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Publications (74)266.07 Total impact
Article: Polyphenols from green tea prevent antineuritogenic action of Nogo-A via 67-kDa laminin receptor and hydrogen peroxide[Show abstract] [Hide abstract]
ABSTRACT: Axonal regeneration after injury to the CNS is hampered by myelin-derived inhibitors, such as Nogo-A. Natural products, such as green tea, which are neuroprotective and safe for long-term therapy, would complement ongoing various pharmacological approaches. In this study, using nerve growth factor-differentiated neuronal-like Neuroscreen-1 cells, we show that extremely low concentrations of unfractionated green tea polyphenol mixture (GTPP) and its active ingredient, epigallocatechin-3-gallate (EGCG), prevent both the neurite outgrowth-inhibiting activity and growth cone-collapsing activity of Nogo-66 (C-terminal domain of Nogo-A). Furthermore, a synergistic interaction was observed among GTPP constituents. This preventive effect was dependent on 67-kDa laminin receptor (67LR) to which EGCG binds with high affinity. The antioxidants N-acetylcysteine and cell-permeable catalase abolished this preventive effect of GTPP and EGCG, suggesting the involvement of sublethal levels of H2O2 in this process. Accordingly, exogenous sublethal concentrations of H2O2, added as a bolus dose (5 μM) or more effectively through a steady-state generation (1-2 μM), mimicked GTPP in counteracting the action of Nogo-66. Exogenous H2O2 mediated this action by bypassing the requirement of 67LR. Taken together, these results show for the first time that GTPP and EGCG, acting through 67LR and elevating intracellular sublethal levels of H2O2, inhibit the antineuritogenic action of Nogo-A.This article is protected by copyright. All rights reserved.
Article: Green tea catechins potentiate the neuritogenic action of brain-derived neurotrophic factor: Role of 67-kDa laminin receptor and hydrogen peroxide[Show abstract] [Hide abstract]
ABSTRACT: Delivery of optimal amounts of brain-derived neurotrophic factor (BDNF) to regions of the brain affected by neurodegenerative diseases is a daunting task. Using natural products with neuroprotective properties, such as green tea polyphenols, would be a highly useful complementary approach for inexpensive long-term treatment of these diseases. In this study, we used PC12(TrkB) cells which ectopically express TrkB, a high affinity receptor for BDNF. They differentiate and induce neurite outgrowth in response to BDNF. Using this model, we show for the first time that treatment with extremely low concentrations (<0.1 μ g/ml) of unfractionated green tea polyphenols (GTPP) and low concentrations (<0.5 μ M) of their active ingredient, epigallocatechin-3-gallate (EGCG), potentiated the neuritogenic ability of a low concentration (2 ng/ml) of BDNF. A synergistic interaction was observed between GTPP constituents, where epigallocatechin and epicatechin, both individually lacking this activity, promoted the action of EGCG. GTPP-induced potentiation of BDNF action required the cell-surface associated 67kDa laminin receptor (67LR) to which EGCG binds with high affinity. A cell-permeable catalase abolished GTPP/EGCG-induced potentiation of BDNF action, suggesting the possible involvement of H2O2 in the potentiation. Consistently, exogenous sublethal concentrations of H2O2, added as a bolus dose (5 μ M) or more effectively through a steady-state generation (1 μ M), potentiated BDNF action. Collectively, these results suggest that EGCG, dependent on 67LR and H2O2, potentiates the neuritogenic action of BDNF. Intriguingly, this effect requires only submicromolar concentrations of EGCG. This is significant as extremely low concentrations of polyphenols are believed to reach the brain after drinking green tea.
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ABSTRACT: The protein kinase C (PKC) family of isoenzymes may be a crucial player in transducing H2O2-induced signaling in a wide variety of physiological and pathophysiological processes. PKCs contain unique structural features that make them highly susceptible to oxidative modification. Depending on the site of oxidation and the extent to which it is modified, PKC can be either activated or inactivated by H2O2. The N-terminal regulatory domain contains zinc-binding, cysteine-rich motifs that are readily oxidized by H2O2. When oxidized, the autoinhibitory function of the regulatory domain is compromised, and as a result, PKC is activated in a lipid cofactor-independent manner. The C-terminal catalytic domain contains several reactive cysteine residues, which when oxidized with a higher concentration of H2O2 leads to an inactivation of PKC. Here, we describe the methods used to induce oxidative modification of purified PKC isoenzymes by H2O2 and the methods to assess the extent of this modification. Protocols are given for isolating oxidatively activated PKC isoenzymes from cells treated with H2O2. Furthermore, we describe the methods used to assess indirect regulation of PKC isoenzymes by determining their cytosol to membrane or mitochondrial translocation and tyrosine phosphorylation of PKCδ in response to sublethal levels of H2O2. Finally, as an example, we describe the methods used to demonstrate the role of H2O2-mediated cell signaling of PKCɛ in green tea polyphenol-induced preconditioning against neuronal cell death caused by oxygen-glucose deprivation and reoxygenation, an in vitro model for cerebral ischemic/reperfusion injury.
Article: Unilateral Skill Acquisition Induces Bilateral NMDA Receptor Subunit Composition Shifts in the Rat Sensorimotor Striatum.[Show abstract] [Hide abstract]
ABSTRACT: The sensorimotor striatum is critical for the acquisition and consolidation of skilled learning-related motor sequences. Excitatory corticostriatal synapses undergo neuroplastic changes that impact signal transmission efficacy. Modification of N-methyl D-aspartate (NMDA) and α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor subunit composition and phosphorylation is critical for bidirectional experience-driven plasticity observed at these synapses. Metaplastic regulation of the ratio of NR2A to NR2B subunits of the NMDA receptor controls the threshold for the induction of subsequent plasticity. However, little is known about how repeated practice effects the differential regulation of glutamate receptors during the acquisition of a unilateral motor skill. Using immunoblot analysis, we assessed changes in NMDA and AMPA receptors during the associative stage of skill acquisition in synaptoneurosome preparations from the rat sensorimotor striatum. We found that the NR2A/B subunit ratio in the striatum contralateral to the trained limb decreased during skill acquisition optimizing the threshold for inducing subsequent synaptic plasticity during learning of the lateralized motor skill. In contrast, there was a significant increase in the NR2A/B subunit ratio in the ipsilateral striatum making the induction of subsequent plasticity more difficult. In addition, there was a selective decrease in AMPAR phosphorylation levels at serine site 831 but not 845 on the GluR1 subunit ipsilaterally with a trend toward a decrease contralaterally. These findings suggest that the successful acquisition of a lateralized motor skill necessitates the integration of motor programs in both striata, each of which reflects unique changes in the NR2A/B ratio that modulate the different task demands on the associated limb.
Article: Green Tea Polyphenols Precondition against Cell Death Induced by Oxygen-Glucose Deprivation via Stimulation of Laminin Receptor, Generation of Reactive Oxygen Species, and Activation of Protein Kinase Cϵ[Show abstract] [Hide abstract]
ABSTRACT: As the development of synthetic drugs for the prevention of stroke has proven challenging, utilization of natural products capable of preconditioning neuronal cells against ischemia-induced cell death would be a highly useful complementary approach. In this study using an oxygen-glucose deprivation and reoxygenation (OGD/R) model in PC12 cells, we show that 2-day pretreatment with green tea polyphenols (GTPP) and their active ingredient, epigallocatechin-3-gallate (EGCG), protects cells from subsequent OGD/R-induced cell death. A synergistic interaction was observed between GTPP constituents, with unfractionated GTPP more potently preconditioning cells than EGCG. GTPP-induced preconditioning required the 67-kDa laminin receptor (67LR), to which EGCG binds with high affinity. 67LR also mediated the generation of reactive oxygen species (ROS) via activation of NADPH oxidase. An exogenous ROS-generating system bypassed 67LR to induce preconditioning, suggesting that sublethal levels of ROS are indeed an important mediator in GTPP-induced preconditioning. This role for ROS was further supported by the fact that antioxidants blocked GTPP-induced preconditioning. Additionally, ROS induced an activation and translocation of protein kinase C (PKC), particularly PKCε from the cytosol to the membrane/mitochondria, which was also blocked by antioxidants. The crucial role of PKC in GTPP-induced preconditioning was supported by use of its specific inhibitors. Preconditioning was increased by conditional overexpression of PKCε and decreased by its knock-out with siRNA. Collectively, these results suggest that GTPP stimulates 67LR and thereby induces NADPH oxidase-dependent generation of ROS, which in turn induces activation of PKC, particularly prosurvival isoenzyme PKCε, resulting in preconditioning against cell death induced by OGD/R.
Article: Green tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: possible role of reactive oxygen species. J Neurosci Res[Show abstract] [Hide abstract]
ABSTRACT: Exogenously administered nerve growth factor (NGF) repairs injured axons, but it does not cross the blood-brain barrier. Thus, agents that could potentiate the neuritogenic ability of endogenous NGF would be of great utility in treating neurological injuries. Using the PC12 cell model, we show here that unfractionated green tea polyphenols (GTPP) at low concentrations (0.1 μg/ml) potentiate the ability of low concentrations of NGF (2 ng/ml) to induce neuritogenesis at a level comparable to that induced by optimally high concentrations of NGF (50 ng/ml) alone. In our experiments, GTPP by itself did not induce neuritogenesis or increase immunofluorescent staining for β-tubulin III; however, it increased expression of mRNA and proteins for the neuronal markers neurofilament-L and GAP-43. Among the polyphenols present in GTPP, epigallocatechin-3-gallate (EGCG) alone appreciably potentiated NGF-induced neurite outgrowth. Although other polyphenols present in GTPP, particularly epigallocatechin and epicatechin, lack this activity, they synergistically promoted this action of EGCG. GTPP also induced an activation of extracellular signal-regulated kinases (ERKs). PD98059, an inhibitor of the ERK pathway, blocked the expression of GAP-43. K252a, an inhibitor of TrkA-associated tyrosine kinase, partially blocked the expression of these genes and ERK activation. Antioxidants, catalase (cell-permeable form), and N-acetylcysteine (both L and D-forms) inhibited these events and abolished the GTPP potentiation of NGF-induced neuritogenesis. Taken together, these results show for the first time that GTPP potentiates NGF-induced neuritogenesis, likely through the involvement of sublethal levels of reactive oxygen species, and suggest that unfractionated GTPP is more effective in this respect than its fractionated polyphenols.
Article: A Direct Redox Regulation of Protein Kinase C Isoenzymes Mediates Oxidant-induced Neuritogenesis in PC12 Cells[Show abstract] [Hide abstract]
ABSTRACT: In this study, we have used the PC12 cell model to elucidate the mechanisms by which sublethal doses of oxidants induce neuritogenesis. The xanthine/xanthine oxidase (X/XO) system was used for the steady state generation of superoxide, and CoCl(2) was used as a representative transition metal redox catalyst. Upon treatment of purified protein kinase C (PKC) with these oxidants, there was an increase in its cofactor-independent activation. Redox-active cobalt competed with the redoxinert zinc present in the zinc-thiolates of the PKC regulatory domain and induced the oxidation of these cysteine-rich regions. Both CoCl(2) and X/XO induced neurite outgrowth in PC12 cells, as determined by an overexpression of neuronal marker genes. Furthermore, these oxidants induced a translocation of PKC from cytosol to membrane and subsequent conversion of PKC to a cofactor-independent form. Isoenzyme-specific PKC inhibitors demonstrated that PKCepsilon plays a crucial role in neuritogenesis. Moreover, oxidant-induced neurite outgrowth was increased with a conditional overexpression of PKCepsilon and decreased with its knock-out by small interfering RNA. Parallel with PKC activation, an increase in phosphorylation of the growth-associated neuronal protein GAP-43 at Ser(41) was observed. Additionally, there was a sustained activation of extracellular signal-regulated kinases 1 and 2, which was correlated with activating phosphorylation (Ser(133)) of cAMP-responsive element-binding protein. All of these signaling events that are causally linked to neuritogenesis were blocked by antioxidant N-acetylcysteine (both L and D-forms) and by a variety of PKC-specific inhibitors. Taken together, these results strongly suggest that sublethal doses of oxidants induce neuritogenesis via a direct redox activation of PKCepsilon.
Article: Variation in Galr1 expression determines susceptibility to excitotoxin-induced cell death in mice[Show abstract] [Hide abstract]
ABSTRACT: Inbred strains of mice differ in their susceptibility to excitotoxin-induced cell death, but the genetic basis of individual variation in differential susceptibility is unknown. Previously, we identified a highly significant quantitative trait locus (QTL) on chromosome 18 that influenced susceptibility to kainic acid-induced cell death (Sicd1). Comparison of susceptibility to seizure-induced cell death between reciprocal congenic lines for Sicd1 and parental background mice indicates that genes influencing this trait were captured in both strains. Two positional gene candidates, Galr1 and Mbp, map to 55 cM, where the Sicd1 QTL had been previously mapped. Thus, this study was undertaken to determine if Galr1 and/or Mbp could be considered as candidate genes. Genomic sequence comparison of these two functional candidate genes from the C57BL/6J (resistant at Sicd1) and the FVB/NJ (susceptible at Sicd1) strains showed no single-nucleotide polymorphisms. However, expression studies confirmed that Galr1 shows significant differential expression in the congenic and parental inbred strains. Galr1 expression was downregulated in the hippocampus of C57BL/6J mice and FVB.B6-Sicd1 congenic mice when compared with FVB/NJ or B6.FVB-Sicd1 congenic mice. A survey of Galr1 expression among other inbred strains showed a significant effect such that 'susceptible' strains showed a reduction in Galr1 expression as compared with 'resistant' strains. In contrast, no differences in Mbp expression were observed. In summary, these results suggest that differential expression of Galr1 may contribute to the differences in susceptibility to seizure-induced cell death between cell death-resistant and cell death-susceptible strains.
Article: Intrastriatal dopamine D1 antagonism dampens neural plasticity in response to motor cortex lesion[Show abstract] [Hide abstract]
ABSTRACT: Motor cortex lesions in rats partially denervate the striatum, producing behavioral deficits and inducing reactive neuroplasticity. Plastic responses include changes in growth-associated protein marker expression and anatomical restructuring. Corticostriatal plasticity is dependent on dopamine at the striatal target, where D1 receptor signaling reinforces behaviorally relevant neural activity. To determine whether striatal dopamine D1 receptor signaling is important for the growth-associated protein responses and behavioral recovery that follow unilateral motor cortex aspiration, the dopamine D1 receptor antagonist SCH23390 was intrastriatally infused in cortically lesioned animals. After a cortical aspiration lesion in Long Evans rats, the growth-associated proteins SCG10 and GAP-43 were upregulated in the cortex contralateral to the lesion at 30 days post-lesion. However, continuous unilateral intrastriatal infusion of SCH23390 prevented this aspiration-induced upregulation. Furthermore, lesioned rats demonstrated spontaneous sensorimotor improvement, in terms of limb-use symmetry, about 1 month post-lesion. This improvement was prevented with chronic intrastriatal SCH23390 infusion. The D1 receptor influence may be important to normalize corticostriatal activity (and observable behavior), either in a long-term manner or temporarily until other more permanent means of synaptic regulation, such as sprouting or synaptogenesis, may be implemented.
Article: Differential regulation of the growth-associated proteins GAP-43 and superior cervical ganglion 10 in response to lesions of the cortex and substantia nigra in the adult rat[Show abstract] [Hide abstract]
ABSTRACT: Investigation of the elements underlying synapse replacement after brain injury is essential for predicting the neural compensation that can be achieved after various types of damage. The growth-associated proteins superior cervical ganglion-10 and growth-associated protein-43 have previously been linked with structural changes in the corticostriatal system in response to unilateral deafferentation. To examine the regulation of this response, unilateral cortical aspiration lesion was carried out in combination with ipsilateral 6-hydroxydopamine lesion of the substantia nigra, and the time course of the contralateral cortical molecular response was followed. Unilateral cortical aspiration lesion in rats corresponds with an upregulation of superior cervical ganglion-10 mRNA at 3 and 10 days post-lesion, and protein, sustained from three to at least 27 days following lesion. With the addition of substantia nigra lesion, the response shifts to an upregulation of growth-associated protein-43 mRNA at 3 and 10 days post-lesion, and protein after 10 days. Nigral lesion alone does not alter contralateral expression of either gene. Likewise, motor function assessment using the rotorod test revealed no significant long-term deficits in animals that sustained only nigrostriatal damage, but cortical lesion was associated with a temporary deficit which was sustained when nigrostriatal input was also removed. Growth-associated protein-43 and superior cervical ganglion-10, two presynaptic genes that are postulated to play roles in lesion-induced sprouting, are differentially upregulated in corticostriatal neurons after cortical versus combined cortical/nigral lesions. The shift in contralateral gene response from superior cervical ganglion-10 to growth-associated protein-43 upregulation and associated behavioral deficit following combined cortical and nigral denervation suggest that nigrostriatal afferents regulate cortical lesion-induced gene expression and ultimate functional outcome.
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ABSTRACT: Defining the selective pattern of synapse replacement that occurs in different areas of the damaged brain is essential for predicting the limits of functional compensation that can be achieved after various types of brain injury. Here we describe the time course of dendritic reorganization, spine loss and recovery, and synapse replacement in the striatum following a unilateral cortex ablation. We found that the time course for the transient loss and recovery of dendritic spines on medium spiny I (MSI) neurons, the primary postsynaptic target for corticostriatal axons, paralleled the time course for the removal of degenerating axon terminals from the neuropil and the formation of new synapses on MSI neurons. Reinnervation of the deafferented striatum occurred chiefly by axon terminals that formed asymmetric synapses with dendritic spines of MSI neurons, and the mean density of asymmetric synapses recovered to 86% of the sham-operated rat value by 30 days postlesion. In addition, the synaptic circuitry of the reconstructed striatum was characterized by an increase in the number of multiple synaptic boutons (MSBs), i.e., presynaptic axon terminals that make contact with more than one dendritic spine. Whether the postsynaptic contacts of MSBs are formed with the dendritic spines of the same or a different parent dendrite in the striatum is unknown. Nevertheless, these data suggest that the formation of MSBs is an essential part of the compensatory response to the loss of input from the ipsilateral cortex following the aspiration lesion and may serve to modulate activity-dependent adaptive changes in the reconstructed striatum that can lead to functional recovery.
Article: Alterations in Rat Striatal Glutamate Synapses Following a Lesion of the Cortico- and/or Nigrostriatal Pathway[Show abstract] [Hide abstract]
ABSTRACT: Ultrastructural changes within the ipsilateral dorsolateral striatum were investigated 1 month following a unilateral ablation of the rat frontal cortex (CTX), removing corticostriatal input, or injection of the neurotoxin, 6-hydroxydopamine (6-OHDA), into the substantia nigra pars compacta, removing nigrostriatal input. In addition, a combined ipsilateral cortical and 6-OHDA lesion (CTX/6-OHDA) was carried out. We find that following a CTX, 6-OHDA, or CTX/6-OHDA lesion, there was a significant decrease in the density of striatal nerve terminal glutamate immunoreactivity compared to the control group. There was also a significant increase in all three lesion groups in the mean percentage of asymmetrical synapses associated with a perforated postsynaptic density. There was a large increase within the CTX/6-OHDA-lesioned group and a smaller but still significant increase in the CTX-lesioned group in the percentage of terminals or boutons with multiple synaptic contacts (i.e., multiple synaptic boutons, MSBs), compared to either the 6-OHDA or the control group. There was no change in any of these measurements within the contralateral striatum. There was a significant decrease in the number of apomorphine-induced contralateral rotations in the CTX/6-OHDA versus the 6-OHDA-lesioned group. Animals receiving just the single CTX or 6-OHDA lesion recovered in motor function compared to the control group as measured by the Rotorod test, while the CTX/6-ODA-lesioned group recovered to less than 50% of the control level. The data suggest that following a CTX and/or 6-OHDA lesion, there is an increase in striatal glutamatergic function. The large increase in the percentage of MSBs in the combined lesion group suggests that dopamine or other factors released by the dopamine terminals assist in regulating synapse formation.
Article: Annotation technology[Show abstract] [Hide abstract]
ABSTRACT: Annotation Technology is a systematized set of recommendations for design of successful advanced annotation software covering the architectural, functional and user-interface aspects. It is grounded in a careful examination of 17 existing systems accompanied by our own empirical study of annotation types, applications and desired functionality. To validate the recommendations of Annotation Technology, we have also developed Annotator, a system for making on-line annotations on arbitrary hypertext documents. Annotator offers some capabilities unavailable in existing systems. It has a proxy-based architecture for annotating documents over the web and sorting the comments in an annotation database.
Article: Differential regulation of the growth associated proteins GAP-43 and SCG-10 in response to unilateral cortex ablation in adult rats[Show abstract] [Hide abstract]
ABSTRACT: Synapse replacement after brain injury has been widely documented by anatomical studies in various parts of both the developing and adult nervous system. However, the molecular events that define the specificity of the empirically derived rules of reactive synaptogenesis in different regions of the adult brain remain unclear. In this study we examined the differential regulation of the lesion-induced response of the two growth-associated proteins, superior cervical ganglia-10 and growth-associated protein-43, after unilateral cortex ablation, and determined a hierarchical order for the lesion response from remaining afferent projection neurons originating from the contralateral cortex, ipsilateral thalamus and substantia nigra. We report that in response to unilateral cortex ablation both messenger RNA, by northern blot, and protein, by western blot, for superior cervical ganglia-10 but not growth-associated protein-43 was increased in the homologous area of the contralateral cortex but not the ipsilateral thalamus or substantia nigra. In addition, the specificity of the superior cervical ganglia-10 response, assessed by combined in situ hybridization and retrograde FluoroGold labeling of striatal afferent neurons, found that superior cervical ganglia-10 messenger RNA was increased prominently in layer V pyramidal neurons of the contralateral corticostriatal pathway but was unchanged in afferent projection neurons from the thalamus and substantia nigra. Furthermore, the increase in both superior cervical ganglia-10 messenger RNA and protein seen at three days postlesion in contralateral corticostriatal neurons coincides in time with the initiation of neurite outgrowth in the deafferented striatum by contralateral corticostriatal axons described in our previous ultrastructural study. However, if cortical input to the striatum was removed bilaterally the lesion-induced response for superior cervical ganglia-10 messenger RNA shifted secondarily to thalamostriatal neurons in the ipsilateral thalamus. These data provide evidence that superior cervical ganglia-10 and growth-associated protein-43 are differentially regulated in neurons of the contralateral corticostriatal pathway in response to unilateral cortex ablation and suggests that superior cervical ganglia-10 plays a role in the regulation of neurite outgrowth in the adult striatum after brain injury. However, the specific role that superior cervical ganglia-10 may play in reactive synaptogenesis remains unclear. In addition, our data suggest that a hierarchical order exists for the reinnervation of deafferented striatal neurons after unilateral cortex ablation with preference given to homologous axons from the contralateral cortex.
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ABSTRACT: Synaptic replacement in rat striatum following a unilateral cortical lesion was investigated using electron microscopy and the anterograde tracer, biotinylated dextrin amine (BDA). In the deafferented striatum evidence of axon sprouting and synapse replacement was seen at 20 days after the lesion and most newly-formed axon terminals were labeled with BDA injected previously into the contralateral cortex. In addition, BDA-labeled fibers from the contralateral cortex formed multiple asymmetric axospinous synapses with deafferented striatal neurons, a morphological feature rarely seen in unlesioned rats. These data suggest that in response to a unilateral cortex lesion axons from the contralateral cortex sprout and reinnervated the deafferented striatal neurons and that reinnervation by 'like' afferents maybe crucial for the establishment of functional recovery after the unilateral cortex lesion.
Article: The mRNA encoding VGF, a neuronal peptide precursor, is rapidly regulated in the rat central nervous system by neuronal activity, seizure, and lesion[Show abstract] [Hide abstract]
ABSTRACT: The VGF gene encodes a neuronal secretory-peptide precursor that is rapidly induced by neurotrophic growth factors and by depolarization in vitro. VGF expression in the animal peaks during critical periods in the developing peripheral and central nervous systems. To gain insight into the possible functions and regulation of VGF in vivo, we have used in situ hybridization to examine the regulation of VGF messenger RNA by experimental manipulations, and have found it to be regulated in the CNS by paradigms that affect electrical activity and by lesion. Inhibition of retinal electrical activity during the critical period of visual development rapidly repressed VGF messenger RNA in the dorsal lateral geniculate nucleus of the thalamus. In the adult, kainate-induced seizures transiently induced VGF messenger RNA in neurons of the dentate gyrus, hippocampus, and cerebral cortex within hours. Cortical lesion strongly induced VGF messenger RNA in ipsilateral cortex within hours, and strongly repressed expression in ipsilateral striatum. Ten days postlesion there was a delayed induction of VGF messenger RNA in a portion of deafferented striatum where compensatory cortical sprouting has been detected. Expression of the neuronal secretory-peptide precursor VGF is therefore modulated in vivo by monocular deprivation, seizure, and cortical lesion, paradigms which lead to neurotrophin induction, synaptic remodeling and axonal sprouting.
Article: Differential Regulation of Astrocytic mRNAs in the Rat Striatum after Lesions of the Cortex or Substantia Nigra[Show abstract] [Hide abstract]
ABSTRACT: This study evaluates the time course of expression of three astrocytic mRNAs, glial fibrillary acidic protein (GFAP), apolipoprotein E (ApoE), and clusterin, in the rat striatum (ST) following a unilateral lesion of either the cortex (CX) or the substantia nigra (SN), using Northern blot and in situ hybridization analyses. We found that while there was a time-dependent increase in astrocytic GFAP mRNA in the deafferented ST following both the CX and the SN lesions, the time course of the response was different between the two lesion paradigms. Specifically, the increase in GFAP mRNA in striatal astrocytes after the SN lesion was rapid and transient returning to control levels by 10 days postlesion, while the response was long lasting and remained increased until at least 27 days after the CX lesion. In addition, the mRNA response for both ApoE and clusterin was differentially regulated in response to the two lesions. Specifically, both clusterin and ApoE mRNAs were rapidly increased in the ST following the CX lesion while both mRNAs remained unchanged following the SN lesion. Data from this study extend information derived from previous investigations on the multifunctional role of astrocytes in the response to brain injury. Specifically, our data support the notion that while the time course of the GFAP response in striatal astrocytes may vary between lesion paradigms, the upregulation of GFAP is part of a generalized response of reactive astrocytes to diverse brain injuries. By comparison, upregulation of the mRNAs for the lipoproteins clusterin and ApoE are lesion specific and may play a role in the transport of recycled myelin lipids from dying axons to actively growing axons and dendrites in reactive synaptogenesis.
Article: Upregulation of stathmin (p19) gene expression in adult rat brain during injury-induced synapse formation[Show abstract] [Hide abstract]
ABSTRACT: Stathmin (p19) is developmentally regulated as a neural-enriched phosphoprotein associated with neurite outgrowth and synaptic formation during cell proliferation and differentiation, and remains highly abundant in adult rat brain. Whether stathmin is involved in injury-induced reactive synaptogenesis in adult rat was examined in this study. Following unilateral cortical lesion, a significant increase in stathmin mRNA expression was found in the cells of contralateral homotypic cortex and in the subventricular zone of the lateral ventricle. This increase coincided in time with the corticostriatal axon sprouting and synaptic remodeling previously found in denervated striatum. Our data suggest that stathmin plays an important role in regulation of reactive synaptogenesis in adult brain.
Article: Cheng HW, Rafols JA, Goshgarian HG, Anavi Y, Tong J, McNeill TH. Differential spine loss and regrowth of striatal neurons following multiple forms of deafferentation: a Golgi study. Exp Neurol 147: 287-298[Show abstract] [Hide abstract]
ABSTRACT: Golgi-Cox method and morphometric analyses were used to study the plasticity of striatal medium spiny I neurons in 6-month-old C57BL/6N mice after unilateral or bilateral lesion of the cerebral cortex or combined lesions of the ipsilateral cerebral cortex and intralaminar thalamus. In adult mouse, unilateral lesions of the cerebral cortex did not result in a net gain or loss of linear dendritic length in a randomly selected population of striatal medium spiny I neurons. In addition, there was a well-defined time course of striatal spine loss and replacement occurring after a unilateral cortical lesion. By day 3 postlesion the average 20-microm dendritic segment had lost 30% of the unlesioned control spine value, reached its nadir, lost 45.5%, at 10 days postlesion, and recovered to 80% of unlesioned control levels by 20 days postlesion. The recovery of spines was blocked by a secondary lesion on the contralateral cortex but not on the ipsilateral intralaminar thalamus. These data suggest that striatal medium spiny I neurons of adult mice have a remarkable capacity for plasticity and reactive synaptogenesis following a decortication. The recovery of spine density is primarily induced by axonal sprouting of survival homologous afferent fibers from the contralateral cortex.
Article: Age-related change in short-term synaptic plasticity intrinsic to excitatory striatal synapses[Show abstract] [Hide abstract]
ABSTRACT: Aging disrupts the expression of synaptic plasticity in many central nervous system (CNS) structures including the striatum. We found age differences in paired-pulse plasticity to persist at excitatory striatal synapses following block of gamma aminobutyric acid (GABA)A and GABA(B) receptors, a property that was independent of the number of afferents activated. High Mg2+/low Ca2+ artificial cerebral spinal fluid (ACSF) reduced release probability and consequently the size of the evoked excitatory post-synaptic potential (EPSP). High Mg2+/low Ca2+ ACSF also increased the expression of paired-pulse facilitation and eliminated the age difference seen previously in normal ACSF. These data suggest that age differences in paired-pulse plasticity reflect an alteration in release probability at excitatory striatal synapses. In support of this hypothesis, we found age differences in another presynaptic form of plasticity referred to as synaptic augmentation. Examination of the synaptic depression that developed during the conditioning tetanus also revealed an age-related increase in synaptic depression. These data indicate that age-related changes in facilitation may be due in part to a reduction in the readily releasable pool of synaptic vesicles. Dendritic structure (spine density and dendritic length) was correlated with short-term synaptic plasticity, but these relationships depended upon the variance associated with age (hierarchical regression). Post-hoc within-age group regressions demonstrated relationship between spine density and paired-pulse plasticity. No other age-specific correlations were found. These findings imply an age-dependent association between altered dendritic morphology and changes in synaptic plasticity.
Top Journals
- Neuroscience (9)
- Brain Research (8)
- Experimental Neurology (5)
- Neurobiology of Aging (4)
- Cell and Tissue Research (4)
University of Southern California
Los Angeles, California, United States
- • Department of Cell and Neurobiology
- • Keck School of Medicine
- • Department of Neurology
- • Department of Biological Sciences
University of California, Los Angeles
Los Ángeles, California, United States
- Department of Neurology
Keck School of Medicine USCLos Ángeles, California, United States
University of Rochester
Rochester, New York, United States
- • Department of Neurology
- • Department of Neurobiology and Anatomy
- • School of Medicine and Dentistry
- • Division of Hospital Medicine
Monroe Community CollegeRochester, New York, United States
University Center Rochester
Rochester, Minnesota, United States
- Department of Neurology
Colorado State University
Fort Collins, Colorado, United States
- College of Veterinary Medicine and Biomedical Sciences


