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A lot of the toys we play with as kids have a huge influence on what we desire as adults. If you played with 'Transformers' as a child, then it's only natural that you would want a robot that can transform itself into a car. And, if you happen to be a Robo-One robot designer, you just might go ahead and make one yourself. . .
That's just what Nakamura-san at Himeji Soft Works in Japan decided to do, and he certainly had the know-how and experience to make it happen.
The robot/car creation, named "WR-07" had us drooling, as you can easily imagine from the screen shots below. It's featured in action in the latest streaming video on the robot-fan.net website (see links below). We can hardly wait to see it do its stuff in person at the Robo-One competition event here next month.
The car smoothly and easily stands up . . .
and in a few seconds it's a Robo-One class battle robot. . .
and after the fight, it turns back into a car and drives off in victory.
Very, very cool. We want one!!!
The quote, "A car and a robot are a boy's dreams", is our rough translation of the March Hare's comment in Japanese, writing about the transforming robot. We think he's right on the money. Here's the video - what do you think?
Note: The video has been so popular that it overloaded the robot-fan.net site.
Related links:
Streaming video - via robot-fan.net (Japanese)
Robot-fan.net - Great Japanese robot fan site (Japanese)
Himeji Soft Works website - (Japanese)


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Capturing Marian's Story
Creative writing class interviews seniors for StoryCorps national oral history project.
Intelligent written and verbal communication, critical analysis, cultural consciousness, reading comprehension – these are skills that last a lifetime. Around here, they're only the beginning.
The Department of English at the University of San Francisco offers both major and minor programs with a literature or writing concentration. Central to these programs is the belief that the close study of literature offers great pleasure, intellectual challenge and versatile training for a variety of careers.
Our professors help students develop a greater understanding of the power of language and thought, the rich diversity of literary traditions and the cultural contexts of literary production. Students will mature as readers, thinkers and writers, be able to engage in analysis and discussion and write with acuity and critical self-awareness.
Sigma Tau Delta, the International English Honor Society, celebrates high achievement in language, literature, and writing. The USF chapter organizes book swaps, open mics, fundraisers for the San Francisco community, and readings by writers from all over the Bay Area. Members are eligible for a variety of Sigma Tau Delta scholarships, have an opportunity to submit papers for publication, and may apply for co-sponsored internships. Wondering how to qualify? Contact firstname.lastname@example.com to learn more.
Mon-Fri, 9 a.m. - 5:30 p.m.

subset: commoncrawl


text:
Monrovia - Liberia's National Election Commission (NEC) has announced the printing and arrival of ballot papers for the April 21, 2015 by-election in the River Cess County. The ballot papers according to the NEC were printed in the West African state of Ghana and were brought into Liberia on Monday, April 13 with a total of twenty four thousand, two hundred (24,200) currently being packaged for election day.
"Distinguished ladies and gentlemen, members of the Press, Civic and voter education activities are also proceeding quite well in the county. Town Criers, Civic educators and gender monitors recruited by the National Elections Commission are currently conducting civic and voter activities in the county", NEC disclosed. The action is being complemented by additional field staffs that include elections magisterial and field coordination personnel from several election magisterial areas across Liberia.
At a news conference Wednesday at the NEC headquarters in Monrovia, acting NEC chairman Sarah Cooper told journalists that as part of the preparations and awareness, community radio stations in the County as well as national media institutions are also providing awareness while posters and fliers for the by-election are being used to complement CVE activities in Rivercess county. Commissioner Cooper called on all registered voters in electoral District #2, Rivercess County to turn out in mass and vote for the candidate of their choice on Tuesday April 21, 2015.
Prior to Wednesday event the NEC in March this year released the names of qualified candidates and campaigning with key electoral dates of County by-election to replace Senator Francis Paye who created the vacancy as a result of his election into the senate in the December 20, 2014 special senatorial election. Qualified candidates by NEC for the process include; Bartee Charles Zarkpah, Doue Thomas, Green Jerry Flomo, Paul Gabriel, Reeves Jerome Garmonblo, Wally Matthew, Wesseh Lucky, Zah Kofi Bob and Zahnewes Byron Wehgbiah.
Cllr. Toe said up to date, there has been no report of rancor or misbehavior either on the part of the candidates or their supporters something she described as a welcoming development and implored the candidates and their supporters to continue along this path to midnight April 19 the official date for the end of political campaigning.
Said Commissioner Copper: "Members of the Press, distinguished ladies and Gentlemen, in preparation for the polling process on April 21, 2015, the National Election Commission is concluding the process of recruiting more than 200 temporary staffs to serve as poll workers while shortlisted candidate are being processed and are to be trained shortly to conduct polling activities on Election Day". She continued "In keeping with the key dates for the Rivercess County Electoral District Number two, the commission is pleased to declare the start of political campaign today Wednesday, March 25, 2015".
In the declaration of the start of the campaign, the NEC's Acting Chairman called on all candidates and their supporters to go about their campaign activities in a peaceful manner. She wants the campaign period to be used by the candidates to market their ideologies and plans for the advancement of District Number 2 in particular and Liberia in general.


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Daily DeviationGiven 2013-05-26
... by ~ananaa shows how the right composition and use of light and shadow can transform an otherwise mundane scene into something with an engaging depth.
Suggested by *Einsilbig & `toistaitoinen ( Featured by arctoa )
Congrats on the DD
Congrats on the DD
Excellent photo because of the composition, light, textures, simplicity, everything.
Wonderful Congratulations!
well done
This is fantastic!
Congratulations on the Daily Deviation!
You deserved it
You deserved it
Incredible job!
Your entire gallery is fantastic, Ana!
Congratulations on the well deserved DD!
Your entire gallery is fantastic, Ana!
Congratulations on the well deserved DD!
Thank you all for your kind words : )
Congrats on the Daily Deviation!
Love it! Perfect composition and nice atmosphere of melancholy.
Congratulations to the well deserved DD!
Wonderful work...congrats
How amazing isn't this pic!
Magnificent, great job on this!
Very much deserved!
- Congrats on the DD!
Have a nice day!
An outstanding deconstruction of form; a fine dream-state abstraction. Good use of light and shadow as compositional elements.
that shadow really establishes a good composition, and a nice rhythm
filmowy kadr


text:
|Quick links:
Latest Team Rankings
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Member Services
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November 6, 2012
Ferentz talks Purdue and execution
James Ferentz says it comes down to players making plays and executing. He goes so far as to take some of the execution blame and goes into specific details on a play where he made a mistake. The senior center also talks about the match-up this weekend against Purdue and another pair of tough defensive tackles.


text:
Ashley's 90th
by SidJacks
A gift created for the Patriarch of our family who will be celebrating his 90th birthday!A true artist, illustrator, and motivator cannot be honored in any better way than with a book of poems and photos from his family.
Baltimore, MD photographer from Lithonia, GA.
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SidJacks: A Closer Look
Published March 20, 2014
Urine Business
Published May 27, 2012
Blurb Sites


text:
Would you let your LO (yes at the age they are now) touch goats and what not at a petting zoo? The reason I ask is b/c my friend posted pics of her letting her son (8months) pet a goat at a petting zoo...it grossed me out so much and I was just wondering if I was alone in this thought or am I a germ-afobe?
OT: Petting Zoo
MW to Gary(2-17-06) ( o Y o ) ChristFollowing*CDSAHMamma **Angel babyZLS(8-16-08) Pprom@17w & Angel Baby #2(1-1-09) *NJS(9-19-10)*LGS(3-31-13)
Comments (5)
We went to last week and he went to the petting zoo area I was about to get LO off the stroller and my DH was like HES NOT TOUCHING THOSE GOATS! so he didnt get to pet them but hes right our babies r too little n animals have all kind of germs and at this age our bbies all they do is stick theyre hans in their mouths!
Juliet + Javier = Jaden Sebastian
My little miracle born with Addison's Disease
why not? if you have a wet wipe no big deal, goats aren't like full of gross things lol. so you would wipe the hands off before they stick anything in their mouth, fun for everyone
Mamma to Greyden (9/11/10) and soon a new little peanut!
I would let him do it and wash his hands afterwards. Goats aren't a big deal. Cats and dogs are germier than that because they eat meat.
I would not let him touch reptiles or birds though.
Leah (Dec 2006), David (Sep 2010), Esther (March 2013)


