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Search results for 'BACKPACK'
ULTIMATE SURVIVAL TECHNOLOGIES: Wet Fire Tinder (8 cubes)$7.95The perfect accompaniment to any fire starter, WetFire can help you get a blaze going even in a downpour. In fact, the cubes actually burn longer when wet!8 individually wrapped cubes. MADE IN THE USA. (blister carded) -Pack of 8 cubes Learn More
Black Diamond Orbit Lantern
Regular Price: $29.95
Special Price: $20.97Black Diamond Orbit Lantern is a light 60 Lumen lantern perfect for once conscious backpackers. The LED dual reflector system and frosted globe can illuminate the tent and your predawn racking. A pocket-sized version of our popular Voyager, the Orbit is a bright, ultra-lightweight lantern crossed with a powerful flashlight—making it perfect for trekking or backpacking where shaving grams is crucial. Bright and ultra-packable, the Black Diamond Orbit Lantern is a pocket-sized collapsible lantern crossed with a powerful flashlight for versatile, travel-friendly lighting. A lightweight version of our popular Voyager, the Orbit features a super-bright DoublePower LED in a frosted globe for 60 lumens of power in latern mode, and a DoublePower LED in the bottom for 50 lumens of power in flashlight mode. The Orbit also functions in dual mode for near-360-degree lighting for cooking, reading and other camp activities. The dimming function allows you to adjust the light to your needs, while the collapsible design stores easily in your pack. Learn More
MAMMUT: Adelina T-Shirt Women's
Regular Price: $49.00
Special Price: $24.50This T-shirt is a new and lighter weight addition to our Dri-release® collection. It is faster drying, even during very sweaty activities, and ensures comfortable heat exchange. Optimally suitable for: Multipitch Rockclimbing, Sportsclimbing, Mountain Hiking Suitable for: Walking, Via Ferrata, Travel, Gym Climbing, Backpacking Learn More
MAMMUT: Candela T-Shirt
Regular Price: $49.00
Special Price: $24.50This T-shirt is a new and lighter weight addition to our Dri-release® collection. It is faster drying, even during very sweaty activities, and ensures comfortable heat exchange. Optimally suitable for: Multipitch Rockclimbing, Sportsclimbing, Mountain Hiking Suitable for: Walking, Via Ferrata, Travel, Gym Climbing, Backpacking Learn More
Mammut: Men's Mica T-Shirt
Regular Price: $59.00
Special Price: $29.50The Mammut Men's Mica T-Shirt is a climbing t-shirt made of quick drying synthetic with a natural feel and raglan sleeves. Learn More
GSI: Crossover Kitchen$34.95This kit was made to fit within nForm Crossover cook sets. Contains the new pivot utensils, scraper, bottles, cutting matt, spice shaker, scrubbing pad and towel all in a half moon module. Learn More
Mammut: Men's Snow Zip Longsleeve
Regular Price: $75.00
Special Price: $37.50The Mammut Men's Snow Zip Longsleeve Top is a great midlayer for skiing and snowboarding. This top has a soft and warm inside and a durable and fast-drying outside. You'll be hitting the slopes with comfort in this midlayer top's soft polyester and elastine construction. Learn More
MAMMUT: Yampa Pull Women
Regular Price: $79.00
Special Price: $39.50Mammut Yampa Pull is a sporty fleece pullover with fashionable Mammut embossing - a young jacket for travelling. Optimally suitable for: Via Ferrata, Backpacking, Classical Alpinism Suitable for: Travel, Sportsclimbing, Mountain Hiking Learn More
RAB: Aurora Pull On
Regular Price: $79.95
Special Price: $39.98The RAB Aurora Pull On is the ideal mid weight pull on. Super light weight (8 oz) yet incredibly weather resistant. The Aurora Pull on will be your favorite to keep you warm on cold summer days and winter ascents. Winner of Backpackers Editors Choice Award with breathability and superb wind and weather protection. Learn More
Nemo: Morpho 2P Pawprint
Regular Price: $59.95
Special Price: $41.97The Pawprint is a removable liner for the inside of your tent. It has the double function of protecting your tent floor from boots and paws and of adding serious comfort. The Pawprint is made of a machine washable, brushed fabric that is very soft to the touch. Place your sleeping pads underneath to help them stay in place. With a clean, soft Pawprint under you, you might be able to save some weight and travel with a lighter sleeping bag or blanket. Learn More
Ibex: Pulse Runner Short - Brief
Regular Price: $84.95
Special Price: $42.48No chafing, pinching, or bunching in these comfortable classics from Ibex. With a soft Merino internal brief that stretches and moves with you, the Pulse Runner has got you covered, literally. Throw them on for miles in the woods, multi-day backpacking trips, or a quick 10k; these shorts thrive on high mileage adventures. Pulse Our Pulse fabric is designed to lend a bit of stretch to Merino wool. Made for high output activity like trail running and yoga, Pulse is a lightweight blend of Merino fiber and spandex for a softer feeling active garment. Pulse improves the benefits of wool to fit, feel and perform better. 96% Merino Wool, 4% Spandex Fiber Source: New Zealand Where the fibers of this fabric are sourced. Fabric Source: New Zealand Where the fibers are knit or woven into this fabric. Garment Source: United States Where the fabric is assembled into this garment. Learn More
CRAZY CREEK: The Original Chair - Royal Blue$44.00Crazy Creek's most popular and versatile chair. Convenient handles for easy carrying. Hook and loop straps to keep chair folded closed during transport. 420D coated ripstop nylon.The Large Chair is 2"" wider for more expansive comfort. Learn More
Mammut: Men's Snow Longsleeve Shirt
Regular Price: $98.00
Special Price: $49.00The Mammut Men's Snow Longsleeve shirt is a light long-sleeved cotton shirt with Lycra® stretch and fashionable print. Learn More
Nemo: Zor/Tuo Standard 1P Pillow Top
Regular Price: $79.95
Special Price: $55.97The Nemo Zor/Tuo Standard 1P Pillow Top has vertical and horizontal coring which minimizes weight and packed size while still providing insulation. Zor packed size will leave you plenty of room for other backpacking essentials. For extra insulation, the ultralight Zor Pillowtop includes a soft jersey cover and a 1" foam insert. Ultralight fabric allows Zor to pack smaller and weigh less. Learn More
GSI: Pinnacle Hiker$59.95Amazingly compact design is built around the needs of 2 Gourmet Hikers who are still concerned with weight. Modular design can be extended to meet any Gourmet Camping needs. Color-coded items made of Infinity clear polypropylene provide personalized tableware settings.* *Exclusive folding gripper locks on to exterior brackets to prevent scratching and to provide a secure handle while cooking. Unique design compacts for nested storage. Crushproof strainer lid made of BPA-Free resin prevents deformation of your pot/lid and works with either the pot or the frypan. Mesh stuff sack keeps set organized. Learn More
MAMMUT: Rundle Jacket Women
Regular Price: $129.00
Special Price: $64.50Soft shell made from very breathable and soft material - ideal for warmer climates. Optimally suitable for: Via Ferrata, Backpacking, Approach Suitable for: Walking, Basecamp, Mountain Hiking Learn More
MAMMUT: Savoy Jacket Women
Regular Price: $129.00
Special Price: $64.50Mammut Savoy Jacket: Very light, cosy fleece jacket with sporty, colour-contrasting flatlock seams. Optimally suitable for: Skitouring / Backcountry Skiing, Freeriding / Boarding, Alpine Skiing Suitable for: Backpacking, Classical Alpinism Learn More
GSI: Pinnacle Dualist$64.95Crushproof lid made of BPA-Free resin prevents deformation of your pot/lid and includes an integrated strainer. Convenient folding handle locks into place for cooking and secures entire set for transport, eliminating the need for a stuff sack. Unique bowl + mug solution with low center of gravity and Sip-It virtually eliminates spills while the integrated insulating sleeve keeps your drinks hot. Ingenious, welded stuff sack holds set while traveling and doubles as a sink or wash basin in camp. Learn More
Mountainsmith: Red Rock 25$69.00The most versatile of the three day packs for cross-over activities such as day-hiking, snowshoeing, bike commuting, school use or as an airline carry-on. This feature rich day pack is as comfortable on the tarmac as it is on the trail. Made with 450d recycled PET, the Red Rock 25 utilizes 15 recycled 16-ounce plastic bottles. Save the planet, go backpacking! *Special Note - Sangria Color - shoulder harness ergonomically fit specifically for women. Learn More
Mammut: Men's Yukon Trim Jacket
Regular Price: $138.00
Special Price: $69.00The Mammut Men's Yukon Trim Jacket is a light, comfortable fleece pullover with zipped collar; a faithful companion for all outdoor activities. Learn More
MAMMUT: Savoy Hoody Women
Regular Price: $139.00
Special Price: $69.50Mammut Savoy Hoody: A very light, cosy fleece jacket with a hood featuring sporty, colour-contrasting flatlock seams. Optimally suitable for: Skitouring / Backcountry Skiing, Freeriding / Boarding, Alpine Skiing Suitable for: Backpacking, Classical Alpinism Learn More
Mammut: Men's Elias Jacket
Regular Price: $149.00
Special Price: $74.50The Mammut Elias Jacket is one of the lighter soft shell jackets, and its 430-gram weight combined with its high degree of breathability make it a good choice for shoulder-season actvities and warm(er) temperatures. The Mammut SOFtech fabric is quite stretchy, soft, and comfortable. Learn More
Mammut: Men's Yadkin Jacket
Regular Price: $158.00
Special Price: $79.00The Men's Mammut Yadkin Jacket is a sporty fleece pullover, that is light weight and can be worn as a baselayer or on it's own Learn More
MAMMUT: Felici Jacket Women
Regular Price: $159.00
Special Price: $79.50Good value for money soft shell - developed for the mountains and everyday wear. Optimally suitable for: Via Ferrata, Backpacking Suitable for: Walking, Basecamp, Mountain Hiking Learn More
Mammut: Women's Cengalo Jacket
Regular Price: $159.00
Special Price: $79.50The Mammut Women's Cengalo Jacket is a climbing soft shell that fulfils every wish - developed for uncompromising multi-pitch climbing. Learn More
Black Diamond: Distance Cork Trekking Poles
Regular Price: $119.95
Special Price: $83.97Black Diamond Distance Cork Trekking poles combines the versatile Distance Z-Pole with a natural, moisture-wicking cork grip, the Distance Cork is ready for active endeavors from trail running to backpacking. Durable all-aluminum construction is matched with a coated inner cord and our innovative speed cones for deployment in just seconds while on the trail. Breathable straps wick away sweat, and non-slip mini grip extensions allows for quick choke-ups on steep uphill sections. Interchangeable rubber and carbide Tech Tips can be easily swapped out for different trail surfaces. Learn More
MAMMUT: Arctic Jacket Women
Regular Price: $179.00
Special Price: $89.50Mammut Arctic Jacket is warm and sporty - thanks to the high-quality POLARTEC Thermal Pro™ material, the Artic Jacket Women is the perfect combination for protective ski jackets. Optimally suitable for: Mountain Hiking, Freeriding / Boarding, Alpine Skiing Suitable for: Backpacking, Winterhiking / Snowshoeing Learn More
Mammut: Women's Rash Jacket
Regular Price: $179.00
Special Price: $89.50The Mammut Women's Rash Jacket is an ultra lightweight jacket, with Gore Windstopper® fabric that keeps you comfortably protected from town to trail. The jacket is lightweight, and with the anatomically cut GORE-TEX® WINDSTOPPER® Soft Shell, it is excellent for mountain sports and backpacking: perfect breathability combined with optimal weight. Learn More
Black Diamond: Demon Backpack
Regular Price: $129.95
Special Price: $90.97The Black Diamond Demon Pack is a streamlined cragging and multi-use pack that will survive years at the crag and on the trail. For comfort and stability when you're on the move, it features a removable aluminum stay and framesheet and a padded waistbelt. The main compartment holds ample gear for day trips and the zippered top-loading panel has a guidebook pocket for quick route references. Four compression straps, a tuck-away rope strap and an ice axe/trekking pole loop round out the package. Learn More
Mountainsmith: Centennial$99.00The most technical ruck in our day pack line, ideal for such activities as day-long climbing, pushing a 14er summit, or that get-away fly fishing trip. The slim profile expands to provide an astonishing 38 L of capacity for those extra long days avoiding the rat race. Made with recycled PET, the Centennial 30 utilizes 16 recycled 16-ounce plastic bottles. Save the planet, go backpacking! Learn More
MAMMUT: Plana Jacket Women
Regular Price: $199.00
Special Price: $99.50Mammut Plana Jacket is a functional Soft Shell made from two different fabrics, offering perfect functionality for both alpine use and everyday wear. Optimally suitable for: Skitouring / Backcountry Skiing, Winterhiking / Snowshoeing, Bouldering Suitable for: Walking, Backpacking, Classical Alpinism Learn More
Mammut: Men's Wing Half-Zip Jacket
Regular Price: $200.00
Special Price: $100.00The Mammut Men's Wing Half-Zip Jacket is built to be extremely light and packable, this pullover will have you breathing a sigh of relief when you pull it out after the weather starts to head south when you're halfway up a multi-pitch project Learn More
Treksta: Evolution Mid Gtx
Regular Price: $159.90
Special Price: $103.94Winner of the prestigious 2011 Backpacker magazine Editors' Choice Award, the Evolution Mid GTX is the ultimate 4-season hiker. With the unrivaled comfort of NestFIT and the technical additions of Gore-Tex waterproofing and an ultra-sticky HyperGrip/IceLock sole this mid-hiker will keep you and your feet happy no matter the conditions. Learn More
TREKSTA: EVOLUTION MID GTX Womens
Regular Price: $160.00
Special Price: $104.00Winner of the prestigious 2011 Backpacker magazine Editors' Choice Award, the Evolution Mid GTX is the ultimate 4-season hiker. With the unrivaled comfort of NestFIT and the technical additions of Gore-Tex waterproofing and an ultra-sticky HyperGrip/IceLock sole this mid-hiker will keep you and your feet happy no matter the conditions. Learn More
MAMMUT: Ultimate Pro Advanced Jacket Women
Regular Price: $219.00
Special Price: $109.50New improved classic: a comfortable GORE-TEX® WINDSTOPPER® soft shell material for a jacket that is also idea for everyday wear. Optimally suitable for: Via Ferrata, Mountain Hiking, Backpacking Suitable for: Walking, Travel, Classical Alpinism, Winterhiking / Snowshoeing, Approach Learn More
Mammut: Men's Stratus Hooded Jacket
Regular Price: $220.00
Special Price: $110.00The Mammut Men's Stratus Hooded Jacket, is an insulated jacket which stuffs into its own front pocket. Learn More
Black Diamond: Speed 40 Backpack
Regular Price: $159.95
Special Price: $111.97The Black Diamond Speed 40 is the go-to pack for light, alpine-style ascents on rock or ice. The Speed is a streamlined, strippable climbing pack with reACTIV suspension. The strippable, streamlined alpine pack is ideal for fast-paced ice and rock missions, the Speed features a removable hipbelt, lid and framesheet for a comfortable yet minimalist carry for your on-route essentials. Ice-tool attachments, a tuck-away rope strap and ladder-lock crampon straps secure all your technical gear on the approach. Learn More
ZAMBERLAN: TREKKER RR Women's$112.50Specifically lasted for women, Zamberlan's 308 TREKKER RR WNS is built for comfort on the trail and specifically for those who appreciate a traditional leather-lined boot with modern amenities. The 308 Trekker RR is built on the Vibram® Ananasi platform, allowing for excellent shock absorption with enough support to handle a 40 pound pack. Encased in 2.4mm waxed Tuscan leather and protected up front with Zamberlan's RRS (rubber-reinforcement-system) and lined with leather and Cambrelle® for moisture wicking, the 308 Trekker RR has the looks and performance of an instant classic. USE: Lightweight and durable tough hiker and moderate backpacker for warm, dry climates. Learn More
Patagonia: Women's Alpine Guide Pants
Regular Price: $229.00
Special Price: $114.50Patagonia Women's Alpine Guide Pants are up for remote ski tours, névé-filled corners and coarse granite alike, with a super-durable, highly breathable Polartec® Power Shield® stretch-woven blend (nylon/polyester/spandex) with Hardface® Technology that dramatically improves the DWR (durable water repellent) finish's resistance to wind, water, snow and abrasion. Detailing includes a harness-friendly, flat-lying waist with an adjustable, built-in belt; a zippered fly; one thigh and two handwarmer pockets (all zippered); articulated knees and a brushed interior for next-to-skin comfort. Midweight reinforcement fabric on the knees and lower legs protect against ski edges, crampons and the patented mixed-climbing knee-scum. The gusseted, 2-snap position bottom cuffs zip open wide to accommodate ski and expedition boots but also have an elasticized gaiter-style cuff with tie-down loops, for a snug fit over alpine boots. Learn More
Black Diamond: Axis 33 Backpack
Regular Price: $169.95
Special Price: $118.97The Black Diamond Axis 33 is built to handle it all, from clipping in Catalunya, alpine summits above Zermatt and splitter cracks in the Utah desert—life as a climber can cover a lot of ground. Designed with the same versatile, guide-style platform as the Epic packs with a zippered top opening in place of a lid, the Axis features the ergoACTIV suspension system to move with you whether you're approaching the crag or carrying the pack on route. Learn More
Black Diamond: 50 Caliber Backpack
Regular Price: $169.95
Special Price: $118.97The Black Diamond 50 Caliber is a cavernous, top-loading cragging pack with a unique "stand up" haul bag-style bottom for easy loading. Padded shoulder straps, a removable dual-density hipbelt and a 20 mm aluminum stay frame provide support and comfort for long approaches. Learn More
Black Diamond: Epic 35 Backpack
Regular Price: $169.95
Special Price: $118.97The Black Diamond Epic 35 is a super versatile pack, one climbing pack to do it all. This pack is built to handle the full 365 days of sunny rock routes, frigid icefalls and foreboding alpine faces. This guide-style, top-loading pack employs our ergoACTIV suspension system, which uses an active, pivoting hipbelt for dynamic, responsive movement over variable terrain. Ice-tool PickPockets™ and ladder-lock crampon straps secure your technical gear on the approach and the descent. Learn More
Patagonia: Men's Solar Wind Jacket
Regular Price: $249.00
Special Price: $124.50Patagonia Solar Wind Jacket is ideal on those cold windy winter days. Conserve your heat and stay dry, with this highly warm and breathable jacket. Solar Wind Jacket is made from Gore Windstopper shell and Primaloft Eco-friendly recycled polyester insulation. Simple embeded cord locks made for quick adjustments and hand warmer pockets designed for harness and backpack use will make any alpinist pleased. Learn More
Patagonia: Women's Solar Wind Jacket
Regular Price: $249.00
Special Price: $124.50Patagonia Solar Wind Jacket is ideal on those cold windy winter days. Conserve your heat and stay dry, with this highly warm and breathable jacket. Solar Wind Jacket is made from Gore Windstopper shell and Primaloft Eco-friendly recycled polyester insulation. Simple embeded cord locks made for quick adjustments and hand warmer pockets designed for harness and backpack use will make any alpinist pleased. Learn More
ZAMBERLAN: STEEP GT Women's$135.50The 760 STEEP GT WNS represents innovation and fresh Italian design with award-winning comfort straight out of the box. Ideal for backpacking, hiking, adventure travel or as an everyday boot for those on their feet all day. Handcrafted from premium Hydrobloc®-treated Italian nubuck leather with double stitching for improved durability, the 760 Steep GT features a waterproof breathable Gore-Tex® liner and the exclusive new Zamberlan Vibram® StarTrek® sole to provide superior lateral support and ankle protection as well as stability and traction on uneven terrain. Features the Zamberlan Ladies Fit. USE: Zamberlan's most comfortable and award-winning backpacking boot is ideal for both on-trail and off-trail use in the most extreme conditions. KEY FEATURES: 2010 Backpacker Magazine Editor's Choice Award 2010 Backpacker Magazine Best All Around Boot Learn More
MAMMUT: Masara Jacket Women
Regular Price: $280.00
Special Price: $140.00Mammut Masara Jacket is technically refined DRYtechTM Premium jacket with laser cut pockets reinforced with Gorilla Tape. The outer material features feminine embossing. Optimally suitable for: Expeditions, Backpacking, Classical Alpinism Suitable for: Skitouring / Backcountry Skiing, Multipitch Rockclimbing, Mountain Hiking, Winterhiking / Snowshoeing Learn More
WESTCOMB: CRUISER LT Hoody Women
Regular Price: $380.00
Special Price: $152.00Westcomb Cruiser LT Hoody Women is totally waterproof, breathable, compressible, and lightweight. A backpacker's dream. The Cruiser LT is the ultimate rain and wet climate shell. Constructed of waterproof-breathable eVent® technology, this piece is engineered for optimal protection and comfort across a wide temperature range, when every gram counts. Weight matters. At Westcomb, we understand. Your journey begins in the warm low-lying plains and ends at the cool glacier-crusted summit. Lightweight and compressible, the Cruiser LT will provide wet weather protection on your epic backpacking trip regardless of the forecast. - Construction with 260NR eVent® rip-stop nylon throughout the body and underarms ensures minimal weight with total water and wind protection in this versatile shell. - The hood, shoulders, and upper arms are reinforced with 560NST eVent® nylon fabric; protecting those high-impact zones from friction and wear caused by pack straps, or low-lying branches. - The broad brimmed, adjustable, helmet-compatible hood efficiently sheds water away, keeping your face dry and vision clear during hard downpours. - The high collar up top, and the longer cut in back provide full body coverage when the rain goes horizontal. - The underarm venting zippers open to cool you down during a humid summer rain. - 2 Roomy hand pockets, perfect size and placement keeps your must-reach gear right at your fingertips. A Napoleon pocket is strategically placed to clear your backpack's waist belt for easy access on the trail. - Micro-taped seams ensure waterproof integrity throughout the entire piece. The elasticized cuffs and trim fit minimizes unnecessary bulk, yet the cut is roomy enough to layer under for added warmth as the temperature drops with the setting sun Learn More
Black Diamond: Mission 50 Backpack
Regular Price: $219.95
Special Price: $153.97The Black Diamond Mission 50 is a super-durable pack outfitted for the demands of winter cragging and alpine climbing. The Mission's reACTIV XP suspension allows the pack to move with you while stabilizing big loads on the approach. The pack's 50-liter capacity swallows your ropes, rack, layers and other essentials while the ice-tool PickPockets™ and exterior crampon pouch secure your sharp things. The Mission 50's padded hipbelt is also removable for streamlining on alpine routes. Learn More
Westcomb: Women's Bolt Jacket
Regular Price: $479.95
Special Price: $191.98The Bolt is Westcomb's full-featured Polartec® NeoShell® mountaineering jacket, designed specifically for women in the backcountry. Hiking, backpacking, skiing, or climbing, if you do it, this jacket will be there with you. Waterproof. Windproof. Amazing breathability. Ready to handle the myriad of possible alpine conditions you expect to encounter on your next expedition. Learn More
Black Diamond: Mirage Tent
Regular Price: $299.95
Special Price: $209.97The Black Diamond Mirage Tent is a lightweight shelter for weight-conscious backpackers and climbers, the Mirage is our lightest 2-person tent. Designed with ounce-counting climbers and backpackers in mind, the Black Diamond Mirage features a streamlined construction that dispenses with the unnecessary extras in favor of lightweight, 3-season performance. A single door and integrated vestibule make for easy entry and gear storage, while the fast-pitch pole hub makes setup a breeze. And when light isn't light enough, the Mirage's fly and optional ground cloth combine to make a streamlined shelter. BD's lightest, strongest 2-person double-wall tent Fast-pitch hub, variable-diameter DAC Featherlite® poles Built-in vestibule 1500 mm polyester fly and 2000 mm nylon floor Freestanding design Can also be set up using just the fly, poles and optional ground cloth (sold separately) Learn More
Black Diamond: Mesa Tent
Regular Price: $329.95
Special Price: $230.97The Black Diamond Mesa Tent is a 2-person double-wall tent that's ideal for any camping or backpacking trip, the Mesa features a lightweight yet spacious design. Primed for weekend car camping or extended backpacking trips, the award-winning Mesa tent features a versatile 2-person, double-wall, 3-season design that strikes an ideal balance between low weight and livability. Two doors and two vestibules provide individual entry and storage, while the fast-pitch pole hub makes for quick and easy set up when a storm rolls in. When you're looking to go really light, the Mesa's optional ground cloth (sold separately) and rain fly function as a streamlined shelter. 2-person, double-wall, 3-season design with 360-degree mesh views Fast-pitch hub, variable-diameter DAC Featherlite® poles for efficient space Double doors and 2 integrated vestibules 1500 mm polyester fly and 2000 mm nylon floor Can also be set up using just the fly, poles and optional ground cloth (sold separately) Learn More
Nemo: Women's Rhapsody Down Sleeping Bag
Regular Price: $349.95
Special Price: $244.97Nemo Women's Rhapsody Down Sleeping bag has the perfect combination of comfort and trail performance. Extra room at elbows and knees accommodates all of you sleeping positions without adding unnecessary weight. Unlike conventional mummy shapes, our new Spoon™ Shape backpacking bags give you extra space where it matters most. Wide in the elbows, the bag tapers down to the hips then gently flares back out to allow room for your knees to naturally bend and shift throughout the night. This innovative bag profile offers true sleeping comfort while maintaining thermal efficiency and low weight. Details like a fully adjustable contoured hood with Pillow Pocket, tuckable Blanket Fold™ and a Waterproof/Breathable footbox elevate comfort and protection for adventures near or far. Learn More
ZAMBERLAN: VIOZ GT$256.00Hydrobloc® full grain on a plain, simple and effective upper design - Zamberlan® exclusive Vibram® 3D sole for great grip, exceptional cushioning, wear resistance and traction - GORE-TEX® lining for utmost protection and breathabilty - Microtex wicking nylon collar lining help control excess moisture - Zamberlan® Rubber Reinforcement System enhances protection to the upper. USE: Extended backpacking, long trekking, four season hikes. Learn More