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Publications (2)0 Total impact
Conference Paper: A novel intelligent system for analysis and recognition of power quality disturbance signal[Show abstract] [Hide abstract]
ABSTRACT: The power quality disturbances and the resulting problems have emerged as an important research. The power system industries with sensitive electrical loads have become more dependent on the quality of power supply system. The power quality disturbances analysis is becoming an essential issue because of the widespread use of electronic nonlinear loads that have affected the operation of distributed power system network in residential and industrial areas. A novel approach to detect and locate short duration disturbance in distributed power system combing neural network is presented. The paper tries to explain to investigate feature extraction of transient signal and to analyze the disturbance signal. The feature information obtained from wavelet decomposition coefficients acts as input vector of wavelet network for power quality disturbance pattern recognition. The power quality disturbance recognition performance is completed and the improved back-propagation algorithm is used to fulfill the network parameter initialization. By means of simulation data training, the disturbance pattern can be obtained from the trained wavelet network output. The simulation results and analysis indicate that the wavelet transform combining with neural network is sensitive to transient signal singularity detection.
Conference Paper: Information processing in digital holographic imaging and measurement[Show abstract] [Hide abstract]
ABSTRACT: According to Fresnel diffraction theory, the principles of imaging and shape measurement are analyzed concisely. The model of phase aberration in numerical reconstruction is built. The zero-order diffraction and unwanted first-order image can be removed by using frequency filtering. Based on lensless Fourier transform digital holographic setup, the experiment is conducted by using a US Air Force test target as microscopic object. The accurate phase image is obtained by combining the automatic procedure for phase aberration compensation with manual adjustment of reconstructing parameters. The lateral resolution of the intensity image of 3.10mum without any pre-magnification is demonstrated experimentally, and higher resolution of phase image has been achieved. The results show that in the case of strong noise, the inexact reconstruction parameters can be gained only by the automatic procedure. In order to obtain the accurate phase information, the finer manual adjustment is necessary subsequently. It is the committed step that recording high quality digital hologram in digital holography.
Top Journals
Hebei University of EngineeringHan-tan-shih, Hebei, China


