text: TabsDescription SMS as it should be by Fix Your Funnel Video of The New Rules of SMS (Infusionsoft Edition) Video of Sending Outbound SMS with Infusionsoft Campaign Builder Video of InfusionSoft Plugin: SMS: 1st Incoming SMS of a Conversation Video of InfusionSoft Plugin: Instant SMS Notification Battle_of_the_apps_FYF_Messenger How Fix Your Funnel Text Messaging Works Available in US, Canada, UK & Australia! Send and receive SMS Text Messages with Infusionsoft using the most advanced features and highest rated service available in the marketplace. Capture leads, build rapport & stay in contact with prospects & customers' mobile phones. Before now, mobile marketing was severely limited. You could only send a single text in response to a single incoming text message. This caused people using mobile marketing to settle for less than effective marketing strategies. We've changed the rules of mobile marketing. . . forever. Try it now: In the US Text SMS to (760) 621-8477 Try it now: In Canada Text SMS to (438) 500-1776 Try it now: In the UK Text SMS to 0116 347 0777 Try it now: In Australia Text SMS to 40936 6881 data & msg rates may apply. CHECK OUT OUR OTHER SOLUTIONS: * Integrated Dialer * SendOutCards Integration * Funnel Bots * One Click Up Sell Solution Write a Review Recent Reviews Felix William United States 1/22/2016 1 The support from Fix Your Funnel is a bad joke. I suscribed for the sms service but they didnt helped me to configure the service with my app, instead they asked for money. Belive me this is the worst experince i had ( i use a lot of apps from this Marketplace ) I also asked for a refund 22 days ago and didnt recive anything ( i asked for a fefund when i realized that after 1 day of "service" ) Maybe in the feature will hire moore responsable support people. Reply Neil Schneider United States 12/22/2015 5 Love this app. The staff has been helpful getting me started. The set up was easy and this is a GREAT add on for Infusionsoft. Keep up the great work! Reply Torrey Fingal United States 10/28/2015 5 FixYourFunnel is EXCELLENT!!! It is the missing link for us to really take InfusionSoft to the next level. I would highly recommend this for anyone interested in taking their customer service and satisfaction higher. Reply Read all Reviews Features Features NEW! Live SMS Chat SMS for Infusionsoft first! Live SMS Chat with your own business phone number tracked back into Infusionsoft and distributed between team members in web based app or iOS app! Add text messaging as a communication channel for Infusionsoft and discover why the top business owners are using Fix Your Funnel SMS in their business. Multi-Step, Automated, SMS Conversations You're no longer limited to just one text message. Now you can capture leads with ease using multi step conversations. Combine multiple conversations and keywords to automate lead capture, contact information updating and more with a few simple clicks. Your prospects stay engaged due to the speed of interaction! Automate processes that were impossible in the past! (Watch the video to learn how to get a copy of our Free Report, 21 Mobile Marketing Methods) Unlimited Keywords OK, maybe not unlimited, you can only create as many keywords as you can think of…I'm sure at some point you'd use up all the possible useful combinations of numbers and letters, but with over 750,000 words in the English language at your disposal, I think you'll never have to worry about running out of keywords with Fix Your Funnel! Track-able Links in SMS Add fully trackable links that will apply a tag to the contact that clicks on a particular link in a SMS conversation or outbound SMS message. Use that tag to kick off a sequence or score the lead! Use REAL Phone Numbers, Not Confusing Short Codes Short codes are confusing to most cell phone users. It's a fact. How do I know? I've tested with my own money (watch the video above to hear the complete story). That's why we decided to use real 10 digit phone numbers that your customers and prospects know how to use. (plus, each phone number you use has UNLIMITED keywords…that's powerful!) Lead Source Tracking When a new cell number comes in and Fix Your Funnel creates a new contact record in Infusionsoft we also apply the lead source, which is fully customizable, allowing you to track from lead to revenue! That means you'll know which lead capture situations are creating your best customers and then you'll do more of them! Creates or Updates Contact Records on the Fly When anyone sends a text message to your number and keyword Fix Your Funnel checks your Infusionsoft contacts for a match, if one is found then tags and saved data are applied to the contact it found. If the text comes from a number that doesn't exist yet, a new contact record is created. It's NEVER been this easy to grow your database! Personalize SMS Messages with any Contact Data Merge any field from a contact record into outbound and conversation text messages sent by Fix Your Funnel. That includes your custom fields! This means you can customize steps of conversations with data collected in earlier steps! Text us the keyword at the number above to see it in action! Collect ANY Data via SMS Even the best SMS systems that integrate with Infusionsoft can only collect names and email addresses. But Fix Your Funnel breaks those barriers with the addition of conversations. Now you can collect ANY data you want and drop it into any field in a contact record. The possibilities are endless! Tag Contacts When anyone sends a text message to your phone number and keywords you can tag that contact for better data segregation and to kick off campaign sequences! Add Contacts to Follow Up Sequences Even if you're an old time Infusionsoft user, who has everything set up in Follow Up Sequences, FYF SMS is for you! We support kicking off Legacy Follow Up Sequences too! We got you covered! Incoming SMS Messages in Contact Notes Every incoming text message is saved in the contact record notes giving perfect transparency. It's this kind of attention to detail that allows you to rest well at night knowing automation is working for you. One Number…Two Super Powers Every Fix Your Funnel phone number you select has two super powers…Call Monitoring & SMS. No extra charge, it's just how we roll. So now we're not only giving you super marketing powers, we're saving you from having to sign up for multiple services that are not even connected to Infusionsoft. Send us a thank you card. (Oh, yeah, we can help you with that too.) ReviewsWrite a ReviewReviewsRatings Breakdown 5 Star(47) 4 Star(4) 3 Star(0) 2 Star(0) 1 Star(2) Overall Rating4.8 Overall Rating: 4.75 Price / Value: 0 Functionality / Ease of Use: 0 Support / Documentation: 0 Felix William United States 1/22/2016 1 The support from Fix Your Funnel is a bad joke. I suscribed for the sms service but they didnt helped me to configure the service with my app, instead they asked for money. Belive me this is the worst experince i had ( i use a lot of apps from this Marketplace ) I also asked for a refund 22 days ago and didnt recive anything ( i asked for a fefund when i realized that after 1 day of "service" ) Maybe in the feature will hire moore responsable support people. Reply Neil Schneider United States 12/22/2015 5 Love this app. The staff has been helpful getting me started. The set up was easy and this is a GREAT add on for Infusionsoft. Keep up the great work! Reply Torrey Fingal United States 10/28/2015 5 FixYourFunnel is EXCELLENT!!! It is the missing link for us to really take InfusionSoft to the next level. I would highly recommend this for anyone interested in taking their customer service and satisfaction higher. Reply Dan Sanchez United States 9/9/2015 5 This is by far the most powerful application in the infusionsoft market place. Infusionsoft needs to acquire fyf and build this directly into their software. Reply Zach Hinkle United States 8/5/2015 5 We use SMS through fix your funnel and it is great. Reply Jason Hyde McHenry, IL 8/4/2015 5 We recently used the SMS Conversation tool at an event during a presentation, and the outcome was amazing! People texted a keyword to our assigned number, and the SMS Conversation tool worked like as if someone was monitoring those messages and sending back personal replys. Only it was all automated, and the replys were saved into Infusionsoft as notes, and the correct tags were applied to initiate the rest of the follow sequence. This was our first test with it, but it is now our go to tool for SMS messaging, in fact it worked so well we are trying to figure out some other ways to utilize it for our business. Reply Mark Bares United States 8/4/2015 5 Love the automated conversations and field integration - it adds another dimension of personal touch to my marketing. And segmented broadcasting with field integration and trackable links - LOVE IT!!! Reply Josh Satterlee United States 8/3/2015 5 Absolutely the best, most helpful support. The company is a true pleasure to work with and they help you build a business, not just sell you an integration. The usability is phenomenal. We saw an 47% increase in lead capture rate just by using FYF's SMS conversation. Reply Ross Walker United States 8/3/2015 5 I don't know what I would do without FYF. An absolutely amazing tool with wonderful customer service to back it up. It has become a vital part of my marketing. When it comes to using SMS in your marketing there is no other choice. Reply Lisa Rangel Rutherford, NJ 8/3/2015 5 I use Fix Your Funnel for SMS and for Sendout Cards syncing. It's been seamless and amazing for my business. The FYF team is very responsive and I recommend them highly! Reply Alfredo Lozano San Antonio, TX 8/3/2015 5 Great customer service...anytime I need clarification on how to use FYF, or better my marketing - they have come through. Reply Steve Caldwell United States 8/3/2015 5 I've used Ryan and the Fix Your Funnel Team for years. Their products are amazing and the customer support is beyond my expectations. If you want to use SMS, you have to hire FYF! Reply Stuart Bennett Broxbourne, GB 7/30/2015 5 Fix Your Funnel SMS Messaging is a really powerful tool. It enables us to have conversations over SMS and trigger custom followup based on inbound messages. We have had a bit of a learning curve in regards to getting everything setup exactly the way we want it, but the support team have been really helpful throughout this process and we finally have it exactly how we want it. I highly recommend Fix Your Funnel, and if anyone is struggling with it, I would be happy to help them get it set up. Reply Dom Cassone United States 7/22/2015 5 FYF's SMS product is very powerful and comprehensive! With the addition of Live Conversations and the corresponding mobile apps has just made it even better. Additionally, their support is superb. One of their support guys made a custom screencast for me to help answer a question that I had...that is above and beyond! Reply Joe Liu United States 7/13/2015 5 Very cool app with a lot more options then a few of the other apps out there! I think one of the best things about this is the customer support on the back end who respond very quickly and provide solid answers. This app is a game changer! Reply Winston Widdes United States 7/7/2015 5 I have been using FixYourFunnel SMS for maybe a year now. I love it! I'm so excited now that the SMS Broadcast function is a part of the service! I have some amazing artists and bands that are clients and they are going to be doing amazing things in the world and FixYourFunnel SMS will be an integral part of that. Customer service is very responsive and nice. I have met some of them personally and I feel like they are my cool tech friends. I have also had the pleasure of knowing Ryan Chapman, one of the owners for a couple years and he is humble and down to Earth and I feel like I can reach out to their company with questions or concerns and hear back quickly. I would highly recommend this service if you want to use text messaging with Infusionsoft. It is really powerful and can automate conversations with your potential clients or customers, or your existing list. Great service!!! Reply Dominic A Carubba United States 5/27/2015 5 "Nailed It!"... that sums up the value that the FYF guys have created with their platform. It is simple and effective. I signed up for FYF to use the 10-Digit SMS feature only... and in less than 24 hours before my HUGE event in Vancouver. It was so easy to use and set up that I set up 3 keywords for my 200 person audience and had 137 responses with just an announcement from the stage (didn't have time to update the powerpoint... just a verbal ask). That's impressive. I have since added some "bots" that are awesome and set up the auto dialer to have live agents make and take calls... wicked cool. Look, I've seen all kinds of systems and tools out there... FYF is EFFECTIVE. You can leverage the tools to "Super-Automate" your business processes... not just your marketing... your whole business can be automatic and you can "Nail IT" too. On the upside, the tools are simple and easy to use and there is plenty of guidance with his instructional videos. On the downside (from my professional training point of view).. I wish the instruction was in written documentation form. On the Side Side... I'm going to do my best to create that for Ryan and the FYF guys so that you will love it as much as I do... (5/27/15)... so I'm working on it because I believe in FYF that much. Thank you Ryan and all the FYF dudes! Dominic Reply ty crandall United States 4/17/2015 5 I expected it would take days to get this SMS figured out and integrated with Infusionsoft. But within an hour I was completely setup, and had two campaigns up and running. Within minutes after enrolling a receive a text and call from Fix Your Funnel. They wanted to help me get setup, but the process was so easy I didn't need any help. This was super simple to setup, seamless integration, and easy to follow tutorials for everything. This is a real game changer for our business, I didn't realize how much until we saw how it works. Great software, amazing service, it's rare to find a product and company this awesome! Reply Steve Caldwell United States 4/7/2015 5 I just used the SMS Broadcaster and love the simplicity of the service. And the service from Fix Your Funnel is absolutely the best in the business. They are always willing and competent to help you achieve your goals. Just can't recommend these guys enough! Reply Winston Widdes United States 4/3/2015 5 I love the SMS Conversations and the automated texts that can be triggered by my campaigns inside of Infusionsoft. I have one business that heavily relies on this technology and I am starting to get interest from very successful people in the entertainment industry here and in the UK. I can't say enough good things about this service, not sure why it isn't included as a part of Infusionsoft already? Reply Darcy Juarez United States 2/25/2015 5 I LOVE the texting optins with Fix Your Funnel. This is the third business that I am implementing this with and I always choose Fix Your Funnel. I like that you are announcing a phone number (which is easier for people to remember) and then I like that you can step them through the process so they only have to provide one piece of data at a time. This reduces the number of incorrect contacts that are created. Lastly I like that it becomes a conversation with the texter - in the media that they like to communicate Reply