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Lucila G G Pacífico
Federal University of Minas Gerais, Cidade de Minas, Minas Gerais, Brazil
Are you Lucila G G Pacífico?
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Total impact
Available from: Ricardo Toshio Fujiwara
Evaluation of the use of C-terminal part of the Schistosoma mansoni 200kDa tegumental protein in schistosomiasis diagnosis and vaccine formulation
Gardênia Braz Figueiredo de Carvalho
· Lucila Gonçalves Grossi Pacífico ·
Deborah Laranjeira Ferreira Pimenta
Liliane Maria Vidal Siqueira
Andréa Teixeira-Carvalho
Paulo Marcos Zech Coelho
Carina da Silva Pinheiro
Ricardo Toshio Fujiwara
Sergio Costa Oliveira
Cristina Toscano Fonseca
[Show abstract]
[Hide abstract]
Schistosoma mansoni tegument is involved in essential functions for parasite survival and represents a target for screening candidates for vaccine and diagnosis. Our group using reverse vaccinology selected six candidates, previously demonstrated by proteomics studies to be expressed in the parasite tegument, among them was Sm200. In this work we have cloned and expressed a recombinant form of Sm200 C-terminal (1069-1520) region. The efficacy of rSm200 (1069-1520) in the diagnosis of schistosomiasis and in the formulation of a vaccine against S. mansoni was assessed respectively in an ELISA based diagnostic assay and immunization protocols in mice. Significant differences between non-infected and acutely infected or chronically infected animals were observed and no cross-recognition was observed with sera from Ascaris suum or Ancylostoma ceylanicum infected mice. rSm200-ELISA test could also discriminate infected individuals from healthy donors not living in endemic area for schistosomiasis but failed to discriminate between individuals from a low endemic area for schistosomiasis known to have positive or negative stools after examination. Recombinant Sm200 also failed to induce protection against schistosomiasis, demonstrating that the C-terminal part of Sm200 is unable to induce protective immune response in mice. Therefore rSm200 (1069-1520)-ELISA represents an important tool to be used in the diagnosis of schistosomiasis.
Full-text · Article · Apr 2014 · Experimental Parasitology
Available from: Paola Smaldini
Unlipidated Outer Membrane Protein Omp16 (U-Omp16) from Brucella spp. as Nasal Adjuvant Induces a Th1 Immune Response and Modulates the Th2 Allergic Response to Cow's Milk Proteins
Andrés E Ibañez
Paola Smaldini
Lorena M Coria
María V Delpino
· Lucila G G Pacífico ·
Sergio C Oliveira
Gabriela S Risso
Karina A Pasquevich
Carlos Alberto Fossati
Guillermo H Giambartolomei
Guillermo H Docena
Juliana Cassataro
[Show abstract]
[Hide abstract]
The discovery of novel mucosal adjuvants will help to develop new formulations to control infectious and allergic diseases. In this work we demonstrate that U-Omp16 from Brucella spp. delivered by the nasal route (i.n.) induced an inflammatory immune response in bronchoalveolar lavage (BAL) and lung tissues. Nasal co-administration of U-Omp16 with the model antigen (Ag) ovalbumin (OVA) increased the amount of Ag in lung tissues and induced OVA-specific systemic IgG and T helper (Th) 1 immune responses. The usefulness of U-Omp16 was also assessed in a mouse model of food allergy. U-Omp16 i.n. administration during sensitization ameliorated the hypersensitivity responses of sensitized mice upon oral exposure to Cow's Milk Protein (CMP), decreased clinical signs, reduced anti-CMP IgE serum antibodies and modulated the Th2 response in favor of Th1 immunity. Thus, U-Omp16 could be used as a broad Th1 mucosal adjuvant for different Ag formulations.
Full-text · Article · Jul 2013 · PLoS ONE
Available from: Fábio Marinho
An intranasal administration of Lactococcus lactis strains expressing recombinant interleukin-10 modulates acute allergic airway inflammation in a murine model
F A V Marinho
· L G G Pacífico ·
A Miyoshi
V Azevedo
Y Le Loir
V D Guimarães
P Langella
G D Cassali
C T Fonseca
S C Oliveira
[Show abstract]
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Around 300 million people world-wide suffer from asthma, and the prevalence of allergic diseases has increased. Much effort has been used in the study of mechanisms involved in the immune response observed in asthma to intervene for the treatment of this condition. During inflammation in asthma, Th2 cytokines and eosinophils are essential components of the host immune system. Furthermore, for therapeutic interventions against this disease, IL-10 is an important cytokine because it has a central role in the regulation of inflammatory cascades. To evaluate the immunomodulatory effect of Lactococcus lactis strains expressing recombinant IL-10 in a mouse model of ovalbumin (OVA)-induced acute airway inflammation. L. lactis expressing recombinant IL-10 in a cytoplasmic (LL-CYT) or secreted form (LL-SEC) and wild-type (LL-WT) were used. IL-10 production by the recombinant strains was evaluated by ELISA. After an intranasal administration of L. lactis producing recombinant IL-10 and the induction of acute allergic airway inflammation in mice, blood samples were collected to detect IgE anti-OVA, and bronchoalveolar lavage (BAL) was harvested for eosinophil count. Additionally, the lungs were collected for the detection of the eosinophil peroxidase (EPO) activity, measurement of cytokines and chemokines and evaluation of pathology. Mice that received LL-CYT and LL-SEC strains showed a significant decrease in eosinophils numbers, EPO activity, anti-OVA IgE and IgG1 levels, IL-4 and CCL3 production and pulmonary inflammation and mucus hypersecretion, compared with the asthmatic group. Only the LL-CYT/OVA group showed reduced levels of IL-5, CCL2, CCL5 and CCL11. Treatment with L. lactis producing recombinant IL-10 used in this study (LL-CYT and LL-SEC) modulated experimental airway inflammation in the mouse model independently of Treg cells. Additionally, the LL-CYT strain was more efficient in the suppression of lung inflammation.
Full-text · Article · Oct 2010 · Clinical & Experimental Allergy
Available from: Fábio Marinho
Schistosoma mansoni antigens modulate the allergic response in a murine model of ovalbumin-induced airway inflammation
L S Cardoso
S C Oliveira
A M Góes
R R Oliveira
· L G Pacífico ·
F V Marinho
C T Fonseca
F C Cardoso
E M Carvalho
M I Araujo
[Show abstract]
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Schistosoma mansoni infection has been associated with protection against allergies. The mechanisms underlying this association may involve regulatory cells and cytokines. We evaluated the immune response induced by the S. mansoni antigens Sm22.6, PIII and Sm29 in a murine model of ovalbumin (OVA)-induced airway inflammation. BALB/c mice were sensitized with subcutaneously injected OVA-alum and challenged with aerolized OVA. Mice were given three doses of the different S. mansoni antigens. Lung histopathology, cellularity of bronchoalveolar lavage (BAL) and eosinophil peroxidase activity in lung were evaluated. Immunoglobulin (Ig)E levels in serum and cytokines in BAL were also measured. Additionally, we evaluated the frequency of CD4+forkhead box P3 (FoxP3)+ T cells in cultures stimulated with OVA and the expression of interleukin (IL)-10 by these cells. The number of total cells and eosinophils in BAL and the levels of OVA-specific IgE were reduced in the immunized mice. Also, the levels of IL-4 and IL-5 in the BAL of mice immunized with PIII and Sm22.6 were decreased, while the levels of IL-10 were higher in mice immunized with Sm22.6 compared to the non-immunized mice. The frequency of CD4+FoxP3+ T cells was higher in the groups of mice who received Sm22.6, Sm29 and PIII, being the expression of IL-10 by these cells only higher in mice immunized with Sm22.6. We concluded that the S. mansoni antigens used in this study are able to down-modulate allergic inflammatory mediators in a murine model of airway inflammation and that the CD4+FoxP3+ T cells, even in the absence of IL-10 expression, might play an important role in this process.
Full-text · Article · May 2010 · Clinical & Experimental Immunology
Available from: Fábio Marinho
Schistosoma mansoni Antigens Modulate Experimental Allergic Asthma in a Murine Model: a Major Role for CD4+ CD25+ Foxp3+ T Cells Independent of Interleukin-10
Lucila G G Pacífico ·
Fábio A V Marinho
Cristina T Fonseca
Michele M Barsante
Vanessa Pinho
Policarpo A Sales-Junior
Luciana S Cardoso
Maria Ilma Araújo
Edgar M Carvalho
Geovanni D Cassali
Mauro M Teixeira
Sergio C Oliveira
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In areas where schistosomiasis is endemic, a negative correlation is observed between atopy and helminth infection, associated with a low prevalence of asthma. We investigated whether Schistosoma mansoni infection or injection of parasite eggs can modulate airway allergic inflammation in mice, examining the mechanisms of such regulation. We infected BALB/c mice with 30 S. mansoni cercariae or intraperitoneally injected 2,500 schistosome eggs, and experimental asthma was induced by ovalbumin (OVA). The number of eosinophils in bronchoalveolar lavage fluid was higher in the asthmatic group than in asthmatic mice infected with S. mansoni or treated with parasite eggs. Reduced Th2 cytokine production, characterized by lower levels of interleukin-4 (IL-4), IL-5, and immunoglobulin E, was observed in both S. mansoni-treated groups compared to the asthmatic group. There was a reduction in the number of inflammatory cells in lungs of S. mansoni-infected and egg-treated mice, demonstrating that both S. mansoni infection and the egg treatment modulated the lung inflammatory response to OVA. Only allergic animals that were treated with parasite eggs had increased numbers of CD4+ CD25+ Foxp3+ T cells and increased levels of IL-10 and decreased production of CCL2, CCL3, and CCL5 in the lungs compared to the asthmatic group. Neutralization of IL-10 receptor or depletion of CD25+ T cells in vivo confirmed the critical role of CD4+ CD25+ Foxp3+ regulatory T cells in experimental asthma modulation independent of IL-10.
Full-text · Article · Oct 2008 · Infection and immunity
Available from: Fábio Marinho
Peptides containing T cell epitopes, derived from Sm14, but not from paramyosin, induce a Th1 type of immune response, reduction in liver pathology and partial protection against Schistosoma mansoni infection in mice
Teresa C.M. Garcia
Cristina T Fonseca
· Lucila G.G. Pacifico ·
Fernanda do Valle Durães
Fábio Antônio Vitarelli Marinho
Marcos L.O. Penido
Marcelo V Caliari
Alan L de Melo
Hudson Alves Pinto
Michele Mendes Barsante
Edecio Cunha-Neto
Sergio C Oliveira
[Show abstract]
[Hide abstract]
Sm14 and paramyosin are two major Schistosoma mansoni vaccine candidate antigens. Recently, we have identified Sm14 and paramyosin epitopes that are recognized by T cells of resistant individuals living in endemic areas for schistosomiasis. Herein, mice were immunized with these peptides separately or in association in order to evaluate their vaccine potential. Immunization of mice with Sm14 peptides alone or mixed with paramyosin peptides was able to induce 26%-36.7% or 28%-29.2% of worm burden reduction, 67% or 46% of intestinal eggs reduction and also 54%-61% or 43%-52% of liver pathology reduction, respectively. Protection was associated with a Th1 type of immune response induced by Sm14 peptide immunization. In contrast, paramyosin peptide vaccination did not engender protective immunity or liver pathology reduction and immunization was associated with a Th2 type of immune response.
Full-text · Article · Jul 2008 · Acta Tropica
Effects of sample re-sequencing and trimming on the quality and size of assembled consensus sequences
F Prosdocimi
D A O Lopes
F C Peixoto
M M Mourão
· L G G Pacífico ·
R A Ribeiro
J M Ortega
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The production of nucleic acid sequences by automatic DNA sequencer machines is always associated with some base-calling errors. In order to produce a high-quality DNA sequence from a molecule of interest, researchers normally sequence the same sample many times. Considering base-calling errors as rare events, re-sequencing the same molecule and assembling the reads produced are frequently thought to be a good way to generate reliable sequences. However, a relevant question on this issue is: how many times the sample needs to be re-sequenced to minimize costs and achieve a high-fidelity sequence? We examined how both the number of re-sequenced reads and PHRED trimming parameters affect the accuracy and size of final consensus sequences. Hundreds of single-pool reaction pUC18 reads were generated and assembled into consensus sequences with CAP3 software. Using local alignment against the published pUC18 cloning vector sequence, the position and number of errors in the consensus were identified and stored in MySQL databases. Stringent PHRED trimming parameters proved to be efficient for the reduction of errors; however, this procedure also decreased consensus size. Moreover, re-sequencing did not have a clear effect on the removal of consensus errors, although it was able to slightly increase consensus.
