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I have chronic back and leg pain from arthritis(I guess) and inflamation, also from a small herniated disc(l-4,l-5) Also hip pain and stiffness that prevents me from walking normally almost 80% of the time, particularly if I've been sitting for more than a few minutes.I've had steroid injections that relieve the hip pain temporarily. I have used large doses of ibuprofen, aspirin and/or tylenol with almost NO result. Even Lortab does not resolve my pain completely. I recently tried Doan's just for the heck of it, and I seriously though I must have died in my sleep, as I woke up virtually pain free with just one dose. Is it more likely to cause kidney and liver damage than ibuprofen?? Can you take it every day??
How or why does this drug work so well when others haven't for me?
- Posted:
- 30 May 2010 by letmbuck
- Topics:
- pain, magnesium salicylate, herniated disc
Answers (1)
1 Jun 2010
I do not know what they contain (well actually I see they have paracetamol and sodium salicylate but am no sure what those are. What I do know is that everyone is very very different when it comes to pain management. The thing that works for me may not work for you and vice versa. You are very lucky to have found something that is so easily obtained and has very few side effects. Side effects mar the situation so easily. Congratulations! I think you can find a lot of information on Doans on the internet.
What is doans is it like a asprin or is it like a vitamin supplement I never heard of that
Further Information
- Magnesium Salicylate Information for Consumers
- Magnesium Salicylate Information for Healthcare Professionals (includes dosage details)
- Side Effects of Magnesium Salicylate (detailed)
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Do you love insurance?
However you answered that, you can still Dress Like Flo for Halloween.
You can also learn to Talk Like Flo, by downloading an app for your phone.
Do you love insurance?
However you answered that, you can still Dress Like Flo for Halloween.
You can also learn to Talk Like Flo, by downloading an app for your phone.
Native Nebraskan in the Pacific Northwest. Chief Storyteller at Bonehook, a guide service and bait shop for brands. Co-founder and editor of AdPulp. Contributor to The Content Strategist. Doer of the things written about herein.
Ah holidays, always a great way to get a little extra advertising kick. Very smart, Progressive. I don't think I would recognize someone "dressed up as Flo" but you never know. Seems like another example of how advertisers are attempting to enter into our daily lives, by subtly, and sometimes not so subtly, sending messages that go beyond TV and newspaper ads. Halloween costumes, what a great way to get others to do the advertising work for you, and to have your advertisement walk around, for free, in the social world.
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George Humperdink Hamilton (born August 12, 1939) is an American film and television actor. He has been nominated for a Golden Globe for his performances in Love at First Bite (1979) and Zorro, The Gay Blade (1981).
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More fleshed-out details surface for upcoming Kindle Fire models
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Motorola will not only introduce the world to the Moto X on August 1 but it may also begin selling the device on the same day. At least that's the
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So I was thinking it would be fun to hear everyone's favorite comments/advice/whatever that they've received about pregnancy or parenting so far.
Here are mine:
The other day I was emptying the dishwasher and my husband said, "Wow, you're starting to get mom-ass!" I turned around very slowly and just looked at him. He started babbling something like, "I meant it as a good thing! Like it's... you know... wider. Wait, I mean like... bigg- no, rounder and... um." He then wisely shut his mouth and walked out of the room. I know he loves my body but I love to hear him stick his foot in his mouth when he tries to compliment it :)
DH also said he'd miss me being pregnant because I "get even more beautiful".


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Take my destiny by saturnspaceWatch
©2013-2016 saturnspace
voter choose of clockwise vision of applejack
I wanna make it little bit different so ....well apple is the fruit of fate hmmm
I wanna make it little bit different so ....well apple is the fruit of fate hmmm
She looks so beautiful!!!
Looks great!
Very pretty!
Well done on this! She's beautiful and what's with the writing...? Below on the right?
This does look good!
As for the writing, multiple languages, obviously, as with the English on it, translate to "Fate" or maybe "destiny" because of the title.
Applejack looks sweet with that little smile
Awesome design!
Gorgeous! I love it so much!
What is this style of dressing called? I've seen it around, but never understood the reference......
hehe she looks so cute in that out fit
That makes me think of that one line from the song "I Am The Wind" by Cynthia Harrell.
"I face my destiny every day I live
And the best of me is all I have to give"
This is adorable! I live AJ so much!
AJ looks great and cute here.
"судьба", "доля". На других языках то же самое написано? Увидел латинское "destino", и английское "fate".
cool dude XD maybe next time you can do a Dusk shine XD
its so bootifull
I'd rather take her virtue.
AAAAAAAH! Adorable! That's why I voted for her! ^_^
timelord AJ<?wowcutey!
Hehe, I see "soarta" is in there too. Nice!
SO AWESOME costume!
saw this on eqd and just KNEW it to be yours! great job! love ya art
Nice costume! I see that even Rarity would be pleased about this country touch for this fashion set!
Beautiful! <3
lmao, when i saw 'судьба' and 'доля' i though you're russian, hue
great art anyway
great art anyway
The coloring and details are amazing! Very impressive !!
she looks utterly adorable <3
Oh my god she is so adorable *_*
A fine work of art, but the pose makes me click "favorite" with a high degree of reluctance...
What if you killed her to take her destiny? would her destiny become death by you?
This is a wonderful piece of art!
Sweet pic
*Explodes into rainbow sprinkles*
her legs look like theyre bending the wrong way, but looks awesome overall.
cool ^^
I was saying in my head that "Wow, this is great! I'm going to watch this Deviant," only to find out that I already am watching you. I have had that happen multiple times. =3
nice style but I dont like the motive
like the detail on the outfit, gj!
May I use this if I give you credit?
She's beautiful!
I was waiting for you to draw Applejack. I was unsure of how she would appear in your steampunk universe.
That is the most ornate stetson I have ever seen.
I love this
Awesome!!! >w<


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Need tips on flying with toddlers! HELP
Harper Liam 01/22/11
Beckett Luther 1/10/14
Wren Ivy due 4/27/16!!
I've been flying with my 2 1/2 year old since he was 5 weeks. Its different everytime,
FIRST I would invest in a seat for him, it will make your life much easier
SECOND, how long until you go? He is old enough to start potty training and even if you get a couple "on the potty" pee pee's or poo poo's at the airport or on the airplane, it will be nice not to have to change diapers. An upcomeng trip prompted us to begin potty training at 14 months, he was completely in undies by 18 months so it is possible!
THIRD bring plenty of toys, snack and entertainment, bring a sippy for him that kind of makes him suck as this and the swallowing will help relieve pressure in his ears.
LASTLY, I think he will do better than you think. Start pointing out airplanes when you see them and talk about the fact that you get to go on one soon, and it will be SO FUN and you will be going somewhere SO AWESOME! If not by this trip, by the next he will be super excited :)
Kids fly safe CARES is a great product. They are straps that lock into the seatbelt and act like a car seat to minimize moving around (if he has his own seat)
Bring things he likes : coloring books, iPhone/iPad toddler apps are great, magnet, books, a favorite blanket.
I usually spend a bit more to fly the mid afternoon flights so we can eat in the plane then nap. My son does not do well in late evenings... But others do great.
You can bring food. I get away with larger liquids (juice, milk box) with MOST TSA reps.
All bathrooms have infant changing tables.
Sitting in the back of the plane is usually where most families sit and my new favorite spot.
Above all, if there happen to be bad moments just know that you will think it's worse than it really is. Most people are so nice and understanding and realize you weren't coaching your child to cry durin the flight... ;-)
Good luck!
Baby Boy #1 ~ 03.24.2009
Baby Boy #2 ~ 01.29.2013
Baby Girl #1 ~ 06.11.2015
I was very nervous when I flew with my daughter for the first time, but she did great (she was about the same age as your son at that time)! Don't stress too much, I'm sure he will do just fine.
