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When I can, I try to pitch in; this is how the community works. My first contribution was organizing the Cocomore-sponsored Code Sprints for Drupal 7 and the Drupal 7 release party in late 2010 and early 2011, respectively. I've helped organize and pitched in at DrupalCamps and Drupalcons, wrote a small module that's had some use, helped in various issues queues and was the driving force behind building the "new" Drupal books system on drupal.org (for published books about Drupal, which used to be basically static HTML pages and is now Views-based, with a new content type. I created that content type and the Views displays and staged content and migrated it via a Selenium process. Lately, I've been too busy to take on such tasks, but these things change; look for me at the cons! :-D
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LoMo helps support and grow the Drupal community with the Drupal Association.

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Synonyms of exist in English:
1 animals which existed at some time in the distant past
live, be alive, be living, have life, breathe, draw breath;
be, have being, have existence, be extant
2 the liberal climate that existed during his presidency
remain, obtain, continue, last, endure;
3 she had to exist on an average income of £50 a week
manage, make do, keep going, struggle along, scrape by, keep one's head above water, make ends meet
informal get by, keep the wolf from the door
Definition of exist in:
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- US English synonyms
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Are you Michael A Tangrea?Claim your profile
Publications (52)231.46 Total impact
Article: Abstract 230: Do-It-Yourself expression microdissection (DIY xMD): A low-cost, high-throughput cell and organelle isolation system
- [Show abstract] [Hide abstract]
ABSTRACT: SIVQ-LCM is a new methodology that automates and streamlines the more traditional, user-dependent laser dissection process. It aims to create an advanced, rapidly customizable laser dissection platform technology. In this report, we describe the integration of the image analysis software Spatially Invariant Vector Quantization (SIVQ) onto the ArcturusXT instrument. The ArcturusXT system contains both an infrared (IR) and ultraviolet (UV) laser, allowing for specific cell or large area dissections. The principal goal is to improve the speed, accuracy, and reproducibility of the laser dissection to increase sample throughput. This novel approach facilitates microdissection of both animal and human tissues in research and clinical workflows.
- [Show abstract] [Hide abstract]
ABSTRACT: The development of prognostic and diagnostic biomarkers, such as those from gene expression studies, requires independent validation in clinical specimens. Immunohistochemical analysis on tissue microarrays (TMAs) of formalin-fixed paraffin-embedded tissue is often used to increase the statistical power, and it is used more often than in situ hybridization, which can be technically limiting. Herein, we introduce a method for performing quantitative gene expression analysis across a TMA using an adaptation of 2D-RT-qPCR, a recently developed technology for measuring transcript levels in a histologic section while maintaining 2-dimensional positional information of the tissue sample. As a demonstration of utility, a TMA with tumor and normal human prostate samples was used to validate expression profiles from previous array-based gene discovery studies of prostate cancer. The results show that 2D-RT-qPCR expands the utility of TMAs to include sensitive and accurate gene expression measurements.
Article: Validation of esophageal squamous cell carcinoma candidate genes from high-throughput transcriptomic studies[Show abstract] [Hide abstract]
ABSTRACT: In a recent study, a unique gene expression signature was observed when comparing esophageal squamous cell carcinoma (ESCC) epithelial cells to normal esophageal epithelial cells using laser capture microdissection (LCM) and cDNA microarray technology. To validate the expression of several intriguing genes from that study (KRT17, cornulin, CD44, and EpCAM), we employed two new technologies, expression microdissection (xMD) for high-throughput microdissection facilitating protein analysis and RNAscope for the evaluation of low abundant transcripts in situ. For protein measurements, xMD technology was utilized to specifically procure sufficient tumor and normal epithelium from frozen human tissue for immunoblot analysis of KRT17 (CK17) and cornulin. A novel in situ hybridization method (RNAscope) was used to determine the transcript level of two relatively low expressed genes, CD44 and EpCAM in both individual formalin-fixed paraffin-embedded (FFPE) tissue sections and in an ESCC tissue microarray (TMA). The results successfully confirmed the initial expression pattern observed for all four genes, potentially implicating them in the pathogenesis of ESCC. Additionally, the study provides important methodological information on the overall process of candidate gene validation.
Article: Abstract 3211: Proteomic analysis of nuclei dissected from FFPE tissue using expression microdissection.
Article: Proteomic Analysis of Nuclei Dissected from Fixed Rat Brain Tissue Using Expression Microdissection[Show abstract] [Hide abstract]
ABSTRACT: Expression Microdissection (xMD) is a high-throughput, operator-independent technology that enables the procurement of specific cell populations from tissue specimens. In this method, histological sections are first stained for cellular markers via either chemical or immuno-guided methods, placed in close contact with an ethylene vinyl acetate (EVA) film, and exposed to a light source. The focal, transient heating of the stained cells or subcellular structures melts the EVA film selectively to the targets for procurement. In this report, we introduce a custom-designed flashcube system that permits consistent and reproducible microdissection of nuclei across an FFPE rat brain tissue section in milliseconds. In addition, we present a method to efficiently recover and combine captured proteins from multiple xMD films. Both light and scanning electron microscopy demonstrated captured nuclear structures. Shotgun proteomic analysis of the samples showed a significant enrichment in nuclear localized proteins, with an average 25% of recovered proteins localized to the nucleus, versus 15% for whole tissue controls (p<0.001). Targeted mass spectrometry using Multiple Reaction Monitoring (MRM) showed more impressive data, with a 3-fold enrichment in histones, and a concurrent depletion of proteins localized to the cytoplasm, cytoskeleton, and mitochondria. These data demonstrate that the flashcube-xMD technology is applicable to the proteomic study of a broad range of targets in molecular pathology.
Article: Measuring collective cell movement and extracellular matrix interactions using magnetic resonance imaging[Show abstract] [Hide abstract]
ABSTRACT: Collective cell behaviors in migration and force generation were studied at the mesoscopic-level using cells grown in a 3D extracellular matrix (ECM) simulating tissues. Magnetic resonance imaging (MRI) was applied to investigate dynamic cell mechanics at this level. MDCK, NBT2, and MEF cells were embedded in 3D ECM, forming clusters that then migrated and generated forces affecting the ECM. The cells demonstrated MRI contrast due to iron accumulation in the clusters. Timelapse-MRI enabled the measurement of dynamic stress fields generated by the cells, as well as simultaneous monitoring of the cell distribution and ECM deformation/remodeling. We found cell clusters embedded in the 3D ECM can exert translational forces to pull and push, as well as torque, their surroundings. We also observed that the sum of forces generated by multiple cell clusters may result in macroscopic deformation. In summary, MRI can be used to image cell-ECM interactions mesoscopically.
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ABSTRACT: The discovery of effective cancer biomarkers is essential for the development of both advanced molecular diagnostics and new therapies/medications. Finding and exploiting useful clinical biomarkers for cancer patients is fundamentally linked to improving outcomes. Towards these aims, the heterogeneous nature of tumors represents a significant problem. Thus, methods establishing an effective functional linkage between laser capture microdissection (LCM) and mass spectrometry (MS) provides for an enhanced molecular profiling of homogenous, specifically targeted cell populations from solid tumors. Utilizing frozen tissue avoids molecular degradation and bias that can be induced by other preservation techniques. Since clinical samples are often of a small quantity, tissue losses must be minimized. Therefore, all steps are carried out in the same single tube. Proteins are identified through peptide sequencing and subsequent matching against a specific proteomic database. Using such an approach enhances clinical biomarker discovery in the following ways. First, LCM allows for the complexity of a solid tumor to be reduced. Second, MS provides for the profiling of proteins, which are the ultimate bio-effectors. Third, by selecting for tumor proper or microenvironment-specific cells from clinical samples, the heterogeneity of individual solid tumors is directly addressed. Finally, since proteins are the targets of most pharmaceuticals, the enriched protein data streams can then be further analyzed for potential biomarkers, drug targets, pathway elucidation, as well as an enhanced understanding of the various pathologic processes under study. Within this context, the following method illustrates in detail a synergy between LCM and MS for an enhanced molecular profiling of solid tumors and clinical biomarker discovery.
Article: Optimal Molecular Profiling of Tissue and Tissue Components: Defining the Best Processing and Microdissection Methods for Biomedical Applications[Show abstract] [Hide abstract]
ABSTRACT: Isolation of well-preserved pure cell populations is a prerequisite for sound studies of the molecular basis of any tissue-based biological phenomenon. This updated chapter reviews current methods for obtaining anatomically specific signals from molecules isolated from tissues, a basic requirement for productive linking of phenotype and genotype. The quality of samples isolated from tissue and used for molecular analysis is often glossed over or omitted from publications, making interpretation and replication of data difficult or impossible. Fortunately, recently developed techniques allow life scientists to better document and control the quality of samples used for a given assay, creating a foundation for improvement in this area. Tissue processing for molecular studies usually involves some or all of the following steps: tissue collection, gross dissection/identification, fixation, processing/embedding, storage/archiving, sectioning, staining, microdissection/annotation, and pure analyte labeling/identification and quantification. We provide a detailed comparison of some current tissue microdissection technologies and provide detailed example protocols for tissue component handling upstream and downstream from microdissection. We also discuss some of the physical and chemical issues related to optimal tissue processing and include methods specific to cytology specimens. We encourage each laboratory to use these as a starting point for optimization of their overall process of moving from collected tissue to high-quality, appropriately anatomically tagged scientific results. Improvement in this area will significantly increase life science quality and productivity. The chapter is divided into introduction, materials, protocols, and notes subheadings. Because many protocols are covered in each of these sections, information relating to a single protocol is not contiguous. To get the greatest benefit from this chapter, readers are advised to read through the entire chapter first, identify protocols appropriate to their laboratory for each step in their workflow, and then reread entries in each section pertaining to each of these single protocols.
Article: Three-Dimensional mRNA Measurements Reveal Minimal Regional Heterogeneity in Esophageal Squamous Cell Carcinoma[Show abstract] [Hide abstract]
ABSTRACT: The classic tumor clonal evolution theory postulates that cancers change over time to produce unique molecular subclones within a parent neoplasm, presumably including regional differences in gene expression. More recently, however, this notion has been challenged by studies showing that tumors maintain a relatively stable transcript profile. To examine these competing hypotheses, we microdissected discrete subregions containing approximately 3000 to 8000 cells (500 to 1500 μm in diameter) from ex vivo esophageal squamous cell carcinoma (ESCC) specimens and analyzed transcriptomes throughout three-dimensional tumor space. Overall mRNA profiles were highly similar in all 59 intratumor comparisons, in distinct contrast to the markedly different global expression patterns observed in other dissected cell populations. For example, normal esophageal basal cells contained 1918 and 624 differentially expressed genes at a greater than twofold level (95% confidence level of <5% false positives), compared with normal differentiated esophageal cells and ESCC, respectively. In contrast, intratumor regions had only zero to four gene changes at a greater than twofold level, with most tumor comparisons showing none. The present data indicate that, when analyzed using a standard array-based method at this level of histological resolution, ESCC contains little regional mRNA heterogeneity.
