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Publications (19)3.99 Total impact
Article: [Advances in the research of the biological activities of degradation products of extracellular matrix][Show abstract] [Hide abstract]
ABSTRACT: ECM is a supporting structure for stabilizing the location of cells and preserving the structure of tissues. Recently, it has been discovered that ECM and its degradation products may exert profound influences on tissues and cells, such as activities of inflammatory cells and immune cells. Angiogenesis may be stimulated or inhibited by degradation products of ECM. Matrikines, liberated by partial proteolysis of ECM macromolecules, are found to regulate cell functional activities and play a significant role in wound healing or tumor invasion. Post-burn denatured dermal matrix is being studied in burn healing now. The study of post-burn denatured or necrotic dermal matrix should be emphasized in future.
Article: Construction of keratinocyte growth factor phage active peptides for the promotion of epidermal cell proliferation[Show abstract] [Hide abstract]
ABSTRACT: To construct and display the keratinocyte growth factor (KGF) phage active peptides so as to detect the promoting effects of epidermal cell. KGF sequences were chosen and their primers were designed. The selected genes of P1, P2 and P4 were obtained by reverse transcription (RT)-PCR. P3 was obtained by direct synthesis. And the KGF genes were subcloned into pComb3 vector. The technique of phage display was employed to display the genes on phage surface. Methyl thiazolyl tetrazolium (MTT) assay was used to evaluate the promoting effects of KGF phage active peptides on the proliferation of epidermal cell. Optical density (A) was determined at 570 nm. Immunofluorescent assay was employed to evaluate the cell affinity of KGF phage active peptides. The four KGF genes were obtained and subcloned into pComb3 vector. The proteins of the KGF genes were expressed on the surface of the pComb3 vector. The MTT data of optical density (A) showed that significant differences existed between the negative control and KGF control (0.293 ± 0.017 vs 0.520 ± 0.043) and KGF phage active peptide groups (0.293 ± 0.017 vs 0.469 ± 0.057, 0.441 ± 0.048, 0.438 ± 0.035, 0.446 ± 0.037) (all P < 0.01). The results of immunofluorescent assay indicated that KGF and KGF phage active peptides had excellent cell affinity. KGF phage active peptides are successfully constructed and displayed and they may promote the proliferation of epidermal cell.
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ABSTRACT: To explore the feasibility of burn denatured acellular dermal matrix (DADM) as dermal substitute in repairing wounds. (1) Nine Wistar rats received a deep partial-thickness scald on the back. Full-thickness wounded skin was collected on post scald day (PBD) 1, 2, and 3 (with 3 rats at each time point), and it was treated with 2.5 g/L trypsin/0.5% Triton X-100 to remove cells to prepare DADM, respectively called DADM-1 d, DADM-2 d, and DADM-3 d. Another 3 rats without scald injury were treated with the same method as above to prepare acellular dermal matrix (ADM) to serve as control. Gross and histological observations and microbiological and biomechanical tests, including ultimate tensile strength, maximum tension, stretched length at breaking, stress-strain relationship, were conducted for the resulting ADM and DADM. (2) Another 64 rats were divided into ADM group and DADM-1 d, DADM-2 d, and DADM-3 d groups according to the random number table, with 16 rats in each group. A skin flap in size of 2.0 cm×1.8 cm was raised on the back of each rat. The above-mentioned ADM, DADM-1 d, DADM-2 d, and DADM-3 d were cut into pieces in the size of 1.8 cm×1.5 cm, and they were respectively implanted under the skin flaps of rats in corresponding group. At post surgery week (PSW) 1, 3, 5, or 9, 4 rats in each group were used to observe wound healing condition and change in implants with naked eye, and histological observation of the implants was conducted. Data were processed with one-way analysis of variance and t test. (1) The freshly prepared DADM was milky white, soft in texture with flexibility, but poor in elasticity as compared with ADM. No epithelial structure or cellular component was observed in ADM or DADM under light microscope. Collagen fibers of DADM were seen to be thickened unevenly and arranged in disorder and eosinophilic. All microbiological results of DADM were negative. There was no statistically significant difference among DADM-1 d, DADM-2 d, and DADM-3 d in levels of ultimate tensile strength, maximum tension, stretched length at breaking, and stress-strain relationship (with F values from 0.088 to 3.591, P values all above 0.05). Values of the above-mentioned four indexes were the highest in DADM-3 d, they were respectively (13.0 ± 2.4) MPa, (61 ± 4) N, (173 ± 7)%, (45.7 ± 2.0)%. Values of the four indexes of ADM were respectively (19.0 ± 2.6) MPa, (95 ± 4) N, (201 ± 5)%, (62.5 ± 2.2)%, which were higher than those of DADM-1 d, DADM-2 d, and DADM-3 d (with t values from 6.424 to 17.125, P values all below 0.01). (2) No exudate or swelling in the wounds of rats, and no contraction or curling of implants were observed in every group at PSW 1, but inflammatory cells infiltration and Fbs inward migration were observed in the wound. At PSW 3, the growth of hair was normal in the wound in DADM-1 d, DADM-2 d, and ADM groups, but few and scattered hair grew in DADM-3 d group. The inflammatory cells decreased, while Fbs increased, and new capillaries were found to grow inwardly in each group. The decrease in inflammatory cells was slightly delayed in DADM-3 d group. At PSW 5, hair growth became normal, and implants shrank and thinned with fiber membrane wrapped densely and bundles of ingrowing large caliber blood vessels in all groups. The dermal matrix in each group merged with the surrounding normal tissue. At PSW 9, ADM and DADM became white, thin, and soft tissue sheet which was closely connected with the inner side of the flap. There was no infiltration of inflammatory cells in implants in either group. The collagen fibers arranged regularly and densely, and they were integrated with normal collagen tissue. The burned DADM does not have obvious immunogenicity, but with good biocompatibility. It is prospective to become as a dermal substitute in repairing wounds.
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ABSTRACT: To isolate the transforming growth factor-beta 1 (TGF-β1) phage model peptides from phage 12-mer display peptide library to inhibit the proliferation of keloid fibroblasts. The phage display 12-mer peptide library was screened for 4 rounds with monoclonal anti-human TGF-β1 as the target to yield the specific phage model peptides. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used for the quantitative determination of cellular proliferation. Apoptosis was detected by the Annexin V-FITC/PI apoptosis detection kit and the cells were analyzed with flow cytometry. Immunofluorescent assay was employed to show the binding affinity of model peptides for keloid fibroblasts. Quantitative real-time polymerase chain reaction (PCR) was performed to detect the expressions of nuclear factor kappa B (NF-κB) and connective tissue growth factor (CTGF). Ten phage model peptides were obtained and they were similar to TGF-β1, TGF-β2, TGF-β receptor II (TβRII), TGF-β-induced factor, NF-κB or mitogen-activated protein kinase (MAPK). The results of MTT showed that four phage model peptides (No. 7 - 10) could inhibit the proliferation of keloid fibroblasts (P < 0.05). The results of apoptotic assessment showed that phage model peptides (No. 7 - 10) could slightly trigger the late apoptotic stage of keloid fibroblasts. The data of immunofluorescence assay revealed that the model peptides on phages rather than phages could bind to keloid fibroblasts. The findings of quantitative real-time PCR analysis suggested that the relative expression of NF-κB decreased in phage model peptides groups (No. 7 - 10). The quantitative expression was 0.28, 0.26, 0.46 and 0.30 respectively versus the negative control group. The relative expression of CTGF decreased in phage model peptides groups (No. 7 - 10). The quantitative expression was 0.26, 0.60, 0.34 and 0.17 respectively versus the negative control group. Four phage model peptides (No. 7 - 10) isolated from phage display 12-mer peptide library can inhibit the proliferation of keloid fibroblasts via regulating the expressions of NF-κB and CTGF.
Article: Transforming growth factor-β1 phage model peptides isolated from a phage display 7-mer peptide library can inhibit[Show abstract] [Hide abstract]
ABSTRACT: Transforming growth factor-β1 (TGF-β1) is known to have a role in keloid formation through the activation of fibroblasts and the acceleration of collagen deposition. The objective of this current study was to isolate TGF-β1 phage model peptides from a phage display 7-mer peptide library to evaluate their therapeutic effect on inhibiting the activity of keloid fibroblasts. A phage display 7-mer peptide library was screened using monoclonal anti-human TGF-β1 as the target to obtain specific phages containing ectogenous model peptides similar to TGF-β1. Enzyme-linked immunosorbent assay (ELISA) was performed to select monoclonal phages with good binding activity, which underwent DNA sequencing. MTT assay and apoptosis assessment were used to evaluate the biological effects of the phage model peptides on keloid fibroblasts. Immunofluorescence assay was employed to show the binding affinity of the model peptides on phages causing keloid fibroblasts. Quantitative real-time PCR analysis was carried out to detect the expressions of nuclear factor κB (NF-κB) mRNA, connective tissue growth factor (CTGF) mRNA and TGF-β receptor II (TβRII) mRNA in keloid fibroblasts. Specific phages with good results of ELISA were beneficiated. Four phage model peptides were obtained. The data of MTT showed that TGF-β1 and one phage model peptide (No. 4) could promote keloid fibroblasts proliferation, however, three phage model peptides (No. 1 - 3) could inhibit keloid fibroblasts proliferation. The results of apoptosis assessment showed that the three phage model peptides could slightly induce the apoptosis in keloid fibroblasts. The data of immunofluorescence assay revealed that the model peptides on phages rather than phages could bind to keloid fibroblasts. The findings of quantitative real-time PCR analysis suggested that the expressions of NF-κB mRNA and CTGF mRNA in the three phage model peptide groups decreased, while the expression of TβRII mRNA slightly increased. Three phage model peptides isolated from a phage display 7-mer peptide library can inhibit keloid fibroblasts proliferation and induce the apoptosis in keloid fibroblasts. They can inhibit the activity of keloid fibroblasts by blocking TGF-β1 binding to its receptor and then regulating the expressions of NF-κB, CTGF and TβRII.
Article: Keratinocyte growth factor phage model peptides can promote epidermal cell proliferation without tumorigenic effect[Show abstract] [Hide abstract]
ABSTRACT: Keratinocyte growth factor (KGF) significantly influences epithelial wound healing. The aim of this study was to isolate KGF phage model peptides from a phage display 7-mer peptide library to evaluate their effect on promoting epidermal cell proliferation. A phage display 7-mer peptide library was screened using monoclonal anti-human KGF antibody as the target. Enzyme linked immunosorbent assay (ELISA) was performed to select monoclonal phages with good binding activity. DNA sequencing was done to find the similarities of model peptides. Three-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, immunofluorescence assay and quantitative real-time PCR analysis were employed to evaluate the effect of the phage model peptides on epidermal cells. Thirty-three out of fifty-eight (56.9%) of the isolated monoclonal phages exhibited high binding activity by ELISA. Ten of fifteen obtained phage model peptides were similar to KGF or epidermal growth factor (EGF). MTT assay data showed that four (No. 1 - 4) of the ten phage model peptides could promote epidermal cell proliferation. The expression of keratinocyte growth factor receptor (KGFR) mRNA in the KGF control group and the two phage model peptide groups (No. 1 and No. 2) increased. Expression of c-Fos mRNA and c-Jun mRNA in the KGF control group increased, but did not increase in the four phage model peptide groups (No.1 - 4). Four phage model peptides isolated from the phage display 7-mer peptide library can safely promote epidermal cell proliferation without tumorigenic effect.
Article: Focal injection of vancomycin combined with surgical debridement-dermatoplasty in the treatment of pseudo-epitheliomatous granuloma[Show abstract] [Hide abstract]
ABSTRACT: Pseudo-epitheliomatous granuloma (PEG) can occur in some small skin wounds with secondary infections resulting from improper treatments. It is difficult to heal and can easily relapse. This study explores the clinical and pathological characteristics of PEG and effective treatments. Tissue specimens of PEG obtained from 11 patients (age range: 2-67 years) were sent for microbial examination and histological observation. The local lesions were treated by focal injection of vancomycin combined with surgical debridement-dermatoplasty. The diagnosis of PEG was based on histological examination, which revealed long epithelial peduncle encapsulated granulation tissue-like honeycomb in which more vessels, macrophages, lymphocytes and mast cells and less extracellular matrix were distributed. Bacteria such as Staphylococcus aureus, Bacillus pyocyaneus, ethylene-type Streptococcus, stool Streptococcus and F-citric acid Bacillus were found in the microbial culture of the specimens. They were tolerant to celbenin but sensitive to vancomycin. PEG could be cured by focal application of vancomycin combined with free skin or skin flap after thorough debridement. The relapse of PEG could be prevented by the therapy. Focal injection of vancomycin combined with surgical debridement-dermatoplasty is an effective therapy for PEG.
Article: The changing pattern of stem cell markers of sweat gland in deep partial-thickness burn wound[Show abstract] [Hide abstract]
ABSTRACT: To investigate the rules of proliferation of epithelial cells of sweat glands in deep partial-thickness burn wound and its transdifferentiation towards epidermal cells during healing process to explore its mechanisms. Twenty-eight patients with limbs and trunk burn hospitalized in the Fourth People's Hospital of Taizhou City of Jiangsu Province and the Second Hospital of Shandong University from January 2004 to December 2007 were enrolled in the study. Tissue samples of deep partial-thickness burn wound (DPBW, n = 37), superficial partial-thickness burn wound (SPBW, n = 21), and normal skin (NS, n = 10) were harvested. Expressions of cytokeratin 10 (CK10), bcl-2, P63, CK14 and CK19 of epithelial cells in glandular secretory portion (GSP) in DPBW, SPBW and NS were detected with immunohistochemical double staining method. In NS, CK19, CK14 and CK10 expressed in medium intensity in GSP epithelial cells, P63 and CK14 weakly expressed in basal myoepithelial cells, while no expression of bcl-2 or P63 was observed in all CK10 positive terminally differentiated cells. In SPBW, no change of the construction of GSP and above-mentioned proteins during healing process was observed. In DPBW, as examined on 7(th) post burn day (PBD), expression of P63 and bcl-2 in GSP epithelial cells was enhanced. In DPBW on 8 - 10 PBD, bcl-2, P63, CK19 and CK14 strongly positive solid island-like epithelial structure was formed by proliferation, migration and squamous epithelization of basal cells. Such structure, along with granulation tissue, migrated towards the superficial layer of wounds. The hyperplasia of squamous epithelium resulted in complete reepithelialization. In DPBW, bcl-2, CK14, CK19 and P63 still strongly expressed in hyper-proliferative epidermal basal and suprabasal layers on 13 - 30 day after healing. During the natural healing process of DPBW, monolayer epithelium (CK19 and CK10 positive) of GSP slowly develops into stratified squamous epithelium (bcl-2, P63, CK19, and CK14 positive), suggesting that the epithelial-epidermal transdifferentiation of GSP undergoes slow retrodifferentiation process of stem cells and transient amplifying cells, resulting in the imbalance between lagged growth of epithelium and the hyperplasia of granulation tissue, constituting one of the important mechanisms of disturbance in DPBW repair.
Article: [The correlation of the fetal cytokeratin expressing in epidermal cells and the different outcomes of wound repairing].[Show abstract] [Hide abstract]
ABSTRACT: To investigate the changing regular of specific cytokeratin (CK) markers expressing in human pseudoepitheliomatous hyperplasia (PEH), keloids (Ke) and hypertrophic scar (HS) lesion, and to explore the correlation between such changes and the different outcomes of wound repair. Histopathology and immunohistochemistry (IHC) double staining methods were used in samples of human PEH, Ke, HS and NS to determine the distribution characteristics and changing regularity of CKs in epidermal tissues. No CK8&18 and CK17 expressed in epidermis of NS group, while CK8&18(+) cells and CK17(+) cells were detected in epidermis of active-stage Ke, HS and PEH. The quantities of CK8&18(+) cells and CK17(+) cells ranked as follows: PEH > Ke > HS and HS > Ke > PEH (P < 0.05). CK19(+) cells and CK5&6(+) cells expressed similar changing trend, while reverse trend of CK10(+) cells was detected in epidermal cells, with local epidermal hyperplasia, cells morphological changes and sub-epidermal inflammatory reaction. Different degree of de-differentiation and terminal differentiation imbalance are found in epidermal cells of active-stage PEH, Ke and HS, which hint the correlation between the abnormal proliferation and differentiation of epidermal cells and the different outcomes of wound repair.
