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Publications (57)317.81 Total impact
Article: Quillaja saponin variants with central glycosidic linkage modifications exhibit distinct conformations and adjuvant activities[Show abstract] [Hide abstract]
ABSTRACT: Immunological adjuvants such as the saponin natural product QS-21 help stimulate the immune response to co-administered antigens and have become increasingly important in the development of prophylactic and therapeutic vaccines. However, clinical use of QS-21 is encumbered by chemical instability, dose-limiting toxicity, and low-yielding purification from the natural source. Previous studies of structure–activity relationships in the four structural domains of QS-21 have led to simplified, chemically stable variants that retain potent adjuvant activity and low toxicity in mouse vaccination models. However, modification of the central glycosyl ester linkage has not yet been explored. Herein, we describe the design, synthesis, immunologic evaluation, and molecular dynamics analysis of a series of novel QS-21 variants with different linker lengths, stereochemistry, and flexibility to investigate the role of this linkage in saponin adjuvant activity and conformation. Despite relatively conservative structural modifications, these variants exhibit striking differences in in vivo adjuvant activity that correlate with specific conformational preferences. These results highlight the junction of the triterpene and linear oligosaccharide domains as playing a critical role in the immunoadjuvant activity of the Quillaja saponins and also suggest a mechanism of action involving interaction with a discrete macromolecular target, in contrast to the non-specific mechanisms of emulsion-based adjuvants.
Article: Design, synthesis, and immunologic evaluation of vaccine adjuvant conjugates based on QS-21 and tucaresol[Show abstract] [Hide abstract]
ABSTRACT: Immunoadjuvants are used to potentiate the activity of modern subunit vaccines that are based on molecular antigens. An emerging approach involves the combination of multiple adjuvants in a single formulation to achieve optimal vaccine efficacy. Herein, to investigate such potential synergies, we synthesized novel adjuvant conjugates based on the saponin natural product QS-21 and the aldehyde tucaresol via chemoselective acylation of an amine at the terminus of the acyl chain domain in QS saponin variants. In a preclinical mouse vaccination model, these QS saponin-tucaresol conjugates induced antibody responses similar to or slightly higher than those generated with related QS saponin variants lacking the tucaresol motif. The conjugates retained potent adjuvant activity, low toxicity, and improved activity-toxicity profiles relative to QS-21 itself and induced IgG subclass profiles similar to those of QS-21, indicative of both Th1 cellular and Th2 humoral immune responses. This study opens the door to installation of other substituents at the terminus of the acyl chain domain to develop additional QS saponin conjugates with desirable immunologic properties.
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ABSTRACT: Adjuvants are materials added to vaccines to enhance the immunological response to an antigen. QS-21 is a natural product adjuvant under investigation in numerous vaccine clinical trials, but its use is constrained by scarcity, toxicity, instability and an enigmatic molecular mechanism of action. Herein we describe the development of a minimal QS-21 analogue that decouples adjuvant activity from toxicity and provides a powerful platform for mechanistic investigations. We found that the entire branched trisaccharide domain of QS-21 is dispensable for adjuvant activity and that the C4-aldehyde substituent, previously proposed to bind covalently to an unknown cellular target, is also not required. Biodistribution studies revealed that active adjuvants were retained preferentially at the injection site and the nearest draining lymph nodes compared with the attenuated variants. Overall, these studies have yielded critical insights into saponin structure-function relationships, provided practical synthetic access to non-toxic adjuvants, and established a platform for detailed mechanistic studies.
Article: Phase I Trial of a Bivalent Gangliosides Vaccine in Combination with -Glucan for High-Risk Neuroblastoma in Second or Later Remission[Show abstract] [Hide abstract]
ABSTRACT: Purpose: To report on a phase I trial designed to find the maximally tolerated dose in children of the immunologic adjuvant OPT-821 in a vaccine containing neuroblastoma-associated antigens (GD2 and GD3; Clinicaltrials.gov NCT00911560). Secondary objectives were to obtain preliminary data on immune response and activity against minimal residual disease (MRD). Treatment also included the immunostimulant β-glucan. Experimental design: Patients with neuroblastoma in ≥2nd complete/very good partial remission received vaccine subcutaneously (weeks 1-2-3-8-20-32-52). Vaccine contained 30 μg each of GD2 and GD3 stabilized as lactones and conjugated to the immunologic carrier protein keyhole limpet hemocyanin; and OPT-821, which was dose escalated as 50, 75, 100, and 150 μg/m(2) per injection. Oral β-glucan (40 mg/kg/day, 14 days on/14 days off) started week 6. Results: The study was completed with 15 patients because there was no dose-limiting toxicity at 150 μg/m(2) of OPT-821 (the dosing used in adults). Thirteen of fifteen patients received the entire protocol treatment, including 12 who remain relapse-free at 24+ to 39+ (median 32+) months and 1 who relapsed (single node) at 21 months. Relapse-free survival was 80% ± 10% at 24 months. Vaccine and β-glucan were well tolerated. Twelve of fifteen patients had antibody responses against GD2 and/or GD3. Disappearance of MRD was documented in 6 of 10 patients assessable for response. Conclusions: This immunotherapy program lacks major toxicity and is transportable to any outpatient clinic. Patient outcome is encouraging but the efficacy is uncertain because of the complexity and heterogeneity of prior therapies. A larger phase II trial is underway.
Article: Applying PET to Broaden the Diagnostic Utility of the Clinically Validated CA19.9 Serum Biomarker for Oncology[Show abstract] [Hide abstract]
ABSTRACT: Despite their considerable advantages, many circulating biomarkers have well-documented limitations. One prominent shortcoming in oncology is a high frequency of false-positive indications for malignant disease in upfront diagnosis. Because one common cause of false positivism is biomarker production from benign disorders in unrelated host tissues, we hypothesized that probing the sites of biomarker secretion with an imaging tool could be a broadly useful strategy to deconvolute the meaning of foreboding but inconclusive circulating biomarker levels. In preparation to address this hypothesis clinically, we developed (89)Zr-5B1, a fully human, antibody-based radiotracer targeting tumor-associated CA19.9 in the preclinical setting. (89)Zr-5B1 localized to multiple tumor models representing diseases with undetectable and supraphysiologic serum CA19.9 levels. Among these, (89)Zr-5B1 detected orthotopic models of pancreatic ductal adenocarcinoma, an elusive cancer for which the serum assay is measured in humans but with limited specificity in part because of the frequency of CA19.9 secretion from benign hepatic pathologies. In this report, a general strategy to supplement some of the shortcomings of otherwise highly useful circulating biomarkers with immunoPET is described. To expedite the clinical validation of this model, a human monoclonal antibody to CA19.9 (a highly visible but partially flawed serum biomarker for several cancers) was radiolabeled and evaluated, and the compelling preclinical evidence suggests that the radiotracer may enhance the fidelity of diagnosis and staging of pancreatic ductal adenocarcinoma, a notoriously occult cancer.
Article: Accelerated Tumor Growth Mediated by Sublytic Levels of Antibody-Induced Complement Activation Is Associated with Activation of the PI3K/AKT Survival Pathway[Show abstract] [Hide abstract]
ABSTRACT: We addressed the possibility that low levels of tumor cell bound antibodies targeting gangliosides might accelerate tumor-growth. To test this hypothesis, we treated mice with a range of mAb doses against GM2,GD2,GD3 and CD20 after challenge with tumors expressing these antigens and tested the activity of the same mAbs in-vitro and the mechanisms behind the complement-mediated tumor growth acceleration that we observed and an approach to overcome it. Serologically detectable levels of IgM-mAb against GM2 are able to delay or prevent tumor growth of high GM2-expressing-cell-lines both in-vitro and in a SCID mouse model, while very low levels of this mAb resulted in slight but consistent acceleration of tumor growth in both settings. Surprisingly, this is not restricted to IgM-antibodies targeting GM2 but consistent against IgG-mAb targeting GD3 as well. These findings were mirrored by in-vitro studies with antibodies against these antigens as well as GD2 and CD20 (Rituxan), and shown to be complement-dependent in all cases. Complement-mediated-accelerated-growth of cultured tumor cell-lines initiated by low mAb levels was associated with activation of the PI3K/AKT survival pathway and significantly elevated levels of both p-AKT and p-PRAS40. This complement-mediated PI3K-activation and accelerated tumor growth in-vitro and in-vivo are eliminated by PI3K-inhibitors NVP-BEZ235 and Wortmannin which also significantly increased efficacy of high doses of these 4 mAbs. Our findings suggest that manipulation of the PI3K/AKT pathway and its signaling network can significantly increase the potency of passively administered mAbs and vaccine-induced-antibodies targeting a variety of tumor-cell-surface-antigens.
