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Durbin and Conyers. Two irresponsible big government advocates trying to dictate the state's business. At the bottom of every one of our nations problems is a corrupt congressman.
"The big online retailers aren't happy. EBay Inc. opposes the bill because it would "harm small Internet retailers" that sell products using its website, according to the L.A. Times."
This statement in your article is incorrect. Amazon, the biggest online retailer on the planet, supports the federal bill. They support it because it would simplfy sales taxes for everyone. They still support it even though they'd have to collect sales taxes everywhere if it passed.
The press, including the WSJ, have been reporting extremely poorly on this topic. The reporting has been biased, not factual, and you appear to either be incompetent, or purposly skewing your reporting to reflect your personal opinions rather than the actual facts.
Stop being crappy journalists.
There is a great opportunity for a "state rights" state like- oh, say South Carolina, or maybe Texas to opt out of this law should it pass. Then all the online retailers would relocate to that state. The retailers would benefit by not having to collect sales taxes and the state would benefit because the online retailers would bring all their jobs with them. It would be a great pro-business move that would cost the state that did it nothing.
Thousands of small businesses use the web. No one can imagine the effect of a national sales tax on the business practices and continued existence of these firms in the face of more regulations from Big Brother. Does government really need a cut? Does a state truly provide a benefit to someone who purchases something from another state? Sales taxes are already regressive, let's figure out how to get rid of them, not add a federal regulation, regulators, and more overhead.
I'm with Truly Annoyed!
" in California because the state passed a law requiring sales tax on Internet purchases."
No it didn't. It changed its definition of nexus so that Amazon and others are now viewed as having a physical presence in CA. It has zero impact on retailers that have no presence in CA.
".. or maybe Texas to opt out of this law should it pass."
Actually, the law is such that a state must opt-in to have any impact. Each state must join the Streamlined Sales and Use Tax (SSUT) group and adopt its guidelines. If a state does not do so, then they cannot compel out-of-state retailers to collect their use tax from their residents.
The location of the seller is immaterial. It is the location of the buyer. And if the buyer is in a state that adopts SSUT then the retailer can be required by that state to collect use taxes--regardless of the state the seller resides.
"No one can imagine the effect of a national sales tax..."
This is not a national sales tax.
"Does a state truly provide a benefit to someone who purchases something from another state?"
Arguably, yes.
" Two irresponsible big government advocates trying to dictate the state's business."
Interesting. Are you aware that states are generally for this legislation? It would allow states to do what they have been wanting to do for some time---force out-of-state retailers to be their tax collector for out-of-state purchases that their residents make.
Just another example of the tax and spend Soros Socialist Democratic Party. Durbin from Illinois and Conyers from Michigan. Got to get those revenues to reward those poor Union employees who are having to suffer through pensions that pay them 60-70% of their salaries after a demanding 20-25 years on the job, Woe is me..
This is nothing more that another money grab for crooked politicians to vavish on their "special interest" friends. More regulation, more compliance cost, and its all passed on to the consumer - its the Democrat way!!!
According to Reamon, if you breath the state is providing a benefit. The states are desparate for any new sources of tax receipts because the crooks that run the states have given it all away and taxpayers have to be left with something to live on. That's why people go to New Hampshire - they are tired of the high priced fairness in Massachusetts. This has nothing to do with "Faaaiiiiirrness" or main street. Misery loves company. Main Street is burdened with the states compliance and regulatory burden that they pass on as additional cost to the consumer - higher prices. Main street should worry about running their business or moving to a business friendly environment. In their never ending quest for "other peoples money" politicians will find greater job loss - because its not about job creation - its about bread and circus! Its a joke for anyone to say that in the current environment that taxpayers are getting any benfit for their tax dollars. Main Street should be lobbying the politicians for growth and job creation - not making everyone miserable.
REAL SHOOTING IN UTOYA or NORWEGIAN "AFTERLIFE" $$ FLASH MOB !!? stateofterror.blogspot.com/ or stateofterror.wordpress.com/ REAL TEARS OR TEAR GAS AND PURE THEATER ON FACES OF MANIACS !!? OSLO POLICE or COMMUNIST/LIBERAL CRIMINALS WHO WERE PREPARING FOR ACT OF TERROR AGAINST NORWAY AND EUROPE ALMOST HALF DECADE(collecting proofs and photos) AHEAD !!? WILL THERE BE APOCALYPSE NOW(Abomination) OR TOTAL RESISTANCE(civil war) !!? No doubt about bombing in Oslo, but what about shooting in Utoya !!!?
ARIZONA = UTOYA and STOLTENBERG = BREIVIK (90 minutes vs 30 and for government vehicles or police even 20 minutes the most) !!!
In a sense, SC and TX already have opted out. As this article FAILED to explain, Durbin's bill only gives the Green Light to the Streamline Sales Tax, of which there are only 24 member States. To play the game, these States would need to join SSUTA first before they can collect their lawfully due tax.
This is not a new tax. You buy online, you owe Sales (Use) Tax. It's a line item on your tax form. Sadly, States have done a poor job @ collecting or even informing the public that such law exists. No, they would rather have lawmakers come up with new, bad law that fails to address the issue, or at best, make it more complicated.
Level playing field? What a myth. B&Ms whine every time a Wal-Mart/Target move in next door. Even if Amazon did collect tax, they can still outprice a B&M bc of lower overhead. And just who is the biggest lobby of this bill? You guessed it ... Wal-Mart/Target.
This is a consumer issue, not onle for online.
Gov't dictates a sales tax on purchases and then retailers must collect the tax...keep records the gov't will dictate...tuning the retailer into a branch of the tax dept of that gov't both state and local. Suggestion: tell gov't retailer will tell them who bought what and let them figure out how to collect it. Retailers selling licenses (fish,hunt) get a percentage of the license fee. Why not the tax? Collecting and reporting sales taxes is another example of a mandate from gov't without funding (accountants don't work free).
Seems like the journalists responsible for this story were in a rush trying to catch an early jitney to the Hamptons. I hope WSJ follows up with a better story on this important issue.
California and a few other states that have tried to enforce sales taxes on affiliates soon find it's the opposite effect. California now no longer has 25,000 affiliate businesses filing state income taxes. Amazon will still sell whatever mechandise directly instead of through an affiliate. Amazon's profits go up since they are not paying the affiliate. The affiliate is no longer paying state income taxes. Only loosers here are the State of California and the affiliate. Greed gets you nothing.
Many others, like my self, simply move our affiliate business to a different state.
There is a simple solution: TaxCloud (http://taxcloud.net).
The statements by Ebay in the article confuse me. My company currently uses a PayPal checkout button that works with TaxCloud's service so my business (with less than $50k in annual sales) already calculates, collects and remits sales tax for any jurisdiction in any state. It is simpler in most cases for my business to calculate and remit sales tax than to deal with shipping.
If my business can manage to collect the legally due sales tax for my customers, why is it so hard for Ebay?
Technology available freely on the internet (like taxcloud) is more than capable of handling sales tax calculation and remittance. Sorry everyone, the "too burdensome" argument carried merit in 1967 and in 1992 (when SCOTUS last ruled on this matter), but in the era of modern computing where Ebay maintains a dominant position, multijurisdictional sales tax calculation and remittance is easily accomplished.
So what is the real reason Ebay chooses to evade supporting your schools, hospitals, infrastructure, libraries, parks and so much more?
Isn't "a national standard for collecting state and local sales taxes" an oxymoron - like Jumbo Shrimp or Microsoft Works
I run an insurance MGA (wholsaler) and we collect taxes for every state we write business in. Most of the public would be agahst the amount of state and federal taxes are in a commercial insurance policy! I agree that the the business in America should not be branch offices of state and federal tax agencies. Let the states and the fed collect there own taxes and let us run our business.
Anything from Dick Durbin should be put in the garbage can as quickly as it comes off the printer.
Mmmm.... Ayn Rand, read Atlas Shrugged!
Wasn't there a Fairness Act in that insightful novel.
The point is that it was only fair to the benificiaries, and others were made to pay for it.
like any liberal the solution is more taxes.
America's entrepeneurs are executives who build companies from the ground up. In Charge provides news, analysis and in-the-trenches commentary about small-business management. Produced by Sarah E. Needleman, Emily Maltby and Angus Loten, with contributions from the Wall Street Journal staff and others. Have a comment or tip? Write to firstname.lastname@example.com.


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The Lasting Marriage
In marriage, the ideal is lifelong commitment.
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Okay so I have read like a million (not really) forums about Maixs side being glitched or whatever. We know all the steps do the easter egg. We have tried everything.
Camping right by the buddhas, doing the train. We have all the other steps correct up until Maixs says "Reincarnation will reveal the way forward" At this point, we get stuck. We have tried getting the ballistic knife early in the round before maxis speak. We have tried getting them after he speaks. We have PaP them and have been shooting them all over the room, in the middle, on the buddhas on Russman and he won't speak!
We have not completed the Easter Egg for richtophens. We also haven't completed the Easter Egg for Tranzit. Has anyone confirmed that we need to complete maxis side on tranzit before we are allowed to do it on Die Rise?
Does the ballistic knife PaP need to be completed the same round Maixs speak??
What could we be doing wrong?
We have tried this for the passed week. We have copied every video out there, also every forum so far that has been suggested. Anyone able to help?
did you ever get past it? I know the transit has nothing to do with it as my team did maxis on transit and we are still stuck at reincarnation will reveal the way forward.