Article: [Relationship between the proliferation and immunoinduction of epithelial cells and the destruction of hair follicles and sebaceous glands in keloids].[Show abstract] [Hide abstract]
ABSTRACT: To investigate the influence of biological behavior of epithelial cells on the hair follicles and sebaceous glands (HFSG) structure in keloids (K). The expression of intercellular adhesion molecule (ICAM)-1, D-related human leucocyte antigen (HLA-DR), and cytokeratin (CK) 14 on epithelial cells and the amount of activity T-lymphocytes were detected in specimens of keloid edge and normal skin with immunohistochemical and histological methods. In comparison with normal skin specimens, epithelial cells were proliferated in K-HFSG presented structural aberration and disintegrate or abnormally to form solid-epithelial island-like structure, and the density of HSFG with hyperplasia and the ageing scar in keloids was apparently decreased. They strongly expressed ICAM-1, HLA-DR, and CK14 in the epithelial cells, there were many immunologic cells which expressed CD4, CD45RO, and interferon (IFN)-gamma around the K-HFSG. The expressed level of epithelial cells was positively correlated with the density of immunologic cells nearby K-HFSG. It could be concluded that the reactivity with hyperplasia and immunoinduction of epithelial cells might be associated with the destruction of the some HFSG structure in the keloids.
Article: [Investigation of mesenchymal-epithelial transdifferentiation in the morphogenesis mechanism of embryonic epidermic cells].[Show abstract] [Hide abstract]
ABSTRACT: To study the relationship between the morphologic mechanism of human embryonic epidermic cells and mesenchymal-epithelial transformation (MET) and its modulation factor. Morphological occurrence of epidermis was detected with histologic methods in earlier period [estimated gestational age (EGA) 6-14 weeks] human embryonic skin samples. At the same time, the characteristic expression and their distribution markers of mesenchymal cells [vimentin and alpha-smooth muscle actin (alpha-SMA)], embryonic specific epidermic protein CK8&18, specific protein of epidermic stem cell CK19, transforming growth factor-beta1) (TGF-beta1) and its receptor (TGFbetaRI) in embryonic epidermis were examined with immunohistochemistry and indirect-immunofluorescent doble-labelling method. During EAG 6-8 weeks, ectodermal cells containing Vim+/alpha-SMA(-) were found to transform into epidermal stem cells with CK8&18+/CK19+. In ectodermal cells, protein expression density of TGFbetaRI was moderate (+ +), while positive signal of TGFbeta1 was weak (+/-). After EGA10 weeks, epidermal cells showed typical morphological characteristics. At EGA 6-8 weeks, human embryonic skin epidermal cells began to form through MET, in which the signal pathway mediated by TGFbetaRI might play important roles, but the role of TGFbeta1 need to be further studied.
Article: [Analysis of etiological factors of pseudo-epitheliomatous granuloma after cutaneous wound healing: a report of 11 cases of patients with this lesion].[Show abstract] [Hide abstract]
ABSTRACT: To explore the pathogenetic mechanism, clinical and pathological characteristics, and prevention and treatment of pseudo-epitheliomatous granuloma after skin wound healing. The clinical information and the treatment results of pseudo-epitheliomatous granuloma occurring in 11 patients (age 1-67 years) were reviewed and analyzed, their tissue specimens were used for microbial examination and histological observation. Some bacteria such as Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus hemolyticus B, and Streptococcus faecalis could be found in the culture of pseudo-epitheliomatous granuloma. The maJority of these bacteria was tolerant to celbenin but sensitive to vancomycin. The lesions were excised, and the wounds were covered with skin grafting or skin flap, supplemented by local of vancomycin to prevent recurrence of the lesion. Histological examination revealed in pseudo-epitheliomatous granuloma with long epithelial peduncle encapsulating granulation tissue like honeycomb, in which there were many capillaries, macrophages, lymphocytes and mast cells, with only a small amount of extracellular matrix. The main pathogenesis of pseudo-epitheliomatous granuloma formation might be improper treatment of wound in earlier period and infection of drug resistant bacteria. Surgical debridement followed by skin coverage and local inJection of vancomycin could be effective and curative.
Article: [Relationship between epithelial-immunologic cells transdifferentiation and pseudoepitheliomatous granuloma lesion].[Show abstract] [Hide abstract]
ABSTRACT: Inappropriate treatment at early stage of wound could result in the formation of pseudoepitheliomatous granuloma (PEG). The correlation of abnormal transdifferentiation of epithelial cells to immunologic cells and the occurrence of PEG lesion was investigated. Morphological change of epithelial tissue was observed with histopathology in 11 specimens of PEG lesions and 6 specimens of normal skins from PEG edge (PEG-N) from 11 patients with damaged skin. The expression characteristics and distribution of pan-cytokeratin (CKp), IV type collagen, laminin (LM), epithelial cadherin (E-Cad), beta-catenin (beta-Cat), focal adhesion kinase (FAK), stem cell factor (SCF) and its receptor-c-Kit, proliferating cell nuclear antigen(PCNA), and cluster of differentiation-14 (CD14), CD68 and mast cell tryptase (MCT) in PEG were detected with the immunohistochemical and the indirect immunofluorescent double-staining. In comparison with PEG-N, epithelial tissue take on squamous metaplasia, and stroma was infiltrated with intensive microvessels and inflammatory cells in the PEG lesion. Poor epithelial basal layer constitution, basal polarization, and migration of basal cells to stroma could be observed. In the ultrastructure, the loose intercellular junction of basal cells and the increased nucleus/cytoplasm ratio and intercellular space could be observed, neonatal monocytoid cells and macrophages and mast cells as a exuviate-like manner brooded from cytoplasm of original epithelial cells and basement membrane. protein expression of CKp and E-Cad by basal cells was significantly decreased, and the IV type collagen and LM protein could not be found in basement membrane of identical locus. By contrast, the immunoreactivity of beta-Cat and FAK was apparently increased. In addition, CD14(+) monocytes, CD68(+) macrophages, MCT(+) mast cells and CD68(+)/MCT(+) cells with various size, and these cells of stronger immuno-staining of SCF, c-Kit and PCNA antigen could be found in epithelial tissue and stroma. Epithelial cells in PEG related to wound are characteristized by transdifferentiation of epithelial cells to immunologic cells, wich may be associated with local infectious and inflammatory reaction, ultimately resulting in enhancement the ratio of beta-Cat/E-Cad signal and activation SCF-c-Kit signal pathway. The phenomena of transdifferentiation epithelial cells in the PEG lesion will help to recognize of the neoplatic immune and trauma repair mechanism.
Article: Gene expression of extracellular-signal regulated protein kinase 5 and their MAPKK in fetal skin hypertrophic scars[Show abstract] [Hide abstract]
ABSTRACT: To explore the change of gene expression of extracellular-signal regulated protein kinase 5 (ERK5) and its upstream signaling molecule (MEK5) in fetal skin of differentially developmental stages and hypertrophic scars. After morphological characteristics of skin of different developmental stages and hypertrophic scars were detected with pathological methods, gene expression of ERK5 and MEK5 was examined with reverse transcription-polymerase chain reaction analysis (RT-PCR). In early gestational fetal skin, genes of ERK5 and MEK5 were strongly expressed, while in late gestational skin and children skin, the expression of ERK5 and MEK5 was apparently decreased (P < 0.05). In normal skin, the level of gene expression of ERK5 was lower. In proliferative hypertrophic scars, mRNA content of this gene was apparently increased. In mature scars, the content of this gene transcript was 3.2 times the normal skin. In contrast, the levels of MEK5 transcript in normal skin and hypertrophic scars of various phases showed no substantial changes (P > 0.05). ERKS medicating signaling pathway might be involved in regulating cutaneous development at the embryonic stage and determining cutaneous structure ad function. The increase of gene transcription of ERK5 and MEK5 in younger fetal skin might be a reason for rapid proliferation of the skin cells and scraless healing of skin. The activation of ERK5 gene expression in hypertrophic scars versus normal skin might be one of the mechanisms controlling the formation of hypertrophic scars, in which the role of MEK5 needed to be further studied.
Article: Jiang DY, Fu XB, Chen W, et al. Relationship of overexpression of angiogenesis factors and their receptors with invasive growth of keloid[Show abstract] [Hide abstract]
ABSTRACT: To study the relationship between invasive growth and the angiogenesis factors and their receptors in keloid. Biopsies from 17 keloid (Ke) were divided into atrophy group (Ke-A, n = 9), proliferating group (Ke-P, n = 13), infiltrating group (Ke-I, n = 9), normal skin around Ke (Ke-N, n = 10) and normal skin (NS, n = 10). The histology, immunohistochemistry and computerized imaging analysis were used for the study. The levels of basic fibroblast growth factor (bFGF) and its receptor-Flg, vascular endothelial growth factor (VEGF) and VEGF/KDR complex (11B5), and platelet derived growth factor (PDGF-A) and its receptor-PDGFR-alpha, and alpha-smooth muscle actin (alpha-SMA) were determined in specimens with immuneohistochemical staining. In all 5 groups, bFGF, Flg, VEGF, 11B5, PDGF-A, and PDGFR-alpha were all expressed in fibroblasts (Fb), monocyte-phagocytes, vascular endothelial cells, adventitial cells, epidermal (cells and epithelial cells in appendage. The intensities of staining ranked as follows: Ke-I > Ke-N approximately equal to Ke-P > Ke-A approximately equal to NS, Flg > hFGF approximately equal to PDGFR-alpha > PDGF-A approximately equal to 11B5 > VEGF (P < 0.05 to approximately 0.01). 11B5 and VEGF were expressed (intensively in alpha-SMA positive myofibroblasts only in Ke-I group. The histological observation showed hyperplasia of endothelial cells and obliteration of microvessels. The invasive growth of keloid may be related to the overexpression of angiogenesis factors and their receptors. The abnormal expression of 11B5 in myofibroblasts may be one of the important factors associated with tumor-like growth feature in the invasive parts sites of keloid. The results suggest that inhibition of these biological activities would be of significance in clinical therapy.
Article: [Expression characteristics of transforming growth factor-beta1 in human skin at different development stages of gestation].[Show abstract] [Hide abstract]
ABSTRACT: To investigate gene expression of transforming growth factor-beta(1) (TGF-beta(1)) and its two upstream signalling factors (smad2 and smad3) in fetal skin at different gestational ages and postnatal skin and its potential biological significance. Fetal skin samples of human embryo were obtained from spontaneous abortions at different gestational ages ranging from 13 to 32 weeks, and also skin collected from patients undergoing plastic surgery. After morphological characteristics of skin at different developmental stages were examined histologically, gene expressions of TGF-beta(1), smad2 and smad3 in skin specimens at different developmental stages were examined with reverse transcription-polymerase chain reaction analysis (RT-PCR). Gene expression of TGF-beta(1), smad2 and smad3 could all be detected in fetal skin and skin after birth. In skin from early gestational fetus, gene expressions of TGF-beta(1) and smad2 were weak. Along with advance in gestational age, gene expression of these two genes in skin became progressively stronger. In skin from late gestational fetus and skin after birth, the transcription contents of these two genes were significantly increased compared with early gestation fetus (P<0.05). On the contrary, gene expression of smad3 was apparently higher in younger fetal skin versus elder compared with that of late fetal skin (P<0.05). In skins after birth, the levels of smad3 gene expression were elevated to the level similar to that in early gestational fetal skin. The signal pathway mediated by TGF-beta(1) might be involved in regulating development of the skin at embryonic stage and in designating cetaceous structure and function, and also in wound healing after birth. The relative lack in expression of TGF-beta(1) and smad2 genes in skins from younger fetuses might contribute to fetal scar-less healing, in which the role of smad3 needs to be further investigated.
Article: [Study of mechanism on loss of some components from basement membrane in epithelial-interstitial junction in cutaneous pseudoepitheliomatous hyperplasia lesion].[Show abstract] [Hide abstract]
ABSTRACT: To investigate the relationship between the formation of pseudoepitheliomatous hyperplasia (PEH) and the mechanism of loss of some components from the basement membrane in epithelial interstitial junction (EIJ) in the treatment of cutaneous wounds, when formation of PEH lesion was induced. Morphological change in epithelial tissue was observed with histopathologic method and electronic microscopy in 11 specimens of PEH lesions and 6 specimens of normal skin adjacent to PEH (PEH-N) from 11 patients with injured skin. The expression characteristics and distribution of pan-cytokeratin (p-CK), matrix metalloproteinase-2 (MMP-2), MMP-3, MMP-9, proliferating cell nuclear antigen (PCNA), epithelial cadherin(E-Cad) and beta-catenin(beta-Cat) in EMJ were detected with immunohistochemical methods. Epithelial cells expressing P-CK presented squamous epithelialization and extended into deep layer of mesenchyma. In epithelium-mesenchyma junction, where IV type collagen and laminin were weakly expressed, the protein contents of p-CK, E-Cad, MMP-2, MMP-3 MMP-9 were decreased, whilst the immunochemical staining of beta-Cat and PCNA was apparently increased. In the junction, epithelial basal cells were observed to migrate and to depart from basal membrane; epithelial islands and isolated epithelial cells expressing p-CK in mesenchyma could be observed. Ultrastructural observation revealed deformation of epithelial basal cells, increment of nucleus/cytoplasm ratio, loosened intercellular junctions, decrement of electronic density of BM and derangement of BM structure could be observed. Reduction in the capability of epithelial basal cells adhesion, differentiation and formation of basement membrane and cytokeratin in PEH associated with wound may be the crucial cause which controls epithelial cells migration into mesenchyma. That the contents of ColIV and LN were decreased may not be associated with MMPs, but with enhancement of the ratio of beta-Cat/E-Cad signal might be the important mechanism of dedifferentiation of epithelial basal cells and the loss of ability of structure formation and cellular migration.
Article: [Clinical significance of detection of serum hyaluronic acid concentration in severe burn patients].[Show abstract] [Hide abstract]
ABSTRACT: To study the relationship between the changes in serum hyaluronic acid (HA) concentrations and injury of hepatocytes in severe burn patients. Radioimmunoassay and enzyme-linked immunosorbent assay (ELISA) were used to detect HA and tumor necrosis factor-alpha(TNF-alpha) concentrations in serum, and biochemical indexes for hepatic function and renal function in burn patients that were divided into different groups: systemic inflammatory response syndrome(SIRS), multiple organ dysfunction syndrome(MODS). Multiple organ failure(MOF) and non-surviving patient groups. In two weeks after burns, the serum HA concentration attained a high level. With the increase of severity of disease, the values of the serum HA concentration were elevated progressively (P<0.001). At the onset of MOF till death, the serum HA content was rapidly decreased. Lineal correlation analysis indicated that the change in the serum HA concentration was closely correlated with SIRS, burn sepsis, MODS and death (P<0.01). It was positively correlated with TNF-alpha, aspartate aminotransferase (AST) and total bilirubin (P<0.05 or P<0.01), and negatively correlated with plasma albumin and albumin/globulin(both P<0.05). The increment in serum HA levels is relate with the impairment of the hepatic endothelial cells due to TNF-alpha etc. The HA content in serum can be used as a sensitive indicator for judging injury of liver, seriousness of the injury, and prognosis of the patient.
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Shandong UniversityChi-nan-shih, Shandong Sheng, China
307 Hospital of the Chinese People's Liberation ArmyPeping, Beijing, China