Hannah Grace United States 2/3/2015 5 Automated SMS by FixYourFunnel has not only been easy to use and implement, but the customer support has been phenomenal. When I had questions about my billing, Jon walked me through the charges step-by-step, which was extremely helpful. Furthermore, Automated SMS has been far easier for our contacts to use than CallLoop - for the same price, our opt-in rate has roughly tripled. Reply Mike Domitrz United States 1/30/2015 5 FixYourFunnel is perfect for my all of my audience members to text me and instantly receive communications to both double opt-in to my list AND receive a bonus prize. This is the ultimate solution for combining audience texting with InfusionSoft. Reply Thomas Heimann United States 1/6/2015 5 I have used Fix Your Funnel's SMS messaging and SMS conversation feature now for over a year and LOVE it! Not only do we use this in our marketing but also for our internal business processes, to notify customers or leads of important emails, sent reminders, etc. Your imagination is really the only limit as to what you can do with this too. Love how you can 'merger' any InfusionSoft field within the SMS messages. Very much a must have tool! Reply Kevin Allen United States 1/2/2015 5 The product is awesome. It's fast and in real time. It opens up the creative side to the business owner who wants to KNOW his audience Reply Nick T. Boosalis United States 12/29/2014 5 Great product easy to use. Your prospect will think they are having a conversation with someone. Lots of ways it can be used. Highly recommend it. Reply J. Hammer Helmer United States 12/21/2014 5 FixYourFunnel has a great product with even greater customer service. In today's day and age of "send us a support email, we'll get back to you sometime in the next week", it was amazing to have such great support simply by picking up the phone. Also, when things didn't work perfectly out of the gate for my purpose, they made accommodations to support me and make it work. Thanks FixYourFunnel! Reply Rondi Lambeth United States 12/17/2014 5 I use FixYourFunnel to notify my clients when their monthly payment fails. I used to spend hours on the phone each month, now I rely on FixYourFunnel to notify them, saving me several hours of work each month! Great product!!! Reply Kathy Clark United States 12/16/2014 5 This is an excellent addition to Infusionsoft! It is easy to use and has incredible results! The staff at Fix Your Funnel is very helpful too! Highly recommended!/ Reply Guillaume Couillard Montreal, CA 12/10/2014 5 The Fix Your Funnel Text messaging has been truly helpful in many of my businesses; I've used it as a Realtor to capture leads from signage with the automated SMS conversations; An Infusionsoft contact record created automatically, names, email and most importantly for realtors, the most valuable piece of information captured to follow up efficiently, the Mobile phone number; So My listing would be delivered thru email and SMS with a URL (I would even track if they looked at the listing from their SMS or from their email tag them accordingly) and I would sen my sales rep an SMS message containing the prospect infos they could be on top following up wise; My appointment cancel rate has gone down by 30% since I've been using SMS reminders sent to my prospects prior the appointments. The customer service has been very efficient the times that I've reached out; Reply Tyler Smith Kansas City, MO 12/8/2014 5 FixYourFunnel has been amazing! We use their SMS services as well as their integration with Send Out Cards. We have automated our entire on-board process with their tools. Their customer service is great too! Reply Aimee Burrell United States 12/8/2014 5 We love using the Automated SMS app to engage with potential Buyers! We have custom text riders created for each our of listings and then use this app to capture potential Buyer's info via text. Our Sellers think it is a neat marketing idea and it sets us apart from other real estate agents. Very easy to set up and Fix Your Funnel's customer service is top notch if you need some additional help! Reply Nicholas Grant United States 12/8/2014 5 We've been extremely happy with Fix Your Funnel. Their SMS feature has been instrumental in helping us collect leads during live events without sending someone to a landing page or website. Their support is excellent as well. Reply Curt Beavers United States 12/6/2014 4 We have enjoyed using the SMS features, especially the SMS broadcast. Reply Laura Posey United States 12/6/2014 5 This is wicked cool. I use it at the beginning of my speeches to collect email addresses so I can follow up with attendees during and after my presentations. Sales have gone from 10% close rate to over 30% using SMS and FYF. It is really easy to use even for a newbie. Reply Khaliq Glover United States 12/5/2014 5 I absolutely LOVE using the Automated SMS app to engage with people at my live events or webinars. There's something compelling and urgent about sending a text message to get something is return and it doesn't feel pushy and salesy. I strongly recommend using this product because I saw a significant bump in my optins as soon as I offered it as an option. Plus, some people seem to think it's really you conversing with them in real-time if they text you later, so they let their guard down a bit. One thing I would love to see is a random variable delayed response time because the replies are so fast, that's a dead giveaway that it's automated. Reply Jamar Johnson United States 12/4/2014 5 I love this app! In less than 24 hours I was sending SMS broadcast to our database and seeing a higher level engagement. Very easy to use. I highly recommend this app. Reply Colleen Sedgwick United States 12/4/2014 5 I love Fix Your Funnel services. I use it for Send Out Cards integration and SMS. It's simple and easy to use and the team is super-helpful and friendly. The customer service is outstanding! Thanks FYF! I can't even express to you how much time you save me each month. Keep up the good work! Reply Henry Evans San Diego, CA 12/3/2014 5 I've used the FixYourFunnel SMS system integrated with Infusionsoft for a while now. I've used it with direct mail pieces that have QR codes and local numbers on them, public speaking (i.e. text in to get a free gift), and in lead generation materials. Their system works well with all of them and talks directly to Infusionsoft. I also now am using it for SMS reminders so those attending live events get a further nudge to show-up a couple of hours prior. Thanks guys! Reply Tom Bottorf United States 12/3/2014 5 SMS Texting by FixYourFunnel is THE best! It continues to generate hundreds of leads for us. We use it extensively when we conduct live seminars to large audiences in high schools. All attendees... primarily moms and dads of high-school-age kids... are warm prospects at the very least. We offer free... but valuable... downloads for them, and they jump at the offer. Being able to select ANY keyword for the audience is priceless. We use the mascot of the high school as the keyword... and they LOVE it: words like stallions, comanches, dolphins, etc. SO personalized. We succeed in making them feel special. SMS Texting by FixYourFunnel has proven to be one of our best lead-generators yet! And their support is off-the-charts. Reply Robert Martinez United States 12/3/2014 5 If you do any speaking in front of groups, or heck, if you just meet and talk with people, then you need FixYourFunnel. I've been using the Automated SMS product for many months and the ease at which I grow my list, simply by asking people to send a text message, is amazing. Reply Ian Newlin United States 12/2/2014 5 I have been using this service for several months and have been very happy with it. They are offering some services that are actually useful. So many solutions do the same thing on paper but when you try to implement, it's like they never actually tried it with anyone. Fixyourfunnel seems actually interested in if their solution works for what I need. It always does what it's supposed to, and when I have questions I always get a call back the same day. Reply Paul Henshaw UK 8/6/2014 4 I have contacted this company 4/5 times now all without anything other than an automated response Reply Becky Kempton United States 2/21/2014 5 Of ALL the companies I've dealt with over the past several years, from my initial inquiry, Fix Your Funnel, has been by fair the most personal and caring. I felt like I was the only customer they had as they took time to answer each of my questions. As my business relationship developed with them, I realized the multitude of applications they offered that I could apply and how advanced and affordable their solutions were! It was then I realized there was in reality NO WAY I was their only and most important customer. And yet, they still make me feel that way and walk through every set up process until I and my staff are overly confident with how it functions. I recently ran into a snag with my phone company not allowing us to forward our number to them...decided to make the changes necessary to use their incredible call monitoring and dialer services. It's all been worth it and our Customer Phone Support is now flawless! What a relief! Now I can get back to growing my company! THANK YOU Fix Your Funnel; Thank You Ryan! :-) Reply Stacy Price United States 12/23/2013 5 After attempting to set up my first mobile marketing campaign, I had a few questions. It was late in the day, so I expected to get a response the next day. To my surprise, I got an immediate response where the Fix your Funnel guys walked me through, step by step with great explanation to ensure I knew how to set up the next one. Great product and great customer service. Reply Trent Chapman United States 1/27/2014 0 Thanks Stacy. We have made some recent improvements and put our whole team on task to ensure customers feel heard and appreciated and receive the assistance they need as soon as possible. Reply Rodney Hamp United States 10/24/2013 0 Immediately after purchasing and after spending hours upon hours trying to set the system up to meet our needs it was determined it did not function the way we needed it to. They agreed to refund our money but it been over a month and still no refund. I call and get music on hold with nobody answering. Reply Trent Chapman United States 1/27/2014 0 Hey Rodney, I verified that this was taken care of within 30 days of cancellation and a full refund was issued. If you have any further concerns, call our office and speak with Jace, Lydia, Matt or myself. Thanks. Reply Ross United States 9/18/2013 1 They were horrible. The rates were high, the support for international text messaging was not there. The servers crashed a lot and they would set their support phone number to go to an answering machine. The company is terrible and it is easy to tell they are a very very young startup with max 2 employees. Reply Felix William United States 1/22/2016 0 Very true. Reply Trent Chapman United States 1/27/2014 0 Ross, we are not sure what rates you are comparing to and apologize if you had other expectations when you signed up. Our automated SMS conversation technology is the only one of it's kind available currently in the Infusionsoft Marketplace. You are correct, we currently only support UK, US and Canada with SMS and Phone integration to Infusionsoft and updated all of our marketing and sales to reflect that so there is no misunderstanding. Due to feedback like yours, we have also upgraded our phone system so that when our customer support team members are all on calls, the sales and marketing team will get those calls as well. Our customers are our top priority as can be seen by all of our reviews of this app and other apps which we have in the Marketplace and sincerely apologize if you felt otherwise. Unfortunately for those in UK or other countries, we are a California based company and currently only have customer support 8am-6pm Pacific time and we know that isn't convenient for everyone. Reply Juan Manuel United States 4/18/2013 5 Hi Ryan. I would like to know the tariffs to outbound SMS local in USA and international. Thanks Reply Manukau 7/5/2012 0 How about New Zealand Reply Adam Love Greenlane 7/24/2013 0 Did you ever find someone in NZ to do this? Reply Trent Chapman United States 1/27/2014 0 We are working on New Zealand and Australia, but the telephony rules have caused some delay. We will reach out to you when we have an estimated launch date. Thanks. Reply Mike 7/5/2012 0 This is exactly what I want. Please let me know when this is available in South Africa. Reply Ryan Chapman 7/3/2012 0 Helen,Even though you gave us 4 stars (a little teasing), we are in the process of extending our services to Australia and most of Europe. We'll make sure to let you know as soon as it's available!Ryan Chapman(760) 621-8199 Reply Ryan Chapman 5/16/2012 0 Mike, give us a call at 760 621-8199 and we can give you some 1 on 1 training on how you can use the service! Reply Ryan Chapman 5/16/2012 0 Yeah, the USA and Canada are both supported currently! Reply Dragos 5/14/2012 0 How about Canada ? Reply Ryan Chapman 5/1/2012 0 Our service does work in the UK, but we have to manually set up the account for the time being. We're also open to connecting to existing systems. Reply Philippa 4/18/2012 0 This sounds like just what I need...Is this service available to us UK folks. Do you have a local sms service provider? If not I know someone who has a great sms system in the uk...the only drawback...not currently linked to infusionsoft. Would you be interested in connecting? Reply Arnout 11/28/2012 0 Hi Ryan,last month you were live in the UK, what about the main land in Europe?So, Netherlands? We would like to connect it to Infusion Soft, now we use bundles of Messagebird (bot no connection with Infusion Soft). Reply samuel 11/18/2012 0 Is this service available in New Zealand? Reply Ryan Chapman 11/16/2012 0 We're finally live in UK! Reply craig 8/16/2012 4 We are due to sign up with infusionsoft next week and were planning to utilise textlocal a UK based SMS inbound/outbound provider. I am interested i your service and would like to find out more info please including the cost to integrate with I/Soft and the associated monthly costs etc. Reply Helen 6/18/2012 4 How about Australia? Reply Mike 5/8/2012 5 The inbound call service is awesome, but I love that you guys bundled in the text message "auto reply" or whatever you call that function. I tested it out and it's crazy to think of all the ways texting can now be used WITH InfusionSoft. Just dumped my other service provider which DID NOT work with Infusion. Killer. Do you guys have any additional trainings or ideas on how I can use this service in a service business? I don't sell a product. Reply Troy 4/2/2012 5 We just started using the service, but we are already blown away with what we can now do with SMS+infusionsoft. Our opt in rates have gone through the roof with a new lead/traffic source using SMS. Reply Integratedhelpd... 10/9/2012 5 sweet momma, this is what the doctor ordered.SMS is a must for marketers in the digital age.It works, it is easy to use and support is good.Thanks!Mattwww.integratedhelpdesk.com Reply Nick 9/13/2012 5 Great service and cool functionality. Tying in the phone and text stuff has reduced my need for other databases outside InfusionSoft (my old short code texting database and my incoming call database are now all going through InfusionSoft). Thanks. Reply


