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Based on the fact that for me a hero is someone that lives it's life improving other people's life always in a good way but also, not being selfish whem making it's own decisions, then, there's no way that someone could be a hero all the time, imagine that!, even in the greek tragedy, the heroes have they glory time and then something bad happens that questions its morality, then after they made a mistake they need to think how to be even better and go back the good track, that's the big deal, we all fail at some point, but a hero will emend that failure and do the things better.
So who's a hero? not somebody who never felt temptation to do something bad, but the one who felt it but prefered to go on the other way. Someone who made a mistake, but realized about it and tryed to not doing it anymore and to correct it. Haven't you felt how difficult it is to accept when you are wrong, but also to face it to others and prove you can do it right?.
I've met a lot of people, they all make at some point mistakes in their lifes, the women that I work with they are not perfect, they sometimes don't take the decisions according to everyones necesity but at the important moment, when they face reality and how they can actually change it, then, they think about everyone, everything, and all of then become the heroes of their story.
And I could go on like that, remebering all the people that I had the opportunity to meet when they were being their heroes, or that I accidentally or in purpose helped them to be their own heroes; I've met a journalist who never sold it's conscience to anyone but to the truth; I've met a priest who do more than pray, he knew how to farm, he knew how to recycle paper, he knew how to do productive projects and he always shared he's knowledge; I've met my aunt, who had more patience that anyone that I've ever met, and she was always right; and of course, I have my mother, who has lived an incredible life, full of challenges and deceptions but she keeps going, and I go next to her.
The point is, to realize what makes you your own hero, what brings us to live and encourages the others to follow the example, and what moment of sadness or just a difficult moment, we try not just to get over it barely, but to do it even better.
I copied this and posted it on my fridge. It is a reminder on how I should live my life and mold my thoughts. Your words echo in my heart and make me realize the importance of not only being honest with other people but honest with myself. I am truly inspired by your voice and look forward to read more from you.
With encouragement and support, Carri
I've read your comment since you wrote it but I didn't have the time to answer it properly, sorry for that. You can't imagine how happy made me to read you, you were really nice and cheerful for me to keep writing, and also working, you know the work in a NGO that is truly oriented to help people it's not always known and when we say what we do sometimes it tends to be even suspicious like "how can they do all that and we don't know?" we were always working by the thought that we shouldn't be bragging about our work, but how can people be motivated to do something if they don't know it's actually pretty possible and not just a dream?. So now were in a new period of work, try to let people know what we do, and still keep doing our jobs, so we have work like crazy hahaha. Please keep reading. Have a great day!!!
Ángeles Ronquillo
Puebla, México.
Your words carry so much wisdom. If only we each, every day, gave notice to those people close by who are doing small acts of kindness and being strong for their family, their community. Being a hero is so much more important than being a celebrity. But the celebrity gets too much attention; the ordinary hero/heroine, too little attention!
Thank you for sharing all that you do, ~Karen
Yes you're right, the real hero/heroine does not get too much attention, and it's because it does what has to do without telling everybody, so they work becomes part of their lives, like if was an obligation so it's not seen as an act of good will. And sometimes we are that hard with ourselves too, when we do something wrong we can stay up all night thinking bad thinks about ourselves and tends to be quite depressing, but when we do something good, we just do it, instead of thinking, I do something good cause I'm a good person who can be even better.
Ángeles Ronquillo
Puebla, México.


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Medieval Lords: Build, Defend, Expand
Question from james198523
Can medieval lords ever work on windows 7?
I have medieval lords the game i am trying to install it to my pc which works fine the game install completes fully, the problem i have is that it will not run on windows seven, is there something i can download a (program, patch etc etc) that will allow the game to play? if so can anone let me know thanks.
6 years ago
PhantomHack answered:
Its not compatable for vista either it seems
Its not compatable for vista either it seems
5 years ago
This question is open with pending answers, but none have been accepted yet
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subset: commoncrawl


text:
My review
Original recipe yields 25 servings
Based on a 2,000 calorie dietSee full nutrition
Ready In
I made this recently for a Christmas Eve potluck and it was delish! I forgot my grocery list at home, so I improvised a bit. I also don't like vermouth, so I used a dry white wine (a cheap sauvi...
Hints: Puff pastry sheets cut the prep time dramatically! You can sub the vermouth for wine or whatever floats your boat. I keep meaning to take pictures so this recipe gets more popular. It ...
This was good! I could not get a shallot to save my life @ the grocery store, so I subbed green onion, which I thought worked out nicely. I am a lover of garlic, but I think if I make this again...
Really good- I added a handful of chopped mushrooms and sauteed them with the shallot and garlic in a little olive oil before adding the vermouth and putting it on top of the brie.
I modified this, but wanted to rate the combination of the savory ingredients with the Brie, which was excellent. The shallot, garlic, white pepper, and sauvignon blanc (no vermouth) sauteed to...
Better and easier with puff pastry and walnut-studded mango chutney on top of the brie. Wrap pastry up over top of brie and make a decoration on top with the folded up pastry.
Amazing. Everyone raved about this and asked for the recipe! I used white wine instead of vermouth and puff pastry, not phyllo. Will definitely make this again!
The only tip I took from this recipe was....I did take the rind off the top prior to wrapping the brie. This makes an AMAZING difference! The brie melts soooo much better. I made it w the tradi...


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Definitions for puckerˈpʌk ər
This page provides all possible meanings and translations of the word pucker
Princeton's WordNet
pucker, ruck(verb)
an irregular fold in an otherwise even surface (as in cloth)
pucker, rumple, cockle, crumple, knit(verb)
to gather something into small wrinkles or folds
"She puckered her lips"
gather, pucker, tuck(verb)
draw together into folds or puckers
pucker, ruck, ruck up(verb)
become wrinkled or drawn together
"her lips puckered"
A fold or wrinkle.
1921 The mouth was compressed, and on either side of it two tiny wrinkles had formed themselves in her cheeks. An infinity of slightly malicious amusement lurked in those little folds, in the puckers about the half-closed eyes, in the eyes themselves, bright and laughing between the narrowed lids. u2014 Aldous Huxley, Crome Yellow, Chapter 3.
A state of perplexity or anxiety; confusion; bother; agitation.
1874 "What a pucker everything is in!" said Bathsheba, discontentedly when the child had gone. "Get away, Maryann, or go on with your scrubbing, or do something! You ought to be married by this time, and not here troubling me!" u2014 Thomas Hardy, Far From the Madding Crowd.
To pinch or wrinkle; to squeeze inwardly, to dimple or fold.
Origin: Probable alteration of (verb) poke
Webster Dictionary
to gather into small folds or wrinkles; to contract into ridges and furrows; to corrugate; -- often with up; as, to pucker up the mouth
a fold; a wrinkle; a collection of folds
a state of perplexity or anxiety; confusion; bother; agitation
Origin: [From Poke a pocket, small bag.]
Pucker is a line of fruit-flavored imitation liqueurs made by the DeKuyper company. By volume it is 15% alcohol and is often used in mixed drinks such as martinis.
Images & Illustrations of pucker
Translations for pucker
From our Multilingual Translation Dictionary
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Tag "duke nukem 3d"
Duke says: "No Ads!" – Duke Nukem 3D updated after complaints about ads
We reported yesterday on Duke Nukem 3D's release onto the Android Market and of its unusual decision to include ads even though it was a paid app. I personally didn't
Get ready mobile gamers, Duke Nukem 3D finally available for Android
Calling all Duke Nukem fans, I need your attention. Remember when we told you that Duke Nukem would hit the Android Market "very soon?" Well, after only 20 days, the
Duke Nukem 3D Coming to Android "Very Soon"
We might have waited years (and years, and years) for Duke Nukem 3D to arrive on PC and consoles, but us Android fans should see our little version of the


