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AMD Unveils New Gamer Memory: MOAR RAMDISK!
Subject: Memory | May 8, 2013 - 12:01 AM | Josh Walrath
Tagged: radeon ramdisk, radeon, memory, amd, 4GB, 2133, 1.65v
AMD makes memory! Ok, they likely contract out memory. Then they brand it! Then they throw in some software to make RAMDisks out of all that memory that you are not using. Let us face it; AMD is not particularly doing anything new here with memory. It is very much a commodity market that is completely saturated with quality parts from multiple manufacturers.
So why is AMD doing it? Well, I guess part of it is simply brand recognition and potentially another source of income to help pad the bottom line. They will not sell these parts for a loss, and they will have buyers with the diehard AMD fans. Tim covered the previous release of AMD memory pretty well, and he looked at the performance results of the free RAMDisk software that AMD bundled with the DIMMs. It does exactly what it is supposed to, but of course it takes portions of memory away. When dealing with upwards of 16 GB of memory for a desktop computer, sacrificing half of that is really not that big a deal unless heavy duty image and video editing are required.
*Tombraider not included with Radeon Memory. Radeon RAMDisk instead!
Today AMD is announcing a new memory product and a new bundled version of the RAMDisk software. The top end SKU is now the AMD Radeon RG2133 DDR-3 modules. It comes in a package of up to 4 x 4GB DIMMS and carries a CAS latency of 10 with the voltage at a reasonable 1.65v. These modules are programmed with both the Intel based XMP and the AMD based AMP (MP stands for Memory Profiles… if that wasn't entirely obvious). The modules themselves are reasonable in terms of size (they will fit in any board, even with larger heatsinks on the CPU). AMD claims that they are all high quality parts, which again is not entirely surprising since I do not know of anyone who advertises that their DIMMS feature only the most mediocre memory modules available.
Faster memory is faster, water is wet, and Ken still needs a girlfriend.
AMD goes on to claim that faster memory does improve overall system performance. Furthermore AMD has revealed that UV light is in fact a cancer causing agent, Cocoa Puffs will turn any milk brown, and passing gas in church will rarely be commented upon (unless it is truly rank or you start calling yourself "Legion"). Many graphs were presented that essentially showed an overclocked APU with this memory will outperform a non-overclocked APU with DDR-3 1600 units. Truly eye opening, to say the least.
How much RAMDisk can any one man take? AMD wants to know!
The one big piece of the pie that we have yet to talk about is the enhanced version of Radeon RAMDisk (is Farva naming these things?). This particular version can carve out up to 64 GB of memory for a RAMDisk! I can tell you this now, me and my 8 GB of installed memory will get a LOT of mileage out of this one! I can only imagine the product meeting. "Hey, I've got a great idea! We can give them up to 64 GB of RAMDisk!" While another person replies, "How do you propose getting people above 64 GB, much less 32 GB of memory on a consumer level product…?" After much hand wringing and mumbling someone comes up with, "I know! They can span it across two motherboards! That way they have to buy an extra motherboard AND a CPU! Think of our attach rate!" And there was much rejoicing.
So yes, more memory that goes faster is better. Radeon RAMDisk is not just a comic superhero, it can improve overall system performance. Combine the two and we have AMD Radeon Memory RG2133 with 64 GB of RAMDisk. Considering that the top SKU will feature 4 x 4GB DIMMS, a user only needs to buy four kits and four motherboards and processors to get a 64GB RAMDisk. Better throw in another CPU and motherboard so a user can at least have 16GB of memory available as, you know, memory.
Update and Clarification
Perhaps my tone was a bit too sarcastic, but I just am not seeing the value here. Apparently (and I was not given this info before hand) the 4 x 4 GB kits with the 64 GB RAMDisk will retail at $155. Taking a quick look at Newegg I see that a user can buy quite a few different 2 x 8 GB 2133 kits anywhere from $139 to $145 with similar or better latencies/voltages. Around $155 users will get better latencies and voltages down to 1.5v. For 4 x 4GB kits we again see prices start at the $139 mark, but there are a significant number of other kits with again better voltages and latencies from $144 through $155.
Users can also get the free version of the Radeon RAMDisk that will utilize up to 4GB of space. There are multiple other software kits for not a whole lot of money (less than $10) that will provide you up to 16 GB of RAMDisk. I just find the whole kit to be comparable to what is currently out there. Offering a 64 GB RAMDisk for use with 16 GB of total system memory just seems to be really silly. The only way that could possibly be interesting would be if you could allocate 8 GB of that onto RAM and the other 56 GB onto a fast SSD. I do not believe that to be the case with this software, but I would love to be proved wrong.
Podcast #249 - Corsair 350D, Frame Rating in 4K, the Oculus Rift and more!
Subject: General Tech | May 2, 2013 - 02:59 PM | Ken Addison
Tagged: podcast, video, Indiegogo, corair, obsidian, 350d, mATX, frame rating, 4k, titan, 7990, 690, Oculus, rift, VR, 3d, amd, amd fx, vishera, hUMA, hsa
PC Perspective Podcast #249 - 05/02/2013
Join us this week as we discuss the Corsair 350D, Frame Rating in 4K, the Oculus Rift and more!
You can subscribe to us through iTunes and you can still access it directly through the RSS page HERE.
The URL for the podcast is: http://pcper.com/podcast - Share with your friends!
- iTunes - Subscribe to the podcast directly through the iTunes Store
- RSS - Subscribe through your regular RSS reader
- MP3 - Direct download link to the MP3 file
Hosts: Josh Walrath, Allyn Malventano, Scott Michaud and Morry Teitelman
Program length: 1:04:02
Week in Review:
0:05:00 Corsair Obsidian 350D Case
0:10:30 AMD Details hUMA for HSA
News items of interest:
0:38:30 Oculus Rift hands on testing
0:44:00 AMD Refreshes FX CPUs
Ryan: Windows Movie Maker lets you record webcam videos!
Jeremy: anti-pick - hotels that don't offer a RJ45 jack in the rooms!
Allyn: Ventev USB charging stuff (home / auto)
Morry: Far Cry 3 Blood Dragon
1-888-38-PCPER or email@example.com
AMD Planning APU13 Developer Summit In San Jose, California
Subject: General Tech | May 1, 2013 - 07:08 AM | Tim Verry
Tagged: hUMA, hsa, apu13, APU, amd, AFDS
AMD announced its third annual Developer Summit last week. Dubbed "APU13," the upcoming summit is the AMD equivalent to NVIDIA's GTC and is an annual event that brings together industry analysts, researchers, programmers, academics, and software/hardware companies pursuing heterogeneous computing technologies.
In previous years, the AMD Developer Summit has been the launchpad for C++ AMP and the HSA Foundation. This year's Summit will continue that trend towards heterogeneous computing as well as look back over the year and provide updates on where the various HSA member companies are at as far as goals to move towards standards-based heterogenous computing.
In addition to keynote speeches from AMD and some of its partners, expect a great deal of presentations and workshops from researchers and programmers that are working on new programming models and hardware solutions to efficiently use CPU and GPU processors. More information on hUMA is one of the likely topics, for example. Discussion about upcoming hardware, process nodes, and products may also be on the table so far as it relates to the HSA theme. Considering the summit is called "APU13," I also expect that AMD will reveal additional details on the company's Kaveri APU as well as a look into its future product road map.
AMD is currently asking for presentation proposals from researchers in a number of HSA and technology-related fields including heterogeneous computing, cloud computing, web technologies, programming languages, gaming and graphics technologies, and software security. The lineup of presenters for the summit is still being worked out, and proposal papers will be accepted until May 10th with the winners being notified over the summer.
In all, AMD's APU13 should be an exciting and intellectual event. Last year's AMD Fusion Developer Summit (AFDS) was an interesting and fun event to cover, and I hope that APU13 will keep up the same momentum and interest in heterogeneous computing that AFDS started.
Our 4K Testing Methods
You may have recently seen a story and video on PC Perspective about a new TV that made its way into the office. Of particular interest is the fact that the SEIKI SE50UY04 50-in TV is a 4K television; it has a native resolution of 3840x2160. For those that are unfamiliar with the new upcoming TV and display standards, 3840x2160 is exactly four times the resolution of current 1080p TVs and displays. Oh, and this TV only cost us $1300.
In that short preview we validated that both NVIDIA and AMD current generation graphics cards support output to this TV at 3840x2160 using an HDMI cable. You might be surprised to find that HDMI 1.4 can support 4K resolutions, but it can do so only at 30 Hz (60 Hz 4K TVs won't be available until 2014 most likely), half the refresh rate of most TVs and monitors at 60 Hz. That doesn't mean we are limited to 30 FPS of performance though, far from it. As you'll see in our testing on the coming pages we were able to push out much higher frame rates using some very high end graphics solutions.
I should point out that I am not a TV reviewer and I don't claim to be one, so I'll leave the technical merits of the monitor itself to others. Instead I will only report on my experiences with it while using Windows and playing games - it's pretty freaking awesome. The only downside I have found in my time with the TV as a gaming monitor thus far is with the 30 Hz refresh rate and Vsync disabled situations. Because you are seeing fewer screen refreshes over the same amount of time than you would with a 60 Hz panel, all else being equal, you are getting twice as many "frames" of the game being pushed to the monitor each refresh cycle. This means that the horizontal tearing associated with Vsync will likely be more apparent than it would otherwise.
I would likely recommend enabling Vsync for a tear-free experience on this TV once you are happy with performance levels, but obviously for our testing we wanted to keep it off to gauge performance of these graphics cards.
Continue reading our results from testing 4K 3840x2160 gaming on high end graphics cards!!
AMD Releases FX CPU Refreshes
Subject: Processors | April 30, 2013 - 02:04 PM | Josh Walrath
Tagged: amd, FX, vishera, bulldozer, FX-6350, FX-4350, FX-6300, FX-4300, 32 nm, SOI, Beloved
Today AMD has released two new processors that address the AM3+ market. The FX-6350 and FX-4350 are two new refreshes of the quad and hex core lineup of processors. Currently the FX-8350 is still the fastest of the breed, and there is no update for that particular number yet. This is not necessarily a bad thing, but there are those of us who are still awaiting the arrival of the rumored "Centurion".
These parts are 125 watt TDP units, which are up from their 95 watt predecessors. The FX-6350 runs at 3.9 GHz with a 4.2 GHz boost clock. This is up 300 MHz stock and 100 MHz boost from the previous 95 watt FX-6300. The FX-4350 runs at 3.9 GHz with a 4.3 GHz boost clock. This is 100 MHz stock and 300 MHz boost above that of the FX-4300. What is of greater interest here is that the L3 cache goes from 4 MB on the 4300 to 8 MB on the 4350. This little fact looks to be the reason why the FX-4350 is now a 125 watt TDP part.
It has been some two years since AMD started shipping 32 nm PD-SOI/HKMG products to the market, and it certainly seems as though spinning off GLOBALFOUNDRIES has essentially stopped the push to implement new features into a process node throughout the years. As many may remember, AMD was somewhat famous for injecting new process technology into current nodes to improve performance, yields, and power characteristics in "baby steps" type fashion instead of leaving the node as is and making a huge jump with the next node. Vishera has been out for some 7 months now and we have not really seen any major improvement in regards to performance and power characteristics. I am sure that yields and bins have improved, but the bottom line is that this is only a minor refresh and AMD raised TDPs to 125 watts for these particular parts.
The FX-6350 is again a three module part containing six cores. Each module features 2 MB of L2 cache for a total of 6 MB L2 and the entire chip features 8 MB of L3 cache. The FX-4350 is a two module chip with four cores. The modules again feature the same 2 MB of L2 cache for a total of 4 MB active on the chip with the above mentioned 8 MB of L3 cache that is double what the FX-4300 featured.
Perhaps soon we will see updates on FM2 with the Richland series of desktop processors, but for now this refresh is all AMD has at the moment. These are nice upgrades to the line. The FX-6350 does cost the same as the FX-6300, but the thinking behind that is that the 6300 is more "energy efficient". We have seen in the past that AMD (and Intel for that matter) does put a premium on lower wattage parts in a lineup. The FX-4350 is $10 more expensive than the 4300. It looks as though the FX-6350 is in stock at multiple outlets but the 4350 has yet to show up.
These will fit in any modern AM3+ motherboard with the latest BIOS installed. While not an incredibly exciting release from AMD, it at least shows that they continue to address their primary markets. AMD is in a very interesting place, and it looks like Rory Read is busy getting the house in order. Now we just have to see if they can curve back their cost structure enough to make the company more financially stable. Indications are good so far, but AMD has a long ways to go. But hey, at least according to AMD the FX series is beloved!
hUMA has come with a weapon to slay the memory latency dragon
Subject: General Tech | April 30, 2013 - 01:23 PM | Jeremy Hellstrom
Tagged: Steamroller, piledriver, Kaveri, Kabini, hUMA, hsa, GCN, bulldozer, APU, amd
AMD may have united GPU and CPU into the APU but one hurdle had remained until now, the the non-uniformity of memory access between the two processors. Today we learned about one of the first successful HAS projects called Heterogeneous Uniform Memory Access, aka hUMA, which will appear in the upcoming Kaveri chip family. The use of this new technology will allow the on-die CPU and GPU to access the same memory pool, both physical and virtual and any data passed between the two processors will remain coherent. As The Tech Report mentions in their overview hUMA will not provide as much of a benefit to discrete GPUs, while they will be able to share address space the widely differing clock speeds between GDDR5 and DDR3 prevent unification to the level of an APU.
Make sure to read Josh's take as well so you can keep up with him on the Podcast.
"At the Fusion Developer Summit last June, AMD CTO Mark Papermaster teased Kaveri, AMD's next-generation APU due later this year. Among other things, Papermaster revealed that Kaveri will be based on the Steamroller architecture and that it will be the first AMD APU with fully shared memory.
Last week, AMD shed some more light on Kaveri's uniform memory architecture, which now has a snazzy marketing name: heterogeneous uniform memory access, or hUMA for short."
Here is some more Tech News from around the web:
- AMD's new heterogeneous Uniform Memory Access
- hUMA; AMD's Heterogeneous Unified Memory Architecture @ Hardware Canucks
- Compro TN50W Cloud Network Camera @ Tweaktown
- Wifi Pineapple project uses updated hardware for man-in-the-middle attacks @ Hack a Day
- New OpenWRT Drops Support For Linux 2.4, Low-Mem Devices @ Slashdot
- HP mashes up ProLiant, Integrity, BladeSystem, and Moonshot server @ The Register
- Acer selling tablet using Intel Y series processor @ The Register
- CERN Celebrates 20 Years of an Open Web (and Rebuilds 1st Web Page) @ Slashdot
- BitFenix 5K YouTube Subscriber Giveaway @ eTeknix
heterogeneous Uniform Memory Access
Several years back we first heard AMD's plans on creating a uniform memory architecture which will allow the CPU to share address spaces with the GPU. The promise here is to create a very efficient architecture that will provide excellent performance in a mixed environment of serial and parallel programming loads. When GPU computing came on the scene it was full of great promise. The idea of a heavily parallel processing unit that will accelerate both integer and floating point workloads could be a potential gold mine in wide variety of applications. Alas, the promise of the technology did not meet expectations when we have viewed the results so far. There are many problems with combining serial and parallel workloads between CPUs and GPUs, and a lot of this has to do with very basic programming and the communication of data between two separate memory pools.
CPUs and GPUs do not share common memory pools. Instead of using pointers in programming to tell each individual unit where data is stored in memory, the current implementation of GPU computing requires the CPU to write the contents of that address to the standalone memory pool of the GPU. This is time consuming and wastes cycles. It also increases programming complexity to be able to adjust to such situations. Typically only very advanced programmers with a lot of expertise in this subject could program effective operations to take these limitations into consideration. The lack of unified memory between CPU and GPU has hindered the adoption of the technology for a lot of applications which could potentially use the massively parallel processing capabilities of a GPU.
The idea for GPU compute has been around for a long time (comparatively). I still remember getting very excited about the idea of using a high end video card along with a card like the old GeForce 6600 GT to be a coprocessor which would handle heavy math operations and PhysX. That particular plan never quite came to fruition, but the idea was planted years before the actual introduction of modern DX9/10/11 hardware. It seems as if this step with hUMA could actually provide a great amount of impetus to implement a wide range of applications which can actively utilize the GPU portion of an APU.
Click here to continue reading about AMD's hUMA architecture.
MSI's FM2-A85XA-G65, an inexpensive start to a great HTPC
Subject: Motherboards | April 26, 2013 - 03:32 PM | Jeremy Hellstrom
Tagged: msi, FM2-A85XA-G65, socket fm2, amd
Compared to most current Intel boards, MSI's FM2-A85XA-G65 is very clean looking, especially around the CPU socket. This particular board benefits from LucidLogix's Virtu MVP in addition to hybrid Crossfire present on FM2 boards and will handle proper Crossfire as it does have a pair of PCIe 16x slots. You could build an agile HTPC with this motherboard, with 8 channel sound available and D-Sub, DVI-D, HDMI and DisplayPort output all present. The board is currently available for $110, a full review can be found over at X-bit Labs.
"MSI mainboards look great, have very convenient layout and use only high-quality components. These boards are energy-efficient, fast and work well with default settings. However, there are quite a few things in their BIOS that could use some extra work and the boards do not keep the power-saving technologies up and running during overclocking. Everything we have just said is true for the main hero of our today's review."
Here are some more Motherboard articles from around the web:
- ASRock FM2A85X Extreme6 Socket FM2 @ X-bit Labs
- Asus F2A85-V PRO @ X-bit Labs
- BIOS Option Of The Week - OS Select For DRAM > 64MB @ TechARP
- MSI Z77A-GD65 GAMING Intel LGA 1155 @ techPowerUp
- Asus P8Z77-V LK @ eTeknix
- MSI Z77A-GD65 @ eTeknix
- Asus P8Z77-V @ eTeknix
- MSI Z77A-GD65 @ Kitguru
- Gigabyte GA-Z77X-UD5H-WB Intel Z77 Motherboard Review @ PCSTAT
- ASRock Fatal1ty X79 Champion @ eTeknix
Podcast #248 - AMD HD 7990, CrossFire Frame Rating improvements, 4K TVs and more!
Subject: General Tech | April 25, 2013 - 02:13 PM | Ken Addison
Tagged: video, Xe, seiki, raidr, podcast, nvidia, Never Serttle, hd 7990, GA-Z77N-WiFi, frame rating, crossfire, amd, 4k
PC Perspective Podcast #248 - 04/25/2013
Join us this week as we discuss AMD HD 7990, CrossFire Frame Rating improvements, 4K TVs and more!
You can subscribe to us through iTunes and you can still access it directly through the RSS page HERE.
The URL for the podcast is: http://pcper.com/podcast - Share with your friends!
- iTunes - Subscribe to the podcast directly through the iTunes Store
- RSS - Subscribe through your regular RSS reader
- MP3 - Direct download link to the MP3 file
Hosts: Ryan Shrout, Jeremy Hellstrom, Josh Walrath, and Allyn Malventano
Program length: 1:16:34
0:01:20 Update on Indiegogo: You guys rock!
Week in Review:
0:06:30 AMD Radeon HD 7990 6GB Review
News items of interest:
0:48:45 ASUS RAIDR Teases keep happening
0:52:00 Western Digital Xe HDDs SAS
0:59:00 Raja Koduri returns to AMD
1:01:30 More Never Settle games??
1:02:45 Sound Blaster still a thing?
Ryan: Seiki 4K TV - more support from enthusiasts! and wet puppies
Jeremy: This is not news people, NFC is a feature but if you are paranoid you can check with this app
Josh: The hoarder in me wants one!
Allyn: Put your bits on an ioSafe. Put your 'papers' here.
Tim: BT Sync, it's in public alpha now so go grab it!
1-888-38-PCPER or firstname.lastname@example.com
Jaguar Hits the Embedded Space
It has long been known that AMD has simply not had a lot of luck going head to head against Intel in the processor market. Some years back they worked on differentiating themselves, and in so doing have been able to stay afloat through hard times. The acquisitions that AMD has made in the past decade are starting to make a difference in the company, especially now that the PC market that they have relied upon for revenue and growth opportunities is suddenly contracting. This of course puts a cramp in AMD's style, but with better than expected results in their previous quarter, things are not nearly as dim as some would expect.
Q1 was still pretty harsh for AMD, but they maintained their marketshare in both processors and graphics chips. One area that looks to get a boost is that of embedded processors. AMD has offered embedded processors for some time, but with the way the market is heading they look to really ramp up their offerings to fit in a variety of applications and SKUs. The last generation of G-series processors were based upon the Bobcat/Brazos platform. This two chip design (APU and media hub) came in a variety of wattages with good performance from both the CPU and GPU portion. While the setup looked pretty good on paper, it was not widely implemented because of the added complexity of a two chip design plus thermal concerns vs. performance.
AMD looks to address these problems with one of their first, true SOC designs. The latest G-series SOC's are based upon the brand new Jaguar core from AMD. Jaguar is the successor to the successful Bobcat core which is a low power, dual core processor with integrated DX11/VLIW5 based graphics. Jaguar improves performance vs. Bobcat in CPU operations between 6% to 13% when clocked identically, but because it is manufactured on a smaller process node it is able to do so without using as much power. Jaguar can come in both dual core and quad core packages. The graphics portion is based on the latest GCN architecture.
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Bullock plays Dr. Ryan Stone, a brilliant medical engineer on her first shuttle mission, with veteran astronaut Matt Kowalsky (Clooney) in command of his last flight before retiring. But on a seemingly routine spacewalk, disaster strikes. The shuttle is destroyed, leaving Stone and Kowalsky completely alone—tethered to nothing but each other and spiraling out into the blackness.
The deafening silence tells them they have lost any link to Earth…and any chance for rescue. As fear turns to panic, every gulp of air eats away at what little oxygen is left.
But the only way home may be to go further out into the terrifying expanse of space.
Gravity took top honors last night at the 15th Annual Golden Trailer Awards. 17 trophies were handed out live in Beverly Hills at the Saban theater, while a total of 75 different awards were bestowed upon the best trailers for movies, TV, and video games.
Columbia Pictures/Vibe Creative, Inc.Read More
It may be a day late, as April Fool's was yesterday, but a newly discovered alternate opening scene from the sci-fi smash hit drama Gravity has arrived online, and it features none other than a cameo from the Man of Steel himself Superman (Christopher Reeve). Watch as the DC Comics superhero helps Sandra Bullock and George Clooney out of a tough jam in a scene that was ultimately rejected by the executives at Warner Bros. Kal-El's involvement drastically changes the course of the entire storyline. Oh, and stick around until the very end, as the stinger makes the whole thing worthwhile.
Gravity was released October 4th, 2013.Read More
IMAX Corporation and Warner Bros. Pictures, a division of Time Warner Inc., today announced that Gravity has passed the $100 million global box office benchmark in 639 IMAX 3D theatres worldwide since its initial release Thursday, Oct. 3, 2013. As of Feb. 5, 2014, the film had reached $48.6 million in 330 IMAX 3D theatres domestically and $51.5 million from 309 theatres internationally. Gravity represents the third IMAX Hollywood film to cross the $100-million threshold, following Avatar in 2010 and The Dark Knight Rises in 2012.
Gravity continues to pull moviegoers in to IMAX theatres, with a Jan. 31, 2014, re-release into 330 IMAX 3D locations in North America and other international territories.Read More
The 25th Annual Producers Guild of America Awards were handed out last night, with Gravity and 12 Years a Slave tying for the guild's top honor, the The Darryl F. Zanuck Award for 'Outstanding Producer of Theatrical Motion Pictures'. Some guilds do not allow for ties to happen, and this is the first time in the PGA's history that it has happened for their biggest award.
Take a look at the rest of the big winners below, which were announced at the Beverly Hilton Hotel.Read More
Experience space like never before in the Academy Award-nominated Gravity, arriving onto Blu-ray 3D Combo Pack, Blu-ray Combo Pack, DVD and Digital HD on February 25 from Warner Bros. Home Entertainment. A heart-pounding thriller starring Academy Award winners Sandra Bullock (The Blind Side) and George Clooney (Syriana), and stunningly directed by Academy Award-nominee Alfonso Cuarón, Gravity pulls you into the infinite and unforgiving realm of deep space.
Gravity was written by Alfonso Cuarón and Jonás Cuarón and produced by Alfonso Cuarón and David Heyman (the Harry Potter films), with Christopher DeFaria, Nikki Penny and Stephen Jones serving as executive producers.Read More
Following its 10 Academy Award nominations earlier today, IMAX and Warner Bros. announced that the hit sci-fi thriller Gravity will be re-released in IMAX 3D theaters nationwide on January 31. The film is already slated for a second run in over 900 conventional theaters starting tomorrow, January 17. In addition, Warner Bros. has provided us with new photos featuring stars Sandra Bullock and George Clooney. Take a look at these images, then check out the official press release with more details on the re-release.
IMAX Corporation and Warner Bros. Pictures, a division of Time Warner Inc., today announced that Alfonso Cuarón's Gravity, one of the most popular films ever offered in IMAX 3D, will be returning to domestic IMAX theatres starting Jan. 31.Read More
http://movieweb.com/alfonso-cuaron-receives-2014-visionary-award-from-the-vfx-society/Yesterday, the Visual Effects Society (VES) named acclaimed filmmaker Alfonso Cuarón the recipient of its Visionary Award in recognition of his extraordinary career, most recently including his landmark achievement on this year's hugely successful sci-fi thriller Gravity. To celebrate, Warner Bros. has released a new behind-the-scenes 'making of' featurette that takes fans deep into the production process of this nail-biter about two astronauts (Sandra Bullock and George Clooney) stranded in space. Warning: Those who have not yet seen Gravity, which has taken in over $652 million at the box office, might want to wait before they settle in for this mini-documentary. As the end spoils the thrilling climax of the actual movie itself. If you're already a fan, settle in for a look at how this 2013 masterpiece came together.
The VES award will be presented to Alfonso Cuarón at the 12th Annual VES Awards on February 12, 2014 at the Beverly Hilton Hotel.Read More
Be warned, if you haven't seen the sci-fi thriller Gravity yet, there will be plenty of spoilers throughout this story. Gravity co-writer Jonás Cuarón, the son of director Alfonso Cuarón, has written and directed a seven-minute short film entitled Aningaaq, which ties into the blockbuster that just passed $500 million worldwide. This short shows us the other side of Dr. Ryan Stone's (Sandra Bullock) distress call made from the Russian space station, where she makes contact with a man speaking an unidentified foreign language. Aningaaq centers on the Inuit fisherman in Greenland who answers her call. Check out the video, then read on for more information.
The short film was initially set to be included in the Gravity Blu-ray and DVD release, but now, after festival screenings in Telluride and Venice, Warner Bros. is submitting Aningaaq for Oscar consideration in the Best Live-Action Short category. If both Aningaaq and Gravity are nominated, it would be the first time that both a feature and short derived from the same material are nominated in the same year.Read More