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I have a lot of unsweetened baking chocolate. What's the correct ratio of sugar to add if I want to use it like semi-sweet?
For baking chocolate, use 1 square (1 oz.) of unsweetened chocolate plus 1 tablespoon of sugar in place of 1 square (1 oz.) of semi-sweet chocolate
Just be aware that semisweet chocolate has a special silkiness to its texture, and unsweetened+sugar won't be quite as smooth or glossy when melted. It'll still taste great, of course!
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Pretty Awesome Weekend
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Tuesday, September 25, 2012
I know it's Tuesday but I wanted to blog about my weekend! Just been a busy bee but I have a few minutes right now so here I am!
Friday, DS, DH and I drove to a little town about 40 min away from home for dinner. It is an award winning bbq place
don't worry I had a kids meal, water and just a few bites of bbq ribs off of DH plate. So all in all not too bad. In my past life I would have devoured rib after rib, side dishes, dessert, cocktail or a beer and who knows what else! We had our dinner on the patio and the weather and sunset could not have been more beautiful! After dinner we stopped by the mall to get my sonny boy some new shoes, so I walked off some of the calories lol. I did get a Starbucks coffee at the mall but no major calorie damage.(gotta have it!)
Saturday we had another fun day with the hubs and the kiddo. Out to breakfast @ panera (I know lots of eating out but got their low cal breakfast sandwich and coffee) We went garage sale shopping after that the weather again was awesome! Went home and relaxed for a while, later that evening we went to a friends she had a party for her sons' baptism, had dinner there small portions;) 1 cocktail, and stayed a little while then headed off to a "double date" with my DH's cousin and his wife (DS in tow lol) we went to play miniature golf it was fun no hole in ones this time
Sunday DH had to work so it was just the boy and I at home lots of cleaning and prepping stuff for the week. Then headed to my moms house for dinner...I brought a cucumber salad and filled most of my plate with it and just small portions of everything else. Drank lots of water the entire weekend so although I could have done a little better it went pretty well.
So here I am on Tuesday making turkey/black bean chili for dinner, planning to go to zumba tonight! Have an awesome day sparkly peeps! :)
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Sounds like a great weekend!
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Wow! I love active weekends especially when the weather is gorgeous! Glad you had a great weekend!
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De-Constructed Chicken Cordon Bleu
Total Time
Prep 20 mins
Cook 40 mins
EASY! I found a recipe (or idea) from Paula Deen, and switched up a few things to suit myself. It is much simpler than original cordon bleu and the flavor is GREAT! I use country (salty) ham, as that is what I prefer...you may substitute your favorite deli ham, of course....This is great for company and pretty quick to throw together...so tasty, and they'll think you worked for hours!
Ingredients Nutrition
- 4 chicken breasts
- 1 cup all-purpose flour
- 1⁄2 teaspoon garlic salt
- 1⁄2 teaspoon kosher salt
- 1⁄2 teaspoon fresh ground pepper
- 2 eggs, beaten
- 1⁄2 cup milk
- 1 cup breadcrumbs
- 1 1⁄2 teaspoons italian seasoning
- 1 cup parmesan cheese, grated
- 1 tablespoon olive oil
- 1 tablespoon butter
- 4 slices country ham
- 4 slices baby swiss cheese
- Preheat oven to 350°F.
- Pound chicken breasts flat.
- Combine flour, garlic powder, kosher salt and pepper in shallow pan.
- Mix eggs and milk to make egg wash in shallow bowl.
- Combine bread crumbs, Italian seasoning and parmesan in separate shallow pan.
- Dredge chicken breasts in flour mixture, then egg wash mixture, then coat breasts in bread crumb mixture.
- Place olive oil and butter in skillet over medium heat; place chicken breasts in skillet and brown on both sides.(3-4 minutes per side)
- Remove from skillet and place on baking sheet for 20 minutes to finish cooking in oven.
- Place ham and cheese on top of chicken breasts and return to oven 'til cheese is melted. (approximately 5 minutes).
Most Helpful
So easy and had a great flavor! Both my DSs ate this all! The only change I made was to use shredded cheese instead of sliced. Will use this breading recipe often, it has a great flavor. Made for ZWT8.
Delicious!!!! Only problem was I didn't make enough!!!!! Will make again.
Very good! We really enjoyed it. I will be making again. A quick and easy dinner. The breading is fabulous. Just a word of caution, because of the parmesan cheese in the breading, it has a tendency to brown quickly in the skillet. Watch your heat! I used very thick chicken breasts which required additional baking time. I didn't bother to pound them flat, call me lazy :^P /