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Rumors, leaked pictures, and supposed specifications of a tri-core Llano APU have been floating around the Web since early July, and if you had any lingering doubts that this chip was real, you can put them to rest. AMD just sent us word that it's new tri-core A6 3500 APU is shipping now and is available for less than a C-note.
The new APU features three x86 CPU cores mingling with more than 300 Radeon cores. AMD says the CPU portion races along at 2.1GHz per core, and 2.4GHz with Turbo Boost, while the integrated Radeon HD 6530D graphics is clocked at 444MHz. These are flanked by 3MB of L2 cache and carries a TDP of 65W. Here's how it compares to the other Llano APUs currently available:
AMD's new A6 3600 is so far the lowest priced Llano APU you can buy, and you're essentially trading an extra processing core for a chip that's $20 less expensive than the 3650 that also runs 500MHz slower and consumes less power. Sound like a fair deal? Tell us what you think in the comments section below.
Image Credit: AMD

subset: commoncrawl


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Lobster Medallions
- Total Time:
- 35 min
- Prep:
- 5 min
- Inactive:
- 20 min
- Cook:
- 10 min
- Yield:
- 1 serving
- Level:
- Intermediate
- About 1 pound baby lobster
- Salt
- Splash vinegar
- Laurel leaves
- Freshly ground black pepper
- Lettuce, for decoration (optional)
- About 5 ounces papaya
- About 5 ounces kiwi
- About 1/8-ounce ketchup
- About 1/4-ounce mayonnaise
- About 1/2 cup brandy
Bring a large pot of salted water to a boil, add lobster, lower the heat and cook for about 8 to 10 minutes with the vinegar, laurel and pepper.
Remove the loin of the lobster and cut it into medallions. Then prepare the lettuce bouquet and the papaya and kiwi pearls. To finalize add the sauce composed by ketchup, mayonnaise, salt, pepper and brandy.
This recipe was provided by professional chefs and has been scaled down from a bulk recipe provided by a restaurant. The Food Network Kitchens chefs have not tested this recipe, in the proportions indicated, and therefore, we cannot make any representation as to the results.
Recipe courtesy of Tivoli-Palace De Seteais


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Enter your login details for Medical Mycology Case Reports below. If you do not already have an account you will need to register here.
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K. Lagrou
Editorial Board, Medical Mycology Case Reports
Leuven, Belgium
Katrien Lagrou is currently head of the Molecular Diagnostic Laboratory of the University Hospitals of Leuven, Belgium. She obtained her Master degree in Pharmaceutical sciences from the Catholic University of Leuven in 1992. Between 1992 and 1997, she specialized in Laboratory Medicine at the same university. During this period she received a specialization degree in mycology from the Institute of Tropical Medicine in Antwerp. She received her PhD degree in 2002 and is Professor at the faculty of Medicine of the Catholic University of Leuven.Professor Lagrou's main interest is the diagnosis of fungal and viral infections in severely immunocompromised patients. She is Chair of the Microbiology Working Group of the Belgian Clinical Biology Commission, Secretary of the Belgian Society of Human and Animal Mycology and General Secretary of the European Confederation of Medical Mycology.