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Here are some suggested organisations that offer expert advice on adoption.
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Best Hurricanes Football Player (2006)
Kenny Phillips
He's got that University of Miami swagger, as the New York Times pointed out a few games into the Hurricanes' season last year. Granted, the team lost two games after that story, but Phillips never failed to impress. Only a freshman, the Carol City native in the #1 jersey bears the look of a classic Cane: He's fast, he's there on every play, and he's always up for a little pre-kickoff freestyle booty-shaking to get the adrenaline pumping. The Canes may not have won a national championship this time around, but the safety played every game -- every tackle -- like a winner.
More People & Places Awards
Best Place for a WalkMiami Beach Boardwalk
Best Place to Road-BikeCutler Bay
Best Place to Bird-WatchCastellow Hammock Preserve and Nature Center
Best Place to Break UpNoir Bar


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This job posting is no longer available on Indeed.
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Road Service Technician
Van-Centre Forklift is seeking a road service technician to maintain and repair a variety of forklift and other material handling equipment. Daily duties include but are not limited to driving a company provided service van between customer sites, repair of material handling equipment (forklifts, electric or gas, skid steer trucks, and dock plates), ordering parts, and maintaining customer equipment both electric and gas.
Hours will be Monday through Friday 8:00am-4:30pm
Wage is based on experience.
Van-Centre Forklift is an independent forklift repair facility; we offer our employees full benefits, a positive and fun working environment and the ability to advance within our organization. We strive to provide our customers with the service that they have come to expect from a large dealership with the rates and personable experience that come from being independent.
A successful candidate will have all or most of the following credentials
or 3rd/4th year automotive or heavy duty mechanic
this posting closes June 7th