Christen & Josh {7/2006}
Madeline {9/2006}
Lillian {1/2013}
All bathrooms have infant changing tables.
^^^ This is incorrect... we have been on several cross country flights and smaller planes that do NOT have change tables in the lavs... particularly the United Airlines flights and some American Airlines flights.
My suggestion, get used to changing a diaper while LO is standing up... and yes this includes poopy diapers. Practice at home. This will also come in handy when you can't find a change table in a public bathroom (like in the united wing in Washington DC ~ NO FREAKING TABLES in there).


text: I wanna thank Diana for this beautiful vacation , she send e-mails in advance and there she was an amazing person who took care for our vacation , made breakfast , giving instructions . The apartment is a nice one . The room we booked had wifi , bathroom , window and having breakfast in the morning with the best... More


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86310 by aleksandra88Watch
©2011-2016 aleksandra88
she looks like beautiful moss attached to the tree.
as a dandelion seed head caught on a tree ♥
lovely picture, amazing series...
Wow ...stunning photo
gorgeous image!
I adore how you have a style and technique all your own; I know immediately when you upload something, and I love it all; absolutely incredible. I strive to be as talented as you. :
amazing pic....
*wants that dress!*
This is stunning!
lovely image..
Absolutely amazing!
This series is wonderful!


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my first s.t.a.l.k.e.r theme desing hope u like it !!!
I prefer this out of your 3 "true stalker" designs. The monochrome palette is most effective in conveying the grimness of the setting. The background gives the picture amazing energy, as you realise that the Stalker is not standing awkwardly - it captures the recoil, at the moment after firing.
Wow! Cool! Great work!


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Pride and Prejudice and Zombies
The small, deadpan moments in "Pride and Prejudice and Zombies" have more of an impact than the massive, noisy set pieces.
The small, deadpan moments in "Pride and Prejudice and Zombies" have more of an impact than the massive, noisy set pieces.
The Choice totally botches its central pairing, to the point where you might find yourself hoping the blandly irksome twosome fail to even get together.
"The Ballad of Narayama" is a Japanese film of great beauty and elegant artifice, telling a story of startling cruelty. What a space it opens…
Patrice Leconte's "Monsieur Hire" is a tragedy about loneliness and erotomania, told about two solitary people who have nothing else in common. It involves a…
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An article about "Star Wars" fashion.
An article about Laurie Anderson's "Heart of a Dog."
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I'm not sure I could pass a test on the plot of "Mission: Impossible." My consolation is that the screenwriters probably couldn't, either. The story is a nearly impenetrable labyrinth of post-Cold War double-dealing, but the details hardly matter; it's all a set-up for sensational chase sequences and a delicate computer theft operation, intercut with that most reliable of spy movie standbys, the midnight rendezvous under a street lamp in a chilly foreign capital.
Tom Cruise stars as Ethan Hunt, professional spy, whose assignment, which he chooses to accept, is to prevent the theft of a computer file containing the code names and real identities of all of America's double agents. It's not enough to simply stop the guy; Cruise and his team (also including Jon Voight, Kristen Scott-Thomas and Emmanuelle Beart) are asked to photograph the enemy in the act of stealing the information, and then follow him until he passes it along. This process involves a check list of Cold War spycraft and cliches: Eye glasses with built-in TV cameras, concealed microphones, laptop computers, agents in elaborate disguise, exploding cars, knifings, shootings, bodies toppling into a river, etc. Of course the whole sequence centers around a diplomatic reception in Prague.
Because "Mission: Impossible" was directed by Brian De Palma, a master of genre thrillers and sly Hitchcockian wit ("Blow Out," "Body Double"), it's a nearly impossible mission to take the plot seriously.
He is more concerned with style than story, which is wise, since if this movie ever paused to explain itself it would take a very long time.
There are so many double-reverses in the first half hour that we learn to accept nothing at face value (not even faces, since they may be elaborate latex masks). And the momentum of the visuals prevents us from asking logical questions, such as, is physically copying a computer file onto another disc the only way to steal it? (My colleague Rich Elias has written that the obvious solution for the CIA would have been to hire Robert Redford's team from "Sneakers" to commit an online theft.) "Mission: Impossible" is all slick surface and technical skill. The characters are not very interesting (except for Vanessa Redgrave, as an information broker, and Jon Voight, who expresses a touching world-weariness in a film too impatient for weariness of any kind). The plot is impossible to follow. The various strategies of Cruise and his allies and foes don't stand up under scrutiny. And none of that matters.
This is a movie that exists in the instant, and we must exist in the instant to enjoy it. Any troubling questions from earlier in the film must be firmly repressed.
De Palma is expert at sustained nonverbal action sequences, and there are three in the film: The opening scenario at the diplomatic reception; a delicate act of computer theft; and a chase in which a helicopter follows the high-speed London-Paris train into the Chunnel with Cruise and a bad guy clinging to the top of it.
The computer theft scene will ring a bell with anyone who has seen "Rififi" (1954) or "Topkapi" (1964), both by Jules Dassin, who became famous for his extended theft sequences done in total silence. "Topkapi" also used the device of suspending a thief from a hole in the ceiling, to avoid anti-theft devices on the floor. This time, De Palma gives us a computer "safe room" rigged so that alarms will sound at any noise above a certain decibel level, any pressure on the floor, any change in temperature. Cruise hangs in a harness while carefully inserting a blank disc and making a copy of the file.
Of course it's convenient that the decibel level is set high enough that it isn't triggered by the noise of a computer copying a disc -- which is precisely what it should be guarding against. Convenient, too, that the infra-red rays guarding the ceiling hatch can be so conveniently dealt with. And very convenient for the audience that the rays are made visible to a normal eye. If you want to see infra-red rays -- really -- exploited in a heist movie, have a look at "Grand Slam"(1968).
If the heist has been done before, and better, not even the James Bond films have ever given us anything quite like the ending chase sequence, with a bad guy in a helicopter flying into the Chunnel linking Britain to France. Earlier it's been established that the train through Britain is traveling so fast that Cruise, clinging to it, might easily be blown off. This will cheer the film's British viewers, who can forget for a moment that the Chunnel train goes that fast only on the French side, since the high-speed tracks on the British side have not yet been completed. (Inaugurating the Chunnel, Francois Mitter and wickedly described a traveler "Speeding through France and then enjoying a leisurely view of the British countryside").
No matter. The train goes fast, and the helicopter follows it right under the Channel, and De Palma's special effects (by Industrial Light and Magic) are clever for obscuring the scale involved, since a helicopter's blades would obviously not fit into the tunnel -- but then why am I quibbling, since the whole stunt is obviously impossible?
The bottom line on a film like this is, Tom Cruise looks cool and holds our attention while doing neat things that we don't quite understand -- doing them so quickly and with so much style that we put our questions on hold, and go with the flow. When the movie is over, it turns out there wasn't anything except the flow. Our consolation, I guess, is that we had fun going with it.
This message came to me from a reader named Peter Svensland. He and a fr...
The latest Unloved looks back at David Bowie and Julien Temple's 1986 collaboration.
FFC Gerardo Valero considers the flaws within "Star Wars: Episode VII - The Force Awakens."
With "The Hateful Eight," Quentin Tarantino betrays the female fans he's until-now supported.


text:
Three Suspected PSN Hackers Arrested In Spain
Spanish police apprehended three "Anonymous members," alleged to have been involved in April's PSN breach, attacks on the governments of Libya, Iran, Egypt, Algeria, Colombia Chile, and New Zealand, as well as some banks. A server seized from the home of one suspect's home is believed to have been used for the attacks, though the extent to which is was involved is not immediately clear. The group roused the interest of the Spanish government last year, when the website of Spain's Ministry of Culture fell victim to a DDoS attack in response to the government's then-recent anti-piracy legislation. According to cnet:
Police say their raids turned up software used to make malware and sophisticated encryption tools, as well as a program called LOIC, which the hackers used to carry out DDoS campaigns. Via their Twitter feed, police also posted the below screen capture from an IRC (Internet Relay Chat) room, which they claim shows the group's targets.
