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Cotton can turn a cold, wet winter day into absolute misery, but the supremely-warm fleece of the Marmot Men's Reactor Hooded Fleece Jacket won't skip a beat in those same conditions. Worn alone, this jacket has all the features you need to stay comfortable and prepared in cold weather, and when truly brutal cold moves in, wear the Reactor under your shell jacket as an insulator.
- Polartec Classic 100 Micro fabric has a high weight-to-warmth ratio to fight off the cold, and it dries quickly
- Angel-Wing Movement cut gives you ample range of motion in the arms
- Flat Lock Construction eliminates bulging seams that cause annoying chaffing
- Wind flap behind front zipper and chin guard keep your face warm in bitterly cold conditions
- Elastic drawcord hem cinches things up at the waist to lock out chilly drafts
- Reviews
What do you think about this product?
Have questions about this product?
Lightweight and comfy
- Familiarity:I've put it through the wringer
- Fit:True to size
- Size Bought: Medium
Lightweight fleece, nicely cut hood that doesn't drape over your eyes.
Super versatile
- Familiarity:I've put it through the wringer
- Fit:True to size
Love this jacket and it has become a daily wear due to its versatility and comfort. Also great as a base layer for skiing.
Given as a Christmas Gift
- Familiarity:I've put it through the wringer
- Fit:True to size
Purchased for my dad. He's been looking for a hoody which could fit under a coat and this fit the bill. He's been liking it so far; he finds it well-made, warm, and very comfortable. I suspect he cold washes it then puts it to hang dry like he does with most clothes he owns. This is an everyday jacket for him. Highly recommended.
Purchased as Christmas Gift
- Familiarity:I've put it through the wringer
- Fit:True to size
My husband loves this hoody/jacket. He wears it almost everyday (gym, errands, trail walks/hikes). I bought it in cobalt blue. It's well-made, warm, comfy, and has survived a number of washes (cold wash/hang dry) but still looks good. I'm thinking of getting him another one as a back-up ;). My husband is 6ft 2in ~200lbs. and he wears XL.
Made a great gift
- Fit:Runs large
I gave this to my father-in-law for his birthday. Fit is on the large side, he's 5'4" 135 lbs and the small was a little roomy for him. However, he says it super comfy and will help keep him warm in Minnesota this winter.
Very good fleece jacket
- Familiarity:I've put it through the wringer
- Fit:True to size
Very good fleece jacket. Comfortable, soft and pleasant to the touch.
Great product
This was my first Marmot purchase and I couldn't be happier. Light weight, super soft, and like the description says, warmth to weight ratio is wonderful. I'm 6'3, 160 and got the Large. I have monkey arms and this fits great. Loose fit enables me to wear a sweater underneath for apres ski and I'm toasty to temps around 20. Would recommend it to anyone.
simple and versatile
- Familiarity:I've used it several times
This fleece has turned out to be great. I bought it as a backpacking warm layer because of the lightweight and the hood. Even in summer I sometimes find myself wishing I'd brought a warm hat on cool evenings in the mountains. It packs small for it's size, it breathes really well and does a decent job of keeping wind out, as long as you are facing into it, panels only in the front. Reviewer saying it is only as warm as a flannel shirt may not have ever relied on a flannel shirt to keep warm. The warmth to weight ratio is great here. The hood fits close and warms the face and throat without impeding visibility or bothering my chin.The top of the zipper, when open does poke up at a funny angle but is really not a problem.With a light shell over it, it is really warm and comfortable.I have worn it down to about -4c and found it to be warm enough while moving but you would need a shell or more layers below that. Because it works so well and is so comfortable it has become an everday garment, worn to my daughter's soccer games and practices and whatever hiking I can fit in. It fits on the large side for sure. I'm 5'9" 165lbs and got a medium based on the Marmot size chart. I would fit into a small I'm sure but the extra room is not uncomfortable. Better on the big side than the small. Being a Canadian customer I got burned on duty, taxes and had to pay shipping so beware if you haven't purchased anything in a while, some of the policies have changed. Service was great, shipping was fast.
CK Funderburgh
- Familiarity:I've used it several times
Love this Jacket and the fact that it comes in Hokie colors only makes it that much better! I have worn this on 28 degree morning and 60 degree days and it has been great in both conditions!
great as a layer, so-so as a jacket
- Familiarity:I've used it several times
It's very comfortable, and very soft, as others have noted. It fits well, and is nice looking as a standalone garment. I think it's a great layer under my shell, but without, any wind just cuts right through. As far as warmth/weight goes, it's more akin to a hoody than a jacket. Warmth-wise it's like a flannel shirt that You might wear over a t-shirt in the morning until it warms up a bit.
The pocket layout is so-so. The hand pockets are fine, but the upper arm pocket is on the small side. The chest pocket would be much better with outside access instead of hidden inside. That makes keeping your phone or ipod there less convenient.
So, overall, it's comfortable and good looking, but if you really want one I'd try to catch it on sale, because I think at full price there are better values in more versatile jackets.
If you wanted warmth as a jacket the 300 gram jackets do fine without a shell. This puppy was made for layering and as a lightweight warmup. I have one and used as it was intended, it is a beautiful thing to behold.
NOT Over Reacting
- Familiarity:I've used it several times
This is a great little fleece jacket. The 100 micro fleece layers easily when needed and is fairly warm by itself. But the standout thing is the feel. You feel like you have just won the lottery and are walking down a street at night with tons of beautys staring at you when wearing this thing. A work of art. The hood is there for when the winds wake up. Buy this. I am soooo glad I did.
This is by far my favorite warm layer. The polartek wool is amazing and super soft even after countless washes. I've used this as a mid layer under my shell while Skiing and for winter ascents in the Adirondacks and the white mountains. It is tremendous on and off the mountain.
Wow! I love this thing so much I just ordered a second. Extremely warm, fits perfectly under my marmot precip, and looks really awesome too. Amazing fleece mid-layer for autumn hikes, cold fishing mornings, spring skiing, and any other adventure. This is my favorite piece of clothing hands down. I wear it around my house and going out constantly and have had several people ask about it at bars since the fleece is so light/fluffy.
This is a fantastic product: well made, right feel. Bottom Line: It meets my requirements perfectly!
Im 6'5" 260 pounds. I bought a Marmot rain...
Im 6'5" 260 pounds. I bought a Marmot rain jacket in a Xl and it fits kinda tight. What size should I get in this jacket?
six foot 240 pound linebacker type build....
six foot 240 pound linebacker type build. What size should I wear?
You'll be good with the XL, depending on how tight or loose you prefer. I also recommend checking out the size chart. It's a good indicator of what to expect. Best of luck!
Im 5'8 140lbs what size?
Im 5'8 140lbs what size?
You're right in between the small and the medium. I would probably go with the small based on your weight. The jacket may be just a touch short depending on what you're used to.
I am 5'll and about 160 was wondering what...
I am 5'll and about 160 was wondering what size to order
Medium will work for you, walker.
is this jacket more of a slim or loose...
is this jacket more of a slim or loose fit?
Loose fit


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EL SEGUNDO -- Andrew Bynum strained the rotator cuff in his right shoulder during practice but is expected to play Wednesday night against the Clippers. Bynum probably will be able to practice again Tuesday; the injury is considered that minor.
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JD Jorgenson: Time and Place
JD's clay work focuses on three components: time, place and material. Jorgenson's work uses native clay, wood firings, as well as techniques learned during his apprenticeship at The Saint John's Pottery Studio combined with current approaches.
May 27, 2016
- September 16, 2016
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text: Applied Physics: Weight-Lifting "Work" OK, sorry, this may be in the wrong place.... but where would you post something like this? This may be too simple, but I cannot get my mind wrapped around this. I need to lose weight and I want to be able to 'quantify' the calories I burn. If I am bench pressing, and I raise 100 lbs. through a distance of 24 inches, how much 'work' have I done, in terms of calories burned? We can neglect all the variables such as efficiency, speed of movement, work done in 'lowering' the weight, etc. I just want to know what the minimum work (change in potential energy) is, in terms of calories required. My goal is to be able to say, "I want to burn X calories per day. How much weight do I have to move per day (through the 24" distance) to burn at least that many calories?" Thanks in advance for your help.


