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Joined: 25 March 2010
Posts: 314
article about sushant sayin that ...
Did Sushant Singh Rajput anger Ekta Kapoor?
The television queen has nothing positive to say about the actor who recently quit the show
It seems all is not well between Ekta Kapoor and her protege, Sushant Singh Rajput. The latter quit her show Pavitra Rishta last month as he did not want to play an older character. The show is taking a 20 year leap and Sushant, we hear, did not want to essay a man approaching his fifties. So he opted out and Hiten Tejwani stepped into his role of Manav Deshmukh. This has definitely not gone down well with Ekta. At an event announcing the show's 20 year leap, Ekta said cuttingly, "Jo TV chhod dete hain, unhe TV chhod deti hai." (Those who leave TV should know that TV will leave them). A barb straight into Sushant's heart, perhaps? She also refused to answer any question about Sushant. Looks like Sushant's departure was as much of a shock to Ekta as it was to ardent followers of the show. After all, Pavitra Rishta brought Sushant fame, wealth and love, and he is engaged to Ankita Lokhande, who plays Manav's wife on the show. Ekta had to fall back on her replacement star Hiten, who was only too willing to be a part of the show and replace an actor once again in his career (he had earlier replaced Manav Gohil in Kkusum and Cezanne Khan in Kasauti Zindagi Kay). Does this mean Sushant will end up like Kaisa Yeh Pyaar Hai's Iqbal Khan who was thrown out of Ekta's camp forever?
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Release date:
September 14, 2007
Studio: First Independent Pictures
Director: Andrew Black
MPAA Rating: PG-13 (for some drug content, sexual references and crude humor)
Screenwriter: Ben Gourley
Starring: Ben Gourley, Mila Kunis, Jon Heder, Rutger Hauer
Genre: Comedy
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Official website: MovingMcAllisterthemovie.com
Plot Summary:
Rick Robinson is a ladder-climbing law intern from Miami with four days until the Bar Exam. Desperate to score points with his boss (McAllister), he commits to a favor he can't afford. He ends up in a rundown truck headed to L.A. with his boss's possessions, his Hollywood-bound niece, and her pet pig. Amidst hitch-hikers, breakdowns, and assorted local yokels, Rick finds love, life and maybe himself in this trans-American road trip from hell.