No preview · Article · Feb 2007 · Genetics and molecular research: GMR
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Available from: Alfredo M Góes
Polymyxin B as inhibitor of LPS contamination of Schistosoma mansoni recombinant proteins in human cytokine analysis
Luciana S Cardoso
Maria Ilma Araujo
Alfredo M Góes
· Lucila G Pacífico ·
Ricardo R Oliveira
Sergio C Oliveira
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Recombinant proteins expressed in Escherichia coli vectors are generally contaminated with endotoxin. In this study, we evaluated the ability of Polymyxin B to neutralize the effect of LPS present as contaminant on Schistosoma mansoni recombinant proteins produced in E. coli in inducing TNF-alpha and IL-10. Peripheral blood mononuclear cells from individuals chronically infected with S. mansoni were stimulated in vitro with recombinant Sm22.6, Sm14 and P24 antigens (10 microg/mL) in the presence of Polymyxin B (10 microg/mL). The levels of cytokines were measured using ELISA. There was greater than 90% reduction (p < 0.05) in the levels of TNF-alpha and IL-10 when Polymyxin B was added to the cultures stimulated with LPS. In cultures stimulated with S. mansoni recombinant proteins in the presence of Polymyxin B, a reduction in the levels of TNF-alpha and IL-10 was also observed. However, the percentage of reduction was lower when compared to the cultures stimulated with LPS, probably because these proteins are able to induce the production of these cytokines by themselves. This study showed that Polymyxin B was able to neutralize the effect of endotoxin, as contaminant in S. mansoni recombinant antigens produced in E. coli, in inducing TNF-alpha and IL-10 production.
Full-text · Article · Feb 2007 · Microbial Cell Factories
Available from: scielo.br
Aluminum hydroxide associated to Schistosoma mansoni 22.6 kDa protein abrogates partial protection against experimental infection but not alter interleukin-10 production
Lucila G G Pacífico ·
Cristina T Fonseca
Michele M Barsante
Luciana S Cardoso
Maria Ilma Araújo
Sérgio C Oliveira
[Show abstract]
[Hide abstract]
The need to develop a vaccine against schistosomiasis led several researches and our group to investigate proteins from Schistosoma mansoni as vaccine candidates. Sm22.6 is a protein from S. mansoni that shows high identity with Sj22.6 and Sh22.6 (79 and 91%, respectively). These proteins are associated with high levels of IgE and protection to reinfection. Previously, we have shown that Sm22.6 induced a partial protection of 34.5% when used together with Freund's adjuvant and produced a Th0 type of immune response with interferon-g and interleukin-4. In this work, mice were immunized with Sm22.6 alone or with aluminum hydroxide adjuvant and high levels of IgG, IgG1, and IgG2a were measured. Unfortunately, no protection was detected. Since IL-10 is a modulating cytokine in schistosomiasis, we also observed a high level of this molecule in splenocytes of vaccinated mice. In conclusion, we did not observe the adjuvant effect of aluminum hydroxide associated with rSm22.6 in protective immunity.
Preview · Article · Oct 2006 · Memórias do Instituto Oswaldo Cruz
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Available from: Alfredo M Góes
Schistosoma mansoni antigen-driven interleukin-10 production in infected asthmatic individuals
Luciana S Cardoso
Sergio C Oliveira
· Lucila G G Pacífico ·
Alfredo M Góes
Ricardo R Oliveira
Cristina T Fonseca
Edgar M de Carvalho
Maria Ilma Araújo
[Show abstract]
[Hide abstract]
Asthmatics infected with Schistosoma mansoni have a less severe course of asthma and an inhibition of the Th2 inflammatory response that seems to be mediated by interleukin (IL-10). The objective of this study was to evaluate the capacity of some S. mansoni antigens to stimulate IL-10 production in vitro by cells of asthmatic infected individuals. Peripheral bloods mononuclear cells were stimulated with the S. mansoni recombinant antigens Sm22.6, Sm14, P24, and PIII antigen. IL-10 was measured in the supernatants of cultures. As the recombinant antigens were cloned in Escherichia coli, we blocked contaminant endotoxin with polymyxin B added to the cultures. We demonstrated that all antigens used drove high production of IL-10 in S. mansoni infected individuals (n = 13, 408 +/- 514 and 401 +/- 383 pg/ml, 484 +/- 245 pg/ml, 579 +/- 468 pg/ml, respectively). In asthmatics infected with S. mansoni (n = 21) rP24 induced higher levels of IL-10 (565 +/- 377 pg/ml) when compared to PIII, rSm14 and rSm22.6 (184 +/- 209 pg/ml; 292 +/- 243 pg/ml; 156 +/- 247 pg/ml, respectively). Conclusion: the S. mansoni antigens evaluated in this study stimulated IL-10 production by cells from infected individuals and therefore they have the potential to be used as a modulator of the inflammatory response in asthma.
Full-text · Article · Oct 2006 · Memórias do Instituto Oswaldo Cruz
Co-administration of plasmid expressing IL-12 with 14-kDa Schistosoma mansoni fatty acid-binding protein cDNA alters immune response profiles and fails to enhance protection induced by Sm14 DNA vaccine alone
Cristina T Fonseca
· Lucila G G Pacífico ·
Michele M Barsante
Tatiana Rassi
Geovanni D Cassali
Sérgio C Oliveira
[Show abstract]
[Hide abstract]
Schistosomiasis is an endemic disease that affects 200 million people worldwide. DNA-based vaccine is a promising strategy to induce protective immunity against schistosomiasis, since both humoral and cellular immune responses are involved in parasite elimination. In this study, we evaluated the ability of Sm14 cDNA alone or in association with a plasmid expressing murine interleukin (IL)-12 to induce protection against challenge infection. Mice were immunized with four doses of the DNA vaccine and the levels of protection were determined by worm burden recovery after challenge infection. Specific antibody production to rSm14 was determined by ELISA, and cytokine production was measured in splenocyte culture supernatants stimulated with rSm14 and in bronchoalveolar lavage of vaccinated mice after challenge infection. DNA immunization with pCI/Sm14 alone induced 40.5% of worm reduction. However, the use of pCI/IL-12 as adjuvant to pCI/Sm14 immunization failed to enhance protection against challenge infection. Protection induced by pCI/Sm14 immunization correlates with specific IgG antibody production against Sm14, Th1 type of immune response with high levels of interferon (IFN)-gamma and low levels of IL-4 in splenocyte culture supernatants and in bronchoalveolar lavage after challenge infection. IL-12 co-administration with pCI/Sm14 induced a significant production of nitric oxide in splenocyte culture supernatants and also lymphocyte suppression, with reduced percentage of T cells producing IFN-gamma and tumor necrosis factor-alpha.
No preview · Article · Sep 2006 · Microbes and Infection
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Available from: Cristiane Torres
Fibroblast growth factor 9: Cloning and immunolocalisation during tooth development in Didelphis albiventris
Cristiane B.B. Torres
Vinicius S Goes
Alfredo M Goes
· Lucila G.G. Pacífico ·
Gerluza A.B. Silva
Nelson Lopes Junior
José B Alves
[Show abstract]
[Hide abstract]
There are no reports in literature about functional roles of fibroblast growth factor 9 (FGF-9) in tooth development in animals with complete tooth pattern. The classical model for studying tooth development is the mouse, which has small number of teeth and distinctive incisor and molar patterns. The opossum Didelphis albiventris with five upper and four lower incisors, one canine, three premolars, and four molars, on each side of the jaw, seems to be a convenient model to test results obtained in the mouse. Molecular expression studies indicate that FGF-9 participates in murine tooth initiation and regulation of morphogenesis. Searching for similarities and differences in FGF-9 expression between the opossum and the mouse, amino acid sequence and expression pattern of FGF-9 in the developing first molars of D. albiventris were characterised. FGF-9 cDNA sequence was obtained using RT-PCR and expressed in bacterial system for recombinant protein production and analysis of immunoreactivity. FGF-9 expression during tooth development was investigated by immunoperoxidase method. FGF-9 protein consists in a 209-residue polypeptide with a predicted molecular mass of 23.5 kDa. FGF-9 amino acid sequence has 98% of sequence identity to human and 97% to rodents. During tooth development, epithelial FGF-9 expression was seen at the dental lamina stage. Mesenchymal expression was seen at the bud stage and at the cap stage. No significant expression was found in the enamel knot. While in rodents FGF-9 is involved in initiation and regulation of tooth shape, it is suggested that it is only involved in tooth initiation in D. albiventris.
Full-text · Article · May 2006 · Archives of Oral Biology
Immunization with Schistosoma mansoni 22.6 kDa antigen induces partial protection against experimental infection in a recombinant protein form but not as DNA vaccine
Lucila G.G. Pacífico ·
Cristina T Fonseca
Lucimara Chiari
Sergio C Oliveira
[Show abstract]
[Hide abstract]
Schistosomiasis is a major public health problem that affects mainly developing countries. There are 200 million people worldwide infected with schistosomes resulting in more than 250,000 deaths per year. Although schistosomicidal drugs exist, the advent of an efficacious vaccine remains the most potentially powerful means for controlling this disease. In this study we isolated a cDNA clone encoding the Schistosoma mansoni lung-stage Sm22.6 protein, which is 100% and 79% identical with the 22.6 kDa adult worm tegument antigen of S. mansoni and S. japonicum, respectively. Further, we produced recombinant (r) Sm22.6 and constructed an Sm22.6 DNA vaccine. Western blot analysis confirmed the identity of purified MBP-Sm22.6 fusion protein using anti-MBP (maltose binding protein) and anti-rSm22.6 antibodies. Additionally, C57BL/6 mice were immunized and specific anti-Sm22.6 IgG responses were produced when both vaccination strategies were used. Importantly, only rSm22.6 vaccine provided levels of protection against challenge infection (34.5%). Mice immunized with rSm22.6 induced production of IgG1 and IgG2a and synthesis of IFN-gamma and IL-4 in cultured mouse splenocytes. Finally, rSm22.6 vaccination induced a Th0 type of immune response and protective immunity that suggests Sm22.6 as a potential candidate to compose an anti-schistosome vaccine.
No preview · Article · Feb 2006 · Immunobiology
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Molecular cloning and characterization of Phoneutria nigriventer toxins active on calcium channels
F.C. Cardoso
· L.G. Pacifico ·
D.C. Carvalho
J M N Victória
A L G Neves
C Chávez-Olórtegui
M.V. Gomez
E Kalapothakis
[Show abstract]
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The aim of the present study was the molecular cloning of toxins active on calcium channels expressed by the spider Phoneutria nigriventer. Clones encoding the toxins Pn3-3A, Pn3-4A, Tx3-5, Pn3-5A, Tx3-6, Pn3-6A and Pn3-6B were identified from a cDNA library derived from the venom gland of this spider, revealing toxins of 49, 76, 45, 39, 55 and 58 amino acids residues, respectively, with polypeptide precursors being composed of three major portions: a signal peptide, a propeptide and finally, the mature toxin. A high degree of homology with the amino acid sequence was found between Pn3-3A and the neurotoxin Tx3-3 (identity of 79%), and between Pn3-4A and the neurotoxin Tx3-4 (identity of 95%). The deduced amino acid sequence for the mature polypeptides Tx3-5 and Tx3-6 confirms the polypeptide sequence previously published for these neurotoxins. In addition, the toxin Pn3-5A showed 58% identity to the Tx3-5 amino acid sequence, and the toxins Pn3-6A and Pn3-6B showed 85 and 33% identity, respectively, to the Tx3-6 amino acid sequence.
Full-text · Article · Jul 2003 · Toxicon
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Cristina Toscano Fonseca
Fundação Oswaldo Cruz
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Maria Ilma Araujo
Universidade Federal da Bahia
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Federal University of Minas Gerais
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text:
Bubbalicious Brunch
Every Friday at The Westin Dubai
Bubbalicious is the exciting Friday brunch available at The Westin Dubai. With more than 10 live cooking stations in three of Dubai's hottest restaurants, Bubbalicious is the trendiest, liveliest, and among the most interactive brunches in Dubai.
Catering to young and old, families, couples and groups alike, guests will be able to move freely through each of The Westin's fabulous eateries of Blue Orange, Hunters and Spice Emporium, seeing their delicious meals prepared by the chefs as they enjoy the amazing entertainment happening all around them.