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Workshop's life... by Yoann-LosselWatch
©2014-2016 Yoann-Lossel
Visit my Facebook artist page —> www.facebook.com/pages/Yoann-L…
Damn!!! now you are one hell-of-an artist...to be able to paint such artwork in a traditional way requires a lot of skill not many have...the patience, the detail, colour application..etc...most of us did wat you did digitally nowadays bcos its much easier to correct if theres some mistake...I bet if its easy for you traditionally, then you must b able to paint digitally without difficulty...awesome man keep at it.
Absolutely, the traditionnal way is so demanding. Sometimes it's too much...
But I can't do anything else, I'm in love with this process.
To be honnest, I never tried to paint digitally.
But I can't do anything else, I'm in love with this process.
To be honnest, I never tried to paint digitally.
yes of course, the one thing that is cool by doing it traditionally is the satisfaction when you get the results after a long and tiring process...the value of our work, time spent to see it finally realised...you should b proud bcoz u did it traditionally, an excruciating process no doubt for those without patience like me...hehe. Painting digitally is for those who can't wait to visualise their ideas immediately, which is fun bcos its rather fast, depending on our techniques and how we organise our work process...I'm still trying to figure that out myself tho...hehe
anyways, cool artworks. Cant wait to see more...
anyways, cool artworks. Cant wait to see more...
Dancing with the art craft! %)
I love an every detail in your workspace!
Keep inspiring yourself!
I love an every detail in your workspace!
Keep inspiring yourself!
stunning work- nice studio space
j'adore les touches d'or, les petailles et les animaux un peu metaphorique. mersi beacoup,
j'adore les touches d'or, les petailles et les animaux un peu metaphorique. mersi beacoup,
Legendary! Good stuff! ▲
This workshop is beautiful. Even a picture of it gives inspiration.
what do you listen?
hey that's you!
What a beautiful picture.
thats fantastic just fantastic
This feels really romantic for some reason. The lighting is perfect it really sets the mood. Makes the subject very sexy.
I have a table like that at my house. I also love how you wear headphones while working, I thought I was the only one who had something playing in the background. Maybe it's an artist thing. Maybe it's Maybelline.
Great atmosphere ^_^
Beautiful room
This is really cool, I'm working to have this kind of life.
are you picasso's son?! THAT ART IS SO COOL
A great creative environment! I see you are influenced by epic classics! That makes sense, I can really see it in your work. Isn't that The Lady of Shalott back there? I love it! Thanks for this view into your workshop.
looks pretty uncomfortable.
Looks like a great place to be!
Love it!
love the water house in the bg
Why do you have two adjacent "DALI" books?
That Cintiq is massive, what model is it?
Beautiful workshop~
amo tu estudiooooooooo
I'm sorry I can't allow this you are too good my mind will explode
I'd love to be there *-*