text: Darius RuckerOverviewRelated Content Darius RuckerOverviewRelated Content ShareTweetPinEmail ShareTweetPinEmail ShareTweetPinEmail ShareTweetPinEmail KB4/WENN 1 / 14 ShareTweetPinEmail KB4/WENN 1 / 14 Darius Rucker: Related Content Feb. 04, 2016 Best new artist Grammy winners from 1990 to 2015 -- ranked From Amy Winehouse to Carrie Underwood and Maroon 5, Wonderwall.com reveals its favorite best new artist Grammy winners. Feb. 04, 2016 Share Tweet Nov. 12, 2015 Celebrity style hits and misses for November 2015 Check out the best and worst dressed celebriteis from November 2015! Nov. 12, 2015 Share Tweet Jun. 10, 2015 2015 CMT Music Awards See all the stars who attended the big show in Nashville. Jun. 10, 2015 Share Tweet Apr. 19, 2015 2015 Academy of Country Music Awards Check out country music's biggest stars at the 2015 Academy of Country Music Awards. Apr. 19, 2015 Share Tweet Nov. 05, 2014 2014 CMA Awards See your favorite country music stars at the 2014 CMA Awards! Nov. 05, 2014 Share Tweet Oct. 30, 2014 Tim McGraw, Keith Urban and more modern cowboys See how country music's men are trading in their Stetsons for more modern wear! Oct. 30, 2014 Share Tweet See All Related Content Newsletter Get the latest celeb dish right to your inbox.You know you want it! Sign Me Up! By signing up I accept the Terms and Conditions and Privacy Policy Thanks ForSubscribing! Close ShareTweetPinEmail


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Artwork details
Robert Medley 1905–1994
Summer Eclogue No. 1: Cyclists
Date 1950
Medium Oil paint on canvas
Dimensions Unconfirmed: 1295 x 1600 mm
frame: 1370 x 1676 x 62 mm
frame: 1370 x 1676 x 62 mm
Acquisition Purchased 1992
Not on display
Display caption
As well as a painter, Medley was a theatre designer, designing sets for TS Eliot and WH Auden - who was his lover - in the 1930s. Initially influenced by Bloomsbury and Surrealism, he later became concerned 'with the movement of human figures in space'. This is one of several paintings inspired by weekend parties of cyclists at Gravesend on the Thames. Its treatment of bodies in motion reflects Medley's long association with the theatre, while the word eclogue, an ancient form of pastoral poem, turns the modern scene into a timeless moment. Exhibited at the 1951 Festival of Britain, it adds an important early work to our collection of Medley's paintings.
August 2004
About this artwork
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I have a question. Hope some one would help me.
I want to send some data(in struct fromat) from my iPhone 4S to a bluetooth device over Bluetooth.
The bluetooth device has support for BLE 4.0.(as required by iOS development)
So I guess Core Bluetooth Framework should help.
I just wanted to know if it is possible to send command from iPhone to my bluetooth device.
If yes then how. If someone can help me ,it would be very helpful for me.


text:
FALL ARTS: Fall is here, and women are ruling the Bay Area rock scene
The cover of Grass Widow's second, newly released album, Past Time (Kill Rock Stars), appears to sidestep the issue, until you look closely and notice Lew, guitarist-vocalist Raven Mahon, and drummer-vocalist Lillian Maring poking their heads out a car window in the background. "We're very blurry, but we could be really hot!" Lew jokes. "We probably are really hot!"
Some consider Grass Widow hot for altogether different reasons: the band is often brought up by other all-female local bands as a favorite, and Past Time stands to find a place beside such influential groups as the Raincoats for its blend of sweetness and dissonance, spare instrumentation and sing-out confidence, and interwoven vocals. In some ways, Grass Widow sounds as if it's starting from scratch in a post-punk universe and going forward from there, violating rockist convention.
Are they, as their name might suggest, mourning an indie rock that might or might not be dead? Well, when Lew, Mahon, and Maring started playing together in 2007 under the moniker Shit Storm ("It was a self-fulfilling prophecy, like the facial tattoo of band names!" says Lew), they probably couldn't predict how sadly apropos Grass Widow — a centuries-old phrase referring to a woman whose husband is away at sea or war or on duty — would become. Last year, among other events, Lew's father, noted SF Rabbi Alan Lew, passed away. "We took a six-month break during this intense grieving period, and it was strange to come out of it and think, we're in a band called Grass Widow," Lew says now. "And we were grass widows to each other! Then playing again, it felt right to be in a band like that — it took on this other meaning."
In a similar way, the group regularly works together to transform their experiences, thoughts, and dreams through allegory into song lyrics — and for its release party, it plans to incorporate a string section and a 35-lady choir. "We're not a girl group mourning the loss of our boyfriends and waiting for them to return," muses Mahon. "It's more like we're working together to create and we're functioning just fine that way."
"We're associated with a lot of bands that came along a few years later, but when I started writing songs three or four years ago, it was a wasteland," says Jess Scott, Brilliant Colors' vocalist, guitarist, and songwriter. "It was really hard to find people who wanted to play pop, not hardcore. It seems like a given now, but it was hard to find people who were into Aislers Set."
Scott's tenacity and focus comes through — loud, clear, and as vivid as the brightest hues in your paint set, and the most resonant melodies of Aislers Set — on Brilliant Colors' 2009 debut, Introducing (Slumberland). Her breathy vocals and rhythm guitar — a crisp combination of post-punk spunk and drone — bound off drummer Diane Anastacio's frisky, skipping beats and bassist Michelle Hill's simple, straight-to-the-gut bass lines like the most natural thing in the world, recalling punk classics by early Buzzcocks and Wire as well as later successors Delta 5 and LiliPUT and riot grrrl-era kin Heavens to Betsy and Huggy Bear.
Scott has been writing songs since she was 15, which, full disclosure, was around the time I first met her, the daughter of two moms, one of whom I worked with. At the time, her sound was softer, more melodic, and at times weirder than the punk outfits that frequented 924 Gilman Street Project, her pals' preferred hangout. Nevertheless, Brilliant Colors has gone on to somehow fuse Gilman's political-punk commitment with Scott's obsession with perfecting pop songcraft.
Also from this author
Cheers to CAAMFest's crop of female Asian American film directors
THE YEAR IN FILM: Looking back at a triumphant year for African American films
French synth-pop giants Phoenix and Daft Punk tap into the alien within