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Author Finds Migrating Animals Have 'No Way Home'
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Hey, I'm Kathryn!
Hi there! I'm an architect and artist living in beautiful Philadelphia. Since I love city life - being able to walk everywhere, having easy access to great restaurants and shops and friends right around the corner - I look for similar qualities in places I travel to.
I love visiting museums, making art and, well, shopping. My favorite thing to do when I travel, though, is stroll around the streets looking at buildings and popping into cafes. Being an architect, I'm really interested in observing the built environment wherever I go. When I first mover to Philly, I actually tripped frequently on the sidewalks because I was always looking up. I'll stop in a cafe several times throughout the day as well, both to compare coffee and pastries and take a rest after a long day of walking.
My favorite travel destinations include Japan, where I rung in the millenium, Rome, where I studied for a semester and London, a city I constantly return to. Everywhere I go I like to try different cuisines and have found that there is very little that I don't enjoy.
I look forward to meeting new people, whether at home or away, and have an easy time engaging with strangers in conversation. I've made some great, lasting friendships through engaging random people in the neighborhood, the cafe and even the gym.
I can't wait to travel to more far out destinations!


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Man Talk
This Sunday, Keith is keeping it extra real in an all-new episode of TD Jakes Presents: Mind, Body & Soul at 12P/11C! (Photo: Frazer Harrison/Getty Images)
Mind, Body & Soul Welcomes Marvin Sapp and Devon Franklin
© 2016 BET Interactive, LLC, a wholly owned subsidiary of Black Entertainment Television LLC. All rights reserved.


