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A Rabbi's World
The JW Q&A
Tim Boxer
Culture View
A Rabbi's World
A Rabbi's World
Culture View
Tim Boxer
The JW Q&A
On Sunday, June 2, the 50th Celebrate Israel Parade (formerly the Salute to Israel Parade) will march up Fifth Avenue from 57th Street to 74th Street, from 11 a.m. to 4 p.m., rain or shine. The theme is "Picture Israel: The Art & Craft." The parade will be broadcast on WOR Channel 9, noon-2 p.m. and JL-TV from 2-3 p.m. The Jewish Week recently spoke to the parade's director, Michael Mittelman.
Q: In New York the parade sometimes seems more of a holiday than even Yom Ha'Atzmaut [Israeli Independence Day], a respite from tough talk and tough love; just love. What's new to love about the parade this year?
A: It's an unparalleled day of celebrating Israel. This year all the artwork, the posters, the street banners are by Peter Max. We'll have 31 floats, more than last year; more than 200 groups, total. Players from the Israeli soccer team (who'll be playing Honduras later that afternoon at Citi Field) will be on a float. Gilad Segev, the Israeli artist, is coming from Israel. Soulfarm will be here. Tel Aviv DJ Eric Voz will be performing.
Sometimes the many day schools, with their mandatory school attendance, faculty supervision and marching principals in themed T-shirts, give the parade the air of a school assembly, albeit a colorful and happy one. Why can't the Israel parade have the non-mandatory, spontaneous exuberance of, say, the West Indian or Puerto Rican parade? Other ethnic groups draw more spectators and don't rely on marching children and the parents who wave to them.
It is school-oriented. Obviously the day schools make up the backbone of the parade, and we're thrilled they come out. Look, we've had 49 years of this parade's history, and it's been successful. We've tried to add marching bands and street performers, putting it on TV, adding Israeli talent. I think we've done a great job of making it more attractive to people. We have people from the Russian community, the Persian community, the Syrian community. We always encourage and try to get new groups out, and we have a great showing of people who attend every year. We were just named by Crain's as the 14th largest outdoor festival in New York.
Has the parade been able to broaden the base of the marchers and spectators?
We've been very successful in bringing in more than 75 new synagogues from across the denominations. And nonprofits also. Last year, Moishe House came as spectators; this year they're marching. We want this parade to reflect the diversity of our community.
Have there been any issues of exclusion, such as with gays or BDS (boycott, divestment and sanctions) groups marching? (Until 2012, LGBT groups were not allowed to march openly in the parade.
We're aware of no issues. Gay groups are marching, and no groups who espouse BDS have approached us to march in the parade.
Is J Street [the "pro-Israel, pro-peace" lobby] marching?
We don't allow political groups, and that goes for AIPAC [American Israel Public Affairs Committee], too.
Is there any conflict with the explicitly political Israel Day Concert in Central Park, adjacent to the parade?
There's no conflict but we're not connected to it. (The concert is sponsored by the National Council of Young Israel).
There have been complaints that the Fifth Avenue route is too far from kosher food, affordable parking, subways or bathrooms. Next year is the 50th anniversary of the original Israel parade in 1964 on Riverside Drive, a beautiful route in a more densely populated Jewish neighborhood where more people could walk to the parade, with easier access to everything Fifth Avenue lacks. Has there been talk of a 50th anniversary return to the parade's roots on Riverside Drive?
A lot of it is dependent on the city and the permit process. We have this permit, this history of being here successfully. And it's very pretty next to the park. The park is close to where the Celebrate Israel Run [beginning at 8 a.m.] ends up, so we're convenient for people who go to the run who then want to stick around for the parade. It's important to highlight that June 2 will be a whole day of events," from the run to the parade to the Israel-Honduras soccer game.
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It is absolutely untrue that there has been no controversy over the inclusion of openly gay groups. As reported in the Forward a couple of weeks ago, I have been conducting a campaign since last year's parade to encourage Orthodox groups to withdraw from the parade. For Michael Mittelman to insist that he is "aware of no issues" regarding this matter is disingenuous, to say the least. If he is directing the parade, then he is certainly aware that Jewish Community Relations Council head Michael Miller was summoned to a meeting of Jewish principals in March. Grave concern over the inclusion of openly gay groups was conveyed to Miller. And about two weeks ago, the parade was warned by a leading yeshiva principal that Jewish Queer Youth had better desist from displaying the offensive banners that they carried last year.
In truth, Orthodox groups are very disturbed by the inclusion of openly gay groups. The only question has been whether to threaten a boycott or whether to march despite having severe reservations.
I'm looking forward to being a part of the "Salute to Israel" parade with my synagogue.This will be my first time!


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Parental Guidance (2012) International Trailer B
International trailer for Parental Guidance.
Old school grandfather Artie (Billy Crystal), who is accustomed to calling the shots, meets his match when he and his eager-to-please wife Diane (Bette Midler) agree to babysit their three grandkids when their type-A helicopter parents (Marisa Tomei, Tom Everett Scott) go away for work. But when 21st century problems collide with Artie and Diane's old school methods of tough rules, lots of love and old-fashioned games, it's learning to bend - and not holding your ground - that binds a family together.
Film Info
1 min 46 sec Duration
4,317 views
- Posted: November 05, 2012
- Director: Andy Fickman
- Writer: Joe Syracuse
- Studio: 20th Century Fox
- Release: December 25, 2012
- Cast: Billy Crystal, Bette Midler, Marisa Tomei
Trailer Tracks
No music available

subset: commoncrawl


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Local delegation appeals for state to clarify gambling laws
Published: Saturday, January 8, 2011 at 6:30 a.m.
Last Modified: Sunday, January 9, 2011 at 12:18 a.m.
The groups that make an annual appeal to Marion County's legislative delegation usually tend to have a common message: Send financial help, but if not, then don't hurt us.
This year, however, state lawmakers who represent Marion County heard two appeals for opportunities to make — and not take — money.
Some residents want lawmakers to clarify state gaming laws that pertain to instant bingo and Internet cafes — requests whose responses might preview a bigger battle brewing in Tallahassee over gambling.
Benny Bachand, executive director of the Veterans of Foreign Wars' Florida state department, which is headquartered in Ocala, told the panel last week that nonprofits such as the VFW need help in raising money through gaming.
Specifically, he discussed instant bingo and the group's efforts to have that permitted through vending machines.
Bachand told lawmakers that the VFW's desire has been stymied by an opinion rendered by former state Attorney General Bill McCollum.
In that July 2008 opinion, requested by the Pasco County sheriff, McCollum noted that state lawmakers had long ago carved bingo out of Florida's anti-gambling laws, granting nonprofits and veterans groups some legal latitude in the process.
In 2007, McCollum wrote, the Legislature updated that to include instant bingo, whereby players are issued a peel-off ticket.
But allowing them to buy those tickets through a machine was a no-no, McCollum added.
Such devices equated to a "slot machine" and their operation, even for instant bingo, amounted to an illegal lottery, McCollum concluded.
Bachand told local lawmakers that the VFW tried several times to get McCollum to rescind the opinion, but he declined.
The result of that lobbying was two bills, filed last year in both the state Senate and House of Representatives, that would have permitted automated sales of instant bingo tickets. One of those measures was submitted by state Sen. Charlie Dean, R-Inverness, whose district spans much of western Marion.
Both died in committee.
"We're not trying to expand gambling," Bachand told the local delegation. "We're just trying to expand the opportunity that nonprofits can make so that the money they derive goes back into the community" through services provided to veterans, children and other community needs.
"Obviously, in these economic times," he added, "our posts need more opportunities."
In response, Dean said he would welcome the VFW back for another try.
"Sometimes you don't get over the mountain, you try another side of the mountain, and you climb up again," Dean said. Dean said there were now a new administrators in Tallahassee that "have a different way of thinking."
Yet state Rep. Charles Van Zant, a Keystone Heights Republican whose district includes northeast Marion, offered a rebuttal.
Van Zant said he opposes gambling and would vote against any bill to further it.
"I believe it's a detriment to our society," said Van Zant. "We need to do away with gambling and control gambling as much as possible."
That would include, he added, ridding Florida of the state-run lottery and opting to fund public education, the beneficiary of lottery proceeds, through general tax revenues.
Van Zant, also a staunch opponent of new or increased taxes, said the only caveat to his stance would be to restrict gambling to casino and race tracks and taxing it heavily.
"I believe it is an evil and does need to be taxed," he said.
Internet cafes
In a different vein, Glenn Lane, a commercial Realtor from Ocala, asked the Legislature to try to define laws regarding Internet or "sweepstakes" cafes — which have been targeted for prosecution locally.
Lane told the delegation that he had harbored a preconceived notion of the cafes' clientele and had been "reticent" to rent his property to such businesses.
But his opinion disintegrated once he finally visited one that opened near him.
Once inside, he said, he found the same well-groomed, well-mannered customers that you might find in any local restaurant, pursuing their interest in a setting that "was as quiet as any of our libraries."
Lane recalled that some owners of these outlets had been arrested for running illegal gambling operations.
Those efforts had failed, he noted.
The Star-Banner reported last month that prosecutors had dropped the charges against two men accused of violating state anti-gambling laws by running an Internet cafe.
Typically, customers at such establishments purchase time on the Internet that could be used for surfing the Web or checking e-mail.
Yet clients also purchase credits that could be utilized to play online games, including sweepstakes. If the patron wins the sweepstakes games, they are usually paid in cash.
Local prosecutors argued this amounted to using computer terminals as illegal slot machines. But they have had a hard time convincing judges and jurors of that.
Last month's abandonment of the case against Jeffrey Reed and John R. Andrews, owner and manager, respectively, of the Cyber Zone E-Café on Southeast Maricamp Road, came a year after Circuit Judge Hale Stancil had thrown out the state's first case against Reed on charges of keeping a gambling house, conducting a lottery and possessing coin-operated devices.
Three months ago, a jury acquitted Jeaneen Crisante of gambling charges related to her business, Marion Internet Services in Summerfield.
In the wake of those defeats, prosecutors have said they need "clarification" from state lawmakers about the operation of Internet cafes.
Lane, the Realtor, said Thursday that now that prosecutors had apparently backed off, cafe operators were showing interest in renting from him. But he wasn't sure how to proceed since the laws appeared muddled.
"I'd recommend you stay away from that," Van Zant said.
State Sen. Evelyn Lynn, R-Ormond Beach, who represents eastern Marion, said the Attorney General's Office might revisit the issue but that it was questionable about what changes could be made. She urged Lane to write to new Attorney General Pam Bondi.
State Rep. Dennis Baxley, R-Ocala, another gambling opponent, did not comment on either issue.
Yet he might have considerable influence over the debate as it continues this spring.
House Speaker Dean Cannon, R-Winter Park, has tapped Baxley to serve as chairman of the House Criminal Justice Subcommittee.
In an interview Friday, Bachand, of the VFW, said aside from the bingo games, the Legislature must get involved in the matter because gaming companies have software offering sweepstakes games that comply with state law and the public needs to know that. "They ought to define what these things are, whether it's for a nonprofit or a for-profit, so people can run them without the fear of being shut down," he said.
Statewide implications
The gambling issue appears ready to draw considerable attention as cash-strapped elected leaders debate how to plug a multibillion-dollar hole in the state budget.
On Friday, the St. Petersburg Times reported that Gov. Rick Scott was ready to step back from his anti-expansion stance to consider a plan that might bring as many as five new ritzy casinos to South Florida, Tampa and other parts of the state.
State Sen. Dennis Jones, R-Seminole, was also working on legislation to facilitate that and to create a gambling commission to regulate the venues, the paper reported.
Baxley, in the Times report, said proponents of such a plan were acting out of "desperation" in relying on "gambling addicts" to help address the budget shortfall.
In a news conference Friday, the new governor denied flip-flopping on gambling. "I've not taken any position I want to expand gaming or make any changes," he said, according to The Associated Press.
Contact Bill Thompson at 867-4117.
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jasonluckydog, 23 Jan 2010
Posted 23 Jan 2010
He better hope a good gust of wind doesn't get under that hat, or it'll beat the living daylights out of him!
Poor guy.....I mean one drop of bird sh!t would pound him in the ground.
Must be left handed.
Jeremy Igo
Started 11 hours ago
Started 4 minutes ago


