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Did you know that this planet has the resources and space for 250 Billion people to live in luxury and free from hunger?
Much better that a few of us just keep it all to ourselves....
What do you think of forced birth control for habitual welfare recipients?
Assassin~ Badass Buzz Guru 2012/06/11 13:10:19
Top Opinion
JMCC 2012/06/11 13:18:33No WAY
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- JusticeforJesus 2014/05/20 00:42:49
- Brosia - KarmaRaven 2012/07/02 17:31:12No WAYUmm... Pretty sure it is illegal to forcibly sterilizing someone. And, what would be considered "habitually" on welfare? Just because you are on welfare does not mean that you have a large family. I am on welfare and have 2 kids. And we have been on welfare for 10 years, is that habitual? As someone who has gotten a tubal ligation, is that enough for you? Or would you require that I also take a pill that taxpayers would have to pay for because it is too expensive for me.
- *~Amelie~* 2012/06/13 21:01:50No WAYi don't even see how this is a question! the idea is just ridiculous
- David Hussey 2012/06/13 04:05:12No WAYI think it reeks of nazi-esque thinking. A cleverly disguised return of a eugenics agenda.
- James 2012/06/13 04:03:40We should do this.We spay and neuter stray animals as a way to reduce the populations. If they can't get their act together, maybe this might not be such a bad idea.
- beach bum 2012/06/12 04:07:47
- the judgebigdogeagle-~PWCM~JLA 2012/06/11 23:32:09 (edited)Hmmmmm Maybe.....The minute you apply for welfare of any sort{Food Stamps} or such. You cannot reapply if you come in with one more kid.
- Lady Whitewolf 2012/06/11 22:38:08
- Nestofasssps 2012/06/11 21:54:39
- D D Nestofa... 2012/06/12 02:10:57What about the government telling us what we can and cannot ingest, eat?
- Nestofa... D D 2012/06/14 01:08:32why not stick to the topic,
- D D Nestofa... 2012/06/14 05:09:09We were talking birth control pills, that is forcing you to ingest a drug.
- ladyhma Nestofa... 2014/07/08 05:38:36+3I wish it was home of the free for myself...unfortunetly I'm a single female "paying" her way...land of the free utilities, food, rent, cell phone & most importantly healthcare...that is free if you are on welfare. Even with health insurance that I pay for if I'm hurt or ill I must choose to tough it out or miss work which means loss of income & potentially loss of my healthcare coverage. ( I'm a union construction worker benefits are earned by hours worked) having family & friends that are healthcare providers tell me how the patients on Medicaid flood the dr's office or the ER with the slightest complaint ( I would have to be half dead to go to the ER let alone run in with the common cold) and why & how can welfare recipients hmmm let's see no fear of bills for deductibles co-pays picking up the 20% of the bill private insurance doesn't cover. And like I mentioned I'm not some rich spoiled entitled girl...my job pays the bills I had to work hard & compete to have it. It's physically demanding. Yeah I'd love to not have to crawl home sore & tired everyday not worry where the rent was coming from I guess I should just exercise my freedom to get pregnant repeatedly then I wouldn't have to work so hard
- Ed 2012/06/11 20:52:08 (edited)
- boneman1 2012/06/11 19:41:48Hmmmmm Maybe.....+3I don't know about forced birth control, but there should be a limit to the amount and length of government assistance. I don't think you can force birth control, but I do think we should look at removing kids from homes where they're not being taken care of properly. If you're on government assistance and you keep having kids it might be best for the kids if they were put in a home that could provide for them.
- Katfish 2012/06/11 19:12:53
- sbtbill 2012/06/11 19:06:07
- The Duke 2012/06/11 19:00:10Hmmmmm Maybe.....Sounds like an excellent Socialist/Communist/Eugenics solution. To practice such? Totally unacceptable.
- firelooker 2012/06/11 18:55:36
- wutever 2012/06/11 18:51:22Hmmmmm Maybe.....
- +1I've heard too many times the poor tale of can't take birth control...hmm many options non hormonal IUD...condoms (supposed those same women that the pill "messes" with also have latex allergies...) or if it is a religious concern practice the rhythm method...hmm being catholic that is what is taught before marriage...but most religions that are against birth control also are against pre martial sex...just saying
- Diverbelo 2012/06/11 18:37:05
- j moraman 2012/06/11 18:36:51 (edited)We should do this.+4Yes and make it hard for these anchor baby dropping fools to stop popping out so many kids because they know Americans will take care of them. And before a crybaby lib yells out racist, there is nothing racist about the problem we are in, people that abuse the system and hard working americans pay while someone sits on there ass. Then we get the law breaking illegals here to have baby after baby, and again the goal oriented have to pay.
- Your right about that. I bet if there werent so many illegal aliens, the unemployment rate would probably be lower, even there are so many people that dont want to work, or think they are too good to do whats out ther
- RogerCoppock 2012/06/11 18:33:01
- j moraman RogerCo... 2012/06/11 18:45:24
- firelooker RogerCo... 2012/06/11 18:57:27
- boneman1 RogerCo... 2012/06/11 19:45:26
- Lady Wh... RogerCo... 2012/06/11 22:39:11TRIPLE LOLZ!!!
- D D Lady Wh... 2012/06/12 02:45:50You are all scared of birth control being taken away from women. It could go to where it is required.
- John Galt jr or Ron/jon 2012/06/11 17:37:08
- Tennyson James 2012/06/11 17:09:35
- JCD aka "biz" 2012/06/11 16:54:11No WAY+2Here in Europe, politicians are whining because women do not have enough children to pay for old people's pensions in the future. We in France have the highest fertility rate, partly because we encourage women to have babies, family allowances, free child care, paid maternity leave etc.
I understand that in America, you don't need children, pensions will be be paid anyway. Romney probably has a plan.
- Gloria JCD aka... 2012/06/12 12:51:53
- JCD aka... Gloria 2012/06/12 14:01:05
- frank 2012/06/11 16:41:01
- TerryAgee 2012/06/11 16:39:54
- JCD aka... TerryAgee 2012/06/11 16:57:26
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HP MediaSmart DVD won't play Blu-Ray's
When I pop a Blu-Ray in the optical, HP MediaSmart starts up and it looks like it's going to the play the movie however, it proceeds to ask me if I want to "activate" the app. I click YES thinking it's the first time I've used it so I guess I need to activate it.....however, it then pulls up a browser that directs me to download a patch from CyberLink.
I download and attempt to install the patch however it tells me that MediaSmart is currently installed and the patch requests to uninstall the previous version.
I agree to do so and after a few seconds, it comes up with an error message (error!! the product definition file lost).
I retry MediaSmart thinking this time I'll press NO, I don't want to activate and when I do this, nothing happens at all.
When I open My Computer, I can see the Transformers Blu-Ray in the drive and can right click and Explore the Blu-Ray as well so I know the drive is seeing it.
I called HP support and while the guy was nice enough, he was at a complete loss in trying to figure out why my Blu-Ray player would not play any movies. He tried multiple steps from going to the MSCONFIG and disabling all programs at Start Up, disabling Windows Installer (not sure why he wanted to try this step), to trying to recover the program from the partition itself. Nothing worked.
His final resolution was to perform a complete system recovery which I balked at as I have multiple programs installed (that would have to be reinstalled) and don't feel it necessary to perform a system recovery to "fix" my Blu-Ray issue.
And just to clarify, yes...my optical drive is indeed Blu-Ray optical drive.
Any advise or direction anyone can point me in would be greatly appreciated.
Thanks for your time.
Re: HP MediaSmart DVD won't play Blu-Ray's
try this , run HP Health Check and see if it finds an update to mediasmat , if not try this , open Mediasmart DVD at the bottom of mediasmart look for this * { Settings} and select update , media smart should find an update. my second question what BlueRay DVD are u trying to play , the latest version of media smart i have is version 220.127.116.1105 from my HDX driver and download page , tonight after reading your post the * {settings} i see a newer update for mediasmart DVD. i have not found a Blue Ray disk i cannot play , i buy the latest BD movies every tuesday when realesed
Re: HP MediaSmart DVD won't play Blu-Ray's
Re: HP MediaSmart DVD won't play Blu-Ray's
Thanks for the help as it is appreciated. Unfortunately, both steps that you presented did not fix the issue.
When I hit the update from from MediaSmart it does start the download and install however, I get the same message as I did before:
It tells me that MediaSmart is currently installed and the updaterequests to uninstall the previous version.
I agree to do so and after a few seconds, it comes up with the same error message (error!! the product definition file lost).
I tried Health Check as well, no joy.
I'm trying to play Transformers (yes, the 1st one) on the Blu-Ray....even tried 300 and still no joy.
Here's the kicker.....while waiting for a reply from my post, I went to CNET and downloaded CyberLink Power DVD 9 and the movie plays on this program but it won't on MediaSmart! What the heck?!
I'd like to say "problem solved" using a different player however, Power DVD 9 is not a free program as it costs nearly $100.00! I'm using the trial version now to see if this would correct my issue.
I don't feel I should have to kick down $100 for something I already have on my HDX18....
Frustrating to say the least.
Thanks for your input, it is appreciated.
Re: HP MediaSmart DVD won't play Blu-Ray's[ Edited ]
07-03-2009 09:48 PM - edited 07-03-2009 10:51 PM
ok try to restore the mediasmart soft ware heres how , http://h10025.www1.hp.com/ewfrf/wc/document?docnam
when u tried to update the software did u chose RUN , instead of downloading to HD? and did u close the mediasmart program during install
Re: HP MediaSmart DVD won't play Blu-Ray's
Re: HP MediaSmart DVD won't play Blu-Ray's
We have detected that the following Blu-ray Disc software player from CyberLink is installed in your system.
Please click on the "Download free patch now" button and press "Run" to install the patch. This will update your software player to the latest version.
Your Product:
Warning: Please note that if you decline to update your software, you may not be able to watch Blu-ray Disc movie titles.
Re: HP MediaSmart DVD won't play Blu-Ray's
Re: HP MediaSmart DVD won't play Blu-Ray's
Downloading the cyberlink patch didn't work. Finally had to reinstall the OS to get the blue ray working which shouldn't have had to been done in the first place
Re: HP MediaSmart DVD won't play Blu-Ray's
The first link leds to a cyberlink page where i can't continue because theres nothing to click on.
mediasmart is up to date with me, but the cyberlink BR advsor means my laptop doesn't habe a BR Player neither a software.
i'm using Win7_64. Any suggests?