Article: Synthesis and Preclinical Evaluation of QS-21 Variants Leading to Simplified Vaccine Adjuvants and Mechanistic Probes[Show abstract] [Hide abstract]
ABSTRACT: QS-21 is a potent immunostimulatory saponin that is currently under clinical investigation as an adjuvant in various vaccines to treat infectious diseases, cancers, and cognitive disorders. Herein, we report the design, synthesis, and preclinical evaluation of simplified QS-21 congeners to define key structural features that are critical for adjuvant activity. Truncation of the linear tetrasaccharide domain revealed that a trisaccharide variant is equipotent to QS-21, while the corresponding disaccharide and monosaccharide congeners are more toxic and less potent, respectively. Modification of the acyl chain domain in the trisaccharide series revealed that a terminal carboxylic acid is well-tolerated while a terminal amine results in reduced adjuvant activity. Acylation of the terminal amine can, in some cases, restore adjuvant activity and enables the synthesis of fluorescently labeled QS-21 variants. Cellular studies with these probes revealed that, contrary to conventional wisdom, the most highly adjuvant active of these fluorescently labeled saponins does not simply associate with the plasma membrane, but rather is internalized by dendritic cells.
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ABSTRACT: Mucin glycoproteins present a complex structural landscape arising from the multiplicity of glycosylation patterns afforded by their numerous serine and threonine glycosylation sites, often in clusters, and with variations in respective glycans. To explore the structural complexities in such glycoconjugates, we used NMR to systematically analyze the conformational effects of glycosylation density within a cluster of sites. This allows correlation with molecular recognition through analysis of interactions between these and other glycopeptides, with antibodies, lectins, and sera, using a glycopeptide microarray. Selective antibody interactions with discrete conformational elements, reflecting aspects of the peptide and disposition of GalNAc residues, are observed. Our results help bridge the gap between conformational properties and molecular recognition of these molecules, with implications for their physiological roles. Features of the native mucin motifs impact their relative immunogenicity and are accurately encoded in the antibody binding site, with the conformational integrity being preserved in isolated glycopeptides, as reflected in the antibody binding profile to array components.
Article: Immunization with N-propionyl polysialic acid–KLH conjugate in patients with small cell lung cancer is safe and induces IgM antibodies reactive with SCLC cells and bactericidal against group B meningococci[Show abstract] [Hide abstract]
ABSTRACT: Polysialic acid (polySA) is a polymer side chain bound to the neural cell adhesion molecule that is extensively expressed on the surface of small cell lung cancer (SCLC) cells. In our previous study, a robust antibody response was noted in patients with SCLC after vaccination with 30 μg of keyhole limpet hemocyanin (KLH)-conjugated N-propionylated (NP-) polySA, but peripheral neuropathy and ataxia were detected in several vaccinated patients. The objectives of the current trial were to establish the lowest optimal dose and to confirm the safety of the induction of antibodies against polySA with the NP-polySA vaccine. Patients with SCLC who completed initial treatment and had no evidence of disease progression were injected with either 10 or 3 μg of NP-polySA conjugated to KLH and mixed with 100 μg of immunologic adjuvant (QS-21) at weeks 1, 2, 3, 4, 8, and 16. Nine patients were enrolled at each of the two dose levels. Prior to vaccination, one patient in each group had low-titer antibodies against polysialic acid. All patients at the 10 μg vaccine dose level responded to vaccination with IgM antibody titers against polysialic acid (median titer 1/1,280 by ELISA), and all but one patient made IgM and IgG antibodies against the artificial vaccine immunogen, NP-polysialic acid (median titer 1/10,240). The antibody responses at the 3 μg vaccine dose level were lower; six of nine patients developed antibodies against polysialic acid (median titer 1/160). Post-vaccination sera from 6/9 and 3/9 patients in the 10 and 3 μg groups reacted strongly with human SCLC cells by fluorescent-activated cell sorting (FACS). Sera from all patients in the 10 μg dose group also had bactericidal activity against group B meningococci with rabbit complement. Self-limited grade 3 ataxia of unclear etiology was seen in 1 of 18 patients. Vaccination with NP-polySA-KLH resulted in consistent high-titer antibody responses, with the 10 μg dose significantly more immunogenic than the 3 μg dose. This study establishes the lowest optimally immunogenic dose of NP-polysialic acid in this NP-polysialic acid-KLH conjugate vaccine to be at least 10 μg, and it establishes the vaccine's safety. We plan to incorporate NP-polySA into a polyvalent vaccine against SCLC with four glycolipid antigens also widely expressed in SCLC-GD2, GD3, fucosylated GM1, and globo H.
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ABSTRACT: Evidence indicates that Bax functions as a "lipidic" pore to regulate mitochondrial outer membrane permeabilization (MOMP), the apoptosis commitment step, through unknown membrane elements. Here we show mitochondrial ceramide elevation facilitates MOMP-mediated cytochrome c release in HeLa cells by generating a previously-unrecognized mitochondrial ceramide-rich macrodomain (MCRM), which we visualize and isolate, into which Bax integrates. MCRMs, virtually non-existent in resting cells, form upon irradiation coupled to ceramide synthase-mediated ceramide elevation, optimizing Bax insertion/oligomerization and MOMP. MCRMs are detected by confocal microscopy in intact HeLa cells and isolated biophysically as a light membrane fraction from HeLa cell lysates. Inhibiting ceramide generation using a well-defined natural ceramide synthase inhibitor, Fumonisin B1, prevented radiation-induced Bax insertion, oligomerization and MOMP. MCRM deconstruction using purified mouse hepatic mitochondria revealed ceramide alone is non-apoptogenic. Rather Bax integrates into MCRMs, oligomerizing therein, conferring 1-2 log enhanced cytochrome c release. Consistent with this mechanism, MCRM Bax isolates as high molecular weight "pore-forming" oligomers, while non-MCRM membrane contains exclusively MOMP-incompatible monomeric Bax. Our recent studies in the C. elegans germline indicate that mitochondrial ceramide generation is obligate for radiation-induced apoptosis, although a mechanism for ceramide action was not delineated. Here we demonstrate that ceramide, generated in the mitochondrial outer membrane of mammalian cells upon irradiation, forms a platform into which Bax inserts, oligomerizes and functionalizes as a pore. We posit conceptualization of ceramide as a membrane-based stress calibrator, driving membrane macrodomain organization, which in mitochondria regulates intensity of Bax-induced MOMP, and is pharmacologically tractable in vitro and in vivo.
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ABSTRACT: Four randomized phase III trials conducted recently in melanoma patients in the adjuvant setting have been based in part on the correlation between antibody responses in immunized patients and improved survival. Each of these randomized trials demonstrated no clinical benefit, although again there was a significant correlation between antibody response after vaccination and disease free and overall survival. To better understand this paradox, we established a surgical adjuvant model targeting GD2 ganglioside on EL4 lymphoma cells injected into the foot pad followed by amputation at variable intervals. Our findings are (1) comparable strong therapeutic benefit resulted from treatment of mice after amputation with a GD2-KLH conjugate vaccine or with anti-GD2 monoclonal antibody 3F8. (2) The strongest correlation was between antibody induction in response to vaccination and prolonged survival. (3) Antibody titers in response to vaccination in tumor challenged mice as compared to unchallenged mice were far lower despite the absence of detectable recurrences at the time. (4) The half life of administered 3F8 monoclonal antibody (but not control antibody) in challenged mice administered was significantly shorter than the half life of 3F8 antibody in unchallenged controls. The correlation between vaccine-induced antibody titers and prolonged survival may reflect, at least in part, increased tumor burden in antibody-negative mice. Absorption of vaccine-induced antibodies by increased, although not detected tumor burden may also explain the correlation between vaccine-induced antibody titers and survival in the adjuvant clinical trials described above.
Article: Natural and synthetic saponin adjuvant QS-21 for vaccines against cancer. Expert Rev Vaccines[Show abstract] [Hide abstract]
ABSTRACT: One of the most widely used and potent immunological adjuvants is a mixture of soluble triterpene glycosides purified from the soap bark tree (Quillaja saponaria). Despite challenges in production, quality control, stability and toxicity, the QS-21 fraction from this extract has exhibited exceptional adjuvant properties for a range of antigens. It possesses an ability to augment clinically significant antibody and T-cell responses to vaccine antigens against a variety of infectious diseases, degenerative disorders and cancers. The recent synthesis of active molecules of QS-21 has provided a robust method to produce this leading vaccine adjuvant in high purity as well as to produce novel synthetic QS-21 congeners designed to induce increased immune responsiveness and decreased toxicity.