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It makes sense to compare the work of contemplation to sleep. When we're asleep, the functions of our physical faculties are suspended so that our bodies can get complete rest. Sleep nourishes and strengthens our bodies in every way. The same is true of the spiritual "sleep" of contemplative prayer. The stubborn questions of our restless spirituality and all our creative and rational thoughts are firmly bound and totally emptied, so the happy soul can sleep soundly, resting profoundly in the loving awareness of God as he is, completely nourished and strengthened in spirit.
— Anonymous, The Book of Privy Counsel,
Carmen A. Butcher translation


text:
You said that you would come again
You said that we would remain friends but
You know that I do not depend on
Nothing or no one
So why would you show up
So uninvited then
Just change my mind like that
Lyric Meaning
He says that even though they're not a couple, they still can remain friends and he will still keep in touch. She takes this as a normal "it's not you, it's me" break-up speech and doesn't count on him to actually go through with what he's saying (she also throws in her trust issues when she says "I don't depend on nothing and no one"). Unexpectedly , he shows up uninvited and she instantly remembers the good times they had .
Improve the quality of The Worst Lyrics by leaving a suggestion at the bottom of the page


text:
Translation of flood in German:
- 1Überschwemmung Fem.the river is in flood floodsÜberschwemmungenwe had a flood in the kitchenunsere Küche stand unter Wasserthe Flood (Bible)die Sintflutattrib.flood areaÜberschwemmungsgebiet Neutr.
- 2 [figurative]Flut Fem.in full floodin voller Stärkein floods of tears
- 3 (Theatre) [informal] → floodlight 1
intransitive verb
- 1(Fluss)there's danger of flooding
über die Ufer tretenes besteht Überschwemmungsgefahrthere's been a lot of flooding in the areaes ist in dem Gebiet schon zu zahlreichen Überschwemmungen gekommen
transitive verb
- 1(with moving liquid) überfluten(deluge, irrigate) unter Wasser setzenthe cellar was floodedder Keller stand unter Wasserbe flooded outdurch eine Überschwemmung obdachlos werden
Definition of flood in:
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- US English synonyms
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Comments that don't adhere to our Community Guidelines may be moderated or removed.
Grammar and usage help for German:
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The Community Economic Development Association of Pollock Pines (CEDAPP) wishes to express heartfelt appreciation to the estimated 150 people who attended the first Winterfest Party in the Pines last night.
We are humbled and ecstatic at the same time that so many folks from across the entire county showed up in such huge numbers to support our little community and its continuing "drive to thrive" as a rural community in a very difficult economic period of time.
Personal thank you letters will be sent to all the volunteers and those who contributed with raffle and silent auction items, but we must publicly say thank you to Dragonfly Acres (EDC's newest venue — hot spot — for exciting events), Sierra At Tahoe for its partnership, Chateau D'avell and Madrona Wineries and Gold Hill Vineyard and Brewery.
Whether people were dancing to Cowboy Neal or enjoying the sounds of Marty Lee, the "climate" at Winterfest was warm, inviting and the perfect time and place to meet new folks to party with.
CEDAPP hosts events all throughout the year, most of which are free to attend for children and adults, but this was a fundraiser when the numbers really do count. So again, from Emily Valdez, the project manager, and the CEDAPP Board, thank you to all of you who believe in us, and help us to keep Pollock Pines pristine in its environment and healthy in its economy.


text:
Provide your corporation's shareholders with an alternative -- and often easier -- way to vote. Shareholders can sign "consents" in the absence of a meeting, which is particularly helpful when:
You Save:
$24.99 (100% discount)
There's more than one way for shareholders to take action. The most familiar way is a shareholders' meeting, but other ways of recording shareholders' votes are growing in popularity.
In particular, the use of signed "consents" by shareholders in the absence of a meeting is quite common nowadays, especially where one or more shareholders live or work a fair distance from the others.
Using a consent can be particularly helpful when:
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I am overwhelmed with the popularity of MoSoap! Right now, (update 11/17/15) I am running a month behind in shipping. Most of the items are sold out. I will restock the online store as soon as possible. Any outstanding orders are my first priority and I am getting all of them out as fast as possible. If you have an outstanding order and would like to cancel due to the delay, please let me know as I completely understand.
Thank you so much as always and I truly do appreciate your business. Debra
Specializing in old fashioned lye soap, pine tar soaps and herbal balms, MoSoap brand handcrafts vintage family recipes for all to enjoy. Whether young or old, our soaps provide a link to the past and honor those who have come before us. As a third generation professional soap maker, whose grandmother learned from her grandmother, I enjoy offering these simple, humble soaps to you that my family has made for many years.
A few of our items are no longer in our line up like bulk log soaps. These will return in late fall of 2015 but for the spring and summer, I am not offering them.


text:
Hostel BaccaratNice, France
Thank you a lot for the very friendly atmosphere, cleanness and convenient location!
- Novice Nomad
- Germany
- Couple, 25-30
- (7 reviews)
HELLO B&BUtrecht, Netherlands
Ha-ha, people, stay there! There was the best hostel, I saw. Many thanks for owner!
JorplaceThe Hague, Netherlands
The bathroom and the toilet were not clean enough at the moment of our stay. No lockers.
Fully Furnished Room in LeidenLeiden, Netherlands
myHostalBremen, Germany
Sleep-StationMuenster, Germany
Max HostelBonn, Germany
The best bonus to my stay was the dance studio downstairs! Was possible to watch and even to join the training! Nevertheless it was not audible in rooms.
- Novice Nomad
- Ukraine
- Female, 18-24
- (7 reviews)


text:
EARTHblog » Nadia Steinzor
It's definitely The Pits: new case study reveals lax waste management in PA
By Nadia Steinzor
September 29, 2014
For most of us, cleaning up after oneself is a basic guideline for living and working with others. Taking responsibility for the environmental costs of products is an emerging business concept. Then there's the oil and gas industry—which prefers a "you deal with it instead" approach to waste management. The result? Tainted rivers downstream from wastewater treatment plants, earthquakes near injection wells, and radioactive drill cuttings in landfills. And then there are the giant pits where operators store millions of gallons of waste at a time.
Tagged with: fracking, pennsylvania, pennsylvania department of environmental protection
Out of sight is not out of mind: Gas storage risks in PA
By Nadia Steinzor
September 18, 2014
With the arrival of chilly nights in the Northeast, an annual debate begins over potential spikes in natural gas prices. It's the season for operators to push pipeline expansion projects and to compare weather predictions with gas supply estimates.
Typically absent from the discussion are the impacts on residents who live near gas facilities—or in the case of gas storage, right on top of them. As Angel and Wayne Smith of Bedford County PA know all too well, this is a glaring and very troubling omission.
Tagged with:


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Top Definition
When you shove cheese into a girl's mouth and a key in her ear and hump her in the other ear while her hands are on her mouth and ear.
Yo I just gave Alexa a keys and cheese, she's now deaf in one ear!
by Jokr November 01, 2007
Type your email address below to get our free Urban Word of the Day every morning!
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text:
Music blog
Johnny Depp Gone Mad Apocalyptic Z Anime Comes Out Of Shell Absolute Magic Of Rickman's Voice MORE ›
Lyrics/song texts are property and copyright of their owners and provided for educational purposes only.
Hidden Wheel Lyrics by Ritchie Family
Hidden Wheel by Ritchie Family
No it never seemed all that much to see
But now it feels so real
Feels so real to me
But now it feels so much
Feels so much to see
Is this the,
The first time
I've seen the color of this room?
Is this the,
The first time?
Yes, I had a taste but I did not swallow
And if I went it was just to follow
And now a question was asked of me
But now there's a question being asked of me
Is this the,
The first time
I've seen the size of these walls?
Is this the,
The first time?
I'm the angry son
Everything I've learned was wrong
I'm the burning door
Once I'm opened I can't be closed
I found a hidden wheel
And it rolls to reveal that
I'm the angry son
I'm the angry son


text:
STARmeterSEE RANK
Up 991 this week
John Challis (I)
John Challis is an accomplished character actor, personality and raconteur whose wide-ranging career has ranged from classical roles on the stage to heavies in television drama, a multitude of policemen, sitcom stardom, pantomime performances and even a one-man show. He wanted to act from a young age but was encouraged to get a "proper" job, so he ... See full bio »
Born:in Bristol, England, UK
More at IMDbPro » Contact Info: View agent
Represent John Challis? Add or change photos


