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Best-Ever Grilled Cheese Sandwiches Recipe
For a classic grilled sandwich, this recipe is the best. You can also use your imagination for other fillings, such as a sprinkle of Parmesan cheese, Italian seasoning, chives or even a tiny spoonful of salsa. —Edie DeSpain, Logan, Utah
- 2 tablespoons mayonnaise
- 1 teaspoon Dijon mustard
- 4 slices sourdough bread
- 2 slices Swiss cheese
- 2 slices cheddar cheese
- 2 slices sweet onion
- 1 medium tomato, sliced
- 6 cooked bacon strips
- 2 tablespoons butter, softened
- 1. Combine mayonnaise and mustard; spread over two bread slices. Layer with cheeses, onion, tomato and bacon; top with remaining bread. Spread outsides of sandwiches with butter.
- 2. In a small skillet over medium heat, toast sandwiches for 2-3 minutes on each side or until cheese is melted. Yield: 2 servings.
Nutritional Facts
1 sandwich equals 714 calories, 48 g fat (23 g saturated fat), 111 mg cholesterol, 1,291 mg sodium, 41 g carbohydrate, 3 g fiber, 29 g protein.
Reviews for Best-Ever Grilled Cheese Sandwiches
© 2016 RDA Enthusiast Brands, LLC


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subset: commoncrawl


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The JD Guide offers information regarding studying postgraduate law at Monash University. Back by popular demand, it is now in its fifth edition. The Guide not only provides useful factual information it also provides insightful first hand student accounts of opportunities available to JD students. This Guide will be useful to students commending the JD, as well as students who are ready to graduate from their degree at Monash.
Suggestions and contributions are always welcome for future editions of the Guide and may be made to: [email protected]


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Demolition Derby
Demolition Derby – FREE Grandstand Seating! Saturday, August 1, 2015 at 7 p.m. 2015 Demolition Derby Entry Form – Rules & Regulations Entry Form Locations
We have something for everyone! Be sure to check out our 2015 Concert Series too!
FREE Grandstand Seating for all events!
Demolition Derby – FREE Grandstand Seating! Saturday, August 1, 2015 at 7 p.m. 2015 Demolition Derby Entry Form – Rules & Regulations Entry Form Locations
Harness Racing is held on the track at the Free Grandstands. 2015 Schedule Saturday, July 25 at 11 a.m. – 3 Year Old Classic Monday, July 27 at 11 a.m. Tuesday, July 28 at 11 a.m. – featuring the Maple City Trot
Motorcycle Races – FREE Grandstand Seating! Saturday, August 1, 2015 at 11:00 a.m. Sign-up begins at 9:00 a.m. Practice begins at 10:00 a.m. Practice ends at 10:45 a.m. (Sharp)
Tractor Pull Day is Thursday, July 30, 2015. FREE Grandstand Seating. Farmstock Tractor Pull begins at 8 a.m. Lucas Oil PPL Tractor & Truck Pull begins at 12 p.m. Show will continue into late evening.
9/11 Never Forget Exhibit: The Siller family started the Stephan Siller Tunnel to Towers Foundation to honor the memory of their brother, Stephen, a New York firefighter who lost his life Sept. 11, 2001 after strapping on his gear and running through the Brooklyn Battery Tunnel to the World Trade Center. The foundation's mobile exhibit […]
Dinner in the Park presented by Tom Naquin: Fairgoers can enjoy their favorite fair food under the park sail in Heritage Park while jazz bands play and roving entertainers — a magician, mime and balloon artist — entertain diners from 5:30 p.m. to 8:30 p.m. Friday, July 24 & Saturday, July 25.
Visit the Draft Horse Barn – Open Daily Featured 2015 Hitches: TBA Scheduled Hitch Times: Friday, July 24: 5:30 – 7 pm Saturday, July 25: 5:30 – 7 pm Monday, July 27: 5:30 – 7 pm Tuesday, July 28: 5:30 – 7 pm Wednesday, July 29: 5:30 – 7 pm Also: Hitches are Featured in […]
Sunday, July 26, 2015 The Elkhart County 4-H Fair Parade is a much anticipated community event. No other event brings the community together like the parade. Attendance is in the tens of thousands along the three mile parade route. For over 40 years the parade has been sponsored by the Goshen Noon Kiwanis Club. The theme of this year's parade […]
Located in Youth Ag Education Center a must do for every kid when you visit the Fair. Open Daily from 9 a.m. – 9 p.m. Sponsored by KeyBank
Sunday, July 26, 2015 Heritage Park Stage – Elkhart County 4-H Fair 2 pm & 5 pm – Adam's Voice: David and Charlene Adams sing familiar gospel songs and originals written by Charlene. They have been featured on Christian television shows and have sung the National Anthem at NFL and Major League Baseball games. 3 pm […]
All Week – July 24 – August 1. Open Daily 11 a.m. – 9 p.m. Jayco Family Fun Center Sponsored by: Jayco
Miracle of Life Calving Center Located in the Youth Agricultural Education Center Open Daily!
Pop-Up Restaurants located in the Youth Ag Garden Schedule Friday, July 24 – 5:30 – 8:30 pm Saturday, July 25 – 5:30 – 8:30 pm Wednesday, July 29 – 5:30 – 8:30 pm
Open Daily from 9 a.m. – 9 p.m. Free event for toddlers – 8 years old. Near Young MacDonald's Barn in the Youth Ag Center.
The Wild World of Animals: Its unique blend of animal diversity and environmental messages coupled with humor will entertain fairgoers every day of the fair. Daily Shows at 3 p.m., 6 p.m. and 8 p.m. in the Family Entertainment Center.
The Xpogo Stunt Team: The best extreme pogo performance team in the world uses next-generation pogo sticks to bounce nine feet in the air while performing flips and tricks. Their amazing stunts will happen July 24 and 25 on the basketball courts. Basketball Courts Friday, July 24 – 2:00 pm, 5:00 pm & 7:00 pm Saturday, July […]
Young MacDonald's Barn Located in the Youth Agriculture Education Center See young animals up close and learn about their care from veterinarians. Open Daily from 9 a.m. – 9 p.m.
Daily Shows in the Youth Agriculture Education Tent "Thank a Farmer" Magic Shows Friday, July 24: 1 pm, 3 pm, 5 pm Saturday, July 25: 11 am, 1 pm, 2 pm, 5 pm Sunday, July 26: 11 am, 2 pm 4 pm Monday, July 27: 3 pm, 5 pm, 7 pm Tuesday, July 28: 1 pm, […]
3 on 3 Basketball Tournament This is a single elimination tournament. Participants will need to pay gate admission if they do not already have admittance (4-H pass, pre-sale ticket etc…) to the Fair. gate admission will be provided if you make it to the finals. Information and Registration
Saturday, July 25, 2015 Registration begins at 11:30 a.m. Competition 12:30 – 4 p.m. Held in Heritage Park on the Activities Pad. Sponsored by: Bail Home Services
The Cheerleading Competition is held on the grandstand stage. FREE Grandstand and Track Seating! Friday, July 24 at 1 p.m. 2015 Cheerleading Registration Waiver / Release of Liability – Signature required for all Participants 2015 Spirit Squad Score Sheet 2015 Competition Score Sheets 2015 Cheer Program
Saturday, August 1, 2015 Held in the S/S Arena Check-in 10 a.m. – Noon Show Time: Noon -3 p.m.
2015 Elkhart County 4-H Fair Queen Pageant Friday, July 24 @ 8 p.m. 2015 Queen Pageant
7th Annual Kid's Fun Run! Sunday, July 26, 2015 at 1:00 p.m. Open to ages 3 – 12 years Kids have the option of 1 lap around the Track (1/2 mile) or 2 laps around the Track (1 mile). Register Now Online Register at the Fair Office thru Saturday, July 26. Register Race Day 11:30 […]
Parade 5000 Road Run – Sunday, July 26, 2015 The Parade 5,000 race will be run along the Elkhart County Fair Parade route with thousands of spectators. The course is very flat and fast. Be sure to hydrate the day before and morning of the race if hot temperatures are forecasted. Plan on spending your […]
Senior Citizens Talent Competition will be held Tuesday, July 28 at 11 a.m. on the Heritage Park Stage. The 11th Annual Senior Talent Competition is sponsored by Greencroft Goshen. 2015 Contest Registration
37th Anniversary – Senior Queen Pageant NEW TIME Friday, July 24, 2015 at 5:30 p.m. Fair Features Blog Post – 2015 Senior Queen Pageant More information
Strongman Competition Saturday, July 24 at 9 a.m. Register Online Strongman Results 2015 Keg Carry Results Log Flip Results Obstacle Course Results Tractor Pull Results Strongman Final Results
Youth Talent Competitions are held on the Heritage Park Stage. Registration will be held at 5:30 p.m. each night. Junior Division – Tuesday, July 28, 2015 at 6 p.m. Senior Division – Wednesday, July 29, 2015at 6 p.m. UPDATE: You still have time to sign up for Youth Talent Contests! Applications will be now be accepted […]


