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This is an excerpt from my Master's thesis titled "Erotic Embodiment and Integration of Soul, Spirit, and Body: Toward a Sacred Erotic Psychology Healing Praxis," it is a piece from the Introduction
To say it is difficult to write about embodiment is an understatement. Writing is a tool of the mind and splits us off from bodily experience. Language cannot fully capture the essence of being embodied, of being in a body, or of bodily sensations and emotions, but it can try. For the most part, language brings us out of our bodies and puts us apart from ourselves, especially language in an academic framework where one is compelled to be aware of sentence structure, word choice, proper citation methods, and so on. The question of how I can write an academic work on embodiment is one I have been grappling with since before I began writing it. The language that most closely aligns with the body is imaginal and poetic. With exception of the praxis chapter, my use of poetic imaginal language has been limited. I have not engaged with the imaginal and poetic nearly enough. Here is an attempt.
I really value each of the realms of spirit, soul, and body and the various ways they each manifest in the world, and I know that of these three realms the body is the most denigrated. This culture has a body problem. It has a problem in all three realms, really, but the way we approach the body is so much more backwards and twisted in my experience. We do everything we can to avoid focusing on our bodies, and that includes me. I have spent a lot of my own life hating my body, treating it as separate from my essential self, or ignoring its needs, feelings, and warnings.
My body has stiffened from the chore of sitting in front of a computer, writing (or attempting to write), while fighting against all the internal blocks I have against doing this work, my work. I can feel it in my shoulders and the back of my neck in the tension that creeps its way up and down from my head to my lower back. I get hit with it when I stretch, arching my back to hear the cacophony of crunchy popping sounds as my vertebrae realign themselves, and suddenly the release of tension sends a momentary throbbing spiraling up all the way to my temples. I can feel it in my knees and hips, the way I hold myself as I walk, where on my feet I place emphasis. I can tell when I am resisting the process and when I am not coming to my work with all of my strength by the way that I sit, passively and slouched or tall and engaged. I can feel it in how I am holding my teeth and tongue, the crack of my jaw when I yawn, the bend of my left knee when I take a step (am I fully bending it, or dragging that foot as I move?), or the pop of my right ankle when I get a twinge or stiffness in it that needs to be rotated out. My body tells me things, and I choose to listen to it or not, though the more I do this work the less I can ignore it. I notice the tension, I breathe, I move.
I do not claim to be perfect at my own methods, or to have mastered embracing the theories and praxis described in this thesis. In fact, what is driving me to do the work that I am dedicated to doing in the world, the work that this thesis is but a fraction of, is my own struggles with embodiment, connection, and belonging. I have been experiencing my own process as I have been writing about it, articulating only as far as I have been able to traverse my own self. Thus through this process I have had to feel my way through it just as much as I have had to work my way through it. I have had to nurture my own self, to build up the strength and self-love and self-compassion. To bring awareness to the things that I do, conscious and unconscious, and the patterns that I am enacting and reenacting within myself and with my lovers, friends, and family. I have gone through some major shifts and realizations within myself through this process, and also know that it is not over. This is just the beginning.
In going through this process of embracing my emotions and letting them flow, of excavating my own shadow and my own past, of working to understand the patterns laid inside of me back in the time of childhood and pre-verbal processing that still run me, of attempting to experience exquisite embodiment of the Self that is called Tai in this incarnation, I have had to confront most if not all of the parts of myself that keep me back. My self-sabotage. As with everyone, all of my issues are interlocking, threads in the tapestry of my life that interact and intersect, not just discrete problems that can be approached completely independently of each other. I have had to face head-on my own fear, grief, shame, anger, some nasty patterns of internalized oppression and repression. I have had to confront my fear of taking up my own space and what it looks like to put something so large as a personal sacred erotic manifesto into the world. This work details the entirety (so far) of my life's purpose and my understanding of spirituality, sexuality, psychology, and their interactions with each other, and I am really taking up my own space by declaring my own mastery of it. I have also had to process and move through the grief I experienced surrounding the very sudden death of my father, and the emotional and psychological patterns instilled in me generationally and personally through him. I have recognized the shame I have held on to around being my true authentic self in a society that reviles people like me in multiple intersections of my identity. I have had moments of intense jealousy and shame around my relationship with my primary partner, and due to our interlocking patterns around intimacy and attraction we have, on occasion, fallen down the rabbit hole of destructive behavior.
Shame has been a large factor in my excavation process, and shame is necessary to face when doing this work. Emotions are necessary to face when doing this work of the body. To this end the work of Brene Brown and Karla McLaren have been indispensable to me. I have realized the amount of emotion processing that goes on in the face of change, and know that is a vital aspect of becoming. All emotions are particularly powerful, necessary, and important. They each have a reason for coming up when they do and a particular purpose or gift to share with us, if we are open to them. This entire thesis process has been an emotional one, and has impacted my body as such.
This is an exerpt from my Master's thesis titled "Erotic Embodiment and Integration of Soul, Spirit, Body, and World: Toward a Sacred Erotic Psychology Healing Praxis," it is a piece from the Theoretical Foundation chapter, Sacred Eroticism as Ontology section.
To further understand the self-deepening and embodied feeling inherent in the erotic, I turn once again to Audre Lorde1, who wrote:
[The erotic] is an internal sense of satisfaction to which, once we have experienced it, we know we can aspire. For having experienced the fullness of this depth of feeling and recognizing its power, in honor and self-respect we can require no less of ourselves. . . . the erotic is not a question only of what we do; it is a question of how acutely and fully we can feel in the doing. Once we know the extent to which we are capable of feeling that sense of satisfaction and completion, we can then observe which of our various life endeavors bring us closest to that fullness. (p. 54)
Thus, feeling is the first step toward healing our disconnection from our erotic lifeforce and experiencing the power of the erotic. Through fully embracing our own erotic experiences of satisfaction we are given access to our deeper and full Self. Through this experience of feeling we can determine where we are numbing out, freezing, or paralyzing, and where we need to expand our experience of emotions, pleasure, and sensations. We can also discover where our passions and desires lie through this same process. This is a wholly embodied process that is also cyclical. The more we feel the more we are embodied, and the more we are embodied the more we feel.
Another natural byproduct of both individual and cultural erotic expansion is the emerging of an anti-oppressive ethic that is inherent in this type of engaging with and experiencing the world. Through this process of individual growth and becoming, we bring these developments to the culture at large. This encourages us as a culture and species also move toward sacred embodied living. An anti-oppressive ethic is referring to a life ethic, or a value-based ideology. In this instance, the value is equality, diversity, justice, and self-expression as well as opposition to suffering, inequality, and discrimination. This ethic arises through the understanding of and connection with one's higher self and soul's purpose because of the centering of pleasure, wholeness, and authenticity that occurs when embracing the erotic.
Both Lorde1 and Kraemer2 stressed the inherent experience of anti-oppression that embracing the erotic leads to. Lorde (2007) stated:
[One] important way in which the erotic connection functions is the open and fearless underlining of my capacity for joy. . . . This is one reason why the erotic is so feared, and so often relegated to the bedroom alone, when it is recognized at all. . . . In touch with the erotic, I become less willing to accept powerlessness, or those other supplied states of being which are not native to me, such as resignation, despair, self-effacement, depression, self-denial. (p. 56-58)
This shift in personal experience and willingness to oppose the programming of the culture at large is at the essence of this anti-oppressive ethic. There is a compliance and complacency that one is required to buy into when unconsciously perpetuating intersectional oppression, either outwardly or internally. This shift toward the erotic, or the shift toward understanding our own individual capacities for joy and our own sources of personal power, is a shift away from accepting the narratives of oppression and obedience ingrained in all of us from the dominant culture. Embracing our erotic natures is a move toward self-understanding, sovereignty, and authenticity. This occurs through the recognition of, acceptance of, and responsibility over one's own desires, joy, and pleasure.
The closer we are to full-bodied feeling and wholeness of Self, the closer we are to understanding our own sacred erotic natures and reason for being. This is the ultimate goal of SEP3: to assist individuals, groups, and the world toward individuation and the understanding of their soul's purpose. The particular way I go about this is through investigating the erotic, and the archetypal, mythological, and metaphorical relationships the individual has with the erotic and the body. To this end, sexuality, emotions, connection to and understanding of the sacred, archetypal engagement, past experiences, family dynamics, complexes, the shadow, personal and cultural experiences of power, and many other aspects of the Self must be investigated and integrated within the life of an individual to work toward embracing what I refer to as one's Whole Erotic Self.
- Lorde, A. (2007). Sister outsider: Essays and speeches. Freedom, CA: The Crossing Press. [↩] [↩]
- Kraemer, C. H. (2013). Eros and touch from a pagan perspective: Divided for love's sake. New York, NY: Routledge. [↩]
- SEP: Sacred Erotic Psychology, the interdisciplinary field that I am crafting/creating and working within. [↩]
I am dying. I am dying. I am dead. Pulling parts of myself away from the tangled mess I have weaved together throughout all these years. Endless pain and discomfort in the name of growth and abundance. What needs to die? What needs to be reborn? Strips of self that I have taken the time to mold out of experiences now need to be carefully separated from the rest of me, the parts that are useful stay, the parts that hold me back must go. Where do I go?
My back is hurting from stress, from the weight of the words that need to come out of me, but that I am having a difficult time getting onto the page. I cannot sit in this chair in a way that does not hurt me, it seems, in a way that keeps me embodied. I am out of my body, attempting to be in my mind only while writing about embodiment. How does that work?