text:
Tags: GlasPave
Flexco adds three employees at Bolingbrook, Illinois, facility
Flexco has hired three new employees to its facility in Bolingbrook, Ill. Kevin Moran and Mike Mass were appointed project managers, while Joel Wagner was brought to Flexco as a design engineer to support its transfer chute product line.
Moran and ... Read More...
Read More...
Tensar International appoints Libby Hungerford to Central Area regional sales manager team
Tensar International Corp. has appointed Libby Hungerford to the Central Area regional sales manager team.
In her new role, Hungerford will manage technical promotion, design support, sales and distribution for the central U.S. She will partner with construction product distributors, Carter ... Read More...
Read More...
Cat participating in Jeffries Global Industrial and A&D Conference, Webcast
Caterpillar Inc. Director of Investor Relations Mike DeWalt will be speaking at the Jefferies Global Industrial and A&D Conference on Thursday, Aug. 11, 2011.
He is scheduled to speak at 11 a.m. Eastern Time. The presentation materials will be available Wednesday, ... Read More...
Read More...
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- LafargeHolcim is considering selling Lafarge India280 Views


text:
SlashIn ( /in )
|Jun 24, 2015
|Description Provides the /in command for delayed execution. Also provides /slashin, in case of conflicts with other addons providing /in. Many addons have provided this feature -- so many that some users assume it's a built-in command. Long, long ago Cosmos provided it. In the Ace2 era, almost every Ace2 addon provided it. More recently, InDemand provides it. SlashIn has its own advantages: - Updated for Patch 5.0 and Mists of Pandaria. - Uses AddonLoader if you have it. Examples Say "hi" in...
Raid Leader's Note
|Nov 14, 2011
|Raid Leader's Note is a user interface that allow RLs to create their own notes for each bosses. Whenever dispatching works to raid members with an boss encounter, RL just needs to do some clicks to assign and send it to raid channels.
|Aug 07, 2015
|Fancy up the default AddOn List! Inspired by ACP by sylvanaar and it predecessors. BetterAddonList has the following enhancements: Shift-click the check box to "protect" an addon, preventing it from getting disabled. Move the panel. Search! Enabled addons with missing or disabled dependencies are shown in red. Load AddOn button is always shown for unloaded load on demand addons. Create sets that allow you to quickly enable or disable groups of addons. Including multiple sets in one allows you...
|Jun 25, 2015
|Warlords of Draenor finally introduces a new talent macro conditional! /cast [talent:4/1] Storm Bolt; [talent:4/2] Shockwave; [talent:4/3] Dragon Roar /cast [spec:1,talent:5/1] Nether Tempest; [spec:2,talent:5/1] Living Bomb; [talent:5/2] Unstable Magic; [spec:1,talent:5/3] Supernova; [spec:2,talent:5/3] Blast Wave; This should be enough for most people, however, as you can see with mages, it can get ugly when factoring in spec specific talents. Imagine if you also want to use a different...
|Feb 25, 2015
|Pops up a message and plays a sound when a vignette skull appears on the minimap. No options!
|Mar 30, 2013
|Quick Description Funksfont is created by Newfunk. It changes the font of your damage to make it look more sexy. Other Fonts in download tab. Features Changes the way your damage font looks Usage To make your damage a bit more funky. Download FunksFont Download Funk's MarioFont Download Funk's TriforceFont Download Funk's ZeldaWindwakerFont Download Funk's MoonmoonFont Funk's HalfdeadFont
Loot-a-Rang Matic
|May 05, 2015
|This addon uses your Loot-a-Rang when you double right click in the game world or if your a hunter and don't have a Loot-a-Rang it casts Fetch if you have the Glyph Loot-a-Rang Matic will not use your Loot-a-Rang when you are in a dig-site or have a fishing pole equipped unless you are hovering over a loot able corpse. Also do to Blizzard restrictions Loot-a-Rang Matic can not function while in combat or while moving.
|Oct 15, 2010
|Rep2 displays a message which shows how much reputation you gained, and how much is needed until the next standing, including fallover rep to secondary factions.
|Jun 25, 2015
|Automatically and immediately cancels all in-game cinematics and movies. CinematicCanceler ensures you are never stuck on a cinematic screen while important group events are taking place. In some cases can even prevent cinematic-related client crashes and freezes. Install as usual and It Just Works (tm). Will print a message to chat when a cinematic is suppressed. You can hold any modifier key (shift, control, alt) when a cinematic is starting to allow it to play.
|Jun 24, 2015
|Ever encounter a bug where UI buttons are not clickable or elements are mysteriously missing? This is usually caused by a bug in the Blizzard frame code, whereby child frames can accidentally be assigned a lower level in the frame strata than their parent, leading to buttons that appear "behind" their container, making them either unclickable or completely hidden. StrataFix provides a simple workaround for this bug, which affects numerous UI elements, notably including: Encounter Journal...
|Mar 30, 2015
|InspectFix is a tiny addon that fixes several annoying bugs that arise while using the Blizzard Inspect UI. If you like InspectFix, please check out the Blizzard Bug Fix Addon Pack! Overview The Blizzard API for performing character inspection has fatal design flaws (namely, it's stateful yet client-oblivious). All UI elements that perform character inspection, from the Blizzard inspect frame to many addons that perform hidden inspects for various purposes, are forced to use this same API and...
|Aug 05, 2015
|MACROCEPTION!!! WHAT DOES IT DO? Macroception allows you to call a macro from within another macro by its name. Currently only default UI macros can be called. Support for different custom macro AddOns is planned, though! I mean, maybe. HOW DO I USE IT? /click m macroName:mouseButton macroName The name of the macro to call. If this is a number, it will call the macro by its ID instead (which is not recommended as these tend to change, I think?). mouseButton (optional) Simulates this button in...
|Jul 02, 2015
|Inserts more than 25 additional fonts into SharedMediaLib's storage.
|Aug 23, 2015
|XPBarNone XPBarNone is an XP bar with handy feature set. Description Lightweight XP bar with a nice set of features, the text display is customisable, the default setting resembles the following: Exp: 1234/56789 (7586) :: 12.5% through level 34 :: 1234 XP left :: 12 kills to level Menus You can access two different menus to configure XPBarNone. Shift + Right Click: This accesses the main configuration menu. It's the same menu you could get through the slash commands, but in a nice graphical...
|Aug 23, 2015
|Adds a button to undress the model in the Dressing room, which makes viewing some items easier (eg. Checking out some new pants if you wear a robe).
|Oct 26, 2015
|Description LoggerHead is a an automated combat log enabler. It allows you to select via a simple GUI interface which Zones and Instances to automatically enable for logging. Works for PvP/Arenas(For real this time)! LoggerHead has a LDB module for those running a Data Display. Left Click toggles logging. Right Click opens configuration screen. Enjoy. Localization!!! I need help localizing LoggerHead to Latin American Spanish! If you want to help please check out:...
Shadowed Overseer
|Nov 26, 2014
|Garrison mission management
|Jan 11, 2016
|After every patch there are often a variety of bugs that crop up in the WoW UI. Many of them go largely unnoticed by users. AddOn authors have often made small addons to fix these problems. This addon intends to create a single installation for users that include whatever fixes the community can come up with for UI problems. As new issues and workarounds are discovered they will be added. As old issues get fixed they will be removed. Users benefit by having a single addon they can just keep...
|Jun 27, 2015
|SorhaFrameDrag is a utility addon inspired by FluidFrames. Move UI Frames When installed this addon allows you to freely drag frames such as the spellbook or character pane around. This doesn't save the positions of the frames, so no risk of losing a frame somewhere. Whenever you reopen the frame it opens in its default blizzard location Location Saving Modules Objective Tracker - Allows the movement and saving location of the blizzard Objective Tracker Alt Power Bar - Allows the movement and...
|Oct 17, 2014
|JHide provides you with the ability to show and hide other addons by calling scripts assigned to one of its 4 buttons. You can create scripts for other addons and assign them to a button of your choice. The tricky bit is finding a script that hides/shows the other addon :( Functionality: You click the buttons around the orb to show/hide addons individually. Clicking the orb will show or hide all addons. Typing /jh will open the options panel allowing frame movement, script creation etc....