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Search Results Type: Posts; User: tfodge
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It seems there have been many attempts to make BSN the entry credential for practice. I know this failed and was overturned in North Dakota. Can anyone tell me whey it failed and provide with book...Oct 8, '09
- Forum: General Nursing Discussion
I'm in the same boat. I have also been surfing the internet trying to find information on why the attempt failed in North Dakota. I do know it was overturned in 2003. Anyone out there have...Oct 8, '09
- Forum: North Dakota Nursing
Absolutely not. Like the above person I also graduated at the age of 51. I love it. The years go buy very fast. Soon enough you will be 40. Are you just going to be 40 or are you going to be 40...Oct 8, '09
- Forum: General Nursing Discussion


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On Tuesday, April 30, the New York chapter of Einstein's National Women's Division hosted its 59th annual Spirit of Achievement Luncheon at New York's Plaza Hotel. Nearly 400 of New York's most prominent women attended the luncheon, which annually honors outstanding individuals in the arts, media, business, philanthropy and government.
This year's honorees were Liz Lange, the noted designer, businesswoman and author, who launched her iconic maternity line in 1997 to become the go-to brand for expectant mothers; Anne Wojcicki, co-founder of 23andMe, a groundbreaking personal genetics and biotechnology company, and co-founder of the Breakthrough Prize in Life Sciences, the world's largest academic prize for medicine and biology; and Dr. Francine Einstein, a member of the College of Medicine's faculty who is a leading expert in the field of maternal and infant health.
For the fifth consecutive year, the ever-popular Willie Geist, of MSNBC, donated his time and talent to serve as the flagship luncheon's emcee. In addition, as part of the festivities, guests were treated to an exclusive fashion show, courtesy of 25 PARK, the go-to boutique for discovering amazing new designers alongside well-known favorites that was hosted by Emmy-Award winning television personality, New York Times best-selling author and fashion expert Jill Martin.
All proceeds from the event will help advance cutting-edge research studies in breast, ovarian, uterine, and cervical cancers conducted by leading scientists at Einstein's Albert Einstein Cancer Center.
View photographs from the luncheon.
Einstein's The Doctor's Tablet Wins Top Honor
Wednesday, July 29, 2015
Author Discusses Resources that Aid Global Health Efforts
Wednesday, July 29, 2015
Two Esteemed Professors Receive Tenure
Wednesday, July 22, 2015
Dr. Calderon Receives Leadership Award from the National Hispanic Health Foundation
Tuesday, June 30, 2015
LCME Affirms Accreditation for Einstein
Friday, June 26, 2015
Exhibit Addresses Initiatives Aimed at Global Health and Health Inequity
Friday, June 19, 2015
Commencement Celebrates New Doctors and Scientists
Wednesday, June 03, 2015
Marmur Symposium Honors Innovative Graduate Student Research
Tuesday, June 02, 2015
Nepalese Student Aims to Help Her Homeland
Friday, May 22, 2015
Receiving Top Honors at National Conference
Friday, May 08, 2015


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|Winter Ontario Day Trips and Getaways to recreation areas north of Toronto, including Family Day, March Break and Holiday Cottage Country Resort Vacations.
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Ontario Resort Destination Parks
Parks in Ontario resort destinations offer some of the best travel experiences at a reasonable price. The park attractions offer outdoor recreation activities--some are FREE. Visitors on vacation north of Toronto have a number of spectacular provincial and national parks to visit.
Best Ontario Parks in Resort & Cottage Country
Many spectacular park areas are must see attractions on a day trip during your resort family getaway or romantic vacation north in Ontario. Each yearCanada's Parks Day is the third Saturday in July where a number of parks hold special events and activities. Some offer free admission or free activities. Parks Canada offers free admission on Canada Day.
Algonquin Provincial Park: See Algonquin Area for places to stay & towns to visit
Awenda Provincial Park: Some of Georgian Bay's best beaches. Midland Ontario road trip
Georgian Bay Islands National Park: Stay in Honey Harbour-Port Severn
Wasaga Beach Provincial Park: Stay in Wasaga Beach area
Parks with admission costs
Most provincial and national parks have admission fees. Parks Canada runs many National Historic Sites, some of which charge an admission fee.
Camping at parks
Most parks offer camping on site for visitors wanting to make the day trip into an overnight experience. Check reservations for provincial parks and reservations at national parks. If you prefer private campgrounds we suggest the following camping and RV resorts. Also check the updates on our member camping getaways.
Parks with no admission costs
There are many park areas, municipal forests, nature reserves available for outdoor recreation use at no charge.
National Parks in Ontario
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ArbitraryDescriptor wrote: »
Casting:Spoiler:Bran will very probably be doing some tree-waging based on young Hodor/Ned/Brandon casting rumors.
how deep would snow have to be forSpoiler:theon/reek/sansa to survive that drop
I thought that bit was confusingly shot.
Spoiler:Suicide seems to make sense given their situation and also the height of the drop. But it was pretty abrupt if that was actually what they intended to convey--major character deaths get milked a little more than that. So I assume that they must have been going for a snowbank.


