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Are you Hiromichi Kai?Claim your profile
Publications (22)79.96 Total impact
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ABSTRACT: Galectin-9 is a member of the galectin family that has a wide spectrum of biological functions. Among them, galectin-9 has been known mainly as a potent chemoattractant for eosinophils. In addition, galectin-9 alters the T-cell balance by negatively regulating T-helper (Th)1 and Th17 cells, resulting in Th2 polarization. Atopic dermatitis (AD) is a skin allergic disease characterized by peripheral eosinophilia, mast cell activation and predominance of Th2 cells. To investigate possible roles of galectin-9 in AD, we measured serum galectin-9 levels in AD patients and investigated galectin-9 expression in lesional skin by immunohistochemistry. Serum galectin-9 levels in patients with AD were significantly higher than those in healthy controls and correlated with the Eczema Area and Severity Index. Serum galectin-9 levels were decreased after treatment, accompanied by improvement of skin lesions. Immunohistochemical study revealed that galectin-9 was expressed on epidermal keratinocytes and mast cells in lesional skin of AD. Our results suggest that elevated galectin-9 expression is associated with progression of AD and that galectin-9 could be a therapeutic target in AD. © 2015 Japanese Dermatological Association.
Article: Depsipeptide and roxithromycin induce apoptosis of lymphoma cells by blocking extracellular signal-regulated kinase activation[Show abstract] [Hide abstract]
ABSTRACT: Depsipeptide (FK228), a histone deacetylase inhibitor, was recently approved for use in cutaneous T-cell lymphoma. Roxithromycin (RXM) is a macrolide antibiotic that can induce apoptosis of some T-cell lines. In this study, we investigated whether combination of FK228 and RXM had a synergistic inhibitory effect on cell survival of various lymphoma cells and which signaling pathway was affected by the drugs in the presence or absence of chemokines, which were reported to inhibit apoptosis of some tumor cells. FK228 and RXM additively decreased the number of HUT-78, Ki-JK and EL-4 lymphoma cells at doses over 50 nmol/L and 50 μmol/L, respectively. These drugs inhibited phosphorylation of Akt and extracellular signal-regulated kinase (ERK) of EL-4 cells in a dose-dependent manner. Significant association between ERK phosphorylation and cell number or annexin V(+) cells suggested that the ERK pathway may be critical for survival of EL-4 cells. Combination of 10 or 50 nmol/L of FK228 and 10 μmol/L of RXM decreased cell number of HUT78 and EL-4 compared to a single use of each drug. Our in vitro study suggested that combination of FK228 and RXM may be helpful for enhancing tumor killing effects. Although further study is necessary, this combination may be applicable to patients with cutaneous T-cell lymphoma in the future.
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ABSTRACT: Abbreviations: AD, atopic dermatitis; ATX, autotaxin; EASI, Eczema Area and Severity Index; LPA, lysophosphatidic acid; VAS, visual analogue scale
Article: Variations in Serum TARC and I-TAC Levels Reflect Minor Changes in Disease Activity and Pruritus in Atopic Dermatitis[Show abstract] [Hide abstract]
ABSTRACT: Atopic dermatitis (AD) is a chronic or relapsing inflammatory skin disease. Scratching in AD patients results in proinflammatory cytokine and chemokine production. Thus, serum levels of monocyte chemotactic protein-1 (MCP-1), regulated on activation, normal T-cell expressed and secreted (RANTES), macrophage inflammatory protein (MIP)-1 beta, eotaxin, thymus and activation-regulated chemokine (TARC), and macrophage-derived chemokine (MDC) were increased in AD patients, compared with normal controls (1-4). With regards to Th1 chemokines such as interferon (IFN)-gamma-inducible protein 10 (IP-10), IFN-gamma-inducible T-cell alpha-chemoattractant (I-TAC), and monokine induced by IFN-gamma (MIG), their expression in lesional AD skin was confirmed by immunohistochemistry (5). They may negatively contribute to the development of AD because macrophages from AD patients produced lower levels of IP-10 compared to cells from healthy controls in response to a-toxin (6) and the expression of MIG and IP-10 was lower in Langerhans cells from patients with AD than from patients with psoriasis, whereas the opposite was observed for TARC and MDC (7). Visual analogue scale (VAS) is a valuable method to assess pruritus intensity in patients with pruritic dermatoses (8). In this study, we focus on temporal variation of pruritus in each patient and compare serum samples taken at different time points when there were only slight, if any, changes in disease activity. The aim of this study was to highlight the most sensitive chemokine associated with changes in pruritus in AD patients.
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ABSTRACT: Visfatin, a novel adipocytokine, is related with chronic inflammatory diseases, especially those characterized by T helper (Th)1-type immune responses. In this study, we examined serum visfatin levels in patients with atopic dermatitis (AD) or cutaneous T-cell lymphoma (CTCL), both of which are Th2-dominant diseases. Serum visfatin levels in patients with AD or advanced stage CTCL were significantly elevated compared to healthy controls. In CTCL patients, serum visfatin levels significantly decreased after treatment. Serum visfatin levels correlated with eosinophil counts in AD patients, whereas they correlated with the visual analogue scale itch scores and serum C-C motif ligand (CCL) 11 and CCL26 levels in CTCL patients. Visfatin expression by adipose tissue in lesional skin of AD and advanced stage CTCL was enhanced compared to that of healthy controls. These results suggest that visfatin may also be important in the development of Th2-dominant diseases as well as in Th1-type diseases.
Article: Pruritus in atopic dermatitis is positively correlated with serum TARC levels and negatively correlated with serum I-TAC levels
Article: Serum Gastrin-Releasing Peptide Levels Correlate with Pruritus in Patients with Atopic Dermatitis[Show abstract] [Hide abstract]
ABSTRACT: Abbreviations: AD, atopic dermatitis; GRP, gastrin-releasing peptide; GRPR, GRP receptor; PGP, protein gene product; VAS, visual analog scale
Article: Sugaya M, Miyagaki T, Ohmatsu H et al.Association of the numbers of CD163(+) cells in lesional skin and serum levels of soluble CD163 with disease progression of cutaneous T cell lymphoma. J Dermatol Sci 68:45-51[Show abstract] [Hide abstract]
ABSTRACT: Classically activated macrophages produce IL-12, IL-23, and TNF-α, whereas alternatively activated macrophages (M2 cells) produce IL-10 and express several receptors such as mannose receptor and CD163. Tumor-associated macrophages exhibit M2 phenotype, whose presence has been associated with poor prognosis in various tumors. To investigate distribution of CD163(+) cells in lesional skin and serum levels of soluble CD163 (sCD163) in patients with cutaneous T cell lymphoma (CTCL), atopic dermatitis (AD), or psoriasis. The numbers of CD163(+) and CD68(+) cells in lesional skin of CTCL, AD, or psoriasis, and in normal skin were examined by immunohistochemistry. Serum soluble CD163 (sCD163) levels were quantified by enzyme-linked immunosorbent assay. The numbers of CD163(+) cells in lesional skin of CTCL, AD, or psoriasis were significantly larger than in normal skin. In CTCL, the numbers of CD163(+) or CD68(+) cells increased as more tumor cells infiltrated and they decreased after treatment with topical steroid and ultraviolet light. Moreover, CTCL patients with an increased number of CD163(+) cells showed worse prognosis. Serum sCD163 levels in patients with CTCL, AD, or psoriasis were significantly higher than those in normal controls. In CTCL patients, serum sCD163 levels significantly correlated with serum soluble interleukin-2 receptor and CCL17 levels. In AD patients, serum sCD163 levels correlated with serum IgE levels. The numbers of CD163(+) cells in lesional skin and serum sCD163 levels were associated with disease progression of CTCL. Further study focusing on CD163(+) cells in CTCL lesional skin would be an interesting research field.
Article: Analysis of serum chemokine levels in patients with HIV-associated eosinophilic folliculitis[Show abstract] [Hide abstract]
ABSTRACT: Background Patients with human immunodeficiency virus (HIV) infection exhibit various skin diseases. HIV-associated eosinophilic folliculitis (EF) and pruritic papular eruption (PPE) are frequently seen. Objective To understand the mechanisms underlying HIV-associated EF and PPE. Methods In order to know frequencies of EF and PPE among patients with HIV infection, we first collected HIV+ patients who visited dermatology clinic in National Center for Global Health and Medicine during February 2007. We next collected 25 serum samples from HIV+ patients with skin diseases from May 2008 to May 2010. Eight of 25 patients had EF (EF group), four had PPE (PPE group) and others had non-itchy skin problems such as condyloma acuminatum (no itch group). Results We first confirmed high frequencies of EF (10.7%) and PPE (5.3%) among 75 HIV+ patients who visited our clinic during one month. We then measured serum levels of CCL11, CCL17, CCL26 and CCL27. Serum CCL17 levels in EF were significantly higher than those of PPE and no itch group. Serum CCL26 and CCL27 levels in EF were higher than those of no itch group. The number of CD4+ cells in EF was significantly lower than that in no itch group. Conclusion High serum levels of CCL17, CCL26 and CCL27, and low CD4+ cell counts may account for the development of HIV-associated EF.
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ABSTRACT: Abstract is missing (Letter).
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ABSTRACT: Dermatofibroma, also called cutaneous fibrous histiocytoma or sclerosing hemangioma, is a fairly common, benign cutaneous tumor. Polypoid dermatofibroma is an unusual and poorly recognized form of this entity. We describe a peculiar case of this variant presenting with a unique morphology characterized by a round flat shape with a slim pedicle, although its histopathological picture was rather typical of that of ordinary dermatofibroma.
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ABSTRACT: Abbreviations: BP, bullous pemphigoid; CCL, CC chemokine ligand; CCR, CC chemokine receptor
Article: High levels of LIGHT and low levels of soluble herpesvirus entry mediator in sera of patients with atopic dermatitis
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ABSTRACT: C-C chemokine receptor (CCR)10 is a specific receptor for chemokine ligand (CCL)27, a selective chemoattractant for skin-associated memory T cells to cutaneous sites. In melanoma, CCR10 increases the ability of neoplastic cells to grow, invade tissues, disseminate to lymph nodes, and escape the host immune responses. In this study, we investigated the expression of CCR10 and its ligand CCL27 in squamous cell carcinoma (SCC). CCR10 and CCL27 were expressed in SCC, actinic keratosis (AK), Bowen's disease, and seborrheic keratosis (predominantly prickle cell type), but not in seborrheic keratosis (predominantly basal cell type) and basal cell carcinoma. Furthermore, CCR10 and CCL27 were overexpressed in SCC relative to Bowen's disease, an early stage of SCC. Consistently, a human SCC cell line, A253 cells, and HaCaT cells exhibited CCL27 production that was strongly induced by tumor necrosis factor-α and interleukin-1β. Finally, A253 cells expressed stronger intracellular CCR10 compared to HaCaT cells by flow cytometry. These results suggest that CCR10 and CCL27 overexpression in SCC is related to the progression of SCC and is useful for the diagnosis of SCC.
Article: α4β7 Integrin is essential for contact hypersensitivity by regulating migration of T cells to skin[Show abstract] [Hide abstract]
ABSTRACT: β7 Integrin, a cell adhesion molecule, is present in the form of α4β7 integrin or αEβ7 integrin. α4β7 Integrin is expressed on most leucocytes and is essential for their migration to gut-associated lymphoid tissues by interacting with its primary ligand, mucosal addressin cell adhesion molecule-1, which is preferentially expressed in gut-associated lymphoid tissues. Although the importance of α4β7 integrin in intestinal inflammation has been established, its role in cutaneous inflammation remains to be elucidated. We sought to investigate the role of β7 integrin in cutaneous inflammation. We used a murine contact hypersensitivity model and examined the role of β7 integrin by using β7 integrin-deficient and αE integrin-deficient mice. β7 Integrin-deficient mice, not αE integrin-deficient mice, are defective in contact hypersensitivity responses. β7 Integrin deficiency does not affect irritant contact dermatitis. The distribution, migration, and function of antigen presenting cells from β7 integrin-deficient mice are comparable to those from wild-type mice. Moreover, sensitized β7 integrin-deficient T cells are able to respond to antigen stimuli in vitro and elicit contact hypersensitivity responses when directly injected into the skin. However, they are defective in reaching the skin under inflammatory conditions, resulting in reduced contact hypersensitivity responses when intravenously injected. Furthermore, intraperitoneal injection of anti-α4β7 integrin neutralizing antibody elicit impaired contact hypersensitivity responses. α4β7 Integrin contributes to contact hypersensitivity responses by regulating T-cell migration to inflammatory skin.
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ABSTRACT: The immunological significance of IL-27 has been reported and discussed in various Th1/Th17-mediated inflammatory diseases. However, its importance in psoriasis is unknown. We investigated pathophysiological roles of IL-27 in psoriasis in this study. Serum IL-27 levels in psoriatic patients were significantly higher than those in healthy controls, and correlated with disease severity and serum IFN-gamma levels. An immunohistochemical analysis revealed the infiltration of IL-27-secreting cells in the papillary dermis of psoriatic skin lesions but not in skin lesions with atopic dermatitis or normal skin. Furthermore, IL-27 alone greatly induced in vitro CXCL9, CXCL10, and CXCL11 production and tyrosine phosphorylation of signal transducer and activator of transcription 1 in normal human keratinocytes, while it suppressed the tumor necrosis factor-alpha-induced production of IL-1alpha and CCL20. These results indicate that IL-27 may promote the onset of psoriasis, while it may simultaneously attenuate the expanded inflammation in this disease. Our results implicate potential therapeutic effects of IL-27 for psoriasis.
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ABSTRACT: Proteus syndrome is a complex and highly variable disorder comprising malformations and overgrowth of multiple tissues. We present a 65-year-old Japanese man who had multiple spinal meningiomas and accompanying neural symptoms. His right leg showed hypertrophy with cerebriform connective-tissue naevus on the sole, and macrodactyly. Chest computed tomography imaging revealed mild cystic and emphysematous lung changes, which were possibly related to Proteus syndrome. Otherwise, he had no particular cutaneous, musculoskeletal or visceral involvements. Because of the rather insignificant clinical features, he had not been accurately diagnosed in the past and yet had survived to this age. In particular, the presence of spinal meningiomas as an exceptional complication was sufficiently confusing to consider that he had neurofibromatosis. Doctors should be familiar with the diverse clinical pictures of this rare syndrome for its correct diagnosis and proper management.
Article: Extensive skin pigmentation caused by deposits of metallic particles following total elbow arthroplasty: Metallosis or not? [21][Show abstract] [Hide abstract]
ABSTRACT: No abstract is available for this article.
Top Journals
The University of Tokyo
Tōkyō, Japan
- Department of Surgical Sciences
Sagamihara National HospitalЙокосука, Kanagawa, Japan


