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Publications (38)138.04 Total impact
Article: Identification of KCNN2 as a susceptibility locus for coronary artery aneurysms in Kawasaki disease using genome-wide association analysis[Show abstract] [Hide abstract]
ABSTRACT: Kawasaki disease (KD) is often complicated by coronary artery lesions (CALs), including aneurysms. Because of the complications associated with KD, this disorder is the leading cause of acquired heart disease in children from developed countries. To identify genetic loci that confer a higher risk of developing CALs, we performed a case–control association study using previous genome-wide association study data for samples from KD cases only (n=186) by grouping KD patients without CALs (control: n=123) vs KD patients with extremely large aneurysms (diameter>5 mm) (case: n=17). Twelve loci with one or more sequence variants were found to be significantly associated with CALs (P<1 × 10−5). Of these, an SNP (rs17136627) in the potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 (KCNN2) at 5q22.3 was validated in 32 KD patients with large aneurysms (diameter>5 mm) and 191 KD patients without CALs (odds ratio (OR)=12.6, Pcombined=1.96 × 10−8). This result indicates that the KCNN2 gene can have an important role in the development of coronary artery aneurysms in KD.
Article: Outcomes of Mechanical Valves in the Pulmonic Position in Patients With Congenital Heart Disease Over a 20-Year Period[Show abstract] [Hide abstract]
ABSTRACT: Background: Homografts or bioprosthetic valves have been preferred in the pulmonic position in patients with congenital heart disease. However, unsatisfactory long-term results have aroused interest in the use of mechanical valves. In this study, we investigated the long-term outcomes of mechanical valves implanted in the pulmonic position. Methods: The medical records of 37 patients (27 male, 73%) who underwent 38 mechanical pulmonary valve replacements between October 1988 and February 2011 were reviewed, retrospectively. The median age of patients was 13.5 years (range, 7 months to 23 years), and the median number of prior operations per patient was 2 (range, 0 to 5). Tetralogy of Fallot was the most common diagnosis (n=23). The median valve size was 23 mm (range, 17 to 27 mm), and the median follow-up duration after pulmonary valve replacement was 24.6 months (range, 1.3 months to 22.5 years). Events were defined as the following: valve failure, thrombosis, embolism, bleeding, reoperation, and death. Results: There was no in-hospital mortality, but there were 2 late deaths (1 heart failure and 1 traffic accident at 10.8 months and 8.7 years postoperatively, respectively). Excluding the traffic accident death, survival rates were 97%, 97%, and 97%, at 1, 5, and 10 years, respectively. Freedom from thromboembolism or bleeding events was 92%, 92%, and 78.8%, at 1, 5 and 10 years, respectively. Two reoperations were performed at 6.8 and 10.2 years postoperatively. Freedom from reoperation was 100%, 100%, and 85.7%, at 1, 5, and 10 years, respectively. Conclusions: Durability of mechanical valve in pulmonic position was excellent. Thromboembolism or bleeding events due to anticoagulation therapy were rare. In growing patients who have undergone prior sternotomies requiring a pulmonary valve replacement, a mechanical valve could be an attractive option.
Article: The importance of neo-aortic root geometry in the arterial switch operation with the trap-door technique in the subsequent development of aortic valve regurgitation[Show abstract] [Hide abstract]
ABSTRACT: Regarding neo-aortic valve regurgitation (neo-AR) after the arterial switch operation (ASO), the 'trap-door' technique was supposed to be a risk factor due to a distortion of the sinotubular junction (STJ) geometry. Here we report our results of the 'trap-door' technique with a special emphasis on root geometry including the ratio of STJ to annulus. From August 1991 to March 2010, 240 patients with transposition of the great arteries underwent the ASO and who had at least 1 year of follow-up were included in this study. The medical records were retrospectively reviewed. The median age and body weight at the time of operation were 11 (0-1213) days and 3.4 (1.30-18.75) kg, respectively. The median follow-up duration was 79 months (range 12 months-19.5 years). At the latest echocardiographic follow-up, only six patients had neo-AR greater than Grade II (6 of 240, 2.5%). We found no relationship between neo-AR greater than Grade II and perioperative factors. The actual sizes of the neo-aortic annulus, mid-sinus and STJ were observed as having increased over time. However, most z-scores of STJ at the latest echocardiography varied between -2 and 2 and, more importantly, the ratio of STJ to neo-aortic annulus was 0.93 ± 0.20, which was near normal at the latest echocardiographic follow-up. Our results showed a very low incidence of significant neo-AR, which was relatively attributable to the preserved z-score of STJ and the normal range of STJ/annulus ratio. Therefore, we propose that it is important to maintain these factors adequately during the reconstruction of the neo-aortic root in the ASO.
Article: Pulmonary hypertension due to obstructive sleep apnea in a child with Rubinstein-Taybi syndrome[Show abstract] [Hide abstract]
ABSTRACT: Rubinstein-Taybi syndrome (RTS) is characterized by peculiar facies, mental retardation, broad thumbs, and great toes. Approximately one-third of the affected individuals have a variety of congenital heart diseases. They can also have upper airway obstruction during sleep, due to hypotonia and the anatomy of the oropharynx and airway, which make these patients susceptible to obstructive sleep apnea (OSA). In our case, pulmonary hypertension was caused, successively, by congenital heart defects (a large patent ductus arteriosus and arch hypoplasia) and obstructive sleep apnea during early infancy. The congenital heart defects were surgically corrected, but persistent pulmonary hypertension was identified 2 months after the operation. This pulmonary hypertension was due to OSA, and it was relieved by nasal continuous positive airway pressure. This case is the first report of pulmonary hypertension from OSA in a young infant with RTS.
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ABSTRACT: High-dose intravenous immunoglobulin (IVIG) therapy is the highly effective and standard treatment for Kawasaki disease (KD). However, ~20 % of KD patients have persistent fever or recurrence of fever after the initial IVIG treatment, which increases the risk for coronary artery lesions (CALs). Furthermore, the mechanism of IVIG resistance in KD patients still is unknown. The number of CC chemokine ligand 3-like 1 (CCL3L1) gene copies is reported to be associated with KD and IVIG resistance in Japanese patients. In addition, the authors observed significant upregulation of the CCL3L1 gene expression after in vitro immunoglobulin treatment in B cell lines derived from KD patients. Therefore, this study of 459 KD patients and 496 healthy control subjects tested whether the number of CCL3L1 gene copies is associated with a risk of KD, CALs, and/or IVIG resistance in Korean KD patients. However, the number of CCL3L1 gene copies was not associated with KD (P = 0.18), CAL formation (P = 0.062), or the IVIG resistance (P = 0.90). Therefore, the results indicate that the number of CCL3L1 gene copies does not have a role in susceptibility to KD or CALs nor with IVIG resistance in Korean KD patients.
Article: Effectiveness and Safety of Percutaneous Transcatheter Implantation of Pulmonary Arterial Stent in Congenital Heart Disease[Show abstract] [Hide abstract]
ABSTRACT: Pulmonary arterial stenosis is a relatively common complication after corrective operation of congenital heart disease. Unilateral stenosis of pulmonary arteries could result in decrease perfusion of affected lung, pulmonary regurgitation, or elevation of right ventricular pressure. Eventually there are increasing risks of right ventricular failure, arrhythmia, or sudden death. However we have limited data of pulmonary arterial stent in paediatric population as the treatment of branch pulmonary stenosis. This study aimed at validating the effectiveness and investigating complications of pulmonary arterial stent implantation in a single institution during mid-term follow up period. A total of 42 patients (50 stents) were implanted for treating branch pulmonary arterial stenosis. We used cardiac catheterization for comparing diameter after stent implantation directly and lung perfusion scan indirectly. We also investigated any adverse effect relating the procedure. Percent stenosis of stenotic lesions were decreased from 54.1±10.7% to 22.8±12.5% (p<0.001) and degree of decrement in affected lung perfusion was declined from 22.7±8.0% to 10.3±9.0% (p<0.001) immediately and lasts during mid-term follow up period. Complication rate relating the procedure was 12% (6 out of 12) and there was no mortality case. This series showed immediate and short term effectiveness of pulmonary arterial stent in congenital heart defects. We concluded that percutaneous transcatheter implantation of pulmonary arterial stent was safe and effective during short and mid-term follow up period.
Article: Right Ventricular Outflow Tract Stenting in a Low Birth Weight Infant Born With Tetralogy of Fallot and Prostaglandin E1 Dependency[Show abstract] [Hide abstract]
ABSTRACT: Surgical skill and strategy for the correction of tetralogy of Fallot (TOF) have improved and resulted in satisfactory outcomes. However, prematurity and low birth weight continue to remain risk factors for poor outcomes. We present a case of a 2,150 g neonate born with TOF, in whom palliation was achieved with right ventricular outflow tract (RVOT) stenting. Seventy-seven days after the procedure, stenosis of RVOT below the stent was identified. At that time his body weight was 4.9 kg and total corrective surgery was deemed feasible. Eight months following surgical repair, the patient remained well without medical intervention. RVOT stenting may be a viable interim procedure while waiting for a low birth weight neonate born with TOF and prostaglandin E1 dependency to reach optimal weight to undergo corrective surgery.
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ABSTRACT: Kawasaki disease (KD) is the most common cause of acquired heart disease in children. Intravenous immunoglobulin (IVIG) is the standard therapy for KD, but more than 10% of KD patients do not respond to IVIG and are at high risk for the development of coronary artery lesions (CALs). To identify clinical and genetic risk factors associated with CAL development and IVIG nonresponsiveness, this study analyzed the clinical data for 478 Korean KD patients. Multivariate logistic regression analysis showed that incomplete KD, IVIG nonresponse, fever duration of 7 days or longer, and the CC/AC genotypes of the rs7604693 single nucleotide polymorphism (SNP) in the PELI1 gene were significantly associated with the development of CALs, with odds ratios (ORs) ranging from 2.06 to 3.04. The risk of CAL formation was synergistically increased by the addition of individual risk factors, particularly the genetic variant in the PELI1 gene. Multivariate analysis also showed that a serum albumin level of 3.6 g/dl or lower was significantly associated with nonresponsiveness to IVIG [OR, 2.76; 95% confidence interval (CI), 1.34-5.68; P = 0.006]. Conclusively, incomplete KD, IVIG nonresponsiveness, long febrile days, and the rs7604693 genetic variant in the PELI1 gene are major risk factors for the development of CALs, whereas low serum albumin concentration is an independent risk factor for IVIG nonresponsiveness.
Article: Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease[Show abstract] [Hide abstract]
ABSTRACT: Kawasaki disease is a systemic vasculitis of unknown etiology, with clinical observations suggesting a substantial genetic contribution to disease susceptibility. We conducted a genome-wide association study and replication analysis in 2,173 individuals with Kawasaki disease and 9,383 controls from five independent sample collections. Two loci exceeded the formal threshold for genome-wide significance. The first locus is a functional polymorphism in the IgG receptor gene FCGR2A (encoding an H131R substitution) (rs1801274; P = 7.35 × 10 -11, odds ratio (OR) = 1.32), with the A allele (coding for histadine) conferring elevated disease risk. The second locus is at 19q13, (P = 2.51 × 10 -9, OR = 1.42 for the rs2233152 SNP near MIA and RAB4B; P = 1.68 × 10 -12, OR = 1.52 for rs28493229 in ITPKC), which confirms previous findings. The involvement of the FCGR2A locus may have implications for understanding immune activation in Kawasaki disease pathogenesis and the mechanism of response to intravenous immunoglobulin, the only proven therapy for this disease.
Article: Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.[Show abstract] [Hide abstract]
ABSTRACT: Kawasaki disease is a systemic vasculitis of unknown etiology, with clinical observations suggesting a substantial genetic contribution to disease susceptibility. We conducted a genome-wide association study and replication analysis in 2,173 individuals with Kawasaki disease and 9,383 controls from five independent sample collections. Two loci exceeded the formal threshold for genome-wide significance. The first locus is a functional polymorphism in the IgG receptor gene FCGR2A (encoding an H131R substitution) (rs1801274; P = 7.35 × 10(-11), odds ratio (OR) = 1.32), with the A allele (coding for histadine) conferring elevated disease risk. The second locus is at 19q13, (P = 2.51 × 10(-9), OR = 1.42 for the rs2233152 SNP near MIA and RAB4B; P = 1.68 × 10(-12), OR = 1.52 for rs28493229 in ITPKC), which confirms previous findings(1). The involvement of the FCGR2A locus may have implications for understanding immune activation in Kawasaki disease pathogenesis and the mechanism of response to intravenous immunoglobulin, the only proven therapy for this disease.
Article: Is free medical care possible?[Show abstract] [Hide abstract]
ABSTRACT: Free medical care is currently a highly debated issue in Korea. However, from a practical point of view, 'completely free' medical care is impossible. Last year the National Health Insurance Corporation (NHIC) reported a huge deficit of up to 1.3 trillion in Korean won, which is the largest deficit in the past 10 years. NHIC expenditures are skyrocketing for many reasons: drug overuse, very expensive new drugs or devices increasing geriatric population and survivors of cancer or chronic illnesses, expanding insurance coverage for new diagnostic tests, drugs, neonates, rare diseases, disabilities, and cancer, occurrence of new diseases, increasing number of doctors, moral hazard, and wasting of resources due to the duplication and counteraction between modern medicine and Oriental medicine. What, then, should we do to provide partially free medical care? We need to reduce expenditures for drugs and increase health insurance premiums. Korean health insurance premium currently low compared to that of other countries in Organization for Economic Co-operation and Development. It is also necessary to introduce the concept of a health tax, in which healthy individuals with a high income pay higher premiums while sick or low-income individuals pay lower premiums. Expanding public health coverage such as vaccinations, regular health surveillance programs, and education on health promotion should be implemented. Private health care insurance can be introduced carefully with close monitoring. The last and most important recommendation is that society must become more ethical and transparent. Korea is entering a new era as a developed country and as a result a welfare system, including medical care is notoptional but is mandatory in some part. However, even a partially free medical care is going to be possible only if the entire health care system is operated in an ethical and efficient way for maximal utilization of limited resources while avoiding moral hazard and waste.