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Homeowners in Yolo County can get information on reverse mortgages, including an informational packet with a DVD, at a meeting at 11:30 a.m. Thursday, Dec. 6, at Ludy's Main Strett BBQ, 667 Main St. in downtown Woodland.
Linda Darvishian, a reverse mortgage consultant, will speak and answer questions following her presentation. The meeting is open only to homeowners age 62 and older, along with family members and friends.
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Wednesday, December 26, 2012
We had a lovely Christmas. Christmas Eve was the big dinner I hosted and everything went fine and was fun and relaxed and everyone said I did a great job! It felt good! Christmas Day was nice and relaxed and I never left the house :)
The only downside is for some reason I just didn't stop eating! I won't list all the stuff here as it may trigger cravings in others, but almost every time I ate I wasn't even hungry and it was a lot of food. I felt that huge swollen belly uncomfortable feeling. It felt gross and I was really disappointed in myself. But I made the decision to work on exerting control today and eat in moderation AND to get some form of exercise in while the kids are napping.
For the most part today has gone as planned. I had a green smoothie for breakfast, my vitamins, coffee and lots of water. That should help get nutrients in and flush the junk out. Okay, the coffee was just because I was tired LOL. Though it does help with the flushing I suppose. Anyway...At lunch I snacked a bit on some crackers and ham and a couple bites mac n cheese while making the kids lunch - that was not planned. I had made a small dessert size plate of some ham and some green bean casserole for my lunch and decided I definitely would not eat it until after I worked out since I had snacked.
I put the kids down for nap, changed into workout gear and did Zumba on the wii. Yay! I did 45 minutes and put some energy into it and got 96% accuracy and burned over 700 calories though on here it said 511 - either way I'll take it. Then I stretched and by then I was feeling good - that energized feeling along with the warmed up and recently stretched muscles...aaahhh... So then I ate my ham and green beans. But then...I snacked again. Why? had a small piece (like 2 bites) of a 7 layer cookie bar and a piece of cheese coffee cake. Ugh. Why?
Oh well, moving on. I did track it too. I won't be in range for probably another week or so but I'm getting back into my tracking habit and becoming more aware of what I'm eating and amounts, etc. Then I need to plan some healthy meals and really buckle down! :) Also I'm focusing on getting back into a workout routine, so that's good.
At least today is more in control than yesterday and the day before. I boxed up and gave away a lot of goodies too to get them out of the house and I'm going to start throwing stuff away. I will not eat all of it just to get rid of it. I am still eating a some out of a mixture of frugality and pleasure, but there has to be a limit, a line where it's better to throw it in the garbage than put it in me. One or two days of leftovers is good. Plus food safety-wise you can't keep this stuff forever and we have LOTS of leftovers! We could eat off of it for a week or more. Plus as good as it is, I'm going to get hammed out! :)
Overall this holiday season has been great, but I'm so ready for it to be over. 2012 was a great year as well. I grew and matured a lot (while shrinking my body a bit! lol) so I am pretty excited to see what 2013 holds. More body shrinking for sure LOL. More learning, more giving and receiving love. New friendships. New challenges met and overcome. More confidence and strength. And continued improved health. Bring it on! :)
Hope everyone's December was fabulous. Here's to the new year and all of the joys that come with it!
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Go you! At least you are making steps to develop your healthy lifestyle again. The holidays really screwed me up. I don't think I will be eating my family's cooking next year. It really messed me up and I couldn't seem to get back to it yesterday. Today I am making a better effort and going to the store to load up on the good food again today.
I will be checking in on you from time to time so make sure you stick with it!
p.s. I'm really happy your blogging again. I enjoy your blogs a lot!
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I read the most fabulous quote about making today be the day that counts: "Don't tell yourself that it's OK to do something wrong and make up for it later. Doing it right now will put you in the lead instead of catching up." And it sounds like you are doing that by getting back to the fitness and clearing out the leftovers.
This year I told my room mom to please pass along that I am trying to stay healthy during the holidays and sure enough, she passed it along. I got two boxes of chocolate (instead of the usual 5 or 6 and plates and plates of cookies and treats) and gave them away right away. Phrew!
I can only say that we need to keep plugging away and making sure that the fitness and nutrition smarts become habit. How do you like the Wii Zumba? We don't have a Wii, but an old PS2 and I'm on the fence.....
I hope you have a wonderful day - we keep getting one day further from the holiday goodies, and one day closer to the new year.
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We are all in the same proverbial boat - most of us anyway. Tricky time of year to stay on track. I love that this site helps to keep us accountable. Hang in there and Happy Holidays! Pat
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Keep going!
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Glad you had a good Christmas! Hope the new year treats you well.
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5 Parks near Eureka, California
Arcata, California 6.46 miles NE
Blue Lake, California 13.9 miles NE
Fortuna, California 14.41 miles S
Ferndale, California 16.35 miles SW
Trinidad, California 19.38 miles N
Eureka, California (map) | (707) 442-6652
Sites: 24 | Latest Rate: $20.00 | 2 Reviews
|Clean Restrooms:
|Clean Showers:
Sep 2014 - $20.00
You must be an Elks member to stay here. We stopped here to do some sightseeing around the Redwoods. During our three day stay, there was a thick fog which is pretty typical of this coastal area. This is a very basic campsite with access to the Lodge lounge. We appreciated the full hookups. Each faucet serviced two sites but didn't cause any issue with water pressure. Each site was spacious with easy in and easy out access. The Avenue of the Giants was an easy trip from here as was the town of Eureka with access to all of the usual shops, including Costco. We would stay here again. - The Chouters
Jul 2013 - $20.00
Elks Members Only. Back-in sites only. Very good Digital Cable, Wi Fi available, Verizon OK, Dog Friendly. Construction of larger building ongoing. Loss of some RV sites until completed. Great spot to stay when doing "West Coast Elks Tour". Located in quiet neighborhood. Very friendly lodge. Will stop again. Eureka Golf Course approx. 1/2 mile away. - silverado
Eureka, California (map) | (707) 822-4243
Sites: 137 | Latest Rate: $52.00 | 39 Reviews
|Clean Restrooms:
|Clean Showers:
Jul 2015 - $52.00
WiFi was showing but could not connect so would probably not stay again because of that fact. All else was satisfactory, good or very good. - LottaTidbits
Jul 2015 - $48.00
No trees or divisions between sites that are gravel and mostly level. The amenities are good for families, and they are pet friendly. East of the 101, it was tough to find, because the signage is tiny, and the turn tells you "KOA road" but puts you in an area of industrial shops--the entrance is behind these places. My GPS kept telling me I had "arrived" but there was only a tiny KOA sign. Found it though. If you're tired from a long day, you might make note of this.
The campground is for sale (July 2015), and I don't think it is a joyful thing for the employees. They were pleasantly professional, yet I felt the "leaving" mentality in dealing with the people.
Great for an overnight or a base camp for visiting the area--in summer call ahead for a reservation. - Elin
Jul 2015 - $52.00
Poorly maintained park is perhaps a reflection of owners desire to sell. Electrical service is inadequate: low voltage at both 30 & 50 amps. WiFi is slow to non-existent. Sites are not level. Staff is friendly and accommodating. Hopefully the next owners will invest in upgrades needed in this park. - Roger H.
Eureka, California (map) | (707) 442-2284
Sites: 53 | Latest Rate: $29.00 | 3 Reviews
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Jan 2014 - $29.00
This marina is on a spit of land sticking out into the sea and is full of longer term and permanent residents. Many obviously fishermen type: both anglers and workers on big boats with families and kids. The owners are nice enough and friendly. There are seafood restaurants nearby and some low sand dunes within an easy walk. There is no WiFi, no cable, no washroom facilities, no showers, the lots are small and narrow, and all back in. The place is essentially a parking lot. I liked it because it felt "real" and not tourist. Fine for an overnight stop if you are self sufficient, and cheaper than most places in the area. We would have stayed for a week but we need WIFI. We would stay again. - Judy Birchland
Nov 2012 - $25.00
This is an older site, with mostly permanent rigs it appears, but an OK place for one night before traveling on. Full hookup for $25 in California seems really cheap from what I've seen. No discounts. The manager was really helpful and friendly, in fact hung around to register me and help me park after I called near their closing time. No restrooms, so you must be equipped with your own. - Littlebigrv
Sep 2010 - $25.00
Parking lot in a shabby part of town, but seems safe. Very quiet, next to the ocean, wide spaces. Cable TV only available to long-term campers (which most were). Showers were closed for the season. Affordable place for an overnight stay. - Keeping up with the Joneses
Eureka, California (map) | (707) 445-3037
Sites: 52 | Latest Rate: $18.00 | 32 Reviews
|Clean Restrooms:
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Sep 2015 - $18.00
Their information states no campers older then 2005, but I'm sure several of the ones there were substantially older than that. Most of the people live there full time. Sites are very close together and there is only one electrical box for two sites with only one 30 and one 50 amp plug in so check before setting up to make sure what you need isn't being used already. The camp host was never around. I wouldn't stay there again. - Lynn-Donny
May 2015 - $30.00
The campground is not picturesque. Basically a gravel area off one of the main driveways into the fairgrounds, so it is noisy. We were there on a race weekend, so it was exceptionally noisy. There are a few long term RV's (trailers) in the park that are in fair condition. There is supposedly an age limit on the RV's staying here; it obviously is not enforced. The CG manager lives in the CG with several kids who run amuck. The campsite has 20/30/50 electric, gravel, no picnic table or fire ring. Fairly level. Spaces are tight, but only when fully occupied. No privacy, no shade. The water is good quality at about 60 psi. No cable and only basic OTA. Internet is free, but very slow, about 300 kbps. No laundry. The showers are old and in need of remodel, but clean. The staff in the office are OK, but do not patrol the CG or enforce rules. The CG is located in Eureka, so everything is close. There is a Fire Station across the street with occasional sirens. This is not a destination CG. Short stays are tolerable, but longer would be stressful. Will only stay here again if we need to be in the area. - Wiyndog
Jan 2015 - $18.00
If in the Eureka area, we would stay here again at the Passport America rate. The sites are gravel with a bit of grass, all easy back-ins. Traffic noise is minimal. Good location for Eureka city activities. Pleasant and efficient campground host. Wifi was excellent, Verizon phones worked fine, with antenna TV we got PBS, major networks except NBC, plus a few others. Don't think our sat TV would have worked because of close trees (big) to the south. - rncordy
Eureka, California (map) | (707) 443-2222
Sites: 55 | Latest Rate: $41.00 | 49 Reviews
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Jul 2015 - $41.00
Giving this park 1 star due to manager lies. We needed a spot for the night while on our way down south. We called to see if they have space and the guy said he has "ONE SPOT LEFT" and if we want it, he needs a credit card over the phone. When we got there, we realized that we got scammed!! there were many empty spots. The guy lies to you just to get you in! What a great start.The rate as published is $38. Good Sam discount is 10% but we got charged $41.33. When we questioned him he said that there is 12% tax. I am not a mathematician but come on really?? you're going to cheat people like that?The place is creepy, noisy, and tight if you drive anything over 35ft. Do yourself a favor and stop somewhere else.... - Presidio40
Jul 2015 - $45.00
At first we were just impressed by the neat and clean park. We were staying there and supposed to check out on the 4th of July. We found out that our next destination was going to be very difficult to get into with our 45' motorhome. The park manager set us up alongside of the office with cones all around for a day, until he found another site he could put us in. He was exceptional. The hospitality has been great. We would definitely come back. - Pickyparker
Jul 2015 - $44.00
There was a minimum of two nights or we would have stayed only one. The park is more like a nice parking lot with long drive-through spaces that can accommodate long rigs. However, the sewer hookup is very inconvenient. You either have to have a very long hose or wait until you're ready to leave to dump and pull forward.
The spaces are very narrow and have grass in between. The sprinklers come on so the grass is always wet making it hard not to track grass clippings in your RV. Our site was covered in bird droppings, that wasn't pleasant either.
The park is easily accessed from Hwy 101. Our spot was back from the road. It was cold so our windows weren't open and we weren't bothered by the road noise. The park manager, was very nice and helpful. He can give you good recommendations for places to eat/visit.
If you walk to the town of Eureka, which we did, you will pass a lot of homeless camping in the area. It is a very depressed town. While we were not bothered, I would not have felt comfortable walking to town by myself or at night. - Ree Klein


