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I am at a loss as to what to do here...
Up until last Thursday my baby was tranverse, back down (worst possible positioning scenario). The doctors pressured me big time to schedule a c-section for last Friday. When I went in Thursday, the baby had moved into a breech position. I told them if there was a 1% chance she will get out of breech and be able to be born naturally, I wanted to give her more time. Their big solution was to schedule c-section for this Monday.
My EDD is 2/17 and this is my first. I just can't wrap my head around why they are trying to force me into having a c-section before her actual due date. (I got it in the transverse position, because that would have required a 2-cut, higher risk procedure.)
This baby is still really active and she's already proven them wrong by getting out of her tranverse position. Plus, she's my first.
At this point, I want to cancel the c-section for Monday and not "schedule" anything until at least her EDD. I know my doctors will not support this. Thoughts?
Ok, so I went ahead and went to L&D on Monday morning for the c-section as scheduled. Right before they wheeled me to the OR, the doctor did a manual check and then scanned me. Guess what- my little had turned head down!!!
I was sent home and am now anxiously awaiting natural labor- EDD is tomorrow. My husband and I feel so blessed!


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flipper1966 70+, M 4 Answers 0 Aug 17, 2014 in Doing Good
Yes, and so does the "a" key on everyone's keyboard!
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Give one example of how can you contribute/help a little to our environment... as we experiencing now .. (Global WarmingTo help mitigate climate change... do ur part as we live in one common planet so called our Mother Earth.. Go Green!toppaye 26-30, M 7 Answers 1 Nov 9, 2013 in Doing Good
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According to the new "ABC News" poll on health care, Americans are eager to have the government force employers to provide heath insurance: "Nearly eight in 10 favor a federal requirement that all employers offer insurance to their full-time workers."
Why?! Do our employers pay for our food, clothing, or shelter? If they did, why would that be good? Having my health care tied to my boss invites him to snoop into my private health issues, and if I change jobs, I lose coverage.
Employer-paid health insurance isn't free. It just means we get insurance instead of higher salaries. I'd rather have the cash and buy my own insurance. Companies only provide it because of a World War II-era tax break that never went away.
But people think it's something for nothing. In Maryland, the legislature even tried to single out Wal-Mart for a special employee health-insurance mandate. Luckily, the courts struck down that law. It would have some cost workers their jobs, and all of them would have been paid less.
Anyway, insurance is a terrible way to pay for things. It's expensive and wasteful. Some years ago, an insurance CEO said that it costs $35-$50 to process a $25 claim.
Insurance burdens us with paperwork, invites cheating, and, worst of all, creates a moral hazard that distorts incentives. The first question people ask a doctor who recommends a test is not "Do I really need that?" but "Does my insurance cover it?" Insurance raises costs by insulating consumers from medicine's real prices.
Suppose you had grocery insurance. With your employer paying 80 percent of the bill, you would fill the cart with lobster and filet mignon. Everything would cost more because demand would rise and supermarkets would stop running sales. Why should they -- when their customers barely care about the price?
Suppose everyone had transportation insurance. The roads would be crowded with Mercedes. Why buy a Chevy if your employer pays?
We have gotten so used to having "other people" pay for most of our heath care that we routinely ask for insurance with low or no deductibles. This is another bad idea.
Suppose car insurance worked that way. Every time you got a little dent or the paint faded, or every time you bought gas or changed the oil, you'd fill out endless forms and wait for reimbursement from your insurance company. Gas and mechanic's prices would quickly rise because service stations would know that you no longer cared about the price. You'd become more wasteful: jackrabbit starts, speeding, wasted gas. Who cares? At most you're paying 20 percent of the bill.
Bernie Sanders Champions YUGE Profits for U.S. Corporations (But Only in Cahoots with Communists) | Humberto Fontova
Bush mocks Rubio and his fans: Stop whining that it's "unfair" that you're being attacked by another candidate's Super PAC | Allahpundit


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Washington, June 28, 1962, 8:58 p.m.