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This is what the Liberals have brought us to. Allowing a crazy freak Liberal from a communist country to manipulate our elections to better suit his need for greed. He set America up for Ruler Obama knowing this Boob would fail… thus earning him billions of dollars… And it only cost him about $50 million to pull it off. Congratulations you Libtards.
I hope George Soros contracts a prolonged and painful illness, one which brings him 20 miserable years of excruciating pain and suffering. God knows he deserves it.
The Obama/Soros Plan To Destroy America. How do we stop George Soros and Obama?
danaslc 2010/01/16 14:52:25
OBAMA'S MAIN 'PUPPETEER' IS THE HUNGARIAN BORN JEW – GEORGE SOROS. With his financial ability in the billions of dollars to back whatever cause he chooses and his powerful control of the media, Soros has the means to engineer the political and economic destinies of entire nations. Indeed, Soros has already implemented his global agenda in both Georgia and Kosovo.
The latest "cause" backed by Soros is the Obama presidency. Known as Obama's "money man," Soros's involvement with Obama's national political career began in 2005 with Soros fundraising for Obama's campaign for US Senate and continued through the 2007 Presidential campaign launch with huge fundraising operations managed by Soros.
Soros, a proponent of the "hard left," has also been funneling money into the Democratic Party and to its candidates with the intent on building a slate of Senators and Representatives with socialist leanings. "George Soros has purchased the Democratic Party," said Republican National Committee spokeswoman, Christine Iverson, "and he who pays the piper calls the tune."
Through his Open Society Institute, Soros has contributed to left wing socialist groups such as, Human Rights Watch, Jewish Council for Public Affairs, The New American Foundation, ACORN, MoveOn, and his own, Center For American Progress, of which, Obama recently appointed its senior fellow, Todd Stern, as his 'Climate Czar.' Stern, a Zionist Jew, is the chief architect of the socialist-inspired Climate Change Bill, just passed by Congress.
George Soros now has a superhighway to Change – 'Socialist Change.' We are already beginning to see the largest growth in government in the history of America. Hell-bent on destroying the American dollar and installing a global currency, Soros has got his bought-and-paid-for White House stooge now installing his socialist agenda.
FOR IN HIS FIRST 100 DAYS as president, Obama has passed a flurry of deficit-deepening legislations such as the Stimulus Bill, the Equal Pay Bill, the Global Poverty Bill, the Tobacco Bill, the Climate Change Bill, and his upcoming Health Reform Bill. These will bring an already bankrupt America into a deficit of $2 trillion dollars including interest on the debt, paid to the Zionist Jews who own the Federal Reserve Bank. Obama's next plan is to pass a UN sponsored Bill which will force Americans to pay a global tax. View Entire Story Here & Here.
And who will be the ruling elite of the socialist American state now in the making? Wealthy and powerful Jews – like George Soros – who have eliminated all capitalist power blocs that would oppose them. And with Obama's creeping socialism becoming more and more apparent, George Soros emerges as the chief mogul behind Obama's Marxist policies.
OBAMA'S CHILDHOOD MENTOR WAS THE MARXIST, Frank Marshall Davis, a black communist writer.
In his book, Dreams From My Father, Obama admits developing a close relationship, "almost like a son," with Davis in 1977, whom he repeatedly refers to as "Frank." Writing about attending "socialist conferences" and coming into contact with Marxist literature, Obama reminisces of listening to Frank's "poetry" and getting advice on his career path.
One particular piece of Marxist literature, Rules for Radicals, penned by the Chicago Marxist Jew, Saul Alinsky, had oft been quoted by Obama in campaign speeches during his run for a State Senate seat in Illinois in 1996.
Obama's embrace of the ideology of Saul Alinsky began when he was 24 years old, unmarried, very accustomed to a vagabond existence, and according to his memoirs, Dreams From My Father, was searching for a genuine African-American community.
White leftists of the Developing Communities Project of Chicago were looking for someone who could recruit in a black neighborhood in the south side of Chicago. Obama answered their Help-Wanted ad and soon took up a paid position as a community organizer. The Developing Communities Project was built on the Alinsky model of community agitation, wherein paid organizers learned how to "rub raw the sores of discontent."
"The agitator's job," according to Alinsky, "is first to bring folks to the realization that they are indeed miserable, that their misery is the fault of unresponsive governments and greedy corporations, then help them to bond together to demand what they think they deserve."
As a confirmed atheist, Alinsky saw an opportunity to cynically spread his socialist ideology in already-formed church communities as being the perfect springboards for agitation and creating bonds for their demands.
WHEN OBAMA FIRST UNDERTOOK HIS AGITATION WORK, he was un-churched. But to fulfill the Alinsky manifesto, Obama joined a huge black nationalist church, whose pastor, Reverend Jeremiah Wright, (whom Obama called his spiritual mentor), preached a "black" gospel. Denouncing white supremacy and decrying black inferiority, Wright would intone from the pulpit: "GAWD! Has GOT! To be SICK! OF THIS S**T!" View Entire Story Here & Here.
In 1996, Obama received the endorsement of the Chicago branch of the Democratic Socialists of America (DSA) for an Illinois State Senate seat. Later, the Chicago DSA newsletter reported that Obama, as a State Senator, showed up to eulogize the Jew, Saul Mendelson, one of the "champions" of "Chicago's democratic left."
The Democratic Socialists of America is the principal US affiliate of the Socialist International, which enjoys a "consultative status" with the United Nations. This international connection is significant because two of Obama's recent legislations, The Global Poverty Act, and The Climate Change Bill, are both pieces of the UN's socialist agenda to siphon the wealth of Western nations to Third World Muslim countries and ultimately, to implement its plan for a socialist World Government.
SOROS WAS BORN OF JEWISH PARENTS IN BUDAPEST IN 1930 as Gyorgy Schwartz. When young Gyorgy Schwartz enrolled at the Fabian socialist London School of Economics in 1949 he changed his surname to Soros. At the London School of Economics he became friends with Marxist philosopher Sir Karl Popper, founder of the Association of Socialist School Students and author of the 1945 book, The Open Society And Its Enemies.
In 1956, in an "open society" of America, of which Soros now wishes to expand into a "borderless society," young George Soros arrived on Wall Street with $5,000 and quickly demonstrated a Jewish "knack" for investing other people's money.
Soros soon came to be called "the greatest money manager in the world" by satisfied clients of his multi-billionaire international hedge fund called the Quantum Fund. Today, Forbes Magazine ranks him the 28th richest person in the United States, with an estimated fortune worth $7 billion.
In 1993, Soros established the US branch of his Open Society Institute as a "tax-free" foundation to support his socialist foundations in Central and Eastern Europe. The President of the Open Society Institute is the Jew, Aryeh Neier, who as Director of the Socialist League For Industrial Democracy, personally created the radical group Students For A Democratic Society in 1959.
Though he likes to be considered a "stateless statesman," Soros, in fact, is more accurately described as the "Godfather of World Socialism." For through his Open Society Institute, Soros funds an army of socialist organizations that advocate abortion, open borders, amnesty for illegal aliens, a global currency, prevention of global warming, and a world poverty tax. View Entire Story Here.
Again, two of Obama's recent legislations, The Global Poverty Act, and The Climate Change Bill, are both pieces which are consonant with the George Soros agenda.
OBAMA'S SOCIALIST CONNECTIONS EXPLAINS WHY he has libertine views on sexual matters such as abortion and homosexuality.
One of Obama's first actions in office was to issue an executive order authorizing federal funds for pro-abortion groups that operate globally. Obama supports the Freedom of Choice Act, which would make abortion an entitlement that the government could not limit.
This falls in line with the socialist agenda of George Soros, the "puppeteer" pulling the strings of his "puppet," Barack Obama. Among Soros's demands are to make abortions freely available and to legalize gay marriages. Soros also demands full rights for illegal aliens and felons, as well as the legalization of euthanasia for the "infirm." And, oh yes, Soros demands the end of US global supremacy through a borderless society.
Unless we wake up soon, our "infirm" nation will soon be put to an eternal sleep by Barack Obama & George Soros, The enitire article is at this link.
Top Opinion
Lisa 2010/01/16 15:56:47 (edited)
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- ProtestTheLeft 2011/11/01 19:53:02We should be very picky about where we spend our money, and stop funding the left. How on earth do we stop Soro's? Surely he is not untouchable, he must have an Achilles heal of some sort. Find his weak spot and exploit it for all it's worth! The time for sitting idly by why these radicals take our nation straight to Hell has ended! The time decisive action is now! American, break out of your stupid addiction of having to be entertained all the time, and be careful of where you dine out at. Follow the money trail of George Soros to the end, and cut it off! Use you money to work against his agenda, instead of filling your own belly with cheeseburgers, taco's, and pizza! I think Americans are too lazy, and apathetic to take any real action. Therefore we are witnessing the beginning of Communist uprising that will eventually end our freedom, and liberty. Then it won't be long till those of us that do not agree are marched into the gas chambers.
- betty85260 2010/02/08 01:10:26
- aebe 2010/02/02 07:07:12+1Soros,no matter any other label,is an anarchist,with the goal of destroying western civilization. This I believe,because it is impossible for the U.N.,or any form of world government to function;there is no means of controlling corruption,and,who will decide who is first in receiving any asset ? The O'Bummer might believe that he will be President of the World,but his would simply be the first in an unending string of assassinations.
Palin/Bachmann '12 !
Veterans - We,and the women and men now serving have EARNED our 2nd Amendment Rights.Why should we allow any corrupt politician to deny that ?
- nightlight 2010/01/17 01:06:46
- granny1944 2010/01/16 23:53:50get rush limpbog and pat rollbesome real racist into office that will stop all this mess
- Edward 2010/01/16 23:44:12
- texasred 2010/01/16 23:04:31
- Ladnar 2010/01/16 23:00:06
- Ken OLD CRA... 2010/01/16 22:01:31I agree - I mean, so WHAT that he was voted in by the majority of people who agreed with his policies. I say if we (a minority) can hijack the democratic process to force our own issues down the throat of this country lets DO it. So WHAT that we can't do it by having our party's officials win positions simply because they're too polarized for the majority of people in this country. we are RIGHT!
- Ah... yes... that 'silent' majority. LOL....
- You seem to be a complete moron too spoiled by Americas status as having the best living standard in the world to comprehend that everything you stand for contradicts your own existence.
- The Sane One 2010/01/16 20:32:50
- How about Soros?
- The San... danaslc 2010/01/19 18:35:08I think that you posted a pretty good article about Soros... I was just wondering if you would do the same for the other side of the coin.
If not, I'll understand.
- Edgar The San... 2010/01/26 07:26:15Why cant you stay on topic? If you want to discuss Koch start your own blog. Simple as that-
- The San... Edgar 2010/01/26 18:14:58I was just trying to see if this would be an objective discussion topic, or simply yet another one-sided rant.
You answered my question more than adequately.
- Edgar The San... 2010/01/26 18:23:29Oh you are such a victim and I feel so sorry for you!LOL So why dont you start a Koch blog and then I can post how much you should really be talking about Soros?LOL And then when you want to stick to one topic-the Koch topic- I will blame you for creating a one-sided rant with no objectivity. Geez your logic is so pathetic.
- sparta 2010/01/16 20:18:39
- Ken 2010/01/16 19:53:11
- +3This started with Clinton, then Bush and now Obama. Soros just thinks that Obama can move faster because of his color and they now have enough illegals in this country that they can take over. YES TAKE OVER! If you have not noticed the illegals have hijacked our country with the help of Clinton, Bush and Obama.
Three amigo's and Soros as their head man.
- I hear you!!
- Money money money and power power power will cause you to throw away your God.
- I'm for that!
- Hazel 2010/01/16 19:43:00
- TopShelf® (oyo) 2010/01/16 19:11:22
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Publications (21)63.28 Total impact
