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Publications (58)400.89 Total impact
Article: Thrombotic microangiopathy in metastatic melanoma patients treated with adoptive cell therapy and total body irradiation[Show abstract] [Hide abstract]
ABSTRACT: Thrombotic microangiopathy (TMA) is a complication that developed in some patients receiving 12 Gy total body irradiation (TBI) in addition to lymphodepleting preparative chemotherapy prior to infusion of autologous tumor-infiltrating lymphocytes (TIL) with high-dose aldesleukin (IL-2). This article describes the incidence, presentation, and course of radiation-associated TMA. The data for patients with metastatic melanoma who received ACT with TIL plus aldesleukin following myeloablative chemotherapy and 12-Gy TBI was examined, in order to look at patient characteristics and the natural history of TMA. The median time to presentation was approximately 8 months after completing TBI. The estimated cumulative incidence of TMA was 31.2% (median follow-up of 24 months). Noninvasive criteria for diagnosis included newly elevated creatinine levels, new-onset hypertension, new-onset anemia, microscopic hematuria, thrombocytopenia, low haptoglobin, and elevated lactate dehydrogenase values. Once diagnosed, patients were managed with control of their hypertension with multiple agents and supportive red blood cell transfusions. TMA typically stabilized or improved and no patient progressed to dialysis. TMA was associated with a higher probability of an antitumor response. TMA occurs in approximately a third of patients treated with a lymphodepleting preparative chemotherapy regimen with TBI prior to autologous T cell therapy. The disease has a variable natural history, however, no patient developed end-stage renal failure. Successful management with supportive care and aggressive hypertension control is vital to the safe application of a systemic therapy that has shown curative potential for patients with disseminated melanoma. Cancer 2014. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.
Article: Human Melanoma Metastases Demonstrate Non-Stochastic Site-Specific Antigen Heterogeneity that Correlates with T Cell Infiltration.[Show abstract] [Hide abstract]
ABSTRACT: Metastasis heterogeneity presents a significant obstacle to the development of targeted cancer therapeutics. In this study, we sought to establish from a large series of human melanoma metastases whether there exists a determined pattern in tumor cellular heterogeneity that may guide the development of future targeted immunotherapies. From a cohort of 1514 patients with metastatic melanoma, biopsies were procured over a 17 year period from 3086 metastatic tumors involving various anatomic sites. To allow specific tumor cell profiling, we utilized established immunohistochemical methods to perform semi-quantitative assessment for a panel of prototypic melanocyte differentiation antigens (MDAs) including gp100, MART-1, and tyrosinase (TYR). To gain insight into the endogenous host immune response against these tumors, we further characterized tumor cell expression of MHC I and MHC II and, also, the concomitant CD4+ and CD8+ T cell infiltrate. Tumor cell profiling for MDA expression demonstrated an anatomic site-specific pattern of antigen expression that was highest in brain, intermediate in soft tissues/lymph nodes, and lowest in visceral metastases. Hierarchical clustering analysis supported that melanoma metastases have a phylogenetically determined, rather than a stochastic, pattern of antigen expression that varies by anatomic site. Further, TYR expression was more frequently lost in metastatic sites outside of the brain and was uniquely correlated with both endogenous CD8+ and CD4+ T cell infiltrate. Site-specific antigen heterogeneity represents a novel attribute for human melanoma metastases that should be considered in future therapy development and when assessing the responsiveness to antigen specific immunotherapies.
Article: Randomized Selection Design Trial Evaluating CD8(+)-Enriched Versus Unselected Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy for Patients With Melanoma[Show abstract] [Hide abstract]
ABSTRACT: PURPOSEAdoptive cell therapy (ACT) with autologous tumor-infiltrating lymphocytes (TILs) and high-dose interleukin-2 (IL-2) administered to lymphodepleted patients with melanoma can cause durable tumor regressions. The optimal TIL product for ACT is unknown. PATIENTS AND METHODS Patients with metastatic melanoma were prospectively assigned to receive unselected young TILs versus CD8(+)-enriched TILs. All patients received lymphodepleting chemotherapy and high-dose IL-2 therapy and were assessed for response, toxicity, survival, and immunologic end points.ResultsThirty-four patients received unselected young TILs with a median of 8.0% CD4(+) lymphocytes, and 35 patients received CD8(+)-enriched TILs with a median of 0.3% CD4(+) lymphocytes. One month after TIL infusion, patients who received CD8(+)-enriched TILs had significantly fewer CD4(+) peripheral blood lymphocytes (P = .01). Twelve patients responded to therapy with unselected young TILs (according to Response Evaluation Criteria in Solid Tumors [RECIST]), and seven patients responded to CD8(+)-enriched TILs (35% v 20%; not significant). Retrospective studies showed a significant association between response to treatment and interferon gamma secretion by the infused TILs in response to autologous tumor (P = .04), and in the subgroup of patients who received TILs from subcutaneous tumors, eight of 15 patients receiving unselected young TILs responded but none of eight patients receiving CD8(+)-enriched TILs responded. CONCLUSIONA randomized selection design trial was feasible for improving individualized TIL therapy. Since the evidence indicates that CD8(+)-enriched TILs are not more potent therapeutically and they are more laborious to prepare, future studies should focus on unselected young TILs.
Article: Minimally invasive liver resection to obtain tumor-infiltrating lymphocytes for adoptive cell therapy in patients with metastatic melanoma[Show abstract] [Hide abstract]
ABSTRACT: Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TIL) in patients with metastatic melanoma has been reported to have a 56% overall response rate with 20% complete responders. To increase the availability of this promising therapy in patients with advanced melanoma, a minimally invasive approach to procure tumor for TIL generation is warranted. A feasibility study was performed to determine the safety and efficacy of laparoscopic liver resection to generate TIL for ACT. Retrospective review of a prospectively maintained database identified 22 patients with advanced melanoma and visceral metastasis (AJCC Stage M1c) who underwent laparoscopic liver resection between 1 October 2005 and 31 July 2011. The indication for resection in all patients was to receive postoperative ACT with TIL. Twenty patients (91%) underwent resection utilizing a closed laparoscopic technique, one required hand-assistance and another required conversion to open resection. Median intraoperative blood loss was 100 mL with most cases performed without a Pringle maneuver. Median hospital stay was 3 days. Three (14%) patients experienced a complication from resection with no mortality. TIL were generated from 18 of 22 (82%) patients. Twelve of 15 (80%) TIL tested were found to have in vitro tumor reactivity. Eleven patients (50%) received the intended ACT. Two patients were rendered no evidence of disease after surgical resection, with one undergoing delayed ACT with generated TIL after relapse. Objective tumor response was seen in 5 of 11 patients (45%) who received TIL, with one patient experiencing an ongoing complete response (32+ months). Laparoscopic liver resection can be performed with minimal morbidity and serve as an effective means to procure tumor to generate therapeutic TIL for ACT to patients with metastatic melanoma.
Article: CTLA-4 Blockade with Ipilimumab: Long-term Follow-up of 177 Patients with Metastatic Melanoma[Show abstract] [Hide abstract]
ABSTRACT: Treatment with ipilimumab can cause objective tumor responses in patients with metastatic melanoma. We have treated 177 evaluable patients in three clinical trials and have long-term follow-up to evaluate the durability of responses. Patients with metastatic melanoma were treated in three trials from 2002 to 2005. In protocol 1, 56 patients received ipilimumab with gp100 peptides. In protocol 2, 36 patients received ipilimumab with interleukin-2. In protocol 3, 85 patients received ipilimumab with intrapatient dose-escalation and were randomized to receive gp100 peptides. We have analyzed their long-term follow-up and survival data. With median follow-up for protocols 1, 2, and 3 being 92, 84, and 71 months, median survival was 14, 16, and 13 months with 5-year survival rates being 13%, 25%, and 23%, respectively. Patients in protocol 2 had a 17% complete response (CR) rate, compared with 7% in protocol 1 and 6% in protocol 3. These CR rates are higher than previously reported for the same trials because some patients who eventually became complete responders had continual tumor regression months to years after therapy. All but one of the 15 complete responders are ongoing at 54+ to 99+ months. This report provides the longest follow-up of patients with melanoma treated with ipilimumab and shows that ipilimumab can induce durable, potentially curative tumor regression in a small percentage of patients with metastatic melanoma. The combination of ipilimumab and interleukin-2 seems to have an increased CR rate, but this needs to be tested in a randomized trial.
Article: Durable Complete Responses in Heavily Pretreted Patients with Metastatic Melanoma Using T Cell Transfer Immunotherapy[Show abstract] [Hide abstract]
ABSTRACT: Most treatments for patients with metastatic melanoma have a low rate of complete regression and thus overall survival in these patients is poor. We investigated the ability of adoptive cell transfer utilizing autologous tumor-infiltrating lymphocytes (TIL) to mediate durable complete regressions in heavily pretreated patients with metastatic melanoma. Ninety-three patients with measurable metastatic melanoma were treated with the adoptive transfer of autologous TILs administered in conjunction with interleukin-2 following a lymphodepleting preparative regimen on three sequential clinical trials. Ninety-five percent of these patients had progressive disease following a prior systemic treatment. Median potential follow-up was 62 months. Objective response rates by Response Evaluation Criteria in Solid Tumors (RECIST) in the 3 trials using lymphodepleting preparative regimens (chemotherapy alone or with 2 or 12 Gy irradiation) were 49%, 52%, and 72%, respectively. Twenty of the 93 patients (22%) achieved a complete tumor regression, and 19 have ongoing complete regressions beyond 3 years. The actuarial 3- and 5-year survival rates for the entire group were 36% and 29%, respectively, but for the 20 complete responders were 100% and 93%. The likelihood of achieving a complete response was similar regardless of prior therapy. Factors associated with objective response included longer telomeres of the infused cells, the number of CD8(+)CD27(+) cells infused, and the persistence of the infused cells in the circulation at 1 month (all P(2) < 0.001). Cell transfer therapy with autologous TILs can mediate durable complete responses in patients with metastatic melanoma and has similar efficacy irrespective of prior treatment. Clin Cancer Res; 17(13); 4550-7. ©2011 AACR.
Article: Assessment of Ovarian Function After Preparative Chemotherapy and Total Body Radiation for Adoptive Cell Therapy[Show abstract] [Hide abstract]
ABSTRACT: The aim of the study is to analyze treatment-induced gonadal damage and premature ovarian failure after adoptive cell therapy (ACT) after a cytotoxic lymphodepleting preparative regimen. Records of 66 consecutive females who received ACT at the Surgery Branch, National Cancer Institute, NIH (Bethesda, MD) were reviewed. Patients received a conditioning regimen of high-dose cyclophosphamide (60 mg/kg x 2 doses) and fludarabine (25 mg/m² x 5 doses). Some patients also received total body radiation at 200 or 600 cGy. Assessment of ovarian function was determined by analysis of monthly follicle stimulating hormone (FSH) levels, menstrual history, and symptoms. Among patients with serum available and normal pretreatment ovarian function, 21 had a preparative regimen with chemotherapy alone and 5 patients had received chemotherapy with total body radiation. Nine (43%) patients in the chemotherapy cohort and all 5 patients in the chemotherapy plus total body radiation cohort had persistently elevated FSH levels and were given the diagnosis of premature ovarian failure. Twelve (57%) patients had normal FSH levels at 6 months posttreatment. Median age of all patients at treatment was 34 years. Median age of women retaining normal ovarian function was 30 (range, 19-45) vs. 41 years (range, 30-49) for those who did not regain function. The conditioning regimen of 2 doses of cyclophosphamide (60 mg/kg) and 5 doses of fludarabine (25 mg/m²) may induce gonadal damage and premature ovarian failure. Younger age at treatment was associated with a higher frequency of normal ovarian function posttreatment, whereas adding total body radiation was associated with a high risk of ovarian failure.