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Join the 'Tamiflu' group to help and get support from people like you.
Tamiflu Questions
We found 54 questions associated with the 'Tamiflu' topic.
How long does it take for Tamiflu to work? My husband was diagnosed by our family doctor (tested?
... and confirmed) to have the flu on Wednesday (I had a flu shot, he didn't). Thursday I started getting symptoms (today I feel TERRIBLE) but called our family doctor right away and started ...
Posted 27 Jan 2012 • 1 answer
Tamiflu - Can I take tamilflu and Tylenol cold & flu severe around same time?
My throat is sore and took Tylenol cold & flu severe for pain, sore throat, headache, cough. Then found tamilflu
Posted 4 Sep 2015 • 1 answer
Can Tamiflu and Ibuprofen be taken at the same time?
Posted 18 Jan 2015 • 1 answer
Can my child take benadryl and tamiflu togther?
Posted 15 Jan 2014 • 1 answer
Anyone else have terrible negative side effects with the use of Tamiflu?
16 year old daughter diagnosed with Influenza, so her MD prescribed Tamiflu for her, 75mg. Capsules, twice daily for 5 days. He also prescribed my husband and myself Tamiflu, 75 mg. Capsules, once ...
Posted 8 Dec 2014 • 3 answers
What pain reliever can be taken with Tamiflu?
Posted 14 Jan 2015 • 1 answer
Tamiflu meds?
I was prescribed tamiflu, but i have been sick for 4 days already. everything i have states that it must be started within 48 hours of symptoms. ... what happens if its been longer than 48 hours? Is ...
Posted 17 Mar 2015 • 1 answer
Tamiflu - My 6yo son came out positive for Influenza A on friday and its monday and he still has?
... high fevers?
Posted 8 Dec 2014 • 1 answer
Tamiflu and yellow, foamy diarriah? Help!?
My 17 yr old son has taken this for three days. He had the diarriah to begin with but now it is yellow and foamy. Thinking of stopping this med. Any help out there?
Posted 23 Mar 2015 • 1 answer
Zithromax - Does z pack treat sinusitis ?
I was treated for flu type A with tamiflu , then doc put me on zpack for bronchitis. Last four to five days had to take sumatriptan for migrane which takes care of pain but last night it felt like my ...
Posted 29 Dec 2014 • 2 answers
My 12yr old daughter is taking tamiflu for 5 days now, canshe take anihistamine for nose congestion?
she is sneezing ALOT, no coughing but congestion in head and nose.
Posted 3 Jan 2015 • 1 answer
Can I give my son Qtapp while he's taking Tamiflu? He's 12 years old 81lbs?
He has the flu
Posted 5 Mar 2015 • 0 answers
Tamiflu - Anyone told to take a longer course?
My daughter is 3 yo and developed a fever a week ago. We went to her pediatrician and she tested positive for Influenza A. She was prescribed Tamiflu and thus treatment was started less than hours ...
Posted 21 Dec 2014 • 1 answer
Tamiflu - I am pregnant of 28weeks and I have been told to take the medicine what side effect will?
... make to my baby
Posted 12 Feb 2015 • 1 answer
I'm taking tamiflu and my nose is stopped up I been taking for 3 days, anything is can take or do?
Posted 1 Jan 2015 • 1 answer
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Events for
- February13
5th Annual 5K Run/Walk for Chocolate | 10:00am
From 02/13/2016 To 02/13/2016
Join us for the 5th Annual 5K Run/Walk for Chocolate as we celebrate Sunriver Resort's Month of Chocolate. Hot chocolate, coffee and other delights await you at the finish line. Sunriver Resort will donate $1,000 of the proceeds to the Bethlehem Inn in Bend, Oregon.
Register at http://www.sunriver-resort.com/chocolate
Regular Registration | $40, shirt not included | Closes February 12th
Race Day Registration | $45, shirt not included | February 13th
Packet and shirt pick-up is available in the Vandevert Room at the Lodge on February 12th from 4pm-6pm and February 13th from 8:30am-9:30am for Race Day Registration.
No race admittance after 9:30am on February 13th.