I am carving out my space in the world. Bringing pieces together from culturally disparate places and creating a whole. At the same time I am digging deeper into myself and carving out spaces in my psyche where I can fit as well. I don't fit anymore. I need to take what does not work and transmute it into something that does. I take myself apart so I may be whole.
My body is uncomfortable. I have a weeks-long headache of exhaustion and perfectionism. Yes, I'm having a hard time giving that up. It's coming to the point where I do not have a choice.
I am weaving together my own ideology, my own theology, my own sacred sexology. Embracing on all the strength I have in order to focus and get this done, and it is not enough. It will be enough. Eventually it will be enough, as long as I can die. As long as I can clear this channel, get rid of this blockage, let this part of me go, it will be enough. I am enough.
My body is here. I am here. I am whole.
Instead of attempting to do a catch-up post before I write the "real" post by trying to recap all the things that have happened since the last time so many ages ago that I posted on here, I just need to write. I've been doing so much writing the last few years, but so little personal writing. Grad school has sucked up all my writing time and now that I'm writing my thesis I'm going a little bit insane. I am having a difficult time getting words down on the page, however, and I'm hoping that a bit of a free write will assist with that.
I'm struggling. As always, it seems. I have had so many epiphanies and breakthroughs and beginnings of changing long-ingrained patterns, but it never seems like it is enough. And I suppose it will never be enough, because if it was I would have nothing else to work on or nowhere else to grow. I would like a breather, however. Can't there just be a time with a bit of a relaxing, settling down, and not working on any major shit? No? Okay.
I've changed so much in the last few years, even just in the last year. I used to be terrified of, well, just about everything. Of myself. Of other people. Of getting what I want. Of my own power. I've been on a path of discovering and rediscovering my own personal power and shedding those things that have been in the way of my embracing and expressing it. My pathways were clogged for so long, and finally some bits of my own light are able to come through them and shine out of them. Still not all of them are clear, and others are gathering new gunk, but that is one of the continual processes.
Golden Dawn spiritual work, grad school, my father's death, relationship changes, explorations in polyamory, coming into my own as a Hierophant and High Priestess, all these things have shifted and changed me internally to the point of sometimes I actually realize how strong and competent I am. Other times I am still frightened of the world and my part in it. I'm still insecure. I'm still socially anxious, self-deprecating, and uncertain of myself a lot of the time. I have worked on and healed a lot of wounds and changed old patterns for the better, but I still fall into the old pit of depression sometimes.
Aside from the stress of school and relationships, however, I am arguably the most content and least depressed that I have ever been, or at least for as long as I can remember. I am doing my work in the world, and sometimes failing at it. I am at least moving toward my work in real and tangible ways, and getting better at what I do.
I am not as enlightened or close to my ideal self as I would like to be, but I'm at least working on it. That is something. I'm grateful for the chance to be getting this really ridiculous self-designed degree in a subject that doesn't even seem realistic or plausible to the majority of the world. I realize the privilege in that and am astounded by it. I think I'm calling it Sacred Erotic Psychology now, though even that isn't quite right. It's gone though a bunch of different iterations.
Relationships are consistently a struggle right around the end of the quarter. It's like all the stress likes to get saved up until right at the end. So that's fun. Onyx and I have had some rough patches in the last few months specifically, though we always go through alternating rough and smooth times, as is the nature of long-term relationships it seems. We had a period of really great connecting after a major shake-up in our relationship due to a rather major breaking of our agreements just before the end of last quarter. We both have come to a lot of insights of our own patterns in relationships and the patterns in our relationship with each other that we need and want to break. It has been really useful and there have been lots of growing pains. The period of connecting was really lovely and some of the best moments of our relationship in recent memory, but that too was broken and we're now in a slightly awkward phase again. Yet not as awkward as a lot of the last year has been, so I don't know. Only now there is a limited amount of time and energy available to really get back to smooth due to thesis writing.
So. Thesis. Yes. I need to be writing about the theoretical orientations that are foundational to my thesis, as well as historical background related to the body that informs my thesis, and the beginnings of articulating my own theoretical synthesis as well as my praxis approach. It's a lot.
My current thesis statement/elevator speech is this: I am articulating how I as a practitioner can present eroticism as an embodied experience of love that promotes and nurtures intra-, inter-, and trans-personal connections. By integrating our embodied and mythological experience of our minds, hearts, and body/genitals though the process of identifying the disconnected parts needing to be integrated and using a variety of psychological and bodywork techniques to foster mutually beneficial relationships between ourselves and these parts we move toward experiencing and expressing our Whole Erotic Self through embodied sovereignty. This is important because loving connection and embodied erotic experiences can advance our own developmental learning, enhance our quality of life, and benefit the earth.
Not bad, right?
For those of you who don't know, I have been attending Antioch University since the Fall of 2011 working on a self-designed Masters program in Psychology. Last Wednesday, the 12th, I had my Application Project Plan Approval Degree Committee Meeting (yes, apparently the name is that long). I met with the three other people who will be assessing, evaluating, and helping me through the process of my Applied Thesis in my last three quarters at Antioch.
My plan for my thesis was approved, which means that today I am submitting the syllabus for the next three quarters of my Application Project! This is a big deal.
This means I am nearly at the end of my time at Antioch and will, at the end of the year, have a Masters in Integrative Studies in Psychology, focusing on Sacred Erotic Somatic Psychology. I plan to graduate at the end of Fall Quarter 2014.
The proposed timeline is: I will begin working on my Applied Thesis next quarter, starting in April, and I will finish in December, giving me nine months to work through the nine credits of my Application Project. I have been referring to this as my Grad School Pregnancy ("I'm pregnant with grad school," I've been saying) and I plan to birth my Thesis Baby in December.
This also means that my time from now until December, with the exception of the breaks between quarters, will be extremely limited. I don't yet know if this will be more limited than it has been in previous quarters, but I imagine that may likely be true.
I do at some point want to get back into writing on here on a regular basis and reviewing on my other site. I have aspirations, but I will likely not have time for that until December.


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A comprehensive report on the composition and monitoring of infant formula milks in the UK is now available to download from the Caroline Walker Trust website. The report is of interest to health professionals supporting mothers and babies and to professional bodies and Government departments with an interest in infant health. The report highlights the lack of objective information available and the weakness of systems to monitor and regulate infant formula.
Click here to visit the Caroline Walker Trust website.
Unicef UK statement on working with breast pump companies26 January 2015
UNICEF UK Baby Friendly Initiative has received a number of queries regarding the provision of infant formula to parents of babies when accessing food banks. After consultation with relevant experts and organisations the following statement has been prepared. Organisations are welcome to use this statement (written April 2014) as the basis for their own policies and guidelines. 28 April 2014
Donations to UNICEF UK do not fund the Baby Friendly Initiative, the expenses of the Baby Friendly Initiative are covered by the costs of training and assessment. No element of profit for UNICEF or the baby friendly initiative is included in these costs. © 2010 UNICEF UK.

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COLUMBUS, Ohio – Dr. Richard Goldberg, (43235) an internationally renowned gastrointestinal oncologist at The Ohio State University Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute (OSUCCC – James), presented the first Charles G. Moertel Lecture of the Alliance for Clinical Trials in Oncology during the plenary session of the group's meeting in Chicago on June 30.
This is the first annual Moertel lecture being given through the newly merged cooperative group known as the Alliance for Clinical Trials in Cancer, which is a nationwide clinical research community sponsored by the National Cancer Institute.
The Moertel Lecture was initiated in 1995 by the cooperative group Cancer and Leukemia Group B (CALGB) to honor the legacy of Moertel, one of the founding fathers of the North Central Cancer Treatment Group, which is a national clinical research group sponsored by the NCI. Moertel, a renowned cancer researcher and former director of the Mayo Comprehensive Cancer Center, died in 1994.
"We believe that Rich Goldberg – like no one else – embodies the spirit of Dr. Moertel as an integrative force in oncology research, in particular, GI medical oncology," said Dr. Monica M. Bertagnolli, chief of surgical oncology at Dana-Farber/Brigham and Women's Cancer Center and group chair of the Alliance for Clinical Trials in Oncology. "We are pleased that he has accepted the invitation to serve as the first Charles G. Moertel Lecturer of the Alliance."
During his presentation titled, "Meaningful Outcomes: Lives Saved Due To Clinical Trials in Early Stage Colon Cancer," Goldberg discussed his personal relationship with Moertel, whose footsteps he followed in at the Mayo Clinic.
Goldberg, who is the physician-in-chief at OSUCCC – James, also explained Moertel's work in making the first major discovery on how to increase the surgical cure rate of stage III colon cancer by adding postoperative chemotherapy, and how that initial discovery has led to further improved outcomes over 35 years of additional research.
A member and former chair of the NCI's Colorectal Task Force, Goldberg is an international leader in evaluating new agents for the treatment of colorectal cancer and researching inherited colorectal cancer syndromes.
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute strives to create a cancer-free world by integrating scientific research with excellence in education and patient-centered care, a strategy that leads to better methods of prevention, detection and treatment. Ohio State is one of only 41 National Cancer Institute (NCI)-designated Comprehensive Cancer Centers and one of only seven centers funded by the NCI to conduct both phase I and phase II clinical trials. The NCI recently rated Ohio State's cancer program as "exceptional," the highest rating given by NCI survey teams. As the cancer program's 210-bed adult patient-care component, The James is a "Top Hospital" as named by the Leapfrog Group and one of the top 20 cancer hospitals in the nation as ranked by U.S. News & World Report.