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ABSTRACT: Background: The present study aimed to obtain information enabling optimisation of the clinical effect of mizoribine (MZR) in pediatric patients with kidney disease. Methods: A total of 105 pediatric patients with kidney disease treated at our institutions were enrolled. Kidney transplant patients were excluded. Population pharmacokinetic analysis of MZR was performed based on serum concentration data. Area under the curve from time zero to infinity (AUC∞) and maximal concentration (C max) were calculated by Bayesian analysis. Results: In children, the appearance of MZR in the blood tended to be slower and the subsequent rise in blood concentration tended to be more sluggish, compared to healthy adults. Apparent volume of distribution and oral clearance were also higher in children compared to adults. A significant positive correlation was observed between patient age and AUC∞. There were significant differences of AUC∞ and C max by age group. No relationship was observed between the administration method of MZR and serum concentration. Conclusion: The pharmacokinetics of MZR was different in children compared to adults. To obtain the expected clinical efficacy, the regular MZR dosage schedule (2-3 mg/kg/day) might be insufficient for pediatric patients. In particular, younger patients might require a higher dosage of MZR per unit body weight.
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ABSTRACT: End-stage renal disease (ESRD) in children is considered a rare, but serious condition. Epidemiological and demographic information on pediatric ESRD patients around the world is important to better understand this disease and to improve patient care. The Japanese Society for Pediatric Nephrology (JSPN) reported epidemiological and demographic data in 1998. Since then, however, there has been no nationwide survey on Japanese children with ESRD. The JSPN conducted a cross-sectional nationwide survey in 2012 to update information on the incidence, primary renal disease, initial treatment modalities, and survival in pediatric Japanese patients with ESRD aged less than 20 years during the period 2006-2011. The average incidence of ESRD was 4.0 per million age-related population. Congenital anomalies of the kidney and urinary tract were the most common cause of ESRD, present in 39.8 % of these patients. In addition, 12.2 % had focal segmental glomerulosclerosis and 5.9 % had glomerulonephritis. Initial treatment modalities in patients who commenced renal replacement therapy (RRT) consisted of peritoneal dialysis, hemodialysis, and pre-emptive transplantation (Tx) in 61.7, 16.0, and 22.3 %, respectively. The Japanese RRT mortality rate was 18.2 deaths per 1000 person-years of observation. The incidence of ESRD is lower in Japanese children than in children of other high-income countries. Since 1998, notably, there has been a marked increase in pre-emptive Tx as an initial treatment modality for Japanese children with ESRD.
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ABSTRACT: Our understanding of inherited salt-losing tubulopathies has improved with recent advances in molecular genetics. However, the terminology of Bartter syndrome and Gitelman syndrome does not always accurately reflect their pathophysiological basis or clinical presentation, and some patients are difficult to diagnose from their clinical presentations. In the present study, we conducted molecular analysis and diuretic tests for patients with inherited salt-losing tubulopathies to clarify the pharmacological characteristics of these disorders. We detected mutations and subsequently conducted diuretic tests using furosemide and thiazide for 16 patients with salt-losing tubulopathies (two with SLC12A1; two with KCNJ1; nine with CLCNKB; and three with SLC12A3). Patients with SLC12A1 mutations showed no response to furosemide, whereas those with SLC12A3 mutations showed no response to thiazide. However, patients with CLCNKB mutations showed no response to thiazide and a normal response to furosemide, and those with KCNJ1 mutations showed a good response to both diuretics. This study revealed the following characteristics of these disorders: 1) subjects with CLCNKB mutations showed one or more biochemical features of Gitelman syndrome (including hypomagnesemia, hypocalciuria, and fractional chloride excretion insensitivity to thiazide administration); and 2) subjects with KCNJ1 mutations appeared to show normal fractional chloride excretion sensitivity to furosemide and thiazide administration. These results indicate that these disorders are difficult to distinguish in some patients, even when using diuretic challenge. This clinical report provides important findings that can improve our understanding of inherited salt-losing tubulopathies and renal tubular physiology.
Article: Evaluation of Limited Sampling Designs to Estimate Maximal Concentration and Area under the Curve of Mizoribine in Pediatric Patients with Renal Disease[Show abstract] [Hide abstract]
ABSTRACT: The aim of this study was to evaluate limited sampling designs to estimate the maximal concentration (C(max)) and area under the curve (AUC) of mizoribine in pediatric patients with renal disease. We utilized 48 serum mizoribine concentration profiles obtained from the full (6-point) sampling pharmacokinetic test, and estimated 48 individual C(max) and AUC values accurately with Bayesian analysis using the full sampling data. We then developed limited sampling models (LSM) for C(max) and AUC using 1-4 serum mizoribine concentration data points. The C(max) and AUC estimation performance of the Bayesian and LSM analysis was fairly good in the 3-point (2, 3, and 6 hr after the dose) sampling design. In addition, the C(max) estimation performance of the Bayesian and LSM analysis deteriorated only marginally even in the 1-point (3 hr) sampling design. On the other hand, the AUC estimation performance seemed to be inadequate in the 1-point (3 hr) sampling design; however, it improved markedly in the 2-point (3 and 6 hr) sampling design. These findings suggested that the 1-point (3 hr) sampling design is promising for approximate C(max) estimation, but that the 2-point (3 and 6 hr) sampling design is preferable to estimate the AUC of mizoribine.
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ABSTRACT: Background and Methods. The NPHS1gene was analysed in different five Japanese patients with congenital nephrotic syndrome (CNS) from the patients in a previous report (Sako M, Nakanishi K, Obana M et al. Analysis of NPHS1, NPHS2, ACTN4, and WT1 in Japanese patients with congenital nephrotic syndrome. Kidney Int 2005; 67: 1248–1255) that suggested that the mutation of NPHS1 was not a major cause of CNS in Japanese patients. Genomic DNA was extracted from leukocytes, and all exons and exon–intron boundaries were analysed for NPHS1 using polymerase chain reaction and direct sequencing. Results and Conclusions. Compound heterozygous mutations of NPHS1 were found in four patients and homozygous mutations in one patient. Interestingly, three patients out of five had the same mutation in NPHS1: nt2515(delC). Parents who had this mutation heterozygously were from neighbouring prefectures. Two among five patients in this research and one in the previous report (Kidney Int 2005; 67:1248–1255) had the same mutation: 736G > T in exon 7. All mutations including these two mutations except for one have never been reported outside of Japan yet.
Article: Risk factors for neurological complications in complete hemolytic uremic syndrome caused by Escherichia coli O157[Show abstract] [Hide abstract]
ABSTRACT: The aim of the present study was to investigate the predictive parameters for encephalopathy in complete hemolytic uremic syndrome (HUS) in a large outbreak of O157: H7 infection in 1996. A total of 182 inpatients, 71 of whom had complete HUS, including 12 patients with neurological complications, and 46 colitis patients were studied. Presenting signs and symptoms (n = 115) and laboratory data (n = 69) were analyzed using monovariate and multivariate analysis. After adjusting for age and gender, logistic regression showed that presenting symptoms such as bloody diarrhea (odds ratio [OR] = 7.39), proteinuria (OR = 6.16), hematuria (OR = 8.31), oliguria (OR = 17.4) and a pale face (OR = 10.7) were useful for predicting complete HUS. Also, increased white blood cell counts >12,000 microL/mL (OR = 10.0) and C-reactive protein >1.5 mg/dL (OR = 7.39) at the onset of infection, were useful as predictive laboratory parameters. To predict neurological complications in complete HUS patients, the average daily increase of lactate dehydrase >1200 IU/L per day (OR = 26.3) and creatinine >0.5 mg/dL per day (OR = 12) were found to be useful on multivariate logistic regression. There are useful predictive clinical factors for neurological complications in complete HUS.
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ABSTRACT: McCune-Albright syndrome is characterized by café-au-lait spot, multiple endocrine hyperfunction, and polyostotic fibrous dysplasia. A somatic point mutation of Gsalpha protein leads to an increase in the Gsalpha-associated hormone activity in McCune-Albright syndrome. Because cyclic adenosine 3',5'-monophosphate stimulates the dopamine beta hydroxylase gene, an activating mutation of the Gsalpha protein may cause the hyperproduction of norepinephrine via dopamine. We report on a 9-year-old girl with McCune-Albright syndrome complicated by severe arterial hypertension. The urinary excretion of norepinephrine was 5- to 10-fold higher than in age-matched controls. Meta-iodobenzylguanidine scintigraphy and positron emission tomography/computed tomography (PET/CT) revealed no hot spots. These findings suggest that severe hypertension might be due to an activating mutation of Gsalpha protein in sympathetic ganglia. Because of the reported association of GNAS1 gene polymorphism with hypertension, our patient provides further evidence for a role of Gsalpha protein in hypertension.
Article: Risk factors for developing severe clinical course in HUS patients: A national survey in Japan[Show abstract] [Hide abstract]
ABSTRACT: Hemolytic uremic syndrome (HUS) is characterized by acute renal failure, thrombocytopenia and hemolytic anemia. Cases accompanied by prodromal gastrointestinal tract symptoms are referred to as typical HUS. Some severe HUS patients require dialysis or develop central nervous system (CNS) disorders after the onset of HUS. Patients who developed typical HUS in 2001 and 2002 in Japan, 127 in all, were the study subjects. To identify the risk factors for the development of a severe clinical course, clinical and laboratory data were analyzed on logistic regression. Two of the 127 patients died (1.6%): one from acute cardiac failure and the other from a CNS disorder. Thirty-five patients required dialysis (28%) and 30 had CNS symptoms (24%). Multivariate analysis indicated that the risk factors for need for dialysis were serum sodium and alanine aminotransferase (ALT) levels of </=130 mEq/L and >/=70 IU/L, respectively, at the onset of HUS and those for developing CNS disorders were dialysis and C-reactive protein (CRP) >/=5.0 mg/dL at the onset of HUS. Because patients with these risk factors, such as low serum sodium, high ALT or high CRP levels, may require dialysis or develop CNS disorders, they should be treated carefully in the early stage of HUS.
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ABSTRACT: Renal tubular dysgenesis is a critical disorder characterized by the Potter phenotype and severe hypotension in the early neonatal period. We herein report a 3-year-old female with renal tubular dysgenesis. Endocrinological studies showed a high plasma renin activity (over 49.2 ng/ml/h; normal range 2.0-15.2), high active renin concentration (1,823.5 pg/ml; normal range 2.4-21.9), and low angiotensin-converting enzyme (ACE) concentration (1.7 U/l; normal range 8.3-21.4). Taken together, these findings suggested an abnormality of the ACE gene, ACE. Direct sequencing analysis revealed two novel deletions in the coding region of ACE. We conclude that hormonal analysis of the renin-angiotensin system can aid in identifying the responsible genes and help with efficient gene analysis and pathophysiological considerations.
Article: Molecular Analysis of Patients With Type III Bartter Syndrome: Picking Up Large Heterozygous Deletions With Semiquantitative PCR[Show abstract] [Hide abstract]
ABSTRACT: Type III Bartter syndrome (BS) (OMIM607364) is caused by mutations in the basolateral chloride channel CIC-Kb gene (CLCNKB). The CLCNKB gene is sometimes reported as having a large deletion mutation, but all cases reported previously were large homozygous deletions and a large heterozygous deletion is impossible to detect by direct sequencing. This report concerns a genetic analysis of five Japanese patients with type III BS. To identify the mutations, we used polymerase chain reaction (PCR) and direct sequencing. To detect large heterozygous deletion mutations of the CLCNKB gene, we conducted semiquantitative PCR amplification using capillary electrophoresis. The result was that four mutations were identified, comprising one novel 2-bp deletion mutation, an entire heterozygous deletion, and a heterozygous deletion mutation of exons 1 and 2. The nonsense mutation W610X was detected in all patients, and this mutation is likely to constitute a founder effect in Japan. Capillary electrophoresis is a new method and extremely useful for detecting large heterozygous deletions, and should be used to examine type III BS cases in whom only a heterozygous mutation has been detected by direct sequencing. This is the first report to identify large heterozygous deletion mutations in the CLCNKB gene in patients with type III BS.
Article: EYA1 and SIX1 gene mutations in Japanese patients with branchio-oto-renal (BOR) syndrome and related conditions[Show abstract] [Hide abstract]