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- 107Promote
Canvas Print
Midnight Noirby Mark Giarrusso
Fine art print on bright white, fine poly-cotton blend, matte canvas using latest generation Epson archival inks. Individually trimmed and hand stretched museum wrap over 1-1/2" deep wood stretcher bars. Includes wall hanging hardware.
Nice! Where is this Mark? Chicago?
Thanks Maite! It's New York.
Very nice!
Thanks Lisa!
Beautiful shot Mark!!
great great great!!
this is so great, Mark!
nice depth and light!
Thanks everyone!!
Love :)
AWESOME PIECE MARK! Very cool looking!
Thanks so much everyone!
Love the Batman-ish atmosphere!!!
haha... thanks MoArt!
Love your city scapes!
Way too cool! :)
Thanks Joy and Shutter!
This is truly a great one!
Nice Mark!
Thanks Thomas and Biff!!!
Nice geometic lines in this one!
Thanks B!!
beautiful ;)
yay! I'm number 100 promoting!
superb!!!! ♥
Thanks Mariana! Too bad you can't really see it!! LOL
Thanks Carina! xoxoxox
Hey, it's an amazing piece, even though you can't see it = Cheers!
It's like the Emporers New Clothes!! YAY!!! Cheers!!
Thanks Michael!
Thanks Gale!
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Archived Story
Missing woman found safePublished 10:57am Monday, September 16, 2013
Tallapoosa County Sheriff's Department investigators said Friday that a missing Dadeville woman has been located and is safe.
Dana F. Barlow disappeared Wednesday after leaving her Dadeville area home for a job interview. She was located by law enforcement in another state based on information obtained by TCSD investigators.
"We have found her safe and have been in contact with her," said Tallapoosa County Sheriff Jimmy Abbett. "There was no foul play or criminal activity whatsoever."
Abbett declined to give further details about Barlow's condition or whereabouts.
Barlow's friend Stephanie Andrews said she was found in Orange County, Fla., near Orlando. Barlow is suffering from "some type of amnesia," Andrews said, though doctors "can't pinpoint exactly what it is at the moment." Barlow is with her sister, Andrews said.
The family is "trying to keep it low-key" beyond that, Andrews added. The effort now, she added, is to get Scott Barlow to Florida to check on her.
"Ultimately the best thing is to know that she's alive and breathing," Andrews said. "That's a blessing."


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Article Summary
The European Space Agency (ESA) this week announced the first two missions selected for its Cosmic Vision 2015-2025 Plan. The first, known as Solar Orbiter, will see a spacecraft operating closer to the Sun than any previous mission with a particular focus on examining the solar wind. The second, Euclid, is essentially a space telescope whose primary goal is to study the accelerating expansion of the universe in an attempt to provide an understanding of the exact nature of dark matter.
Read the full article: European Space Agency selects first two "Cosmic Vision" missions
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114 Airbus, 100 Boeing: Iran on a shopping spree?
114 Airbus, 100 Boeing: Iran on a shopping spree?January 25, 2016 12:46
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Dubai builder Arabtec surges after $545 mln contract award
MIDEAST STOCKS-UAE mixed, Qatar falls in early trade
MIDEAST STOCKS-Markets face further declines after global markets slump
Abu Dhabi's Gulf Capital raises $175 mln for second credit fund
MIDEAST STOCKS-Gulf hit by oil, global equities slide, regional fears
Dubai stock index drops 3 per cent in early trade
Qatar recalls envoy to Iran after attacks on Saudi missions
PRECIOUS-Gold hits 7-week high as worries over China hurt stocks
MIDEAST STOCKS-Emaar drags down Dubai; Gulf markets weak
Saudi Q3 GDP growth edges down to 3.6 pct y/y
Executive chairman of Dubai Multi Commodities Centre, Ahmed bin Sulayem, explains why embracing change is pertinent to growth
February 17, 2014 10:32 by kippreport
Four years ago, former CEO of Dubai Multi Commodities Centre (DMCC), Malcolm Wall Morris, said: "Unless we change the way we do business, we change the culture of business, we drive the growth of our businesses, we are all going to have to go home and we shall return what money we have left to His Highness Sheikh Mohammed bin Rashid Al Maktoum, Vice-President and Prime Minister of the UAE and Ruler of Dubai, because we are not worthy of fulfilling his vision to make Dubai a centre of the trade of commodities."
The DMCC embraced this challenge and turned it into an opportunity. Four years later, we are now the largest and fastest-growing free zone in the region. We also sit, globally, in the top three for the trade of gold, diamonds and tea. Who would have thought that, from four years ago, when we were almost bankrupt with less than 3,000 member companies, we would reach to where we are today. What we have collectively achieved in four years is that we have trebled the size of the DMCC's business by adding an average of 200 companies and approximately 1,500 visas every month – an incredible achievement. We have been focused on attracting new businesses to the DMCC and Dubai, but, looking forward, we have set a very ambitious target of building the world's tallest commercial tower – The Burj 2020 – that needs to be delivered in six years from now, which will create room for another 8,000 companies and 30,000 to 40,000 employees. So, again, we are effectively going to double the business by 2020.
The difference today when compared with four years ago, however, is that we are now the largest and fastest-growing free zone in the UAE with no rivals, so why change? We're already number one, so why change? Tough question, perhaps, but the answer is simple, if we don't change and create a culture of an organisation that can double itself in the next six years, we will no longer be number one – we may not even exist. It's a big task and it's different from last time, but it's essential.
However, what is central to that change is that we know where and how we can improve. We realised that we are good at attracting customers, but not so good at retaining and enhancing those businesses. We looked at the Royal Decree, signed by His Highness Sheikh Mohammed (then Crown Prince of Dubai) in 2002 for the creation of the DMCC, and realised that our role in Dubai is to make as much impact on its economy as we can – ie on its GDP and FDI. We believe that doubling our business will make a significant impression on the economy, however, to achieve this, we have to focus on our customers to ensure they can succeed and grow.
This is what we call our 'Attract, Retain, Enhance' strategy, which will help us to make an impact on Dubai's GDP. So, what better way of signalling this change, this new direction, new culture and growth than a rebranding exercise?
It is something that we all relate to practically and signifies that, from this day forward, we are no longer just going to attract businesses, we are going retain and enhance them. How can a new logo and a set of new brand guidelines achieve that? It is clarity in communication that will increase efficiency, for both our customers and us.
We are removing the confusion around what we are. We are the DMCC, not Jumeirah Lake Towers (JLT). As of today, we are located in the DMCC Free Zone and not the JLT Free Zone. It's all about one brand, focus, clarity and efficiency.
Four years ago, we, at the DMCC, agreed that the only way to succeed is to embrace change and the way we do business, the culture of our business, and to continuously innovate and drive growth – these are the only ways in which we can retain our position as number one in the region, and to continue to lead and grow on a global scale.
Mea region to display world's fastest mobile data traffic growth
February 16 2014
Saudi Arabia to invest SAR30.9 billion in tourism between 2013 and 2023
February 17 2014


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Lionel Messi has every reason to smile
/ Sport
Lionel Messi strengthened his claim to be seen as the greatest footballer of all time by winning a record-breaking fourth consecutive Fifa Ballon d'Or.
The 25-year-old took the honour ahead of Barcelona team-mate Andres Iniesta and Real Madrid striker Cristiano Ronaldo.
The Argentina forward enjoyed a remarkable 2012 even by his own high standards, most notably surpassing Gerd Muller's 40-year-old record of 85 goals in a calendar year, finishing with an incredible 91.
Messi, wearing a polka-dotted dinner jacket and matching bow tie, said: "To tell you the truth this is really quite unbelievable. The fourth award that I have had is just too great for words. I would like to recognise my other colleagues from Barcelona."
Messi polled 41.60% of the votes, with former Manchester United ace Ronaldo taking 23.68% and Iniesta 10.91%.
Although he missed out on both the Primera Division and Champions League crowns, Messi racked up a host of personal achievements last year.
He scored an unprecedented 50 goals in a La Liga season, a record 14 goals in a Champions League season and became the first player to net five times in a Champions League match.
He also shattered the myth that he does not perform as well for Argentina as he does for his club by scoring 12 goals for his country in nine games.
Messi's fourth award took him past the three Fifa gongs won by former Brazil striker Ronaldo and ex-France midfielder Zinedine Zidane.
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Speech is silver; and silence is golden very rightly said. But have you ever realised that being too nice and too caring to others can lead to depression. 547 more words
Tags » Egoistic
credit (nahh..not the bank kinda credit)
while volunteering today at my local charity shop, me and another staff convinced one of the customers to take gift aid, this means that we get more from the things that they are giving. 392 more words
Question: Formerly, plastic surgery was available only to Hollywood stars. But these days it is popular among ordinary people who want to look younger and more beautiful. 378 more words
An Open Letter to the Filipino Guys
How do you actually describe the Filipino guy? Dubbed as Mr. Maginoo but medyo bastos by DJ Alvaro's iconic song in the 90s. The sons have fully embodied the familiar lyric with how Filipino guys act today. 772 more words
Kyohei Rikudoh Review
Sexy, Egoistic
PERVERT persona of REVANCE
Kyohei Rikudoh is the producer and the sexy persona of the boy group called Revance, which I actually thought it was Reverance not, Revance. 2,595 more words
In with the new, out with the old
Happy New Year! Yup, 2015 has finally reached us (It might be the other way around). On the eve of crossing to the awaited new year, I was up until two am texting my best friend. 213 more words


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My Monday column unskews the Unskewed Polls website and how Republicans are desperate for polls that match their fictitious view of the president.
Last week, when the conservative British commentator Stuart Varney said on Fox News Channel that every poll, including the Fox News poll presumably, doesn't "feel right" and dismissed the "mathematical gobbledegook" used to ascertain the respective results, it all made sense to me.
Conservatives are liars. To themselves more than anyone else.
The conservative self-deception has fooled many of them into believing the president is less popular than he is, that Mitt Romney is more electable than he is, and that the economy is worse than it really is. Rewind through the last four years and recall the syllabus of non-reality-based attacks on the president. He'll destroy the nation. He's a secret Muslim. He's lazy and shiftless. He's a socialist. He's a Nazi. He's somehow a Nazi-communist-socialist. He's the only politician who uses Teleprompters. He's solely responsible for the national debt, which somehow didn't exist prior to January 20, 2009. He's pushed "failed economic policies" "down the throats" of the American people. He's responsible for the biggest tax increase in the universe. He gutted welfare reform. He stole from Medicare. He's an unpopular, idiot "man-child" lightweight failure who's apologizing for America and bribing poor black people with free Obama Phones.
None of that is true, except to conservatives who, above race and every other nearsighted justification for their anti-Obama apoplexy, are simply terrified that center-left policies might actually work. Continue reading here.