# # #
Contact: Eileen Scahill, Wexner Medical Center Public Affairs and Media Relations, 614-293-3737, or email@example.com


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Slice by Darkcloud013Watch
©2012-2016 Darkcloud013
Slice up the speed
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Hoo Boy! A Hamlet Full Of Hobos
The streets of America today are lined with — politically incorrectly speaking — hobos, tramps and bums who are out of work, out of luck, out of money, out of hope.
But what exactly is the difference between a hobo, a tramp and a bum?
For one thing: Hobos hold an annual gathering in Britt, Iowa.
This year's National Hobo Convention will be held this week. There will be hobo poetry, a hobo parade, the coronation of a Hobo King and Queen, and more.
We asked Linda Hughes of the Hobo Foundation if anyone has ever suggested that the word "hobo" might be inappropriate or pejorative?
"No one has ever challenged our hobo convention," Linda Hughes says. "We are proud to have the National Hobo Convention in Britt, Iowa, as a hobo is one who travels and works. A tramp just travels, and a bum does neither. Don't get the three confused."
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In recent years, the work of the International Monetary Fund has become a never-ending drama, directed by Washington, which is also known as «the main shareholder of the joint-stock company» known as the IMF. All the other shareholders, as well as the fund's staffers, are assigned the role of actors in a play written by Uncle Sam...
Valentin KATASONOV | 30.12.2015
According to World Bank expert Eric Schwaitzern, a wave of city bankruptcies is expected to hit the United States in the next three years possibly triggering sovereign default. Today over 450 US cities are on the verge of going broke, including Los Angeles, San Diego and others. The «ghost city» Detroit started «the parade of defaults» that may be expedited in October to last all year long... Washington appears to get ready for emergency. Richard Preston, leader of the Confederate White Knights of KKK, called on Americans to get together in a civil war against Barack Obama and his supporters and do it in October, when the country marks the 150th anniversary of Gettysburg...
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The Annual Meetings of the International Monetary Fund (IMF) and the World Bank Group was held in Tokyo on October 12-13. The conventions tend to be fairly technical in character, but, due to at least a couple of reasons, the latest one was an exception from the rule. First, the speakers in Tokyo seemed to have shed their usual pretense of optimism... Secondly, serious concerns simply had to arise in connection with a certain cryptic passage in a contribution to the debate made by IMF Managing Director Christine Lagarde. «Without growth, the future of the global economy is in jeopardy, and perhaps the greatest roadblock will be the huge legacy of public debt, which now averages 110% in advanced economies, pretty much wartime levels», said Lagarde. One is tempted to read the above as a warning that the epoch of peace is about to end and the world currently finds itself on the brink of a major war...
Valentin KATASONOV | 15.10.2012
In a statement commemorating the fifth anniversary of the New START Treaty between the US and Russia last week, US Secretary of State John Kerry not only expressed hope that both sides would be able to implement the treaty within the specified time frame – by 5 February 2018 – but also renewed calls for Moscow to begin talks on the further reduction of their countries' nuclear arsenals...
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Republishing is welcomed with reference to Strategic Culture Foundation on-line journal www.strategic-culture.org.


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Fri, 18 November 2011 at 6:20 pm
Andrew Garfield: 'Spider-Man' in NYC!
Andrew Garfield gives a grin while waiting around on the set of The Amazing Spider-Man on Friday (November 18) in New York City.
The 28-year-old actor bundled up in a jacket for his chilly day of filming in the Big Apple!
PHOTOS: Check out the latest pics of Andrew Garfield
Earlier in the week, Andrew and his rumored gal pal and Spider-Man co-star Emma Stone were spotted taking a stroll and eating on the go together.
The Amazing Spider-Man is set to be released on July 3, 2012!
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Credit: Richie Buxo; Photos: SplashNewsOnline Posted to: Andrew Garfield


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Best cinnamon rolls (2000)
A popular breakfast, lunch and dinner spot, Racines has long been known for its baked goods, especially the brownies. But lately we've become addicted to its big, fluffy cinnamon rolls, a quintessential version of the old favorite: light, soft, swirled with cinnamon, and with just the right number of raisins to ensure that you get a plump, sweet one every few mouthfuls. And then there's the icing on the cake, a super-sweet slick that turns into a sugary crust around the edges and pushes an ooze of butter over the top. Grab a cup of coffee and one of these babies, and you're starting the day on a roll.
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Stream or download Friday's edition of MMAjunkie Radio with guests Martin Kampmann, Dave Meltzer, Jeremy Botter and Richard Hunter.Filed under: News, Radio read news >>
A lightweight contest pitting Dave "The Caveman" Rickels against Bobby Cooper has been added to the main card of Bellator 150: Galvao vs. Dantas 2. read news >>
Stream or download Monday's edition of MMAjunkie Radio with guests Miesha Tate, Duane Finley and 'Vegas Dave' Oancea.Filed under: News, Radio, UFC read news >>
MMAjunkie Radio kicks off at 1 p.m. ET (10 a.m. PT) with guests Miesha Tate, Duane Finley and "Vegas" Dave Oancea in studio.Filed under: News, UFC read news >>
UPDATE: Pro gambler Dave Oancea may have tried to pull a fast one on the internet. But our Jeremy Botter spoke in person with a representative of the William Hill bookmaker, which reportedly issued t read news >>
"Vegas" Dave Oancea is a professional gambler who owns a consulting site for bettors. If that name sounds familiar, it is because he won $2.5 million on the Kansas City Royals winning the World Serie read news >>
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Episode No. 29 of "The MMA Road Show with John Morgan" podcast, featuring Ali Abdelaziz, Dave Branch and Dustin Poirier, is now available for streaming and download.Filed under: News, UFC, WSOF read news >>
The mashup of Dave Chappelle and the Nick Diaz hearing is comical and similar at the same time. read news >>
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Left Seat West
6801 N Glen Harbor Blvd, Suite 104
Glendale, AZ 85307
(Google Maps)
The Left Seat West is a local business with a comfortable environment that provides the charm of watching the airplanes land and depart from Glendale Municipal Airport. The restaurant has a great view and is the perfect place for watching the planes arrive and depart. Diners can enjoy a good home cooked meal in the light and airy atmosphere of the restaurant and delight in all the aviation décor, or enjoy our outside patio. The owners, Ron and Karen Zamenski, take great pride in providing good home cooked food at reasonable prices with emphasis on providing friendly and exceptional service. Whether you are visiting for breakfast, lunch, or a business meeting or banquet, you'll be well taken care of at the Left Seat West!
Data is submitted by registered FlightAware members on 2012-Apr-09 15:53.
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Top Definition
A term of endearment, as well as mockery often used in conjunction with the word prick.
Alright spindle are you coming out tonight? Or are you gonna stay in and be a spindle prick? HONK!
by Leeug October 23, 2003
Skinny legs or somthing along those lines
haha look at them spindles
by Jay deezy February 14, 2005
n. a person that plays the drums. Joe Fitzgerald.
Yo, spindle, get me a beat!
by Victor April 11, 2003


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Best Underground Restaurant (2011)
The Salt Cellar
With little more than a door and a few blue awnings visible, this long-running restaurant looks less like the upscale seafood joint it claims to be and more like the kind of fast-food joint where disinterested, college-aged servers wearing eye patches would dish up greasy fish and chips. That's because most of The Salt Cellar is hidden underground in a cavernous dining room with no windows and only a skylight for natural light. The effect is a little eerie, but the chef's dedication to importing fresh seasonal catches such as Georges Bank sea scallops, New Zealand Bluenose sea bass and mussels from Maine makes us willing to overlook any claustrophobic discomfort.
More Awards from This Winner
Location Details
Scottsdale AZ 85257
More Food & Drink Awards
Best Underground Supper ClubWoody's Underground
Best Tunnel in a Tourist TrapRustler's Rooste
Best Underground Food TraditionA Mormon pantry
Best Shaved-Ice CartDouble D Lite


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Definitions for pćstum
This page provides all possible meanings and translations of the word pćstum
We couldn't find a direct definition for the term pćstum.
Maybe you were looking for one of these terms?
pædophiliacs, pław, płomyk, płonko, p–n junction, q, q & a, q beta replicase, q care international, q factor


text:
Autodesk® Subscription offers the most convenient, modern, and flexible way to purchase and access the software and services that you need to help grow your business. Subscription customers enjoy access to the latest software releases, technical support, and flexible licensing. In addition, a variety of Autodesk® 360 cloud benefits help them increase mobility; streamline collaboration; and visualize, optimize, and share more design options.
With more purchasing options than ever before, you can choose the plan that best fits your current project needs and budget. Autodesk Subscription puts software, services, and support at your command to accelerate your complete workflow, now and into the future.
It's never been easier to buy Autodesk software with options tailored to your business. Discover the subscription options that help you more easily access the specific Autodesk tools and services you need.
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Maximize the value of your perpetual license with the latest upgrades, flexible licensing, technical support, and access to select cloud and software services.
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Extend your workflow to the cloud for virtually infinite computing power, collaboration tools, and access to your files and software—anytime, anywhere.
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text:
Biological Safety
UF Sharps Injuries Decline in 2014
All needle-sticks/sharps injuries and splashes of potentially infectious material to mucous membranes are reported to the Workers' Compensation Office and subsequently tracked by the Biosafety Office (Figure 1). These types of incidents constitute a major risk for exposure to Bloodborne Pathogens (BBPs). In 2014 there were 124 needle-stick/sharps injuries at UF, the lowest incidence in the last 9 years and significantly down from the 164 reported the previous year. In contrast, the number of splash exposures increased from 22 exposures in 2013 to 30 in 2014.