ABSTRACT: We isolated genomic DNA from 15 patients with branchio-oto-renal (BOR) syndrome or BOR-related conditions. Seven patients had BOR syndrome (two familial and five sporadic), and eight had deafness and renal malformations without branchial fistula (BOR-related conditions). We analyzed all exons and exon-intron boundaries of EYA1 and SIX1 using the polymerase chain reaction (PCR) direct sequencing, and characterized their mutations. In some patients, analysis of mRNA by reverse transcription (RT)-PCR was performed to examine whether the mutation affects the mRNA splicing. We identified five novel disease-causing heterozygous EYA1 mutations in five patients with BOR syndrome (two familial and three sporadic, 5/7=71%), but EYA1 and SIX1 mutations were not detected in the other two patients with BOR syndrome or any of the patients with BOR-related conditions. The detected EYA1 mutations were two nonsense mutations, two splicing acceptor-site mutations, and a point mutation (G>T) of the first base of exon 10. Analysis of mRNA by RT-PCR direct sequencing revealed that the latter point mutation led to the skipping of exon 10. In conclusion, (1) EYA1 mutations are a major cause of BOR syndrome in Japanese, (2) EYA1 and SIX1 mutations were not a major cause of BOR-related conditions, (3) we demonstrated for the first time that the point mutation (G>T) of the first base of the exon in EYA1 gene induced exon skipping.
Article: Analysis of NPHS1, NPHS2, ACTN4, and WT1 in Japanese patients with congenital nephrotic syndrome[Show abstract] [Hide abstract]
ABSTRACT: Congenital nephrotic syndrome (CNS) causes significant renal failure, and is classified into two types: (1) Finnish type; and (2) other, including diffuse mesangial sclerosis. Mutations of NPHS1 and NPHS2, which encode the slit diaphragm components nephrin and podocin, cause CNS and autosomal-recessive familial steroid-resistant nephrotic syndrome, respectively. Most patients with Finnish-type CNS in Europe and the United States have NPHS1 mutations. However, NPHS2 mutations have been detected in some cases. Mutations in ACTN4, encoding alpha-actinin-4, cause an autosomal-dominant focal segmental glomerulosclerosis. alpha-actinin-4 stabilizes the podocyte cytoskeleton structure, connecting with actin filaments. WT1 mutations, causing Wilm's tumor, have been demonstrated in some CNS patients with diffuse mesangial sclerosis. Systematic investigation of genes for CNS in Japan has never been performed. To clarify the role of mutations in these four genes, we used polymerase chain reaction (PCR) and direct sequencing to investigate all exons and exon-intron boundaries for these genes in 13 unrelated CNS patients from regional pediatric kidney disease centers in Japan. A novel homozygous nonsense mutation of NPHS1, E246X in exon 7, and a novel homozygous deletion mutation of NPHS1, 2156_2163del in exon 16 were detected in one patient each. A novel homozygous nonsense mutation of NPHS2, R196X in exon 5, was found in one patient, and the same heterozygous nonsense mutation was detected in another. No ACTN4 or WT1 mutations were detected. These studies demonstrate that mutation of NPHS1 is not a major cause of CNS in Japanese patients, and that mutation of NPHS2 can be responsible for CNS in this population.
Article: The role of fibroblast growth factor 23 for hypophosphatemia and abnormal regulation of vitamin D metabolism in patients with McCune-Albright syndrome[Show abstract] [Hide abstract]
ABSTRACT: McCune-Albright syndrome (MAS) is sometimes complicated by hypophosphatemia and abnormally low levels of 1,25(OH)(2)D in the presence of hypophosphatemia. Recently, fibroblast growth factor 23 (FGF-23) was reported as a phosphaturic and a causal factor of abnormal vitamin D metabolism. This abnormal phosphate and vitamin D metabolism is well known to be found in oncogenic and X-linked hypophosphatemia. We furthermore reported increased circulating plasma FGF-23 levels in patients with oncogenic and X-linked hypophosphatemia. To determine whether FGF-23 may be involved in the pathogenesis of MAS, we measured plasma FGF-23 levels in six MAS patients. As a control for hypophosphatemia, we also investigated the plasma FGF-23 levels in two patients with hereditary hypophosphatemic rickets with hypercalciuria (HHRH). We also investigated the correlation of plasma FGF-23 levels with serum phosphate and 1,25(OH)(2)D levels after short-term pamidronate therapy in three MAS patients. Plasma FGF-23 levels were significantly increased in patients with MAS compared to normal controls, whereas they were not increased in HHRH patients. Serum phosphate levels of the MAS patients were significantly lower than those observed in normal controls. Plasma FGF-23 levels showed significant negative correlation with serum phosphate concentrations. In three MAS patients, pamidronate therapy decreased plasma FGF-23 levels, which showed significant negative correlation with serum 1,25(OH)(2)D concentrations. These data suggested that FGF-23 is a possible causal factor for hypophosphatemia and abnormal vitamin D metabolism in MAS.
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ABSTRACT: Podocin is an integral membrane protein encoded by NPHS2, which is mapped to 1q25-31 and is exclusively expressed in glomerular podocytes. NPHS2 mutations are responsible for autosomal recessive familial steroid-resistant nephrotic syndrome (SRNS) with minor glomerular abnormalities or focal segmental glomerulosclerosis (FSGS), which is characterized by early childhood onset (age less than 6 years) and rapid progression to chronic renal insufficiency. This gene mutation is also responsible for an adolescent/adult onset form of autosomal recessive familial FSGS with heavy proteinuria. It has been demonstrated that sporadic SRNS and heavy proteinuria are also due to NPHS2 gene mutations. We isolated genomic DNA from 36 Japanese children with chronic renal insufficiency caused by SRNS or heavy proteinuria, and analyzed all eight exons and exon-intron boundaries of NPHS2 using the polymerase chain reaction and direct sequencing. The age at onset of disease was 3.9+/-0.5 years. There were 29 patients with SRNS and 7 with heavy proteinuria without nephrotic syndrome at the onset, but all patients developed chronic renal insufficiency 4.6+/-0.8 years after the onset. A new homozygous missense variant of NPHS2, G34E (G101A) in exon 1, was detected in 1 of 36 patients. However, this homozygous variant was also found in 1 of 44 normal controls, suggesting that the mutation is a polymorphism. Two silent variants (T954C and A1038G) in exon 8 of this gene were also identified in some of the patients and normal controls, indicating that the silent variants are also polymorphisms. There was no significant difference in the genotypic and allelic frequencies of T954C and A1038G polymorphisms between the patients and normal controls. In conclusion, NPHS2 gene mutations are not a major cause of chronic renal insufficiency caused by sporadic SRNS or heavy proteinuria in Japanese children.
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ABSTRACT: Denys-Drash syndrome is a rare disorder consisting of pseudohermaphrodism, Wilms' tumor and nephropathy. We describe here a boy with severe hypospadias and undescended testes, who presented with end-stage renal failure at the age of 1 year and 8 months when he was referred to our hospital. Emergency hemodialysis was performed because of oliguria, edema and severe hypertension, and then peritoneal dialysis was started. The findings of the renal biopsy showed diffuse mesangial sclerosis, consistent with the characteristic change in Denys-Drash syndrome. The analysis of WT1 gene revealed a G-to-A point mutation at 1,186 resulting in a change from Asp to Asn at 396 in exon 9. Since he had no urine output and his kidneys were not functional and in addition, patients with this mutation have been reported to have a high risk of Wilms' tumor, bilateral nephrectomy was performed. The removed kidneys showed no malignancies. Since Denys-Drash syndrome is frequently associated with Wilms' tumor, renal biopsy and gene analysis should be performed on male patients with gonadal anomaly, such as hypospadias and/or undescended testes, and proteinuria.
Article: Novel mutations in the α3 subunit of vacuolar H+-Adenosine Triphosphatase in a Japanese patient with infantile malignant osteopetrosis[Show abstract] [Hide abstract]
ABSTRACT: A case of infantile malignant osteopetrosis is described. The patient died from respiratory hemorrhage at 7 months of age despite treatment that included high doses of active vitamin D and administration of interferon-gamma. A postmortem examination revealed the presence of many osteoclasts in the bone, which lacked ruffled borders. This observation was consistent with the histology of bone reported in Atp6i-knockout mice, which lack the gene encoding the a3 subunit of vacuolar-type H(+)-adenosine triphosphatase (ATPase). Sequence analysis of the TCIRG1 gene encoding the a3 subunit revealed two novel mutations: a deletion/insertion mutation in exon 9 and a T-to-C transition at the splice donor site of intron 19. The former mutation caused a frame shift and premature stop codon. The latter was associated with abnormal splicing, which was confirmed by sequencing the products amplified by reverse transcription-polymerase chain reaction (RT-PCR), using total RNA from the liver specimen as template. Although several mutations in the TCIRG1 gene in infantile malignant osteopetrosis have been reported in other populations, this is the first case of a Japanese patient with a mutation identified in this gene. These results support the important role of the subunit in the function of the proton pump.
Article: Analysis of localization of mutated tissue nonspecific alkaline phosphatase proteins associated with neonatal hypophosphatasia using green fluorescent protein chimeras[Show abstract] [Hide abstract]
ABSTRACT: Hypophosphatasia is associated with a defect of the tissue-nonspecific alkaline phosphatase (TNSALP) gene. The onset and clinical severity are usually correlated in hypophosphatasia; patients with perinatal hypophosphatasia die approximately at the time of birth. In contrast, we describe a male neonatal patient with hypophosphatasia who had no respiratory problems and survived. He was compound heterozygous for the conversion of Phe to Leu at codon 310 (F310L) and the deletion of a nucleotide T at 1735 (delT1735), causing the frame shift with the result of the addition of 80 amino acids at the C-terminal of the protein. Because the C-terminal portion of TNSALP is known to be important for TNSALP to bind to the plasma membrane, the localization of wild-type and mutated TNSALP proteins was analyzed using green fluorescent protein chimeras. The expression vectors containing the complementary DNA of fusion proteins consisting of signal peptide, green fluorescent protein, and wild-type or mutated TNSALP, caused by delT1735 or F310L mutation, were introduced transiently or stably in Saos-2 cells. The delT1735 mutant failed to localize at the cell surface membrane, whereas the wild-type and the F310L mutants were located in the plasma membrane and cytoplasm. The assay for enzymatic activity of TNSALP revealed that the delT1735 mutant lost the activity and that the F310L mutant exhibited an enzymatic activity level that was 72% of the normal level. The F310L mutation was also detected in another neonatal patient with relatively mild (nonlethal) hypophosphatasia (reported in J Clin Endocrinol Metab, 81:4458-4461, 1996), suggesting that residual ALP activity of the F310L mutant contributes to the less severe phenotype. The patient is unique, with respect to a discrepancy between onset and clinical severity in hypophosphatasia.
Article: [A case report of glomerulocystic kidney disease with hypothyroidism in a new born infant].[Show abstract] [Hide abstract]
ABSTRACT: We report a rare case of glomerulocystic kidney disease (GCKD) with congenital hypothyroidism. A gigantic abdominal mass was noted at birth. There was no family history of renal cystic disease. Ultrasonography revealed diffuse granular cysts in the markedly enlarged kidneys. Blood examination showed moderate renal failure and hypothyroidism. Bilateral nephrectomy was conducted at 47 days of age to relieve respiratory failure and severe abdominal distention caused by the growing cystic kidneys. Histological findings of the kidney showed numerous glomerular cysts without renal dysplasia. There were no other malformations. These findings were compatible with GCKD.
Article: Urine screening for hemolytic uremic syndrome associated with pathogenic Escherichia coli O-157 infection
Article: Identification of novel missense mutations (Phe310Leu and Gly439Arg) in a neonatal case of hypophosphatasia[Show abstract] [Hide abstract]
ABSTRACT: Hypophosphatasia is associated with a defect of the tissue-non-specific alkaline phosphatase gene. We performed a mutational analysis in a surviving patient diagnosed at birth as having hypophosphatasia, on the basis of a low level of serum alkaline phosphatase (ALP) activity and characteristic radiographical findings. She had two sisters, one of whom died of respiratory failure complicated by perinatal hypophosphatasia; the other seemed healthy, with a relatively low activity level of ALP. The patient's parents also had low ALP activity. Sequence analysis of the tissue-nonspecific alkaline phosphatase gene was performed, using genomic DNA and total RNA from the skin fibroblasts of the patient and the peripheral mononuclear cells of her parents. The conversion of Phe to Leu at codon 310 (F310L) and Gly to Arg at 439 (G439R) were identified in the patient. Interestingly, the reconstructive experiments demonstrated that the F310L mutant exhibited an ALP activity level 65% of the normal level, whereas the mutant G439R had no activity. Moreover, the digestion by StuI, after a PCR using complementary DNA extracted from fibroblasts of the patient and lymphocytes of her father, revealed a relatively low messenger RNA level of F310L. These findings suggest that the neonatal case of hypophosphatasia was associated with compound mutations, one of which caused the loss of ALP activity and the other of which caused a slight reduction of the ALP activity, with a relatively low level of messenger RNA.
Top Journals
Osaka Medical Center and Research Institute for Maternal and Child HealthIzumi, Ōsaka, Japan
Osaka Minami Medical CenterŌsaka, Ōsaka, Japan
Wakayama Medical University
Wakayama, Wakayama, Japan
- Department of Pediatrics