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When you sold your house...(17 Posts)
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Taken at unknown, USA in .
Marga McKenna was a professional harpist who studied under the famous Carlos Salzedo. SHe played with the NBC Philharmonic orchestra. Her life ended tragically at age 23 by non hodgkins lymphoma. She left behind her parents,sisters ,brothers, a husband and a beautiful 11 month old baby girl named Marga Love.
- Album: All photos
Added by Kristin Roca


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Finally, I am able to spell the real name for the next version of Office: 2007 Microsoft® Office system.
For those of you who have not seen the press passes and want to catch-up here is a list with some of them:
See the 2007 Microsoft Office System Pricing and the 2007 Microsoft Office System Packaging.
Maybe you have heard that this is the biggest release of the decade, and I can tell you that this version of Office has great potential as a development platform. Lots of features/enhancements were announced on Beta 1 and for Beta 2 there are more cool surprises waiting to be announced.
My latest experiment with 2007 Microsoft® Office :) is exporting an ASP.NET 2.0 GridView to Excel 2007. If you use the following code snippet, you will be able to export the content of a SqlDataSource (used to DataBind a GridView) to Excel (without automation):
We built a Web based application for MSDN content management, and we export reports to Excel 2003 using the previous snippet of code. One thing that we don't like is that we lose all formatting, so we have the data, but then we have to make it pretty again.
I ran the same process on a machine where I have the last build of 2007 Microsoft® Office and Excel 2007 is smart enough to keep my formatting. Another cool enhancement. For those of you who have Beta 1, please give it a try.
This still doesnt work for me. It worked in Excel 97 but in Excel 2007 I keep getting the error
The file you are trying to open, <filename>, is in a different format than specified by the file extension. Verify that the file is not corrupted and is from a trusted source before opening the file. Do you want to open the file now? <Yes> <No> <help>
The only difference in code is that - I was also doing
Response.AddHeader("content-disposition", "attachment;filename=somename.xls");
I an experiencing the same problem... It looks like Office 2007 issue (doesn't seem to me to be fixed :-()
Looks like this will not be fixed in the final release version.
Hi! The above codes will produce a prompt box asking me whether I would like to "Open", "Save As", or "Cancel", can you suggest how can I go about avoiding the propmt box? Thank you!
Rename the export file to .xlsx and your problem is solved.
But I don't know whether my clients will have Office 2003 or Office 2007 installed. If I just name the file ".xlsx" then my downloads won't work for many clients. Is there any way to have the client machine check which verison of MS Office is opening up and determine the file extension on the fly based on that?
I'm with Shira. That's not much help at all.


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|Selected FAQ
One of my colors is missing. What should I do?
Calibrate colors in the driver setup to the specific application or image. Set to Default and adjust from there. If the color is still missing perform selftest (Press Load/Eject and power printer on) and check that seven colors are produced. If seven colors are not produced, print default settings (Press Economy/Condensed and power printer on) to inspect dots. If test print shows missing dots, perform two cleaning cycles; (COLOR Cleaning) Press the PAUSE Button, then, Alt and Pause 'OR' (BLACK Cleaning) Press the PAUSE then, Alt and Pause. Run the selftest again to see if printing has improved (Power on the Printer while holding down the Load/Eject Button. If the selftest shows no dots of one of the four colors, try replacing the ink cartridge. If the condition persists, have the printer sent in for repair.


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Release Year: 2006
Psych Summary:
During his childhood, Shawn Spencer developed a remarkable talent for noticing the tiniest of details under the guidance of his policeman father, Henry. However, upon growing up he found it difficult to get a job, and spends most of his time using his skill to give the police anonymous tips. However, the tips are so good that some cops become suspicious that he is involved with the crimes himself. To clear his name Shawn finally settles on a career: he pretends to be a psychic. No one really believes him, but he continues to be so helpful to the police that they keep calling him in on cases they can't solve. Shawn soon brings his childhood friend Gus into his scheme, and between their bantering they manage to solve every case they're presented with.


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Any help would be great! Thanks!
Any help would be great! Thanks!
My dad and stepmom named my sister Mady because they liked Madyson but really liked it because they loved the name Mady...if that makes sense? I love the name Elsie, but SO thinks it's too much like a nickname
Miss Hailee Ann *8-5-09*
Baby #2 due *January 27, 2013*
Kayla and Kacey...in love since October 28, 2006
I think Ellie sounds fine as a name! You could even name her Elizabeth and call her Ellie.
I have a niece named Ellie Grace we all love her name and call her by first and middle! Super cute name! :)
This is too funny! I posted this exact post when I was pregnant with DD. Eliana, Eliza, & Eleanor were all we could come up with but we went with Evelyn and call her Evie.
Check out my cute hats :)
I like Ellie all by itself! I teach and have had many students named Ellie with no longer name. It is such a cute name!


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Behind a curtain of professional neutrality, conference interpreters dedicate themselves to their art with the utmost passion.
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Are you eligible for training? What skills are required? Where can you train? What makes a good interpreting course?
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Interpreters work behind the scenes at a variety of international events, including diplomatic encounters, business meetings or scientific congresses, bridging cross-cultural divides.
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I still haven't even seen most of **Wave 2** in person yet, let alone being able to buy them. I'm starting to wonder if they ever really existed. It's a good thing I'm not interested in the gold/silver editions.
If I can't just casually walk into a store, pick up figures, compare paint-jobs, and casually walk to the check-out line, then I'm not interested. "Hunt The Amiibo" is one game being released by Nintendo that I have no interest in playing.


text:
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Though its spec sheet doesn't quite measure up to that of competing pico projectors, the WowWee Cinemin Swivel's unique design and its inclusion of an adapter for iPhones and iPods make it an appealing choice.
Pricing not available
Want your apps to know which screen orientation you want them using, without having to adjust it each time? Try this app.
The sequel to the N1 has a new 16-megapixel swivel camera with an electric motor that can be controlled by finger gestures or the O-Click accessory.
SwivelCard, a business card that folds into a USB drive, directs recipients to a Web page and can be updated, even after you've handed it out.
Got Gear? Get the most from Samsung's virtual-reality headset by leveraging these five simple tricks -- many of which apply to Google Cardboard as well.
The electronics manufacturer announced that it sold 50 million phones in 2015, which makes it the world's 8th largest maker of mobile phones.
The Chinese phone maker is ready to start selling its distinctive flagship smartphone -- the camera is on a pivot. The N1 also has a 5.9-inch screen, but no LTE support.
Oppo's latest smartphone brings hardware innovations to a new Android 4.2 phablet.
The LG Pouch with Swivel Clip and Wristlet offers a stylish and convenient way to protect and carry your new LG Chocolate.
Pricing not available
It's not the sleekest tablet around, but the Revolve is a very nice little laptop for businessfolk, if you can forgive its older processor.


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Published on April 2nd, 2013 | by NSB Observer0
Daytona State Foundation Encourages Students to Apply for Scholarships
DAYTONA BEACH – While federal financial aid is available to eligible students, scholarships are often overlooked as a funding source and, in some cases, can make the difference in a student's ability to pursue a college education.
Financial Aid Services at Daytona State College provides many resources to help students with their scholarship search. In addition to completing the Free Application for Federal Student Aid (FAFSA), new and returning students should also plan to apply for Daytona State College Foundation donor scholarships, available online at www.DaytonaState.edu/
For summer classes starting May 20 and July 1, scholarship applications are available now through April 12, 2013. Students will be notified in May if they have received a scholarship. For fall scholarships, students should check the college's website for beginning dates for scholarship applications, expected mid-May.
For additional information, visit Financial Aid Services online, www.DaytonaState.edu/finaid.