The suspects have left police custody without bail, and charges are expected to be filed sometime in the near future. 1up reports that successful prosecution for the presumptive charge, "forming an illegal association to attack public and corporate Web sites," could earn the alleged hackers in upwards of three years in prison. In a vaguely humorous twist, Anonnews.org, the main hub for Anonymous's press releases, is currently down, due to a DDoS attack.
Read my thoughts on the recent news after the jump!
So far, there is no evidence to suggest that the three individuals, even if they were part of Anonymous, had the blessing of the group's top leadership - assuming it even exists. Actions such as the PSN breach fly in the face of Anonymous's stated goals: striking at a corporation that brought legal action against a man who, in Anonymous's view, did nothing wrong. Moreover, it's just senseless. Granted, the whole debacle arguably showed Sony's impotence in the face of hackers, owing to a security apparatus that was clearly unable to withstand such an attack, and it did indeed bring the company under a good deal of fire from consumers who felt that Sony handled the situation quite poorly - dare I say, in a rather "corporate" manner. That does not, however, deflect blame from those behind the breach, causing a massive inconvenience for gamers, and ultimately, terrible PR for the parties involved. As I've mentioned in previous articles, Anonymous has nothing to gain, and everything to lose, from such an attack - assuming, of course, that they are not stupid beyond comprehension. There could easily be members falling into the aforementioned camp, but to label those who fly under the banner of Anonymous as being representative of the group is silly, simplistic, and rather unhelpful.
If the suspects are in fact proven complicit in the attack, then good for the Spanish police. The whole PSN episode was profoundly annoying, and I'd be happy to see the perpetrators get their due. What constitutes "top leadership" is up to interpretation; Anonymous's pubic persona is that of a decentralized, grassroots, quasi-vigilante collective, rather than a rigidly stratified organization. In any event, despite the arrests, I doubt it will make much of a dent. As long as there are computer-savvy people there will be hackers, and as long as some of these people find themselves angry about a particular issue, there will be "hacktivists."
Via cnet


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Host Paul Van Dyck speaks with Clark County Sheriff Phillip Sample about Operation Life Saver which aims to locate and rescue missing persons. Later Paul speaks with Dr. Harold Ellner, a retired urologist from Richland, Washington who writes about medical humor.
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text: One of the exciting projects we're working on here at seOverflow is to update our site audit and ongoing SEO task lists. The attrition rate of old tasks isn't anywhere near the growth rate of new tasks, so while the list has been evolving it has also been growing. Our new audit task list has tripled in length from the one I had a few years ago. Continue Reading


text:
This image released by Calvin Klein Collection shows, from left, Anna Wintour, Virginia Smith, Nicole Kidman, Rooney Mara, and Naomie Harris at the Calvin Klein Spring 2014 collection during Fashion Week in New York on Thursday, Sept. 12, 2013. (AP Photo/Calvin Klein Collection, Billy Farrell)
NEW YORK (AP) — Nicole Kidman says she was shaken up after being knocked down by a bicyclist on a city sidewalk.
Kidman appeared on the red carpet Thursday night celebrating Francisco Costa's 10th anniversary as the women's creative director of the Calvin Klein Collection.
Earlier, the 46-year-old actress was outside a hotel when she was hit by a bicyclist. She was knocked to the ground, but in an interview with The Associated Press at the Calvin Klein event, she said she was OK.
Kidman added: "I'm up, I'm walking around, but I was shaken."
The New York Police Department says a 19-year-old bicyclist was issued three summonses for riding a bike on the sidewalk, riding a bike with no helmet and reckless endangerment.
Associated Press
Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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How Baraga, MI Watches TV
The CableTV.com team loves seeing how national trends relate to TV use in Baraga, MI. For instance, 97% of the population tunes in to traditional television, even though 1/2 of Americans watch at least one program online every week. In addition to that, 1/3 of homes in America have 4 or more televisions. Almost three-quarters of U.S. residents with cable bundle their TV service with high-speed Internet. For Baraga's population of 1,260, that's equal to:
- 416 with 4 or more TVs
- 605 using Hulu or Netflix to stream content
- 907 viewers with cable bundles
- 1,046 people in Baraga stuck watching TV on the networks' timeline.


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Ally McCoist said Rangers would have liked to sign Ryan McGowan
/ Sport
RANGERS boss Ally McCoist has admitted he will continue to monitor the progress of Ryan McGowan – despite the Hearts defender moving to China.
Australian international McGowan, below, who the Gers tried to sign back in August, has agreed a lucrative deal with Shandong Luneng.
But McCoist is a huge admirer of the right-back and will keep tabs on how the 23-year-old performs in Asia in the months ahead. He said: "I don't know the exact ins and outs of his contract (with Shandong), but Ryan is a player we certainly would have liked to have brought here. He'd have been a good one for us.
"I can't predict the future. I don't know how Ryan will do or what our situation will be. But you'd have to say he was a player we were interested in so we'll continue to monitor him and wish him all the best."
Rangers have started to speak to players who are free agents in the summer and McCoist revealed he has been "encouraged" by the response. The Ibrox club can, despite a 12-month transfer ban, speak to individuals who are out of contract in the summer and then register them as players on September 1.
He said: "We've been encouraged by the interest that's been shown from one or two players we've been monitoring.
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"The great thing is that the support, the stadium and the training ground is still a big pull for some players.
"We've got endless lists of players whose contracts are up at the end of the season. We're definitely looking now.
"If there's an opportunity to do it now or plan for the future then we should be doing it now and we are."
Meanwhile, McCoist has revealed Darren Cole may have to undergo surgery on the ankle injury he sustained against Annan in midweek.
The right-back, who turned 20 on Thursday, was stretchered off in the second half of the 3-1 win at Galabank in what was his second start for the Ibrox club.
McCoist said: "Darren has a bad one. The swelling is way up and I'm not too hopeful. We think he'll need an operation."
There was, however, good news for McCoist ahead of the Irn-Bru Third Division match against Elgin City at Ibrox this afternoon.
Emilson Cribari, Lewis Macleod, Lee McCulloch and Dean Shiels are all available again after injury and should come back into the side.
Elsewhere, Kal Naismith, who had been sidelined with an injury, trained yesterday but will not be in the squad.
McCoist confirmed any new arrivals will not hamper the progress of the kids who have broken into the first team.
He said: "It would be totally wrong of me to spend and bring in players that would be to the detriment of the youngsters.
"You have to get the balance right and it has to be to the benefit of the club and the team, that's an absolute must.
"But at the same time you have to be very careful to help the youngsters as well so they can continue to blossom."
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PyleHome 5.25" Two-Way In-Wall Speaker System (Pair)
The Pyle PDIW55 speaker system delivers stereo sound to any room in your home or office without cluttering floor space. This pair of 5.25" speakers can be used for in-wall and in-ceiling applications as they mount flush for a clean look. Perfect for custom installations, the PDIW series speakers feature impressive power handling capability, high-temperature voice coils and high-efficiency response rates – all to produce more full and rich sound. Convenient speaker terminals allow for quick and hassle-free speaker wire connection. System includes cut-out template for easy installation. Achieve wide-ranged sound performance and add audio to any room with the PDIW Speaker Systems.


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Is this motion blur or a bad focus point?
Started Feb 12, 2012 | Discussions thread
Shop cameras & lenses ▾
CaseySRT wrote:
I tried to focus on his left eye. Hand held, no post processing. To me it looks like his eye is out of focus but the hair in his ear is sharp. Did I just miss my focus point when I pressed the shutter button?