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"Bira or Antsirabe" Antsirabe by Norali
Antsirabe Travel Guide: 43 reviews and 147 photos
170 km from urban Tana, it epitomizes "Little Europe" in Madagascar. Yet, people there are real Malagasy, Merina indeed, and Antsirabe belongs to Antananarivo province. There are now reported 200 000 inhabitants in this capital city of Vakinankaratra region.
Worth noticing: it is the coldest place in Madagascar and located at an altitude of 1500m.
This kind of landscape is what you would see in your way to Antsirabe. Cultivated plots. Ricefields. Cascade pineapple fields. Rocky mountains. Pinewood & eucalyptus woods.
Along the road, you will see stalls that sell tiny tin cars (made from recycled cans); little brightly-coloured -wood trucks... as well as boiled or grilled corn on cobb in Easter... Yummy! Find there fruits: pineapple, strawberry, quenchy and sweet apples and peaches... as well as poultry :-) The region known as the orchard of Madagascar also sells flower species along its route... Orchids, anthirium types, roses, begonia, rhodos...everything that can grow is here provided it is not from a too cold country (Canadian blue pine doesn't grow here, for instance, let alone in other parts of the island. Tulips neither.).
Anyway, this is a trip I appreciate. Not too long & for a destination that is yet different from urban Tana. 3 hours are enough.
Maybe a personal tie with Antsirabe: though my Dad's family comes from North of Tana (where my place Malaza is), my grand-parents established themselves in this area. They have a house built in Bira. This large family of 15 kids lived there till children (my uncles and aunts) moved to Tana for study or work. Now, they live either in urban Tana either in Malaza where they all have inherited plots of land from my grand-parents. My grand-ma always lived there exception her last months on earth. Only two aunts (out of 15 kids) stayed in Antsirabe... But then, some cousins who lived in Tana have found jobs in the industrial companies in Antsirabe region.
For a sentimental reason, my uncles, aunts and parents use to bring here kids to be baptised in their Anglican church. I admit that this is greatest reason why this family really enjoys returning there, me included. Easter and Xmas are special there. I was there Dec 2005 for Christmas & Apr 2006 for Easter. When is next ? [Update Feb 2008: There was the Sep-Oct 2007 stint] Wanna know the reason for this intro picture ? Hit the General Tips section !
Circa 1872, Norwegian missionaries established there to escape from heat in coastal cities. So, later, did the French. They still stand there now, with involvement in agricultural and breeding research. The region uses to welcome Belgian (at least, from Gembloux university), Norwegian academics and cooperation staff members.
This region provides other regions (esp. Tana) with flowers, fresh fruits and vegetables as well as dairy products. Industrial plants produce national brands' products: Tobacco plants, Cotona (cotton fabrics), Hasyma (cultivates and processes cotton, cotton mills), Star (beverage producer and brewer)... You name it, Three Horses Beer, (THB), National beer is theirs. Visy Gasy (or Malagasy Vichy), the sparkling mineral water, has its sources there as well. Another spring water has its source from the mountains on your way to Antsirabe (in the Vakinankaratra region).
Plants and industrial premices are seen at the entries (both when coming from Tana and coming from South)
While Toamasina and Mahajanga welcome great influxes of holidaymakers during winter holidays (July to September), Bira welcomes holidaymakers in Easter holidays.
Go there to relax as the city is really calm, safe, rather clean. Antsirabe is also the trade place for precious stones that are extracted in Southern Ilakaka. You may buy things there but, don't buy in the streets if you are not a connoisseur.. See my tip on that :-)
Tritriva and Andraikiba lakes are worth seeing. Both have their own legend. Ask your guide to arrange a trekking there.
**Picture is of a truly European style villa. This restaurant serves, in fact, Malagasy food. I'll check about the name. Have never tried it there but was told the food is OK...**
Surely, its European style comes from history.
Here and there, you will find many buildings, houses whose styles are European inspired ones. Traditional Highlands houses with balcony (lavarangana) adjoins with French cottage- style house and Scandinavian villas. Gardens in front of houses are of English style. Some buildings just look like mountain huts somewhere in Switzerland... The whole set is rather unified though... Flowers, trees, large avenues are common to most of corners.
Don't miss its daily market in Asabotsy. Great influx there on Saturdays (Asabotsy). You will there products from all over the island.
Thermal spa exists since Norwegian families started exploiting springs of Antsirabe area centuries ago. Later, the French developed this business. Here is the picture of Les thermes, a thermal spa. Antananarivo royal family (Ranavalona II and her sons) used to have a stay at the spa. However, I am not sure it works well at the moment. I know it had to be restaured and was closed for this purpose but I do not have any update of the advancement of works.
- Pros:Quiet city, rather clean, smooth people
- Cons:Too quiet if that matters
- In a nutshell:A place to relax with interesting sightseeing
Reviews (35)
Now, Bira is not the ideal city for crazy clubbing nightlife. Only a handful of clubs (2 or 3). Anyway, even in Tana,... more travel advice
Probably nothing else could epitomize Antsirabe in my eyes better than this: a Singer sewing machine. My Dad's family... more travel advice
I was hanging around the ochre mosque that morning. Adjusting lenses to take pictures of the sun shining behind the... more travel advice
Shopping (5)See All Aluminium trinkets in Ambatolampy
Warnings and Dangers (1)Easter traffic jams
Hotels (2)See All A hotel with some history
Things to Do (4)See All Roam the city... to relax
Local Customs (2)See All Men use to wear (wrap up with) lamba
Comments (15)
Great tips!
0°C en hiver ? incroyable en plein océan indien...
I love travelling through your eyes. Almost as if I were there.
Very interesting updates, Norali. Thank you.'njoy what is left of the weekend!:~))
Excellent tips and pictures of this exotic remote location. Thank you.
I would not have thought bringing warm jamies to the Island......superb reading, excellent tips and great pics, from a land I don't knew much about. tanx for sharing
Excellent inside information. Thank you.
Thanks for the information about this part of the world ! Rather unknown for me and other VT'rs So thx again -this tips are what VT stands for !
Yes, King... Hotel des Thermes is not the best but most expensive. My fave is Arotel, both for services and food.
I stay at Hotel de Thermes and so it wasnt the best hotel in town after all... :(
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More 2011 Hustler problems
Besides cut quality being an issue, now my Super Z broke the deck belt at 166 hours. Throttle cable melted on the block and bound up. Fuel tank vent broke. Both gas cap keeper strings are tangled around the fuel lines in the tank and the caps barely come off far enough to get a fuel nozzle in there. My friends X-ONE only has 68 hours on it and the deck drive belt is coming apart also. So far we are not impressed.
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Man, you've had some crap for luck with that thing! Sorry to hear all this.
Most guys who have a Hustler, like 'em, and really brag 'em up. I suppose it could be a fluke or something, but your friend is having troubles too. Doesn't sound to good so far for 2011.
Still have the Scag? If so, I think I'd stick to using it.
I know that feeling. I used to own a Super Z. One good thing is Hustler will usually give you a loner when your down. Makes you wonder how much testing they actually did on that model. I bought the Super Z when it first came out, nothing but problems, I guess never buy a new model the 1st year it's in production , or you can end up regretting it. I hope you get it resolved then trade it .
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2000 Exmark Lazer Z 60" L/C Kawi 4100 + hrs strong
Out of all the things you have mentioned I can see only one that appears out of line for its age and the number of hours,
as for the rest you are going to see wear and tear that is going to result in little things falling apart at first followed by slightly
bigger things later and so on as they don't last forever... Unfortunately if they say that a Ztr lasts a thousand hours it's not going
to stay in one perfectly healthy piece for all 999 hours of that and then fall to pieces at the very last second, what happens
instead is it breaks a little bit here and there all along the way, and that is what you are seeing and I believe this to be normal,
at least I think it is.
As for that one piece that broke that shouldn't have, it happens.
It shouldn't but then it's also not a hydraulic motor that went, even in the first 1-200 hours you are going to have knick knack break
and yes it could happen some of that falls in the space of $50-$100 knick knack, again it shouldn't but...
That having been said I found the vent pieces breaking off the gas cap rather annoying as well, both of mine are long gone.
Last edited by topsites; 08-04-2011 at 01:40 AM.
2013 Exmark Pioneer S 60" Ultracut (Review with pics) http://www.lawnsite.com/showthread.php?t=410996
2010 Badboy Outlaw 6100 31 KAWI
2008 Exmark Lazer Z AS 60" U/C 28 Kawi
2000 Exmark Lazer Z 60" L/C Kawi 4100 + hrs strong
I'm about to pass 300 hours on my original deck belt on my Gravely. No cracks, slits, or any visual defect with it yet.
I shouldn't sound so harsh I guess because they did replace everything wrong under warranty except the belt which is now $128!!! Ouch! I usually put approximately 300 hrs a year on my mower also. On Hustlers I have only had to replace the hydro belt around 300 hrs, but usually got a season and a half to two seasons out of a deck belt. The cut quality coupled with all of these little problems is getting to me. They do offer a loaner when they go down, but since I have the Scag I usually just run it. We are starting to wonder if the poor cut and early belt breakage are related?????? All the spindles spun freely when the belt was off. That was my first assumption. Maybe I need to check all the other pulleys??
I would be more than willing to sell it if anyone is interested!! LOL! Getting offered less than 50% of what I paid for it for trade on something else. I would rather help someone else out that needed a mower than let the dealer profit, but would I really be helping someone else with all of the issues I'm having and the warranty non-transferrable?
I guess it is just kind of my venting, but I also want others to be aware of the issues we are having. Had good luck until this year. Been eyeing Exmarks. Dealer really wants to get me on one. My original 2005 Exmark is still going strong that I sold to a neighbor!!
I have to say, that most of that stuff is normal wear and tear stuff. I have a few folks that buy a $8000 mower and never expect anything to go wrong. I had a guy in here monday that he had a switch go out with 73 hours on his mower, his fuel guage will get steamed up and he can't read it if it sits in sun to long, and his blades were ate up and he had to get another set. He said he wanted to sell it because he didn't expect to ever fix anything on it since it wasn't a $1000 craftsman or wal mart mower like he had been getting. After handing him a switch (for free, under warranty), asking if he wanted another fuel guage (again free, and I explained to him they don't always tell the truth to actually open the cap everyonce in a while to double check), and handing him a set of blades (only to ask him if he wanted me to throw them on for him, free, after going through the whole blades hit things therefore wear out and have to be sharpened, and god forbid replaced). $50 for all that knowledge, and he was still pissy....lol. I am just trying to say, sometimes bearings, pulleys, belts, pumps, motors, decks break, frames break, catch on fire, leak, doesn't work properly, and sometimes they don't and go for 1000's of hours without issues, it just happens. Give it some time, and try to justify some issues, its when you get slammed with a ton at one time when it feels like you got a lemon.
Good example, I have one mower that went over 1500 hours with no belt, bearing, pulley, nothing but a 25amp fuse that got corrosion on it (after flipping down a highway. Then my new mower same set up, I burned a belt mowing my first day, had 2 idler pulleys cease up in less than a month, had a wheel bearing go out, in the same year had a spindle bearing go out on the chute side, and thought I had ruined the engine after hearing awful clattering coming from it, but after opening it up realized the main bolt going down the center was backed off, and put over 23 plugs in my tires. To some people that sounds excessive, but really all of that was normal maintenance items, or what we call dreaded "wear and tear", I fully expect when running a crew, but I really feel I am harder on equipment than most of my guys were. I could rant and rave and blame bearing companies, pulley people, belt factory people, say kawasakis are pieces of crap, say the mower manufacturer builds crap, but all in all when you are using equipment on a daily basis expect stuff, its hit and miss. For normal 200 to 400 hours a year I say to sit back atleast $100 to $200 for oh crap stuff, and anything over 400 a year sit back $300 to $400. When you don't break anything you have a sweet nest egg, but when you do you have it there and were expecting it, makes since when you have a tranny blow, or an engine, tire pop on the sidewall, or like my newest customer the other day....his 2 year old Gravely cracked the deck from front to back in the middle, and instead of buying a new deck for $2000 and putting it together his self with his old nuts, bolts, spindles, etc, he came in and financed a new mower..... Some companies will replace under warranty, and some will say it was the users fault, kinda like playing lottery.....
Kinda cool about Hustler, they have great customer service, and will go over and beyond your expectations on your issues, so hopefully your negative feelings will turn positive when the rep fixes your cut issues, and figures out a spot on the new belt system stressing belts out more than normal and retrofits a pulley with a spacer, or takes one out.... Sorry for the long post, I just want you to feel better about your purchase and not make your negatives influence people into thinking an exmark, gravely, or a scag would have been a better purchase for you because they have never had these types of issues, or vice versa influence you into loosing you butt and trading in swapping freaking brands, I see that alot, and yes, I have got hella good deals, on even exmarks, and scags less than one year with the same "this things a piece of crap" mentality people feel with their new purchases..... Truth is you and your buddy could get the next serial # machine exactly the same as you have, and it might cut perfect, and never break anything, I know its weird they are identacle in every way, but its true......happens all the time....
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there's a remedy for that...it's called quality control at the factory where they are built lol
The new fuel tanks....Don't like them at all. I'd snip the lanyard, and let it drop to the bottom. Never lost a fuel cap in my 30+ years of mowing, doubt it'll happen anytime soon.
The deck belt.... What height are you cutting at?
I know on my older SuperZ, that I get the best deck belt alignment at about 2.5" !!! Any higher of cut and the belt has to bend up a bit after the clutch pulley, and then pitch down when it gets to the deck (deck pitch 1/4" forward).
If this wasn't addressed with the new SuperZ, then this could be an issue as the idlers are all different now. That big pizza plate one may be causing heat as it's contact (scrub) patch is larger than the old small 8" idlers. Just a thought.
I've only had 2 deck belts snap in 5 years. Both were after rainy/high humidity where clutch was overly grabby.
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speed paint doodle by angelbreedWatch
©2010-2016 angelbreed
quick painting of Crystal-for-ever character Natasha
Natasha (C) Crystal-for-ever
Natasha (C) Crystal-for-ever
I am so sorry it took me so long to notice this, I don't really go on DA much anymore and I was looking around on search and I saw this lovely gift you did of my character Natasha. thank you so much, she looks really amazing in your style and how you did the colors and her outfit. so wonderful and lovely!! thank you so much!! I really appreciate it so much!! ^O^
You know how to paint well.
How you do that dude?!
How you do that dude?!


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|Joe Harford
Joseph Harford, co-founder and VP of Sales at Reclamere Inc., has passed his Certified Information Privacy Professional (CIPP) exam, the industry standard certification to demonstrate a strong foundation in U.S. privacy laws and regulations as well as an understanding of the legal requirements for the responsible transfer of sensitive personal data to and from the United States.
The CIPP exam is offered by the International Association of Privacy Professionals. Founded in 2000, the IAPP is the world's largest association of privacy professionals, representing more than 7,000 members from businesses, governments and academic institutions across 52 countries.
Reclamere was founded in 2001.
Security assessments involves reviewing an organizations policies and procedures to mitigate risk. Data recovery involves retrieving lost data on a computer's hard drive that crashed or suffered a catastrophic failure. E-forensics involves finding the hidden or deleted data that resides on a computer's hard drive using a specific software program and a certified examiner. E-forensics is necessary to protect the integrity of the data if the information is being obtained with the possibility of using it in a legal proceeding.