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Winners : Macro ContestJournal Entry: Sun May 19, 2013, 11:04 AM
Thank you so much everybody
A lot of you participated and there were so many amazing photos !
But i had to decide and here are the winners
You will receive your prizes within the next day
First Place : MarcosRodriguez :
Second Place : OliviaMichalski
Third Place : lindahabiba
Honourable Mentions :
This Journal Skin was designed by Night-Beast
Winners : Macro Contest by Kara-aWatch
©2013-2016 Kara-a
very nice
thank you so much
congrats guys!
Llamas are given!
Congrats to the winners! Such beautiful work everyone!
Congratulations to all
Thank you so much Kara!!! I've got home from a little vacations trip and what a nice surprise!! THANKS A BUNCH!!!
prizes given and feature done. congrats to the winners!
Congrats to all!
So close! Glad to be one of the honorable mentions ^^
Congrats to the winners though!
Congrats to the winners though!


text:
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Great 24 ft Pontoon boat, seats 12, Has aluminum deck under carpet No Mildew smells Low hrs , fish finder,Stereo Cd player, new battery, motor winterized yearly, all accs. included, ropes, anchors, jackets.
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Weather stains on top of front seats, back sundeck has tear on seam of leather. those are the ...
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2000 Powerquest Raizor 22. 22 ft closed bow, Cuddy cabin, Mercuiser 350 mag MPI (300HP), Bravo1 drive 430 hours Rack stored. Tandem axle trailor, new bearings 2015, 4 new tires 2013. Full oem cover. Boat is rack stored at lake Oconee. Very clean, excellent shape. Recent oil change, gear lube change, Impeller new late 2013. No issues, just time for a pontoon. Shown by appointment weekends only ...
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Ahh nothing tastes better than your own foot when it comes to church signs… [Read more...]
Father, Son, Holy Heretic
Ahh nothing tastes better than your own foot when it comes to church signs… [Read more...]
Knock knock. Who's there? Tequila. Tequila who? Tequila is awesome! Until it's not anymore. [Read more...]
You know what persuades me toward a particular way of thinking? Watching two groups with opposing ideologies fight about their differences in the public forum…especially on billboards! [Read more...]
I walk into church and, all of a sudden, the Queer Eye guys jump out and start giving me a makeover! That Carson is such a character… [Read more...]
I once joined a "Pole Dancing for God" class, but he totally kept telling me he was out of ones and would hit me up next time. Sooo not true. [Read more...]
Three benefits to being a sheep: no thinking, no bathing, and all the grass you can handle. Kinda like college! [Read more...]
In honor of World AIDS Day, we have a particularly gay array of signage today. Who's ready to get their intolerance on??? [Read more...]
I was told to dress up as the scariest character I could imagine, so I'm thinking of going with Mark Driscoll… [Read more...]
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Our catalog is full of Subaru Air Mass Meter Hose parts you can order for wholesale prices. AutohausAZ is bar none the best place online to buy auto parts. Our knowledgeable staff is ready to help you find the auto parts you need for your vehicle. We only use your private information to complete your order and keep you apprised. It is always fun to save tons of money on Subaru Air Mass Meter Hose parts. Stop buying from Subaru Air Mass Meter Hose parts stores that outsource their phone support abroad. Our great parts and customer service keeps our customer happy and loyal. When you find you are ready for Subaru Air Mass Meter Hose parts, we are here to offer you quality at low prices.
Mike H. - Scottsdale, AZ: The clutch came in even earlier that you predicted, and at a great price! Thanks.