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WASHINGTON -- It is a lineup generous in its moderation, astonishing for its continuity, startling for its stability.
A secretary of defense, Robert Gates, who once headed the George Bush School of Government and Public Service at Texas A&M. A secretary of state, Hillary Clinton, who supported the invasion of Iraq, voted to label the Iranian Revolutionary Guard a terrorist organization and called direct, unconditional talks with Iran "irresponsible and frankly naive." A national security adviser, retired Gen. James Jones, most recently employed at the U.S. Chamber of Commerce, who served as a special adviser to the Bush administration on the Middle East. A secretary of the Treasury, Timothy Geithner, who is one of Henry Paulson's closest allies outside the administration. A head of the Council of Economic Advisers, Christina Romer, whose writings and research seem to favor low tax rates, stable money and free trade.
It is tempting for conservatives to crow -- or liberals to lament -- that Barack Obama's victory has somehow produced John McCain's administration. But this partisan reaction trivializes some developments that, while early and tentative, are significant.
First, these appointments add evidence to a debate about the political character of the president-elect himself. Conservatives have generally feared that Obama is a closet radical. He has uniformly voted with liberal interests and done nothing to justify a reputation for centrism.
Until now. Obama's appointments reveal not just moderation but maturity -- magnanimity to past opponents, a concern for continuity in a time of war and economic crisis, a self-confidence that allows him to fill gaps in his own experience with outsized personalities, and a serious commitment to incarnate his rhetoric of unity.
All the normal caveats apply. It is still early. Obama is benefiting from being the only player on the stage -- all his pretensions of moderation could be quickly undermined by a liberal Congress, unhinged by its expanded majority. And Obama's social liberalism could still turn Washington into a culture-war battlefield.
But honesty requires this recognition: So far, Barack Obama has the instincts and ambitions of a large political figure.
Bernie Sanders Champions YUGE Profits for U.S. Corporations (But Only in Cahoots with Communists) | Humberto Fontova
Bush mocks Rubio and his fans: Stop whining that it's "unfair" that you're being attacked by another candidate's Super PAC | Allahpundit


