. Kids can build the four-headed Ultra Dragon with extendable wings, a flame sphere shooter, and a flexible body and tail. It also has a carry handle to make it easy for kids to pick it up and fly it around. Kids will also build The Great Devourer, which also has a flexible body and an opening mouth with space for a minifigure inside, and the snake prison, which features an opening gate and space for a minifigure with a snake venom trap. Weapons include a Hypnobrai fang blade with blue anti-venom capsule, all four golden Spinjitzu weapons, and seven regular weapons.
Is It Fun?
This is a really big set with lots of built-in play value. For Ninjago fans, this ultimate set will inspire all kinds of building fun and active imaginative play.
Who It's For
LEGO Ninjago Epic Dragon Battle is for ages 8–14.
What To Be Aware Of
The set took us about three hours to build. No matter how long it takes you to build, remember that building is part of the fun of LEGO.
Once built, The Great Devourer measures 13 inches long. The snake prison measures 10 inches tall and eight inches wide. The Ultra Dragon measures 20 inches long, 14 inches wide, and nine inches tall.
Magformers Neon Color 60 Piece Set
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from LEGO
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First Builders Zoomin' Vehicles
from MEGA Bloks
LEGO Star Wars First Order Battle Pack
from LEGO
LEGO Marvel Super Heroes Carnage's SHIELD Sky Attack
from LEGO
Despicable Me Minion Made Factory Fiasco
from MEGA Bloks


text:
I would like to clarify very important issue, which is the blog subject, what is the different between ALM and TFS as a part of Visual Studio Team System (VSTS) , first of all let's know what every abbreviation means:
ALM : Application Lifecycle Management
TFS : Team Foundation Server
But really it isn't what I mean by the different between them, definitely there is a big different between both, first of all let's start to define each one:
ALM is a continuous process of managing the life of an application through governance, development and maintenance
TFS is a Microsoft tool that we should use to implement ALM, while as mention before it's a part of Visual Studio Team System .
Also there are a map between both, ALM has 9 process area and TFS has many Product features, I will map every TFS feature to one of Process area to help for implementing ALM at the Software house for their Software Application, first lets list ALM 9 process area and TFS features:
ALM 9 Process areas:
User Experience (UX)
User Experience (UX) is a term used to describe the overall experience and satisfaction a user has when using a product or system.
Requirements Management
Requirements management is the science and art of gathering and managing user, business, technical, functional requirements and process requirements within a product development project.
Quality & Test
Quality Assurance covers all activities from design, development, production, installation, servicing and documentation. The main goal of QA is to ensure that the product fulfills or exceeds customer expectations.
Code Quality
The way a program is written has important consequences for the maintainers. Some quality code attributes; • Readability • Ease of maintenance, testing, debugging, fixing, modification and portability • Low complexity • Low resource usage
Architecture & Design
Consists of software components, their external properties, & their relationships. Documenting software architecture facilitates stakeholder communication, documents decisions about high-level design, & allows reuse of design components & patterns.
Project Management
Project management is the discipline of organizing and managing resources in such a way that these resources deliver all the work required to complete a project within defined scope, time and cost constraints.
Software Configuration Management
The management of the various configurations of hardware and software components within the technical environment and enables recreation of each build as well as recreation of earlier environments in order to maintain previous versions of a product.
TFS Features:
Work item tracking
Work item is unit of work which used to identify, manage and track any piece of work in the project like (Task, Bug, Risk,OoS,...) with different status (Active, resolved, closed,...) and can be associated with projects documents.
Source code control
Enterprise scale repository for source code and other file-based documents, support branching and merging operation and check-in policy
Automated Build
Automated compilation of source code, Execution and automated test, Performance of source code analysis with daily build automation
Metrics and Reporting
The most favorite features for project managers some reports into metrics stored within TFS Data warehouse
Project Portals
For every Team Project VSTS creates and associated project portal which build on WSS, Maintain the documentation produced by the project team and They also have collaborative functionality such as version history and document check-in and check-out
Office Excel and Office Project Integration
Integration with VSTS work item services and theWork item repository is fully accessible through office project and office excel providing two-way synchronization (between work item and MS Excel and MS Project
Now I will map every process area with the TFS feature that we could use to implement ALM on the software lifecycle which improve the quality of software at the end:
Process Area
TFS Feature
· Using Architecture features in VSTS
· Project Portals
· Office Excel Integration
· TFS Template (MSF for CMMI or MSF for Agile) with workitem tracking
· Automated Test and Quality Metrics (features in VSTS)
· Automated Build
· Quality Metrics
· check-in Policy
· Metrics and Reporting (reporting based on reporting services)
· Office Project Integration
· Source code control
It's absolutely important to be sure that delivering a high quality solution comes from healthy, well managed, controlled, collaborated, integrated and monitored environment. Simply you could create this environment by encourage software house to understand ALM (application lifecycle management and how to implement it by using tools like TFS (Team Foundation Server).


text:
Welcome Class of 2019!
Dr. Anne Charity Hudley Welcomes the Newest William and Mary Scholars
Dear Scholars in the Class of 2019,
Congratulations on your designation as a William & Mary Scholar! Your award represents the accomplishments and achievements that you have earned so far in your academic career and you should be truly proud.
The William & Mary Scholars Undergraduate Research Experience (WMSURE) is a unique program that was developed to provide resources to you so that you might pursue undergraduate research experiences at William & Mary. WMSURE is also designed to encourage you to continue your education at the graduate level. Examples of WMSURE activities include: personalized advising, funding for research and travel (by application), weekly workshops, social activities and guest speakers designed to your specific interests.
I would like to invite you and your family to learn more about the William & Mary Scholars Undergraduate Research Experience (WMSURE) on April 11th during the Day for Admitted Students program at either 1:00 pm or 2:00 pm in the James Room of the Sadler Center. I would also like to invite you to our new ESCAPE Research Program on Sunday April 12th from 10:30 am - 5:00 pm in Tidewater AB of the Sadler Center. ESCAPE Research is exclusively for admitted William & Mary Scholars.
At ESCAPE Research, you will meet faculty and students who are actively engaged in research and will tour William & Mary's research facilities that aren't included on general admission tours. Parents are invited to join us at the end of the day for a question and answer session. Please be sure to also register for the Day for Admitted Students and ESCAPE.
As you make your decision, please feel free to join us on Facebook and twitter to learn more.
I look forward to seeing you and yours on the weekend of April 11th!
Associate Professor of Education, English, Linguistics, and Africana Studies
William & Mary Professor of Community Studies
Director, William & Mary Scholars Program