text: Team Reading List 10.25.07Oct 25 2007 By Stoney G deGeyter Read in Less than a minute0000 PPC Success in Five Steps The Importance of Images In Linkbait Articles 11 Link Usability Tips Filed Under: PPC, Search & Marketing, Usability Other Articles of Interest:Final Lap: Winning Web Marketing Reads–April 2014SEO Baby Steps: Always Be ImprovingFinal Lap: Winning Web Marketing Reads–May 2014Link Building Is Only ONE Aspect of Web MarketingFinal Lap: Winning Web Marketing Reads–June 20140000Share thisYour NameYour EmailRecipient EmailEnter a MessageI read this article and thought you might be interested in it. It is called Team Reading List 10.25.07 and is located at http://www.polepositionmarketing.com/emp/team-reading-list-102507/.CaptchaSubmit Stoney deGeyter Stoney deGeyter is the author of The Best Damn Web Marketing Checklist, Period!. He is the founder and CEO of Pole Position Marketing, a web presence optimization firm whose pit crew has been velocitizing websites since 1998. In his free time Stoney gets involved in community services and ministries with his "bride enjoy" and his children. Read Stoney's full bio. Follow Stoney:


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This is a Duracell Brand Battery for your Minolta Vectis UC. The Duracell Battery meets or exceeds original manufacturer power specifications for Minolta Vectis UC Batteries.


text:
Last time, I analyzed now update checks worked on the 3DS. That was a straightforward process. CARDBOARD (known colloquially as "System Transfer") is a bundle of complexity with no less than three separate servers communicating with each other as well as the device. A custom proprietary protocol is used for 3DS to 3DS communication. Finally, we have multiple unique identifiers the console uses to identify itself with Nintendo (serial, certificates, console id, account id, etc). I can't imagine this will be comprehensive, but I hope that whoever is reading can gain new insight on the complexity of the 3DS ecosystem. Continue reading
How to Disassemble Vita Game Cartridges
A hacker named katsu recently released a method for dumping Vita games. As a developer, I am completely against piracy, but as a reverse engineer I can't shy away from taking apart perfectly working devices. However, most pictures I see of Vita game carts taken apart show the game cart casing damaged beyond repair or completely destroyed. I managed to take apart a game cart and put it together with no obvious signs of damage, and I thought I would share my (simple) method here. Continue reading
Updates on the Vita Hardware Hacking project
After a week of trying to dump the eMMC (spoilers: didn't happen yet), I've decided to post this update about things I've tried to do (and how I tried to do it) and where the money is going to. Continue reading
Removing the CPU and NAND from PSVita
Thanks again to everyone who helped fund this project! This is the first part of the long journey into hardware land. I bought a non-working Vita logic board from eBay, which arrived yesterday, packaged like a freeze-dried snack.
In order to locate the trace from the eMMC (aka the NAND), my plan was to take a broken logic board and remove the eMMC chip and use the exposed pads and trace it to a test point or something. Then take another Vita logic board (this time with the eMMC still attached) and solder wires to the test point and dump it with an SD card reader or something (as eMMC uses the same interface as SD cards). This is a complicated plan, but it's necessary because I am not professional enough to be able to remount the eMMC (which is a tiny fine-ball-grid-array (FBGA) chip) once the trace is found. Continue reading
Unlimited Backgrounding on iOS
Since iOS4, developers have the ability to perform background tasks with some limitations. Background tasks must fit one of the five different categories for background supported apps. Music and streaming apps can be backgrounded as long as they play music. Newsstand apps can wake once a day to download updates. Location aware apps can wake up once in a while to update their position. VOIP apps can have one socket (I found out the hard way that the one socket does not include listener sockets) connected in the background. General apps can request up to 10 minutes to finish some task. While this is enough for most backgrounding purposes, sometimes we need backgrounding for more advanced tasks. Specifically, I wanted to write a HTTP proxy server that runs on the device (in the future, this proxy server will work as an ad-blocking proxy) in the background. I will show you the steps of making this work. Please note that Apple will certainly reject any app that abuses their backgrounding policy so doing so would only be useful for personal and enterprise uses. Continue reading
Unlocking T-Mobile 4G Hotspot (ZTE MF61): A case study
So, I have one of these MiFi clone from T-Mobile and want to unlock it to use on AT&T (I know that AT&T 4G/3G isn't supported, but I thought maybe I could fix that later). The first thing I tried to do was contact T-Mobile, as they are usually very liberal concerning unlock codes. However, this time, T-Mobile (or, as they claim, the manufacture) isn't so generous. So I've decided to take it upon myself to do it. I will write down the entire procedure here as a case study on how to "reverse engineer" a new device. However, in no way do I consider myself an expert, so feel free to bash me in the comments on what I did wrong. Also, I have decided against releasing any binaries or patches because phone unlocking is a grey area (although it is legal here), but if you read along you should be able to repeat what I did, even though I will also try to generalize. Continue reading
Installing Windows 8 Developer Preview (8102) on a USB Drive (Windows To Go/Portable Workspace)
This really isn't some technical or hard to do thing, but it's a cool little trick I found that I haven't seen mentioned before. If you don't know what "Windows To Go" (previously "Portable Workspace"), watch this video from the Build 2011 conference. Basically, it allows you to install a full copy of Windows 8 onto a USB drive/external hard drive and use it on any computer that supports USB booting. Your settings, files, programs, etc go where-ever you go. The feature is in Windows 8 (and the developer preview), but the program to make the drive is not. Luckily, an old leaked build has the program, but you can't just copy and paste it, it won't run. Instead, follow the directions below to get Windows 8 installed to a USB drive. (I used a virtual machine to do the following, therefore I did not need to burn any DVDs. I will give the directions assuming you're using a real computer though). Continue reading


text:
Ubuntu 9.04 Supports Ext4
Since its addition to Kernel 2.6.28, the ext4 filesystem can be manually installed in the upcoming Ubuntu release.
Ubuntu 9.04 (Jaunty Jackalope), which has its official release in April 2009, will support the ext4 filesystem that is the successor to ext3. According to Ubuntu's Colin Watson, support for the ext4 partition is already in the installer as an option. Previously it was only possible by formatting an existing non-boot partition via mkfs.ext4 on the command line.
It was not so long ago that Ted Ts'o successfully installed ext4 on his own system and kernel developers merged it into the 2.6.28 mainline code. For a while there was a hitch in adopting ext4 because of an issue with initramfs, but work to get the filesystem into a production environment is well in gear.
The filesystem offers some advantages over its ext3 predecessor. It can handle data up to 16 Terabytes and filesystems up to an Exabyte (about a million Terabytes). It also allows for an unlimited number of subdirectories and manages data types better. Regular users will also benefit from ext4 in that regular consistency tests via fsck have proved it to be markedly faster, according to Ted Ts'o.
Ubuntu kernel team member Tim Gardner reported being "really impressed" with ext4 in that file deletion proved about 20 times faster than with ext3, and kernel build times were cut in half. He also included a few links to suggestions how to migrate ext3 to the new ext4.
Issue 184/2016
Buy this issue as a PDF
Google Announces End to Flash Ad Support
Upcoming switch to HTML5-only ads is further evidence the Flash is entering its final days.
President Obama Launches New Cyber-Security Initiative
US government invests $19 billion on enhancing security and replacing ancient computer systems.
Linux Foundation Eliminates Individual Membership
But you can still be a non-voting "individual supporter" if you pay the money
Secret Backdoor Affects More Fortinet Firewalls
Several current systems could fall victim to the attack
Linus Announces Linux Kernel 4.4
Latest Linux engine comes with better graphics and support for Intel's new power-saving chips.
Mass Poem Greets Web Admins
Hackers send a message of beauty and liberation to server logs
Raspberry Pi Becomes a Thin Client
Citrix gets excited about new Pi-Powered XenDesktop client system
Microsoft Offers Linux Certification
Linux on Azure cert heralds a new era for Redmond.
CeBIT 2016: Call for Open Source Contributions
Proposals for presentations at the CeBIT Open Source Forum will be accepted through 24 January 2016.
Gone in a Flash
Adobe looks for a new start; renames its embattled Flash tool.


text:
iHerb 顾客评论
1 个顾客认为以下的评论有帮助
Reviewer3361493发表于 Aug 15, 2011
My daughter and her friends love these muffins. Can't tell they are GF. I add cinnamon to the batter and top with cinnamon sugar before I bake them. I also add blueberries sometimes. Very tasty and moist!
Great GF muffin mix
1 个顾客认为以下的评论有帮助
Reviewer1760572发表于 Jan 30, 2012
I was getting tired of paying $8 for 4 frozen gluten free muffins. This mix makes a dozen delicious muffins and you can add your own fruit or chocolate chips. They freeze well too which is an exta added bonus.
LOVE this mix!
1 个顾客认为以下的评论有帮助
4757024159710219636发表于 May 20, 2012
My family is a HUGE fan of King Arthur Flour Gluten Free Muffin Mix, Vanilla. They are incredibly easy to make and oh so delicious! Thank you, King Arthur, for developing such a yummy product!
king Arthur Flour, Gluten Free Muffin Mix, Vanilla Base, 16 oz (454 g)
1 个顾客认为以下的评论有帮助
4655167759559671435发表于 Nov 17, 2012
Very delicius and easy the preparate.
1 个顾客认为以下的评论有帮助
Reviewer1271871发表于 Dec 11, 2012
I made them with coconut oil and coconut milk, they turned out to be super soft and tender, very moist. They taste even better the next day.