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Suggestions that have been given to us are: Meira, Ora, and Lior(a).
What is the difference between these words and their meaning of light? Are any of them super common or more modern names? How to choose? Thanks in advance for the help!
T (37) + D (35) m/c 11/09, m/c 1/10, m/c 6/13
Elodie Iris 12/26/10 ~ Phoebe June 4/10/14
Meira = she who illuminates
Ora= light
Lior/a = my light
You can also do "Orly/Orli" - which also means 'my light'
"Eliora" is also becoming popular.
"Lior" is probably the most modern Israeli one. All are pretty and nice.
my vote for "Leora" may be biased (it's my name!)
1-^b/g^ 22wk 2-mc 10wk 3- ^Micha^ (7.19-24.11) & ^Asaf^ (7.19-28.11) 24 wk 4- mc 5wk 5-^b^ 18 wk 6-bo 7wk 7-mc 6wk 8- Y 7.27.14
My sister's name is Meira, it means "one who gives light". Ora is simply "light" and Liora means "my light". I have heard all of these quite commonly among people who use Hebrew names.
Babies make everything more fun!
Our youngest is Michal Eliorah.Bluma. I didn't know Eliorah was becoming popular. The name was for a close friend who passed Eli and my great grandpa Orin.
Zu 4-03 Tev 7-04 Frei 5-06 Mo 6-09 Mimi 12-11
Does your child have tourette syndrome? Join us
DS1 arrived February 2013
DS2 arrived March 2015
T (37) + D (35) m/c 11/09, m/c 1/10, m/c 6/13
Elodie Iris 12/26/10 ~ Phoebe June 4/10/14
I like Orly and Ziv. There is an adorable girl who I've taught many times this year and everyone calls her Zivi. I love it!
Rock Star - Nov 2010 Spark - May 2014
Me 38, DH 38 Unicornuate Uterus but preg naturally....Rebecca born 23 April 2014. ....my life just became 3 dimensional
Diamond Boobies (oYo), EBF, CD, Babywearing, Co-sleeping, NUHB