text:
At this point, you have already conquered several obstacles. You have proven yourself able to meet all six of the requirements to begin CNA training, you have completed all of the necessary training courses and now you are facing the final obstacle in your road to becoming a Certified Nurses Assistant—the certified nursing assistant exam. With both a written and a practical exam, sufficient preparation is a definite must. By using a study guide, you will be able to streamline your studying and be more confident in your level of preparation. Several study guides are available, many of which are free. The following information will help you both locate and choose the best free CNA study guides.
Practice Tests
A great way to prepare for any exam is to take a full-length practice test. There are several free practice tests online, but make sure to select a test that closely resembles the actual test you will be taking. One excellent source for free practice tests online can be found at www.cnapractice.org. This site offers a full, 70-question test and allows you to go back over the exam after you have completed it to review the questions you missed. Any questions you miss will have an in depth explanation for why your answer was incorrect. This test very closely resembles the actual exam in the topics covered, the level of difficulty, the number of questions, the time limit, navigations and even the appearance of the exam. If you would rather practice with a paper test www.medicalcareersite.com offers a full-length practice test/answer sheet/answer key PDF file that you are free to download and print.
Training Videos
To study for the hands-on portion of the test, begin reviewing your skills with the free CNA training videos available at www.medicalcareersite.com. Watching the videos, you can refresh all the skills that you learned through your training courses. Www.cnatips.com also offers a variety of training videos to help you prepare. This site is also able to provide exact CNA testing information for each applicant.
Phone Applications
While it may not be available to everyone, those that have an iPhone, iPod or iPad are able to take advantage of a free and easily accessible resource through the Apple Applications store. At www.appshopper.com, you can download a free CNA study guide application. Easy to use at any time, this guide includes 152 questions, quiz cards and enjoyable quiz formats that test your skill level and knowledge to help you better prepare for your upcoming CNA exam.
While there may seem to be an insurmountable amount of information to retain and review, there are resources to help you pass your CNA exam. In addition to reviewing the notes you took in training, take advantage of the many other free resources available online such as the free full length practice tests, the skills training videos and even downloads from application stores! Prepare with your free study guide aids and take your exam with confidence!
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text:
Borgfelde hotels
Borgfelde is a lovely Hamburg borough that offers a quiet and scenic lodging base for holidaymakers who want to enjoy the German capital but don't want to stay in the expensive city centre near the bustle and noise. This little hamlet is close to numerous green parks and like Hammer Park, Jacob Park, and the beautiful Außenalster Lake. Establishments like the Literaturhaus Cafe, where one can enjoy fine coffee along with poetry readings, add a distinctive cultural flair to the beautiful surroundings. One can enjoy a variety of plays, from Shakespeare's Macbeth to contemporary productions, at the Thalia Theatre.
- Watch the exciting German Gallop Derby and numerous other exhilarating horse races at the stylish Hamburger Renn-Club, which has been in service since 1852.
- Admire beautiful sculptures and fountains, exquisite handkerchief, witch hazel, and hazelnut trees and delicate Siberian squill and peonies at Stadtpark, only five kilometres from Borgfelde.
- Enjoy laser shows featuring jazz, classical, or modern rock music and intriguing multi-media exhibitions related to astronomy and other scientific studies at the state-of-the -art Cosmic Theatre in the Hamburg Planetarium.
Hamburg Airport is only ten kilometres from Borgfelde via the B5 highway, and passengers can take the S-Bahn commuter rail from the airport to the central rail station. The rail station is served by the Inter City Express (ICE) lines and direct trains from other major German cities as well as cities in Austria, Prague, and the Czech Republic. The A1, A7, A23, and 24 Autobahn highways connect to the city from all over Germany, and the central bus terminal serves numerous European cities. Public transportation options in Borgfelde include the S-Bahn, U-Bahn, buses, and taxis.
Recommended hotels
1 Wyndham Garden Hamburg City Centre Berliner Tor
Borgfelder Strasse 1-9 Map
Free WIFI/ WLAN & Free Parking
Creating an ideal atmosphere for a relaxing stay, Wyndham Garden Hamburg City Centre Berliner Tor is the right choice of accommodation, while visiting Hamburg. GeneralTravellers at Wyndham Garden... More
2 Novotel Suites Hamburg City
Lübeckertordamm 2 Map
Rate includes Breakfast
Offering comfort and functionality, Suite Novotel Hamburg City Hotel makes for an ideal base for business and leisure travellers while in Hamburg. This value-for-money hotel is within convenient... More
3 AandO Hamburg City
Spaldingstrasse 160 Map
FREE WiFi in entire hotel
With modern, comfortable and budget-friendly accommodations set accessibly in the city, A&O Hamburg City makes for suitable starting point for travellers spending time in Hamburg City. While in... More
4 Quality Hotel Ambassador Hamburg
Heidenkampsweg 34 Map
Ideal for business and leisure travellers, the Quality Hotel Ambassador Hamburg lets you unwind, refresh and be yourself in a pleasant and relaxing environment. GeneralBusiness travellers can... More
5 Novotel Hamburg City Alster
Luebecker Strasse 3 Map
Rate includes Breakfast
Located in the heart of the Hanseatic City of Hamburg, the Hotel Novotel Hamburg City Alster offers fabulous accommodation and overhaul service to set your journey apart from the rest of the world.... More
6 Apartment-Hotel Hamburg Mitte
Borstelmannsweg 133 Map
Offering unique service and congenial atmosphere, the Apartment-Hotel Hamburg Mitte is an excellent place for a fun filled vacation. General Apartment-Hotel Hamburg Mitte also provides services... More
7 Holiday Inn Express HAMBURG CITY CENTRE
Lübecker Strasse 109 Map
Park & Fly- Includes up to 15 days of parking
Holiday Inn Express Hamburg City Centre offers comfortable accommodation and quality services to make the stay of the guests enjoyable. Hagenbeck Tierpark, St. Michaels Church, Botanical Garden and... More
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Best Western Hotel Hamburg International offers quality service in a warm and friendly atmosphere. This hotel offers direct access to the city centre and main railway station. Musical Konig der... More
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Motel21 Hamburg Mitte invites travellers to simply-appointed and well-maintained accommodations while in a business or recreational trip to the historic city of Hamburg. Guests at this Germany... More
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Yoga Nidra on the Winter Solstice - Ongoing/Yoga Events Series
|Whole Yoga & Pilates - Yoga Event ***Ongoing Yoga Events/Series
|Yoga Workshop:
|Yoga Nidra on the Winter Solstice
|Odenton MD USA
|Yoga Class
|Whole Yoga & Pilates
|Kate will lead this delightful restorative practice. You'll begin with gentle postures to ground and prepare the body, then enjoy a session of "yogic sleep." This guided meditation is profoundly healing and accessible to all, and a perfect way to enjoy a moment of stillness before connecting with family and friends over the holidays. Saturday, December 21, 12 noon-1:30 pm. Please email email@example.com or contact the studio (www.WholeYoga.net) to reserve your spot; $20 in advance.
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Chapel built in 1817, from plans drawn by architect François Baillairgé. High altar by Eugène Taché. Two statues dating back to 1750 are attributed to Pierre-Noël Levasseur. Statues of Ignatius of Loyola and Peter Claver sculpted by Louis Jobin. The Way of the Cross was done by Médard Bourgault. Two recumbent figures representing the Canadian Martyrs by Alfred Laliberté.
Guided tours: and free visit : June 17 to September 8, Tuesday to Sunday, 12 p.m. to 5 p.m. Closed on Monday. September 9 to October 19, Saturday and Sunday, 12 p.m. to 5 p.m.Free admission.
Schedule and rates are subject to change without notice. Visit their website or contact them for up-to-date information.
20, rue Dauphine
Québec, QC
Borough of La Cité - Limoilou / Vieux-Québec
Enlarge map
|Not Available
|Establishment equipped for groups
|Establishment offering individual activities for youth, Individual clients
|Establishment offering group activities for youth
Pay outdoor car parking on site
Arab, English, French, Portuguese, Spanish