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If Obama's biggest asset is his inexperience, then if by the slightest chance he were elected and were to run for a second term, he will have to claim he didn't learn anything the first four years.
There was also this inspirational nugget: "Each and every time, a new generation has risen up and done what's needed to be done. Today we are called once more, and it is time for our generation to answer that call." Is this guy running for president or trying to get people to switch to a new long-distance provider?
He said that "we learned to disagree without being disagreeable." (There goes Howard Dean's endorsement.) This was an improvement on the first draft, which read, "It's nice to be important, but it's more important to be nice."
This guy's like the ANWR of trite political aphorisms. There's no telling exactly how many he's sitting on, but it could be in the billions.
Obama's famed eloquence reminds me of a book of platitudes I read about once called "Life Lessons." The book contained such inspiring thoughts as:
"When was the last time you really looked at the sea? Or smelled the morning? Touched a baby's hair? Really tasted and enjoyed food? Walked barefoot in the grass? Looked in the blue sky?" (When was the last time you fantasized about dismembering the authors of a book of platitudes?)
I can't wait for Obama's inaugural address when he reveals that he loves long walks in the rain, sunsets, and fresh-baked cookies shaped like puppies.
The guy I feel sorry for is Harold Ford. The former representative from Tennessee is also black, a Democrat, about the same age as Obama, and is every bit as attractive. The difference is, when he talks, you don't fantasize about plunging knitting needles into your ears to stop the gusher of meaningless platitudes.
Ford ran as a Democrat in Republican Tennessee and almost won -- and the press didn't knock out his opponent for him by unsealing sealed divorce records, as it did for B. Hussein Obama. Yet no one ever talks about Ford as the second coming of Cary Grant and Albert Einstein.
Maybe liberals aren't secret racists expunging vast stores of white guilt by hyperventilating over B. Hussein Obama. Maybe they're just running out of greeting card inscriptions.
Rush Limbaugh defends Rubio's debate answer: He's absolutely right that Obama knows what he's doing | Allahpundit
Time for Team Hillary to break out the gender card for young liberal women who prefer Sanders | Allahpundit


text:
In this video Dan finishes off the electrical in the house and shows how to install switches, light fixtures, and the breaker box.
If you are already a subscriber, you can log in here. Otherwise, go to our eCourse page to join.
Subscribe to our mailing list for free! We promise not to share or sell your email


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Graduate Programs
Authentic leadership has never been more important. Stetson's graduate programs are designed to connect professional ability with critical soft skills, the foundation for effective leadership and greater career success.
It's about defining success on your terms. We are committed to an education that allows you to do just that - reach your full career potential while holding true to a healthy work-life balance.
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Get more information about graduate, professional and certificate programs. We'll provide the details you need to make the right decisions for your future.
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The Career and Professional Development Office provides an array of resources and services to help further student and alumni success.
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Interested in Jinjiang?
We'll send you updates with the latest deals, reviews and articles for Jinjiang each week.
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Up one level: Fujian


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Janine and her associates steal from the Paynes; Calvin trains for a marathon.
CJ learns he may have another daughter; Malik begins hanging out with the wrong crowd.
Calvin plans a house party when the rest of the family visits relatives in Florida.
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text:
Many Democrats are coming around to the reality of the situation, and are standing up for poor and minority students. Politico reports that many high-profile Democrats have broken with the party on education reform agenda items such as charter schools, standardized testing, and teacher evaluation and accountability.
This follows work at the grassroots level from groups like Democrats for Education Reform and The Education Trust, two non-profits which have for years calling for reform to close the achievement gap between white and minority students, and rightly pointed to teacher union obstructionism as a prime reason so many efforts at public education reform have, until recently, gotten nowhere.
Even President Obama supports charters and accountability. His Education Secretary Arne Duncan supported the ruling. "Millions of young people in America … are disadvantaged by laws, practices and systems that fail to identify and support our best teachers and match them with our neediest students," Duncan said, calling the ruling "a mandate to fix these problems."
Rules that protect bad teachers from firing are common across the country, not just in California. According to New York's school boards association, the average proceeding to remove even one incompetent teacher extends for 830 days and costs taxpayers $313,000. So teachers are far more likely to be moved to failing schools than fired. And these schools tend to be filled with black and Latino kids. The problem entrenches itself as those teachers stay in the system longer, where they are then protected by seniority. Not only does this keep a failing teacher in the classroom, but it makes it impossible for schools to hire new, more effective teachers.
The suit was filed by a group called Students Matter, made up of a group of 9 student plaintiffs, and backed by a Silicon Valley millionaire. They are considering similar lawsuits in Connecticut, New Jersey, New Mexico, New York, Oregon and elsewhere.
Opposition to teacher tenure is as commonplace as it is common sense. But legislative reform has been nigh-on impossible, thanks to pressure from teachers unions on lawmakers to maintain their legal protections. It's no surprise, then, that reform has required the courts to get involved.
However, striking down hiring and firing laws will likely improve California's public education system by flushing out poor-quality teachers and making room for better ones. This will likely energize Democratic families frustrated by failing schools to demand action from their legislators. Then lawmakers will have to choose: Help struggling families get the same quality public education as their better-off peers, or continue protecting teachers unions from competition and accountability? It's an uneviable position, born from a disgusting history of pandering to and prioritizing labor at the expense of society's most vulnerable. Let's hope they do the right thing.
Bush mocks Rubio and his fans: Stop whining that it's "unfair" that you're being attacked by another candidate's Super PAC | Allahpundit


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Answers / JavaScript
I have a pdf that contains hyperlinks to other website. This pdf itself is available as a link on a website. When this pdf is loaded in IE window, and user clicks on any of the links inside this PDF, the link opens in the same window. I want all the links to open in a new window.I have tried different softwares to publish the pdf (MS Word, Open Office, Bull PDF, online services), but the links inside the pdf always open in the same window
Yatish Ram 1499 days ago
Create a button field or link and in the Action tab, select Run a JavaScript from the Select Action pull-down menu. Click the Add button to open the JavaScript Editor and type the following code in the Editor window:
app.launchURL("http://www.mycompany.com/pdfDocument.pdf", true);
In the above code, replace www.mycompany.com with your URL. Replace pdfDocument.pdf with the name of the PDF you want to open. The "true" statement triggers opening the PDF in a new browser window. ;-)
I don not want to open another pdf from inside pdf. All I want is to open the web links inside pdf in new browser window. At the moment all links inside pdf open in the same window.
Yatish Ram Commented 1493 days ago | Report
i follow the above steps but it shows alert "Not Supported Javascript Action". is there any other way to open the hyperlinks in PDF to new window.
Pralhad Patil Commented 1339 days ago | Report
I have this setup in place to open a new PDF from within an existing PDF and it works perfectly...except when you try to view from Firefox (v19). In Firefox it says an error occurred on opening the first PDF although it does open and then the second link does not do anything. Any suggestions?
Shembi Nagel Commented 1034 days ago | Report
It worked for me in IE with that solution, but not for firefix nor Chrome. Anyone managed to make it work for these browser?
Vincent Hamel Commented 897 days ago | Report
Acrobat has this option built into it. Go to Edit>Preferences>Internet. In the Web Browser Option section, deselect Display PDF in browser.
Making this change will result in a security alert for links opening outside the PDF, but you'll get this warning only once for each external site. You'll need to click the box Remember this action for this site for all PDF documents, then click "Allow" to OK the security of the external site.
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text:
DMV.com is a privately-owned website and is not affiliated with government agencies.
DMV.com provides a comprehensive Bill of Sale Package that includes:
When you purchase a DMV.com Bill of Sale Package you will gain instant access that will allow you to download it immediately. We will also send you an email record of the sale that links back to your documents. Once you have purchased the document you can download and print it as many times as you like.


text:
Thermopro is a privately held company based in metropolitan Atlanta. Founded in 1976, the company evolved from industrial storage products to producing a high qMore
$5 mil. - $10 mil.in Revenue
20 - 50EmployeesContact people at this company
thermoforming solutionsMore
Plastic, Packaging & ContainersManufacturingMore
1600 Distribution Drive Ste DDuluthGeorgia30097United Statesview map
(678) 475-1647(678) 475-1747Fax
ProPub_Iteration_NoTests.312[01] SEIDXWK-7