Article: CD8+ Enriched "Young" Tumor Infiltrating Lymphocytes Can Mediate Regression of Metastatic Melanoma[Show abstract] [Hide abstract]
ABSTRACT: Tumor-infiltrating lymphocytes (TIL) and interleukin (IL)-2 administered following lymphodepletion can cause the durable complete regression of bulky metastatic melanoma in patients refractory to approved treatments. However, the generation of a unique tumor-reactive TIL culture for each patient may be prohibitively difficult. We therefore investigated the clinical and immunologic impact of unscreened, CD8+ enriched "young" TIL. Methods were developed for generating TIL that minimized the time in culture and eliminated the individualized tumor-reactivity screening step. Thirty-three patients were treated with these CD8+ enriched young TIL and IL-2 following nonmyeloablative lymphodepletion (NMA). Twenty-three additional patients were treated with CD8+ enriched young TIL and IL-2 after lymphodepletion with NMA and 6 Gy of total body irradiation. Young TIL cultures for therapy were successfully established from 83% of 122 consecutive melanoma patients. Nineteen of 33 patients (58%) treated with CD8+ enriched young TIL and NMA had an objective response (Response Evaluation Criteria in Solid Tumors) including 3 complete responders. Eleven of 23 patients (48%) treated with TIL and 6 Gy total body irradiation had an objective response including 2 complete responders. At 1 month after TIL infusion the absolute CD8+ cell numbers in the periphery were highly correlated with response. This study shows that a rapid and simplified method can be used to reliably generate CD8+ enriched young TIL for administration as an individualized therapy for advanced melanoma, and may allow this potentially effective treatment to be applied at other institutions and to reach additional patients.
Article: Thoracic metastasectomy for adoptive immunotherapy of melanoma: A single-institution experience[Show abstract] [Hide abstract]
ABSTRACT: Although refractory to chemotherapy, metastatic melanoma may respond to adoptive immunotherapy. As novel treatments evolve, surgeons may be asked to perform metastasectomy not only for palliation or potential cure but also for isolation of tumor-infiltrating lymphocytes. This study was undertaken to examine outcomes of patients with melanoma undergoing thoracic metastasectomy in preparation for investigational immunotherapy. A retrospective review identified 107 consecutive patients who underwent 116 thoracic metastasectomy procedures from April 1998 to July 2009. Indications for surgical intervention included procurement of tumor-infiltrating lymphocytes, rendering of patients to no evaluable disease status, palliation, and diagnosis. Response Evaluation Criteria in Solid Tumors criteria were used to assess tumor response. Thoracotomy, lobectomy, and video-assisted thoracoscopic surgery with nonanatomic resection were the most common procedures. Major complications included 1 death and 1 coagulopathy-induced hemothorax. Seventeen patients were rendered to no evaluable disease status. Virtually all patients with residual disease had tumor specimens cultured for tumor-infiltrating lymphocytes; approximately 70% of tumor-infiltrating lymphocyte cultures exhibited antitumor reactivity. Of the 91 patients with residual or recurrent disease, 24 (26%) underwent adoptive cell transfer of tumor-infiltrating lymphocytes, of whom 7 exhibited objective responses (29% response rate and 8% based on intent to treat). Rapid disease progression precluded tumor-infiltrating lymphocyte therapy in most cases. Actuarial 1- and 5-year survival rates for patients rendered to no evaluable disease status or receiving or not receiving tumor-infiltrating lymphocytes were 93% and 76%, 64% and 33%, and 43% and 0%, respectively. Relatively few patients currently having thoracic metastasectomy undergo adoptive cell transfer. Continued refinement of tumor-infiltrating lymphocyte expansion protocols and improved patient selection might increase the number of patients with melanoma benefiting from these interventions.
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ABSTRACT: To determine the objective response rate and response duration of melanoma brain metastases to adoptive cell therapy (ACT) with autologous antitumor lymphocytes plus interleukin-2 following a lymphodepleting preparative regimen. Methods: Between 2000 and 2009, 264 patients with metastatic melanoma received ACT, consisting of cyclophosphamide and fludarabine with or without total body irradiation, followed by the infusion of autologous tumor-infiltrating lymphocytes (TIL) or autologous peripheral blood lymphocytes retrovirally transduced to express a T-cell receptor (TCR) that recognized the melanocyte differentiation antigens gp-100 or MART-1. From this group, 26 patients were retrospectively identified to have had untreated brain metastases and extracranial disease before receiving ACT. The response rate and duration of melanoma brain metastases, as well as the overall response rate, response duration, and survival for these patients, are presented. Seventeen of these 26 patients received ACT with TIL. Seven of these patients (41%) achieved a complete response in the brain, and six patients achieved an overall partial response. In the nine patients that received TCR-transduced lymphocytes, two patients achieved a complete response in the brain (22%) and one of these two achieved an overall partial response. One patient developed a tumor-associated subarachnoid hemorrhage during the thrombocytopenic phase of therapy and had an uneventful metastatectomy. ACT with a nonmyeloablative preparative regimen using either TIL- or TCR gene-transduced cells and interleukin-2 can mediate complete and durable regression of melanoma brain metastases. This strategy can be used safely in selected patients with metastatic melanoma to the brain.
Article: Liver Resection for Metastatic Melanoma with Post-Operative Tumor-Infiltrating Lymphocyte Therapy[Show abstract] [Hide abstract]
ABSTRACT: Background Patients with metastatic melanoma to the liver (MML) have a median survival of 4 to 6 months. This study evaluated patients who underwent liver resection with intent to receive postoperative tumor-infiltrating lymphocyte (TIL) therapy. Methods Retrospective analysis of a prospective database identified patients with MML who underwent liver resection from 1980 to 2008. Results A total of 539 patients had MML, and 39% (204 of 539) had tumor collected for TIL. A total of 17% (35 of 204) underwent liver resection for TIL. The 3-year overall survival was 53%. Lack of extrahepatic disease (P = .026), negative margin (P = .056), and single hepatic metastasis (P = .04) predicted survival after univariate analysis. Only lack of extrahepatic disease remained a significant predictor of survival after multivariate analysis (P = .043). A total of 31% (11 of 35) underwent complete resection without TIL, and 69% (24 of 35) underwent resection with synchronous intrahepatic and extrahepatic disease with intent to receive TIL. For 9 of 11 patients (2 of 11 excluded for gene therapy), 3-year survival was 80%. A total of 4 (44%) of 9 experienced recurrence, with a median disease-free survival of 1.2 years. For 24 patients (69%) with residual disease, 3-year survival was 51% (2 of 24 excluded for gene therapy). A total of 63% (15 of 24) received postoperative TIL (3-year survival 65%), and 29% (7 of 24) did not. A total of 40% (6 of 15) had disease that partially responded to TIL; the disease of 67% (4 of 6) had not progressed at median follow-up of 55 months (range, 42–197+ months). The seven patients who did not receive TIL had a median survival of 4.6 months. Conclusions Resection of MML with TIL should be considered because it can result in prolonged survival in a highly selected group of patients.
Article: Tumor Antigen-specific CD8 T Cells Infiltrating the Tumor Express High Levels of PD-1 and are Functionally Impaired[Show abstract] [Hide abstract]
ABSTRACT: Tumor antigen-specific T cells are found within melanomas, yet tumors continue to grow. Although the tumor microenvironment is thought to influence the suppression of tumor-reactive T cells, the underlying mechanisms for this T-cell dysfunction are not clear. Here, we report that the majority of tumor infiltrating T lymphocytes (TIL), including MART-1/Melan-A melanoma antigen-specific CD8 T cells, predominantly expressed PD-1, in contrast to T cells in normal tissues and peripheral blood T lymphocytes (PBL). PD-1(+) TIL expressed CTLA-4 and Ki-67, markers that were not expressed by PD-1(-) TIL and T cells in the normal tissues and PBL. Moreover, PD-1(+) TIL were primarily HLA-DR(+) and CD127(-), in contrast to PD-1(-) TIL. Effector cytokine production by PD-1(+) TIL was impaired compared with PD-1(-) TIL and PBL. Collectively, the phenotypic and functional characterizations of TIL revealed a significantly higher frequency and level of PD-1 expression on TIL compared with normal tissue T-cell infiltrates and PBL, and PD-1 expression correlated with an exhausted phenotype and impaired effector function. These findings suggest that the tumor microenvironment can lead to up-regulation of PD-1 on tumor-reactive T cells and contribute to impaired antitumor immune responses.
Article: Adoptive Cell Therapy for Patients With Metastatic Melanoma: Evaluation of Intensive Myeloablative Chemoradiation Preparative Regimens[Show abstract] [Hide abstract]
ABSTRACT: The two approved treatments for patients with metastatic melanoma, interleukin (IL)-2 and dacarbazine, mediate objective response rates of 12% to 15%. We previously reported that adoptive cell therapy (ACT) with autologous antitumor lymphocytes in lymphodepleted hosts mediated objective responses in 51% of 35 patients. Here, we update that study and evaluate the safety and efficacy of two increased-intensity myeloablative lymphodepleting regimens. We performed two additional sequential trials of ACT with autologous tumor-infiltrating lymphocytes (TIL) in patients with metastatic melanoma. Increasing intensity of host preparative lymphodepletion consisting of cyclophosphamide and fludarabine with either 2 (25 patients) or 12 Gy (25 patients) of total-body irradiation (TBI) was administered before cell transfer. Objective response rates by Response Evaluation Criteria in Solid Tumors (RECIST) and survival were evaluated. Immunologic correlates of effective treatment were studied. Although nonmyeloablative chemotherapy alone showed an objective response rate of 49%, when 2 or 12 Gy of TBI was added, the response rates were 52% and 72% respectively. Responses were seen in all visceral sites including brain. There was one treatment-related death in the 93 patients. Host lymphodepletion was associated with increased serum levels of the lymphocyte homeostatic cytokines IL-7 and IL-15. Objective responses were correlated with the telomere length of the transferred cells. Host lymphodepletion followed by autologous TIL transfer and IL-2 results in objective response rates of 50% to 70% in patients with metastatic melanoma refractory to standard therapies.
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ABSTRACT: To identify prognostic factors associated with survival beyond 4 years and overall response in patients with metastatic melanoma treated with high-dose bolus i.v. interleukin-2 (IL-2) given either alone or in combination with a variety of melanoma vaccines. 684 consecutive patients with metastatic melanoma received high-dose bolus i.v. IL-2 either alone or in conjunction with a variety of melanoma vaccines. Treatments occurred between August 1, 1985 and January 1, 2006. The overall objective response rate was 13% for patients receiving IL-2 alone and 16% for patients who received IL-2 with vaccine. In patients treated with IL-2 alone (n=305) and IL-2 with vaccine (n=379), having an objective response was associated with survival beyond 4 years (P<0.0001). No pretreatment factors could be identified that were strongly associated with increased rate of objective response or long-term survival in patients receiving IL-2 alone. In patients receiving IL-2 with vaccines, there were increased response rates in patients with s.c. or cutaneous disease only and lower response rates with visceral disease only. Patients who received the gp100:209-217(210M) peptide plus IL-2 showed a strong trend to increased objective responses compared with IL-2 alone (22% versus 12.8%; P=0.01) and also compared with patients who received a variety of vaccines that did not include this immunogenic peptide (13.8%; P=0.009). IL-2 can produce a modest response rate in patients with metastatic melanoma including patients with durable complete responses. S.c. or cutaneous disease only and vaccination with gp100:209-217(210M) peptide was associated with significant increase in response rates.