Conference Paper: High-throughput Microdissection for the Molecular Analysis of Breast and Prostate Tumor Specimens[Show abstract] [Hide abstract]
ABSTRACT: Laser capture microdissection (LCM) is a technology developed in the mid-1990's to allow users to isolate specific cell populations via microscopic visualization. Recently, our lab has developed a novel, high-throughput microdissection technology termed Expression Microdissection (xMD). Using immunohistochemistry (IHC) to determine the target cells or subcellular targets to be isolated, xMD can procure specific targets without the use of expensive optics. In this presentation, we demonstrate the utility of the technology using a handheld xMD device to microdissect tumor epithelium from whole slide formalin-fixed paraffin-embedded (FFPE) breast and ethanol-fixed paraffin-embedded (EFPE) prostate tumor specimens. Following microdissection, the user may isolate RNA from the procured cells and perform RT-qPCR analysis. This innovative handheld device allows users to specifically microdissect in seconds for downstream molecular analysis.
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ABSTRACT: To fully integrate molecular analysis with histology, it is essential to further develop and evaluate in situ tissue section-based technologies that are sensitive, quantitative, and high-throughput. In the proteomics field, immunohistochemistry (IHC) is the method of choice for in situ measurement of protein levels in histological sections. However, matrix-assisted laser desorption ionization-imaging mass spectrometry (MALDI-IMS) and related methods are emerging as additional multiplex in situ protein analysis tools. In this review, we discuss the application of these techniques in biomedical research and describe three newly developed technologies: multiplex tissue immunoblotting, indirect layered peptide array, and layered electrophoretic transfer (LET). In particular, we emphasize the LET technology as a novel in situ separation tool that allows for a more comprehensive proteomic analysis of a tissue sample while maintaining the important two-dimensional histological architecture.
Article: Identification of unique expression signatures and therapeutic targets in esophageal squamous cell carcinoma[Show abstract] [Hide abstract]
ABSTRACT: Esophageal squamous cell carcinoma (ESCC), the predominant histological subtype of esophageal cancer, is characterized by high mortality. Previous work identified important mRNA expression differences between normal and tumor cells; however, to date there are limited ex vivo studies examining expression changes occurring during normal esophageal squamous cell differentiation versus those associated with tumorigenesis. In this study, we used a unique tissue microdissection strategy and microarrays to measure gene expression profiles associated with cell differentiation versus tumorigenesis in twelve cases of patient-matched normal basal squamous epithelial cells (NB), normal differentiated squamous epithelium (ND), and squamous cell cancer. Class comparison and pathway analysis were used to compare NB versus tumor in a search for unique therapeutic targets. As a first step towards this goal, gene expression profiles and pathways were evaluated. Overall, ND expression patterns were markedly different from NB and tumor; whereas, tumor and NB were more closely related. Tumor showed a general decrease in differentially expressed genes relative to NB as opposed to ND that exhibited the opposite trend. FSH and IgG networks were most highly dysregulated in normal differentiation and tumorigenesis, respectively. DNA repair pathways were generally elevated in NB and tumor relative to ND indicating involvement in both normal and pathological growth. PDGF signaling pathway and 12 individual genes unique to the tumor/NB comparison were identified as therapeutic targets, and 10 associated ESCC gene-drug pairs were identified. We further examined the protein expression level and the distribution patterns of four genes: ODC1, POSTN, ASPA and IGF2BP3. Ultimately, three genes (ODC1, POSTN, ASPA) were verified to be dysregulated in the same pattern at both the mRNA and protein levels. These data reveal insight into genes and molecular pathways mediating ESCC development and provide information potentially useful in designing novel therapeutic interventions for this tumor type.
Article: A dynamic magnetic shift method to increase nanoparticle concentration in cancer metastases: a feasibility study using simulations on autopsy specimens[Show abstract] [Hide abstract]
ABSTRACT: A nanoparticle delivery system termed dynamic magnetic shift (DMS) has the potential to more effectively treat metastatic cancer by equilibrating therapeutic magnetic nanoparticles throughout tumors. To evaluate the feasibility of DMS, histological liver sections from autopsy cases of women who died from breast neoplasms were studied to measure vessel number, size, and spatial distribution in both metastatic tumors and normal tissue. Consistent with prior studies, normal tissue had a higher vascular density with a vessel-to-nuclei ratio of 0.48 ± 0.14 (n = 1000), whereas tumor tissue had a ratio of 0.13 ± 0.07 (n = 1000). For tumors, distances from cells to their nearest blood vessel were larger (average 43.8 μm, maximum 287 μm, n ≈ 5500) than normal cells (average 5.3 μm, maximum 67.8 μm, n ≈ 5500), implying that systemically delivered nanoparticles diffusing from vessels into surrounding tissue would preferentially dose healthy instead of cancerous cells. Numerical simulations of magnetically driven particle transport based on the autopsy data indicate that DMS would correct the problem by increasing nanoparticle levels in hypovascular regions of metastases to that of normal tissue, elevating the time-averaged concentration delivered to the tumor for magnetic actuation versus diffusion alone by 1.86-fold, and increasing the maximum concentration over time by 1.89-fold. Thus, DMS may prove useful in facilitating therapeutic nanoparticles to reach poorly vascularized regions of metastatic tumors that are not accessed by diffusion alone.
Article: Differential vitamin D 24-hydroxylase/ CYP24A1 gene promoter methylation in endothelium from benign and malignant human prostate[Show abstract] [Hide abstract]
ABSTRACT: Epigenetic alterations occur in tumor-associated vessels in the tumor microenvironment. Methylation of the CYP24A1 gene promoter differs in endothelial cells isolated from tumors and non-tumor microenvironments in mice. The epigenetic makeup of endothelial cells of human tumor-associated vasculature is unknown due to difficulty of isolating endothelial cells populations from a heterogeneous tissue microenvironment. To ascertain CYP24A1 promoter methylation in tumor-associated endothelium, we utilized laser microdissection guided by CD31 immunohistochemistry to procure endothelial cells from human prostate tumor specimens. Prostate tissues were obtained following robotic radical prostatectomy from men with clinically localized prostate cancer. Adjacent histologically benign prostate tissues were used to compare endothelium from benign versus tumor microenvironments. Sodium bisulfite sequencing of CYP24A1 promoter region showed that the average CYP24A1 promoter methylation in the endothelium was 20% from the tumor microenvironment compared with 8.2% in the benign microenvironment (p< 0.05). A 2-fold to 17-fold increase in CYP24A1 promoter methylation was observed in the prostate tumor endothelium compared with the matched benign prostate endothelium in four patient samples, while CYP24A1 remained unchanged in two patient sample. In addition, there is no correlation of the level of CYP24A1 promoter methylation in prostate tumor-associated endothelium with that of epithelium/stroma. This study demonstrates that the CYP24A1 promoter is methylated in tumor-associated endothelium, indicating that epigenetic alterations in CYP24A1 may play a role in determining the phenotype of tumor-associated vasculature in the prostate tumor microenvironment.
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ABSTRACT: Measurement of mRNA levels across tissue samples facilitates an understanding of how genes function and what their roles are in disease. Quantifying low-abundance mRNA requires a workflow that preserves spatial information, isolates RNA, and performs reverse-transcriptase quantitative polymerase chain reaction (RT-qPCR). This is complex because these steps are typically performed in three separate platforms. In the present study, we describe two-dimensional RT-qPCR (2D-RT-qPCR), a method that quantifies RNA across tissues sections in a single integrated platform. The method uses the grid format of a multi-well plate to macrodissect tissue sections and preserve the spatial location of the RNA; this also eliminates the need for physical homogenization of the tissue. A new lysis and nucleic acid purification protocol is performed in the same multi-well plate, followed by RT-qPCR. The feasibility 2D-RT-qPCR was demonstrated on a variety of tissue types. Potential applications of the technology as a high-throughput tissue analysis platform are discussed.
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ABSTRACT: Laser-based microdissection facilitates the isolation of specific cell populations from clinical or animal model tissue specimens for molecular analysis. Expression microdissection (xMD) is a second-generation technology that offers considerable advantages in dissection capabilities; however, until recently the method has not been accessible to investigators. This protocol describes the adaptation of xMD to commonly used laser microdissection instruments and to a commercially available handheld laser device in order to make the technique widely available to the biomedical research community. The method improves dissection speed for many applications by using a targeting probe for cell procurement in place of an operator-based, cell-by-cell selection process. Moreover, xMD can provide improved dissection precision because of the unique characteristics of film activation. The time to complete the protocol is highly dependent on the target cell population and the number of cells needed for subsequent molecular analysis.
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ABSTRACT: Laser capture microdissection (LCM) facilitates procurement of defined cell populations for study in the context of histopathology. The morphologic assessment step in the LCM procedure is time consuming and tedious, thus restricting the utility of the technology for large applications. Here, we describe the use of Spatially Invariant Vector Quantization (SIVQ) for histological analysis and LCM. Using SIVQ, we selected vectors as morphologic predicates that were representative of normal epithelial or cancer cells and then searched for phenotypically similar cells across entire tissue sections. The selected cells were subsequently auto-microdissected and the recovered RNA was analyzed by expression microarray. Gene expression profiles from SIVQ-LCM and standard LCM-derived samples demonstrated highly congruous signatures, confirming the equivalence of the differing microdissection methods. SIVQ-LCM improves the work-flow of microdissection in two significant ways. First, the process is transformative in that it shifts the pathologist's role from technical execution of the entire microdissection to a limited-contact supervisory role, enabling large-scale extraction of tissue by expediting subsequent semi-autonomous identification of target cell populations. Second, this work-flow model provides an opportunity to systematically identify highly constrained cell populations and morphologically consistent regions within tissue sections. Integrating SIVQ with LCM in a single environment provides advanced capabilities for efficient and high-throughput histological-based molecular studies.
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Last year, people from 47 states came to see the Virginia International Tattoo during its performances at Norfolk Scope.
That means three states were not represented, which means there is still room to grow.
This year's tattoo, from April 21-24 at Scope, will mark the event's 20th anniversary — and at a news conference Friday, organizers made it clear they have big plans.
"It has been amazing to observe how the tattoo has grown over the years," Virginia Arts Festival board chairman Tommy Rueger said. "At the first one in 1997, the attendance was 6,000 and we thought that was pretty good. At last year's, we had 37,000, and I can assure you that number...