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1 item from 2013
8 February 2013 7:55 AM, PST | The Guardian - Film News | See recent The Guardian - Film News news »
A Fake Moon rises over Bristol at the Ibt festival, Philip Pullman's I Was a Rat! scurries into Birmingham, and James McAvoy tackles the Scottish play in London
The big opening this week is Roger McGough's new version of Molière's The Misanthrope at Liverpool Playhouse, which should be fun. Theatre meets music gigs in 154 Collective's Dancing With the Orange Dog, which is at Stockton Arts Centre on Tuesday and Wednesday.
Hairspray is out on tour again and is at the Lowry in Salford. In Manchester, meanwhile, Queer Contact celebrates the best in Lgbt art and culture this weekend. The moving first-world-war drama, The Accrington Pals, continues at the Exchange. David Copperfield begins at the Oldham Coliseum tonight. This looks intriguing: at Haphazard at Z-arts on Saturday is Word of Warning's day of live art for all ages. The Edinburgh hit, Unmythable – all the Greek myths in 70 minutes »
- Lyn Gardner
1 item from 2013
IMDb.com, Inc. takes no responsibility for the content or accuracy of the above news articles, Tweets, or blog posts. This content is published for the entertainment of our users only. The news articles, Tweets, and blog posts do not represent IMDb's opinions nor can we guarantee that the reporting therein is completely factual. Please visit the source responsible for the item in question to report any concerns you may have regarding content or accuracy.See our NewsDesk partners


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Answers (0)
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News (29)
Pet Products (3)
Pet Products Reviews (11)
Pet Services (6)
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3 Results
Pet Products
Rating: 4.5
Average rating from 2 reviews.
The Aïkiou bowl is an interactive bowl designed to entertain animals during their meal time. Serving a second utility, it helps animals reduce their ingestion speed and brings out the instinct of search for their food.
Top Stories
We've all grown accustomed to the many fundraisers and charitable events that the pet industry produces for homeless pets. From pet food companies… more ›


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Even in San Francisco, where street violence by anti-war rioters goes unpunished, the gray hairs among these "demonstrators" (as the press calls them) speaks volumes about the generation gap.
But, make no mistake about it, the political left is in firm control on campus and in the media. Our students get a steady diet of the left-wing vision of the world from elementary school through graduate school. But sanity breaks through now and then, partly as a result of conservative talk radio and conservatives scattered here and there in the media, but more importantly because reality breaks through, especially when life and death are involved.
Most of the young do not yet have the intelligentsia's dexterity with words to deflect evidence and evade common sense. Even before this war began, the contrast between the people and the intellectuals was apparent. The terrorist attacks of September 11th filled most Americans with shock, anger, and resolve -- except for those among the intelligentsia who saw just another opportunity to make cleverly outrageous statements against the United States.
Being clever, daring, and morally one-up are very important to those who live by words -- certainly more important than being right, and more important than defending the society which makes their freedom possible and tolerates so much of their nonsense.
If nothing else, the time is long overdue to rethink tenure that allows such self-indulgence and "faculty self-governance" which has allowed the left to blackball those who do not share their ideology, in order to keep people with different ideas from teaching and breaking their classroom monopoly.
Creators Syndicate
Trump: If Ted Cruz doesn't stop cheating and attacking me, I have standing to sue him over his natural-born status | Allahpundit


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Card Making · Step By Steps · Floral Roses Various
Step by step designs are more commonly known as decoupage. They create a 3D effect by using multiple layers of the same image. We have Quick card fronts that have decoupage elements, as well as decoupage card toppers. Step by step cards are a very popular variety of handmade cards.


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JFK Website (0)
Digital Archives (1)
Title: District of Columbia: Lawson, Marjorie: NAACP, 1959: May-June
This folder contains a newspaper article and memoranda from campaign worker Marjorie M. Lawson to Senator John F. Kennedy and members of Senator Kennedy's staff concerning the Senator's meetings with various civil rights leaders with regards to the 1960 presidential campaign.
Search powered by Oracle Endeca ®.
JOHN F. KENNEDY PRESIDENTIAL LIBRARY AND MUSEUMColumbia Point, Boston MA 02125 (617) 514-1600


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can i get a police officer or detective to take care of this. they are also talking to my friends as if they were me and now my friends dont know what to trust wether they are talking to me or not. how do i get to the bottom of this
Personal Injury Lawyer
This is a violation of the terms of service for Facebook. You should report it to them right away. I believe they will act in that this is the type of abuse they want to stop.
Whether police will help is not something I can speculate about. If there is the potential for criminal action, they might get involved.
Report this to Facebook right away.
Start your own Facebook page and tell everyone what is happening.
Actual legal advice can only be provided in an office consultation by an attorney licensed in your jurisdiction, with experience in the area of law in which your concern lies.
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What is RM Cash
This is a "machine-selection optional" part.Please choose a vehicle to see products specific to your machine, select a product below.
User Tip: If you're unsure of your vehicle type, you may skip the machine type selection box.
Computers and speedometers that give you all the necessary information for rides and maintenance.
Anthony in CA
I feel its a must have if you purchase the Trail Tech Vapor computer. The mount can attach to the bar hold down clamp which places it up closer to the rider and more subject to potential damage but also direct sun which can wash out the screen when it gets hot, but will return when cooled. The better way is to locate it where the factory computer was located (have to remove it of course) and used some short stand-offs and bolts to mount it, so now its in the original computer location, protected from crash damage and protected from direct sun-light for the most part. I have not had any issue with the sun washing out the screen once I moved it to the factory location. The factory metal bracket below the OEM computer has to be slightly modified but the end result is awesome.Read All Reviews
Anthony in CA
Nice being able to keep a record of your total mileage and hours besides trip mileage and time, clock, air temp, coolant temp, set warning lights and RPM. Unfortunately my Tach does not read properly no matter what I've tried and even contacted CS at Trail Tech for assistance and followed their advice. So no accurate RPM on my bike but still worth the cost of admission for all the other features so 4 stars not 5 because of this.Read All Reviews
Steven in ND
I broke my stock one and was shock at the price of oem replacement so I tried this. Plugged right in and bolted right on stock mounting bracket. Best part of all is that it's nicer to look at and saved money.Read All Reviews
greg in PA
this computer works exactly as i hoped it would. the set up was very easy and straight forward. it comes with a magnetic caliper bolt which made setting the speedometer up a breeze!Read All Reviews
Kyle in OR
This truly is a kit. It comes with three different magnet bolts and one loose magnet and some zip-ties. However, it did not come with any nuts so I had to find my own.Read All Reviews
Nolan in WA
I have had really good success so far with this computer. It's nice to see your temp,mph,altitude,time. I can't say about the GPS yet, haven't downloaded any maps yet but if I have any problems I will update this review!Read All Reviews


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A west-side hotel was damaged by a fire that started in one of the rooms early Monday morning.
Several people called 911 shortly after midnight to report a fire in the 1200 block of South Freeway, near 22nd Street and Interstate 10, Capt. Chris Jurvig, a Tucson fire spokesman said in a news release.
When crews arrived they found heavy smoke coming from a first-floor hotel room and forced the door open, the release said.
Witnesses described flames as being up to 15 feet high.
Seventy people were evacuated from rooms near the fire, while crews worked to put out the blaze.
An adult, a child and two dogs were in the room when the fire started but got out safely.
The fire was brought under control within eight minutes and crews prevented the fire from spreading to other rooms, however several adjacent rooms had smoke damage, the release said.
The cause of the fire is still under investigation.