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Definitions for twice-baked bread
This page provides all possible meanings and translations of the word twice-baked bread
Princeton's WordNet
zwieback, rusk, Brussels biscuit, twice-baked bread(noun)
slice of sweet raised bread baked again until it is brown and hard and crisp
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Still Standing
Show Reviews (98)
One of the best sitcoms.
This remains one of my all time favorite sitcoms and for good reason. Each character is well done.
Bill is a chubby, lazy dad, similar to Homer Simpson, but not that lazy and was even trying to prove he could do stuff in one episode.
Judy has to be the funniest sitcom mom ever, sometimes going against Bill's schemes but then joins in and acts like she's still in high school, breaking the responsible mom formula found in most sitcoms.
Brian, is the most responsible member of the household, which often makes him the joke of the family, yet both Bill and Judy have admitted they would depend on Brian's success.
Lauren is the middle child of the family, suffering teenage drama, yet also showing almost zero effort in high school studies.
Tina, the youngest, is the second smartest of the children and often has better schemes and is considered quite creepy.
I love how Bill makes fun of Linda's love life.
I loved this sitcom so much that during its ABC Family run, I would get extremely angry when ABC Family would run a marathon of one of its dramas especially considering the fact that I'm not a big fan of dramas. I miss this show.moreless
Wow! Seriously, this show is NOT popular?
I don't understand how "funny" shows are not popular and don't last so long while "stupid" shows are on the air for decades. This is the most underrated, under-appreciated show I have seen EVER.
Honestly, every episode will make you laugh. It is very rare to find a show where the characters are weaved in perfectly with one another, the writing is smart (if a little lame sometimes, that's fine) and the laughs are just unexpected.
Seriously, Two And A Half Men is funnier this? Wow. Some people just don't understand entertainment.moreless
Just discovered this show
I'm working on my PC and had ABC Family on in the background. Not many shows can make me stop what I am doing and really have a good laugh. This show provided many of those moments. I have never seen a single episode of this show until now. And after watching 2 in a row, I am looking forward to watching many more.
What an awesome, hilarious show. I highly recommend it to anyone who enjoys watching family life at home.
WOW. WHAT A SHOW! I just love it so much. It is another family show that is about a wife and husband that have three kids and live together in a house. Bill and Judy and their three kids Brian, Lauren, and Tina. It's very similar to My Wife and Kids and 8 Simple Rules. Each episode is full of fresh humor and hilarity that makes me laugh in literally almost every single spoken word in literally almost every single character line. It's just freaking hysterical. After something is said, I laugh so hard that I can't forget about it and sometimes have to put the show on pause so I don't miss anything that's coming after that. Oh boy. This show is full of fun and surprises that will keep you coming back for more every time. It expresses quintessence of the typical family life at home, and shows viewers what it is like to have a family and how hard it is to raise kids. Some kids may even be able to relate the things that happen on the show to things that happen in their own lives at home. There are some episodes that are hard to understand and you sometimes have to pause it to think about what the heck they are talking about, what the heck they mean, and what the heck just happened. But that rarely happens. There are some episodes every here and there and every now and then that are boring and make you not want to watch because of that, but again this rarely happens. This show is the purest, most perfect example of family life at home and the kind of crazy situations that happen with kids. Not every episode is focused around the kids. Some episodes leave the kids completely out of it and have the adults dealing with their own problems. I like it better when the kids are involved and the very few episodes that are boring are always the ones that leave out the kids. I'm not saying all the episodes that leave out the kids and deal more with the adults are boring. A lot of them are actually as great and fun to watch as the ones that involve things with the kids. I'm just saying that the very few boring episodes are only ones that involve adults and not the kids. But there are absolutely no episodes involving the kids that are boring. I would say about 90 percent of this series involves situations with the kids, and only about 10 percent of this series leaves the kids out and deals more with the adults.
I just love the theme song. It is fun to listen to every time and is soothing to the ears. It makes you very happy and puts you into a very good mood. It brings you joy. It has the perfect melody and tune. It happens at just the right time in every episode after one character says the perfect thing that is so hilarious to hear. It goes with the flow of things in the show and just works out to be great. Regardless, this is still an awesome show in terms of episodes altogether, and I was glad to finally see another classic, light-hearted, hilarious family show that I could once again enjoy watching. It is funny and makes you laugh when you are angry, depressed, or stressed out. It can help you forget about everything that is on your mind and just relax and chill out. Even when you are feeling fine, normal, and happy, it is still funny, makes you laugh, and is something that you can enjoy and look forward to seeing.moreless
How is this show "Still Standing"....?
Horribly predictable and unoriginal, "Still Standing's" jokes fall completely flat, and it relies on every tired family TV sitcom cliché out there: the slow-witted somewhat overweight husband, the hot wife, the moody teenage daughter, and the nerdy son. This show is one of the reasons the traditional sitcom is dying.
I might also add that "Still Standing" is a complete waste of Jami Gertz and Mark Addy's talent. I've always liked these two actors in their multiple film roles, but cringe anytime each of them delivers a tiring line in this show.
To the viewers, recommendation.... Turn this drivel off, and try a classic family sitcom, like "The Dick Van Dyke Show" or "Everybody Loves Raymond", or something with more wit and originality like "Arrested Development" or "Scrubs". "Still Standing" is a waste of precious airtime.
horrible sickcom
this is a horrible sick com that never makes me laugh. The family is stupid and pathetic. The plot for all the episodes suck and all the characters are non likable. This show has never made me laugh. Even time i watch it i barf because its that bad. I'm glad that this show is over and i hope nobody watches it because if they do then they are wasting there life. I hate sickcoms like this. They try way too hard to be funny and even when they come up with a slightly funny joke they butcher it. I hate this showmoreless


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BeneFit Cosmetics Creaseless Cream Shadow/Liner in R.S.V.P.
144 reviews
72% would repurchase
Package Quality: 4.1
Price: $$$
Package Quality: 4.1
Price: $$$
INGREDIENTSIsododecane, Mica, Polyethylene, C13-16 Isoparaffin, C12-14 Isoparaffin, Lauryl Phenylisopropyl Methicone, Methyl Trimethicone, C13-15 Alkane, Polymethyl Methacrylate, Behenyl Dimethicone, Acrylates / Dimethicone Copolymer, Disteardimonium Hectorite, C20-24 Olefin, Propylene Carbonate. [+/-: CI 19140 (Yellow 5, Yellow 5 Lake), CI 42090 (Blue 1 Lake), CI 77000 (Aluminum Powder), CI 77007 (Ultramarines), CI 77163 (Bismuth Oxychloride), CI 77288 (Chromium Oxide Greens), CI 77289 (Chromium Hydroxide Green), CI 77491, CI 77492, CI 77499 (Iron Oxides), CI 77510 (Ferric Ferrocyanide, Ferric Ammonium Ferrocyanide), CI 77742 (Manganese Violet), CI 77891 (Titanium Dioxide)], N° 07108/A.
Age: 30-35
Skin: Combination, Fair-Medium, Not Sure
Hair: Black, Other, Other
Eyes: Brown
this is a pale champagne shade, can be easily and evenly applied with fingers and it really brightens up my eyes (my skin tone is slight tan with yellow undertone, ~ NW30-35); also makes the eyelashes with mascara much stand-out ;)
this cream shadow is not very pigmented as MAC paintpot, it simply provides a wash of colour. if applied too much, it may end up creasing - I tested on my oily eyelids, after 8 hours of walking in the malls and outdoor, it did crease on the lid with more product.
in my own experience, as compared to MAC paintpot and MUFE aqua cream, unfortunately this product still slightly creases. I guess the local weather here does play a part (average 30 deg Cel & 70% humidity), not many products can take on this weather and on those oily/combination skin condition. However this is still a nice product, I will test it again in non-tropical weather, hope it gets better.
Age: 25-29
Skin: Normal, Fair, Neutral
Hair: Blond, Other, Other
Eyes: Green
This has become my new every day eyeshadow! Having previously only used powder eyeshadow, I was becoming frustrated with my eyeshadow creasing and only lasting half the working day. I purchased the 'World Famous Neutrals - Easiest nudes ever' eyeshadow kit which includes two creaseless cream shadows and four powder longwear powder shadow. The two creaseless cream shadows in this kit are RSVP and No Pressure!
I applied the RSVP shadow before work at around 7am and as I continued to check it throughout the day, continued to be impressed with its staying power. It wasn't until 10pm that the shadow began to show signs of wear - and this was without using any primer! This is a very easy to wear colour and the cream is quick and easy to apply. I use my fingers to apply for day wear, but if I require a stronger colour for night wear I will apply with a brush.
Age: 18 & Under
Skin: Combination, Fair-Medium, Neutral
Hair: Brunette, Wavy, Medium
Eyes: Blue
This eyeshadow is beautiful and so pigmented but it creases if not set with powder eyeshadow but when you do it clumps and looks cakey! It is so strange. I have never experienced that before.
Age: 18 & Under
Skin: Combination, Tan, Warm
Hair: Brunette, Wavy, Medium
Eyes: Brown
This eyeshadow is amazing, it's super pigmented, long-wearing and its a beautiful color that suits a lot of skin tones. I love this eyeshadow, especially during the summer when I put less effort and time into makeup, putting this eyeshadow on with mascara is super easy but looks amazing. Since it a cream eyeshadow, it holds up a lot better in heat, humidity and even when I go swimming it manages to stay on. I have extremely oily lids and without any primer this shadow is barely creased by the end of the day. I also love how versatile this color can be: a base, a shadow, a highlight, etc. I will for sure be buying again.
Age: 19-24
Skin: Combination, Fair, Neutral
Hair: Brunette, Straight, Medium
Eyes: Brown
out of the Mac paint pots, Maybelline 24 hour color tattooes and Benefit cream shadows that i have, RSVP is my favourite cream eye shadow. If you have this you do not need Bare Study by Mac, as Bare Study (as i stated in my other review on Bare Study) is cakey and drying on my lids. Benefit cream shadows are very creamy and i feel that they will take a lot of time to dry out unlike Mac paint pots. RSVP is a soft champagne shade perfect for every day without looking over the top even if you layer other eye shadows on it. i like to wear this alone to work, and glam it up at night by adding a pink or purple under my crease and a taupe shade (Busted by Urban Decay or Satin Taupe by Mac) in the outer corner. Love this so much! will definitely repurchase.
btw i got this in a mini size which came in the Annessa's neutrals in Easiest Nudes Ever which carries 4 powder eye shadows and 2 cream shadows, the other cream shadow being in No Pressure (a light brown) which I also love.
Age: 44-55
Skin: Normal, Fair-Medium, Cool
Hair: Brunette, Wavy, Fine
Eyes: Grey
I got this shadow as part of a set. It's a pale shimmery champagne cream shadow. I like to use it lash to brow with a winged liner and a bold lip. Great staying power over a primer. Look for it in one of Benefits great sets. I find them to be a great chance to sample products you might not otherwise try.
Age: 25-29
Skin: Combination, Fair, Not Sure
Hair: Blond, Other, Other
Eyes: Other
My sister had a small sample of the R.S.V.P. benefit creaseless eyeshadow that had been sitting in her drawer for years and decided that she didn't want it anymore and "graciously" gave it to me.
I don't waste makeup so I thought I'd try it out. Although it was COMPLETELY dry and the product had shrunk I still managed to scrape some onto my eyelids.
And let me tell you... I LOVE this product! Even with its expensive price tag and poor packaging (which is why I gave it a lower lippy).
It stayed on my eyes ALL day and is perfect for a pretty look for work. I work in a hot environment so I was impressed that it stayed on as long as it did, without a primer at that!
Although I loved this product I would definitely try to find dupes before repurchasing it.. cause lets be honest..thats in intolerable price for ONE eyeshadow!
Age: 18 & Under
Skin: Very Dry, Fair-Medium, Not Sure
Hair: Brunette, Other, Other
Eyes: Brown
I wear this all over the lid + Mega Plush mascara to school most days. Purchased only a few months ago, it is now cracked, and dry, I always shut the lid. :( The color is easily duped by many different e/s I have, and the only pro left for me is that it really is creaseless...Not worth the money, get Maybelline's Color Tattoos instead. Oh, and the packaging is sturdy and really cute.
Age: 56 & Over
Skin: Dry, Fair, Neutral
Hair: Other, Straight, Fine
Eyes: Hazel
RSVP acts like a subtly glossy highlighter and/or a base. Makes other colors used with it look even better. Very versatile. The texture is a silky pleasure to use. An instant favorite in my collection.
Age: 18 & Under
Skin: Combination, Fair, Neutral
Hair: Brunette, Straight, Medium
Eyes: Blue
I love this shadow!
It is so pretty and appears kind of a nude colour. It is a very neutral colour which is nice for every day.
This also adds a nice sparkle (nothing too much, though) to your eyelids which can brighten up your face!
It's not messy, and you can apply it with your finger or a small brush.
As for pricing, I think it was something like $18 for a tiny little jar. It lasts a long time, but you can probably get a similar cream eyeshadow for a fraction of the cost.
The packaging was great because it comes in a little glass jar with a plastic screw-on lid.
I applaude BeneFit for this product!!
I've had this product now for a long time… maybe too long. Even if I wanted to use it again, I don't think I could. It's gone all hard almost, and is difficult to apply. It's cake now, too. Yuck!
I also learned that Benefit may possibly test on animals, which is a big no-no for me. So I have taken away one lippie.
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About Jeff Masters
Dr. Masters (r) co-founded wunderground in 1995. He flew with the NOAA Hurricane Hunters 1986-1990. Co-blogging with him: Bob Henson, @bhensonweather
By: Dr. Jeff Masters , 12:45 PM GMT on June 12, 2006
Alberto survived some very strong wind shear last night, and is in much better shape this morning. Deep convection for all of Alberto's life had been confined to the storm's east side, but has now built westward and almost reaches the center. Spiral banding has appeared on both visible satellite imagery and the Tampa radar animation. The storm's central pressure was a very unimpressive 1006 mb last night when I thought the storm might get ripped apart, but has dropped to 1001 mb this morning, according to the latest 8am EDT Hurricane Hunters report. Peak winds are probably around 50 mph--buoy 42003 in the Gulf of Mexico measured peak winds of 43 mph earlier this morning as Alberto passed overhead.
Figure 1. Accumulated rain so far from Alberto, as estimated by the Tampa radar.
All this strengthening occurred in the face of strong wind shear of 20-30 knots. The shear has not changed much in the past 12 hours, nor is it expected to do so over the next few days. This should limit Alberto's intensification, keeping the storm below hurricane strength. In fact, the latest visible satellite imagery shows the shear once more blowing the deep convection away from the center, exposing the center once more. I expect Alberto will undergo some fluctuations in strength over the next day as the storm battles the shear. The most likely peak winds at landfall are in the 45 - 60 mph range. Alberto has about a 10% chance of reaching hurricane strength before landfall.
The major threat of damage with Alberto now appears to be storm surge, with a surge of 4 - 8 feet possible over portions of the west coast of Florida. The waters off the coast are very shallow for a long stretch, which allows a rather large surge to build up. Heavy rain will also be a concern, but as I discussed yesterday, this may be more of a boon than a bane given Florida's moderate drought conditions. Rain amounts of up to six inches have fallen in portions of the Keys and Naples, Florida.
We'll update this blog later today as conditions warrant.
Jeff Masters
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Dr. Masters (r) co-founded wunderground in 1995. He flew with the NOAA Hurricane Hunters 1986-1990. Co-blogging with him: Bob Henson, @bhensonweather