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Looking for boarding facility and good lesson program in Calgary AB
I will be moving to Calgary this summer and am looking for a good place to board my horse.
My gelding is just turning 4 and we are planning to do the jumpers and therefore would like a hunter/jumper oriented barn. A heated barn and indoor is a must as I don't deal well with the cold :)
We also love trails and therefore would like access to some trails as well.
Great horse care and friendly atmosphere is most important.
I would love to hear any recommendations on great barns.
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updated 04/21/2013 AT 10:00 AM ET
•originally published 04/22/2013 AT 6:00 AM ET
It was a day of pampering for Katie Holmes and daughter Suri Cruise on Saturday.
Just two days after turning 7, Suri indulged in an afternoon of manicures and pedicures at Tribeca's i-Plaza Nail & Spa in New York City.
Nestled in between Holmes and Holmes's mother, Kathleen, Suri played on her iPad as the trio got pedicures. Meanwhile, Holmes and her mother were texting and reading on their phones.
Getting a pedicure appeared to be nothing new for Tom Cruise's youngest child, who sat in the chair quietly as a nail technician worked on her feet.
Soon after, Suri got her fingernails done while mom and grandmother continued to de-stress at the pedicure station.
Once she finished, she showed Holmes her nails and said, "Look mommy!" to which Holmes responded, "It's so pretty."
Spot a celebrity? Tweet us your sighting
@peoplemag with #CITA and it could appear on PEOPLE.com!
— People magazine (@peoplemag) August 7, 2012


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Average Rating
User Reviews
3 out of 5 people found this review helpful:6 men, 1 girl, no romance?!Girl has power to save the world. Girl has four boys to protect her and some others that mill around. Girl tries to save world, doesn't always work.Read more
It's a reverse harem with no romance plot. Just a lot of "everyone mean so much to me" and "we have to protect our important people." Nice animation, pretty men-things to look at, but in general, not a lot going on between characters. The plot's ...
Has it's quirks, but overall very much enjoyed.The Thanatos could be scarier, or a little more realistic looking. The storyline is good, and though she's weak, the purpose of her having a bunch of handsome bodyguards is because she is weak! It's only the first season so it could easily pick up in the second one. The ending theme is from TegoMass, which is one of my favourites, and the intro theme is great as well. I started to watch it and ...Read more
The Start of Neo Angelique AbyssThis anime has been very good so far, though not outstanding.Read more
There are the "super powers" aka purifiers.
There is the female lead and her harlem of men all destined to protect her.
She has the strongest power, but can't defeat anything with out the help of her men.
She's way to gentle for me to believe I could be her, but it's easy to like her.
The guys all have different personalities and ...
6 out of 7 people found this review helpful:Romance and Heroes and MonstersThis has adventure and romance and a little humor in it as well. The setting is beautiful and the characters are all just as gorgeous in this anime. There's a little bit of history and myth in it besides fiction. I liked it because the imagination in creating this anime is great.Read more
Someone has a gift for story telling for sure.
This leaves you to dream of having just as many young gentlemen ...
2 out of 2 people found this review helpful:Watch it, it's good.At first I wasn't sure if I would enjoy this anime or not, because I couldn't find any info to tell me what it was about. So I decided to go ahead and watch it, I have ttto say I've greatly enjoyed this anime. The characters are good, the animation and character development is good too. The story line is intresting yet easy to follow and the music only adds to how good this anime is. I highly ...Read more


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HN-BFT037 Buffalo Tools
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Guess that's why the ground sip the wine
Lyric Meaning
A common rap theme is to "pour out a little liquor" for your fallen homies.
In the hood when one of the homies dies, wine is poured on the spot they died which represents them letting their dead homie take one last sip.
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From Wikipedia:
Charles Robert Darwin was born in Shrewsbury, Shropshire, England on 12 February 1809 at his family home, the Mount.[10] He was the fifth of six children of wealthy society doctor and financier Robert Darwin, and Susannah Darwin (née Wedgwood). He was the grandson of Erasmus Darwin on his father's side, and of Josiah Wedgwood on his mother's side. Both families were largely Unitarian, though the Wedgwoods were adopting Anglicanism. Robert Darwin, himself quietly a freethinker, had baby Charles baptised in the Anglican Church, but Charles and his siblings attended the Unitarian chapel with their mother. The eight year old Charles already had a taste for natural history and collecting when he joined the day school run by its preacher in 1817. That July, his mother died. From September 1818, he joined his older brother Erasmus attending the nearby Anglican Shrewsbury School as a boarder.[11]
Darwin spent the summer of 1825 as an apprentice doctor, helping his father treat the poor of Shropshire, before going with Erasmus to the University of Edinburgh. He found lectures dull and surgery distressing, so neglected his medical studies. He learned taxidermy from John Edmonstone, a freed black slave who had accompanied Charles Waterton in the South American rainforest, and often sat with this "very pleasant and intelligent man".[12]
In Darwin's second year he joined the Plinian Society, a student natural history group whose debates strayed into radical materialism. He assisted Robert Edmund Grant's investigations of the anatomy and life cycle of marine invertebrates in the Firth of Forth, and in March 1827 presented at the Plinian his own discovery that black spores found in oyster shells were the eggs of a skate leech. One day, Grant praised Lamarck's evolutionary ideas. Darwin was astonished, but had recently read the similar ideas of his grandfather Erasmus and remained indifferent.[13] Darwin was rather bored by Robert Jameson's natural history course which covered geology including the debate between Neptunism and Plutonism. He learnt classification of plants, and assisted with work on the collections of the University Museum, one of the largest museums in Europe at the time.[14]
This neglect of medical studies annoyed his father, who shrewdly sent him to Christ's College, Cambridge, for a Bachelor of Arts degree as the first step towards becoming an Anglican parson.[15] Darwin began there in January 1828, but preferred riding and shooting to studying. His cousin Fox introduced him to the popular craze for beetle collecting which he pursued zealously, getting some of his finds published in Stevens' Illustrations of British entomology. He became a close friend and follower of botany professor John Stevens Henslow and met other leading naturalists who saw scientific work as religious natural theology, becoming known to these dons as "the man who walks with Henslowâ€


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A spa day for two people at the Breadsall Priory Marriott Hotel & Country Club, including a massage or facial and a glass of bubbly each, is now £59 -- up to 55% less than the regular cost.
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Best Radio DJ (2001)
Cindy Scull, KEGL-FM 97.1 "The Eagle"
There's no science to this choice. This is as subjective as "Best of" gets. Here's the story: Many, many years ago, in a time known as "the '80s," there was an amazingly handsome young man who had a crush on the eighth-grade bad girl. She smoked, she had big, wild hair, she cussed a lot. And she liked to rock. She loved Kiss, Judas Priest, Ozzy, anything that qualified as metal-rock back in the day. She wore nothing but black concert T-shirts to school, and she always got backstage. She was also extremely smart, one of the top graduates at her high school who got a full scholarship to college. But she dropped out to become a DJ at the rock-and-roll radio station she grew up listening to. Years later, her secret crush, this handsome young man, would become a famously successful writer, so successful that he now writes "Best of" items for a weekly alternative newspaper. Is that bad little girl Cindy Scull, the whiskey-voiced DJ who spins hard rock from 3 to 7 p.m. every day and puts up shots of herself in bikinis on the Eagle's Web site? No. But she sounds just like her.