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Torture and Interrogation Tactics
Two House subcommittees held a joint hearing on "Rendition to Torture: The Case of Maher Arar." Testifying by remote… read more
Two House subcommittees held a joint hearing on "Rendition to Torture: The Case of Maher Arar." Testifying by remote connection, Mr. Arar, a Canadian, described being detained at JFK Airport and deported to Syria where he was imprisoned and tortured. Professor Roach testified by remote connection about a Canadian independent commission report which showed that Mr. Arar had committed no offenses. Other witnesses testified in the hearing room about the practice of extraordinary rendition, illegal interrogations, the Geneva Convention, and international law. close
People in this video
- Maher Arar Detainee
- Daniel Benjamin Senior Fellow and Director Brookings Institution->Center on the United States and Europe
- John "Russ" Carnahan U.S. Representative [D] Missouri
- David D. Cole Professor Georgetown University Law Center
- John Conyers Jr. U.S. Representative [D] Michigan
- William "Bill" D. Delahunt U.S. Representative [D] Massachusetts
- Keith Ellison U.S. Representative [D] Minnesota
- Trent Franks U.S. Representative [R] Arizona
- John Garcia Attorney Congressional Research Service->American Law Division
- Frederick P. Hitz Senior Fellow University of Virginia->Center for National Security Law
- Jerrold Nadler U.S. Representative [D] New York
- Kent Roach Professor University of Toronto->Law School
- Dana Rohrabacher U.S. Representative [R] California
Hosting Organization
Related Video
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Representative Franks spoke about a revision to the Foreign Intelligence Security Act which was the subject of a mark…
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Representative Nadler and Lungren talked about the Foreign Intelligence Surveillance Act (FISA), which was up for…
CIA Interrogation Tapes
Pamela Hess talked about the Central Intelligence Agency's destruction of videotapes that detailed the…
Destruction of Interrogation Tapes
Tim Starks talked about congressional investigations into the destruction of CIA interrogation tapes.


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specialegg by nucuWatch
©2009-2016 nucu
Great one!
i feel like eggs
oh, it's omelette moment. welcome!
very nice vector work in the glossy shine. and perfectly screams newegg, lol, i'll definitely be studying this for the next time i use gloss and shine, love the back pattern as well... a simple image that is surprisingly intricate, well done.
Ha-ha-ha. Nice.


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Jacob Transformation Stamp by sora1992Watch
©2009-2016 sora1992
Bit cruddy, but hey.
Gets the message across. XDD
Gets the message across. XDD
Jacob is Probably the Only Reason I Still Like The Franchise............Edward's A Stupid Excuse For A Man.
Even though I don't like twilight, this is both awesome AND true XD
So true XD
LOL yeah! xD
heck yes.
But acting like you're constantly PMS-ing is macho as fuck.
Even if I'm not a Twilight fan I've to say that this stamp is awesome! xD
XD "cuz real men dont sparkle" XD
luv it
luv it
True story xD
heeeeeeeeeeell yeaaah.
Charlotte during Demyx Time ... 12 you hit Zexions head against a whitebord for saying Twilight was literature
i thought twilight isnt literature XD
Real men don't pick sides in Twilight.
how do I put a stamp on my page?
Awwww que lindo Lobito ;3 , Yo soy team Edwuard
That's so true! 3
Jacob is so sexy I luv him! *-*♥
Jacob is so sexy I luv him! *-*♥
Yeah, i agreed...but real man, or werewolf in case, wear clothes and dont use steroids...and transform in one freaking second...
lolzs i like to ues this ^__^
Jacob is FIT lush gorg this is great
a sparkly bloodsucker or a pedophile dog? hmmmmm... hard election...
i love the quote: "real men don't sparkle"
I approve!!!!! Team Jacob!!!
Sparkles are for little girls.
LOL!!!!! Because Real Men Don't Sparkle. OMFG. I LUV IT.
He has no balls.
Honestly, I'm Team I-Don't-Give-A-Shit. c:
Honestly, I'm Team I-Don't-Give-A-Shit. c:
they dun sparkle but when they're hot then they shall sparkle ;D lol that's what mai friend would say XD but i completely support team jacob to the fullest! i'm not an intense fan girl i just respect him because he reminds me of... someone.
hehe true,one example of a person who's not a real man
-beast from beauty and the beast, I could have sworn he was ......something.not a fav of twilight but have to agree with this
-beast from beauty and the beast, I could have sworn he was ......something.not a fav of twilight but have to agree with this
I don't understand why people think his transformation is so amazing; today's cartoons have better animation than this~
It s awesome cuz its true!!!
dats funny
Real "men" also don't turn into wolves Sorry to break it to you.
Real MEN don't turn into wolves either.
damn right they dont sparkle!!!
As a vampyre, I've officially decided to support anything anti-Edward (real vamps don't F***** sparkle! unless of course it's made up of alot of small fires on our skin caused by sunlight.)
This is so true
Normal men also do not turn into wolves.
I'm not huge twilight fan but I like Jacob


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The Man Who Changed Our Language and Brought the Bible to Wales; Ian Parri Marks the 400th Anniversary of the Death of Bishop Morgan, the Man Responsible for the Linguistic and Religious Landscape of Wales Today
Byline: Ian Parri
IT might seem somewhat remiss, given the great man's stature, but no-one knows for certain where the remains of the literary genius credited with keeping Welsh a living language were interred. Not to mention his introduction of the famous `ll' digraph into Welsh orthography that still perplexes some tongue-twisted visitors to this day, so that the unfamiliar looking Lhangolhen became modern-day Llangollen.
Four hundred years ago this week, the body of Bishop William Morgan was committed to the earth somewhere in St Asaph Cathedral, beneath the bishop's throne, according to some. However a fine memorial in the grounds erected in 1892 commemorates his contribution and that of the other pioneers who worked on translating the Bible into Welsh.
Historians largely agree that his contribution was rather more than just to the nation's religious, cultural and linguistic heritage, great as that was.
The publication of the Welsh Bible in 1588 held the nation together at a time when it seemed it could soon disintegrate as a separate entity.
Without his contribution, we would be seen as no more separate from England than Cornwall is today.
Our very identity was under pressure from the Act of Union passed just 52 years earlier, which sought to make Wales part of England in governance, thought, deed, education, allegiance to the English crown, language and religion.
Elizabeth I ordered that the Bible be translated into Welsh in 1563, although just 27 years earlier the language had been decreed to be a ``sinister usage and custom'' which was to be ``extirpated from the land''.
Television historian Dr John Davies, author of the 1993 volume History Of Wales, says that this unexpected U-turn by the English authorities was forced on them by circumstances.
``When you think of the troubles that blighted the 16th century, the civil war between the Protestants and the Catholics in France, Germany, the Netherlands, Spain and Hungary, you can see that what was really important was unity on the question of faith, '' he says.
``It was more important than linguistic unity, although the Act of Union in 1536 decreed that English was to be the only official language of England and Wales. The authorities, however, were willing to compromise on that.
``Commentators from the time noted that the Welsh were still very superstitious and followed old Catholic practices.
``There was great concern that the Welsh would adhere to these practices, exactly as happened in Ireland.
``The Irish were a constant thorn in the establishment's side and they certainly didn't want the Welsh to follow suit.
``From the point of view of the English authorities, what they invested in translating the Bible proved to be much cheaper than keeping the Welsh under control. ''
One of the main reasons that the work of Bishop Morgan is considered so important is that it was the first complete Welsh-language Bible.
In the absence of varied secular literature, the Bible also came to play a disproportionate role in the development of the language. …