text:
45679 by kaiserismsWatch
©2012-2016 kaiserisms
I LOVE your lines here! They demonstrate great flow and rhythm with the rest of the composition. I can feel the energy with the different pencils you used, awesome!
be cool if you did a clean version
Wow! This is superb! The style is really eyecatching!
What a bunch of characters they are!
I love your drawings!!
I love your drawings!!
I adore the liveliness of your lines. How do you do you get your characters to feel energetic like this? Is it just many many many many hours in drawing workshops or is it something else? Any secrets or tips?
Thank you!
Love the energy in this
Beautiful sketch! I love how this has so much life in it! I can just hear them all singing and the piano playing out a beautiful lively tune. There's so much detail and beautifully drawn lines in here I could sit and stare at it for hours, wondering what song they're going to start singing next.
yr sketch is wonderful!
what kind of pencils do you use?
Man! why do I even try ... XD
yet brilliant.
OOH! I love the noise in this picture. ^^
finish this plz!!!
old but very nice!!
Your sketches are the prettiest sketches <3
you are SOOO good at adding motion.
And great fun was had by all!
but amazing


text:
Four high-ranking officials at State finally resigned. But only after the report of the investigators was released. Even then, according to the news story, they did so under pressure. And only after weeks of public outrage, congressional fuming, and a continuing stream of misleading statements about the attack and what prompted it from the White House, the State Department (aka Foggy Bottom), and the administration's usual apologists. Its defenders have yet to meet a scandal they can't explain away or, failing that, try to minimize. Even a fatal lack of responsibility, like the one that led to the murderous assault at Benghazi.. .
The list of resignees reads like a Who's Who of State Department officials responsible for security, or what there was of it at Benghazi: the assistant secretary for diplomatic security, the deputy assistant secretary for embassy security, and a deputy assistant secretary responsible for overseeing U.S. diplomatic missions across a whole swath of North Africa -- from Morocco and Algeria to Tunisia and Libya.
But it's still not clear whether these dignitaries will be leaving the State Department or just their current posts. For now, according to the State Department's official spokesman, they're "on administrative leave pending further action.". .
Who knows, the people now being blamed for failing to protect our people at Benghazi may wind up being promoted. The way our ambassador to the United Nations, the Hon. Susan E. Rice, rose through the State Department's ranks after cozying up to one bloody-minded despot after another in Africa -- from Ghana to Ethiopia, Rwanda to Uganda. She seemed unable to recognize genocide on that still dark continent no matter how obvious, and certainly unable to pronounce the word -- lest she offend the genocidal.
Naturally enough, Susan Rice was being talked about not long ago as our next secretary of state -- till she made the mistake of lending herself to the Authorized Version of what had happened at Benghazi: She said it was just an outgrowth of widespread public furor over an amateurish anti-Muslim video made by some fly-by-night promoter in this country. Rather than the well-planned, premeditated terrorist assault it was, perhaps by al-Qaida and/or its affiliates. Much awaits to be revealed -- if it ever is.
Ambassador Rice's story was already unraveling even as she repeated it in one television appearance after another. In the end, rather than risk further embarrassment, the lady had the good judgment to decide she shouldn't be nominated for secretary of state after all.
Now it's said that, as a consolation prize, she'll be this president's next adviser on, of all things, national security. Perfect. There's a term for this kind of thing in Washington: falling up.. .
Once it was said that nothing succeeds like success. But in this administration -- have you noticed? -- nothing succeeds like failure.
Pulitzer Prize-winning Paul Greenberg, one of the most respected and honored commentators in America, is the editorial page editor of the Arkansas Democrat-Gazette.
Rush Limbaugh defends Rubio's debate answer: He's absolutely right that Obama knows what he's doing | Allahpundit
Time for Team Hillary to break out the gender card for young liberal women who prefer Sanders | Allahpundit