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Mayfair Co-Op (Drew & Cate's preschool) is hosting a Cash Raffle. Five cash prizes will be awarded on Tuesday, November 24: $200, $100, $100, $50, & $50. Since a very small number of $25 tickets have been sold, your chances to win are great! To enter the drawing, contact Emily Kamp by Sunday, November 22: 248-787-5200.
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5 cold and flu symptoms you should never ignore
We're entering that season when there will be plenty of coughing, headaches and muscle pain. It's likely a "cold" or "flu" but individuals should realize their symptoms could be an underlying and more dangerous problem
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You're the kind that soldiers through the pain, night sweats and all the tribulations of a flu or cold. You never miss a day of work and would never consider bothering a doctor or jamming a hospital emergency department.
Many admire your fortitude — but be careful. Microbiologist Dr. Allison McGeer of Mount Sinai Hospital says there are times when the "suspected symptoms" of the common cold are caused by something totally unrelated and perhaps even dangerous. Here are five signs it may be time to see your doctor:
Chest pain
While aches and pain often accompany days of wheezing and hacking, keep alert for constant or growing pain in the chest that will not subside. "It could be angina … it could be heart related," she said. "If you're in doubt, go to a hospital."
A fever 40C or over
It's normal for the flu to cause a fever — it helps your body fight infection. But McGeer says when your temperature hits 40C (104F), it's a sign of something could be amiss. And beware of a fever that spikes, sinks to normal, then roars up again. It could be a secondary infection somewhere else in your system.
Vomiting needs to be watched, because it can lead to dehydration, especially in children and the elderly. Headaches and dark urine are markers it may be time to see a doctor for intervention.
Shortness of breath
Coughing is fine — like a fever, it's one of the ways your body fights through an infection. But a persistent cough or shortness of breath could be a sign of pneumonia. And a cough that lasts more than three weeks or is accompanied by wheezing or shortness of breath might be bronchitis.
Painful swallowing
A sore throat is common with a cold, but McGeer says it may also be a sign of strep throat — especially common in children between ages 5 and 15.
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Educating consumers for more than 30 years
Back to Species Gallery
Species - Imported
Top portion is finished with water-base finish; bottom with oil-based finish
Color: Pale straw with occasional pinkish high-lights, tan colors, some medium gray/brown colors; over time overall color variation is muted with an ambering of the straw colors to darker tan.
Grain: All riftsawn.
Variations: Within Species And Grades: Even range of color shadings.
Sawing/Machining: Cuts easily; some splintering when routing.
Sanding: Sands satisfactorily if correct sanding sequence is followed.
Nailing: No known problems.
Finishing: No known finishing problems.
Comments Has an oily feel. Respiratory and dermatological allergic potential. Origin: Asia
Hardness/Janka: 1350 (5% harder than Northern red oak).
Dimensional Stability: Data not available.
Durability: Availability
Moderately available.
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Our Brother Alephs and Sister B'nai B'rith Girls,
As it is every year, BBG Founders' Day is April 22nd and AZA Founders' Day (effectively, BBYO's birthday) is May 3rd. Celebration will be exactly how Sam and Anita would have wanted it: simultaneous, worldwide, in the chapters and through whatever is best for each individual community. Our goal is to see every chapter mark Founders' Day in some way. To help this goal become a reality, we offer a list of program prompts that your chapter or community can utilize or incorporate into existing programs already on the calendar.
Additionally, consider Founders' Day as the culminating point of your chapters' Spring recruitment efforts! Between now and Founders' Day, make the extra push to recruit new members to your chapter and council/region. Imagine how proud Sam and Anita would be if we were to exceed our membership goals while celebrating Founders' Day! Need help or advice for member recruitment? If so, send us an email at firstname.lastname@example.com.
As you scroll down this page, you can download the AZA and BBG Founders' Day 2015 Resource Guide, learn about different movement moments associated with Founders' Day 2015 and follow Founders' Day on social media. This is a time for our Order to mobilize together to celebrate our history, our current successes and our future. If you would like additional consultation on programming, reach out to a member of the International Board or e-mail email@example.com. We wish you a joyous Founders' Day 2015!
Fraternally and respectfully submitted, we remain,
The 90th Grand Board of the Aleph Zadik Aleph and 70th International Board of the B'nai B'rith Girls
Show Our Pride Worldwide: AZA and BBG Letters Days - April 29
Show your AZA and BBG Spirit on Wednesday, April 29 by wearing your favorite AZA or BBG shirt as part of the first-ever AZA and BBG International Letters Day!
Be sure to tag #BBYOFoundersDay in all of your pictures of you and your friends in your BBYO swag! This is a great opportunity to engage peers that might not know much about AZA and BBG while displaying your Order pride across the community. #OnWednesdayWeWearLetters
Your Calendar!
How is your chapter celebrating Founders' Day?
What is your chapter doing to celebrate AZA and BBG Founders' Day 2015? Our goal is for every chapter across the Order to commemorate this historic moment for AZA and BBG by having a program either on AZA or BBG Founders' Day or some time in between the two dates.
Not sure what to do during Founders' Day 2015? If so, check out the AZA BBG Founders' Day 2015 Resource Guide for helpful programming ideas. If you need any further assistance, please email email@example.com. Once your chapter has planned its program for Founders' Day, use the form on the right to submit your chapter's program information. Throughout the entire year-long celebration of BBYO's 90th Anniversary we will be featuring all chapters who held programming during AZA and BBG Founders' Day 2015.
If your chapter is planning on holding AIT/MIT inductions, below are links to the official AZA 90th Anniversary and BBG 70th Anniversary Induction Scripts.
Celebrate Founders' Day 2015 on Social Media


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Renamon diamond storm by Aurelio-hl2Watch
©2012-2016 Aurelio-hl2
yes muajajajaja..
yes muajajajaja..
She's really something there.
Cool! Y nunca mejor dicho XD
She looks great! Everything's so smooth ^^
1 of her best moves ever! ! !
<3ed her digiyvolution
<3ed her digiyvolution
yea XD
Looks outstanding. One little problem though; you forgot the purple marking on her leg. Other than that, great pic!
Renamon does not have human breasts... She does have a form that does.
yes jeje, is my vercion..
the name is "Renamon Zero"
Zero means that out of the ordinary, something extraordinary...
the name is "Renamon Zero"
Zero means that out of the ordinary, something extraordinary...
How is that extraordinary? Of Renamon mods that is the most used and most pathetic one giving her a rack. So not original at all. If you had a normal renamon model not a pervmon one I would of faved it.
is not perversion, women's art..
Well you going to make an counter point or not you seemed like you tried but I see no counter point to what you said. are you saying a woman made the model I met plenty of perverted women.
I made the model, but the art is in the feminine figure...
Maybe but does not mean its artful. its confusing the real; iamge of renamon. Its been done to much and its just now a pain and rubbing a sore nerve. I mean Now people think renamon is a furry fantasy not an awesome fox digimon of butt kicking. and your adding to that.
this model does not show love, express hatred ..
see my 2 pictures of Renamon, note that no express love...
expresses action, hate and attack ^_^
see my 2 pictures of Renamon, note that no express love...
expresses action, hate and attack ^_^
excelente arte con el 3d. aurelio
love Renamon <3
I also...
que hermosa se ve renamon *¬*
Simplemente preciosa! El mejor modelo de Renamon, y no soy barbero.
y cada vez esta siendo mejorada... como le estoy dando seguimiento continuo asta terminarlos, se evaluan a un precio muy costoso!!!... pero yo soy carero y los ago gratis para ustedes, pero, deveran quedar finalizados para postear...


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Tuesday, September 3, 2013Wisconsin
It was a nice day, so we drove up to check on our caches along the old railroad bed. We wanted to see what it looked like near this one, as someone has removed the dam since we placed it just a little while ago! Wow! Did the water level ever recede! Poor beaver!!! We posted a couple new pics on the description to show the difference.
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Nice frindly hotel just 2 mins from the beach. Just a bit difficult to get to by public transport, had to use taxi which tend to be a bit pricey. Best bit ----- icecream in the shop across the road. wow!
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TripAdvisor awards a Certificate of Excellence to accommodations, attractions and restaurants that consistently earn great reviews from travelers.


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Top Definition
Denim jacket and jeans
Nice canadian tuxedo denim dan
von NinneR 7. Juli 2003
Made popular by the movie Super Troopers when the Sargeant appears wearing a denim jacket with a pair of jeans (could be matching or not)
You see someone wearing jeans and a jean jacket..."Hey Denim DAN, nice Canadian Tuxedo"
von Pat Craddock 10. August 2005
An outfit consisting of a denim jacket and demin jeans. To spice up the outfit a button down demin shirt may be worn.
Look at that goofy canuck in his canadian tuxedo.
von hajimera yarulsevski 8. Mai 2006
When a person wears a denim jacket with jeans. Usually accentuated by a lame T-shirt.
Billy Jack was a big fan of Canadian tuxedoes.
von The_Reverend 21. August 2006
Wearing denim on demin, bitches.
Yeah, s'called a Canadian Tuxedo.
von Broomfield 6. April 2011
Today it refers to any outfit consisting of a denim jacket, with denim jeans. Originating in the 1950s, crooner Bing Crosby was nearly rejected from an upscale hotel in Vancouver, BC (Canada) because he had been wearing an all-denim outfit. Levis heard of this and sent him a special-made all denim tuxedo.
Justin looked completely ridiculous wearing his Canadian tuxedo.
von Demacsspider 3. April 2015
When you pour a bottle of maple syrup over your lady when having sex in a Tim Hortons Bathroom.
"Hey Sarah, why are you so sticky?"
"Oh Jim decided to give me a Canadian Tuxedo yesterday."
"Oh Jim decided to give me a Canadian Tuxedo yesterday."
von MrDingDing 23. Dezember 2015