Despite the encouraging reduction in sharps injuries in 2014, BBP exposures continue to be an issue, especially in the clinical setting. As shown in Figure 2, the majority of sharps injuries occurred during surgery or surgery-related invasive procedures (46%). Placement of in-line catheters, blood draws, and injections, combined, led to 24% of the sharps injuries. An additional 10% of injuries were inflicted by a fellow worker. Interestingly, the source of 9% of the reported sharps injuries was unknown to the victim. All exposures and incidents should continue to be reported so that trends or problems associated with particular procedures, specialties, or equipment can be identified and addressed.
To minimize occupational hazards from needle-sticks and splashes, BBP training must be completed annually. Please stay safe, continue to report and reduce exposures, and remember to:
- Follow universal precautions when handling all human source material
- Employ safe handling practices with sharps, e.g. not recapping needles, disposing of sharps directly into a sharps container, not overfilling the sharps container, etc.
- Use sharps with passively-activated safety devices whenever possible
- Wear appropriate personal protective equipment (PPE), including eye protection, masks, and gloves
- Seek immediate medical treatment for BBP exposures; antiviral therapy is most effective when administered right away


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Saturday, February 6, 2016
In this production from Benedict Bogeaus and RKO Radio, Robert Ryan stars as a fugitive from justice who hides out in the Far Eastern teak plantation managed by Barbara Stanwyck. As the two fall in love, Stanwyck comes to believe in Ryan's innocence. Upon the arrival of doggedly determined security officer David Farrar, Ryan and Stanwyck escape into the treacherous Burmese jungles. Like many of Bogeaus's productions of the 1950s, Escape to Burma was directed by Allan Dwan. ~ Hal Erickson, Rovi


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Your luxury home away from home 1AustraliaVictoriaWilliamstown
About this listing
You can Instant Book with a Special Offer of 20% of entire stay, send me your dates before at: margaret12@(URL HIDDEN) (when sending email remove the space between gmx. and info)
Even if the calendar is labeled as "not available" CONTACT ME!
Central heating or a heater in the listing
The Space
The Home
Modern 3 bedroom home with individual rooms with ensuites. This listing is for a double room, that can be converted to a triple for an extra charge of $100.
The Rooms
Each room has TV, DVD, heating, airconditioning. We offer either a continental or fully cooked a la carte breakfast. Close to shops, restaurants, parks, beaches, Werribee Zoo, Sciencworks. Wireless internet available with plenty of parking. Guest lounge. Tea and Coffee. Home cooked produce.
The Area
Williamstown is A village close to the City of Melbourne. Accessible by car, train, bus and ferry. Lots of restaurants, street cafes, pubs and coffee shops. Magnificent views of the city skyline and the ports of Melbourne.
Fishing port, naval shipyards, yachting, motorboat cruising and other water activities
Restaurants, Cafes, Deli's, Hotels. From a la carte dining to take away fish and chips. From Mexican to Italian, to Japanese, Chinese, Malaysian - all cuisines catered for.
Take a ferry ride to South bank or Port Melbourne, a 30 minute train ride to the City.
Enjoy the local outdoor craft market on the 3rd Sunday of every month


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A speeder is pulling directly away and increasing his distance froma police car that is moving at 25 m/s with respect to the ground.The radar gun in the police car emits an electromagnetic wave witha frequency of
7.00 109
Hz. The wave reflects from the speeder's carand returns to the
police car, where its frequency is measured tobe 326 Hz less than
the emitted frequency. Find the speeder's speedwith respect to the


text:
Please log in or register to manage your account
Model: 10849 Item: CDB10849
Delightful candy-coated gum in two flavors. Two pieces of spearmint or peppermint flavored gum per pack; assorted packs per box. Food Type: Gum; Flavor: Peppermint/Spearmint; Packing Type: Box.
Printerbazaar is a one-stop destination for all your office supplies. From highly durable branded printers to a plethora of accessories, you can get your suitable product at a competitive cost.
At Printerbazaar, we are committed to make your shopping experience hassle-free by conveying the best information. We understand that office related purchasing decisions are vital and thus the right comparisons are necessary before buying.
Chiclets® Chewing Gum, Peppermint or Spearmint, 2-Pieces/Pack, 200/Box
$15.11$952 / each
Swedish Fish® Grab-and-Go Candy Snacks In Reception Box, 240-Pieces/Box
$18.54$1242 / each
Certs® Mints, Wintergreen 12-Pieces/Pack, 24 Packs/Box
$18.35$1266 / each


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cross networking?!?!
for the xbox360 and pc will there be an cross networking?? like if its an MMO it would be nice to know there would be more players...it might make the game more popular.
Age Of Conan are going to go about that! iam sure this will also ;)
Although AoC might go about it differently, you can either play on an Xbox360 world only or else choose to play with Xbox 360 and Pc versions.
For the PC user it will be alot easier to navigate around the map and use hotkeys which gives the PC owner at an advantage. So I wont be to surprized if they dont allow Xbox Users play against PC users....it would be good if they gave you the option and let the gamer choose what he/she wants.
if you read ign on the xbox360 spring update microsoft is curently making a keyboard for the 360 check my profile pic if you wanna see how it looks like
twice I heard you mention your pic of the keyboard! surely once is enough?
But yea!! it would be great.
As long as DoF is not going to be a crossport version of the X360 game...or this will be a living nightmare!
Well imagine this...look at the amount of buttons you have on a keyboard compared to the gamepad!! id hate to play this on a gamepad!!
Its really aqward using a gamepad in RTS games!!! terrible if ya ask me:p
The limited controls of the Xbox have always been a problem with RTS games and games that allow PC vs Xbox players already proved that the PC players have a very big advantage so as long Microsoft doesnt make the Xbox more RTS friendly I think there shouldn't be PC vs Xbox matches in DoF.
I suppose it could be possible to make DoF compatible with keyboard and mouse on the 360 though as there are 2 usb ports however i am not positive.
We are planning on including cross-networking for DoF. However as the technology is quite new, we might run across too many problems and have to scrap that feature.
Xbox users will have slight advantages in places PCs don't.
For example, the Xbox User Interface is quite different from the PC, due to the limited amount of buttons you have to work with, as well as a less-precise control stick vs. a mouse. So we have developed a unique control scheme and a user interface that is unique to the Xbox version and will help players manage their armies much easier.
Xbox users also get benefits from having a version that is optimized to run on their system, which means no matter how many units you have on your screen, or what spells or actions are being cast, it wont lag or stall. This is just undoable on a PC, as everyone's PC is different and we cannot optimize it for them, changing settings on their own can make a game run smoother, but certain events can trigger signifigant drops in performance.
Also, Xbox users on average have a faster internet connection speed as well, as they are not bogged down by firewalls and other security measures that windows takes.
That made me feel sad :( My computer has slow internet and the computer itself is slow. Hopefully I'll get a new one before DoF is released.
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10 September 2012
Intertek acquires NDT Services Limited
Intertek Group plc (Intertek), the leading international provider of quality services to a wide range of industries, announces that it has acquired Materials Testing & Inspection Services Limited and its operating subsidiary NDT Services Limited (NDT), a provider of non-destructive testing services to the energy, petrochemical, power and aerospace industries.
The company was purchased from its management shareholders for a cash consideration of GBP 17 million.
NDT's non-destructive testing is used by companies to assess the integrity and reliability of a range of industrial components being manufactured or on installations. NDT helps clients to identify flaws or defects in aircraft, pipeline, power station, refinery and oil platform components to assess their projected lifespan in order to reduce the risk of failure and disruption to operations.
Demand for NDT's services is driven by increasing regulation and standardisation of components, new and ageing infrastructure and industrial products, and by increased investment in quality assurance by companies to reduce operational and reputational risks. NDT holds key industry accreditations and is a leading European provider of non-destructive testing to the ae``rospace industry and is a prominent operator in the power sector.
NDT has 130 full-time employees and is located in the UK, with headquarters in Derby and sites near Bristol and Birmingham. The company will form part of Intertek's Industry & Assurance division.
Wolfhart Hauser, Chief Executive, Intertek Group plc, commented:
"NDT has a strong reputation and market position and we are pleased to welcome the company to Intertek. Building on our Moody acquisition, this acquisition enhances our existing services to our energy, petrochemical, power and aerospace clients and reflects our strategy of continually expanding our capabilities to meet the full quality needs of clients in each industry".
Aston Swift / Sarah Ogilvie Intertek
Telephone: +44 (0) 20 7396 3400
email@example.com / email@example.com
Richard Mountain, FTI
Telephone: +44 (0) 20 7269 7291
Corporate website: www.intertek.com
About Intertek
Intertek is a leading provider of quality and safety solutions serving a wide range of industries around the world. From auditing to inspection, to testing, quality assurance and certification, Intertek people are dedicated to adding value to customers' products and processes, supporting their success in the global marketplace. Intertek has the expertise, resources and global reach to support its customers through its network of more than 33,000 people in over 1,000 laboratories and offices in more than 100 countries. Intertek Group plc (LSE: ITRK) is listed on the London Stock Exchange and is a constituent of the FTSE 100 index.
This information is provided by RNS
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Bradford W Ozanne
Beatson Institute for Cancer Research, Glasgow, Scotland, United Kingdom
Are you Bradford W Ozanne?