text:
By the way: The cluster has one NameNode and 7 DataNodes. ...
Shawn Du
By the way: The cluster has one NameNode and 7 DataNodes.
see the output of cluster summary.
Cluster Summary
Security is OFF
69023 files and directories, 68580 blocks = 137603 total.
Heap Memory used 79.92 MB is 45% of Commited Heap Memory 176.75 MB. Max Heap Memory is 1.74 GB.
Non Heap Memory used 36.25 MB is 70% of Commited Non Heap Memory 51.50 MB. Max Non Heap Memory is 130 MB.
Configured Capacity : 1.56 TB
DFS Used : 1.21 TB
Non DFS Used : 16.22 GB
DFS Remaining : 336.78 GB
DFS Used% : 77.87%
DFS Remaining% : 21.11%
Block Pool Used : 1.21 TB
Block Pool Used% : 77.87%
you can see that most disk is taken by Block Pool.
This will causes disk is full issue when running map-reduce.
What's the root cause about this issue? how to prevent it?
The forum 'HDFS' is closed to new topics and replies.
A HDP Support Subscription connects you experts with deep experience running Apache Hadoop in production, at-scale on the most demanding workloads.
Real world training designed by the core architects of Hadoop. Scenario-based training courses are available in-classroom or online from anywhere in the world


text:
Carmen (Saura) DVD
You save £6 (37%)
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On order, dispatched within 5-10 days. Delivery timesUsually 5-7 days to reach UK addresses... Europe takes around 2 days longer and International destinations take 1-2 weeks
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Costs to other countriesUK: Free
Western Europe: £1.25
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If you are unhappy with your purchase, you can return it to us within 14 days. More details
Film Details
Directed by Carlos Saura
Produced in 1984
Main Language - Spanish with English subtitles
Countries & Regions - European Film, Spanish Film
Contemporary Drama • Contemporary Romance • European Film • Spanish Film • Musicals & Music • Stage - Dance & Ballet
MovieMail's Review
At long last Carlos Saura�s Blood Wedding (1981) and El amor brujo (1986) are reunited with their companion piece Carmen (1984). A fiesta of Flamenco fused with classical ballet and political allegory, this post-Franco trilogy is choreographed by and stars Spanish dance legend Antonio Gades.
Blood Wedding, adapted from Lorca�s 1932 play of the same name, is the most v�rit� of the trilogy, offering a fascinating insight into Gades� working methods, showing his dance troupe rehearsing Blood Wedding. The drama of Lorca�s play � about an arranged marriage that implodes amidst blood feuds and grand passion � is re-interpreted through the flamenco pyrotechnics of Gades in the role of lover, Christina Hoyos as bride and a brooding Juan Antonio Jim�nez as cuckolded groom.
More drama-documentary in feel, Carmen follows Gades� efforts to discover a Carmen for his Flamenco fusion of Prosper M�rim�e and Georges Bizet. Once he has cast the voluptuous Laura Del Sol as the quixotic gypsy and himself as her intoxicated lover, the line between his personal and professional life becomes dangerously blurred. However disorienting this is, the performers are spellbinding � whether it�s Gades dancing to the Farruca into the night or the feline Del Sol fighting for her life in the tabacalera sequence.
El amor brujo, adapted from Martinez Sierra�s 1915 one act ballet is the most streamlined of the three films: its action occurs in a gypsy shanty town impressively recreated on a vast studio stage. It�s about a cuckolded wife (Hoyos) whose philandering husband (Jim�nez) comes to a violent end. Driven mad by her loss, she attempts to dance away her demons with the help of her long-suffering suitor (Gades) and her husband�s sultry lover (Del Sol).
Saura and Gades� creative partnership has been justly compared to that of Hollywood giants, Stanley Donen and Gene Kelly: the major difference being that the Spaniards didn�t have the mighty resources of MGM at their disposal. But when Gades and Hoyos stamp and sway against a blood red sunset in El amor Brujo�s breathtaking finale, they sure do give Gene Kelly and Cyd Charisse a run for their money.
Alexander Ballinger on 28th March 2012
Author of 33 reviews
Film Description
Carlos Saura's exhilarating film of Carmen - the second film in his 'flamenco trilogy' - mixes magical choreography, rousing Flamenco dances and operatic flourishes that reference Bizet's masterwork. He explores the tale by presenting a modern ensemble of musicians and dancers led by choreographer Antonio (Antonio Gades) who casts an unknown girl (Laura del Sol) to dance the title role in his new version of Carmen. During the course of rehearsals, the plot of the production and reality become inextricably and tragically intertwined, effectively telling Carmen's story twice in one film. Guitarist Paco de Lucia contributes to the soundtrack.
DVD Details
Certificate: PG
Publisher: Studio Canal
Length: 103 mins
Aspect ratio: 1.85:1 widescreen
Format: DVD Colour
Region: 2
Released: 23rd April 2012
Cat No: OPTD1290
Film Stills
Community Reviews
People who liked Carmen (Saura)
Total of 12 people


text:
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These mini aluminium speakers can link to smart phones, mp3 players and laptops. The speakers provide 360 degree surround sound and up to 30 hours use from the rechargeable internal battery. Lightweight and protected in a Chassis leather case, make these speakers perfect for travelling.