Maybe he blinked.
Are you sure the lit focus point was dead on the cat's eye. Just want to make sure. Do you have any other shots with the same thing or is the a one out type issue?
-- hide signature --
Cheers, Craig
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iHerb カスタマーレビュー
The best Omega 3 I have tried
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The small capsules are concentrated and easy to swallow, without causing the burping effect of other Omega 3s. The delivery time was excellent too. Thanks Iherb.
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really like this product to use with other omegas
Krill, Omega-3
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My husband and I both take this supplement. The review on this one was very helpful.


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How long did it take you to lose all your baby weight?
I was 160 (I'm 5'7ish) before I got pregnant. I gained 80lbs altogether. It was alot, I know.... but I took it all off within 10 months and now I'm back to what I was............
Started by Katherine on 03/31/2009 in Welcome To Circle Of Moms!!
Last update on 01/09/2012 by Miri


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Li-Ming is a powerhouse in Heroes of the Storm, but not overly so
Jan 27
// Chris Carter
[embed]337067:62020:0[/embed] I took her for a spin in PTR this week, and I have to say I'm impressed. Her magic missile ability is really fun to aim, as it alters its skillshot path depending on the amount of heroes present. It allows for a unique kill potential that a lot of players won't be expecting when she's fresh on the roster. Her Arcane Orb is also really fun to use, especially on objective-heavy maps like Cursed Hollow. Throwing a few of those bad boys in will definitely disrupt things more than most characters, and if you score a kill, Li-Ming's passive refreshes your cooldowns. A five second cooldown on teleport also makes her quite the mobile character, especially on maps with lots of twists and turns to phase through. She's fun to play if you're quick with your fingers, as she can both chase and escape (or dodge) damage on a near constant basis. Think of her first Heroic as a modified Diablo Lightning Breath, as she remains stationary for an angled beam attack. It's damage on top of damage, and it works with her passive. But where Li-Ming falters is utility and crowd control. Unlike Kael'thas who has a killer stun, zoning Phoenix Heroic, and a similar kit, Li-Ming is pure damage. Her teleport is self-serving, as is her passive. Her second Heroic can be used as a minor zoning power of sorts with a forgiving 20-second cooldown, but it just isn't enough, and takes insane coordination to really set up a kill like a stun can. As a result, I think Li-Ming is in a good spot balance-wise. Sure she seems overpowered at first glance, but I can already think of a few counters, and she just hit the PTR. Since their debut, Artanis and Morales (the latter especially) have climbed in winrate, as Blizzard tends to favor newer creations first when it comes to balancing. As such, Li-Ming seems like a safe bet to buy when she arrives in early February -- at the very least, she'll be a competent pick. There's also a few big changes coming, as Nova and Rehgar have been completely reworked (nerfs and buffs respectively), and a ton of new stuff is on the way.
Up now on PTR
The last two characters in Heroes of the Storm have ended up with rather disappointing when it comes to rankings. After two weeks, Greymane is the fourth worst hero in terms of win-rate, and Lunara is the fifth worst. That's ...
I'm undecided when it comes to Heroes of the Storm's Greymane
Jan 12
// Chris Carter
[embed]333706:61834:0[/embed] His main gimmick is that as a human he operates as a ranged combatant, and in Worgen form, as a melee fighter. Every single one of his abilities is modified towards each style, like his Q, which throws a cocktail or swipes in a cone at enemies for human and wolf respectively. His W is a generic stat buff of sorts that grants you attack power, and E leaps backward as a Worgen, or forward as a human, altering your state. His Heroics are familiar territory, with a Worgen-centric "Go for the Throat" (that's, you guessed it, an aggressive lunge), or "Marked for the Kill," which is a lot like Tyrande's coveted mark ability to allow increased damage on targets. None of this feels particularly new, especially in comparison to some of the more interesting champions (ha) that have dropped in the past several months. Note that you can't actually shift between forms at will with a convenient passive -- rather, you're restricted to using your E. If you're a human, that means that you need a specific target to leap onto within the range of your circular ability. He also isn't all that exciting after you've grasped his basic moveset, as his entire strategy essentially boils down to damage. Now that's not inherently a bad thing as he is an assassin after all, but he seems to have no real synergy with a group, which is a problem in this stun-based teamfighting meta. Because of these reasons and more, he feels a bit limited and one-dimensional. My favorite thing about him has to be his E though, as it can also be used as in pursuit of foes, and when combined with his burst damage potential and cocktail toss, it's very easy to chase down stragglers and then retreat back into the night. Even with that nice bit of mobility though I'm likely going to fall back to other characters.
15,000 gold or $9.99
Greymane has hit Heroes of the Storm today, entering the arena as the only Worgen character -- the werewolf-like race of Warcraft fame. After an afternoon of giving him a shot though, I'm not super jazzed about fitting him into my normal rotation.
Heroes of the Storm's Lunara sure is fun
Dec 17
// Chris Carter
[embed]327377:61557:0[/embed] She also has a straight-forward set of moves. Her Q is a slightly delayed explosion, her W can be detonated after hitting an enemy with an auto-attack for an extra slow, and her E calls out a Wisp, which can be controlled for scouting. Her kit is fast and furious, and you'll be doing lots of constant clicking with slow cooldowns and poison, damage over time auto-attacks. Positioning is everything with Lunara, because while she can do a ton of damage overall, she's very squishy, and only has one proper escape outside of her raw speed. When it comes to Heroics, I favor her second choice (Leaping Strike), which is a two-charge attack that causes her to leap in the air over her opponent (rendering her unstoppable) for a quick damage spike. This is an escape of sorts, but it can also put you in harm's way if you leap incorrectly (watch the above video at 3:38 for an example). Her other Heroic is a tad less interesting, as it merely damages enemies in a straight line, and doesn't mesh with her mobile playstyle. As for her abilities, I tend to take a few specific ones every time, which increases her utility a bit. At the first level mark I pick up the skill that grants you vision for enemies during the auto-attack poison duration, which, when coupled with her Wisp, helps out your team quite a bit (especially if you're playing cloaked heroes). Speaking of the Wisp, I always take the skill that makes it cost zero mana and grants it a shorter cooldown period. That way, I can constantly use it to scout out camps or objectives -- it took me a bit, but I got in the habit of using it every time it was up, and micro-managing it around the board using the mini-map. It's really hard to tell if a character is balanced when it hasn't even been out a week yet, but Lunara is very fun to play, and my favorite new character since Kharazim. It's important to note though that she works better with planned out team compositions, as she has almost no wave-clearing ability or utility. She is a pure single-target damage dealer. And really, that suits my playstyle just fine.
15,000 gold or $9.99 ($4.99 with sale)
Lunara arrived in Heroes of the Storm this week, and I boosted her up to level 5 in one night alone -- she's that fun to play. As an assassin she's capable of tons of damage (I'm usually top Hero Damage in unranked play)...
Heroes of the Storm
Heroes of the Storm's Cho'gall is freaking weird, but feels balanced
Rolling out today
Nov 17
// Chris Carter
Earlier this month, Blizzard announced a two-player hero in the form of Cho'gall for Heroes of the Storm. In essence, the primary player would control movement and their own set of abilities with Cho, and another would take care of Gall, who is attached to the former -- almost like a permanent Abathur hat. It makes for an interesting playstyle, but of course, it has its drawbacks.