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Tuesday, June 12, 2012
5 comments
I had a leg workout scheduled yesterday which does not include cardio since the leg workouts leave you feeling shakey by them selves, but I had a very hard time combating the negative self talk yesterday. I was "somewhat" successful food wise, s... Read more
Monday, June 11, 2012
1 comments
And epic fail. Im like a waterfall over here. Yesterday I expected a slow star but its been like a faucet that wont turn off, although normal for what im going through (first one since December 2010) not fun. The hormone part is no fun and I for... Read more
Sunday, June 10, 2012
3 comments
I would like to send out a formal appology to all the people in the world who ate clean before me. I used to laugh at you, thinking you were nuts and starving yourself on iceburg lettuse. I thought your food choices were strange and you were con... Read more
Saturday, June 09, 2012
3 comments
i have 4 nephews and today my sister is throwing my oldest nephews party (he will be 9 at the end of the month but are doing it early to have school friends). Oh joy. Here we go again, crap food, stress about bringing my own food, no one talking... Read more
Friday, June 08, 2012
3 comments
So I know I already blogged this morning, but i just had to add this here. My new routine is working out thekins...I get up in the morning do stretches and strength, then I eat fruit and protein, blog and then cardio (about 30 min after eating s... Read more
Friday, June 08, 2012
5 comments
Despite my kids having wonderful behavior I feel like I yelled at them all day. Today will be different, and im just waiting for "shark week" (as my friend calls it, im stealing this). I have not had a regular period since giving birth to my sur... Read more
Thursday, June 07, 2012
4 comments
So with both kids home all day (my oldest now on her summer break) I am trying to find a new routine that works. Instead of being able to workout after dropping Mollie off at school around 9:30 I am trying to do all my working out before they wa... Read more
Wednesday, June 06, 2012
5 comments
Well I learned on my trip i cannot be trusted (YET) with cheese or nuts. I weighed out perfect portions of each to help supplement for snacks since I needed meals that were easy to carry around while I was in NYC walking. I was prepared but a si... Read more
Tuesday, June 05, 2012
4 comments
Drove home from NYC laste night, only took us about 8.5 hours! Great time! Im not sure where to start. We had a wonderful time. We were there for a Bat Mitzvahbut snuck up a day early (without telling anyone) so we could have an entire day in NC... Read more
Thursday, May 31, 2012
1 comments
So sinc eI returned from LA 2 weeks ago I have been on estrogen patches. Let me tell you I have been loopy and cranky, emotional and starving! Not a good combination for me a self admitted food addict. Yesterday I was totally famished, shaking i... Read more
Wednesday, May 30, 2012
4 comments
So i take my girls to the park yesterday. The sun was out, it was hot, and I needed to get out of the house after the packing frenzy had begun! There was one other mom and her little girl almost 2. So after about an hour the dark clouds rolled i... Read more
Tuesday, May 29, 2012
2 comments
I know its tuesday, but with the long weekend the whole day is going to feel like Monday! I need to stay cognisent of the fact it is Tuesday since I have tons to pack and get ready for my road trip on Friday. Basically I have 3 days! O My just t... Read more
Monday, May 28, 2012
7 comments
I had a huge accomplishment today. I ran for the first time ever. I went early morning by myself (since hubby was off for the holiday) to a local lake trail. I think its is around 2.5 miles around. I ran the whole damn thing! I was just so proud... Read more
Monday, May 28, 2012
8 comments
I prep everything. I have cut veges (peppers, celery, cabbage, summer squash, zucchinni, onion) in a seperate container in the fridge for easy grabbing to make salads. Every morning after I eat my breakfast, I prep (weigh out precooked steel cut... Read more
Sunday, May 27, 2012
4 comments
For me it is all about control. I want to and try to control everything. In times I am not in control I freak OUT, stress and worry about the situation and then turn to food. Because after all what I put in my body is something I can control, so... Read more


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Alfred.tay Nov 26, 2013 6:48 PM
in response to ghazala13
I have attemted many times and finally solved this problem. I'll share my story of the whole process, perhaps you'll find some parts useful.
I bought my new iMac i7 Haswell machine and gave a score of 11 out of 10. It's beautiful. But for work purposes, I need to install Windows. So I heard good things about Windows 8.1 and tried bootcamp. I successfully partitioned 2TB for Windows 8.1 and left 1TB for Mac without problem.
I am quickly dissapointed with Windows 8.1 and decided to install Windows 7. However in Bootcamp Assistant, the option to remove Windows 8.1 is greyed out. I read many forums, from old to new, I decided to erase that partition using Disk Utility. But after doing so, Bootcamp Assistant still doesnt allow me to install Windows because the harddisk has to be singleton (without partition). Disk Utility is not able to combine the two partition for some reason. So after lots of googling, I manage to remove the partitions (Windows and a small partition for windows systems) using gParted, from http://gparted.org/ (download the ISO and burn into a CD)
However, for some reason, Disk Utility is still not able to combine the partitions I erased. The partitions are some how arranged in an order with the Mac Partition sitting in the middle of two. eg. Partition 1, empty, Partition 2, Mac, Partition 3, empty. With lots of frustration, I decided to wipe everything using gParted again and then I manage to combine all partitions.
I reinstalled OS X using USB created using DiskMakerX. This time Bootcamp Assistant gave me this error message. "Startup disk cannot be formatted...". I tried using cmd+R during boot and Disk Utility to review and repair multiple times, erase and reinstall multiple times, all failed. I also tried to remove the Recovery partition using commands in Terminal to get that final 600mb partition into the "singleton" hoping that Bootcamp Assistant will work. But unfortunately it doesnt work either.
At that time I totally gave up and start using VMware with half the processing power. Then, for some reason, I decided to wipe the hdd again, this time, I did not choose "1 partition" in the partition tab. I realised I am so focus on getting it back to a singleton, everytime I erase, I make sure I selected "1 partition". I simply click the main hdd and click erase. I use this picture from Wikipedia for example.
I just clicked the "465.8 GB ST3500641AS Q" and clicked "erase". In the "Evolution" partition, there will be just one partition and labelled "Current".
I reinstall OS X again and then Bootcamp Assistant works again.


text: I Love Perfume Mes Parfums Preferes My favouirte scents are - Light Blue - Dolce & Gabbana Red Door - Elizabeth Arden J'Adore - Dior Flower - Kenzo Envy Me - Gucci Mediterranean - Elizabeth Arden Very Irresistible - Givenchy crazedfilth 26-30, F 0 Nov 11, 2011 SEND TO A FRIEND: Me Too Your Response Please respond with authenticity, support, and respect Cancel You can join Experience Project now! Username: Password Email Birthday Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec Gender Select Male Female Trans* Already a member? Sign In By clicking "Sign Up", you confirm that you agree to the Terms of Service of Experience Project, Inc. Login Login to respond Username: Password: Keep me logged in Not a member? Sign Up Sign Up Cancel