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Youtube August trailers.
Just in case someone wants to watch the trailer full-screen on youtube, we have posted it up over here: http://www.youtube.com/watch?v=cQrA5b_dAjk. The gametrailer version should be up soon. If someone feels like spreading the word please fee freel to submit the trailer to other websites as well.
Awesome, thanks. Added to Dofsource.
Wonderful trailer. :D
I thought the Xbox logo was interesting. But an Xbox version isn't confirmed, right? Doesn't it all depend on the success of the PC version?
The game looks better every time i watch the trailer :D This means that love blinds me (and i really love DoF :P) or that i notice more details the more i watch it...have u worked on the animations? They look far more fluid compared to the unofficial trailers some months ago
I just saw the trailer and I must say that it was amazing! The season changes looked really good especially the snow. The whole thing looked really realistic and the graphics still looked great even though they aren't completely finished. Keep up the awesome work and thank you.
Its amazing and really has got the classic fantasy feel while being very new at the same time
indeed the trailer looks really really good, almost too good..restrained concern in check, I'm going to link the trailer on another forum where at least a few dedicated fantasy rts players will find this introduction unexpectedly enticing.
wow that looks amazing :O
Amazing trailer. Looks really great. Thanks for the post. I'm so hyped on this game and so are my friends xD. Can't wait!
great trailer! love the giant "ent like" creatures @ 0:58.
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iNsAniTy by MomoHinomoriWatch
©2013-2016 MomoHinomori
If you have ever played hetaoni or watched a walkthough you'll know that if you make Japan play the piano he will play the song Insanity~ haha one time I made him play the piano countless times because I love hearing the song and he found a key o.0 wasn't expecting that also if you make him go to the lybrary on the third floor and go to the top bookshelf near the wall he'll find a dirty book~ XD
HetaOni is awesome! And you get the feels. So is this picture
I played Hetaoni. Best.Game.Ever. I actually almost cried at certain points.
This picture is just awesome
This picture is just awesome