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2014 remake - Girl Power +VIDEO+ by ayacinthWatch
©2014-2016 ayacinth
Old image:
Speedpaint video: www.youtube.com/watch?v=OIa9g6…
its super fun seeing yourself improve ;v;
Speedpaint video: www.youtube.com/watch?v=OIa9g6…
its super fun seeing yourself improve ;v;
This is excellent!
Cute X3
*spits out tea* You drew this?! I saw it on YT!
I have seen the video, it's looks amazing!
Gosh, you made her so pretty, I love her eyes and your shading style !
Fun indeed. This picture turned out great!
The lighting is absolutely gorgeous! The moon looks great and you did a wonderful job having the light escape around the edges of Rouge. The Chaos Emerald in her hand sparkles marvelously too! The pose, of course, fits Rouge to a tee.
Thank you for letting us feature this in our gallery at the S-S-S-S-S-Squad! If you are interested, we are running our second contest right now.
Really cool. Nice work here
Its sooo glowy and lovely!
Beautiful ☆
Wooow, love the remake. The use of the moonlight came out amazing, Great work!
So amazing and sexy!
it was simply amazing
This newer picture you've done of Rouge looks very nice and lovely as usual, my friend.
Beautiful piece
I'm so jealous T^T
Very beautiful
;U;..... is so amazing....
woo ....your style has improved a lot....
wow very stunning I can see how much you've improved good job!!
Your shading is absolutely amazing.