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Featured news
Phishers tapping botnets to automate attacks
Scam emails that form the basis of phishing attacks often pose as 'security check' requests from well-known businesses. These messages attempt to trick users into handing over their account details and passwords to bogus sites. The details collected this way are used for credit card fraud and identity theft. First seen more than a year ago, phishing emails are becoming increasingly sophisticated, directing users to bogus websites which accurately reproduce the look and feel of legitimate sites.
By John Leyden at SecurityFocus.
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The Sin of Usury
Recently, on the Call & Response blog, http://faithandleadership.com/blog/02-22-2010/dan-rhodes-congregations-s...
My friend Irene Groot decided to try the Lenten Experiment this year. "I recently sent off a couple of hundred dollars to a local soup kitchen," she e-mailed me this morning. "That's the money I saved taking up your challenge."
This time of year I find myself humming the Olympic anthem throughout the day. The Vancouver games run Feb. 12-28; it is time to start dreaming of mogul runs and bobsled victories. For some reason I hum the familiar tune associated with the games on my way to and from errands. As if hauling my three children around were an Olympic event in and of itself.


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I'm 29 weeks and it seems like this week I have just been super emotional. Anyone else?
Anyone else really emotional?
Yep, 24-7 lately. :/
~Cristina~ DH Greg
12/18/03 Lauren Rose & Connor Reed
1/25/13 Savannah Marie
I have been so miserable this week. Feel like curling up on my bed the whole day!! nice to know am not alone..
Oh, holy cow, YES! I cannot seem to get myself under control and all the emotionas are exhausting me! Going to try and take a nap and calm myself back down.
I'm crying right now...
Proud Coast Guard wife!
Mama to Miss Annabelle ((1/9/13)) the BEST thing that has ever happened to me.
Emerald Boobies!! ( . Y . )
Candy (27) + Akaido (31) married 11/12/11
Expecting First baby together 1/1/13,
Maryland Mommas Let's enjoy Crab Season!
I spent all day crying yesterday. My poor 4 year old was asking "Why are you crying AGAIN?!?" and when I had a bath at the end of the day (while he was in there pooping) he said "You're not going to cry in the water, right?" (but I did)


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Master European Governance
- On Campus
- 24 months
- EUR400 Year (Non-EEA)
- English, French ( Take IELTS test or Find a course )
Taught in the heart of one of the principal institutional centres of the European Union, the University of Luxembourg's (Luxemburg) innovative new bilingual (English/French) Master in European Governance distinctively combines:
The Masters degree builds upon the research programme in European Governance established in 2004, which brings together over 25 collaborators.
The principal objective of the Master in European Governance is to educate experts in European public policy, providing an advanced-level training in Political Science complemented by a wider interdisciplinarity. The programme permits students:
200 / semester
TOTAL (cours obligatoire / cours optionnel): 30 ECTS
TOTAL (cours obligatoire / cours optionnel): 30 ECTS
Semestre 4
Candidates must normally have completed a Bachelor�s level degree (180 ECTS) in Political Science, Law, Economics, History, Philosophy, Sociology, or another relevant area in the Social Sciences and Humanities. Admission may also be made on the basis of relevant professional experience (minimum three years), in accordance with the relevant national legislation.
Candidates must also have the requisite levels of competence in English and French (see below).
Entry to the programme is competitive on the basis of the submitted dossiers, and limited to 25 places per year. The admissions committee reserves the right to interview individual candidates (in person or by telephone) where this is deemed necessary.
Submit a detailed application dossier which must include the following:
No work experience is required.
Fortunately enough I was able to find StudyPortals. Right from the start of the application to getting the confirmation of admission I was using StudyPortals.
Sign up for your personal newsletter and we will help you too.
We will send you all the information you need to find your dream study programme!
Together with the ISIC Association and British Council IELTS we offer you the chance to receive up to £10000 to expand your horizon and study abroad. We want to ultimately encourage you to study abroad in order to experience and explore new countries, cultures and languages.
If you choose to study or do your research at the University of Luxembourg, you will be part of a young and dynamic institution seeking growth, to which you, as a student, researcher or lecturer, can contribute, and actively participate in its development process.
Prepare yourself for Master degreeFind a Preparation Course


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I'll play some more.
Dunno what to tell ya' about the mixer control... Windows can get the levels to full mute.
Printable View
I'll play some more.
Dunno what to tell ya' about the mixer control... Windows can get the levels to full mute.
Well I had to go back to rc4. RC4.1 wouldn't work on my rear speakers or sub. idk what you did but its weird. I mean the sliders don't work right at all. I move it up it goes up but nothing happens. I mean what ever you did to RC4 made my rear and sub work but now its like it was removed in 4.1 and screwed up in the mixer bad.
Forwarding to the next song takes around 1-2 seconds. In RC4 pressing on the next song button would play the next song imediatly, now it doesn't do anything for 1-2 seconds (doesn't react to key presses, no sound) and then plays the next song.
This bug is there since RC1 and I've pointed it out everytime. This time it got even worse. You don't seem to filter the id3tag fields correctly it seems, because there is a square character behind the album name, in this version more albums are affected. Real showstopper! BTW: Neither foobar2k, itunes, wmp nor Winamp show these characters.
I'll attach an image this time, so I hope it get's noticed!
I can't install 4.1
I got this message "The system administrator configured the policy of your system to forbid this installation ".
I have got this message on 2 different PC.
This is the first time I got it. I have successfully instal RC3.
EDIT: It seems that it is cause by a corrupted installer...
I must say... Excellent Project :rock:
I am having the same problem as "bns2000".
1. My rear speakers and sub no longer work. Although they were fine the last 1-2 versions.
2. When I tried my HQCT I hear the radio station playing but I can not change the channel or get any readouts. Seems like the USB connection is not setup correct. HQCT does work in RR on the same machine... :)
3.a. During initial import of my songs (2000), it took more the twice as long.
3.b. When I went into the media selector and chose that directory the initial spool up time(till I could listen to the songs) was 1-2 minutes.
3.c. When I clicked the next button (media player, 2000 songs) with random selected I got a skin freeze of 1-2 minutes.
if that's 2000 tunes in one directory then I'm not suprised :p
my external apps won't work, buttons are blank. They show in the settings list but I cannot select them in the button actions list.


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The secret is what you do before and after: from marinades to salsas, 20 recipes from top chefs.
Gathering around the backyard grill is not usually a dress-up occasion--at least, not for the people involved. For the meat or chicken or seafood headed for the flames, it's another story. A little dressing up--a marinade or rub before grilling or the perfect sauce or salsa afterward--can bring out the best in an ordinary cut of meat or an unremarkable piece of poultry or fish.
Here are 20 "before and after" recipes from 13 chefs and four cookbook authors--10 marinades and glazes, two rubs, six sauces and two salsas--along with four recipes for simple vegetable accompaniments. These 20 extras feature flavors from around the world, from an Asian fish sauce with only four ingredients to a Brazilian coconut marinade and a blueberry twist on that all-American favorite, ketchup.
PUBLISHED June 1996


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Article Summary
Robofun, which bills itself as the largest open-source hardware store in Romania, has built a robotic bartender called The Social Drink Machine. It takes its inspiration from another recently created "botender," The Inebriator, which the team at Robofun felt could be improved with a social media interface. They built their own robot from scratch in just 10 days and added Facebook and Twitter apps that let you order drinks from a mobile phone.
Read the full article: The Social Drink Machine takes your order via Facebook and Twitter
Related Articles