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'); } -->
WELL DRILLING/EXCAVATION: PRECISION PAVING CO. New Driveways, Asphalt Maint., Sealcoating & Road grading. FREE estimate. CA. Lic. #864063 (559)877-PAVEMore info Email a friend
LAWN/GARDEN/LANDSCAPING/TREES: *KELLY'S* YARD CLEAN-UP ONE CALL DOES IT ALL 30 + years experience in: Weedeating, Spraying. Brush clearing-burning-chipping. Berry bush & poison oak removal. Seasonal yard cleanup. Roofs & gutters cleaned. Honest, dependable, quality work. Senior discounts...More info Email a friend
HOME & BUSINESS IMPROVEMENT: DON'T MOVE IMPROVE! K&E Construction All phases of construction No job too small - Since 1975 CA. Lic #307444 (559)287-5528More info Email a friend
HOME & BUSINESS IMPROVEMENT: D.E. HARTESVELDT CONSTRUCTION General Contractor Improving homes for over 25 years. Specializing in: Kitchen and bath remodels, Room additions, decks, repairs and appliance installations. CA Lic. #475909 (559)760-4976More info Email a friend
WELL DRILLING/EXCAVATION: P.W. LIKE Construction Driveway & finish grading, Firebreaks. Disc, mowing, post hole drilling, concrete. CA Lic. #619812. Call Phil (559)283-6951More info Email a friend
LAWN/GARDEN/LANDSCAPING/TREES: TIP TOP TREE SERVICE Your Complete Tree Service SENIOR DISCOUNT Licensed, Bonded, Insured. Richard Clark Owner/Operator CA Lic. #756532 (559)683-6081 or (559) 683-1746 We go out on a limb for youMore info Email a friend
WELL DRILLING/EXCAVATION: FISK EXCAVATING Driveway & Pad grading, rock drilling & blasting, demolition, gravel & fill dirt hauling. Underground utilities, septic systems. CA Lic.#707745, Insured, 25-yrs. exp. Gen. Eng. Contractor. (559) 642-6868More info Email a friend
LAWN/GARDEN/LANDSCAPING/TREES: GARDENING - PLANTING, Pruning, sprinklers, retaining walls, yard clean-up, weedeating, wood splitting & more. Non CA Lic. Free est., (559)642-2462More info Email a friend
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MISC. SERVICES: MOUNTAIN POOL Care. Professional service, repair & installation. Monthly, one-time clean-ups & start-ups. Call, 559-760-5559.More info Email a friend
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text:
Events - 28 Jul 14
Military MondaysMonday July 28th 2014
Active Duty Military Personnel receive FREE admission Mondays in July.
Military family members and Retired/Veterans receive HALF OFF admission with military ID.
Dates: July 7, 14, 21, 28
Read More
The Smurfs!Monday July 28th 2014
10am, 1pm, 2:30pm, 4:30pm
Read More
Extreme Raptors Bird ShowMonday July 28th 2014
12pm, 3pm, 6pm
Read More


text:
Powling, Chris.
Powling, Chris, 1943-
VIAF ID: 59119287 (Personal)
Permalink: http://viaf.org/viaf/59119287
Preferred Forms
- 100 1 _ ‡a Powling, Chris
- 100 1 _ ‡a Powling, Chris
- 100 1 _ ‡a Powling, Chris (undifferentiated) (sparse)
- 100 1 _ ‡a Powling, Chris
- 100 1 _ ‡a Powling, Chris
- 100 1 _ ‡a Powling, Chris
4xx's: Alternate Name Forms (2)
- 400 1 _ ‡a Powling, Chris
- 400 1 _ ‡a ポーリング, クリス
|Are you ready for Oxford reds?
|Authorgraph no. 44: Anthony Browne
|Authorgraph no. 45: Dick King-Smith
|Authorgraph no. 57: Roger McGough
|Authorgraph No. 59: Astrid Lindgren
|Authorgraph no. 65 : Naomi Lewis
|Authorgraph No. 84 : Geoffrey Trease
|Authorgraph no. 96 : Philippe Dupasquier
|Best of Books for keeps : highlights from the leading children's book magazine
|The big friendly giant...
|Books that do furnish a war
|A centenary review march 1980-september 1996
|Children's book prizes 1999-2000
|Daredevils or scaredycats, 1979
|Dāru san tte donna hito
|East of the Sun, West of the Moon
|Emil '87
|The Emil Award
|Faith farewell
|Fiction for the filofax : warning: the slavish following of lists can damage your reading
|Finding out who I am : Robert Cormier in conversation with Chris Powling
|Flinthjärta, 2010:
|Forever William
|Ghost behind the stars
|A guide to poetry 0 - 13
|Happy birthday to us...
|Harrin seikkailupäivä
|Harrin unelmaloma
|Harrin uusi koti
|Harry heeft vlekjes
|Harry moves house
|Harry on holiday
|Harry the superhero
|Harry with spots on
|Harry's party
|Have yourself a very creepy Christmas
|Hiccup Harry
|How to... start storytelling
|Introducing Michael Hague
|Jakten på storfifflarna
|The jolly postman: another Ahlberg classic.
|The Kingfisher book of scary stories
|Kit's castle
|Le Lav'auto fantôme / Chris Powling, 1989
|'Leave the talking to us'
|Long John Santa
|Maigret to Miffy
|Making words memorable : Chris Powling pays tribute to Michael Rosen
|The man behind 'The man' : Raymond Briggs talks about his latest book to Chris Powling
|Martin in Wallywood
|May we recommend 'The eleventh hour' of Graeme Base
|The mother Goose Award
|Multi-million pound mascot
|On the ghost trail
|Patricia Crampton wins the 1999 Marsh Award
|Phantom carwash
|Przyjęcie u Henryczka
|Rekku koulussa
|Rekku on mestari
|Rekun syntymäpäivä
|Roald Dahl
|Rover goes to school
|Rover the champion
|Rover's birthday
|Sendak's schoolbook : Maurice Sendak talks to Chris Powling about 'I saw Esau : the schoolchild's pocket book', which he describes as 'a major movement in my life'
|Shirley Hughes
|Special outsiders
|Super-Henryczek / tekst Chris Powling ; il. Scoular Anderson ; przekł. Anna Błasiak. - Wrocław, 2000.
|Supermies Harri
|Supershorts : seriously spooky stories
|Talking books
|The tempest
|Treasure at the flea market
|What makes Walker run?
|Where readers rule... Barrington Stoke
|The white spaces on the map : Chris Powling talks to Francois Place about his new Travel-cum-Fantasy-cum-Picturebook
|Ziggy et l'ogre des glaces
Countries of Publication (9)
Publication Statistics
Selected Publishers (11)
Personal Information
- xxk -


text:
This year there's been a lot of people representing the French-speaking Mozilla community at the JDLL in Lyon, France — 18 persons IIRC!
There were booth for XUL fr, FrenchMoz, Geckozone, FrenchBirds and for Mozilla Europe, Mozilla Women… as well as KompoZer, of course.
I've had the opportunity to give a talk on KompoZer 0.8, in front of more people than I expected for a relative small event. I could present the work I've been doing on KompoZer for the last twelve months and give a mini-roadmap about the future of this project.


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MOONNIGHT by kingryuuzakiWatch
©2013-2016 kingryuuzaki
Rated ^^/*
It looks very beautiful .___.
love your art always, but this is one of the best pics from you i have seen in the last time! love it all, from colours to topic, very awesome! <22
ooohh my.. the artwork is beautiful, it is so really nice
This gives off a strong Doll effect, did you use an actual doll as a reference for this?
So very wonderful


text:
Change Location
ACE Fit Share
Add these shoulder exercises into your regular workout routine and increase your upper body strength, while strengthening and stabilizing your shoulders. From the stability ball dumbbell press to the medicine ball push-up, these exercises are a great way to strengthen your deltoids, rotator cuff and trapezius muscles. Browse through our large collection of detailed tutorials and step-by-step demonstrations from today's leaders in the health fitness industry. For full workout routines featuring these shoulder exercises, visit our Workouts section.
Fit Life Articles
Extra weight around the midsection can carry with it a number of risk factors for certain diseases. Fight back with the right foods to help you lose the weight and get the flat belly you desire.
As the demands of daily life pile up, it's easy to find yourself exhausted, defeated and overwhelmed. Fortunately, just because you lost it temporarily doesn't mean you can't find it again. Here is a three-day guide for getting yourself get back on track with the way of...
If you're like many people, a lack of sunlight during the long, cold months of winter can leave you feeling unmotivated and blue. While the warm, long summer days are still months away, there are still plenty of things you can do right now to boost your energy, mood and...