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2010 Matt's Memo
2010 Matt's MemoJanuary 6, 2010 - Joel
Mathews' success is predicated on our commitment to three steadfast core values: integrity, innovation and impact.
I remember once hearing that integrity can be determined by what people do when they don't know someone's watching. Here at Mathews, there are many extra steps in the process of making your bow that may be considered unnecessary by other manufactures. However, we will continue to do these processes because our testing ultimately shows superior results. It costs us more, but that's integrity.
At Mathews, we will always strive to achieve the extraordinary through the continuous improvement of people, process and product. This year is a great example of that. Mathews again turned the archery market on its head with the fastest, most efficient single- and dual-cam bows at 80 percent let-off on the market. The Mathews Reezen and McPherson Series Monster offer archers several options that are sure to fit their every need.
And for 2010, we launched a few bows earlier in the year, allowing for the models to receive proper attention. First, the Mathews Passion — a bow designed specifically for the female hunter. Gone are the days when lady archers have to adapt to other bows not made with their needs in mind. Female archers deserve something that not only fits them perfectly, but is stylish. After all, we want as many women out there to 'share the passion' for the outdoors as possible.
And of course, we continue to upgrade our industry-leading line of target bows — with one sure to fit your competitive edge. With the Mathews ProStaff continuing to win more ASA, IBO and NFAA World Titles than all other bow companies combined, we continue to make equipment that makes the probabilities of winning even greater. This new target bow will be debuted in fall of 2009, and www.mathewsinc.com will have all the details.
Perhaps the most important of these values to me is impact. What matters most to me is not how many bows Mathews sells each year, but rather how many people we impact in a way that effects there life for good, and in many cases, changes the literal course of there lives.
People often ask me how Mathews grew to where it is now. My response is that Mathews set out to be extraordinary from the beginning. I knew that you can never achieve extraordinary by being ordinary. From manufacturing the highest quality archery products, to the extraordinary people we have working in our customer service department; to our intensive research and development and our exceptional quality control — nothing we do at Mathews is ordinary.
Most importantly, the success of Mathews has allowed me and my wife, Sherry, to fuel our greatest passion — ministry and spreading the Good News to as many people as possible; as well as bringing clean water, food and shelter to people here and around the world who are in need. And whether we believe in the same things or not, we can agree there is a lot of need out there. It is very exciting for us to be able to play a part in impacting those lives.
More than 4.6 million kids have now picked up and shot a bow through the National Archery in the Schools Program since 2002. There is something amazing that happens when a child see's the flight of an arrow released from his own fingers for the first time. NASP continues to grow exponentially and we will continue to do whatever we can to see it reach its full potential. NASP has — and is — changing
lives one arrow at a time. If you would like to be a part of this wonderfull program please contact (608) 269-1779.
So first, I thank God for blessing me and allowing me this amazing opportunity. But I also thank you for owning a Mathews and sharing your love for the sport with others. We all have our own way of making an impact in this world, but because of your help and support, Mathews will continue to impact as many lives as we can.
Finally, I would like to thank you for helping Mathews become the largest bow manufacturer in the world. We will continue to provide you with the best products. That's our promise.
Have a safe and successful season, and God Bless.
— Matt McPherson
Founder and CEO of Mathews, Inc.


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If you love Bloc Party then you'll love this :)The iPhone case features the same design but with Bloc Party written down both sides too!
Other designs also available. Feel free to request an adjustment or a new design.
bloc party matt tong russel lissack kele kele okereke gordy moakes gordon moakes bloc party black heart colour rock band indie alternative hearts love
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Minimalist Blue Journal Skin by extraordi-maryWatch
©2011-2016 extraordi-mary
Minimalist Blue Journal SkinLIVE PREVIEW
I love the color blue, so I made this journal skin that's, well, all blue! I tried to keep the design clean and simple as well. I hope you enjoy!
Remember, only people with premium memberships can use journal skins!
Oh, and please if you use it, it lets me know that my work is appreciated!
To edit the links:
After installing the skin, click "Edit Skin" on the journal page. Once you're there, add this code to the Skin Header section, between the
 tags --
Text of the link here
To insert a title:
Add this code to your journal text --

Your title here

If you have any questions about the code, or if you notice glitches, please send me a note or leave a comment here!
Other Journal Skins
using X3
I am new to this whole journal skin thing, and would like to know exactly how to put this in?
This is a fab journal skin - it's just what I'm looking for!
When I post my first entry, I'll add a link back to here.
When I post my first entry, I'll add a link back to here.
YES! It was right this what I was looking for. Soft, light and simple!
i hope its ok if i use its really nice....
As you requested, I faved it to let you know I'm using it. It's pretty, it's simple, and it's just the thing I needed!
like simplicity !^^ i may use it if you dont mind ^^


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Josh's Journal: Entry 1Well, this is my first entry in my new journal. I figured I might as well start keeping one, given…recent events. I'm not quite sure what to right write in it, though…Guess I might as well catalogue what's been happening to me. I'll start with when I woke up.Josh's Journal: Entry 1 by llirbwerdnadivad
I found myself lying in a bed. It wasn't a very comfortable one, for that matter. I'm used to sleeping on the floor, though, so it wasn't unbearable. I'm a bit of a lazy bum, so I lay there for a while before opening my eyes.
I had recently been kidnapped, I remember that much…and since then, the friendliest people I've met were some tools in the back of a van that kept trying to kill me. …Ok, maybe the kidnappers weren't SO mean to me, after all. Anyway, looking around, I seemed to be in…well, my first guess would be a hospital of some sort, but why would kidnappers take me there? Kinda a public place…
Anyway, what clued me into in to
Josh's Journal: PrologueIt was a normal day outside. Josh had stayed home from school today due to being sick. The cold had seemed to come on out of nowhere. No warning signs, no slow onset of symptoms…He didn't even feel that bad, he just had a runny nose. A VERY runny nose. Josh had woken up that morning with most of his body covered in slimy mucus. While it hadn't been too hard to get off, it kept coming back. Josh had gone through two full boxes of tissues already, and he was nearing the end of his third one. With a sigh, he paused the video game he had been playing as he pulled out a few more to wipe his hands and face off again, as well as the video game controller.Josh's Journal: Prologue by llirbwerdnadivad
It was getting a bit ridiculous, how many tissues he was going through. There were several more boxes waiting for him, just in case, but he would rather not use up every tissue in the house just trying to keep things clean. It was a wonder how the mucus even got all over him in the first place; every time he checked, he ju
I support Ace Ventura, taking spears to the thighs long before Skryim came along with their arrows and their knees! www.youtube.com/watch?v=JEmklT…
Planning on filling the rest of this out soon...
dA Family:
Closest sis:
Male Sister:
Current Residence: I think I'm...oh no...where am I?!?!?!
Favourite genre of music: rock...I think...
Operating System: Windows XP, Mac, and Windows 7
MP3 player of choice: N/A
Shell of choice: ?
Skin of choice: I don't know...mine's kinda worn out, though...
Favourite cartoon character: Sonic the Hedgehog
Personal Quote: "I don't know"