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Are you W Wilmanns?Claim your profile
Publications (457)1237.87 Total impact
Article: Therapie der Hodgkin-Lymphome[Show abstract] [Hide abstract]
ABSTRACT: Im Rahmen einer bundesweiten multizentrischen Therapiestudie wurden zwischen Juli 1983 und Mai 1987 143 qualifizierte Patienten mit Hodgkin-Lymphom in den Stadien I-IIIA mit Risikofaktor in das HDl-Protokoll und 230 Patienten in den Stadien IIIB/IV in das HD3-Protokoll eingebracht. Im HDl-Protokoll erhielten die Patienten im Rahmen einer kombinierten Chemo-Radiotherapie 2 × COPP +ABVD und wurden dann randomisiert in eine EF-Radiatio mit 40 Gy vs. 20 Gy. Im HD3-Protokoll erhielten die Patienten eine Induktionstherapie mit 3×COPP+ABVD und wurden randomisiert in eine Konsolidierungstherapie mit Chemotherapie (l×COPP +ABVD) vs. Radiotherapie (20Gy IF). Im HDl-Protokoll erreichten 73 von 89 auswertbaren Patienten (82%) eine komplette Remission. Die Überlebenszeiten der HDl-Patienten in den Stadien I-IIIA mit Risikofaktor und von Patienten in den Stadien I-IIA ohne Risikofaktor, die lediglich eine Strahlentherapie erhielten, sind gleich. Im HD3-Protokoll erreichten 86 von 137 Patienten (63%) eine komplette Remission nach der Induktionstherapie mit 3 × COPP+ABVD. Dieses Ergebnis ist signifikant besser als die 31 % kompletten Remissio-nen in einer Pilotstudie mit ausschließlicher COPP-Chemotherapie (p 80 mm/h als wichtigster Risikofaktor für das progreßfreie Überleben.
Article: Prevention of graft‐versus‐host disease in DLA‐haplotype mismatched dogs and hemopoietic engraftment of CD6‐depleted marrow with and without cG‐CSF treatment after transplantation[Show abstract] [Hide abstract]
ABSTRACT: Prevention of graft-versus-host disease by depletion of CD6-positive T cells was studied in the dog. Donors were DLA-homozygous, recipients DLA-heterozygous with one DLA haplotype identical to the donor. Seven control dogs received untreated marrow and died of GvHD after full hemopoietic recovery within 28 days of transplantation. For prevention of GvHD, immunomagnetic separation of T cells with a monoclonal antibody against human CD6 that crossreacted with canine T cells was evaluated. Depletion of CD6-positive cells depleted CD4-positive cells completely, but only part of CD8-positive cells and DR-positive cells. CD6-depleted marrow exhibited strong nonspecific "natural" suppression of the generation of cytotoxic T cells in vitro. Eleven dogs received CD6-depleted marrow. Only 1 dog developed GvHD and died. Sustained engraftment was seen in 8 dogs. Hemopoietic recovery was delayed and slower after transplantation of CD6-depleted marrow than after transplantation of untreated marrow. Four of these dogs were treated with G-CSF, and this accelerated the recovery of leukocytes, but did not prevent rejection. Chimerism was mixed in 7 of 10 evaluable dogs and 1 dog recovered its own hemopoiesis 2 years after transplantation. CD6 depletion prevents GvHD across a DLA-haplotype difference, but rejection and mixed chimerism may occur. Treatment with G-CSF accelerates leukocyte recovery, but cannot prevent rejection.
Article: Clinical Relevance of Soluble c-erbB-2 for Patients with Metastatic Breast Cancer Predicting the Response to Second-Line Hormone or Chemotherapy[Show abstract] [Hide abstract]
ABSTRACT: Concentrations of soluble c-erbB-2 were determined in the sera of 64 patients with distant metastasis from advanced breast cancer receiving second-line hormone or chemotherapy in comparison to 35 breast cancer patients without detectable recurrent disease and 17 healthy blood donors. The sera of non-metastatic breast cancer patients contained s-erbB-2 concentrations similar to those of healthy blood donors. Patients with distant metastasis from advanced breast cancer had significantly higher values of s-erbB-2 in comparison to patients with non-disseminated disease (mean: 59.6 vs. 11.6 U/ml; p = 0.022). A significant correlation was observed between s-erbB-2 serum levels and serum LDH concentrations (p < 0.001), levels of alkaline phosphatase (p < 0.001), and the presence of hepatic metastasis (p = 0.001). Time to tumor progression was significantly shorter in patients with s-erbB-2 levels above 40 U/ml (mean: 23.4 vs. 56.7 months; p = 0.002). Furthermore, breast cancer patients with hepatic metastasis and those with elevated s-erbB-2 serum levels above 40 U/ml had limited response to hormone or chemotherapy. Non-responders had significantly higher s-erbB-2 levels (mean: 270.3, range: 42-500 U/ml;) compared with the responder group (mean: 23.1, range: 0-149 U/ml; p < 0.001). Logistic regression analysis indicated that elevated s-erbB-2 serum levels above 40 U/ml independently predicted an unfavorable response to second-line hormone or chemotherapy in patients with advanced metastatic breast cancer.
Article: Local immunotherapy of glioma patients with a combination of 2 bispecific antibody fragments and resting autologous lymphocytes: Evidence for in situ T-cell activation and therapeutic efficacy[Show abstract] [Hide abstract]
ABSTRACT: After adoptive transfer of pre-activated lymphocytes into the operation cavity of glioma patients, tumor regression and improved survival have been reported in some patients. Results were most impressive when bispecific antibodies with tumor x CD3 specificity were also applied. In this study, we attempted to avoid time-consuming pre-activation procedures for adoptively transferred cells by using a combination of bispecific antibodies directed to the EGF receptor (EGFR) on tumor cells and to CD3 and CD28 on T cells. Eleven patients with high-grade malignant glioma received 3 injections of 2 bispecific antibody fragments (EGFR x CD3 and EGFR x CD28) together with freshly isolated autologous lymphocytes via an Ommaya reservoir. Intracavitary fluid aspirated during immunotherapy was examined for markers of T-cell activation. Increased levels of soluble IL-2 receptor and TNF-alpha were detected in the intracavitary fluid of all patients tested. Two of the 11 treated patients experienced a beneficial response to therapy as defined by a transient contrast enhancement in subsequent MRI scans and prolonged survival. Side effects were transient and consisted of fever, nausea, headache and aggravation of pre-existing neurologic deficits. These adverse effects were most likely due to the antibody construct containing anti-CD3 specificity. Two patients developed cerebral edema and required steroid treatment.
Article: Local immunotherapy of glioma patients with a combination of 2 bispecific antibody fragments and resting autologous lymphocytes: Evidence for in situ T‐cell activation and therapeutic efficacy[Show abstract] [Hide abstract]
ABSTRACT: After adoptive transfer of pre-activated lymphocytes into the operation cavity of glioma patients, tumor regression and improved survival have been reported in some patients. Results were most impressive when bispecific antibodies with tumor × CD3 specificity were also applied. In this study, we attempted to avoid time-consuming pre-activation procedures for adoptively transferred cells by using a combination of bispecific antibodies directed to the EGF receptor (EGFR) on tumor cells and to CD3 and CD28 on T cells. Eleven patients with high-grade malignant glioma received 3 injections of 2 bispecific antibody fragments (EGFR × CD3 and EGFR × CD28) together with freshly isolated autologous lymphocytes via an Ommaya reservoir. Intracavitary fluid aspirated during immunotherapy was examined for markers of T-cell activation. Increased levels of soluble IL-2 receptor and TNF-α were detected in the intracavitary fluid of all patients tested. Two of the 11 treated patients experienced a beneficial response to therapy as defined by a transient contrast enhancement in subsequent MRI scans and prolonged survival. Side effects were transient and consisted of fever, nausea, headache and aggravation of pre-existing neurologic deficits. These adverse effects were most likely due to the antibody construct containing anti-CD3 specificity. Two patients developed cerebral edema and required steroid treatment. © 2001 Wiley-Liss, Inc.
Article: Kopp R, Classen S, Wolf H, Gholam P, Possinger K, Wilmanns WPredictive relevance of soluble CD44v6 serum levels for the responsiveness to second line hormone or chemotherapy in patients with metastatic breast cancer. Anticancer Res 21:2995-3000[Show abstract] [Hide abstract]
ABSTRACT: Concentrations of soluble CD44 standard (sCD44std) and CD44 variant 6 (sCD44v6) isoforms were determined in the sera of 59 patients with distant metastasis from breast cancer receiving second line hormone- or chemotherapy, in comparison to 46 breast cancer patients without detectable recurrent disease and 21 healthy blood donors. The sera of non-metastatic breast cancer, patients contained sCD44std and sCD44v6 concentrations similiar to those of healthy blood donors. In sera of patients with distant metastasis from recurrent breast cancer the median values of sCD44std and sCD44v6 were significantly higher (sCD44std: 502 ng/ml, p=0.03; sCD44v6: 193 ng/ml, p = 0.002) in comparison to healthy blood donors and patients with non-metastatic disease (p<0.001 for both parameters). A significant correlation was observed between sCD44v6 serum concentrations and the number of metastasized organs (p=0.0018), serum LDH concentrations (p<0.0001), tumor grading (p=0.025) and the presence of hepatic metastasis (p=0.028). Furthermore, sCD44v6 expression was associated with the patient's responsiveness to second line hormone- or chemotherapy. Non-responders had significantly higher sCD44v6 levels compared with the responder group (median: 447 ng/ml vs 171 ng/ml; p=0.0007). Logistic regression analysis indicated that sCD44v6 serum levels above 250 ng/ml (p =0.033) and the presence of hepatic metastasis (p=0.009) were independent factors predicting an unfavourable response to therapy.
- [Show abstract] [Hide abstract]
ABSTRACT: Retinoids are highly active for the treatment of acute promyelocytic leukemia, but have effects on many different types of normal and transformed cells. CD95 is a member of the TNF-receptor superfamily and can mediate apoptosis. In this study, we screened a series of 7 myeloid and 12 lymphoid cell lines for the expression of CD95 and for the induction of CD95 by retinoids. A differential response was observed: in 3/7 myeloid cell lines a significant down-regulation of CD95 happened which correlated with the induction of differentiation. A significant induction of CD95 was observed in 4/ 12 lymphoid lines (2 HHV8+ cell lines, one Burkitt line and another lymphoma line). The modulation of CD95 was both time- and dose- dependent (maximum reached after 3-5 days of culture with 10-6 M retinoid). The 3 retinoid compounds studied (all-trans retinoic acid, 9-cis retinoic acid and 13-cis retinoic acid) had comparable activity. Taken together, we describe a new mode of induction of CD95 in lymphoma cells. More work is needed to define the functional consequences of these changes in CD95 surface expression.
Article: Holler, E. et al. Prognostic significance of increased IL-10 production in patients prior to allogeneic bone marrow transplantation. Bone Marrow Transplant. 25, 237-241[Show abstract] [Hide abstract]
ABSTRACT: IL-10 is a potent immunosuppressant which inhibits allo-antigen-specific T cell responses. In addition, IL-10 is a strong endogenous anti-inflammatory cytokine. To investigate the role of IL-10 in the induction of acute GVHD following allogeneic bone marrow transplantation (BMT) we performed a prospective study on spontaneous IL-10 production by peripheral blood mononuclear cells (PBMNC) in 84 patients admitted for allogeneic BMT. High spontaneous IL-10 production by PBMNC at the time of admission and prior to any preparative treatment correlated with a subsequent low incidence of GVHD and transplant-related mortality (8%), as compared to patients with low or intermediate IL-10 production (50%, P < 0. 01). Our data demonstrate the prognostic significance of increased IL-10 production in BMT patients and suggest a major role of IL-10 in maintaining immunobalance in the setting of allogeneic BMT. Bone Marrow Transplantation (2000) 25, 237-241.
- [Show abstract] [Hide abstract]
ABSTRACT: The occurrence of second malignancies (SM) is an important late event following the treatment of Hodgkin's disease (HD). We sought to determine the incidence, the risk factors, and the prognosis of SM in our population of patients with HD. A total of 1120 patients diagnosed with HD were registered at six participating institutions in Munich (calendar period 1974-1994). The mean follow-up for the development of SM was 9.1 years. A cumulative treatment score was calculated for both radio- and chemotherapy. The relative and absolute risks of SM were established. All SM were investigated for response to treatment and outcome. We observed 85 SM [eight leukemias, 22 non-Hodgkin's lymphomas (NHL), two plasma cell neoplasias, and 53 solid tumors]. Five patients developed third malignancies. The relative risk of developing a second neoplasm was compared with that within the normal population and was 3.1-fold. The risk varied according to the category of SM. Higher relative risks (20.5 and 25.9-fold), but lower absolute risks were observed for leukemias and non-Hodgkin's lymphomas. Solid tumors had lower relative risks (1.8-fold). Splenectomy increased the risk of SM (relative risk 4.4-fold versus 2.7-fold). The risk of SM did not correlate with the initial treatment (radio- or chemotherapy) and did not decrease with prolonged follow-up. The cumulative intensity of radiotherapy, chemotherapy, or the two modalities combined correlated with the risk of SM. Since some cases occurred early after diagnosis, not all second neoplasms can be considered treatment-associated. After 15 years, an actuarial risk of 11.7% was calculated for all SM, of 1.0% for leukemias, of 3.0% for NHL, and of 7.7% for solid tumors. The prognosis of SM varied between good (thyroid cancer, melanoma: median survival 5+ years), average (breast cancer, NHL), and poor (acute myeloid leukemias, lung cancers: median survival 9 months). With the exception of NHL, second cancers often occurred in topographic relation to the field of previous radiotherapy. Taken together, in our patient population, we observed all three categories of SM (solid tumors, leukemias, NHL). The risk for second leukemias is lower than in previous studies, whereas the risk of second NHL is somewhat higher. We confirm that splenectomy is a possible risk factor for SM. Even after correction for the age-specific cancer incidence, treatment intensity is associated with the development of second malignant tumors. Continued follow-up is mandatory after treatment for HD. Since the prognosis of most SM is unfavorable, early recognition and prevention are of the utmost importance.
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ABSTRACT: With the growing understanding of cytostatic drug-induced programmed cell death new drug-resistance mechanisms based on the altered ability of cells to die by apoptosis have been defined. At first, the sensitive and P-glycoprotein (P-gp)-related resistant cell lines were tested to induce apoptosis by a non-P-gp transported drug, such as cytosine arabinoside (ara-C). It was demonstrated that ara-C induces apoptosis in sensitive as well as in P-gp-related resistant cell lines, as expected. Furthermore, the role of bcl-2 and bcl-xL apoptosis inhibitors as well as bax expression (apoptosis inducer) in human sensitive leukemic cell lines (CCRF-CEM and HL-60) as compared to their resistant variants such as CCRF-CEM/ACT400, CCRF-CEM/VCR1000, HL-60/IDA40, HL-60/DNR250 was evaluated. In addition to the P-gp-related resistance, a possible multidrug resistance-associated protein (MRP) and the lung resistance protein (LRP)-related resistance were assessed by flow cytometry using the monoclonal antibodies 4E3.16, MRPr1 and LRP56. Furthermore, the function of P-gp was determined with the rhodamine-123 (R-123) accumulation test. Bcl-2 and bax were analyzed by both flow cytometry and ECL Western blot, bcl-xL by ECL-Western blot alone. Comparison of the two sensitive cell lines demonstrated different bcl-2, bax and bcl-xL patterns. The common characteristic was the increased expression of one of the apoptosis inhibitor proteins, such as bcl-2 or bcl-xL. The sensitive CCRF-CEM showed a high bax level, where a decrease of about 75% in resistant variants was measured. Compared to their sensitive counterpart HL-60, a low bax expression was analyzed, which increased in the resistant variant. The common characteristic of all resistant cell lines was the decreased expression of bax compared to bcl-2 or bcl-xL. In the P-gp-related resistant HL-60/DNR250 only an increase in bcl-xL was seen, whereas in the LRP-expressing as well as P-gp and MRP negative resistant HL-60/IDA40 both apoptotic inhibitor proteins bcl-2 and bcL-xL showed maximum increase, compared to the other resistant cell lines. The P-gp-related resistant cell lines CCRF-CEM/ACT400 and CCRF-CEM/VCR1000 also showed an increased expression of both bcl-2 and bcl-xL. Summarizing these results, it was shown that the examined sensitive human leukemic cell lines and their resistant variants demonstrated a different pattern of markers for preventing and promoting apoptosis. An association between P-gp and possible LRP-expressing leukemic cells as well as apoptosis-preventing markers (bcl-2, bcl-xL) seems to exist. The clinical relevance of the coexpression of various resistance mechanisms remains to be confirmed in large leukemia patient groups.