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- Age / Gender:
- 26, Male
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- Myrtle Beach, SC
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- 4/24/05
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Flash? Hell no; I can't create flash. Submit audio? Are you serious!? The best I've done is a mash up of Mercy and Walk on Green, and even it's not so great.
Art? Now there's something I can do! It's been over half a decade, but I can finally contribute something to NG that isn't a BBS post!!! Check out my recent postings! :)
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Total Medals Earned: 41 (From 9 different games.)
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|Classical Song
|Classical Song
|no is the new yes
|Drum N Bass Song
|Frog's Piano -XvN-
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Favorite Movies
"Winter" Rated 4.2131 Stars Is cold. BRRRR fuck Other Dendyn Dynasties Rated 4.4129 Stars Hypo anthro violence from a world where RPG cliches are real! Action Submit Rated 4.1384 Stars To Submit is to risk all... Other Arfenhouse Teh Movie 4!!! Rated 4.3887 Stars Arfenhouse The Movie 4 Comedy - Original
Favorite Games
Cherry Cola Rated 3.5551 Stars Lead the little Cherry Cola to his way! Puzzles - Other Exmortis Rated 4.2674 Stars Exmortis - Point and Click Horror Adventure Game Adventure - Point 'n Click StickRPG *Complete* Rated 4.3297 Stars Stick RPG Complete; The highly anticipated completion of a cult classic. Adventure - RPG Flash Halo: CTF Rated 3.1401 Stars Play Capture The Flag at Blood Gulch, in this 2D Halo remake!! Action - Shooter - Run 'n Gun


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Fritz Chess 13
I think you should burn a DVD with the game and run it from your DVD rom.
Even so,why you dont unpack your wmv files and watch them in VLC?
I managed to obtain a file named F13setup.exe from the temporary files folder during the installation process. Then I unpacked the exe with winrar like you said and had my wmv files.
Thank you.
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text: 10.3886/ICPSR03515.v1 United States Department of Commerce. Bureau of the Census School District Geographic Reference File, 1969-1970 Inter-university Consortium for Political and Social Research 2002 census data census divisions census tract level congressional districts Metropolitan Statistical Areas minor civil divisions population density school districts 2002-11-14 2002-11-14 1969--1970 census/enumeration data 3515 1 The geographic cross-reference files have been created to allow the user to prepare additional data summaries relevant to school districts. Another use for the geographic cross-reference files is to provide the ability to equate detailed record files having school district codes with census geographic units. This capability could be used to relate administrative record summaries with census geographic data. This data collection is a school district georeference file collected during 1969-1970 that has been instrumental in aggregating First Count Summary Data by school district and can be used in interpreting the School District First Count file. This file does not contain data for the State of Maryland. Variables include state, county, minor civil division (MCD), MCD-place, census tract, block group, enumeration district (ED), population of block group, school district code, school district type, percentage of population in school district, place description, congressional district, school district name, grade range, standard metropolitan statistical area (SMSA), and government ID code.