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Wide Receiver
Height: 5-foot-10
Weight: 175 pounds
Class Year: RS SR
Hometown: Cameron, TX
Prior School: New Mexico State
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The Latest: Player profile: Brandon Freeman — 8/7/2014
Kam Jones gets most of the publicity at wide receiver, but senior Brandon Freeman is poised for a huge season.[details]
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Originally posted on Rockies Review | Last updated 4/13/13
Fowler has been a huge surprise.Who is this guy?Dexter Fowler, suddenly a guy more fitting of the cleanup role, launched two home runs on Friday night, both of which came when the game was tied, helping the Rockies to a 7-5 victory at Petco Park in San Diego.It defies reality. Fowler has always been talented. He was one of the most highly touted prospects in Rockies history. However, he wasn't highly thought of because of his power. The skinny center fielder was known for his speed, for his defense, and overall athleticism. He was never thought of as a guy who would hit for power.Both home runs were absolutely crushed. The 9th inning home run off of Huston Street was to the deepest part of the park, well into the night when it is nearly impossible to hit a ball out of Petco Park. In fact, the ball was hit so hard, there was no doubt that it was leaving the yard.What is baffling is that Fowler's power is coming from the left side of the plate. Less than two years ago, there were plen...
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Jaromir Jagr has experienced plenty in his 41 years of life, but he wasn't sure he'd ever missed two games because of the flu before.
With the "strongest flu" of his life last week, Jagr missed both weekend games against the Capitals and Senators before getting back onto the Bruins practice ice on Tuesday morning. It actually hit him earlier in the week and he played through it in the games against the Flyers and Lightning before finally agreeing to shut it down for the final two games.
"I feel like [expletive], man," said Jagr. "It's the strongest flu I've ever had. I couldn't do anything."
While it's of some concern that the right wing still isn't feeling 100 percent with Game 1 of the playoffs against the Toronto Maple Leafs set for Wednesday night at TD Garden, it's expected that Jagr will be back on the third line with Chris Kelly. It's still up in the air whether it will be Kaspars Daugavins, Rich Peverley or Carl Soderberg potentially skating with them.
"I think Jags is over the flu, so he should be OK," said Claude Julien. "We've had some new faces coming in, Soderberg and then Jags ...Daugavins. We've been inserting them in different areas. We know that [Jagr] is a player that we want in our lineup, but he's missed the last couple of games with flu-like symptoms.
"We would have like to see him play two more games and familiarize himself with our team, but that wasn't the case. Is it a challenge? It's a bit of a challenge, but I don't think there's any need to see it as a disadvantage."
On the contrary, Jagr was working in a power-play unit with Zdeno Chara, Tyler Seguin, Patrice Bergeron and Milan Lucic at practice, and showing off the elite skills and rare size and strength that have allowed him to put up nine points (2 goals, 7 assists) in 11 games since being traded to Boston.
Now it's time for Jagr to rest up, shake off the flu residue and show everybody in Boston what playoff playmaking is all about.
Jagr back on the ice, ready for B's playoff opener
Jaromir Jagr has experienced plenty in his 41 years of life, but he wasn't sure he'd ever missed two games because of the flu before.


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American English: /ˈlɛft ˈˌwɪŋər/, /ˈlɛf(t)ˈˌwɪŋər/British English: /ˌlɛftˈwɪŋə/
Translation of left-winger in Spanish:
- 2 (Sport)extremo (masculine or feminine) izquierdo
alero (masculine or feminine) izquierdo
Definition of left-winger in:
- British & World English dictionary
- US English dictionary
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Mexican-Inspired Turkey Burgers Recipe
4.5 13
We love burgers on the grill, but turkey burgers can be bland and beef burgers can be fatty. To create these burgers, I used a spice combination from a taco recipe and then tinkered with cheeses and different toppings. —Heather Byers, Pittsburgh, Pennsylvania
- 1/2 cup salsa, divided
- 1/4 cup shredded reduced-fat cheddar cheese
- 3 teaspoons paprika
- 1 teaspoon dried oregano
- 1 teaspoon ground cumin
- 3/4 teaspoon sugar
- 3/4 teaspoon garlic powder
- 1/2 teaspoon dried thyme
- 1/4 teaspoon salt
- 1/4 teaspoon cayenne pepper
- 1 pound extra-lean ground turkey
- 1/4 cup reduced-fat sour cream
- 4 hamburger buns, split
- 1/2 cup torn curly endive
- 1 medium tomato, chopped
- In a large bowl, combine 1/4 cup salsa, cheese, paprika, oregano, cumin, sugar, garlic powder, thyme, salt and cayenne. Crumble turkey over mixture and mix well. Shape into four burgers.
- Moisten a paper towel with cooking oil; using long-handled tongs, lightly coat the grill rack. Grill, covered, over medium heat or broil 4 in. from the heat for 5-7 minutes on each side or until a thermometer reads 165° and juices run clear.
- In a small bowl, combine sour cream and remaining salsa. Place burgers on buns; top with endive, tomato and sour cream mixture. Yield: 4 servings.
Originally published as Mexican-Inspired Turkey Burgers in Healthy Cooking April/May 2008, p33
Medium-Bodied Red Wine
Enjoy this recipe with a medium-bodied red wine such as Chianti, Sangiovese, Malbec or Zinfandel.
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Kay and Robert Bertl celebrated their 50th wedding anniversary at the Santa's Lodge Celebration Room April 2 with family and friends.
The dinner was hosted by their children, Brooks Bertl and his wife, Melinda, Jaynie Ellis, and Victor Bertl.
The couple were married April 1, 1961, at the First Baptist Church in Anderson. The Rev. Melvin Phillips officiated the ceremony.
To keep the birthday list updated, The Perry County News needs your help. Call 547-3424 if you want to add a name, make a change or if a name or date is wrong. If a person is deceased, please advise the newspaper so the name can be removed from the list. This information is appreciated. You can add names for the year if you like.
April 15
Ethan Thomas Greulich
Adam and Sarah Greulich announce the birth of their son, Ethan Thomas Greulich, March 7, 2011, at Hancock Regional Hospital in Greenfield.
The infant weighed 7 pounds, 10 ounces and was 21 inches long.
Ethan has one older brother, Nolan.
Grandparents are Alan and Theresa Lance of Uniondale, Kermit Greulich of Ferdinand and the late Ramona Walker and Debbie Greulich.
Holy Week, Easter schedule at Archabbey
ST. MEINRAD – The Holy Week and Easter services for Saint Meinrad Archabbey has been scheduled. The public is invited to join the Benedictine monks for these services in the Archabbey Church. All times are Central.
Palm Sunday, April 17: 9:15 a.m., Blessing and procession with palms, followed by Mass; 5 p.m., Vespers.
Holy Thursday, April 21: 5 p.m., Mass of the Lord's Supper; no Vespers.
Good Friday, April 22: 3 p.m., Liturgy of the Passion and Death of the Lord.
CANNELTON – The Cannelton Freewill Baptist Church in Cannelton will host several activities next week leading up to Easter.
Open communion and feet washing for anyone of the Christian faith will be held Thursday, April 21 at 7 p.m.
TELL CITY – A two-hour session has been planed from 9:30 to 11:30 a.m. Saturday to explain ways to neither minimize nor maximize the loss of a loved one, but to see it as a journey and grief as a process.
The event, sponsored by Huber Funeral Home and Zoercher-Gillick Funeral Home, will be held at the Catholic Ministry Center, Room 10, located on Jefferson St., in Tell City.
Sister Katheryn Huber, OSB will be presenting the program.
The public is invited to attend and coffee, juice and doughnuts will be served.
Sydney Goffinet of Branchville served as a page for Sen. Richard Young March 29.
Goffinet, 14 met Young, and gained a firsthand look at how the legislative process works during her time at the Statehouse. Students ages 12-18 are eligible to serve for one day assisting with various legislative activities including running errands within the Statehouse, delivering messages and helping with a variety of other tasks.
FERDINAND – The annual Ferdinand Herb and Garden Days will be held Friday, Saturday and Sunday with various activities throughout the days.
Shops throughout town will have herbs, perennials, hanging baskets, annuals, ferns, landscape and bedding plants, primitives, antiques, home and garden décor, patio, gardening seminars, arts and crafts markets and food available.
LEOPOLD – Jon Suhrheinrich and Andy Connor of Boy Scout Troop 191 received their Eagle Scout awards Sunday March 27, at the St. Augustine Church in Leopold.
Suhrheinrich is the son of Brian and Kathy Suhrheinrich of St Croix. Connor is the son of Rick and Arleela Connor of Leopold.
Connor's Eagle Scout leadership project was to erect a flagpole and perform landscaping and maintenance at the Leopold Park.
Students of North Perry Head Start visited Oakwood Health Campus April 7 to perform plays and sing songs for residents. Children acted out well-known stories about a farmer and the turnip, the three little pigs and the big bad wolf and the three billy goats gruff. After their performances, students visited with residents and shared punch and cookies.
Copyright © 2016
The Perry County News is your source for local news, sports, events, and information in Perry County, Indiana, and the surrounding area.


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Version: 1.3
A WordPress plugin for small performing groups for listing shows and associated actors.
By: Ando Roots and Peep Pullerits.
Allows any comedian or venue to embed their schedule and sell comedy tickets on their WordPress website or blog
By: Ankit Chaudhary, Nasi Peretz, Scot Richardson, and LaughStub.
RSS link for this tag.


text: п»ї Emshwiller, Ed, 1925-1990 - Library Catalogue - The Licia & Mason Beekley Community Library Library policies Library hours Library catalogue More than 10,000 books in the database! Library Catalogue » Emshwiller, Ed, 1925-1990 A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z In the Cards written by "Emshwiller, Ed, 1925-1990" ... found out. Still, you know how tactless some people can be. Marge just shook her head and went right on sobbing. "Listen," I said, "I'll bet you're getting all worked up for nothing. ... read more The Tunnel Under The World written by "Emshwiller, Ed, 1925-1990" ...mitations at all. Put a dozen copies of him into a plant and they will run it all, twenty-four hours a day, seven days of every week, never tiring, never overlooking anything, never forgetting...... read more World Without War written by "Emshwiller, Ed, 1925-1990" ...in appearance. It was a peaceful, contemplative scene. Jennette snuggled up against Mark, thoughtfully tracing a design with fruit juice on his arm. "This is fun," she said softly. "So much more ... read more Navigation 01. About Us 02. Library Catalogue 03. Library Hours 04. Library Policies 05. Happenings and Special Events 06. Databases and Online Catalogs 07. BookFriends 08. Summer Reading Club 09. Contacts Favorites Authors 01. Campen, M. H. Van, 1874-194202. Cootes, F. Graham03. Cust, Henry John Cockayne, 1861-191704. Stern, Menco05. Record, Robert, 1510?-155806. Hopkins, Gerard Manley, 1844-1889?07. Hersey, Harold, 1893-196408. Couperus, Louis, 1863-192309. Jewett, Sarah Orne, 1849-190910. Leipoldt, Christiaan Louis, 1880-1947see all authors Partner Links Home page | About Us | Library Catalogue | Library Hours | Library Policies | Contacts All rights reserved. Public library. 2012. Privacy policy