Article: Human monoclonal antibodies to sialyl-LewisA (CA19.9) with potent CDC, ADCC, and antitumor activity. Clin Cancer Res[Show abstract] [Hide abstract]
ABSTRACT: The carbohydrate antigen sialyl-Lewis(a) (sLe(a)), also known as CA19.9, is widely expressed on epithelial tumors of the gastrointestinal tract and breast and on small-cell lung cancers. Since overexpression of sLe(a) appears to be a key event in invasion and metastasis of many tumors and results in susceptibility to antibody-mediated lysis, sLe(a) is an attractive molecular target for tumor therapy. We generated and characterized fully human monoclonal antibodies (mAb) from blood lymphocytes from individuals immunized with a sLe(a)-KLH vaccine. Several mAbs were selected based on ELISA and FACS including two mAbs with high affinity for sLe(a) (5B1 and 7E3, binding affinities 0.14 and 0.04 nmol/L, respectively) and further characterized. Both antibodies were specific for Neu5Acα2-3Galβ1-3(Fucα1-4)GlcNAcβ as determined by glycan array analysis. Complement-dependent cytotoxicity against DMS-79 cells was higher (EC(50) 0.1 μg/mL vs. 1.7 μg/mL) for r7E3 (IgM) than for r5B1 (IgG1). In addition, r5B1 antibodies showed high level of antibody-dependent cell-mediated cytotoxicity activity on DMS-79 cells with human NK cells or peripheral blood mononuclear cells. To evaluate in vivo efficacy, the antibodies were tested in a xenograft model with Colo205 tumor cells engrafted into SCID (severe combined immunodeficient mice) mice. Treatment during the first 21 days with four doses of r5B1 (100 μg per dose) doubled the median survival time to 207 days, and three of five animals survived with six doses. On the basis of the potential of sLe(a) as a target for immune attack and their affinity, specificity, and effector functions, 5B1and 7E3 may have clinical utility.
Article: Abstract 2417: Preclinical evaluation of potential novel synthetic saponin adjuvants with conjugate cancer vaccines
Article: The Known Immunologically Active Components of Astragalus Account for Only a Small Proportion of the Immunological Adjuvant Activity When Combined with Conjugate Vaccines[Show abstract] [Hide abstract]
ABSTRACT: The 95 % ethanol extract of Astragalus has been demonstrated to have potent activity as an immunological adjuvant when administered with vaccines of various types. We endeavor here to identify the components of this extract that are responsible for this adjuvant activity. Mice were immunized with KLH conjugated to cancer carbohydrate antigens globo H and GD3 and cancer peptide antigen MUC1 combined with different Astragalus fractions or with commercially available Astragalus saponins and flavonoids. The antibody responses against cancer antigens and KLH were quantitated in ELISA assays, and toxicity was calculated by weight loss. Astragalosides II and IV were the most active components, but the toxicity of these two differed dramatically. Astragaloside II was the most toxic Astragalus component with 5-10 % weight loss at a dose of 500 µg while astragaloside IV showed no weight loss at all at this dose, suggesting that astragaloside IV might be utilized as an immunological adjuvant in future studies. Several flavonoids also had significant adjuvant activity. However, when the activities of these known immunologically active components of Astragalus (and of endotoxin) are calculated based on the extent of their presence in the 95 % ethanol extract, they provide only a small proportion of the immunological activity. This raises the possibility that additional uniquely active components of Astragalus may contribute to adjuvant activity, or that the adjuvant activity of Astragalus is greater than the activity of the sum of its parts.
Article: Preclinical evaluation of the synthetic adjuvant SQS-21 and its constituent isomeric saponins. Vaccine[Show abstract] [Hide abstract]
ABSTRACT: The saponin fraction QS-21 from Quillaja saponaria has been demonstrated to be a potent immunological adjuvant when mixed with keyhole limpet hemocyanin conjugate vaccines, as well as with other classes of subunit antigen vaccines. QS-21 adjuvant is composed of two isomers that include the apiose and xylose forms in a ratio of 65:35, respectively. The chemical syntheses of these two isomers in pure form have recently been disclosed. Herein we describe detailed in vivo immunological evaluations of these synthetic QS-21 isomeric constituents, employing the GD3-KLH melanoma antigen. With this vaccine construct, high antibody titers against GD3 ganglioside and KLH were elicited when GD3-KLH was co-administered with adjuvant, either as the individual separate synthetic QS-21 isomers (SQS-21-Api or SQS-21-Xyl), or as its reconstituted 65:35 isomeric mixture (SQS-21). These antibody titer levels were comparable to that elicited by vaccinations employing naturally derived QS-21 (PQS-21). Moreover, toxicities of the synthetic saponin adjuvants were also found to be comparable to that of naturally derived PQS-21. These findings demonstrate unequivocally that the adjuvant activity of QS-21 resides in these two principal isomeric forms, and not in trace contaminants within the natural extracts. This lays the foundation for future exploration of structure-function correlations to enable the discovery of novel saponins with increased potency, enhanced stability, and attenuated toxicity.
Article: Abstract 2418: Low dose antibody against GM2 ganglioside results in accelerated tumor growth
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ABSTRACT: The success of antitumor and antiviral vaccines often requires the use of an adjuvant, a substance that significantly enhances the immune response to a coadministered antigen. Only a handful of adjuvants have both sufficient potency and acceptable toxicity for clinical investigation. One promising adjuvant is QS-21, a saponin natural product that is the immunopotentiator of choice in many cancer and infectious disease vaccine clinical trials. However, the therapeutic promise of QS-21 adjuvant is curtailed by several factors, including its scarcity, difficulty in purification to homogeneity, dose-limiting toxicity, and chemical instability. Here, we report the design, synthesis, and evaluation of chemically stable synthetic saponins. These novel, amide-modified, non-natural substances exhibit immunopotentiating effects in vivo that rival or exceed that of QS-21 in evaluations with the GD3-KLH melanoma conjugate vaccine. The highly convergent synthetic preparation of these novel saponins establishes new avenues for discovering improved molecular adjuvants for specifically tailored vaccine therapies.
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ABSTRACT: Autoantibodies to cancer antigens hold promise as biomarkers for early detection of cancer. Proteins that are aberrantly processed in cancer cells are likely to present autoantibody targets. The extracellular mucin MUC1 is overexpressed and aberrantly glycosylated in many cancers; thus, we evaluated whether autoantibodies generated to aberrant O-glycoforms of MUC1 might serve as sensitive diagnostic biomarkers for cancer. Using an antibody-based glycoprofiling ELISA assay, we documented that aberrant truncated glycoforms were not detected in sera of cancer patients. An O-glycopeptide microarray was developed that detected IgG antibodies to aberrant O-glycopeptide epitopes in patients vaccinated with a keyhole limpet hemocyanin-conjugated truncated MUC1 peptide. We detected cancer-associated IgG autoantibodies in sera from breast, ovarian, and prostate cancer patients against different aberrent O-glycopeptide epitopes derived from MUC1. These autoantibodies represent a previously unaddressed source of sensitive biomarkers for early detection of cancer. The methods we have developed for chemoenzymatic synthesis of O-glycopeptides on microarrays may allow for broader mining of the entire cancer O-glycopeptidome.
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Memorial Sloan-Kettering Cancer Center
New York, New York, United States
- • Department of Medicine
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Cornell UniversityИтак, New York, United States
Weill Cornell Medical College
New York, New York, United States
- Department of Medicine


text: We, a group or 15 friends stayed here for two nights. we liked it and I would have rated this hotel high, had not the following happened. When we went to breakfast the second morning, right before traveling on to the coast, some of us did a stupid thing, something I usually never do, we left our bag with money... More

subset: commoncrawl


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Home > News > World News
Posted on Feb 15, 02:23PM | IBNS
New York, Feb 15 : The United Nations Security Council (UNSC) Thursday extended for another year the mandate of the panel of experts monitoring United Nations sanctions imposed on Sudan in connection with the conflict in Darfur.
The panel was set up in March 2005 and is tasked with monitoring an arms embargo, travel ban and assets freeze, and informing the Council's sanctions committee about individuals who impede the peace process, violate international law or are responsible for offensive military flights in Darfur.
In a unanimously adopted resolution, the Council extended the panel's mandate until 17 February 2014 and requested it to "continue to coordinate its activities as appropriate with the operations of the United Nations/African Union Hybrid Operation in Darfur (UNAMID) and with international efforts to promote the political process in Darfur."
The 15-member body also voiced its concern that the direct or indirect supply, sale or transfer to Sudan of technical assistance and support - including training, financial or other assistance and the provision of spare parts, weapons systems and related materiel - could be used by the Government to support military aircraft being used in violation of Council resolutions.
Further, the Council "regrets that some individuals affiliated with the Government of Sudan and armed groups in Darfur, continue to commit violence against civilians, impede the peace process, and disregard the demands of the Council, and expresses its intention to impose targeted sanctions against individuals and entities that meet the listing criteria."
Darfur has since 2003 been wracked by conflict that pits Government forces and allied militiamen against rebel groups. Millions of civilians have been either internally displaced or forced to seek refuge in neighbouring countries.


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|Format: DRM Protected ePub
Vendor: Guideposts
Publication Date: 2011
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Series: Tales from Grace Chapel Inn
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Never a dull moment. Every page a good read. I loved it! Good for adults and teens.
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Selena Gomez by happytrentyWatch
©2014-2016 happytrenty
Size Approx 13"x 9 1/2"
Bristol board
great work!!!..this is so beautiful, her hair is lovel y as well....you are very talented!
Incredible! The detail is amazing and you have captured a great likeness
Great portrait, very good work in ornament details.
Amazing details and great depth in those black tones.
Not a big Selena Gomez fan, but I absolutely love this drawing.
it's awesome !! your work is wonderful ! how can you make all these details ?!