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Bedtime Brownies Recipe
4.5 1
Donna Brockett of Kingfisher, Oklahoma sends her recipe for brownies that are so super-chewy, fudgy and delicious, you won't believe they're light!
- 1 teaspoon instant espresso or other coffee granules
- 1 teaspoon boiling water
- 1 egg
- 3/4 cup sugar
- 1/4 cup dark corn syrup
- 3 tablespoons butter, melted
- 1-1/2 teaspoons vanilla extract
- 3/4 cup all-purpose flour
- 1/2 cup dark baking cocoa
- 1/2 teaspoon baking powder
- 1/4 teaspoon salt
- 1 teaspoon confectioners' sugar
- In a small bowl, dissolve espresso granules in boiling water. Stir in the egg, sugar, corn syrup, butter and vanilla until blended. Combine the flour, cocoa, baking powder and salt; stir into sugar mixture until blended.
- Transfer to an 8-in. square baking dish coated with cooking spray. Bake at 350° for 20-25 minutes or until a toothpick inserted near the center comes out clean and brownies begin to pull away from sides of dish. Cool on a wire rack.
- Sprinkle with confectioners' sugar. Cut into squares. Yield: 9 brownies.
Originally published as Bedtime Brownies in Light & Tasty February/March 2008, p53
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ABSTRACT: Shank2 is a PDZ-based adaptor that has been suggested to regulate membrane transporting proteins in the brain and epithelial tissues. Here, we report that Shank2-mutant (Shank2-/-) mice exhibit aberrant fluid and ion transport in the intestine. Molecular characterization using epithelial tissues from Shank2+/+ and Shank2-/- mice revealed that a long spliceoform of Shank2 (Shank2E) is predominantly expressed in the pancreatic, renal, and intestinal epithelia. In functional assays, deletion of Shank2 increased the cystic fibrosis transmembrane conductance regulator (CFTR)-dependent short-circuit currents by 84% (P < 0.05) and 101% (P < 0.05) in the mouse colon and rectum, respectively. Disruption of the CFTR-Shank2-phosphodiesterase 4D protein complex appeared to be mostly responsible for the changes in the CFTR activities. Notably, Shank2 deletion profoundly increased cholera toxin-induced fluid accumulation in the mouse intestine (~90%, P < 0.01). Analyses with chemical inhibitors confirmed that the hyperactivation of CFTR channel function is responsible for the increased response to cholera toxin. These results suggest that Shank2 is a key molecule that participates in epithelial homeostasis, in particular to prevent overt secretory responses caused by epithelial pathogens.
Article: Na+/H+ Exchanger Regulatory Factor 3 Is Critical for Multidrug Resistance Protein 4-Mediated Drug Efflux in the Kidney[Show abstract] [Hide abstract]
ABSTRACT: Na(+)/H(+) exchanger regulatory factor 3 (NHERF3) is a PSD-95/discs large/ZO-1 (PDZ)-based adaptor protein that regulates several membrane-transporting proteins in epithelia. However, the in vivo physiologic role of NHERF3 in transepithelial transport remains poorly understood. Multidrug resistance protein 4 (MRP4) is an ATP binding cassette transporter that mediates the efflux of organic molecules, such as nucleoside analogs, in the gastrointestinal and renal epithelia. Here, we report that Nherf3 knockout (Nherf3(-/-)) mice exhibit profound reductions in Mrp4 expression and Mrp4-mediated drug transport in the kidney. A search for the binding partners of the COOH-terminal PDZ binding motif of MRP4 among several epithelial PDZ proteins indicated that MRP4 associated most strongly with NHERF3. When expressed in HEK293 cells, NHERF3 increased membrane expression of MRP4 by reducing internalization of cell surface MRP4 and consequently, augmented MRP4-mediated efflux of adefovir, a nucleoside-based antiviral agent and well known substrate of MRP4. Examination of wild-type and Nherf3(-/-) mice revealed that Nherf3 is most abundantly expressed in the kidney and has a prominent role in modulating Mrp4 levels. Deletion of Nherf3 in mice caused a profound reduction in Mrp4 expression at the apical membrane of renal proximal tubules and evoked a significant increase in the plasma and kidney concentrations of adefovir, with a corresponding decrease in the systemic clearance of this drug. These results suggest that NHERF3 is a key regulator of organic transport in the kidney, particularly MRP4-mediated clearance of drug molecules.
- [Show abstract] [Hide abstract]
ABSTRACT: BACKGROUND: The atopic diseases, which are the most common chronic diseases of childhood, are complex genetic diseases that involve the contribution of multiple genetic factors to disease pathophysiology. Chitotriosidase is involved in innate immunity, but the association of chitotriosidase with allergic diseases remains unclear. OBJECTIVE: To examine the contribution of genetic variation of the chitotriosidase-encoding gene CHIT1 to atopic phenotypes in a Korean cohort of children. METHODS: We identified CHIT1 variations in a Korean population and conducted association analyses using 295 atopic and 242 nonatopic children. An independent replication study was performed using DNA samples from 148 atopic and 243 nonatopic children. All children were unrelated. We performed Western blot analysis in each genotype in vitro to see whether the CHIT1 A442G variation affects the final protein expression levels. RESULTS: In the case-control association analysis, atopy was significantly associated with a single A442G (rs1065761) polymorphism in CHIT1 (odds ratio = 1.32, P = .01). Children with the c.442G risk allele had significantly higher blood eosinophils (P = .001), total serum IgE (P = .007), and eosinophil cationic protein (P = .02) levels. The results of the replication stage analysis confirmed a significant association between the A442G polymorphism and childhood atopy. The joint analysis of the exploratory and replication studies displayed a stronger significant association. The relative protein expression levels of chitotriosidase were significantly higher in both cell lysate and media with the G transfection compared with the wild type. CONCLUSION: These results indicate that the nonsynonymous A442G polymorphism in CHIT1 is associated with risk of atopy.
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ABSTRACT: SLC26A3 functions as a chloride/bicarbonate anion exchanger expressed in the secretory epithelial cells in the intestine, pancreas, and salivary glands. SLC26A3 has a C-terminal class I PDZ binding motif that assembles regulatory factors or other transporters by anchoring to various PDZ scaffold proteins. NHERF4 is an epithelial-enriched PDZ domain scaffold protein that has attracted attention because of its enriched tissue expression in the intestine and kidney. In this study, we identified SLC26A3 as a novel binding transporter of NHERF4. We investigated the functional role of NHERF4 in the regulation of SLC26A3 by using integrated biochemical and physiological approaches. A direct protein-protein interaction was identified between the PDZ-binding motif of SLC26A3 and the third PDZ domain of NHERF4. Interaction with NHERF4 decreased the level of SLC26A3 expression on the plasma membrane, which led to reduced SLC26A3 anion exchange activity. Notably, interaction with NHERF4 induced rapid internalisation of SLC26A3 from the plasma membrane. The SLC26A3-NHERF4 interaction was modulated by phosphorylation; serine 329 of NHERF4-PDZ3 played a critical role in modulating binding selectivity. Our findings suggest that NHERF4 is a novel modulator of luminal fluidity in the intestine by adjusting SLC26A3 expression and activity through a phosphorylation-dependent mechanism.
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Yonsei University
Sŏul, Seoul, South Korea
- College of Medicine
Ewha Womans University
Sŏul, Seoul, South Korea
- • College of Pharmacy
- • Center for Cell Signaling and Drug Discovery Research