793. Eyes only Clough. In connection with the statements made at his press conference yesterday the President wishes you to convey to Chiang Kai-shek his strong feeling that is of utmost importance that both the United States and the GRC avoid giving the appearance of contemplating any aggressive action against the mainland at this time. Unless we both agree that conditions justify it we are not prepared to take action and therefore we must not appear aggressive. Invasion at this time obviously would not be successful and it is important that the Communists be regarded as the aggressors. Any departure from this principle can only play into the hands of the Communists by weakening our international position in the defense of Quemoy and Matsu and make us appear to be the instigators of military action. This can only complicate our position no matter which way the situation develops in the future.
Use your discretion whether to delay delivery of this message until the arrival of Ambassador Kirk.1Clough replied in telegram 1 from Taipei, July 2, that he was unable to see Chiang, who was recovering from surgery, and was therefore waiting for Kirk to deliver the message directly. (Ibid., 611.93/7-262)


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Patriots Daily Briefing 08.04.11
Good morning. Here is your PDB for Thursday, Aug. 4, 2011. It contains all the links, info, analysis and occasional humor that you'll need to go about your day. If you can't detect sarcasm or take yourself and/or football too seriously, this may not be your thing.
- 4:30-7:30 p.m., Practice.
- 1:30-4 p.m., Practice
- ProFootballTalk.com reported the Patriots are $9.2 million under the cap, but that was as of Tuesday. That figure likely includes the $3 million veteran exception, but probably doesn't include Matt Light or BenJarvus Green-Ellis. They are probably closer to $4.5 million under the cap right now. Of course, the Patriots could open up even more cap room by getting a long-term deal worked out with guard Logan Mankins.
Remember that teams don't spend right up to the cap to start the year. You still need room if you want to give out extensions to, for example, Wes Welker or Jerod Mayo.
And any restructures with Chad Ochocinco (likely) or Albert Haynesworth would also clear up room, but wouldn't happen until after the CBA is ratified.
- CB Ras-I Dowling couldn't go back-to-back practices after signing, and RB Shane Vereen was injured halfway through last night. Not a good couple of days for the rookies. You don't want to sign late and then get hurt. That really gets you off on the wrong foot.
- Dan Shaughnessy can't wrap his mind around Chad Ochocinco's group hug with the media. Yeah, neither can I. For the record, I abstained. There's no cheering in the press box, and there's definitely no hugging.
- I took a look at the evolution of the Patriots' defense. Right now we have only circumstantial evidence about any potential shift, but it's certainly interesting (I'll have some numbers in a follow-up blog post).
- RB BenJarvus Green-Ellis is back in the fold.
- Shaughnessy and Bob Ryan debate Albert Haynesworth.
- Training Camp Today looks at Matt Light's return.
- Shalise delivers the mail.
- The Rundown on last night's shells practice. Ochocinco is making strides.
Here's the tally so far:
PATRIOTS--Additions: WR Chad Ochocinco (trade), DE Albert Haynesworth (trade), DL Steve Williams, OL Jonathan Compas, OL Chris Morris. Re-signings: LT Matt Light, LG Logan Mankins, RB Sammy Morris, RB Kevin Faulk, LB Tracy White, S Brandon McGowan. Subtractions: OLB Tully Banta-Cain, DB Tony Carter, DL Marcus Stroud, DL Ty Warren, TE Alge Crumpler, OL Nick Kaczur, LB Anthony Leonard, LB Ryan Coulson, QB Jonathan Crompton.
JETS--Additions: WR Plaxico Burress, P Chris Bryan (Bucs), CB Donald Strickland (Chargers). Re-signings: CB Antonio Cromartie, WR Santonio Holmes, RT Wayne Hunter, S Eric Smith, K Nick Folk, T Robert Turner, QB Mark Brunell, S Brodney Pool. Subtractions: WR Brad Smith (Bills), OL Damien Woody (retirement), CB Will Billingsley (waivers), G Marlon Davis (waivers), P Steve Weatherford (Giants), CB Drew Coleman (Jaguars), OLB Jason Taylor (Dolphins).