Damn good pencil work bro.
Great piece of work!!
Thanks for sharing....
Featured in Daily Inspirations at hangaroundtheweb.com/2014/02/d…
Thanks for sharing....
Featured in Daily Inspirations at hangaroundtheweb.com/2014/02/d…
Fabulous drawing!
Nice work
Beautiful work. It's very striking
NurVader: Impressive. Most Impressive!
Very well done! So much details
Very realistic; looks like the picture of an Empress! How long have you spent on this?
I stop counting after 20hrs ...Thank you so much
Excellent work, great detail and structures...a true masterpiece!
This must be the most difficult and detailed piece of yours. Excellent work.
Amazing work! You have wonderful pencil technique.
gorgeous art work!
Excellent !!!


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Verdun is the first multiplayer FPS set in a realistic First World War setting. The merciless trench warfare offers a unique battlefield experience, immersing you and your squad into intense battles of attack and defense.
The game takes place on the western front between 1914 and 1918, in one of the bloodiest conflicts in world history. The developers were inspired by the infamous Battle of Verdun France in 1916. The game includes many historically accurate features such as realistic WW1 weaponry, authentic uniforms and maps based on the real battlefields of France and Belgium.
The Frontlines game mode is unique in its tactical complexity. The realistic trenches are challenging to fight in and require tactical cunning to capture and defend. The Entente and Central Powers strive to gain control of frontline sectors. One battle you're rushing the enemy trenches during an offensive battle in order to gain ground. In another battle you might be defending your recently conquered ground against an enemy counter-attack.
Players can choose to be part of one of the many squad-types in the game, each of whom have their own distinct tactical role. By working together with your friends, you can earn experience that improves the power and versatility of your squad. As you gain more experience fighting and get promoted in rank, you also earn Career Points which you can use to unlock specializations, weapons and equipment.The Rifle Deathmatch is a free-for-all game mode, where all players are pitted against each other in a thrilling contest of skill using only bolt-action rifles.
Verdun key features include:
For more information, please visit Verdun on Steam, like us on Facebook, subscribe on YouTube, stream on Twitch TV and follow us on Twitter.
Test build live!
The test build for the upcoming content update is now available for selected testers! In the coming weeks we will trial the massive content and all its aspects (including gore, new artillery abilities, flamethrowers, 73 weapons and more) with the community. If you are reading this and think, "I would like to join as well!", look no further. You can sign up for the testing group here.
Upon joining the test group, you will be able to give feedback and receive a key for the Verdun testing application. You will be able to keep having the regular verdun client installed side-by-side. So what is in this update? The past months we have teased quite a lot, but there is still so much more to show:
This week we'll also be revealing a little more info about the upcoming map titled "Champagne". This map is based on the champagne front. A somewhat forgotten front, it saw major fighting in both 1915 and in the final offensive of 1918 which saw a major U.S breakthrough. The frontline is situated between Reims and the Argonne and consists mainly of open farmlands and hills. Many of these hills such as the "Main de Massiges" ("The hand of massages") were heavily fortified. Combined with the fact that the front was largely static between 1916 and 1917, Champagne serves as inspiration for a totally different style of map which is entirely centered around the fighting within the complex lines of trenches. This should really contrast with the other maps where large portions of the fighting takes place in or around nomansland. Another iconic element which has been added to the game through Champagne is also that of night fighting.Our level designer has created some of our most stunningly realistic trenches in this new map, that really should do justice to the extensive and chaotic trench networks that could be found on the western front. Take a look at these teaser images (which also incorporate some of the upcoming new squad types)
"German "Pionier" squad conducting a night raid on the champagne front using a flamethrower. Note the entrenching tools carried by the pioneers as well as their distinctive canvas-covered stahlhelm. Also in the image is a soldier wielding the artillery luger (with 32-round drum magazine) The 'Pionier' class officer is using a C96 pistol for this raid"
"French Night attack in the champagne sector, 1915. French troops wearing their mid-1915 transitional uniform attack the German stronghold at the "Main de Massiges" ridge. Note the french officer wielding a m1892 revolver."
"German sentries fighting off a night assault, possibly American, champagne front 1918. The iconic German "Sappenpanzer", which (while mostly impractical) saw fairly common use among German sentries."
We'd also like to introduce images of the new U.S squads in-game for the first time.
"U.S Doughboys and elements of Marines on a combined operation in the Champagne region. Known as the battle of "Blanc Mont Ridge" in October of 1918. Most obvious is the presence of the iconic M1897 winchester "Trench Gun". A feared and most deadly weapon in the close proximity of the trenches in Champagne."
"Outflanking a group of German sentries, Champagne 1918. The new map allows for tense close quarters combat, and thanks to a less-linear design of trench lines it becomes possible to surprise defenders and attackers by attacking from unexpected corners."
New feature: bullet extraction
New in the upcoming update is also animated extraction of the empty cartridges.
New Gasmask: The Small Box Respirator Last week we introduced the new first person animations for the French gasmask, the M2. This week we can show you the newly added SBR (Small Box Respirator). It has a distinctive tube and comprises of two main components, the mask and the box filter - usually carried in a bag and placed on the chest.
Note the iconic tube and a different experience from the current M17 mask
Chauchat M1918 .30-06 "The worst"
The U.S didn't have much in the way of a lightweight machine gun come 1917, so when it entered the war, the U.S forces were issued with French Chauchat LMGs. The U.S later developed the m1918 due to a series of issues that were commonly faced by soldiers within the front lines. Primarily, the open sided magazine (which had been a major issue for French soldiers in the mud of the trenches) was replaced with a boxed magazine and a conversion to accept .30-06 rounds. The M1918 will be used by U.S marine squad by the close combat support role. The .30-06 round gives a slightly different performance from the french m1915 chauchat. The fact that it was frequently ditched by troops in the field because of jamming will be reflected in the fire rate of the weapon.
M1917 Wechselapparat "Wex" Flamethrower T
he German Wechselapparat Flamethrower or 'wex' was developed in 1917 after successful but outdated Kleif flamethrower. Flamethrowers had seen use since the early years of the war, one of the first recorded uses being during 1915 near Verdun. As the war progressed flamethrowers grew in complexity as well as size - including the famous british Livens flamethrower. Come 1917 the Germans were in need of a lighter weight, more adaptable flame thrower - capable of being handles by one or two crew members. The 'wex' saw effective use in 1917/18 and was the basis for a number of flamethrowers including the Model 40 German flamethrower and portable No 2 British flamethrower in WW2.
The Wex will be used by German pioneer troops to counter the U.S marine squads. With limited range and fuel capacity, the wex will be a tricky weapon to master… however given the correct handler, it could quite possibly be the deadliest weapon to see action on the fronts of Verdun.
The C96 also received a great reloading animation of its stripper clip. This is just one of the many items you will be able to try in the test version.
The C96 cannot be reloaded mid-clip Some animation improvements have been done, last week we already saw the bullet extraction (though heavily a WIP).
This week we show some of the many new reload animations.
Gew. 98 reload animation, now forcefully pressing the bullets into the magazine
Reloading the Belgian FN1900, correctly pulling the slide upon insertion. Also note the Belgian officer sleeve
Now we'd like to tease some of the new features that have kept us busy. For a starters we have redone ALL the animations for all the first person weapons. Also weapon sights have been edited and they look a lot more immersive, for instance in this image:
The Belgian Kar 89 with updated sight picture
We also updated FP gas masks and added the allied French and British/American masks as first person models (No more German gas masks for all nations!) Here is a little teaser of the M2 mask:
Updated lens textures for more immersion
As a bonus little for the 24 hour update delay we'd like to demonstrate an awesome new feature that we are currently working on as part of the gore system: Updated Ragdoll physics/animation hybrids. Gore will be part of the upcoming content update testing phase. Some elements have been polished since our initial trials in October and it is now ready to test again.
Seamless blending between animation and ragdoll
Next time we shall reveal more features and some animated gifs of the verdun gore system (dismemberment being one of them) In addition to the new weapons and animations, Unity 5.3 allows for a new kind of Physically Based Rendering technique which allows for a nicer representation of metals in-game. Our artists have worked tirelessly since new years to update weapon materials (as was as working on all of the other things). Here an example of some of the new material work.
The ruby was also reworked
Screenshots of the Week
That will be all for this update. We hope to see a lot of applications for the closed test build and see you on the front!
From December 22 – January 4 2016 the game Verdun will reproduce the WW1 Christmas Truce. This is done by releasing a new dedicated winter map where...
Welcome back to another weekly weapon wednesday update! This week is rather special because we are happy to announce the return of a yearly verdun classic...
Welcome back to another installment of Verdun's "Weapon Wednesday". Today we have some new weapon images to present, want to ask you to help vote...
Welcome back to another installment of Verdun's "Weapon Wednesday", we use these media updates to tease upcoming content and provide you with an...
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About time they update.
can't we just get a release date?
check the official forums for progress
Is this game dead? It better not be, looks freaking awesome!