Article: Downey SG, Klapper JA, Smith FO, Yang JC, Sherry RM, Royal RE, Kammula US, Hughes MS, Allen TE, Levy CL, Yellin M, Nichol G, White DE, Steinberg SM, Rosenberg SAPrognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade. Clin Cancer Res 13: 6681-6688[Show abstract] [Hide abstract]
ABSTRACT: CTL-associated antigen 4 (CTLA-4) can inhibit T-cell activation and helps maintain peripheral self-tolerance. Previously, we showed immune-related adverse events (IRAE) and objective, durable clinical responses in patients with metastatic melanoma treated with CTLA-4 blockade. We have now treated 139 patients in two trials and have sufficient follow-up to examine factors associated with clinical response. A total of 139 patients with metastatic melanoma were treated: 54 patients received ipilimumab in conjunction with peptide vaccinations and 85 patients were treated with intra-patient dose escalation of ipilimumab and randomized to receive peptides in accordance with HLA-A*0201 status. Three patients achieved complete responses (CR; ongoing at 29+, 52+, and 53+ months); an additional 20 patients achieved partial responses (PR) for an overall objective response rate of 17%. The majority of patients (62%, 86 of 139) developed some form of IRAE, which was associated with a greater probability of objective antitumor response (P = 0.0004); all patients with CR had more severe IRAEs. Prior therapy with IFNalpha-2b was a negative prognostic factor, whereas prior high-dose interleukin-2 did not significantly affect the probability of response. There were no significant differences in the rate of clinical response or development of IRAEs between the two trials. The duration of tumor response was not affected by the use of high-dose steroids for abrogation of treatment-related toxicities (P = 0.23). There were no treatment-related deaths. In patients with metastatic melanoma, ipilimumab can induce durable objective clinical responses, which are related to the induction of IRAEs.
Article: Administration of a CD25-Directed Immunotoxin, LMB-2, to Patients with Metastatic Melanoma Induces a Selective Partial Reduction in Regulatory T Cells In Vivo[Show abstract] [Hide abstract]
ABSTRACT: CD25+ CD4+ T regulatory (Treg) cells regulate peripheral self tolerance and possess the ability to suppress antitumor responses, which may in part explain the poor clinical response of cancer patients undergoing active immunization protocols. We have previously shown that in vitro incubation of human PBMC with LMB-2, a CD25-directed immunotoxin, significantly reduced CD25+ FOXP3+ CD4+ Treg cells without impairing the function of the remaining lymphocytes. In the current study, eight patients with metastatic melanoma were treated with LMB-2 followed by MART-1 and gp100-specific peptide vaccination. LMB-2 administration resulted in a preferential, transient reduction in mean circulating CD25+ CD4+ T cell number, from 83 +/- 16 cells/microl to a nadir of 17 +/- 5 cells/microl, a 79.1% reduction. FOXP3 analysis revealed a less robust depletion with mean FOXP3+ CD4+ Treg cell number decreasing from 74 +/- 15 cells/microl to 36 +/- 8 cells/microl, a 51.4% reduction. FOXP3+ CD4+ Treg cells that survived LMB-2-mediated cytotoxicity expressed little or no CD25. Similar to the peripheral blood, immunohistochemical analysis showed a 68.9% mean reduction in FOXP3+ CD4+ Treg cell frequency in evaluable lesions. Despite inducing a reduction in Treg cell numbers in vivo, LMB-2 therapy did not augment the immune response to cancer vaccination and no patient experienced an objective response or autoimmunity. These data demonstrate the capacity of a CD25-directed immunotoxin to selectively mediate a transient partial reduction in circulating and tumor-infiltrating Treg cells in vivo, and suggest that more comprehensive Treg cell elimination may be required to bolster antitumor responses in patients with metastatic melanoma.
Article: Ipilimumab (Anti-CTLA4 Antibody) Causes Regression of Metastatic Renal Cell Cancer Associated With Enteritis and Hypophysitis[Show abstract] [Hide abstract]
ABSTRACT: The inhibitory receptor CTLA4 has a key role in peripheral tolerance of T cells for both normal and tumor-associated antigens. Murine experiments suggested that blockade of CTLA4 might have antitumor activity and a clinical experience with the blocking antibody ipilimumab in patients with metastatic melanoma did show durable tumor regressions in some patients. Therefore, a phase II study of ipilimumab was conducted in patients with metastatic renal cell cancer with a primary end point of response by Response Evaluation Criteria in Solid Tumors (RECIST) criteria. Two sequential cohorts received either 3 mg/kg followed by 1 mg/kg or all doses at 3 mg/kg every 3 weeks (with no intention of comparing cohort response rates). Major toxicities were enteritis and endocrine deficiencies of presumed autoimmune origin. One of 21 patients receiving the lower dose had a partial response. Five of 40 patients at the higher dose had partial responses (95% confidence interval for cohort response rate 4% to 27%) and responses were seen in patients who had previously not responded to IL-2. Thirty-three percent of patients experienced a grade III or IV immune-mediated toxicity. There was a highly significant association between autoimmune events (AEs) and tumor regression (response rate=30% with AE, 0% without AE). CTLA4 blockade with ipilimumab induces cancer regression in some patients with metastatic clear cell renal cancer, even if they have not responded to other immunotherapies. These regressions are highly associated with other immune-mediated events of presumed autoimmune origin by mechanisms as yet undefined.
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ABSTRACT: A phase I study was conducted to assess the safety of adoptive immunotherapy using gene-modified autologous T cells for the treatment of metastatic ovarian cancer. T cells with reactivity against the ovarian cancer-associated antigen alpha-folate receptor (FR) were generated by genetic modification of autologous T cells with a chimeric gene incorporating an anti-FR single-chain antibody linked to the signaling domain of the Fc receptor gamma chain. Patients were assigned to one of two cohorts in the study. Eight patients in cohort 1 received a dose escalation of T cells in combination with high-dose interleukin-2, and six patients in cohort 2 received dual-specific T cells (reactive with both FR and allogeneic cells) followed by immunization with allogeneic peripheral blood mononuclear cells. Five patients in cohort 1 experienced some grade 3 to 4 treatment-related toxicity that was probably due to interleukin-2 administration, which could be managed using standard measures. Patients in cohort 2 experienced relatively mild side effects with grade 1 to 2 symptoms. No reduction in tumor burden was seen in any patient. Tracking 111In-labeled adoptively transferred T cells in cohort 1 revealed a lack of specific localization of T cells to tumor except in one patient where some signal was detected in a peritoneal deposit. PCR analysis showed that gene-modified T cells were present in the circulation in large numbers for the first 2 days after transfer, but these quickly declined to be barely detectable 1 month later in most patients. An inhibitory factor developed in the serum of three of six patients tested over the period of treatment, which significantly reduced the ability of gene-modified T cells to respond against FR+ tumor cells. Large numbers of gene-modified tumor-reactive T cells can be safely given to patients, but these cells do not persist in large numbers long term. Future studies need to employ strategies to extend T cell persistence. This report is the first to document the use of genetically redirected T cells for the treatment of ovarian cancer.
Article: Evaluation of Prime/Boost Regimens Using Recombinant Poxvirus/Tyrosinase Vaccines for the Treatment of Patients with Metastatic Melanoma[Show abstract] [Hide abstract]
ABSTRACT: Two clinical trials were conducted to evaluate the clinical efficacy and immunologic impact of vaccination against the tyrosinase protein plus systemic interleukin 2 (IL-2) administration in patients with advanced metastatic melanoma. Full-length tyrosinase was employed as an immunogen to induce diverse immunologic responses against a commonly expressed melanoma antigen. Heterologous prime/boost vaccination with recombinant vaccinia and fowlpox vectors encoding tyrosinase was first explored in a randomized three-arm phase II trial, in which vaccines were administered alone or concurrently with low-dose or high-dose IL-2. In a subsequent single cohort phase II trial, all patients received the same vaccines and high-dose IL-2 sequentially rather than concurrently. Among a total of 64 patients treated on these trials, 8 objective partial responses (12.5%) were observed, all in patients receiving high-dose IL-2. Additional patients showed evidence of lesional regression (mixed tumor response) or overall regression that did not achieve partial response status (minor response). In vitro evidence of enhanced immunity against tyrosinase following protocol treatments was documented in 3 of 49 (6%) patients tested serologically, 3 of 23 (13%) patients tested for T-cell recognition of individual tyrosinase peptides, and 4 of 16 (25%) patients tested for T-cell recognition of full-length tyrosinase protein with real-time reverse transcription-PCR techniques. Whereas prime/boost immunization with recombinant vaccinia and fowlpox viruses enhanced antityrosinase immunity in some patients with metastatic melanoma, it was ineffective alone in mediating clinical benefit, and in combination with IL-2 did not mediate clinical benefit significantly different from that expected from treatment with IL-2 alone.
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ABSTRACT: Efforts to develop effective cancer vaccines often use combinations of immunogenic peptides to increase the applicability and effectiveness of the immunizations. The immunologic consequences of combining more than 1 self/tumor antigen in a single vaccine emulsion remain unclear, however. We performed 2 sequential clinical trials in patients at high risk for melanoma recurrence. Patients were given the highly immunogenic gp100:209-217(210M) peptide and the less immunogenic tyrosinase:368-376(370D) peptide once every 3 weeks for 4 weeks. This vaccination course was 12 weeks long, and patients were vaccinated for up to 4 courses (16 total vaccinations). In the first trial in 31 patients, the peptides were emulsified separately in incomplete Freund adjuvant and injected at 2 different sites. In the second trial in 33 patients, the peptides were emulsified together and injected at the same site. Cryopreserved lymphocytes were obtained by apheresis after each course and were evaluated for antipeptide activity using tetramer, enzyme-linked immunospot, and in vitro sensitization boost assays. When the peptides were injected at separate sites, robust specific reactivity to the native gp100:209-217 peptide was measured by each of the assays, whereas immunization with the tyrosinase:368-376(370D) peptide was far less effective. When the peptides were emulsified and injected together at the same site, immunization to the gp100:209-217(210M) epitope dropped precipitously, whereas reactivity to the tyrosinase:368-376(370D) peptide was enhanced. These cautionary data indicate that mixing peptides in the same emulsion can alter reactivity compared with peptides injected separately by mechanisms that may include the induction of localized nonspecific inflammation or competitive binding of peptides to major histocompatibility complex molecules.
Top Journals
- Journla of Immunotherapy (12)
- Clinical Cancer Research (10)
- Cancer (4)
- Annals of Surgery (3)
- Cancer (3)
Sidra Medical and Research CenterAd Dawḩah, Baladīyat ad Dawḩah, Qatar
National Cancer Institute (USA)
Maryland, United States
- Surgery Branch
NCI-FrederickФредерик, Maryland, United States
National Cancer InstituteΜπογκοτά, Bogota D.C., Colombia
National Institutes of Health
Maryland, United States
- • Branch of Surgery
- • Branch of Radiation Oncology