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Posted :
Monday, November 7, 2011 6:58:52 PM(UTC)
Rank: Premier Member
Joined: 10/13/2006(UTC)
Location: Green Bay, WI
Applause Given: 2,250
Applause Received: 3,314
Joe Posnanski
February 7, 2011 said:
ARLINGTON, Texas -- In the happy child's dream, of course, the pass is always complete. That's how it works with kids playing football in the backyard. It's always third-and-10, it's the fourth quarter, it's the Super Bowl. In the dream, every receiver is covered, but throwing the ball away is not an option, and taking a sack is not an option, and the sound of footsteps grows louder, they are getting closer, time runs out. In the dream -- but wait! There's an glimmer of something. A tiny opening. A receiver's hand. Something to aim at. The throw will have to be perfect. But if it's thrown just right ...
In the dream, the pass is always completed. Success is so easy to imagine when you're a kid. And maybe that was Aaron Rodgers' secret Sunday night under the world's largest television screen in America's biggest game. Maybe even after everything that comes with being an adult and the Green Bay Packers quarterback -- even after dealing with the absurd pressure of replacing the most popular man in the history of Wisconsin, even after Rodgers' first dreadful season, after absorbing the thrashings of a league-high 50 sacks in the second season, after this wonderful and trying Packers season with two concussions, beat up teammates and a five-week series of must-win games -- maybe even after all that he still had enough of that little kid in him to believe.
For a long night in Super Bowl XLV, the Green Bay Packers always seemed one great play away from finishing off Pittsburgh. There were all sorts of clashing theories going into the game, like always, but one thing everyone seemed to agree on was that the game would be close. There did not seem a reasonable scenario for a blowout. Both teams came in with terrific quarterbacks and terrific defenses and a certain faith in their own team's history. The Steelers have won six Super Bowl trophies, more than any other team, and those Super Bowl trophies are named for the Packers legendary coach Vince Lombardi. Players on both teams are taught from their first day that winning is sewn into their uniforms.
Still ... for a good while this game looked to be a Packers runaway. They built a 21-3 lead late in the second quarter, largely thanks to two Pittsburgh turnovers (an unforeseen development -- the Steelers were plus-17 on turnovers during the season). At that moment, the Steelers seemed muddled; they looked uncertain how to attack the Packers defense (they came in with a game plan of quick outs to wide receivers but were being neutralized), and they looked even more uncertain on how to deal with Rodgers.
"He's an incredibly accurate quarterback," Steelers defensive back Troy Polamalu said, and Polamalu is right, and it seemed for much of the game the Steelers best plan of defense was to hope for Packers receivers to drop passes. Lucky for them, the Packers receivers often obliged. Jordy Nelson, who caught nine passes for 140 yards and a touchdown, also dropped at least two critical passes. James Jones dropped a pass over the middle at the beginning of the third quarter that might have turned into a 75-yard touchdown -- there wasn't a defender anywhere near him. Brett Swain dropped a critical third down pass late in the third quarter.
Well, it had to be that way: Winning just couldn't be that easy, not for Green Bay, not after this crazy season when the Packers had all kinds of injuries and overtime losses. The Packers were 8-6 with two weeks left in the season, and at that point they knew that to get where they expected to go they would have to win every game for the rest of the season. This included a three-week playoff road trip, first to Michael Vick's Philadelphia, then to Atlanta and the 13-3 Falcons, then finally to familiar Chicago. Of course, they won five in a row.
But none of it was easy (well, the Atlanta victory was surprisingly easy), and this wouldn't be easy either. The Steelers scored a touchdown at the end of the first half, another at the start of the second, and the score was 21-17, and for the rest of the way the game was as tight and tense and violent and unpredictable as expected. The Steelers turned the ball over a third time, and the Packers scored another touchdown -- Aaron Rodgers to a wide open Greg Jennings crossing the back of the end zone. Polamalu was the culprit there ("That was completely my fault. Earlier in the game they ran Jennings down the middle and I was anticipating the same play, and I guessed wrong.")
Then, Pittsburgh's Ben Roethlisberger -- who has already been quarterback on two Super Bowl winners -- brought the Steelers back on a convincing seven-play, 66-yard touchdown drive. His 25-yard touchdown pass to Mike Wallace came with 7:34 left. The Steelers had to feel good about their chances. Their offense seemed to be humming, finally. Green Bay led by only three. The Packers don't have the running game to run out the clock in the fourth quarter -- it's the one noticeable flaw in an almost complete team. The Packers and Rodgers had to keep throwing it, and everybody knew it.
"We put the game on Aaron Rodgers shoulders," Packers coach Mike McCarthy said rather bluntly.
On first down, Rodgers was sacked. On third down, the Packers were called for a false start. And so, that left the Aaron Rodgers in the happy child's dream scenario -- it was third-and-10, it was the fourth quarter, it was the Super Bowl. Rodgers dropped back and scanned the field and he saw that every receiver was covered. But throwing the ball away was not an option, taking a sack was not an option, not in this moment. The Packers could not give the ball back to the Steelers now. The sound of footsteps grew louder, the Steelers defenders were getting closer, time was running out. One of the Steelers' plans to win was to hit Aaron Rodgers. They had hit him often throughout the game.
Then Rodgers saw something -- call it a glimmer. On replays, from any angle, it is actually hard to see what he saw. Greg Jennings was double covered -- Pittsburgh's Ike Taylor was in front and the defensive player of the year Troy Polamalu was behind. From the camera angle behind the quarterback, Jennings looked to be completely hidden by Taylor. But Rodgers saw that little something. He has run this play a thousand times. He's thought about it a million times. He grew up near San Francisco, where he watched Joe Montana and Steve Young fit passes into impossibly tight spaces when the moment was big. He spent countless hours in the backyard pretending to be them. Now, he wasn't pretending. He pulled back and he unleashed a throw over the middle.
The ball skimmed an inch over Taylor's hands, maybe less than an inch. And it zipped into Jennings' hands. Jennings caught it ran forward and gained 31 yards, a first down, put the Packers in Pittsburgh territory.
"The ball just got over the top of [Taylor's hands]," Jennings would say.
"He put the ball in a really tight space," Polamalu said.
"I trust Greg there to make a play," Rodgers said. "I'm just trying to give him a chance."
The pass did not score a touchdown. It did not give Green Bay an insurmountable lead. It did not put away the Pittsburgh Steelers. But in many ways, it was the play of the game. In that moment, there was simply nothing Pittsburgh could do. After the game, Pittsburgh coach Mike Tomlin said what coaches say: "They made plays." But he undoubtedly meant this play. The Steelers had the defense. They had the momentum. They had the quarterback in their sights. Aaron Rodgers made a play.
The rest is anticlimax. The Packers were able to run the clock down to almost two minutes, and they settled for a field goal to take a 31-25 lead (even with that Rodgers was furious that his team did not punch it into the end zone and finally close it out). Then the Steelers had one last hope -- they got the ball at their own 13 with 1:59 left. Roethlisberger hit one pass for 15, but then the drive stalled. And when the Steelers faced fourth-and-five, well, this was not Big Ben's day for childhood dreams. His throw was high. And the game was finally over.
Rodgers was the game's MVP, of course. His numbers -- 24 of 39, 304 yards, 3 touchdowns, 0 interceptions -- are impressive enough but would have been even better with more reliable pass catching. Anyway, with Rodgers it has always been about more than his impressive numbers.
When he came out of California, he was talked about as the No. 1 overall pick in the draft. Instead, he plummeted to No. 24 and Green Bay. When he went to the Packers, he found himself sitting behind the legend, Brett Favre. He was basically a nonentity. And then before the 2008 season, the Packers and Favre parted ways, and it wasn't a clean departure, and it left a lot of anger and disappointment and disarray. And suddenly Aaron Rodgers was the starting quarterback of the Green Bay Packers, and he was asked to pick up the pieces.
"I've never felt like there was a monkey on my back," Rodgers would say after the game ended. "The organization stood behind me. They believed in me. That's all I needed." But it's easy to say that when covered in confetti. Rodgers endured through a lot of hard work, a lot of dedication to the game, and by continuing to believe in himself even when it seemed crazy.
And that's why it was so touching when on Sunday night, after winning the Super Bowl, he remembered being young. Players often talk about those childhood moments in the backyard pretending to hit home runs like Hank Aaron or hit long shots like Reggie Miller or throw touchdowns like Joe Montana. A choice few get their moment. But until they get that moment, they never know for sure if it's real or still a dream.
"How do you feel?" someone asked Aaron Rodgers.
"I'm not sure," he said, and he smiled. "It hasn't sunk in yet." You got the feeling that once it does sink in, he will feel pretty good.
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"I do not think there is any thrill that can go through the human heart like that felt by the inventor as he sees some creation of the brain unfolding to success... such emotions make a man forget food, sleep, friends, love, everything." - Nikola Tesla
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: Would rather watch 12 do this: https://www.yahoo.com/sports/video/aaron-rodgers-drops-lengthy-birdie-224852502.html
: anyine want nascar in chat
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: Quinton Coples released by Dolphins. Would love to see him brought in for a looksee.
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Road To Super Bowl 50
Sunday, Sep 13 @ 12:00 PM
at Bears
31 - 23
Sunday, Sep 20 @ 7:30 PM
27 - 17
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38 - 28
Sunday, Oct 4 @ 3:25 PM
at 49ers
17 - 3
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24 - 10
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27 - 20
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10 - 29
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29 - 37
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Sunday, Nov 22 @ 3:25 PM
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30 - 13
Thursday, Nov 26 @ 7:30 PM
13 - 17
Thursday, Dec 3 @ 7:25 PM
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27 - 23
Sunday, Dec 13 @ 3:25 PM
28 - 7
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text:
When I joined Microsoft back in 2001, Exchange 2000 was the latest and greatest in messaging, Windows Mobile was something you would hang in a baby's bedroom and having your emails read out to you was 'Star Trek stuff'. How things have changed over the last 6 years.
Back then, I had a lot of 'deadtime' during which I would be away from my desk and therefore unable to deal with the emails that were flowing in. Don't get me wrong, its not that I needed to be connected to my email because the world would stop revolving is someone wasn't able to get hold of me, its more that I wanted to keep it under control by deleting and filing emails that didn't require a response from me. Along comes Windows Mobile (or Smartphone in those days) to the rescue.
I got my first Smartphone, an 'Orange SPV' or 'Canary' back in 2002 and started to use it with Exchange 2000 (with MIIS) and then Exchange 2003 to sync my email. When I sat on the train into London or had a few spare minutes while waiting for the bus I could sift through my email, delete any 'spam' (stuff I am cc'd on but don't need to keep), read my daily news summaries and catchup on any communications sent from Redmond during the night. When I finally sat down at my desk I could start work straight away rather than spending the first hour of the day doing mailbox maintenance. With an average of 1hr spent on mailbox maintenance (from my own experience), 260 work days a year and 5 years gone by, its saved me 1300 hours or 54 days worth of time. This is great, but there is still one more place where 'deadtime lived', until now.
The car has always been one of those places where, for obvious reasons, its not been possible to read email. This has instead been the time traditionally when people have scheduled conference calls or just simply sat stuck in traffic while traveling into the office. Traveling in the car has always been deadtime for me and even if I didn't want to sort through my email during this time, it been impossible to phone people without the risk of using the phone manually and breaking the law. This has all changed now as I have access to Outlook Voice Access.
Outlook Voice Access enables me to do a few key things while driving to work in the car:-
I have only been using it for a while but it has already been comfortably inserted into my daily routine and I know that when I get in the office, my inbox is in a state where I can get on with my work. That combined with the fact that I can safely and legally phone people from my phone means I would never want to go back to not having OVA.
Hello OVA, Bye bye deadtime!