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League of Legends' Kindred sports a killer kit and beautiful design
Oct 28
// Chris Carter
[embed]317933:60896:0[/embed] "Kindred," a new jungler, is actually two characters -- Lamb and Wolf. Their dichotomy is rather interesting, as they symbolize aspects of death, with stark color contrasts to boot. While Riot Games could have half-assed the theme it really went all out, and the animations for Kindred are some of the best in the game, especially when it comes to Wolf's spirit tail effects. I also love dual characters as they have so much potential in terms of interesting skins. So what can they do? Well, Kindred is really more of an active Champion, more so than a lot of others currently on offer. Their W, which doubles as an area-of-effect attack, requires players to constantly move around to build stacks, which triggers health regeneration after attacking. Once you've launched a shot the stack resets, so you better be clicking a mile a minute to keep it up. Given the fact that their E is a slow and their Q is a vault that hits multiple foes, Kindred is a rather versatile Champion that can do a lot more than jungle. This goes double for the pair's ultimate, which creates an area-of-effect space where nothing can die (read: drop below 10% health), friend or foe, for 10 seconds. It's clearly situational and best used when losing a teamfight, but it can completely change the course of a match. By virtue of playing Kindred, players can select a Champion to "hunt" by clicking on their portrait. After killing that target, you'll gain a permanent stat increase, and a lengthy cooldown will be in place for the same player -- though you can switch it up at will. Jungling is also a ton of fun, as you can kite enemies with your range and vault ability, allowing for some interesting early game play. Their E is also perfect for setting up ganks while roaming. While Kindred is a beast, Riot might be gearing up for a nerf at some point. It's very easy to gain an advantage over lesser players by hunting them constantly, as all you need is roughly two or three people to pick on throughout the match to gain the upper hand, stat-wise. This stacks very well with armor penetration gear. In the meantime the Champion requires a ton of skill to play and relies on a good team to shine, so pick the duo up if you haven't already.
Two characters in one
It's getting to the point where I'm starting to get lost when selecting a Champion in League of Legends. Sure, the newest kid on the block, Kindred, has a giant floating mask for an icon and the list is in alphabetical order,...
Heroes of the Storm
I'm not sold on Heroes of the Storm's Artanis yet
The game's first StarCraft Warrior
Oct 21
// Chris Carter
Heroes of the Storm's Artanis isn't dropping officially until October 27, but those of you who pre-ordered Legacy of the Void can play him now, as part of an early access program. While Artanis might be a formidable foe within the confines of the StarCraft universe, I'm not sure I'll be using him to suit my Warrior needs.
Heroes of the Storm's Medic is the dedicated healer we needed
Not a hybrid
Sep 29
// Chris Carter
Kharazim is probably my favorite character in Heroes of the Storm at the moment, but it's about time that we got the StarCraft healer we've always wanted with Lt. Morales, the Medic. With a number of supports e...
Quick thoughts on Heroes of the Storm's Rexxar
Bear is driving! How can that be?
Sep 08
// Chris Carter
Heroes of the Storm is stepping away from the Diablo event as of today, and is focusing more on Warcraft and Starcraft in the coming months. The Treasure Goblins are out, and Rexxar, the half-orc half-ogre is in, with his partner Misha the bear (albeit with some launch issues for some). Here's some quick thoughts on whether or not he's worth your 15,000 gold.
Heroes new map/Monk
Quick thoughts on Heroes of the Storm's Monk and new Infernal Shrines level
Currently on PTR
Aug 11
// Chris Carter
Blizzard has unleashed a host of new changes onto the public test realm (PTR) for Heroes of the Storm, including a new character (Kharazim the Monk) and a new map (Infernal Shrines). I had a chance to take them both for a spi...
Heroes of the Storm's Leoric is another unique addition to the entire MOBA genre
Jul 21
// Chris Carter
Leroic's Q is a simple bash called Skeletal Swing, and would be extremely boring if it didn't do double damage to minions and cause a slow. Because of this, it has a lot of utility in terms of clearing waves and chasing or escaping. It also has a much longer range than I thought it would with a giant modified cone (you can spec it to reach even more distance!), and can go through gates/walls. Not to mention the fact that it's perfect for clearing out smaller creeps in the mines and garden. Drain Hope (W) is a bolt of sorts that allows him to heal, which helps his viability as a warrior class and adds some range to his kit. It only works on heroes, just like Thrall's wolves, so he can't just heal himself in any circumstance -- plus, he needs to maintain a specific distance to channel. Wraith Walk (E) is a really cool teleport, which lets Leoric become unstoppable for a few seconds and phase shift a short distance. He's much more mobile than a lot of other heroes because of this, but his body is vulnerable while he uses it. As you can see, most of his abilities can be countered. In terms of his Heroics, Entomb is a good way in theory to guarantee a single enemy death (it literally causes an impassable tomb to appear), but after extensive testing, I'm going to say that it's just straight-up not very good. It's a little tougher to aim than Butcher's Lamb to the Slaughter, and it's easily countered with a quick Bolt of the Storm or any teleport right towards the open side. His other Heroic, March of the Black King, is likely going to be the top pick by most people. In essence, Leoric whacks everything in front of him in rapid succession, which causes him to heal while he's at it. It's an amazing initiation, as most enemies will likely have to run away from its fairly big area of effect, lest they allow him to heal. [embed]296386:59624:0[/embed] Ok, so it's a fairly easy-to-grasp kit, but his trait is really where he shines -- even when he's KOed, he doesn't technically "die," and can still persist on the battlefield as a wraith. He doesn't do direct damage, but he can use his abilities to reduce his death timer, and return to the board wherever you happen to leave his ghost. Because of this, Leoric has 100% uptime. Now, rising from the dead isn't a completely new MOBA concept -- it isn't even new to Heroes (Uther) -- but since the entire character is built around it and he can do it at level one, it makes for some very interesting gameplay. I love how a lot of his traits are built to work for both variants, and you can even hearth back to base while "dead." It obviously works best with specific objectives, like the Dragon Shire shrines, where you can come right back while the enemy is low on health. Since you can clearly see his ghost as an enemy, it's easy to plan for his resurrection, but the vision his death form grants is a huge factor. When I played the Butcher the day he debuted, I could tell he was fairly balanced with only 10 or so games under my belt. He has a pretty straightforward role, and there are a multitude of counters you can use against him so long as the enemy team is working together. With Leoric, it's much harder to tell where he fits in the current meta, and whether he will need buff or nerf tweaks long term. He's not particularly bursty until later levels and his deaths do grant full kill bonuses for the enemy team, so I can see a lot of players being reckless at low-level play to balance him out in Quick Match. Additionally, he's slow in general, doesn't quite feel as sturdy as some other dedicated tanks, and all his cooldowns take a while to recharge. Right now, I'm fairly happy with where Leoric is at, but again, it's too early to tell what plans Blizzard has for him and if he'll end up being a viable hero in the future. We'll have to keep a close eye on his win rates.
What is dead may never die
Today, Blizzard dropped Leoric the Skeleton King, the newest addition to Heroes of the Storm. He's a melee Warrior with one very intriguing trait, and has a heavy amount of lore to draw upon from the Diablo series. In short, he's a perfect candidate for the game, and Blizzard has been on a roll since debuting Kael'Thas, Johanna, and Butcher respectively.