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ABSTRACT: Glucocorticoids and fludarabine are able to induce typical features of apoptosis in CLL lymphocytes. Cysteinyl aspartate specific proteases (caspases) play a key biochemical role in the apoptotic pathway. Caspase activation following cytotoxic stimuli leads to highly specific proteolytic cleavage of functionally important cellular enzymes. One of them is poly ADP-ribose) polymerase (PARP). To some extent caspase activation seems to be under the control of the Bcl-2 family of interacting proteins. We determined the role of Bcl-2-family proteins Bcl-2 (anti-apoptotic) and Bax (pro-apoptotic), activation of caspase-3 (CPP32/Yama) and activation of PARP in CLL apoptosis. All 21 analyzed CLL samples expressed Bcl-2 and Bax. Four of 13 (31%) samples with a low Bcl-2/Bax ratio exhibited in vitro prednisolone resistance, whereas eight of nine (88%) samples with a high Bcl-2/Bax ratio were in vitro resistant (</=0.025). There was no significant correlation between clinical pre-treatment status and Bcl-2/Bax ratio. Caspase-3/CPP32 activity increase was registered after dexamethasone as well as after fludarabine treatment in CLL lymphocytes in vitro. Caspase inhibitor Z-VAD.fmk was only able to partially block dexamethasone-induced and spontaneous apoptosis but not fludarabine-induced apoptosis in CLL lymphocytes. PARP activity decreased after dexamethasone and fludarabine treatment. PARP inhibitor 3-aminobenzamide (3-AB) was able to partially inhibit dexamethasone-induced apoptosis but not fludarabine-induced and spontaneous apoptosis.
Article: GM-CSF stimulates proliferation of clonal leukemic bone marrow cells in acute myeloid leukemia (AML) in vitro[Show abstract] [Hide abstract]
ABSTRACT: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is known to stimulate granulocytes, monocytes, and macrophages. We studied the effect of GM-CSF on (clonal) bone marrow (BM) cells obtained from AML patients after 7 days of culture in vitro: BM samples were obtained from 19 AML patients at diagnosis (DIA), from two patients with persisting disease (PERS), from eight patients in complete remission (CR), and from 12 healthy donors. Flow-cytometric comparison of differentiated, CD 15-positive cells or of CD34-positive blast cells before and after cultivation showed that the proportion of CD15-positive cells was increased in nine of 12 healthy BM samples, in 14 of 19 cases at DIA, in one of three cases during PERS, and in five of six cases in CR of AML. The proportion of CD34-positive cells was increased in one of 12 healthy BM samples, in seven of 19 cases at DIA, in one of two cases during PERS, and in three of seven cases in CR of AML. Southern blot analysis (SBA) performed in six cases during the course of AML, before and after cell culture, showed that clonal DNA increased after GM-CSF treatment in three of five cases studied at DIA, in six of nine cases studied in CR, in the one case studied at PERS, and in the one studied at relapse (REL). In one case of trisomy 8 at DIA a normal karyotype was demonstrated in CR. However, after 7 days of cultivation of the cells in GM-CSF the trisomy 8 was detected in two of 17 metaphases isolated from colony-cells from methylcellulose cultures. Our data show that a 7-day treatment of BM cells with GM-CSF induced a differentiation of healthy and leukemic BM cells in the great majority of cases. An enrichment of CD34-positive cells was not achieved in healthy BM samples. However, in 70% of the cases in CR and in 30% of the cases at DIA of AML, clonal CD34-positive cells were enriched. This means that GM-CSF stimulates ('primes') leukemic cell growth in vitro.
Article: Value of human chorionic gonadotropin compared to CEA in discriminating benign from malignant effusions[Show abstract] [Hide abstract]
ABSTRACT: Human chorionic gonadotropin (HCG) is expressed in germ cell tumors and urothelial, breast, lung and colon cancers. The aim of the study was to investigate if the determination of HCG in comparison with CEA is able to discriminate between malignant and benign effusions. Effusion and partially serum samples of 61 patients with benign (g.i., heart/kidney isnuff.) and 116 patients with malignant diseases (g.i., gynec., lung, misc., CUP) were investigated. HCG was specifically determined by an IRMA using 2 monoclonal antibodies, CEA by a conventional double Ab RIA. Cytological staining was preformed using the Pappenheim-method on cytospin preparations. Significant differences (p < 0.001) were found for HCG between benign and malignant ascitic effusions with the best discrimination at 5 IU/l (ROC) and an overall sensitivity of 31.3% (spec. vs benign eff. 93.4%) increasing in subgroups from hematol. (5.8%) < misc. (31.3%) < gynec. (32.1%) < g.i. (36%) < lung (38.1%) to CUP (50%). CEA also showed significant differences between benign and malignant total and ascitic effusions, and weaker for the pleural subgroup (cutoff 9 ng/ml) with a total sensitivity of 44.6% (sp = 100%) increasing from misc. (30.8%) < lung (47.1%) < CUP (50%) < gynec. (60%) < g.i. (60.9%). Comparative cytology and TM determinations increased the positiverate of cytology (45.2%) to 58.3% for either cytology or HCG positive cases, or to 61.6% for either cytology or CEA positive cases. For the combined determination of cytologoy and HCG and CEA, the overall TM positive rate for 33 cytology-pos. cases was 78.8%, but in 40 cytology-negative cases 37.5% for TM positive cases. In conclusion HCG is useful in ascitic > pleural effusions with high specificity (90% at 5 IU/l) but low sensitivity of 31% increasing in g.i., lung and gynecologic cases, CEA a more general TM with higher sensitivity of 45% increasing in g.i., gynecologic and lung cases (sp. 100% at 9 ng/ml) both adding significantly to cytology-negative effusions.
- [Show abstract] [Hide abstract]
ABSTRACT: Human parvovirus B19 can persist in immunocompromised patients and may produce severe clinical illness. In this retrospective study the incidence of B19-associated infections in bone marrow transplant patients was investigated. During 1 year 60 patients received bone marrow grafts (eight autografts and 52 allogeneic transplantations). In case of early onset, atypical or steroid-resistant erythrodermia the patients' blood and/or tissue specimens were screened for B19 infection by polymerase chain reaction (PCR). Additionally, specimens of patients with severe organ failure were tested. A total of 64 PCRs was performed in 27 patients. Seven patients with erythrodermia and one with vulvovaginitis proved to be PCR positive. In patients with organ failure B19 DNA was detected in the myocardium and liver. The incidence of B19 infections in this cohort was 15% and the B19-associated mortality rate 7%. In conclusion, parvovirus B19-associated infections may be more common in immunocompromised patients than previously anticipated.
Article: P53-immunoreactive cells in benign and malignant effusions: diagnostic value using a panel of monoclonal antibodies and comparison with CEA-staining[Show abstract] [Hide abstract]
ABSTRACT: The diagnosis of malignancy in peritoneal and pleural effusions can be difficult, because activated mesothelial cells may resemble malignant cells. P53 mutations are the most frequent genetic changes in human cancer and translate into an overexpression of the p53 protein detectable by immunocytochemistry. In this study, we investigated the sensitivity and specificity of 4 different monoclonal antibodies (moAB) against p53 for the diagnosis of malignancy in effusions. We also compared p53 staining with CEA immunocytochemistry which previous work had established as a specific marker of malignancy in body cavity effusions. Normal and malignant cells from 28 benign and 52 malignant effusions (pleura and ascites) were examined by indirect immuno-alkaline phosphatase method. Four different moAB against p53 (PAB 1801, PAB 240, DO-1 and DO-7) and one moAB against CEA (CEA-84) were used. Antibodies p1801, p240 and DO-1 react with 52-75% of cases of effusions with malignant cells, but also with 38-80% of benign effusions. Only the antibody DO-7 and the CEA moAB show specificity for malignant cells reacting respectively with 20 (55%) of cases. A combination of these 2 markers does not enhance the sensitivity for the detection of tumor cells. No direct correlation between CEA and p53 immunostaining could be established. The sensitivity and specificity of staining p53 in malignant cells by immunocytochemistry depend strongly on the antibody used. Some p53 moAB are positive with reactive cells in ascites and pleural effusions. Currently, p53 staining of expressing cells does not improve the identification of malignant cells in comparison with CEA immunocytochemistry, but may help to screen for patients with p53 mutations.
Article: Tumor growth inhibition with bispecific antibody fragments in a syngeneic mouse melanoma model: The role of targeted T-cell costimulation via CD28[Show abstract] [Hide abstract]
ABSTRACT: The ability of bispecific antibodies with anti-tumor x anti-CD3 specificity to mediate the killing of tumor cells by activated T cells has been demonstrated in many in vitro experiments. Moreover, long-term survival of lymphoma-bearing mice has been observed after treatment with such reagents. The therapeutic effect of bispecific antibodies in solid-tumor models has been less impressive, in particular if fragmented antibodies were used to avoid systemic T-cell activation by bispecific constructs binding to Fc-receptor-positive cells. Here we report that bispecific anti-tumor x anti-CD3-fragments markedly inhibit intraperitoneal as well as pulmonary tumor growth in mice inoculated with B16 melanoma cells, resulting in the long-term survival of animals. Therapeutic success critically depends on the number of recruitable effector cells at the site of tumor growth. A second bispecific construct triggering the co-stimulatory CD28-molecule on the T-cell surface increased tumor-cell killing in vitro and in vivo, despite rather low avidity of this reagent to mouse T cells. Finally, long-term-surviving animals showed improved survival after i.v. rechallenge with tumor cells, indicating that bispecific antibodies are capable of inducing long-lasting protective immunity.
Article: Determination of thymidine phosphorylase activity in leukemic blast cells by a high-performance liquid-chromatographic assay[Show abstract] [Hide abstract]
ABSTRACT: A high-performance liquid chromatographic (HPLC) method has been developed for measuring thymidine and thymine levels, so these could be used to determine thymidine phosphorylase (TP) activity. The method described has the selectivity to separate the analytes from an enzymatic reaction mixture without mutual disturbance. Correlation of peak areas of thymine, thymidine, and 2-thio-6-azauridine with amounts in standards and spiked matrices was linear in the concentration range 0.04–2 μg mL−1 for 2-thio-6-azauridine, 0.08–3 μg mL−1 for thymine, and 0.02–2.5 μg mL−1 for thymidine. Intra- and interday precision were measured by analyzing the retention times of replicate standards or spiked matrices within one (intra assay,n=8) and eight consecutive days (inter assay,n=8) over the concentration ranges 0.1–0.8 μg mL−1 for thymine, 0.02–0.4 μg mL−1 for thymidine, and 0.1–0.5 μg mL−1 for 2-thio-6-azauridine. Recovery was monitored by use of 2-thio-6-azauridine as internal standard. The precision, accuracy, and speed of the method were excellent. The smallest detectable (LOD) and quantifiable (LOQ) quantities were, respectively, 1.3 ng mL−1 and 3.4 ng mL−1 for thymine, 2.68 ng mL−1 and 7.46 ng mL−1 for thymidine, and 1.7 ng mL−1 and 4.92 ng mL−1 for 2-thio-6-azauridine. At 25°C the TP reaction was linear for at least 45 min. At 37°C the reaction occurred much faster and was linear for 15 min only. We decided, therefore, to quantify thymidine and thymine after an incubation time of 30 min at 25°C. The Michaelis constant (K M=59 nmol) and maximum enzymatic reaction velocity (v max=1.626 nmol min−1×106 cells) for TP were determined by extrapolation of the regression line (y=32.53x+90.73;r=0.992) to thex andy axes, respectively. Enzymatic activity was calculated from: - Activity (units×1010 cells)=(A thymidine 30 min−A thymidine 0 min)×0.00021, - whereA is the peak area from the chromatogram.
Article: Tumor‐growth inhibition with bispecific antibody fragments in a syngeneic mouse melanoma model: The role of targeted T‐cell co‐stimulation via CD28[Show abstract] [Hide abstract]
ABSTRACT: The ability of bispecific antibodies with anti-tumor × anti-CD3 specificity to mediate the killing of tumor cells by activated T cells has been demonstrated in many in vitro experiments. Moreover, long-term survival of lymphoma-bearing mice has been observed after treatment with such reagents. The therapeutic effect of bispecific antibodies in solid-tumor models has been less impressive, in particular if fragmented antibodies were used to avoid systemic T-cell activation by bispecific constructs binding to Fc-receptor-positive cells. Here we report that bispecific anti-tumor × anti-CD3-fragments markedly inhibit intraperitoneal as well as pulmonary tumor growth in mice inoculated with B16 melanoma cells, resulting in the long-term survival of animals. Therapeutic success critically depends on the number of recruitable effector cells at the site of tumor growth. A second bispecific construct triggering the co-stimulatory CD28-molecule on the T-cell surface increased tumor-cell killing in vitro and in vivo, despite rather low avidity of this reagent to mouse T cells. Finally, long-term-surviving animals showed improved survival after i.v. rechallenge with tumor cells, indicating that bispecific antibodies are capable of inducing long-lasting protective immunity. Int. J. Cancer 80:138–144, 1999. © 1999 Wiley-Liss, Inc.
Article: Cytokines in GvH and GvL
Article: Tumor-growth inhibition with bispecific antibody fragments in a syngeneic mouse melanoma model: The role of targeted T-cell co-stimulationvia CD28
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text:
The Reorganization of Inventive Activity in the United States during the Early Twentieth Century
In: Understanding Long-Run Economic Growth: Geography, Institutions, and the Knowledge Economy
The standard view of U.S. technological history is that the locus of invention shifted during the early twentieth century to large firms whose in-house research laboratories were superior sites for advancing the complex technologies of the second industrial revolution. In recent years this view has been subject to increasing criticism. At the same time, new research on equity markets during the early twentieth century suggests that smaller, more entrepreneurial enterprises were finding it easier to gain financial backing for technological discovery. We use data on the assignment (sale or transfer) of patents to explore the extent to which, and how, inventive activity was reorganized during this period. We find that two alternative modes of technological discovery developed in parallel during the early twentieth century. The first, concentrated in the Middle Atlantic region, centered on large firms with in-house R&D labs and superior access to the region's rapidly growing equity markets. The other, located mainly in the East North Central region, consisted of smaller, more entrepreneurial enterprises that drew primarily on local sources of funds. Both modes seem to have made roughly equivalent contributions to technological change through the 1920s. The subsequent dominance of large firms seems to have been propelled by a differential access to capital during the Great Depression that was subsequently reinforced by the regulatory and military procurement policies of the federal government.
(This abstract was borrowed from another version of this item.)
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References listed on IDEAS
Please report citation or reference errors to , or , if you are the registered author of the cited work, log in to your RePEc Author Service profile, click on "citations" and make appropriate adjustments.:
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- Eytan Sheshinski & Robert J. Strom, 2007.
"Introduction to Entrepreneurship, Innovation, and the Growth Mechanism of the Free-Enterprise Economies
[Entrepreneurship, Innovation, and the Growth Mechanism of the Free-Enterprise Economies]," Introductory Chapters, Princeton University Press.
- Teece, David J., 1993.
"Profiting from technological innovation: Implications for integration, collaboration, licensing and public policy,"
Research Policy,
Elsevier, vol. 22(2), pages 112-113, April.
- Teece, David J., 1986. "Profiting from technological innovation: Implications for integration, collaboration, licensing and public policy," Research Policy, Elsevier, vol. 15(6), pages 285-305, December.
- Cull, Robert & Davis, Lance E. & Lamoreaux, Naomi R. & Rosenthal, Jean-Laurent, 2006.
"Historical financing of small- and medium-size enterprises,"
Journal of Banking & Finance,
Elsevier, vol. 30(11), pages 3017-3042, November.
- Robert Cull & Lance E. Davis & Naomi R. Lamoreaux & Jean-Laurent Rosenthal, 2005. "Historical Financing of Small- and Medium-Sized Enterprises," NBER Working Papers 11695, National Bureau of Economic Research, Inc.
- Tom Nicholas, 2008. "Does Innovation Cause Stock Market Runups? Evidence from the Great Crash," American Economic Review, American Economic Association, vol. 98(4), pages 1370-96, September.
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"Competition among the exchanges before the SEC: was the NYSE a natural hegemon?,"
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text:
- 141Promote
Tote Bag
Nikiby Maria Jose Da Luz
Our quality crafted Tote Bags are hand sewn in America using durable, yet lightweight, poly poplin fabric. All seams and stress points are double stitched for durability. Available in 13" x 13", 16" x 16" and 18" x 18" variations, the tote bags are washable, feature original artwork on both sides and a sturdy 1" wide cotton webbing strap for comfortably carrying over your shoulder.
Tribute to a beautiful dog that now is in heaven
It's really cute work, but sad :)
Indeed, she will be missed forever :( But we keep great memories of her also. Thank you olivia!
awh, i know what that is like maria...sorry for your loss but now you have another guardian angel...amazing tribute!
We actually lost 2 of our 4 doggies last year it was so sad. I made a children story inspired on them and all the love they gave us. In case youd like to see https://www.behance.net/gallery/Album...
s/13129075 . And thank you soaring :)
Maria, the book looks so amazing, as is all your work! I'm a fan! :)
i'm so sad for your losses :( ... But that is such a lovely tribute to your sweet angels! 😇😇
i'm so sad for your losses :( ... But that is such a lovely tribute to your sweet angels! 😇😇
Aw thanks so much is really nice to hear that!
Big hug!
Big hug!
so cool! LOVE!
Thank ben :D
:))) love Maria!!!!
So cute!
Super cute! Awesome work
very kool
So lovely!
how lovely!
Cool pattern! Love that mug!
so cute!
So cool! Adorable pattern!~
It's so fun. I love it.
See More Comments