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text:
|Reviews for Conversing the Dragon
| Guest chapter 1 . 1/26
| SailorIllusions chapter 1 . 7/20/2015
I gotta say, I went on a binge-read with this. It took a long time, but it was definitely worth it. It was fantastic, how their relationship slowly evolved. I love that you took the time to do it because it made it so much more realistic. Hitsugaya's dark and possessive side was explained quite well and allowed you to feel that it didn't just come out of the blue.
This is probably one of my favorites of all time for this ship!
| Prince Yin chapter 23 . 6/2/2015
I actually really like this story, and you sort of made me join the hitsuruki army? I never would've imagined this pairing in the beginning, but after reading this, wow.
| Guest chapter 15 . 4/14/2015
I think you're over dramatising the subject of Hinamori and even portraying her in an extremely negative light. I'm no fan of her's but I also think that you're allowing your opinions to cloud your writing. A lot. Everything else is perfect-ish though. You still need improvement but doesn't everybody?
Sorry. I just had to get this out of my system. The way you were writing Hinamori...
Also, she was being-dare I say it? -bashed. And she was very OOC. Also, you are kinda, sorta making Rukia a...Mary Sue...in a way...Gah! I can't believe I'm calling one of my favorite female characters of all time a Mary Sue! I feel so conflicted...
If this review offends you, I would like to inform you that was not my intention. I'm simply trying to semi-peacefully confront you...
P.S I don't have an account so...
| Guest chapter 23 . 12/6/2014
You are the genius of making odd and unpopular pairs.
| Chibi Shiro chapter 1 . 11/28/2014
Awwwwwwwww! Our little Shiro-chan has grown up and do "the thing" to our lovely Ruki-chan
| Angel Fantasy chapter 1 . 9/28/2014
This story has so much potential that I find myself hooked. A rare feat, considering that Rukia is neither my favorite nor my most despised Bleach character. Now, I am curious as to how this talking relationship between the two Ice wielders will develop. Hopefully Matsumoto will be able to overcome her fear of her beloved Taichou somewhere inside the story!
| hitsuruki chapter 2 . 7/19/2014
poor my rukia
| rukiruki chapter 1 . 7/19/2014
so cute
please make more hitsuruki
| FanficChick901 chapter 13 . 6/24/2014
Cool chapter! More than a kiss next time, plz!
| FanficChick901 chapter 11 . 6/24/2014
Good chapter! He thinks he loves her! P.S. I like it when guys are jealous in stories too! :))
| FanficChick901 chapter 7 . 6/23/2014
This was a good chapter! Their relationship is progressing! I like that :))
| FanficChick901 chapter 6 . 6/23/2014
Good Chapter! Can't believe Rukia didn't achieve bankai, though. The romance is still building UP! :))
| FanficChick901 chapter 4 . 6/23/2014
Good Chapter! Rukia's really naive... I LOVE IT!
| FanficChick901 chapter 3 . 6/23/2014
The romance is building up! Good chapter! :)


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This product hasn't received any reviews yet. Be the first to review this product!


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the two medallions compared with ten cents by AngeniaCWatch
©2012-2016 AngeniaC
the two medallions compared with ten cents
I know both the songs that are taking place here
Those are gorgeous~
They are both amazing!!!!!!!!!!
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Mola mazo, muy bueno!!
OMG!!! I'm speechless!!!
Complimenti...sono bellissime
Astonishing ! I love them !
These are so cool! Muy Bonita!
Waw °-°
Euros ! :3
Euros ! :3
absolutely awesome!