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- Nils R.Germany
Nordrhein WestfalenFeel my presence
It's been seven years since I discovered my love for boardgaming and started to make my annual pilgrimage to Essen, but this is the first time I actually put my thoughts of the fair down in written form (mainly because some good friends asked me to).Recommend
What you will find here are some personal thoughts about new games presented at Essen 09, and a listing of the purchases I made. All in all I think 2009 was a good, but not spectacular year. I've seen some very solid designs and interesting themes, but no game in particular that was so outstanding I bought it without a second thought. I mainly focus on small publishers, and you won't find any news on the following games here:
-Dungeon Lords
-Vasco da Gama
The reason for this is quite simple: All of them will be available at my local gamestore next week, where I can test them in depth and buy a copy of the ones I like, so I had no reason to check them out at Essen (and in case of some games fight for a table place). I also read the rules of all said titles beforehand and none of them impressed me as much as I hoped, but time will tell.
- Posted Mon Oct 26, 2009 9:06 pm
- [+] Dice rolls

subset: commoncrawl


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Massive Graphic is a leader in online and print marketing on the Sunshine Coast, BC
We have full web design services including Search Engine Optimization, as well as all-round Graphic design solutions.
We achieve this by having a team of highly talented web designers and graphic designers that are able to create a website or print design that is both professional and affordable. Visit our contact page or email us to let Massive Graphic assist with your project!
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Working with suppliers, printers, illustrators, editors and photographers, Massive Graphic can effectively implement any size of project – on time, and within budget. Massive Graphic manages the design process from concept to printer, ensuring outstanding quality. We can assist in developing or refreshing your corporate identity and branding. Read More >>


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Gisele Caroline Bündchen (born 20 July 1980) is a Brazilian fashion model, actress, and producer. She is the Goodwill Ambassador for the United Nations Environment Programme.
List of links to Gisele Bündchen fansites:


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A lot of bottles get cut up around here, somewhere around 60 a week, and I've never been able to figure out what to do with the shoulder section of the bottles. I usually just pitch it into the city glass recycling system, which is fine I suppose. But it would be nice if I could just use them up.
Tag Archive for Bottle Glass Fusing for beginners
Leaf and Droplet Glass Donuts
Glassline Paint on Fused Bottles
I've been entertaining myself in the studio with one of my new toys. After making color test strips, I decided to do some playing around with the Glassline paints I got for Christmas. Read more
Fusing Large and Small Bottles
Answering the age old question that is keeping us all awake at night:
Do large and small bottles fuse the same?
Let's try it and see: Read more


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Michael ChambersTwitter Stats
@MitchKambers - Tracking since September 25, 2008
Often described as Odd.
middle of nowhere
Michael Chambers Tweets
@MitchKambers has posted 97 tweets in the last 30 days, which translates to an average of 3.2 tweets per day.
Michael Chambers Followers
@MitchKambers has 94 followers.
This account is #54,059,598 in the worldwide rank of the most popular Twitter users.
Michael Chambers Following
@MitchKambers is following 611 Twitter accounts.
Last month this account followed 16 users.
Michael Chambers Predictions & Milestones
@MitchKambers will hit 87 followers in the next 3 months, and 66 in one year.
You are on Michael Chambers's Twitter stats page
We track these Twitter stats since September 25, 2008 . You can see how many followers Michael Chambers lost or gained and what the prediction is for tomorrow or the next 15 days, together with all kinds of other stats like rank compared to all Twitter users, tweets etc.
Why don't you give it a try and compare Michael Chambers to yourself ? Or if you are Michael Chambers get even more feature rich & up-to-date stats with Premium & Pro Twitter Stats.
Twitter Counter is the #1 Twitter stats site powered by Twitter. It all started in June 12, 2008 and we grew rather rapidly because of our Twitter Counter badge. The button is a nice small image that shows your visitors how many followers you have on Twitter. Within a year the button was on many many blogs around the world and we displayed more than 100 million buttons in one month. We track follower stats for over 180 million users now.


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Translation of cross-ownership in Spanish:
- uncountablepropiedad (feminine) cruzadaExample sentences
- From a legal standpoint, he questions whether the corporate form, as a legal entity, is challenged by complex network patterns of cross-ownership.
- This is especially important as the industry faces key public policy issues regarding cross-ownership and ownership caps.
- They were the only two broadcast outlets that seriously covered the issue of ownership caps and cross-ownership.
Definition of cross-ownership in:
- British & World English dictionary
- US English dictionary
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Comments that don't adhere to our Community Guidelines may be moderated or removed.
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May 24, 2014
Oregon QB transfer Jake Rodrigues signs with SDSU
Jake Rodrigues intends to transfer to San Diego State this summer, AztecSportsReport.com has learned. The former four-star QB out of Rocklin (Calif.) Whitney high school began his official visit to SDSU on Thursday and made his final decision during dinner with the coaching staff on Friday evening. He filled out all of the necessary paperwork and, according to sources, was approved by San Diego State's compliance department midday Saturday.Oregon transfer quarterback
After Rordrigues asked for his release from Oregon earlier this month, programs such as Miami, Michigan, Texas and Utah State were also in consideration at one point or another, but Rodrigues told ASR on Wednesday that he was down to UT and San Diego State.
"I'm just looking for a place with a senior quarterback graduating next year and a place where the coaches believe in me," Rodrigues said at the time. "The player-coach relationship is the most important thing. They're like your family away from home and that's very important.
"I'm also coming from, by far, the best facilities in the world football-wise (Oregon), but I don't really care about that stuff. I know that wherever I go, it probably isn't going to get better than this, but it's something that isn't important to me. I don't really care about it. As long as there is a weight room that I can work out in and a set of pads for me to play football, it doesn't really matter."
An official visit to Austin, Texas was potentially set to happen as soon as next week, but the 6-foot-3, 215-pound signal caller is done with the recruiting process and locked into SDSU.
Former San Diego State offensive coordinator Andy Ludwig recruited Rodrigues out of high school - along with schools such as Nebraska and more than half of the Pac-12 - but now that Ludwig is currently at Wisconsin, Aztecs quarterback coach Brian Sipe and director of player personnel Kevin McGarry led his recruitment this time around.
"Coach (Sipe) talked about me just making plays and leading the team, putting our players in the right situation, being a leader, throwing the ball in the right place and being accurate," Rodrigues said. "I've also been blessed with athleticism in my feet so I can run if I have to.
"They're really excited, I'm really excited and I can't wait to see what comes of this."
Due to NCAA transfer rules, Rodrigues will not be eligible to play until the 2015 season. He can officially enroll at SDSU once he completes his current courses by the end of this quarter at Oregon (which will finish up in June), but he will be limited to working out and practicing with the Aztecs when he reports to campus in July.
"I'll be sitting out my first year there but I'm going to practice and prepare as if I'm playing," he said. "If I didn't do that, I'd be selling myself short. I hope the (current) guys on the team will see how hard I work and what this team means to me. It's very important to me."
Take advantage of the Rivals99 deal while it last: Get free SDSU gear and premium access to AztecSportsReport.com!
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Resurging of Darkness by LucasValencioWatch
©2012-2016 LucasValencio
acho de mais essa sua arte - show
Awesome work
Amazing, Im learning how to paint in Photoshop and I wanted to ask how do you paint the lighting and the light rays and all of that stuff?
Wow what an Idea
brilliant idea!
Woah... that is absolutely stunning! Wonderful job!
I can't believe how you transformed that statue into this. AMAZING.
This is awesome Ö
Wow amazing my friend
really nice , you make wonderfull works on the horse it's very beautifull
WOW! Love the concept & your work!
a wonderful work dear
Wonderful work!
Woah what a great job you did on this one! <3
aah maravilhoso!!
Very cool!
Nice !
wow! Excellent art
Muito lindo!Cores lindas,atmosfera incrível vc conseguiu aqui!
Um trabalho de encher os olhos!Parabéns Lucas!
Um trabalho de encher os olhos!Parabéns Lucas!
Wow! Very beautiful!