League of Legend's Tahm Kench is hard to play, but rewarding
Jul 10
// Chris Carter
First off, his overall design is brilliant. He's billed as a southern gentleman with an acquired taste, which works perfectly juxtaposed to his horrid visage. The character is hilarious, spouting out quotes like "I refuse to resign to culinary degradation" while devouring enemies whole, and his standard getup (as well as his chef skin) just work. It's a good balance between absurdity and fitting within the confines of the League universe. While a lot of depth lies under the surface, Kench is fairly easy to pick up, as he sports a skillshot tongue lash (Q), close-range devour (W), a passive/shield (E), and a straightforward (R) ultimate. By hitting an enemy with auto-attacks you can apply "acquired taste," which buffs tongue lash (giving it a stun) or devour. Devour specifically requires you to apply three tacks of taste before gobbling an enemy Champion, forcing Tahm Kench to be more aggressive than most people may like. It's also limited, as his movement speed is severely slowed while carrying an enemy -- so you can't instantly dive back to your own tower unless they're really aggressive. Stacks of acquired taste are shown very clearly with a fish-icon overlay, and applying a slowing debuff with tongue lash while chasing is a great way to gradually earn said stacks while an enemy is running away. Devouring enemy Champions doesn't feel cheap, as it requires a bit of finesse to pull off, and again, you're slowed as a result. His grey health regeneration passive can also be activated as a shield to deceptively increase his tankiness. Kench's ultimate allows for a certain degree of map control since he can instantly become a "hub," so to speak, for another ally to click on. Reactivating said ultimate employs a swift means of transport to a target location in a large radial area. It's really fun to find an enemy teleporting in plain sight on the map, ult over, and tongue lash them to prevent them from running off. Likewise, you can easily set up ganks at early levels by transporting carries in and allowing them to get a kill. It's not instantaneous, though -- it takes a few seconds to channel and you have a second or so of a delay after arrival. One thing to note is that devour is a bit buggy at the moment. You're supposed to be able to tongue lash into a devour, but it doesn't work a good deal of the time. This (presumably temporary) limitation highlights the fact that if you want to play Tahm Kench at a high level, you need to work for it. Since he doesn't do much damage, you need to complement your team more than a lot of other supports. With the right amount of communication, he can shine. [embed]295757:59457:0[/embed] Playing Tahm Kench is probably the most fun I've had with League of Legends in months. He's unique from a gameplay perspective, with a personality to boot, and I think that once people start getting the hang of him, he'll be a viable pick in ranked play.
A real southern gentleman
Despite its tenacity in the past, Riot Games hasn't added a lot of Champions to League of Legends' roster this year. You have Bard in March, Ekko in June, and now, Tahm Kench this month -- that's it. Having said all that, all three have been great additions overall, and the fishy Kench is no exception.
Heroes of the Storm's Butcher is another great inclusion
Jun 30
// Chris Carter
The Butcher is an interesting mix of styles, despite his labeled as an assassin. While he is big, he's not necessarily "tanky" in that he's an easy target while being focused. You also have to micromanage him at the start, as he needs to collect "meat stacks," power-ups dropped by enemy minions to charge up his attack power. Using the various talents acquired on your journey to level 20, you can reward yourself for constantly staying on top of your meat meter, with abilities like a higher meat cap and the ability to heal yourself from pickups. Or, you can simply build up your abilities. His standard "Q" is a straight line skillshot, and slows enemies in its path. It's very aggressive. You can chase down enemies, Q them, and a few seconds later, Q them again. Much like wandering with enemy stealth combatants unaccounted for, going solo with the Butcher roaming around isn't a great idea. This is exacerbated by his "E," which is a mad dash that grants him "unstoppable" status and stuns the enemy for a second after reaching his target. I actually found some neat ways to use this, like running away from enemies by targeting minions, or saving teammates who are being chased. It's also a dramatic move, with the target getting a demonic mark on their head and the Butcher giving in to his inner, terrifying bloodlust. It's powerful for sure, but it also has a long cooldown of 20 seconds. His "W" is probably his least interesting ability, as it can mark a target for a limited time which grants him health while attacking said marked enemy. I've found that for the most part in teamfights, the amount of healing involved isn't really sufficient enough to prevent you from dying, and it would have been more interesting if it gave teammates a low leech percentage (though you can spec it to heal more and grant movement speed). [embed]295040:59292:0[/embed] His ultimate (Heroic) powers are much more interesting. Furnace Blast is an area-of-effect (AOE) blast in a circle around him, and Lamb to the Slaughter chains an enemy to a hitching post for four seconds (it chains anyone in the radius at level 20). The first Heroic doesn't sound all that interesting, but it has a cool visual effect and can be used while charging with your "E," making it a bit more nuanced. The hitching post is my personal favorite, as it augments the Butcher's keen ability to kill lone heroes while they're hilariously chained in place. This works even better if you're ganking enemies with a partner like Nazeebo, who has enough time to set up his Zombie Wall. I also had a chance to test out the "Iron Butcher" skin as well as the "Butcher's Battle Beast" mount that's exclusive to his bundle. The mount isn't anything to write home about, as it's mostly just an existing Battle Beast with some iron armor added on top. It's exclusive to the bundle though, so some of you may want to spring for it. As for the Iron Butcher, it's a pretty safe choice, but it does fit the character and the fact that his face is covered does give him a new enough look compared to some of the other skins. While the jury is still out on whether or not the Butcher is balanced (it's the first day!), he certainly feels like it. To really capitalize with the hero you'll need to play your cards right, and with a distinct lack of escape abilities and the meat mechanic, players will need to master his ins and outs to truly perform. For now though, I'm happy with the results, and I'm tempted to work on my fifth master skin with him.
15,000 gold or $9.99
Heroes of the Storm has just kicked off its Eternal Conflict event, which will bring more Diablo-related content into the game over the course of the next few months. Characters, mounts, and a new level are a part of the cele...
League of Legends roundup: Azir, Kalista, Rek'Sai, Bard, and Ekko
Jun 09
// Chris Carter
Azir's whole gimmick is that he summons Sand Soldier units, which are statues of sorts. They're not really their own entities with health bars, however -- more like extensions of Azir, who is a mage first, marksman second. His soldiers cannot be targeted, which makes him fun (or a pain against) in the laning phase. He's also great at chasing as he can dash to his soldiers using his E. One of the best things about Azir is his innate ability to summon Sun Discs in place of destroyed towers, which creates a mini-tower for a limited period of time. He's very hard to get used to, but a worthy addition to League. I have a lot of fun using him in ARAM, but I believe he is a viable competitive Champion with the right composition. Kalista is a weird character, with a variety of different ranged attacks as a marksman. She can become "Oathsworn" with another ally, essentially boosting her stats and her damage while they are near each other or attack the same target. As you can probably tell, this requires a ton of communication, or at least, a lot of trust with one other player. While winding up her standard skillshot, you can cancel with a quick click to lunge in a direction -- think of it like a free dash. She can also send a ghost out to sentry, and her ultimate can "call" her Oathsworn player to her if they so choose to answer said call (with a range limit), which is also a knock-up. All in all I wouldn't say that she's a particularly interesting Champion, but going in with another friend and laning as Oathsworn buddies can be fun. She's also considered one of the most competitive Champions in recent months, though I won't be using her consistently. Rek'Sai is a bug who fulfills the fighter role, and does what many bugs do best -- she burrows. As one of her chief abilities, burrowing will modify all of her other powers. For instance, an ability that would buff her next three basic attacks is now a skillshot, and she can create tunnel exits to burrow back to, but burrowing does negate basic attacks, and thus, your damage output. Where Rek'Sai excels is mobility. She can quickly get from place to place, allowing her to assist in teamfights, small skirmishes, and when necessary, jungle situations. I enjoyed her as a whole more than Azir and Kalista, and it seems as if the community has taken to her as well. She was re-balanced shortly after her release, and a new nerf is on the way that may take her down a peg overall. Bard the support has an awesome aesthetic to him that fits League of Legends quite well. His Q is a standard skillshot that slows, but the sound and visual effects have a real pop to them. As a support ability, he can drop shrines that boost movement speed and heal -- this simple move is pretty deep, as Bard can place them strategically behind towers to reduce time away from laning or just put them on the ground below him to immediately heal. You'll also need to pay a bit more attention playing as Bard, as you'll be required to periodically grab unique chime icons on the map to buff your auto-attacks. His coolest ability though is the power to create a portal through terrain, which both enemies and allies can use. It looks cool, and it's an effective way of crashing in on enemy creep kills. Bard's ultimate puts everyone in a circle in a stasis, including all heroes and minions -- much like Zeratul's Void Prison ult in Heroes of the Storm, or many other similar MOBA abilities. All told, Bard is by far my favorite champion that I've played in months, and I highly recommend picking him up for fun. It's appropriate that Ekko, the boy who shattered time, has most of his abilities linked to movement speed. As an assassin, it's Ekko's job to pick out individual targets and burst them down rapidly. His passive allows him to build up stacks on a foe, slowing them after three stacks and dealing damage. Like most new heroes these days he has a token skillshot (that creates a slowing field), an area-of-effect slow dome, and a dash. His ultimate is where things get more interesting. Chronobreak is basically an "oh shit" button, making him invulnerable and transporting him back to his location four seconds ago. It allows him to get out of a sticky situation and continue picking off other Champions as well as deal some damage at the location. Ekko is a pure assassin, no frills -- and that's a good thing. While all Champions aren't created equal, I'm excited to see what Riot Games has in store for us in 2015 and beyond.