text:
Pros: [ ] family suite is comfortable it has two interconnected rooms with two attached bathrooms one in each room. [ ] bathroom is clean, top shower is there. Water was warm and soothing [ ] food is good and quantity is just right, no wastage sewain kheer was very nice. [ ] location is 5km away from the mall... More
We are searching for
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This site does not currently take bookings here on Pitchup.com.
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A great park with lots of facilities including a large indoor pool complex, Primrose Valley has everything the family needs on a seaside holiday. With a fabulous water fun complex, from flumes, slides and water play areas to large indoor and outdoor pools, and fantastic holiday facilities from the funfair and climbing wall to tennis courts and go karts.
Primrose Valley is attractively landscaped in a stunning coastal position overlooking Filey Bay with direct beach access.
Substantially developed in recent years to become Haven's flagship Park in the North, Primrose Valley's all-action facilities include a terrific multi-level pool complex and water fun area, two more pools, a boating lake, fun fair, coarse fishing lake - there's even an adventure ropes course. If you and the kids simply want it all, here's the very best of everything.
Feel free to fill each day in just your own way. Every family is different of course, but a typical day might begin with a lazy lie in or a family 'wake 'n' shake' session. It could be a morning in the multi-level heated pool complex with fun pools and SplashZone or trying the ropes course & zip wire.
Lunch out at a great little pub or pop into our Mash and Barrel: lounge-bar-café. Spend the afternoon at the FunFair and Fun Tower, exploring Yorkshire or enjoying a relaxing time on the boating lake. In the early evening enjoy a stroll along the seafront, a sunset bike ride or a barbecue. Then head off to the ShowBar for a drink, live music and dancing. So, whether it's out and about or staying on the park, you're sure to have a great holiday at Primrose Valley.
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Use the 'Special requests' box on the booking page to ask to be sited together when booking multiple pitches: the campsite or park will try to grant your request.
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Candlelight shines soft and enchanting through handcrafted candle holders, etched with a subtle frosted texture and incised with hand-cut ovals and lines. Created in India by highly skilled artisans whose unique body of work is distinguished by intricate cutwork that imparts mesmerizing pattern and texture.
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text:
Smaug The Magnificent by masterHalflingWatch
©2013-2016 masterHalfling
Second attempt to draw Smaug.
I want to see him so hard. Can't wait for the second movie!
I want to see him so hard. Can't wait for the second movie!
wow this is amazing! I loveeeee the detail. You're very talented!
This is a word for amazing that hasn't been invented yet!
No matter what you do, don't look Old Smaug in the eye. You'll fall under his Dragon-Spell!
I'll betcha anything that that's exactly what Smaug will look like in the next movie.
This is incredible! The colors and details are amazing!