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July 02, 2012
A good product. Still learning how to get full advantage of its functions.
June 28, 2012
Easy to use. Love the zoom and autofocus. Great value.
June 28, 2012
I was looking at a camera that was 2.5 times more expensive when I decided to try the sz-12 thinking that I might return it.
What a surprise! Great in every area. Total zoom is 96 times (24x4). Picture qualit is excellent. Easy to use and it is still small enough to fit in a pocket.
Try it before you spend much more on other cameras.!
Also impressed with the video.
June 28, 2012
I have only had the camera a few weeks and only used it a few times. I have a case and use it everytime the camera is not in use. Yet somehow the display screen is scratched already???
June 28, 2012
I love this camera. The zoom is amazing, the "magic" features are so much fun, and size is just perfect. It was a great birthday gift and I would recommend this to everyone ^_^
June 27, 2012
I love this camera! I initially got it to take pictures for my portfolio but its great for everyday use! I use this camera everyday I love that it has awesome zoom-in power! It came in handy for my graduation my family sat pretty far from the stage and they were able to zoom into the podium when I say the zoom-in power is awesome I mean it!!!! I love that it has the option to take many pictures at once with little kids or sports this comes in VERY handy! Wish I would have gotten it sooner!!!
June 27, 2012
I really like my new camera. It has been a few years since I bought my old one, and this one has so many new features. I like the unbelievable zoom lens. It is easy to use. All of the features are easy to use. I miss the paper owners manual, but the online one is acceptable. I tend to shake a little, but the camera makes the pictures look solid. I would definitely recommend this camera. I am sure after a few more weeks of looking up what it will do, and after taking it on vacation, I will give it even a greater recommendation.
June 26, 2012
This camera is worlds apart from our previous Olympus 5mp camera and has so many features that make great pictures easy to take. The price was good compared to many cameras that don't have nearly the same features. We love it.
June 25, 2012
Haven't used the camera much yet, just a few shots to get familiar. This camera take great pictures and has an awesome array of features for a camera its size. Easy to use, simple layout and the 24x telephoto zoom you won't find on many if any cameras in this class. Off to South America thursday for a month to give it a real workout.
June 25, 2012
I was looking for a camera with a high zoom. I am impressed with the 24X optical zoom. It's like I am right there, up close, taking the pictures.


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Oops, Someone Screwed Up: I Have My Own Blog
So through a series of mixups and comic blunders, someone has given me my own sports blog. It's over at NBCSports.com, and it launches tomorrow at 9 a.m. Title: Out Of Bounds. No, I don't know the exact url (they tell me very little), but it'll be promoted on their front page, I'm told. No need to knock; just come right in.
I should also say that this doesn't mean I'm leaving SbB … on the contrary, once I get things situated in the new place, I'll be here more than ever. I know that makes you happy … (hey! Who threw that brick?) Leaving SbB at this juncture is quite inconceivable, frankly. This site is going places; Brooks willing it to greatness through sheer heavy lifting and thought control. No one on the web is close to touching what he's accomplished over the past nine months, and I want to continue to be a part of that. The vibe here is electric. He is the lightning thief.
So, that's what's happening. Above please enjoy a screen capture of the Out Of Bounds logo, never before seen in the wild. No, I have no idea what's going on in it, or who those people are. All I can tell you is that if that's a Kansas City Chief there on the left, soon he will either be suspended or traded to Yahoo.


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My buddy Jota called me one saturday night and told me he had just met a girl in the club and at first of course I was like.... GOOD FOR YOU. sarcastically. Then he told me she wanted to be fucked while someone was filming her and then I totally got why he called me. I ran out of my house so fast I noticed later on I was wearing an unmatching pair of socks. WTF. Anyway. This girl was hot and is a naturally born porn star because she took anal like a pro. Bianka will definitely be back but this time with a friend and doing a thunderous threesome, hopefully with me.
"Meat Pole"
"Late Pick Up"
Suzana Scott
"Weekend Highlight"
Cinthia Santos
"Wild Stomp"
Sarah Lopes
"Red Devil"
Nicolle Bitencourt
"Nice To Know You"
"Lets Play House"
Milena Andrade
"Cougar Hunter"
"Going Downtown"
Bianca Lopes
"Sex Band"
Erica Martinelli


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Find the derivative of f(x) = log10 x.
We can rewrite this logarithm as
Since (ln 10) is a constant, the function f is a constant multiple of ln x:
We know how to find the derivative of this function:
Find the derivative of f(x) = log4 x2.
First, simplify the original function. We need to bring the exponent down in front, split up the logarithm, and combine all the constants into one:
Or, we could instead split up the logarithm first and then bring down the exponent (the order of these two operations doesn't matter):
Now we have a nicely rewritten function:
We've done an awful lot of work and haven't even started taking the derivative yet, but now, taking the derivative will be a piece of cake. The function f is a constant multiplied by ln x, therefore
We could make this even tidier by recognizing thatln 4 = ln (22) = 2 ln 2,therefore
Make it rain.
The who, what, where, when, and why of all your favorite quotes.
Go behind the scenes on all your favorite films.


text:
Scott Walker: No Wisconsin bill for gun background checks
Kristyna Wentz-Graff
Milwaukee Mayor Tom Barrett points to an ad from Armslist.com that Radcliffe F. Haughton allegedly placed to purchase a gun used in the Azana Salon & Spa shooting in Brookfield.
Gov. Scott Walker and a top Republican lawmaker made clear Thursday that GOP officials will block legislation in Wisconsin to expand background checks on gun sales. »Read Full Article


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Sony Alpha DSLR-A290
Announced Jun 9, 2010 •
14 megapixels | 2.7″ screen | APS-C sensor
Ask a question in forums about the Sony Alpha DSLR-A290.
Ask a new question
Posted to: Open Talk
Hi everyone, I'm a graphic designer and I delved into digital photography about 2 years ago. I'm currently shooting with a Sony A290. Didn't want to spend too much at first until I knew if I would really get into this. I'm totally hooked. :) So, I'm looking to upgrade my camera, and I'm deciding between the Sony A580 and the Pentax K-5. I primarily shoot landscapes and people, but not sporting events. I have done a few corporate photo shoots for my clients through my design work, but all...
I have sony A290 and somehow I have got a lots of dirt and other stuffs in my mirror and I tried to search video for cleaning tutorials but there are only sensors cleaning tutorials but no any mirror cleaning videos. So I would like to ask anyone of you if you know how to clean the mirror? or should I have to go to a specialist to clean it???thanks...........
okay, i know i am using an old camera, sony a290 but it should not give this result. i have several times made tried to make photos of waterfalls with no luck. i have slowed the shutter speed down and put on a ND filter but my photos keep gettig washed out completely. i can make 20 and one might turn out okay with an F32. i can never shot on f16 etc and especially below that. see below, f16 1.6 f22 s1.3 i finally got the shot (from above image) but had to use f32. why is this?...
Posted to: Beginners Questions
I just purchased my first ever DSLR after a lifetime of point and shoot, and I'm hoping I got a good model for my uses. I am a fine artist, and my primary goal with photography is to improve the reference photos I take for when I'm painting in the studio and not outside. My primary subject matter has been landscapes, but I've seen myself shifting to candid people shots, cafe scenes and city scapes now as well.I've read a ton of information on the CCD vs CMOS debate, and I decided I fell on...