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text:
Are you Dominique Aubry?Claim your profile
Publications (10)54.77 Total impact
Article: Combinative effects of β-Lapachone and APO866 on pancreatic cancer cell death through reactive oxygen species production and PARP-1 activation[Show abstract] [Hide abstract]
ABSTRACT: Pancreatic cancer (PC) is one of the most lethal human malignancies and a major health problem. Patients diagnosed with PC and treated with conventional approaches have an overall 5-year survival rate of less than 5%. Novel strategies are needed to treat this disease. Herein, we propose a combinatorial strategy that targets two unrelated metabolic enzymes overexpressed in PC cells: NAD(P)H:quinone oxidoreductase-1 (NQO1) and nicotinamide phosphoribosyl transferase (NAMPT) using β-lapachone (BL) and APO866, respectively. We show that BL tremendously enhances the antitumor activity of APO866 on various PC cell lines without affecting normal cells, in a PARP-1 dependent manner. The chemopotentiation of APO866 with BL was characterized by the following: (i) nicotinamide adenine dinucleotide (NAD) depletion; (ii) catalase (CAT) degradation; (iii) excessive H2O2 production; (iv) dramatic drop of mitochondrial membrane potential (MMP); and finally (v) autophagic-associated cell death. H2O2 production, loss of MMP and cell death (but not NAD depletion) were abrogated by exogenous supplementation with CAT or pharmacological or genetic inhibition of PARP-1. Our data demonstrates that the combination of a non-lethal dose of BL and low dose of APO866 optimizes significantly cell death on various PC lines over both compounds given separately and open new and promising combination in PC therapy. Copyright © 2015 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.
Article: A novel anti-CD19 monoclonal antibody (GBR 401) with high killing activity against B cell malignancies[Show abstract] [Hide abstract]
ABSTRACT: CD19 is a B cell lineage specific surface receptor whose broad expression, from pro-B cells to early plasma cells, makes it an attractive target for the immunotherapy of B cell malignancies. In this study we present the generation of a novel humanized anti-CD19 monoclonal antibody (mAb), GBR 401, and investigate its therapeutic potential on human B cell malignancies. GBR 401 was partially defucosylated in order to enhance its cytotoxic function. We analyzed the in vitro depleting effects of GBR 401 against B cell lines and primary malignant B cells from patients in the presence or in absence of purified NK cells isolated from healthy donors. In vivo, the antibody dependent cellular cytotoxicity (ADCC) efficacy of GBR 401 was assessed in a B cell depletion model consisting of SCID mice injected with healthy human donor PBMC, and a malignant B cell depletion model where SCID mice are xenografted with both primary human B-CLL tumors and heterologous human NK cells. Furthermore, the anti-tumor activity of GBR 401 was also evaluated in a xenochimeric mouse model of human Burkitt lymphoma using mice xenografted intravenously with Raji cells. Pharmacological inhibition tests were used to characterize the mechanism of the cell death induced by GBR 401. GBR 401 exerts a potent in vitro and in vivo cytotoxic activity against primary samples from patients representing various B-cell malignancies. GBR 401 elicits a markedly higher level of ADCC on primary malignant B cells when compared to fucosylated similar mAb and to Rituximab, the current anti-CD20 mAb standard immunotherapeutic treatment for B cell malignancies, showing killing at 500 times lower concentrations. Of interest, GBR 401 also exhibits a potent direct killing effect in different malignant B cell lines that involves homotypic aggregation mediated by actin relocalization. These results contribute to consolidate clinical interest in developing GBR 401 for treatment of hematopoietic B cell malignancies, particularly for patients refractory to anti-CD20 mAb therapies.
Article: A critical role of autophagy in antileukemia/lymphoma effects of APO866, an inhibitor of NAD biosynthesis[Show abstract] [Hide abstract]
ABSTRACT: APO866, an inhibitor of NAD biosynthesis, exhibits potent antitumor properties in various malignancies. Recently, it has been shown that APO866 induces apoptosis and autophagy in human hematological cancer cells, but the role of autophagy in APO866-induced cell death remains unclear. Here, we report studies on the molecular mechanisms underlying APO866-induced cell death with emphasis on autophagy. Treatment of leukemia and lymphoma cells with APO866 induced both autophagy, as evidenced by an increase in autophagosome formation and in SQSTM1/p62 degradation, but also increased caspase activation as revealed by CASP3/caspase 3 cleavage. As an underlying mechanism, APO866-mediated autophagy was found to deplete CAT/catalase, a reactive oxygen species (ROS) scavenger, thus promoting ROS production and cell death. Inhibition of autophagy by ATG5 or ATG7 silencing prevented CAT degradation, ROS production, caspase activation, and APO866-induced cell death. Finally, supplementation with exogenous CAT also abolished APO866 cytotoxic activity. Altogether, our results indicated that autophagy is essential for APO866 cytotoxic activity on cells from hematological malignancies and also indicate an autophagy-dependent CAT degradation, a novel mechanism for APO866-mediated cell killing. Autophagy-modulating approaches could be a new way to enhance the antitumor activity of APO866 and related agents.
Article: The anti-lymphoma activity of APO866, an inhibitor of NAD biosynthesis, is potentialized when used in combination with anti-CD20 antibody.[Show abstract] [Hide abstract]
ABSTRACT: Abstract APO866 is an inhibitor of NAD biosynthesis which exhibits potent anti-lymphoma activity. Rituximab (RTX), an anti-CD20 antibody, kills lymphoma cells by direct apoptosis and antibody- and complement dependent cell-mediated cytotoxicities and has clinical efficacy in non-Hodgkin cell lymphomas. In the present study, we evaluate whether RTX could potentiate APO866-induced human B-lymphoma cell death and shed light on death-mediated mechanisms associated with this drug combination. We found that RTX significantly increases APO866-induced death in lymphoma cells from patients and lines. Mechanisms include enhancement of autophagy-mediated cell death, activation of caspase 3, exacerbation of mitochondria depolarization but not increase of ROS production when compared with those induced by each drug alone. In vivo, combined administration of APO866 with RTX in laboratory model of human aggressive lymphoma significantly decreased tumor burden and prolonged survival over single agent treatment. Our study demonstrates that combination of RTX and APO866 optimizes B cell lymphoma apoptosis and therapeutic efficacy over both compounds administered separately.
Article: A novel potent Fas agonist for selective depletion of tumor cells in hematopoietic transplants[Show abstract] [Hide abstract]
ABSTRACT: There remains a clear need for effective tumor cell purging in autologous stem cell transplantation (ASCT) where residual malignant cells within the autograft contribute to disease relapse. Here we propose the use of a novel Fas agonist with potent pro-apoptotic activity, termed MegaFasL, as an effective ex-vivo purging agent. MegaFasL selectively kills hematological cancer cells from lymphomas and leukemias and prevents tumor development at concentrations that do not reduce the functional capacity of human hematopoietic stem/progenitor cells both in in vitro and in in vivo transplantation models. These findings highlight the potential use of MegaFasL as an ex-vivo purging agent in ASCT.
- [Show abstract] [Hide abstract]
ABSTRACT: New derivatives of 1,4-dideoxy-1,4-imino-D-ribitol have been prepared and evaluated for their cytotoxicity on solid and haematological malignancies. 1,4-Dideoxy-5-O-[(9Z)-octadec-9-en-1-yl]-1,4-imino-D-ribitol (13, IC(50) ∼2 μM) and its C(18)-analogues (IC(50) <10 μM) are cytotoxic toward SKBR3 (breast cancer) cells. 13 also inhibits (IC(50) ∼8 μM) growth of JURKAT cells.
Article: The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies[Show abstract] [Hide abstract]
ABSTRACT: APO866 inhibits nicotinamide phosphoribosyltransferase (NMPRTase), a key enzyme involved in nicotinamide adenine dinucleotide (NAD) biosynthesis from the natural precursor nicotinamide. Intracellular NAD is essential for cell survival, and NAD depletion resulting from APO866 treatment elicits tumor cell death. Here, we determine the in vitro and in vivo sensitivities of hematologic cancer cells to APO866 using a panel of cell lines (n = 45) and primary cells (n = 32). Most cancer cells (acute myeloid leukemia [AML], acute lymphoblastic leukemia [ALL], mantle cell lymphoma [MCL], chronic lymphocytic leukemia [CLL], and T-cell lymphoma), but not normal hematopoietic progenitor cells, were sensitive to low concentrations of APO866 as measured in cytotoxicity and clonogenic assays. Treatment with APO866 decreased intracellular NAD and adenosine triphosphate (ATP) at 24 hours and 48 to72 hours, respectively. The NAD depletion led to cell death. At 96 hours, APO866-mediated cell death occurred in a caspase-independent mode, and was associated with mitochondrial dysfunction and autophagy. Further, in vivo administration of APO866 as a single agent prevented and abrogated tumor growth in animal models of human AML, lymphoblastic lymphoma, and leukemia without significant toxicity to the animals. The results support the potential of APO866 for treating hematologic malignancies.
- [Show abstract] [Hide abstract]
ABSTRACT: We developed and tested a potent hexameric Fas agonist, termed MegaFasL, for its cytotoxic effects on a panel of human haematopoietic malignant cells and healthy human haematopoietic progenitor cells (CD34+CD38low). Results demonstrated that MegaFasL induced apoptosis in cell lines and primary cells representing multiple myeloma (MM), acute myeloid leukaemia (AML), acute lymphoblastic leukaemia (ALL) and Burkitt's lymphoma. Cells from a chronic myeloid leukaemia (CML) line and from patients with chronic lymphocytic leukaemia (CLL) were resistant. Furthermore, CD34+CD38low progenitor cells were also resistant to MegaFasL. The data indicate that MegaFasL could be a highly efficient therapeutic agent ex vivo or potentially in vivo.
Article: Human tonsil implants xenotransplanted in SCID mice display broad lymphocytic diversity and cellular activation profile similar to those in the original lymphoid organ[Show abstract] [Hide abstract]
ABSTRACT: Models consisting of human immune cells in suspension transferred to severe combined immune deficient (SCID) mice have been invaluable for studying immune response, autoimmunity, and lymphomagenesis. The dissemination of human cells within the mouse body hampers immune functionality with time and favorites the development of human graft vs. mouse host (GvH) disease. To circumvent these limitations we surgically implanted tonsil pieces subcutaneously in SCID animals (hu-ton-SCID mice). Recall humoral responses was elicited and animals did not suffer from signs of GvH disease. A detailed cell subset and cell activation analysis of implants has not yet been reported. Implants from 86 hu-ton-SCID mice were evaluated by immunohistochemistry and flow cytometry analyses to assess human lymphoid cell subpopulation surviving with time after implantation, and to evaluate status of human cell activation. B cells persist over 3 months in implants. The proportion of class and type-specific Ig+ cells varied between implants, but as a whole IgG+ cells were more abundant than IgA+, and IgM+ cells, and kappa+ cells predominated over lambda+ cells. The mean proportions of these cells resemble those in the original tonsil. Fine analysis of CD19+ B cells demonstrated no expansion of activated (CD5+, CD23+, CD69+) B cells in implants compared with tonsils, and a decrease of CD19+CD77+ B cells corresponding to a centroblastic phenotype, which is consistent with the disappearance of follicular structure in implants. Double positive CD20+CD27+ memory B cells were detected in implants by immunohistochemistry. T cell CD4+CD8-/CD4-CD8+ ratios were about 4 in implants, that is similar to those in tonsils, and there was no expansion of CD3+CD4+CD8+ and of CD3+CD4-CD8- T-cell subpopulations. T cells activation markers (CD25, CD69) were similarly expressed in implants and tonsils, and implants contained cells with a memory T cell phenotype (CD45RO). Finally cells within implants depicted a low rate of proliferation when assessed by Ki-67 expression levels. Compared with original tonsils, tonsil implants in hu-ton-SCID mice lose the germinal center architecture, which is correlated with the decrease of CD77+ B cells, but conserve T and B cell subpopulation diversity, notably memory cells. In addition, implant T and B cells are not differently activated when compared with those in original tonsils and do not proliferate extensively. These observations indicate indirectly absence of GvH reaction at the cellular level in this model. Collectively, the detailed implant cellular characterization in the hu-ton-SCID model provides a strong rationale for the use of this model in the study of human recall antibody response.
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Archived Story
Group bringing BL togetherPublished 10:57am Tuesday, September 11, 2012
A new group that came together in February has residents all over the Battle Lake area working together toward a common goal of benefiting the community.
Network Battle Lake is an informal group that formed as a way to bring together businesses and organizations throughout the area to work on projects that will benefit Battle Lake and the surrounding communities. It is similar to the Forward Fergus Falls organization, said Reba Gilliand, one of the group's founders.
"It's not actually an organization, and it's not here to replace any organization," Gilliand said. "Once a week we get together with a list of ideas that people have thrown out, and we decide what we have energy around and what we have time for. If nobody else is working on something and we think it would benefit Battle Lake, we break up into subcommittees and work on it."
There are a lot of organizations in the area and people tend to get busy doing their own thing. Network Battle Lake is important because it creates some synergy for doing things together and collaborating, said Gilliand.
The group doesn't have a chairperson or executive board. The three main roles of recorder, facilitator and information communicator rotate every three months.
"It's really not a structured group," Gilliand said. "We made sure to set it up like that."
More than 100 attended the group's Celebrate Battle Lake event in June, and now they are working on two big projects: The 3/50 Campaign and Battle Lake's 125-year anniversary.
"The 3/50 Campaign is a national campaign we picked up on," Gilliand said. "The idea is for small communities to help support their local businesses. Think about three businesses you would really miss if they closed down, and make a commitment to spend $50 each month to support them."
Another way the group is helping to support local businesses is through "cash mobs." Area community members are asked to visit a specific business at a specific time and spend some money. The next cash mob is scheduled for 4 p.m. Sept. 20 at Guzzlers on Otter Tail Lake.
The group meets every Thursday morning from 7:30 to 8:45 a.m., and there is usually an attendance of about 20. Representatives from businesses and area organizations attend, and even mayor Chuck Reeve and superintendent Jeff Drake have become regulars.
All are welcome to attend meetings and provide input. More information about the group can be found at www.networkbattlelake.org.