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EGM's August Issue Checks Out Killzone 2
Our August issue contains a big preview of this PS3 shooter.
Before jumping into the new game, we've got a round-up of the story and characters from the previous two Killzone titles, so you don't need to be left behind if you never played them. In addition to discussing the general shooting gameplay, we also had the first chance to play with vehicular combat via a powerful tank that will be at the player's disposal for certain sections of the game. And that's not all for weaponry -- we also compare the guns and equipment of the ISA (i.e. the good guys) and the Helghast (i.e. the bad guys).
On top of our hands-on time with the game, we also interview Guerilla Games and get their thoughts on the original controversial trailer, the delay to 2009, and how they got stuck with the "Halo-killer" tag that they feel doesn't really stick. Guerilla managing director Hermen Hulst tell us, "Killzone's always been a very different beast than Halo. So none of us really wanted to make that comparison." Nevertheless, they're hoping to polish their second attempt at a major FPS release in this franchise to the point where it can compete with the big boys of the genre, including Call of Duty 4. Will they pull it off? Check out our preview and decide for yourself.
The August issue of EGM should be hitting subscribers in the coming days, and it will be available at newsstands soon.
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Comments (46)
@hydraulicsPosted: Jun 25, 2008 12:00AM PST by Thanos_of_MW
Hard to believe...not. If you check my profile's pictures you'll see :P I have more games on 360. Only 3 for PS3 (4 with the ordered MGS4) I'm glad the situation is starting to get better for PS3. 360 gets used way more, so far. If a game is multiplatform, I usually buy the 360 version. It didn't help that 360 launched first, and games were ported to PS3 (and sucked compared to the 360). Bad reviews don't help sales. Good thing the PS3 exclusives are coming.
hard to believePosted: Jun 25, 2008 12:00AM PST by hydraulics
that ps3's are allegedly not being used and are gather dust... When the only good game for 360 for casual gamers is Halo 3, and i dont even consider it a good game, story sucked, and multiplayer is the most REPETATIVE gametype ever. COD4 rapes H3, straight. This should be awesome, Killlzone 2.
@nasimPosted: Jun 24, 2008 12:00AM PST by Thanos_of_MW
Sorry nasim, but the same could be said of PS3 by a 360 fanboy. In the beginning I was calling it the "Resistance box", and I'm no fanboy. i own both consoles. I'm glad PS3 is getting more exclusives, that way it won't gather dust anymore in my entertainment center. As much as I like my 360 (for the many games), now PS3 is getting the "big guns" out and of course I'll be getting the games, including Killzone. The problem is going to be coming up with money and time to play them all ;)
good gamePosted: Jun 23, 2008 12:00AM PST by mackmittens313
i think killzone two is going to be sweet. the first one was good it was just they tried to cram too much into it so it was very choppy
You're all moronsPosted: Jun 21, 2008 12:00AM PST by -x-TRIPWIRE-x-
One, don't come onto a blog if you didn't even play the game and say it sux if you've never played it. Two, don't take everything off of hearsay. I know alot of people like you that heard Kilzone sucked, went and rented it and was amazed by how really good it was, especially for a rushed project as it was. So, as a Killzone player as I am, don't crush a good game. I admit, it sucks now because the servers are horrible now and they aren't maintained like they're supposed to be but two years ago it was an amazing game, don't forget it was on a PS2. Lower rate hardware than the PS3 and Xbox 360. Killzone 2 is going to be amazing even though you can't admit that now. Just wait and see and please stop being a bunch of morons.....
YeaPosted: Jun 20, 2008 12:00AM PST by loaththemachine
Ive been waiting for a story longer than a paragraph. Killzone was one of my favorit games it got good reveiws it just came out at a bad time and was called a halo killer, also people stop complaining about it having the cover story halo 3 did and gears of war 2 did.
wretchedradiov3Posted: Jun 20, 2008 12:00AM PST by Clinton514
Take a walk to systemwars.com if you want to play that type of cry business. Anyhow, I guess this is why Garnett and Shane couldn't talk about Killzone 2 on 1Up Yours.
Can't Wait...Posted: Jun 20, 2008 12:00AM PST by Aluccard
I rarely play my Ps3 but I can't wait to get my hands on Killzone 2. I guess I was one of the few that thought Killzone 1 was awesome, and far superior to Halo 2 that came out at the same time. Until then, I guess I'll just go back to my 360....
Here's hoping its goodPosted: Jun 20, 2008 12:00AM PST by chaos and mayhem
I'm an xbox 360 guy, with no plans on buying a PS3, even for killzone or metal gear solid 4. Still, I hope that Killzone 2 will be an awesome game, not so much for the well being of the PS3, but to force Microsoft to actually produce some must haves next year. All we have coming up is Gears of War 2 and maybe Too Human. And don't tell me about the multilplatforms because they don't count.
competitionPosted: Jun 20, 2008 12:00AM PST by saudigamer
I don't think there is any competition, at least for me. I didn't like Halo ; all three of them. there're more of a MP shooter. There is no focus on the story. As for COD, the story is great but kinda short. So KZ2 is definately gonna be THE shooter i'm waiting for.
Sony FanboyismPosted: Jun 20, 2008 12:00AM PST by wretchedradiov3
HAHA. I love how Shane is the one writing the article. I bet this will somehow be the best FPS ever in his eyes. He's so far up Sony's ass. Guys, face it....Killzone SUCKED. It was no good. This crap looks like more of the same, except a little nicer looking. And Resistance was a boring, mediocre, geneirc game that only sold well cos it was a launch title and you poor saps had nothing else to buy for your Sony Blu Ray Player. And you STILL DON'T TWO YEARS LATER. Come on, juniors....man up and get PC's and 360's!
It's funny...Posted: Jun 20, 2008 12:00AM PST by duhbeyuh
... I was dead set against subscribing to any magazine but after my sister went out and got me a subscription to EGM 2 yrs ago I wouldn't have it any other way. It's so much easier to have the mag just sent to my mail box then it is to go out every month and hunt down a damn copy of EGM. The point of this you ask? My subscription ran out in June and now I have to re-subscribe, though I think this time it's gonna be for 2 yrs. BTW, these new EGM covers are kicking ass lately! Keep up the good work.
KZ2Posted: Jun 20, 2008 12:00AM PST by Dr_Yassam
formergcfan wrote: "I hope it turns out well". Agreed, I hope so too, and well said. Although I wouldn't include Resistance 2 in the list of games that should have been out already, because Resistance was a launch game, and that was only 19 months ago.
Really nasim?Posted: Jun 19, 2008 12:00AM PST by Dr_Yassam
nasim wrote: "sucks to be an XBOT". Actually nasim, it sucks to be a fanboy of ANY format, and you're clearly a PS3 fanboy. Saying the 360 only has GeOW2 is as ignorant as XBOTs saying the PS3 has no games. Grow up please, there are great games on both consoles, and many great games to come. We don't know how good or bad the exclusives for both will be in future, we have to wait and see, so stop being childish and just enjoy the games you have.
KZ 2Posted: Jun 19, 2008 12:00AM PST by formergcfan
I hope it turns out well. The first game wasn't awful but it did not come close to being a "Halo Killer." This game needs to live up to the hype because frankly outside of MGS 4, PS3 doesn't really have any top notch exclusives right. Ratchet and Clank, Uncharted, Heavenly Sword, Resistance were all good imo, but not what I'd consider to be AAA. Resistance 2, this game, FF XIII, White Knight Chronicles, the full retail verison of GT 5, Tekken 6... These games should have been out yesterday. Before MGS 4 my PS3 was getting used less than the Wii only being turned on for a few games of MLB 08 The Show. There will be great AAA exclusives for this system but they have been way too slow in getting here.
KZ2.....Posted: Jun 19, 2008 12:00AM PST by !Wissy!
It really can't live up to the hype because it is going to get the same attention that Halo 3 got and I don't care what anybody says, Halo 3 id not come anywhere close to what it should have been. As for people talking about SOCOM, SOCOM has always been a niche type game that the masses did not get into but for the people that like SOCOM it is amazing. SOCOM was easily the first addictive online console shooter.
all the biggest games are PS3 exclusivesPosted: Jun 19, 2008 12:00AM PST by nasim
sucks to be an XBOT no games except GEARS2 and multiplat titles MGS4 alone is bigger than x360's entire gaming library not to mention FF13,KZ2,FF13v,Resistance 2,White Knight story KZ2 will tear away all sales records and so would Resistance 2 with 60 player online and 8 player co-op
PS3 Galore!Posted: Jun 19, 2008 12:00AM PST by shadow_bane
Not that I have a problem with the PS3 or EGM, but this issue looks like its going to have a heavy focus on PS3-only games. As an owner of an Xbox 360 and Wii, I only have a slight motivation to buy the issue because of the Star Wars: The Force Unleashed exclusive and the Mercs 2 info. Its not that I have a problem with the PS3, but for only wanting to read two articles and skim through all the PS3 stuff, I wish I didn't have to pay the full price of the 'zine. I like the look of MGS4 and Killzone 2 though, so what the hell, I'll buy it anyway. Heres to EGM! --- P.S. NO DOUBLE POSTING *ahem, Yorudan, ahem*
Don't forget about Resistance....Posted: Jun 19, 2008 12:00AM PST by N8Dogg
Resistance 2 should easily outsell Killzone 2. It's more likey though that Killzone will come out Fall09 a month before COD5. So it's to early to even care. Having never played Killzone I am not to excited, b/c my friends who have say that it was mediocre at best.
YOU anti-ps3 fanboysPosted: Jun 19, 2008 12:00AM PST by Yorudan
are the ones that keep going on the this hype... as far as i know Halo 3 looked like a toon cell-shaded game, did you see that Halo 3 trailer? huh? EXACTLY IT LOOKS NOTHING LIKE THE GAME YOU ASSHOLES. @ least this game looks just as good if not better than that pre-rendered video. suck it up bitchs cuase no matter how long you bash on it, you'll never get to see the light of day of this game
YOU anti-ps3 fanboysPosted: Jun 19, 2008 12:00AM PST by Yorudan
are the ones that keep going on the this hype... as far as i know Halo 3 looked like a toon cell- game, did you see that Halo 3 trailer? huh? EXACTLY IT LOOKS NOTHING LIKE THE GAME YOU ASSHOLES. @ least this game looks just as good if not better than that pre-rendered video. suck it up bitchs cuase no matter how long you bash on it, you'll never get to see the light of day of this game
I noticedPosted: Jun 19, 2008 12:00AM PST by Clinton514
Most of the negative BS is coming from people who haven't even touched either Killzone titles. Great objectivity there guys. :| Anyhow, Let's hope some fresh info regarding multiplayer arrives.
KZ2Posted: Jun 19, 2008 12:00AM PST by Horngreen
This game doesn't stand a chance due to the hype and delays. It will never live down the pre-rendered footage claimed to be gameplay from years back. Might end up being a good game and the PS3 needs some of those but it's just too much under the spyglass to have much of a chance.
feelmyrathps3Posted: Jun 19, 2008 12:00AM PST by papajason5
socom hasnt had a good review since the first game and ghost recon came out. also i highly doubt kojima let sony have a large part in the development of the MGS bc he doesnt like them in his games along with MGS being ported and revamped to the xbox and gamecube. so all sony has left is god of war and i will admit that GoW is a good franchise. Just because a game that has been in development for a while doesnt mean that its gonna be a stellar game. Dark Sector was in development for 5yrs and it was average along with Prey which was in development for 10yrs and it also got average reviews.
Killzone 2Posted: Jun 19, 2008 12:00AM PST by projectrunaway
I am hoping that this game will be better than the first Killzone that was releaesed on PS2 a few years ago. It being delayed to 2009 seems that it wasn't ready yet to be released. Looking forward to the new issue arriving at my house.
galacticPosted: Jun 19, 2008 12:00AM PST by papajason5
yeah i couldnt to change the wording bc my wireless keyboad was going out so i was like fuck it and just posted it. the reason i posted sales figures bc the whole concept of killzone being a halo killer was in sales and it didnt do that at all.
KILLZONE 2...Posted: Jun 19, 2008 12:00AM PST by feelmyrathps3
is really its own class. The fast-paced resistance is more like halo. But really people? Do you actually think a game thats been in production for nearly 5 years and made by SCEA will suck even remotely? Lets look at SCEA's track record: SOCOM, God of War, Gran Turismo, not to mention a large hand in MGS games. Can anyone honestly say any of those games suck? Cause if you can you need to pull the dildo out of your ass and stop bein gay. Killzone 2 will be the shit and pretty much everyone except the faggot Halo lovers know it.
RE:zeecornerPosted: Jun 19, 2008 12:00AM PST by Alucard176
Why do you keep appearing in any Ps3/Sony related news just to dis? Looking forward to what this game has to offer, the first one was ok, so i hope this on is better
Hmm.Posted: Jun 19, 2008 12:00AM PST by Galactic_Barret
When did we start judging how good a game is by how many units its sold? By that logic, Wii Play should be a "Halo-killer". I'm not defending KZ1 or anybody on this site but lets get real: Sales figures don't mean a great (or horrible) game. And PJ, if your gonna call someone out for being incompetent, at least spell correctly. Its "Retarded" there, champ.
Beautiful Disaster?Posted: Jun 19, 2008 12:00AM PST by BlazingAero
After reading 1up's playtime preview for Killzone 2, I'm convinced it's going to be a total deja vu of its predecessor. Predictable, unclever progression points (see a wall that you need to get through, and find a rocket launcher right next to it, screaming at you to use it), and a generic blandness that even amazing graphics can't sweeten. The 1st was very similar: some of the best graphics on PS2, yet bland, boring, busted gameplay. PS3-heads expecting a killer app are almost guaranteed to be disappointed.
VaporwarePosted: Jun 19, 2008 12:00AM PST by Gamecrusher
I've heard about this game for years now and it seems to me that DukeNukem Forever has a better chance of publishing in this century. By the way Killzone was a P O S that sony fanboys had to love because they had nothing else. SOCOM series are the best PS2 shooters around.
CoverPosted: Jun 19, 2008 12:00AM PST by TheBarryman
Gotta give props to Milky. Other than the Splatterhouse issue, nearly every cover has looked fantastic since he took over as EIC.
killzome 1Posted: Jun 19, 2008 12:00AM PST by papajason5
naked_eye is the biggest fucking retarted on this whole site. in no way is killzone a halo killer. how many copies did h3 sell its first week? 3.3 million. H1 sold 1.4 its first week, H2 sold 2.8 mill its first week.those figures are just the first weeks sales. all together the halo franchise is the best selling console FPS franchise. i bought killzone 1 for 14.99 used at gamestop and it wasnt even worth that. the game play was garbage, the sniper rifle had the worst auto-aim ever and you are a bioengineered super soldier that cant jump over a 6 inch fence.
And on the story side of thingsPosted: Jun 19, 2008 12:00AM PST by Video_Gamer_Boy
The team behind this game needs to take a look at COD4, Bioshock, GTAIV, Half-Life, MGS4 etc. I feel that a shooter these days needs to be more than just that, a shooter. It needs to have a compelling story told in the right way. And seriously, they better be looking at COD4 and Halo 3 for multiplayer. Seriously.
I wouldn't call killzone to a killer appPosted: Jun 19, 2008 12:00AM PST by Orochi_Sasaki
Killzone 2 sure has a good amount of money and hype, but the first killzone had very little hype and was well polished and had good AI and sound for the time it came out..... still have memories of the grenade launcher's *flump*, but I don't think I would call killzone a killer app I would give that to MGS4, Uncharted, UT3, RE5, and resistance...
Certianly needs to prove itselfPosted: Jun 19, 2008 12:00AM PST by Video_Gamer_Boy
The first game wasn't great and by no means a Halo. It had some great ideas and gameplay mechanics but they just didn't come together properly. The team needs to take a look at what shooters like Halo 1,2 & 3 and COD4 have done and take note. I'm hopful but also realistic.
A lot to live up to...Posted: Jun 19, 2008 12:00AM PST by DarthBasileus
I wouldn't exactly say that the first Killzone rocked people's worlds. The premise was interesting and the game had its moments. But for the most part it was a broken mess technically. If KZ2 fails to deliver even a solid single player experience then I think this franchise will follow The Getaway into SCEE franchise oblivion.
I hope so?Posted: Jun 19, 2008 12:00AM PST by scareglow28
This game looks like none other,I just want it to be a good shooter.I never ever thought of it as a Halo killer.