text:
Do Not Pass Go 2 by The-StarhorseWatch
©2012-2016 The-Starhorse
Masterfully told! Really nice arrangement and again snappy dialogue!
This problem could be easily solved with a Prowl Plushie.
Or, you know, convincing Hasbro to make that TF Prime Prowl into a toy. Whichever is easier.
Or, you know, convincing Hasbro to make that TF Prime Prowl into a toy. Whichever is easier.
Dang Mirage, somebody crapped the bed this morning.
XD Ahh... Mirage that handsome bastard.
poor Jazz! I love the emoticon at the end -- he has a visor and its brilliant!
poor jazz
They don't ASK you to make other versions? My Movie Jazz wouldn't give me any peace until I made him a Prowl--and he came out pretty good--and then yelled at me for delivering him unto Jazz.
Yeah, well---maybe it doesn't work out so hot...
Yeah, well---maybe it doesn't work out so hot...
Aww poor Jazz. *huggles*
I wonder how Mirage manages to not get punched in the face everyday.
Oh Primus this will not go over well...XD I can't wait to see how they mess everything up! Yay!!! X3
You're half way there Jazz, You made it into the yard
Maybe a friendly corgi will give you a lift into the house
You're half way there Jazz, You made it into the yard
Maybe a friendly corgi will give you a lift into the house
Mirage...you're so mean...-__- Poor Jazz. Prowl hasn't been in recent TF video games so unfortunately I don't think Prowl will be in Fall of Cybertron. The only hope poor Jazz has is if Hasbro decides to make a FOC Prowl just to sell figures. Good luck Jazz! I hope you get in ^^
Maybe he can team up with a Bot Shots Prowl?
Maybe he can team up with a Bot Shots Prowl?
wow, Mirage sure knows how to make a bad first impression
Jazz is growing more and more annoyed lol
:C poor guy he needs a hug
well, guess mirage threw the ticket for jazz into the house out of the window!
Ohhh, the usually calm Jazz is loosing his cool; that's never good! Wonder what he'll do?!
awww but I feel with Mirage, no one wants to be seeked up as the second best thing
This is adorable!
Wainting for more!
poor fall of cybertron Jazz
"poof be gone" holy crap that took me back to like 3rd grade! this was the laugh i needed today
Poor Jazz.
Come over to my place, Jazz. The only ratio we keep around here is Moar Jazzes:1 Rusty.
angry pitter-patter is angry
Aw, poor Jazz. First Red Alert, now Mirage...that mech just isn't having a good day, is he?
And it's remarkable how long Mirage's been holding that grudge. XD
And it's remarkable how long Mirage's been holding that grudge. XD
pooor jazz, he should draw a pic of a prowl and be done with it XD
Well, Mirage doesn't really need a Jazz, all he needs is a Hound.
Forget another Transformer, Jazz!!!! Get a cat instead!!!!!
hmm what would happen if the new Jazz takes one of the Puggle Prowls, since they don't have Jazzes X3
First, Red should have known better than to try and keep a Spec Ops out. Doomed to failure from the start.
Second, OH 'RAJ!
Second, OH 'RAJ!
... I'll draw him a Prowl so he's not gonna be alone anymore!
Mirage . . . *shakes head*
Mirage, you can be such a jerk... yet we still love you. Great shots here.
*chuckles* Oh Mirage, he's a new Jazz - start fresh!
aww Jazz. Mirage...be nice.
Mirage...don't be so mean
Aww poor Jazz hopefully he'll get a Prowl soon
Don't worry Jazz, Mirage is gonna piss off the wrong bot ONE day.
hehe man Jazz isn't having much good luck lately. X3
poor Jazz...and Mirage, your grudge-holding is impressive!
hope there's a FOC Prowl for him
*opens purse* hop in jazz ill get ya in ^_^
Oh poor Jazz. I wanna give him a hug so badly right now. ;w;
I also love these comics.
I also love these comics.
Are these those Cyberverse figures? Because a mini Mirage just sounds awesome.
Hey, Jazz, I have a spare Prowl! x3 Also, can I hug you?
"No Buts. I am not currently in the market for a Jazz. You may go."
hahahahahaha oh that is just fantastic. Mirage you are fantastic, don't ever change.
hahahahahaha oh that is just fantastic. Mirage you are fantastic, don't ever change.
As adorable as this comic is... I feel a bit bad. Why? Because the biggest laugh I got was from the artist's comments. ^_^U (Mainly because I'm like that too! LOL!! )
Aww,poor FOC Jazz,I'll get you into the house.


text:
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text:
In mybook®: Pets
Malu Pet Bliss Limited Liability Company
3138 Waialae Ave Apt 909, Honolulu, HI 96816
REVIEWS(1)Top ▲
Recommended for All Pet Parentsby petlover1 on 09/01/2007
Malu Pet Bliss has the most caring and professional pet sitters I have ever met. The owner Tonya truly redefines pet sitting. You should feel confident booking your next vacation or working long hours away from home knowing that you leave them in the best of hands.
PEOPLE ALSO VIEWEDTop ▲
KEAUNUI Drive, Ewa Beach, HI Pet Grooming, Dog & Cat Grooming & Supplies, Aquariums & Aquarium Supplies, Dog & Cat Furnishings & Supplies, Pet Food, Pet Stores
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Achilles K9
Pet Services, Dog Training, Pet Grooming, Pet Specialty Services, Pet Stores, Pet Training, Mobile Pet Grooming
MORE STUFF NEAR YOUTop ▲


text:
Book your room at Apasari Krabi
Superior RoomMax Occupancy: 3 guests (up to 2 children)
Deluxe RoomMax Occupancy: 3 guests (up to 2 children)
Get an overview of this hotel3.5-star hotel near Ao Phra Nang Beach
Collect 200 points
Simply enter your Nectar card number when prompted. Your points will be credited 30 days after you return from your trip.*Offers may apply
Located in the heart of Krabi, this hotel is 0.8 mi (1.3 km) from Ao Phra Nang Beach and 0.8 mi (1.3 km) from Nopparat Thara Beach. Ao Nang Krabi Boxing Stadium and West Railay Beach are also within 2 mi (3 km).
Hotel Features
A restaurant, an outdoor pool, and a poolside bar are available at this hotel. Free WiFi in public areas and free self parking are also provided. Additionally, massage/treatment rooms, spa services, and a children's pool are onsite.
Room Amenities
All 70 individually furnished rooms feature WiFi and minibars. Guests can enjoy deep soaking tubs, and other standard amenities include balconies, refrigerators, and flat-screen TVs.Information missing or incorrect? Tell us!Opens in a new window
Hotel Amenities
Hotel Amenities
Apasari Krabi features an outdoor pool and a children's pool. The hotel offers a restaurant. A poolside bar is on site where guests can unwind with a drink. High-speed wireless Internet access is complimentary.
This Krabi hotel also offers spa services, tour/ticket assistance, and dry cleaning/laundry services. Onsite self parking is complimentary.
- Front desk (limited hours)
- Airport transportation (surcharge)
- Total number of rooms - 70
- Number of floors - 5
- Breakfast available (surcharge)
- Dry cleaning/laundry service
- Elevator/lift
- Pool umbrellas
- Tours/ticket assistance
- Free WiFi
- Limo or Town Car service available
- Spa treatment room(s)
- Poolside bar
- Porter/bellhop
- Luggage storage
- Restaurant
- Pool sun loungers
- Beach towels
- Year Built 2008
- Free self parking
- Number of buildings/towers - 2
- Spa services on site
- Children's pool
- Outdoor pool
- Television in common areas
Family Friendly Amenities
- Family Hotel
- Outdoor pool
- Children's pool
- Free Wi-Fi
- Rollaway/extra beds available
- Refrigerator
Available in all rooms: Wireless internet access ( 200.00 THB per 24-hour period )
Available in some public areas: Free WiFi
Free self parking
Room Amenities
- Balcony
- Air conditioning
- Phone
- Refrigerator
- Minibar
- Free bottled water
- Daily housekeeping
- Private bathroom
- Free toiletries
- Hair dryer
- Deep soaking bathtub
- In-room massage available
- Slippers
- Separate bathtub and shower
- Flat-panel TV
- In-room safe
- Desk
- Rollaway/extra beds available
- Blackout drapes/curtains
- WiFi (surcharge)
- Satellite TV service
- Room service (limited hours)
- Individually furnished
- Rollaway/extra beds (surcharge)
Where to Eat
Buffet breakfasts are available for a surcharge and are served each morning between 7 AM and 10 AM.
Hello Restaurant - Overlooking the pool, this restaurant serves breakfast, lunch, and dinner.
Room service (during limited hours) is available.
Nearby Things to Do
An outdoor pool and a children's pool are on site.
The recreational activities listed below are available either on site or nearby; fees may apply.
- Golfing nearby
- Snorkeling nearby
- Kayaking nearby
- Scuba diving nearby
- Scooter/moped rentals nearby
- Free bicycles nearby
- Boat tours nearby
Spa Services
- Manicures and pedicures
- Body scrubs
- Massages
- Facial treatments
Hotel Policies
Check-in time starts at 2 PM
Check-out time is 11:30 AM
Payment types
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
No pets or service animals allowed
Optional extras
- Fee for buffet breakfast: THB 250.00 per person (approximately)
- Fee for in-room wireless Internet: THB 200.00 per 24-hour period (rates may vary)
- Rollaway bed fee: THB 1000.00 per night
Hotel Name
- Apasari
- Apasari Hotel
- Apasari Hotel Krabi
- Apasari Krabi
- Apasari Krabi Ao Nang
- Apasari Krabi Hotel Ao Nang
We should mention
Reservations are required for massage services and spa treatments. Reservations can be made by contacting the hotel prior to arrival, using the contact information on the booking confirmation. No pets and no service animals are allowed at this property.