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United Nations Secretary-General Pays Tribute to Nelson Mandela
Ban Ki-moon describes Nelson Mandela as a man of peace.
91 World Leaders to Pay Tribute to Nelson Mandela
Four American presidents are among those joining South Africa in saying goodbye to Mandela.
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text:
Liara T'soni by DrawingisLife92Watch
©2010-2016 DrawingisLife92
I really love this character and i decided to draw her( Ye i know very original uh? XD)
So here's my portrait of Liara T'soni_Mass Effect
So here's my portrait of Liara T'soni_Mass Effect
Hidden by Commenter
i love the expression on her face
She's beautiful! Great art! Please, if possible, add a bigger resolution (1920x1080) download option, I'd like to use it as wallpaper
Thanks...now it's 1600 wide if you want to download...I hope it's enough ^^ Thanks again
I wish this was available as a high resolution vertical poster with the background cropped a bit. I so much want to put this on my wall. Simple and elegant, just astonishing.
What did you use to create this if you don't mind me asking?
What did you use to create this if you don't mind me asking?
It's made in Photoshop CS5 using a tablet ^^
Thanks for the compliments but i really didn't get how u would like it to be o.O
Thanks for the compliments but i really didn't get how u would like it to be o.O
Nicely done!! You capture her eyes so well!
How can we post to our Desktop without the DA logo in the center? Love this portrait!
sorry it's because a lot of people loves to steal art... I'll pm u a version without the logo if u like
It's greatest moment with Liara in game. Art is cool
Great job, i'm amazed! Unlike a lot of Liara fan art that we see around here, this one really captures her expression!
Thanks a lot...i'm glad you got this feeling from my drawing xD thanks again
Ah Liara... Wonderful work !
Very well done, this is now my wallpaper
this needs to be a print! now!
Too much negative space! You should crop it in! It would do your drawing much more justice! Very nice work though! LOVE IT!
You are absolutely right but i kinda get bored after some time working on this so i'll probably finish this later
Thanks XD
Thanks XD
Beautiful ^^
Nice!! I love it
Love it.
Lovely ^^
Liara looks great
Her face is very nice
Many thanks
Her face is very nice
Many thanks
wow she looks awesome excellent job


text:
Klingon WOTD: 'oDwI' (noun)
Expand Messages
- This is the Klingon Word Of The Day for Saturday, September 1, 2007.
Category: People
Klingon word: 'oDwI'
Part of Speech: noun
Definition: arbitrator
Source: KGT (232 KE, 234 EK)
Swedish: medlare
The Klingon Word Of The Day is brought to you by Holtej (speersd@...). Please contact me with additions, corrections or comments.
--Holtej 'utlh
Your message has been successfully submitted and would be delivered to recipients shortly.


text:
Murder by the Book - Houston, We Have Carriger!
That said, these days, there is some nonsense with domestic travel where the slightest turbulence now confines all to their seats. It never used to be this way. Nothing angers me more than decreased liberty due to increased safety measures probably the result of some lawsuit or another but the actual consequence of which is to make respectable grown adults feel like either infants or cattle. Possibly both.
(Or more precisely, Houston we have Papillon)
Arrived in Houston safe and sound, caught Taxi to hotel, changed into dress, and got the Hotel to shuttle me to the bookstore across the freeway. Strange to find an enclave of "my folks" in this part of the world, but that is defiantly what the Murder by the Book people were. I was instantly shepherded off to sign books in the back, the Jaye arrived, and then Nicole.
We had a brief discussion and elected not to do readings but just to do a Q&A session. Then we snaked out and took our seats in front of thousands. (Well, like 40 or so, but definitely my biggest event so far.) It was great! People asked some wonderful questions, we had a wide range of responses. Then everyone lined up according to number, very politely, and I signed books.
I got to meet peeps from facebook and twitter. It was so exciting ~ my own little Hadron Collider: cyberspace reality and physical reality crashing into each other! There were many photos shot and "wait, I know that name!" discoveries and that kind of thing. I wish I had had time to sit down and have tea and a proper chat with each and every person I talked too. If there is a next time perhaps we can start earlier have a social salon afterworlds.
Then the girls and I went out on the town. I ate my bodyweight in crayfish and generally had a wonderful time. My resounding impression of Houston was that the cars are very big, and the seats are large and rather low. Returned to the hotel, slept like a dead thing, flew back to Cali. Ah the jet setting life (it's hell on the skin I tell you but wonderful on the pallet).
Gail's Daily Dose
Your Infusion of Cute:
Chairs of cool!
Your Tisane of Smart:
Make your own fabric at Spoonflower.com ~ so awesome! Someone did steampunk octopus!
Your Writerly Tinctures:
The future of the publishing industry debated in the New Yorker
Marion says, "I have been enjoying every second of it, from the moment it started until the very last page."
SPOILER ALERT! Changeless blurb gives away ending of Soulless. Chasing Ray is pleased, "So, I liked it again. It made me laugh and I find myself enjoying Alexia more and more. To me the dialogue and descriptions and the no small amount of over-the-topness is all part of what makes this series a solid romp."
Out September 1, 2010! Even bigger SPOILER ALERT! Really, DON'T READ THE BLURB ON AMAZON if you haven't read the other books first.
Super Secret Project H: Time to start writing the beast.
Super Secret Project F: Revised first three chapters, waiting on beta.
CAKE in Space: Trunked.
VanderMeer's have announced the table of contents.
Turned in.
Quote of the Day:
"The English are feeling the pinch in relation to recent terrorist threats and have raised their security level from "Miffed" to "Peeved." Soon, though, security levels may be raised yet again to "Irritated" or even "A Bit Cross." The English have not been "A Bit Cross" since the blitz in 1940 when tea supplies all but ran out. Terrorists have been re-categorized from "Tiresome" to a "Bloody Nuisance." The last time the British issued a "Bloody Nuisance" warning level was during the great fire of 1666."
~ Email forward