Article: Low pulmonary vascular compliance predisposes post-Fontan patients to protein-losing enteropathy[Show abstract] [Hide abstract]
ABSTRACT: BACKGROUND: Protein-losing enteropathy (PLE) is a life-threatening and poorly understood complication after the Fontan operation. We sought to determine the pre-operative risk factors for PLE which developed after the extracardiac conduit Fontan operation. METHODS: Two hundred thirty-five patients who underwent the extracardiac conduit Fontan operation as an initial Fontan type procedure (median age at operation: 3.5years) were enrolled in this cross-sectional retrospective study. Pre-operative and peri-operative variables were surveyed through a review of medical records. RESULTS: Within the median follow-up duration of 5years, 12 patients developed PLE (12/234, 5.1%) at a median interval of 2.2years after the Fontan procedure, and 4 died of PLE at a median interval of 1.2years (range 0.21-7.62) after diagnosis. Factors found to be related to the time to the development of PLE on univariate analysis were pulmonary vascular compliance (Cpv) (p=0.0019), central venous pressure at postoperative 12hours (p=0.0026), days of ICU stay (P=0.0449), days of hospitalization (p=0.0135), and days of chest tube indwelling (p=0.0493). Multivariate analysis, however, showed that only Cpv (p=0.0367) remained significant. The range of Cpv was 8.8-26.1mm(2)/m(2)/mmHg (median 17.9) in patients with PLE, and 6.6-122.3mm(2)/m(2)/mmHg (median 26.8) in patients without PLE. CONCLUSIONS: Low pulmonary vascular compliance is associated with the development of PLE after the extracardiac conduit Fontan operation.
Article: Left Ventricular Function After Left Ventriculotomy for Surgical Treatment of Multiple Muscular Ventricular Septal Defects[Show abstract] [Hide abstract]
ABSTRACT: Optimal management of muscular ventricular septal defects (MVSD) is still not determined in the current era. Moreover, long-term left ventricular function after closure of MVSD is not well known. Thus, we investigated surgical outcomes including long-term left ventricular function after closure of MVSD through left ventriculotomy. We conducted a retrospective review of medical records of 20 children who underwent MVSD closure between March 1993 and August 2010. There were 10 boys (50%) and 10 girls (50%). Patient age ranged from 1.6 to 103.4 months (median, 26.4 months), and body weight from 2.8 to 31.5 kg (median, 11.9 kg). Electrocardiogram results were normal sinus rhythm in all except 1 patient with congenital complete atrioventricular block. There were 16 patients who previously had palliative pulmonary artery banding procedures before closure of MVSD. There were 13 patients (65%) with Swiss-cheese type VSD. There was 1 hospital death of a patient with congenital complete atrioventricular block with pacemaker malfunction (5%). There was 1 late death of a patient with del 22q with adenoviral pneumonia. There was no reoperation. Median follow-up duration was 85.9 months (range, 4.7 to 166.7). The location of MVSD was apical portion in 10 patients (50%) and midtrabecular portion in 9 patients (45%). There were 6 Dacron patch closures and 13 direct closures of MVSD through left ventriculotomy. There was no complete atrioventricular block. Last follow-up echocardiographic data showed normal ejection fraction with 65.2% ± 8.2% after closure of MVSDs. There was no leakage in 8 patients; 11 patients had insignificant leakage, which disappeared spontaneously in 4 patients 17.9 months (median value) after operation. Our acceptable long-term results of left ventricular function after left ventriculotomy proved that this technique might be a viable option in the management of MVSD.
Article: Log-transformed plasma level of brain natriuretic peptide during the acute phase of Kawasaki disease is quantitatively associated with myocardial dysfunction[Show abstract] [Hide abstract]
ABSTRACT: Brain natriuretic peptide (BNP) has been considered a biochemical marker for myocarditis in Kawasaki disease. We performed this study to determine its quantitative significance. We attempted to correlate log-transformed BNP concentrations (log-BNP) and clinical, laboratory, and echocardiographic variables in 81 children with Kawasaki disease. Stepwise multiple linear regression analysis was used to determine the variables independently associated with log-BNP concentration. Serum C-reactive protein level (P<0.0001), serum alanine aminotransferase concentration (P=0.0032), white blood cell count (P=0.0030), and left ventricular mass index (P=0.0024) were positively related with log-BNP, and hemoglobin level (P<0.0001), serum albumin level (P<0.0001), Na(+) concentrations (P<0.0001), left ventricular fractional shortening (P=0.0080), and peak early diastolic tissue velocity of the left ventricular basal lateral segment (P=0.0045) were negatively related to the log-BNP concentration. Multiple regression analysis showed that serum albumin concentration (R(2)=0.31, P=0.0098) and left ventricular mass index (R(2)=0.09, P=0.0004) were significantly associated with the log-BNP concentration. Elevated BNP levels during the acute phase of Kawasaki disease may be attributable to cardiac dysfunction associated with the increase in left ventricular mass, and log-BNP concentration may be a quantitative biochemical marker of myocarditis in Kawasaki disease.
Article: Korean Kawasaki Disease Genetics Consortium. A genomewide association analysis reveals 1p31 and 2p13.3 as susceptibility loci for Kawasaki disease[Show abstract] [Hide abstract]
ABSTRACT: Kawasaki disease (KD) is an acute self-limited vasculitis of infants and children that manifests as fever and signs of mucocutaneous inflammation. Coronary artery aneurysms develop in approximately 15-25% of untreated children. Although the etiology of KD is largely unknown, epidemiologic data suggest the importance of genetic factors in the susceptibility to KD. In order to identify genetic variants that influence KD susceptibility, we performed a genome-wide association study (GWAS) using Affymetrix SNP array 6.0 in 186 Korean KD patients and 600 healthy controls; 18 and 26 genomic regions with one or more sequence variants were associated with KD and KD with coronary artery lesions (CALs), respectively (p < 1 × 10(-5)). Of these, one locus on chromosome 1p31 (rs527409) was replicated in 266 children with KD and 600 normal controls (odds ratio [OR] = 2.90, 95% confidence interval [CI] = 1.85-4.54, P (combined) = 1.46 × 10(-6)); and a PELI1 locus on chromosome 2p13.3 (rs7604693) was replicated in 86 KD patients with CALs and 600 controls (OR = 2.70, 95% CI = 1.77-4.12, P (combined) = 2.00 × 10(-6)). These results implicate a locus in the 1p31 region and the PELI1 gene locus in the 2p13.3 region as susceptibility loci for KD and CALs, respectively.
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ABSTRACT: Because perivascular echo brightness (PEB) of coronary arteries has been proposed as a criterion for diagnosis of incomplete Kawasaki disease, we assessed the clinical importance of PEB during the acute phase of disease. We enrolled 58 patients with Kawasaki disease who underwent two-dimensional strain analysis of images of pericoronary tissue taken during the acute and the convalescent phases. Echogenicity of pericoronary tissue and of the blood pool was determined by speckle tracking in the respective areas of imaging as the averages of integrated backscatter over a single cardiac cycle. PEB was defined as echogenicity of pericoronary tissue minus blood pool. PEB did not differ in the acute phase in patients and control subjects (P = .10) and between phases of disease (P = .25). In comparison between patient groups, the presence of pericardial effusion was higher in patients with higher PEB during the acute phase (n = 30) than in the remaining patients (33% versus 4%, P < .01). PEB did not differ between patients and control subjects and is only associated with the presence of pericardial effusion during the acute phase of Kawasaki disease. Our data do not confirm the reliability of PEB as a useful diagnostic sign of incomplete Kawasaki disease.
Article: Molecular Cytogenetic and Clinical Characterization of a Patient With a 5.6-Mb Deletion in 7p15 Including HOXA Cluster[Show abstract] [Hide abstract]
ABSTRACT: Here, we describe the clinical features of a boy with a 5.6-Mb deletion at chromosome 7p15.1-p15.3. He has mild facial anomalies, hand-foot abnormalities, hypospadias, congenital heart defects, and supernumerary nipples. This deletion was detected by array comparative genomic hybridization and verified by fluorescence in situ hybridization using BACs selected from the USCS genome browser. This deletion was not found in subsequent FISH analysis of the parental chromosomes. The deleted region contains several genes, including contiguous developmental genes on the HOXA cluster, which play a role in regulating aspects of morphogenesis during normal embryonic development. The patient's limb and urogenital features were similar to those observed in hand-foot-genital syndrome, which is caused by haploinsufficiency of HOXA13, whereas the congenital heart defect may reflect the deletion of HOXA3. We hypothesized that many clinical features of the patient were due to combined haploinsufficiency of the HOXA cluster. Our study also demonstrates the clinical usefulness of a molecular cytogenetic tool that is capable of detecting imbalances in the genome.
Article: The Outcome of Open Heart Surgery for Congenital Heart Disease in Infants With Low Body Weight Less Than 2500 g[Show abstract] [Hide abstract]
ABSTRACT: Although the outcome of neonatal cardiac surgery has dramatically improved, low body weight (LBW) is still considered an important risk for open heart surgery. The factors contributing to poor outcomes in LBW infants, however, are still unclear. We investigated risk factors for poor outcomes in infants weighing <2500 g who underwent surgical correction with cardiopulmonary bypass (CPB). From January 1995 to December 2009, 102 consecutive patients were included in this study. Median age and body weight at the time of surgery was 19 (range 1 to 365) days and 2.23 kg (range 1.3 to 2.5), respectively. Corrective surgery was performed on 75 infants. The median follow-up duration was 45.03 months (range 0.33 to 155.23). There were 23 (22.5%) hospital mortalities. Emergency surgery and low cardiac output (LCO) were associated with early mortality; however, body weight, Aristotle basic complex score, and type of surgery was not. Early morbidities, including delayed sterna closure, arrhythmia, and chylothorax, occurred in 39 (38.2%) infants. The overall actuarial survival rate at 10 years was 74.95% ± 4.37%. In conclusion, among infants weighing <2500 g who underwent open heart surgery with CPB, perioperative hemodynamic status, such as emergency surgery and LCO, strongly influenced early mortality. In contrast, LBW itself was not associated with patient morbidity or mortality.
Article: Tetralogy of Fallot without the infundibular septum-restricted growth of the pulmonary valve annulus after annulus preservation may render the right ventricular outflow tract obstructive[Show abstract] [Hide abstract]
ABSTRACT: Tetralogy of Fallot (ToF) with infundibular septal deficiency (ISD) is commonly associated with postoperative right ventricular outflow tract obstruction (RVOTO), presumably caused by subpulmonary extension of ventricular septal defect (VSD) and restricted growth of the pulmonary valve annulus (PVA). We sought to determine the postoperative growth of the PVA after annulus preservation according to the presence or absence of the infundibular septum. A retrospective review of 90 patients who underwent surgical repair of ToF between June 1997 and August 2008 was performed. Median age at operation was 9.5 months. Infundibular septum was absent in 15 (15/90, 17%). PVA was preserved in 71 patients (71/90, 79%), including 13 patients with ISD (13/15, 87%). Median follow-up duration was 39 months (2 months to 13 years). There was no early mortality and one late noncardiac death. Among the patients with PVA preservation, reoperation for RVOTO was performed in 4 patients (4/71, 6%), including 3 patients without the infundibular septum. ISD was identified as the only risk factor in reoperation for RVOTO after PVA preservation (RR: 21.85, P = .007). Among the patients who underwent repair with PVA preservation during infancy (n = 43), PVA (Z-score) increased postoperatively in patients with the infundibular septum (+ 0.021/month, P = .009), whereas the changes in PVA (Z-score) were nonsignificant in patients with ISD (-0.021/month, P = .306), with a marginal intergroup difference (P = .056). PVA preservation in ToF with ISD may be associated with a higher risk for postoperative RVOTO, which can be attributed to the restricted growth of the PVA.
Article: Analyses of Left Ventricular Myocardial Deformation by Speckle-Tracking Imaging During the Acute Phase of Kawasaki Disease[Show abstract] [Hide abstract]
ABSTRACT: This study aimed to investigate left ventricular myocardial deformation in children with Kawasaki disease during the acute phase of their illness. A total of 50 patients and 35 normal control subjects were assessed. Data were obtained from the patients during the acute and convalescent phases of Kawasaki disease. Analyses of myocardial deformation [strain (epsilon), strain rate (SR)] was performed using two-dimensional speckle-tracking imaging in three directions (longitudinal, circumferential, and radial) at the basal and mid levels of the left ventricular myocardium. Basal longitudinal epsilon (P < 0.001) and midlongitudinal epsilon (P < 0.0001) were lower during the acute phase of the disease than in the control subjects and associated with serum albumin level and left ventricular mass index (LVMI). Midlongitudinal SR (P < 0.0001) was lower during the acute phase of Kawasaki disease than in the control subjects and associated with LVMI. Decreased systolic SR was not detected in any direction. In conclusion, left ventricular longitudinal systolic epsilon was significantly decreased during the acute phase of Kawasaki disease. This may be a result of myocardial swelling from myocarditis during the acute phase of the disease.
Top Journals
University of Ulsan
Urusan, Ulsan, South Korea
- • Department of Pediatrics
- • College of Medicine
- • Asan Medical Center
Asan Medical Center
Sŏul, Seoul, South Korea
- Department of Radiology
Ulsan University HospitalUrusan, Ulsan, South Korea