Claim your profile
Total impact
Available from: Andrew Campbell
P-Rex1 Cooperates with PDGFR beta to Drive Cellular Migration in 3D Microenvironments
Andrew D Campbell
Samuel Lawn
Lynn C McGarry
Heidi C Welch
· Bradford W Ozanne ·
Jim C Norman
[Show abstract]
[Hide abstract]
Expression of the Rac-guanine nucleotide exchange factor (RacGEF), P-Rex1 is a key determinant of progression to metastasis in a number of human cancers. In accordance with this proposed role in cancer cell invasion and metastasis, we find that ectopic expression of P-Rex1 in an immortalised human fibroblast cell line is sufficient to drive multiple migratory and invasive phenotypes. The invasive phenotype is greatly enhanced by the presence of a gradient of serum or platelet-derived growth factor, and is dependent upon the expression of functional PDGF receptor β. Consistently, the invasiveness of WM852 melanoma cells, which endogenously express P-Rex1 and PDGFRβ, is opposed by siRNA of either of these proteins. Furthermore, the current model of P-Rex1 activation is advanced through demonstration of P-Rex1 and PDGFRβ as components of the same macromolecular complex. These data suggest that P-Rex1 has an influence on physiological migratory processes, such as invasion of cancer cells, both through effects upon classical Rac1-driven motility and a novel association with RTK signalling complexes.
Full-text · Article · Jan 2013 · PLoS ONE
Analysis of the CD23-αv integrin interaction: A study with model peptides
Adrienne L Edkins
Gillian Borland
Sharon M Kelly
Richard J Cogdell
· Bradford W Ozanne ·
William Cushley
[Show abstract]
[Hide abstract]
The human CD23 protein binds to αvβ3 and αvβ5 integrins. The integrins recognize a short tripeptide motif of arg-lys-cys (RKC) in CD23, and peptides containing this motif inhibit the binding of CD23 to B cells and monocytes; neither fibronectin, nor vitronectin, which contain arg-gly-asp motifs, inhibit binding of RKC-containing peptides to cells. RKC-containing peptides derived from CD23 show dose-dependent, biphasic binding profiles to both αvβ3 and αvβ5 that are cation-independent but sensitive to high chloride ion concentrations. Substitution of one basic residue in the RKC motif with alanine reduces but does not abolish integrin binding or the ability of peptides to stimulate pre-B cell growth or cytokine release by monocytes. Substitution of both basic residues abolishes both integrin binding and biological activity of CD23-derived peptides. These features indicate that binding of RKC-containing peptides to αv integrins has clearly distinct characteristics to those for binding of RGD-containing ligands.
No preview · Article · Apr 2012 · Biochemical and Biophysical Research Communications
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Available from: Adrienne L Edkins
Differential regulation of monocyte cytokine release by αV and β2 integrins that bind CD23
Adrienne L Edkins
Gillian Borland
Mridu Acharya
Richard J Cogdell
· Bradford W Ozanne ·
William Cushley
[Show abstract]
[Hide abstract]
The human soluble CD23 (sCD23) protein displays highly pleiotropic cytokine-like activity. Monocytic cells express the sCD23-binding integrins αVβ(3), αVβ(5), αMβ(2) and αXβ(2), but it is unclear which of these four integrins most acutely regulates sCD23-driven cytokine release. The hypothesis that ligation of different sCD23-binding integrins promoted release of distinct subsets of cytokines was tested. Lipopolysaccharide (LPS) and sCD23 promoted release of distinct groups of cytokines from the THP-1 model cell line. The sCD23-driven cytokine release signature was characterized by elevated amounts of RANTES (CCL5) and a striking increase in interleukin-8 (IL-8; CXCL8) secretion, but little release of macrophage inflammatory protein 1β (MIP-1β; CCL4). Antibodies to αVβ(3) or αXβ(2) both promoted IL-8 release, consistent with the sCD23-driven pattern, but both also evoked strong MIP-1β secretion; simultaneous ligation of these two integrins further increased cytokine secretion but did not alter the pattern of cytokine output. In both model cell lines and primary tissue, integrin-mediated cytokine release was more pronounced in immature monocyte cells than in mature cells. The capacity of anti-integrin monoclonal antibodies to elicit a cytokine release response is epitope-dependent and also reflects the differentiation state of the cell. Although a pattern of cytokine release identical to that provoked by sCD23 could not be elicited with any individual anti-integrin monoclonal antibody, αXβ(2) and αVβ(3) appear to regulate IL-8 release, a hallmark feature of sCD23-driven cytokine secretion, more acutely than αMβ(2) or αVβ(5).
Full-text · Article · Feb 2012 · Immunology
Available from: Adrienne L Edkins
CD23/FcepsilonRII: molecular multi-tasking
M Acharya
G Borland
AL Edkins
L M Maclellan
J Matheson
· B W Ozanne ·
W Cushley
[Show abstract]
[Hide abstract]
CD23 is the low-affinity receptor for immunoglobulin (Ig)E and plays important roles in the regulation of IgE responses. CD23 can be cleaved from cell surfaces to yield a range of soluble CD23 (sCD23) proteins that have pleiotropic cytokine-like activities. The regions of CD23 responsible for interaction with many of its known ligands, including IgE, CD21, major histocompatibility complex (MHC) class II and integrins, have been identified and help to explain the structure-function relationships within the CD23 protein. Translational studies of CD23 underline its credibility as a target for therapeutic intervention strategies and illustrate its involvement in mediating therapeutic effects of antibodies directed at other targets.
Full-text · Article · Oct 2010 · Clinical & Experimental Immunology
Available from: Eric Kenneth
Spectral Clustering of Microarray Data Elucidates the Roles of Microenvironment Remodeling and Immune Responses in Survival of Head and Neck Squamous Cell Carcinoma
Johanna K Thurlow
Claudia L. Pena Murillo
Keith D Hunter
Francesca M Buffa
Shalini Patiar
Guy Betts
Catharine M L West
Adrian L Harris
Eric K Parkinson
Paul R Harrison
· Bradford W Ozanne ·
Max Partridge
Gabriela Kalna
[Show abstract]
[Hide abstract]
To identify functionally related prognostic gene sets for head and neck squamous cell carcinoma (HNSCC) by unsupervised statistical analysis of microarray data. Microarray analysis was performed on 14 normal oral epithelium and 71 HNSCCs from patients with outcome data. Spectral clustering (SC) analysis of the data set identified multiple vectors representing distinct aspects of gene expression heterogeneity between samples. Gene ontology (GO) analysis of vector gene lists identified gene sets significantly enriched within defined biologic pathways. The prognostic significance of these was established by Cox survival analysis. The most influential SC vectors were V2 and V3. V2 separated normal from tumor samples. GO analysis of V2 gene lists identified pathways with heterogeneous expression between HNSCCs, notably focal adhesion (FA)/extracellular matrix remodeling and cytokine-cytokine receptor (CR) interactions. Similar analysis of V3 gene lists identified further heterogeneity in CR pathways. V2CR genes represent an innate immune response, whereas high expression of V3CR genes represented an adaptive immune response that was not dependent on human papillomavirus status. Survival analysis demonstrated that the FA gene set was prognostic of poor outcome, whereas classification for adaptive immune response by the CR gene set was prognostic of good outcome. A combined FA&CR model dramatically exceeded the performance of current clinical classifiers (P < .001 in our cohort and, importantly, P = .007 in an independent cohort of 60 HNSCCs). The application of SC and GO algorithms to HNSCC microarray data identified gene sets highly significant for predicting patient outcome. Further large-scale studies will establish the usefulness of these gene sets in the clinical management of HNSCC.
Full-text · Article · Jun 2010 · Journal of Clinical Oncology
Available from: Alan Riboldi-Tunnicliffe
Novel -Propeller of the BTB-Kelch Protein Krp1 Provides a Binding Site for Lasp-1 That Is Necessary for Pseudopodial Extension
Christopher H Gray
Lynn C McGarry
Heather J Spence
Alan Riboldi-Tunnicliffe
· Bradford W Ozanne
[Show abstract]
[Hide abstract]
Kelch-related protein 1 (Krp1) is up-regulated in oncogene-transformed fibroblasts. The Kelch repeats interact directly with the actin-binding protein Lasp-1 in membrane ruffles at the tips of pseudopodia, where both proteins are necessary for pseudopodial elongation. Herein, we investigate the molecular basis for this interaction. Probing an array of overlapping decapeptides of Rattus norvegicus (Rat) Krp1 with recombinant Lasp-1 revealed two binding sites; one ((317)YDPMENECYLT(327)) precedes the first of five Kelch repeats, and the other ((563)TEVNDIWKYEDD(574)) is in the last of the five Kelch repeats. Mutational analysis established that both binding sites are necessary for Krp1-Lasp-1 interaction in vitro and function in vivo. The crystal structure of the C-terminal domain of rat Krp1 (amino acids 289-606) reveals that both binding sites are brought into close proximity by the formation of a novel six-bladed beta-propeller, where the first blade is not formed by a Kelch repeat.