text:
'Gamepad Only Servers' and Cross-Platform
The title is pretty self explanatory but to further iterate what i mean and why it is important, ill explain...
The whole point in cross-platform is to connect people! most people cant afford to buy more than 1 platform because they all cost around £400-£500 (including PC) so one is enough and most people will only buy one, not everyone is rich. The same goes for buying copy's of the game on said platform, especially since it costs like £50 per platform these days, not to mention DLC.
As a result of most people not being loaded with cash, it can become a nightmare to find out that half your friends bought the PS4, a quarter bought the PC/SteamMachine and the other quarter the XboxOne. Therefore you are limited to a separate private network, to who you can play with and how many friends you can play with at once.
In my experience, when talking about purchasing multiplayer games... the Best Selling point to me is, "how many of my friends bought the game?"
Gamer's are alot more social these days, gaming can be used as a very powerful medium to socialize even more so than chat boxes alone, as you have a 3D character in a 3D multiplayer space, it gives the players a sense of presence, which allows them to PLAY or be Playful in nature in ways that are not possible on facebook... So anyway, the option to connect to everyone would be a massive selling point to the game, if nobody no longer has to worry about what platform they are on, I swear hands down more people will buy this game.
'Gamepad Only Servers' is an idea i thought of, to pretty much blur the line between consoles and PC even further.
The way this could work, is there could be a filters on the server browser or matchmaker called 'Gamepad Only' or if that doesn't go to your taste, we could have little gamepad icon's for PS4,XboxOne,PS3,Xbox360 not that these gamepads have any real advantage over the other. When you join a 'Gamepad Only Server' on PC... vital keyboard and mouse buttons such as 'W' 'A' 'S' 'D' etc. could be temporarily un-binded... in the same way when on CounterStrike: Source, you can type in the console UnbindAll.
'Keyboard + Mouse with Gamepad Servers' could still exist except auto-aim/aim-assist should be turned off perhaps if the Gamepad users have a slight un-natural advantage over the KB+M users.
'KB+M with Gamepad Servers' could also exist on consoles, since you'll be programming the binds for KB+M for PC, why not port this information to consoles? and give them a taster of what KB+M is like, most people own a USB mouse and keyboard so why not.
If Cross-Platform cannot be achieved on all 3 platforms Xbox, Playstation, Steam... then we should still have 'Gamepad Only Servers' on PC since this will mean there are no differences between each platform, meaning people would be more inclined to buy to game if they prefer or just like gamepads but own a PC.
Local Split-Screen Multiplayer could easily be integrated into this Idea. Especially with 'Gamepad Only Servers', Split-Screen with Online! would be a brilliant selling point for the PC version, Split-Screen should never have been removed from the COD series on PC in the first place, because of technical limitations being far less depending on your hardware. Don't forget 4K TV's and Displays can only be used with PC, another reason why Split-Screen is so much better for PC.
As for framerate differences in cross-platform... COD on consoles runs at 60FPS anyway which is super nice, so it really is not that much of an advantage to have 120FPS on PC, it does seem smoother, however it is a minority of people that own 120hz monitors so most people on PC will be running 60hz anyway.


text:
- 75Promote
Art Print
Untitledby Thomas Eppolito
Collect your choice of gallery quality Giclée, or fine art prints custom trimmed by hand in a variety of sizes with a white border for framing.
great reflections :)
Love the reflective quality!
Thanks everyone!
beautiful reflections & tones
Wonderful ✯ ✯ ✯ ✯ ✯ 👍
Thank you, Suz and Wayne!
Wow, beautiful!
Thanks you Tara & CMcDonald!
Thank you Nzinga.Mbandi!
Great capture
Thank you, Yasmina!
Wonderful shot Thomas!
Appreciate it, thank you!
Great capture, Thomas!
Great art!
Thank you, Amy & Angelo!
Nice shot!
Thank you, Pom graphic design!
great! greatest!!!
See More Comments


text:
iHerb Customer Reviews
Huge pills!
3 people found the following review helpful
Posted by Reviewer2617093 on Apr 28, 2011
I rated four stars because I couldn't take them after discovering how big the pills were! I gave them to a body builder friend of mine who seems to love them.
2 people found the following review helpful
Posted by jacked on Jul 11, 2012
Broke down and decided to try the Animal Pak finally.. I took Animal Pak while on "cycle" so I used 2 packs per day vs 1 pack in regular training situations.. When putting a heavy load on your body such as on a cycle it's nice to read the ingredients of Animal Pak and know that the deficiencies caused by the stress load is being replenished by one source.. If you hate taking pills don't bother with Animal Pak, 11 pills is a lot for a "Multi-vitamin" but you are getting evrything you need to fully harness the gains you are trying to achieve.. Yeah some pills taste that earthy vitamin taste but over all there was complete ease with taking these pills and not much after taste (which I have had with other multi's) Overall I feel more comfortable taking Animal pak, vs trying to make up for what a 1 pill Multi-vitamin is lacking, and when you break it down the cost is actually easier to grasp..
1 person found the following review helpful
Posted by Reviewer1475315 on Apr 03, 2011
Very happy with the customer service, was quick and fast, great product also.
1 person found the following review helpful
Posted by Reviewer2982870 on Sep 14, 2011
one of the better pre-workout
A bunch of pills
Posted by Reviewer1635472 on Nov 02, 2011
So many pills, probably best to spread out throughout the day. It's pretty handy their packed in sets.


text:
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Winter forest scenery processed with smooth gradient rainbow colors. Starting with blue to represent the coldness of winter then gradually changing to orange to symbolize the approaching warmth of spring. A more positive view of winter as a time of transition for better things to come
In the spirit of always lagging 2 steps behind, I would like to dedicate this to Eve Livesey as a belated birthday present She took the original photo, I just manipulated the colors and tones.
As a gift, I am exceptionally releasing this image for free at full resolution with the same Creative Commons License I use for all my other stock.
Très doux, en effet, et superbe.
That looks really cool.
Awww thank you Nick - wonderful present


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7 posts tagged with factory and China.
Displaying 1 through 7 of 7. Subscribe:
The iEconomy
The iEconomy: Apple and Technology Manufacturing. Since January, the New York Times has been running a series of articles "examining the challenges posed by increasingly globalized high-tech industries," with a focus on Apple's business practices. The seventh article in the series was published today: In Technology Wars, Using the Patent as a Sword. Related: For Software, Cracks in the Patent System and Fighters in the Patent War. [more inside]
smaller companies are using robots
Made in America: small businesses buck the offshoring trend - "For US manufacturing to make sense, factories must make extensive use of automation. That's getting easier, given that the cost of robots with comparable capabilities has decreased precipitously in the past two decades." [more inside]
a day in the life
He might've placed a couple of chips into your Mac, Dell or Hewlett-Packard. Meet Yuan Yandong.
"They actually envied those who could take a leave due to work injury, while casually joking about how their station's been toxicated."
A (translated) Chinese report on life as a factory worker at Foxconn, the company that manufactures iPhones and other gadgets. Each employee would sign a "voluntary overtime affidavit," in order to waive the 36-hour legal limit on your monthly overtime hours. This isn't a bad thing, though, as many workers think that only factories that offer more overtime are "good factories," because "without overtime, you can hardly make a living."
"Seiri, Seiton, Seisō, Seiketsu, Shitsuke and Safety"
The National Labor Committee, a watchdog group that investigates working conditions at foreign factories producing goods for US corporations, has released a report on the KYE Factory in Guangdong, China. KYE manufactures outsourced products for Microsoft (their biggest customer), HP, Best Buy, Samsung, Foxconn, Acer, Logitech, and ASUS. The report focuses heavily on the workers producing Microsoft products. In response, Microsoft says they will investigate the allegations, as their vendor code of conduct (pdf) bans much of the abuses uncovered by the report. Photo Slideshow / NLC report summary [more inside]
Workshop of the world
Health and safety issues at an 'investment casting' (AKA 'lost wax') factory near Ningbo. Seventh in a series of photo essays (1 2 3 4 5 6) by Hong Kong-based independent photographer Alex Hofford, looking at life and work in the factories of southern China where the world's stuff gets made.
A Toy Factory in China.
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My mother always told me I'd make something of myself. I hope she won't be too disappointed to learn that the new film starring Ben Stiller, "Greenberg,"... More.
A painful decade in Jewish history
December 28, 2009 | 4:42 pm
It's that time when most journalism outlets are reflecting on the biggest stories of the past year and decade. And over the next few days I'll be linking to a... More.