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More than three months after Alfred Wright, brother of American Idol contestant Savion Wright, was found dead in East Texas, mystery continues to shroud the circumstances surrounding his death. Was he the victim of a racially-motivated murder? Did his rumored relationship with the white relative of a local law enforcement official have anything to do with it? And what exactly happened in the hours before he was found… Continue reading We Want Justice! Family Of Black Texas Man Found Dead After Relationship With White Woman Offers $30K Reward For Info On The Case
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We Want Justice! Family Of Black Texas Man Found Dead After Relationship With White Woman Offers $30K Reward For Info On The Case
By radio detection and ranging Staff
The search for missing Lisa Irwin was stepped up even more on Friday as $ 100,000 was offered as a reward for information leading to safe return of the Missouri baby, radio detection and rangingOnline.com has learned.
Meanwhile, the private investigator on the case, Bill Stanton, exclusively told radio detection and rangingOnline.com that he is "confident" Lisa will be found.
"If I wasn't feeling hopeful I… Continue reading $100,000 Reward Offered As PI Says He Is 'Confident' Baby Lisa Will Be Found
George Clooney will be recognized for his humanitarian efforts at the Emmy Awards. The Academy of Television Arts and Sciences will present the … Continue reading Emmys to reward Clooney's humanitarian work

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NonConsent/Reluctance Series
NonConsent/Reluctance Series
Small Town SecretsSometimes secrets last a lifetime, some follow us into death.
Smoking Has Its RisksHeather is locked out of the house when having a smoke.
- Parts:
Sniffing Mother-In-Law's PantiesParts:
So Much for My Happy EndingA bitter encounter turns into something else entirely.
So You Want To Share MeA couple explores wife sharing adventures.
SofieOne girl's love of writing gets her violated.
Softball SeductionSarah gets a unique intro to the game of softball.
SoldPrelude: Before the Auction.