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Bethlehem, a gripping, slam-bang thriller screening as part of the 17th Annual Miami Jewish Film Festival, opens and closes amid expansive, arid backdrops. If they're meant to convey the vast divide that alienates the clashing Palestinian factions living in the movie's titular city from each other, director/co-screenwriter Yuval Adler doesn't dwell on them for too long. The bulk of his tightly plotted spy yarn unfolds in narrow streets, cramped houses and bustling offices. The overarching effect is claustrophobia, as Adler's restless camera follows the impulsive, short-tempered men caught up in a potent morality play.
Adler's film is one of several sold-out screenings at this year's MJFF, the maiden voyage for new festival director Igor Shteyrenberg. (Fear not; there will be a rush line.) He has put together a promising lineup that combines hard-hitting chronicles like Bethlehem and Lucía Puenzo's Josef-Mengele-in-Argentina potboiler The German Doctor with lighter fare like When Comedy Went to School, the documentary that opens the festival. This documentary takes a look at how the Catskills Mountains served as a training ground for then-up-and-coming stand-up comedians like Jerry Lewis and Sid Caesar. A thematic kindred spirit to this film is When Jews Were Funny, a documentary that traces the history of Jewish comedy and features interviews with Howie Mandel and Gilbert Gottfried. Perhaps the screening I'm anticipating the most is a special 30 anniversary showing of Woody Allen's Broadway Danny Rose introduced by filmmaker Whit Stillman (Metropolitan, Damsels in Distress). The festival runs Jan. 23 to Feb. 3 at several area theaters.
Bethlehem is the only film I had a chance to see in advance by press time, and I'm glad I did. Instead of the high-minded treatise of Israel-Palestine strife I was expecting, Adler has made a lean and mean B movie, and yes, in this case that is most definitely a compliment. Working from a screenplay he co-wrote with Ali Wakad, Adler has filled his trust-no-one tale with people who not always think before they act. Take, for instance, wet-kitty-faced Sanfur (Shadi Mar'i). In the sullen teen's defense, if you were stuck being an informant for the Israeli Secret Service while your older brother just masterminded a suicide bombing, chances are you'd be in a dark place, too. And it's not as if he dislikes his handler, hunky, almond-eyed Razi (played by hunky, almond-eyed Tsahi Halevi), who has become attached to the lad and doesn't feel comfortable using him to nab his terrorist sibling. Razi's boss reminds him their suspect, who is hiding in Jerusalem, will probably strike again. "He's murdered 30 Israelis and you're worried about his brother?" his superior asks Razi in disbelief.
None too subtly conveyed in that remark is long-simmering contempt for the Palestinians Razi has befriended while on the job. Thankfully, though, Adler does not set out to make an issue movie, ensuring the social-problem trappings serve the genre-driven plot, not the other way around. When Adler adds corrupt government officials, resentful al-Aqsa brigades, and entitled Hamas soldiers to the mix, and the result is a pulpy powder keg of a movie that's propelled by a sense of urgency. It might be set in the Middle East, but Bethlehem's tense conflicts bring to mind the warring families in mob sagas, as well as the rites of passage depicted in inner-city coming-of-age dramas from the 90s. Which is to say Adler's fully aware of the gravity of his subject matter but does not allow the severity of the stakes to drown out the action.
The film's centerpiece is a skillfully executed raid that pits Israeli forces against a hostile street crowd with the fate of Sanfur's brother hanging in the balance. Like the rest of Bethlehem, the sequence is crisp, shot with storytelling economy and a knack for knowing not to overstay its welcome. Such is Adler's focus that Razi's personal life, apart from the paternal instinct for his young informant, remains on the sidelines. The filmmaker is far more interested in how the Israeli presence in Bethlehem affects the already-fraught relationships between the city's Palestinian leaders. Most captivating of all is al-Aqsa Badawi (scene-stealing Hitham Omari), who sees in Sanfur an opportunity to make a power play.
Bethlehem rushes toward a climactic confrontation that, on paper, seems inevitable, but which Adler stages with a disquieting sense of uncertainty. He's made a taut portrait of Mideast tensions in which brutality and tenderness coexist in uneasy disharmony.
As far as dysfunctional, self-destructive characters go, I far preferred the nest of vipers Adler introduces over the broken household at the core of The Past, the highly anticipated second feature from Iranian filmmaker Asghar Farhadi, who won a Foreign Language Oscar two years ago for A Separation. A crumbling home is once again his point of departure, but this time it's a multi-ethnic clan living in France. Ahmad (Ali Mosaffa) and Marie (The Artist's Bérénice Bejo) have been separated since Ahmad went back to Iran. She has two daughters from a prior marriage, and now things are really beginning to get serious with current beau Samir (A Prophet's Tahar Rahim). Now Ahmad has returned to finalize divorce proceedings so that they can all move on with their lives.
Or can they? Ahmad arrives from the airport to find a home in shambles. Samir's son acts out in the most annoying ways possible, and Lucie, Marie's older daughter, rebels against her mom for what she perceives is immature behavior. (Pot, meet kettle.) Ahmad, a collected presence amid all this chaos, attempts to restore a semblance of order, something that rubs Samir the wrong way. I have to agree with the new boyfriend. Ahmad's a bit of a self-satisfied tool, but so is everyone else Farhadi has written. The film unfolds as a series of conversations between the estranged characters, and instead of flowing steadily like in A Separation, the narrative becomes stagnant as Farhadi shifts from different characters' point of view. Rather than finding insight into this complicated characters' lives, the snippy arguments turn The Past into a chore to sit through.
Even more dispiriting, Farhadi remains obsessed with periodically doling out pieces of information that force viewers to constantly reexamine their perception of these baggage-saddled souls, something that came across as a neat storytelling device in A Separation but here feels synthetic, overly programmatic. Long before a haunting final scene turns it into even more of a downer than it already is, The Past OD's on its all-is-not-as-it-seems reveals, reducing its characters to pawns on a chessboard serving Farhadi's ambitious narrative pirouettes. The film is nevertheless a beautifully acted portrait of domestic malaise. It's also joyless and unremittingly grim. A little more levity, and fewer wet blankets on screen, would have worked wonders.
The Past opens Jan. 24 at Regal Cinemas South Beach and the Classic Gateway Theatre (thegatewaytheatre.com). Bethlehem screens Jan. 28, also at Regal South Beach. For more information go to miamijewishfilmfestival.com.