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The Sydney Morning Herald (NSW : 1842 - 1954)(about)
Previous issue Saturday 3 April 1897 Next issue
Previous page of 16 Next page
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1 correction by HJOHFF - Show corrections
The funeral of the late Herr Carl Ludwig Sahl, German Consul, took place at the Waverley Cemetery yesterday afternoon. The procession left the deceased's late residence, Longwood, shortly after 3 p.m. On the coffin were placed the late Consul's sword, official hat and the decorations bestowed upon him by the German Emperor. The plate on the coffin was inscribed as fol- lows -'"Carl Ludwig Sahl, Imperial German Consul. Born January 8, 1840; died April 1, 1897" A very long trin of carriages, testifying to the esteem in which the deceased was held by all classes of the community, followed the remains to the cemetery. Both the Gorman warships, Falke and Bussard, and theAustrian warship Albatross sent detachment. The combined bands of tho Falke and Bussard were present and playcd a Lutheran hymn as the coffin was being carried into tho hearse. Among those who followed were-Herr Peldram (Con- sul-General for Germain), Colonel Bell (United States Consul), M Baird d' Aunet (French Consul-General), Herr Paul Russian Consul), M Maniachi (Greek Consul) Mr Macgregoro (Consul for Peru), Mr F B Free- hill (Consul for Spain) Mr Boesen (Consul for Denmark), Captain J. Mergell (AuátriunConsul) Mr J T Tillock (Argentine Consul) the commanders» of the foreign warship*) Captain Krieg, Winkler, and von Mauler; Drs Helms, Eichler and Lillie
Mr Jessep, M.L.A.; Messrs C.B. Fairfax, Joseph, H Mort, L Mort, Giles Jackson, and re- representatives from the German societies and most of the shipping firms in Sydney. The chief mourners were Mrs Sahl who was accompanied by Miss Binnie and Herr Otto Bauer (cousin of the de- cease.) The service at the grave was con- ducted in the German language by Pastor Schenck, Lutheran Minister. A number of beautiful wreath« were sent by the following - Mr ant Mrs Otto Bauer, Herr Peldram the com- manders md officers of the IMS Bussard and Falko Dr Lillie, the office staff of Messrs Rabone, Feez, and Co., Mr J. Mergell, the staff of the Ger- man-Austrian s s Company, Lieutenant Colonel Walker, Mrs and Miss Mitchell, Mrs A G Milson, Mr and Mrs Reuz, Mrs don der Heyde, Mr and Mrs W.H. Henderson, Pastor and Mrs Schenck, Messrs Potts and Paull, Mr and Mrs Lohmann, Mr and Mrs Roth, Mr and Mrs Boesen, Mi C Winnecke, Mr and Mrs A Loughnan Mr and Mrs J.C. Ellis, the Misses Fost and others, the German Club, Mr M Rutlv, the German Con- cordia Club, Mr Meciszewaki, Mrs and Miss Binnie Mr and Mrs Machen, Mr Killani, the German Glee Club, The women's committee of the German Church, Captain Staben, (German barque Ocean), Ciptain Muller (German ship Lika), and the servants at Longwood
The majority of the wreaths were provided by Messrs. Searl and Sons and Miss Goodenough. The funeral arrangements were carried out by Mrs. P. Kirby and Sons.
In consequence of the death of the German Consul, Herr Sahl, not only the German officers and many of the ships, but also the foreign consulates in Sydney had their flags at half must yesterday


text: Bussana Vecchia is the artist's small town which was ruined during an hearthquake, so don't expect luxury restaurants. La Casaccia restaurant is located at the end of the streets which can be driven. Then you have to park and walk 200mt to the restaurant. Terrace wooden tables and long seats... read more


text: Support 88Nine And This Artist: Buy On Amazon Buy On iTunes Africando is a musical project formed in 1990 to unite New York-based salsa musicians with Senegalese vocalists. Subsequently, under the name Africando All Stars, musicians from other African countries were included. Salsa has been a hugely popular style in Central and West Africa since the 1940s-1950s, and the goal of Africando was to merge salsa rhythms from both sides of the Atlantic, mainly based on the African salsa tradition. Read more about Africando on Last.fm. User-contributed text is available under the Creative Commons By-SA License and may also be available under the GNU FDL. Tracks We Played Yay Boy iTunes Yay Boy Tierra Tradicional vol. 2 Last Played on March 11, 2014 2:52am Doundari iTunes Doundari Viva Africando Last Played on January 15, 2014 12:12pm View the discussion thread.


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London 2012 design icons – the Olympic torch
The Olympic Torch has been the most visible of the London 2012 Olympic design icons in the run-up to the Games.
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Dresden 4 Seasons Angels
- Sold for: Start Free Trial or Sign In to see what it's worth.
- Item Category: Ceramics
- Source: eBay
- Sold Date: Mar 09,2007
- Channel: Online Auction
Hard to find are the beautiful Dresden 4 Seasons Angels. Three are in mint condition with the fourth angel(spring) has had its wing repaired.On the bottom is D, original Germany in blue. They run between 5 1/2 -6 inches tall. Will ship anyw


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1 Kings 21:27New King James Version (NKJV)
27 So it was, when Ahab heard those words, that he tore his clothes and put sackcloth on his body, and fasted and lay in sackcloth, and went about mourning.
New King James Version (NKJV)
Scripture taken from the New King James Version®. Copyright © 1982 by Thomas Nelson. Used by permission. All rights reserved.
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Notes on the Evolution of Decorated and Large Types by Rob Roy Kelly
The first and most authoritative history of wood type in the United States has been reissued in paperback. Long out of print, the book is still regarded by scholars and designers as an invaluable resource for a rich legacy of typographic art. The book features a new foreword exploring the renewal of interest in the subject among designers, graphic artists, letterpress printers, and typographers.
See the listings on the Composing Room page for the appropriate Sterling Toggle Hooks and key that are required to use these bases. When plates are ordered (quarter inch thick, or .250")for use on these bases, advise your photoengraver that the plate will be used on a Sterling Honeycomb base and they will saw the appropriate bevel on each side of the plate. Magnesium or copper plates may be used that will provide the best base and sharpest image for letterpress.
AlignMate is used to check for straightness of text and graphics on paper sizes up to 11x14". It has scales in both picas and inches, a clear plastic overlay sheet with a grid pattern marked in 1/16ths of an inch that the printed sheet is slipped in under to check for alignment.
NA Graphics, P.O. Box 467, 4 Mears Avenue, Silverton, Colorado 81433
Phone: (970) 387-0212 - Fax: (970) 387-0127


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You are hereHome ›
This is an activity about the electromagnetic spectrum and how the different wavelengths of light are used to capture the most complete picture of objects in space. Learners will view images of our galaxy in multiple wavelengths to compare and analyze what is seen. This activity requires a computer with Internet access, and is Astronomy Activity 3 in a larger resource entitled Space Update.
Rice Space InstituteLast modified 2006
Education Level: Elementary school:Upper elementary:Grade 5, Middle school, High school
Audience Refinement: Educator
Resource Type
Learning Time
Materials Cost
Instructional Strategies
Educational Standards
Access Restrictions: Limited free access


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Web Content, Digital Assets, Form Builder, SEO Tools
Multisite Management, Multilingual Support, Site Synchronization, Deployment Options, Security, Scalability
Personalization, Email Marketing, Mobile, Social Media, Analytics
Integration Platform, Connector for Salesforce, Connector for Microsoft Dynamics CRM, Connector for Marketo, Connector for SharePoint
Product Catalogs, Multiple Storefronts, Targeted Offers, Payment Processing, Order Management
Custom Content Types, UI Framework, ASP.NET MVC Support, Visual Studio Support, Comprehensive API
Behaviour Tracking, Data Integration, Persona Profiling, Lead Scoring
Audience Segmentation, Predictive Analytics, Campaign Recommendations, Campaign Tracking
Marketing Attribution, Conversion Tracking
Predictive Personalization, Persona-Based Targeting
SUMO is a digital agency formed in Perth in 2000. Since the beginning they have been working with anything that can be displayed on a screen.
They have focused themselves to be the digital specialists they are today. SUMO is not just a web designer or a web developer. They are a complete digital agency, offering services that span high level strategic planning, search marketing, mobile (including the iPhone) development and Bluetooth development, as well as what you'd expect– beautiful functional web design and advanced web application development.
Need help finding a partner?
Let us help you find a Sitefinity Solution Partner
Copyright © 2002-2015 Telerik. All rights reserved.Sitefinity ASP.NET CMS is a product of