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Trip advices lists: 1 - the room facing on the street where I have stayed, is noisy. Down the street there is a traffic light, and you can hear every single vehicle passing by 2- the room was quite clean and smell was ok 3 - parkings are not owned by the hotel, but they are public. You can find... More
Top-rated Attractions Nearby
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Prescription Drugs
Sponsored By
Lawsuit Accuses CVS Of Overcharging For Generic DrugsPharmacy giant CVS is allegedly bilking customers with a deceptive pricing scheme affecting more than 400 generic drugs, claims a Washington, DC-based law firm seeking class action status to recover the cash.
Drug-Related Deaths On The Rise In Westmoreland CountyA drug epidemic is claiming a record number of lives, and officials say there's no sign of a slowdown.
Doctor, Teacher, Corrections Officer Charged In Prescription Drug RingA prescription drug ring is allegedly traced back to an area podiatrist.
Proposed Bill Would Set Up Prescription Drug Monitoring System In Pa.
Ruffsdale Woman Shaken Up During Brazen Home InvasionA local grandmother is still reeling after a man with a gun barged into her home and threatened her life if she didn't hand over her prescription medication.
Are Prescription Drugs Covered Under My Health Insurance?Under the Affordable Care Act, most health insurance policies must cover prescription drugs.
Belle Vernon Doctors Face Charges In Prescription Drug Scheme Three doctors are facing charges in a prescription drug theft scheme at a local chiropractor's office.
Rx Drug Overdose Is Leading Cause Of Unnatural Death In Westmoreland Co.The statistic is shocking: drug overdoses kill more people in Westmoreland County than any other manner of death, besides natural causes.
Couple Charged After Toddlers Eat Prescription Sedatives, HospitalizedA couple is charged with endangering their 2-year-old twins.
Giant Eagle Offering Free Antibiotics If you're feeling under the weather, there's still good news: you can get free antibiotics.
12 Charged In Alleged Prescription Drug RingA dozen people are charged in an alleged prescription drug ring.
American Academy Of Pediatrics Backs New Guidelines For Acne TreatmentAcne is an age-old condition that many teens and older children face, but there are now new guidelines to treat it.


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Kaiju Commissions - Savagala by Bracey100Watch
©2013-2016 Bracey100
Another commission done over at the Colossal Kaiju Combat forums and the 1st of 5 commissions Ive been able to complete out of the 5 I was hit up with at one time! Whew glad to get one off the table so I can justify getting a little sleep, lol. This one was done for and is up for sponsorship on the CKC boards. Check out his bio here: kaijucombat.com/community/inde…
I really like the Aztec part of this creature! Does he tear his enemies' hearts out ??
Nah, Indiana Jones stopped him from doing that any more
Thanks, the Aztec part was my favorite part to draw. From what I understand the lizard half is heroic and the Aztec part is evil or chaotic...so Im sure half of it wants to but is kept somewhat in check.
Well it must suck to have your evil twin sticking out of you But no wonder Aztec part is evil, their culture was possibly the msot bloodthirsty and cruel that ever existed, perhaps that's why it always fascinated me so much
A Basketcase joke comes immediately to mind
Hmmmm.. I don't think i know it
Look it up, its a movie about a guy with a siamese twin who is horribly deformed, and he carries him around in a basket, just look it up
SO fascinating that they were so incredibly advanced and yet so murderous at the same time.
Bracey, the Aztec armor looks amazing. It's exactly how I imagined it would look! I don't think I could have made that look as good as you though, this whole thing is top notch. Very impressive sir.
rather interesting creature
Thanks.He's quite different. I like his design and his bio (check the link).
I saw the bio, pretty interesting concept.
Yeah rather different than your typical kaiju back story. Fun as this is though I cant wait to finish up my commissions to get some more Revamps ans Kaijuverse works done.
You are welcome
Awesome as usual!
that's a CRAZY cyborg!
Actually and I should put his in the description the kaiju is fused with a stone Aztec artifact so its kinda a like a prehistoric cyborg.
Its not really robotic, the one non organic head is actually an aztec artifact
stonemetal, flesh , and motlen fire
nice combo
stonemetal, flesh , and motlen fire
nice combo
Thanks very much, its a crazy design all right.
hos it been? havent heard from u in a while
Wow this design in particular is fucking awesome and the style you did the aztec half of the monster is incredible and full of detail.
Thanks, Im a fan of Aztec culture (I even have the odd human sacrifice on occasion just to make sure the sun keeps working) and I really enjoyed doing the stone idol part of this.
Im glad you like my monster!
Been seeing this guy quite a bit recently, suppose it was only a matter of time before you ended up doing him, huh? Definitely one of my more preferred takes on this guy! Love the magma like limbs contrasting with the more organic body, as well as the stone head.
Really hope this game comes to consoles, I need mai giant monsta fix!
Its a cool design so Im not surprised to see so much fan art. And like you I cant wait for this game, so far there I think they are only shooting for a PC release.
Don't worry! Savagala is up for Sponsorships and I have full intentions of getting him in game!
That's not what I meant XD
While I would like to see him in the game, I said I wanted the game to come to consoles.
Actually CKC is planned to hopefully be on Consoles eventually, at the moment it is a matter of funds, so the better our first release does, the more likely that Consoles will be in the near future
Also, his limbs are made of Magma, that's what the Stone head lets him do
Ok that sounds good, let's hope for the best then. The world seriously needs more giant monster brawlers, we only got ONE this whole generation of consoles. That's no good.
I had a feeling that's how the magma stuff worked. Seems pretty cool.
This makes me actually want to paint my characters, instead of the 3d concepts I'm doing.


text:
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August 7, 2012
Training camp report: Day Two
The Pitt football team was back on the practice field for the second workout of training camp on Tuesday, and the coaches are probably glad to be done with the day's practice, since it was another shorts-and-jersey practice.
Per NCAA rules, Pitt worked in shorts-and-jerseys - no pads - on Monday and Tuesday, and the players will put on shoulder pads for Wednesday and Thursday before donning the full pads on Friday. Naturally, the coaching staff can't wait to get the pads on, but there is still value in these first two days of camp.
"We're here all day," redshirt senior Andrew Taglianetti said after Tuesday's practice. "We have walk-throughs, we have four or five hours of meeting, we're just in our books all the time; it gets to be second nature. I wish I could do that with my schoolwork, because I think I'd be an 'A' student.
"It's definitely tough with all of these installs, but with all the repetitions we're doing, it becomes second nature."
Head coach Paul Chryst acknowledged that these first two days have been "underwear football" - a reporter's words, not his - but it's clear that the lifelong football coach is enjoying the return to daily football practice.
"The great thing about camp is, we get to focus on football the whole time," head coach Paul Chryst. "Along with that, you have to stress them, I think, and force them to grow. It's pain that makes you grow; not that we want to inflict pain on these guys, but you have to stress them. You have to make them work, and I think that's how they grow."
Click here for the full training camp report


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Magellan RoadMate GPS App for iPhone Review
Verdict: Doesn't Take Full Advantage of the iPhone, But It'll Get You To Your Destination
Magellan has been making standalone GPS devices for years. Now the company is hoping to stay competitive in an increasingly smartphone-driven world, and has released an iPhone and iPod compatible version of its popular RoadMate GPS navigation platform.
- Works on the iPhone 4, 3GS, & 3G. iPod Touch (2nd Generation) with optional Premium Car Kit
- $50 App that faithfully brings Magellan's popular RoadMate GPS turn-by-turn software to the iPhone
- Overall sluggishness detracts from an otherwise solid GPS App
Continue reading "Magellan RoadMate GPS App for iPhone Review" »


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wait for me... by this-is-the-life2905Watch
©2010-2016 this-is-the-life2905
"Wait for me...!"
poor mr snail
poor mr snail
luv the snails!!! r those the turkey 1's?? btw, when did u get all these photos up? they seem to hav exploded in number!!
haha yes those are the ones you gave to me xD hm? i haven't put anything up for three or four days?? and I tend to upload four or five at a time :]
They're so cute