text: Paid a visit to U Gussu yesterday after receiving a recommendation from an Italian friend. We strolled in at lunchtime and received a warm welcome. We were quite late into the lunchtime service and it was very quiet indeed. Outside seating was decent enough located in a quiet, shady square away... read more


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22 Recent Deviations
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deviation in storage by Irooyo
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deviation in storage by KULAMA
deviation in storage by KULAMA
KHR FanFic: PrologueSmack. And within seconds, the boy was held into a tight head-lock begging for mercy. "Still a zero, Dame-Tsuna." Reborn sighed and stepped away from the now cowering Tsuna. "Even after everything I taught you." Shaking his head in disapproval, he took a hold of Leon who slowly transformed in a gun, locked, loaded and ready to shoot. "You need to study harder. With your dying will." Knock, knock, knock. Silence. "Saved by the bell, Dame-Tsuna" Leon switched to a chameleon and was settled back onto the rim of Reborn's fedora.KHR FanFic: Prologue by Mayardin More Like This
deviation in storage by Puchiko-Chan
Happy Birthday Shoichi IrieStorm clouds rolling in the sky were probably not one of the redheads concerns at the moment. No. His biggest concern right now was that he was home alone. Okay, so it wasn't really that big off a deal, except for it was his birthday. And he was home alone. Had his sister and mom forgotten? Really?Happy Birthday Shoichi Irie by Rainbowberryrain More Like This


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If you're afraid of butter, use cream. Julia Child
If you're afraid of butter, use cream. Julia Child
Stereo egging w/ xl and med eggs! BBQ guru
It may be several by now. It has been a few years. You leave those things alone in the dark and they tend to multiply. I know.double said:I'm hoping he got his egg, the post started December 2010, I hope it was the Large.
I start the packer draped over a large bowl in the middle of the grill. Halfway through the cook the meat has shrunk enough that I can remove the bowl and set the brisket flat.Lit said:Also with briskets your pretty much stuck cooking flats since full packers barely fit in the large.


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A Little About Me:
A survivor of childhood abuse and neglect.
I've had Complex Post-traumatic Stress Disorder for around 20 years.
As a result, I have spent much of my life completely mute.
I also have retained my Eidetic Memory from early childhood.
My Story
Facebook: www.facebook.com/Katanimate
Blog: katanimate.blogspot.com/
Email: katanimate(at)gmail(dot)com
Doodle Commissions OPENREAD ENTIRE JOURNAL BEFORE COMMENTING READ ENTIRE JOURNAL BEFORE COMMENTING READ ENTIRE JOURNAL BEFORE COMMENTING
I've been spending 3-4 times the number of hours on my doodles as of late, so I've bumped up the price! This will also make it much more likely that I will choose to take your commission, as there will be fewer people applying for them X3
What is a "doodle"?
A doodle is a free-reign, quick commission. They range from a head-shot to full body, monotone to full color. Depends on what I want to paint, they are guaranteed to be fully shaded/painterly quality. I can draw any species, humans and fantasy critters.
I have the right to decline your commission for whatever reason.
I DON'T DO NSFW (adult rated), sorry.
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Top Definition
a motorcycle windshield
rule #1...in town, bug killers are for pussys and old folks riding touring bikes. exception to the rule...lads on a real trip, sporting out of state/province plates.
by Ez Rider July 22, 2006
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Chipmaker's first-quarter revenue hits $1.18 billion, down 21 percent from last year but better than reported estimates from analysts.
Fiber-optic network company Williams Communications reported a hefty loss Monday. For the fourth quarter, the Tulsa, Okla.-based company reported a net loss of $546.6 million, or $1.18 a share, compared with a loss of $74.0 million, or 16 cents a share, in the year-ago period. First Call consensus analysts' estimate was for a loss of 48 cents a share. Williams said its earnings from continuing operations before interest, taxes, depreciation and amortization and other adjustments (EBITDA) topped estimates. The company, 85-percent owned by energy company Williams Cos., said it was confident it would meet or exceed 2001 analysts' estimates for total network revenues that range between $1.3 billion and $1.4 billion.
The maker of application development and deployment tools makes $22.8 million, or $1.18 per share, for the fiscal year, 135 percent more than the firm made in 1997.
In an effort to boost its e-commerce offerings, Hewlett-Packard says it will acquire VeriFone in a stock swap worth $1.18 billion.


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Wood, Paul and Rusinek, Alexis and Pesci, R and Rosochowski, Andrzej and Olejnik, Lech (2012) Effect of grain size and stress state on the behaviour of Magnesium AZ31b alloy. In: Dynamic Behavior of Materials and Safety of Structures, 2012-05-02 - 2012-05-04, Poznan.Full text not available in this repository. (Request a copy from the Strathclyde author)
This speech explores the Effect of grain size and stress state on the behaviour of Magnesium AZ31b
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New Zealand AdoptionsEdit This Page
From FamilySearch Wiki
New Zealand Adoptions
Receiving Your Original Birth Certificate
If you were adopted in New Zealand, and live in New Zealand, and are 20 years of age, and want to get your original Birth Certificate, please contact your local Child Youth and Family office, and ask for the Adoption Support Dept. They will give you the relevant form, cost, Counsellor List, and information required by the Birth Death and Marriage Dept. for you to receive your original birth certificate.
Further information on this process is available from the Registrar-General's website
If you were adopted in New Zealand, and live overseas and want your original birth certificate. please send $15 (price as at Nov. 2008) along with the relevant information requested below. As prices may change, you can check the price on this website.
Send your request to:
Registrar General
Birth Death and Marriages
P. O. Box 10526,
Marked: Attention Adult Adoption Information Officer.
Put todays date, your name, current address and phone number and email address. Then underneath that put your
Full Adopted Name
Date of Birth
Place of Birth
Full Name of Adoptive Father
Full Name of Adoptive Mother
Your signature
Send this away with the relevant sum of money, to the above address. As one is living overseas, your Certificate will be sent directly to you.
More information about anything to do with Adoption is available on www.cyf.govt.nz/1570.btm
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Best Hip-Hop Producer (2008)
Mike Dean
When it comes to music, there's seldom the chance to correctly use the word pioneer in describing an artist. However, when it comes to Mike Dean, nobody would argue the validity of those two words being used in one sentence. He's singlehandedly shaped Houston's hip-hop sound for some time, and the roster of rappers he's worked with is longer than you can imagine. He's worked with everyone from Tupac to Kanye — yes, that Tupac, and really, that Kanye. UGK, The Geto Boys, Devin the Dude and Z-Ro...no other man has had such an influence over the sounds of the Bayou City and brought so many to an international audience.
More Arts & Entertainment Awards
Best Band NameThe Dimes(Now Called) Young Mammals
Best Unofficial Private ClubThe Next Door Bar
Best Tattoo ArtistAntoine at Texas Tattoo
Best StripperAngelic at The Colorado Bar & Grill


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U.S. Attorney Eric Holder stepped on some toes when he said we need to talk more. But he was absolutely right.
Within short span, we have two examples of racial ignorance----one from the nation's largest city and another from a city that is only 2-1/4 square miles.
Let's start with the mayor of Los Alamitos, CA., a tiny town in Orange County.
Mayor Dean Grose was forced to apologize after it was reported he sent an e-mail out to colleagues and business people--including a black woman who serves on a committee with the mayor--that depicts the White House lawn planted with watermelons.
I'm not sure how Grose expected people to respond, but African Americans don't find watermelon jokes funny. All you have to do is research racial stereotypes to understand why. The smiling "darkey" eating watermelon was a popular image during America's racist past, and was the one of the stereotypes used by Obama-haters during the presidential campaign .
Grose claims he was "unaware of the stereotype that black people like watermelon," and didn't mean to "offend" African Americans.
But you don't have to be from a small town to be ignorant about offensive stereotypes.
New York Post owner Rupert Murdoch was forced to give a rare apology after a racially offensive political cartoon sparked daily protests outside the newspaper's offices. The cartoon depicted two New York cops shooting a chimpanzee. The cartoonist linked the rampage of a chimp that tore off a woman's face to the creation of the stimulus package.
Murdoch and the cartoonist both claimed not to know the monkey has long been used as to disparage the intellect and humanity of African-Americans.
Just about any black person on the street could have told these white males they were about to set off a firestorm.


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Originally posted on The Hockey Guys | Last updated 4/5/12
Pavel Datsyuk confronts Paul Gaustad and Ryan Suter on March 30, 2012 at Joe Louis Arena By Rhys Richards (@RREsq) Last Tuesday, the Detroit Red Wings and their fans celebrated the 15th anniversary of the team's brawl with the Colorado Avalanche at Joe Louis Arena with a 7-2 drubbing of the Columbus Blue Jackets at home. That famous bloodbath pitted Igor Larionov against Peter Forsberg, Brendan Shanahan against Adam Foote, and Mike Vernon against Patrick Roy. With all of those well-known players in the mix, the brawl is still remembered most for Darren McCarty pummeling Claude Lemieux until Lemieux turtled. As the fifteen years have passed, the vast majority of the players on both teams have retired from the game. As those players went, so did the Detroit-Colorado rivalry. Detroit's success in the past two decades means that the Red Wings regularly see all other NHL teams at their best, but Detroit has been waiting for another team to take Colorado's place as its fiercest rival. D...
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Thankfully, given that Hoot's plot, pacing, and acting are so sub-par that even a made-for-Nickelodeon movie would be ashamed of it, it's not likely to make much of an impact at the box office. And after attending the junket for the film in Fort Lauderdale, I found other reasons to feel reassured that this film's message won't take much hold in the hearts of adolescents, since it doesn't appear that it was even able to fully persuade its own young cast.
Questioned whether she feels as compelled as her character to take a stand for undeveloped land, 16-year-old Brie Larson (Beatrice) reveals a level of sense many adults in her industry lack: "Depends on the area—on whether its just a flat piece of earth or if its something that really seems important to society…I mean, I wouldn't go somewhere and go, 'yeah, take a stand' if I didn't know anything about it."
And while 16-year-old Cody Lindley describes his character, Mullet Fingers, as an outlaw willing to overlook the rules for a greater good, when asked what might motivate him to such activist lawbreaking, Lindley replies, "Well, I wouldn't feel that way for owls, but if someone were trying to hurt my family, I don't think I would follow all the laws."
Lindley expresses similarly down-to-earth feelings about his native country: "I know everyone talks about how bad it is here, but overall, I'm kind of optimistic. I'm so glad to live here [in America] because compared to the rest of the word it's really great, and I don't think there's a lot that's immoral and bad about America compared to the rest of the world."
Despite Hollywood's best liberal programming efforts, it appears that the kids, at least these kids, really are alright.
Megan Basham is the author of Beside Every Successful Man: A Woman's Guide To Having It All
Be the first to read Megan Basham's column. Sign up today and receive Townhall.com delivered each morning to your inbox.
Rush Limbaugh defends Rubio's debate answer: He's absolutely right that Obama knows what he's doing | Allahpundit
Time for Team Hillary to break out the gender card for young liberal women who prefer Sanders | Allahpundit


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Published on Sep 30, 2009
A great place to start when planning a community.
Be the first to comment
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Clipping is a handy way to collect important slides you want to go back to later.
Clipping is a handy way to collect and organize the most important slides from a presentation. You can keep your great finds in clipboards organized around topics.
Looks like you've clipped this slide to already.