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Best Actress in a Drama (2004)
Patty Mintz Figel, Three Tall Women, Germinal Stage Denver
In Three Tall Women, Patty Mintz Figel played a very old woman whose mind and body deteriorated in front of us. The woman was angry, paranoid, agitated, incontinent, ungrateful and hell to take care of. She rambled about the past. She was a racist, though she barely understood her own racist comments or the revulsion they aroused in others. Figel held nothing back as she portrayed this wretched soul sorting through her own ruined life. She whined and grumbled; she shook with palsy. Later, Figel played the same woman at a younger age, more poised but not a whit more likeable. It was a performance that took real courage.
More Arts & Entertainment Awards
Best Dadaist Bathroom GraffitiGabor's
Best Early-Morning Happy HourZephyr Lounge
Best Free EntertainmentPeople-watching on the 16th Street Mall while we still can
Best Radioactive PhilanthropistNuclia Waste


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Joe Galloway, the dean of the Pentagon press corps, on Friday offered up a stark assessment of the Bush Administration in the McClatchy newspapers. "Why is it that the Bush administration, in its dying throes, looks remarkably more like an organized crime ring than one of the arms of the American government? A poorly organized and run crime ring, truly, but a crime ring nonetheless."
Does anyone doubt that Karl Rove personally drew up the list of those prosecutors who were to be executed because they did not enthusiastically go after people who were likely to vote for the Democrats in any election?
The good attorney general should be fired if he didn't know where that list came from and he should also be fired if he did know and denied it under oath before Congress. It was his department, the one that is supposedly dedicated to upholding the laws of our nation fairly and with an even hand, and he damned well should have known and damned well should have told the simple truth.
Where is it written in either the federal statutes or the Constitution of the United States that our laws against criminal acts apply to everyone but nice, meek, small-statured Republican political operatives who have a wonderful wife and children? Our prisons are full of nice, meek white-collar criminals who cheated a bit on their taxes or back-dated their bountiful option awards or raped and looted the coffers of corporations and beggared the poor fools who trusted them and bought stock in their criminal enterprises.
Galloway's charges are right on target. Look at how the Bush Administration has reacted to the steadily unfolding scandal that is strangling the nation's reputation for justice – from the lies and deceptions about the cashiering of U.S. attorneys, the threats and intimidation directed at the fired U.S. attorneys to get them to keep quiet, the stonewalling and destruction of evidence that ties the White House to prosecutorial manipulations, to the pardoning of Libby, to the gross overreaching that occurred in a courtroom in Montgomery – even as evidence of Rovian schemes is exploding into newspaper headlines around the country. This conduct is not the way that justice officers behave. It is exactly the way an organized crime kingpin would behave.
And let's keep in focus the fact that the man Bush openly referred to with a mob nickname and who is openly dubbed the consigliere in newspapers around the world, Alberto Gonzales, continues to sit as the nation's senior law-enforcement officer and to use the powers of his office to obstruct a proper criminal investigation. The only proper reaction to this reprehensible misconduct is the one Galloway shows: outrage.
More from Scott Horton:
Context, No Comment — August 28, 2015, 12:16 pm
In five easy lessons
From the April 2015 issue
Six Questions — October 18, 2014, 8:00 pm
Nathaniel Raymond on CIA interrogation techniques.
Estimated percentage of New Hampshire's bat population that died in 2010:
New Hampshire Fish and Game Department (Concord, N.H.)
A horticulturalist in Florida announced a new low-carb potato.
In Peru, a 51-year-old activist became the first former sex worker to run for the national legislature. "I'm going to put order," she said, "in that big brothel which is Congress."
Subscribe to the Weekly Review newsletter. Don't worry, we won't sell your email address!
"Civilization masks us with a screen, from ourselves and from one another, with thin depth of unreality. We habitually live — do we not? — in a world self-created, half established, of false values arbitrarily upheld, largely inspired by misconception, misapprehension, wrong perspective, and defective proportion, misapplication."


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2016 Best Companies for Leaders Survey Now Open
GrowthPlay (formerly Chally Group) and Chief Executive are pleased to announce the launch of the 2016 Best Companies for Leaders research. Your participation is key to making this research a comprehensive assessment of the current status of global leader development.
To take the survey, please read these instructions carefully and then click on the appropriate button below.
- You will not be timed, so take as long as you like.
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- The information you provide will be treated as strictly confidential.
All survey participants will receive a copy of the 2016 Global Leadership Research executive summary.
Thank you for your participation.


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Home » Clinical Trials » Search Clinical Trials
Therapeutic Areas: Immunology | Genetic Disease
A listing of Hereditary Angioedema medical research trials actively recruiting patient volunteers. Click on the closest city to find more detailed information on a research study in your area.
Show Filter
Birmingham Alabama 35209
Patients are needed to participate in a clinical research study evaluating BCX4161 and Placebo for the treatment of Hereditary Angioedema or HAE
Scottsdale Arizona 85251
Granada Hills California 91344
Los Angeles California 90027
Patients are needed to participate in a clinical research study of icatibant to evaluate Hereditary Angioedema
San Diego California 92112
Walnut Creek California 94598
Colorado Springs Colorado 80907
A clinical trial to evaluate treatments using CINRYZE for patients with Hereditary Angioedema
University of South Florida - Asthma, Allergy & Immunology Clincal Research Unit
Tampa Florida 33613
A Phase 1b, Double-Blind, Multiple Ascending Dose Study to Assess Safety, Tolerability and Pharmacokinetics of DX-2930 in Hereditary Angioedema Subjects
University of South Florida- Asthma, Allergy, and Immunology Clinical
Tampa Florida 33613
A Phase 2 Multicenter, Randomized, Double-Blind, Placebo-Controlled, 3-Period Crossover Study to Evaluate the Efficacy and Safety of Recombinant Human C1 Inhibitor in the Prophylaxis of Angioedema Attacks in Patients With Hereditary Angioedema (HAE)
View More ▼
Tampa Florida 33613
A clinical trial seeking patients for a research study for the treatment of Hereditary Angioedema
Shreveport Louisiana 71106
Chevy Chase Maryland 20815
Boston Massachusetts 02114
Boston Massachusetts 02115
Plymouth Minnesota 55446
St. Louis Missouri 63141
Las Vegas Nevada 89106
Winthrop University Hospital Clinical Trials Center
Mineola New York 11501
HAE - Patients diagnosed with Acute Hereditary Angioedema
Mineola New York 11501
A clinical trial to evaluate treatments using Ecallantide subcutaneous dosing for patients with Hereditary Angioedema Types I and II
New York New York 10029
Charlotte North Carolina 28277
Cincinnati Ohio 45267
Cincinnati Ohio 45231
Toledo Ohio 43617
Oklahoma City Oklahoma 73131
Tulsa Oklahoma 74133
Eugene Oregon 97401
Lake Oswego Oregon 97035
Hershey Pennsylvania 17033
Pittsburgh Pennsylvania 15241
Dallas Texas 75231
Galveston Texas 77555
Fairfax Virginia 63141
Spokane Washington 99204
Tacoma Washington 98405
New South Wales 2560
Patients are needed to participate in a clinical research study for the treatment of Angioedemas, Hereditary
Graz 8036
Copyright © 1995-2016 CenterWatch.