text:
Book your room at D-H Calma Hotel
Please enter your travel dates.
Get an overview of this hotelBeaux Arts Playa de Palma hotel in Can Pastilla with indoor pool
Collect 200 points
Simply enter your Nectar card number when prompted. Your points will be credited 30 days after you return from your trip.*Offers may apply
Located in Can Pastilla, this hotel is 0.6 mi (1 km) from Palma Aquarium and within 6 mi (10 km) of El Arenal Beach and Aqualand. Port of El Arenal and Basilica of St. Francis are also within 6 mi (10 km).
Hotel Features
An indoor pool, an outdoor pool, and a bar/lounge are available at this hotel. Additionally, a coffee shop/café, a snack bar/deli, and a sauna are onsite.
Room Amenities
All 190 individually furnished rooms feature WiFi and balconies or patios. For a bit of entertainment, TVs come with satellite channels, and guests will also find down comforters and free local calls.Information missing or incorrect? Tell us!Opens in a new window
Hotel Amenities
Hotel Amenities
In addition to an indoor pool, D-H Calma Hotel provides an outdoor pool and a sauna. Dining options at the hotel include a coffee shop/café and a snack bar/deli. A bar/lounge is on site where guests can unwind with a drink. High-speed wired and wireless Internet access is available for a surcharge.
This Beaux Arts hotel also offers an arcade/game room, multilingual staff, and coffee/tea in the lobby. A total renovation of this property was completed in January 2012.
- Indoor pool
- Outdoor pool
- Arcade/game room
- Billiards or pool table
- Sauna
- Total number of rooms - 190
- Number of floors - 5
- Bar/lounge
- Breakfast available (surcharge)
- Coffee/tea in common areas
- Coffee shop or café
- Concierge services
- Elevator/lift
- Front desk (limited hours)
- WiFi (surcharge)
- Wired (high-speed) Internet access - surcharge
- Multilingual staff
- Free parking nearby
- Beach towels
- Snack bar/deli
- Year Built 1969
- Number of buildings/towers - 1
- Television in common areas
Family Friendly Amenities
- Family Hotel
- Outdoor pool
- Indoor pool
- Rollaway/extra beds available
- Snack bar/deli
- Arcade/game room
- Cribs/infant beds (complimentary)
Available in all rooms: WiFi (surcharge)
Available in some public areas: WiFi (surcharge) , Wired (high-speed) Internet access - surcharge
Free parking nearby
Room Amenities
- Desk
- Television
- Hair dryer (on request)
- Satellite TV service
- WiFi (surcharge)
- Free cribs/infant beds
- Balcony or patio
- Air conditioning
- Phone
- Free local calls
- Private bathroom
- Free toiletries
- Bathtub or shower
- In-room safe
- Rollaway/extra beds available
- Down comforter
- Individually furnished
Where to Eat
Continental breakfasts are available for a surcharge and are served each morning between 7 AM and 10 AM.
Nearby Things to Do
An indoor pool and an outdoor pool are on site. Other recreational amenities include a sauna.
Hotel Policies
Check-in time starts at noon
Minimum check-in age is 18
Check-in time ends at 10:30 PM
Special check-in instructions:
Check-out time is 10 AM
Payment types
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
- Minimum Spring Break check-in age is 21 years old.
No pets or service animals allowed
Noise-free rooms not guaranteed
Hotel Name
- D-H Calma
- D-H Calma Hotel
- D-H Calma Hotel Playa de Palma
- D-H Calma Playa de Palma
We should mention
Cash transactions at this property cannot exceed EUR 2500, due to national regulations. For further details, please contact the property using information in the booking confirmation. Children 3 years old and younger stay free when occupying the parent or guardian's room, using existing bedding. Some facilities may have restricted access. Guests can contact the property for details using the contact information on the booking confirmation. No pets and no service animals are allowed at this property.


text:
Before the invention of the remote control, people had to stand up from the couch, walk all the way across the room, and slip Grandpa a $10 bill just to tell a different story. Upgrade your anecdotes with this Groupon.
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Quick EZ Repairs' technicians can resolve a broad spectrum of electronics emergencies, from broken iPhone screens to the mythical red ring of death—the techs' moniker for the three red lights that signify an Xbox 360 error. Through rigorous examinations and troubleshooting, they return devices to working order and back their handiwork with a 30-day guarantee. In addition to fixing up smartphones, PCs, game consoles, and tablets, the team can recover corrupted files and transfer data from old computers directly into the brains of babies. The shop also includes an extensive stock of new phones, games, and computer accessories.
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721 Hebron Pkwy
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text:
Youthhostel St. Gallen Reviews
- Info
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Reviews & Ratings Explained
The rating percentage is calculated from customers who booked within the last 12 months.
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Great location, just down from the 3 lakes and some walkways that give good views over Lake Constance, and St. Gallen centre is only 20 mins away on foot. Good breakfast. Ok dorm.
- Globetrotter
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- (46 reviews)


text: 1) Use IOS sockets to implement a network driver - How? 2) Use IOS sockets from userspace - Only works with modified programs 3) Write a driver that can send and receive UDP packets using IOS sockets. Implement IP over UDP using TUN/TAP in a similar way to IP over DNS. http://thomer.com/howtos/nstx.html - Requires another computer on the network to act as a proxy + Could work 4) Hope that the IOS interface for sending DS demos is low level enough to do normal wifi. - Requires reverse engineering work - May not be possible 5) Replace IOS - Requires lots of reverse engineering work - Risky 6) Give up and use a USB wifi adaptor -- Malcolm Parsons


text:
286 Views 1 Reply Latest reply: Jun 13, 2012 11:13 AM by mcbuffy
mcbuffy Jun 13, 2012 11:13 AM
in response to Adaklu
It's only to remove a Mac App Store app. If you want to delete an app you didn't download from the Mac App Store you should do it manually (or with the freeware AppCleaner). Drop the application in the trash, look in your Application Support and Preferences folders to find files related to that application. Thos folders are in your-user-name/Library/.
Hope this will help.