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Publications (206)385.69 Total impact
Article: [The diagnostic value of pre-biopsy magnetic resonance imaging for precise detection of clinically localized prostate cancer compared to post-biopsy setting][Show abstract] [Hide abstract]
ABSTRACT: A total of 136 patients who underwent radical prostatectomy following histological diagnosis of prostate cancer by transrectal biopsy and 3-Tesla magnetic resonance imaging (MRI) were evaluated. MRI was performed on 26 patients before prostate biopsy (pre-biopsy group) and on 110 patients after prostate biopsy (post-biopsy group). We defined the largest tumor focus in a radical prostatectomy specimen as the index cancer. We compared the accuracy of MRI in detecting and localizing the index cancer in the groups. The sensitivity of detecting the index cancer by MRI was significantly (p=0.012) higher in the pre-biopsy group (96.2%) than in the post-biopsy group (77. 3%). The negative predictive value of extracapsular invasion was 84.6% in the pre-biopsy group and 80.7% in the post-biopsy group. The average interval between biopsy and MRI was 42.8 days. Artifacts due to post-biopsy hemorrhage were observed in 32 (29.1%) of the patients in the post-biopsy group. The sensitivity of detecting the index cancer by MRI was significantly (p=0.022) higher in 78 patients without artifacts due to hemorrhage (83.3%) than in the 32 patients with artifacts due to hemorrhage (62.5%). Even if MRI is delayed until after prostate biopsy,the artifact due to hemorrhage markedly interferes with the accuracy of MRI. Although pre-biopsy MRI is more accurate than post-biopsy MRI,there are some problems to be solved,such as cost effectiveness and the detectability of low-malignant and small cancers.
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ABSTRACT: Salvage urethroplasty after failed repair of traumatic urethral injury is a urological challenge, and we herein describe our experience with it. From October 2010 to January 2012, five patients underwent salvage repair of failed urethroplasties for traumatic urethral injuries: three bulbar straddle injuries and two pelvic fracture urethral injuries. One of the three failed urethroplasties for bulbar straddle injuries was a stricture excision and primary anastomosis, and its failure was due to periurethral abscess formation. Another was an augmented anastomotic urethroplasty using buccal mucosa, and its failure was due to periurethral abscess formation. The third was a tube graft urethroplasty using buccal mucosa, and its failure was due to a stricture at the anastomotic site. Two failed urethroplasties for pelvic fracture urethral injuries were perineal anastomotic repairs combined with corporal separation and inferior pubectomy, and the failures of both were due to ischemic bulbar necrosis. The urethral gap lengths estimated from urethrograms ranged from 12 to 45 mm (mean = 26 mm). Urethroplasties in all patients with bulbar straddle injuries were salvaged by stricture excision and primary anastomosis with corporal separation, and urethroplasties in both patients with pelvic fracture urethral injuries were salvaged by abdominal transpubic perineal urethroplasty. Although the patients who underwent transpubic urethroplasty had transient pelvic girdle pain, no severe complications were observed. All patients were for 10 to 25 months postoperatively (mean = 16 months) able to void satisfactorily without additional treatment. Failed urethroplasties for traumatic urethral injuries can be salvaged with a second reconstruction surgery. The procedure of choice for this salvage is anastomotic urethroplasty with techniques for tension-free anastomosis.
Article: Increased expression of α-actinin-4 is associated with unfavorable pathological features and invasiveness of bladder cancer[Show abstract] [Hide abstract]
ABSTRACT: In the present study, the association between clinicopathological parameters and α-actinin-4 (ACTN4) expression in bladder cancer specimens was evaluated, and the functional role of ACTN4 in bladder cancer cells was investigated. Immunohistochemistry using anti-ACTN4 antibody was performed in bladder cancer specimens (53 superficial and 42 muscle-invasive cases) from 95 patients who underwent radical cystectomy (n=46) or transurethral resection (TUR) only (n=49). We divided the levels of ACTN4 expression into 2 groups (low or high) by comparing the staining intensity in each specimen with that of the vascular endothelial cells in the same specimen, and we evaluated the correlations between these levels and pathological parameters, recurrence and prognosis. We also investigated the effects of ACTN4 suppression by siRNA on the invasive ability and proliferation of T24 and KU19-19 cells. High ACTN4 expression was significantly associated with higher tumor grade and higher pT stage. In patients with superficial bladder cancer treated only by TUR, the rate of intravesical recurrence did not differ significantly between patients with high ACTN4 expression and patients with low ACTN4 expression. In patients who had muscle‑invasive tumors and underwent radical cystectomy, high ACTN4 expression was associated with neither recurrence nor poor prognosis. Nonetheless, high ACTN4 expression was shown by a large percentage (81%) of patients with muscle-invasive bladder cancer and by a small percentage (17%) of patients with superficial bladder cancer. Furthermore, the leading edges of the invasive bladder cancer showed increased ACTN4 expression. ACTN4 suppression significantly reduced the number of invading bladder cancer cells but unexpectedly increased the proliferation of bladder cancer cells. ACTN4 suppression increased the phosphorylation of ERKs but not AKT or STAT3, suggesting that the increased proliferation due to ACTN4 suppression was mediated in part by the ERK pathway. ACTN4 expression may suppress the proliferation of bladder cancer cells and may produce conditions which facilitate cancer cell invasion.
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ABSTRACT: Direct vision internal urethrotomy (DVIU) has been considered to be a low invasive and widely used therapeutic modality for male urethral stricture. However, its efficacy is still controversial. We herein evaluated the efficacy of DVIU for male urethral stricture. Nineteen patients 27 to 78 years old (median age = 59) underwent DVIU for urethral strictures at our hospital were included in this study. Strictures were at bulbar urethra in 17 patients, membranous urethra in 1 patient, and pendulous urethra in 1 patient. The stricture lengths estimated on retrograde urethrography were less than 1 cm in 13 patients, 1-2 cm in 2 patients, and more than 2 cm in 4 patients. The etiology of stricture was straddle injury in 7 patients, post transurethral surgery in 7 patients, pelvic fracture in 1 patient, and unknown in 4 patients. The operation was done by cold knife incision using guidewire. The duration of postoperative urethral catheterization was 5 to 35 days (mean 12.8 days). Follow up duration ranged from 1 month to 139 months (mean 48.2 months). The definition of postoperative re-stricture was the confirmation of re-stricture on retrograde urethrography or deterioration of symptom. While no severe complication was observed, postoperative re-stricture was seen in 13 patients. Stricture-free rates at 3 months, 6 months, and 5 years after the first DVIU were 44.4%, 38.1%, 20.3% respectively. Although second DVIU was done for 7 patients with re-stricture, six patients resulted in failure. Stricture-free rates at 3 months, 6 months, and 5 years after the second DVIU were 42.2%, 28.6%, 14.3% respectively. Though the third DVIU was done for two of them, they were unable to void just immediately after the removal of urethral catheters. Stricture-free rate in stricture less than 1 cm was higher than that in 1 cm or longer, though it did not reach significant difference (p = 0.1813). The efficacy of DVIU is lesser than we expected. DVIU seems to be excessively applied to male urethral strictures and should not be performed for long and recurrent urethral stricture.
Article: Impact of increased erythropoietin receptor expression and elevated serum erythropoietin levels on clinicopathological features and prognosis in renal cell carcinoma[Show abstract] [Hide abstract]
ABSTRACT: Erythropoietin (EPO) expression and EPO receptor (EpoR) expression have been demonstrated in various malignant tumors. EPO-EpoR signaling can activate several downstream signal transduction pathways that enhance tumor aggressiveness. The present study was undertaken to evaluate the impact of overexpression of EpoR and elevated serum EPO (sEPO) levels on the clinicopathological features and prognosis of patients with renal cell carcinoma (RCC). EpoR expression was evaluated immunohistochemically in 56 patients. Tumors with a staining intensity greater than that of surrounding proximal tubules were defined as tumors with high EpoR expression. The association between EpoR expression levels and various clinicopathological factors was analyzed. sEPO levels were determined in 138 patients and its correlation to clinicopathological factors was also analyzed, and EpoR expression was determined in surgical specimens removed from 47 of those 138 patients. Patients with high EpoR expression and patients with sEPO elevation had clinicopathological features less favorable than those of other patients. Tumors demonstrating high EpoR expression had a significantly higher number of Ki-67-positive cells compared to those with low EpoR expression. Tumor assemblies in microvessels demonstrated high EpoR expression. Patients whose tumors demonstrated high EpoR expression and those with sEPO elevation had a significantly lower survival rate compared to other patients, and patients with both high EpoR expression and sEPO elevation had an extremely poor prognosis. Microvascular invasion was an independent factor associated with sEPO elevation, suggesting that EPO-EpoR signaling might be important in RCC metastasis. EPO-EpoR signaling may be involved in tumor growth and progression in RCC and the combination of EpoR expression and sEPO levels may effectively predict clinical outcome.
Article: 698 LOW LEVELS OF SERUM OMEGA-3 POLYUNSATURATED FATTY ACID ARE ASSOCIATED WITH TUMOR AGGRESSIVENESS AND POOR PROGNOSIS IN RENAL CELL CARCINOMA
Article: Glucose-Regulated Protein 78 Positivity as a Predictor of Poor Survival in Patients with Renal Cell Carcinoma[Show abstract] [Hide abstract]
ABSTRACT: Glucose-regulated protein 78 (GRP78), a chaperone for newly formed proteins during folding and glycosylation, is associated with resistance to apoptosis in some forms of cancer. We assessed GRP78 expression and its correlation with clinicopathological parameters and survival. Immunohistochemistry was performed using formalin-fixed, paraffin-embedded specimens: 128 primary renal cell carcinoma (RCC) specimens (120 conventional and 8 other cell types) and 9 metastatic specimens. GRP78 positivity was determined based on intensity of staining and percentage of cells stained. Correlation of GRP78 positivity with clinicopathological parameters including patients' survival was evaluated. A statistically significant association was found between GRP78 positivity and higher tumor grade (G3; p <0.0001), advanced T stage (≥pT3; p = 0.0002), lymphovascular invasion (positive; p <0.0001), regional nodal involvement (≥N1; p = 0.0086), and distant metastases at presentation (M1; p = 0.001). Positivity of GRP78 expression was significantly associated with shorter disease-specific survival and shorter progression-free survival. Cox proportional hazard model showed that strong GRP78 positivity was an independent predictor of shortened progression-free survival in N0M0 RCC patients. There was a significant relationship between GRP78 expression levels and aggressiveness of RCC. Increased expression of GRP78 might be a useful parameter to predict shortened survival in patients with RCC.
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ABSTRACT: Perioperative results and oncological and functional results were evaluated for 52 patients who underwent laparoscopic radical prostatectomy (LRP). Median operative time was 341 minutes and median blood loss was 828 ml. The intraoperative complications were hemorrhage exceeding 3,000 ml (five cases), ureteral injury (two cases), and rectal injury (one case). The median day of catheter removal was postoperative day 7. Postoperative complications were temporal arrhythmia, mild hydronephrosis, port site hernia, urethral stricture, and a giant lymphocele. When surgical results were compared between the firsthalf cases and second-half cases who were operated on by a single surgeon, median operative time and intraoperative hemorrhage did not differ significantly between the two halves but the day of catheter removal after LRP was significantly earlier for the second-half group. The pathological stage was pT3 in 41.2% of the patients and the negative surgical margin rate was 62.7%. The 3-year PSA-failure-free survival rate was 64. 1%. Pad-free status (0-1 pad/day) was achieved in 84.4% of the patients. Erectile function was preserved in 58.3% of patients undergoing nerve-sparing LRP. Although the complication rate and the quality of operative procedures gradually improved, efforts to improve the oncological and functional outcomes of LRP must continue.
Article: 382 HEAT SHOCK PROTEIN 27 OVER EXPRESSION IS AN INDICATOR OF TUMOR AGGRESSIVENESS AND POOR PROGNOSIS IN RENAL CELL CARCINOMA
Article: 229 INHIBITION OF THE GROWTH AND TUMOR ANGIOGENESIS OF RENAL CELL CARCINOMA BY THE STAT3 INHIBITOR WP1066
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ABSTRACT: A 75-year-old woman was referred to our department for evaluation of a left renal tumor. Computed tomography and other imaging studies demonstrated a left renal mass and tumor extension into the left renal vein passing caudally behind the aorta. We clinically diagnosed the tumor as renal cell carcinoma (RCC) associated with a retroaortic left renal vein thrombus, and performed a radical nephrectomy. Pathological examination of the surgical specimen showed a grade 2, clear cell carcinoma with a renal vein thrombus and negative surgical margin. Retroaortic left renal vein is a rare anomaly with a prevalence of 1.8-2.4%. RCC associated with a retroaortic left renal vein thrombus is rarer still. To our knowledge, this is only the third case report to describe an RCC associated with a tumor thrombus in the retroaortic left renal vein.
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ABSTRACT: A 73-year-old male patient with hypertension and hyperglycemia was referred to our hospital because of a diagnosis regarding his left adrenal tumor. Because the levels of urinary metanephrine and normetanephrine were elevated, and (131) I-MIBG scintigraphy showed intense uptake in the adrenal tumor, the tumor was diagnosed as a pheochromocytoma. An adrenalectomy was carried out. Severe polyuria, which was accompanied by a rapid decrease in central venous pressure, started 1 hour after the operation. Urine output of more than 8000 mL/day continued until the 16th postoperative day. Plasma antidiuretic hormone (ADH) levels were within the normal range. Plasma human atrial natriuretic peptide (hANP) and brain natriuretic peptide (BNP) were elevated postoperatively, and the elevation of these peptides was one possible cause for the severe polyuria. Because ADH levels in the tumor fluid were not elevated, the tumor was not an ADH-secreting tumor. Urinary β2-microglobulin was significantly elevated after the operation, thus suggesting that renal tubule dysfunction might also have been involved in the polyuria. However, the mechanism of polyuria after the resection of adrenal pheochromocytoma is not fully understood. Polyuria after the resection of adrenal pheochromocytoma is extremely rare, and the present subject is the second case to date.
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ABSTRACT: We report a rare case in which upper ureteral rupture was the primary symptom of malignant lymphoma. A 74-year-old female visited our hospital with left flank pain. Computed tomography showed urinoma around the left kidney and retrograde pyelography showed a diffuse filling defect in the left ureter and a rupture of the upper portion of that ureter. A urine cytology specimen from the left ureter was class V, suggesting undifferentiated carcinoma or malignant lymphoma. An open laparotomy revealed a nodule on the omentum and diffuse fibrosis around both ureters, and the histopathological diagnosis was diffuse large B-cell lymphoma. The patient' s ureteral stenosis disappeared after she received six cycles of R-CHOP (cyclophosphamide, doxorubicin, vincristine, prednisolone and rituximab) chemotherapy. We should be aware that malignant lymphoma can be the cause of a spontaneous ureteral rupture.
Article: Clinical experience of treatment of liver metastasis of renal cell carcinoma treated with SMANCS/Lipiodol therapy[Show abstract] [Hide abstract]
ABSTRACT: The treatment for metastatic renal cell carcinoma (RCC) has changed dramatically after the beginning of molecular-targeted therapies. However,the treatment for liver metastasis is still difficult in patients with metastatic RCC. We treated liver metastases (8 target lesions) of RCC with stylene-maleic acid neocarzinostatin (SMANCS)/Lipiodol therapy. At the treatment procedure,a catheter was inserted at the femoral artery (Seldinger's method),a microcatheter was selectively inserted into the branch of hepatic artery which fed the liver metastasis,and then SMANCS/Lipodol was infused. We treated 1,2 and 1 patient 4,2, and 1 time,respectively. One lesion treated with SMANCS/Lipodol was further treated by radiofrequency ablation 13 days later. Of 6 metastatic lesions which could be followed up for more than 6 months after the treatment,one had partial response for 4 months and 4 had stable disease for more than 6 months. Four of the 6 lesions shrunk after SMANCS/Lipiodol treatment. Two of 4 patients survived more than 18 months after the first SMANCS/Lipiodol therapy. In all 9 SMANCS/Lipiodol treatments,grade 1 liver dysfunction (44.4%),ascites (11.1%) and fatigue (11.1%) occurred after the treatments. These adverse events were all improved by conservative treatments. SMANCS/Lipiodol therapy can be a treatment option as local treatment for liver metastasis of RCC.
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ABSTRACT: We report a rare case of primary amelanotic malignant melanoma of the female urethra. A 58-year-old female with complaint of nodule on the external urethral meatus was referred to our hospital. Pathological diagnosis of the biopsy specimen from the nodule was malignant melanoma. Computed tomography of the chest and abdomen as well as bone scan showed no evidence of metastasis. Sentinel biopsy from the inguinal lymph nodes revealed no metastasis. Thereafter, the patient underwent radical urethrectomy, whose limits of resection were the bulbocavernosal muscles bilaterally, the arch of the pubic symphysis anteriorly, the anterior vaginal wall posteriorly, and the urethra up to the level of the bladder neck superiorly. The histopathological diagnosis was amelanotic malignant melanoma of the urethra. The patient had received six cycles of DAV-Feron (dacarbazine, nimustine, vincristine, and interferon-beta) in an adjuvant setting, and there is no sign of recurrence 25 months after operation.
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ABSTRACT: Signal transducer and activator of transcription 3 (STAT3) regulates the expression of genes that mediate cell survival, proliferation, and angiogenesis and is aberrantly activated in various types of malignancies, including renal cell carcinoma (RCC). We examined whether it could be a novel therapeutic target for RCC by using the STAT3 inhibitor WP1066. The antitumour activities and related mechanisms of WP1066 were investigated in vitro on renal cancer cell lines and in vivo on murine xenografts. In Caki-1 and 786-O renal cancer cells, 5 muM WP1066 prevented the phosphorylation of STAT3, and 2.5 muM WP1066 significantly (P<0.01) inhibited cell survival and proliferation. WP1066 suppressed the expression of Bcl-2, induced apoptosis, and inhibited the basal and hypoxia-induced expression of HIF1alpha and HIF2alpha, as well as vascular endothelial growth factor secretion into cell culture medium. Human umbilical vascular endothelial cells cocultured with media from WP1066-treated cells showed significantly reduced tubulogenesis (P<0.05). Systemic oral administration of WP1066 to mice for 19 days significantly inhibited the growth of Caki-1 xenograft tumours (P<0.05), and pathological analysis of xenografts of WP1066-treated mice showed decreased immunostaining of phosphorylated STAT3 and reduced length of CD34-positive vessels (P<0.05). Our results suggest that using WP1066 to inhibit the STAT3 signalling pathway could be a novel therapeutic strategy against RCC.
Article: 1850 PERITUMORAL LYMPHATIC VESSEL DENSITY IN PROSTATE BIOPSY CORES AS PREDICTOR OF LYMPHATIC INVASION IN SURGICAL SPECIMENS FROM RADICAL PROSTATECTOMY
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ABSTRACT: We evaluated the efficacy and outcome of one-stage oral mucosa graft urethroplasty, which is currently the procedure of choice for treating lengthy and complicated urethral strictures not amenable to excision and primary end-to-end anastomosis. Seven patients 33 to 74 years old (mean age = 53.7) underwent one-stage oral mucosa graft urethroplasty for a stricture in either the bulbar urethra (four patients), penile urethra (two patients), or pan-anterior urethra (one patient). Three of the strictures were due to trauma, one was due to inflammation, and one was due to a failed hypospadia repair. The other two were iatrogenic. All patients had previously undergone either internal urethrotomy or repeated urethral dilation. Three patients received a tube graft, three received a ventral onlay, and one received a dorsal onlay. A free graft of oral mucosa was harvested from the inside of each patient's left cheek, and if necessary to obtain a sufficient length, the harvest was extended to include mucosa from the lower lip and the right cheek. The graft lengths ranged from 2.5 to 12 cm (mean = 4.6 cm). A urethral catheter was left in place for 3 weeks postoperatively. While no severe complications at the donor site were observed during follow-up periods ranging from 3 to 55 months (mean = 14 months), two patients who had received a tube graft developed distal anastomotic ring strictures that were managed by internal urethrotomy. The other five required no postoperative urological procedure even though one who had received a ventral onlay developed a penoscrotal fistula. Oral mucosa is an ideal urethral graft, and oral mucosa graft urethroplasty is an effective procedure for repairing complicated urethral strictures involving long portions of the urethra.
Article: Adrenomedullin Increases Renal Nitric Oxide Production and Ameliorates Renal Injury in Mice With Unilateral Ureteral Obstruction[Show abstract] [Hide abstract]
ABSTRACT: We evaluated the effects of adrenomedullin (Peptide Institute, Minoh-shi, Osaka, Japan) on mediators, including nitric oxide and transforming growth factor-beta, and parameters of renal injury in a murine unilateral ureteral obstruction model. Three study groups of control, adrenomedullin treated and adrenomedullin plus L-NAME treated BALB/C mice, respectively, underwent left unilateral ureteral obstruction. A 24-hour urine sample was collected to measure urinary NO(2)/NO(3) 1 day before unilateral ureteral obstruction and kidneys were harvested on postoperative day 14. Tubulointerstitial damage markers were evaluated by immunohistochemistry. Tissue transforming growth factor-beta was determined by enzyme-linked immunosorbent assay. Endothelial and inducible nitric oxide synthase immunolocalization was also determined. Urinary NO(2)/NO(3) was significantly higher in the adrenomedullin group than in controls, confirming increased renal nitric oxide production. Immunohistochemistry showed increased endothelial nitric oxide synthase in vascular endothelial cells in the adrenomedullin group but tissue transforming growth factor-beta did not significantly differ in controls vs the adrenomedullin group. Interstitial collagen deposition and fibroblasts in the obstructed kidney were significantly decreased in the adrenomedullin group. The number of leukocytes and apoptotic cells in the obstructed kidney were significantly decreased by adrenomedullin. Renal injury amelioration resulting from adrenomedullin was blunted by the nitric oxide synthase inhibitor L-NAME. Adrenomedullin increased renal nitric oxide, and suppressed tubular apoptosis, interstitial fibrosis and inflammatory cell infiltration in mice with unilateral ureteral obstruction. The renoprotective peptide adrenomedullin may be useful for that condition.
Top Journals
National Defense Medical College
Tokorozawa, Saitama, Japan
- Division of Urology
Tokorozawa Central HospitalTokorozawa, Saitama, Japan
University of the Ryukyus
Okinawa, Okinawa, Japan
- • Department of Urology
- • Department of Medicine
Keio University
Edo, Tōkyō, Japan
- • Department of Urology
- • School of Medicine