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PCI Cards
Display Items Per Page
Add an eSATA port to a desktop computer through a PCI Express slot. This eSATA Controller Card turns a PCI Express (1x) slot into an external SATA port, to provide a quick and hassle-free external storage solution. Supporting SATA 300 (SATA II) hard drives (backward compatible with SATA /150) and d… [More]
This 4 Port PCI IEEE 1394 FireWire 400 Adapter Card turns a motherboard PCI slot into four IEEE 1394a FireWire 6-pin female ports (1 internal, 3 external) - a cost-effective solution that lets you connect any FireWire 400 device that uses a 6-pin connector to your desktop computer. The card can be i… [More]
This PCI based SATA Controller Card allows you to turn a PCI slot into one internal SATA and one external SATA (eSATA) connection. Supporting SATA 150 hard drives, and data transfer rates of up to 1.5Gbps, this controller card is the perfect solution if you need an extra SATA port or want to externa… [More]
AddOn's industry-standard NIC (Network Interface Card) provides direct PC connectivity to high speed Fiber Optic and Copper media networks. On board the NIC is either: (a) one or more open transceiver slots or (b) one or more embedded transceivers (Ethernet, Fiber Channel or SONET/SDH). Both the o… [More]
SIIG's eSATA II PCIe i/e controller card is designed to add two SATA channels (one internal and one external) for connecting up to two additional SATA hard disk drives. The eSATA II PCIe i/e controller card features the latest eSATA connector, delivers data transfer rates of up to 3.0Gb/s, and suppo… [More]
This 2 Port PCI Express Internal Serial ATA Controller Card adds two internal SATA II (SATA /300) ports to a computer through simple installation into an available x1 PCI Express slot. Supporting data transfer speeds of up to 3.0 Gbps, the SATA controller card features Native Command Queuing support… [More]
The PEXSAT32 2-Port PCI Express SATA 6 Gbps (SATA 3.0) Controller Card offers simple connectivity between a host computer and SATA 3.0 devices - a cost-effective solution for connecting high-speed storage, such as High RPM Hard Drives and Solid State Drives (SSD), which in turn allows for easier dat… [More]
The PEXESAT32 2 Port PCI Express eSATA 6Gbps Controller Card offers simple connectivity between a host computer and eSATA 3.0 devices - a cost-effective solution for connecting high-speed storage, such as High RPM Hard Drives and Solid State Drives (SSD), which in turn allows for easier data backups… [More]
Add external and internal 6 Gbps SATA 3.0 ports for high speed storage access The PEXSAT31E1 2-Port PCI Express SATA/eSATA 6 Gbps (SATA 3.0) Controller Card adds one internal SATA 3.0 (6 Gbps) and one external eSATA 3.0 (6 Gbps) port, through a single PCIe slot. Providing simple connectivity between… [More]
You are viewing page 1 of 2


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Brand new books only please!
We receive almost all our book donations in mint condition from UK publishers. This fantastic support comes mainly in the form of overstocks and returns, as well as office copies or occasionally, special print runs.
If you represent a publisher or bookseller please have a look at our publisher book donation pages where you can find out more about donating books to us.
What about second-hand books?
The new book donations we receive more than fulfil the quotas we can ship overseas. This means we cannot accept second-hand books from individuals, companies, organisations or schools.
However, there are other organisations which may be able to accept your books:
Book Harvest who resell selected educational texts and make a donation to us for each text sold. Find out more.
Better World Books sell second-hand books and donate a percentage of their profit to Book Aid International. Find out more.
Book Aid Charitable Trust send new and second-hand Christian books to areas of need. Find out more.
If you have already collected second-books and would like to support us, why not try holding a book sale in your local community? Invite friends, family and neighbours, price the books simply and provide tea and cake. You could even ask guests to bring along more books to sell. For more information on holding a book sale, visit our fundraising pages here.
If you have any questions, please email Simon Mercer, or telephone on 020 7733 3577.


text:
Follow me on: - www.facebook.com/mirellasantan…
All ther rest was painted!
All my artworks are copyrighted © Mirella Santana 2009-2013
Respect my gear and not distribute unless you have my permission otherwise be infringed my rights by law.
~ ♥ ~
incredible, i lke so much
Your beautiful work is featured on my page
Wow!! This is fantastic!
Wow this is definitely up my road of interests :3 It's dark, sombre and just beautiful
Good luck for the contest!!
~Being deeply learned and skilled, being well trained and using well spoken words; This is good luck.
Stunning! Good luck in the contest!
Fantastic Work!
This Picture Seem Like Mother Nature By DanishKuHaikal
Beautiful!. Amazing job! ...
Very great artwork !
Well done!
wow so amazing
Lovely my dear!!!
Awesome PM - Your Attention To Detail Is What Makes This A Great Piece Of Art.
Thats awesome
gentle manip, well done
this is simply amazing. Whoa.
I am in love with this
I am in love with this
You went so far in your skills & ideas.. I want to do one thing for you .


text:
We have recently (3 Nov 2013) returned from spending two glorious weeks at The Ledra Beach Hotel. Last year we visited with our family to celebrate our Golden Wedding Anniversary. Once again we had a great experience. Indeed there are aspects of the holiday, introduced by the Management, that have greatly enhanced the experience. These relate mainly to service and choice in the Dining Room. It was nice to be served wine and other drinks by the staff, rather than serving yourself. Small thing, but much appreciated.
The Entertainment team was hard working and provided a good, well balanced, progamme of activities and events to keep people amused/active.
I rate this hotel and all members of staff as top-class, and look forward to returning to The Ledra Beach next year.
- Official Description (provided by the hotel):
- The Louis Ledra Beach Hotel is situated on the Paphos beachfront overlooking the beautiful Mediterranean sea. Treat yourself to the premier setting of our hotel (20 minutes walk from Paphos fishing harbor). Only steps from major historic attractions, shops and entertainment, our Family hotel let you easily explore the entire Paphos area and all the beauties it has to offer. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Travelocity, Booking.com, Expedia, Priceline, Odigeo, Venere, Hotwire and Hotels.com so you can book your Louis Ledra Beach reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Louis Ledra Beach Hotel Paphos
- Iberostar Hotel Paphos
- Iberostar Hotel Ledra Beach


text:
Anyone tried Letrozole / Femara during IVF? Advice please.(1 Post)
Shellster52 Wed 20-Nov-13 02:27:59
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Martina McBride, Sara Evans Cover Dolly Parton's 'Jolene' [Watch]
Martina McBride and Sara Evans recently teamed up for a stellar version of Dolly Parton's classic country song, "Jolene."
Martina McBride and Sara Evans recently teamed up for a stellar version of Dolly Parton's classic country song, "Jolene."
Although it's a little early, Sara Evans is in the holiday spirit! And she hopes that jolly attitude will rub off on her fans when she releases her new holiday album, 'At Christmas.'
From helping with the crops to getting on her horse to wrangle in the cattle, Sara Evans really lived the rural life.
A much more confident Sara Evans emerges on the 11 songs that make up 'Slow Me Down,' her new studio album. From top to bottom this project is a blast of energy. Even the ballads pop with new life an exuberance.
You likely know by now that Sara Evans made a surprise appearance at our Denim & Diamonds St. Jude fundraiser last Friday night. Here's the video! Jaclyn and I had a ball teasing the crowd with our little secret surprise and they absolutely went nuts when they realized Sara was there. WATCH!
Sara Evans is coming to Owensboro to help open our new Convention Center! Her appearance was announced at a press conference held downtown yesterday. She will be the headliner of a big dinner January 31. Wow, the Owensboro Symphony Orchestra Second Street band, painter Aaron Kizer and the Jimmy Church Band will also perform. The 169,000 square foot center will be open to the public for free tours on Saturday, Feb. 1. The Willis clan will perform a free show, too. Giant TV screens will show the UK game Saturday and then Sunday night some big game will be played and shown on the screens as well. 2,000 tickets for Sara's show and dinner will be $100! Various non-profits around town will sell them. Details to come. Now more about Sara ...
After seeing the hilarious behind-the-scenes footage for Sara Evans' 'Slow Me Down' video, the full music video has been release. And in a complete turnaround, viewers won't be laughing; the video is serious and emotional, showing the angst that happens during a breakup.
I am not going to lie. When I heard that Sara Evans was taking on P!nk's power ballad "Just Give Me a Reason" on her concert tour, I was very skeptical. I love me some P!nk and I actually got to see her perform it live at Bridgestone Arena and it was, as expected, AMAZING! P!nk is the bomb and I absolutely love that song. I love it so much and am such a slave to the original, I just wasn't letting myself be convinced that Sara was going to pull it off. But then I saw this...
Danica Patrick starred with Miranda Lambert and now NASCAR driver Carl Edwards takes time to be featured as Sara Evans' love interest in the video for her hit song, "Slow Me Down".
He does a pretty good job of acting. He arrives on the scene about 1:30 into the film. According to Taste of Country, in this exclusive behind-the-scenes clip, it's a breakup song, so there's no hot and heavy between the two, only animated arguing. Watch it all unfold ...
No question was off limits when Sara Evans signed on to do a Reddit Ask Me Anything, where she answered unfiltered questions from fans and users. The singer -- who just released her new single 'Slow Me Down' to iTunes Tuesday (Sept. 3) -- was upfront about her new album, touring plans, morning routine and much more.
Friday, Nashville Kat spilled the beans . . . or rather . . . the corn . . . about Sara Evans' new casserole recipe. As you'll recall, it was about a month ago that she raved about Sara's tomato pie recipe. That particular creation sounded amazing and it was. I made it. A bunch of you made it. And everyone LOVED it. So, now . . . thanks to Taste of Country . . . we have a new Sara recipe to try. Ladies and gents, how does corn casserole sound? That's what I thought! Lol! If you want the recipe, we've got it!
Nashville Kat told Chad and me about this incredible recipe she found from Sara Evans. Woo dogies, easy to make and quick to bake. If you try it let us know...