text: RAND: Lisa S. Meredith 2016-01-27T07:21:20Z Copyright (c) 2016, The RAND Corporation RAND Corporation http://www.rand.org/about/people/m/meredith_lisa_s.html Association of Medical Home Team-Based Care Functions and Perceived Improvements in Patient-Centered Care at VHA Primary Care Clinics http://www.rand.org/pubs/external_publications/EP66290.html 2016-01-26T09:30:00Z 2016-01-26T09:30:00Z Team-based care is central to the patient-centered medical home (PCMH), but most PCMH evaluations measure team structure exclusively. We assessed team-based care in terms of team structure, process and effectiveness, and the association with improvements in teams' abilities to deliver patient-centered care. Validation of a Brief PTSD Screener for Underserved Patients in Federally Qualified Health Centers http://www.rand.org/pubs/external_publications/EP66273.html 2016-01-15T10:00:00Z 2016-01-15T10:00:00Z This study aims to validate the reliability and efficiency of alternative cutoff values on the abbreviated six-item Posttraumatic Stress Disorder (PTSD) Checklist (PCL-6) [1] for underserved, largely minority patients in primary care settings of Federally Qualified Health Centers (FQHCs). Family Resilience in the Military http://www.rand.org/pubs/research_reports/RR470.html 2015-07-10T08:00:00Z 2015-07-10T08:00:00Z Summarizes definitions of family resilience in the literature, identifies key family resilience factors, and recommends steps that the Department of Defense can take to manage its portfolio of family resilience programs and policies. The Most Used and Most Helpful Facilitators for Patient-Centered Medical Home Implementation http://www.rand.org/pubs/external_publications/EP50699.html 2015-05-14T09:00:00Z 2015-05-14T09:00:00Z Like other transformative healthcare initiatives, patient-centered medical home (PCMH) implementation requires substantial investments of time and resources. Emotional Exhaustion in Primary Care During Early Implementation of the VA's Medical Home Transformation http://www.rand.org/pubs/external_publications/EP50608.html 2015-02-25T10:45:00Z 2015-02-25T10:45:00Z Transformation of primary care to new patient-centered models requires major changes in healthcare organizations, including interprofessional expectations and organizational policies. Building Blocks for a Resilient City http://www.rand.org/pubs/infographics/IG119.html 2014-08-18T09:45:00Z 2014-08-18T09:45:00Z This infographic illustrates how communities can withstand and recover from disasters by building resiliency. Design of the Violence and Stress Assessment (ViStA) Study http://www.rand.org/pubs/external_publications/EP51821.html 2014-06-09T06:30:00Z 2014-06-09T06:30:00Z The Violence and Stress Assessment (ViStA) study is the first randomized controlled trial (RCT) to test the impact of a care management intervention for treating PTSD in Federally Qualified Health Centers (FQHCs). Road to Resilience http://www.rand.org/pubs/infographics/IG114.html 2014-05-23T14:15:00Z 2014-05-23T14:15:00Z This infographic illustrates how communities can become more resilient as they plan ahead for potential disasters. Huddle Up! http://www.rand.org/pubs/external_publications/EP66116.html 2014-01-01T12:00:00Z 2014-01-01T12:00:00Z In order to improve the impact of huddles on patient care, practice leaders should clearly communicate the goals, requirements, and benefits of huddling and provide adequate time and resources to ensure that frontline teams use huddle time to improve patient care. Road to Resilience http://www.rand.org/pubs/research_briefs/RB9747.html 2013-11-05T10:15:00Z 2013-11-05T10:15:00Z This infographic illustrates how communities can become more resilient as they plan ahead for potential disasters. Post-traumatic Stress Disorder in Vulnerable Populations http://www.rand.org/blog/2012/06/posttraumatic-stress-disorder-in-vulnerable-populations.html 2012-06-26T10:42:00Z 2012-06-26T10:42:00Z June is National PTSD Awareness Month and June 27th is PTSD Awareness Day, providing an opportunity to recognize the challenges faced by survivors of trauma who live with PTSD symptoms. RAND research is helping increase awareness about the disorder and inform policy about how to prevent and address it. Promoting Psychological Resilience in the U.S. Military http://www.rand.org/pubs/monographs/MG996.html 2011-06-27T09:00:00Z 2011-06-27T09:00:00Z Many programs are available to increase psychological resilience among service members and families, but little is known about their effectiveness. This report reviews existing programs to identify evidence-informed factors for promoting resilience. Prioritizing "Psychological" Consequences for Disaster Preparedness and Response http://www.rand.org/pubs/external_publications/EP201100191.html 2011-03-01T00:00:00Z 2011-03-01T00:00:00Z Health care facilities may be prepared to deal with the medical aspects of large-scale disasters but they lack guidelines for managing the psychological aspects of disasters. Building Community Resilience to Disasters http://www.rand.org/pubs/research_briefs/RB9574.html 2011-02-22T09:00:00Z 2011-02-22T09:00:00Z Examines ways in which communities can improve their ability to withstand and recover from adversity. Building Community Resilience to Disasters http://www.rand.org/pubs/technical_reports/TR915.html 2011-02-22T09:00:00Z 2011-02-22T09:00:00Z Provides a roadmap for federal, state, and local leaders who are developing plans to enhance community resilience for health security threats and describes options for building community resilience in key areas. Does Screening for Pain Correspond to High Quality Care for Veterans? http://www.rand.org/pubs/external_publications/EP20100106.html 2010-09-01T00:00:00Z 2010-09-01T00:00:00Z Despite routine pain screening in VA, providers seldom documented elements considered important to evaluation and treatment of pain. The Teen Depression Awareness Project: Building an Evidence Base for Improving Teen Depression Care http://www.rand.org/pubs/research_briefs/RB9495.html 2010-01-15T16:45:00Z 2010-01-15T16:45:00Z Presents findings from the Teen Depression Awareness Project, which explored how depression affects teens, the factors that influence teens' readiness to seek treatment for depression, and the barriers that teens and parents face when seeking care. Understanding Community Resilience in the Context of National Health Security: A Literature Review http://www.rand.org/pubs/working_papers/WR737.html 2010-01-11T17:02:00Z 2010-01-11T17:02:00Z This review lays a foundation for upcoming analyses that will provide a working definition of community resilience, identify activities for building resilience, and offer associated metrics. Nursing Staff, Patient, and Environmental Factors Associated with Accurate Pain Assessment http://www.rand.org/pubs/external_publications/EP20100161.html 2010-01-01T00:00:00Z 2010-01-01T00:00:00Z Although pain is a common reason for seeking medical care, pain screening at intake is often inaccurate. A Collaborative Approach to Identifying Effective Incentives for Mental Health Clinicians to Improve Depression Care in a Large Managed Behavioral Healthcare Organization http://www.rand.org/pubs/external_publications/EP20100135.html 2010-01-01T00:00:00Z 2010-01-01T00:00:00Z Giving incentives to mental health clinicians in managed behavioral health organizations to provide evidence-based care is feasible, but administrative barriers and limited clinical data may make implementation challenging.


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This website is running on a Microsoft IIS Server solution.
ASP.NET is a web application framework marketed by Microsoft that programmers can use to build dynamic web sites, web applications and XML web services. It is part of Microsoft's .NET platform and is the successor to Microsoft's Active Server Pages (ASP) technology.
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fairy horse by ShalladdrinWatch
©2010-2016 Shalladdrin
Made for a friend. Had fun incorporating wings for the first time.
All of your plushies are great! I really love this one though. The fairy wings are awesome!
Thanks! My friend commissioned it and helped design it, so part of the credit goes to her. I have lots of craft items stored away, and just happened to have one last pair of wings.
My daughter would never let me sleep if I could make things like these! Super cute and such tiny details.
You know... I have a fear of that when i get to have my own family... lol. Altho, i dont think I will mind! It's so much fun. I actually started making toys when i was about ten or twelve... it started with the Lion King and Redwall characters.
For awhile my daughter had me sewing all sorts of strange little plushies for her..LOL Thank goodness she has diverted her attention elsewhere...but if I drag anything out to sew she is right there in a flash to see what she can have mommy make her! LOL I get nothing done I tell ya. :}