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On my system, i am using eclipse ganymede version along the Android SDK and ADT plugin installed. I have created an android AVD (target android 1.5) with 512MB of memory. Its quite frustrating to see the slow boot up of it. It takes around 4-5 mins to complete its boot-up. Is there any way or tweak to speed up this boot up process.
PC config:
P4 2.4 Ghz with 1 GB ram.


text:
I'm using WP 3.3.2 and Admin Menu Editor Version 1.1.6. I get the "Failed to decode input! The menu wasn't modified." error whenever I try to edit anything. I've disabled all other plugins and have switched to the Twenty Twelve theme to see if there's a conflict and, nope, that's not it.
Any help you can pass along would be appreciated!


text:
Just one week to go and we are so excited here at Fem Jam HQ in Leeds!!
We just have a few little announcements to make.
Unfortunately (and we are really sad about this) due to unforeseen circumstances, Education For Choice will no longer be at Student Feminist Jamboree 2014. Keep an eye out for any of their events coming up this year. We <3 EFC
Also, the deadline for accommodation requests is this Tuesday. If you haven't signed up by then, we can't guarantee you free accommodation, so get in touch ASAP!
Lots of love x


text:
realmagick.com The shrine of knowledge.
Cairns Queensland Transport
A selection of articles related to cairns queensland transport.
Original articles from our library related to the Cairns Queensland Transport. See Table of Contents for further available material (downloadable resources) on Cairns Queensland Transport.
- Bringing it Down to Earth: A Fractal Approach
- 'Clouds are not spheres, mountains are not cones, coastlines are not circles, and bark is not smooth, nor does lightning travel in a straight line.' B. Mandelbrot W e want to think about the future - it's our nature. Unlike other creatures, humans possess an...
Mystic Sciences >> Astrology
- Ehwaz
- The third rune of the third aett bears the reconstructed Common Germanic name Ehwaz. Later, its name became Aihws in Gothic (note how archaic Gothic is), and still later, Eh in Anglo-Saxon. If you remember that "k" in Indo-European changed to "h" in Germanic,...
Divination >> Rune Stones
- Mercury
- Planet: Mercury Signs: Gemini and Virgo Day: Wednesday The quickest planet of our solar system is represented by the silvery and liquid metal mercury, also known as quick-silver. Drops of Mercury react on any outside influence (like heat and cold: the...
Earth Mysteries >> Stones, Minerals & Metals
- Aviary at the Gates of Heaven: Examining the Bird Symbolism in the Thoth Empress Card
- "This card, summed up, may be called the Gate of Heaven." Book of Thoth, p. 77. Eight birds adorn the fourth card of the Thoth Deck Major Arcana, The Empress. These eight birds, their variant symbology united, point at one overarching meaning -- as...
Tarot Cards >> The Major Arcana
- Isa
- Last year I wrote the Hagalaz article while snowed in. Later in the year I somehow managed to get the Nauthiz article written. (Library School is going well, got 3 A's and a B, should be finished by the end of 99, and in the spirit of Wunjo, a moderate "h...
Divination >> Rune Stones
Cairns Queensland Transport is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Cairns Queensland Transport books and related discussion.
Suggested Pdf Resources
- Cairns - Transport and Main Roads - Queensland Government
- The CIPTS Study Team acknowledges the financial support provided by Queensland Transport, Department of Main. Roads and the Cairns City Council.
- www.tmr.qld.gov.au
- Queensland Transport and Roads Investment Program
- Road, Gillies Highway and Kennedy Highway (Cairns to. Mareeba).
- www.tmr.qld.gov.au
- Cairns Bus - Transport and Main Roads - Queensland Government
- Cairns Bus Priority Study. Prepared for. Queensland Transport.
- www.tmr.qld.gov.au
- Cairns Integrated Public Transport Study
- www.tmr.qld.gov.au
- ®aQl|Ben5la|1dGovernment
- ®aQl|Ben5la|1dGovernment. _ _. '- Queensland Transport.
- www.sunbus.com.au
Suggested Web Resources
- Cairns Transport - Getting around in Cairns - Cairns - Australia
- Tropical Far North Queensland Cairns Bus Services & Public Transport.
- www.cairnsweb.com.au
- Transport and Main Roads - Queensland Government
- Department of Transport and Main Roads website home page.
- www.tmr.qld.gov.au
- Contact - Transport and Main Roads - Queensland Government
- May 21, 2010 Cairns Qld 4870. Monday–Friday 8.30am – 4.
- www.tmr.qld.gov.au
- Contact us - Transport and Main Roads - Queensland Government
- www.tmr.qld.gov.au
- Queensland Transport, Cairns City QLD 4870 - Freight
- Queensland Transport, Cairns City QLD 4870. Full contact details for Queensland Transport including phone number, map and reviews - TrueLocal.
- www.truelocal.com.au
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
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text:
Dayum son, where'd you find this?
So recently =WMill released some sexy LED Light streaks. Wanted to make something real sexy with em.
Even decided to bring *Vexx3 to collab with me on it too. He helped me a shit ton on the lighting and coloring, as well as coming up with the name and text on this.
Other resolution sizes:
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text:
WASHINGTON -- In closing the deal on health care reform, Democratic leaders assured wavering legislators that the plan would grow more popular with time as its benefits became clear. "We have to pass the bill," argued House Speaker Nancy Pelosi, so that the public "can find out what is in it." Presidential adviser David Axelrod predicted that Republicans would pay a political price for their opposition. "Let's have that fight," he said. "Make my day." Consistent with this belief, the administration recently has been rolling out attractive elements of the law, including coverage for dependents up to age 26.
But after a brief bump, support for Democratic health reform has declined. According to a recent Rasmussen poll, 63 percent of voters support repeal of the law, the highest level since passage. A Kaiser Family Foundation health tracking poll shows erosion in the intensity of support. Last month, 23 percent of Americans held "very favorable" views of the law. This month, that figure is 14 percent, with most of the falloff coming among Democrats (Republicans and independents already being skeptical).
On the theory that the distribution of lollipops usually doesn't provoke riots of resentment, opposition to the health entitlement requires explanation.
One cause is simply economic. At a time when Americans are focused on recovery and job creation -- and how deficits and debt may eventually undermine both -- the economic case for Democratic health reform has been weak, contrived, even deceptive. Recent events in Congress make the point. Two months after passing a law that supporters claimed would reduce federal deficits, largely through Medicare cuts, the House is moving toward a temporary "doctor fix" that would add tens of billions in Medicare costs. Even more expensive fixes are likely in the future. Congressional leaders knew this spending would be necessary when they passed health reform in March. Yet they didn't include this liability in the law, in order to hide the overall cost of the entitlement. In a failing corporation, this would be a scandal, investigated by Congress. In Congress, this is known as legislative strategy.
The economic arguments for reform -- that it would reduce the deficit and health inflation -- were questionable from the beginning. Now they have been revealed as absurd. There is a social justice case for expanding health coverage. But Americans have not found it credible that the creation of a massive new entitlement will somehow help the economy.
Rush Limbaugh defends Rubio's debate answer: He's absolutely right that Obama knows what he's doing | Allahpundit
Time for Team Hillary to break out the gender card for young liberal women who prefer Sanders | Allahpundit


text:
Schools an asset to communityMay 02,2014I am a proud member of the Rutland High School graduating class of 2011. I am currently a student at the University of Vermont, studying mathematics. When I learned that the school budget had been defeated for the first time in history, I was alarmed by the potential damage that could do to the current and future students, the community, and the school system itself. Please support the school budget on May 13.
I attended Rutland City Public Schools from kindergarten through 12th grade. My years within the walls of Rutlands schools and on the athletic fields prepared me well for my studies at UVM and my career beyond. The school system in Rutland is an asset to the entire community and one of the reasons people do decide to move to the area.
Please support the school budget on May 13.
RutlandMORE IN LettersGrowing up in rural Michigan, the closest dentist was a 40-minute drive from our house. Full StoryThe article in the Feb. 4 Herald about forum conflicts has some errors which require correction. Full StoryMy thanks to the Rutland Herald for covering my candidacy for the Rutland Town Select Board. Full Story
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Please explain how :D
Is Energy mean momentum in your question? I'm no pro, but still trying my best to answer your question.;p
Does light count? electromagnetic wave? isn't that depending on the definition of energy?
Since a universe without matter would be observer-free, no measurements could be made so this is clearly not science.
Separate names with a comma.