text:
Definitions for oil pan
This page provides all possible meanings and translations of the word oil pan
We couldn't find a direct definition for the term oil pan.
Maybe you were looking for one of these terms?
oil of wintergreen, oil paint, oil painter, oil painting, oil palm, oil pastel, oil patch, oil pipeline, oil platform, oil pressure


text:
May 9, 2012
The Seitz Building
Stories this photo appears in:
Former Morris' Grill space to return to use as local pub
Coleman's Pub in Syracuse to branch into Skaneateles
The long-vacant village space that once housed the popular bar Morris' Grill will soon have a new tenant – and it will continue the tradition of being a local village pub. The new owners of the Seitz Building, along with the owner and general manager of Coleman's Authentic Irish Pub in Syracuse, announced Thursday, June 14, that a new venture named The LakeHouse Pub will come to Skaneateles by late summer. Dennis Coleman, general manager of Coleman's Authentic Irish Pub, and two Skaneateles partners, Joseph I. Goethe and Michael I. Wamp, will own the establishment.
Historic Skaneateles building purchased by local developers
Commercial tenants to stay; luxury apartments to be ready this summer
Skaneateles's Seitz Building, in foreclosure since last year, has been purchased by a team of local developers for $2 million.
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(USA & Canada) Call 1 800 745 8883
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Warm hospitality, impeccable service and a genteel atmosphere in the heart of Venice, only a few steps from St Mark's Square.
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Hercules Stands DS501B Velvet Peg for Trumpet / Cornet
Sku #582943000000000
Hercules Stands
Trumpet, Cornet & Flugelhorn Stands
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Hercules Stands DS501B Velvet Peg for Trumpet / Cornet
The peg is lined with velvet to prevent scratches in the bell of either a trumpet or cornet. Specifically designed to fit Hercules Stands.
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Created a great synth or panorama? Shot some great photos? Showcase some of your best work here.
Usually rainbows don't last long, but this one lasted for maybe an hour, nestling between two mountain ridges, fed by raindrops from clouds hanging on a mountaintop.
Charlie I noticed this one a few days ago and favorited it. Great job capturing the scene