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134 reviews
67% would repurchase
Package Quality: 4.2
Price: $$$
Package Quality: 4.2
Price: $$$
INGREDIENTS(((SAFTEY RATING OF 5 ON SKIN DEEP))) Water, phenyl trimethicone, cyclopentasiloxane, dimenthicone, PEG-9, polydimethylsiloxyethyl dimenthicone, glycerin, butylene glycol, sodium chloride, vinyl dimemthicone/mythilcone, silsesquioxane crosspolymer, trimethylsiloxysilicate, titanium dioxide, polyglyceryl-3 beeswax, talc, cetyl dimethicone, sorbitan sesquioleate, disrteardimonium hectorite, silica, dimenthicone crosspolymer, phenoxyethanol, alumina, sodium myristoyl glutamate, stearic acid, propylene carbonate, tetrasodium edta, dimenthicone/vinyl dimenthicone crosspolymer, ascorbyl glucoside, aluminum hydroxide, biosacchride gum-2, tin oxide, magnesium aspartate, zinc gluconate, hydrolyzed linseed extract, copper gluconate, rhodochrosite extract, sorbic acid. /- may contain: mica, CI 77002 (aluminum hydroxide) CI 77491, 77492, 77499 (iron oxides), CI 77891 (titanium dioxide)
Age: 36-43
Skin: Combination, Fair, Neutral
Hair: Red, Wavy, Fine
Eyes: Green
Creases like a...yeah. Twelve letters. Sounds like "brothertrucker". If you're that keen on owning something with DIOR slapped on it, may I suggest pretty much anything else from the line? Lipstick. Blush. Shadow palettes. Even foundation. This concealer may be more compatible with a drier skin, but I personally need something that's going to stay put and offer some actual coverage in the bargain. Lancome Effacernes, Maybelline Age Rewind, Collection Lasting Perfection...my track record with undereye camouflage is a joke, but these represent the best luck I've had so far. Godspeed, my oily-combo sisters.
Age: 19-24
Skin: Combination, Fair, Warm
Hair: Brown, Wavy, Fine
Eyes: Blue
The best thing about this concealer, for me, is the texture. I have dry skin and A LOT of concealers and foundations look super cakey on me. This, however, blends easily and looks amazingly natural (probably because it doesn't dry to a powder finish.) The coverage is light, which I prefer for covering redness on my face, but it's far too sheer to use on my zombie-like dark circles. The only real downside for me is that it doesn't last very well. My skin doesn't really "eat" product, but after 6-8 hours, it's started to disappear, particularly from my nose.
The packaging is also great. It's just a simple squeeze-tube, but I think that's simpler and more hygienic than a doe-foot applicator or pot.
Overall, I like this concealer and will happily use it up, and may one day re-purchase it, but I'm going to look for something better.
Age: 25-29
Skin: Combination, Tan, Not Sure
Hair: Other, Other, Other
Eyes: Brown
Really dislike this concealer, for the price I was expecting something to blow my socks off.
Unfortunately, this concealer was wayyyy too greasy, did not blend well at all, and barely covered.
When you squeeze the tube, sometimes the oil and concealer separate forcing you to mix them together. Then you apply it, its doesn't blend just sort of sits on top of your under eyes and creases very easily.
What a waste of money!
Age: 19-24
Skin: Combination, Fair, Neutral
Hair: Brunette, Straight, Medium
Eyes: Blue
Of course, when a product is quite pricey, I have higher expectation. About this Dior concealer, I can't say it is a really bad product - my sister love it in fact - but I was quite disappointed. I was searching for a good coverage concealer that would not settle in my fines lines and would have a good staying power. I was quite desperate, and the women at Sephora said it was her HG concealer. For me, it was nothing but ok. I already take good care of my skin and eyes area so the hydrating formula was not the point. It did conceal a little, but nothing like the miracle I was expecting for the words of the woman. It sure did not work as well as the Maybelline Fit Me concealer or the Wake Me Up/Match Perfection Rimmel ones. I will just not repurchase this one, due to my appreciation and the price. At least, I made an happy girl of my sister by giving it to her. Not awful but not amazing, it is an OK product for me.
Age: 44-55
Skin: Sensitive, Fair, Cool
Hair: Black, Wavy, Fine
Eyes: Black
This is too light for covering undereye dark circles, although it does not cake or crease, as compared to some others such as Bobby Brown concealer, Maybelline mineral concealer, Revlon concealer stick, Benefit Erase Paste)
Age: 18 & Under
Skin: Combination, Fair-Medium, Neutral
Hair: Brunette, Wavy, Medium
Eyes: Blue
It's an okay concealer but it does not cover a lot and wears off easily so its definitely not worth the price. Better concealers can be found at the drugstore.
Age: 25-29
Skin: Combination, Other, Not Sure
Hair: Brown, Other, Other
Eyes: Brown
I had been looking for another Dior product which was sold out, so a friend suggested that I give this concealer a try. I was reluctant at first, it's a small tube and I was sure I would use it really quickly.
But I decided to give it a try. I purchased a shade lighter than my skin for my under eye and I'm very happy with the results. I just use two small dots for both eyes and it magically brightens my face. I use it as a highlighter and I think it works even better than the YSL eclat. I'm able to control the amount that comes out easily. The base is creamy and it's not drying.
The only con is that there isn't much of a color selection, but if it works for your skin tone, it blends beautifully.
Age: 25-29
Skin: Normal, Fair, Not Sure
Hair: Black, Other, Other
Eyes: Brown
This is not a bad buy, at least I really feel more hydrating than the other concealer stick. The coverage is good enough for me as I don't have a lot of dark circle or pimple. I just feel that with the price the content is really fast to finish. I used Bobbi Brown touch up stick, the stick lasts forever, but this one I feel I would finish it in no time. It's great for winter time as it keeps your skin hydrates but I would still prefer Bobbi Brown for its value.
It's great for someone that doesn't need heavy coverage.
Age: 18 & Under
Skin: Acne-prone, Fair, Neutral
Hair: Brunette, Wavy, Coarse
Eyes: Brown
I don't have too much experience with under-eye concealers but I can say this one does everything I would want it to. I bought it in shade 001 and my actual skin tone is probably closer to that of 002 but I wanted it to be a bit lighter to give a "highlighting" look. This concealer does that while covering up dark circles and it doesn't crack throughout the day or completely fade away either. It's expensive but I believe in getting what I pay for and this product is just that.
P.S. I probably wouldn't suggest this to be used to cover scars or acne as it has a kind of dewy look and would only draw attention to those imperfections.
Age: 30-35
Skin: Combination, Fair-Medium, Not Sure
Hair: Red, Other, Other
Eyes: Green
Been using this since it was released. .had used ysl radiant touch but too thin and not enough product in the pen. Doesn't crease in lines and is buildable.
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KIOSK is a travel story depicted through objects, a collection of interesting things from around the world, a study of material culture, a shop, several people's efforts to preserve unique and indigenous objects, an installation, maybe just something other than what we are used to.
This almost-secret curiosities shop stocks nifty (and inexpensive) utilitarian items collected from countries around the world. Mon-Sat: 12-7pm
Follow the Amazon Bird calls upstairs to this oasis 4 international design trinkets. Building is being demolished & store is relocating soon. Go! #KIOSKKIOSK
The guy at the counter is so nice! Wrapped my gift purchase for me at no charge. Really interesting pop up store
In a neighborhood where stores with similar a similarly curatorial approach to merch are super expensive, Kiosk has some cool cheap stuff--but could annotate their products a little less murkily.
World of deaigns...
Lovely little boutique
This is my secret place. "Somewhere only we know."
Love the hallway
If you are looking for unusual stores in Soho, Kiosk is the right place for you. Little design store with selection of cool stuff and gifts. Worth a visit.
Beautiful everydayish stuff from all over the world
A tiny museum of everyday objects you'd find in hardware and corner stores home and abroad. You'll discover things you never knew you needed and now can't live without.
This amazing museum-like store is loaded with novelty items from all over the world!
eu gostaria de ser o dono desta loja. uma das lojas mais criativas que conheço. I want to be a owner of this awesome and creative place.
This secret spot is full of international home pieces (red lamp shades from Hong Kong, wooden utensils from Sweden), all displayed on illuminated shelves with typed-up tales of the item's origin.
Head up the stairs on Spring and check out this dazzling display of (mostly) diminutive design highlights from around the world. From Japanese pens to German kitchenware.
Best place EVER for unique last-minute affordable gifts. Did I say unique? This is what every little pillow/trinket shop in Brooklyn WISHES it could be.
A lovely bunch of things. Bird call, Kite and Ice cream scoop. Christmas shopping done!
Yes, those sketchy, graffiti-lined stairs lead to an amazing exhibition-style second floor filled with geography-themed curiosities. Perfect for gift shopping, you'll be glad you were brave.
Great place for everyday, colorful design. Follow the big pink arrow to find the entrance.
cheap random gifts, candy is better. buy some icelandic candy today
Best gifts/trinkets tet
If you are in Soho, make the trip up the stairs to find a super eclectic design store.


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Romans 12:10-13King James Version (KJV)
10 Be kindly affectioned one to another with brotherly love; in honour preferring one another;
11 Not slothful in business; fervent in spirit; serving the Lord;
12 Rejoicing in hope; patient in tribulation; continuing instant in prayer;
13 Distributing to the necessity of saints; given to hospitality.
King James Version (KJV)
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text:
2012 Hyundai Genesis User Reviews
2012 Hyundai Genesis Review Rankings
User Reviews
Displaying all 3 2012 Hyundai Genesis reviews.
CarGurus http://www.cargurus.com
Matthew writes:
2012 Hyundai Genesis 5.0L R-Spec Review
Fast. Loaded with features.
Mileage is about 20-21 mpg for me - commuting 90 miles/day.
Genesis R-spec — The performance of the car is stellar. Once you drive the Genesis R-Spec nothing else will compare. Strong acceleration on tap. Emergency auto braking kicked in on the 405 freeway one day - avoided an accident. Bluetooth and nav easy to use.
Primary Use: Commuting to work
Looking for a Used Genesis in your area?
CarGurus has 9,873 nationwide Genesis listings starting at $7,999.
CarGurus http://www.cargurus.com
nlemarquand writes:
2012 Hyundai Genesis 5.0L R-Spec Review
Unbelievable machine ! 28 mpg on hwy
paint chips easy
Displaying all 3 2012 Hyundai Genesis reviews.
Reviews From Other Years
2015 Hyundai Genesis Reviews
very good car for the money and a very good waranty,i havent had the car for a long time but it looks promising, the color is a beige they call it beige marrkesh, and the interior is a two tone beige Read More
2011 Hyundai Genesis Reviews
Great Car For The Price
love the strong acceleration - while at the same time miserly fuel economy. BMW, Mercedes can't match the technology. Doors sound solid as a rock when closing. Quiet, luxurious ride. Confident and s... Read More
First-class Car. A Dream On Wheels.
My friends, my family, my kids' friends, total strangers -- they all comment on how beautiful this car is and how spacious and comfortable it is on the inside. Built with precision and excellence in ... Read More
2010 Hyundai Genesis Reviews
Awesome Car For A Hyundai
Hyundai has come a long way since the 80's. This car is comparable to the Lincoln Town Car as far as quality, space, ride and size. This has a slightly smaller wheel base than the Lincoln and smaller ... Read More
Buy One
Fun to drive at thousands less than a comparable car. Flawless quality. An interior with true craftsmanship touches and a killer Lexicon (optional) sound system. Surprisingly good mileage 18-22 blende... Read More
2009 Hyundai Genesis Reviews
A Fantastic Car!
I purchased this car brand new in 2009. Absolutely satisfied with the car. I have had 2 notes with telephone numbers from anonymous admirers of this car placed under the windshield wipers within the f... Read More
It Only Costs How Much?
I really like the body style and overall size of the car. It is so spacious. Overwhelmingly loaded with standard features that only come as extras in other luxury vehicles. I wish there was more wood ... Read More