DOLPHINS: Additions: RB Reggie Bush (trade with Saints), LB Jason Trusnik (Browns), QB Matt Moore (Panthers), LB Kevin Burnett (Chargers), DL Ronald Fields (Broncos), LB Jason Taylor (Jets), OT Marc Colombo (Cowboys). Re-signings: DL Tony McDaniel. Subtractions: QB Tyler Thigpen (Bills), LB Channing Crowder, LB Tim Dobbins.
BILLS: Additions: QB Tyler Thigpen (Dolphins), WR Brad Smith (Jets), DL Lionel Dotson (Dolphins), LB Nick Barnett (Packers). Re-signings: CB Drayton Florence, LB Garrison Sanborn, TE Scott Chandler. Subtractions: LB Paul Posluszny (Jaguars).
Further reading...
- RB Shonn Greene is ready to step it up. Bet you've never heard that one before.
- Rex Ryan is still saying UMass product Vlad Ducasse "is going to be a tremendous player." Is Vegas taking action on this? Please?
- Ravens WR Derrick Mason will visit the Jets. Why do they feel the need to replace Jerricho Cotchery?
- Former Colts OC Tom Moore views himself more as an observer with the Jets.
- S Brodney Pool is back. I have no idea what this means.
- The Jets only offered DE Shaun Ellis one year at the minimum? The Patriots should get in on that. Ellis kicked their ass last season, and they had to double him when he didn't. Would be a great third-down replacement for Vince Wilfork. At the least the Patriots could drive up the price for the Jets to keep Ellis.
- Kory Sheets doesn't want people to view him as just a third-down back. Uh, Kory, some of us don't view you at all. Who are you again?
- Vernon Carey took a pay cut and his moving to guard to make room for Marc Colombo.
- Coach Tony Sparano said it made him sick when fans chanted for Kyle Orton. That joke is too easy to make.
- Dave Hyde, you know I love you, but you can't be writing Brett Favre-to-the-Dolphins columns. Come on man!
- Jay Glazer reported Tiki Barber worked out for the Dolphins.
- Apparently the Bills are sticking with the 3-4. Rookie Marcell Dareus would played left, Kyle Williams in the middle and Dwan Edwards (RE) would be the starting line. Corner is the area with the most competition so far in camp.
- Thought that with Dareus and Williams, the Bills might go to the 4-3 -- they'll end up being a hybrid -- especially with former Dolphins coach Dave Wannstedt now on the staff.
"My role is to help Chan and George Edwards and the other guys on defense," said Wannstedt, who is also the inside linebackers coach. "Anyway that I can contribute defensively, that's why I'm here and that's my motive. Chan and I have such a good rapport that the two of us can talk about it and hopefully I can give him some thoughts on past experiences that help. My approach is that I've kind of done it all, so wherever I can be the most assistance, I'm ready to go."
During Wannstedt's 16 years in the NFL, his teams have ranked among the top 12 on defense 11 of those years, though they were all 4-3 teams. The Bills are professing to be a 3-4 base team, though they will sprinkle in some 4-3 as well, an idea that Wannstedt likes.
"As long as we continue to not try to do everything, taking a small section of the 3-4 and a small section of the 4-3 and working those things and getting really good at it, it's good and it can be done," he said. "The key to defense is not making mistakes, being aggressive, and giving your players chances to make plays."
- RIP, Bubba Smith.
- When the CBA is done today, Roger Goodell will have still have control of the conduct policy, Adam Schefter reported.
- Eagles DT Mike Patterson is doing fine after his on-field seizure.
- This Osi Umenyiora thing isn't done yet.


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Daily Jolt -- Lent Calendar Special
Click this banner to return to the Fast Pray Give Lent Calendar
To get Fast Pray Give challenges the night before, visit our Facebook fan page.
March 26th, 2014If I were to say, "God, why me?" about the bad things, then I should have said, "God, why me?" about the good things that happened in my life. — Arthur Ashe
FAST from complaining.
PRAY to see God in all things today.
GIVE away five things that you don't need.