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Liberals started advancing various themes, including that the Justices should not strike down all or part of ObamaCare because to do so would require a close vote. If the Justices strike down the law by a close vote, the theme continued, then the public would view the Court as "political" and the Court's reputation would be diminished for decades. (For Liberals, these same concerns do not apply if the Justices uphold ObamaCare by a close vote; in that circumstance, they will call the Justices "courageous.")
Here, apparently, is how the scenario of their publicity campaign is supposed to play out:
(It is mid-afternoon at the Supreme Court. The Justices have already held their post-oral argument conference and have cast their preliminary votes in the ObamaCare case. Justice Scalia is working at his desk. A beautiful Italian opera is playing softly in the background. His telephone rings. He answers it.)
"Nino. It's me, Ruth."
"Hey, Ruth. What's up?"
"Have you seen/heard the commentaries in/on [fill in whatever Liberal newspaper, blog, website, radio show, or television show you want]?"
"Well, they are saying we better uphold the Affordable Care Act or the public will think we are political and will not respect us anymore."
"Oh no! Let's get the others on the line!"
(Minutes later, the nine Justices are on a conference call. Justice Ginsburg repeats what she just told Justice Scalia. Immediately, those Justices, who initially had voted to invalidate ObamaCare, change their minds and decide to uphold it.)
Unfortunately for Liberals, despite the publicity campaign they are now waging, Justices are not swayed by public opinion, as Justice Thomas recently explained.
One of the main reasons is that Justices have lifetime appointments. Unless they commit an impeachable offense, they will remain a Justice until they retire or die. They do not have to worry about being re-elected. They are not concerned that their salary will be based on how they rule in a case. They do not have to jockey for position so they can get a better judge job—they already sit on the highest court in the land. In short, their lifetime appointments insulate them from outside pressure. They rule on cases based on their interpretations of the Constitution, even if the public disagrees with those interpretations.
By now, the Justices have rendered their preliminary votes in the case. These votes are based on the arguments in the briefs the parties and the "friends-of-the-court" have filed, by the oral argument presentations, by the Justices' discussions, and, most importantly, by the Constitution.
Granted, those preliminary votes may change. But, any changes will not be caused by the views of an outside commentator. At this point, any vote changes will occur based on the strength of the Constitutional interpretations laid out in the various opinions the Justices will be circulating among themselves.
That is how the process works—just as it should. We will know the outcome of that process by June.
Rush Limbaugh defends Rubio's debate answer: He's absolutely right that Obama knows what he's doing | Allahpundit
Time for Team Hillary to break out the gender card for young liberal women who prefer Sanders | Allahpundit


text:
Reborn Lara 8 by TerribilusWatch
©2013-2016 Terribilus
I actually thought it was concept art from the game! It's so perfect, job well done
Thank you very much Madi!!
Stunning work!
I know i'am so late at this comment....:3....but i do say this is awesome............... i do say in my book.....but as long as it was funny doing it. Its all that matters pal....i know i ain't epic at stuff or anything...but i love when i see epic ppl at there best. But thing i really love about this is that she very young at age on this game...which is great with meh...but i still love the old looking Lara myself....to say. But glad Tomb Raider is still around alive & kicking a bit.......tho you bring the best of both worlds...its sorta like she young & old at the same time. To break it down: She has on her younger clothes...but her body and face looks so older than the model that was used for the game, if that helps out.....
Imma use this for something kewl....i think this is going to be my NEW phone wallpaper....i swear....you're Terribilus at this stuff pal....just Terribilus........keep up great-ness.....i'll be back to collect just about everything you made........
Thank you so much Darell! You made my day!!
Glad to help out after you help me out to find this so awe-some-sauce pic of art you created....* i ment to say fun and not funny...typo*............. Just wanted to clear that up a bit.......and how could i let something epic as this to past my . eyes....i need to call a mistress to spank my hyde for that one........im just not to collect this....im losing my mind & love for Lara...can't be happen.
Other than that....you did a hell of a job........even tho i still like this as a top ....even if the other was more with exploding barrels or whateva....its still a 2nd place win....or still Top 5. for this wonderful artwork after all.......
this is just amazing!! I guess it was hard work,wasn't it?
This is so amazing! You have captured her personality and skill perfectly!
Wow, you've captured her perfectly
that's hard work
This is beautiful!
I LOVE it!
not sure why this didn't place given what they gave awards too, well done! Perhaps it wasn't as action packed as they'd wanted.
Awesome artwork, I like her pose and the lighting
Много добра серия, ман
What do you mean?
Well, examine the image I linked, which is the official Art, and compare the face to this art here.
Hmm...you might be right.
And if you weren't fucking stupid you could make out the fine differences in that picture. There are a lot of differences.
This os good - absolutly fantastic!
I think this one captures everything there is in the new survivalist Lara, awesome! Indeed, reborn!!!
YES!! This is awesome!!
Голяма работа че лицето е гледано. Желая ти успех, адаш.
Freaking amazing, but the pose... just facepalm.
The asset page called, it wants it's face back.
That is fantastic!
I love this one so so so much!!! It's amazing!! I hope you win! <3
It's really gritty and earthy.
Personnaly I think you will be the winner, really. I could Bet it.
Thank you very much Jeremy! I don't think I deserve it - there's some realy great submissions. The judges will decide. Thanks again!