text:
Need your help by LoveAsiaWatch
©2013-2016 LoveAsia
`~~..Okay guys i need your help xDD...tell me which character can i cosplay with my new wig??...Thank's for helping me ^^ <3333333333 ..~~``
Okay here you another pic of the wig... [link]
Okay here you another pic of the wig... [link]
how about Kise Ryouta from kuroko; or Usui Takumi from Maid-sama!; or Belphegor from KHR!; or Oz Vessalius from Pandora Hearts; or United Kingdom from Hetalia; or Toma from Amnesia; or Ali Baba Saluja from Magi; Kida Masaomi from Durarara!; Shyou Kurusu from Uta no prince-sama!; Kano Shuuya from Kagerou Project.
one of them should be a good choice, no?? :3
one of them should be a good choice, no?? :3
Alois Trancy yes, and Kise Ryouta from Kuroko no basket and Natsuki Shinomiya from Uta no Prince-sama
aha~ what about Shouichi Irie from Katekyo Hitman Reborn? though his hair is more darker or redder maybe...
i agree with that it does look like alois's wig
I think in that wig you look most like alois trancy from black butler. I think the costume would suit you very well


text:
25 Lessons I Wish I Had Learned WAY Sooner « Demanding...
When I think of my younger, thinner, stupider self, I think, "Holy crap. If I knew then what I know now…" Well, here are some of the things I wish I knew then.
Keywords: Humor, Environment, Bizarre/Oddities, Health, Alcoholic Drinks
When I think of my younger, thinner, stupider self, I think, "Holy crap. If I knew then what I know now…" Well, here are some of the things I wish I knew then.
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Watch BBC video clips about mid-ocean ridges that explain how these undersea volcanic mountain ranges create new sections of the tectonic plates.
Miniature Earth. What if the population of the world were reduced into a community of only 100 people?
When you're new to wine, one of the hardest things about choosing a bottle is remembering if a type is sweet, dry, light, bold, or somewhere in between. Use this handy chart anytime you need to remember that you're looking for a
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Republicans launched an unprecedented frontal assault against environmental protections and regulations this year, prompting Rep. Henry Waxman (D-Calif.) to call his chamber "the most anti-environment House in history." Here are the 10 most powerful ...
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This expansive graph by Online Education tells you all you need to know about bottled water, as you scroll from top to bottom. Now excuse me while I try to hide my bottle of water. Won't happen again, promise.[Via Online Education]
I wish i had one
Pen.io is down for maintenance - your existing Pen.io pages are still accessible
If you've ever had your penis cut off and/or been executed while on holiday, you'll probably know that it's easy to offend people from other cultures....
99ROOMS.COM - A Project of Kim Koester, Richard Schumann, Stephan Schulz and Johannes Buenemann
TwoFoods is an online food comparison tool that helps you choose healthy foods.
Well, my birthday just passed. I'm 25! Again! For the *mumble, mumble* time! I thought it might be a good time to reflect. So if I could talk some sense t
Funny pictures from LOLDaddy.com! Brings you new LOLs, every day :D
Free online jigsaw puzzles. Hundreds of new jigsaw puzzles every day created by users from all around the world.
Here are some interesting, but true facts, that you may or may not have known. 1. The Statue of Liberty's index finger is eight feet long. 2. Rain has