Time to play catchup
It's been an eventful past six months for League of Legends. While I've been covering new Champions since 2013, I slipped a bit since Gnar late in 2014, as a few other major MMOs as well as fellow MOBA Heroes of the...
Some quick thoughts on League of Legends' Braum and Gnar
Aug 18
// Chris Carter
[embed]279768:55330:0[/embed] Braum is the latest mustachioed hero to hit League of Legends, and his design fits the game perfectly. Although his "dragonslayer" skin isn't really worth buying, his standard skin is one of the stronger models in League, and the fact that he uses his giant shield as a weapon is hilarious. Braum's moves are straightforward -- he has a slowing projectile, a shield dash (just like a few other support characters), a blocking ability, and a straight-line pop-up ultimate. On paper, all of these powers have been seen before, but in tandem, they all meld very well. A lot of people prefer to play as a carry for more glory by way of kills, but I think it's incredibly satisfying to set up teammates with kills instead. Braum has a lot of tools in his shed, including his passive stun, his Q slow, and his ultimate pop-up. One of my favorite new things in League is dashing towards a teammate with Braum's W, then putting up his E shield to block an incoming attack that would hit multiple players. Braum is a true support character, and definitely a fun addition to the game -- it helps to play him with friends though, rather than random people who may not gel with the support type. Having said that, I wouldn't expect a whole lot from Braum in terms of originality -- especially after seeing what Gnar brings to the table. I'd only recommend him to support junkies. [embed]279768:55329:0[/embed] Gnar is a unique champion, and one that I fell in love with after my first game with him. Billed as a yordle that was born a "millennia ago," Gnar was frozen in ice, and has a passive "Rage Gene" that allows him to transform into a giant beast. The catch: "rage" is the key word here, as he gains power by way of a separate bar to transform into said beast -- and he can't really control when the transformation takes place (although you'll see the bar approach 100/100 and you'll get a transformation imminent animation). As such, you'll have access to a Jekyll and Hyde character of sorts, one who is super fast but fragile, and the other who is slow but tanky. Gnar's standard form is quick, allowing constant speed boosts and even a "hop" move that lets him escape and pursue. His boomerang power is one of my favorite skillshots, as it allows him to "catch" the projectile to shorten the cooldown, or let it run to potentially hit more enemies. It's perfect for laning and harassing -- since it slows the first enemy it touches. The "Mega" version of Gnar has access to similar moves, but instead of a swift boomerang and an agile hop, he throws boulders and slams the ground. It's really fun to do well as the tiny version, then all of a sudden have access to Mega Gnar, run in, and wreck shop with all your new cooldowns. That's not to say that he's easy to play, as any player can run down the tiny Gnar (which you'll be playing as most of the time) and slice him to bits in seconds. You have to play conservatively and run in at the right times, sometimes with split-second decisions in tow, which makes Gnar a really fun champion to play, and a great unpredictable addition to League of Legends. He's also easy to pick up at first since his core form has two passive-like skills -- so you only really have to master his hop and boomerang initially.
The two newest champions
I've been covering every new League of Legends champion for over a year now, but ever since Braum dropped, I haven't had the chance to really get in and play as many ranked games as I would have liked due to a few other ...
LoL Vel�Koz
Impressions: League of Legends: Vel Koz
The Eye of the Void vies for your Riot Points
Mar 14
// Chris Carter
Riot keeps introducing new League of Legends champions, and we keep trying them out. The newest addition to the Summoner's Rift is Vel'Koz -- The Eye of the Void. He's a bit out of place in many ways, with an aesthetic design that isn't normally utilized in in the game, and likewise, he's a bit unconventional in terms of gameplay.
LoL Yasuo
Impressions: League of Legends: Yasuo
The Unforgiven vies for your Riot Points
Dec 16
// Chris Carter
Samurais -- am I right? In the world of gaming, the "ronin/wandering samurai" trope is one of the most overused character designs I can think of, especially in the early 2000s, with the host of samurai-centric games on the or...
League of Legends
Impressions: League of Legends: Jinx
The Loose Cannon vies for your Riot Points
Oct 16
// Chris Carter
With the League of Legends 2013 Championship out of the way, it's time to get back to the grindstone and start testing out some new characters. The first post-Finals addition is Jinx, the "Loose Cannon," and she's...interesti...
League of Legends
Impressions: League of Legends: Lucian
The Purifier vies for your Riot Points
Sep 10
// Chris Carter
The League of Legends train won't stop running anytime soon, as Riot Games is still keen on constantly updating the game with new champions. The gunslinging paladin Lucian is the latest champion on the block, poised to compet...
League of Legends
Impressions: League of Legends: Aatrox
The Darkin Blade vies for your Riot Points
Jun 17
// Chris Carter
I wasn't blown away with the previous addition to League of Legends, Lissandra, but as soon as I laid eyes on Aatrox, I knew I had to take him for a spin. With a giant pulsing blade, demonic looking wings and mysterious past, the sky was the limit for Aatrox. Yep, he plays just as cool as he looks.
League of Legends
Impressions: League of Legends: Lissandra
The ice witch vies for your Riot Points
May 07
// Chris Carter
League of Legends has just launched a new champion, which means many of you are considering digging out your wallets and forking over the cash or in-game IP to have the chance to try her out. This time, it's another caster ce...
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NEW YORK -- Former Boston Red Sox manager Bobby Valentine will work as a commentator for NBC Sports Radio. He will be the part-time co-host of a weekday talk show that debuts in April. Starting this month, he will also periodically provide analysis to NBC ...
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An efficient magnetically modified microbial cell biocomposite for carbazole biodegradation
© Li et al.; licensee Springer. 2013
Received: 2 September 2013
Accepted: 4 December 2013
Published: 11 December 2013
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© Li et al.; licensee Springer. 2013
Received: 2 September 2013
Accepted: 4 December 2013
Published: 11 December 2013
Magnetic modification of microbial cells enables to prepare smart biocomposites in bioremediation. In this study, we constructed an efficient biocomposite by assembling Fe3O4 nanoparticles onto the surface of Sphingomonas sp. XLDN2-5 cells. The average particle size of Fe3O4 nanoparticles was about 20 nm with 45.5 emu g-1 saturation magnetization. The morphology of Sphingomonas sp. XLDN2-5 cells before and after Fe3O4 nanoparticle loading was verified by scanning electron microscopy and transmission electronic microscopy. Compared with free cells, the microbial cell/Fe3O4 biocomposite had the same biodegradation activity but exhibited remarkable reusability. The degradation activity of the microbial cell/Fe3O4 biocomposite increased gradually during recycling processes. Additionally, the microbial cell/Fe3O4 biocomposite could be easily separated and recycled by an external magnetic field due to the super-paramagnetic properties of Fe3O4 nanoparticle coating. These results indicated that magnetically modified microbial cells provide a promising technique for improving biocatalysts used in the biodegradation of hazardous compounds.