Is the game done? What's the latest progress?
looks awesome, tracking
We're still good under way we already did some nice multi player matches (with mp18 and g98 as a test). Plus we have a trench map made, we just need some polishing on art. We will most likely go professional in the fall season. We got a British, two German, a French and a US character running in game using procedural animation. The basic framework of the game is there.
if there making this into a game its going to take awhile so give them a chance and if not its probaly dead
What Connection does this have with BF1918? and is it dead? I remember that you guys had a alpha estimate for last summer or something like that : /
Highest Rated (2 agree) 9/10
Verdun is one of those games that comes along only once in a lifetime, and I've had an immeasurable amount of fun with it. It takes the harsh scenario of trench warfare and almost flawlessly merges it into squad based large battles. The game isn't very far off from how it would work in real life either. One side launches an offensive to take the trench, and if successful, would hold that line for the inevitable counterattack. That system plus close to realistic combat makes for a very fun multiplayer…
May 10 2015 by makepizza


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Kiehl's Ultimate Strength Hand Salve
126 reviews
80% would repurchase
Package Quality: 4.1
Price: $$$
Package Quality: 4.1
Price: $$$
INGREDIENTSAqua/Water, Glycerin, Caprylic/Capric/Stearic Tiglyceride, Butylene Glycol,Aluminum Starch Octenylsuccinate, Hydrogenated Stearyl Olive Esters, Butyrospermum Parkii/Shea Butter, Ceteary Alcohol, PEG-75 Stearate, Glyceryl Stearate, Cetyl Alcohol, BIS-Diglyceryl Polyacyladipate-2, Sesamum Indicum/Sesame Seed Oil, Squalane, Dimethicone, Ceteth-20, Phenoxyethanol, Persea Gratissima/Avacado Oil, Steareth-20, Ceteareth-20, Methylparaben, Sodium Dehydroacetate, Tocopheryl Acetate, PPG-5-Ceteth-20, Eucalyptus Globulus/Eucalyptus Globulus Leaf Oil, Allantoin, Disodium EDTA, Aloe Barbadensis/Aloe Barbadensis Leaf Juice 685230/5 Code F.LL.: D8409/1 Made In U.S.A. 1/26/12
Age: 36-43
Skin: Combination, Fair-Medium, Not Sure
Hair: Black, Other, Other
Eyes: Brown
I admit that I am a bit of a hypochondriac and germ freak. As such, I find myself constantly washing my hands, which in turn causes skin dryness from the frequent soap and water use. I used to use hand lotions from Victoria's Secret or Bath & Body Works, but found that I was buying the lotions for the delicious scents, not because they worked well at moisturizing my hands. After that revelation, I started to use the Bath Shop's Almond Oil Daily Hand & Nail Cream, which worked well, but it took a while to heal my sometimes really rough, dry, and cracked hands. And then I found Kiehl's Ultimate Strength Hand Salve and...HALLELUJAH!
The lotion is a thick salve that offers "heavy-duty moisture treatment" for "all-day care and protection." All I need is just a little bit to moisturize both hands as too much will leave a grubby and slightly sticky feeling. The salve contains avocado, sesame, and other botanical oils and natural wax from olive oil to sooth, moisturize, and condition your hands with a slight fragrance.
Due to the thickness of the salve, I usually use it right before I go to bed so that I can allow the salve to work its magic. My hands are instantly soft and smooth and it soothes my cracked skin and allows for them to heal quickly. Dry patches on my hands are remedied faster than when I use the Body Shop hand cream and because I use a small amount, a 2.5 ounce tube lasts me months. I use my Body Shop hand cream during the day due to its light non-greasy formula (and also helps with my nails) and my Kiehl's salve at night. I find that this combination protects my hands through all the hand washing I perform on a daily basis. Despite it being a bit pricey ($13 for a 2.5 oz. tube and $20 for a 5 oz. tube), I highly recommend the hand salve because it is the most effective hand cream I've ever used!
Age: 19-24
Skin: Combination, Tan, Not Sure
Hair: Brown, Other, Other
Eyes: Brown
One of my favorite hand creams, my hands tend to get really dry and this helps ALOT I LOVE IT!!!
Age: 30-35
Skin: Combination, Fair, Cool
Hair: Blond, Kinky, Fine
Eyes: Green
I LOVE this stuff, it's amazing!
Age: 36-43
Skin: Normal, Other, Not Sure
Hair: Brown, Other, Other
Eyes: Brown
I use this all winter long! I put the cream on, and then put on those long rubber gloves from the Asian groceries, and wash my dishes in hot hot water. When the dishes are done, moisture is back in my skin again. Even though it hurts sometimes when my hands are cracked from dry skin, it's a sign of it working, so I love this stuff, it works so well!
Age: 18 & Under
Skin: Acne-prone, Tan, Warm
Hair: Blond, Wavy, Medium
Eyes: Green
Finally I found a cream for my dry, chapped hands! My hands have been through hell and back I suppose. Antibacterial sprays, dishwashing liquid, soaps, handwashes, the Russian winter doesn't help either. I have tried tons of creams, and they seemed to have an initial effect but at the end of the day my hands were as dry as before.
This cream is great! It protects my hands, and my hands have become more hydrated in the long term. I am a pianist so I cannot afford to have greasy fingertips, and this cream absorbs really fast and has a non-greasy, silky finish. The sent is a very fresh, pleasant eucalyptus, which is also awesome and a departure from the traditional flowery scents for hand creams.
Age: 19-24
Skin: Combination, Fair-Medium, Not Sure
Hair: Brunette, Wavy, Coarse
Eyes: Brown
I live in Canada, so the harsh Canadian winter does a number on my hands. I use this cream and it softens them right up. it is a tad expensive, but I find that you don't need too much or else your hands will be too slippery. Overall, fantastic for hands, dry or not!
Age: 25-29
Skin: Combination, Fair, Not Sure
Hair: Black, Other, Other
Eyes: Brown
It's pricey but worth it. My hands used to get really bad to a point where it used to slightly bleed and scab over but after using this creme for a day helped my hand dramatically just in a day. It does have that medical scent to it but it doesn't last very long. I also used it on my feet as it started to crack and it helps that as well. The packaging is really tough as well.
Although it is expensive, you only need to apply small amount and it lasts through at least 2 washes. I found that I could wash my hands up to 5 times and not have to reapply.
Must have product for winter. This handcream is a huge blessing for hand that really gets a beating.
Age: 30-35
Skin: Combination, Medium, Warm
Hair: Black, Wavy, Coarse
Eyes: Brown
This is a nice hand cream, but I wasn't too impressed by it. However, my skin is not too dry, I don't garden, and don't work in health services etc. I have a cushy desk job, so my hands aren't being damaged by being overworked.
I find this cream too thick and makes my hands feel sticky. The eucalyptus "cooling" effect is nice, but very temporary, and seldom do I need to soothe my hands this way.
In general, I find that all the Kiehl's products I've tried are way too overpriced for chemical-based cosmetics, and don't deliver the astounding results I would associate with the price tag.
Age: 36-43
Skin: Combination, Fair, Not Sure
Hair: Brown, Other, Other
Eyes: Hazel
I really like this handcream and dare I say it is HG for me.
I struggle with my hands. I work in a hospital and need to wash my hands frequently, and use the alco-gel frequently, all of which is extremely drying. In the winter all of this plus the weather leads to cracks around the cuticles, hang nails and general uncomfortableness.
In the summer the discomfort is marginally less.
I am a handcream tart and have tried many with limited success, as I find that they just don't seem to be effective and need constant reapplying which frankly I forget to do, or they leave an awful greasy residue, or no residue at all so that my hands feel as if all the moisture has been sucked out, or the smell is pungent and lingering.
This hand cream is utilitarian - a tube with a flip lid. It is a good thickness but with spreadiblility, a slightly medicinal smell, it sinks in enough to prevent the greasiness, but not enough to make the need to reapply a priority. This really is the only hand cream I have tried that has worked.
As another reviewer said it seems to put an invisible glove over the hands and fingers. In UK it is �18.50 for 150mls.
Age: 30-35
Skin: Sensitive, Fair, Not Sure
Hair: Red, Other, Other
Eyes: Blue
This is the best hand cream that I have ever used. My hands used to crack so painfully during the winter but I haven't had that problem since I started using this cream. I love that it is fragrance free so it's safe for sensitive skin, but it still smells nice.
My only complaint is that it is hard to get the cream out of the tube when the contents gets low.
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text:
Company Overview of Public Joint Stock Company Delta Bank
Company Overview
Public Joint Stock Company Delta Bank provides a range of banking products and services to individuals, corporate clients, and small and medium-sized businesses in Ukraine. The company accepts deposits, as well as offers consumer lending services. It operates approximately 250 branches. Public Joint Stock Company Delta Bank was founded in 2006 and is based in Kiev, Ukraine.