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That Jackie Robinson and Branch Rickey were Republicans when they shattered baseball's color barrier in 1947 is only surprising if you consider the changed GOP – after its Southern Strategy and unsubtle appeals to racism, leading to demonizing the first black president. But there was this other principled GOP, says Independent Institute's Jonathan Bean.
The Scandal of Lax Government
For decades now, it's been fashionable to demonize government. After all, that's what billions of dollars invested in right-wing think tanks and media outlets will buy you. There also are genuine abuses by bureaucrats. But lax government oversight can be a scandal, too, as Bill Moyers and Michael Winship note.
Does Woodward Know Watergate?
Exclusive: Republicans are hyping the flap over Benghazi talking points by calling it "worse than Watergate," a false narrative that Bob Woodward has helped along by ignoring new evidence connecting Richard Nixon's sabotage of Vietnam War peace talks in 1968 to his political spying in 1971-72, writes Robert Parry.
Failing Fitzgerald's Masterpiece
Exclusive: As an author, F. Scott Fitzgerald was a master of subtlety in his characterizations and his style, not exactly the strengths of modern Hollywood, as is painfully apparent in the latest big-budget, 3-D adaptation of The Great Gatsby, as Jim DiEugenio explains.
Reagan and Argentina's Dirty War
Exclusive: The 87-year-old ex-Argentine dictator Jorge Videla died Friday in prison where he was serving sentences for grotesque human rights crimes in the 1970s and 1980s. But one of Videla's key backers, the late President Ronald Reagan, continues to be honored by Americans, writes Robert Parry.
Boston Suspect's Writing on the Wall
Exclusive: Hiding and near death, Boston Marathon bombing suspect Dzhokhar Tsarnaev reportedly scrawled on the inside of a boat that he did what he did to avenge innocent Muslims killed by U.S. wars in Iraq and Afghanistan, a rare look at the why behind "terrorism," writes ex-CIA analyst Ray McGovern.
The Sad Lesson of Alan Hart
Sailing against a strong prevailing wind is not easy, certainly not like breezing along with the wind to your back. Author Alan Hart discovered that truth in criticizing Israel's treatment of the Palestinians, but his acceptance of defeat should not stop others from advocating for truth and justice, says Lawrence Davidson.
The Lost 'Trifecta of Scandals'
From CNN to the Washington Post, the mainstream news media is abuzz about "the trifecta of scandals" besetting the Obama administration, a narrative that fails to assess the actual significance of the three "scandals." They don't measure up to the many important scandals that the media neglects, says Beverly Bandler.
Missing the Bigger IRS 'Scandal'
The Washington press corps is in hot pursuit of "Obama scandals," stampeding officials into various rushes to judgment while missing the bigger scandals underlying the excitement du jour, such as the systematic abuse of federal tax-exempt status for secret political donations, as William Boardman notes.
The Right's 'Scandal' Funhouse Mirror
Exclusive: Official Washington is captivated by the image of Obama "scandals," including Benghazi talking points and extra IRS questions posed to Tea Party groups, but journalists are peering into the Right's funhouse mirror which for decades has made big scandals small and small scandals big, says Robert Parry.


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Are you Daniela Vandresen Pilonetto?Claim your profile
Publications (8)22.68 Total impact
Article: Excellent Outcome for Fanconi Anemia Patients Undergoing Hematopoietic Stem Cell Transplantation (HSCT) without Radiation: A Single Center Experience on 103 Patients
Article: Unrelated Bone Marrow Transplantation (UBMT) for Children and Adolescents with Fanconi Anemia (FA) Using Cyclophophamide, Fludarabine and Rabbit ATG: Analysis of 33 Patients Transplanted at a Single Institution
- [Show abstract] [Hide abstract]
ABSTRACT: Tumor necrosis factor alpha (TNF-alpha) production is abnormally high in Fanconi anemia (FA) cells and contributes to the hematopoietic defects seen in FA complementation group C-deficient (Fancc(-/-)) mice. Applying gene expression microarray and proteomic methods to studies on FANCC-deficient cells we found that genes encoding proteins directly involved in ubiquitinylation are overrepresented in the signature of FA bone marrow cells and that ubiquitinylation profiles of FA-C and complemented cells were substantially different. Finding that Toll-like receptor 8 (TLR8) was one of the proteins ubiquitinylated only in mutant cells, we confirmed that TLR8 (or a TLR8-associated protein) is ubiquitinylated in mutant FA-C cells and that TNF-alpha production in mutant cells depended upon TLR8 and the canonical downstream signaling intermediates interleukin 1 receptor-associated kinase (IRAK) and IkappaB kinase-alpha/beta. FANCC-deficient THP-1 cells and macrophages from Fancc(-/-) mice overexpressed TNF-alpha in response to TLR8 agonists but not other TLR agonists. Ectopically expressed FANCC point mutants were capable of fully complementing the mitomycin-C hypersensitivity phenotype of FA-C cells but did not suppress TNF-alpha overproduction. In conclusion, FANCC suppresses TNF-alpha production in mononuclear phagocytes by suppressing TLR8 activity and this particular function of FANCC is independent of its function in protecting the genome from cross-linking agents.
- [Show abstract] [Hide abstract]
ABSTRACT: Fanconi anemia is a rare hereditary disease showing genetic heterogeneity due to a variety of mutations in genes involved in DNA repair pathways, which may lead to different clinical manifestations. Phenotypic variability makes diagnosis difficult based only on clinical manifestations, therefore laboratory tests are necessary. New advances in molecular pathogenesis of this disease led researchers to develop a diagnostic test based on Western blot for FANCD2. The objective of the present study was to determine the efficacy of this method for the diagnosis of 84 Brazilian patients with Fanconi anemia, all of whom tested positive for the diepoxybutane test, and 98 healthy controls. The FANCD2 monoubiquitinated isoform (FANCDS+/FANCD2L-) was not detected in 77 patients (91.7%). In 2 patients (2.4%), there was an absence of both the monoubiquitinated and the non-ubiquitinated proteins (FANCD2S-/FANCD2L-) and 5 patients (5.9%) had both isoforms (FANCD2S+/FANCD2L+). This last phenotype suggests downstream subtypes or mosaicism. All controls were diepoxybutane negative and were also negative on the FANCD2 Western blot. The Western blot for FANCD2 presented a sensitivity of 94% (79/84) and specificity of 100% (98/98). This method was confirmed as an efficient approach to screen Brazilian patients with deleterious mutations on FANCD2 (FANCD2S-/FANCD2L-) or other upstream genes of the FA/BRCA pathway (FANCDS+/FANCD2L-), to confirm the chromosome breakage test and to classify patients according to the level of FA/BRCA pathway defects. However, patients showing both FANCD2 isoforms (FANCD2S+/FANCD2L+) require additional studies to confirm mutations on downstream Fanconi anemia genes or the presence of mosaicism.
Article: Stem cell transplantation in 40 pts with Fanconi anemia (FA): Excellent survival and low toxicity for pts with a related HLA identical donor
Article: Frequency of Fanconi anemia in Brazil and efficacy of screening for the FANCA 3788-3790del mutation[Show abstract] [Hide abstract]
ABSTRACT: Fanconi anemia (FA) is an autosomal recessive genetic disease characterized by progressive bone marrow failure, susceptibility to cancer and multiple congenital anomalies. There is important clinical variability among patients and the knowledge of factors which might predict outcome would greatly help the decision making regarding the choices of treatment and the appropriate time to start it. Future studies of the possible correlation between specific mutations with specific clinical presentations will provide the answer to one of these factors. At our Center we standardized a rapid and precise screening test using a mismatch PCR assay for a specific mutation (3788-3790del in exon 38 of gene FANCA) in Brazilian FA patients. We present the results obtained after screening 80 non-consanguineous FA patients referred from all regions of Brazil with a clinical diagnosis of FA supported by cellular hypersensitivity to diepoxybutane. We were able to detect the 3788-3790del allele in 24 of the 80 (30%) FA patients studied. Thirteen of the 80 (16.25%) were homozygotes and 11 of the 80 (13.75%) were compound heterozygotes, thus confirming the high frequency of the FANCA 3788-3790del mutation in Brazilian FA patients. The identification of patients with specific mutations in the FA genes may lead to a better clinical description of this condition, also providing data for genotype-phenotype correlations, to a better understanding of the interaction of this specific mutation with other mutations in compound heterozygote patients, and ultimately to the right choices of treatment for each patient with improvement of the prognosis on future studies.
Book: Pilonetto, Marcelo, and D. V. Pilonetto. "Manual de procedimentos laboratoriais em microbiologia." Curitiba: Microscience (1998).
Article: Diagnóstico laboratorial da Anemia de Fanconi: análise da via de interação das proteínas AF/BRCA por meio da detecção da proteína FANCD2 e de sua forma monoubiquitinada pelo Método de Western Blot/[Show abstract] [Hide abstract]
ABSTRACT: Orientador: Ricardo Pasquini Co-orientadoras: Neiva Isabel Rodrigues Magdalena, Noemi Farah Pereira Apêndices e anexos Dissertação (mestrado) - Universidade Federal do Paraná, Setor de Ciências da Saúde, Programa de Pós-Graduação em Medicina Interna e Ciências da Saúde. Defesa: Curitiba, 11 de julho de 2007. Inclui bibliografia Área de concentração: Medicina Interna
Top Journals
Universidade Federal do Paraná
Curityba, Paraná, Brazil
- Hospital de Clínicas
Federal Technological University of Paraná - BrazilCurityba, Paraná, Brazil