text:
Founder & CEO, IndiaMART
Dinesh Agarwal is the founder and CEO of IndiaMART.com, India's largest online marketplace connecting Indian suppliers with domestic and international buyers. Founded in 1996, Dinesh is credited with leading IndiaMART.com through a decade and a half with an unblemished record of being profitable from day one – a feat no other online company in India has been able to emulate. IndiaMART is today arguably one among the world's top ten marketplaces, as has been corroborated by a host of credible market surveys. Under Dinesh's dynamic and visionary leadership, IndiaMART today is a 2800 strong talented pool of human resource with pan-India presence covering over 100 cities. It's stellar credentials, robust business model and Dinesh's commitment towards the MSME sector has invited prestigious investors like the Times of India Group and Intel Capital into its fold for further expansion plans. A vigorous advocate of Indian SMEs, he has spearheaded several path breaking ideas to promote Indian SMEs globally. His contribution to Indian businesses is widely acknowledged by the media.
Prior to pursuing his entrepreneurial instincts, this Computer Engineer from HBTI, Kanpur has honed his technical skills working for industry leaders such as HCL Technologies (America), Center for Development of Telematics (C-Dot) and CMC Limited before returning to India. He has an extensive experience spanning over 16 years in the field of Internet, Networking & Systems Development and Consulting.
Co-Founder & Director, IndiaMART
Brijesh Agrawal is the Co-Founder & Director, IndiaMART.com. Being a part of the core management team, Brijesh has been the brainchild behind the creation of a plethora of innovative products of IndiaMART. Since inception, Brijesh has been providing eclectic strategies appertaining to Sales, Marketing, Operations and Human Resources. With an paranomic nine years of experience in the B2B world, he has provided the brainwave to many a professionals who are now playing the leadership roles in their respective fields. A management graduate from the University of Lucknow and an MBA from National Institute of Integrated Learning and Management (NIILM), Brijesh started his career as a Supply Chain Consultant at Miebach Logistics GmbH, Bangalore.
An astute businessman, Brijesh's biggest strength is his entrepreneurial style of functioning and the ability to forge strong relationships with people. Mingling easily across levels and industries, he is acknowledged as a complete people's person, who likes to leads from the front.
Managing Director, Mahendra & Ardneham Consulting (P) Ltd.
He is the Managing Director of a successful Board Advisory Consulting company – Mahendra & Ardneham Consulting (P) Ltd. He advises companies on building cohesive & high performing boards and aligning corporate strategy with sustainable business. He has 34 years of valuable experience in large Indian and multinational companies and in management consulting.
Mahendra has an experience of sitting on the Boards of companies as Independent Director, from a variety of sectors like Financial Services, Information Technology, Capital Goods, Exposition, Telecommunications & Pharmaceutical companies. He has been member of advisory board for Asia, for Stern Stewart & Company (The EVA Company of USA).
Mahendra is an MBA with specialisation in Finance and holds a bachelors degree in science (B.Sc.) with Physics, Chemistry and Biology. He has done a course from Wharton Business School, University of Pennsylvania, USA,. for board of Directors on 'Governing the Corporation: Global Perspectives in the Indian Context'. Mahendra is consultant to World Bank – IFC, and also holds a certificate by World Bank, IFC, Global Corporate Governance Forum USA, as Trainer for Board of Directors.
Founder, Super Angels of India
Rajesh is the Founder of Super Angels of India. He has a vast experience in entertainment, media and communication sector which also includes his last association with Reliance Entertainment Private Limited as president for seven years. Before Reliance Entertainment, he was associated with BCCL for 14 years in different leadership roles. He had built Indiatimes.com from a start-up venture. During his 14 years stint with BCCL, he created successful businesses across several new areas, including publishing, Radio, TV, retailing, internet, e-commerce, travel and mobile VAS. He is based in Mumbai.
He holds Bachelor's degree in Electronic Engineering from Delhi University, and Master's degree in Management from Mumbai University. He has also done a fellowship in 'Globalisation and Leadership' from the London School of Economics and Social Sciences.
Former Managing Director (India) – Leadership and Talent Consulting, Korn/Ferry International
Dhruv is a former Managing Director, Leadership & Talent Consulting, at Korn/Ferry International (India). He has been helping the organizations manage change, coach senior management, build high performance cultures, restructure and conduct post-merger integration.
Dhruv has an extensive and versatile industry experience of over 36 years in Management Consulting, Financial Services, Corporate Finance, Manufacturing, Oil and Gas, Chemicals, International Trade and Marketing. Prior to joining Korn/Ferry, Dhruv served as a Director with Helion Ventures guiding investment teams to evaluate potential investee companies from a people perspective and working with the portfolio companies on their leadership and talent management strategies and systems. During his expansive career, Dhruv has worked with several esteemed organizations. He was the CEO and full-time director on the Board of DCM Financial Services, CFO of DCM Toyota and held several senior positions at Escorts, HCL and Amar Dye Chem.
Dhruv is an MBA from Indian Institute of Management, Ahmedabad.
Lizzie Chapman
Executive Director, DBS Digital
Lizzie is currently the Executive Director with DBS, and is focused on launching a new digital bank in India. Her passion to use technology to disrupt traditional financial services made her move to Mumbai in 2011 to start the Indian operations of Wonga.com – one of the world's most innovative financial services companies.
Lizzie started her career with Goldman Sachs in equity research and asset management. She then became an investor for The Wellcome Trust, one of the world's largest endowments, as a founding member of the direct private investment team, where she focused on India and financial services.
Lizzie loves design and travel, and combined these passions in 2013 to launch Abode Bombay, the city's first luxury boutique hotel. She is actively involved in the early stage startup scene, and serves as an advisor to a number of companies including the digital SME finance provider, Capital Float.
Lizzie is an Investment Committee member of the early stage fund – India Quotient, a Mentor with Global Super Angels, and also a TiE Charterholder.
Lizzie is an avid runner and has competed in marathons around the world, as well as being a podium finisher and pacer in the Mumbai marathon.


text:
Vegeris, Sandra and Vowden, Kim and Bertram, Christine and Davidson, Rosemary and Durante, Lucia and Hudson, Maria and Husain, Fatima and MacKinnon, Karen and Smeaton, Deborah (2010) Jobseekers Regime and Flexible New Deal evaluation: a report on qualitative research findings. DWP Research Report, 706 . A report of research carried out by Policy Studies Institute on behalf of the Department for Work and Pensions, London. ISBN 9781847128737Full text not available from this repository.
Official URL: http://research.dwp.gov.uk/asd/asd5/rports2009-201...
|Item Type:
|University of Westminster > Architecture and the Built Environment > Policy Studies Institute (PSI) (No longer in use)
|Depositing User:
|Miss Nina Watts
|Date Deposited:
|15 Jun 2011 14:17
|Last Modified:
|17 Jun 2011 10:56
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Select Local Merchants
The Float PlaceRead MoreSignature Service: Floatation Therapy, Stimulus Reduction Established: 2013 Reservations/Appointments: Required Handicap Accessible: No Parking: Parking lot Minimum Age Requirement: 18 About The Float Place At The Float Place, regular folks can do in an hour what it has taken gurus of all stripe decades to achieve—tune out external distractions. Inside the sensory deprivation tank , clients ease into a hygienic saline solution heated to their exact body temperature. The solution keeps them buoyant, creating the feeling of weightlessness while the pod keeps out noise, light, and demons. In addition to creating a deep sense of relaxation, people report all manner of benefits, including relief from insomnia, headaches, and even addiction.UnknownFarmingville, NY US
Ava Nail SpaRead MoreNeed to de-stress? Head on over to Ava Nail Spa in Farmingville and enjoy a full spa experience. Clear up your skin with a relaxing and rejuvenating facial. For clear and hydrated skin, try a skin care treatment such as a body wrap and microdermabrasion. Avoid the hassle of painting your own nails and head to this spa for a quick and professional nail care treatment. Looking for a relaxing and affordable massage? Look no further than this spa. Remove unwanted hair with Ava Nail Spa's painless hair removal services. Need a color refresh or a fresh cut? Head to this spa for a new, upgraded look. This spa accepts walk-ins, allowing you to quickly take care of all your beauty needs. Sometimes you just have to treat yourself. With Ava Nail Spa's pricy and relaxing spa treatments, you can do just that. For a quick and easy payment solution at Ava Nail Spa, pay by major credit card. Visit Ava Nail Spa today and let your inner beauty shine through.838 Horseblock RoadFarmingville, NY US
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Angel Tips Nail SpaRead MoreTreat yourself to a relaxing nail care service from Angel Tips Nail Spa in Farmingville and reap the benefits. Colored or styled, a new hairstyle from this salon will leave you feeling refreshed. This establishment offers a wide array of nails services, such as no-chip gel manicures, pedicures, manicures, and nail art, to keep your nails looking clean and stylish. When you chip a nail or polish, call upon Angel Tips Nail Spa for all of your quick and convenient nail fixes.411 Horseblock RoadFarmingville, NY US