text:
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text:
"Where are the PLANES?" her father's commander yelled into his radio from the blood-soaked beachhead. "Send planes or we can't last!" he yelled while Soviet Howitzers decimated his horribly outnumbered men, Soviet tanks closed-in, and his casualties piled up.
Meanwhile "The Leader of the Free World" seemed oddly distracted.
"We must support anti-Castro fighters," these ladies had heard (candidate) Kennedy implore short months earlier during his debates with Richard Nixon. "So far these freedom fighters have received no help from our government," (candidate) Kennedy complained.
Short weeks before the debates CIA chief Allen Dulles (on Ike's orders) had briefed Kennedy about Cuban invasion plans. And since the plans were secret, Kennedy knew Nixon couldn't rebut. And indeed, Vice President Nixon (the invasion's main booster, in fact) bit his tongue. He could easily have stomped Kennedy on it. But to some candidates national security trumps debating points.
"We shall pay any price, bear any burden, meet any hardship, support any friend, oppose any foe, in order to assure the survival and the success of liberty!" these ladies heard from Kennedy mere minutes after he was elected "Leader of the Free World."
Four months later, 1,500 of those very Cuban freedom-fighters that "we must support" were slugging it out 90 miles from U.S. shores against 31,000 Soviet-armed troops, squadrons of Stalin tanks and Castro's entire air force. The beachhead is now known as the Bay of Pigs.
"We will NOT be evacuated!" yelled the commander of these ladies' dads and husbands into his radio. "We came here to fight!" He was responding to the enraged and heartsick CIA man who - upon realizing the magnitude of the betrayal from "The Leader of the Free World.'--was offering to evacuate the Cuban freedom-fighters from the doomed beachhead.
"We don't want evacuation!" roared San Roman back into his radio. "Send planes! Send ammo! We came here to FIGHT!"
The pleas made it to Navy Chief Admiral Arleigh Burke in Washington, D.C., who conveyed them in person to his commander-in-chief.
"Two planes, Mr. President!" Admiral Burke sputtered into his commander-in-chief's face. The fighting admiral was livid, pleading for permission to allow just two of his jets to blaze off a U.S. carrier just offshore from the beachhead and support the desperately embattled freedom-fighters.
"Burke, we can't get involved in this," replied Kennedy, who'd just emerged in a white tux from an elegant ball where he'd twirled a smiling Jackie around the dance-floor, to the coos, claps and twitters of the enchanted crowd.
"WE put those Cuban boys there, Mr. President!" the fighting admiral exploded. "By God, we ARE involved!"' But Admiral Burke could not budge The Leader of the Free World from betraying his pledge to the freedom-fighters desperately battling Soviet Imperialism 90 miles from U.S. shores.
The freedom-fighters were expending their last bullets as Lynch again offered to evacuate them. But San Roman again responded: "No!--This ends here!", his response was barely audible over the deafening blasts from the storm of Soviet artillery.
"Can't continue," crackled the final message from San Roman a day later. For three days his force of mostly volunteer civilians had battled savagely against a Soviet-trained-and-led force 10 times theirs' size, inflicting casualties of 20 to 1. To this day their feat of arms amazes professional military men. "They fought magnificently—and they were NOT defeated!" stressed their trainer Marine Col. Jack Hawkins, a multi-decorated veteran of Bataan, Iwo Jima and Inchon. "They simply ran out of ammunition after being abandoned by their sponsor the U.S. Government."
Morale will do that to a fighting force. And there's no morale booster like watching Soviet proxies Fidel Castro and Che Guevara ravage your homeland and families, believe me.
Ammo finally ran out. "Russian tanks overrunning my position," reported San Roman on his radio... "destroying my equipment." Finally the radio went dead.
"Tears filled my eyes," writes CIA man Grayston Lynch, a multi-decorated WWII and Korea vet who trained and befriended the Cuban freedom-fighters—and took their final message. "I broke down completely," writes the Silver Star-winner who carried scars from Omaha Beach, Bastogne and Korea's Heartbreak Ridge. "For the first time in my 37 years I was ashamed of my country."
If instead of the above, it requires Mimi Alford's tabloid-gossip for some to finally feel ashamed of their nation's "leader" of the time…well, better (half-a-century) late than never.
Humberto Fontova holds an M.A. in Latin American Studies from Tulane University and is the author of four books including his latest, The Longest Romance; The Mainstream Media and Fidel Castro. For more information and for video clips of his Television and college speaking appearances please visit www.hfontova.com.
Rush Limbaugh defends Rubio's debate answer: He's absolutely right that Obama knows what he's doing | Allahpundit
Time for Team Hillary to break out the gender card for young liberal women who prefer Sanders | Allahpundit


text:
Search Results for The Aviator
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8 Things You Never Knew About 'Top Gun'
Only The Strong Survive" in the film. Adams, however, declined because he felt as though the film glorified war. 4. In addition to popularizing Ray-Ban aviator sunglasses and bomber jackets, the film also helped boost Navy recruitment
'Top Gun 2′ Is Reportedly In Development With Tom Cruise
Grab your favorite pair of aviator sunglasses, because we're about to go from the highway to the sequel zone! According to The Daily Mail , Top Gun 2 is in development, and will feature Tom Cruise returning to the role of skilled but troubled
The First Trailer For 'The Little Prince' Will Add Some Much-Needed Magic To Your Week
though, introduces a new main character, The Little Girl (Mackenzie Foy), who lives with ..... neighbor, an eccentric old man known as The Aviator (Jeff Bridges). From there, she quickly discovers the story of The Little Prince, and — as you do
20 best pop culture-themed Halloween costumes
Photography If you're searching for the most adorable Halloween costume ..... inspired outfit. Via Twisted Sifter The South Pa rk gang's all here ..... Check. Baby in sling wearing aviator sunglasses? Check. This Hangover ..... Trades This crafty mom created the entire Taylor Swift look for just
cranking out two dozen titles in the early 2000's, The Aviator and The Departed standing out among them. You thought ..... Superman , Test Drive , the amazing spider - man , The Aviator , The Bourne Legacy , the dark knight rises , the departed
Leonardo DiCaprio and Martin Scorsese have teamed up again for The Wolf of Wall Street which will be their fifth film together. Which of their previous collaborations is your favorite?
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Leonardo DiCaprio and Martin Scorsese will team up again in the new film The Wolf of Wall Street . Which movie the two have collaborated on is your favorite?
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Production continues in Vancouver on the Warner Bros. superhero adventure Superman: Man of Steel, which is slated for release June 14, 2013. A new crop of set photos has appeared, which feature Kevin Costner between takes on a farm in the Delta area of Vancouver. Take a look at these photos below for your latest look at Superman: Man of Steel and the new Pa Kent.
Man of Steel was released June 14th, 2013.


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The Adorable Spider by DitchmasterWatch
©2012-2016 Ditchmaster
Critiques please! My first finished animation, everything is mine except the audio which came from the 11 Second Club. I would love to get some feedback on what I can do to make it better before it goes into my demoreel. Enjoy!
this is amazing
this is amazing
this spider is so cuute good work ,i love it
I enjoyed this, even though spiders are not my favorite. It's cute, and whimsical. There is something about the hair that appears very stiff and corse. did you mean to do it that way?
Haha yes, because spider hair isn't like fluffy animal fur. Although I might change it in the future if I use the rig again.


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carisoprodol/aspirin - oral, Soma Compound (cont.)
PRECAUTIONS: Before taking this medication, tell your doctor or pharmacist if you are allergic to carisoprodol or aspirin; or to meprobamate, tybamate, or mebutamate; or to nonsteroidal anti-inflammatory drugs-NSAIDs (such as ibuprofen); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: a certain blood disorder (acute intermittent porphyria), asthma (including a history of worsening breathing with runny/stuffy nose after taking aspirin or other NSAIDs), growths in the nose (nasal polyps), stomach/intestine/esophagus problems (such as bleeding, heartburn, ulcers), bleeding/clotting disorders (such as hemophilia, von Willebrand disease, thrombocytopenia), personal or family history of regular use/abuse of drugs/alcohol, kidney disease, liver disease, seizure, certain enzyme deficiencies (such as G6PD or pyruvate kinase deficiency), gout.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages.This medicine may cause stomach bleeding. Daily use of alcohol and tobacco, especially when combined with this medicine, may increase your risk for stomach bleeding. Avoid alcohol and stop smoking. Consult your doctor or pharmacist for more information.This medication contains aspirin. Children and teenagers less than 18 years old should not take aspirin if they have chickenpox, flu, or any undiagnosed illness or if they have recently received a vaccine. In these cases, taking aspirin increases the risk of Reye's syndrome, a rare but serious illness.Older adults may be more sensitive to the side effects of this drug, especially drowsiness, confusion, stomach/intestinal bleeding, and ulcers. Drowsiness and confusion can increase the risk of falling.This medication is not recommended for use during pregnancy. If you become pregnant or think you may be pregnant, tell your doctor immediately. Do not use this medication during the last 3 months of pregnancy because of possible harm to the unborn baby or problems during delivery. Consult your doctor for more details.This medication passes into breast milk and may have undesirable effects on a nursing infant. Therefore, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.
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UFC 111 background: Hardy a 'control freak'
British mixed martial artist Dan Hardy explains his mindset in the lead-up to his contests, and how he has prepared to meet GSP, the champion, who defends the UFC welterweight belt in Newark, NJ, today.
In an exclusive interview, Hardy tells The Daily Telegraph of his self-belief in a contest in which many have him slated as a rank outsider. The Canadian is considered one of the top pound for pound fighters in the world, and in many people's books, sans pareil as a mixed martial arts athlete.
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March 3rd, 2015 18:43