text:
J.K. Adams 12" x 12" Fair Haven Slate Server VSR 1212 FH
|This elegant 2" x 12" Fair Haven Slate Server from J.K. Adams is perfect for serving artisanal cheeses and hors d'oeuvres. The natural slate surface is beautiful and food safe. The server has nonslip cork feet to protect your table top and easily wipes clean with a damp sponge. Measures 12" l x 12" w x 3/8" h.
J.K. Adams Artisan Paddle Cutting Board ART PDL
|Rustic appeal comes to your kitchen with the J.K. Adams Artisan Paddle Cutting Board. Each handmade, maple cutting board is sanded smooth and is so lightweight that it's so easy to tote around by the extended paddle handle. The 17 3/4" x 11" surface area makes for plenty of room to prepare several foods at the same time and is perfect for use as a serving tray when entertaining guests. Made in the USA.


text:
Ideas of the 1960s have now grown reactionary in our world that is vastly different from a half-century ago.
Take well-meaning subsidies for those over age 62. Why are there still senior discounts, vast expansions in Social Security and Medicare, and generous public pensions?
Five decades ago all that made sense. There was no such thing as double-dipping. Seniors often were physically worn out from blue-collar jobs. They were usually poorer and frequently sicker than society in general. The aged usually died not long after they retired.
Not now. Seniors often live a quarter-century or longer after a mostly white-collar retirement, drawing subsidies from those least able to pay for them.
Seniors are not like today's strapped youth, scrimping for a down payment on a house. Most are not struggling to find even part-time work. None are paying off crushing student loans. In a calcified economy, why would an affluent couple in their early 60s earn a "senior discount" at a movie, while the struggling young couple with three children in the same line does not?
Affirmative action and enforced "diversity" were originally designed to give a boost to those who were victims of historical bias from the supposedly oppressive white-majority society. Is that still true, a half-century after these assumptions became institutionalized?
Through greater intermarriage and immigration, America has become a multiracial nation. Skin color, general appearance, accent or the sound of one's name cannot so easily identify either "oppressors" or "victims."
So who exactly should receive privileges in job-hiring or college admissions -- the newly arrived Pakistani immigrant, or the third-generation, upper-middle-class Mexican-American who does not speak Spanish? Both, or neither? What about someone of half-Jamaican ancestry? What about the children of Attorney General Eric Holder or self-proclaimed Native American Sen. Elizabeth Warren? What about the poor white grandson of the Oklahoma diaspora who is now a minority in California?
Even if the 21st-century state could define who is a minority, on what moral grounds does the targeted beneficiary deserve special consideration? Is his disadvantage defined by being poorer, by lingering trauma from his grandparents' long-ago ordeals, or by yesterday's experience with routine racial prejudice?
Rush Limbaugh defends Rubio's debate answer: He's absolutely right that Obama knows what he's doing | Allahpundit
Time for Team Hillary to break out the gender card for young liberal women who prefer Sanders | Allahpundit