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Are you Maureen B. Maude?Claim your profile
Publications (46)141.34 Total impact
Article: Low docosahexaenoic acid levels in rod outer segments of rats with P23H and S334ter rhodopsin mutations[Show abstract] [Hide abstract]
ABSTRACT: Previous studies have shown that the level of docosahexaenoic acid (22:6n-3, DHA) is lower in the rod outer segment (ROS) membranes of dogs and mice with inherited retinal degeneration than in ROS from appropriate controls. In the present study, we analyzed the ROS fatty composition of several lines of transgenic rats with P23H and S334ter rhodopsin mutations. Lines were chosen that have different rates of retinal degeneration. At 21-22 days of age, animals were perfused and eyes fixed and sectioned for morphologic examination. Others were killed and retinas isolated for preparation of ROS by sucrose step-gradient centrifugation. Fatty acid composition of ROS phospholipids was determined by gas-liquid chromatography. Membrane purity was assessed by polyacrylamide gel electrophoresis. Retinas of the slow degenerating lines were indistinguishable from controls, whereas there was a 15-20% and 50-60% loss of photoreceptor cell nuclei in intermediate and fast degenerating lines, respectively. Except for the slow P23H line, all mutant lines had lower levels of 22:6n-3 and total n-3 fatty acids in ROS phospholipids, compared to wild-type controls, and the level of 22:6n-3 was lowest in those lines with the fastest rate of degeneration. The relative levels of the other fatty acid families (saturated, monoenoic, and n-6) increased proportionately. The n-6/n-3 ratio increased in the more rapidly degenerating lines, but the phospholipid/protein ratios did not change. The low levels of 22:6n-3 in the ROS membranes were not compensated for by an increase in 22:5n-6, which always occurs in the retina of animals where 22:6n-3 levels are reduced by dietary manipulation. Rats that express mutant rhodopsins have lower levels of 22:6n-3 in their ROS phospholipids than wild-type animals. We propose that photoreceptor-specific mutations provoke a metabolic stress in rod photoreceptor cells that generates an oxidant stress in these cells. The retina responds to this stress by reducing the level of substrate for lipid peroxidation (22:6n-3).
Article: Low docosahexaenoic acid levels in rod outer segment membranes of mice with rds/peripherin and P216L peripherin mutations[Show abstract] [Hide abstract]
ABSTRACT: Humans with retinitis pigmentosa and dogs with progressive rod-cone degeneration (prcd) have lower than normal blood levels of long-chain polyunsaturated fatty acids, including docosahexaenoic acid (DHA), the major fatty acid found in retinal rod outer segments (ROS). In addition, prcd-affected dogs have lower levels of DHA in their ROS than control animals. The present study was designed to determine whether mice that are heterozygous for the rds mutation and transgenic mice heterozygous for a specific rds/peripherin mutation (P216L) have lower DHA levels in their ROS and other tissues than do control mice. Wild-type (rds(+/+)) mice, mice with the rds(-/-) (null) and rds(+/-) mutations, and mice with the P216L rds/peripherin mutation on the rds(+/-) background were maintained in the vivarium under identical husbandry conditions, and tissues were removed from each group for analysis at approximately 2 months of age. Fatty acid compositions of total lipids from plasma, red blood cells, liver, and ROS were determined by gas-liquid chromatography. ROS purity from each group was determined by SDS-PAGE with silver staining. The morphologic status of retinas representing each genotype was analyzed by light and electron microscopy. There was no difference between rds(+/-), P216L on rds(+/-), and rds(+/+) (control) animals in the fatty acid composition of plasma, expressed as relative mole percent or as nanomoles fatty acid per milliliter of plasma. Small but statistically significant differences were found in 18:0 and C-22 polyunsaturated fatty acids of red blood cells. In the liver, the control animals had higher levels of 20:4n-6. In contrast, the ROS of control animals had levels of DHA that were 1.4 times that of ROS from either rds(+/-) or P216L on rds(+/-) mice of the same age. The reduction in DHA was not accompanied by an increase in 22:5n-6, which always occurs in neural tissues of animals deprived of n-3 fatty acids. SDS-PAGE of the three ROS membrane preparations showed that they were of identical purity. Mice heterozygous for the spontaneous rds/peripherin mutation or mice carrying the P216L mutation on this heterozygous background have a statistically significant reduction of DHA in their ROS membranes. The authors propose that reduction in DHA is an adaptive response to metabolic stress caused by the mutation.
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ABSTRACT: Previous studies in humans with a variety of inherited retinal degenerations have shown that they have reduced blood levels of docosahexaenoic acid (DHA, 22:6n-3) (ref. 1–10), the major fatty acid in photoreceptor rod outer segment (ROS) membranes11. The greatest differences are seen in people with x-linked retinitis pigmentosa7 and Usher's syndrome type II (ref 10). Since the gene defect in these two types of inherited retinal degeneration is different, it is not likely that the reduction in blood levels of DHA is due directly to the mutation. Until recently, none of the mutations identified in retinitis pigmentosa were found in genes encoding proteins that are involved in lipid metabolism. However, Zhang et al12 found that two forms of macular degeneration (Stargardt-like macular dystrophy and autosomal dominant macular dystrophy) map to a 0.6 cM interval on chromosome 6ql4 that contains a new retinal photoreceptor-specific gene, ELOVL4, which has sequence homology to a yeast protein that functions in the synthesis of very long chain fatty acids (also see chapter in this book).
Article: Effect of docosahexaenoic acid supplementation of lactating women on the fatty acid composition of breast milk lipids and maternal and infant plasma phospholipids[Show abstract] [Hide abstract]
ABSTRACT: To determine whether docosahexaenoic acid (DHA) supplementation of breast-feeding mothers increases the DHA contents of breast milk and infant plasma phospholipids (PPs), breast-feeding women were randomly assigned to 3 DHA-supplementation groups (170-260 mg/d) or a control group. Group 1 (n = 6) consumed an algae-produced high-DHA triacylglycerol; group 2 (n = 6) consumed high-DHA eggs; group 3 (n = 6) consumed a high-DHA, low-eicosapentaenoic acid marine oil; and group 4 (n = 6) received no supplementation. From before to after supplementation (2 and 8 wk postpartum), mean (+/-SD) maternal PP DHA increased in groups 1, 2, and 3 by 1.20 +/- 0.53, 0.63 +/- 0.82, and 0.76 +/- 0.35 mol% of fatty acids, respectively (23-41%), but decreased in group 4 by 0.44 +/- 0.34 mol% (15%). Breast-milk DHA of groups 1, 2, and 3 increased by 0.21 +/- 0.16, 0.07 +/- 0.11, and 0. 12 +/- 0.07 mol%, respectively (32-91%) but decreased in group 4 by 0.03 +/- 0.04 mol% (17%). Mean infant PP DHA in groups 1, 2, and 3 increased by 1.63 +/- 0.79, 0.40 +/- 1.0, and 0.98 +/- 0.61 mol%, respectively (11-42%), but only by 0.18 +/- 0.74 mol% (5%) in group 4. Correlations between the DHA contents of maternal plasma and breast milk and of milk and infant PPs were significant. Breast-milk and maternal and infant PP 22:5n-6 concentrations were lowest in group 2. DHA supplementation increases the plasma and breast-milk DHA concentrations of lactating women, resulting in higher PP DHA concentrations in infants.
Article: A hypothesis to explain the reduced blood levels of docosahexaenoic acid in inherited retinal degenerations caused by mutations in genes encoding retina-specific proteins[Show abstract] [Hide abstract]
ABSTRACT: Some humans and animals with inherited retinal degenerations (RD) have lower blood levels of docosahexaenoic acid (22:6n-3) than controls. As a result of recent studies, clearly the low blood 22:6n-3 phenotype is found in multiple RD phenotypes and no mutation thus far identified in humans or animals is involved in lipid metabolism. Therefore, it seems reasonable to suggest that the primary defect is not in 22:6n-3 metabolism, but rather in some common convergent pathway that ultimately leads to the reduction of blood and tissue 22:6n-3 levels. One possibility is that the different mutations produce a metabolic stress that provokes structural and biochemical adaptive changes in photoreceptor cells and their rod outer segments. If the stress is oxidant, the retina could downregulate 22:6n-3 and upregulate antioxidant defenses. How such a stress could lead to changes in blood levels of 22:6n-3 is not obvious. However, the consistent finding of the 22:6n-3 phenotype in many different retinal degeneration genotypes suggests that some form of communication exists between the retina and other tissues that serves to reduce blood levels of 22:6n-3.
Article: Effects of maternal docosahexaenoic acid supplementation on visual function and growth of breast-fed term infants
Article: Effect of diet on the fatty acid and molecular species composition of dog retina phospholipids[Show abstract] [Hide abstract]
ABSTRACT: Dogs were born to mothers fed commercial diets low or enriched in n-3 fatty acids and raised on those diets until they were about 50 d old. Retinas were removed, lipids were extracted, and total phospholipids were analyzed for fatty acid and molecular species composition. Animals from the low n-3 group had significantly lower retinal levels of 22:6n-3 and higher levels of n-6 fatty acids, especially 20:4n-6 and 22:5n-6. There was no difference in the retinal levels of 18:2n-6, and only small differences were found in saturated and monounsaturated fatty acids. The most dramatic differences in molecular species occurred in 22:6n-3-22:6n-3 (4.7 vs. 0.8%) and 18:0-22:6n-3 (27.6 vs. 14.4%); total molecular species containing 22:6n-3 were significantly lower in the low n-3 group (45.5 vs. 24.0%). Molecular species containing 20:4n-6 and 22:5n-6 were greater in the low n-3 animals (13.0 vs. 25.7%), as were molecular species containing only saturated and monounsaturated fatty acids (40.8 vs. 35.4%). These results show that modest differences in the amount of n-3 fatty acids in the diets of dogs can have profound effects on the fatty acid and molecular species composition of their retinas.
Article: Polyunsaturated fatty acids are lower in blood lipids of Usher's type I but not Usher's type II[Show abstract] [Hide abstract]
ABSTRACT: Previous studies have shown that persons with retinitis pigmentosa and Usher's syndrome have lower blood levels of long-chain polyunsaturated fatty acids (PUFAs). In this study, the fatty acid composition of phospholipids from plasma and red blood cells (RBCs) was compared in persons with Usher's syndrome type I; Usher's syndrome type II; or no retinal disease (control subjects). Blood was drawn from fasting volunteers and separated into plasma and RBCs by centrifugation. Lipids were extracted and phospholipids were obtained by thin-layer chromatography. Fatty acid methyl esters were prepared and analyzed by gas-liquid chromatography. There were no differences in plasma or RBC phospholipid fatty acid composition between control subjects (n = 54) and persons with Usher's syndrome type II (n = 20). However, all 20- and 22-carbon PUFA levels from RBCs of persons with Usher's syndrome type I were lower than those from control subjects and persons with Usher's Syndrome type II. Likewise, plasma levels of 20:3n-6, 20: 5n-3, and 22:6n-3 were lower in Usher's syndrome type I compared with the control group. In contrast, plasma levels of 18:1n-9 and RBC levels of 16:0 and 18:1n-9 were higher in the group with Usher's syndrome type I. Plasma and RBCs from Usher's syndrome type I, but not type II, have lower levels of long-chain PUFAs than plasma and RBCs from control subjects.
Article: Diets enriched in docosahexaenoic acid fail to correct progressive rod-cone degeneration (PRCD) phenotype[Show abstract] [Hide abstract]
ABSTRACT: Results of a previous study show abnormal plasma lipids in progressive rod-cone degeneration (prcd)-affected dogs, with lower docosahexaenoic acid (DHA; 22:6n-3) and cholesterol levels but no differences in other plasma fatty acids, lipids, triglycerides, and fat-soluble vitamins. There is also an increase of the DHA precursor 22:5n-3, so that the ratio of 22:5n-3 to 22:6n-3 is higher in affected than in normal dogs. Because DHA is the predominant esterified fatty acid in rod outer segment (ROS) phospholipids, these findings suggest a possible causal association between abnormal plasma lipid levels and retinal degeneration. In the current study, dietary supplements rich in 22:6n-3 were used to determine whether plasma, liver, and rod outer segment phospholipid composition can be altered to modify the prcd disease phenotype. prcd-affected and normal control dogs were given DHA-enriched supplements for short (7- and 25-day) and long (21-week) periods, and the fatty acid composition of plasma, liver, and rod outer segment phospholipids were examined. In the long-term study, electroretinography and morphology were used to assess modification of the retinal degeneration phenotype. Administration of DHA-enriched supplements resulted in increases in plasma DHA and n-3 polyunsaturated fatty acids and in decreases in some n-6 fatty acids in normal and prcd-affected dogs. Similar increases in DHA and n-3 fatty acids were observed in the liver, but affected dogs had significantly higher levels at all supplementation time points examined. In contrast, the ROS of affected dogs had statistically lower (approximately 20%) DHA levels, and these levels could not be increased with dietary supplementation. The disease phenotype could not be modified by DHA-enriched supplements. Regardless of the sustained three- to fourfold elevation in plasma and liver DHA that occurs as the result of supplementation, the ROS DHA levels remain unchanged, and the prcd disease phenotype is not modified by the dietary manipulation. These findings could be the result of a reduction in the synthesis of DHA-containing phospholipids in the retinas of affected dogs; or, alternatively, there could be a reduction in DHA uptake, transport, or storage within the retinal pigment epithelium-photoreceptor complex.
Article: Lipids of Plasma, Retina, and Retinal Pigment Epithelium in Swedish Briard Dogs with a Slowly Progressive Retinal Dystrophy[Show abstract] [Hide abstract]
ABSTRACT: Reduced blood levels of long chain polyunsaturated fatty acids have been reported in humans and animals with inherited retinal degenerations. The lipid and fatty acid compositions of plasma, retina, and retinal pigment epithelium of the Swedish Briard dog, which has a very slowly progressive retinal dystrophy that is inherited in an autosomal recessive manner were analysed. The lipid class composition of the pigment epithelium was not different between affected and normal dogs; however, significant differences were found between the retinas of the two groups. Affected dogs had relatively more phosphatidylethanolamine and phosphatidylinositol and less phosphatidylcholine than normal dogs. There was no difference in the fatty acid compositions of plasma and retinal pigment epithelium between affected and normal dogs. However, the retinas of affected dogs had significantly lower levels of 22:5n-3 and 22:6n-3 and higher levels of 18:2n-6, 20:4n-6, and 22:5n-6. The total n-3 fatty acid content was significantly lower in affected retinas (P < 0.001), whereas the content of n-6 fatty acids was significantly higher in affected retinas (P < 0.001). These studies provide evidence for yet another animal model of inherited retinal degeneration with a defect in retinal polyunsaturated fatty acid metabolism. The fatty acid pattern in affected dogs resembles that seen in the retina in n-3 fatty acid deficiency.
Article: Plasma Lipid Changes in PRCD-affected and Normal Miniature Poodles Given Oral Supplements of Linseed Oil. Indications for the Involvement of N-3 Fatty Acids in Inherited Retinal Degenerations[Show abstract] [Hide abstract]
ABSTRACT: It has previously been shown that miniature poodles with progressive rod-cone degeneration (PRCD) have lower plasma levels of docosahexaenoic acid (22:6n-3) than normal poodles and it has been suggested that affected animals have a defect in the metabolism of 22:6n-3. To test this hypothesis in vivo, PRCD-affected and normal miniature poodles were given daily oral supplements of linseed oil (enriched in 18:3n-3). Blood was drawn from food-deprived animals at predetermined times before, during and after supplementation, and plasma lipid fatty acids were analysed. There were no differences in the levels of 18:3n-3, 20:5n-3, and 22:5n-3 between affected and normal dogs. Therefore, there appears to be no abnormality in the elongation and desaturation system that takes 18:3n-3 to 22:5n-3. Surprisingly, the plasma level of 22:6n-3 was reduced in both groups following supplementation, but to a significantly greater extent in affected dogs. This resulted in a significantly higher 22:5n-3/22:6n-3 ratio in affected animals. These results support the earlier suggestion of an abnormality in 22:6n-3 metabolism in PRCD-affected miniature poodles. To determine the effect of n-3 supplementation on polyunsaturated fatty acid metabolism in dogs (not as a function of disease), results from both groups of dogs were pooled and compared at times before and near the end of supplementation. Dietary 18:3n-3 led to predictable increases in 18:3n-3, 20:5n-3, and 22:5n-3, but to a decrease in 22:6n-3.(ABSTRACT TRUNCATED AT 250 WORDS)
Article: Lipids of human retina, retinal pigment epithelium, and Bruch's membrane/choroid: Comparison of macular and peripheral regions[Show abstract] [Hide abstract]
ABSTRACT: To understand the difference between macular and peripheral regions, tissue samples of human retina, retinal pigment epithelium, and Bruch's membrane/choroid were dissected and analyzed for lipid composition. To facilitate dissections and enhance the recovery of tissues, eyecups were prefixed for 1 hour in 10% formalin (pH 7). Lipids were extracted from 4-mm trephined punches of tissues and analyzed by high-performance liquid chromatography. After separation of neutral lipids and phospholipids, total fatty acids in both lipid classes were quantitated. The major phospholipid classes in retina, retinal pigment epithelium, and Bruch's membrane/choroid were phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl inositol, and phosphatidyl serine; the major fatty acids were palmitic (16:0), stearic (18:0), and oleic (18:1). Although the three tissues had similar total fatty acid and phospholipid components, their relative compositions were different. Neutral lipid/phospholipid ratios in retinal pigment epithelium and Bruch's membrane/choroid were almost three times higher than in the retina. This study provides information about the lipid composition of macular and peripheral regions of the human retina, retinal pigment epithelium, and Bruch's membrane/choroid. The methodology employed enabled study of lipids in small amounts of tissue, which will be of value in investigating the biochemical aspects of age-related macular degeneration.
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ABSTRACT: The miniature poodle with progressive rod-cone degeneration (prcd) is a model for human retinitis pigmentosa (RP). Since previous studies from several laboratories have shown abnormalities in plasma lipids in human RP, we examined the plasma lipids of prcd-affected animals. Fasting blood was drawn on three separate occasions from affected and control miniature poodles and on one occasion from normal Irish setters and those affected with a different inherited retinal degeneration (rod-cone dysplasia). Plasma phospholipids from prcd-affected animals had significantly lower levels of docosahexaenoic acid (22:6 omega 3) and cholesterol, compared to control miniature poodles. No differences were observed in plasma levels of phospholipids, vitamin E, or vitamin A, and no lipid differences were found between control and affected Irish setters. The ratios of 22:5 omega 3 to 22:6 omega 3 and of 22:4 omega 6 to 22:5 omega 6 were significantly elevated in prcd-affected poodles compared to controls. Since the conversion of 22:5 omega 3 to 22:6 omega 3 and of 22:4 omega 6 to 22:5 omega 6 is catalysed by a delta 4-desaturase, these results are consistent with a defect in desaturase activity in the prcd-affected poodle.
Article: Fatty acid metabolism in normal miniature poodles and those affected with progressive rod-cone degeneration (PRCD)[Show abstract] [Hide abstract]
ABSTRACT: It is possible that a genetic defect observed in the prcd poodle involves the abnormality of an enzyme which functions in phospholipid or lipoprotein metabolism. In our studies thus far, we have been unable to detect any defect in retinal phospholipid biosynthesis, but we have noted a decrease in plasma levels of 22:6w3 which may be a result of an enzyme defect in liver biosynthesis of 22:6w3 from its dietary precursor, linolenic acid, or some defect in the blood lipoprotein transport of this essential fatty acid. If 22:6w3 is essential to the normal elaboration and functioning of the photoreceptor outer segment, it is possible that decreased access to this fatty acid due to lower blood levels of 22:6w3 could cause photoreceptor abnormalities. Further studies are needed to confirm the possible defect in delta-4 desaturase activity and possible dietary modification of the course of this prcd retinal degeneration.
Article: Clinical and Serum Lipid Findings in a Large Family with Autosomal Dominant Retinitis Pigmentosa[Show abstract] [Hide abstract]
ABSTRACT: Retinitis pigmentosa, of unknown cause, has recently been associated with decreased amounts of the polyunsaturated fatty acid, docosahexaenoic acid, in the plasma of affected as compared with unaffected relatives. It has been suggested that this finding may serve as a marker for the disease and might indicate alterations in photoreceptor cell metabolism. The authors studied 54 members of a family with dominantly inherited retinitis pigmentosa in five generations. In addition to the typical clinical findings of retinitis pigmentosa, eight persons also had a bull's eye maculopathy, and four persons had uni- or bilateral optic nerve drusen. When the authors determined the plasma fatty acid and lipid contents, they saw the expected age-related effect on cholesterol and triglycerides, but an unexpected, significant reduction in fatty acids in the unaffected controls as compared with persons with retinitis pigmentosa. The authors' results emphasize the heterogeneity of phenotypic expression of retinitis pigmentosa within a single family.
Article: Abnormal plasma levels of polyunsaturated fatty acid in autosomal dominant retinitis pigmentosa
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ABSTRACT: Oil droplets are observed in the retinal pigment epithelium (RPE) of both light- and dark-adapted rats. The accumulation of these droplets is strongly correlated with the clearance of large phagosomes that are found on a circadian basis in the RPE. Although strongly correlated with phagosomes in this way, the composition of the oil droplets does not resemble the lipid composition of rod outer segments (ROS). The important differences are that most of the 18:0 fatty acid (stearic) and virtually all of the polyunsaturated ones (principally docosahexaenoic, 22:6) are absent from the droplets. The major (greater than 95%) constituents of the droplets are triglycerides admixed with small amounts of vitamin A esters (less than 5%). This result suggests that certain of the ROS lipids, especially the polyunsaturated fatty acids, are cleared quickly from the RPE and are, perhaps, recycled to the neural retina. Such a process would account for the known ability of the retina to conserve the polyunsaturates despite dietary deficiencies.
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ABSTRACT: Previous evidence suggests that lipid peroxidation may initiate photoreceptor damage induced by constant light exposure. In order to investigate the role of the antioxidant vitamin E in light damage, Long-Evans (pigmented) rats were atropinized and exposed to constant fluorescent light (Vita-Lite) of 10-20 foot candles for intervals up to 5 days. Following light exposure, retinal rod outer segments (ROS) were prepared and their lipids extracted. Retinas processed in parallel for morphological examination showed progressive ROS deterioration and selective loss of photoreceptor cells at 3 and 5 days of constant light. Similar to previous observations in undilated albino rats, constant illumination resulted in the specific loss of docosahexaenoic acid (22:6 omega 3) in the ROS. A novel finding in this study was an increase in the content of vitamin E relative to lipid phosphorus, stearic acid, and docosahexaenoic acid in the ROS of constant light-exposed animals.
Top Journals
Baylor College of Medicine
Houston, Texas, United States
- • Department of Pediatrics
- • Cullen Eye Institute
- • Department of Ophthalmology
University of Pennsylvania
Philadelphia, Pennsylvania, United States
- School of Veterinary Medicine
Texas Medical CenterHouston, Texas, United States