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SPACE OTTER by WesTalbottWatch
©2013-2016 WesTalbott
Here's a random idea I had and thought would be a fun way to experiment with a watercolor/digital combo approach. I'm thinking I want to try this again with a larger illustration.
This turned out very well.
Very good! Only he needs wearing space suit with jacket and pants, please!
My Luther Lutharie goes to space!
Thanks for the idea!
My Luther Lutharie goes to space!
Thanks for the idea!
A very playful image.
Amazing work!
Cuteness overload.
Not quite the same than Outer Space...
So randomly fun, its awesome! Nicely done!
eee so cute <333
Cute, charming, and lovely use of your media – It looks almost purely traditional, so the smooth mixture works perfectly.
it looks very nice , interesting style
This is quite possibly the cutest thing I have every seen!
Is it a Space Ottersy?
Thanks ! That's a really great technic !
Wow, I love it. How did you process to do it ???


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Law Office of David Wayne Cassidy
Call us: (757) 619-4143
Uncontested Divorce
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If you're looking for high quality personal service, you've come to the right place. At The Law Office of David Wayne Cassidy you will recieve the attention and personal service you've come to expect and enjoy. I am a trial lawyer that reprsents clients in the areas of Criminal Defense, Divorce, and Personal injury at affordable prices. I also provide representation in the areas of business law and small estate planning. I have over 19 years experience as a Virginia licensed attorney. Let me put my experience to work for you.
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For more information please:
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Connect With Us800-299-9470
The Broilmaster Fixed Side Shelf will give you some extra working room when added to your Broilmaster grill. This side shelf will mount to any cart or post-mounted grill head. Includes one side shelf that is fixed and does not fold down
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WACOM Cintiq 21UX is the best thing to come out for artist in years. It's worth every penny. I love this thing so much Im looking at buying one for my home. This has changed my digital art alot and for the better. Anyone else using one of these?
- Mood: Joy