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We offer indoor air quality improvement through green technologies like ActivePure. We offer ionized water systems and a laundry purification technology for the home.
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We offer green cleaning services in Duluth GA
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We use only green cleaning detergents and eco-friendly products to ensure a healthy environment to our clients in Sandy Springs GA.
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The Tri-County Rural Health Network will be enrolling eligible participants in the Affordable Health Care Act during the month of October at the Holman Heritage Community Center.
Interested participants may visit the Dr. Emma K. Rhodes Education Center located in Classroom 2-3 on the following days:
• 5-7 p.m. Tuesday, Oct. 8;
• 10 a.m. to 2 p.m. Thursday, Oct. 10;
• 5-7 p.m. Tuesday, Oct. 22; and
• 10 a.m. to 2 p.m. Thursday, Oct. 24.
The Holman Heritage Community Center is located at 605 N. Buerkle St. in Stuttgart. For more information, contact Shatoria "Toy" Collier at (870) 659-8768 or Constance Franklin at (870) 209-6806.
Location, ST | website.com


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This is almost similar question to this one: -
I read that thread, and have some more issues, and not sure of how to elegantly build timezone support in PHP/MySQL application.
I am writing an application in PHP, where users can select their timezone.
Here, all timestamps are stored in GMT in MySQL. And I am converting the timezone back to users timezone, when presenting the data.
Now these are the problems I am facing: -
1) I show the user, a list of timezones populated from MySQL's timezone tables, it is a HUGE list and is difficult to chose from.
So, I want to implement something like windows time zone list. Offset with region info.
2) The PHP and MySQL may have different set of list.
3) Where should I convert timezones, in PHP or in MySQL? I have combination of coding. Sometimes it is easy to select a column converted from MySQL, sometimes it is easy to convert in PHP. So, here the previous point becomes very important. For example, in MySQL's time_zone tables Asia/Kolkata, and Asia/Calcutta both were there, but in PHP 5.2.6's default timezonedb, only Asia/Calcutta is present.


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Devil rises by Gait44Watch
©2012-2016 Gait44
Jin Kazama to Devil Jin...
Really incredible
Pure awesomeness. You did a really great job on this
Please do more Jin art
Please do more Jin art
Awesome! O.O
well..... that's not scary that's sexy
OMG!!! This is PERFECT!!! I love THIS!! I love Jin!!


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The largely overlooked resident fungal community plays a critical role in human health and disease.
Owl Be Darned
December 4, 2015|
Researchers studying city-dwelling birds are learning about which animals are more suited to urban life.
December 4, 2015|
Researchers studying city-dwelling birds are learning about which animals are more suited to urban life.
April 4, 2014|
The professor of molecular biology and biochemistry at Simon Fraser University is also an accomplished painter.
January 1, 2014|
Some of the fantastical marine life depicted in a rare, 18th-century book
December 1, 2013|
December 2013's Scientist to Watch is also an accomplished painter.
November 1, 2013|
Surprising trends reveal themselves in this year's Salary Survey statistics.
November 1, 2013|
The neuron-inspired art of erstwhile neuroscientist Greg Dunn
June 1, 2013|
Take a closer look at some of the statistics generated by The Scientist's Best Place to Work Industry 2013 survey.
June 1, 2013|
Scientists working in developing nations who engage in capacity building find it bolsters the lives of locals and their own work.
June 1, 2013|
Yale University evolutionary biologist Steven Brady studies the evolutionary impacts of roads on the amphibians.
April 2, 2013|
Intrepid Norwegian explorers discovered the Antarctic icefish, a marvel of evolution, while venturing to an island at the bottom of the Earth in 1927.


text: I loved "The Omega Man", a classic, now Will Smith stars in a modern version. good effects, good plot, and a twist at the end. so good i had to watch it twice at the theatres (second time with a date, which she clung to my arm during the shocking parts). i was glad that the night creatures didnt talk and had that cult like montage like in Omega man, but legend had a sence of loneliness, which made me a bit sad for Smith's character. But, over all a blockbuster in its own.