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The Red Sox re-called right handed pitcher Steven Wright from Triple-A Pawtucket and designated outfielder Corey Brown for assignment.
Wright was last up in the majors Aug. 3 but did not play in the game. He's a knuckleballer who has gone 6-3 with a 2.81 ERA over 14 starts between Pawtucket (13 starts) and Double-A Portland (1 start).
Brown, 28, played in three games for the Sox since being called up Aug. 5. He went hitless in each of his at bats. He has played in 39 major league games in his career.


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April 5, 2014
Primer: Wisconsin vs. Kentucky
Follow @miller_zack
ARLINGTON, Texas - Bo Ryan and John Calipari have never faced off against each other, but Kentucky holds a 3-1 all-time advantage over Wisconsin. All of that is thrown out the window tonight, however, as the two teams will face off in the Final Four with the winner advancing to the championship game on Monday and the loser going back to school.
Below are lineups, notes and vitals for tonight's matchup.
Game Info
When and Where: 7:49 p.m. (CT) Saturday at AT&T Stadium
Radio: 1310 AM, 101.5 FM
Coach: Bo Ryan, 321-120 in his 13th season at Wisconsin.
Probable starters (height, year, ppg.)
1 Ben Brust 6-1 Sr. 12.8
12 Traevon Jackson 6-2 Jr. 10.7
15 Sam Dekker 6-7 So. 12.4
21 Josh Gasser 6-3 Jr. 8.9
44 Frank Kaminsky 7-0 Jr. 14.1
Key reserves (height, year, ppg.)
10 Nigel Hayes 6-7 Fr. 7.8
13 Duje Dukan 6-9 Jr. 2.7
24 Bronson Koenig 6-3 Fr. 3.3
Quick hits: This is Wisconsin's first Final Four since 2000. Wisconsin has not been to a National Championship game since 1941 Wisconsin is 29-18 all-time in the NCAA Tournament Since 1979, the Badgers are 5-1 as the No. 2 seed in the NCAA Tournament and are 1-2 against No. 8 seeds. The Badgers are 19-8 in the NCAA Tournament as the higher seed Wisconsin is averaging 73.2 points per game in the NCAA Tournament, second to UConn (76.8) among the Final Four, while allowing 56.8 points per game, second to Florida (55.0) among the Final Four Frank Kaminsky averaged 18.5 points, 6.0 rebounds and 1.75 blocks per game through the first four games of the NCAA Tournament Traevon Jackson is 17-for-19 (.895) from the free-throw line so far in the tournament. He has a team-high 2.0 assist-to-turnover ratio.
Coach: John Calipari, 151-36 in his fifth season at Kentucky.
Probable starters (height, year, ppg.)
1 James Young 6-6 Fr. 14.1
2 Aaron Harrison 6-6 Fr. 14.1
5 Andrew Harrison 6-6 Fr. 11.0
30 Julius Randle 6-9 Fr. 15.1
44 Dakari Johnson 7-0 Fr. 5.1
Key reserves (height, year, ppg.)
00 Marcus Lee 6-9 Fr. 2.4
22 Alex Poythress 6-8 So. 5.8
25 Dominique Hawkins 6-0 Fr. 0.7
Quick hits: Kentucky is 115-46 all-time in the NCAA Tournament, the most wins of any team in the country Under John Calipari, the Wildcats are 17-2 in the NCAA Tournament Kentucky has the most NCAA Tournament wins of any school since 2010 with 17 Kentucky became the first school to win an Elite 8 game with five freshman starters since Michigan in 1992 Aaron Harrison has scored in double-digits in every postseason game this season including the SEC Tournament. He is averaging 16.6 points per game and is shooting 50 percent from three-point range Willie Cauley-Stein is listed as doubtful with an ankle injury.
Why you should worry: In nine NCAA Tournaments since 2004, John Calipari has not lost to a seed lower than No. 3.
Why you shouldn't worry: The Badgers are a perfect 17-0 against teams outside of the Big Ten this season.
For more Wisconsin Badgers news, notes and discussion, follow Zack on Twitter.


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ProportionatelyPonderousParasites Proportionately Ponderous Parasites YKTTW Discussion
|Proportionately Ponderous Parasites
The parasites of giant creatures are also giant.Needs Examples Better Name
When there are monstrously large creatures roaming the country side, you can expect the things that live on them (be they parasitic or symbiotic) to be proportionally as large. The creepiest of Big Creepy-Crawlies. They may be annoyances for their host, but for humans, they can be deadly. Often they are often more monstrous or mutated just to be able to live on such gigantic life forms. Keep in mind that some parasites can get pretty large within human hosts (tape worms, etc.). This trope is for parasites that are larger than their normal (read: human and common animal preying) brethren due primarily to their host organism being larger. A common feature of a Womb Level and often featured living on Kaiju.
ExamplesComic Books
- The comic book Godzilla Legends has Godzilla, again, afflicted with a parasite. This time, it's a bird making a nest amidst its spines. The radioactivity mutated the birds into razor-beaked, multi-eyed freaks.
- Pacific Rim. This has the some of the smallest parasites -- they look like Isopods, but are the size of footballs.
- The Return Of Godzilla. In 1984 started this trope in modern times possibly. Here, Godzilla is aflicted with 4 to 5ft long sea lice. They are called Shokilas.
- Gojira. A possible example. Inside Godzilla's footprint on Odo Island, Doctor Yamane discovers a Trilobite that, presumably, was living on Godzilla as a parasite. This one is the smallest known, at 6 inches.
- Cloverfield. Clover has extremely dangerous "Flea" like creatures living on its hide. Their bite is extremely dangerous. They're about 5ft long to boot.
- Chrono Trigger's Lavos is nothing more than a giant mite from outer space, which also happens to suck planets dry and is capable of raining fiery death on an entire world.
Replies: 19