After Lent, tune in to BustedHalo.com every day for our Daily Jolts and MicroChallenges!
Return to the Lent calendar.
Please note that the editorial staff reserves the right to not post comments it deems to be inappropriate and/or malicious in nature, as well as edit comments for length, clarity and fairness.


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|The Galactic Expo promotes education and awareness of holistic health,
natural healing, conscious living, and spirituality.
Our purpose and mission is to be of service
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One way we do this by connecting people, ideas, concepts, and
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Upcoming October Events
Our students have been busy preparing for these performances and we hope you will join us! All events are FREE and OPEN to the public!
Our students have been busy preparing for these performances and we hope you will join us! All events are FREE and OPEN to the public!
The Sunday, October 25 deadline for the CCE Spring Internship Programs to intern in the arts, start-ups, civic engagement field or to work remotely is fast approaching.
Sample of CCE Spring Internship Positions:
Come visit the Berick Center for Student Advising during our Family Weekend Open House on Friday, October 16 from 1:00-3:00 p.m. in 403 Lerner. Meet with Advising Deans, browse the CSArts Fall 2015 Exhibit, learn more about advising at Columbia and enjoy some light refreshments.
If you are a SEAS or a College senior majoring in a science, economics, math, or statistics, then you may be interested in the express application process for Masters degrees in the School of Engineering and Applied Science. Please join us for an info session on Thursday, November 5, from 10:00 a.m. - 11:00 a.m. and 3:00 p.m. - 4:00 p.m. in the Davis Auditorium.
Please RSVP
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Wednesday, October 21
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Center for Career Education Conference Room
East Campus, Lower Level
Friday, October 16
1:00-2:00 p.m.
343 Mudd
There will be a program overview and several current students available for any questions. James Ihn will also be in attendance to field any questions.
Light refreshments provided.


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I would like to think that this simple request for equality will be honored by the parade administrators. The fact that they were ignored by the Town Council two years ago should have all mothers in this town asking " what's up with that???" I hope Regina French and her Girl Scout troop continue to make a difference and show all girls that backing down is not an option. Good job Girl Scouts!
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Girl Scouts Seek To Change Memorial Day Parade Order
The Junior Girl Scouts of Troop 20549 are working on their Government in Action badge, and they came to the Town Council meeting on Monday night to put some of what they had learned in action. They asked the Council to change the order of march in the Memorial Day parade so that Girl Scouts can walk up front with the Boy Scouts of the same age, and not at the end of the parade with younger Scouts.
Two years ago, the leader of the F.N. Brown-based troop, Regina French, came before the Town Council to ask if older Girl Scouts could lead the parade with their counterpart Boy Scouts, but the parade order was not changed. She shared that with her troop recently as they were working on the government badge and they decided to bring the matter to the Town Council again. Angelina Guarducci read this statement on behalf of the girls:
Mayor Manley and members of Verona Town Council: I am a Junior Girl Scout in Troop 20549 from F.N. Brown School, 4th Grade.
My troop has marched in the Memorial Day Parade since we were in Kindergarten. After the parade, we are honored to place flags for the soldiers.
My troop and I are here today to ask you to allow the Girl Scouts to march alongside the Boy Scouts of the same age in the Verona Memorial Day Parade.
We found out that the policeman in charge at the parade has a list and it says that the older Boy Scouts go in front. All the Girl Scouts (even the older ones) must march with the younger kids toward the end of the parade.
We would like to ask you to please treat the Girl Scouts as equals and let them march alongside the Boy Scouts. It's only fair.
After Guarducci's remarks, French tried to remind the Council of her appearance two years ago and was cut short by Verona Town Manager Joe Martin. Martin said today that Sue Neale, who arranges the parade order, was talking to the Verona Police Department about changes. The Memorial Day parade steps off from Everett Field on Monday, May 26, at 10 a.m.
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4 Comments
Amelia Earhart, Margaret Thatcher, Admiral Grace Hopper, would all be up front in the parade.