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Hi Birdyberth,
Could you please explain how you are able to have the ECG wave display smoothly when plugged in to a digital pin? I thought that continuous data ie ECG wave must be plugged into the analog pin?
Any education would be great!
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Home > News > Tamil Nadu News
Posted on Jan 30, 04:32PM | IBNS
Chennai, Jan 30 : The Madras High Court on Wednesday stayed the release of Kamal Haasan's Vishwaroopam, a film that ran into trouble over its alleged content that has been branded as anti-Muslim community.
The film will not release in Tamil Nadu till Feb 6 after the stay order since the bench set aside the interim order by a single bench judge of the same court a day ago, apparently paving its release.
The Madras High Court on late Tuesday had lifted the ban on Vishwaroopam in Tamil Nadu. The verdict was passed by Justice K Venkataraman after a day-long hearing on Tuesday.
But the Tamil Nadu government appealed against the verdict in a double bench, defending the ban in order to maintain "communal harmony".
According to reports, the judge, who saw the film over the weekend earlier, had asked Hassan to explore the possibility of an amicable settlement with the government.
Reports said Kamal Haasan has agreed to delete some scenes and words in reach an out of court settlement with the groups protesting its release.
Kamal Haasan earlier on Wednesday said he would leave Tamil Nadu and India if required to stay in a secular place to just remain an artist who is godless.
"I want to stay in a secular state. I will find another state other than Tamil Nadu from Kashmir to Kerala to stay. If I do not find I will stay in another country which is secular," he said in an emotional press conference here, adding that he has mortgaged his entire property to the financier of the film and would lose it all.
"I want to be a secular man. I want to stay where these things do not touch me," he said. "M F Hussain-saab [late painter] had to go out of India for the same reason. I am just an artist. I am godless. I am fed up," he said.
"I shall wait for the afternoon judgement [a verdict in his favour has been challenged again in a higher bench of Madras High Court] but after this I think I will have to seek for a secular state to stay in from Kashmir to Kerala excluding Tamil Nadu. I will look for a place which would house an artist, I will pay for it. I know my art is still left and I can earn."
He said he will hopefully find another country which is secular to stay if he cannot find a place in India. "Nothing will change the fact that I am a Tamil and an Indian. Only my passport will change," he said.
"I wonder how one movie could knock this mighty nation's unity," he said.
He said nothing was clear to him why these things were happening to him and said the fact is that he was yet to get interim relief or order and film shows were stopped again.
"I believe that along with my Muslim friends I have been an instrument in a political game. I do not know who is playing it and I am not even hazarding a guess. The fact remains that my history has proven that I have been never leaning to the left or right," he said.
India's Censor Board chief Leela Samson said Kamal Haasan is being hounded since the film has been cleared by the board and only then it was set for release.
Actor Farooq Sheikh said Kamal Haasan must sue the government for damages since they had cleared the film through Censor Board first and then stopped its release.
"The judge in a previous report said one man's money is not more important than the unity of the nation and I agree," said Haasan. He said he has bequeathed all his property to the person who put his money on the film.
Haasan on Thursday had moved the Madras High Court and filed a petition after the Tamil Nadu government banned the screening Vishwaroopam for 15 days. The court, on the same day, ruled that the movie could not be release till at least Monday.
The Rs 95-crore movie was supposed to be released on Friday before running into opposition by groups protesting its "anti-Muslim content" and was banned by the government.
Tamil superstar Rajinikanth came out in support of Haasan and urged Muslim groups in Tamil Nadu to help him release Vishwaroopam.
"I am very upset about the developments in the Vishwaroopam issue. I have known Kamal for 40 years now. I know Kamal would not hurt anyone. From the very fact he showed the movie to Islamic community says he respects them," Rajinikanth said in a statement.
The Tamil superstar urged Muslim 'friends' to "sit with Haasan and discuss the issue and allow its release without affecting its storyline".
The state government banned the film after Muslim groups objected to its screening after a special screening for them.
The film was not screened in other south Indian cities such as Hyderabad and Bangalore on Friday.
Vishwaroopam is written, directed and co-produced by Haasan that features him in the lead role.
The film also has Pooja Kumar, Rahul Bose, Andrea Jeremiah and Jaideep Ahlawat in supporting roles.
The film was shot in many locations, including largely in USA, while sets resembling Afghanistan were constructed in Chennai.


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text: 1. (a) Is the following association a function? Explain why or why not. Pick a 3-digit positive integer with all three digits different. Reverse the digits to get another 3-digit number. Subtract the smaller number from the larger to get another positive number. If the difference is less than 100, insert leading zeros so you have three digits (e.g., 71 becomes 071). Reverse the digits of the difference and add it to the difference to get a final 3-digit number. 2. (a) Write an algebraic expression for the Magical Birthday Calculation Function defined by the following sequence of algebraic operations: � Enter the number 7 � Multiply by the month of your birth � Subtract 1 � Multiply by 13 � Add the day of your birth � Add 3 � Multiply by 11 � Subtract the month of your birth � Subtract the day of your birth � Divide by 10 � Add 11 � Divide by 100 (b) If the association is not a function, draw a frowning face as your answer. If the association is a function, what are its domain, its codomain, and its range?


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Gaming enthusiasts can look forward to some serious gaming this summer as Etisalat launches the new Sony PlayStation 4, attractively bundled with a year's membership of PlayStation Plus.
The new offer is available to Etisalat's new eLife package subscribers on a flexible monthly instalment of AED79 for 24 months. Alternatively, customers can purchase it up-front for AED1899 from any Etisalat Outlet across the country.
Etisalat's PlayStation®4 bundle is aimed to provide gamers in the UAE a rich online multi-player gaming experience on the company's high-speed broadband network. As well as new games with rich, high-fidelity graphics, the PS4 system opens the door to an incredible journey through immersive new gaming worlds and a deeply connected gaming community.
Membership to PlayStation®4 Plus gives customers access on PS Vita, PS3 & PS4. It includes Instant Game Collection® with top rated titles every month on PSVita, PS3 & PS4, on-line multiplayer gaming on PS4, one hour full game trial on selected titles before purchase; early access to demos and priority beta invites, discounts and special offers in PlayStation® Store, cloud Storage for game saves and automatic system software and game updates for PS3.
Rashed Alabbar, Vice President of Home Product Marketing, Etisalat, said, "We're soon approaching summer holidays for children in the UAE. Etisalat's new PS4 deal could be a great treat for children and an ideal gift to celebrate the end of their academic year. It offers dual advantage of the gaming console as well as a year's membership of PlayStationPlus at an attractive price point not available anywhere else in the UAE."
With an astounding launch line-up and over 180 games in development, the PS4 system offers more top-tier blockbusters and inventive indie hits than any other next-gen console. The PS4 system learns how you play and intuitively curates the content used most often. Users can broadcast their gameplay live and direct to the world, complete with commentary. The PS4 is the best place to play with dynamic, connected gaming, powerful graphics and speed, intelligent personalization, deeply integrated social capabilities, and innovative second-screen features.
Combining unparalleled content, immersive gaming experiences, digital entertainment apps and PlayStation®4 exclusives, the PS4 system focuses on gamers, enabling them to play when, where and how they want.


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|solidturtleman .
Nov 03
That One Time: The SwapperThat One Time is a series of articles, each of which analyze a specific moment from a different video game.� � SPOILERS FOR THE SWAPPER The automated voice echoes, "Hull breach in Sector 1. All personnel to Waste Man... 0
|solidturtleman .
Apr 02
Nitpicking? A Little Rant about Bioshock: Infinite (SPOILERS)SPOILERS FOR BIOSHOCK: INFINITE BELOW Approximately halfway through Bioshock: Infinite, Booker and Elizabeth must travel from their current reality, in which a group of rebels called the Vox Populi is futilely attempting t... 0
|oliverf1234 .
Dec 04
Review: Lego Lord of the rings (All consoles)Lego Lord of the rings This game is a amazing experience for Lego fans and fans of the Lord of the rings series And yes, The Lego people talk during cut scene just like in Lego batman 2 This game doesn't have a Main plot, ... 0
|oliverf1234 .
Nov 19
Review: Limbo (pc)Limbo is a Dark, Disturbing, Masterpiece its 2D sidescroller fits perfectly with its puzzle based genre Every thing about this game is brilliant, its smooth animation, its black and white visuals and its surprising gameplay.... 0
|solidturtleman .
Oct 01
So Capcom's selling... human flesh to promote RE6?Man, I don't know what to say. I mean... displaying edible human in public is just awesome. Sharon Baker, has been hired by Capcom to alter the look of London's Smithfeld Meat Market to that of a human flesh trade market.... 0
|solidturtleman .
Aug 23
Team Ninja Wants to Make Metroid: Other M 2 (*sigh*)In a Gamescom interview with Dead or Alive 5 director Yosuke Hayashi VG247 discovered the most horrifying fact I've heard in a while: The possibility of Metroid: Other M 2 being born into this world exists. Upon being aske... 0
|solidturtleman .
Aug 06
Source 2 Info Foundhttp://www.valvetime.net/threads/exclusive-next-gen-source-2-engine-is-in-development.215336/ Valve Time, a somewhat credible fan site, has just found files for Source 2 in the Source Filmaker. Here's a direct quote from So... 0
|solidturtleman .
Jun 26
Wrath of Lamb: Is it Good?I just wanted to know how it was in comparison with Binding of Isaac? Is it worth getting? :D 0


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I'm visiting family and haven't had my probiitic for three days, and yesterday I ate pizza for the first time in months along with cookies and popcorn, etc.
Today I'm battling some serious tummy pain and diarrhea (sry for TMI). I have been popping peptos, drinking water and Gatorade and eating crackers, light soup.
Anyone have any suggestions? This is my old method but I'm sure mamas crunchier than me have some ideas. Worried LO will get some ill effect through BFing