36 B, Schorsa Street
Kiev, 01133
Founded in 2006
380 44 391 5135
380 44 391 5111
Key Executives for Public Joint Stock Company Delta Bank
Public Joint Stock Company Delta Bank Key Developments
Deposit Guarantee Fund is planning to sell nine insolvent banks' assets for UAH 225 million this week (August 24-28), reads a statement made by the Fund. In particular, it will offer for sale permanent assets of Open Joint Stock Company REAL BANK for UAH 82.6 million, Public Joint Stock Company AvtoKrazBank for UAH 24.2 million, Public Joint Stock Company AktaBank for UAH 182,120, Public joint-stock company Bank Kyiska Rus for UAH 2.13 million and Public Joint Stock Company Delta Bank for UAH 16.86 million.
The Private Deposit Guarantee Fund has received two application from private investors for the acquisition of assets and liabilities of Public Joint Stock Company Delta Bank. The last day to submit such bids was April 3, 2015. "A meeting on this subject will take place there on Tuesday. This document will also be submitted to our parliamentary committee. We will also study it and draw up our proposals. Its essence is to extend for Delta Bank the deadline for adopting decisions. Proceeding from the current legislative framework and the decisions already taken, the time to at least do something to save it is not much - until May 3," said Serhii Rybalka, Chairman of the parliamentary committee on fiscal policy and banking.
The Individuals' Deposit Guarantee Fund has extended its search for potential investors to withdraw Public Joint Stock Company Delta Bank from the market until April 3, 2015, the Fund has reported on its website. Only banks are allowed to buy and transfer bank liabilities, the report said. The Fund has proposed the following conditions for potential investors: the sale of all or part of assets and liabilities of a bank on sale to a buyer bank, the creation of a transition bank and sale of it to the investors with simultaneous transfer of the assets and liabilities of a bank on sale or the sale of an entire bank on sale.
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Sponsored Financial Commentaries
Sponsored Links
Only a company representative may request an update for the company profile. Documentation will be required.
To contact Public Joint Stock Company Delta Bank, please visit www.deltabank.com.ua. Company data is provided by Capital IQ. Please use this form to report any data issues.
Our data partners will research the update request and update the information on this page if necessary. Research and follow-up could take several weeks. If you have questions, you can contact them at email@example.com.


text:
iHerb Customer Reviews
Not so good
Posted by Reviewer2188425 on Jan 23, 2012
I have oily hair, and it works well for cleaning that away. Perhaps too well, because I developed dandruff after using this shampoo. Not for me.
not cleanable
Posted by Reviewer1198613 on Sep 21, 2012
my hair feel oily
Volumizing Rosemary Shampoo
Posted by anetta on Sep 21, 2012
Unfortunately this one is not for me, this shampoo makes that my hair is rather thinner than thicker and so it seems that there are fewer, so I came back to Biotin Therapy Shampoo from the same company which is great! I gave it two stars for the organic ingredients only.
not for me
Posted by titmog on Oct 31, 2012
leaves hair shiny day 1 but dried on the long term
Posted by namtoc on Jan 27, 2013
This shampoo dries out my hair too much, and doesn't help to get more volume..


text:
|Quick links:
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February 7, 2014
UK takes us-vs.-them approach to Mississippi State
It's taken him months, coach John Calipari said, but he's finally done it.
He's convinced his team that "everybody" is against them.
"They now believe it," Calipari said. "And it's made them play better."
Calipari's comments came at the end of a long answer about whether he truly believes, as he said last week, that Kentucky is the most overanalyzed team in any sport, anywhere.
Regardless of the answer, the result, if true -- that it's made Kentucky play better -- is really what matters to Calipari.
Especially when the Wildcats are about to embark on another two-game road trip, where it's obvious everybody in the arena is against them.
That starts Saturday with a game at Mississippi State (13-9, 3-6 SEC).
"Honestly, we kind of like to play on the road," senior guard Jarrod Polson said. "Us against the world."
It will be the teams' second matchup this year (and the first time since 1991 these two teams have met twice in the regular season), following a 85-64 win in Kentucky's opening league game.
But in that eventual win, Mississippi State held a three-point halftime lead.
"They left our building saying, 'we can beat these guys,'" Calipari said.
That's why, despite the Bulldogs' losing conference record, Kentucky's players are ensuring they don't overlook them.
"We definitely don't want to do that," freshman guard Dominique Hawkins said. "We know playing in the SEC, anything can happen."
"I think (we've) already learned that any road game in the SEC is tough," Polson said.
One player who can provide the steadiest hand is freshman guard Andrew Harrison, who has drawn consistent praise from Calipari recently.
That's a change from the consistent ups-and-downs he experienced earlier in the season, which included that first game against Mississippi State in which he scored eight points on 2-of-7 shooting with two assists and four turnovers.
"What I've seen him develop is just taking the ball, being a leader and controlling the game," Hawkins said. "Earlier in the season, he wasn't talking as much. But now he's talking to the whole team. He's basically the leader of our team, I feel like."
Kentucky needs a leader, both for the season as it pushes forward through outside criticism and more road tests, beginning with the Bulldogs and their white-out game.
"They're not going to walk away from us," Calipari said. "This is a great challenge."


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Keep your house clean and fresh with this bundle of eco-friendly cleaning supplies:
Stain Solution: We know how frustrating tough stains can be -- whether red wine or coffee. Whether you're rescuing a brand-new shirt or reviving your antique bedding and heirlooms, just one drop of this powerful solution safely removes stubborn stains, old and new. Best of all, it's safe for all washable fabrics--both whites and colors.
All-Purpose Bleach Alternative: This excellent alternative to bleach removes tough stains, brightens, and whitens. It's completely color-safe, non-toxic, biodegradable, and allergen-free.
Wash & Stain Bar: This bar works for both general washing up, and tough stains. It's got a classic clean laundry scent that combines lily of the valley and jasmine with sweet musk, sandalwood, and a touch of citrus. * Made of: Vegetable soap, borax, and essential oils * Size: 2 ounces
Sourced from: The Laundress
Standard Shipping: Ships out within 3 business days.
Note: Additional charges apply for shipments to Alaska and Hawaii.
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- Secure Shipping Containers in Bluffdale, UT.
- All Steel Container Products.
- Rent or Purchase.
Shipping Containers in Bluffdale
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Try to see what an extra wide shipping container in Bluffdale, UT costs, need to fit my car inside.
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20 Ft Container Rental
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I just need a container for a few months until we finish the building project.
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Sandy, UT, 84091
40 Ft Container Rental
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Job site needs a container almost a year until we finish construction.
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Sandy, UT, 84090
20 Ft Container Rental
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About This Activity
The Colors of Hope 5K Walk Run is a one-of-a-kind experience!This family friendly event is about enjoying a color crazy day while showing your support for Mt. Hope Sanctuary. Wearing a supplied white t-shirt, you will pass 6 different stations along the designated course. Volunteers will throw a different colored, non-toxic, powdered paint at your t-shirt ... providing a colorful souvenir of the event. Be prepared ~ you will get MESSY! All proceeds from this event benefit Mt. Hope.
For complete details and information please visit our website and click on The Colors of Hope Walk Run www.mthopesanctuary.org


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Wine, tasty food, olive oil and intriguing vendors are only a small part of the 33rd annual Lodi Spring Wine Show, Friday, March 22 to Sunday, March 23.
In addition to wine tasting from more than 40 wineries, local food purveyors offer sumptuous food including garlic fries, chicken chilaquelas, cheese of all kinds, kettle corn, Lakewood Meats sausage, chocolate, breads an spreads and more.
Local olive oil producers will offer samples and sell their tasty olive oils and balsamic vinegars.
Patrons will have the opportunity to kick back in the LoCA Lounge, presented by the Lodi Winegrape Commission, or sit and enjoy cooking demonstrations.
Visitors can shop at one of the many vendor booths selling everything from wine barrel furniture to jewelry, designer gourd lights to wine tags, or get your wine glass custom etched on site to commemorate the occasion.
Stogies Cigar Lounge will be on hand selling premium cigars on the cigar and port patio; Wine 101 will feature wine tasting seminars and area winery information, and the Lodi Amateur Vintners Association can explain all about home winemaking.
Don't miss the chance to win more than 100 bottles of wine in the Ultimate Wine Basket raffle. For only $20 you can purchase a ticket and possibly walk away with an instant wine collection. All proceeds benefit the Bucks-for-Books scholarship fund.
The 2013 Lodi Spring Wine Show is in the Ole Mettler Grape Pavilion at the Lodi Grape Festival grounds, 413 E. Lockeford St. in Lodi. The show is from 6 to 9 p.m. on Friday and from 5 to 8 p.m. on Saturday.
Tickets are $30 in advance and $35 at the door, and can be purchased at grapefestival.com, Raley's Camera Department in Lodi, Van Ruiten Family Winery, Lodi Wine Cellars, cellardoor, Lodi Avenue Liquors or the Lodi Grape Festival Office.
The event is sponsored in part by F & M Bank and the Lodi Winegrape Commission.
For more information visit grapefestival.com or call 209-369-2771.


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Queens Library
Sponsored By
Report: NYC Public Libraries In Poor Physical ShapeAbout $1.1 billion is needed to fix things like broken air-conditioning and other problems at the three city library systems, the report said.