Just wanted to give an update. I am a Brownie Girl Scout Leader – as we were lining up for the parade – the cub scout leaders came up to us and said: "Ladies would you do us the honor of walking in front of us?" We thanked them and obliged. They are a true class act. That being said,why didn't the town honor us equally? Our goal was not to walk before the Cub Scouts (and we do truly appreciate what they did)our goal was to walk beside them and be recognized by our town leaders as equals. Why did our town representatives turn their backs on Troop 20549 request?
Correction, seems Town did move Girl Scouts up. Still though we applaud the Boy Scouts for offering us the front spot before knowing the council's decision.
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Book your room at La Casona de Yaiza
Get an overview of this hotel3-star hotel with free breakfast and restaurant
Collect 200 points
Simply enter your Nectar card number when prompted. Your points will be credited 30 days after you return from your trip.*Offers may apply
Situated in Yaiza, this hotel is within 9 mi (15 km) of Quemada Beach, Timanfaya National Park, and Whale and Dolphin Museum. Los Hervideros Caves and Lanzarote Golf Resort are also within 12 mi (20 km).
Hotel Features
A restaurant, a poolside bar, and a seasonal outdoor pool are available at this hotel. Free buffet breakfast and free WiFi in public areas are also provided. Other amenities include tour/ticket assistance.
Room Amenities
All rooms are individually decorated and offer hair dryers and safes. Cable TV and showers are among the other amenities available to guests.Information missing or incorrect? Tell us!Opens in a new window
Hotel Amenities
Hotel Amenities
The hotel offers a restaurant. A poolside bar is on site where guests can unwind with a drink. Guests can enjoy a complimentary breakfast each morning. High-speed wireless Internet access is complimentary.
This Yaiza hotel also offers a seasonal outdoor pool and tour/ticket assistance.
- Total number of rooms - 8
- Number of floors - 2
- Free breakfast
- Front desk (limited hours)
- Tours/ticket assistance
- Free WiFi
- Poolside bar
- Restaurant
- Pool sun loungers
- Free parking nearby
- Year Built 1825
- Number of buildings/towers - 1
- Outdoor seasonal pool
Family Friendly Amenities
- Family Hotel
- Free Wi-Fi
- Rollaway/extra beds available
- Cribs/infant beds (complimentary)
Available in some public areas: Free WiFi
Free parking nearby
Room Amenities
- Air conditioning
- Hair dryer
- Shower only
- In-room safe
- Rollaway/extra beds available
- Blackout drapes/curtains
- Cable TV service
- Free cribs/infant beds
- Individually decorated
Where to Eat
A complimentary buffet breakfast is served each morning between 8:30 AM and 10:30 AM.
La Casona de Yaiza - This restaurant specializes in fusion cuisine and serves lunch and dinner. Open select days.
Hotel Policies
Check-in time starts at 11:00 AM
Special check-in instructions:
Check-out time is 11:00 AM
Payment types
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
- No onsite parking is available.
No pets or service animals allowed
Hotel Name
- Casona Hotel Yaiza
- Casona Yaiza
- La Casona De Yaiza Hotel Yaiza
- La Casona De Yaiza Lanzarote
We should mention
Cash transactions at this property cannot exceed EUR 2500, due to national regulations. For further details, please contact the property using information in the booking confirmation. No pets and no service animals are allowed at this property.


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Definitions for nystagmus, optokinetic
This page provides all possible meanings and translations of the word nystagmus, optokinetic
U.S. National Library of Medicine
Nystagmus, Optokinetic
Normal nystagmus produced by looking at objects moving across the field of vision.
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Picture: Justin Bieber - Justin Bieber performs live in concert at Pavilhao Atlantico - Lisbon, Portugal - Monday 11th March 2013
Pop star Justin Bieber has blamed his London meltdown on his punishing schedule, insisting gruelling daily workouts, homesickness, and the strain of performing live took a toll on him.
The Baby singer hit headlines around the world on Friday (08Mar13) when he was filmed in a foul-mouthed clash with a paparazzo in the U.K. capital.