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As D-Day approaches, Colonel Breed hands the roguish Major Reisman an important assignment: He must train a team of soldiers to parachute across enemy lines and assassinate German personnel at a French chateau. The soldiers, recruited from murderers, rapists and criminals on death row, are promised commuted sentences. In spite of their history, the 12 men prove a spirited and courageous unit. Led by Major Reisman, they will exact revenge.
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Are you C J Danpure?Claim your profile
Publications (126)761.56 Total impact
Article: Pyridoxamine and pyridoxal are more effective than pyridoxine in rescuing folding-defective variants of human alanine: Glyoxylate aminotransferase causing primary hyperoxaluria type I[Show abstract] [Hide abstract]
ABSTRACT: Vitamin B6 in the form of pyridoxine (PN) is one of the most widespread pharmacological therapies for inherited diseases involving pyridoxal phosphate (PLP)-dependent enzymes, including primary hyperoxaluria type I (PH1). PH1 is caused by a deficiency of liver-peroxisomal alanine:glyoxylate aminotransferase (AGT), which allows glyoxylate oxidation to oxalate leading to the deposition of insoluble calcium oxalate in the kidney. Only a minority of PH1 patients, mostly bearing the F152I and the G170R mutations, respond to PN, the only pharmacological treatment currently available. Moreover, excessive doses of PN reduce the specific activity of AGT in a cellular PH1-model. Nevertheless, the possible effect(s) of other B6 vitamers have not been investigated previously. Here we compared the ability of PN in rescuing the effects of the F152I and G170R mutations with that of pyridoxamine (PM) and pyridoxal (PL). We found that supplementation with PN raises the intracellular concentration of pyridoxine phosphate (PNP), which competes with PLP for apoenzyme binding leading to the formation of an inactive AGT-PNP complex. In contrast, PNP does not accumulate in the cell upon PM or PL supplementation, but higher levels of PLP and pyridoxamine phosphate (PMP), the two active forms of the AGT coenzyme, are found. This leads to an increased ability of PM and PL to rescue the effects of the F152I and G170R mutations compared to PN. A similar effect was also observed for other folding-defective AGT variants. Thus, PM and PL should be investigated as matter of importance as therapeutics for PH1-patients bearing folding mutations. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: firstname.lastname@example.com.
Article: Development of a Phenotypic High-Content Assay to Identify Pharmacoperone Drugs for the Treatment of Primary Hyperoxaluria Type 1 by High-Throughput Screening[Show abstract] [Hide abstract]
ABSTRACT: Primary hyperoxaluria is a severe disease for which the best current therapy is dialysis or organ transplantation. These are risky, inconvenient, and costly procedures. In some patients, pyridoxine treatment can delay the need for these surgical procedures. The underlying cause of particular forms of this disease is the misrouting of a specific enzyme, alanine:glyoxylate aminotransferase (AGT), to the mitochondria instead of the peroxisomes. Pharmacoperones are small molecules that can rescue misfolded proteins and redirect them to their correct location, thereby restoring their function and potentially curing disease. In the present study, we miniaturized a cell-based assay to identify pharmacoperone drugs present in large chemical libraries to selectively correct AGT misrouting. This assay employs AGT-170, a mutant form of AGT that predominantly resides in the mitochondria, which we monitor for its relocation to the peroxisomes through automated image acquisition and analysis. Over the course of a pilot screen of 1,280 test compounds, we achieved an average Z'-factor of 0.72±0.02, demonstrating the suitability of this assay for HTS.
- [Show abstract] [Hide abstract]
ABSTRACT: Primary hyperoxaluria 1 (PH1; Online Mendelian Inheritance in Man no. 259900), a typically lethal biochemical disorder, may be caused by the AGT(P11LG170R) allele in which the alanine:glyoxylate aminotransferase (AGT) enzyme is mistargeted from peroxisomes to mitochondria. AGT contains a C-terminal peroxisomal targeting sequence, but mutations generate an N-terminal mitochondrial targeting sequence that directs AGT from peroxisomes to mitochondria. Although AGT(P11LG170R) is functional, the enzyme must be in the peroxisome to detoxify glyoxylate by conversion to alanine; in disease, amassed glyoxylate in the peroxisome is transported to the cytosol and converted to oxalate by lactate dehydrogenase, leading to kidney failure. From a chemical genetic screen, we have identified small molecules that inhibit mitochondrial protein import. We tested whether one promising candidate, Food and Drug Administration (FDA)-approved dequalinium chloride (DECA), could restore proper peroxisomal trafficking of AGT(P11LG170R). Indeed, treatment with DECA inhibited AGT(P11LG170R) translocation into mitochondria and subsequently restored trafficking to peroxisomes. Previous studies have suggested that a mitochondrial uncoupler might work in a similar manner. Although the uncoupler carbonyl cyanide m-chlorophenyl hydrazone inhibited AGT(P11LG170R) import into mitochondria, AGT(P11LG170R) aggregated in the cytosol, and cells subsequently died. In a cellular model system that recapitulated oxalate accumulation, exposure to DECA reduced oxalate accumulation, similar to pyridoxine treatment that works in a small subset of PH1 patients. Moreover, treatment with both DECA and pyridoxine was additive in reducing oxalate levels. Thus, repurposing the FDA-approved DECA may be a pharmacologic strategy to treat PH1 patients with mutations in AGT because an additional 75 missense mutations in AGT may also result in mistrafficking.
- [Show abstract] [Hide abstract]
ABSTRACT: Primary hyperoxaluria type 1 (PH1) is a rare hereditary calcium oxalate kidney stone disease caused by a deficiency of the liver-specific pyridoxal-phosphate-dependent peroxisomal enzyme alanine:glyoxylate aminotransferase (AGT). About one third of patients are responsive to pharmacological doses of pyridoxine (vitamin B6), but its mechanism of action is unknown. Using stably transformed CHO cells expressing various normal and mutant forms of AGT, we have shown that pyridoxine increases the net expression, catalytic activity and peroxisomal import of the most common mistargeted mutant form of AGT (i.e. Gly170Arg on the background of the polymorphic minor allele). These multiple effects explain for the first time the action of pyridoxine in the most common group of responsive patients. Partial effects of pyridoxine were also observed for two other common AGT mutants on the minor allele (i.e. Phe152Ile and Ile244Thr) but not for the minor allele mutant AGT containing a Gly41Arg replacement. These findings demonstrate that pyridoxine, which is metabolised to pyridoxal phosphate, the essential cofactor of AGT, achieves its effects both as a prosthetic group (increasing enzyme catalytic activity) and a chemical chaperone (increasing peroxisome targeting and net expression). This new understanding should aid the development of pharmacological treatments that attempt to enhance efficacy of pyridoxine in PH1, as well as encouraging a re-evaluation of the extent of pyridoxine responsiveness in PH1, as more patients than previously thought might benefit from such treatment.
Article: Four of the Most Common Mutations in Primary Hyperoxaluria Type 1 Unmask the Cryptic Mitochondrial Targeting Sequence of Alanine:glyoxylate Aminotransferase Encoded by the Polymorphic Minor Allele[Show abstract] [Hide abstract]
ABSTRACT: The gene encoding the liver-specific peroxisomal enzyme alanine:glyoxylate aminotransferase (AGT, EC. 220.127.116.11) exists as two common polymorphic variants termed the major and minor alleles. The Pro11Leu amino acid replacement encoded by the minor allele creates a hidden N-terminal mitochondrial targeting sequence (MTS), the unmasking of which occurs in the hereditary calcium oxalate kidney stone disease primary hyperoxaluria type 1 (PH1). This unmasking is due to the additional presence of a common disease-specific Gly170Arg mutation which is encoded by about one third of PH1 alleles. The Pro11Leu and Gly170Arg replacements interact synergistically to reroute AGT to the mitochondria where it cannot fulfil its metabolic role (i.e. glyoxylate detoxification) effectively. In the present study we have re-investigated the consequences of the interaction between Pro11Leu and Gly170Arg in stably transformed CHO cells, and have studied for the first time whether a similar synergism exists between Pro11Leu and three other mutations that segregate with the minor allele (i.e. Ile244Thr, Phe152Ile and Gly41Arg). Our investigations show that the latter three mutants are all able to unmask the cryptic Pro11Leu-generated MTS and as a result, all are mistargeted to the mitochondria. However, whereas the Gly170Arg, Ile244Thr and Phe152Ile mutants are able to form dimers and are catalytically active, the Gly41Arg mutant aggregates and is inactive. These studies open up the possibility that all PH1 mutations, which segregate with the minor allele, might also lead to the peroxisome-to-mitochondrion mistargeting of AGT, a suggestion which has important implications for the development of treatment strategies for PH1.
Article: OxalEurope. Primary hyperoxaluria Type 1: indications for screening and guidance for diagnosis and treatment[Show abstract] [Hide abstract]
ABSTRACT: Primary hyperoxaluria Type 1 is a rare autosomal recessive inborn error of glyoxylate metabolism, caused by a deficiency of the liver-specific enzyme alanine:glyoxylate aminotransferase. The disorder results in overproduction and excessive urinary excretion of oxalate, causing recurrent urolithiasis and nephrocalcinosis. As glomerular filtration rate declines due to progressive renal involvement, oxalate accumulates leading to systemic oxalosis. The diagnosis is based on clinical and sonographic findings, urine oxalate assessment, enzymology and/or DNA analysis. Early initiation of conservative treatment (high fluid intake, pyridoxine, inhibitors of calcium oxalate crystallization) aims at maintaining renal function. In chronic kidney disease Stages 4 and 5, the best outcomes to date were achieved with combined liver-kidney transplantation.
Article: The N-terminal extension is essential for the formation of the active dimeric structure of liver peroxisomal alanine:glyoxylate aminotransferase[Show abstract] [Hide abstract]
ABSTRACT: Alanine:glyoxylate aminotransferase (AGT) is a pyridoxal-phosphate (PLP)-dependent enzyme. Its deficiency causes the hereditary kidney stone disease primary hyperoxaluria type 1. AGT is a highly stable compact dimer and the first 21 residues of each subunit form an extension which wraps over the surface of the neighboring subunit. Naturally occurring and artificial amino acid replacements in this extension create changes in the functional properties of AGT in mammalian cells, including relocation of the enzyme from peroxisomes to mitochondria. In order to elucidate the structural and functional role of this N-terminal extension, we have analyzed the consequences of its removal using a variety of biochemical and cell biological methods. When expressed in Escherichia coli, the N-terminal deleted form of AGT showed the presence of the protein but in an insoluble form resulting in only a 10% soluble yield as compared to the full-length version. The purified soluble fraction showed reduced affinity for PLP and greatly reduced catalytic activity. Although maintaining a dimer form, it was highly prone to self-aggregation. When expressed in a mammalian cell line, the truncated construct was normally targeted to peroxisomes, where it formed large stable but catalytically inactive aggregates. These results suggest that the N-terminal extension plays an essential role in allowing AGT to attain its correct conformation and functional activity. The precise mechanism of this effect is still under investigation.
- [Show abstract] [Hide abstract]
ABSTRACT: The primary hyperoxalurias are a group of rare hereditary calcium oxalate kidney stone diseases, the best characterized of which are primary hyperoxaluria type 1 (PH1) and type 2 (PH2). Deficiencies of alanine: glyoxylate aminotransferase (AGT) in PH1 and glyoxylate/hydroxypyruvate reductase (GR/HPR) in PH2 lead to the increased synthesis and excretion of the metabolic end product, oxalate. Insoluble calcium oxalate crystallizes out in the kidney and urinary tract, leading to kidney dysfunction and eventually complete organ failure. More than 100 mutations have been found in PH1, but less than 20 in PH2. The crystal structures of both AGT and GR/HPR have been solved, enabling rationalization of the untoward effects of at least some of the mutations, as well as how in PH1 some of the mutations interact synergistically with the common Pro11Leu polymorphism. A wide variety of enzyme phenotypes are found in PH1, but perhaps the most spectacular is the unparalleled peroxisome-to- mitochondrion AGT mistargeting caused by a combination of the Pro11Leu polymorphism and Gly170Arg mutation. Although remaining catalytically active in this location, mitochondrial AGT is metabolically ineffective. Classic stone treatments, such as hydration and crystallization inhibitors, are applicable to PH1 and PH2. However, some treatments such as pyridoxine therapy and liver transplantation (enzyme replacement therapy) are restricted to PH1.
Article: Structural implications of a G170R mutation of alanine:glyoxylate aminotransferase that is associated with peroxisome-to-mitochondrion mistargeting[Show abstract] [Hide abstract]
ABSTRACT: In a subset of patients with the hereditary kidney-stone disease primary hyperoxaluria type 1 (PH1), the liver-specific enzyme alanine:glyoxylate aminotransferase (AGT) is mistargeted from peroxisomes to mitochondria. This is a consequence of the combined presence of the common P11L polymorphism and a disease-specific G170R mutation. In this paper, the crystal structure of mutant human AGT containing the G170R replacement determined at a resolution of 2.6 A is reported. The crystal structure of AGT consists of an intimate dimer in which an extended N-terminal segment of 21 amino acids from one subunit wraps as an elongated irregular coil around the outside of the crystallographic symmetry-related subunit. In addition to the N-terminal segment, the monomer structure contains a large domain of 261 amino acids and a small C-terminal domain of 110 amino acids. Comparison of the mutant AGT structure and that of wild-type normal AGT shows that the two structures are almost identical, with a backbone-atom r.m.s. deviation of 0.34 A. However, evidence of significant local structural changes in the vicinity of the G170R mutation might be linked to the apparent decrease in protein stability.
Article: Oxalate and Primary Hyperoxaluria
Article: Proceedings of the 8th International Primary Hyperoxaluria Workshop, UCL-Institute of Child Health, 29–30 June 2007
Article: Primary hyperoxaluria type 1: AGT mistargeting highlights the fundamental differences between the peroxisomal and mitochondrial protein import pathways[Show abstract] [Hide abstract]
ABSTRACT: Primary hyperoxaluria type 1 (PH1) is an atypical peroxisomal disorder, as befits a deficiency of alanine:glyoxylate aminotransferase (AGT), which is itself an atypical peroxisomal enzyme. PH1 is characterized by excessive synthesis and excretion of the metabolic end-product oxalate and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract. Disease in many patients is caused by a unique protein trafficking defect in which AGT is mistargeted from peroxisomes to mitochondria, where it is metabolically ineffectual, despite remaining catalytically active. Although the peroxisomal import of human AGT is dependent upon the PTS1 import receptor PEX5p, its PTS1 is exquisitely specific for mammalian AGT, suggesting the presence of additional peroxisomal targeting information elsewhere in the AGT molecule. This and many other functional peculiarities of AGT are probably a consequence of its rather chequered evolutionary history, during which much of its time has been spent being a mitochondrial, rather than a peroxisomal, enzyme. Analysis of the molecular basis of AGT mistargeting in PH1 has thrown into sharp relief some of the fundamental differences between the requirements of the peroxisomal and mitochondrial protein import pathways, particularly the properties of peroxisomal and mitochondrial matrix targeting sequences and the different conformational limitations placed upon importable cargos.
Article: Reconstruction of human hepatocyte glyoxylate metabolic pathways in stably transformed Chinese-hamster ovary cells[Show abstract] [Hide abstract]
ABSTRACT: Failure to detoxify the intermediary metabolite glyoxylate in human hepatocytes underlies the metabolic pathology of two potentially lethal hereditary calcium oxalate kidney stone diseases, PH (primary hyperoxaluria) types 1 and 2. In order to define more clearly the roles of enzymes involved in the metabolism of glyoxylate, we have established singly, doubly and triply transformed CHO (Chinese-hamster ovary) cell lines, expressing all combinations of normal human AGT (alanine:glyoxylate aminotransferase; the enzyme deficient in PH1), GR/HPR (glyoxylate/hydroxypyruvate reductase; the enzyme deficient in PH2), and GO (glycolate oxidase). We have embarked on the preliminary metabolic analysis of these transformants by studying the indirect toxicity of glycolate as a simple measure of the net intracellular production of glyoxylate. Our results show that glycolate is toxic only to those cells expressing GO and that this toxicity is diminished when AGT and/or GR/HPR are expressed in addition to GO. This finding indicates that we have been able to reconstruct the glycolate-->glyoxylate, glyoxylate-->glycine, and glyoxylate-->glycolate metabolic pathways, catalysed by GO, AGT, and GR/HPR respectively, in cells that do not normally express them. These results are compatible with the findings in PH1 and PH2, in which AGT and GR/HPR deficiencies lead to increased oxalate synthesis, due to the failure to detoxify its immediate precursor glyoxylate. These CHO cell transformants have a potential use as a cell-based bioassay for screening small molecules that stabilize AGT or GR/HPR and might have use in the treatment of PH1 or PH2.
Article: Peroxisomal Import of Human Alanine:glyoxylate Aminotransferase Requires Ancillary Targeting Information Remote from Its C Terminus[Show abstract] [Hide abstract]
ABSTRACT: Although human alanine:glyoxylate aminotransferase (AGT) is imported into peroxisomes by a Pex5p-dependent pathway, the properties of its C-terminal tripeptide (KKL) are unlike those of any other type 1 peroxisomal targeting sequence (PTS1). We have previously suggested that AGT might possess ancillary targeting information that enables its unusual PTS1 to work. In this study, we have attempted to locate this information and to determine whether or not it is a characteristic of all vertebrate AGTs. Using the two-hybrid system, we show that human AGT interacts with human Pex5p in mammalian cells, but not yeast cells. Using (immuno)fluorescence microscopic analysis of the distribution of various constructs expressed in COS cells, we show the following. 1) The putative ancillary peroxisomal targeting information (PTS1A) in human AGT is located entirely within the smaller C-terminal structural domain of 110 amino acids, with the sequence between Val-324 and Ile-345 being the most likely candidate region. 2) The PTS1A is present in all mammalian AGTs studied (human, rat, guinea pig, rabbit, and cat), but not amphibian AGT (Xenopus). 3) The PTS1A is necessary for peroxisomal import of human, rabbit, and cat AGTs, but not rat and guinea pig AGTs. We speculate that the internal PTS1A of human AGT works in concert with the C-terminal PTS1 by interacting with Pex5p indirectly with the aid of a yet-to-be-identified mammal-specific adaptor molecule. This interaction might reshape the tetratricopeptide repeat domain allosterically, enabling it to accept KKL as a functional PTS1.
Article: Comparative analysis of the evolutionary relationship between diet and enzyme targeting in bats, marsupials and other mammals[Show abstract] [Hide abstract]
ABSTRACT: The subcellular distribution of the enzyme alanine:glyoxylate aminotransferase (AGT) in the livers of different mammals appears to be related to their natural diets. Thus, AGT tends to be mitochondrial in carnivores, peroxisomal in herbivores, and both mitochondrial and peroxisomal in omnivores. To what extent this relationship is an incidental consequence of phylogenetic structure or an evolutionarily meaningful adaptive response to changes in dietary selection pressure is unknown. In order to distinguish between these two possibilities, we have determined the subcellular distribution of AGT in the livers of 22 new mammalian species, including members of three orders not studied before. In addition, we have analysed the statistical relationship between AGT distribution and diet in all 77 mammalian species, from 12 different orders, for which the distribution is currently known. Our analysis shows that there is a highly significant correlation between AGT distribution and diet, independent of phylogeny. This finding is compatible with the suggestion that the variable intracellular targeting of AGT is an adaptive response to episodic changes in dietary selection pressure. To our knowledge, this is the first example of such a response being manifested at the molecular and cellular levels across the breadth of Mammalia.
- [Show abstract] [Hide abstract]
ABSTRACT: Primary hyperoxaluria type 1 (PH1) is a rare autosomal-recessive disorder caused by a deficiency of the liver-specific enzyme alanine:glyoxylate aminotransferase (AGT). AGT deficiency results in increased synthesis and excretion of the metabolic end-product oxalate and deposition of insoluble calcium oxalate in the kidney and urinary tract. Classic treatments for PH1 have tended to address the more distal aspects of the disease process (i.e. the symptoms rather than the causes). However, advances in the understanding of the molecular etiology of PH1 over the past decade have shifted attention towards the more proximal aspects of the disease process (i.e. the causes rather than the symptoms). The determination of the crystal structure of AGT has enabled the effects of some of the most important missense mutations in the AGXT gene to be rationalised in terms of AGT folding, dimerization and stability. This has opened up new possibilities for the design pharmacological agents that might counteract the destabilizing effects of these mutations and which might be of use for the treatment of a potentially life-threatening and difficult-to-treat disease.
Article: Diet and the frequency of the alanine : glyoxylate aminotransferase Pro11Leu polymorphism in different human populations[Show abstract] [Hide abstract]
ABSTRACT: The intermediary metabolic enzyme alanine:glyoxylate aminotransferase (AGT) contains a Pro11Leu polymorphism that decreases its catalytic activity by a factor of three and causes a small proportion to be mistargeted from its normal intracellular location in the peroxisomes to the mitochondria. These changes are predicted to have significant effects on the synthesis and excretion of the metabolic end-product oxalate and the deposition of insoluble calcium oxalate in the kidney and urinary tract. Based on the evolution of AGT targeting in mammals, we have previously hypothesised that this polymorphism would be advantageous for individuals who have a meat-rich diet, but disadvantageous for those who do not. If true, the frequency distribution of Pro11Leu in different extant human populations should have been shaped by their dietary history so that it should be more common in populations with predominantly meat-eating ancestral diets than it is in populations in which the ancestral diets were predominantly vegetarian. In the present study, we have determined frequency of Pro11Leu in 11 different human populations with divergent ancestral dietary lifestyles. We show that the Pro11Leu allelic frequency varies widely from 27.9% in the Saami, a population with a very meat-rich ancestral diet, to 2.3% in Chinese, who are likely to have had a more mixed ancestral diet. F ST analysis shows that the differences in Pro11Leu frequency between some populations (particularly Saami vs Chinese) was very high when compared with neutral loci, suggesting that its frequency might have been shaped by dietary selection pressure.
- [Show abstract] [Hide abstract]
ABSTRACT: Not all members of the order Carnivora are carnivorous. Some are omnivorous, and a few, such as the giant panda, Ailuropoda melanoleuca, are almost exclusively herbivorous. Although a number of adaptations to increased plant-eating are recognized within Carnivora, few have been studied at the molecular level. One molecular adaptation to diet that is spread widely across Mammalia is the differential intracellular targeting of the intermediary metabolic enzyme alanine:glyoxylate aminotransferase (AGT), which tends to be mitochondrial in carnivores, peroxisomal in herbivores, and both mitochondrial and peroxisomal in omnivores. In the present study, we have analyzed the targeting of AGT in Carnivora in relation to species' natural diets. We show not only that there has been an adaptive shift in AGT targeting from the mitochondrion toward the peroxisome as diets have shifted from being mainly carnivorous to ones that are more omnivorous and herbivorous but also that in one lineage, namely that of the giant panda, there is evidence for positive selection pressure at the molecular level on the AGT mitochondrial targeting sequence to decrease its efficiency, thereby allowing more AGT to be targeted to the peroxisomes.
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ABSTRACT: The primary hyperoxalurias type 1 (PH1) and type 2 (PH2) are autosomal recessive calcium oxalate kidney stone diseases caused by deficiencies of the metabolic enzymes alanine:glyoxylate aminotransferase (AGT) and glyoxylate/hydroxypyruvate reductase (GR/HPR), respectively. Over 50 mutations have been identified in the AGXT gene (encoding AGT) in PH1, associated with a wide variety of effects on AGT, including loss of catalytic activity, aggregation, accelerated degradation, and peroxisome-to-mitochondrion mistargeting. Some of these mutations segregate and interact synergistically with a common polymorphism. Over a dozen mutations have been found in the GRHPR gene (encoding GR/HPR) in PH2, all associated with complete loss of glyoxylate reductase enzyme activity and immunoreactive protein. The crystal structure of human AGT, but not human GR/HPR, has been solved, allowing the effects of many of the mutations in PH1 to be rationalised in structural terms. Detailed analysis of the molecular aetiology of PH1 and PH2 has led to significant improvements in all aspects of their clinical management. Enzyme replacement therapy by liver transplantation can provide a metabolic cure for PH1, but it has yet to be tried for PH2. New treatments that aim to counter the effects of specific mutations on the properties of the enzymes could be feasible in the not-too-distant future.
Top Journals
University College London
Londinium, England, United Kingdom
- • Department of Cell and Developmental Biology
- • MRC Laboratory for Molecular Cell Biology
Cardiff UniversityCardiff, Wales, United Kingdom
University Children's Hospital BaselBâle, Basel-City, Switzerland
University of AmsterdamAmsterdamo, North Holland, Netherlands
MRC Clinical Sciences CentreLondon Borough of Harrow, England, United Kingdom
University of ChicagoChicago, Illinois, United States
Florida Clinical Research CenterFlorida, United States
University of Cambridge
Cambridge, ENG, United Kingdom
- Department of Veterinary Medicine