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Find fellowships, conferences, grants and awards deadlines, workshops and networking opportunities, crowd-sourced leads to job banks, reporting toolkits, hundreds of MOOCs and more. GO >>
Are you an SEJ member who's authored, co-authored or edited a non-fiction or fiction environmental book (published in 2014 or 2015) you'd like included on this page? Documentaries are also welcome. Please send the following to web content manager Cindy MacDonald:
- a one-paragraph description
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Members' books published in: 2013, 2012, 2011, 2010, 2009, 2008, 2007 and earlier.
Advertise your 2014 or 2015 environmental book in the book-review pages of our quarterly newsletter SEJournal. For only $48 for four issues, keep your book title in front of the membership and subscribers for one full year. Complete the online form and follow the instructions for payment. SEJ members only.
"Embracing Sustainability: A Warning and a Guide for the Future of Humanity"
By Marc C. Seamon
"Embracing Sustainability: A Warning and a Guide for the Future of Humanity" was written to help people think in terms of sustainability — to help them recognize the unsustainable practices that are all around them and embrace sustainability as the only feasible model on which to build an existence that will last. It is a collection of essays that reflect on sustainability from a variety of angles. Some of the chapters are philosophical, while a few are utilitarian, explaining how and why certain aspects of society need to change to become sustainable. The book includes 65 chapters, eight color photographs and a color plate. Publisher: Marc C. Seamon, 2015. ISBN: 978-0-9968940-0-5. More information.
"How to Raise Poultry"
By Christine Heinrichs
On beyond chickens! Ducks, geese, turkeys, guineafowl and other birds have been domesticated and raised over the years. This book gives detailed history and breed information for the beginner, the experienced poultry keeper and those for whom poultry dances in their dreams. Over 200 color pictures. Revised and updated from the 2009 edition. Voyageur Press, 2014. ISBN: 978-0760345672. More information.
"Island on Fire: The Extraordinary Story of a Forgotten Volcano that Changed the World"
By Alexandra Witze (SEJ member) and Jeff Kanipe
"Island on Fire" tells the story of one of history's greatest untold natural disasters: the 1783 eruption of the Icelandic volcano Laki. Spewing out sun-blocking ash and then a poisonous fog for eight long months, the eruption's effects lingered across the world for years. It killed people from Iceland to France to Egypt, and it may have even helped trigger the French Revolution. Science writers Alexandra Witze and Jeff Kanipe explore the consequences of this little-known eruption, which underscored how a single volcano on a remote North Atlantic island can change the course of history. Laki has become a touchstone for understanding the relationship among volcanoes, climate change, and the fragility of human societies. Pegasus Books, 2015. ISBN: 978-1-60598-674-6. More information.
"Rachel Carson and Her Sisters: Extraordinary Women Who Have Shaped America's Environment"
By Robert K. Musil
Robert K. Musil's Rachel Carson and Her Sisters redefines the achievements and legacy of the environmental pioneer and scientist Rachel Carson, linking her work to a wide network of American women activists and writers, and introducing her to a new, contemporary audience. Widely known for her 1962 best-seller, Silent Spring, Carson is today often perceived as a solitary "great woman," whose work single-handedly launched a modern environmental movement. Rachel Carson was the first American to combine two longstanding, but separate strands of American environmentalism – the love of nature and a concern for human health. But as Musil demonstrates, Carson's life drew upon and was supported by already existing movements, many led by women, in conservation and public health. Rutgers University Press, 2014. ISBN: 978-0-8135-4411-3. More information.
"A River Runs Again: India's Natural World in Crisis, from the Barren Cliffs of Rajasthan to the Farmlands of Karnataka"
By Meera Subramanian
In this lyrical and intimate tapestry of five stories dealing with life, loss and survival in modern-day India, Meera Subramanian travels in search of the ordinary people and micro-enterprises rescuing India's natural world from crisis. An engineer-turned-farmer brings organic food to Indian plates. Villagers revive a dead river. Well-intentioned cook stove designers persist on a quest for a smokeless fire. Biologists bring vultures back from the brink of extinction. And in Bihar, one of India's most impoverished states, a bold young woman teaches young adolescents the fundamentals of sexual health and, in the process, unleashes their untapped potential. In these true stories, Subramanian discovers both cautionary tales and renewed hope for a sustainable and prosperous future for India. PublicAffairs, 2015. ISBN: 978-1610395304. More information.
"Still Lifes from a Vanishing City: essays and photographs from Yangon, Myanmar" (with an introduction by Emma Larkin)"
By Elizabeth Rush
In 2010, the tectonic plates beneath the junta-controlled Myanmar started to shift. As the military regime began to loosen its reins on power, it auctioned off 80 percent of the country's state-owned assets and earmarked hundreds of buildings in downtown Yangon for demolition and redevelopment. This opaque but surely profitable fire sale would profoundly reshape the country's economic landscape and the lives of those who had long called the former colonial capital of Yangon home. Elizabeth Rush, a westerner who has been reporting on South East Asia for years, made good use of strange days just before Myanmar's awakening to venture into the lost world of downtown Yangon, but it was not the large edifices of Empire that attracted her attention. Rather, she focused on the shop houses and private residences that line the alleyways and it is here, in these forgotten and secluded spaces, that the city's real secrets have been kept. After all, it was not – in the bad old days of the Burmese regime – just those who were overtly political who had to succumb to the silence. In a world where anyone accused or perceived of being on the wrong side of the regime could end up in prison with no legal recourse, people turned inwards by necessity. Only behind closed doors was it safe to indulge in private obsessions and the day-to-day worries of making ends meet. "Still Lifes from a Vanishing City" celebrates and preserves the interior lives diligently maintained despite the dictatorship's powerfully effacing reach. Things Asian Press, 2015. ISBN: 978-1934159446. More information.
"Too High and Too Steep: Reshaping Seattle's Topography"
By David B. Williams
Since settlers first arrived in Seattle, the city's citizens have altered the landscape with an unrivaled zeal. We have regraded hills, reengineered tideflats and replumbed lakes to provide better locations for business and easier ways to move through the challenging topography. And we are still at it, though now we also understand that earthquakes and rising sea levels have the potential to change us as much as we have changed the land. In "Too High and Too Steep," David B. Williams uses his deep knowledge of Seattle, scientific background and extensive research and interviews to illuminate the physical challenges and sometimes startling hubris of these large-scale transformations. Along the way, he also takes you out in the field, bringing this startling history to life. University of Washington Press, September 2015. ISBN: 978-0295995045. More information.
"Under Water: A Strong Current Trilogy Book 1"
By Greg Olmsted
In "Under Water," Liko escapes from his mother's trailer park in Las Vegas, scuba dives with his uncle in Hawaii and learns about his Hawaiian heritage. Liko's uncle, Keahi, investigates an explosion and fire at a playground. "Under Ground" introduces Keahi's workmates and exposes corruption in the Hawaii Department of Water, Wind and Sun. Gasoline continues to escape from an abandoned UST and Keahi investigates, hoping to prevent further casualties. "Under Threat" describes the dramatic effect of a catastrophic oil spill when a super tanker breaks its back off the coast of Waikiki after colliding with a longliner fishing boat. Dirty Business Publishing LLC, available Fall 2015. ISBN: 2015905323. More information.


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Black history banquet honors work done by wives of Pentecostal bishops
The volunteer community work done by the wives of black Pentecostal bishops in the Greater Pittsburgh area will be honored Monday, April 8, 2013 at the Black History Achievement Awards banquet at the Airport Marriott hotel in Coraopolis.
Thirty women, some of whom have well known ministries in their own right, will be recognized at the banquet, which is honoring the legacies of Underground Railway conductor Harriet Tubman and civil rights matriarch Rosa Parks. In some wings of the black Pentecostal tradition the title bishop is given to leaders of significant congregations as well as to those with hierarchical jurisdiction over a region.
Among those honored will be the Rev. Annette Carswell of Potter's House Ministries, the Rev. Barbara Garlington of Covenant Church of Pittsburgh, Barbara Mann of Pentecostal Temple, literacy advocate Rozelle Pamphile (whose husband is now the territorial bishop of Haiti) and the Rev. Lola M. Thorpe of the Northside Institutional Church of God in Christ.
The event is sponsored by the pastor's wives of the Church of God in Christ in western Pennsylvania. It features an all-day series of workshops on health, education and leadership trainining, as well as entertainment. Among the banquet speakers will be Brian Shirler on behalf of the National Awareness Campaign to End Domestic Child Sex Trafficking.
"We celebrate and honor those who have made a difference in their communities and who have aspired to the highest idea of commitment to their churches and family," said the announcement for the event.