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Take Care of Your Ears: Facts About Hearing Loss
The chirping of birds, the joyous laughter of loved ones and the rustling of leaves are all sounds that help shape our world.
"Our sense of hearing is extremely important," says Debbie Abel, an audiologist with the American Academy of Audiology. "It allows us to maintain communication with family and friends, keeps us safe in our environment and on top of our game at work."
But life's noises are either muffled or silenced for an estimated 36 million people in the U.S.
"There's no shame in hearing loss," Abel says. "The shame is doing nothing about it."
To find a specialist, talk to your primary care provider or search the audiology, ear/nose/throat care or otolaryngology categories on AngiesList.com.
Types of hearing loss
CONDUCTIVE HEARING LOSS occurs when sound waves aren't transmitted properly from the outer to the middle ear. Common causes are inflammation caused by colds, allergies and ear infections; the presence of a foreign body or built-up earwax in the ear canal; a perforated eardrum; or fluid in the ear.
"To hear, the three little bones in your middle ear must move freely," Abel says. "If there's fluid, it affects your ability to interpret sound." If you suffer from this kind of loss, Abel adds, you can most likely regain your hearing through treatments with medicine or surgery.
SENSORINEURAL HEARING LOSS occurs when the cochlea of the inner ear, or the nerve pathways to the brain, are damaged. Diseases and viruses — such as Lyme disease and herpes — as well as certain drugs can cause this hearing loss.
"Some medications, like antibiotics with the suffix -mycin or -micin, can damage the hair cells in the cochlea," Abel says. "Unfortunately, this kind of damage is permanent."
Humans are born with 30,000 hair cells per ear. They convert the sound vibrations that travel from the middle ear into electrical impulses that are carried to the auditory nerve.
Abel adds that other possible culprits of sensorineural hearing loss are noise exposure, head trauma and aging.
MIXED HEARING LOSS is a combination of both conductive and sensorineural — is the third kind of hearing loss.
Don't play it by ear
Follow these tips to prevent noise-induced hearing loss:
• If you're exposed to loud noise like a lawnmower or hair dryer on a daily basis, wear protective earplugs or muffs for protection.
• Turn down the iTunes. Abel says you know the volume on your MP3 player is too high if someone next to you can hear your music. "Follow the 60/60 rule for headphones," she says. "Don't listen at more than 60 percent of the maximum volume longer than 60 minutes."
• Silence is golden. Give your ears a break by alternating quiet activities with louder ones.
• Rock on responsibly. Abel says at 110 decibels or more, music concerts of any genre can be damaging. "Wear comfortable earplugs to avoid doing harm."
hearing aid alternatives
My dad is also a WWII vet. He is also from the generation that doesn't want help unless he earned it. But he does take help from the VA now that he's in his 90's. They treat him very well and with respect, which is something his other coverages don't always do. So I am grateful to the VA for that. My question is, he is fitted with hearing aids that go behind his ear. Those are extremely uncomfortable as he has glasses and oxygen tank tubes that go behind his ear so he foregoes the hearing aids. Does anyone know of another style that he could use, that doesn't use the space behind the ear? That would be comfortable for him?
I was involved in this topic re: Hearing Aide service from the VA, as above but had heard nothing further, I am now getting bits and pieces again so would like to broaden the scope to include tinnitus or noises in the ear. I have seen Audiologists and ENT doctors about this for some 25 years. Was advised to join the American Tinnitus Association and was a member for many years and received their rather non-professional Journal for many years. In the past I had rather minor noise in my left ear, static like sounds, that after some testing were attributed to to much fluid in my inner ear. Nine months ago I had 3-way By-pass surgery and a valve replacement and shortly thereafter began to hear major pulsating noises. It was as if a truck was about to drive through the wall of my house. Terrible. Two audiologists said that it was due to my heart. However, I was advised to see an ENT doctor rather than my cardiologist, which I did.I had ssomekind of "plunger" and am scheduled for an MRI tests of my Inner Ear and am scheduled for an MRI.In the past the ENT doctor would evaluate the tinnitus by X-raying my head. The current ENT doctor says that shows nothing and was a waste. Can anyone else shed some light on noise in the ear, as above and efforts to help moderate it? I have taken Ginkgo Biloba for many years for the moderate noise and feel it has been of some help but this new noise drives me up the wall. Many thanks....
The person who is visiting an audiologist should be aware of what is available. So many times people are fitted with those tiny CIC (completely in the canal) hearing aids that end up in the draw because they cannot hear on the phone with them or in a noisy restaurant or airplane. Some, not all hearing aid health providers fit these unsuspecting individuals with these tiny, most expensive hearing aids and because most people who are losing their hearing are led to believe these with help them. I am not an audiologist and I do not fit people with hearing aids. I am a retired microbiologist and know people who have the worst fittings imaginable by so call people who tell them these hearing aids will work. Many people do not ask for a trial period of at least 30 days and when it comes time to return them it does not happen. Instead the hearing health provider cops an attitude. One out of three seniors over the age of 65 has a hearing loss. Hearing loss is an invisible disability and there are 36 million in the USA with a hearing loss. Some seniors are diagnosed with dementia and Alzheimer because they cannot hear well. Many people stay home away from social activities and family gatherings because they were not fitted properly with the correct hearing aid. One size hearing aid does not fit all. Are you a hearing aid dealer? I know Florida has put some these shysters out of business.
Hermine- To quote you "The best hearing aid for you is the one that you hear conversations with. A hearing aid should be behind-the-ear, directional microphones, manual volume control, and telecoils to help you hear on the phone and using assistive listening devices. It should also have WDRC (wide dynamic range compression) program that makes loud sounds softer and soft sounds louder." Those are your words. You cannot make a statement like that. You will lose credibility and the other statements that you make which are good will lose credibility.
Please do not put words in my mouth. Of course a person who realizes they have a hearing loss should see a doctor but not a family physician because some treat hearing loss as not a serious matter because it is not a life threatening illness. First see an otolaryngologist or otologist and then be sure you see a university trained audiologist for an accurate audiogram. A good place to start is a university with a audiology dept or hospital if you do not know where to go. Another excellent organization is Hearing Loss Association of America www.hearingloss.org. If you are experiencing sudden hearing loss see an ear doctor within 72 hours.
Great info and great questions, but no unbiased person to answer, so here are some short answers, if you want more info, email me personally.
Lynn- No hearing stimulus package. Scam to get you in the office.
VA- Great place to get help if you qualify!
Rebecca Y- You can't treat your hearing like you do your toilet paper purchase. My grandmother always told me you get what you pay for. Saving a few dollars today doesn't amount to much if it doesn't do what you want. Go to a doctor of audiology, you won't have to compare test results.
Stanley- See an ENT. If there is a problem, they will tell you your options.
Fred- Great idea, not many people want to admit the have a hearing loss, but really great idea.
Roger- Not sure what information you are trying to give. Hearing loss is not that simple. Distortion can happen in the cochlea (inner ear) and most often the brain (lack of proper practice) The auditory nerve is a conductor, damage happens from atrophy mainly. See a doctor of audiology. It took us 4 years post graduate work to figure out what you are improperly explaining. Stretched ligament? Really?
Hermine-One size does not fit all, your information is not for everyone. How can you make those recommendations without a hearing test and knowing a person's listening needs. Anyone who recommends specific solutions for unknown needs and problems scares me.
DRR- most insurances do not cover hearing aids. If reimbursement continues to decrease at this rate, nobody with any education will test your hearing and the payment for these services are horrible and getting worse.
Beverley- A dysfunctional eustachian tube is when the "pressure valve" that equalizes pressure behind your ear drum is not working properly (clogged) and can create hearing loss, pressure behind the ears, fluid and infections. Can be caused by many things such as a cold or congestion and may occur naturally as we age. See your ENT.
Hope this answers some of your unanswered questions and misinformation.
This is a great representation why people don't get the help they need. So much misinformation and uninformed experts giving advice. See an Academy Certified audiologist. Its a new certification to help consumers/patients find a true expert.
I'll answer any questions you may have email@example.com.
Has anyone had experience with Audibel Hearing in Seminole, FL and the 2.8 Million dollar hearing stimulus package announced for Florida? ($1,000 voucher)
Thanks Walter. My father is one of "the greatest generation", and his focus has always been on what he can do for his country, not what his country can do for him. So I will tell him that he has already "paid" for the hearing aid with his service in the South Pacific in WWII. Happy Veterans Day to you and the veterans of all our wars.
As long as your father served in the US Military, he is entitled to services of the VA. He paid for these services by his service to his country and shouldn't have any qualms about seeking assistance there. He must go to a local VA Center with proof of his military service, such as his Service #, Discharge papers, etc. He will be issued a membership card with his picture on it and he can use any VA center in the USA with it. He will fill out a means form when he applies and once a year, thereafter. As I indicated certain things like Hearing Aides and audiological testing and fitting of aides and batteries for them are FREE. Other things to assist with mobility like canes, lazy-susan like seats for cars, etc. are also provided at no cost. I have no idea how such things are provided free and not others, but only know, through personal experience that they are. Wish your father a "Happy Veteran's Day"
Thanks Walter for the information about the VA. I will do some more checking for my father. He has not used the medical services of the VA and does not want anything that he has not earned. However, since the hearing aids are so expensive, it would be great if he is eligible.
Re: the question by Laurie about the VA's coverage of paying for aides. I am a Vet. and also have to many assets so must make some payments for being seen at the VA. I am on my second set of aides provided at no cost by the VA. They also provide free batteries. Tests by Audiologists are also at no cost as are adjustments to aides.
The best hearing aid for you is the one that you hear conversations with. A hearing aid should be behind-the-ear, directional microphones, manual volume control, and telecoils to help you hear on the phone and using assistive listening devices. It should also have WDRC (wide dynamic range compression) program that makes loud sounds softer and soft sounds louder. When some tells you it is digital ask they to tell you what programs you have. For the first tie I would get a good audiogram in either a university with an audiology dept. or a hospital with an audiology dept. Too many hearing aid deals promise you excellent hearing but when you get home you are disappointed. Be sure to get a 39 day trial basis and during that time go to the noisy restaurant and then go back to have it adjusted while you are on the trial basis. Join www.hearingloss.org for more information and join a local chapter. Hearing loss is an invisible disability.
What is a dysfunctional eustacian tube?
Great to know about Costco - need one as I recently had a sudden total hearing loss in one ear. ENT said to wait for 3 months to see if any would come back - so now need hearing aid.
My ears feel constantly like they are plugged with water. It gets so bad it sounds like a blackbird squawking. I have post nasal drip 24-7 in which I think is the root of my problem, and I mentioned it to my doctor and he said that there isn't much that they can do for me. what is your opinion?
Good article & pics. But first advice is to have your primary Doc check out the problem-you may be referred to an ENT specialist. Then, if the Dr says there's no Medical issue which may be causing the problem, take advantage of all the different companies which provide free tests-but don't buy until you have at least 2 test results to compare the accuracy of the tests. Their equipment or the technician who does the testing(the licensed audiologist doesn't usually do the test itself,(usually just reads the results and then recommends the type aid needed and fits it. After you have at least 2 comparative test results that are either the same or very close, you can shop for the aid. I went through this process and actually the last test perdormed was at Costco Hearing Center.Itw as the most detailed, complete and the audiologist performed the test and we talked about my needs before she recommended I come back when I had thought about it more. Costco sells different brands and Consumer reports rates them as better than most of the big Name brands. Costco prices are usually 50% of the price you'd pay elsewhere. They also have all the follow up services, batteries,cleaning if needed, etc. after you buy, and a guarantee that is terrific.
I would like to see someone develop a small lapel pin, with a logo that would let people know that I am hearing impaired. Many handicapping conditions are immediately evident, but hearing loss isn't one of them! Thanks! :-)
Get evaluated by an audiologist. You can't make decisions about getting hearing aids or about adjusting them until you know whether you have a hearing loss; and if you do, the type, degree, configuration, and symmetry must be determined. If something can be treated medically or surgically, the audiologist will refer you appropriately. If medical treatment is not indicated, the audiologist can advise you regarding the hearing aid options available, costs and so forth. Don't first seek help from a commercial hearing aid dealer or fitter first, because they're in business to sell hearing aids. Get an objective audiologic opinion first.
My father is a WWII vet with a hearing loss. The local VA told him that although he is retired, he had too much income to be eligible for them to pay for the hearing aid.
Where can I check out the VA policies on this?
My hearing aids were covered by my insurance. Look around for another company. I believe the new Affordable Insurance Act says you cannot be refused coverage.
If hearing comes difficult, get a hearing test from an audiologist. A good article for people to be aware what to do if there is sign of hearing loss
Does anyone have a recommendation for the best hearing aids?
Good information. I've had hearing loss for 40 years and have used hearing aids successfully to allow me to live a normal life. It is too bad insurance does not cover them as being hearing impaired leads to isolation, to which elders are particularly exposed.
The article left out three things that may be important. First, the auditory nerve may be damaged. This limits the ability to understand speech. There is no known remedy and the hearing loss is permanent. If you hear a constant hissing noise, a damaged auditory nerve may be the reason. Second, the ligament between the inner-ear bones may be stretched. This problem may progressively attenuate higher-frequency sound. Third, people with hearing aids should know that hearing damage occurs with the sum of the decibel input of the source and whatever is amplified by the hearing aid. Some hearing aids are better than others.
THANK YOU ! very informative.
I liked everything about this story. The text and picture were informative.
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1. It's important that I find a good one
2. I'm not an expert enough to know myself who is a good one
3. The industry is full of advertisements and misinformation
4. I wish I knew what experiences other people have had
That's very difficult to answer without seeing the house. As one poster said, the prep is the most important part. On newer homes that don't have a lot of peeling paint, the prep can be very minimal even as low as a couple or a few hundred dollars for the prep labor.
On a 100 year old home with 12 coats of peeling paint on it, then the prep costs can be very high and can easily exceed 50% of the job's labor cost.
A 2100 sq ft two story home could easily cost $1000 just for the labor to prep for the paint job. That number could climb too. Throw in lots of caullking or window glazing, and you could be talking a couple or a few hundred dollars more for labor.
Painting that home with one coat of paint and a different color on the trim could run roughly $1000 or more just for labor. Add a second coat and that could cost close to another $1000 for labor.
For paint, you may need 20 gallons of paint. You can pay from $30-$70 for a gallon of good quality exterior paint. The manufacturer of the paint should be specified in any painting contract. Otherwise, the contractor could bid at a Sherwin-Williams $60 per gallon paint and then paint the house with $35 Valspar and pocket the difference. $25 dollars per gallon times 20 gallons? That's a pretty penny too.
That was the long answer to your question. The short answer is $2000 to $4000 and up, depending upon the amount of prep, the number of coats, the amount of trim, and the paint used.


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Recipe by: itsnotgracie
Original recipe yields 8 servings
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Watch a professional bartender make a fragrant cucumber vodka cocktail.
Watch a professional bartender make a refreshing vodka cocktail.
See how to make a refreshing vodka, cucumber, and lime juice cocktail.
Very Good! Ratio of vodka to triple sec to lime juice works well.
best shots ever!!
Never tire of these shots..... Perfect ratio of ingredients!!