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PERRY COUNTY - Perry County residents will get opportunities Friday and Saturday to clean out their medicine cabinets and safely dispose of unwanted drugs and used hypodermic syringes for free.
The items will be collected from 8 to 10 a.m. June 11 at the Perry County Family Practice Clinic at the intersection of Indiana 37 and French Ridge Road. Another collection will be conducted from 8 a.m. until noon June 12 at the Tell City Fire Department, 12th and Mozart streets.
TELL CITY - The JFK Tell City Pool is now open for the summer 2010 season. Pool hours will be 11 a.m. to 6 p.m. Monday through Saturday and noon to 5 p.m. Sundays.
Admission will be $2.50 for ages 5 and older. Guests ages 4 and younger are admitted free.
Public lessons will be offered starting June 15. Lessons will be offered every Tuesday and Wednesday. Lessons will be either from 10 to 10:45 a.m. or 6 to 6:45 p.m.
Price of eight lessons is $40 for the first child, $35 for the second, $30 for the third and so on.
LEOPOLD - The Perry County Relay For Life committee invites cancer survivors of all ages to the survivor luncheon Saturday to kick off the Perry County Relay For Life.
The meal will be served at noon with photographs being taken afterward courtesy of Danny Bolin Photography.
For more information regarding the luncheon or to RSVP contact Jamie Smith at 836-4577, Pam Krygielka at 836-2712 or Gail Edwards at 843-5233.
TELL CITY - The Tell City Historical Society has voted to accept public nominations for its Distinguished Citizen Award.
Since the 1960s, a distinguished member of the community has been honored during the Schweizer Fest for their contributions to the betterment of Tell City.
The following criteria are considered in determining the honoree:
• An individual who has accepted Tell City as his or her home, whether by birth or adoption, and has benefited the community.
TELL CITY - The City of Tell City and the Perry County Chamber of Commerce announce the opening of the Perry County Farmers Market, beginning at 2 p.m. Wednesday. The market will be located at the Jefferson Street entrance of City Hall Park in Tell City.
The market will be open each Saturday at 7 a.m. and Wednesday at 2 p.m. An invitation goes out to all Perry County farmers and the public to the market.
INDIANAPOLIS - The Perry County Department of Child Services will implement the services of a centralized call center June 21.
The Indiana Child Abuse and Neglect Hotline directly answers reports of child abuse and neglect around the clock. The hotline staff has received specialized intake training and responds to allegations of abuse or neglect and addresses questions of callers to the hotline.
Implementation of a centralized hotline system began in Marion County in January and will continue to roll out on a regional basis.
TELL CITY - A blood drive Thursday in Tell City will honor fallen officers. The event will be held from 3 to 7 p.m. at American Legion Post 213.
This is the fourth year the Red Cross will host blood drives across the state to honor fallen officers and raise awareness of the need for blood. In 2009 every county in the state held at least one Fallen Officer Blood Drive and a total of 4,980 units were collected.
For more information on the event or donor requirements, call (800) 448-3543.
PERRY COUNTY - New interpretive panels at six locations in Perry County offer residents and visitors historical snapshots of local history and culture. The panels are among 68 placed along the Hoosier portion of the Ohio River Scenic Byway, a 943-mile stretch of roadways in Ohio, Indiana and Illinois. The route follows Indiana 66 in Perry and Spencer counties.
If you're a voter, you'll be asked in November if you want to help change the Indiana Constitution.
Property-tax caps that have been the subject of numerous news stories, several here and many elsewhere, survived the first of the steps, in 2008 and this year, required to get them into the state's most important document.
Step 3 is yours to handle, as a voter in November's election.
I didn't recognize the guy in the pickup truck and while he didn't seem to pay much attention to the activities under way in City Hall Park May 30, his innocent drive-by on the Sunday before Memorial Day helped me. He left me with a new understanding of just how lucky we are to live in a nation where we can do pretty much what we want.
Copyright © 2016
The Perry County News is your source for local news, sports, events, and information in Perry County, Indiana, and the surrounding area.


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Maybe it is a problem with my host server, and maybe this isn't something that can be handled within the WordPress "engine", but I'm almost always timing out (returns a page 404 not found) when I hit the save or publish on most of my long posts, especially those with html in them. Long posts specifically, not short ones. I've had the same problem with 1.2 and 1.5.
When the SAVE or PUBLISH is clicked, I believe WordPress goes through and cleans things up, so maybe this is where the time out to a 404 occurs. Ideas?


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We booked this place initially only for 2 nights and ended up staying 4 (nights). This place is 50 meters from the UNESCO heritage city center of Paraty. The rooms are clean with aircon, the breakfast is very nicely done. We used to go down to the ground floor and chill out on the sofa in the common area. We... More
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