text:
Enjoy The Silence by IngoSchobertWatch
©2013-2016 IngoSchobert
Every time I find myself coming back to this photo, I am just in awe. All the colors in this photo all form perfectly around each other. From the sky to the pink and then to the neutrals on the ground. It is as if this scene plays a story out for you, just what it is saying is beyond words. Although it is photography it almost seems as if this place is unreal. I cannot think of anything I could say that is lacking in this photo. I can only say that I look forward to more work like this in the future. Great job!
The Artist thought this was FAIR
1 out of 1 deviants thought this was fair.
This lovely work has been featured in our weekly journal here: Abstract and Surreal Spotlight Vol. 22
Looking forward to seeing more art from you at #devPREMIUM!
Looking forward to seeing more art from you at #devPREMIUM!
Wonderful song,
the title remember me a song of depeche mode!
the title remember me a song of depeche mode!
I had the same song in mind
Hello!! Your beautiful piece of work has been featured!! [link]
Have a wonderful weekend!!
Have a wonderful weekend!!
amazing : )
A lovely place to listen to the silence of nature, beautiful work. Love it
so vast and arid climate, a perfect place for contemplation
I'm enjoying the beauty of silence created in this photo
Nice title (along with everything else).
great work


text:
jt 2011/06/03 07:58:56
Does it have something to do with the physical feature of the person or the whole package?
Top Opinion
☠ Live Free Or Die ☠ 2011/06/03 10:22:30+5The looks are one thing, but a sexy girl has the attitude to back it up; she also has confidence and style and CLASS.. and she is also intelligent, Interesting, and well read/travelled. Well, that's what sexy means to me..
More polls by jt
Sort By
- BJet 2013/08/19 01:09:52Beautiful.
- Dezybaby1353 2012/11/11 03:14:07
- nabil 2011/11/28 06:20:25Miss
- nabil 2011/11/28 06:18:38hiiiiiiiiiiiiiiiiiiiiiiiiiiii...
- Mmnoon Almmnoon 2011/06/20 17:09:50hiiiiiiiiiiiiiiiiiiiiiiiiiiiii
- nabil 2011/06/14 14:54:02hiiiiiiiiiii
- Mmnoon Almmnoon 2011/06/13 17:12:22
- dmac 2011/06/07 07:49:25That means different traits to everyone. But someone that is personable, and confident about themselves and surroundings. At times looks could play a part. If I has to pick a physical trait it would be eyes.
- ernest debrew 2011/06/06 22:02:21Just because a woman is physically attractive, it does not mean that I would automatically fall in love with her.
When it comes to a sexy woman, she must have the qualities I am looking:
smart, not so serious, natural, enjoying life, a little mature, feminine, does not give up
I will give you some examples.
- ernest ... ernest ... 2011/06/06 22:04:29
- ernest ... ernest ... 2011/06/06 22:06:39
- ernest ... ernest ... 2011/06/06 22:08:15 (edited)http://www.movieposter.com/po...
Picture of Shakira.
- meshell ernest ... 2011/06/07 02:22:52yes shakira is
- ernest ... ernest ... 2011/06/06 22:10:16
- Mmnoon ... ernest ... 2011/06/13 17:13:10
- ernest ... ernest ... 2011/06/06 22:10:51
- Emily 2011/06/06 19:55:38A sexy guy...well he does have to have good looks..
and..has to have swagger..look calm and he has to be smart, and a little intriguing...
- Broken 2011/06/06 06:09:29Nothing at all anymore.
- Silver Dew 2011/06/05 00:06:53+1It has nothing to do with physical beauty or the whole package. Everyone is beautiful or sexy, as you put it, in their own way. To me, I consider personality. A person might be good looking on the outside, but the person might be disgusting on the inside. Some of us tend to chose body over soul.
- Ramon 2011/06/04 15:33:22
- carlton999 2011/06/04 03:18:29
- Toots 2011/06/04 02:56:48
- Lerro DeHazel 2011/06/04 02:13:20
- DavidAdams 2011/06/04 02:08:02+1The whole package is what counts, at least once we reach an age where compatibility is key. The one thing that makes me melt, well, two: one's eyes and smile. What is most sexy to me is confidence, a sense of humor, and someone with whom I can converse.
Looks fade, but a great personality is always.
- BobJessen 2011/06/04 00:46:21
- Jackie 2011/06/03 23:33:24
- Jeok 2011/06/03 21:14:55 (edited)+1The Whole Enchilada. Her tortilla should be attractive to me, I don't really give a damn what other's think; relatively femininely shaped and of a healthy physique; be intelligent, not necessarily of any particular educational class, but well-read, interesting, inquisitive, fun-loving and adventurous; have an even disposition, but excited when something tickles her fancy; love children and animals, but not necessarily having to have any of her own, Confident in herself and her choices, always; considerate and kindhearted, but not a total social animal, who is paraticular and picky with whom she associates and has relationships; Worldly, well traveled, physically or by study; have a wide variety of tastes, for example, like Star Wars, Love Story, Imagica, Bones, The Mentalist, The Way We Were, Barbarella, good poety and drama, well-read, physically and sexually and adventurous-not a prude, not arduous, a day and night person, depending upon whom she's with; accommodating, but not slavish, non-judgmental until all the facts are exposed... that's where I begin, but comfortable with herself and having an idea who she is, but willing to travel a path of mutual discovery. And, may I add, that She likes me and my mind, also. IMHO Thank You For Your Indulgence
- Catnip "Guru" ◊◊◊∞◊◊◊ 2011/06/03 21:14:11
- Jareth Majere 2011/06/03 18:35:10
- kresge 2011/06/03 18:30:43+1Actually, it has nothing to do with looks as far as I'm concerned. I've seen drop dead gorgeous men that did nothing for me, and average looking men that were sexy as heck.
Mostly I think its a "presence"....an attitude of self confidence, but short of cockiness, and usually there is some unique feature that attracts me. I thought my ex had a sexy nose ~ go figure!!
- rand 2011/06/03 16:50:37
- Patriot Unit 2011/06/03 16:43:36
- Tiffers 2011/06/03 16:28:29
- Wonder Woman 2011/06/03 15:45:54
- Jersey Roze ♥Jwon's Cyar'ika ♥ 2011/06/03 15:41:49
- Lexandrea 2011/06/03 15:38:55
- Silvery Slash 2011/06/03 15:29:03
- gkirmani 2011/06/03 15:22:41
- wow-really 2011/06/03 15:04:53
See Votes by State
2016/02/11 08:20:00
Hot Questions on SodaHead
More Hot Questions


text:
* Kids & Teens Interactive: Monday, October 29 - Tuesday, October 30, 2001, Los Angeles, California USA.
The Kids & Teens Interactive conference is about developing global interactive youth communities and marketplaces. Currently, kids and teens represent the fastest growing market segments in the areas of Internet usage, cellular phone usage and gaming. The Kids & Teens conference will provide the latest information on Internet and wireless usage, content development, marketing and revenue streams. Participants will gain useful insight from industry leaders regarding how to successfully build, sustain and benefit from the rapidly expanding interactive youth arena. The conference will take place at the Hilton & Towers, Universal City/Los Angeles. For more information, contact: Carol Cooke at Brunico Communications, 366 Adelaide St. West, Toronto, ON, Canada M5V 1R9; Tel: 416) 408-2300 x462; Fax: (416) 408-0870; Email: firstname.lastname@example.com; Web: http://www.kidsandteensinteractive.com


text:
Discover an
appartement a vendre Vidauban
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The VISIUP agency can get a business visa Vietnam for a foreigner.
The Tangka travel agency offers a voyage Vietnam, voyage Thailande, voyage Perou, voyage Canada, voyage usa, voyage Turquie, to discover these beautiful Asia countries.
The French company MBH offers a location voiture avec chauffeur paris to drive towards the vietnam.
The French company Stained Imbert is in the creation vitraux towards the Vietnam.
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Land for sale in Phu My Hung in the district 7 in Ho Chi Min City. This land is adapted to build a wonderful house or villa. The quarter (Phu My Hung) is really beautiful with several green spaces maintained beside nice houses and nice villas.
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Starting a new project ? Contact us !
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text:
Looking to make his mark in the NBA, forward Brandon Davies didn't stay unemployed very long. The rookie free agent was cut by the Los Angeles Clippers last week, then signed with the 76ers on Sunday and participated in his first practice on Monday.
The 6-foot-10, 240-pound Davies, who averaged 17.7 points and 8.0 rebounds this past season for Brigham Young, participated filled out the roster for the Sixers, who open the NBA season Wednesday at the Wells Fargo Center against the Miami Heat.
"I am extremely excited," said Davies, a former teammate of Jimmer Fredette who is third on the BYU career list with 135 games played. "Especially being waived not knowing what would happen and a couple of days later you have a great deal.
Davies earned national attention in March of his sophomore year when he was dismissed from BYU's team after admitting to having premarital sex, which violated the part of BYU's honor code that requires students to live a "chaste and virtuous life."


text:
Ronald J. Latourette, 69Published 11:21pm Wednesday, June 6, 2012
Ronald J. Latourette, 69
Born: April 6, 1943
Died: June 5, 2012
Ronald James Latourette, 69, passed away peacefully on June 5, 2012, surrounded by his family.
He was born in Plainwell on April 6, 1943, to Ralph Owen and Winifred Elizabeth (Pallett), who precede him in death.
Ron grew up in Otsego and was a member of the Boy Scouts, rising to the rank of Eagle Scout.
He graduated from Otsego High School in 1961 and met his wife, Bonnie Jo (Pryor), at the Wesley Foundation on the campus of Western Michigan University. They married on May 20, 1967. They recently celebrated their 45th wedding anniversary with their traditional, shared hot fudge sundae.
In 1970, Ron received a bachelor of arts degree in education from Western Michigan University. He came to Dowagiac and taught mathematics for Dowagiac Union Schools for 25 years before retiring in 1996.
During his career he chaired the Mathematics Department for several years. Ron was also a faculty adviser for the Students Against Driving Drunk chapter, a Ski Club adviser and a chaperone for students on trips to England and France.
In addition to teaching at the high school, he was an adjunct faculty member of Southwestern Michigan College, where he taught technical math for a number of years.
He enjoyed the pottery classes there and became very good at throwing pots on the wheel.
As a member of First United Methodist Church for 42 years, he sang in the choir for more than 20 years, was recognized for his lay speaking ministries and also taught Sunday school.
For many years, he enjoyed the annual guy's day trip to the Indianapolis 500 time trials. A 23-foot fall from a roof Aug. 24, 1994, resulted in transforming his body into a quadriplegic, but it did nothing to dampen his love of life and his positive attitude. Family was extremely important to Ron, and he always was available to help in any way he could.
He was an avid fan of genealogy and keeping in touch with his multitude of friends and family by email.
He also was enthusiastic about creating on his computer unique geometric designs out of flower petals and racing his granddaughters on their bikes with his wheelchair.
He loved the challenge of brain-teaser puzzles and playing cribbage and he enjoyed viewing kites, even when he could no longer fly them. His unique sense of humor kept those around him light-hearted.
Ron is survived by: his wife, Bonnie; two sons, Ryan (Carrie) and Matt; and granddaughters, Anne-Marie and Emma. He also leaves behind: two sisters, Donna (Zaidos) Church and Nancy (Sie) Roe; nieces, Jeannine, Karen, Carol, Emily and Melanie; and nephews, Scott, Peter, Chris, S.T., Steve, Danny and Doug.
He was preceded in death by his mother-in-law, Arlene Pryor, and brother-in-law, Lawrence Pryor.
Visitation with the family is scheduled from 1 to 4 p.m. and 6 to 8 p.m. Friday at Yazel-Clark Funeral Home in Dowagiac. Funeral services will be at 11 a.m. Saturday at First United Methodist Church of Dowagiac with a luncheon immediately following.
A short visitation at the church will be held immediately prior to the funeral at 10 a.m.
Interment will take place at Elmwood Cemetery in Wayland.
The family is requesting that memorial contributions be made to Habitat for Humanity, 601 Sycamore St., Niles, MI 49120; Wesley Foundation of Western Michigan University, 2101 Wilbur Ave., Kalamazoo, MI 49006; Dowagiac Union Schools Ron Latourette Scholarship Fund; or First United Methodist Church of Dowagiac. Please sign his guestbook and leave a message at www.yazel-clark.com