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Here's why your faith is not only a privilege; it's also a responsibility. read more
Charisma Magazine
Page 25 of 111
Why You Should Make Out With Your Spouse
If you're not normally given to public displays of affection—or to very little physical affection at all—here are some strong benefits simple kisses can bring. read more
Against the Odds, This Incredible Love Story Has Persevered For 75 Years
On the eve of Valentine's Day, Pastor Mark Rutland pays a heartfelt tribute to his parents, who recently celebrated their 75th wedding anniversary. read more
6 Ways to Blow a Special Day
With Valentine's Day upon us, how can you avoid these mistakes when it comes to your spouse? read more
5 Creative and Unique Types of Valentine's Gifts
It's an old saying, but it still holds true. It's not what you give, but what matters more is how much thought and care you put into a Valentine's Day gift. read more
Dad, Here Are Your Lines
If you're ready to kick it up a notch and daily invest in the heart space of your daughter, here is a decoder version of how girls understand and translate your responses to them. read more
How to Approach Issues That Divide People
What do you think it takes to have a constructive conversation with someone you disagree with strongly? read more
5 Things You Think Say 'I Love You,' but Don't
What are some gifts you've given to your spouse or things you've said or done that you thought would please them but turned out to be a disaster? read more
5 Ways to Win Battles as an Overwhelming Underdog
The odds were against David, but he slew Goliath. Here's how to overcome the odds against you. read more
Are We Sinning at Times, or Perhaps Simply Foolish?
It's worth distinguishing between an error in judgment and an integrity problem. Can you discern which is which? read more
10 Rules of Christian Dating
And here's why that person isn't "the one."
Faith Comes by Hearing What Is Told
Get quality Christian content in a variety of programs including news, leadership, inspiring stories, women's topics, sports, and even more.
WATCH: The 1 Thing the Devil Doesn't Want to Hear You Say
Kyle Winkler reveals the one powerful declaration that makes the devil shrivel in ...
God Is Pouring Out Prophetic Visions in This Season
God is looking for those with a Habakkuk spirit who will not only see and hear, but record and ...
How To Get Your Message Beyond Your Four Walls
From blogging and social media to podcasting and book publishing, learn how these platforms can be used to reach a new audience.
2016: The Year of the Rising Remnant
During this next seven-year season, the Lord is bringing forth His rising remnant as the Joshua ...
How God Speaks While You're Sleeping
Here's how your inactive state can be spiritually active.
4 Things the Enemy Wants From You
If you love God, you're a target and you need to be wise to the devil's devices.
Could Thought Curses Be Oppressing Your Mind?
If you're a charismatic believer, you've probably heard of word curses. Now let's ...
When a 'Radical' Muslim Finds Jesus
"I had never felt love before."
Prophetic Word: God Is Raising Your Profile in 2016
This prophetic word is important for us all to hear and pray over.
Faith Comes by Hearing What Is Told
Get quality Christian content in a variety of programs including news, leadership, inspiring stories, women's topics, sports, and even more.
When a Smile Is Supernatural
Would you be smiling if you were in my friend Nelson Barigye's situation?
Spirit of Grief Rises to Take the Fight Out of God's People
If this is you, get alone with God today and do these three things.
How To Get Your Message Beyond Your Four Walls
From blogging and social media to podcasting and book publishing, learn how these platforms can be used to reach a new audience.
When God Tells You to Do Something That Scares You
Early on in my ministry, a woman came to our church seeking deliverance from evil spirits that were ...
How Would You Know if You Had a Religious Spirit?
The question is significant.
An Open Letter to Cam Newton
Cam Newton, you may not care about your behavior after the Super Bowl right now, but remember this: ...
Why Women Should Embrace the 'Uncertainty' of Singleness
Mandy Hale, 36, says she is determined to live her best life now, even without the man many in the ...
5 Cost-Effective Ways to Take Better Care of Yourself
No diets, no exercise regimen. Just do these things and your health will improve, guaranteed.
Spirit-Filled Believers, Help Ted Cruz Gain Momentum
While it takes more than winning in New Hampshire to gain the nomination and presidency, these ...
God's Power at Work in the Church Today
Charisma's founder, Steve Strang writes about today's hottest topics affecting the Christian faith.
Why Is a Large Segment of the Church Powerless?
God will simply not anoint these things.
When You Can't Pray Anymore
Before you give up thinking that this is not God's will, read this.


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Front Page
In Brief
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Print Text Of This Issue
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About Monitor
The University is beginning a major road construction project that will impact about 75 percent of campus this summer. Parking, deliveries and pedestrian routes will all be affected for a short but intense time, said Project Architect Marc Brunner, design and construction. Plans must be adapted for summer graduation, conference programs and camps.The main thrust of the project is to widen Ridge and Willard streets and make them safer for both cars and pedestrians. Willard Street, which currently runs only between Ridge and East Merry Avenue, will eventually be extended north to Poe Road. A new parking lot will be added across Poe on part of the airport's vacant land. The new lot will help compensate for the parking that will be lost to the construction of the Northwest Residence hall.The goal is to have Ridge widened and parking lots reopened by the time school begins in mid-August, Brunner said.Work on the Ridge Street project is slated to begin today (June 7), weather permitting. Most disruptive will be the necessary closings of Lots N and 14, which provide much of the parking space in the middle of campus. The closure of Willard will also pose access challenges for the Student Health Center and Moore Musical Arts Center, said Brunner, but emergency vehicles will always be able to get through. Pedestrian access to the health center will also be maintained. Departments should work with their suppliers to determine the best access to their buildings.While lots N and 14 are closed, the lane between the Fine Arts Center and the Jerome Library will also be closed to through traffic for installation of a water line. Delivery vehicles will be able to pull in and out but not drive through to Ridge Street.Intermittent closures of Lot 5, on Merry west of Willard, will also occur through about Aug. 13, Brunner said.BGSU will see the greatest amount of construction going on at once in its history. Combined with the ongoing projects to improve the South Tunnel, build the Stroh and Wolfe centers, demolish part of McDonald West to add a new dining facility, and build two residence halls, "the campus will change this summer more than it has in the past 25 years," said University Architect Jim McArthur, Office of Design and Construction.For a map with dates of all campus construction projects, visitwww.bgsu.edu/downloads/finance/file65484.pdf


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E-Cat Home Device – Bullet Trains Of The Future?
We have been told by Rossi that E-Cat home is in the works and the manufacturing would soon commence (preliminary in autumn), and after that it's time for the sales to begin (preliminary winter). But no specifics have been offered yet, although the inventor did promise that within several weeks this issue would be clarified and "precise schedule" would be shared with the general public, hence setting the stage for what's to come.
Speaking of what's to come, there have been quite a few predictions as to how LENR technology can be utilized and specifically, what the humanity could make of the ECat. It is clear that for now the Italian engineer responsible for the invention is working hard on his E-Cat home modules, and is busy with the developments in this field, as he is planning to unveil one million pieces by the end of this year (or in the vicinity). But once the E-Cat home hits the market, obviously Rossi will have more time for other undertakings for his Energy Catalyzer to tame.
Of course, as Rossi and his specialists and his customer(s) and his partners (for instance National Instruments that provide his modules with electronics and software support) stumble upon some discoveries, it should be expected that it would be either implemented or placed on hold until an opportune time arrives.
One of the ideas that surfaced concerns the utilization of Energy Catalyzer as the engine that would generate high speed trains. Now these speedy machines are driven by electricity. Even at the low voltage that it does take, it still does use quite some. Consider the steam generated by E-Cats as the fuel for the bullet trains of this kind. Steam-powered engines are not a novelty, and as such perhaps bullet trains may incorporate Rossi's technology for their efficiency and lowering of their costs.
What do you think?
Category: E-Cat, E-cat Home
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See definition in Oxford Advanced Learner's Dictionary
Definition of drag up in English:
informal Dress up in clothes more conventionally worn by the opposite sex: he drags up to play a high-heeled bordello inmate
More example sentences
- Dave drags up to become his own female backing group - all three of them!
- The torrential confession of Detective-Sergeant Bruce Robertson, a cocaine-addicted, eczema - ridden, worm-eaten Edinburgh copper, entailed the shaven-headed Burn dragging up.
- I dreamed I had been dragging up for work since I started, and they were all convinced I was a girl.
What do you find interesting about this word or phrase?
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Favre to let Vikes know by July 30
Updated: July 16, 2009, 12:58 AM ETAssociated Press
HATTIESBURG, Miss. -- Brett Favre acknowledged he's "running out of time" to decide whether he'll play for the Minnesota Vikings this season.
The quarterback told The Associated Press that he'll give the Vikings an answer on whether he'll play by the July 30 start of training camp. Favre has been working out with the Oak Grove High School football team three days a week all summer, but added a Sunday workout this week.
"There's two weeks left and I'm doing everything I can," ...
Read full story
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Company Overview of Tsinghua University
BOARD MEMBERS AFFILIATED WITH Gu Binglin *
President and Member of Advisory Board
MOST CONNECTED PEOPLE TO Gu Binglin
|Alberto Ibargüen
|140 Relationships
|Niall FitzGerald
|81 Relationships
|Khoon Ean Kuok
|70 Relationships
|P. Miles Young
|67 Relationships
|Raymundo A. Yu
|28 Relationships
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To contact Tsinghua University, please visit . Company data is provided by Capital IQ. Please use this form to report any data issues.
Our data partners will research the update request and update the information on this page if necessary. Research and follow-up could take several weeks. If you have questions, you can contact them at firstname.lastname@example.com.


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The Bible Belt is the Porn Belt. According to a new study, the more you say you literally believe in the Bible, the more you watch porn. At least that's the inevitable fact-based conclusion drawn from the biggest study of internet Google porn searches by region. Here's some excerpts from a brilliant article by Valerie Tarico first published in Alternet that proves the point. (Reprinted by permission.)Smut in Jesusland: "The honest truth is that we all have our failings, Christian or not, li … [Read more...]
I haven't the foggiest idea what prayer does– I do know that I can't get through my day without praying…
Why does prayer feel both right and normal to me and crazy, too? The best I can do is offer this analogy. In the movie Close Encounters of the Third Kind, people receive a vision of a mountain to which they're being called. They don't know what they're seeing, let alone why. They don't believe in callings per se. They just have to go there. In the same way, I just have to pray. And while I know that soon my grandchildren will be asking me tough questions about whether any of this spiritual mumbo- … [Read more...]
Here's a clip from my interview in "Jesus, Don't Let Me Die Before I've Had Sex." Matt Barber - the director of Jesus, Don't Let Me Die Before I've Had Sex - a documentary - is posting clips from the project on YouTube. Here's mine.Click HERE for more clips from the movie and watch! … [Read more...]