text:
- 498Promote
Throw Pillow
A Beautiful Mindby Kavan And Co
Throw Pillow made from 100% spun polyester poplin fabric, a stylish statement that will liven up any room. Individually cut and sewn by hand, each pillow features a double-sided print and is finished with a concealed zipper for ease of care. Sold with or without faux down pillow insert.
Totally true. I adore this!
love it:)
Smart and beauty! :)
whoa! beautiful
this is sweet!!!
Fantastic man, really inspiring
Incredibly good!
Just gorgeous
Good stuff!
Oh yeah, nice typography. I can't construct something like this for the life of me. Well done, buddy! :p
Nice touch!
Great stuff, keep it up.
The colours are wonderful. I love the «wisest», it's fantastic!
Your artworks are delightful, great!
Awesome types
Can this rug have the design in portrait instead of landscape? It seems to cut off the design in landscape
Great Work!
See More Comments


text:
MONDAY, Dec. 12 (HealthDay News) -- The poet Emily Dickinson greatly feared the "narrow fellow in the grass," writing that she "never met this fellow/Attended or alone/Without a tighter breathing/And zero at the bone."
Dickinson was not alone in her ophidiophobia (fear of snakes) and, it turns out, humans have good reason to fear the slithering serpent, whether it is found in the grass or elsewhere.
A new study in the Dec. 12-16 early edition of the Proceedings of the National Academy of Sciences documents frequent python attacks on a tribe of preliterate, hunter-gatherers in the Philippines, one of the first studies to actually quantify the danger that snakes pose to humans.
And the danger, it turns out, is quite real, at least among the Agta Negritos of Luzon Island.


text:
Zenescope Madness of Wonderland by Elias-ChatzoudisWatch
©2013-2016 Elias-Chatzoudis
Both of them look hot!
i want to print this out and color it and repost it if allowed
can I color it?
You can't imagine how much of a fan I am of your pictures :3 I even made my own wallpaper with a mix of you're picture for myself please give birth to my kids ! haha :3
i thought elias was a guy? haha
This pic is totally awesome! I love it!
nice look....
I really admire people who can draw attractive women. I can draw women sort of, but unless copying a face, I cannot make them attractive.
Ooo, I wonder what this would look like colorized...
9_9 ffs.
Very nice!
Beautiful, your line work is amazing
Brother you are just awesome one of my favorites
awesome! may I ask if you do these for comissions?
I ussually don't make backgrounds at the commissions.
very awesome


text:
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Tumble dryers up to £200?(7 Posts)
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- Homepage >
- News Archives >
- Article
US Army in Europe Soldiers win 2014 AG Corps Regimental Award
May 2, 2014
WIESBADEN, Germany -- U.S. Army in Europe Soldiers were selected as winners for the 2014 Adjutant General Corps Regimental of the Year Awards.
The purpose of these awards are to give special recognition to Soldiers who best understand the importance of contributions and values in their dealings with Soldiers, commanders, families, and the Army during the previous calendar year.
The winners are:
Capt. Joseph H. Johnson III, HHC, Allied Forces North Battalion, was awarded the Timothy J. Maude Medal for Distinguished Achievement, AG Corps Regimental Officer and Warrant Officer of the Year.
Staff Sgt. Andrewmane O. Bowes, Charlie Company, Allied Forces South Battalion, was awarded the Larry L. Strickland Medal for Distinguished Achievement, AG Corps Noncommissioned Officer and Soldier of the Year.
To find out more about the competition or the AG Corps, visit their website.


text:
Overnight Savory French Toast
This savory, feeds-eight French toast — a cost-effective, cheese-crusted combo of baked bread, eggs, and Gruyère — rests overnight so you can sleep in.
Level: Easy
Yield: 8 main-dish servings
Serves: 8
Advertisement - Continue Reading Below
- 6 large eggs
- 2 c. milk
- 1 tbsp. Dijon mustard
- salt and pepper
- ¼ c. snipped chives
- 1 loaf French bread (preferably day-old; see Shopping Tip)
- 6 oz. Gruyère cheese
- Grease shallow 1 1/2-quart ceramic baking dish. In medium bowl, whisk eggs, milk, Dijon, 1/4 teaspoon salt, and 1/4 teaspoon freshly ground black pepper until well blended. Stir in chives.
- Arrange half of bread in bottom of prepared baking dish, overlapping slices to fit. Pour half of egg mixture over bread and sprinkle with two-thirds of Gruyère. Cover with remaining bread, overlapping slices. Pour remaining egg mixture over bread; gently press down to help bread absorb egg mixture. Sprinkle with remaining one-third of Gruyère. Cover and refrigerate overnight.
- Preheat oven to 350°F. Bake 50 to 60 minutes or until puffed and golden and tip of knife inserted in center comes out clean, covering top during last 15 minutes if browning too quickly. Let stand 10 minutes to set custard before serving. Sprinkle with snipped chives.
Tips & Techniques
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text:
, Volume 13, Issue 2, pp 241-267
First online:
Detecting change in UK extreme precipitation using results from the climateprediction.net BBC climate change experiment
- Hayley J. FowlerAffiliated withSchool of Civil Engineering and Geosciences, Newcastle University Email author
- , Daniel CooleyAffiliated withDepartment of Statistics, Colorado State University
- , Stephan R. SainAffiliated withInstitute for Mathematics Applied to Geoscience, National Center for Atmospheric Research
- , Milo ThurstonAffiliated withOxford e-Research Centre, Oxford University
We investigate a question posed by policy makers, namely, "when will changes in extreme precipitation due to climate change be detectable?" To answer this question we use climateprediction.net (CPDN) model simulations from the BBC Climate Change Experiment (CCE) over the UK. These provide us with the unique opportunity to compare 1-day extreme precipitation generated from climate altered by observed forcings (time period 1920–2000) and the SRES A1B emissions scenario (time period 2000–2080) (the Scenario) to extreme precipitation generated by a constant climate for year 1920 (the Control) for the HadCM3L General Circulation Model (GCM). We fit non-stationary Generalized Extreme Value (GEV) models to the Scenario output and compare these to stationary GEV models fit to the parallel Control. We define the time of detectable change as the time at which we would reject a hypothesis at the α = 0.05 significance level that the 20-year return level of the two runs is equal. We find that the time of detectable change depends on the season, with most model runs indicating that change to winter extreme precipitation may be detectable by the year 2010, and that change to summer extreme precipitation is not detectable by 2080. We also investigate which climate model parameters affect the weight of the tail of the precipitation distribution and which affect the time of detectable change for the winter season. We find that two climate model parameters have an important effect on the tail weight, and two others seem to affect the time of detection. Importantly, we find that climate model simulated extreme precipitation has a fundamentally different behavior to observations, perhaps due to the negative estimate of the GEV shape parameter, unlike observations which produce a slightly positive (∼0.0–0.2) estimate.
KeywordsExtreme precipitation Detection Climate change Climateprediction.net Parameters Generalized extreme value
AMS 2000 Subject Classifications62-statistics
Reference tools
- Title
- Detecting change in UK extreme precipitation using results from the climateprediction.net BBC climate change experiment
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
- Journal
Volume 13, Issue 2 , pp 241-267
- Cover Date
- 2010-06
- 10.1007/s10687-010-0101-y
- Print ISSN
- 1386-1999
- Online ISSN
- Publisher
- Springer US
- Additional Links
- Topics
- Keywords
- Extreme precipitation
- Detection
- Climate change
- Climateprediction.net
- Parameters
- Generalized extreme value
- 62-statistics
- Industry Sectors
- Authors
- Hayley J. Fowler (1)
- Daniel Cooley (2)
- Stephan R. Sain (3)
- Milo Thurston (4)
- Author Affiliations
- 1. School of Civil Engineering and Geosciences, Newcastle University, Newcastle upon Tyne, UK
- 2. Department of Statistics, Colorado State University, Fort Collins, CO, USA
- 3. Institute for Mathematics Applied to Geoscience, National Center for Atmospheric Research, Boulder, CO, USA
- 4. Oxford e-Research Centre, Oxford University, Oxford, UK


text:
While I'm on break from the Revolutionary War zombies… (I've got about 1500 words to go.)
(1) I found this truly inspired response from Evil Monkey to the Lev Grossman article.
(2) Speaking of diabolic nonhumans, Angry Piggy's return to cable the ning should be appearing late this evening or tomorrow morning. I also make a guest appearance. ;)
(3) Btw, she will have a vlog challenge for you. Pay attention.
(4) We haven't had a Wiki challenge in a while…Cherylz?
(5) "Mafia sank nuclear waste ship." No, really.


text:
Enter your login details for Biochemical Pharmacology below. If you do not already have an account you will need to register here.
Check submitted paper
Track accepted paper
Once your article has been accepted you will receive an email from Author Services. This email contains a link to check the status of your article. Track your accepted paper
J.G. Piette
Editor, Biochemical Pharmacology
Université de Liège, Liège, Belgium
Jacques Piette is Editor of Biochemical Pharmacology, Professor of Molecular Biology & Virology at the University of Liège and Director of the GIGA-Research which is an interdisciplinary research center in Biomedical Sciences. His research interests are mainly focused on the signal transduction machinery in immune cells leading to the activation of various transcription factors controlling the response of infection by pathogens. He is also involved in projects dealing with tumor cell eradication by photodynamic therapy.


text:
I have
W which is a 4 million row binary sparse matrix. I am using the Matrix package.
I would like to be able to compute the following:
W2 = W %*% W #W2 becomes a dgCMatrix
W2@x[ W2@x > 1 ] = 1
W2@x[ W2@x < 0 ] = 0
Unfortunately the third line in this operation trashes my computer completely. I am able to compute lines (1) and (2) just fine, but when I try to compute line (3) R demands much more RAM than I have available. I am sure that
W2 - W is "more sparse" than
W2 alone.
Is there any algorithm in vector form that allows to zero the positions of
W2 which are 1 in
W? Is there any efficient way to implement this in R?