The incident came after days of mounting pressure on the teen star, who was criticised for turning up late for his opening gig at London's O2 Arena on 4 March (13) and had a bust-up with bouncers at a nightclub as he celebrated his 19th birthday on 1 March (13).
His 10-day trip to Britain ended in chaos and controversy on Friday when Bieber was caught on camera threatening to "beat the f**k out of" a snapper outside his London hotel, but now the Canadian star has spoken out, blaming his behaviour on a "hard" few days.
He tells German newspaper Bild, "It was a hard week. I was working out every morning and had a huge show every night. When people are pushing their camera in your face all day long and yell mean things at you (it's hard). I'm only human, too. I'm far away from home, I miss my family, my siblings and my friends."


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Skeletal Knight by DiegoGisbertLlorensWatch
©2013-2016 DiegoGisbertLlorens
Card art for Mage Wars.
Fabulous hairstyle!
Love it
Looks like a Necron
I really love the glowing mist in this one and the saturated blue you splashed around. Wonderful design, great color theory, and nice emphasis on the character. You're style is something to admire for sure!
Thanks for the compliment. Classical illustrators like Frazetta played with saturated colors in a similar way (just better!).
Pulling inspiration from classic artists and masters is a wonderful way to practice and learn! I'm happy to hear you had the right kind of inspiration. I can't wait to see what you do in the future!
amo! AMO!!
Amo del verbo amar, o amo de puto amo?
Tremendo ^^ Me recuerda a los de HoMM
¿Los de qué?
Heroes of Might and Magic. Seguramente hallas jugado a uno de la saga. www.heroesofmightandmagic.com/…
Very epic.


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Frisco Independent School District in northeast Texas has chosen Mizuni SIF Integration Tools for its growing technology and data processing needs. The district, which enrolls about 31,000 K-12 students, has experienced annual growth of between 12 percent and 30 percent over the last decade, and its demands for more efficient and reliable data management have subsequently skyrocketed.
Prior to implementing the Mizuni application, one of FISD's common issues was the inefficiency of multi-point redundant data entry. "To keep up with our growth in the past, we allocated up to five full-time employees for data entry during our spring and summer hiring season," said Melissa Fouche, FISD's Chief Technology Officer. "The Mizuni Solution significantly reduces our data entry time, allowing us to deliver more teacher-based services."
In addition to the features of the software itself, FISD cited Mizuni's customer service as integral to their choice. Explained FISD database administrator Jayme Endicott, "We can depend on Mizuni Support to quickly resolve an issue and clearly explain how it came to resolution."
Finally, added Endicott, "Teachers now have access to all of their instructional resources during summer professional development. This allows them to start fully trained and prepared for a successful school year."
About the Author
Scott Aronowitz is a freelance writer based in Las Vegas. He has covered the technology, advertising, and entertainment sectors for seven years. He can be reached here.
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text: San Beda College (SBC or San Beda) or Dalubhasaan ng San Beda in Filipino and Colegio de San Beda in Spanish is a Private Roman Catholic Benedictine college run by the Benedictine monks in the Philippines. It is located in Mendiola, Manila, for college and Taytay, Rizal for Elementary and High School. It was founded in 1901 primarily to "defend the Catholic battlements in the field of education." San Beda, which was known then as El Colegio de San Beda, started as an all-boys grade school.


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Video Industry News Video Company News Technology Industry News Technology Company News Novelty Industry News Novelty Company News Gay Industry News Gay Company News Legal Industry News All Company News
Company News: Pocket Dungeon, A Williams Trading Exclusive, Adds Ms. Ming's Mini Benyi Kit
Published: November 17, 2014
Pocket Dungeon, a complete travel-sized BDSM kit exclusively distributed by Williams Trading Co., has expanded their line to include the Ms....