Full-text · Article · Sep 2009 · Journal of Biological Chemistry
Available from: Mridu Acharya
SDF-1 and PDGF enhance αvβ5-mediated ERK activation and adhesion-independent growth of human pre-B cell lines
M Acharya
A L Edkins
· B W Ozanne ·
W Cushley
[Show abstract]
[Hide abstract]
CD23 acts through the alphavbeta5 integrin to promote growth of human pre-B cell lines in an adhesion-independent manner. alphavbeta5 is expressed on normal B-cell precursors in the bone marrow. Soluble CD23 (sCD23), short CD23-derived peptides containing the arg-lys-cys (RKC) motif recognized by alphavbeta5 and anti-alphavbeta5 monoclonal antibodies (MAbs) all sustain growth of pre-B cell lines. The chemokine stromal cell-derived factor-1 (SDF-1) regulates key processes during B-cell development. SDF-1 enhanced the growth-sustaining effect driven by ligation of alphavbeta5 with anti-alphavbeta5 MAb 15F-11, sCD23 or CD23-derived RKC-containing peptides. This effect was restricted to B-cell precursors and was specific to SDF-1. The enhancement in growth was associated with the activation of extracellular signal-regulated kinase (ERK) and both these responses were attenuated by the MEK inhibitor U0126. Finally, platelet-derived growth factor also enhanced both alphavbeta5-mediated cell growth and ERK activation. The data suggest that adhesion-independent growth-promoting signals delivered to B-cell precursors through the alphavbeta5 integrin can be modulated by cross-talk with receptors linked to both G-protein and tyrosine kinase-coupled signalling pathways.
Full-text · Article · Aug 2009 · Leukemia: official journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Available from: Lindsay C Spender
TGF-β-mediated activation of RhoA signalling is required for efficient V12HaRas and V600EBRAF transformation
Y M Fleming
G J Ferguson
L C Spender
J Larsson
S Karlsson
· B W Ozanne ·
R Grosse
G J Inman
[Show abstract]
[Hide abstract]
Transforming growth factor beta-1 (TGF-beta) acts as both a tumour suppressor and a tumour promoter in a context-dependent manner. The tumour-promoting activities of TGF-beta are likely to result from a combination of Smad and non-Smad signalling pathways but remain poorly understood. Here we show that TGF-beta-mediated activation of RhoA is dependent on the kinase activity of ALK5 and that continuous ALK5 activity maintains basal RhoA-ROCK signalling, cell morphology and actin dynamics in serum-starved rodent fibroblasts independently of Smad2, Smad3 and Smad4. In immortalized human diploid fibroblasts, we show that oncogenic rewiring by transduction of (V12)HaRas instigates regulation of RhoA-ROCK signalling through an autocrine TGF-beta1-ALK5 pathway. Furthermore, we show that ALK5-mediated activation of RhoA is required for efficient (V12)HaRas, V-Raf and (V600E)BRAF transformation and (V12)HaRas-mediated anchorage-independent growth. These findings identify a new pro-oncogenic activity of TGF-beta and indicate that tumours harbouring (V12)HaRas and (V600E)BRAF mutations may be susceptible to TGF-beta signalling inhibitors.
Full-text · Article · Feb 2009 · Oncogene
Available from: Kwai Wa Cheng
Rab25 Associates with α5β1 Integrin to Promote Invasive Migration in 3D Microenvironments
Patrick T Caswell
Heather J Spence
Maddy Parsons
Dominic P White
Katherine Clark
Kwai Wa Cheng
Gordon B Mills
Martin J Humphries
Anthea J Messent
Kurt I Anderson
Mary W McCaffrey
· Bradford W Ozanne ·
Jim C Norman
[Show abstract]
[Hide abstract]
Here, we report a direct interaction between the beta1 integrin cytoplasmic tail and Rab25, a GTPase that has been linked to tumor aggressiveness and metastasis. Rab25 promotes a mode of migration on 3D matrices that is characterized by the extension of long pseudopodia, and the association of the GTPase with alpha5beta1 promotes localization of vesicles that deliver integrin to the plasma membrane at pseudopodial tips as well as the retention of a pool of cycling alpha5beta1 at the cell front. Furthermore, Rab25-driven tumor-cell invasion into a 3D extracellular matrix environment is strongly dependent on ligation of fibronectin by alpha5beta1 integrin and the capacity of Rab25 to interact with beta1 integrin. These data indicate that Rab25 contributes to tumor progression by directing the localization of integrin-recycling vesicles and thereby enhancing the ability of tumor cells to invade the extracellular matrix.
Full-text · Article · Nov 2007 · Developmental Cell
Available from: jbc.org
vbeta5 Integrin Sustains Growth of Human Pre-B Cells through an RGD-independent Interaction with a Basic Domain of the CD23 Protein
Gillian Borland
Adrienne L Edkins
Mridu Acharya
Johanne Matheson
Lindsey J White
Janet M Allen
Jean-Yves Bonnefoy
· Bradford W Ozanne ·
William Cushley
[Show abstract]
[Hide abstract]
CD23 is a type II transmembrane glycoprotein synthesized by hematopoietic cells that has biological activity in both membrane-bound and freely soluble forms, acting via a number of receptors, including integrins. We demonstrate here that soluble CD23 (sCD23) sustains growth of human B cell precursors via an RGD-independent interaction with the alphavbeta5 integrin. The integrin recognizes a tripeptide motif in a small disulfide-bonded loop at the N terminus of the lectin head region of CD23, centered around Arg(172), Lys(173), and Cys(174) (RKC). This RKC motif is present in all forms of sCD23 with cytokine-like activity, and cytokine activity is independent of the lectin head, an "inverse RGD" motif, and the CD21 and IgE binding sites. RKC-containing peptides derived from this region of CD23 bind alphavbeta5 and are biologically active. The binding and activity of these peptides is unaffected by inclusion of a short peptide containing the classic RGD sequence recognized by integrins, and, in far-Western analyses, RKC-containing peptides bind to the beta subunit of the alphavbeta5 integrin. The interaction between alphavbeta5 and sCD23 indicates that integrins deliver to cells important signals initiated by soluble ligands without the requirement for interactions with RGD motifs in their common ligands. This mode of integrin signaling may not be restricted to alphavbeta5.
Preview · Article · Oct 2007 · Journal of Biological Chemistry
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Available from: Valerie Brunton
p120-catenin is required for the collective invasion of squamous cell carcinoma cells via a phosphorylation-independent mechanism
I R Macpherson
S Hooper
A Serrels
L McGarry
· B W Ozanne ·
K Harrington
M C Frame
E Sahai
V G Brunton
[Show abstract]
[Hide abstract]
Loss of E-cadherin-mediated cell-cell junctions has been correlated with cancer cell invasion and poor patient survival. p120-catenin has emerged as a key player in promoting E-cadherin stability and adherens junction integrity and has been proposed as a potential invasion suppressor by preventing release of cells from the constraints imposed by cadherin-mediated cell-cell adhesion. However, it has been proposed that tyrosine phosphorylation of p120 may contribute to cadherin-dependent junction disassembly during invasion. Here, we use small interfering RNA (siRNA) in A431 cells to show that knockdown of p120 promotes two-dimensional migration of cells. In contrast, p120 knockdown impairs epidermal growth factor-induced A431 invasion into three-dimensional matrix gels or in organotypic culture, whereas re-expression of siRNA-resistant p120, or a p120 isoform that cannot be phosphorylated on tyrosine, restores the collective mode of invasion employed by A431 cells in vitro. Thus, p120 promotes A431 cell invasion in a phosphorylation-independent manner. We show that the collective invasion of A431 cells depends on the presence of cadherin-mediated (P- and E-cadherin) cell-cell contacts, which are lost in cells where p120 expression is knocked down. Furthermore, membranous p120 is maintained in invasive squamous cell carcinomas in tumours suggesting that p120 may be important for the collective invasion of tumours cells in vivo.
Full-text · Article · Sep 2007 · Oncogene
Available from: Robert F Hennigan
Transcription factors control invasion: AP-1 the first among equals
B W Ozanne ·
H J Spence
L C McGarry
R F Hennigan
[Show abstract]
[Hide abstract]
Metastasis, the aggressive spread of a malignant tumor to distant organs, is a major cause of death in cancer patients. Despite this critical role in cancer outcomes, the molecular mechanisms that control this process are just beginning to be understood. Metastasis is largely dependent upon the ability of tumor cells to invade the barrier formed by the basement membrane and to migrate through neighboring tissues. This review will summarize the evidence that tumor cell invasion is the result of oncogene-mediated signal transduction pathways that control the expression of a specific set of genes that together mediate tumor cell invasion. We focus on the role of the transcription factor AP-1 to both induce the expression of genes that function as invasion effectors and repress other genes that function as invasion suppressors. This identifies AP-1 as a critical regulator of a complex program of gene expression that defines the invasive phenotype.
Full-text · Article · Feb 2007 · Oncogene
Low expression of HER2 protein in breast cancer is biologically significant
S M Tovey
J R Reeves
P Stanton
· B W Ozanne ·
J M S Bartlett
T G Cooke
[Show abstract]
[Hide abstract]
HER2 status is routinely tested using immunohistochemistry or FISH following the licensing of a therapeutic agent targeting HER2. However, neither of these methods provides quantitative information relating to the 70-80% of patients with levels of expression lower than the assay detection thresholds. In this study, radioimmunohistochemistry was used to detect quantitative HER2 protein expression in 178 breast cancers. Survival analysis was performed, as were correlations with known prognostic variables and with overexpression of other HER family members. It is demonstrated that the populations expressing very high and very low levels of HER2 are each associated with increased risk of cancer-specific death on survival analysis (p = 0.0043). The group with low levels of HER2 was more likely to be of higher grade, EGFR-positive and ER/HER3/HER4-negative. HER2-positive cases were frequently ER-negative/HER3-positive, whilst cases with normal HER2 expression were often ER-positive/HER4-positive. The aggressive nature of the tumour group with low HER2 expression may be explained by actions of other HER family members, particularly EGFR, but whether these or other factors have a negative regulatory effect on HER2 expression remains to be determined.