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Best New Hip-Hop Showcase (2013)
Quantized Fitness
Kalyn Heffernan of Wheelchair Sports Camp felt the need to create a quasi-clandestine hip-hop showcase as a way to stay connected to the art form's true creative sources. With the assistance of longtime friend and collaborator Qknox, Heffernan put on the inaugural Quantized Fitness at a local DIY venue in late December and used the occasion to release Qknox's debut mixtape. Inspired in part by L.A.'s Low End Theory, Quantized Fitness will be a monthly curated event for which Heffernan and her crew bring in noteworthy artists from across the hip-hop underground.
More Arts & Entertainment Awards
Best Innovation in a School BuildingMSU Denver's Hotel and Hospitality Learning Center/SpringHill Suites
Best Actor in a ComedyMichael Lopez
The Elaborate Entrance of Chad Deity
Best Supporting Actor in a DramaBen Bonenfant
Best Actor in a DramaJames O'Hagan Murphy


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Mothers Of Intervention: The Operatic Moms Puzzler
It's not easy being a mom, but it's even tougher for mothers in opera. So often they're completely absent while fathers have leading roles in shows like Rigoletto, La traviata, The Flying Dutchman. When depicted at all, operatic moms are usually under supreme stress. They can be murderous, manipulative or simply mad. Only rarely are they the loving moms who brought us into the world. Here your job is to identify the operas and their mothers. Score high and brag to your own sweet (or stressed) mom. Score low and go to your room without supper.
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Login or Sign Up now to post a comment!2 years agodiscomfort into someone I care for? Not even as a training tool. Not any more! And if you run the proverbial line that says 'if you love me you will do this, I would respond, 'if you loved me you would not ask me to do this'! I have known women who have told me that if I love them I would not let them get away with using me. To which I say 'if I love you how could I not trust you indubitably And so when confronted with such honesty I chose to not contend rather than set a situation that82 years agoUncomfortable for a person with my degree of claustrophobia to witness, And while I do feel a lot of angst, I still braved on to watch this in it's entirety, so what does that say about me? I can not fully state I didn't like it because I KNEW what they were about and still I watched. She, they are willing participants and so am I . Butt, even to test my resolve and mettle, I would not voluntarily enter into such fetishism by choice! allow myself to face my claustrophobia? No. Induce72 years agoI could not maintain or trust beyond the moment. Or reciprocate in return if requested!5[[dateAdd]][[commentMessage]]0
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Guerrazzi, Francesco Domenico
Francesco Domenico Guerrazzi (fränchās´kō dō-mā´nēkō gwār-rät´tsē), 1804–73, Italian patriot and writer, b. Livorno. A radical republican and nationalist, he was repeatedly imprisoned for his activities in the Risorgimento. He became minister and dictator (1848–49) of Tuscany in the government established there during the revolution of 1848, and after its fall he was exiled until 1859. After the unification of Italy (1861), Guerrazzi was a member in the Italian parliament until 1870. His romantic historical novels were written as calls to Italian patriotism; the best known of them is L'assedio di Firenze [the siege of Florence] (1836).


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A still from the film, made in 1932
This video was filmed in Burnham in 1932, and is courtesy of British Pathe.
It has uploaded its entire collection of 85,000 historic films, in high resolution, to its YouTube channel, including films from the Maldon district.
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Palin signs new oil tax into law
The ACES plan could increase taxes paid by the oil industry by more than $1.5 billion per year.
David Shurtleff, APRN – Anchorage
You can subscribe to APRN's newsfeeds via email, podcast and RSS. Follow us on Facebook at alaskapublic.org and on Twitter @aprn.


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Reservations for Field Trips & Community Groups
IMPORTANT: This form is only to be completed by school groups and community groups to make reservations to visit the Planetarium during the week and not to reserve seats for our free shows on Saturdays.
TEACHERS: Please review our NEW VA SOLs show information guide for help in selecting a program for your class field trip!
Planetarium Parking
- General Parking Information
- School Bus Parking
- Directions, building information, and an image of the entrance to the planetarium


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Amager Julebryg 2008 is a dark and rich beer with a light creamy foam. Despite the fullness and the abundance of malt, it is not fat or heavy, but somehow rich while also light and fresh. Some tasters will sense spices, but it is pure deception, absolutely no spices are added. Still, there is something Christmassy about this. It is pure malt paradise with lots of Münchner-and dark caramel malt, and plenty of brown sugar and cane sugar for the sweet tooth. 8% abv
The item you have chosen is not in stock in our retail stores or within our main warehouse.
Bell's Brewery "Two Hearted" India Pale Ale, Michigan (12oz)
Bell's Brewery "Two Hearted" India Pale Ale, Michigan 16oz Can
Bell's Brewery "Oberon" Ale, Michigan (12oz)
Russian River Brewing Co. "Damnation" Golden Ale, California (375ml)
Badoit Sparkling Water (750ml) (Glass)


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Counter-Strike: Source blends Counter-Strike's award-winning teamplay action with the advanced technology of Source technology. Featuring state of the art graphics, all new sounds, and introducing physics, Counter-Strike: Source is a must-have for every action gamer. Game updates since mid 2010 are done by Hidden Path Entertainment.
gg_techcenter is a custom map for the Gun Game mode for Counter-Strike : Source. This is a symetric map with two colored parts. All textures and some models are custom made. It gives the map a special ambiance.


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Cultures around the world feast on foods believed to help ensure good luck. Here's are some ideas on how you can eat for fortune in 2014.
Welcome to your discussion forum: Sign in with a Disqus account or your social networking account for your comment to be posted immediately, provided it meets the guidelines. (READ HOW.) Comments made here are the sole responsibility of the person posting them; these comments do not reflect the opinion of Nashoba Publishing. So keep it civil.
( JP Yim )
Kanye West's super strict rules for Yeezy show models
Kanye West had some pretty strict rules for how models at his Yeezy Season 3 fashion extravaganza should display his clothes.