Broad Channel Library Reopens After Being Wrecked By SandyA Queens community still reeling from superstorm Sandy now has one of its most treasured gathering places back.
Queens Library Becomes First In NY Public Library System To Lend E-ReadersUnder the pilot program, 50 e-readers preloaded with e-books will be available for check out at the library's Central Library in Jamaica, starting on Thursday.


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69 posts tagged with kids and education.
Displaying 1 through 50 of 69. Subscribe:
Your favorite Japanese media and language resources!
I am looking for specific Japanese language resources that fall into two groups: adult intermediate-to-advanced level, and early childhood education for Japanese kids. Please share your recommendations! [more inside]
Tell me about your / your kids' experiences in weekend language school
We are thinking of enrolling our (half-Japanese) 5yo son in ほしゅうこう, Saturday Japanese school. I understand the pros - he's unlikely to attain any kind of conversational proficiency unless he has a formal impetus. But I'm worried about the cons: stress, anxiety, lots of extra homework, major reduction in family time. I'd love to hear from people who attended weekend language school as a child, or who have enrolled their child in one. Or even religious school, if it had a significant time commitment. Of course every family and every child is different, but I'm interested in hearing a variety of experiences of how it did or didn't work for you. [more inside]
Microscope fun for toddlers - household substances edition
Dear hivemind: I'm going to bring a 300X video microscope to my daughter's preschool. What easily obtainable substances will be super cool to view? Bacteria are too small, red blood cells are a biohazard. Toddlers could care less about onion skins, cork, and plant vasculature in my experience, and I am not doing anything that requires fixing/staining. [more inside]
How to encourage effort, self-discipline, excellence in children?
My daughter is 5 and starting kindergarten and music lessons. I cannot lie: in these and her future...I dunno, endeavors I guess you would call them, I want her to do well. I want her to put effort in and take pleasure in her efforts. But I don't know how to foster this in her and it's time I started figuring it out. [more inside]
I don't know what or how to teach my 5-year-old about god...
My daughter is starting kindergarten at Catholic school. We are atheists (although raised Catholic). She will be learning about god in school, learning prayers, etc. and I basically just realized that I have NO CLUE how to navigate this. Do I let her believe, or do I tell her it's all just pretend? Is there an in between? Please help. [more inside]
How Do I Introduce My 8-Year-Old Minecraft Nut To Computer Programming?
My 8-year-old son is obsessed with Minecraft, and has announced that he would like to create video games when he grows up. My own IT skills topped out around 1982 when I learned to write programs in Basic that printed my name in an endless goto loop. What technologies/languages/apps can I introduce him to in order to leverage his enthusiasm and channel it to something that teaches him age-appropriate programming skills? Assume second-grade math and logic skills and no programming background whatsoever.
Spanish kids' shows for 6-year-old, first-year student?
Our daughter just finished her first year of Spanish in a full-immersion kindergarten. We're looking for good all-Spanish TV shows we can show her (and my wife, who wants to learn) over the summer so she doesn't forget it all. [more inside]
Short kid appropriate movie or tv scenes about ignored deafness?
I watched The Aviator last week and like how they portrayed Howard with his deafness; inappropriate answers from guessing wrong, how people stepped in to cover for him, etc. are there other examples I can "super cut" or just string together by searching and presenting instructionally? [more inside]
Multiplication and division resources for a 1st grader
My first grader is asking about multiplication and division. Where do I start? [more inside]
Learning alphabet and numbers for a 3 year old
I'd like to find some games (or other techniques) to play with my 3 year old in order to learn alphabet and numbers. From experience, learning through fun is much better for everyone involved, but may not necessarily be the case here. Please point me in the right direction so I can try some things to see what actually works.
Books that a 2nd-grade boy would enjoy reading.
My wonderful partner has a 7-year-old, 2nd-grade son who is having a little trouble keeping up with his peers in the reading department. We're trying to give him some extra attention in that area so that he can catch up, and we'd like to try and foster in him a genuine interest in reading. What books (or comics, or anything) could we give him that he might like, and which would be appropriate for his reading level? [more inside]
community orgs for arts and technology?
Which organisations, companies, community groups, etc support and encourage embracing both arts/humanities AND STEM (especially technology)? [more inside]
Seeing inspirational and mind-blowing videos for kids
What can I show children to inspire and wow them? I teach children aged between 9 and 11. I'm looking for video clips (or other) to show the children that will blow their minds - or at least, prompt discussion, broaden their horizons and take them outside of the confines of the four walls of the classroom. [more inside]
Child's teacher appears to be off the rails--suggestions for a parent?
I've got a third grader in public school who's having a rough year with her teacher. The teacher is out half the time, with a rotating cast of substitutes. When she's there she's explosive and calls the kids names and told them that she starved a beloved class pet to death over the holidays. What should I be doing? [more inside]
What are the best ways to teach mathematics to elementary age children?
What do you do to teach your children math (or maths)? [more inside]
Schooling on the East Coast
Hi all, I am looking for resources for figuring out the best pre-schools and schools on the East Coast (public and private both are fair game). Is there a national database ranking the schools? I am particularly interested in the Boston/Cambridge area, but am curious for my own personal reasons about schools in NYC as well as Chicago, and maybe the East Coast in general. My kid is 7 months old and definitely not ready to go to school just yet. But as I am originally not from this country, I'd like to familiarize myself with the system fully before I have to enroll her in school. In my humble opinion, schooling is very important - if it wasn't for a good school, I won't have the necessary life skills myself (irrespective of the professional and grad training), so I am hoping to be aware of the US school landscape before my little one starts going to preschool. Many thanks for your kind help. Have a nice day!
Surreptitious assessment of smart 11-year-old?
I occasionally hang out with a smart 11-year-old girl, am a friend of the family. She's ahead of her peers in reading and math, starts 6th grade in the fall, but is not especially challenged by her public school. A few years ago in a different school district, they offered to skip her a grade (this option was not chosen). [more inside]
Separating Twins into Different Classes at School?
My (boy / girl) twins will be entering kindergarten this September. We've been asked if we want them placed into separate classes, or left together in the same class. Need to give them our answer by Monday and frankly, I'm at a loss and have no idea what I should do. If you are a parent of school-age or older twins, can you please share what you did and why? If you yourself are a twin, how did your parents handle it? How did it work out? Other knowledgeable anecdotes and advice welcome. Links to any online resources I can read on the topic would also be appreciated.
What is the best non-fiction book for kids in your field of study/work?
My kids (currently 6 and 9) have become voracious readers. We have a large and varied collection of excellent fiction for them, but the non-fiction collection is more haphazard. They love learning new facts as they read (the type of thing that makes them look up from the book and say, "Did you know...?"). I want to make sure that the collection of books gives them a good introduction to fields where I myself may not have enough knowledge to judge the quality/accuracy of the book. So what's the kid's book in your field that makes you say, "If only every kid got to read this book, people would understand [topic] better."? [more inside]
How can I thank parents for doing a fantastic job?
How can I (should I?) thank parents for doing a fantastic job? [more inside]
Possible to compbine babysitting and music lesson? how to find teacher?
I am a mother of 3 kids, age 2,4,10. I need babysitter to take care of my kids for 1-2 hours during the weekend, so that I can run other errands. But it seems that babysitters typically look for more work (money) than 1-2hrs ($30)/job (with typical rate of $15/hr). I am willing to pay $30 to $60 per hour if the babysitter can teach the kids music, dance, gym, drawing or other arts and can involve all three of my kids. [more inside]
How can I be a great children's librarian?
I recently changed jobs from a teen librarian to a children's librarian. I have solid public service skills, but I feel like I'm behind the curve in terms of preparedness. Help me be the best children's librarian ever! [more inside]
Looking for fun day plans for home-schooled kids.
Looking for fun day plans for home-schooled kids. [more inside]
Make my daughter POTUS someday
What does a 9-year-old need to do now to become President of the United States? [more inside]
Would You Move for Better Schools?
Moving to a better school zone. Should I do it? Tough decisions concerning moving, staying put, and financial future. [more inside]
Looking for cool stuff online for my four year olds.
I'm looking for websites that have cool, educational, entertaining and kid-safe stuff I can share with my two 4 year olds, perhaps similar to the kids should see this, and/or sites that suggest neat projects and how-to's my wife and I can work on with them to open their eyes to the wonders of the world around them. All suggestions welcome!
Let's not get back problems this young
What non-computer based activities can I use to teach video game development to 10-12 year olds? [more inside]
Teacher-Filter: Looping?
Teacher-Filter: Looping? [more inside]
Computer excitement for a smart kid?
Looking for computer/internet recommendations for my 10 year old friend. What are the coolest, most interesting, and least consumerist activities, websites, and other digital/virtual things that I can introduce this kid to? What did you like to do with computers / the internet when you were that age? Bonus internet safety questions inside! [more inside]
Spoken word for kids?
Favorite spoken words/performed poems for kids? [more inside]
Will not sending my kids to preschool doom them to poverty, prison, drug addictions, despair, etc?