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RE: [HeroQuest-RPG] Books arrived! Yay!
Expand Messages
- Ha you are lucky! Mine was despatched from the US and while i am still hoping for a pre-Christmas delivery it's not looking likely now :(
To: email@example.com
From: green27@...
Date: Sun, 18 Dec 2011 19:24:21 +0000
Subject: [HeroQuest-RPG] Books arrived! Yay!
My books arrived about an hour ago: HQ2, and both Sartar books! Sunday delivery! :-)
(Haven't seen that in a while - the posties must be working overtime to clear the Christmas rush!)
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* updated 10/14 to reflect update in prices
Denny's, better known for its breakfast grub, is jumping into the premium burger business.
The family-dining chain has scrapped its old, heavily seasoned diner burger for a much-improved hand-pressed burger aimed at fast-food diners. The "Better Burgers"� come in five varieties, including a Western burger that contains similar ingredients as those found in Carl's Jr.'s famous Western Bacon Cheeseburger.
Other varieties include Double Cheeseburger (top photo), a Classic Cheeseburger, Mushroom Swiss burger, Bacon Cheddar burger. Denny's said the new burgers are thicker, juicier and contain more appealing ingredients, such as thicker cheese and shredded lettuce. (see chart comparison below)
The burgers range in price from $7.49 to $9.29. But to tempt diners to try the Better Burger now, Denny's is offering the cheese burger with fries and a drink for $6.99 for a limited time only. (*updated 10/14)
Denny's is also emphasizing the portability of the burger meal, which can be ordered as takeout in the chain's new-improved "dome" containers.
Denny's said it wanted to improve its burger offering to take advantage of a national trend. Research shows that burger chains are seeing some of the biggest sales gains among the sluggish restaurant industry.
U.S. sales in the limited-service hamburger industry grew 4.1 percent in 2008 to $64 billion, according to Technomic, a restaurant industry market research firm. The increase beat the overall growth in the entire limited-service industry, which includes fast-food and fast-casual chains.
Denny's said additional research shows that 21 percent of consumers claim they are eating more burgers.� So improving on its No. 2 selling menu item made sense.
"Burgers are a force to be reckoned with," Chief executive Nelson Marchioli said in a statement.
Tell us: Will you give Denny's new burger a try?
To view a chart, comparing Denny's old burger vs. the Better Burger, click on the image below:
*10/14 Correction: The story was updated to correct the prices for the burgers. When the report first published, Denny's failed to say that the $6.99 combo price was valid for the cheeseburger only. The chain did not provide prices for the other burger varieties until requested by Ocregister.com. My apologies for any confusement this might have caused.
Related stories:
[rssfeedme cat="fastfood" feedpath="/tag/premium-burgers/" max="10"]


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Hello cute weirdo ♥ Do you like Tim Burton's stuff, like Beetlejuice? I made a cute set as Lydia Deetz and had a looot of fun doing it, please tell me if you like it ;) Oh and if you love dark and... (read more)ImpLuna SJHphotography
Thanks for wanting my friendship, SJHphotography!! >^+^<TygerGreenleaf SJHphotography
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"Bare" room
New set by SkullyCaliber & SJHphotography
A Shadow of LEAHDEBENE
New set by Leahdebene & SJHphotography
Introducing LEAHDEBENE
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Ginger Kewl - Art of B/W
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Good Morning, Thanks for the look up. I had a great time Saturday and I hope you get lots of business from all the hard work you did.GingerKewl SJHphotography
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Looking to shoot sets in the Detroit Area...
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Hey! :) we have to shoot again soon!ELane1111 SJHphotography
Nice sets...look good.RayvenNevermoore SJHphotography
Come on SNOW, I want to do a Snow Themed Shoot!


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Mon, 09 November 2009 at 2:44 am
Ellen Pompeo: Clementine Cute
Ellen Pompeo picks up groceries for husband Chris Ivery and daughter Stella Luna at Whole Foods supermarket in West Hollywood on Sunday (November 8).
The Grey's Anatomy actress, who turns the big 4-0 on Tuesday, picked up a bunch of fresh fruits and vegetables including a box of clementines.
Let's hope Mr. Ivery has some big, exciting plans for his missus this week!
15+ pictures inside of clementine cutie Ellen Pompeo…
Like Just Jared on Facebook
Photos: Fame Pictures, Flynetonline Posted to: Ellen Pompeo


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3. Ralfo1:14 PM GMT on January 25, 2013
|THANK YOU ALL FOR YOUR LOVELY COMMENTS AND RATINGS! AND ! THANK YOU APPROVERS FOR THIS AC> I REALLY APPRECIATE THIS! It is very hard to compete today with so many people here with so many Fantastic Photos being entered! I must also tell you how wonderful it is to see you all are doing a LOVELY job being fair in your selections. It is not easy, AND! THANK YOU FOR ALL THE TIME AND EFFORT YOU ALL PUT INTO OUR PHOTO CLUB! Ralf.
Action: Quote | Ignore User
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It's putting things a bit mildly to say, the the New York Post puts it, that "Goldman Sachs is raising eyebrows" with its disclosure that it has amassed a 7 percent stake in Ion Media Networks. Citadel and General Electric's NBC have partnered to target Ion for a buyout, and Goldman is advising NBC on the transaction. Information about potential buyout bids, of course, is not supposed to flow from the investment banking advising side to the proprietary trading side but the close timing of Goldman's Ion acquisition and NBC-Citadel's bid at least looks a bit dodgey.
So is Goldman leaking to Goldman, or is this just an inconvenient appearance of impropriety?
"It's really a matter of how far up the decisions go," one investment banking insider familiar with Goldman Sachs internal controls tells DealBreaker. "If the investment banking advice is coming from far enough down on the chain and the decision to pick up a big stake in Ion came from far enough down, it's probably just a coincidence. But the higher up you go, the narrower things get, and the harder it is for information not to get passed around."
There is, for instance, no "Chinese wall" bi-furcating Lloyd Blankfein's brain.
Goldman's Odd Moves [New York Post]


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You love your butter: now it's time to show it just how much, with dishes and tools that keep it pretty.
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Easy Philly Cheesesteaks Recipe
5 5
Since we live in a rural area where there really aren't any restaurants to speak of, I thought it would be fun to come up with my take on this classic sandwich at home. So effortless and delicious, grab a bottle of steak sauce to top them off for an extra bolt of flavor. —Lenette A. Bennett, Como, Colorado
- 2 medium onions, halved and sliced
- 2 medium sweet red or green peppers, halved and sliced
- 1 beef top sirloin steak (1-1/2 pounds), cut into thin strips
- 1 envelope onion soup mix
- 1 can (14-1/2 ounces) reduced-sodium beef broth
- 6 hoagie buns, split
- 12 slices provolone cheese, halved
- Pickled hot cherry peppers, optional
- Place onions and red peppers in a 4- or 5-qt. slow cooker. Add beef, soup mix and broth. Cook, covered, on low 6-8 hours or until meat is tender.
- Arrange buns on a baking sheet, cut side up. Using tongs, place meat mixture on bun bottoms; top with cheese.
- Broil 2-3 in. from heat 30-60 seconds or until cheese is melted and bun tops are toasted. If desired, serve with cherry peppers. Yield: 6 servings.
Originally published as Easy Philly Cheesesteaks in Simple & Delicious August/September 2013, p48
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Here's a reason to cheer: This past week, the U.S. Department of Education reported that a record number of American teenagers are graduating high school on time. Full story »
South Haven High School is holding a groundbreaking ceremony Dec. 1 outside the front office of the school. Full story »
It was 10 years ago this week Janice Brown unveiled The Kalamazoo Promise -- a program that has transformed Kalamazoo Public Schools, changed the lives of thousands of individuals and launched a national movement on college access and affordability. Full story »
On the night of Nov. 10, 2005, then-Kalamazoo Public Schools Superintendent Janice Brown announced the creation of a new scholarship program, The Kalamazoo Promise. Full story »
Ten years after the unveiling of The Kalamazoo Promise, Kalamazoo Public Schools has improved on every major indicator -- from enrollment to test scores to graduation rates, says KPS Superintendent Michael Rice. Full story »
Members of the Galeburg-Augusta school bond committee will be meeting Monday to figure out where to go from here after the defeat of a $14 million bond proposal on the Nov. 3 ballot. Full story »
Voters in Portage Public Schools approved $144 million in bonds that will fund building two new middle schools, two new athletic stadiums and a major renovation of the third middle school, among other projects. Full story »
About 62 percent of Michigan public school students in the Class of 2014 went to college within six months of graduating high school, based on data collected by the Michigan Department of Education. Database: College-going rate by high school Online Database by Caspio // Click here to load this Caspio Online Database. You can use this... Full story »
New high school graduates enrolling to college is down both in raw numbers and in percentage of the graduating class, based on state data for the Michigan Class of 2014. Full story »
When Portage voters go to the polls Tuesday, one of the most significant decisions they will make is whether to authorize Portage Public Schools to issue two construction bonds issues totaling $144 million. Full story »
A Berrien Springs High School student was suspended Thursday after threatening to bring a gun to school, according to a news release from the Berrien Springs-Oronoko Township Police Department. Full story »
Breakdown of the two Portage Public Schools bond proposals on the Nov. 3 ballot. Full story »
Voters on Nov. 3 will decide on a $16 million bond issue – Proposal 2 – that would build a new stadium at each of the high schools. The multi-purpose athletic and event stadiums would have artificial turf and new locker rooms, track and field facilities, bleachers and other improvements. In addition, supporters emphasize, the new stadiums will be not just for football but also practice and playing fields for the marching bands, soccer, track, physical education classes, lacrosse and community events. I Full story »
On Nov. 3, Portage Public Schools voters will have a chance to approve a $128 million bond proposal that would build new Central and North middle schools, remodel West Middle, construct a swimming pool at each of the high schools, purchase 30 new school buses and acquire instructional technology that could lead to a computer or tablet for every student. Full story »
The Loy Norrix Knights celebrated homecoming on Friday, Oct. 16, 2015 during the game against Portage Central. Full story »
National Lights On Afterschool Awareness Day is Thursday, Oct. 22, and Kalamazoo Public School students will be doing their part to shed light on the need to invest in afterschool programs. Full story »
While enrollment is mainly flat this fall among Kalamazoo County's regular public school districts, the student count at charter schools serving the general population fell 14 percent compared to fall 2014, according to figures supplied this week by local school officials. Full story »
A charter school leader who has drawn accolades in Muskegon, Grand Rapids and Detroit for his work with dropouts and young adults struggling academically is planning to open a school in Kalamazoo. Full story »
A parent workshop on developing the social skills of gifted children is set for Sept. 28 at the Kalamazoo Regional Educational Service Agency, 1819 E. Milham Ave. in Portage. Full story »
Shannon Houtrouw, a computer science teacher at the Kalamazoo Area Math and Science Center, has been selected as a Michigan finalist for the Presidential Award for Excellence in Mathematics and Science Teaching. Full story »