No preview · Article · Nov 2006 · The Journal of Pathology
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Available from: Steven Michael Walker
Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: A link to integrin function
N O Carragher
S M Walker
L. A. Scott Carragher
F Harris
T K Sawyer
V G Brunton
· B W Ozanne ·
M C Frame
[Show abstract]
[Hide abstract]
Cancer cells can invade three-dimensional matrices by distinct mechanisms, recently defined by their dependence on extracellular proteases, including matrix metalloproteinases. Upon treatment with protease inhibitors, some tumour cells undergo a 'mesenchymal to amoeboid' transition that allows invasion in the absence of pericellular proteolysis and matrix degradation. We show here that in HT1080 cells, this transition is associated with weakened integrin-dependent adhesion, consistently reduced cell surface expression of the alpha2beta1 integrin collagen receptor and impaired signalling downstream, as judged by reduced autophosphorylation of focal adhesion kinase (FAK). On examining cancer cells that use defined invasion strategies, we show that distinct from mesenchymal invasion, amoeboid invasion is independent of intracellular calpain 2 proteolytic activity that is usually needed for turnover of integrin-linked adhesions during two-dimensional planar migration. Moreover, an inhibitor of Rho/ROCK signalling, which specifically impairs amoeboid-like invasion, restores cell surface expression of alpha2beta1 integrin, downstream FAK autophosphorylation and calpain 2 sensitivity--features of mesenchymal invasion. These findings link weakened integrin function to a lack of requirement for calpain 2-mediated integrin adhesion turnover during amoeboid invasion. In keeping with the need for integrin adhesion turnover, mesenchymal invasion is uniquely sensitive to Src inhibitors. Thus, the need for a major pathway that controls integrin adhesion turnover defines and distinguishes cancer cell invasion strategies.
Full-text · Article · Oct 2006 · Oncogene
Invasion is a genetic program regulated by transcription factors
Bradford W Ozanne ·
Heather J Spence
Lynn C McGarry
Robert F Hennigan
[Show abstract]
[Hide abstract]
The invasive and metastatic behaviour of tumours impacts crucially on the clinical management of cancer. Accordingly, it is important to understand the regulation of tumour cell invasiveness. Genetic analysis of worms, Drosophila and mice has provided evidence that invasion is a genetic pathway regulated by transcription factors that are often implicated in tumour cell invasion. Recent evidence has revealed much concerning the role of one particular transcription factor, AP1, which is involved in the regulation of a multigenic invasion program in which upregulated and downregulated genes function as invasion effectors and suppressors, respectively. Differentially expressed genes cooperatively enhance pseudopod elongation during the mesenchymal mode of invasion by altering the function, localisation and activity of non-differentially expressed proteins.
No preview · Article · Mar 2006 · Current Opinion in Genetics & Development
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Available from: Michael F Olson
AP-1 Differentially Expressed Proteins Krp1 and Fibronectin Cooperatively Enhance Rho-ROCK-Independent Mesenchymal Invasion by Altering the Function, Localization, and Activity of Nondifferentially Expressed Proteins
Heather J Spence
Lynn McGarry
Catherine S Chew
Neil O Carragher
Linda A Scott-Carragher
Zhengqiang Yuan
Daniel R Croft
Michael F Olson
Margaret Frame
· Bradford W Ozanne
[Show abstract]
[Hide abstract]
The transcription factor AP-1, which is composed of Fos and Jun family proteins, plays an essential role in tumor cell invasion by altering gene expression. We report here that Krp1, the AP-1 up-regulated protein that has a role in pseudopodial elongation in v-Fos-transformed rat fibroblast cells, forms a novel interaction with the nondifferentially expressed actin binding protein Lasp-1. Krp1 and Lasp-1 colocalize with actin at the tips of pseudopodia, and this localization is maintained by continued AP-1 mediated down-regulation of fibronectin that in turn suppresses integrin and Rho-ROCK signaling and allows pseudopodial protrusion and mesenchyme-like invasion. Mutation analysis of Lasp-1 demonstrates that its SH3 domain is necessary for pseudopodial extension and invasion. The results support the concept of an AP-1-regulated multigenic invasion program in which proteins encoded by differentially expressed genes direct the function, localization, and activity of proteins that are not differentially expressed to enhance the invasiveness of cells.
Full-text · Article · Mar 2006 · Molecular and Cellular Biology
Role of Mayven, a Kelch-related protein in oligodendrocyte process formation
Sarah K Williams
Heather J Spence
Ryan R Rodgers
· Bradford W Ozanne ·
Una Fitzgerald
Susan C Barnett
[Show abstract]
[Hide abstract]
Oligodendrocyte function is central to the maintenance of the normal nervous system in health and disease. In particular, process formation and the generation of large sheets of myelin are important components of their biological properties. We have investigated the role of Mayven, a recently identified member of the kelch family of proteins, in process extension in oligodendrocyte-lineage cells. The kelch superfamily consists of a large number of structurally diverse proteins characterized by the presence of a kelch-repeat domain. Other members of this family associate with the actin cytoskeleton and regulate process length. Mayven is expressed predominantly in the CNS, has six kelch repeats, and is an actin-binding protein, associating with actin through its kelch-repeat domain. We have cloned rat Mayven and examined its role in the oligodendrocyte lineage by using RT-PCR, RNA interference, and a truncated, dominant-negative myc-tagged Mayven. Oligodendrocyte precursors treated with siRNA directed to Mayven have reduced process length, but there was no change in migration or expression of differentiation markers. Immunocytochemistry demonstrated that Mayven associated with F-actin at cell tips. Finally, overexpression of truncated Mayven lacking the SH3 ligand binding domain in oligodendrocyte-lineage cells resulted in shorter process formation, which was augmented when the cells were plated on laminin and fibronectin. These data suggest a role for Mayven in oligodendrocyte precursor cell process formation.
No preview · Article · Sep 2005 · Journal of Neuroscience Research
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McGarry LC, Winnie JN, Ozanne BW.. Invasion of v-Fos(FBR)-transformed cells is dependent upon histone deacetylase activity and suppression of histone deacetylase regulated genes. Oncogene 23: 5284-5292
Lynn C McGarry
Joseph N Winnie
· Bradford W Ozanne
[Show abstract]
[Hide abstract]
Transformation of fibroblasts with the v-fos oncogene produces a highly invasive phenotype that is mediated by changes in gene expression. Inhibition of histone deacetylase (HDAC) activity with trichostatin A (TSA) or valproic acid (VPA) at concentrations that do not affect morphology, motility, chemotaxis or proliferation, strongly inhibits invasion and results in the re-expression of a significant proportion of those genes that are downregulated in the v-Fos-transformed cells. Independent expression of three of these re-expressed genes, (Ring1 and YY1 binding protein (RYBP); protocadherin gamma subfamily C,3 (PCDHGC3); and signal transducer and activator of transcription 6 (STAT6)) in Fos-transformed cells, has no effect on morphology, motility, chemotaxis or proliferation, but strongly inhibits invasion. Therefore, we conclude that the ability of v-Fos-transformed cells to invade is dependent upon repression of gene expression through either direct or indirect HDAC activity.
No preview · Article · Aug 2004 · Oncogene
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Available from: Eric Kenneth
Scott LA, Vass JK, Parkinson EK, Gillespie DA, Winnie JN, Ozanne BW.. Invasion of normal human fibroblasts induced by v-Fos is independent of proliferation, immortalization, and the tumor suppressors p16INK4a and p53. Mol Cell Biol 24: 1540-1559
Linda A Scott
J Keith Vass
E Kenneth Parkinson
David A F Gillespie
Joseph N Winnie
· Bradford W Ozanne
[Show abstract]
[Hide abstract]
Invasion is generally perceived to be a late event during the progression of human cancer, but to date there are no consistent reports of alterations specifically associated with malignant conversion. We provide evidence that the v-Fos oncogene induces changes in gene expression that render noninvasive normal human diploid fibroblasts highly invasive, without inducing changes in growth factor requirements or anchorage dependence for proliferation. Furthermore, v-Fos-stimulated invasion is independent of the pRb/p16(INK4a) and p53 tumor suppressor pathways and telomerase. We have performed microarray analysis using Affymetrix GeneChips, and the gene expression profile of v-Fos transformed cells supports its role in the regulation of invasion, independent from proliferation. We also demonstrate that invasion, but not proliferation, is dependent on the activity of the up-regulated epidermal growth factor receptor. Taken together, these results indicate that AP-1-directed invasion could precede deregulated proliferation during tumorigenesis and that sustained activation of AP-1 could be the epigenetic event required for conversion of a benign tumor into a malignant one, thereby explaining why many malignant human tumors present without an obvious premalignant hyperproliferative dysplastic lesion.