text:
Khloe Kardashian and French Montana are living wild, dolls!
The Keeping Up With the Kardashians star and her rapper beau took a safari in South Africa Monday, reveling in the chance to get up close and personal with the region's beautiful wildlife.
The pair, joined by singer Miguel and another pal, Instagrammed photos of the wildlife and the people they encountered on their adventures. French even shared a video of what appeared to be some natives performing a dance for their famous visitors, writing, "Sometimes you don't know how blessed you are. #grateful #southafrica"
NEWS: Kris Jenner talks Rob Kardashian's struggles, Khloé Kardashian's romance with French Montana
All three of the fellas—and Khloé—proved they could do safari chic, too, pairing their casual ensembles with the outdoorsy pith helmets traditionally worn on this type of outing.
French might've been the bravest of all, though (or at least, he got the best photo proof of his badass behavior)! The rapper Instagrammed a photo of himself standing just feet in front of a super sized giraffe, proclaiming he'd "Had a blast in Africa" but was now heading "back to NY."
It's convenient that French, who moved from Casablanca to the Bronx at age 13, and Khloé, an L.A. transplant currently opening a Dash pop-up on the East End, are both New York-based for the summer. Summer is the city is...something else, but French can train, Jitney or helicopter his way on out to Southampton (where his girl is filming Kourtney & Khloé Take the Hamptons) in no time!
The sights out there aren't quite as spectacular as the ones they saw on their South African safari, but Hamptons people watching cannot be beat!
Tune-in for a brand new episode of Keeping Up With the Kardashians next Sunday at 9/8c on E!


text:
Office: Gyte 284
Telephone: (219) 989-2738
E-Mail: email@example.com
Research Interests:
My research focuses on a fundamental aspect of genetics – differential gene expression, a process by which each cell expresses a unique subset of its genes at the correct time and in the correct location. This process is regulated in part by a group of cis-regulatory genomic sequences known as enhancers. Enhancers are sequences of DNA which generally do not code for protein, but rather control when, where, and how much a gene expressed through interaction with specific transcription factors. These sequences have been identified in all examined forms of life: viruses, bacteria, yeast, multicellular animals and plants all use this strategy to control gene expression. However, our knowledge of enhancer action remains far from complete. For example, we do not fully understand the rules that govern the structure and function of these DNA elements. We also do not know what combinations of biochemical activities sufficient for enhancer action. My research seeks to elucidate some of these gaps in our current knowledge of enhancer action.
- Ph.D. Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, 2012
- B.S. Biology emphasis in Cell and Molecular Biology and Genetics, Grand Valley State University, Allendale, Michigan, 2005
Professional Society Memberships
- Society of Developmental Biology 2012-2015
- Genetics Society of America 2010-Present
- American Society of Developmental Biology 2004-2006
- Association for Biological Laboratory Education 2014- Present
Evans, N.C., Swanson, C.I., Barolo, S., sparkling insights to enhancer sparkling Insights into Enhancer Structure, Function, and Evolution. Transcriptional Switches During Development (CTDB Vol. 98) February 2012
Swanson, C.I., Evans, N.C., Barolo, S., Structural Rules and Complex Regulatory Circuitry Constrain Expression of a Notch- & EGFR Regulated Eye Enhancer. Dev Cell. 2010, 18(3): 359-370 *Selected as a "Must Read" by Faculty of 1000 Biology and Science "Editors' Choice," 16 April 2010.
- BIOL 10200 – Introductory Biology
- BIOL 24400 – Genetics
- BIOL 49500 – Experimental Design
- BIOL 50700 – Molecular Biology
- BIOL 59500 – Medical Genetics


text:
Originally posted by Flinx
He looks asleep or passed out....
Originally posted by Nerdling
i wonder why they suddenly decided to drag this back up at this time *raises brow*
This content community relies on user-generated content from our member contributors. The opinions of our members are not those of site ownership who maintains strict editorial agnosticism and simply provides a collaborative venue for free expression.
All content copyright 2016, The Above Network, LLC.