As types of toxic and mutagenic common nitrogen compounds, carbazole and its derivatives readily undergo radical chemistry to generate the more poisonous hydroxynitrocarbazoles [1–4]. Soil, river sediments, and ground water polluted by carbazole have become a great threat to the environment. Therefore, it is necessary to establish effective methods to clear up carbazole and its derivatives.
Nanoscale iron particles represent a new generation of environmental remediation technologies that could provide cost-effective solutions to some of the most challenging environmental cleanup problems [5]. Due to biocompatibility, large surface areas, high surface reactivity, and super-paramagnetic properties, nanoscale iron particles provide enormous flexibility for environmental applications [6–8]. Research has shown that nanoscale iron particles are very effective for the transformation and detoxification of a wide variety of common environmental contaminants, such as hazardous organic compound [9–11] and heavy metal ions [8, 12].
The use of immobilized microorganisms rather than free cells in biodegradation can be advantageous to enhance the stability of the biocatalyst and to facilitate its recovery and reuse. Entrapment method as a traditional method is widely used in the immobilization of microorganisms [13]. In our previous study, Sphingomonas sp. XLDN2-5 as a carbazole-degrading strain was entrapped in the mixture of Fe3O4 nanoparticles and gellan gum using modified traditional entrapment method [7]. However, the mass-transfer problems of limited diffusion and steric hindrance reduced microbial cell access to substrate [14]. Therefore, we constructed an efficient biocomposite by assembling Fe3O4 nanoparticles onto the surface of Sphingomonas sp. XLDN2-5 cells in this study. The resulting microbial cell/Fe3O4 biocomposite exhibited good biodegradation activity and reusability.
Analytical grade carbazole was purchased from Sigma-Aldrich (St. Louis, MO, USA). All other chemicals were of analytical grade and commercially available.
Sphingomonas sp. XLDN2-5, which can use carbazole as the sole source of carbon, nitrogen, and energy, was cultivated in the mineral salts medium (MSM) as previously described [15]. Cells were harvested in the exponential phase (the optical density was about 0.68 to 0.70 at 620 nm) by centrifugation at 12,000 rpm for 10 min. The pellet was washed thrice with sodium chloride solution (0.9%, w/v) and then resuspended in sodium chloride solution (0.9%, w/v).
Fe3O4 nanoparticles were prepared as previously described [7]. Fe3O4 powder (1.0 g) was put into 100 ml distilled water to form the Fe3O4 particle suspension. After ultrasonic disruption (25 KHz, 10 min; BUG25-06, Branson, MO, USA) of the suspension, the Fe3O4 nanoparticles were well dispersed in distilled water to form a stable suspension.
Fe3O4 particle suspension (1%, w/v) and cell suspension were mixed with the ratio of cell wet weight to Fe3O4 of 1 (w/w). Microbial cells and Fe3O4 nanoparticles were fully mixed by vortexing, then the mixture was incubated at 30°C for 2 h in a dark shaker to obtain microbial cell/Fe3O4 biocomposites.
All biodegradation experiments were carried out in 100-ml flasks containing 10-ml MSM at 30°C on a reciprocal shaker at 180 rpm. In each experiment, 3,500 μg of carbazole was added to MSM, and the microbial cell/Fe3O4 biocomposites made by 2 ml mixture of Fe3O4 particle suspension and cell suspension served as biocatalysts. Additionally, the same amount of cells was conducted in the batch biodegradation experiment. All the subsequent experiments contained the same amount of carbazole and biocatalysts as above.
In the recycle experiments, after each batch of biodegradation, the microbial cell/Fe3O4 biocomposites were collected using a magnetic field, and then were washed thrice with MSM to remove the free cells. After the MSM was drained, 10 ml of fresh MSM containing carbazole was added to repeat the cycle. All experiments were performed in triplicate.
After each batch of biodegradation, the biodegradation mixture was added 20 ml ethanol, followed by centrifugation (12,000 rpm for 20 min) and filtration. Residual contents of carbazole were determined using High-performance liquid chromatography (HPLC). HPLC was performed with an Agilent 1100 series (Hewlett-Packard) instrument equipped with a reversed-phase C18 column (4.6 mm × 150 mm, Hewlett-Packard). The mobile phase was a mixture of methanol and deionized water (90:10, v/v) at a flow rate of 0.5 ml min-1, and carbazole was monitored at 254 nm with a variable-wavelength detector.
The size and morphology of magnetic nanoparticles and microbial cell/Fe3O4 biocomposite were determined by transmission electronic microscopy (TEM; JEM-100cx II, JEOL, Akishima-shi, Japan). The sample was prepared by evaporating a drop of properly diluted microbial cell/Fe3O4 biocomposite or nanoparticle suspension on a carbon copper grid. The morphology of free cells was determined using a scanning electron microscope (SEM; S-570, Hitachi, Chiyoda-ku, Japan). Magnetization curves for the magnetic immobilized cells were obtained with a vibrating sample magnetometer (MicroMag 2900/3900, Princeton Measurements Corp., Westerville, OH, USA).
In an industrial bioremediation process, the recycle of the biocatalysts could be an important factor that determines the effectiveness of degradation for a long time. The carbazole biodegradation activities of microbial cell/Fe3O4 biocomposite were tested repeatedly. Each test was performed until the carbazole was consumed completely. At the end of each test, the microbial cell/Fe3O4 biocomposites were collected by application of a magnetic field and then reused in another test. As shown in Figure 4B, from the first to the sixth cycle, 3,500 μg carbazole was completely consumed by microbial cell/Fe3O4 biocomposite in 9 h; from the seventh to the tenth cycle, the same amount of carbazole was completely consumed in only 2 h. It was clear that the biodegradation activity of microbial cell/Fe3O4 biocomposites increased gradually during the recycling processes, which may be due to that more microbial cells was immobilized by Fe3O4 nanoparticles with the microbial cell growth and reproduction. Additionally, carbazole can be quickly transferred to the biocatalyst surface where nanosorbents were located and resulted in the increase of biodegradation rate [10, 14]. These results are different from other researchers' report which stated that the desulfurization activity of microbial cells coated by magnetite nanoparticles decreased gradually after a few test cycles [11].
In conclusion, the microbial cell/Fe3O4 biocomposite was evaluated as a novel aspect of the industrialization of microbial cell immobilization. Moreover, magnetic (Fe3O4) nanoparticles have a large specific surface and super-paramagnetic properties, which not only reduced the mass transfer resistance of traditional immobilization method, but also facilitated the recovery of immobilized cells in the reuse process. Additionally, the recycle experiments demonstrated that the biodegradation activity of microbial cell/Fe3O4 biocomposites increased gradually during the recycling processes. These results indicated that magnetically modified microbial cells provide a promising technique for improving biocatalysts used in the biodegradation of hazardous organic compounds.
This work was supported by grants from the National Natural Science Foundation of China (21177074), Excellent Middle-Aged and Youth Scientist Award Foundation of Shandong Province (BS2010SW016), and New Teacher Foundation of Ministry of Education of China (20090131120005).
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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saint seiya - ikki and shun by spoonybardsWatch
©2011-2016 spoonybards
Just a quick thing I did yesterday, but I wanted to upload something new to DA! +_+ I've been getting into Saint Seiya pretty recently (I am forever late to fandoms) and have been loving it! Can't wait to get further with already so much I want to draw :9
UOOOOOOOOOOOOOOOOOOHHH!! CUUUUUTEEEE!!! we love saint seiya foreverrrr!!!
INSTA FAVEEEEE i love saint seiya *o*
MAN WE NEED TO BE FRIENDS, I enjoy your taste!! Are you ever on AIM?
o-oh god i'm 100% less interesting in a live chat b-but it's susamitsunami asdfgh what's yours?
You're a genius!
I love this, the style made makes them look so fresh and originalXD
shun you so moe
(so business as usual)
(so business as usual)