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Inktober #16 Insurgent by Mecha-ZoneWatch
©2013-2016 Mecha-Zone
Original design this time. Had a lot of fun with it.
Very cool looking concept. Great style!
Oooooo cool
This is incredible....what did you use?
microns and a pilot brush pen. 30% gray marker for shading.
Cool design.
really cool
gonna grab some details out of this
gonna grab some details out of this
That's some Shoji Kawamori shit, right there.
Heck yeah, Kawamori San has been a huge inspiration and is still someone I look up to.
It kind of reminds me of the Chiram Ishkick from Super Dimensional Century Orguss. Sure, I'd have to chop off the two rail cannons to numbs and take off the wheels, but it does look like a Ishkick to me. Then again, I believe Shoji Kawamori worked on that series as well. I know that he didn't work on Sourthern Cross. Mind you, I still like your design.
Oh I like this one a lot. Has a modernised, more-deadly (wheeled) Invid feel to it. How long did it take to sketch this out?
This took me somewhere between 45 minutes and an hour. Hard to keep track because I sketched it while watching TV on the couch.
Invid was the first thing that came to mind when I saw this
Noice! I love it. Those big ol' wheel-feet!!!!
Oh yeah, who doesn't like wheel or tread feet? By the way, good luck with your Kickstarter. I posted about it last week to my Mecha Zone Facebook page. Hope it helps.
ohh i liek this oen quit a bit! I love the more organic shape to it. one of my favorites of yours.
I love this
OK this is PURTY. I've wanted to see what you do with original ideas. I'm happy with this result!
Thanks dude. I do original stuff all the time. If it isn't labeled as Battletech, then it's probably original. Even a lot of the Battletech stuff I post was designed by me... but there are a lot of style rules I have t follow for those so they have a certain look.
Looks like something Mr. Ohata would draw... ^_^
i have a feeling this thing would do epic hit and runs with lethal precision.
Very cool, Dave! Manned vehicle or drone?
Wow, this one looks like it'll haul ass on land!
Awesome design!