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One of the best things about PC gaming is its adaptability. Like Doom, you can play these games on almost anything.
We asked readers what the hardest game they've ever played is.
Save the world in a little under half-an-hour.
This hardened gamer still has literal nightmares about that VVVVVV level where you hop along the undersides of wildly ping-ponging platforms while trying not to fall into a pit of spikes—you know, that level. And let's not even talk about how quickly my fat fingers fail at the psychedelic Super Hexagon. Terry Cavanagh's notorious for laying out challenges of immense difficulty—what will happen
If you ignore the larger world, will adventure come calling?
Terry Cavanagh, the man behind the indie hits VVVVVV and Super Hexagon (and, as such, the man whose name I've cursed thousands of times) has announced he's no longer to develop Nexus City, or its spin-off game Selma's Story. Nexus City was to be an RPG collaboration between Cavanagh and writer/developer Jonas Kyratzes, whose previous games include The Sea Will Claim Everything and the free Twine
If you can tear yourselves away from the Steam sale counter for just a minute, we bring news of a different sort of countdown, for the perhaps aptly named Super Shock Bundle. You're probably rolling your eyes right now at the presence of yet another indie bundle, but here's why you should consider rolling them back, as painful as that might be: the Super Shock Bundle will feature thirteen games,
You're a tiny triangle trapped inside an imploding hexagon. Bits of hex are rushing inwards to crush you so you have to scoot around the edges of a hexagonal core to survive their assault. The bloopy tones of Chipzel helps to poke your grey matter into a frenzied sort of urgency as the bastard hexagon rotates and changes colour, threatening to crush you in a cold, hexy embrace.
Super Hexagon
Depending on which hip, new ancient texts you keep up with, you may believe 2012 to be The End Times or some other horrifically depressing happenstance - say, the release year of another Twilight movie. But hey, whether our final moments are swift and painless or conducted entirely by a giant floating Edward Cullen face, at least VVVVVV creator Terry Cavanagh is giving you something to look
OK, this is just getting silly. As if Humble Indie Bundle 4 wasn't star-studded enough to begin with, it's now added another nearly nuclear helping of bang for your buck. Specifically, the pot's been sweetened with five games from Humble Indie Bundle 3: Crayon Physics Deluxe, Cogs, VVVVVVV, And Yet It Moves, and Hammerfight.
At A Distance is a co-op puzzle game from Terry Cavanagh, creator of wonderful indie platformer VVVVVV. It's designed to be played by two people on separate, nearby PCs. Each player must wander through a fuzzy environment, messing with everything they come across. Actions in one world will affect the other, and it's up to the players to figure out exactly how through experimentation and shouting.
What's this, every Total War title except Shogun and Shogun 2, with all accompanying DLC for just £8.74 / $12.49? What are you doing to us, Steam sale? I was planning to eat, and perhaps sleep this weekend but NO, you have to throw hundreds of hours of world class strategy gaming at me for a price that my buying finger can't not click on.
Wait, there's more? Gravity mangling platformer VVVVVV,
The Steam sale is doing a good job of expanding our game collections, but what about our ears? They need entertainment too. The Indie Game Music Bundle is here to help. You can pay what you want above a dollar for the collection, which includes sountracks from ten games, including Minecraft, Super Meat Boy, VVVVVV and Cobalt, from artists like C418, Souleye, danny B, Jake "virt" Kaufman. Find the
Super Meat Boy completely won us over with its slightly icky take on the good ol' platform genre. To celebrate its first anniversary, the game has been released as part of a huge bundle on Steam, which includes the original game, Aquaria, Bit.Trip Beat, Bit.Trip Runner, Braid, Gish, Machinarium, VVVVV and World of Goo. You'll also get the music tracks from Super Meat Boy, Braid, Machinarium,
Face-on with the new HTC Vive, and why its new front-facing camera is a big deal.
The Humble Indie Bundle 3 has expanded in all directions. The pay-what-you want package originally offered Crayon Physics Deluxe, Cogs, VVVVVV, And Yet it Moves and Hammerfight, then Mojang threw in a trial to let purchasers play Minecraft for free until August 14. Then rotating robo-blaster Steel Storm jumped in, but that still wasn't enough.
Now, if you pay more than the average
The Humble Indie Bundle is a remarkable success story, since the third version of the pay-what-you-want scheme began last week it's already taken more than $1,000,000 in sales.
The money is split between developers, the Electronic Frontier Foundation, Child's Play and the cost of maintaining the bundle itself, with purchasers getting to determine how much goes to each. Now they've added a
PC Gamer is the global authority on PC games. For more than 20 years we have delivered unrivaled coverage, in print and online, of every aspect of PC gaming. Our team of experts brings you trusted reviews, component testing, strange new mods, under-the-radar indie projects and breaking news around-the-clock. From all over the world we report on the stuff that you'll find most interesting, and gives your PC gaming experience the biggest boost.
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FDA Approves Xgeva to Treat Giant Cell Tumor of the Bone »
"The U.S. Food and Drug Administration today expanded the approved use of Xgeva (denosumab) to treat adults and some adolescents with giant cell tumor of the bone (GCTB), a rare and usually non-cancerous tumor.
GCTB generally occurs in a"...
Read the FDA Approves Xgeva to Treat Giant Cell Tumor of the Bone article »
(Generic versions may still be available.)
Wigraine (ergotamine and caffeine) ® Tablets: Each tablet contains the following:
Ergotamine Tartrate, USP 1 mg
Caffeine, USP 100 mg
Each tablet also contains: Lactose, Magnesium Stearate, Microcrystalline Cellulose, Corn Starch, Glycerin, Acacia Powder, Colloidal Silicon Dioxide, and Purified Water as inactive ingredients.
Wigraine (ergotamine and caffeine) ® tablets are uncoated and prepared to insure rapid disintegration (by an exclusive manufacturing process) and facilitate quick absorption. Rapid onset of effect is important for the satisfactory treatment of acute attacks of vascular headaches.
What are the precautions when taking ergotamine and caffeine (Wigraine)?
Before taking this medication, tell your doctor or pharmacist if you are allergic to ergotamine or caffeine; or to other ergot alkaloids (such as dihydroergotamine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood circulation problems (for example, in your legs, arms/hands, or stomach), certain types of headaches (hemiplegic or basilar migraine), heart problems (such as chest pain, irregular heartbeat, previous heart attack), kidney disease, liver disease, stroke or "mini-stroke" (transient ischemic attack).
Certain conditions can increase...
Last reviewed on RxList: 12/8/2004
This monograph has been modified to include the generic and brand name in many instances.
Wigraine FDA Prescribing Information
Additional Wigraine Information
Wigraine - User Reviews
Wigraine User Reviews
Now you can gain knowledge and insight about a drug treatment with Patient Discussions.
Here is a collection of user reviews for the medication Wigraine sorted by most helpful.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Women's Health
Find out what women really need.


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just a widdle WIP by MrElectrog64Watch
tryin' out a new style. one that's more human....(and it pains me to say so, for some reason)
but ye, 'tis turning out pretty good, at least to me. waddaya think peeps?
I cant wait to see it
I made a MOC that looks like that
when youll upload with the head ide like to see if its better than mine (probably XD)
thanks! he's supposed to be a skeleton that was reinforced with robotic parts.
haven't thought of a name for him yet... XD
though everything else could use work
want my advice?
anylize the humanoid forn with your hands, like a figurine, doll, action figure, trace a drawing, or yourself.
('ts a good excuse to touch yerself)
hrm, I s'pose. but ye, I was usin' a pic of a skeleton for modeling. but I mean, this is about as good as I can make the body while keeping the rib design (the MOC is supposed to be an actual skeleton that is reinforced with robotic parts) so I still need to keep it relatively skinny... 'tis my dilemma
the only real way I could add to the body is if I made the shoulders longer
oh well beats me....


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Since he's a runner type of Guy Do you guys think he would want to draft Kalil instead of I really want blackmon.......
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Since he's a runner type of Guy Do you guys think he would want to draft Kalil instead of I really want blackmon.......
I think Fishers #1 focus is developing Bradford. You can't do that Brandon Gibson and Danario Alexander... However, Blackmon, Gibson, (healthy) Amendola, and Alexander is pretty solid; especially if Pettis develops.
Your best bet would be to trade with Cleveland (so they can lock in RG3). You get both their 1sts this year (at the very least). Take Blackmon at #4, OT/CB at #20, and OT/CB/OLB in the 2nd.
i didnt know that either!! blackmon plese!! and i honestly don't think cleveland will give up both their 1st...because they need to complement rg3 with a WR in the 22nd spot with jeffery,wright, sanu , jones
Last week I heard Fisher interviewed on 101. He laughed at the idea he's a run first head coach.
McNair 3x pro bowler and shared the MVP
Eddie George was a 4x pro bowler
It think he considers himself balance oriented.
I think he will draft blackmon at 2 even if we cant trade down.He sees and understands Sam needs some help to become as good as he can be and i think he has no intentions of setting Sam up with mediocre talent while Fisher is in charge.Fishers knows this is a QB league and what does a Qb need to succedd??Weapons its a fact and im confident Fisher understands that and will ultimately draft blackmon.Remember even though it was a late first he did draft kenny britt with his first round pick so to say he will shy away from a stud WR is an overstatement.


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Amanda Moorghen
Projects Officer
Speech & Debate team
020 7529 1565
Projects Officer
Speech & Debate team
020 7529 1565
Registration for Debate Academy 2016 will open on 1 March 2016. See you then!
Debate Academy offers top quality coaching in debate to all ability levels, delivered by some of the best coaches and debaters in the world. Whether you have little or no experience, or are getting ready for trials for your national debating team, Debate Academy has something to offer you. It also offers the chance for students from a wide range of schools to meet each other, socialise and make friends from around the country and the world.
We offer two courses for 14-18 year olds, as part of the Debate Academy programme. The first is our Mixed Formats Debate Academy and the second is our World Schools' Debate Academy. All courses offer the following:
Debate Academy 2016 will be held from 1 - 6 August at Uppingham School, Rutland. The cost per participant is £495 (full or partial bursaries are available).