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The Conservatives are now the progressive party
A wise and provocative article in today's Guardian by David Marquand. (I am of course using the phrase "wise and provocative" in its secondary, blogging, sense, to mean "he agrees with me".) Marquand takes up two of my favourite themes: that there is nothing progressive about the contemporary British Left; and that David Cameron ought to be inspired by the spirit of the American Revolutionaries - or, at least, of their British allies.
Marquand points out that support for the colonists' cause was one of the only issues that united Edmund Burke and Tom Paine. Actually, it probably united a fair chunk of Britain. Kevin Phillips demonstrated in his great work, The Cousins' Wars, that the population of the mother country differed little in its sympathies from that of the colonies. On both sides of the Atlantic, there was a Tory minority of perhaps 35 or 40 per cent of the population – although in Britain, where there was no universal franchise, that minority dominated Parliament.
The good news is that Cameron does seem to be a radical in the sense that Marquand means: that he wants to disperse power more widely. The day may not be far off when we repatriate our revolution.
Recent Posts
So long and thanks for all the clicks
November 30th, 2014 22:43
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November 28th, 2014 16:00
What does it mean to be conservative?
November 24th, 2014 8:17
Is the democratic Left finally turning against the EU?
November 20th, 2014 12:06
Wrong then, wrong now. Why do we keep listening to the Euro-fanatics?
November 14th, 2014 11:20