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Justice department to accuse FBI of invoking crises to obtain details of more than 2,000 calls, Washington Post reports
by Chris McGreal in Washington
19 January 2010
The US justice department is preparing a report which concludes that the FBI repeatedly broke the law by invoking terrorism emergencies that did not exist to obtain more than 2,000 telephone call records over four years from 2002, including those of journalists on US newspapers, according to emails obtained by the Washington Post.…
By Daniel Tencer
In a 2008 academic paper, President Barack Obama's appointee to head the Office of Information and Regulatory Affairs advocated "cognitive infiltration" of groups that advocate "conspiracy theories" like the ones surrounding 9/11.
Cass Sunstein, a Harvard law professor, co-wrote an academic article entitled "Conspiracy Theories: Causes and Cures," in which he argued that the government should stealthily infiltrate groups that pose alternative theories on historical events via "chat rooms, online social networks, or even real-space groups and attempt to undermine" those groups.…
By Glenn Greenwald
January 27, 2010
(updated below – Update II)
The Washington Post's Dana Priest today reports that "U.S. military teams and intelligence agencies are deeply involved in secret joint operations with Yemeni troops who in the past six weeks have killed scores of people." That's no surprise, of course, as Yemen is now another predominantly Muslim country (along with Somalia and Pakistan) in which our military is secretly involved to some unknown degree in combat operations without any declaration of war, without any public debate, and arguably (though not clearly) without any Congressional authorization.…
A talk delivered to the New England Antiwar Conference, MIT, January 30, 2010.
by Peter Dale Scott
Hello everyone! I'm honored to be invited to this important anti-war conference. As I am in the final stages of editing my next book, The Road to Afghanistan , I have been turning down invitations to speak. But I was eager to accept this one, and to join my friends and others in debunking the war on terror, the false justification for the Afghan-Pakistan war.…
February 9, 2010
A reader asked whether the U.S. is still in an official state of emergency, and if so, what that means.
The answer is yes, we are still in a state of emergency.
On September 11, 2001, the government declared a state of emergency. That declared state of emergency was formally put in writing on 9/14/2001:
"A national emergency exists by reason of the terrorist attacks at the World Trade Center, New York, New York, and the Pentagon, and the continuing and immediate threat of further attacks on the United States.
by Philip Giraldi
April 1, 2010 edition of American Conservative
Even in World War II, the United States did not attempt to assassinate U.S. citizens who went over to the enemy, but that has now changed with President Obama's overseas contingency operations. On Feb. 3, Director of National Intelligence Dennis Blair told the House Intelligence Committee that the United States government has developed procedures for killing American citizens abroad who are "involved" with groups threatening to carry out terrorist acts directed against other Americans.…
March 31, 2010
From the Huffington Post:
In anticipation of a final announcement as to the trial venue for the 9/11 plotters, September 11th Families for Peaceful Tomorrows is warning the president against "buckling to political pressure," calling the use of military tribunals the "wrong thing to do."
In a nearly four-minute long video, Donna Marsh O'Connor — a Peaceful Tomorrows member who lost her pregnant daughter when the Twin Towers collapsed — speaks both to the broad notion that America has a "historic commitment to justice" and, more narrowly, to the horse-trading politics that now surround terrorist trials.…
June 9, 2010 Update
from Cindy Sheehan
On the 7th anniversary of the illegal and immoral invasion of Iraq, eight people were arrested in front of the White House protesting the continuing crimes-you know that place! It's a big White House-as a matter of fact it's a HUGE White House in the middle of a park-like estate where heavily armed thugs protecting war criminals roam. It's okay to stop and gawk and take pictures if you are decked out in Hawaiian shirts or sundresses, but exercising fundamental rights to free speech or to peaceable assemble is not.…Continue reading
by Philip Shenon
June 10, 2010
The Daily Beast – Blogs & Stories
Anxious that Wikileaks may be on the verge of publishing a batch of secret State Department cables, investigators are desperately searching for founder Julian Assange. Philip Shenon reports. Plus, Daniel Ellsberg tells The Daily Beast: "Assange is in Some Danger."
(This story has been updated to reflect new developments on Assange's whereabouts, including the cancelation of a scheduled appearance in Las Vegas.)
Pentagon investigators are trying to determine the whereabouts of the Australian-born founder of the secretive website Wikileaks for fear that he may be about to publish a huge cache of classified State Department cables that, if made public, could do serious damage to national security, government officials tell The Daily Beast.…
June 10, 2010
By Michael Doyle
McClatchy Newspapers
WASHINGTON — A federal judge has forcefully put Yemeni citizen Mohammed Mohammed Hassan Odaini on the path to freedom after eight years of incarceration at Guantánamo Bay, Cuba.
In a 36-page opinion formally released Thursday, U.S. District Judge Henry H. Kennedy Jr. called Odaini's continued detention "unlawful" and said he'd "emphatically" grant Odaini's petition for a writ of habeas corpus.
The ruling issued secretly last month but published Thursday sets the 26-year-old Odaini up for potential release, though when and where he'll go remains unclear.…
By Jon Gold
They tried and tried to put the glove on, but it just didn't fit. I kid, I kid.
On March 20th 2010, I was arrested for crossing a police line. Today, I was acquitted for the crime, along with Cindy Sheehan, and Jim Veeder. Sadly, Matthis Chiroux, Elaine Brower, and Lafloria Walsh were found guilty of failing to obey.
This was my first arrest and trial so all of this was new to me.…
by Elaine Brower
The government had alleged that Lynne had facilitated communication between a man she was defending in court, fundamentalist Islamic cleric Omar Abdel Rahman, and people in Egypt. The judge in Lynne's trial sentenced her to 28 months in prison. An appeal to the conviction and sentencing resulted in a different judge upholding the conviction, while ordering a re-sentencing that was not "trivial", since Lynne had "indicated a lack of remorse". After her sentencing, her prosecutor praised the work of the FBI's New York Joint Terrorism Task Force for its role in the persecution of Lynne Stewart, and thanked U.S.…
By William Fisher
NEW YORK, Sep 27, 2010 (IPS) – Hundreds of people who believe they were falsely detained and imprisoned by the Department of Justice in the wake of the Sep. 11, 2001 attacks are now seeking redress through the U.S. courts.
The exact number of detainees is unclear, as no lists were ever released publicly. But according to a report by the Office of the Inspector General in 2002, 475 9/11 detainees were arrested and detained in New York and New Jersey.…
TSA and America's Zero Risk Culture
November 16, 2010
By Richard Forno
The lede on the DRUDGEREPORT most of Monday showed a Catholic nun being patted down at an airport security checkpoint, with the caption starkly declaring that
He's right.
Ten years after 9/11, Americans who fly are facing a Faustian choice between subjecting themselves to a virtual (and potentially medically damaging) strip search conducted in questionable machines run by federal employees or a psychologically damaging pat-down of their bodies.…
Interview by Cosmos Civil Disobedience at the White House for 9/11 Justice9/11 Truth News
9/11 Justice activist and researcher Jon Gold has announced his intention to chain himself to the White House fence this coming Monday, January 31. 9/11 Truth News asked Gold a few questions to find out more about the upcoming action.
9/11 Truth News: Why are you going to chain yourself to the White House?
Jon Gold: To try and bring attention to the fact that we were lied to about 9/11 and that there needs to be justice and accountability for what happened.…
By Robert Parry
February 17, 2011
Sometimes the hypocrisy is just overwhelming. So, it probably shouldn't surprise us that Secretary of State Hillary Clinton would deliver a speech hailing the peaceful protests that changed Egypt while 71-year-old Ray McGovern was roughed up and dragged away for standing quietly in protest of her support for the wars in Iraq and Afghanistan.
"So this is America," said McGovern as he was hustled from the room by two security guards.…
By Glenn Greenwald
February 18, 2011
In March, 2002, American citizen Jose Padilla was arrested in Chicago and publicly accused by then-Attorney-General John Ashcroft of being "The Dirty Bomber." Shortly thereafter, he was transferred to a military brig in South Carolina, where he was held for almost two years completely incommunicado (charged with no crime and denied all access to the outside world, including even a lawyer) and was brutally tortured, both physically and psychologically.…
March 7, 2011
by Ralph Lopez
War Is A Crime.org
As Obama's crime of the destruction of Bradley Manning continues to unfold before our very eyes, Manning friend David House now tells us that over 8 months in isolation with movement and sleep restrictions placed on him have been having their intended effect. House has told MSNBC that by the end of January Manning appeared "catatonic" and that he had "severe problems communicating," with it having taken House nearly 45 minutes on a recent visit to engage in any meaningful way (video below.) House said Manning's demeanor was as "if he had just woken up and didn't know what was going on around him." Manning was "utterly exhausted physically and mentally…it was difficult to have any kind of social engagement."
Also, a full month after Congressman Dennis Kucinich formally requested a visit, the Army has stalled on the request.…Continue reading


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|This document may not represent best practices for current development, links to downloads and other resources may no longer be valid. Current recommended version can be found here. ArchiveDisclaimer
Using a Windows Form User Control in MFC
Using the MFC Windows Forms support classes, you can host Windows Forms controls within your MFC applications as an ActiveX control within MFC dialog boxes or views. In addition, Windows Forms forms can be hosted as MFC dialog boxes.
The following sections describe how to:
Host a Windows Forms control in an MFC dialog box.
Host a Windows Forms user control as an MFC view.
Host a Windows Forms form as an MFC dialog box.
MFC Windows Forms integration works only in projects that link dynamically with MFC (projects in which AFXDLL is defined).
When you build your application using a private (modified) copy of the MFC Windows Forms interfaces DLL (mfcmifc80.dll), it will fail to install in the GAC unless you replace the Microsoft key with your own vendor key. For more information on assembly signing, see Programming with Assemblies and Strong Name Assemblies (Assembly Signing).
For sample applications using Windows Forms, see BirthdayPicker Sample: Demonstrates .NET Framework Resources with Windows Forms, Calculator Sample: Windows Forms Pocket Calculator, and Scribble Sample: MDI Drawing Application.
For a sample application that shows Windows Forms used with MFC, see MFC and WinForms Int e gration.
In This Section
Hosting a Windows Form User Control in an MFC Dialog Box
Hosting a Windows Form User Control as an MFC View


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See definition in Oxford Advanced Learner's DictionarySyllabification: di·rec·tor gen·er·al
Definition of director general in English:
noun(also director-general) (plural directors general) chiefly British
The chief executive of a large organization.
Example sentences
- Iraqi directors general head the local government offices overseeing basic services and have been drawn into planning local reconstruction.
- The chairman of Lloyds and the director general of the CBI agree.
- It does this every few years by appointing a chairman, who in turn chooses a director general.
Definition of director general in:
- British & World English dictionary
What do you find interesting about this word or phrase?
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Synonyms of grub in English:
2 informal we'll grab some grub on the way See food (sense 1)
verbBack to top
2 he began grubbing around in the trash
rummage, search, hunt, delve, dig, scrabble, ferret, root, rifle, fish, poke
Definition of grub in:
- British & World English dictionary
- US English dictionary
- English synonyms
What do you find interesting about this word or phrase?
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Armen lives with his family in the village Ddmashen in the Gegharkunik area. His family is not very big: his wife and two school-aged children. His wife has a specialty in nursing, but she doesn't work now and she greatly helps Armen around their farm.
Armen asks for a loan of 620,000 Armenian drams to enlarge the number of his farm animals; he wants to buy two cows, chickens and sheep.
Additional Information
About "Nor Horizon"
"Nor Horizon" UCO LLC is committed to promoting poverty alleviation in Armenia by providing high-quality financial and other business development services to enterprising individuals in under-served rural and urban markets who have a strong will to establish and develop their own small-scale businesses. Originally created as the Armenian micro credit program of Oxfam (Great Britain) in late 1995, "Nor Horizon" LLC has been licensed under supervision of the Central Bank of Armenia since early 2006.
For more information about "Nor Horizon," please visit the partner page or website.
To stay updated on loans from Armenia, please join the Armenia lending team at http://www.kiva.org/team/armenia.
Loan tags help lenders find loans that match certain areas of interest. You can add up to 5 tags for this loan.
About Armenia
149View loans »
Success!! The loan was 100% repaid
- Repayment Term
- 26 months (Additional Information)
- Repayment Schedule
- Monthly
- Pre-Disbursed:
- May 20, 2013
- Listed
- Jun 23, 2013
- Currency Exchange Loss:
- Possible
- Ended:
- Jun 17, 2015


text: Colton Pearson, 14, of Oklahoma City, was the first runner to cross the finish line Saturday, completing the run in just under 19 minutes. The Renaissance Run, a 5k run and walk, began at 8:30 a.m. at the Midwest City Community Center. Following the race, runners were invited to enjoy a pancake breakfast at Midwest Regional Medical Center. Photo by Jim Beckel, The Oklahoman. Jim Beckel