text:
Breakfast Recipes (Most Popular)
A low calorie, low fat yummy muffin with chunks of apple. These are really sweet so you may want to decrease the amount of Splenda.Submitted by JESSICCA723
A quick and easy on the go breakfast for those busy mornings.Submitted by TABBYKAT75
Submitted by SHANFANNIN
Scones are perfect for weekend house guests, hostess gifts, or picnics. Traditionally made with loads of butter and cream, mine use far less butter--and wheat flour.Submitted by CHEF_MEG
Submitted by SOOKIE
Granola is incredibly affordable when you make it yourself. This recipe combines some of my favorite ingredients: maple syrup, almond butter and seeds!Submitted by STEPFANIER
From the kitchen of a golden arch fan. My healthy version of their breakfast sandwich.Submitted by 2BFREE2LIVE
I started making my own granola, and I wanted a recipe with no added fat.Submitted by STEPFANIER
These pumpkin chocolate chip muffins are a nice snack or treat when company comes over!Submitted by BLUERAY
Very Filling and Tasty. Great for Breakfast!Submitted by CAPATRIOT
Spinach and mozzarella cheese are baked together to make irresistable savory appetizer treats!Submitted by ERUPERTO
A lower fat version of our traditional Christmas Breakfast.Submitted by JOCYMC
High in fiber and low in fat-- a great way to start you day!Submitted by KARRI25
Light, fluffy eggs that can't be beat in six easy stepsSubmitted by ROSIET33
This simple, filling casserole is certain to be your new favorite breakfast. You can also turn it into mini muffins.Submitted by KAF61214
A simple pancake that is easy to prepare and to cook
Galettes keep for at least a week in the fridge but wrap them in foil or clingfilm so they do not dry out. Can also be frozen.
Submitted by CANDICEELAM
Fluffy, golden pancakes studded with juicy strawberries are the perfect addition to a spring breakfast or brunch. We like them with a side of crispy bacon.Submitted by CASE4GRACE
Very low calorie for a muffin and taste will have you making a double batch.Submitted by KIRBYU
Quick & easy egg muffins to make now and take later! South Beach - all phasesSubmitted by CODYJO
Great high protein breakfast! Fast and easy in the Microwave.
I love this as a quick dinner option too!
This make-ahead breakfast is perfect for busy mornings or Sunday brunches. And it has half the calories and 1/3 the fat of the original.
I came up with this simple, sweet, breakfast option because I couldn't face eggs every morning for breakfast. The cinnamon and splenda give the cottage cheese a wonderful, sweet flavor, and the chopped almonds give it a satisfying crunch.Submitted by NURSEHOPE
This recipe is awesome for breakfast on the run. One batch can be divided and last you the whole week!Submitted by ASHLEYINFL
This Southern staple gets a dose of fiber--with half of the fat of the original. Make a double batch over the weekend and freeze for the busy weekday mornings.Submitted by CHEF_MEG
Using applesauce instead of oil decreases the fat content of these muffins, but keeps them moist and sweet.Submitted by GAYENOBLE
This recipe makes really nice low cal/sugar free muffinsSubmitted by RACHELLEBEE
Healthy Oatmeal recipe that you prepare the night beforeSubmitted by KEBEST


text:
realmagick.com The shrine of knowledge.
Latex Pronunciation
A selection of articles related to latex pronunciation.
Original articles from our library related to the Latex Pronunciation. See Table of Contents for further available material (downloadable resources) on Latex Pronunciation.
- Who Were the Celts?
- The Celts were a group of people that occupied lands stretching from the British Isles to Galatia. The Celts had many dealings with other cultures that bordered the lands occupied by these people, and even though there is no written record of the Celts...
History & Anthropology >> Celtic & Irish
- Story of the Celts: Who are the Celts?
- The ancient Celts were a group of culturally similar peoples who once occupied most of central and western Europe, north of the Greco-Roman world. Perhaps the most common cultural characteristic of the ancient Celts were the Celtic languages, a branch of the...
History & Anthropology >> Celtic & Irish
- Meditation and Kaballah
- Meditation is one of the most vital elements of occult and esoteric practices, especially in the study of the Kaballah. I've heard it said that prayer is talking to the Divine and meditation is listening for the answers. I've also heard that the answers come...
Mind >> Meditation
- Meditation and Kaballah II
- Meditation is one of the most vital elements of occult and esoteric practices, especially in the study of the Kaballah. I've heard it said that prayer is talking to the Divine and meditation is listening for the answers. I've also heard that the answers come...
Mind >> Meditation
- Ehwaz
- The third rune of the third aett bears the reconstructed Common Germanic name Ehwaz. Later, its name became Aihws in Gothic (note how archaic Gothic is), and still later, Eh in Anglo-Saxon. If you remember that "k" in Indo-European changed to "h" in Germanic,...
Divination >> Rune Stones
Latex Pronunciation is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Latex Pronunciation books and related discussion.
Suggested Pdf Resources
- LATEX, concisely
- Preface xiii. 1 First examples. 1.
- www.cs.rhul.ac.uk
- The Kile Handbook
- 2.1.2 Kile and the Kate Editor Component .
- docs.kde.org
- The English documentation of the package engpron
- enable us to write the British or American English pronunciation as one can This package loads tipa, with which one can write with the API 1 through LATEX.
- ctan.mackichan.com
- Pronunciation Modeling for Improved Spelling Correction
- misspelling often has the same pronunciation as the correct word ( for example writing latex as latecks).
- aclweb.org
- Introduction to the LaTeX Document Preparation System
- the few things I'm not going to tell you about LaTeX, since pronunciation is best determined by usage, not fiat.
- lists.bilkent.edu.tr
Suggested Web Resources
- LaTeX - Wikipedia, the free encyclopedia
- en.wikipedia.org
- LyX wiki | FAQ / Pronunciation
- § LaTeX.
- wiki.lyx.org
- How do you pronounce LaTeX?
- How do you pronounce LaTeX?
- www.urch.com
- What is(are) the proper pronunciation(s) of LaTeX? - Quora
- "Lah-tech" or "Lay-tech" Source: http://en.wikibooks.org/wiki/LaT...
- www.quora.com
- tex general - What is the correct pronunciation of TeX and LaTeX
- May 5, 2011 This is also one of the few things I'm not going to tell you about LaTeX, since pronunciation is best determined by usage, not fiat.
- tex.stackexchange.com
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
Latex Pronunciation Topics
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text:
The Blueberry Muffin is a computing dream come true, and at £450 it's an absolute bargain too. It's sure to fly off the shelves. Infinitely upgradeable yet immensely portable, it can be put to any task you desire. Quite simply, place your order for yours right now, because revolutionary products like this don't arrive more than once in a million years.
You have exceeded your hourly limit of requests
Trusted Reviews is part of the Time Inc. (UK) Ltd Technology Network


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The Way is a story about family, friends, and the challenges we face while navigating this ever changing and complicated world. Tom, an irascible American doctor, comes to St. Jean Pied de Port, France to collect the remains of his adult son, killed in the Pyrenees in a storm while walking The Camino de Santiago, also known as The Way of Saint James. Rather than return home, Tom decides embark on the historical pilgrimage to honor his son's desire to finish the journey. What Tom doesn't plan on, is the profound impact the journey will have on him and his "California Bubble Life". Inexperienced as a trekker, Tom soon discovers that he will not be alone on this journey.
|Rotten Tomatoes
82% - Certified Fresh
83% - Upright
Movie Details
|Domestic Releases:
|October 7th, 2011 (Limited) by Producers Distribution Agency
|International Releases:
|April 26th, 2012 (Wide) (Australia)
April 26th, 2012 (Wide) (New Zealand)
June 21st, 2012 (Wide) (Germany)
June 27th, 2012 (Wide) (Italy)
July 5th, 2012 (Wide) (Argentina)
... Show all releases
|Video Release:
|February 21st, 2012 by ARC Entertainment Video
|MPAA Rating:
|PG-13 for some thematic elements, drug use and smoking.
(Rating bulletin 2145, 11/3/2010)
|Running Time:
|115 minutes
|Create your own comparison chart…
|Health & Fitness, Writing and Writers, Relationships Gone Wrong, Road Trip, Death of a Son or Daughter, Religious, Relatives Playing Relatives
|Production Method:
|Live Action
|Creative Type:
|Contemporary Fiction
|Production Countries:
United States


text:
Q: What Should I do for my kitty's birthday?
Attention all cat lovers!!!
I love my kitty very much, and I know some peole might think i'm crazy, but I would like to do something for her first birthday. My question is simple, What should I do? I know Zootoo is only going to pick one answer to my question, but i would like more of a selection, for those of you who would like your answer to my question heard, my e-mail address is: email@example.com. All responses welcome!
Mar 14, 2008
You are not crazy for wanting to do something special for your kitty. They are a member of the family and should be treated as one! I always celebrate holidays and birthdays by giving my cats a special dinner (their usual with a little extra and some fav. cat treats hidden in it) and a new toy or six. I tend to over do it. I try to make the day special with the food since that's what they seem to love the best. Kitty nip and lots of play go a long way too. (even though I do that all the time) I like to sneak the special kitty away from the others and give them their own birthday treat that the others won't know about.
Thumbs Up: 1 | Thumbs up!
Mar 15, 2008
Additional response to my answer below:
After a couple years of celebrating your kitty's birthday, your kitty will have accumulated enough toys and have all the essentials. You can still celebrate the birthdays with extra playtime and one-on-one attention, but why not start HONORING your cat's birthday by donating to your local shelter? You can either donate money and/or some toys and enclose a card stating "In Honor of ______ [your cat's name]". This will make your kitty's birthday extra special by knowing that you helped homeless animals who are less fortunate.
Thumbs Up: 1 | Thumbs up!
Mar 19, 2008
You could throw them a kitty party = make your cat the center of EVERYONES attention and obviously you can have some time wiht your friedns too.. if your cat loves play mates then you can have them bring their cats over for play time... maybe everyone bring a toy and they can have a huge play fest & snuggle fest... (YOUR CAT CAN NEVER HAVE TOO MANY TOYS) also maybe make a cat friendly cake (im sure there are recipes on line) get a big treat bowl so your cat can fill himself/herself with lots of treats...
happy birthday kitty kat
Thumbs Up: 0 | Thumbs up!
Got a question about your pet? Get the answers you need from Zootoo's community of pet experts and owners.