text:
- Tapered Shade
- Fixture Directs Illumination In a Downward Direction
- Full ranging dimming capabilities allow you to choose the right amount of light for every situation
Lamping Technologies:
- Bulb Base - Medium (E26): The E26 (Edison 26mm), Medium Edison Screw, is the standard bulb used in 120-Volt applications in North America. E26 is the most common bulb type and is generally interchangeable with E27 bulbs.
- Compatible Bulb Types: Nearly all bulb types can be found for the E26 Medium Base, options include Incandescent, Fluorescent, LED, Halogen, and Xenon / Krypton.
- Number of Bulbs: 1
- Bulb Base: Medium (E26)
- Bulb Type: Incandescent
- Bulb Shape: A19
- Bulb Included: No
- Watts Per Bulb: 100
- Wattage: 100
- Voltage: 120
- Height: 12.4"
- Depth: 7.5"
- Width: 7.5"
- Chain Length: 12"
- Wire Length: 1"
- UL Listed: Yes
- UL Rating: Damp Location
- 365705 (This Model)
- 365710 (Large Model)
- UL Listed - Indicates whether a product meets standards and compliance guidelines set by Underwriters Laboratories. This listing determines what types of rooms or environments a product can be used in safely.
Additional Hubbardton Forge Links
This Hubbardton Forge item can also be referenced by the following color/finish specific model #:
- Hubbardton Forge 365705-10
- Hubbardton Forge 365705-05
Hand-Rubbed Bronze
- Hubbardton Forge 365705-07
Hand-Rubbed Dark Smoke
- Hubbardton Forge 365705-03
Hand-Rubbed Mahogany
- Hubbardton Forge 365705-20
Natural Iron
- Hubbardton Forge 365705-08
*Discontinued model or finish
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text: Surgery - Dunedin http://hdl.handle.net/10523/576 2016-02-14T20:55:40Z 2016-02-14T20:55:40Z The microRNA profile of aortic stenosis Coffey, Sean http://hdl.handle.net/10523/5799 2015-07-12T21:20:10Z 2015-07-12T21:19:41Z The microRNA profile of aortic stenosis 2015 Coffey, Sean Background Valvular heart disease (VHD), especially aortic stenosis (AS), is an important cause of morbidity and mortality, but no medical therapies currently exist for most forms of VHD. The only treatment available for severe AS is valve replacement, a procedure that often carries significant risks. There is little information available regarding how the disease burden due to VHD has changed over time Calcific aortic valve disease (CAVD) is the process underlying AS. Early CAVD leads to thickening and/or calcification of the aortic valve without causing a significant pressure gradient– this is diagnosed as aortic sclerosis on cardiac imaging. Despite this lack of haemodynamic effect, aortic sclerosis has previously been associated with an increased risk of some cardiovascular events, but not stroke. The aims of this thesis were, firstly, to investigate the changing epidemiology of VHD by assessing VHD mortality rates, secondly, to more accurately define the risks associated with aortic sclerosis, and finally, to examine the molecular biology of CAVD, in an attempt to find new therapeutic avenues to explore in the future. Methods Cause of death information for New Zealand and the United States of America was used to assess trends in mortality rates due to VHD. A systematic review and meta-analysis of high-quality prospective observational studies was performed to accurately delineate the epidemiology and risks of aortic sclerosis. Micro-ribonucleic acid (microRNA) profiling was used to examine the molecular biology of CAVD. MicroRNAs are short sequences of nucleotides that are slow to degrade even after significant periods of time post-mortem. Post-mortem aortic valve specimens were therefore compared to diseased aortic valve tissue obtained at the time of aortic valve replacement. Circulating microRNA profiles were compared between participants with and without AS. Results Mortality rates due to VHD increased throughout the 1990's until stabilising in the first part of the 21st century, with a similar trend seen in New Zealand and the United States. Most of the mortality was due to aortic valve disease. Population projections suggest that, unless mortality rates decrease in the future, there will be a dramatic increase in numbers dying of VHD over the next few decades, due to an ageing population. The prevalence of aortic sclerosis increases approximately linearly with the age of the population studied. It progresses slowly, and uncommonly leads to clinical AS. Despite this, on meta-analysis, aortic sclerosis was associated with an increased risk of all examined cardiovascular events, including stroke. MicroRNA tissue profiling showed clear differences between diseased and control aortic valves, with suppression of miR-122-5p and increased expression of miR-21-5p. Circulating microRNA profiles, while showing differences between those with and without AS, did not have favourable properties for use as a biomarker. Conclusions VHD, and in particular AS, is projected to be a major cause of death and disabililty over the foreseeable future. A number of new avenues of investigation have been raised by the microRNA studies undertaken, with the aim being to develop new medical therapies for AS. 2015-07-12T21:19:41Z Biomarkers for abdominal aortic aneurysm Jin, Cao http://hdl.handle.net/10523/5714 2015-06-14T23:06:11Z 2015-06-14T23:05:21Z Biomarkers for abdominal aortic aneurysm 2015 Jin, Cao i Abstract Background Abdominal aortic aneurysm (AAA) represents a significant health burden, affecting approximately 4% of men over the age of 65 years in western countries. To date, no clinically useful circulating AAA biomarkers have been identified. In order to address this problem, a preliminary proteomics analysis was conducted in our research lab to compare differences between aneurysmal and non-aneurysmal abdominal aortic tissues, with a total of ten differentially expressed proteins being identified. This thesis aimed to investigate whether some of these putative biomarkers could be validated. Furthermore, the subsequently validated (tissue) proteins were also examined in a more clinically relevant setting, as circulating biomarkers for AAA, to better test their potential utility. Methods Initially, a preliminary 2D-PAGE/mass-spectrometry analysis was performed on AAA (n=7) and control (n=3) abdominal aortic adventitial layer homogenates. A total of ten differential proteins were identified. Based on the literature four of the proteins, including 14-3-3 θ, 14-3-3 β, heat shock protein-27 (Hsp27) and serum amyloid protein p component (SAP), were chosen for validation. In the first study, two methods were chosen for the validation of 14-3-3 θ, 14- 3-3 β, using 14-3-3 γ as a comparative control isoform. Initially, these three 14-3-3 isoforms were examined by western blot in tissues from 82 AAAs and 16 controls. Subsequently, the three isoforms were also quantified in 36 AAAs and 30 controls using a commercially available ELISA kits. In a second study, in order to provide a better understanding of 14-3-3 isoforms and to test their utilities as potential clinically useful biomarkers, plasma samples were measured using ELISA. In addition, separate layers of aortic walls (intima/media & adventitia) were also examined. Immunohistochemistry was also performed to localize the tissue expression of 14-3-3 proteins. In a third study, the potential functions of 14-3-3 isoforms, specifically on cell proliferation and apoptosis, were tested in Jurkat T lymphocytes and vascular smooth muscle cells by inhibiting protein expression using small interference RNA (siRNA) which targeted specific 14-3-3 isoforms. Finally, both Hsp27 and SAP were examined in abdominal aortic wall tissues from both AAAs and controls (20 of each). In addition, 10 samples from each group also had separate micro-dissected adventitia and intima/media specimens examined. Plasma Hsp27 and SAP were also tested in an elderly cohort of 280 subjects, which included otherwise healthy controls, AAA, CAD and PAD patients. Results (1) Western blot and ELISA analysis confirmed that 14-3-3 θ had significantly higher protein expression in AAA wall homogenates compared with controls (P<0.01). Subsequent ELISA analysis on separate aortic wall (adventitial and intimal/medial) layers and immunohistochemistry indicated that 14-3-3 θ was predominantly localized within adventitial T-cell rich lymphoid aggregates. Plasma analysis failed to detect 14-3-3 θ in either AAA or controls. (2) Treatment of T-cells with 14-3-3 θ siRNA appeared to lead to slowed cell growth, however, this effect was not observed in vascular smooth muscle cells. (3) Tissue Hsp27 appeared elevated in adventitia, media and total walls of AAA tissues compared to elderly controls (P<0.01). Plasma Hsp27 levels were significantly lower in all arterial disease patients, including CAD, PAD and AAA, compared with otherwise healthy elderly controls (P<0.01). Conclusion Our 2D-PAGE and subsequent validation studies revealed significantly increased 14-3-3 θ in AAA tissues. 14-3-3 isoforms are known anti-apoptotic proteins, whose association with adventitia lymphocytes may prolong T-cell survival and thereby contribute to the characteristic enhanced adventitial inflammation observed in AAA. Unfortunately, the inability to detect 14-3-3 θ in the circulation may suggest that this protein has limited potential as a disease biomarker. Nevertheless, this study promotes our understanding of the pathobiological mechanisms underlying the formation of abdominal aortic aneurysm and may offer a novel potential therapeutic target. 2015-06-14T23:05:21Z Circulating MicroRNAs in Bariatric Surgery Chan, Cheng Yee http://hdl.handle.net/10523/5023 2014-10-09T19:40:18Z 2014-10-09T19:38:25Z Circulating MicroRNAs in Bariatric Surgery 2014 Chan, Cheng Yee Obese patients who undergo gastric bypass surgery experience metabolic changes resulting in appetite loss and the apparent disappearance of type II diabetes within days to weeks, even before weight loss occurs. The biological mechanisms underlying these changes are not well-understood. This study aimed to investigate the change in circulating microRNAs that correspond to these metabolic effects. MicroRNAs are a recently-discovered class of small regulatory molecules that play a key role in diverse biological processes, including lipid metabolism and insulin regulation. It was hypothesised that the microRNAs that change uniquely in association with bariatric surgery will be involved with the modulation of expression of genes in metabolic pathways that produce the physiological changes observed post-operatively. The overall study comprised two phases, a discovery and a validation phase. The discovery phase formed the basis of this thesis. Three groups were recruited, a Bariatric group, consisting of obese patients undergoing gastric bypass surgery, and an obese Control group and a lean Control group, consisting of patients undergoing non-bariatric surgery. For the discovery phase, both Control groups were combined into a single Control group. Fasting blood samples were taken from twelve patients in each of the Bariatric and combined Control groups at baseline, 5 days and 6 weeks post-operatively, for microRNA analysis. Patient demographics and markers of surgical response including anthropometric measures (weight, body mass index, waist-hip ratio), glycaemic parameters (insulin, HbA1c, fasting glucose), fasting lipid profile, hs-CRP, blood pressure and results of an appetite questionnaire were recorded at each time-point. Affymetrix GeneChip arrays were used to generate microRNA profiles that were compared between samples. The Qlucore software package was used to identify differentially-expressed microRNAs by principal component analysis and hierarchical clustering. MicroRNAs specific to the post-operative Bariatric group were determined, and linked to the unique obesity-related metabolic changes. The validation phase involves replication of the specific microRNA changes detected in the discovery phase in a larger number of Bariatric and Control patients at all time-points previously assessed (baseline, 5 days and 6 weeks), as well as at 3 months and 1 year post-operatively, using microRNA-specific Taqman assays. This is currently ongoing. Discovery phase results revealed 7 differentially-expressed microRNAs at 6 weeks in the Bariatric group, and 22 at the same time-point in the Bariatric diabetic sub-group. These were associated with significant clinical improvements in weight, glycaemic parameters and appetite scores at 6 weeks. In contrast, there were no differentially-expressed microRNAs at 5 days in the Bariatric group, or at either time-point in the Control group. MicroRNA-associated gene ontology and predicted pathways analysis identified regulatory associations with genes known to be involved in potentially biologically-plausible roles encompassing adipogenesis, pancreatic β-cell regulation, insulin signalling and secretion, and appetite control. These roles appear consistent with the metabolic effects seen following gastric bypass surgery: weight and adipose tissue loss, improved insulin sensitivity and glucose metabolism and decreased appetite. This work requires further validation; however, it indicates the therapeutic potential of altering levels of these unique microRNAs as novel pharmacological mechanisms that may mimic the effects of bariatric surgery. 2014-10-09T19:38:25Z The Parapharyngeal Compartment and its Fascial Relations Guidera, Alice K http://hdl.handle.net/10523/4417 2013-11-11T20:05:11Z 2013-11-11T20:02:23Z The Parapharyngeal Compartment and its Fascial Relations 2013 Guidera, Alice K Introduction An accurate understanding of the arrangement of cervical fascia and its associated compartments is essential for differential diagnosis, predicting the spread of disease and surgical management. As surgical technology advances it becomes imperative to have a thorough understanding of the anatomy of these compartments. Current descriptions of one such compartment, the parapharyngeal compartment (PPC), are inconsistent in terms of its borders, communications and contents. Methods This thesis comprises two main elements. Firstly, a review of descriptions of cervical fascia in contemporary reference texts recommended by the Royal Australasian College of Surgeons, followed by a detailed review of the scientific and clinical literature. Secondly, an investigation of the anatomy of the PPC utilising a combination of techniques: cadaver dissection of 10 half heads (eight embalmed, two fresh; 3 male, 7 female; mean age 81 years) via several different approaches (lateral to medial, medial to lateral [transoral], and posterior to anterior); serial histological sections in two additional half heads; and magnetic resonance imaging (MRI) of cadaver specimens and 20 patients (9 male, 11 female; mean age 53 years) independently and blindly analysed by an experienced head and neck radiologist and the author to compare fascial arrangements seen on MRI and dissection. Results The current terminology used to describe the cervical fascia and its compartments is replete with confusing synonyms and inconsistencies, creating important interdisciplinary differences in understanding. Analysis of the scientific and clinical literature revealed numerous anatomical controversies relating to the PPC. Dissection findings showed that the PPC has a dihedral shape, tapering to a point superiorly at the skull base, widening in its central portion, and tapering to its inferior limit at the greater cornu of the hyoid bone. The lateral and superior boundary of the PPC was formed by the tensor veli palatini muscle, which was intimately related to the medial pterygoid muscle. Structures lying between the tensor veli palatini and medial pterygoid muscles were contents of the masticator compartment. The carotid sheath formed a distinct, robust fascia separating the PPC and carotid compartment. There was no 'styloid diaphragm' encompassing the styloid process and its associated muscles. However, the styloid muscles are key contents of the PPC that can be used to guide surgical dissection. The PPC also contained fat and neurovascular structures. It communicated with the submandibular compartment in all specimens, with the parotid compartment in some, but a communication with the carotid and retropharyngeal compartments was not identified. Conclusions A revised nomenclature underpinned by evidence-based anatomical and radiological findings is proposed in order to enhance understanding of the cervical fascia and its compartments and facilitate clearer interdisciplinary communication. The three-dimensional anatomy of the PPC is complex; it is a deep compartment that is difficult to access and not oriented along traditional imaging planes. This study has clarified the borders, communications and contents of the PPC, which should help to optimise minimally invasive surgical approaches (particularly transoral approaches), intraoperative orientation within the compartment, and reduce the risk of inadvertent damage to regional neurovascular structures. 2013-11-11T20:02:23Z Pathway based-approach for analysis of the New Zealand genome-wide association study in abdominal aortic aneurysm Yu, Zhuo (Grace) http://hdl.handle.net/10523/3803 2013-03-25T20:05:14Z 2013-03-25T20:04:22Z Pathway based-approach for analysis of the New Zealand genome-wide association study in abdominal aortic aneurysm 2013 Yu, Zhuo (Grace) Background: Abdominal aortic aneurysm (AAA) is a life-threatening disease with a strong genetic component that predominantly affects elderly males. Previous genome-wide association studies (GWAS) have identified a number of genetic markers with large effects contributing to disease susceptibility. However, the understanding of AAA pathogenesis remains incomplete. This thesis investigated the role of genetic variations in two pathways in the New Zealand AAA GWAS, the transforming growth factor beta (TGF-β) signaling pathway and the combined dyslipidemia/coronary artery disease pathway, to gain more understanding of the biological insights in AAA. Methods: The New Zealand discovery GWAS was performed using DNA samples from 621 AAA cases and 627 controls matched for age and gender. The Affymetrix genome-wide human single nucleotide polymorphism (SNP) 6.0 arrays were used, and suitable quality control assessments of the resulting genotyping were conducted to raise genotyping accuracy. Candidate genes from each pathway were selected based on either the biological activities (TGF-β pathway) or on previous evidence with risk association in other cardiovascular conditions (dyslipidemia/coronary artery disease pathway). A multi-staged analysis was conducted as putative associations identified in the discovery GWAS were then followed up in an additional New Zealand AAA cohort using Taqman genotype assays. Further replication (in silico) of associations of candidate SNPs with AAA was carried out in additional international AAA populations. The specificity of putative associations with AAA was assessed by adjusting for common cardiovascular risk confounders. Results: The New Zealand AAA achieved an average genotyping call rate of 99.2%, and genotype imputation yielded over 3 million SNPs with an quality score greater than 0.90. In the TGF-β pathway, the New Zealand AAA discovery GWAS identified a significant association in the transforming growth factor receptor III (TGFBR3) gene, also known as betaglycan. The minor A allele of the leading SNP rs11165595 in the TGFBR3 showed an increase in AAA risk in a recessive model (OR 1.39; 95% CI, 1.18-1.64; p = 9.1x10-6). Conflicting findings were observed when the association was validated in a secondary New Zealand AAA cohort. Genotyping analysis from additional international AAA studies showed consistent findings with the New Zealand discovery GWAS (OR 1.10; 95% CI, 1.04-1.17; p = 0.0017) In the combined dyslipidemia/coronary artery disease pathway, the discovery GWAS identified twelve SNPs with significant associations with the risk of AAA. The genetic associations were investigated further in a secondary validation AAA cohort. The minor G allele of rs599839 in the 1p13 locus showed association with the risk of AAA (OR 0.75, 95% CI, 0.64-0.88; p = 1.8x10-4), despite its likely confounding effects on other cardiovascular conditions. The meta-analysis of this association with additional international AAA studies showed consistent observations (OR 0.83; 95% CI, 0.77-0.88; p = 3x10-9). Conclusions:A genome-wide association study has been successfully conducted in the New Zealand AAA case-control cohort. Genetic associations identified in TGFBR3 and 1p13 loci suggested potential genetic predispositions in AAA. The pathway-based approach was shown to be a useful tool to uncover genetic associations with moderate effects, and this approach may be more appropriate to define AAA risk than a single SNP test. The findings in this study may provide a future direction for identifying more genetic variants contributing to the risk of AAA. 2013-03-25T20:04:22Z A novel set of condition-specific quality of life questionnaires in elective general surgical patient prioritization and outcome assessment Chen, Tina Yen-Ting http://hdl.handle.net/10523/2588 2013-02-14T04:22:20Z 2012-11-12T00:55:04Z A novel set of condition-specific quality of life questionnaires in elective general surgical patient prioritization and outcome assessment 2012 Chen, Tina Yen-Ting Health-related quality of life (QOL) has become an indispensible measure of health. It is an important patient-reported outcome (PRO) endpoint for elective surgery, and is one of the key factors in determining patient priority for elective surgery. In general surgery, there has been a lack of suitable condition-specific QOL instruments to effectively evaluate PRO of elective treatment, examine the current patient prioritization system for elective treatment, and investigate the role of QOL in relation to clinical and other more objective measures of health. In response to the above, this thesis documents the development, validation, and application of the "Otago Condition-Specific Questionnaire" (OCSQ). The OCSQ is a novel, standardized set of condition-specific QOL instruments tailored for general surgery, and specific for some common elective general surgical conditions, including anorectal conditions, gallstone disease, abdominal wall hernias, varicose veins, and colorectal conditions. The OCSQ was developed based on an extensive conceptual model of condition-specific QOL, thorough literature review, as well as clinician and patient input. It was validated with rigorous psychometric tests, and was shown to be practical, valid, reliable and responsive. The QOL information obtained with the OCSQ was correlated against clinical, physiological, and sonographic measures of disease severity in the setting of varicose veins. It was found that QOL related poorly to the objective measures, indicating that QOL is independent of these measures, and can broaden the scope of patient assessment by complementing these measures with a unique facet of information rooted in the patient's subjective perception. The OCSQ was used to assess the PRO in a large cohort of patients over a three-year period following elective general surgery. In addition to QOL, the OCSQ was also designed to obtain other PRO information, including patient satisfaction with treatment, patient-perceived treatment-related problems, and duration until return to usual activities after treatment. Overall, PRO was found to be satisfactory. The OCSQ was shown to be valuable in monitoring treatment efficacy, in identifying patients with suboptimal QOL outcome, and in facilitating the comparison of PRO between different conditions and treatments. The OCSQ was also used to explore how well QOL was represented in the patient's priority to accessing elective general surgery. It was found that QOL had no bearing on the patient's priority status. Patients with different levels of QOL had similar priority. The surgeon's assessment of QOL was not in keeping with the patient's own view of QOL, and the surgeon did not incorporate his or her assessment of QOL into the final judgement of priority. The OCSQ could help in improving the integrity of patient prioritization by being an integral part of the priority scoring tool, as well as the cognitive feedback package presented to surgeons to enhance their priority scoring performance. 2012-11-12T00:55:04Z Defining appropriateness of emergency department attendance: a New Zealand perspective Richardson, Sandra Kathryn http://hdl.handle.net/10523/2469 2015-04-28T09:49:00Z 2012-09-28T02:29:44Z Defining appropriateness of emergency department attendance: a New Zealand perspective 2012 Richardson, Sandra Kathryn Aim: To explore NZ emergency medical and nursing staff understandings of Emergency Department (ED) 'appropriateness' in relation to patient presentations. Background: This study was developed in order to contribute to the knowledge and practice responses around ED overcrowding. Overcrowding of hospitals EDs is an international problem, and one that has given rise to a number of policy and practice interventions. A commonly cited contributing factor is the impact of 'inappropriate' or non urgent patients on the ED capacity and management of patient flow. Suggestions have been made that this group could be identified and potentially re-directed or managed in other ways, thus reducing the burden on the ED workforce and resources. What is often overlooked, however, is the need to first identify what is meant by the term 'inappropriate'. Much of the research and recommendations currently available is based on the assumption that this definition is already known and agreed on. This thesis disputes that, and seeks to explore the degree of agreement possible within a group of expert NZ emergency care clinicians. Research Design: This study was positioned within a Mixed Methods approach utilising a consensus research technique, the Delphi process, to gather data. Consideration in choosing the research design was to identify a process that would maximise the opportunity to formulate a consensus definition or set of criteria which could potentially be applied to the practice setting. A three round Delphi survey was used, including rated statements, and free text responses. Thematic and simple descriptive statistical analysis was used in evaluating the findings from this study. Participants: An expert panel was established, consisting of 59 peer nominated clinical experts from ten tertiary level NZ EDs. This included 23 physicians and 36 nurses working in EDs with an average patient throughput of 30,000 or greater per annum. Results: Fifty nine individuals commenced the study, with 49 completing all three rounds of the Delphi, providing a retention rate of 84%. A NZ specific consensus (set at 70%) generated 18 conditions, which if the only cause for presentation in an otherwise well individual were found to be indicative of 'inappropriateness' for ED presentation. Agreement was not reached in regard to a sample international tool, or to a number of other conditions and situations presented in international studies. The NZ criteria were more specific than those suggested in the wider literature, and even where consensus was reached, there was evidence of 'outlier' opinions with strong viewpoints. The NZ experts asked for additional contextual information in relation to clinical assessment and eight additional non clinical factors were identified as impacting on decision making and assessment of appropriateness. Conclusion: Following application of a rigorous consensus process, limited agreement regarding appropriateness of patient presentations was reached by a NZ panel of expert clinicians. The NZ experts did not endorse the internationally derived definitions or criteria that were presented. There were several concerns expressed; including the ability to apply clinical criteria in the absence of social context, and how much relative weighting each of these aspects should receive. The essential subjectivity associated with some definitions was acknowledged and whether these could be applied prospectively was questioned. Recommendations were identified for clinical practice, policy development and further research. In particular, the importance of acknowledging existing assumptions, the need to question the evidential base for these, and the risks associated with failing to clarify the NZ perspective. 2012-09-28T02:29:44Z Prediction and Prevention of Complications in General Surgery Woodfield, John Campbell http://hdl.handle.net/10523/2468 2015-04-28T09:45:49Z 2012-09-27T23:53:48Z Prediction and Prevention of Complications in General Surgery 2012 Woodfield, John Campbell This thesis examines two concepts that impact on surgical complications – prediction and prevention. The starting point was a randomised controlled trial (RCT) which compared the frequency and the cost of infection for two prophylactic antibiotics. A parallel study also examined the surgeons' ability to predict wound infection and major complications. The results generated a number of important clinical questions, and it is the studies that were performed to investigate these questions which determined the direction and development of the thesis. Although prediction is fundamental to clinical practice, there was minimal objective data on the ability of the surgeon to predict complications. How good is the surgeon at predicting major complications? Can prediction be improved? How important is it when the surgeon changed the prediction of complications at the end of the procedure? This thesis addresses these questions. In contrast the ability of prophylactic antibiotics to prevent infection has been extensively studied and the theory behind their use is well understood. We wanted to assess the 'best prophylactic antibiotic' to use in abdominal surgery, both in terms of frequency of infection and cost effectiveness. We were also interested in the ability of the surgeon to predict wound infection and on the impact of prophylactic antibiotics on chest infection and urinary infection. The RCT comparing the use of ceftriaxone and cefotaxime showed that ceftriaxone had some advantages, including better prophylaxis for patients undergoing appendicectomy, and better prophylaxis against chest and/or urinary infection. This also demonstrated that the cost of infection was significantly different between the two antibiotics, and that this could be used to demonstrate significant differences in the severity of infection. For some endpoints there was a significant difference in the cost of infection even when the frequency of infection was the same. Differences in the frequency of chest infection and urinary infection were the impetus for performing a meta-analysis of all RCT assessing the prophylactic use of ceftriaxone. This showed that ceftriaxone was significantly better at preventing infection than other appropriately selected antibiotics. This difference was noted mainly in high risk cases. For the wound this was most noticeable after clean-contaminated and contaminated surgery. For chest infections this was after upper abdominal surgery and for urinary infections after pelvic surgery. The study looking at the prediction of wound infection, using a 100mm visual analogue scale (VAS), was performed immediately before and after surgery. This showed that the surgeon was poor at predicting who would, or would not, go on to develop a wound infection. However an increase in the prediction of infection postoperatively identified a high risk group of patients who developed significantly more infections. The finding that microbiological and surgical factors were only weakly predictive lead to a study which aimed to assess the importance of patient factors, as indicated by the American Society of Anesthesiologists (ASA) classification of physical status, on the development of wound infection. This demonstrated that in the context of optimal prophylactic antibiotic use that the impact of wound contamination was minimized and that host factors, as represented by ASA score, become more important in preventing wound infection. The prediction of major complications by the surgeon was then assessed in a three part prospective study. In part one prediction was made using a 100mm VAS immediately before and after surgery. In part two a preoperative multifactorial VAS, using six additional subscales was introduced. In part three predictions were completed following the presentation of detailed outcome feedback. Surgical prediction was initially 'as good as' the Physiology and Operative Severity Score for the enUmeration of Mortality and Morbidity (POSSUM) score. After the presentation of clinically relevant feedback there was an improvement in the prediction of major complications (from very good to excellent). This is the first time that feedback has been shown to improve the prediction of major complication. The prediction of major complications study also supported the following observations. Increasing the prediction of major complications postoperatively was important, and confirmed the importance of intraoperative events in determining the outcome of surgery. Surgical prediction was able to improve both the discrimination and goodness of fit of a multifactorial model for predicting complications. One reason for this is the ability of the surgeon to identify infrequent, but clinically important, risk factors. The prediction of complications by the surgeon using a VAS was accurate, versatile (when compared to a number of risk models), broadly applicable (able to be used by a number of surgeons and for a wide range of procedures) and adaptable. A major limitation is the need for formal reliability testing. When a VAS is intended to be used as a linear scale it is helpful to clearly label (or 'anchor') the VAS. Further studies need to look at the reliability and potential applications of surgical prediction of major complications using a VAS score. 2012-09-27T23:53:48Z