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The Case of the Mysterious Author Who Took Her Children to Bookstores all over the Country
Jenny Milchman, you are either the coolest mother this side of the Pecos, or a completely crazy woman, possibly both.
Milchman, who recently published the suspense novel "Cover of Snow" (Ballantine), is driving around the country visiting independent bookstores to promote her novel -- with her husband AND their two children. "During the tour, we are 'car-schooling' our first- and third-grade children. Part of their education will be seeing the landscape change as the bookstores do," Milchman, who lives in New Jersey, wrote in an article for the bookseller trade e-newsletter Shelf Awareness. »Read Full Blog Post
Big-time jazz returns to Milwaukee
There was a time when widely known jazz stars included Milwaukee clubs and concerts on the music's national circuit. That ended decades ago, but there's a brief revival of sorts this week.
At 8 p.m. Friday, the Gerald Clayton Trio performs in the adventurous Alverno Presents concert series at Alverno College's Wehr Hall, 4100 W. Morgan Ave. »Read Full Article(1)
Museum of Wisconsin Art opens new building
After researching and refining the history of Wisconsin art for decades, the Museum of Wisconsin Art will be able to tell more of its story starting this weekend. It will reopen in a dramatic new building nestled on the Milwaukee River at 205 Veterans Ave., West Bend - a gleaming, white wedge with twice the space for art inside.
The museum also is altering its narrative, opening up what it means to focus on "Wisconsin art" and creating a greater focus on contemporary art. »Read Full Article
Discovery World baseball exhibit opens on opening day
It began in 1845 with the invention of the modern baseball field. It continues with the Brewers' home opener Monday with the retractable roof at Miller Park.
Baseball has embraced change and new technologies all through the history of the sport. Now baseball fans can get a sense of that evolution at the new Discovery World Museum exhibit: "MEARS Presents Baseball - Innovations That Changed the Game." »Read Full Article
Big Sean fumbles the flow at Rave show
Even the most dedicated hip-hop fan might have to admit that rap shows are not usually known for their excellent pacing.
Songs die just as they're getting started; shout-outs take the place of choruses or, although this is rarer, the performer follows a whim and recruits female fans to compete in an informal contest of callipygous qualities. »Read Full Article


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Here's a final update and word of thanks about the project to gather backpacks and school supplies for children in need who attend Samuel W. Tucker Elementary School.
I just wanted to take a minute and express my gratitude towards everyone who supported this effort. Whether you supported us through donation and/or prayer, it is because of your efforts that I am able to say that we were able to fill 24 backpacks with extra supplies to donate.
The backpacks are filled with at least one of every item that was on the supply list, as well as a small gospel tract and information card about Grace Church of Alexandria. These backpacks and supplies will go straight to kids in our community in need attending school at Samuel W. Tucker Elementary.
We will directly touch well over 24 students, but through your actions and love, we will touch countless families, teachers, and staff at Samuel Tucker. So, thank you, thank you for your participation and support. I pray we will be able to do this again next year.
~ Dominique Johnson, Project Coordinator
Escape From Slavery
Across the street from Whole Foods in Old Town Alexandria stands a statute in tribute to Emily (age 13) and Mary (age 15) Edmonson, courageous African-American sisters who tried in April of 1848 to escape their bondage as slaves. As I retold last Sunday at Grace Church of Alexandria as an illustration for that day's sermon, the Edmonson sisters were born into slavery, yet they yearned for freedom. They secretively boarded a sloop on the Potomac River called The Pearl, led by sailors sympathetic to slaves who wanted to escape to liberty.
Statute of Emily & Mary Edmonson in Alexandria, VA
As The Pearl set sail from the District of Columbia, a steamboat filled with furious slave owners gave chase and captured the sloop with 76 slaves in the cargo hold, including the teenage Edmonsons. This turned out to be the largest escape attempt by slaves in American history! The poor slaves were locked up in Alexandria at the infamous Bruin slave jail at 1701 Duke Street. Emily and Mary were paraded on the slave market by slave trader Joseph Bruin who sought to sell them for sexual exploitation to the highest bidder. Their father, a freeman, sought desperately to gather funds to redeem them from the slave market but could in no way afford the extravagant sum for which his young, attractive, daughters were selling for on the market.
Praise be to God, a church in Brooklyn heard of the sisters' plight and contributed the money to purchase their freedom. Mary and Emily were set free! A writer named Hariett Beecher Stowe told the story of their slavery and capture during their escape attempt in her book The Key to Uncle Tom's Cabin. The account of Emily and Mary's abuse and bondage spread across the country and helped stir up sympathy to free the slaves. The sisters ended up becoming friends and helpers of Frederick Douglass in his campaign to end slavery in America, and Emily's relatives ended up helping to start two Christian churches in D.C.
A Call For Justice
I am sobered as I consider how deeply the evil of human slavery has stained our city's history. The statute of the Edmonson sisters is a constant reminder of the depravity of the human heart and a call for Christians to pursue justice and stand for the oppressed.
Social action is not the gospel, yet it flows as a consequence of the gospel. Christ set us free from the grip sin held upon us, and he now calls believers to love radically like he has loved.
We value justice because Scripture is replete with statements that make clear God values justice for the oppressed who are made in his image. We ought to take seriously His call to care for "widows, orphans, and stranger in the land" (such as Leviticus 19:33 and Jeremiah 7:6) and "to care for orphans and widows in their affliction" (James 1:27). And we value justice in this world because pursuing justice now gives us the chance to display what it looks like to live under God's gracious rule, when Christ will soon usher in his kingdom in its fullness.
Justice–There's An App For That
We are grateful for Christian organizations like International Justice Mission, based near Alexandria (IJM), that organize Christians to fight modern-day slavery, sex trafficking, and other forms of injustice. Last month IJM released an app for iPhone, Android, and Windows Phone 7 that includes updates from the field, stories of justice, and tools to take action–
IJM_App from Fire Tribe Productions on Vimeo.
Grace Church of Alexandria regularly informs our members how they can stand for justice for oppressed Christians and human beings throughout the globe, first by carrying the good news of salvation in Christ to the ends of of the earth and then by praying for and advocating for the oppressed.
This post was written by Jonathan Matías and Garrett Lee, pastors of Grace Church of Alexandria.
Project: School Supplies For Samuel W. Tucker Students
May 27th, 2015
We will be collecting backpacks and school supplies for Samuel W. Tucker Elementary School students in need. We are grateful to be able to meet in the school for worship on Sundays and would like to give back to the school community.
Collection dates: from May 31 to July 5.
List of supplies: at the Welcome Table on Sundays or email the church to request it. Monetary donations are also accepted. You can gather a full backpack, or a dozen of the same needed item (erasers, for example), or whatever combination you'd like.
To Donate: Please put your donations in the plastic bin at church or give directly to project coordinator Dominique Johnson.
Thank you for helping to give back to our community!
Race, Cross, and The Church: Toward a Biblical Theology of Race
August 17th, 2014
This Thursday August 21 is a historic day in Alexandria history. It's the 75th anniversary of the Alexandria Library sit-in led by Samuel W. Tucker, what is believed to be the first civil rights sit-in in American history. On this occasion, our lead pastor Jonathan Matías retold Samuel Tucker's story and preached a synopsis of what the Bible says about race.
Listen by clicking the play button below, and follow along with this visual presentation.
Race, Cross, and the Church: Toward a Biblical Theology of Race by gracealexandria
Sermon Title: Race, Cross, and The Church: Toward a Biblical Theology of Race
Sermon Text: Genesis 1:26-28, 8:13-17; Ephesians 2:11-22; Revelation 7:9-10
Read more about the historic sit-in here and here.
Click the link below to listen to an audio recording of the sermon.
Podcast: Play in new window | Download
Author of Tangible to Speak at GCA Sunday 11.17.13
November 12th, 2013
Chris Sicks, NavPress author and pastor in Alexandria, will be preaching about mercy ministry at 10:30 am on Sunday November 17, 2013, at Grace Church of Alexandria. Join us at 10:30 am to hear Chris–an engaging, thoughtful, compassionate believer–share how we can make God's gospel love tangible to people in our city.
Chris has an incredible story of grace to tell, about how God has led his church Alexandria Presbyterian Church to have a powerful ministry to refugees in the Washington D.C. area, which has opened up countless doors to witness. Read the story here.
As I've gotten to know Chris, by his life I've been personally challenged to reassess how I should more actively and lovingly care for the physical needs of people in my life. By sacrificially meeting physical needs, this opens up doors to speak the truth of the gospel to hurting hearts. Chris has challenged me–what he would call a "word" person"–t0 also be a "deed" person, to make God's gospel love touchable and real to people, so they will be more open to the saving message of Christ. As Chris says,
"I find it fascinating that Jesus chose to help hurting people as the most frequent proof of his divinity. He could have commanded the sky to rain or snow, moved mountains, and turned rocks into diamonds. These acts would have demonstrated his divinity as clearly as healing and feeding did. He once calmed a storm on the Sea of Galilee, but even then his attention was on the terrified men in the boat. Jesus' heart of compassion was always moved by people and their needs."
– p. 30 from Tangible
Chris's book Tangible is available from NavPress and will be for sale at Grace Church on November 17th. Here's the print version and the Kindle version. I invite you to come hear Chris!
Evening of Prayer For Our City, Sun, Oct 6
September 4th, 2013
Seek God's grace for Alexandria.
Meet like-minded Christians.
Come hear a devotional on prayer.
Grace Church of Alexandria is gathering with other gospel-centered churches to pray for our city.
When: Sunday, October 6, 6 pm
Where: Franconia Baptist Church
5912 Franconia Road, Alexandria, Virginia 22310
Details: ahumbleattempt.wordpress.com
Children: Stay tuned. Childcare may be provided for kids up to age 3.
We love our city, and praying for the good of our community is one way we can express our love and make a difference. As Jeremiah 29:7 encourages–"Seek the good of the city" where God has planted you.
Come join us!
- Grace Church of Alexandria
- Franconia Baptist Church
- Franconia Korean Baptist Church
- Iglesia Biblica de La Gracia
- Woodlawn Baptist Church
- Grace Baptist Church of Arlington
- Good News Baptist Church
Samuel Tucker: Civil Rights Leader & Namesake of GCA's Meeting Place
August 28th, 2013
Who Was Samuel Tucker?
Each Sunday Grace Church of Alexandria meets in a building named the Samuel W. Tucker Elementary School. Who was Samuel Tucker? Why is our city honoring him this week with a series of commemorative events?
Unsung Civil Rights Leader
Samuel Tucker was an African-American lawyer in Alexandria who brilliantly organized the nation's first sit-in right here at Alexandria's public library to protest discrimination against African Americans. Long before the civil rights movement adopted sit-ins as a key tactic to overturn racism, on August 21, 1939, Samuel Tucker sent five African American teens to stage a sit-in in our public library, where it was illegal for black people to enter. As expected, they were arrested by the Alexandria police. Attorney Tucker then defended them in court and used their case to secure a new public library for African Americans who, until this time had no access to a public library.
We take seriously the Bible's command for believers to "Speak up for those who cannot speak for themselves; ensure justice for those being crushed" (Proverbs 31:8). Because of this, we take great pride in the fact that our church's meeting place is named for this noted civil rights leader who helped pursue biblical justice in our community.
Commemorative Events This Week, Aug 25-31, 2013
In honor of Samuel Tucker, the Alexandria Black History Museum is offering:
- $1 DVD – "Out of Obscurity" – the story of the first sit-in in America, led by Samuel Tucker. Copies are available for $1 at the Alexandria Black History Museum. Screenings of this engaging film are taking place today, August 28, at 1, 2, 3, and 4 pm at the museum.
- Civil Rights Walking Tour – A free tour on Thursday, August 29 at 12:30 am and 7:00 pm exploring important sites related to Samuel Tucker and Alexandria's historic 1939 sit-in. Sponsored by Virginia Tech.
Can't make it on the tour or film showing? Drop by the Kate Waller Barrett Library at 717 Queen Street in Alexandria where the sit-in took place. Visit the Alexandria Black History Museum. Or watch this C-SPAN video about the 1939 sit-in.
Did You Know There's A Church in Cameron Station?
August 27th, 2013
That's right! A gospel-centered church meets right in Alexandria's Cameron Station–Grace Church of Alexandria. For five years we've been meeting at Samuel W. Tucker Elementary School on the far end of Cameron Station. Come join our church family for worship at 10:30 am on Sundays! You'll find a warm welcome, grounded Bible teaching, and a place to learn about Christianity.
This fall you may notice these posters, announcements, and web ads in Cameron Station, introducing you to Grace Church of Alexandria. Drop in and consider making Grace Church your church home! Our six community groups meet in Alexandria and surrounding communities. And if you're new to Christianity, we invite you to come and learn what the Christian message is all about.
Location Change: Sunday Aug 25 is Church in the Park
August 20th, 2013
On September 1, 2013, Sunday services will be back at our regular meeting place, Samuel W. Tucker Elementary School.
Sunday, August 25, 2013
10:30 Service
11:30 Lunch
Afternoon – hang out at the park
Where: Instead of our regular meeting place, GCA will meet at:
Ben Brenman Park
The pavilion across the footbridge
Deer Run Court, Alexandria, VA 22304
Download and print a map here: Map from GCA to Park Pavilion
Casual church service including singing, devotional, and testimonies.
Free Lunch!
GCA will provide subs for everyone. Sign up to bring sides, dessert, and drinks.
What About Kids?
• Childcare will be provided for walkers (kids who can walk & play).
• Two pack-n-plays will be available at the pavilion for infants.
• Check in your walkers before the service begins, then they'll be dismissed after the song service to go with GraceKids workers to the nearby play area.
• Crayons and coloring sheets will be available during GraceKids check-in.
Bring a volleyball, frisbee, soccer ball, board games and stick around for fellowship!
Inclement Weather
In case of bad weather, we will meet at our regular meeting place:
Samuel W. Tucker Elementary School
435 Ferdinand Day Drive, Alexandria, Virginia 22304
This change would be announced on Saturday via church email, GCA web site, and Twitter.
Gather to Pray For Alexandria, This Sunday, 6/30, 6 pm
June 25th, 2013
Come join other gospel centered churches in Alexandria and Arlington to pray for our community. This joint prayer meeting for God's work in our area is called "A Humble Attempt to Unite In Prayer." Consider meeting with Christians from other churches to seek God's grace on Alexandria and Arlington.
When: Sunday, June 30, 6 pm
Where: Grace Baptist Church of Arlington
700 S Buchanan St Arlington, VA 22204
Details: ahumbleattempt.wordpress.com
Children: Childcare will be provided for kids ages 0 to 3
Wondering where the title came from? It is drawn from a treatise on prayer by American theologian Jonathan Edwards.
Come pray for Christ to be glorified in our area!