text:
"What we want is to create a powerful sense of dread."
"See? The longer the note, the more dread."Note: this is a Music trope. If you were looking for bees, check out Bee Afraid and Bee Bee Gun. In music, a drone is a sustained, continuous sound, note or tone-cluster. Music based around drones will emphasize minimalism and texture, timbre, eventually harmony, with less concern over rhythm and melody. Because the atmosphere created by this kind of music tends to be extremely creepy and unsettling, it is a close cousin of the Psycho Strings, and the two often overlaps, but are just as often very distinct: the original psycho strings, for instance, are not drony at all, and many drones do not use strings, rather relying on low played brass instruments, or weird apparatuses and machines to produce their sounds. Drone based music can delve into Nightmare Fuel particularly efficiently if it uses what is called "infrasound," which simply put, is sound pitched so low that it's just barely above the human threshold of hearing it as an individual tone. Studies have been conducted showing that this ultra low pitched sound, while almost undetectable to people, has a strange ability to cause nervousness, and even physical discomfort, despite the listener not even being aware of hearing it. there's even some speculation that local harmonic resonance in certain areas is responsible for people perceiving those locations as being haunted. Frequently used in Horror stories (particularly Psychological Horror ones), but can show up in other genres as well (generally as a way to highligh that, whatever the appearances are, something very wrong/unusual is going on under the fragile surface of reality). Not to be confused with the similarly named part of a bagpipe (which however does produce a droning sound), an Attack Drone, or a male honey bee (even though the musical element, the instrument part and the robot are all named after the animal, which in turn is named after the onomatopoeia for the sound it makes). Note that old-fashioned bagpipes and the like do rely heavily on the more contemplative drone in place of a bass section.
open/close all folders
- The Worldwide Reveal Trailer for Modern Warfare 3 overlaid scenes of Monumental Damage with a chilling, rhythmic, atonal blast reminiscent of a siren, only a couple registers lower and slower. As the film progressed, it was combined in chorus with the tone used for the Emergency Alert System in the United States.
Anime and Manga
- Mononoke: When the Kabuki Sounds are replaced by low droning brass instruments, you know something creepy is about to happen.
- Serial Experiments Lain: The powerlines make an ominous humming sound, made creepier by the implication that Lain is the only one who hears it.
- Two Thousand One A Space Odyssey: Whenever the Monolith is involved, drony contemporary classical music composed by György Ligeti (see below) is heard.
- Irreversible has a horrible techno drone repeat over and over in the infamous Fire Extinguisher scene.
- Antichrist: With the exception of Händel's "Lascia ch'io pianga", used in the prologue and conclusion, the soundtrack consists entirely of drones.
- In The Dark Knight, the Joker's leitmotif is a dissonant droning which sounds like running a razor across a piano string.
- Terminator:
- In The Terminator, a frightful metallic-sounding droning theme plays as the Terminator prepares to shoot Sarah Connor in the night club.
- In Terminator 2: Judgment Day, a terror-inducing droning sound plays in the background whenever the T-1000 makes an appearance.
- John's Carpenter's The Thing (1982) makes heavy use of minimalist drones to evoke apocalyptic dread. The political/sociological documentary The Power of Nightmares borrows from The Thing's soundtrack.
- The use of a crescendo-going ominous drone in the very first seconds of There Will Be Blood quickly established the strange nature of the movie.
- The ominous drones denoting the presence of evil spirits in The Evil Dead (1981).
- The theme for the Emperor becomes very creepy due to the droning chorus.
- Peter Gabriel's soundtrack for "The Last Temptation Of Christ" had a lot of this. Peter even Lampshaded it in an interview at the time, saying that his rule of thumb while composing the soundtrack was "When in doubt, Drone."
- Repeated drones were used in the trailer for Transformers: Revenge of the Fallen.
- Lockdown's leitmotif in ;;Transformers: Age of Extinction'' has a prominent one. Because being an Implacable Man, Hero Killer and Knight of Cerebus all rolled into one wasn't enough.
- Used very effectively throughout Inception to solidify the "wrongness" of the dream worlds.
- Used repeatedly in the German film Das Experiment (The Experiment).
- This short film.
- Goblin's soundtrack for Dawn of the Dead is full of this trope.
- Several parts of the soundtrack to Close Encounters of the Third Kind use drones reminiscent of the aforementioned Gyorgy Ligeti; e.g., the piece when the aliens emerge from the mothership at the end is similar to "Requiem", the Monolith music from 2001.
- This is practically a Characteristic Trope for David Lynch, typically used to make something mundane suddenly terrifying.
- Beyond the Black Rainbow has drones often.
- Basically all of the score to Martha Marcy May Marlene.
- Used in The Hurt Locker when the main character finds a cord on an IED that reveals a daisy chain of about 8 more
- Other than the slow Psycho Strings below the opening credits, and some music performed onscreen by the characters and then under the end credits, this is Martha Marcy May Marlene's only soundtrack.
Live-Action TV
- For some reason, TCM (Turner Classic Movies) has seen fit to accompany the rating cards before each movie they show with one. The effect is unintentionally unnerving.
- The end music of each episode of The Shadow Line is the siren drone of doom, but high pitched instead of low. It's singularly disturbing.
- Law & Order makes extensive use of this (at a low pitch) when the (usually disturbing) key relevation comes out, either on the witness stand or (better yet) in chambers or an interview room.
- György Ligeti's compositions spanned a large array of different styles, but some of them featured really prominent drones, notably the pieces Requiem and Atmospheres (both heard in 2001: A Space Odyssey). The former combines drones with Ominous Latin Chanting, and the latter features the largest cluster chord ever written, with every note in the chromatic scale over a range of five octaves being played at once that's 60 different notes.
- L'Étoile du Matin Noir, an EP of dark ambient and noise music featuring many drones, released for free under Creative Commons.
- Most of 16 Horsepower's output is ominous to begin with, but when David Eugene Edwards breaks out his Chemnitzer concertina or hurdy-gurdy, the ominousness gets cranked up to 11.
- Ditto Woven Hand, Edwards' followup music project. He frequently plays drones underneath the main melody, to make these already-menacing songs even more so.
- Calibretto's "American Psycho" uses a sustained organ drone for an effective Last Note Nightmare.
- The entirety of drone metal. Especially Sunn O))), the Trope Codifiers, whose music is horror incarnate. link.
- John Cale tends to carry this with him wherever he goes.
- Some ambient music is based around sounds like this.
- In particular the dark ambient artist Lustmord, who uses the aforementioned infrasound in his music to incredibly unsettling degree.
- Jack Dangers' album Music for Planetarium.
- Most pieces by Greg Davis (an ambient artist, not to be confused with other musicians of the same name).
- Both albums by Dilate.
- "You Can't Cool Off In The Mill Pond You Can Only Die" by John Fahey (not Blind Joe Death) adds throat singing for more drone.
- Xera's "Inda" starts off with a rather creepy, minute-long drone performed on a rabel.
- Norwegian duo Röyksopp have this hidden track on their album 'Senior': [1]
- Klaus Schulze's "Wahnfried 1883", especially the beginning and ending, and the intros of "Echoes of Time" and "Solar Wind" from the Special Edition of Timewind.
- Bull Of Heaven.
- Some of Autechre's ambient works, such as "Paralel Suns", which sounds like Silent Hill ambience, "Perlence Suns", and "Perlence Subrange 6-36".
- Robert Fripp and Jeff Fayman's 2000 collaboration A Temple in the Clouds uses "Frippertronic" guitar drones. link
- "Modern Ruin Part 2", the Hidden Track on Covenant's Modern Ruin album (only on the CD, not the digital release). Reminiscent of the forementioned Quake soundtrack, as well as the nightmare hospital ambience in Silent Hill. Likewise for "Cryotank Expansion" from their first album. The opening track of Skyshaper, "Ritual Noise", starts with a siren-like drone.
- Some Throbbing Gristle material, such as "Slug Bait" and the legendary "Hamburger Lady".
- blowupnihilist use these in many of his works, as heard here, and on the Objective Nothingness EP.
- Several songs by Nine Inch Nails, including "Sanctified," "Something I Can Never Have," "Even Deeper," and the ending to "Hurt."
- Fever Ray's If I Had A Heart, used as the main theme for Vikings.
- They Come Out at Night by Eschaton combines drones with jungle beats.
- Nurse with Wound, especially the minimalist album Soliloquy for Lilith
- A lot of Black Metal bands like this a lot. Some examples are Deathspell Omega, Blut aus Nord, and Weakling.
- Post-Rock band Godspeed You! Black Emperor have always used this trope a fair amount (the intro to "The Dead Flag Blues", the mid-section of "Sleep", etc.), and its prominence in their music has increased with time. Two tracks on each of their two latest albums consist almost entirely of drone.
- Fuck Buttons prominently utilize drones in Sweet Love for Planet Earth, OK, Let's Talk about Magic, Race You To My Bedroom / Spirit Rise, Colours Move, and Brainfreeze.
- The last of the six Sea Interludes in Britten's opera Peter Grimes (and the only one not available in a concert version), "Fog", sustains one fifthless dominant seventh chord quietly for several minutes under various orchestral laments and outbursts.
- In Trouble in Tahiti, a low held note on the cello fluctuates in volume as Dinah and Sam, not looking at each other, despair of reconciling.
Video Games
- Heard in multiple locations in Blood.
- Quake has a soundtrack featuring many creepy drones, composed by Trent Reznor.
- Fallout, epically with the songs composed by Mark Morgan, notably in City of the Dead, Vats of Goo, and Industrial Junk. Likewise for Gold Slouch from Fallout 2.
- Fallout: New Vegas has a number of original drone ambient tracks, such as Garden of Evil (Dungeon 6) and Boys & Ghouls (Dungeon 8)(especially disturbing when heard in the Divide), as well as reusing many from the first two games.
- This is the entire basis of the award-winning sound design in the Silent Hill series. When there isn't all that scraping crashing metal or absolute silence, there's usually low drones of things along the lines of, for example, deepened breathing sounds on the streets of the fog town in the original game. "Black Fairy" from the second game's otherworld hotel, with its Giygas-style distorted drone chords accompanied by a periodic screeching sound, ranks as one of the most horrifying music pieces in video game history. On a similar level of horror is the high-pitched ringing drone that accompanies the lethal red light at the end of the Borley Haunted Mansion.
- Used commonly throughout the Thief series in certain segments of its ambient/atmospheric music. Particularly in scary missions.
- Doom 3's soundtrack and ambient sound design is composed largely of subtle drones.
- Oracle Of Tao has mostly okay music. But a few of the songs are Brown Note material. Especially this one. If you pregnant, nursing, or hell just don't want a stomach ulcer, don't listen to this music.
- Used for macabre effect during the first couple of blocks of Eldritch Location Tartarus in Persona 3, since you're venturing into the unknown in a place crawling with metaphysical manifestations of the human psyche. The effect goes away as you climb more floors and more and more instruments are added to the piece, and by the time you reach block 6 it's a complete composition.
- Pokémon Yellow's version of Missingno causes the battle music to become dead static. Not quite a drone, but close and creepy as hell.
- As for deliberate musical uses, the Distortion World theme in Platinum features a lot of drone.
- Kyogre's theme in Sapphire can be described as "wow, things look pretty bad right now". Groudon's theme in Ruby can be described as "the sky is on fire and we are all going to die".
- The opening menu music for Warcraft III: The Frozen Throne.
- In The Legend of Zelda: Majora's Mask, the final boss theme features an eerie droning tune in the background.
- The Day 3 Clock Town theme also has ominous low tones, which makes the cheerful melody from Days 1 and 2 sound pretty darn creepy.
- Two words: Ikana Valley.
- The Fire Temple (v 1.0) music from The Legend of Zelda: Ocarina of Time combines this with Ominous Arabic Chanting, somewhat reminiscent of the aforementioned "Requiem" from 2001: A Space Odyssey.
- Some of the dungeon soundtracks in The Legend of Zelda: Twilight Princess.
- Yasunori Mitsuda's soundtrack for Xenogears has two of these: "The One Who Is Torn Apart" and "Omen". There's also "Jaws of Ice" which mainly focuses on two slowly-alternating tritone drone notes for a particularly unsettling effect.
- Several pieces in Halo 2, eg the first and last parts of "Sacred Icon Suite", use choral drones. The first game has "Suite Autumn"(even creepier in the remake), the bass drone in The Gun Pointed at the Head of the Universe, the middle of "Truth & Reconciliation Suite", which also uses Psycho Strings, "Lament for Pvt. Jenkins", and parts of "Library Suite" (remastered as "Dewey Decimate" in Anniversary). Also, the first half of "Nightfall" in Halo: Reach. Other reworked ambient tracks in Halo: CE Anniversary that turn the creepiness factor Up to Eleven include Unfortunate Discovery (originally What Once Was Lost) and Bad Dream (originally Trace Amounts).
- The Resident Evil games like to use this, for example:
- "The Second Floor", "Wandering Alone", and "The Underground Laboratory" in Resident Evil 2.
- "Feel The Tense" and "Never Give Up The Escape" from Resident Evil 3: Nemesis.
- "Deathtrap", "Lost in Darkness, "Narrow and Close, "Rush of Fear" and "Rush of Horror" from the Resident Evil remake.
- Resident Evil 4, while more actionized, still has a plethora of scary drone pieces, especially Ruined Village, Noche(heard when first encountering a Plaga), Bitores Mendez(combined with Psycho Strings), Cold Sweat(combined with Heartbeat Soundtrack), Novistadors, and *cough* *cough* Regenerador.
- Most of the ambience in Twisted Metal: Black fits this trope, but Snowy Fields is the epitome of terrifying drone.
- Pressure Road from Ys II, and Sanctuary from Ys IV: The Dawn of Ys.
- The World 4 background music from Super Mario Galaxy 2.
- Also, the meteorites Mario/Luigi uses to fight Bowser.
- The Big Boo's Haunt theme from Super Mario 64.
- Amongst the Dead from Medal of Honor: Underground uses this alongside Psycho Strings, Ethereal Choir, and For Doom the Bell Tolls. Also, Passage to Iraklion, and Rescuing The G3 Officer from the first game.
- The Airbase ambience in Syphon Filter 2.
- The Aljir prison music was even better.
- Several of the background songs from Yume Nikki, like the appropriately named "Hellish Hum".
- DayZ has its entire soundtrack as this, and its pure, unadulterated, terror. The best part is the music always seem to come up at the worse moment, making nearly every situation incredibly tense and every player paranoid of what's around the corner.
- Mass Effect 3 gives the Reapers a chilling BWWOOOAAARRMM when they arrive. It's part of the soundtrack too. The Reapers actually use this with this trope in mind. The sound is there for the purpose of putting fear into their enemies.
- An unintentional example is the Level 3 music in "Lollipops" from Action 52. Listening to it in a ROM utility is scary enough, but that's nothing compared to how it sounds in-game (skip to 3:17).
- A staple of the FEAR soundtracks: Insertion, Initiation, She's Afraid of You, Bad Water, Armacham Rooftops, Premonition, Distorted Realities, et al.
- The Medusa Bay theme from Ecco The Dolphin uses creepy sitar-like drones, which adds to the desolate feeling. Undercaves also has a droning bassline.
- The Mars Underground and Shield Generator ambient sounds in The Journeyman Project have this effect, and to a lesser extent the background hum in the TSA.
- In P.N.03, the Final Boss's scorpion form uses this.
- The Phazon Mines, especially Level 2(from 0:50 to 2:16), in Metroid Prime.
- The Suspense music in Wolfenstein 3D, although it's only FM synth MIDI, has a drony bass section.
- "Prologue" from Super Castlevania IV, especially the beginning. An SNES game, no less.
- The level "Dark Side Part Two" in Duke Nukem 3D includes The Monolith as an homage to 2001, complete with similar drony music/sound.
- The scary or suspenseful tunes in the When They Cry series use this often, like in Depressive Paranoia or Stupefaction.
- Oblivion's theme in Turok 2: Seeds of Evil(N64 version only).
- The infamously scary Giygas battle music in Earthbound.
- The soundtrack for the Soul Cairn (plane of the undead) in The Elder Scrolls V: Skyrim consists of Drone of Dread and more Drone of Dread.
- Some night overland themes for the regular Skyrim world contain this, too.
- The final boss theme (appropriately named "Crocodile Cacophony") from Donkey Kong Country 2 combines this with a techno beat.
- The mission "Remember... No Russian" from Call of Duty: Modern Warfare 2 has a particularly unsettling droning bass line playing throughout the whole level. One variation of this, appropriately titled "Airport Stalk", also plays during the Terminal Spec-Ops mission.
- The music in Hotline Miami switches to rather unsettling droning ambiance after a mission is completed, helping to unnerve the player and keep them on their toes even after everyone's dead which comes in handy in one mission when a van crashes through the entrance on your way out and tries to run you over.
- The gameplay soundtrack of D/Generation is pretty much this exclusively.
- In Project Firestart, one plays occasionally to add tension to the otherwise still ambiance, such as when Jon first arrives on the Prometheus.
- In Chrono Trigger, when you enter Magus's castle there is at first no music, then when you proceed deeper into the castle this song plays. It is entirely a Drone of Dread, with only one violin chord and a half-laugh, half-sob sound effect repeated throughout. The battle music doesn't play when you encounter monsters, and an echo effect is added on to any sounds produced by the fighting.
- Far Cry 3: Blood Dragon's soundtrack has a number of drone tracks, notably "Helo 73", "Moment of Calm", "Dr. Elizabeth Darling", "Sloan", and "Nest".
- System Shock 2 has dark ambient hums and occasional thumping noises lining almost every bit of the Von Braun and Rickenbacker spaceships. Sometimes it's obviously coming from computers or industrial machinery nearby, but other times...you can't really tell at all what's making those noises. And to top it all off? Even the main menu has a low electronic drone to it.
- In Luna Game 3, the music changes to a Giygas-esque drone after the slowdown and white noise Scare Chord. note
- In Vanquish, the Romanov-Gs' One-Hit Kill super missiles emit a droning sound.
- Max Payne 3's ambient soundtrack, produced by the noise rock band HEALTH, makes good use of both guitar and electronic drones.
Web Comics
- The track Crystamanthequins from Homestuck is mostly defined, early on, by a harsh, droning note intermixed with a heavy drumbeat and high-pitched synth wails, although the drone dissolves towards the end. In the comic itself, it's used for [S] Make Her Pay, which depicts the most significant points in the troll Cycle of Revenge.
Web Original
- Used in this adaptation of a Fuan no Tane segment.
- Homestar Runner. When Coach Z discusses his "Rapping Paper" costume for Decemberween. Lampshaded by Homestar when he suggests the group groan again.
Western Animation
- This trope is part of the appeal of The Hypnotoad from Futurama. Interestingly, it was originally just a placeholder sound until they found something better, but they decided it was just so wrong sounding that they had to keep it. According to David Cohen, the name for that particular sound effect in the editing machine is "Angry Machine."
- Used with [adult swim]'s sign-off bump, "The Dawn is Your Enemy".
- The Legend of Korra adds it to the soundtrack during season 2 with the Northern Water Tribe's invasion of the South Pole, among other instances. It also has an in-universe example: dark spirit Vaatu's Wave Motion Eye Beams go accompanied with a thrumming bass roar, similar to the Mass Effect example above.
- In Book Two's finale, the drone also features prominently in the soundtrack during the Dark Avatar's attack.
- The drone appears again in-universe during book four when Varrick's experiment with a spirit vine produces a similar blast of energy. His tech is weaponized against his will by Kuvira for her conquest and then mounted on a 25-story mech. It's heard many, many times during the series fianle two-parter.
- Appears various times in Thomas the Tank Engine, particularly in the more electronic-sounding early episodes. Combined with Psycho Strings in Season 2's "Ghost Train"