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IT Services
Company Overview of Compliance Data Center LLC
Company Overview
Compliance Data Center LLC operates and maintains computerized online data base of individuals, businesses, corporations, and other entities who fail to fulfill their brokerage obligations, or who involve with legal issues concerning fraud, money laundering, securities violations, or complaints. The company also provides a direct Web-based data entry system for its subscribers. It serves securities and banking industries. The company was founded in 1962 and is based in New York, New York. Compliance Data Center LLC operates as a subsidiary of Equifax Information Services LLC.
62 William Street
New York, NY 10005-1520
United States
Founded in 1962
Key Executives for Compliance Data Center LLC
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This week, Wells Fargo and American Express launched Propel 365 and Propel World, two new credit cards for Wells Fargo customers that are accepted on the American Express global merchant network.
Henry Wells and William Fargo were founders of American Express in 1850, and founded Wells, Fargo and Company separately in 1852 to bring express and banking services to gold rush pioneers. Wells Fargo and American Express were competitors in the express business—transferring and shipping customers' money and valuable goods by the fastest means available. But the two companies also had several people work for both companies, often simultaneously. The two express companies also had several products in common.
Reciprocity increased efficiency regardless of territory. In the beginning, Wells Fargo express connected with American Express and other companies in the east. In 1882, American Express introduced its own money orders, a financial product to compete with postal money orders. American Express made arrangements with Wells Fargo for payment of these money orders in eleven western states and territories, and in Mexico.
Wells Fargo introduced its own brand of express money orders in 1885, and sold a half-million of them in the first year (a $7.5 million-dollar business). Wells Fargo money orders coincided with the rise of the mail order goods business, making reliable payment accessible to even novice consumers. Wells Fargo and other express companies delivered much of the mail order goods of Chicago retail giants Montgomery Ward, and Sears, Roebuck & Co.
American Express offered the innovative traveler's cheque in 1891. Wells Fargo & Co's Express offered the instrument under its own name in 1903.
The two companies found synergies too beyond similar interests in products and services. They swapped office space, barns and stables, and even bought wagon horses from the same supplier in Chicago in 1897. Contracts for carrying express on various railroads were negotiated and changed hands between Wells Fargo, American Express and other express companies on a regular basis, bringing each company in and out of market and service areas.
Company baseball teams squared off against each other in friendly family rivalry as well, and in 1906 the two took their competitions into a whole new field: football. Wells Fargo and American Express squads faced off in Jamestown, New York in 1906. AmEx won 5 to 0.
In 1914, the American Express, Wells Fargo and Adams Express companies established a Bureau of Public Relations in New York City. Likely publicity manager Louis M. Porter dealt with issues of mutual interest to the expressing industry, including increasing regulation.
The federal government took over the nation's express operators as a wartime measure in 1918. Both American Express and Wells Fargo faced a radically changed business model. American Express sustained its successful travelers cheque business. Wells Fargo & Co.'s Express, though, went from over 10,000 express offices to none, overnight. The Wells Fargo name continued in the banking business in San Francisco.
Wells Fargo's bank and express company remained intertwined through complicated stock holdings for several decades, but the separation gradually became complete. The express continued with limited operations in Mexico and Cuba, in which American Express acquired a majority interest in 1919. American Express acquired 100% of what remained of the former Wells Fargo & Company in 1963, which by then was primarily the armored car and security business.
Wells Fargo and American Express have had intersecting business (and people) since 1852. With Propel 365 and Propel World, our long history continues to take shape.


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Rangers announcerwins Frick Award
LAKE BUENA VISTA, Fla. Texas Rangers announcer Eric Nadel won the Ford C. Frick Award for excellence in baseball broadcasting.
Im so excited, Nadel said during a conference call Wednesday. Im happy, tremendously flattered. Its an amazing thrill for a kid from Brooklyn, who grew up as a radio junkie. Im still a radio junkie, I guess.
The award was announced by the baseball Hall of Fame at the winter meetings.
Nadel has been with Texas for the past 35 years. For the last 19, he has been the lead voice on Rangers radio broadcasts.
Former President George W. Bush, a former Rangers owner, has fond memories of listening to Nadel, whom he called a friend.
His passion for the sport is evident in every broadcast, Bush said in a statement issued through the Rangers. Any announcer can call a game, but Eric brings his listeners into the stadium. He is a wonderful ambassador for our national pastime.
The 62-year-old Nadel called Nolan Ryans 5,000th strikeout on Aug. 22, 1989, and was on air for the Rangers six playoff berths and two American League pennants.
His signature home run call, That ball is history! is part of Rangers lore.
Erics description and analysis of thousands of Texas Rangers games over the last 35 years have been a joy for the fans, Hall of Famer Nolan Ryan said through the Rangers. He has always made the games entertaining and informative. He is a Hall of Famer in every sense of the word and is very deserving of the honor.
Nadel will be honored during the Hall of Fame awards presentation July 26 in Cooperstown, N.Y.MORE IN Sports Wire
BOSTON — The Boston Celtics enjoyed a season-high scoring day to keep their current... Full Story
SAN FRANCISCO — Cam Newton is now a Super Bowl quarterback with an MVP award. Full Story
MONTREAL — Ben Scrivens made big saves all weekend, helping the Montreal Canadiens to a... Full Story
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Welcome to Work Boots & More
We sell at Below Suggested Retail Price! At Work Boots & More, we have a great selection of shoes and sandals. We also carry Browning and Rocky clothing, including cool shirts, warm jackets, and sweatshirts. Then we have accessories, including top-quality belts, socks, and wallets.


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"Hey, I thought we were going to see the movie tonight?" I asked my girl friend. As we drove past the theater in town. We had been going out for about three months now and she and I hadn't done anything all that serious yet.
"Well we
"Hey, I thought we were going to see the movie tonight?" I asked my girl friend. As we drove past the theater in town. We had been going out for about three months now and she and I hadn't done anything all that serious yet.
"Well we
Dan had a trial in the morning. He had to figure out how to defend some stupid kid who broke into an old woman's apartment and then got conked over the head with a frying pan. But it might as well have been him on trial, sitting in that chair next
My first time took place this past Halloween. The story starts at my best friends Halloween party. Me and my boyfriend, Ben, were sitting on the couch very close watching 'Scream' with about 10 other people. My costume was Pippi Longstockings, whi
Silence was Sarah's only companion as she sat in the passenger seat of the car. She was waiting, in front of the motel's reception, for her boyfriend to return with the room key. It was the night of their formal and although it had been over fo
I work in a funeral home in a large city and it is a little depressing to see the amount of young people who come through here, not just teenagers but twenty and thirty something some mothers, some fathers, brothers, sisters its sad. Sad because the
It was that time again for Johnson Hall's tradition of fox hunting. Every year, all the freshman at this SUNY Oswego school get together at sundown and go out for a night "hunt". The hall was divided into groups of black and white.
My lady please remove all of your clothing and fold it neatly and place it on the chair. Please lay face down on the bed facing the window so u can see the beautiful sunrise. Placing a large hot bath sheet made of cotton over you from your shoulde
"Heat of the Moment"
You can take this as just a story if you choose, but I will tell you that it is not, I have not even changed the names of those of us involved.
My wife and I were just sitting at home on our couch, my wife ,Dana
"AAAAAAAAHHHHHHHHHHHHHHHHHHHHH!!!" Cathy screamed her lungs out as soon as she felt her cherry pop. Blood began to spill out of her pussy and created a pool on the floor. Teresa ignored all of this and just pulled her strap-on out a bit, then thru
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From the balcony Elizabeth had a perfect view of the ball. The women in their dresses twirled and fluttered like flower petals. But of course Elizabeth did not care. All she could think about was Manuel. He was below her dancing with Henry Taylor
Hello! This story tells how my love relationship started with my mom. But I should propably start by telling about me and mom. Well, I have dark hair, wich I keep short, brown eyes, OK looks and about 10 inch long dick. My mom ha
Why I stayed in the Forest
Hi! I'm John. This tells the reason why I stayed on a mountain. But let me tell you more about myself. I'm 50 years old now, but when this happened I was 30. I had the worlds biggest cock. I was thought as a freak. T
Mute kid
Hi! I'm the mute kid. You most likely understand why I'm called like that. Yes, I'm a mute. It's not fun at all. Everybody calls me a Mute Kid. But one time it brought a nice situation for me. That's what I'm going to tell you about.
"Hi daddy, I just got home. Hope you don't mind, but I brought Taylor with me. She said that she wanted to meet you because you look good and she likes the way I talk about my daddy."
"Just what did you tell her Autumn?" "Well, I told her t
The night was set. It was suppose to be a surprise for his girlfriend. She knew it was coming but not sure when. He picked up his girl for a birthday dinner, she was wearing a black form fitting dress that her friend got her for her birthday. Little
I was 17 the first time I had sex. Lee and I had been dating for about 7 months and all we had done was oral sex. He was the sexiest guy I'd ever met. He was about 6'2, 165 lbs,a baseball player. We were in our junior year of high school. We were
Happy Birthday by Screw3 copywrite 9/15/2004
Marge Sandowski opened the door. "Welcome Mark, I promised you an 18th birthday present and today is the day. Denise has gone out so please come in."
Mark came in and followed his girl friend
Evan was 44 and a normal average nerd businessman, spent most of his time working or at home with his kids and wife. That is until they grew up and she grew to love pain pills and being without him more. So after several years of loneliness and bor