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I don't think think I learned anything new about multilingualism. In that respect, it was a waste of time of money. There was a lot of fluffy "write letters to relative" and that sort of stuff.
However, I will say that I personally enjoy reading the "How to Raise your Child" types of books, so I did enjoy reading it. I just don't think I learned anything. It was all common sense.


text:
Isn't it a fun time of the year? Especially if you are a fan of a team with a chance at the post season. To be in the buyers' market with trades, is so much fun. So it is for the Cincinnati Reds. They are reportedly involved in several trade options throughout the league. A week ago MLB Rumors noted that Cole Hamels (Philadelphia Phillies) was a possible trade for the Reds. It has come to light from ESPN's Buster Olney that another Phillie was a very possible pick up for the Reds. That is none other than Juan Pierre (Slappy).
While a Reds' trade to get Hamels would be a great acquisition for the Reds, there is a big chance that the Reds would not be able to sign him to an extension, and, consequently, would only rent him for the 2012 season. As for Pierre, that is a more logical and possible trade for the Cincinnati Reds, as MLB Rumors suggests.
Pierre would bring to the Reds a batting average of .307 and an on-base percentage of .344 to that lead-off spot. That would allow the Reds to move Zack Cozart to second in the line-up and move Drew Stubbs out. Pierre still has speed as the 20 stolen bases suggest. The biggest benefit would be in strike outs. In 241 at bats, Pierre has only stuck out 13 times. That is big improvement from the present strike out factory that is Stubbs.
In addition, the Reds would be adding a much needed left handed bat to there heavily right handed hitting line-up. Not to mention the .304 batting average in his post season career. Something the Reds will need down the stretch.
The Phillies have declined that they are in the sellers' market. However, as the losses mount – they are on a 4 game losing streak and losers of 9 of the last 10 games, things may change quickly as the trade deadline approaches. When that does happen, the Reds would be foolish to not be in line for Pierre's services.
Continue to watch for MLB Rumors for future rumors floating around the baseball world.


text:
Are you Zhi-Yong Wang?Claim your profile
Publications (7)2.98 Total impact
Article: Accumulation of CD208(+) Mature Dendritic Cells Does Not Correlate With Survival Time in Oral Squamous Cell Carcinoma Patients[Show abstract] [Hide abstract]
ABSTRACT: Purpose We sought to investigate the distribution and clinical outcomes of tumor-infiltrating CD208+ mature dendritic cells (mDCs) in OSCC patients. Materials and methods Using immunohistochemical analysis, the distribution of CD208+ mDCs in adjacent non-neoplastic tissues (NT) and tumor tissue including tumor stroma (TS) and tumor nest (TN) of 79 OSCC patients were evaluated. The analysis was quantitative, and the number of positive cells was counted in 5 microscopic high-power fields (400×). At gene expression level, CD208 expression was also assessed by q-PCR. Kaplan Meier analyses were used to analyze the prognostic value of tumor infiltrating CD208+ mDCs. Results The number of tumor infiltrating CD208+ mDCs was higher in TS and TN than in NT (P<0.0001) and the number of CD208+ mDCs in TS was higher in lymph node positive OSCC patients (P<0.05). At gene expression level, CD208 was also upregulated in lymph node positive patients (P<0.05). The number of infiltrating CD208+ mDCs was not associated with patient's survival time. Conclusions The number of tumor infiltrating CD208+ mDCs in TS was higher in lymph node positive OSCC patients, but the accumulation of CD208+ mDCs does not correlate with survival time in oral squamous cell carcinoma patients.
Article: Upregulation of a potential prognostic biomarker, miR-155, enhances cell proliferation in patients with oral squamous cell carcinoma[Show abstract] [Hide abstract]
ABSTRACT: We sought to investigate the role and diagnostic value of microRNA 155 (miR-155) in OSCC patients. Using real-time quantitative polymerase chain reaction analysis, miR-155 expression levels were assessed in OSCC cell lines and a cancerous HB cell line. The correlation between miR-155 expression level and clinical parameters was analyzed in 46 patients with OSCC. In addition, the effects of miR-155 on OSCC cell proliferation were evaluated by modulating its expression using an miR-155 mimic and antisense miR-155. Significant upregulation of miR-155 was found in OSCC cell lines and in tissues of patients with OSCC. The receiver operator characteristic analysis indicated fair-to-good predictability. Overexpression of miR-155 correlated with the histologic grade (P = .033), and the upregulation of miR-155 enhanced OSCC cell proliferation. In OSSC, upregulation of miR-155 correlated with the histologic grade and can be used as a potential prognostic biomarker.
Article: Effect of siRNA-mediated downregulation of VEGF in Tca8113 cells on the activity of monocyte-derived dendritic cells[Show abstract] [Hide abstract]
ABSTRACT: Vascular endothelial growth factor (VEGF) is a tumor angiogenesis factor that is important in immune regulation. In our previous study, we found that VEGF expression in the peripheral blood and neoplasm nest from patients with oral squamous cell carcinoma (OSCC) was positively correlated with the course of disease, while an inverse correlation between VEGF expression and dendritic cells (DCs) was identified in the peripheral blood. Therefore, in the present study, we investigated whether inhibition of human VEGF in the human tongue carcinoma cell line Tca8113 had effects on the activity of monocyte-derived DCs. We knocked down the expression of human VEGF in Tca8113 cells using the small interfering RNA (siRNA) technique. Tca8113 cells pre-transfected with siRNA targeting VEGF were co-cultured with monocyte‑derived immature and mature DCs. Cell proliferation was evaluated by a WST-8 assay. Cell apoptosis, cell cycle and cell phenotypes were determined by flow cytometry. The data revealed that downregulation of the human VEGF significantly inhibited the proliferation of Tca8113 cells and increased apoptosis. Inhibition of human VEGF arrested the cell cycle of Tca8113 cells at the G0/G1 phase. Our results showed that the co-culture of DCs with Tca8113 cells markedly inhibited the expression of the mature markers of DCs including HLA-DR, CD80, CD86, CD40 and CD1a, as well as the immature marker CD83, while inhibition of human VEGF in Tca8113 cells significantly reversed these effects. Therefore, human VEGF in Tca8113 cells may not only regulate the cell proliferation and apoptosis of oral squamous cell carcinoma cells, but may also inhibit DC maturation.