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Just one question, doesn't Dita wear fur?
Dita for PETA
0 Comments
October 11, 2007
Cute Dresses for Less
Normally I avoid blogging about Bluefly...simply because their television advertisements make me want to vomit. They're not stylish, they're not clever and guess what? They aren't racy either. That said, there are a couple of cute dresses on site now, both are tempting me now that tight/boot weather is here again - finally!
Abaete's steel silk pleated 'Murray' long sleeve dress, was $405, now $243.
Design History's black wool knit turtleneck puff sleeve dress, was $100.00, now $60.00.
Abaete's steel silk pleated 'Murray' long sleeve dress, was $405, now $243.
Design History's black wool knit turtleneck puff sleeve dress, was $100.00, now $60.00.
0 Comments
October 11, 2007
Fashion Challenge - Wedding Appropriate Dresses
So, I have this wedding sneaking up on me later this month. No, not my own, but instead a New Orleans wedding for a good friend of mine. Attire has thus far been a puzzle...and then I spotted this lovely Diane von Furstenberg Celardo Tuxedo Dress. I definitely love it on the model, but what do you think? Is this wedding appropriate attire? I plan to pair it with a bold electric blue pump since I am quite tired of the obvious choice of red.
0 Comments
October 10, 2007
Current Mood - Inadequate
I swear, bloggers are taking over the world...or at least modern media these days. Exhibit a - Perez's VH1 show. Exhibit 2, er b - Diane, the lovely blogger at Bunnyshop, has written a book. No, that's not a typo...not a blog post or a newspaper article like SOME bloggers I know (me). An actual book. Said book is called Smart Girls Like Me (she's an arrogant one, that Diane...I kid, I kid) and it is garnering rave reviews from outlets like Nylon (who I just love). I suggest that you check out the synopsis here and grab a copy for yourself. Bloggers Rule! YAY!
0 Comments
October 05, 2007
A Blog Revolution at the Met
John Galliano for Dior, 1995.Image via http://www.wwd.com/
The Metropolitan Musuem of Art's Costume Exhibits are an absolute must for even casual fashion lovers. And now, the Museum is stepping boldly into the 21st century with a new exhibit, blog.mode: addressing fashion, on view Dec. 18 to April 13.
blog.mode: addressing fashion will include pieces acquired by the Costume Institute over the last seven years, including work by Azzedine Alaïa, Helmut Lang, Christian Dior, Comme des Garçons, Rudi Gernreich and Yohji Yamamoto among others. Ten computer terminals will be added to the Costume Institute galleries to allow bloggers immediate access to a Costume Institute blog to post their thoughts, reviews and criticisms.
According to WWD, the blog will be monitored daily by museum staff and remain open through the exhibit, eventually being excerpted in the official show catalog following the exhibit.
0 Comments
September 26, 2007


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Michael Sinatra serves as the Public Relations and Public Affairs Manager for Whole Foods Market's Northeast region, based in New Jersey. Michael is exceptionally passionate about food and documents his eating and foraging adventures via twitter @iateitmyway. Michael has been with Whole Foods Market® for 3 years.
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Tara eye icon gift by VictoriWindWatch
©2012-2016 VictoriWind
Daaaaaaaaaaaaaaw, tahnk you so much!!! I dint know that i will get more gifts from you!!! Wow cooool >////u////< <3 Thaaaank you!!!!! <33333
dawww im so glad you like it! <3
Ooooh how sweet! That's a nice gift and such an awesome style.
Why doesn't your ava blink?
Why doesn't your ava blink?
Awww thank you! Would you like one :3 and haha I was lazy and didn't want to XD
Ah that's the reason^^
I've no points
I've no points


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AMRUTHA SCHOOL OF PHARMACY IS INVITING FOR VARIOUS COURSES WITH APPLICATION IN KOCCHI. B-Pharmacy(regular) Limitations: Pass with 50% in intermediate. Age: As of December 31, 2014 to be between 17 and 23 years. B-Pharmacy(lateral) Limitations: D-Pharmacy (diploma in pharmacy) should pass M-Pharmacy Limitations: Pass with 50% B-Pharmacy D-Pharmacy Limitations: Pass with 50% in inter Age: … Read more
Search Results for : pharmacy scholarship renewal last date
Application are invited for full-time Ph.D. programme with scholarship in the following disciplines – Allied Health Sciences, Architecture, Atomic and Molecular Physics, Basic Science, Engineering, Geopolitics and International Relations, Information Science, Library and Information science, Nursing, Pharmacy, Philosophy and Humanities, and Statistics at Manipal University: Eligibility: Masters degree in respective subject with 60% aggregate marks. Selection … Read more
Applications are invited for Scholarship Admission Test for those candidates who took admission 2012/2013 & 2013/2014 academic years in MD Physician (Equivalent to MBBS in India) at Zaporozhye State Medical University of Ukraine, Europe with Jawaharlal Nehru Technological University Hyderabad: Selection Process: Selections will be based on the Scholarship Admission Test. How to Apply: For application … Read more
Graduate Pharmacy Aptitude Test 2015, the All India Council for Technical Education (AICTE) qualified applicants across the country who Institutes / University M-pharmacy courses for admission. Details …… Graduate Pharmacy Aptitude Test 2015 Course: M-Pharmacy Qualifications: Must B-pharmacy. Last year students can also apply. Option: a computer-based online by the Examination. Apply: Online. Start of … Read more
Bharathi Scholarship Scheme 2015-16 – Andhra Brahmin Welfare Society (www.andhrabrahmin.org) Andhra Brahmin Welfare Society Limited – Bharathi Scheme for Education after SSC 2015 Scholarships Notification under Bharathi Scheme has been released for the current academic year 2015, all the eligible candidates can apply for these scholarships to avail scholarship amount of worth Rs 10000/-, please … Read more
Telangana NMMS Scholarship Exam Hall Tickets 2015 (www.bsetelangana.org) Telangana NMMS Examination Admit Card 2015 – Directorate of Government Examinations National Means Cum Merit Scholarship Scheme Examination Admit Card 2015 has been released on its official website by Telangana Directorate of Government Examinations for the year 2015. The examination is scheduled to be conducted on November … Read more
Department of Technical Education – Andhra Pradesh / Hyderabad (DTE) Applications are invited for Diploma course in Pharmacy. Details ……… Diploma course in Pharmacy Duration: two years. Qualifications: Mathematics / Biology, Physics, Chemistry Intermediate pass. Selection: on the basis of academic merit Application: by online. Start of registration: July 2 Details regarding: July 15 … Read more
Shadan College MTech and Pharmacy Admissions 2015-16 (www.shadan.org) MTech, B Pharmacy and M Pharmacy Admissions 2015-16 – Shadan Group of Institutions Official Website: http://www.scet.in/pcmbNoti2015.pdf http://www.shadan.org/ Notification for admissions into M.Tech / M.Pharmacy courses has been released in the official website by Shadan Group of Institutions. All the interested candidates (Muslim Minority) can apply for these … Read more
The Jawaharlal Nehru University will hold Combined Biotechnology Entrance Examination for admission to (1) M.Sc. (Biotechnology); (2)M.Sc. Agri./MVSc(Biotechnology) and (3) M.Tech (Biotechnology) Programmes being offered by various participating Universities . Eligibility: For M.Sc. (Biotechnology): Bachelor's degree under 10+2+3 pattern of education in Physical, Biological, Agricultural, Veterinary and Fishery Sciences, Pharmacy, Engineering/Technology, 4-years B.Sc. (Physician Assistant … Read more


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Hello all-
I am in need of some assistance.
I am in the process of building my ultimate chopper bike. The problem i am running into is that I chopped of the original headtube to repostion it, but now need a new one that is not drilled.
I really didn't think it would be a problem to find a generic headtube but it has now become that. size is not an issue nor is weight. it just has to be around 8 to 14 inches and again not drilled.
any and all ideas or suggestions are greatly appreciated!
once i finish it i will post pictures, its going to be pretty rad.


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Front Page
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Wednesday, July 7Center for Teaching and Learning Workshop, "Deep Learning: Can You Make It Happen?," 9:30-10:30 a.m., 201 University Hall. Register online at http://www.bgsu.edu/ctl/page75113.html.Summer Colloquia, with Christopher Coyne, assistant professor of economics, West Virginia University, 12:30-2:30 p.m. Seating is limited; contact Ben Dyer at email@example.com for reservations and location information. Hosted by the Social Philosophy and Policy Center.Monday, July 12Sundaes on Mondays, free ice cream, noon-1 p.m., Falcon's Nest, Bowen-Thompson Student Union.Center for Teaching and Learning Workshop, "Foster Significant Learning Using integrated Course Design," 1-2 p.m., 201 University Hall. Register online at http://www.bgsu.edu/ctl/page11755.html.Continuing EventsJuly 6-10Summer Theater, "The Importance of Being Earnest," 8 p.m. nightly, Huron Playhouse, McCormick School, Ohio Street, Huron. Tickets are $14 for students and senior citizens, $16 for other adults, $11 for children under 12, and $13 for groups of 15 or more. Season passes are $65. For reservations, call 419-433-4744.


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Ready for una aventura in NYC? Let Dora guide you to the most family-friendly things. ¡Vámonos!
Enjoy the Tribeca Film Festival, opening day for the Mets and Yankees, the New York International Auto Show and more.
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Cofounded by selvage guru Adriano Goldschmied (creator of Diesel's jeans line) and second-generation denim manufacturer Yul Ku in 2000, this upscale label was a pioneer in the now-saturated field of high-quality blues. Though Goldschmied is no longer helming the company, its designs--crafted from Japanese and Italian fabric--are still coveted for their second-skin-like fit and worn-in feel. Plunder the label's snug downtown outpost for its AG-ed Vintage collection ($205--$325), doppelgängers for your fave ripped, faded pair, along with other classic styles.


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See definition in Oxford Advanced Learner's DictionarySyllabification: pa·per·weight
Pronunciation: /ˈpāpərˌwāt/
Definition of paperweight in English:
A small, heavy object for keeping loose papers in place.
Example sentences
- The tools of calligraphy include accessories such as penholders, brush pots, ink boxes, paperweights, seals and seal boxes.
- Common gifts were jewels, gloves, silk stockings, flowers, garters, handkerchiefs, and paperweights.
- Books can function as doorstops, paperweights, hiding places for some valuables, platforms for balancing a teacup on or props for broken chairs or tables.
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