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Medications and Drugs
Brand Names: Gastrocrom
Generic Name: cromolyn sodium (oral) (Pronunciation: KRO moe lin SOE dee um)
What is cromolyn sodium oral (Gastrocrom)?
Cromolyn sodium is an anti-inflammatory medication. It works by preventing the release of substances in the body that cause inflammation.
Cromolyn sodium oral is used to treat the symptoms of a condition called mastocytosis, which can cause diarrhea, nausea, vomiting, headaches, stomach pain, itchy skin, and flushing (warmth or redness under the skin).
Cromolyn sodium oral may also be used for other purposes not listed in this medication guide.
What are the possible side effects of cromolyn sodium oral (Gastrocrom)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
Less serious side effects may include:
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about cromolyn sodium oral (Gastrocrom)?
You should not use this medication if you are allergic to cromolyn.
Before you take cromolyn sodium oral, tell your doctor if you have kidney or liver disease.
Do not give this medication to a child younger than 2 years old without the advice of a doctor.
It is important to use cromolyn sodium regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
Contact your doctor if your symptoms do not improve within 2 or 3 weeks of taking this medicine.
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Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Need help identifying pills and medications?
From WebMD
Allergies Resources
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I checked on my Windows 7 PC. I've got 11 folders called "iTunes" (note the capital T), and 0 folders called "itunes".
I assume they aren not on a locked disk (both my c:-drive and my p:-drive are in use when I use Firefox), but I didn't check the write permissions for all 11 folders. That's easy to do. Either check the permissions in the folder properties, or copy a file into it (delete it afterwards).
I just started getting this message when I open Itunes - "The folder "itunes" is on a locked disk or you do not have wriet permission for this folder". Any help please?


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I married at the age of 22, when I took out a mortgage.
We did not start a family until I was 30, because it was only then that we could afford it. We had no such thing as child allowance in those days.
I worked all my days and retired with a small works pension, which is taxed, so it annoys me when I hear how the nation faces pension problems, because we are all living too long.
My message is simple; if you cannot afford things, whether they be a house, a car or even a family, don't complain that others have things that you don't have.
Name and address supplied
City slipping up
I'M just back from a visit to Birmingham. There is a lot of regeneration going on there, but there was no sign of any litter and the pavements were all first class.
Arriving back in Glasgow, I walked up Union Street/Renfield Street. What a disgrace! The pavements are all old, with mixed surfaces, broken down or nonexistent, and there were puddles and litter everywhere.
MC Cumbernauld
Airgun crime
I read the article "MacAskill hails airgun law reforms" (June 16) with amusement.
Aside from Mr Mac-Askill's self praise, he continues to use emotive arguments to push this his agenda to license airguns.
While I can understand that, on the surface, an airgun licensing scheme may seem like a good idea to those that are swayed by Mr Mac-Askill's emotive arguments, airgun crime is almost nonexistent in Scotland and there is no evidence to support his claim that licensing is required, or indeed will prevent criminal use.
Dave Ewing Founder No to Airgun Licensing In Scotland Campaign
Park drinkers
It has been great to get out and about in Glasgow in this lovely weather.
I have been making use of Bellahouston Park, but it doesn't take long before you turn a corner and there you find the police moving on illegal drinkers.
Only in Glasgow.
Name and address supplied
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text:
Episode description: Bill sits down with Dr. Whitney Jones, a Louisville gastroenterologist who founded the Colon Cancer Prevention Project with the mission to eliminate preventable colon cancer death and suffering by increasing screening rates through education, advocacy, and health systems improvement in Kentucky. A 2010 KET production. Watch Online
Series Information: One to One with Bill Goodman
TV Schedule
No Upcoming Airdates.
Past Airdates:
- KETKY: Friday, August 2, 2013 at 1:00 pm EDT
- KETKY: Monday, March 18, 2013 at 12:01 pm EST
- KETKY: Thursday, November 1, 2012 at noon EST
- KETKY: Wednesday, June 6, 2012 at 1:00 pm EDT
- KETKY: Wednesday, January 11, 2012 at 1:00 pm EST
First aired: Sunday, April 4, 2010 (excluding any air dates prior to June 1999)


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The SpaceUp Foundation is a 501(c)(3) non-profit public benefit organization incorporated in California. The Foundation provides tools, funding, and organizational support to SpaceUp unconference events around the world in order to foster collaboration, outreach, and project-based learning between space professionals, advocates, students, educators, and scientists.
Chris Radcliff, CEO (@chris_radcliff) is an author, technology speaker, software engineer, and long-time unconference participant. Chris founded SpaceUp in San Diego and will happily dance like a monkey to spread space unconferences around the world.
Jesse Clark, COO (@jessesclark) is a systems administrator, pilot, and space advocate. He founded the San Diego Space Society, directed the Young Eagles program for the San Diego chapter of EAA, and organized the very first SpaceUp.
You? The SpaceUp Foundation is currently searching for a space enthusiast with a passion for social media to serve in a volunteer role as our Community Manager. Please email us at firstname.lastname@example.com if you know someone we should talk to.
Board of Directors
Cariann Higginbotham (@cariann) is a frequent SpaceUp participant, co-host of the TMRO weekly webcast, and barista at SpaceX. Cariann will happily make Chris dance like a monkey to spread space unconferences around the world.
Cindy (@txflygirl) is a Systems Engineering & Integration Engineer with International Space Station, Constellation, and Commercial Crew experience. She holds an MBA and is an educational/participatory outreach advocate. She founded SpaceUp Houston and served as the Executive Director from 2010-2013.
Marimikel Charrier (@marimikel) is a professional space and science evangelist. Marimikel organized the first SpaceUp San Francisco and co-founded the SpaceUp Foundation.
Remco Timmermans (@timmermansr and @SpaceUpEU) is part of the team that brought SpaceUp to Europe. He serves as an advisor to local organizing teams and is an active advocate for SpaceUp outside North America in general. So far he has attended ten SpaceUp events in Europe, with the eleventh just around the corner. He is the Operations Director of the World Space Week Association, does some Arctic Expedition and Social Media stuff and is a proud recent ISU SSP13 alum.
Local Organizers
Each SpaceUp is organized by a local team of space community and unconference leaders. Some of the usual suspects include:
- Dennis Bonilla – SpaceUp DC
- Eric Gever – SpaceUp LA
- Michael Clive – SpaceUp LA
- Michael Doornbos (@mrdoornbos) – SpaceUp DC
- Sam Coniglio – SpaceUp San Francisco
- Sarah Worthy (@sarahmworthy) – SpaceUp Houston
- Scott Norman (@scottnorman) – SpaceUp LA
- Tristan Moody (@SWGlassPit) – SpaceUp Houston
- Alex von Eckartsberg (@StarlingLX) – SpaceUp Europe and Cologne
We also keep a Twitter list of SpaceUp organizers. Are you a SpaceUp organizer? Email us if you would like to be in either list.
Contact Us
Excited about having a SpaceUp near you? We have tips on how to start your own SpaceUp and get connected with other SpaceUp organizers around the world.
If your SpaceUp could use organizational, financial, or promotional support, email email@example.com and we'll see what we can do to help.
Or you can write to us at SpaceUp Foundation, 325 W. Washington St. #2229, San Diego, CA 92103


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Select Local Merchants
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Prom Dress Trends for 2015
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Hollywood Red
A classic red gown never goes out of style. Nicole Kidman, Taylor Swift, Emma Stone, and many other celebs have had memorable fashion moments in red gowns on the red carpet, so go ahead and rock some red on your special night! Opt for trendy accessories, like a spiked clutch or shoe, to keep this traditional look fresh.
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