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Are evangelicals, of all the religious communities in America, the most in need of science education?
That would seem to be the take-away if you attended a national conference held in Washington, DC, on March 13, 2015, as I did.
Sponsored by the AAAS Dialogue on Science, Ethics, and Religion (DoSER), the well-attended presentations claimed to be concerned primarily about the conflicting views that the religious and scientific communities tend to have of one another. One religious community, however, was singled out for special attention: evangelicals. more >>
Each of us must decide what to do with each day. In this fast-moving age of digital information we are constantly bombarded with urgent appeals for help. Appeals become a veritable digital deluge, a flood of electronic chaos that threatens to drown us in misery. Deciding which problems are genuine is not the most difficult challenge. No, the difficulty is to discern which we might reasonably take on and hope to make a difference.
The digital age has reduced the size of the world. Problems that were distant, in another land, are now brought to our digital doorstep. Given the velocity of information in the digital age, we are flooded not only with legitimate but also with many illegitimate demands for action. Environmental crises loom large in the modern consciousness. However, our perception of crisis is most often not the product of personal experience. Instead, it is a product of media designed to play on our hopes and fears.
This world is full of real problems. But in today's climate we are more than ever liable to be swept along by expertly crafted narratives that stretch truth and swell our inboxes. How then can one determine which of our perceptions of reality are true, and which are fear mongering? more >>
In the account of the Exodus, God's people had a bright future ahead of them, if they only would trust in the Lord and lean not on their own understanding.
The days of wandering in the desert aren't too different than the days we inhabit. Then like now, the cultural challenges seemed stacked against us. Then like now, God still has more to do with each of us, yet many evangelicals are calling for a return, a return to Egypt, a return to separation from the culture.
In the book of Numbers we find the account of Caleb. Moses through God led the Israelite refugees through Sinai to the edge of "The Promised Land." He then sends twelve men to explore this land of milk and honey. After 40 days, they return. One, Caleb, sees the hope for a better future. The others are fearful and cause the people to cry out, "If only we had died in Egypt." more >>
Late last year a group of evangelical environmentalists associated with the Office of Social Justice (OSJ) of the Christian Reformed Church, after returning from visiting Kenya, were featured in a series of videos titled "Climate Conversation: Kenya in which they say poor Kenyans are suffering from reduced rainfall caused by manmade global warming.
"It's unfortunate, but farmers all over Africa are talking about changing weather patterns," says Dr. Dennis Garrity, Director General, World Agroforestry Center, U.S.A. "There has been enormous changes in the onset of the rainy season, the length of the rains, the duration and the intensity of drought during the rainy season. And it all fits the scientific evidence that Africa is in fact the area of the world that is going to suffer the most from climate change."
Craig Sorley, Care of Creation Director for Kenya, explains, "Farmers in the past, when I was a young man, always say the rains were so predictable. And now the rains have become very unpredictable. They are playing a guessing game as to when the rains are going to arrive." more >>
Did manmade global warming cause the Syrian civil war and the rise of ISIS?
A new paper, Climate change in the Fertile Crescent and implications of the recent Syrian drought, PNAS, March 2, 2015, summarized its findings by saying, "the 2007-2010 drought contributed to the conflict in Syria. It was the worst drought in the instrumental record, causing widespread crop failure and a mass migration of farming families to urban centers."
It went on to say, "Century-long observed trends in precipitation, temperature, and sea-level pressure, supported by climate model results [emphasis added], strongly suggest that anthropogenic forcing has increased the probability of severe and persistent droughts in this region, and made the occurrence of a 3-year drought as severe as that of 2007-2010 2 to 3 times more likely than by natural variability alone." more >>
Earlier this week, I wrote about Dr. James Enstrom's successful settlement of his lawsuit against UCLA. Long a dissenter against environmentalist scare-mongering, Dr. Enstrom sued UCLA officials (full disclosure: my colleagues and I at ACLJ represented him) after they fired him shortly after Dr. Enstrom discovered that new California regulations of diesel emissions were based on junk science advanced by a scientist with a fraudulent degree — a doctorate purchased from the fictional "Thornhill University." Dr. Enstrom also discovered that the scientific review panel tasked with reviewing this science was stocked with ideologues who'd long overstayed mandatory term limits.
The case was hard-fought, with the university filing two motions to dismiss, followed by lengthy and grueling discovery. While the issues were largely constitutional (did the university fire Dr. Enstrom because of his constitutionally protected speech?), the constitutional dispute was motivated by a sharp "scientific" disagreement over the health danger of diesel particulate. I use the scare quotes because UCLA's actions hardly reflected scientific ideals. Here's an interesting excerpt from a deposition with Dr. Enstrom's dean at the time of his termination (the questioner is an ACLJ lawyer):
Q: Okay. Do you have a general knowledge with regard to Dr. Enstrom's research regarding diesel particulate matter? more >>


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Around the remote: 'Animation Domination'
|Mandy Moore (AP Photo/Dan Steinberg, file)
Viewers will be treated to a sneak preview of two 15-minute programs airing under the edgy new late-night block Animation Domination High-Def," starting with "Axe Cop."
It's the tale of an insomniac superhero (voiced by Nick Offerman) who gets just two minutes of sleep a night and eats only birthday cake. It's followed by "High School USA!" in which Mandy Moore and Vincent Kartheiser supply the voices of perky students. 9:30 p.m. Sunday, Fox.
(Animation High-Def officially premieres July 27).
SUNDAY: On "Drop Dead Diva," Jane (Brooke Elliott) represents a star basketball player. For his sake, let's hope she's got game. 9 p.m., Lifetime.
MONDAY: Better be on your toes for Season 2 of "Breaking Pointe." The unscripted series about the inner workings of a ballet company resumes as the dancers begin auditions for "Cinderella." 9 p.m., The CW.
MONDAY: "Supermarket Superstar" is a "Shark Tank"-like reality series that has home chefs pitching their recipes to food industry titans for a chance to have their creations put on the shelves of a major grocery chain. 10 p.m., Lifetime.
TUESDAY: "The Vineyard" could be some lightweight summer fun. It's a "docu-soap" that follows a group of young hotties as they work, frolic and hook up along the shores of Martha's Vineyard. 10 p.m., ABC family.
TUESDAY: Time to hit the couch. "Web Therapy" is back in session for Season 3 as kooky shrink Fiona Wallace (Lisa Kudrow) welcomes an array of new guests, including Steve Carell, Meg Ryan, Billy Crystal, Chelsea Handler and old "Friends" co-star Matt LeBlanc. 11 p.m., Showtime.
WEDNESDAY: Brace yourself for "Spell-Mageddon." It's a game show that challenges contestants to spell increasingly difficult words while dealing with distractions like getting dunked in a tank or doused in slime. 9 p.m., ABC family.
THURSDAY: She may be super fast, but Sanya Richards-Ross can't run from the cameras. In "Sanya's Glam & Gold," the Olympic track star puts her life with her husband, NFL player Aaron Ross, on display for all to see. 10 p.m., WEtv.
THURSDAY: The delightfully sick comedy, "Children's Hospital," returns for more Adult Swim absurdity. How absurd? The new season has the doctors holding a wine-tasting during an operation. The police procedural parody, "NTSF:SD:SUV::" immediately follows. Midnight, Cartoon Network.
FRIDAY: The mesmerizing period drama, "Magic City," continues with Ike (Jeffrey Dean Morgan) again crossing ethical boundaries. This time, he initiates a scheme to rig the Cuban lottery. 9 p.m., Starz.
SATURDAY: You may want to watch "American Haunting" with the lights on. It's a new series that delves into the tormented lives of families experiencing paranormal activity in their homes. First up: A Kentucky residence where strange voices are being heard. 8 p.m., A&E.
— Contra Costa Times
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Left or right?!
This was a transvaginal ultrasound at 6w, 3 days. Baby and yolk sac look to be on the right but I have circled the placenta (white bulky area) which looks to be to the left and they say its placenta location so I am even more confused! Any guesses would be so appreciated!


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Bar, Yoga Studio, Coffee Shop at Jefferson L stop
Everything. I love this place!
I love this bar, you can get drunk the night before and get coffee in the morning and work from your computer. Bartenders & baristas are always nice and music is great!
great music. drinks. pool. buck hunt. and a random comedy show in the back on fridays
Love the new back room!
Dough donuts and a full bar
Just like it's patrons, switches from hot coffee during the day to dive bar by night. Come by on Tuesdays for free-to-play trivia night, with prizes that include a $20 bar tab if you win.
Snappy hour
Delicious Coffee in the morning, Booze in the Evening, Yoga downstairs. Perplexing. Endearing. Super friendly owners, you'll always feel incredibly welcome immediately upon walking in.
Check out Cobra Club as seen on Best Bars in America Read more
Shiner on draft!
World class comedy every Friday for free!! Happy hour ends right before the show starts. Lovely staff. You can't beat that with a stick...
Does not serve food anymore.
Joanna is the hottest barista here. Great coffee.
Longhaired rockers will appreciate the fierce dryers in the bathroom, which can double as blowouts if you left the house with wet locks. So I've heard.
This is my favorite bar in Brooklyn. I only wish other places would use the friendly atmosphere here as a model for their own establishments. Brush your shoulders off Cobra.
Low-key coffee shop (and yoga studio) by day, fun and lively bar by night; Cobra Club's a great neighborhood joint, regardless of the hour.
Heard about this place on Weekend Update
Cobra club is a great laid back bar/coffee shop that serves donuts from Dough (great donut shop located in Bed-Stuy).
It has a duke box and beer. Hits the spot.
Just got Buck Hunter and a pool table...SWEET!! (July 2013)
Now with 100% more Big Buck Hunting!
Say hi to RunAround Sue! And give her a hug!
Excellent Counter Culture coffee in the A.M.
Good drinks and staff and great snacks (jerky, donuts, frito pie oh my) Only con, for those trying to work most of the tables wobble.
Devil Lock: Jalapeño infused vodka, fresh lime, OJ, agave, tobasco.
Misfits cocktails 'Nuff said
Best coffee in the area!
I have a serious urge to write "Joyce Carol Oates Sux" on the bathroom wall. # yogastudioandbar
The coffee in the morning is great when you're sober. The Frito Pie in the evening is great when you're drunk. The coffee the next morning is great when you're hung over. Wash, rinse, repeat!
Although they use Counter Culture Coffee here & have good equipment, preparation isn't the best. Food, free wifi, & outdoor space make this a good work spot, and the bar makes an ideal standing desk. Read more
Come on Sundays when the Pats are playing and watch Nikki shout @ the screen while housing Frito pie.
Best punk rock jukebox
The owners are two rad babes! Totally support this place! Yummy food, breakfast treats, dogs and BBQ night! And the drinks are slammin'... My go to spot for a good time.
If you bring your laptop, grab a seat by the front window. That's where the outlets are.
Great place, amazing coffee. This is my new go to study spot
I like the drinks specials during happy hour, the no frills coolness and the good tunes.
Such amazing coffee, super nice bartenders, and a really fun cocktail menu. My new neighborhood go-to spot.
Great jukebox. They offer Snap and Root. Has major potential!
Just go here. Amazing.
Best yoga slash whiskey bar in town.
God bless Bushwick
Just got their liquor license. My new favorite bar!
Love the space and the coffee ROCKS!!!! cold brewed people!!!! GO
#4 dog, fritos and chilly
Cute coffee shop and bar! Lots of space and even outdoor seating!
Counter Culture coffee served here.
Best coffee in Bushwick.