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Great piccies as usual. I love this thread.
You could try them in hanging baskets. They need to be somewhere the pollinating insects can get to them too. They may have got a bit hot and scorched the leaves.
They look pretty healthy plants.
Yes I think you are right. I now have around 10 different clematis, some of which only went in last autumn so can't wait to see what they all look like. I have a lovely double headed lilac/purple one with lots of buds on it. Will take a picture of it when it comes into flower.
Just catching up, some lovely photos of everyone's gardens. Here's a couple of mine this week.
Wigeila I beleive
Lots of aquilegia in flower, spirea in the background
Clematis, not sure which one though?
Looking forward to this beautiful clematis, did not flower last year at all.
Potato vine.
Not as impressive as some, but work in progress all the same.
Beautiful pictures. Will have to try and get there some day.
I work as a Senior Secretary at the moment. Prior to that I worked in Social Care, but left due to the very stressful nature of the business. But I have to say I am not keen on the current job and would love to retrain, but I just don't know what at. After taking up our allotment a few years ago, I wish I had more time to garden!!!
Our lives take such a twist and turn, and what once seemed fulfilling is now something I dread each morning. Especially as the kids get older and more independent.
Thanks OL. Lets hope they are ok?..
Great pictures everyone. I will have to get out tomorrow and take a few. Tulips and iris in the front garden looking lovely. Doronicum lovely spring colour. Been reshaping the borders so hopefully will get some good piccies once planting is in,
Hope you are not on the waiting list too long. I know the list is fairly short here. When we got our 3 years ago they had just set out 16 new allotments on a spare field behind the existing allotments. Rumour has it they were allotments around 50 years ago and then they went out of favour. Its great that home grown seems to be back in fashion now,
I'm particularly looking forward to making jam this year and perhaps trying chutneys. there's huge satisfaction from eating your own home grown produce. My parents have even set up a small raised bed and grown their own too.


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Fan Fic Recs: Cars
Proof that the remaining 10% is worth driving for here: These are recommendations made by Tropers for Fan Fics, all of which have been signed. After a few samples, you will be able to judge whether you might be interested in the 'fic, based on who recommended it. ''No-name recommendations will be denied. Nobody would back up the rec. Discussion of the recommendation is welcome on the discussion page. As such discussion is important, do remember to add the discussion page to the watchlist, if need be. Do warn when a fanfic may head into non-canon territory. Some people just don't like it, and as we all know, Shipping is Serious Business.
Authors, and WebsitesKnitzAndPearls
- Author: KnitzandPearls, on fanfiction.net
- Recommended by: Phoenix Martinez, Pixargirl
- Status: varying, depending on which one of the stories you thinking of.
- Synopsis: varying, depending on which one of the stories you thinking of.
- Most of the time it's Lightning and Sally stories. There's a couple non-romance stories.
- Pairing(s): Mostly canon, but has some like Doc/OC. Ect.
- Recommend by: Pixargirl
- Status: Most of the fanfictions she has written are finished. Only two are not as of 2014.
- Synopsis: Very well written. Focusing more on Lightning and Sally romance stores and various character driven one-shots.
- Pairing(s): Canon.
General FicsForgotten Highways by P.A.W.07
- Recommended by N8han11
- Synopsis: Chick, forced to play the underdog this season, finds his plagued past returning. Soon, everything is falling apart and everyone seems to want their pound of steel. So when McQueen challenges him to race, wanting to keep his pride, he accepts. Problem is Chick is still trying to figure out if the race was in his favor or not.
- Comments: One of the best Cars Fan Fics ever. The plot always flows well, and it actually makes Chick Hicks sympathetic.


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Bad Example – ATX
Bad Example is The New Movement's premiere sketch comedy show. They perform a brand new hour of sketch comedy every single Saturday, a feat that very few people in the country have ever attempted and much less done successfully.
Cast: Jeff Whitaker, Vanessa Gonzalez, Micheal Foulk, Roxy Castillo, Cody Cartagena, Stephanie Pace, Kelsey Rodgers and John Buseman.
Performance Info:
Austin Translation, Bad Example
Saturday, May 23rd, 7pm at Spider House Ballroom. TICKETS


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Sawmill Creek is located 20 yards off the Four O'clock ski run. This ski-in/shuttle-out property has a few different options for you when you want to hit the hill. Take a bus to the gondola, or over to Peak 9, and you are ready to start your day. Just one block from downtown Main Street, this Breckenridge condo is your key to a relaxing vacation. This condo has been recently remodeled and supplied with a new kitchen, contemporary furnishings and a new flat screen television in the living room. Relax by the stone gas fireplace after a day on the mountain, or enjoy the complexes' two indoor hot tubs. Sawmill Creek also provides shared grills for your use to cook up any of your favorite barbeque dishes.
Master Bedroom: Two Queens
Second Bedroom: King
Living Area: Queen Sleeper
*No Pets, No Smoking and No Air Conditioning
2 Bedrooms2 Baths# of Levels: One Level FloorplanBedding 1: 2 Queen BedsBedding 2: King BedCondoDeck: Private BalconyDishwasher: One DishwasherElevator: Elevator AccessFireplace: Gas FireplaceFloor in Building: First Floor UnitFour O'clockGrill/BBQ: On-Site GrillHot Tub Access: Indoor On-SiteHot Tub: Access to Hot Tubs
Internet: Free WirelessLaundry: Private Washer/DryerLiving Room Bedding: Queen Sleeper SofaLiving Room TV: Flat Screen TVMaster Bedroom TV: Tube TV in Master BdParking: Covered ParkingRating: Gold - A Rated UnitsSki Hill - Park AveSkiing: Ski-in / Shuttle-outSleeps: 8Town Access: 1 BlockView from Deck: Parking Lot Viewnon smoking only: Yespets not allowed: Yes
Thank you for entering your review. The review will become available to the system shortly.
Your request has been sent. We look forward to meeting all your vacation needs!


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Didn't really see that W coming from the 'Boys last night.
Printable View
Didn't really see that W coming from the 'Boys last night.
That halfback is kind of a beast too. Hadn't heard his name until last night...
Hey guys! Not forget your picks gotta be in TODAY! Packers/Bears play tonight. Good luck everybody, you'll need it! Lol
Correct me if I'm wrong but I think you get up to 10 mins before each game... Due to injuries and whatnot... So the GB/CHI needs to be in soon but doesn't everything else get 3 more days?
The ones I've done, once you submit your picks they can't be changed. So if you only pick one game the others can't be picked. I'm not positive about yahoo but I'm not risking it.
I just tried and you can change after you save but I get what you're sayin bruh.
As long as my Packers win I don't care about any pool!!
We don't need him... If he's going to sit out important games because his vag hurts and his contract is about to expire then let him sit. We have 4 other ace recievers that would love to take his #1 spot.
Last place? Damn it. Luckily it's only 3 games behind first.
We'll see where everyone is in a few weeks. First place now means nothing.
Can't wait to see the media explode when Sanchez sucks it up against the Steelers tomorrow...
Is it just me or do these replacement refs call an awful lot of pass interference? I don't ever remember seeing it called this much before.
These refs are terrible. And how about all the fuggin upsets today? Definitely pretty some shitty pick results after this week. Dallas got fuckstomped by Seattle... CAR over NO... ARI over NE... IND over MIN... PHI over BAL... STL is putting up a good fight for WASH as well.
Yeah we all got wrecked this week
It's not lookin too good for me. These teams are making me look retarded.
I'm just gonna start picking by who has the cuter quarterback. I'll probably get more wins.
You missed Monday night's pick for one you tool. But everyone did pretty shitty in our league this week. Tons of upsets.
No shit! NE, NO, Dallas, Wash... WTF?! Lol. That damn missed field goal by NE really fucked me! In my other FFB league I have him for my kicker. So it cost me 5 points, one wrong pick and knocked me out of the survivor pool (where you pick one team to win each week but can only pick a team once in the season. It's double elimination but I picked NO last week and NE this week!). This was my worse week picking EVER! I've never gone less than 10 correct in all the years doing pickems! But at least everybody got screwed this week so I'm still tied for first!


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Chibi Deadpool by forestwind48Watch
©2012-2016 forestwind48
Deadpool: Hewlp...I've fallen an' I'm too cute to get up...
Oh My gosh this is the cutest thing i have ever seen qwq
He's so cute I can't stand it!!
He's so adorable!! I just want to hold his lil' hand!!!
It's great! Love the messy coloring.
My regards to the artist.
D'awww.... He's like a puppy!!
So cute and adorable~ x3
Um, yeah, you could tell them you got the general pose from the shimeji community, specifically in this case, from my Deadpool Shimeji.
Even the little sign bubble and everything. C'mon
I appreciate you've kinda sourced it now, tho shimeji is better than chibi.
But that's all I really wanted, so thank you.
But that's all I really wanted, so thank you.
I'm sorry I forgot to do were I refrenced it from. If you want me to take it down then I will.
*fan girl scream*soo cute!!!!!
waw a wild chibi deadpool trow a pokebal on him !!! gotta catch him now
i really like your chibi deadpool he's so cute ^^
i really like your chibi deadpool he's so cute ^^
isnt widdle wade already a thing though
Widdle 'Wade!
Isnt it traced off of the Deadpool shimeji?
X3 Naaaw. So cute!


text:
From delicious dips to exotic entrees and desserts, The Everything Peruvian Cookbook is the perfect introduction to the latest culinary trend that is sweeping the food world. Peruvian cuisine is popping up in cities all over, and now popular food bloggers Morena Cuadra and Morena Escardo will teach you how to make these exciting dishes right at home!
You'll find recipes for 300 vibrant, flavorful dishes, including:
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