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.: The Secret Path :. by Pure-Poison89Watch
©2012-2016 Pure-Poison89
You have amazing taste in creative art~
This is very beautiful and dreamy! You made a wonderful job with the lighting!
رووووعه ماشاء الله : )
You have created another magical piece. I love the way the fairies are almost hiding like the little girl. Great light coming from the moon to light little patches enough to show almost magical surrounding. You did a really good job on this piece it does have a magical touch.
Dygyt Alice
Dygyt Alice
I LOVED IT!! soooo dreamy <3333333333333
This is fantastic mashallah! Awesome idea I it so much! Love the dreamy and fantasy atmosphere <3
Great work........!!!!!
i missed ur work! but im glad ur back now : D
love this <3
love this <3
i love the idea of a portal to anther world .
Always so gorgeous~ feels like seeing a dream hehe
Awesomesauce! I love it!
Speechless, wow this is amazing <3
The Fireflies are a nice touch.
Beautiful work !!
Thank you for using my stock!!
Thank you for using my stock!!
you're amazing ^^ !
you're amazing ^^ !
Very beautiful
great work


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Another term has begun....Journal Entry: Tue Jan 8, 2013, 10:42 AM
I write this journal as a kind of heads up apology to those of you who are expecting a drawing from me with the art exchange meme. Since winter term has started I will be distracted easily by school work and may take a long time to get to where i have enough free time to draw. Though I'll try to get some drawing done when i can.
Skin by COMMANDER-C
Another term has begun.... by KuwathenWatch
©2013-2016 Kuwathen


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In addition to credit cards,
we also accept Paypal & Google Wallet.
The FINIS® Jellys Kids Goggle is a perfect goggle for kids new to the water. With its smaller size and fun color combinations, it creates a watertight yet comfortable seal no matter how hard they play. With every FINIS google purchase, you donate to the FINIS So More Can Swim Initiative.


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Natalie Portman has been confirmed to attend this year's BFI London Film Festival to promote her new ballet movie 'Black Swan'.
Natalie Portman will attend the BFI London Film Festival.
The Hollywood actress - who is one of a host of stars lined up for the prestigious event - will show her movie 'Black Swan' directed by Darren Aronofsky, in which she plays a troubled ballet dancer.
Women are set to dominate this year's event as stars led by Julianne Moore, Hilary Swank will be joined by a record number of female directors.
The programme unveiled today (08.09.10) boasts a strong female presence with 57 women directors for the 197 feature films and 112 shorts.
Artistic director of the 54th BFI London Film Festival Sandra Hebron, said: "From the playful to the precise, the surreal to the stringently social-realist it's hard to recollect a year when the programme has been quite so diverse.
"Well known and highly regarded directors including Mike Leigh, Ken Loach, Catherine Breillat and Errol Morris sit alongside iconoclastic provocateurs Takashi Miike, Jean-Luc Godard and Gregg Araki."
Screenings and events take place from October 13 to 28 in various cinemas across London.


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MMA H.E.A.T.'s Karyn Bryant talks with welterweight Richard Walsh and hears what he has to say about his upcoming UFC 184 fight with Alan Jouban. Richard discusses the stylistic match-up, the fight watch video >>
Eternal MMA 1 highlight reel from our first event. Southport Sharks club in Queensland Australia was host to Eternal's first pro - amateur cage fighting event. Fighters from all over Australia conver watch video >>
We steal a boat, throw our friend overboard, eat raw tuna and troll for sharks in my newest video blog from Thailand. watch video >>