text:
Vincent Yu
Apparently, this user prefers to keep an air of mystery about them.
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Member Since: May 2, 2010
Country: United States
should I still be expecting an email, or will the prizes just show up at my door?
I have no idea what to do with the freesoc2. any ideas?
this is the best day of my life
2nd Amendment: the right to bare armatures
I see you, Firefly
you could potentially reflow the devices and try to get the solder balls to re-wet, but since they use lead-free solder, it's unlikely that they will form one ball. At manufacturing, oxide layers can build up on the solder balls. Out solution was to change the heating profile and use Nitrogen in the oven to reduce oxidation. or something like that - I'm not a chemist.
The difficulty with such a manufacturing failure is you don't exhaust resources to try and design fail-safes for unforeseen failure modes, you do the best you can at low volumes to make your yield as high as possible. Head-in-pillow is an incredibly difficult problem to find, and an incredibly difficult problem to completely fix. The best we can do is AT LEAST run a system check to make sure all your peripherals respond, and if something doesn't, throw an error or blink an LED code. It's much more helpful than just having the thing not turn on at all.
I have a bit of insight on the RROD xbox failures. It was most likely due to poor solder quality on the BGA device, a phenomenon known as head-in-pillow, where the solder balls do not wet properly into the pads and you get two separate snowman-like solder balls that are electrically connected until heated or shocked where they break apart and will intermittently fail. Credibility: I'm a test engineer, and I had to deal with this manufacturing defect in a product last year.
probably not. there are a lot of similar concepts I'm stealing from that site, and video games like Halo, but hardware-wise I'm hoping to just develop one board + screen that you can solder into a stock LTTO gun, then download an arduino sketch and that's it.
I'm working on a laser tag hack, using Hasbro's Lazer Tag Team Ops guns. I bought a bunch on ebay for cheap and have started capturing and deciphering the codes. In parallel, I'm developing my own main board and screen to replace the gun's main board and screen so that I can write my own game rules. It will be based on the Teensy 3.1.
No public wish lists :(


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Located in San Francisco (South of Market), Good Hotel is minutes from San Francisco Federal Building and International Art Museum of America. This hotel is close to Union Square and Lombard Street.
Make yourself at home in one of the 117 guestrooms featuring iPod docking stations and flat-screen televisions. Complimentary wireless Internet access keeps you connected, and cable programming is available for your entertainment. Private bathrooms with bathtubs or showers feature complimentary toiletries and hair dryers. Conveniences include coffee/tea makers and ceiling fans, and housekeeping is provided daily.
Rec, Spa, Premium Amenities
Take advantage of recreation opportunities such as a fitness center, or other amenities including complimentary wireless Internet access and concierge services.
Business, Other Amenities
Featured amenities include complimentary newspapers in the lobby, dry cleaning/laundry services, and a 24-hour front desk. Guests may use a roundtrip airport shuttle for a surcharge, and self parking (subject to charges) is available onsite.
The location isn't terrible and the hotel is pretty cute. I think they must have raided an Ikea for the room decor. The parking lot isn't that big, and we had to pay $40 to valet at another hotel across the street. When we got to our room, we noticed it smelled funny and the carpet was wet under the window near the radiator. They moved us to another room which I think was a little smaller. The bathroom was unbelievably small, even for an older hotel. A larger person would have had quite a bit of difficulty getting ready in the mirror or using the toilet. Being that it was NYE, it was very loud. There were parties going on in other rooms and we could hear everything from loud music to couples having mediocre sex.
Be careful walking around at night, lots of homeless, not a great area. The idea the hotel is trying for is good. I like the bulk shampoo & soap dispensers.
The bed was small and uncomfortable, on a wooden crate of all things. We asked for pillows three times after waiting patiently between each request and housekeeping never brought them. The front desk was apathetic. Parking ends up being almost $40 in addition to the already way overpriced hotel room.
I really enjoyed the fact that it was close to most of the main attractions in San Francisco. My boyfriend and I could walk to most places from the hotel.
I really didn't dislike much about the hotel. I think it would be cool if they offered complimentary breakfast :-) San Fran can be pretty expensive so having something taken care for us would be nice
The room was clean and the location is right downtown which is perfect. Probably only good for a short stay
There were only two pillows, the room was hot, and the tv was small. We weren't there to watch tv, but the last hotel we stayed at in Santa Cruz had a decent sized one so we were probably spoiled by that experience. This place is good if you need a place to crash, but something about it was just ehh. And you might as well pay the $30 to park in their lot because you'll never find parking in SF. And all the street parking surrounding it was only 1hr parking until 10pm
Decently priced compared to other hotels in San Francisco. The rooms were updated and nice. Good use of environmentally friendly amenities. No AC and the room we had got pretty warm when the sun came up, but the windows open so we could still cool off the room. Staff was very friendly and helpful. Free bikes for guests to use. Close to touristy areas and public transit.
Lobby and hallways were a bit dated. Location was a bit sketchy at night, but we never felt unsafe. Housekeeping was sporadic. During our 4 night stay our room was not made up on 1 day and when we checked in around midnight, they had to check to make sure our room had been cleaned. Can be noisy at night with outside noise.
For all the eco-friendly/green, modern people out there this may be one of your best options in the city. They do their best to be eco-friendly and I'm sure they'll keep making improvements. They also have free bike rentals which was nice! The staff was quick to help, it was a great deal for our money, the "double bed" room was small but that doesn't bother me, get a queen room if you need the space. Other than that I'm sure you'll like it.
Parking was a bit expensive but there are no decent hotels with free parking.
The hotel has everything you need for a business trip. It's clean and affordable. There are restaurants near the hotel and a CVS, where you can get whatever you need.
Some of the staff members at the front desk weren't the nicest.
The location was good, and staff was friendly. I liked my room and checked out a couple of the free bikes to ride to Golden Gate Park. Had an issue with the toilet when I arrived which was dealt with immediately when I called the front desk.
No refrigerator, room was a little small.
Friendly front staff. Easy check-in.
Bed was terribly uncomfortable. One of the worst I've ever slept on, and I'm pretty easy to please. The hotel was billed as eco-friendly which must be code for cheap, sterile, minimalist decor. A no frills room and I spent a LOT of money to stay here. I recommend staying at the Americania across the street. Same company, but an entirely different hotel experience.
I was very happy with my stay. The Good Hotel met all my expectations. At the price it is the best hotel in SF.