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Radiolarian Zonation and Stratigraphy of the Upper Cretaceous Portion of the Great Valley Sequence, California Coast Ranges
AUTHOR: Pessagno, Emile A., Jr.
PUBLISHER: Micropaleontology Project, Incorporated
Also available at Amazon.com
This book is not guaranteed to come with supple-
mental materials (access codes, CD's, DVDs, etc.)
mental materials (access codes, CD's, DVDs, etc.)
21 Day Unconditional Guarantee
any book, any reason


text: Hi - long time lurker, first time poster. My dad has an old Belkin F5D8230-4 Pre-N MIMO router which has been working fairly well for many years, combined with a Netgear WNDR2000 repeater. He has 3 iPads, an 3 iPhone 4S's 1 iPhone 5, and three laptops with Intel 6300 cards in them in use in the house most of the time. He also has a Sony smart TV connected via WiFi. He recently added an AppleTV to a downstairs TV (1 floor directly below the router) and has found that he cannot reliably stream a Netflix or iTunes movie. After the AppleTV was installed he mentioned that his internet has really been quite poor for about 1 year. I used inSSIDer to verify that he has good signal strength and that there are not many other devices infringing on his frequency. Just to be safe I switched his stuff from channel 6 to channel 11. His house is about 6,000 sq. ft under air and is on a couple acre waterfront lot - no other networks were in range with a signal above about -86dbm. If I connect directly to his comcast modem I get consistent 25mbps downloads and about 4mbps up. Through the wireless with only one client attached I get about 2mbps down and almost no upstream speed. It used to be the same as a direct connection to the modem. I have a Linksys E4200 that has been fairly stable, but it slows down occasionally on the 2.4ghz side which can be fixed by going into the router utility and deleting any single client DHCP reservation - about once every few months. I see a lot of love for the ASUS routers, but I don't know if the people using them are more tech savvy that don't mind being on the bleeding edge of technology, or if they are truly better than the current Linksys stuff. I have had bad prior experience with Netgear routers that keeps them off my list. I see a lot of good reviews for ASUS, but there seem to be a lot of firmware issues. I see a lot of disdain for Linksys, but I wonder if the expectations are higher from non-techy people with the linksys gear. Apple gets no love... I am going to put my E4200 in his house temporarily to see if it solves the problem, but ultimately I want to have a 5ghz network set up for the TV's and maybe the iPad 3s, and a 2.4ghz network for everything else - basically that is how I have my house set up. My options as I see them: Asus RT-N66U or AC66U - concerns - long term stability - there will be no ability to reset or update firmware once installed. Linksys EA4500 or 6500. I don't know which is better, same restrictions apply as to no resets or firmware updates allowed once installed. The EA4500 is appealing because it is essentially the same as what I have, which I know works acceptably (it could be better) Apple Airport Extreme - the advantage I see with this one is that I know a few people who have them and they say it is truly set it and forget it. I am sure the range would be lower than the others - this may be an issue. Ideally I would like to get rid of the range extender. The Belkin router he is running now literally had not been power cycled in 5+ years up until we connected the AppleTV - I can't put something in that is less reliable. Thoughts - other recommendations?


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Individual Donations
Enable local artists to export their talent
Our Quebec creativity and talent shine brightly on the world's great stages… This is our pride. Get in on the act by donating, to allow our art and culture to continue to shine!
Our concrete actions
- The Atelier lyrique produces the stars of tomorrow by providing the training required for home-grown talent to blossom. Donate to encourage the emergence of opera talent.
- Support the creation of Quebec repertoire, such as Les feluettes, a major theatrical work from Quebec being given its world premiere as an opera, with staging by Serge Denoncourt. Drama set to music at its most daring! Donate to stimulate Quebec creativity!
- New productions and co-productions: Elektra, with set design by Spanish sculptor Victor Ochoa, or Otello (co-produced with Pacific Opera Victoria) and other international collaborations. Donate to get intimately involved in furthering our international reach.
- Our craftspeople, our heritage: a workshop with over 4,000 costumes, some twenty sets, unique know-how that is 100% Québécois… Your donation contributes to building our cultural heritage and to enhancing our savoir-faire.
- Opera America: Montreal at the heart of our reflections on opera, for the first time in Quebec.
Give Mathieu a chance to experience his first opera
Mathieu has never seen an opera. Give him the chance to experience his first opera, like over 7,000 other young people do each year, thanks to the Opéra de Montréal's free educational efforts. For we know that an appreciation of opera is developed early on, that young people are our audience of tomorrow, and that art has a major impact on personal development and contributes to academic success. The Opéra de Montréal is relying on your donations so that these projects can continue to enthral the new generation of opera fans.
- Student rehearsals: each year, 7,000 young people are introduced to opera—free of charge—via student rehearsals. It's their first contact, but never their last!
- School matinee: to give 10 to 12 year-olds a taste of the art form by raising their awareness of opera, its history, its professions, and its music.
- coOpera: to enable 90 young people from disadvantaged backgrounds to produce their own musical performance based on a work presented at the OdM. Art as a source of hope, ethnic integration, academic success, teamwork, and efforts rewarded…
- Interactive workshop and exhibition in the school milieu: to introduce everyone to opera and stimulate a taste for discovery…
Did you know there are various ways to support Opéra de Montréal? You can make a donation:
- when renewing your subscription;
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A few of your privileges:
- Receipt for tax purposes
- Invitation to attend Atelier lyrique activities
- Free parking
- A backstage tour
- And more
For additional information, please contact Monique Denis, Donations and Sponsorships Manager, at 514.985.2222, extension 2221 or at firstname.lastname@example.com