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The Kast off Kinks are former members of The Kinks who got together to play for Kinks Fan Club meetings and Charity events over 15 years ago.
The current lineup decided to take the band to the fans across the country. They are Mick Avory, original drummer, who played on all the classic hits from 1964-1984. Bassist, Jim Rodford 1978-1996 (also known for Argent and the current Zombies). Ian Gibbons, keyboardist, 1979-1996, currently still working with Ray Davies' band and Dave Clarke, on vocals and guitar, previously with The Beach Boys and the Noel Redding band.
'A full house, and a standing ovation. To anyone wondering about going, do not hesitate' (The Stables, Milton Keynes)
'Nothing short of superb. From start to finish it was a set filled with hit after hit' (Mad Ferret, Preston).
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Saw them in Worcester 23rd Jan 2010. fab .all the old songs and you can sing along as if it was yesterday!!! great sound from each of the group. would go again tomorrow!!! Waterloo Sunset was the best!!! plus a calyso type one I didn't now!!! and the rest..… (cont'd) Pauline from Kidderminster
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9 items from 2015
30 September 2015 2:39 AM, PDT | Den of Geek | See recent Den of Geek news »
Meet some of the best directors working today, who haven't gone down the blockbuster movie route...
Ever find it a bit lame when the same big name directors get kicked around for every high profile project? Christopher Nolan, Jj Abrams, maybe the Russo Brothers? With so much focus on blockbuster films these days, getting a major franchise job seems like the main acknowledgement of success for a filmmaker. And yes, both the financial and creative rewards can be great. But there are plenty of other directors out there, doing their own thing, from art house auteurs to Dtv action specialists.
Here are 25 examples.
Even if you don't know his name, you've probably seen Lee Hardcastle's ultraviolent claymations shared on social media. He first started getting noticed for his two-minute remake of The Thing, starring the famous stop motion penguin Pingu. Far from just a cheap one-joke mash-up, »
- simonbrew
29 July 2015 8:07 AM, PDT | Thompson on Hollywood | See recent Thompson on Hollywood news »
The first image is up from writer/director/cinematographer Sean Ellis' ("Metro Manila," "Cashback") "Anthropoid," now filming in Czech Republic. Set in 1941, the World War II picture stars Cillian Murphy and Jamie Dornan and centers on the real-life assassination attempt on SS general and Holocaust engineer Reinhard Heydrich. The film follows two Czech paratroopers tasked with taking out Reinhard, known in their homeland as "The Butcher of Prague." Read More: Netflix War Drama 'Jadotville' Lines Up Macho Cast "Anthropoid" is written by Ellis and Anthony Frewin ("Colour Me Kubrick") and produced by 22h22's Leonard Glowinski, Anita Overland, Chris Curling, Krystof Mucha and David Ondricek. »
- Ryan Lattanzio
29 July 2015 4:54 AM, PDT | Variety - Film News | See recent Variety - Film News news »
London – The first image has been released from the World War II movie "Anthropoid," which is headlined by "Fifty Shades of Grey" star Jamie Dornan and Cillian Murphy. Director Sean Ellis is shooting the film on location in the Czech Republic.
New cast members to sign up to the production include Toby Jones ("Infamous," "Tinker Tailor Soldier Spy"), Harry Lloyd ("The Theory of Everything," "Game of Thrones"), Bill Milner ("X-Men: First Class," "Son of Rambow"), Alena Mihulova ("Krava," "Nevinnost") and Sam Keeley ("Adam Jones," "Jadotville"). They join the previously announced cast members Charlotte Le Bon ("Yves Saint Laurent," "Bastille Day") and Anna Geislerova ("Something Like Happiness," "Zelary").
The movie is set in 1941, when Czechoslovakia was occupied by Nazi forces, governed by SS General Reinhard Heydrich, nicknamed "The Butcher of Prague." His reign of terror against the Czech resistance led Allied authorities in London to hatch a mission to assassinate him. »
- Leo Barraclough
17 May 2015 6:45 AM, PDT | Variety - Film News | See recent Variety - Film News news »
In the beginning, things went a bit differently than the Good Book would have us believe — or at least, that's the playful conceit behind Jaco Van Dormael's "The Brand New Testament," an irreverent (but otherwise harmless) ontological satire that puts a cartoonish spin on the Christian origin story. Incidentally, Van Dormael has volunteered an alternate creation myth of some kind in all four of his features (which also include "Toto the Hero," "The Eighth Day" and "Mr. Nobody"), only this time, the Belgian idea-meister goes as far as to target God directly, "outing" Him as kind of a jerk who lives in Brussels and sits at His personal computer, conjuring natural disasters as a way of staving off boredom. When his daughter rebels and decides to simultaneously enlighten everyone on earth, all hell breaks loose, and the narrative starts to lose its thread, unspooling zany consequences that ought to convert skeptical distributors worldwide. »
- Peter Debruge
3 March 2015 12:33 AM, PST | JoBlo.com | See recent JoBlo news »
It's been announced that Fifty Shades Of Grey actor Jamie Dornan will star opposite Cillian Murphy in Anthropoid, a World War II thriller from Cashback director Sean Ellis. Dornan and Murphy will play a pair of Czech soldiers who were involved with the 1942 assassination of high ranking Nazi official Reinhard Heydrich, also known as "The Butcher of Prague." Sean Ellis co-wrote the script with novelist and former Stanley Kubrick assistant Anthony Frewin, and the »
- Jesse Giroux
2 March 2015 10:56 AM, PST | The Wrap | See recent The Wrap news »
"Fifty Shades of Grey" star Jamie Dornan is striking while the iron is hot, so to speak, as he has signed on to star opposite Cillian Murphy in the World War II thriller "Anthropoid," it was announced Monday. Sean Ellis ("Cashback") will direct the film, which examines the assassination attempt on Nazi general Reinhard Heydrich, aka "The Butcher of Prague," who many believed would succeed Adolf Hitler. Dornan and Murphy will play a pair of Czech soldiers tasked with the deadly mission. Also Read: 'Fifty Shades' Sequel? Universal Not Talking but There Are 245 Million Reasons to Say Yes Ellis co-wrote the. »
- Jeff Sneider
2 March 2015 9:35 AM, PST | Thompson on Hollywood | See recent Thompson on Hollywood news »
Irish actor Jamie Dornan, currently on the big screen in "Fifty Shades of Grey" and on Netflix's moody crime drama "The Fall," has yet another project on his busy horizon. Dornan is set to star opposite Cillian Murphy in Oscar-nominated director Sean Ellis' ("Cashback," "Metro Manila") World War II picture "Anthropoid" about the real-life assassination attempt on SS general and Holocaust engineer Reinhard Heydrich. The film follows two Czech paratroopers tasked with taking out Reinhard, known in their homeland as "The Butcher of Prague." This year, Dornan will also shoot Netflix-acquired historical drama "Jadotville" as a Un commander who fell under siege in the Congo in 1961. The film debuts on the streaming service in 2016. Dornan also has roles in two films currently in post: an untitled John Wells chef comedy and Alexandre Aja's mystery-thriller "The 9th Life of Louis Drax." And of course, »
- Ryan Lattanzio
2 March 2015 4:05 AM, PST | Us Weekly | See recent Us Weekly news »
Not just a one hit wonder! Coming off of the success of Fifty Shades of Grey, leading man Jamie Dornan has already been cast in a new film. The Irish actor, 32, who portrayed kinky billionaire Christian Grey, will next appear in a World War II drama Anthropoid, The Guardian reports. Dornan will play a Czechoslovakian soldier involved in the real-life assassination attempt on SS officer Reinhard Heydrich. The film is being directed by Brit Sean Ellis, who is best known for his independent films Cashback and [...] »
2 March 2015 1:51 AM, PST | ScreenDaily | See recent ScreenDaily news »
Exclusive: Sean Ellis to direct, Cillian Murphy to co-star in assassination film.
Jamie Dornan and Cillian Murphy are to lead cast in WWII thriller Anthropoid, about the attempted assassination of prominent Nazi official Reinhard Heydrich.
The film's title refers to the code-name for the Allied operation to assassinate Heydrich, the head of the SS who was one of the main architects of the Holocaust and was widely considered number three in the Nazi ranks behind Hitler and Himmler .
Operation Anthropoid was led by two soldiers (trained by British forces) from Czechoslovakia's army-in-exile who were parachuted into their homeland to carry out the mission against the Nazi nicknamed "The Butcher of Prague".
Oscar and BAFTA-nominated British filmmaker Sean Ellis (Metro Manila, Cashback) will direct from a script co-written by Ellis with Anthony Frewin (Colour Me Kubrick: A True…ish Story).
Producers are Leonard Glowinski (The Diving Bell and the Butterfly) for 22h22, Anita Overland ([link »
- firstname.lastname@example.com (Andreas Wiseman)
9 items from 2015
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To the degree we have a government that protects our rights to engage in commerce freely and fairly, each individual does have "a chance to get ahead," to earn a living through hard work. The problem is that Mr. Obama favors a government that not only does everything for us, without some of us having to work hard (or at all), but that also stands in the way of people — especially poor folks — entering the marketplace and expressing their entrepreneurship.
Regulations obstruct us — but obstruct the poor even more. Mandates and minimums (such as higher minimum wages) require too much, prohibiting the achievable. Taxes and licenses and all other weapons of modern bureaucratic governance are going strong, too strong, even as the economy falters. The problem with recent times is not that we've had too much freedom in markets. It's that we haven't had laissez-faire at all. (To pretend, either from the left or the right, that because Ronald Reagan said he liked free markets, and because Bill Clinton said "the era of Big Government is over," that we've had limited government since is absurd. Counterfactual. A fantasy.)
And over and over we hear of all the benefits we can reap if only the government taxes the rich more. This is the envy part. The malice. It is there to distract our attention away from what we can do to better ourselves.
It also tempts us to the worst elements of socialism — the mass expropriation that historically has even led to mass murder ("liquidate kulaks!"; "eat the rich!"; "kill the Jews!") — and derails the kleptocracy from the tricky calculation of thieves' canny wisdom: you don't want to run out of victims. But a robust "social democratic" state can indeed run out of such folks. At least, run out of enough rich victims to satisfy the demands of a growing legion of moochers.
And, of course, the anti-capitalism of this all forgets where capital is (those who own it and invest it), and that taking it and turning it all into consumption can kill the "material productive forces" upon which we all rely. Pure socialism doesn't work for the same reason pure thievery doesn't work. Taking capital from the capitalists and squandering it on consumer items liquidates the capital and, in the end, makes us all the poorer for it. If not dead.
President Obama wants to assure us that he's not a pure socialist. I sure hope so. But he's pure something, and the something he and his followers are for is not as good as freedom and responsibility.
Stop feeding envy. Or covetous vice. We've a lot to gain: social peace, personal pride, greater wealth, and, yes, freedom.
Famed Voting Rights/Anti-Poverty Activist Fannie Lou Hamer Called Abortion "Genocide" | Ryan Bomberger
Rush Limbaugh defends Rubio's debate answer: He's absolutely right that Obama knows what he's doing | Allahpundit
Time for Team Hillary to break out the gender card for young liberal women who prefer Sanders | Allahpundit


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Harley F. Merithew
unknown - November 23, 2012
Harley F. Merithew, 75, of Wildwood, Fla., passed away Nov. 23, 2012.
Harley was born on May 13, 1937, to Claude and Ida (Steacy) Merithew. He attended Canton ATI (SUNY Canton) and Syracuse University. He began his working career at the Crouse-Hinds Co., Syracuse, which later became part of Cooper Industries. He moved to Baldwinsville in 1971. In 1983, he was named product manager for Cooper Lighting and moved to their headquarters in Vicksburg, MS.
Harley was a member of St. Paul's Church in Leesburg, Fla., and St. Patrick's Church in Colton N.Y., He was a member of the Third and Fourth Degree of The Knights of Columbus. He served in various capacities and offices, including Deputy Grand Knight for Baldwinsville Council No. 5082. Harley was affiliated with St. Mary's Scout Troop No. 119 in Baldwinsville for five years, serving as scout master for two years.
As well as being an avid "flea marketer," he especially enjoyed woodworking. Harley loved nature, canoeing, camping and hiking. He had an eye for spotting the rare bird, animal, etc., much to the delight of his family. For a number of years he was a member of the New York Air National Guard and was activated into the U.S. Air Force during the Berlin Wall crisis, becoming one of the "Boys from Syracuse" spending 1961-1962 in Phalsburg, France.
He is survived by his wife of 49 years, Katherine (Edgerton) Merithew and two children, Patrick J. "P.J." Merithew and partner Carrie Bryant of DeKalb Jct., N.Y., and Theresa "Tracy" (Anthony) Corpus of Goose Creek, S.C., four grandchildren, Marie, Rhys, Sage and Tony, his father, Claude Merithew, two sisters, Doris (James) Smith and Geraldine (Richard) Fletcher and numerous nieces and nephews. He was predeceased by his mother in 2000 and a nephew, James Smith, in 1977.
Services were held at St. Patrick's Church, Colton, with burial at The Union Cemetery, DeKalb Jct., N.Y.
Use the form below to express your condolences.


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Ask the Experts
Oral Sex and Dry mouthI would like to know if there is any link to oral sex and dry mouth i gave a man oral sex for just a few minutes he did not cum in my mouth. That same day and for the following week i had terrible dry mouth and a white tongue i have never...
Response from Ryan M. Kull, C.S.W
Columbia University's Health & Related Services...that he did not cum in your mouth greatly reduces your risk for infection. I am not aware of any information that suggests a dry mouth would increase the risk of transmission for the person performing oral sex. Maybe your white tongue is simply... Read more »
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What Are the Symptoms of HIV and AIDS?...injection drug equipment, especially needles if you're a baby, being born to or breastfed by an HIV-positive woman unprotected oral sex (if you're providing the mouth; this is a much lower risk than the others) That's it. For any other type of... Read more »
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Some Info on ARS, Seroconversion and the Rest
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scared what if driving me nuts...
Posted by sadman, 3 Replies...hours prior) but there was a band aid on ti. The cut finger never touched her. The reason I ask is 15 days out I got a dry mouth a sore throat and a swollen lymph node on my neck. I got all the STD screens I could this early on and all... Read more »
HIV from oral sex when u have dry lips (Accutane)?
Posted by Anonymous, 3 Replies...even have herpes 1 breakouts on my lips because of accutane (thus my lips get very red and sometimes bleed). So I performed oral sex about 3-4 weeks ago on a complete stranger and now Im worried my lips might have been dry and sore that night... Read more »
I really need answers
Posted by Anonymous, 2 Replies...Psychosomatic Illness? I cannot sleep at all. And I take a few Tylenol PM's to help me sleep. It did once then I woke up with a dry mouth. I have had no swollen glands or diarhea or aches or pains as such. But my tongue feels very dry and has... Read more »
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