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Welcomes You
Maytown Garden Tour
Saturday June 20, 2015
The Maytown Historical Society has had that Spring-like vision in view, as plans have been made to host another garden tour in our fabled and beautiful village on Saturday, June 20, 2015, from 9:00 AM until 4:00 PM.
On that day, rain or shine, ten or more varied town gardens---many with ponds and other special features-will be open to the public; talks and presentations will be given at various sites on diverse gardening subjects; and, of course, delicious foods will be available for breakfast, lunch, and snacking.
MHS stalwarts and noted "green thumbs", Carol Eddins and Susan Corridon, will host an expanded plant sale at their 9 South River Street Victorian home and large garden, with as many as 300 potted and varied perennials for sale at a reasonable price of $4.00 each.
Early risers may dine in the lush backyard of the town's museum, beneath canvas pavilions, on our famous breakfast sandwiches that combine eggs with ham, cheese or bacon, from 8:00 AM until 10:00 AM; and, from 11:00 AM onwards, a larger menu will be offered, consisting of hot dogs, burgers, bratwurst, sliced barbecue chicken, potato salad, baked beans, sauerkraut, and a variety of beverages and desserts---including among the latter, fresh strawberries paired with ice cream or pound cake!
The museum, of course, will be open to view our continued display of many of the most-prized artifacts in our collection, and a table will be set up in the yard to sell some donated items and excess gift shop inventory.
Tickets for the garden tour cost $8.00 in advance and $10.00 on the day of the event. Call Gordy Nell at 426-2786 to procure the tickets in advance.
Profits generated by the event benefit the work of the Maytown Historical Society in this, our 30th year. We thank you for your support in helping us to keep our special town's history and cultural life alive and well for these many years, and invite you to not only be a patron of our special events but also a member of our Society. Join us on most second Thursdays of the month, at 7:00 PM, at St. John's Lutheran Church, 11 North Queen Street, in Maytown. Sponsors of this year's Garden Tour include: Longwood Manor, Donegal Insurance Group, Union Community Bank and several anonymous sponsors..."Thank you"
Breakfast & Bake Sale
Saturday March 21, 2015
Breakfast tickets are $6.00 and can be purchased prior to March 21st by calling Gordy Nell at 717-426-2786, tickets will also be available at the door on day of breakfast.
October 18, 2014 -- from 10:00 AM until 5:00 PM
Last year, the Maytown Historical Society hosted a Winterfest in December which, while a nice idea, was not as successful as the previous year's effort, due to very cold weather and an afternoon snow storm. Vendors complained about the cold or failed to show up at all, due to the forecast, and local people didn't turn out as well as expected. For those reasons, the MHS is offering the community a major event in a different time of year that is less subject to poor weather and full of autumnal beauty.
On Saturday, October 18, 2014, from 10:00 AM until 5:00 PM, the town will host an event that celebrates the heritage of Maytown's most predominant ethnic group---the Germans! The MHS will sell a variety of German foods at a stand on the northeast tangent of the square, including, of course, pork and sauerkraut, bratwurst sausage, German potato salad, and baked goods such as Black Forest Cherry Cake, apple strudel, rich, chocolate Sachertorte cake (a layer cake named after the Hotel Sacher in Vienna), shoo-fly pie, Lebkuchen (gingerbread), and many more offerings donated by the populace---washed down by a variety of beverages including root beer and perhaps even a bottle or two of near-beer---to name but a few.
Diners may sit at tables in the middle of the decorated square (Maytown's version of a Biergarten without the alcohol) while they are entertained by the German ensemble of the Bainbridge Band and a troupe of folk dancers from the Lancaster Liederkranz. They can also view a collection of souvenirs from Germany and Austria that town citizens have accumulated from their travels---and we hope to have students from Donegal High's German Club take part in the festivities. Keith Smith, St. John Lutheran Church's organist of 40 years will play the music of Bach and other German composers on the church's organ from 2:30 PM until 3:00 PM.
We are, as well, seeking out commercial vendors who would be willing to sell German-related foods such as soft pretzels and funnel cakes etc., as well as crafts often found in Germany's famous pre-Christmas markets called Christkindl fairs.
At the same time that all this is going on, the museum , at 4 West High Street, will be open for the public to view treasures from the MHS collection of artifacts as well as patronize the gift shop for Maytown souvenirs, German redware dishes, and Byer's Choice figurines.
And if that weren't enough, the Society is also sponsoring, that same day and time, a Fall Haus Tour that costs $8.00 in advance of the day or $10.00 on the day itself. One may visit 9 different town homes---plus three of our historic churches---the Lutheran, Reformed, and Church of God buildings.
Houses on the tour include Jack Frank's magnificent federal style dwelling; Victorian houses owned by Vernetta Wallander, Susan Corridon and Carol Eddins, and new Maytowners, Bob and Eileen Swartz; the historic Lutheran parsonage with its ties to Simon Cameron and the iconic Haines House on the Square; and the new house owned by Jack and Donnis Young, the newly re-purposed house/tobacco warehouse owned by the Stiver family, and the newly-rebuilt house of Ginny Emswiler, which arose, like the phoenix, from the ashes of a 2013 fire.
So circle your calendars and be prepared to come out on October 18th, from 10 AM till 5 PM to celebrate Maytown's past and present and have a good time doing a good thing---helping to create and renew our community's spirit and resist the danger of just being a bedroom community---which is no community at all!
Questions may be addressed to Bob Lescallette at 717-426-1643 or via the MHS website, www.maytownhistory.org.
House tour tickets can be obtained ahead of time by calling Pat Vogel at 717-426-2360 or leaving a message on the museum phone, 717-426-1526. You can help by patronizing the event, publicizing it among your family and friends, donating food to sell, loaning German souvenirs to display, or working at the food stand or in set-up/take-down activities.
Breakfast & Bake Sale
Saturday March 22, 2014
Breakfast tickets are $5.00 and can be purchased prior to March 22nd by calling Sue Nell at 717-426-2786, tickets will also be available at the door on day of breakfast.
Maytown Winter Festival 2013
Maytown Historical Society presents an Open House Tour featuring Six Homes in addition to our Winter Festival on Saturday December 14, 2013. Tour hours are 11:00AM - 5:00PM Tickets for this event are $8.00 in advance or $10.00 day of tour. Advanced tickets can be purchased by calling 717-426-2786. On the day of the tour, tickets may be purchased at the Maytown/East Donegal Museum located at 4 West High Street. A special addition to the Open House Tour this year will be Dolores Hackenberger, lovingly referred to as the Grandma Moses of the Pennsylvania Dutch Country She will be demonstrating her painting in one of the homes featured on the house tour.
Sponsors of this year's Festival and House Tour include: Engle Printing and Publishing, Longwood Manor, Donegal Insurance Group, Union Community Bank and several sponsors who wish to remain anonymous. "THANK YOU"
Maytown Winter Festival 2013
Third Annual
The Maytown Historical Society is planning a third Maytown Winter Festival to be held on Saturday, December 14, 2013, from 10:00 AM to 4:00 PM. The event seeks to promote community holiday spirit, and it affords people the opportunity to purchase unique Christmas and other gifts as well as sample a wonderful variety of foods---while being entertained by an array of performers and costumed characters. It also raises funds for the support of the MHS, which is an all-volunteer group of people who operate a small museum, amass town artifacts, and further the appreciation of Maytown's history and cultural life.
On the 14th, the village square and High Street will be lined with vendors selling a variety of wares. A costumed town crier and a Belsnickel (a folkloric figure associated with Christmas among the early German settlers) will flavor the scene, as will wandering carolers and other musical ensembles.
At the c. 1800 Haines House, currently occupied by MHS stalwarts, Dan and Rene Plummer, one will enter into a colonial atmosphere Royal George Inn and be served fine desserts and beverages at linen-covered, candlelit tables, by costumed waiters and wenches.
Or, one may choose to walk a short distance down South River Street and patronize The Sister's Ye Olde Bake Shoppe, where you may purchase delicious apple dumplings, cookies, and other pastries in a Victorian setting presided over by MHS pillars, sisters, Carol Eddins and Susan Corridon.
If you haven't yet been fully fed by material food---how about stopping by the Maytown - East Donegal Museum at 4 West High Street, and feast on our town's history? This year's display remembers the incredible life of our most famous native son, Hon. Simon Cameron, who was born in a Maytown log cabin that once stood but a few paces to the west of the museum, in 1799, and who rose to be one of the most powerful and influential men in nineteenth century America! You can read a time-line of Cameron's life, view lots of photos, be startled by a life-like, dressed mannequin of The General himself, read some of his wittiest statements and those written about him, and even view several items that actually belonged to the great man---some of which are on special loan to the MHS from sister societies in Lancaster and Harrisburg.
The museum also boasts a fine gift shop where you can purchase gifts ranging from pottery, textiles, and smaller souvenirs of town to a huge variety of Byer's Choice figurines---many of which wear Christmastide-Dickensian attire!
Maytown's beautiful and historic churches will be open for tours, displays, and special holiday programming and this year's festival may feature additional venues which are still in the planning stage and may be announced via future publicity.
So travel back in time to a magical place called Maytown, USA to get caught up in the Yule-tide spirit---and support efforts to preserve and expand the quality of our life together!
250th Anniversary Commerative DVD
A commerative DVD of Maytown's 250th anniversary celebration has been produced by the Maytown Historical Society. Using several hundred still photos and video recordings from local residents, every aspect of the 4 day celebration has been recorded and transformed into this commerative DVD.
If you were here in Maytown and enjoyed the celebration, this is a great way to preserve those wonderful memories, and a part of Maytown history. With a price of $21.20 each (which includes PA sales tax), they make a great souvnier for yourself or pick several up for gifts. The DVD's are available for sale at the Maytown-East Donegal Museum.
In 1985, a group of citizens banded together to form the Maytown Historical Society. The immediate motivation for establishing the society was the celebration of the 225th anniversary of the town's founding.
With that accomplished in fine style, the society began a more routine, but ultimately more important life of collecting local artifacts, amassing, sharing, and recording historical data.
The society hosts a wide variety of events and fund raisers including the annual "Mayfest" celebrations, as well as monthly programs to raise the historical consciousness of our local population.
In 2002 the Society took a bold and significant step: we saw the realization of a 17-year dream, by purchasing a site for our museum. This log structure may be the oldest structure in the village, likely dating from 1760.
Maytown/East Donegal Museum
The purpose of the Maytown Historical Society is to develop and maintain a continuing, written history of Maytown and East Donegal Township, Lancaster County, Pennsylvania.
To seek, acquire/loan and preserve all documents, artifacts and other mementos which exemplify lifestyles and or events of historical significance.
To research, classify and document pertinent information on buildings and to promote the preservation, restoration and registry of such buildings.
To determine the role of Maytown and East Donegal Township in world, national, regional and adjoining area history.
To present programs and events which will be informational, educational and interesting to the members and general public.
To advocate for government policies, ordinances and laws that preserve our historic buildings, farmland and community character.
Since the Maytown Historical Society is a non-profit organization, donations of artifacts may be deducted from income taxes at their appraised value---just as cash donations to the Society may be deducted. If you have questions about this, or are contemplating making a donation to us, please feel free to contact me, the MHS Archivist (Jack H. Frank) at 717-426-3308
Old family photos, histories, diaries, deeds, maps and other documents will be accepted, along with artifacts and materials from citizens, businesses, schools, churches, political parties and other organizations---insofar as the items relate to the Maytown/East Donegal Township Community.
General meetings are held on the second Thursday of each month
PO Box 293
Maytown, PA
Along the Susquehanna
Lancaster Historical Society
Register of Historical Places
Winters Heritage House
Marietta Restoration Assoc.
Mt Joy Historical Society