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ABSTRACT: To assess the clinical features and therapeutic efficacy of anterolateral thigh (ALT) flaps for the intraoral defects reconstruction. The clinicopathologic data of 67 cases with oral tumors were obtained from School of Stomatology, Nanjing University Medical Center from Dec. 2008 to Dec. 2010. All the patients underwent the simultaneous tumor resection and intraoral defects reconstruction with free anterolateral thigh flaps. The defects included the tongue, buccal, gingival, mouth floor, and so on. The descending branch of lateral femoral circumflex artery was anastomosed to the external maxillary artery or superior thyroid artery; the vein was anastomosed to the common facial vein or external jugular vein. The flaps were divided into three types: musculocutaneous ALT flap, fasciocutaneous ALT flap and thinned ALT flap. There were 38 male patients and 29 female. The anterolateral thigh flaps included 35 musculocutaneous flaps, 17 fasciocutaneous flaps and 15 thinned flaps. The success rate was 98.5% (66/67). Partial necrosis happened in one case with diabete, which healed after debridement and dressing. 1 flap was totally necrosis. Double venous anastomosis was performed in 41 flaps, and one venous anastomosis was performed in 26 flaps. 8 patients required operative exploration in the perioperative period including 6 flaps with thrombotic events (5 flaps were complete survival after the salvages, and 1 flap was failure) , 1 flap with hematoma, and 1 flap with twisting of perforator. The follow-up period ranged from 2 to 24 months( mean, 8.7 months). The result was satisfied. The donor sites were closed directly in all patients, and the wounds healed uneventfully. The free anterolateral thigh flap is an ideal soft tissue flap for the intraoral defects reconstruction with good functional result at recipient area and less morbidity at the donor site.
Article: [Research on the correlation of vascular endothelial growth factor and dendritic cell in patients with oral squamous cell carcinoma].[Show abstract] [Hide abstract]
ABSTRACT: To investigate the effect of vascular endothelial growth factor (VEGF) on the differentiation, formation and function of the dendritic cell (DC) in peripheral blood of patients with oral squamous cell carcinoma (OSCC). Flow cytometry was used to detect the number of DC in peripheral blood of 81 patients with OSCC, and ELISA applied to test serum VEGF concentration the OSCC patients, and immunohistochemistry used to observe the expression of VEGF in primary foci of 57 patients with OSCC. DC from CD-14 peripheral blood mononuclear cells were cultured with VEGF(165) in vitro to investigate the cytokine's effect on DC. In comparison with controls [(325.70 +/- 117.54) ng/L], the level of serum VEGF [(764.33 +/- 263.64) ng/L] was significantly increased (P < 0.01) and the DC numbers was significantly decreased (P < 0.01) in patients with OSCC. There was a negative correlation between serum VEGF concentration and the level of DC (P < 0.01). The expression of VEGF in primary focus was positively correlated with serum VEGF concentration, but was negatively correlated with the level of peripheral blood DC (P < 0.01). DC cultured in vitro with VEGF(165) decreased the expression of CD-1a, CD-40, CD-80, CD-86, CD-83, HLA-DR, and revealed a lower ability of stimulating T lymphocyte proliferation but a higher ability of uptake, compared to controls. The overexpressed VEGF in patients with OSCC might be one of the important reasons for blocking the differentiation and maturation of DC.
Article: [Inhibitory effect of dendritic cell vaccine on the growth of implanted tongue squamous cell carcinoma tumors in nude mice].[Show abstract] [Hide abstract]
ABSTRACT: To investigate the inhibitory effect of dendritic cells (DCs) on the growth of the implanted tongue squamous cell carcinoma (SCC) tumors in nude mice. Being induced from human peripheral blood monocytes (PBMCs) with rhGM-CSF, rhIL-4 and rhTNF-alpha, DCs were pulsed by Tca8113 cells lysates. Those DCs and T lymphocytes were co-cultured to induce specific cytotoxic T lymphocytes (CTLs). Immunotherapy was then performed after those DCs and CTLs were implanted into the tumor-bearing nude mice. DCs were induced from PBMCs with multiple cytokines. Compared with the control groups, the growth of tumors was significantly inhibited in the group that had been implanted with DCs and CTLs, and tumor doubling time also increased markedly (P < 0.05). DCs function normally after being induced from human PBMCs with multiple cytokines; DCs pulsed with tumor cell lysates and CTLs co-cultured with those DCs have a significant anti-tumor immune activity in nude mice.
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ABSTRACT: To elucidate the functional status of dendritic cells (DC) in the tissue of oral squamous cell carcinoma by analyzing characteristic phenotype of them. 34 specimens from oral squamous cell carcinoma cases primarily treated with surgery were selected as test group. In addition, 30 specimens of normal mucosa from oral mucocele cases were used as control. Distribution of DC expressing CD1a+, HLA-DR+ and CD83+ in tumor tissue and normal mucous membrane was observed by immunohistochemistry. The number of DC expressing the antigens, which represented the density of DC infiltrating into tissue, was counted by microscope. The density of DC and the rate of DC expressing HLA-DR in oral carcinoma group and control were statistically compared. There was no CD83+ DC in all cases, but CD1a+ DC was found in all samples. The density of CD1a+ DC in tumor tissue was significantly lower than that in normal mucous membrane (P < 0.05). HLA-DR antigen expressed on the surface of DC in tumoral epithelium of 27-case carcinoma specimens and in normal mucous epithelium of 23 cases. The rate of HLA-DR positive expression of TIDC had no statistic significance between the two groups. The lower density of DC infiltrating in tumor tissue might reflect the microenviromental immunodeficiency of hosts with oral squamous cell carcinoma, and the functional mature of DC might be inhibited by the immunosuppressive action of oral squamous cell carcinoma.
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Nanjing University
Nan-ching, Jiangsu Sheng, China
- School of Medicine