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Pronunciation: /juːnɪˈpəːs(ə)n(ə)l/
Definition of unipersonal in English:
Comprising or existing as one person only: during the war, Franco had laid the foundations of his unipersonal command
More example sentences
- Her question marks the limitations of Charmichael's vision and critiques Proust's unipersonal narrative style.
- The Great Depression with its accompanying economic crisis led to a civilian coup in the early 1930s, which returned the country to a unipersonal presidency.
- The narrative structure used in the first two segments of 'Time Passes' alludes to Proust's unipersonal technique.
Definition of unipersonal in:
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EZ Chill Air Conditioning Extension Hose
The EZ Chill Air Conditioning Extension Hose is designed with both safety and effectiveness in mind, ensuring that any difficulty in reaching A/C charging points is completely eradicated. Charging can take place with the component attached to an Interdynamics trigger & gauge while the person using it can stand clear from hot or moving components on the vehicle.
EZ Chill Air Conditioning Extension Hose Extra Info
- 90 degree simple connection allows access to low side charging ports at inaccessible angles
- Automatic shut off valve reduces refrigerant leakage during charging and air ingress
- Heavy duty metal connector improves product longevity
- Length: 24 inches
Please be aware that this product must not be used on hybrid vehicles.
Additional InformationPlease be aware that this product must not be used on hybrid vehicles.
EZ Chill Air Conditioning Extension Hose - 24 inch
Cat code: 344686
Free Click & Collect
Delivery not available
- Free refrigerant level check.
Air con recharge only £30 & re-charge and clean only £40
Other customers who bought this also viewed
ReviewsEZ Chill Air Conditioning Extension Hose - 24 inch 4 4Does what it's supposed to.... Relieved to find this existed after buying the original kit and not being able to reach the lower port. Just a shame the original hose isn't this long or this is included when you buy the kit. 26 August 2014rubbish it di not fit properly on the car. this is all I can write 20 July 2013Required item but a little expensive This is a must item if you plan to recharge your car as most access points are in the most awkward places. 06 July 2013Don't be fooled by the picture The hose is simple, it does exactly what it says on the packet - it is an extension hose. It you need to get better access to the low side port on the AC system then this is a useful addition to the self-fill system. If you can access the port and there is space to hold the refill can this extension is unnecessary. For a short length of hose with two brass fittings is it not good value for money. ***Take care, it does NOT include the trigger and gauge as displayed in the picture - is is ONLY the extension hose*** 07 May 20131-4 of 4
Other Buying Options
You can buy this product from one of our carefully selected Approved Partners. The full list of options available are below. Simply add your chosen option to your basket and proceed to checkout when you're ready.
You can purchase products supplied by Halfords and selected other suppliers on halfords.com.
Checkout is always via halfords.com and all payment will be taken via halfords.com. In checkout the products will be split into separate deliveries for each supplier.Showing 1 - X of our buying options
Price Seller Info Purchase


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BISOUS MAGAZINE accepts submissions from emerging photographers, fashion film directors, artists, musicians, bloggers, writers, fashion brands and designers. If accepted, your work can be featured on our website, magazine or both. All submission guidelines can be found below.
WEBITORIALS Bisous magazine accepts short fashion editorials with or without clothing credits from emerging photographers for consideration to be placed on our website. Please send at least 8 images low res in an assortment of clothing choices at least 4 as we need a total of 5 panoramic fields filled with either panoramic or vertical shots next to each other. Please include team credits to firstname.lastname@example.com with Webitorial in the subject line. Models must be agency represented to be considered. All other disclosure rules apply.
SPRING ISSUE FASHION EDITORIAL DEADLINE MAR 1st, 2016 ABSOLUTELY NO EXCEPTIONS.
We are always accepting webitorials for weekly postings. And Friday Face submission of your favorite model test.
SPRING ISSUE will be our RETROFITTED issue
Please note this is a MOODBOARD of collective images to use as examples from photographers across the world and are not or will not be published in the magazine.
Yep it's our RETRO issue. This however doesn't mean using all VINTAGE clothing. Designers across the boards have embraced styles and form from the past in their collections this Spring and we want to see your adaptation on a 'retro' feel. Whether that be in creative direction, styling, execution or post the images should convey a feeling from the past in a modern fitting way. As always, we want The WOW factor. Clothing Creds still stand true and only SPRING/SUMMER/RESORT 2016 or Couture collections will do. Bring on the CREATIVITY. PLEASE ONLY AGENCY REPRESENTED MODELS. Submit at firstname.lastname@example.com
Photographers the stakes are becoming increasingly higher so bring your A game and make sure you choose your faces wisely S/S 2016 collections. Tasteful nudity is fine. . You must use different Designers. IT MUST TELL A STORY or it's just a test. Celebrity pitches welcome.
COVERS Every photographer's submission is considered for the cover so choose your models with this intention and don't forget to shoot a COVER SHOT to be considered. Remember if chosen Bisous Magazine has the right to adjust stories accordingly including renaming it, changing order sequence, color adjustments and cropping when needed.
Any content you submit to BISOUS must not be published in any other magazine, blog, webzine, facebook, online anywhere else without permission. If you post this work anywhere, prior to submitting to us and/or after BISOUS has published your work (in print or online), we reserve the right to pull the story from our editorial line-up without your consent. BISOUS permanently has publishing rights to any submissions.
Stylists we will no longer print Vintage as a clothing option. Use this as an opportunity to contact PR companies current collections ONLY with limited pieces of TARGET, ZARA, H&M. One designer is not an editorial it's a lookbook and we will NOT publish it in the issue. We only provide pull letters to those who have been published with us in the past.
1) "Stylist's own" IS NOT A BRAND or DESIGNER.
2)Must have 8 different wardrobe changes to be considered for an editorial within the magazine with LIMITED Designer repeats.
3)Models must be agency represented.
We look forward to seeing what everyone has to contribute. For those of you returning …Thank you so much for making our last year so fabulous!
Full Disclosure: By allowing BISOUS Magazine to publish your work, you grant us permission to use your work without compensation in any of our publications, websites, marketing material, advertisements, videos, and any other mediums or formats used in the creation, dissemination, and production of BISOUS Magazine content. This includes models, by consenting to your image to be submitted within an editorial, webitorial or advertorial feature you are giving Bisous Magazine the permission to use your image without compensation. Photographers please note that if accepted and published you are giving photo and art department the permission to disseminate, alter and title your story as they see fit in keeping with the feel and branding of the magazine. If you have any artistic disapproval we will kindly remove the story for you.
How to be considered:
Send an e-mail to firstname.lastname@example.com with LOW RESOLUTION images attached do not embed.(72dpi under 500kb each), links to music and/or .doc files with the following information:
- name
- website
- city, state, country
- short biography (optional)
- team credits / clothing credits
- models must be agency represented no exception
- (photographers only send up to 12 images)
WE WILL THEN SEND YOU AN ACCEPTANCE LETTER WITH INSTRUCTIONS FOR HI-RES IMAGES. ALL IMAGES ACCEPTED MUST HAVE HI-RES 300 dpi for our print option
Writer/Blog Submissions
DEADLINE FOR WRITTEN, FEB 29, 2015. Writers please submit your pitch before the deadline so that we may approve it. Drafts must be submitted by FEB 29 to ensure publication.
At BISOUS magazine, we are always looking for guest writers and bloggers who would like to contribute to the magazine and website. If you are interested in writing for us, please send us an an email with the headline Writer or Blog submission and include a writing sample or links to some of your work/blog. Some of the topics we cover include music, culture, art, artist and designer interviews, trending fashion, and fashion technology. We love people who are creative, lively and hilarious. You are more than welcome to pitch ideas. We also like highlighting those things in which we love and could easily chose your blog to feature.
If selected this is what we need from you:
type: .doc
image name: your name/issue#/sectiontitle/storytitle.doc
minimum of 150 words maximum 900
Editorial Feature Sections we're interested in you submitting for
WE LISTEN section covering music or emerging artists which are relevant to the issue
WE WATCH section covering new film releases or books we should give a try
WE JETSET section covering escapes, secret hideaways, restaurants and nightlife
WE DIG IT section covering emerging designers
WE COVET section covering new trends and must haves
WE ENCOURAGE this section covers young emerging creatives
WE ENHANCE section covering beauty tips or secrets
WE OBJECTIFY one image editorial dedicated to a hot actor/model/or just hot guy.(think Maxim for cool chicks)
WE TASTE food section
WE ENTERTAIN party planning ides
WE SHOCK pushing boundary category
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text: TROPHY CASE Trophy Case: December's Best Local Stuff This month's winning finds, from Genki-Su drinking vinegar to community-supported soap 12/2/2013 at 9:00am This article appeared in the December 2013 issue of Portland Monthly Magazine. Filed under Portland Band, Trophy Case Show Comments Sign up for newsletters! Home and garden tips, inside intel from Portland Monthly's fashion editor, and more from Portland's rich design scenes.


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Business |
European stock index futures signal lower start
LONDON Nov 20 European stock index futures pointed to slightly lower open on Tuesday, pausing after the biggest daily gain in 10 weeks, with a downgrade of France's credit rating capping sentiment.
At 0702 GMT, futures for the Euro STOXX 50, Germany's DAX and France's CAC were all 0.3 percent lower.
Our top photos from the last 24 hours.