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Yeah yeah I'm slow as all hell. Problem is that I'm getting more and more anal about pages...Although I might have some more free time on my hands with certain projects getting done. Welp. Let's see. Here's to getting back to plot after sexeh time. XD
posted by Puneeco @ 15 Jan 2015 10:58 am - 1 comments


text:
i hate chicks before dicks or bros before hoes, why cant love ever come first?
if you step on a crack, you break yo mamma's back
Best Answer
Jeez ! Google `Cockney rhyming slang` then come back and say one to me lol !!!!
Best Answer
"Live every day like it's your last". Uh, if it were your last day on earth, would you be Facebooking this silliness at work?

"Everything happens for a reason". Or maybe some stuff is just random nonsense.
Best Answer
Bros before Hoes xD it's said, but ironically it's the opposite
Best Answer
"Who does that?" I've always found that one to be. Uh, the person who did it, does it.
Best Answer
"Every month that we do not have an economic recovery package 500 million Americans lose their jobs." Nancy Pelosi.
Best Answer
I just think that they have been said before and fear they will be said again.
Best Answer
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text:
Broadcast from the Stefan Edlis and Gael Neeson Foundation Talk Studio, supporting arts and communications outreach.
Oct. 31, 2011
Al Qaeda has degenerated into a fractured, marginal body that is kept alive largely by the anti-terrorist bureaucracy it helped to spawn, says Fawaz Gerges, a professor at the London School of Economics. He discusses his new book The Rise and Fall of Al-Qaeda. Also, in Pakistan, trucking has become an important part of the country's economic engine. Their colorful trucks, however, look nothing like the ones you see on American highways. The World Vision Report's Jessica Partnow reports from the heart of Karachi's truck decorating business.
Fawaz Gerges talks about 'The Rise and Fall of Al-Qaeda'Oct. 31, 2011
The Pakistani art of truck decorationOct. 31, 2011
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RRS tripod head compatibility to Manfrotto 055CXPRO4
Started Jul 1, 2013 | Discussions thread
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Junior Member • Posts: 30
RRS tripod head compatibility to Manfrotto 055CXPRO4
Jul 1, 2013
Could you tell me which tripod head ( RRS BH-55 or BH-40 ) is compatible with Manfrotto 055CXPRO4 tripod.
As I cant test it and dont want to end up getting the wrong one- too small/ too big.
So anyone using Manfrotto 055CXPRO4 and RRS?
Thank you
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Poke-Apocalypse App || Ash by shotachiiWatch
©2014-2016 shotachii
Name: Ash
Age: 18
Gender: Him/his pronouns
Species: Sylveon
Birthday: November 18
Job: Thief
Weapon: Knife
Nature: Careful
Summary Characteristic: Quick to flee
Ability: Cute charm
Moveset: Moonblast, Hyper voice, Wish, Toxic
History: Ash was quite a loner as a young child and was always wandering around the city by himself. He was terrible at socializing with others and would often freak people out because they thought he was a bit weird, but honestly, he was just really awkward. Ash didn't really know his parents and his parents never took the effort to get to know him either. Because of that, he was never close to his family and they drifted further and further apart from each other. The only gift he'd ever received from his mother and father was a small Teddiursa ragdoll that quickly became his best and only friend. He loved the tiny doll very much and always conversed with it. Ash took great care of it and made sure that it never got dirty. He would also sing to the doll every night before he turned in for the night. The doll's name was Ari and he considered it to be his best friend and he and the doll were never kept away from each other and he'd absolutely refuse to let anyone other than him touch it.
When the apocalypse started and the city was overrun by zombies, he had watched as a Deathwolf zombie ripped his most beloved companion into pieces. Ash couldn't do a thing about it. He was so paralyzed with fear and horror at the sight of his beloved childhood companion being "killed" right in front of him that he was forced to turn away and flee. Since then, he tried to build himself up and tried to grow stronger so that he would actually be able to fight if he is ever met with such a dilemma again. Although he still dislikes fighting and prefers to run away, he is pretty skilled with a blade. He is still somewhat introverted, but he has learned to keep a friend or two because he knows that surviving in a world over-ridden by zombies by himself would be next to impossible. He keeps the chains around his ribbons as a sort of "symbol" to remind him that he is still tied down by his insecurities of never becoming stronger and he uses the mask as a way to keep a sort of "positive" appearance.
Personality: [+] Calm [+] Listener [+] Patient [+] Very attentive [-] Awkward [-] Somewhat selfish [-] Paranoid [-] Nervous
Ash is very calm and patient and it is rather difficult to make him angry. He is a wonderful listener, mainly because he never disturbs the speaker and remains silent most of the time until the other party is finished speaking. He is very quick with his mind and has no trouble analyzing cryptic information. He has a super long attention span and can stay focused for hours, depending on how interested he is. He also pays very close attention to detail and hardly anything escapes his notice. Ash can be rather selfish and likes to keep information, food and weapons to himself. If you reason with him or if he likes you enough, he may let you in on the goods though. Ash is very paranoid and can be rather pessimistic, always expecting the worst and never hoping for the best. A sudden noise can startle him easily and he gets easily scared. Because of this, he appears to be nervous all the time and always glances around his surroundings. It's hard for him to unwind and relax properly and is always alert and on the lookout for any signs of danger. Even though Ash can be kind of quiet at times, he can join in a conversation if someone talks to him first, since he is pretty shy around new people and isn't really the best at starting a conversation. He'll be happy to talk to you if you speak to him first though. Or if you give him a nice little gift. He'll open up to you right away! He also hates conflict and always tries to stay on everyone's good side.
Hobbies: Surprisingly, Ash enjoys singing once he knows that he's completely alone.
Likes and dislikes:
[✓] Singing
[✓] Reading
[✓] Learning
[✓] New weapons
[✓] Dolls
[☓] Noise
[☓] Nosy people
[☓] People who constantly pester him
[☓] Super bright places
[☓] Super dark places
Extra: He's demisexual
Theme song: N/A
Can we rp? :3
Sure! how would you like to rp? Skype, notes, or?
!!!!! wHAT A CUTIE??
Om G LIKE WOWWIE HE'S SO cu te like pfff he's an awkward child???
n ah man more like a rad child
and he likes dolls omf <333
he 's so p re sh
Om G LIKE WOWWIE HE'S SO cu te like pfff he's an awkward child???
n ah man more like a rad child
and he likes dolls omf <333
he 's so p re sh
hhhhhh omigosh thank you ; w ;
yes he's so awkward
just like his creator //shot
Ahhhh thank you for the nice comments /w\
yes he's so awkward
Ahhhh thank you for the nice comments /w\
Woah, look at this guy. Would you like to rp?
Ah hue hue yes thank you ; v ;
And sure! What method do you prefer? c:
And sure! What method do you prefer? c:
i am in love with your style help me
his design is beauty and perfection i----
wow omg quq
welcome to the group, amazing job!
his design is beauty and perfection i----
wow omg quq
welcome to the group, amazing job!
Welcome to the group; I'm always open for rps and I would love to rp with the dude! <3
Right now their is an event going on it the chatroom feel free to join! ;0;
Right now their is an event going on it the chatroom feel free to join! ;0;
Ah thank you ; v ; I'd be happy to rp with you as well! ^ 0 ^
Alrighty! I'm heading over to the chatroom right now u v u
Alrighty! I'm heading over to the chatroom right now u v u
Wow! He's so cool! In the picture he's all like "Yo wut up" But in the bio he's like "...Hello." LOL
Nah I kid,but I love him,he's detailed,he's well though out,he's got a great design and personality!
You did really well making him! Keep it up!
Nah I kid,but I love him,he's detailed,he's well though out,he's got a great design and personality!
You did really well making him! Keep it up!
LOL yeah kind of... I just wanted to fill up the space in the application orz
Ahhhh thank you ; 3 ; I appreciate it! ; v ;
Ahhhh thank you ; 3 ; I appreciate it! ; v ;
i love the design it's so hhhhhhhhhh
i love the design it's so hhhhhhhhhh


text:
September 22, 1965 - November 23, 2013
Billy Allred, age 48, passed away November 23, 2013 at Avera McKennan Hospital in Sioux Falls. Memorial service will begin at 10:00 AM on Tuesday, November 26, 2013 at George Boom Funeral Home in Sioux Falls.
William Albert Allred was born on September 22, 1965 in Rock Rapids, Iowa to William and Deloris (Johnson) Allred. The family would move to George, Iowa where Billy attended school. Following high school, Billy moved to Tulsa, Oklahoma to study Aerodynamics. He moved to Sioux Falls and began working for MCT Truck Wash and most recently, the call center in customer service at Midcontinent Communications.
BIlly enjoyed fishing, the sciences, and was a "Jack of All Trades". He was an artist and was especially skilled in sketching wolves.
Grateful for having shared his life are his daughter, Ashlie Allred; mother, Deloris Allred; sisters, Denese (Mitch) Holland and Debra (Saad Imtobell) Allred all of Sioux Falls; many dear relatives and friends.


text:
This live event has finished
- Heavy wind and rain battered the county yesterday.
- Many roads and public transport remain affected by flooding today.
- River Lugg and River Wye have fallen but more bad weather is expected to hit the county tomorrow.
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