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Noteworthy and not-so-noteworthy holiday albums
Published: Thursday, December 10, 2009 at 6:30 a.m.
Last Modified: Tuesday, December 8, 2009 at 5:56 p.m.
Christmas is for giving, and so many singers worth their weight - and some who arent roll out albums for the holidays. But are they deserving of a big, red bow - or worth a bunch of switches in a stocking?
Heres a look at some of the seasons highest-profile albums from staff and elves.
Christmas in the Heart
Bob Dylan
According to some reports, Bob Dylan was as angry as Santa with a broken sled after hearing some critics thought his first Christmas album was made as a joke.
But thats not to say the Great Ones tongue isnt a little firmly in his cheek (next to those ragged vocal cords) with some of this album, a platter of 12 covers that seems directly inspired by his satellite-radio show, Theme Time Radio Hour, which explores the wellspring of everything from early R&B hits and Western swing to big band and novelty songs.
In that context, Dylans album with retro-for-fun backing vocals and instrumentation can be considered a success - especially with such off-beat selections as Christmas Blues, the 1953 Dean Martin hit that becomes boozy-woozy fun for Dylan; Christmas Island, which pays homage to the 1946 Guy Lombardo/Andrews Sisters single with similar backing vocals; and especially Must Be Santa, a polka-on-steroids number with Dylan hilariously warbling ho, ho, ho!
It must be said, though, that on a few tracks, Dylans vocals sound like Elmer Fudd meets Donald Duck (Do You Hear What I Hear) or Tom Waits punch-drunk on helium (Hark the Herald Angels Sing) with some lines delivered painful enough to make Christmas in the Heart for the Dylan faithful only.
- Bill Dean
Ultimate Christmas Collection
Jackson 5
If youre looking for tunes to rock around the Christmas tree to, the first half of the new Jackson 5 Ultimate Christmas Collection will meet your expectations, while the second half will fall a little short.
The new collection is essentially the 1970 Jackson 5 Christmas Album re-issued and remastered with six bonus tracks, seasons greetings from Michael and his brothers, and the re-release of Little Christmas Tree from the 1973 A Motown Christmas album.
The first 11 songs, including Santa Claus Is Comin To Town and Up On The House Top will rock your stockings off with groovy, soulful J5 harmonies, but the bonus tracks are a waste of time.
The Up On The Housetop, Rudolph The Red-Nosed Reindeer, and Someday At Christmas re-edits and remixes offer nothing new or exciting. Even the a-cappella version of Give Love On Christmas Day doesnt warm your heart like the original song. One also would think that the J5 Christmas Medley at the end of the album would include something different, but it is just parts of five previous songs blended together without any other type of arranging. The only redeeming bonuses are the Jacksons greetings and Michaels Little Christmas Tree.
When it comes to Christmas tunes, the original 1970 album reigns supreme. Anything more just becomes holiday-party background music.
- Ali Ochal
If on a Winters Night
Will someone PLEASE pry that lute from Stings hands? Sure, his 2006 collection of Elizabethan music, Songs from the Labyrinth, topped classical charts. And it was an interesting voyage.
Yet the former Police chiefs recent offering, If on a Winters Night, rings of seasonally solemn Charlie Brown.
Sting contends his new disc is not a Christmas CD, but rather a winter CD, and it is as somber as a dreary, overcast January. It dips into 14th century traditional songs as well as 20th century poems. It is accented with a harp, cello, melodeon, lute and northumbrian smallpipes (go to Google, I guess).
As Sting himself said, its not entirely a happy record, and, certainly, it is not a launchpad for the holiday spirit. Put it in a shuffle mix with merry holiday CDs, and its a gear-clogging wrench.
That said, though, there are moments of absolute beauty on this disc. This is Sting, after all. Highlights include the ancient hoedown Soul Cake, which weaves in God Rest Ye Merry Gentlemen, and the oh-so-sweet Cherry Tree Carol and Lullaby for an Anxious Child.
Much of the disc, however, is, as they say, interesting; an intellectual diversion you know you are supposed to adore. But, in reality, you yearn for Roxanne peppered with Rudolph.
Sting, your bass guitar misses you.
- Dave Schlenker
A Christmas Gift For You from Phil Spector
Various artists
Over the decades, plenty of famous pop groups and solo artists have churned out lackluster to straight-out bad Christmas albums.
This one, a reissue of 1963s A Christmas Gift for You from Philles Records, is not one of them. Producer-extraordinaire Phil Spector and his trio of classic girl groups - the Crystals, the Ronettes and Darlene Love - reinvent traditional holiday tunes such as Frosty the Snowman and Winter Wonderland backed by Spectors trademark wall of sound, a mix of guitar, horns, strings and driving drums. My personal favorite is an original tune that Spector co-wrote: Darlene Loves Christmas (Baby Please Come Home).
Proof of the albums greatness: That track and The Ronettes Frosty the Snowman are both part of the soundtrack to Martin Scorseses mob classic, Goodfellas.
- Chris Curry
Gold and Green
After five years of bringing the green to Nashville, country-poppers Sugarland celebrate the occasion with Gold and Green, an aptly named, first-time Christmas album that will likely keep the green coming with its offering of mostly country gold.
The albums 10 songs split right down the Santa-sleigh line with five classics and five originals that should please fans and might even score a perennial holiday favorite on the airwaves.
A zippy Winter Wonderland with Jennifer Nettles on vocals manages to sound both breezily contemporary and neo-honky-tonk at the same time, while Nuttin For Christmas offers good-time fun like egg nog with an extra kick.
And Kristian Bush sings Holly Jolly Christmas almost well enough to supplant memories of Burl Ives.
Of the new songs, the warm ballad Little Wood Guitar might have the best chance of becoming a Christmastime staple. And while Nettles belts out a bluesy Coming Home that sounds about as Christmasy as a leprechaun, its nevertheless memorable. And Maybe Baby (New Years Day) keeps the duos knack for coming up with new songs that sound like instant classics intact.
Bill Dean
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Stop 2 million tons of toxic waste from being dumped on the Rahway River!
A well-heeled developer is proposing to bring millions of tons of highly contaminated soil to a site directly along the Rahway River and adjacent to the Arthur Kill. In fact, they plan to dump more than 2 million tons of more heavily contaminated waste on top of environmentally sensitive area along the Rahway River. After empty promises of a project that would restore this environmentally sensitive area, their application will turn the Rahway River and Arthur Kill into a giant toxic dumping ground and label it as a "Soil Class B Recycling" facility. Their permit applications are full of misleading data, misapplied permits, and environmental risks for central New Jersey residents and the environment. Meanwhile, the developers will be making tens of millions of dollars in profit. Similar projects in South Jersey have turned into incredibly troubling environmental disasters leading to violations, false engineering, and destruction of sensitive wetland areas. These projects are a waste of taxpayers' money and externalize the risk to you and I while making this relatively unknown company ultra-wealthy. They appear to be politically strong-arming the New Jersey Department of Environmental Protection (NJDEP) by hiring politically connected law firms in order to get their plans and applications approved without stipulations.
Please sign the petition below and send a message that our estuaries are no longer toxic waste landfills. Stop these polluters from further destroying our waterways and ecosystems that are finally starting to rebound from the past abuse during the industrial revolution. Tell NJDEP to reject Soil Safe's permit applications for a so called "remediation".
Edison Wetlands Association started this petition with a single signature, and now has 1,192 supporters. Start a petition today to change something you care about.
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You are to be pardoned if you approach the nondescript brick SoMa building that houses Una Pizza Napoletana, walk through the door (plate glass, like the rest of the façade), and have the brief sensation of arriving at an art gallery between installations. Or perhaps the high-ceilinged, white-walled cube with a turquoise-tiled conical shape rising from the center seems more like a museum? No. It's a pizzeria, home to tattooed chef and former New Yorker Anthony Mangieri, and the tiled shrine is the pizza oven. Pizza is the sole objet d'art: that's it, nothing more, no sides, substitutions, condiments, nada. The drill isn't quite as severe as on Seinfeld's "Soup Nazi" episode, but it's still a singular and tasty experience.
210 11th St., SF. (415) 861-3444, www.unapizza.com/sf
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Peter Masterson (II)
Peter Masterson was born as Peter Carlos Masterson. He is known for his work on The Devil's Advocate (1997), Stepmom (1998) and Mona Lisa Smile (2003). He has been married to Jennifer Tost since May 8, 2003. See full bio »
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We know you're anxious to learn all about Apple's upcoming tablet, and you will, but not until tomorrow morning when Steve Jobs plans to announce "a major new product that we're really excited about." So even though it might be pretty poor timing on HP's part, there's a new video making the rounds on the Web in which Phil McKinney, CTO of HP's Personal Systems Group, answers a few questions about his company's upcoming HP Slate.
Most of the video deals with the Slate's background and history, and we learn that HP first began working the tablet concept five years ago "around the concept of an e-reader platform." Based in part on user feedback requesting rich media content, the initial concept evolved into the Slate, McKinney says.
"What we predict is that users are looking for that consolidated device, that one device that they can use really as their ultimate content consumption experience," McKinney explains. "And also we saw this gap in the marketplace north of kind of what a smartphone was and smaller than the netbook and notebook. They wanted something thin and light, but again, allowing them to have that rich media experience."
According to McKinney, the Slate will be every bit as good as the current e-book readers on the market, but also capable of a whole lot more. What he didn't say, however, is what kind of hardware you can expect, though he did describe 2010 as the optimal year for the Slate because of a "perfect storm of innovation" consisting of a convergence of "low cost, low power processors, Win 7 with an operating system that is touch aware, the ability to create these kind of platforms with new kinds of touch technologies and hit that price point."