text:
Halfords Antifreeze Tester - MEG
Anti freeze and summer coolant should be changed on a regular basis, the Halfords Antifreeze Tester is a quick and easy to use tester, which instantly indicates the level of protection. Simply fill the tester with coolant and number of floating balls indicates the protection level. It is specially designed to test Ethylene Glycol based anti freeze.
Halfords Antifreeze Tester - MEG Extra Info
- Quick & easy to use
- Specially designed to test Ethylene Glycol based anti freeze
- Also suitable for use OAT anti freeze
Additional Information
Always refer to manufacturers recommendations & handbooks
Not suitable for use with methanol based anti-freeze.
Type: Antifreeze Tester
Halfords Antifreeze Tester MEG
Cat code: 527374
Free Click & Collect
Delivery AvailableShow Options
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FREE within 4 working days on all orders over £30 (Halfords products only)
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Morning Delivery£6.99
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ReviewsHalfords Anti Freeze Tester 10 11brilliant Top product value for money, Excellent service and quick delivery. 16 September 2012very useful purchase does exactly what it says. very cheap alternative to dealer and car servicing depots. great little tool, very easy to use. 29 January 2012Engine saver This device is probably fine for most cars, but a tad on the small size for access to the filling cap on my Boxster, although I still just about managed to do the test....but very glad that I did.... I bought the tester because I thought I'd better play safe when I noticed that there wasn't a red or blue hue displaying in the Min-Max plastic window gauge, it was just showing clear! I had only just bought the car (from an obviously useless/ lazy dealer) and began to think that maybe Porsche had some special kind of colourless antifreeze surely - in fact they do have a special antifreeze, but it's actually red as it turns out. The antifreeze mix was indeed on the low side so needed to take immediate remedial action to avoid a potentially and extremely expensive wrecked Porsche engine! So it's clearly a piddling amount to buy this device compared to the consequences of not checking your engine is protected! 28 December 2011Antifreeze Tester Easy to use, results in seconds!! must have!!!!!!! 10 January 2011Freezing reassurance Very useful device to check strength of antifreeze, especially for the price! Could usefully include a rubber extension tube to suck up coolant from big and deep header tanks, though. 20 December 2010Excellent value Brilliant little gadget, does exactly what it says it will do. Takes all the guess work out of knowing whether you have enough antifreeze in your system or not. Great price too 20 December 2010missing plastic tube Only downside to this product was mine came without the little plastic tube to extend its use. This made it difficult to use. Product if as intended is excellent value. 21 October 2010antifreeze tester i have change my antifreeze 2 weekes ago so the test was done we can say on new, fresh antifreeze. Tester showned me the best quality of liquid. works fine 05 January 2010
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Are you Elizabeth Rosvold?Claim your profile
Publications (6)14.23 Total impact
Article: Phase I Trial of Concurrent Hyperfractionated Split Course Radiotherapy (HFx RT), Cisplatin (cDDP), and Paclitaxel in Patients with Recurrent, Previously Irradiated, or Treatment-Naïve Locally Advanced Upper Aerodigestive Malignancy[Show abstract] [Hide abstract]
ABSTRACT: Phase I study to determine the maximally tolerated dose (MTD) of cisplatin (cDDP), paclitaxel (P), and concurrent split course hyperfractionated (BID) RT in advanced squamous cell carcinoma of the head and neck (SCCHN) and other upper aerodigestive tumors. Eligibility stipulated ECOG performance status 0-2 and either Tx-naïve, locally advanced, or locally recurrent, previously radiated, surgically unresectable upper aerodigestive cancer. Metastases were permitted if disease was predominantly locoregional. RT-naïve patients received 150 cGy bid x 5 d Q 2 wks x 4. Previously radiated patients received 150 cGy bid x 5, wk 1; then 120 cGy bid x 5 Q 2 wk x 3 (later increased to 150 cGy BID for the entire treatment). Treatment fields included recurrent tumor only with 2 cm margins. Whenever possible, conventional and 3-D conformal techniques were used. Elective nodal radiation was not administered. Starting doses of cDDP and P were 12 mg/m2/d x 5 and 15 mg/m2/d x 5, respectively, Q 2 wk x 4, each given on RT days only. At dose level 2, cDDP was increased to 15 mg/m2/d x 5. At dose level 3, P was increased to 20 mg/m2/d x 5. Granulocyte colony stimulating factor (G-CSF) days 6-12 (off treatment week) was added if cumulative neutropenia precipitated treatment delays. Results: Thirty-one patients (21 men, 10 women) were treated. Eight had received prior chemotherapy, 27 prior RT. At dose level three, regular treatment delays of >or=1 week due to slow neutrophil recovery occurred. Addition of G-CSF (dose level 3b) reduced treatment delays from 100 percent to 28 percent and decreased the incidence of Grade >or=2 neutropenia and mucositis. Six of 7 patients at this dose level completed all 4 cycles of treatment and all received full dose RT (60 Gy). No other dose-limiting toxicities occurred. Of 22 assessable patients with locally recurrent SCCHN, 12 (55 percent) responded. Median time to progression in this group was 6 months, with median and one-year survival of 9.5 mos and 41 percent, respectively. Concurrent daily cisplatin/paclitaxel and split course hyperfractionated RT (60 Gy) is feasible in previously radiated patients. G-CSF, administered between each cycle, reduces the incidence of treatment delays. Activity is promising and toxicity acceptable.
Article: Induction and Concurrent Paclitaxel/Carboplatin Every 3 Weeks with Thoracic Radiotherapy in Locally Advanced Non–Small-Cell Lung Cancer: An Interim Report[Show abstract] [Hide abstract]
ABSTRACT: The paclitaxel/carboplatin combination has demonstrated promising activity in metastatic non-small-cell lung cancer (NSCLC); therefore, we mounted an exploratory study of these agents with thoracic radiation (TRT) in locally advanced NSCLC. Eligibility stipulated a Karnofsky performance status >or= 70%, weight loss <or= 5%, and primarily stage IIIB or bulky IIIA NSCLC. Induction chemotherapy (CT), 2 cycles of paclitaxel 175-225 mg/m2 over 3 hours and carboplatin (targeted area under the curve [AUC] of 7.5), was administered on days 1 and 22. Granulocyte colony-stimulating factor (G-CSF) 5 microg/kg was given on days 2-15 and 23-36 to all patients; half were randomized to priming G-CSF every day x 5 prior to day 1 of induction therapy. On day 43, TRT (60-63 Gy/30-34 fx) was initiated. At dose level 1, only Fox Chase Cancer Center patients received carboplatin (initial target AUC 3.75) and paclitaxel (67.5 mg/m2 over 3 hours) days 43 and 64. In the absence of dose-limiting toxicity, phase I dose escalation in 3-patient cohorts was scheduled to proceed to a maximum carboplatin AUC 7.5 and paclitaxel dose of 210 mg/m2. To date, 53 patients have received induction therapy; 4 are too early to evaluate. The portion of the study evaluating G-CSF priming revealed no myeloprotective effect, likely due to a lack of myelosuppressive toxicity with the conventionally dosed cohort. Twenty-two patients have received concurrent TRT/CT. In sequential cohorts, the chemotherapy doses on days 43 and 64 have been escalated (to paclitaxel 175 mg/m2 and carboplatin AUC 5) with 1 episode each of grade 4 granulocytopenia and grade 3 anemia. The occurrence of grade >or= 2 esophagitis has corresponded to length (> 16 cm) of esophagus in the radiation treatment field (Fisher's exact test, P = 0.006). The partial response rate to induction therapy was 40% and to the combined modality therapy was 60%. The median survival for all 49 patients is 15.3 months, with a median disease-free survival (DFS) of 7.8 months. In the subset of 22 patients treated on the phase I portion of the study, the median survival and DFS were 18.5 months and 13.5 months, respectively. Induction therapy with paclitaxel and carboplatin followed by concurrent chemoradiotherapy with the same agents is an active and well-tolerated treatment approach in locally advanced NSCLC. To date, paclitaxel 175 mg/m2 plus carboplatin AUC 5 administered at 3-week intervals for 2 cycles is safe in combination with TRT.
Article: Salvage therapy with gemcitabine (Gem) in advanced non-small cell lung carcinoma (NSCLC) progressing after platinum-taxane chemotherapy
Article: Paclitaxel (1-hour) and carboplatin (area under the concentration-time curve 7.5) in advanced non-small cell lung cancer: a phase II study of the Fox Chase Cancer Center and its network[Show abstract] [Hide abstract]
ABSTRACT: We previously reported a 62% response rate and 54% 1-year survival rate for paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) administered by 24-hour infusion in combination with fixed-dose carboplatin to treat patients with advanced non-small cell lung cancer (NSCLC). Myelosuppression proved dose limiting, but was substantially reduced by the routine use of granulocyte colony-stimulating factor during the second and subsequent cycles. Activity for paclitaxel 135 mg/m2 and 200 mg/m2 by 1-hour infusion every 3 weeks in patients with NSCLC, with minimal myelosuppression and the suggestion of a dose-response relationship, has been reported. In November 1994, we initiated a phase II trial in patients with advanced, measurable, chemotherapy-naive NSCLC using paclitaxel 175 mg/m2 given in 1 hour, and carboplatin dosed to a fixed target area under the concentration-time curve of 7.5 every 3 weeks. In the absence of grade 4 myelosuppression, paclitaxel was escalated on an intrapatient basis by 35 mg/m2 per cycle to a maximum dose of 280 mg/m2 by cycle 4. Granulocyte colony-stimulating factor was not routinely used. Of the 57 patients accrued, 44 (81%) are Eastern Cooperative Oncology Group performance status 1. The median patient age is 64 years. To date, 54 patients are fully evaluable for toxicity. In the first 20 evaluable patients accrued (cohort A), myelosuppression was tolerable, but cumulative peripheral sensory neuropathy proved dose limiting: grade > or = 1 in 15 (75%) patients and grade 3 in six (30%), generally occurring at paclitaxel doses > or = 215 mg/m2 and obligating at least three patients to be removed from study despite absence of disease progression. The protocol was consequently revised. The starting dose of paclitaxel was reduced to 135 mg/m2 with intrapatient dose escalations of 40 mg/m2 per cycle, to a maximum paclitaxel dose of 215 mg/m2, recapitulating the original dosing schema used in Fox Chase Cancer Center study 93-024. For the 35 patients enrolled in the second cohort (cohort B), treatment has been better tolerated. Of 21 evaluable patients, 13 (62%) have experienced peripheral sensory neuropathy, grade 3 in only one (5%) patient. Myelosuppression also has been less pronounced, with 44% grade 4 granulocytopenia and 38% grade > or =3 thrombocytopenia in cohort B compared with 70% and 50%, respectively, in cohort A. Of the first 22 patients accrued to cohort A, 12 (55%) had major objective responses. Median event-free survival is 24 weeks and median survival is 47 weeks. Of the 35 evaluable patients in cohort B, nine (26%) have had major objective responses. Median event-free survival is 22 weeks. It is too early to report median survival. Paclitaxel given by 1-hour infusion in combination with carboplatin at a fixed target area under the concentration-time curve of 7.5, although active in advanced NSCLC, is associated with problems that compromise its efficacy. Higher dose levels yield intolerable toxicity, evidenced by the incidence of neurotoxicity (rather than myelosuppression) that was dose and protocol limiting at paclitaxel doses exceeding 215 mg/m2. Lower doses, while more tolerable, appear to be associated with lower response rates.
Article: Chemoprevention of lung cancer
Article: Newer aspects in the diagnosis, treatment, and prevention of non-small cell lung cancer. Part II.
Top Journals
St. Francis Medical CenterДжексон, Louisiana, United States
Fox Chase Cancer Center
Filadelfia, Pennsylvania, United States
- Department of Medical Oncology