Full-text · Article · Mar 2004 · Molecular and Cellular Biology
Downregulated AP-1 activity is associated with inhibition of Protein-Kinase-C-dependent CD44 and ezrin localisation and upregulation of PKC theta in A431 cells
Genevieve Stapleton
Angeliki Malliri
· Bradford W Ozanne
[Show abstract]
[Hide abstract]
Progression to an invasive, metastatic tumour requires the coordinated expression and function of a number of gene products, as well as their regulation in the context of invasion. The transcription factor AP-1 regulates expression of many of those genes necessary for implementation of the invasion programme. Two such gene products, CD44 and ezrin, are both upregulated in fibroblasts transformed by v-fos and are commonly implicated in cell motility and invasion. Here we report that CD44 and ezrin colocalise to membrane ruffles and microvilli of A431 cells after treatment with EGF. However, A431 cells expressing dominant-negative c-Jun (TAM67), and which as a consequence fail to invade in response to EGF, also fail to correctly localise CD44 and ezrin. CD44 and ezrin are both substrates for Protein Kinase C, and we show that their EGF-dependent colocalisation requires Protein Kinase C activity. Associated with TAM67 expression and disrupted CD44 and ezrin colocalisation is the increased expression and activation of the novel PKC theta isoform. Expression of PKC theta in A431 cells results in the inhibition of cell motility and disrupted localisation of CD44 and ezrin. We propose that AP-1 regulates the integrity of Protein Kinase C signalling and identifies PKC theta as a potential suppressor of the invasion programme.
No preview · Article · Aug 2002 · Journal of Cell Science
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Beatson Institute for Cancer Research
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text:
Tuesday, September 2, 2008
Attractively Valued International dividend stocks
1) Company has consistently increased dividends for more than 5 consecutive years
2) The P/E ratio is less than 20
3) The Dividend Payout Ratio does not exceed 50%
4) The dividend yield is equal to or higher than the dividend yield on the S&P 500
This screen selected 38 out of the 97 international dividend achievers in the index. You could check out the list from this link as well.
As usual this list is just a starting point. Before you leap into buying these stocks always check out at least the ten year financials trends in order to determine how your potential investment has performed over time. In addition to that try reading the annual reports but don't get caught up in recent developments which would prevent you from seeing the big picture.
Relevant Articles:
- International Dividend Achievers for diversification
- Diageo (DEO) Dividend analysis
- My Dividend Growth Plan - Diversification
- Introduction to Currency ETF's
7 comments:
I enjoyed your Diageo post. This is a stock I recently purchased. I'm currently looking at National Grid PLC. I would be interested in your analysis including dividend coverage and safety (debt). Thanks, DonReplyDelete
Thanks a lot for stopping by. I would look into National Grid (NGG) ADR's and try to anlayze it.
- TopForeignStocksSeptember 2, 2008 at 4:26 PM
Interesting list of stocks.I am watching a few of them.thanks for the post.I think utilities like NGG etc. are attractive at these levels.ReplyDelete
- AnonymousSeptember 3, 2008 at 6:21 PM
Thank you for the article can u make the chart larger to read the data more easily?ReplyDelete
why is a p/e of 16-18 for a stock valued reasonably if it is growing at lets say 7-9%? Many of these div plays have higher p/e's to their growth rate.
Thanks for stopping by. I will have to analyze NGG. The only thing that worries me there is the fact that I could find only 5 years worth of data for this stock. I'll keep digging.
If you follow the link above the table, you will find a google spreadsheet that has a bigger visibility than the embedded one on the site.
I myself has set a rule to not pay more than 20 times earnings for a stock in order to avoid losing money by chasing "hot growth" stocks.
I don't think that P/E ratios have to be equal to the growth rate of earnings.
- AnonymousSeptember 6, 2008 at 3:31 PM
TTM Earnings and therefore P/E don't look right for UL.ReplyDelete
Report I have has earnings at $1.91 not $7+.
Yahoo Finance claims that the EPS is $7.
I would love to have some screener with reliable data.
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By strategically investing in EHR, creating a financial plan around taking risk, and establishing both a physician leadership institute and a business unit for innovation, an independent Pennsylvania health system shores up its finances for whatever the future may hold. >>>
A study of a three-year multi-practice patient-centered medical home pilot finds lackluster results. "We're now concerned that medical home transformations may not really achieve the goals set out for them at the rapid pace that people have hoped," says the study author. >>>
CMS has issued a clarification on its rule governing how Medicare classifies and pays for short hospital stays, but healthcare providers are still crying foul over the new standard. >>>
The rise of high-deductible health plans means more consumers will have healthcare coverage that mainly provides protection against catastrophic injury or illness. As these plans become more common, pharmacy chains and big box retailers are taking a greater interest in expanding their healthcare provider capacities. >>>
The delay in the employer mandate "causes a timing mismatch between the benefit of fewer uninsured patients and the negative impact hospitals face related to reduced payment updates and cuts to Medicare and Medicaid DSH," says Moody's Investor Services. >>>
A study commissioned by America's Health Insurance Plans is predicting a second consecutive year of deep payment cuts for Medicare Advantage programs which "could result in a high degree of disruption in the MA market." >>>
Harold D. Miller, president and CEO of the non-profit Center for Healthcare Quality and Payment Reform, discusses a fundamental barrier to shifting payment models in healthcare: Some providers mistakenly think all they have to do is tweak existing fee-for-service billing structures without understanding what drives costs in the underlying payment system. >>>
Cleveland Clinic is increasing its ROI on the EHR infrastructure it has invested in by working toward becoming, in effect, the new data center for a growing number of other, otherwise non-affiliated, providers. >>>
The next 12 months may be the most transformative in the history of the healthcare industry. This report provides timely insights from our Intelligence Unit and top industry executives into the evolving attitudes of healthcare leaders—and the clinical, financial, and alignment moves they're making today to successfully negotiate the coming shift from volume to value.
Purchase Today >>>
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text:
Q: What Should I Do?
Teddy and Shorty are my cats Teddy is about 18 years old and she is spayed and Shorty he is 7 years old and is nuetered. Teddy has always tolorated Shorty just fine and she was here first but Shorty ever since he was a kitten he has picked on Teddy. The other day I was getting ready to leave to my grandma's house and the weird thing was Shorty didn't do anything to Teddy and she hissed at him and started smacking him for no reason they had been getting along better until that day and I seperated them before I left but when I came back Teddy had beat Shorty up so bad that he would not come out from under the dresser not even to eat and he still will only come out if Teddy is not in the room now and Shorty will still watch all over the place for Teddy and if he sees her he will run back under my dresser. This isn't like Shorty and Teddy at all and nothing has changed so what should I do and why is this happening?
Got a question about your pet? Get the answers you need from Zootoo's community of pet experts and owners.


text:
You limited your search to:
Decade: 1880-1889
Collection: From Plowshares to Diplomas: Digitizing Early Denton History
[Varied Entertainment Given By Miss Bass' School]
Date: c. 1883-11-09
Creator: unknown
Description: Announcement for varied entertainment provided by the teachers and pupils of Miss Bass' School under the direction of Madame Richard at the Opera House on November 9, 1883.
Contributing Partner: Denton Public Library
The Denton School
Date: c. 1884-03-11
Creator: unknown
Description: Announcement about the schedule, tuition, and courses of Denton School in Denton, Texas in the year 1884. The announcement also contains a list of faculty and information about the city of Denton.
Contributing Partner: Denton Public Library
Minutes of First Annual Session of the Denton County Baptist Association
Date: c. 1886-10-01
Creator: Denton County Baptist Association
Description: Minutes of the Organization and First Annual Session of the Denton County Baptist Association. The booklet contains the list of delegates, constitution, rules of order, and the declaration of faith of the association.
Contributing Partner: Denton Public Library
Spring Trade! Fain, Peery, and Shelton!!
Date: c. 1882-03-11
Creator: Fain, Perry, & Shelton
Description: An 1882 advertisement for Fain, Peery, and Shelton claims the very latest style from New York and other eastern markets. Dress goods, buntings, lawns, alpaccas, cashmeres, carpets, etc. are sold at this department store on the east side of the square.
Contributing Partner: Denton Public Library
I.O.O.F. Cemetery Deed
Date: c. 1887-06-13
Creator: Long, D.R.
Description: The deed contains C. C. Bell's purchase of the Odd Fellows' Cemetery, located in Denton, Texas, for the sum of twenty dollars on June 13th, 1887. The deed was drafted and signed in the Denton Lodge, No. 82, of the I.O.O.F.
Contributing Partner: Denton Public Library
Texas Grand State Farmers Alliance delegates certificate
Date: July 12, 1886
Creator: unknown
Description: This delegates certificate includes the minutes of a meeting held on July 12th, 1886 in which the officers and representatives were selected. The certificate lists all of the representatives chosen.
Contributing Partner: Denton Public Library
Program for fourth of July ball held in Opera House 1883
Date: July 4, 1883
Creator: unknown
Description: This program for the Fourth of July ball that was held at the Opera House in Denton includes an order of dance, lists of committee members, and other information regarding the ball. The Graham Opera House was located on the west side of the square.
Contributing Partner: Denton Public Library
[Photograph of Susie Whitlock Moten]
Date: 1886~
Creator: unknown
Description: Photograph with charcoal over the portrait of Susie A. Whitlock (Moten). She is not smiling and has a very close-cut hair style. She is wearing a dark dress.
Contributing Partner: Courthouse-on-the-Square Museum
Stanfield Lodge
Date: 1888
Creator: unknown
Description: Seven officers of the Stanfield Lodge for 1888. Pictured are: W. F. Egan, W. R. Dudley, J. W. Cook, C. H. Clements, S. M. Bradley, J. R. McCormick, W. H. Sprawls.
Contributing Partner: Denton Public Library
Judge W. J. Austin
Date: September 8, 1888
Creator: Weatherington, G. R.
Description: Group of unidentified individuals on the west side of Denton Square for the funeral procession of Judge W. J. Austin.
Contributing Partner: Denton Public Library