text:
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text:
* CAPTAIN JINKS. Lee & Walker. Philadelphia. [ca. 1868]
(Of The Horse Marines). Written & Sung By T. Maclagan. Lith: T. Sinclair. In. art.] Figure 5 in 5 pointed star. 8 pp., p. 2 blank, adv. on p. 8. Plate Mark 8711-5.
Illustration: Captain Jinks himself, in uniform consisting of a bearskin hat, green coat, red and white striped trousers, sword and beard.
* CAPTAIN JINKS. J. L. Peters. New York. 1868
Songs Of The Day. Figure 4 in circle. [n. lith. n. art.] [Arr. by W. D. Raphaelson .] 6 pp., pp. 2 and 6 blank. Plate Mark 4661-3.
Illustration: Front covers reproduced of four songs of this set: CHAMPAGNE CHARLIE, CAPTAIN JINKS, NOT FOR JOE, PRETTY LOUISE THE FLYING. TRAPEZE.
* CHAMPAGNE CHARLIE. Lee & Walker. Philadelphia. [ca. 1868] Comic Song Schottisch, followed by words of chorus. Each [Figure] 5 [in 5 pointed star]. Lith: T. Sinclair. 8 pp., p. 2 blank. adv. on p. 8. Plate Mark 9752-5.
Illustration: Charlie himself, in blue striped trousers, orange coat, blue "weskit," top hat, cigar in mouth, gloves, cane in right hand pointing to popping champagne bottle in left. Face adornment: "Dundrearys."
* LINGARD'S CAPT. JINKS. Oliver Ditson & Co. Boston. 1868
Of the Horse Marines. Figure 4 in circle. Lith: N. E. Lith. Stm. Ptg. Co. [n. art.] [6] pp., adv. on p. 2; p. 6 blank. Music Type.
Illustration: Lingard as Captain Jinks, sporting a riding crop over right shoulder.
* NOT FOR JOSEPH. C. H. Ditson & Co. New York. [ca. 1868]
Written Composed & Sung by Arthur Lloyd. Figure 5 in 6 pointed star. "Song" "Galop." Lith: John H. Bufford. N. Y. Underneath title: Comic Song. 6 pp., adv. on p. 2., p. 6 blank.
Illustration: Figure of man, probably Mr. Arthur Lloyd, gesturing with right hand, cane carried under left arm. Orange blazer jacket, tremendous Ascot tie, silk hat, etc.
J. L. Peters. New York. 1868
Songs of the Day. [Comic Song. Written by Harry Miller.] Figure 4 in circle. 6 pp., pp. 2 and 6 blank. Plate Mark 4631-3.
Illustration: Front covers reproduced of four songs. See CAPTAIN JINKS, published by J. L. Peters, above.