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The Queen visited St Margaret's Hospice in Clydebank last year. It has now been highly praised by healthcare inspectors
Caroline Wilson, Senior Reporter / / News
A HOSPICE which faced critical funding threats has been given a landmark care grading.
St Margaret of Scotland Hospice in Clydebank has been awarded five "excellent" ratings by Healthcare Improvement Scotland.
It is the first time the inspectors have given an independent hospice such a high rating with no recommendations for improvement.
The 58-bed hospice, Scotland's oldest and largest, was given the top rating in quality of care, environment, staff, management and information for patients and relatives.
Inspectors praised staff for involving patients and relatives in care plans and said workers spoke with "pride and passion" about the hospice.
Wards were described as "spacious, comfort-able and well main-tained". Comments from patients included, "Staff are totally dedicated to their patients. Physical and emotional wellbeing has been met in an exceptional way."
The hospice provides 30 specialist palliative care places and 28 continuing care beds as well as an outpatient service.
Last year, it was visited by the Queen.
Patients have access to a quiet lounge area, a prayer room, spa, therapy rooms, and there is accommodation for families.
The report states: "We found that people who used St Margaret of Scotland Hospice were complimentary about the service provided.
Promoted stories
"People who used the service and their families were involved in identifying care needs and how they would like their care to be given.
"Staff were motivated and spoke with pride and passion about working in the hospice."
It comes after a difficult few years for the hospice which faced losing £1.2million of annual NHS funding for 30 continuing care beds.
NHS Greater Glasgow and Clyde was forced to make a U-turn following a long-running campaign by patients and relatives.
However campaigners claim the hospice still receives around 40% of the funding per bed which other hospices receive within the health board area.
Professor Leo Martin, chairman of the hospice's board of directors, said: "The findings of Healthcare Improvement Scotland are not a surprise to anyone who has been touched by St Margaret of Scotland Hospice.
"The findings reinforce the excellent management at the hospice and dedication of all of our staff."
Jean Anne Mitchell, who has direct experience with the hospice, has raised a petition calling for increased funding.
She said: "I believe that a comparison of funding shows that St Margaret of Scotland Hospice receives substantially less funding than the sector average.
"This requires to be addressed."
caroline.wilson@ eveningtimes.co.uk
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Recalls and TSBs » Volvo Recall » Xc70 » 2006
2006 Volvo Xc70 Recalls
Be aware of recent 2006 Volvo Xc70 recalls to always be safe on the road.
Recent 2006 Volvo Xc70
2006 Volvo Xc70 Equipment Recall 10V566000
Campaign Number: 10V566000
Date Manufactured: Nov 16, 2010
Vehicles Affected: 416
Manufacturer: Volvo Cars Of N.a. Llc.
Mfr's Report Date: Nov 08, 2010
Component: Equipment
2006 Volvo Xc70 Service Brakes, Hydraulic Recall 07E023000
Campaign Number: 07E023000
Date Manufactured: Mar 29, 2007
Vehicles Affected: 13128
Manufacturer: Cardone Industries, Inc.
Mfr's Report Date: Mar 29, 2007
Component: Service Brakes, Hydraulic


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I'm using IG 9.2's support for export to Excel. I would like to exclude a couple of columns from being exported to Excel. Can you let me know how that could be done?
Hello Joe,
The easiest way I found is to register for the EndExport event and simply manipulate the Excel Workbook form there. E.g:
e.Workbook.Worksheets[0].Columns[0].Hidden =
e.Workbook.Worksheets[0].Columns[0].Hidden =
Hope this helps.
Petar Monov,
DS Engineer,
Infragistics Bulgaria
Petar Monov,
DS Engineer,
Infragistics Bulgaria
Sincerely, Petar, MCTS Software Developer Infragistics www.infragistics.com\support
Thanks Petar but this may not work for me as the column still exists in the Excel. My users need the excel to feed into another system or save as csv where this column would still show.
When handling the InitializeRecord event the InitializeRecordEventArgs has a SkipRecord property. Isnt there something similar for columns ?
Hi Joe,
In that case you can register for the HeaderLabelExporting and CellExporting events and use something like this to prevent the exporting:
if (e.CurrentColumnIndex == 1)
e.Cancel = true;
Regards Petar.
Thanks Petar. This way the label and the column data doesn't get exported but I still have the problem that there is an empty column in the exported Excel. Saving the file to csv for eg will add a redundant comma to the csv for the empty column.
For now I've worked around by:
* removing the concrened columns fromthe layout (setting field.Visibility = Visibility.Collapsed)
* Exporting
* setting visibility back to Visible
Would it be possible for you to raise this as a request for a future release? Similar to how you have SkipRecord
We are using 2009.2. and would like to know if customizing Excel Export to "exclude" columns is available in this or any future version. Meaning, out of 5 columns displayed in the grid we would like to export only 3 columns.
Or is it possible to put in a feature request to facilitate the same.
Thanks in advance.
Any comments? Thanks.
was this enhanced somehow in last 5 years? I'm using version 2013.2 and it seems like even hiding column in the resulting worksheet doesn't work.
Hello Anton,
Thank you for your post. I have been looking into it and I can suggest you handle the DataPresenterExcelExporter's ExportSatrted event. This event will pass you a clone of the XamDataGrid. Which is used for the exporting. Since it's a clone, you can make changes to this layout and it will not affect the on-screen grid, only the export. So you can hide fields or layouts, change colors, or anything else you like. I also created sample project for you showing this approach. Please let me know if this helps you or you have further questions on this matter.
Looking forward for your reply.
Sincerely, Stefan, MCPD Software Developer Infragistics, Inc. www.infragistics.com/support
Thanks, Stefan! That is exactly what I was looking for. I've extended your solution by creating attached property ExcludeFromExport for the Field, so now I'm not dependent on field names and I can mark fields to exclude from export directly in xaml.


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Looks like you are using an old version of Internet Explorer - Please update your browser
The first of a series of three advertisements appeared in yesterday's largest U.S. newspaper to announce the launch of the "I am not ashamed" campaign. We have had previous blog posts and articles about this campaign on our website. The concept is to let the Bible speak for itself and call on Christians in America to be more bold in standing up for God's Word. The advertisement yesterday read:
The Bible speaks for itself on marriage—God made them male and female, Mark 10:6.People were then directed to the www.iamnotashamed.org website. Today's advertisement deals with abortion—get your copy of USA Today and see how boldly and unashamedly we are quoting God's Word publicly in dealing with this moral issues. On Wednesday, the advertisement deals with the state of the nation.
Also yesterday, we launched television advertisements on the Fox News channel. These advertisements show a number of people stating they are not ashamed of the gospel and not ashamed of the Word of God and encourages them to become a part of the world's first online video Bible. Then people are directed to the www.iamnotashamed.org website. On the website, you will be instructed on how you can be one of 8,000 people reading four verses of Scripture to produce the world's first online video Bible. Anyone can do this from anywhere in the world.
We are also releasing a series of billboards that a growing number of people and churches are sponsoring. These billboards deal with five topics: marriage, abortion, racism, the state of the nation, and creation. There will also be advertisements placed in various magazines. You can also sponsor the various advertisements in your local newspaper etc.
One church from the Atlanta, Georgia, area recently decided to sponsor the five billboards, exhibiting each one for three months consecutively—that means they will be unashamedly quoting God's Word in public like this for 15 months!
The "I am not ashamed" campaign is just gearing up! We urge you to be a part of it and support this powerful venture—to let God's Word speak for itself across the nation and encourage more and more of God's people to unashamedly and publicly stand on the authority of the Word of God.
Nanotech Could Make Humans Immortal by 2040, Futurist SaysThe article then stated:
In 30 or 40 years, we'll have microscopic machines traveling through our bodies, repairing damaged cells and organs, effectively wiping out diseases. The nanotechnology will also be used to back up our memories and personalities.Now, notice in the text of the article, the person being interviewed said "close to immortal." He is certainly not game to make the statement the headline does!
In an interview with Computerworld, author and futurist Ray Kurzweil said that anyone alive come 2040 or 2050 could be close to immortal. The quickening advance of nanotechnology means that the human condition will shift into more of a collaboration of man and machine, as nanobots flow through human blood streams and eventually even replace biological blood, he added.
That may sound like something out of a sci-fi movie, but Kurzweil, a member of the Inventor's Hall of Fame and a recipient of the National Medal of Technology, says that research well underway today is leading to a time when a combination of nanotechnology and biotechnology will wipe out cancer, Alzheimer's disease, obesity and diabetes.
However, regardless, I can categorically state that man will never be able to use technology to make humans immortal—never. How can I be so absolutely sure?
God's Word makes it clear in Genesis that because of our rebellion (sin) in Adam, we are all subject to the death penalty:
. . . but of the tree of the knowledge of good and evil you shall not eat, for in the day that you eat of it you shall surely die (Genesis 2:17).
In the sweat of your face you shall eat bread till you return to the ground, for out of it you were taken; for dust you are, and to dust you shall return (Genesis 3:19).
Therefore, just as through one man sin entered the world, and death through sin, and thus death spread to all men, because all sinned (Romans 5:12).
And as it is appointed for men to die once, but after this the judgment (Hebrews 9:27).There are, of course, many other such Scriptures in whiche the Bible makes it clear that every human being will die (unless the Lord returns before that time). God's Word also makes it clear there will be death until the Lord returns and makes a new heavens and a new earth. We are warned about a "second death," which is eternal separation from God:
Revelation 2:11—He who has an ear, let him hear what the Spirit says to the churches. He who overcomes shall not be hurt by the second death.Back in the Garden, when the serpent tempted Adam and Eve, the temptation was that they "could be as gods." In other words, they could be their own "god." Ever since, man has been trying to act as god—and we see that even today as frail, fallible, sinful, finite humans think they can make themselves immortal in these physical bodies. Yes, all humans will live forever, but either with God or separated from Him.
Revelation 20:6—Blessed and holy is he who has part in the first resurrection. Over such the second death has no power.
Revelation 20:14—Then Death and Hades were cast into the lake of fire. This is the second death.
Revelation 21:8—But the cowardly, unbelieving, abominable, murderers, sexually immoral, sorcerers, idolaters, and all liars shall have their part in the lake which burns with fire and brimstone, which is the second death.
Try as they may, humans will never ever be able to construct technology that will result in humans becoming immortal. I can state this with conviction because God's Word categorically denies it could ever happen.
You can read the entire article about this nanotechnology claim.
I have included a photograph I took inside the Opryland Resort and Convention Center where the NRB convention is being held:
ChangesThanks for stopping by and thanks for praying, Ken
(Psalm 55:19) Because they have no changes, therefore they fear not God.
Our first reaction is to resent the changes in our life of predictable constancy, but those changes cast us on the Lord Jesus Christ and cause us to see His power
Answers in Genesis is an apologetics ministry, dedicated to helping Christians defend their faith and proclaim the gospel of Jesus Christ.