Will not sending my kids to preschool doom them to poverty, prison, drug addictions, despair, etc? [more inside]
Which method of homeschooling is the most successful?
Which method of homeschooling is the most successful? [more inside]
Avoiding the "summer slide"
Primary school gets out tomorrow. I know it is common for kids to have a "summer slide" where they forget a lot of what they've learned over the year. Recommend some fun math and science sites/projects/activities for elementary school age kids that will keep them refreshed and interested. [more inside]
Suggestions please for good food plants for kids to grow on our balcony.
Apart from tomatoes, strawberries and beans, what can we grow on our sunny central European balcony? [more inside]
Talking to young kids about reproduction
Looking for tips on teaching/discussing reproduction to kindergarten age children. [more inside]
Extra homework, Dad? Again?
What are some good resources for at-home K-4 education exercises? [more inside]
Half day schools in the United States
My son is nearing kindergarten age and we're exploring our options for his education. We stumbled across this "Family School" in Albuquerque, NM, and we love the concept of half day public school and half day home school. Does anyone know of public (or private) elementary schools anywhere in the United States with a similar setup to this?
Which NYC preschools teach kids to read?
What New York City Preschools teach children reading before they get to kindergarten? I'm looking for names. Thank you!
"Guys, other teachers may glossed over this evolution thing, so today..."
What's the best way to financially support of evolution education in Kansas? [more inside]
Family astronomy time!
Family astronomy activities? [more inside]
Do my numerous constraints rule out meaningful work with kids?
I'd like to learn about jobs that involve working intensively, one-on-one, with preschool or elementary-aged kids, to help them learn or develop. But, I have so many constraints that I'm not sure any role fits. Could you point me to any possibilities? [more inside]
Educational Media
Can you recommend some great educational media for my nearly two year old daughter? I am looking for good DVD's, computer / iPhone software, or websites that I can load up for 30-60 minutes a day. I would like something she can learn from, but if she is having fun, that is cool as well. Right now she is a Dora and Diego addict. I just got her a few LeapFrog preschool DVD's that she loves. She can sing her ABC's and can count to 10 in English and Spanish. She is just starting to be able to answer "How does the letter A, B, C, etc. go?' She knows how to flip pages and push buttons on the iPhone. Are there any computer learning games that a two year old could handle. Flash games? iPhone games? Answers to this question do not involve telling me to take my daughter outside. I am familiar with the debunking of Baby Einstein. I would just like to find some good stuff for her to watch, play or interact with. General toy recommendations are good as well.
Robot toys and fiction on the topic of robots / artificial intelligence and learning?
Robot toys and fiction on the topic of robots / artificial intelligence and learning? [more inside]
BostonFilter: Where is the coolest place to take a 5-year-old in Boston, Massachusetts?
BostonFilter: Where is the coolest place to take a 5-year-old in Boston, Massachusetts? [more inside]
Where are all the up-and-coming, innovative charter schools?
I can work in any US city and am committed to doing so for two years. Where can I teach that will be stimulating and engaging, in a community I will love? [more inside]
Legit math sites for kids!
Legitimate math websites for k-5 students. [more inside]
Books for the junior engineer
Are there any good books out there for your 6-10 yr. old child who shows an interest in engineering? [more inside]
Help me keep the shutterbugs happy!
What should I include in a 3 hour photography workshop aimed at 30 12-15 year olds? [more inside]
Funky science displays for kids?
I have just started as a school science technician at an inner city school. Over the holiday I would like to spruce up the 5 science classrooms with displays covering the various disciplines. Does anyone know of any online resources, posters to download/print etc? [more inside]
Libraries are awesome
I've taken responsibility for a very small children's library and I'd love your ideas for making it awesome. [more inside]
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Polish Apple Pancakes Recipe
4.5 2
"MY MOM used to make these wonderful pancakes for me as an after-school snack. She'd simply put a sprinkle of confectioners' sugar on top. What a delicious treat!"
- 1 cup all-purpose flour
- 1 tablespoon sugar, optional
- 1/2 teaspoon salt
- 1 egg
- 1 cup fat-free milk
- 1 tablespoon canola oil
- 5 medium apples, peeled and thinly sliced
- Confectioners' sugar, optional
- In a bowl, combine flour, sugar if desired and salt. In another bowl, lightly beat egg; add milk and oil. Add to dry ingredients and stir until smooth. Fold in apples.
- Pour batter by 1/2 cupfuls onto a lightly greased hot griddle and spread to form a 5-in. circle. Turn when bubbles form. Cook the second side until golden brown and apples are tender. Sprinkle with confectioners' sugar if desired. Yield: 5 servings (16 pancakes).
Originally published as Polish Apple Pancakes in Reminisce May/June 1994, p51
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ATP World Tour Brasil Open Results
Updated: February 11, 2013, 6:35 PM ETAssociated Press
At Ginasio do Ibirapuera
Sao Paulo
Purse: $519,775 (WT250)
Surface: Clay-Outdoor
First Round
Pablo Andujar (7), Spain, def. Santiago Giraldo, Colombia, 6-4, 7-6 (5).
Martin Alund, Argentina, def. Ricardo Mello, Brazil, 6-4, 6-4.
Simone Bolelli, Italy, def. Tommy Robredo, Spain, 6-2, 6-4.
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Funding via Organizacion de Desarrollo Empresarial Femenino (ODEF)
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Olanchito ,Yoro, Honduras
Food Stall
Loan Overview
Repayment Schedule
Loan Updates
Aurelia is 35 years old, in a common-law relationship, and has three children. She lives in the town of Olanchito, Yoro.
Aurelia has been in the business of selling food for 12 years. She sells her food in the outlying areas where there are several other businesses. She offers "baleadas" (Honduran stuffed tortillas), corn dumplings filled with meat, and soft drinks. Aurelia says she is pleased because she is able to sell all of her food to people who know her. She already has her own customers. Aurelia has been able to get ahead through hard work and effort so that she can help her household companion with the family expenses.
Doña Aurelia has already obtained 10 loans from ODEF. These loans have been a great help by allowing her to invest in her business and other needs that arise. Now she is requesting her 11th loan in the amount of 10,000 HNL so that she can buy supplies that she needs for preparing her dishes such as flour, beans, eggs, dairy products, meat, cornmeal, rice, and soft drinks.
This is a short term loan that she is asking for with two payments over two months.
Her goal is to continue working in her business so that her family can move forward.
Translated from Spanish
View original language description ↓
Aurelia tiene 35 años de edad, vive en unión libre, tiene 3 hijos, y vive en el municipio de Olanchito, Yoro.
Aurelia hace 12 años se dedica al negocio de venta de comida, ella vende sus alimentos en la afueras donde hay varios negocios ofreciendo baleadas, pastelitos de maíz relleno de carne y refrescos. Dice que se siente contenta porque vende todos sus alimentos, las personas la conocen y tiene ya sus propios clientes. Ha logrado salir adelante con mucho trabajo y esfuerzo para ayudar a su compañero de hogar con los gastos de la familia.
Con odef Dona Aurelia ha obtenido ya 10 créditos los cuales le han ayudado mucho en la inversión de su negocio y para otras necesidades que se le han presentado, ahora esta solicitando su préstamo numero once de 10,000 lempiras para comprar insumos que necesita para elaborar los alimentos como harina, frijoles, huevos , lácteos , carnes, maseca, arroz y refrescos. Es un prestamo a corto plazo que solicita con pago bimestral, pagara una sola cuota dentro de dos meses.
Su meta es seguir trabajando en su negocio y sacar su familia adelante.
Additional Information
About Organización de Desarrollo Empresarial Femenino Financiera, S.A.
This loan is administered by Organización de Desarrollo Empresarial Femenino Financiera, S.A. (ODEF), a Kiva Field Partner in Honduras. A leader in the microfinance sector since 1985, ODEF strives to combat poverty by offering a wide array of financial services to low-income men and women. The organization works with its parent NGO, ODEF OPD, to provide training and technical assistance to impoverished microentrepreneurs. By incorporating the entire family unit in this process, ODEF OPD aims to improve the standard of living through the creation of profitable enterprises. Visit ODEF's
partner page
for more information.
About Honduras
Average annual income
View loans »
Honduras Loans Fundraising
Funds lent in using Kiva
Honduras Lempiras (HNL) = $1 USD
Success!! The loan was 100% repaid
A loan of $525 helped Aurelia to buy flour, beans, eggs, dairy products, meat, cornmeal, rice, and soft drinks.
Find a Loan
Repayment Term
4 months
(Additional Information)
Repayment Schedule
At end of term
May 14, 2012
Jun 18, 2012
Currency Exchange Loss:
Aug 16, 2012


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Every Day vs. Work Day
"On a day-to-day basis, you want that natural glow and radiance. If I'm not on camera, I still wear some makeup," says Beauchamp. "I use concealer, tinted moisturizer and foundation. I also love blushes, fake lashes and lip color. When I'm on camera, it's slightly heavier than what I would do every day."
(Photo: Jesse Grant/BET/Getty Images)
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