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Investing & Saving for Grandchildren
A new grandbaby in the family can provide all sorts of excitement and
gift-giving opportunities. Beyond the cute clothes, toys and functional necessities, one of the most lasting and important gifts you can give is the foundation for a solid financial future for your new family member.
- Investments for
- Giving your grandchild
a financial head-start
- Providing for your
special needs grandchild
Investments for Grandchildren
An education fund can have a lasting impact on the lives of your grandchildren, because it can help them find and establish themselves in a profession they love. Talk to your Financial Advisor today and learn how you can help make investments for your grandchildren.
Establishing a 529 plan. 529 plans are designed specifically to help people establish college savings for children. The benefits of 529 plans include tax-deferred accumulation and federally tax-exempt withdrawals when the money is used for qualified college education expenses. In addition, gifts to a 529 plan remove those assets from your taxable estate.
The availability of such tax or other benefits may be conditioned on meeting certain requirements.
Please note: All gifts are subject to the annual gift tax exclusion amount, which is $13,000 for 2012 -- including those to trusts, custodial accounts, 529 plans, etc. Contact your tax advisor for more specific information.
- Pay your grandchild's tuition directly. You also can pay your grandchild's education expenses directly to a primary, secondary or post-secondary educational institution. Payments made directly to the institution are not considered gifts for gift tax purposes; therefore, they do not use up your annual gift tax exclusion amount. And of course, those funds are removed from your taxable estate.
No other gifts may be made to the beneficiary for a five-year period. A portion of the contribution may be subject to recapture if the donor dies within those five years.
Please consider the investment objectives, risk, charges and expenses carefully before investing in a 529 savings plan. The official statement, which contains this and other information, can be obtained by calling your financial advisor. Read it carefully before you invest.
Learn more about education funding.
Giving Your Grandchild a Financial Head-Start
There are many ways you can lay the foundation for your grandchild's future, some of which may also benefit your estate if estate taxes are a concern.
- Establishing a trust. Setting aside money in a trust for your grandchild can let you set the standards for how that money is used, whether by the trustee, the parents or the child when he or she is eligible for distributions. An irrevocable trust removes the amount you put in the trust from your estate.
- Gifting investments. By setting up a custodial account, your grandchild can have an established investment portfolio when he or she becomes an adult. This can also give you an opportunity to teach your grandchild about investing as the two of you track the movements of the portfolio. Keep in mind that gifts to a custodial account are irrevocable. The custodian controls the assets and makes decisions about distributions.
Learn more about estate planning and trusts.
Note: Trust services available through banking and trust affiliates in addition to non-affiliated companies of Wells Fargo Advisors. Wells Fargo Advisors and its affiliates do not provide legal or tax advice. Any estate plan should be reviewed by an attorney who specializes in estate planning and is licensed to practice law in your state.
Providing for Your Special Needs GrandchildIf a grandchild is disabled or has special needs that are accompanied by extraordinary expenses, providing for them can be very complex. Every situation is different so it's important to work with your family attorney and other professionals to create an appropriate plan.
Government benefits and programs. In some cases, the family may decide that it's critical to maintain a child's eligibility for government benefits and programs. In those cases, it may be appropriate to avoid certain types of gifts that could cause a child to lose eligibility. There are a variety of federal and state assistance programs, and each one has differing eligibility criteria.
Special needs trust. A "special needs trust" allows family members to provide financially for a special needs child without harming his or her eligibility for those government benefits and programs. At the same time, a special needs trust may be subject to restrictions on how (or how much) money is used, so it does not fit in every case. In some situations, a grandchild may need help with a disability but can live a full and independent life without any need for governmental assistance; if so, a more flexible trust can be used or you may even be able to provide direct financial assistance.
In developing a plan, it's a good idea to seek advice from a variety of knowledgeable specialists. This group could include an attorney, physicians, social workers and counselors, and nonprofit organizations who have experience in dealing with a particular type of disability or medical condition.
A financial advisor can work closely with you, your attorney and other professional advisors to help you implement strategies for providing for a special needs child.
Note: Trust services available through banking and trust affiliates in addition to non-affiliated companies of Wells Fargo Advisors. Wells Fargo Advisors and its affiliates do not provide legal or tax advice. Any estate plan should be reviewed by an attorney who specializes in estate planning and is licensed to practice law in your state.
We're With You Every Step of the WayYour situation changes over time. So do your needs and goals. That's why our financial advisors will be there to provide you ongoing guidance -- along with the exceptional service you deserve. That's what it means to be with Wells Fargo Advisors.
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We track four people on their journey.
Zika virus: 'We have more questions than answers'
29 Nov 2011 10:03 GMT | Politics, US & Canada, Iraq, United States
Robert Jensen is a professor at the School of Journalism at the University of Texas, Austin.
Conventional politics in the United States focuses on elections, while leftist activists typically argue that political change comes not from electing better politicians but building movements strong enough to force politicians to accept progressive change. Norman Solomon has concluded it isn't an either/or choice. A prominent writer and leader in leftist movements for decades, Solomon is running for Congress in the hopes of being practical and remaining principled. "Since I first went to a protest at age 14 in 1966 - a picket line to desegregate an apartment complex - my outlook on electoral politics has gone through a lot of changes," Solomon said. "First I thought politics was largely about elections, later I thought politics had very little to do with elections, and now
Conventional politics in the United States focuses on elections, while leftist activists typically argue that political change comes not from electing better politicians but building movements strong enough to force politicians to accept progressive change. Norman Solomon has concluded it isn't an either/or choice. A prominent writer and leader in leftist movements for decades, Solomon is running for Congress in the hopes of being practical and remaining principled. "Since I first went to a protest at age 14 in 1966 - a picket line to desegregate an apartment complex - my outlook on electoral politics has gone through a lot of changes," Solomon said. "First I thought politics was largely about elections, later I thought politics had very little to do with elections, and now I believe that elections are an important part of the mix."
Live Box 201111485425466767
Solomon argues that when the left has treated elections as irrelevant, the result has been self-marginalisation that helps empower the military-industrial complex. "The view that genuine progressives should leave the electoral field to corporate Democrats and right-wing Republicans no longer makes sense to me. I used to say that having a strong progressive movement was much more important than who was in office, but now I'd say that what we really need is a strong progressive movement and much better people in office," he said. "Having John Conyers, Barbara Lee, Dennis Kucinich, Jim McGovern, Raul Grijalva, Lynn Woolsey in Congress is important. We need more of those sorts of legislators as part of the political landscape."The 60-year-old Solomon had been considering such a strategy, and when Woolsey announced she was not running for re-election in her northern California district, he entered the race with the goal of staying true to his left-leaning political views, and winning.
A progressive movement"I'm sceptical about election campaigns that abandon principles, but I'm also sceptical about campaigns that have no hope of winning and that are only for protest or public education," he said. "There are more effective ways to protest and to educate."Solomon said that, if elected, he would strive to change the relationship between social movements and members of Congress. "Progressive movements and leaders in Congress should be working in tandem," he said. "I want to strengthen the Congressional Progressive Caucus and help make it more of a force to be reckoned with."
The call for planetary patriotism Occupy demands: Let's radicalise our analysis
Solomon said that a re-invigorated Progressive Caucus could be more effective in fighting for the human right of quality healthcare for all; ending the perpetual war of the warfare state, what Martin Luther King Jr called "the madness of militarism"; pushing back against the power of Wall Street; replacing corporate power with people power.Solomon is most widely known for his media criticism and activism, through his Media Beat weekly column that was nationally syndicated and his work with Fairness & Accuracy in Reporting. In 1997, he founded the Institute for Public Accuracy, a national consortium of policy researchers and analysts for which he served as executive director for 13 years.Solomon became more visible in mainstream media through his trip to Iraq with actor Sean Penn on the eve of the US invasion, part of anti-war efforts to prevent that coming catastrophe. Solomon's 2005 book, War Made Easy: How Presidents and Pundits Keep Spinning Us to Death, and a companion film drew on his media and political expertise to analyse the war machine. (Full disclosure: I found the book and film so compelling that I brought Solomon to my campus to speak.)Polls indicate that Solomon is competitive in a Democratic primary that includes a state assemblyman, a county supervisor, and two business people. Penn is supporting Solomon's campaign, which has also received endorsement from US Representative Raul Grijalva, co-chair of the Congressional Progressive Caucus, and Dolores Huerta, co-founder of the United Farm Workers. Fundraising is always a struggle, especially since he committed to "corporate-free fundraising".
No corporate sponsors"By raising more than $250,000 from more than 2,000 different people, we've shown that we can raise the needed funds without a single dollar from corporate PACs," Solomon said. "But we need to raise a lot more, and the month of December will be crucial - end-of-year totals will be seen by many as a self-fulfilling gauge of our capacity to gain enough support to win."Solomon believes that citizen frustration with concentrated wealth, and the political dominance that big money buys, is opening up new possibilities for progressive candidates.
Live Box 201110415333680466
"Our campaign is very much in sync with Occupy Wall Street," he said. "Issues that I've been talking about from the outset of this campaign last January, and for many years before that, are part of the OWS focus - Wall Street's undemocratic power, the widening disparities between the rich and the rest of us, the need to eject corporate money from politics."Solomon has described his politics as "green New Deal", arguing for a vigorous government role in providing quality education, adequate health care, consumer protection, civil liberties and environmental safeguards. For leftists, two questions hover: Can a candidate go beyond liberal positions and articulate anti-capitalist and anti-empire politics during a campaign? If elected, can a member of Congress stay true to those principles? Movement activists are wary of left/liberal politicians who push their rhetoric toward the centre to get elected and then end up advocating centrist policies. Solomon said he identifies with a phrase Penn used at a campaign rally: "Principle as strategy.""I intend to stick with principles, what I believe and what I'm willing to fight for," Solomon said. "The quest is not for heightened rhetoric, it's for deeper meaning, with insistence on policies to match - economic populism, human rights, civil liberties, ending wars and working for social equity."Though that agenda suggests radical change, Solomon said he doesn't use the term "radical", opting instead for terms such as "genuine progressive", "progressive populism" and "independent progressive" to describe himself and his campaign. "The term radical can be understood as 'to the root', but what it conveys to most of the public is that we are extreme and the status quo isn't," he said. "But look at the huge disparities between rich and poor, catastrophic climate change and destruction of ecology, inflicting massive suffering, extreme violence of war and on and on. I would say the status quo is extreme."
Robert Jensen is a professor at the School of Journalism at the University of Texas, Austin. His latest book is titled All My Bones Shake: Seeking a Progressive Path to the Prophetic Voice.The views expressed in this article are the author's own and do not necessarily represent Al Jazeera's editorial policy.
Source: Al Jazeera
The eviction deadline for Occupy LA protestors is nearing, but demonstrators are vowing to stand their ground.
Arts & Culture
The Occupy movement has taken the development of civil society into a previously unimaginable direction.
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Poverty & Development, Asia, India
Cubans get amnesty at the US border, but reaching it involves a risky journey along the Central American migrant trail.
Human Rights, Latin America, Cuba
In many ways, Michael is just like any other 11-year-old, but he has had four open heart surgeries.
Health, US & Canada
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Arts & Culture, Latin America, Peru
Activist Maryam al-Khawaja in debate with Mansoor al-Arayedh, the chairman of the Gulf Council for Foreign Relations.
Human Rights, Bahrain, Arab Spring
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Health, Latin America, Brazil
Hundreds of Cambodian journalists make a living by uncovering news and then extorting bribes to bury the story.
Media, Journalism, Cambodia
How will improving relations between communist Cuba and the capitalist US affect the lives of people on both sides?
Politics, United States, Cuba


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Best Free Concert (2010)
Twist & Shout
Couldn't get tickets to see Matt Morris at the Bluebird? Couldn't find a babysitter in time to make it to the Flobots show at the Ogden? Not to worry: Twist & Shout has you covered with a full calendar of in-store performances featuring the most laudable locals — everyone from Rose Hill Drive to DeVotchKa to Paper Bird. And they sometimes bring in acts from outside the area code. On Record Store Day this month, for example, Paul Epstein's legendary shop will host a special DJ set by Bonobo. Past performances have included Jason Isbell and the 400 Unit, Ben Harper & the Innocent Criminals, and Jon Butler — all of whom have recorded and released the in-store gigs. And the best part? Every performance is free. Now, that's something to shout about.
More Arts & Entertainment Awards
Best Venue for Dance/Avant-GardePacking House Center for the Arts
Best Boulder Theater Booster, RIPFrank Georgianna
Best Unsung Arts SeriesNewman Center for the Performing Arts
Best Theater Booster, RIPJeffrey Nickelson


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some more fotos to C/C
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Andrew Niccol
Birth Name: Andrew Niccol
Born: 01/01/1964
Birth Place: New Zealand
New Zealand-born screenwriter-director Andrew Niccol began his career in London, successfully directing TV commercials before moving to Los Angeles in order to make films "longer than 60 seconds." He interested high-powered producer Scott Rudin in his "The Truman Show" (1998) script, but Rudin was not willing to gamble on a rookie director, particularly when Jim Carrey came aboard, swelling the budget to about $60 million. Peter Weir helmed instead, bringing a complementary vision which lightened the material somewhat, and the clever satire, which followed a cheerful insurance man (Carrey) as he slowly realizes that all the people in his life are just actors in a TV show, opened to critical ...
Check Out 'In Time' On Blu-ray & DVD Jan. 31
Two Jews' Review 'In Time' - Both Agree This Sci-Fi Thriller Is A Waste Of Time (Video)
Two Jews' Review 'In Time' - Both Agree This Sci-Fi Thriller Is A Waste Of Time (Video)
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