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[edit] Background
Ring II is the story of Siegfried, Siegmund and Sieglinde's son, and tells of how he was the one who found and conquered the Ring before saving Brunehilde. And then, by betraying her, how he caused the fall of the Gods' reign, so that the Time of Human may rise. The particularity of Ring II is not to have considered Wagner's operas as unique sources of inspiration, but to have also looked for story materials in some very ancient versions of the legend as Thydrek of Verona or Horny skin Seyfried's saga, as well as directly from the Eddas itself. With Siegfried's childhood itself under the microscope of the player, the character's destiny entwines those who control it, and play an active role in seeing his growth into the hero he is destined to become.
[edit] Features
- Adventure game based on Wagner's operas "Siegfried" and "Twilight of the Gods" and sequel to the super-bestseller Ring: The Legend of the Nibelungen.
- Storyline based on the Scandinavian mythology that inspired J.R.R. Tolkien to create the world famous epic "Lord of the Rings".
- Modern CINERGY engine: 3D characters and real-time rendered visual effects are combined with highly-detailed high-resolution backgrounds.
- 30 minutes of spectacular animated cutscenes.
- Comfortable interface allowing the player to fully concentrate on the storyline.


text:
tag: inlay
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Curved desk in ash and walnut5 comments
Curved top desk in ash and walnut. Top is ash with walnut inlay strip. Legs are bent laminations of walnut. Stretcher is also bent lamination to match curve of top. I built this for a...view details
Broncos table
This solid maple and walnut inlay table uses mortise and tendon joinery. The maple is ambrosia maple cut from a 12 foot 8/4 slab.I went for a floating top design similar to ones seen in this...view details
Oak Leaf Theme, Dining Table7 comments
The theme of this dining table is based on the fall season with oak leaves and acorns. The table size is 31" tall x 51" wide x 93"long. Designing and making this table took me a little over 1800...view details
Tack Trunk2 comments
This tack trunk was designed and crafted by Sean Bell of Board Foot, Inc. in Burlington, New Jersey. It was a gift for our daughter who is an aspiring equestrian. We had ask Sean to make a...view details
Trestle Dining Table with Pullout Leafs
The table was designed based on a picture she had from a department store. I added the pull out leaf feature after seeing the article of Tommy MacDonald's table. The difficult part was designing the...view details
Nolan's Hanging Wall Cupboard2 comments
This project was intended to be a progression in my use and interpretation of the Art Nouveau style. While much smaller in scale than Mairead's Bookcase, this cupboard shares the same layering of...view details
Hufschmid 'H6 TANTALUM' project!
I started building this one of a kind 'Hufschmid Guitars 19th anniversary creation' a year ago as a side project!The body is inspired by a great classic (my own take on it), the headstock is my own...view details
Coffee Table1 comment
Construction was of Walnut with Bloodwood inlays. I used Craftsman design elements (cloudlift aprons) along with a floating top to give it a sense of lightness. The finish is french polished...view details
Corset Dining Table - Taylor Donsker1 comment
We are lucky to work with such stunning slabs of live edge California Claro Walnut. Being that we are also located in California, we have access to the most stunning and properly kiln dried slabs...view details
Woodworking Business - What To Build To Make Profits2 comments
Woodworking is a great art and hobby that you can quickly turn into business. You need to know that different woodwork projects will have different markets. For instance, if you are making toys, then...view details
Inlayed MesquiteTable1 comment
Pieced together from remenants of previous projects, this small table features sculpted live edges and turquoise inlay. The apron pieces beneath the floating top are fabricated from bent wood...view details
Persian Armoire1 comment
Solid walnut persian style armoire. The doors are two bookmatched slabs with crushed turquise and brass powder inlayed into knots. The three towers on each side draw inspiration from middle...view details
Figured Hall Table1 comment
This piece is a shaker inspired hall table made of figured makore and tiger maple. Includes simple router based inlay which adds a decorative flare to a classic style piece while delivering on...view details
Hufschmid H6 - Salvaged Flame Maple Top!
A new guitar I just completed for a customer. This unique creation features a very gorgeous Highly Figured Salvaged maple top which I've stained with my unique 'Helldunkel stain', West African Ebony...view details
Line & Berry Jewlery Box2 comments
This jewelry box was designed using AutoCad. It is made from Walnut with inlay materials of Holly, Cherry, Maple, Redheart and African walnut. The base is a full Ogee cut with a shaper and with...view details
The last workbench I will ever build2 comments
Like many others, I felt it was time for a workbench upgrade, likely this would be the last bench I build and wanted it to be unique. The design is my own, incorporating many features from my...view details
Hall Table2 comments
The top is ancient reclaimed redwood, with a white oak inlay. The base is reclaimed white oak from a large wine cask. The inlay was inspired by Scott Lewis' curvy cutting board. The legs were...view details
Modern Waterbed
This is a Waterbed that I built for someone. They designed the bed using sketchup and sent me the picture. I used oak with Walnut accents. The drawers I did an inlay look by just gluing the...view details
Hufschmid Guitars H6 - Glow in the dark 'HufGlow' block inlays!
A new guitar I just completed for a customer. This unique creation features a gorgeous one piece premium quatersawn 'Sapelli Mahogany' body and neck, the fingerboard is west african ebony!view details
Cherry Sideboard
This is a cherry sideboard sized to fit in our laundry room. The black inlay highligting in the legs, door fronts and top is Macassar Ebonyview details
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El Burrito Mercado
Burritos aren't Mexican. Tacos are Mexican. Burritos are tacos by way of California super-growth-hormone, and so the best places for burritos in town are not necessarily the best places for that oft-cited Holy Grail, "authentic Mexican food." What are the best places for burritos? Glad to spill the beans, and they are, in no particular order, Edina's Tejas, Uptown's Bar Abilene, downtown Minneapolis's two El Burrito restaurants (no relation to El Burrito Mercado), Hudson, Wisconsin's San Pedro Café, and the many Chipotle grills. A good burrito depends on having a really flavorful (actually over-flavored) filling, so that by the time it melds with rice, beans, tomatoes, cheese, a 12-inch flour tortilla, and whatever the heck else you throw in there, it still tastes like something. On a recent visit to El Burrito Mercado--king of the hill, and the one to beat--the stews they were ladling into their plump, $3.50 gems didn't just taste like something, they tasted like wow. Beef in a red-chile stew stung beautifully, pork in tomatillo sauce was brisk, chicken and corn was sweet and cinnamon-touched. That El Burrito Mercado is distinctly authentic is only gilt on the lily, as was a $1 fresh pineapple drink, made pretty with square-cut chunks of fruit floating in the glass.
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