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Grant Programs
Since the Foundation's inception, more than 2,500 grants awarded to artists and arts organizations—totaling over $11 million—have provided opportunities for creative exploration and development. FCA supports individual artists and collectives working in dance, music/sound, performance art/theater, poetry, and the visual arts through five grant programs: Grants to Artists, the John Cage Award, the Merce Cunningham Award, and Robert Rauschenberg Award, and Emergency Grants.
In 2015, the Foundation for Contemporary Arts is poised to distribute $740,000. Fourteen Grants to Artists of $35,000 each were awarded in January—a total of $490,000. Additionally, a $35,000 Robert Rauschenberg Award and the inaugural $35,000 Merce Cunningham Award were made. $40,000 was disbursed in Contemporary Visual Arts Scholarships and FCA is on track to distribute $140,000 to more than 100 artists through Emergency Grants.
FCA does not consider requests for funding outside of program guidelines; Emergency Grants is the only program that accepts applications. Unsolicited submissions of work samples or other materials will not be returned. Thank you for understanding.


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Healthy waterways for a healthy economy...
The waterways of South East Queensland are an integral part of our lifestyle and economy. With a rapidly growing population and increasingly unpredictable climate, our waterways are under increasing pressure from threats such as soil erosion, stormwater run-off, litter and land clearing.
Healthy Waterways is an independent, not-for-profit organisation working to protect and improve our waterways. We have a renowned collaborative model consisting of strong community, industry, government and research partnerships working together to achieve healthier waterways that underpin a healthy community.
Healthy Waterways works to understand and communicate the condition of the waterways to drive and influence future targets, policy and actions. We monitor and report on waterway health, educate on the value of our waterways and support reforms to policy and planning where it will benefit our waterways and community.
We all have a role to play in protecting our waterways to safeguard the future of our environment, economy and community. Get involved with Healthy Waterways today and together, we can make a difference.
Newly evolved Report Card released
The newly evolved Healthy Waterways Report Card reveals the condition of South East Queensland's waterways and introduces a new Waterway Benefits Rating.
Community & Education
Discover the value of our waterways and what you can do to help protect this precious resource.
Planning & Development
Browse our range of tools, resources and initiatives driving the sustainable management of urban water.
Science & Research
Understand the condition of our waterways and learn about our science-driven approach to waterway management.
Featured News
Do you know a waterway champion?
02 February 2016
As we make our way into 2016, it's a good time to think about the many people in our communities who are on the ground working to keep our waterways clean and healthy for our enjoyment.Read more
Inspire your community to Connect to Your Creek
02 February 2016
South East Queensland groups, organisations and individuals are encouraged to host an event as part of Healthy Waterways' Connect to Your Creek Week from 9 to 17 April 2016.Read more
Empowering people to choose to reuse
02 February 2016
Healthy Waterways is further empowering people to choose to reuse by making the reusable water bottles from our Water on Tap® machines available for purchase on our website.Read more
Calling all Scenic Rim teachers
02 February 2016
There is still time for primary school teachers in the Scenic Rim area to take part in the 2016 teacher training workshop for Healthy Waterways' award-winning storythread education unit, Up the Creek and Down the Drain.Read more
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Healthy Waterways gratefully acknowledges the support of our members and recognises the valuable contributions and investment they make towards protecting and improving South East Queensland's waterways.