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Perusing recently released privacy publications
European Data Protection Law: Corporate Regulation and Compliance
By Christopher Kuner
Oxford University Press
Early in his career, Christopher Kuner cut his teeth on European data protection law while working at a large German firm. He worked in corporate law, but kept seeing data protection questions pop up as companies merged and pooled databases. "Gradually,"he says, "the data protection issues began eating up all my time."
Some years have passed, privacy has entered the mainstream, and the same issues continue to eat Kuner's time. It's his full-standing specialty at Hunton & Williams, where he heads the International Privacy and Information Management Practice from his office in Brussels
Recently Kuner released the second edition of his book European Data Protection Law: Corporate Regulation and Compliance. The 550-page tome covers European data protection law with a focus on areas of interest to companies.
Since the first edition in 2002, "privacy has obviously exploded," says Kuner. Because of that, the new edition is double the size with a greatly expanded scope. European data protection supervisor Peter Hustinx wrote the foreword. Recently, the book became the first in-depth treatise on European data protection law to be published in Chinese.
For more information: www.oup.com/uk/ catalogue/?ci=9780199283859
"Kuner's diligence is evident in his research, his skill demonstrated by the book's accessible prose, and his practitioner's sensibilities shown by his practical explanations and reference to the underlying texts. This book is a must for any serious privacy practitioner's library."
—D. Reed Freeman, Partner, Kelley, Drye & Warren LLP
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Gallery | Uncovered streetcar rails to be removed in New Albany
Old trolley track can be seen as Eli Meredith uses a concrete cutter to prepare a curb installation for a median on Main Street in New Albany as part of a downtown improvement project. Medians will be installed to slow traffic as well as house plants and trees that will beautify the area once completed. Aug. 12, 2014 By Matt Stone/The C-J
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[headline]Twitter Stats
@headline - Tracking since September 26, 2008
2ch のヘッドラインニュースを適当に拾ってポストしています。ニュースジャンキーなあなたへ。by @ryochin
[headline] Tweets
@headline has posted 6,204 tweets in the last 30 days, which translates to an average of 206.8 tweets per day.
[headline] Followers
@headline has 7,015 followers.
This account is #881,539 in the worldwide rank of the most popular Twitter users.
[headline] Following
@headline is following 2 Twitter accounts.
Last month this account followed no users.
[headline] Predictions & Milestones
@headline will hit 6,964 followers in the next 3 months, and 6,810 in one year.
You are on [headline]'s Twitter stats page
We track these Twitter stats since September 26, 2008 . You can see how many followers [headline] lost or gained and what the prediction is for tomorrow or the next 15 days, together with all kinds of other stats like rank compared to all Twitter users, tweets etc.
Why don't you give it a try and compare [headline] to yourself ? Or if you are [headline] get even more feature rich & up-to-date stats with Premium & Pro Twitter Stats.
Twitter Counter is the #1 Twitter stats site powered by Twitter. It all started in June 12, 2008 and we grew rather rapidly because of our Twitter Counter badge. The button is a nice small image that shows your visitors how many followers you have on Twitter. Within a year the button was on many many blogs around the world and we displayed more than 100 million buttons in one month. We track follower stats for over 180 million users now.


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Ancient DNA in the genomes of modern humans influences a range of physiological traits.
Joeanna Arthur: Charting a Path
October 1, 2014|
Project Scientist, National Geospatial-Intelligence Agency. Age: 32
October 1, 2014|
Project Scientist, National Geospatial-Intelligence Agency. Age: 32
October 1, 2014|
Despite a lack of vision, a blind cavefish can count. Sort of.
October 1, 2014|
Sounds trigger a response in the visual cortex that predicts how accurately a person can identify a visual target.
September 30, 2014|
Mix of public, private, philanthropic, and academic investments will fund additional BRAIN Initiative-related projects.
September 25, 2014|
Using citation statistics, the firm forecasts which researchers are likely to take home science's top honors this year.
September 22, 2014|
The United Nations Security Council declares the situation in West Africa a "threat to international peace and security" and calls for even more resources to fight the spread of the Ebola virus.
September 16, 2014|
People can categorize words while asleep, a study shows.
September 4, 2014|
A study that identified genes linked to communication between different areas of the brain has been retracted by its authors because of statistical flaws.
September 1, 2014|
Why the brain produces musical hallucinations
September 1, 2014|
Studying handedness in chimps may shed light on the mysterious trait in humans.


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NASHVILLE, Tenn. (AP) -- Republican Gov. Bill Haslam has signed an executive order that eliminates a requirement for the governor and top aides to disclose how much they earn.
Under the order signed after Haslam took office on Saturday, the disclosure rules applying to himself and senior administration officials will be the same as those for members of the General Assembly. Those only requires them to list sources of income, but not how much they make.
The move wipes off the books former Democratic Gov. Phil Bredesen's first executive order of 2003, which required the top executive branch officials to make annual reports about their total earnings.
Haslam was heavily criticized during the campaign for refusing to say how much he earned from family owned Pilot, a national truck stop chain with annual revenues of about $20 billion.
(Copyright 2011 by The Associated Press. All Rights Reserved.)


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DIY Advent Calendar by PetitPlatWatch
©2012-2016 PetitPlat
this is beautiful~
What a cool idea!!! Do you mind if I use it?
A very nice song. Very inspiring. And a very strong message.
Thank you for your respect and I understand
Everyone a disservice to me because I am a Muslim I do not understand why
Everyone a disservice to me because I am a Muslim I do not understand why
Yeah. It's because some people think that Muslims are terrorists and stuff. But I don't care what they think because I am proud to be a Muslim, and you should too! Don't care what others think and just be proud of who you are. And always remember that there are a lot of people around the world who respect other religions and cultures. So don't worry!
That is too cute! What a great idea!!!
OMG....GREAT idea!
That is brilliant!


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https://www.owasp.org/index.php?title=J2EE_third_party_libraries_insecurity&feed=atom&action=history J2EE third party libraries insecurity - Revision history 2016-02-11T18:24:55Z Revision history for this page on the wiki MediaWiki 1.23.13 https://www.owasp.org/index.php?title=J2EE_third_party_libraries_insecurity&diff=120902&oldid=prev Damian Kolasa: Potential insecurities from using third party libraries in J2EE project 2011-11-30T09:34:34Z
Potential insecurities from using third party libraries in J2EE project

New page

'''Introduction'''

 It might be obvious but I believe that from time to time everybody needs to get their memory refreshed. In these days software developers relay on third party libraries, to help them do their work faster. This is a potential way for a malicious code to sneak in to our most secure application. Imagine a library that parses JSON/CSV/XML, or does some other useful things for our app. This library is fairly simple, but contains a piece of code that will find all context variables that will contain URLs and passwords for other systems, or it can silently connect to our DB and start downloading our data. There is always issue of how will attacker export gathered informations but there is HTTP/MAIL/DNS/ICMP/file. Given how many open source projects are out there, and how much of them are in use, it is a big field to mess with.

 '''Why should it concern me ?'''

 Because nobody (or almost nobody) ever views the sources for library that's being used. Why ? - Time. Nobody has enough time to properly finish their project, not even thinking about viewing sources of libraries we use on daily basis. None sane manager will allow his developers to spend their time on analyzing thousands of lines of code. That is why this all could slip unnoticed.

 '''What can we do?'''

 As you probably already know there is not much that we can do about it, and we wont eliminate every threat. But what we can do:

 1. We can sign jars - but it doesn't do us any good because we already trust our source.
 2. We can review source code - but it is extremely time consuming, and sources doesn't have to match compiled classes so we should build jar ourselves.
 3. We can attach a security manager policy file to libraries - and I think this is a most cost effective countermeasure we can do.

 '''The policy file'''

 This file should be provided by library developer and contain informations on what this lib should have access to, i.e. file or net. It should be obvious that library that parses JSON should not access network or HDD. If we have such file attached to library we can analyze it in much shorter time and be able to tell, if this lib is safe. Of course if we won't use Security Manager or our brain or view security policy file there is nothing that would help.

 --[[User:Damian Kolasa|Damian Kolasa]] 04:34, 30 November 2011 (EST)

 {{Stub}}

 [[Category:OWASP Java Project]]
 Damian Kolasa


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Alice by SleetwealthWatch
©2011-2016 Sleetwealth
5" bust. She is NOT from Wonderland. will update with better pics later
This is amazing! Her eyebrows, are they painted on or are they actually there?
Love her! <3
This is amazing! Her eyes are so intense and her lips are fantastic.
I love those eyes...
looks like you've been busy, great work, like the varying faces
actually I took about a 2 month break other than that Im always making something.
Thanks I try to make them each different
Thanks I try to make them each different
oh it looks like "neobaroque"
I love her! How long have you been practicing sculpture for? How long did she take you?? xx
Genius !!
Fantastic work!
Spectacular, such an arresting piece
LOVELY, as always.
big fan of your work, you make me want to do stuff like that! great expression as always, she feels alive.
I really like the vibrant colors on this piece. VERY NICE work!
Peace Always,
the DragonLady
Peace Always,
the DragonLady
I just love your creations so much!
Woah, I am amazed.
And so a secret kiss
Brings madness with the bliss...
Brings madness with the bliss...
She came out great
What can i say?! There are no words for her...she's amazing!!! Better pics? The lightning in this pic is very good Nita!
I like the stitched leaves,they almost remind me of butterfly wings.Like Monarchs and Morphos or something.
Oh wow! She's just stunning! My favorite of yours so far. ^-^
Absolutely superb!
Gorgeous, I thought the head dress was butterflies at first haha.
Such a pretty face ♥
Such a pretty face ♥
Ohrur, Nita, she's now a manically depressed hay stacker with her pearubow, cheval'air, mummyanked frayarn and the treetopped Autumurmurderedibonneigh crepitates her voisentient...
Amazing work!
i can't say a thing this time,
it looks so adorable real that it is scary that it is a buste only,
love it really
it looks so adorable real that it is scary that it is a buste only,
love it really
I just LOVE her lips and the look in her eyes. Beautiful fabrics and hair as well.
Eerily beautiful ...I still can't get over how you manage to make these pieces look so lifelike when
they are so small. Excellent.
they are so small. Excellent.
This is how I envisioned Claudia from Anne Rice's "The Vampire Lestat"! Absolutely gorgeous, and compelling piece. The eyes are wonderful.
I love the plumped lips & scarlet-rimmed eyes......deliciously sinister,while still appearing lost & sweet!?


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In addition to credit cards,
we also accept Paypal & Google Wallet.
Start your own fashion sensation at the pool or aerobics class in this revolutionary chlorine-proof Krinkle® Suit from Penbrooke. Its great larger bust fit will keep you loyal and the longevity of its fabric will make believers out of any skeptics.
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• Scoop neckline
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- May be cut out and worn without lining
• Hand rinse in cold water after each ues
• 100% Endurotex Polyester
- Krinkle® chlorine proof
• Imported


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Welcome to our Website
Welcome to the Wiltshire County Netball Association Website
The county has a busy twitter account which will be used for news articles and articles.
Click Here to follow the county.
Feel free to take a look around, soon we will be adding a review page where you can add feedback and suggestions for the website.