text: You are viewing Favorites - 2 of 91 1000 Pound Squat Fail By lolz There is nothing better in this world than accomplishing a feat as big as squatting... more »There is nothing better in this world than accomplishing a feat as big as squatting 1000 lbs. There is also nothing better than someone puking right after they do so. « less Published June 18, 2010 16k views More Info » Full Credits lolz Uploader Stats & Data 389 Funny Votes 390 Die Votes 16,024 Views Published: June 18, 2010 Categories: Sports Real Life Keywords: squat lift 1000 lb ton power lift power lifting strength power lifting power puke throw up chunks Up Next: Country Hip Hop Dancing AUTOPLAY Up Next In: 10 Country Hip Hop Dancing Visit Mexico! John C Reilly in Satisfaction Guaranteed Brostitute with Tim Roth Follow Facebook Twitter Tumblr Instagram Browse Related Comments Favorites 90+ more View All ▶ 2960+ more View All ▶ lolz Vaguely Related Videos Vaguely Related Pics & Words Advertisement Advertisement


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Former MP, Forest of Dean
Former MP for Forest of Dean
Entered the House of Commons on 17 November 1868 — General election
Left the House of Commons on 26 January 1911 — Died
Also represented Chelsea
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New Deviantart ID by SpcatsTashaWatch
©2013-2016 SpcatsTasha
Woah so deadly yet so sexy like a rose with thorns nice cosplay
That is so fucking awesome
Sorry for the swear but it needed it that's how cool a pic it is
Sorry for the swear but it needed it that's how cool a pic it is
One Word...... Oppai!!!!
where did your nipples go? :0
those two defy the laws of physics
i LOVING !
OMO~ yeoppo~
These are awesome, actually all your shots are awesome! you need them in Hi Res, and do some prints. I know, i'd buy some!
great series (for the model) you're so beautiful !!
Am i the only one curious as to where her nipple is sitting?
I don't think there are any. I think the breasts are actually a part of her costume that look like her skin.
Looks pretty real though!
Damn that hole
Great shot....
Just amazing and beautiful. Incredible Cosplay
So gorgeous! Love everything!
These suits are sultry, you look awesome
omg you look amazing! Awesome work :3


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