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My review
Original recipe yields 8 servings
Based on a 2,000 calorie dietSee full nutrition
Ready In
I made this carrot cake for Easter Sunday and it was my first carrot cake I have ever made and my husband loves carrot cake and he loved this cake I added a cream cheese frosting but the cake wa...
Moist carrot cake. I cut the sugar in half and used half oil half apple sauce. Would be great with cream cheese icing. If making it again I would add more cinnamon.
Follow this recipe exactly for perfect baking results. So moist and just sweet enough with a thin cream cheese frosting of your choice.
Nice and moist... I use self raising flour instead of AP flour, therefore did not use baking powder and baking soda. I have reduce the sugar. I use 1cup of caster sugar and half cup of brown s...


text:
/ News
ONE of the UK's leading lingerie brands has announced plans to open a concession store in Glasgow.
The retail part-nership will see Ultimo open an initial two outlets at House of Fraser stores in Glas-gow and Manchester next month.
The brand specialises in fashion lingerie as well as bridal and swim-wear, and will be staffed by specially trained Ultimo consultants.
The current 'face and body' of Ultimo is model Abbey Clancy, who will front the brand's forthcoming Autumn Winter campaign.
Michelle Mone OBE, founder of Ultimo, said: "We are hugely excited about increasing our presence in House of Fraser stores and making Ultimo more widely available on the UK high street.
"Our growth strategy is focused on three key areas: growing store presence, increasing our product offering and online expansion.
"With these new stores, we will be in a position to showcase Ultimo's full product offering, while also giving consumers a seamless Ultimo shopping experience."
The new stores will be designed by global retail design agency Design4Retail, which has previously designed retail solutions for brands including Cath Kidston, Clarins, Clinique and Adidas.
A House of Fraser spokesman said: "Ultimo is an iconic lingerie brand.
"We know that our customers will be delighted the brand is more widely available in our stores."
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french lesson in Greenville, OH
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text:
University of Redlands > Academics >
School of Music >
Special Events and Performances >
Wind Conducting Conference
Fourth Annual Conductors Conference
March 17 – 20, 2016
This is a four-day intensive session designed for teachers and conductors at all levels. We will explore the Art of Conducting and the Art of Teaching, working to help everyone improve their skills and understanding in a positive learning environment. The conference will be led by Dr. Eddie Smith, professor of music and director of bands at the University of Redlands. Guest clinicians are Dr. Russel Mikkelson, Ohio State University, and Dr. Gary Hill, Arizona State University.
$300 for conducting participants (accepted on a first-come, first-served basis)
$175 for observers
Registration form (pdf)
Russel Mikkelson - Ohio State University
Gary Hill - Arizona State University
Eddie R. Smith - University of Redlands, Director of Bands/Assistant Dean
Conference Repertoire:
University of Redlands Wind Ensemble (possible changes)
An Outdoor Overture by Aaron Copland
Marching Song by Gustav Holst
Kentucky 1800 by Clare Grundman
Variants on a Medieval Tune by Norman Dello Joio
Colonial Song by Percy Grainger
Hammersmith by Gustav Holst
Fanfares from the Opera Libuse Smetana/Nelhybel
Sketches on a Tudor Psalm by Fisher Tull
Symphony in Bb by Paul Hindemith
University of Redlands Chamber Winds Ensemble (U of R Faculty)
Septet by Paul Hindemith
Serenade in Eb, Op. 7 by Richard Strauss
Petite Symphony by Charles Gounod
Scores are available from Midwest Sheet Music
Phone: 314-291-4686
Fax: 314-291-4166
In April 2010, it was designated a Tree Campus USA by the Arbor Day Foundation. Redlands is among just three other colleges or universities in California to receive this designation.
© 2016 University of Redlands. All Rights Reserved.


text:
- 245Promote
Thirty Fiveby Fresh Doodle - JP Valderrama
Available in 11 and 15 ounce sizes, our premium ceramic coffee mugs feature wrap-around art and large handles for easy gripping. Dishwasher and microwave safe, these cool coffee mugs will be your new favorite way to consume hot or cold beverages.
For all basketball fans I'm pretty sure you know who this is, yes it's Kevin Durant of Oklahoma City Thunder. By the way this guy plays, there no doubt he's been gaining fans everyday and that includes me. I just love how he plays especially on moments that count! Go OKC! 1-0!
Also, if you haven't noticed I kinda mixed up my technique here and did it differently. Let me know if it's still Absolutely Doodle-cious! ^_^
Absolutely Doodle-icious!
Website - http://www.freshdoodle.com
Twitter! - http://twitter.com/thefreshdoodle
Facebook - http://www.facebook.com/freshdoodle
Tumblr - http://freshdoodle.tumblr.com
Shadowness! - http://www.shadowness.com/thefreshdoodle
Behance - http://www.behance.net/freshdoodle


text:
To make reservations by phone, dial freephone 0800 221 222 in the UK, 1 800 409 929 in Ireland, or view our regional telephone reservation numbers.
Courtyard Flagstaff
2650 South Beulah Boulevard
Flagstaff, Arizona 86001 USA
Flagstaff Pulliam Airport - FLG
Airport Phone: +1 928 556 1234
Hotel direction: 6.8 km N
Follow AZ-89A north for four miles to the hotel
Phoenix Sky Harbor International Airport - PHX
Airport Phone: +1 602 273 3300
Hotel direction: 236.6 km N
This hotel does not provide shuttle service.
Take Interstate 17 North approximately 145 miles to the Airport Road/AZ-89/Fairgrounds Road West exit in Flagstaff. Turn right onto AZ-89A/Beulah Boulevard and proceed north to the hotel.
Prescott Municipal Airport - PRC
Airport Phone: +1 928 777 1114
Hotel direction: 151 km NE
This hotel does not provide shuttle service.
For more information call the general manager of the hotel


text:
WASHINGTON – When it comes to Washington's taste in diamonds, the region is tapping into the national conscience.
"Their tastes are exactly on par with the national preference which is round cut diamonds, generally colorless and high-clarity grades of round cut," says Josh Holland of the diamond outfitter Blue Nile. "This is the most frequent choice of Washingtonians."
The average cost for a ring is $4,000 and the best place to propose is the Tidal Basin at the peak of the cherry blossom season. When all else fails, Blue Nile says the Washington Monument is also hard to beat.
The Bluenile.com website includes a photo gallery of engagement rings recently purchased in Washington, D.C.
Follow WTOP on Twitter.
A look at winter weather news from around the D.C. area.
From Rhett & Scarlett to Harry & Sally, who are the most romantic movie couples?


text:
Announcing Cotton Spandex Jersey!
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One of the most solemn articles of NBA faith is that the key to any playoff series is "adjustment", or, in non-technical terms, what changes the loser of the previous game can make to turn things around.
So what "adjustments" did Coach Alvan and the Suns make to engineer a monster 34-point turnaround in Game Two?
Actually, while not discounting the significance of a couple of X and O moves, I'd have to say the biggest adjustment was an attitude. One in which the Suns went from passive-aggressive on offense to aggressive-aggressive.
The biggest benefit of this was that the Blazers didn't have nearly as many chances to get into the half court defense that so effectively dictated the tempo in Game One. This time the Suns' offense dictated the tempo, and when that happens very few teams can hang with them — especially since they've added solid defense to their repertoire.
As far as physical adjustments, the biggest one was putting Grant Hill on Andre Miller, a move that not only worked well defensively, but also freed up Jason Richardson at the other end, and J.R. responded with 29 points, 15 in the first period when the Suns were doing all the all-important tempo-setting that put them back on course.
The 37-year-old Hill, whose multiple talents are much underappreciated, can handle almost any role at either end of the court, and last night he not only played a key role in holding Miller, who torched the Suns for 31 Sunday, to 12, but also hit his first 10 shots. And 36-year-old Steve Nash had 16 assists in 29 minutes.
You go, Geezers!
"Miller is very difficult to guard," said Alvan, "and we thought Grant's length might bother him a little bit. We played him a step back and tried to make him settle for outside shots, but his first step is so good he still managed to get to the basket a few times."
The Suns also dominated the boards, held the Blazers to 38 per cent shooting, and got 18 points and some good pass work out of the post from Amare Stoudemire.
So what does this rout change in the grand scheme of things. Well, one thing it DOESN'T change is the fact the Blazers are still up a break as the series shifts to Portland for the next two games.
But it does underscore just how many more weapons the Suns have, and how many more ways they have to beat you than have the injury-depleted Blazers (who may have lost yet another starter when Nicolas Batum left the game with a shoulder injury in the third period).
I'm not a big believer in momentum, but I do have a lot of faith in a talent edge, especially when it's blended into the kind of chemistry and sense of mission these Suns clearly have.
The bottom line: I still liked their chances a ton after Game One, and I certainly didn't see anything to change my mind last night. And I don't mean just in this series.