Profile: Ming (II) (amateur)
Photos: 'Mommy & Me' co-stars Ming Ballard and Keeffe Griffith
Photographer: IndustryByRick/EMMreport.com
Published: February 25, 2011
Photos: Ming Ballard, co-star of 'Mommy & Me'
Photographer: IndustryByRick/EMMreport.com
Published: February 25, 2011
Movies: Ladyboy Cocks
Profile: Ming (I) (Trans)
Profile: Ming Lee
Profile: Langdon Ming
Profile: Ming Lynn
Profile: Troy Adam Ming
Profile: Sexton Ming
Article: AVN Presents the Nominees for the 7th Annual 'O' Awards
Published: November 25, 2015
Now in its seventh year, the "O" Awards honor the best products and collections from leading and cutting-edge manufacturers.
Company News: Williams Trading Releases 2014 Christmas Essentials Digital Catalog
Published: November 18, 2014
Williams Trading has released the 2014 Christmas Essentials Catalog and it's now live on the distributor's website.
Article: Broadcast 'Porn' to the People in China, Go to Jail
Published: September 05, 2014
He got a little more than a day in jail for each of the ten minutes of the banned movie he allowed to be broadcast earlier this week on the...
Company News: pjur Has New Distributor In Singapore
Published: July 15, 2014
pjur has signed a distribution deal with Male-HQ to bring the line of lubricants and personal care products to Singapore.
Article: Spring Into the Season: Report From International Lingerie Show
Published: May 08, 2014
The spring International Lingerie Show was just the place to be to kick off the slimming season, offering plenty of incentives for dropping...
Company News: Williams Trading Co. Releasing Pocket Dungeon To Target BDSM Market
Published: March 31, 2014
Exclusive to Williams Trading Co., the Pocket Dungeon will debut to the industry at the International Lingerie Show, now through Wednesday.
Article: Classic Chinese Porn Novel Gets Epic Translation into English
Published: November 22, 2013
It might just be the Great Chinese Novel, written by an anonymous author 500 years ago. But it's also perhaps the most pornographic novel ever...
Company News: LELO Upgrades Two Favorites: Gigi 2 and Liv 2
Published: August 16, 2013
Upgrades for both include fully waterproof exteriors covered in even softer body-safe silicone, an increase from five to eight total massage...
Company News: LELO Launches Mia 2, An Upgraded Version of Best-Selling USB-Rechargeable Vibe
Published: November 29, 2012
Swedish designer brand LELO has today launched Mia 2, a newly-upgraded version of their iconic lipstick-vibe with USB charging, which holds the...


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Chefuniverse Feb 3, 2012 5:42 PM
in response to lars-bo-rasmussen
My Iphone 4s just went dead during the night as well. I trie3d charging it and everything but still couldnt turn it back on. It was completely useless. So i packed it up back in the box and was ready to head to the apple store to get it set again but decided to check for solutions online. So i googled IPHONE 4S GOING DEAD and got the answers on how to restart. Thanks to your comments it saves me the hassle of going to get this rectified. But apple should really look into this matter and come up with a solution. Pressing down and holding both keys does restarts the phone but it definately drains out the battery..dont know why though..
Thanks for the support guys ..
WhiteMaster Feb 15, 2012 2:23 AM
in response to lars-bo-rasmussen
Mine is just one month old and just did the same.. this is the least one would expect from an expensive gadget like this.. the premium is paid for the quality and this is not acceptable at all..
I did not realize that my phone was down until someone used a land-line to reach me and tell me that there was no response on my mobile phone..
I hope apple sees this as a problem.. and addresses it.
PdiddyDSP Mar 16, 2012 4:52 AM
in response to lars-bo-rasmussen
My Iphone 4s was charged, and fine one minute. Then completly died. plugged in to make SURE batt was charged. Waited a few hours. Then read your post. Reset worked. I have had this phone for 6 months with no problems. Thank you so much. (Some of us can't function without their phone).
phonytony Apr 5, 2012 5:37 AM
in response to lars-bo-rasmussen
Yeah So this is my first Iphone (4S). I have been an avid Droid user for years and always had great luck with them (battery, OS, ect). So I decided a week ago March 25th 2012 to take the plunge and get an iphone family plan with my significant other, assuming "what the heck, everyone says the battery life is the best thing about the phone". From day one this phone has been dog**** battery-wise. Not only is my phone affected, but my girlfriend's same model phone is the same exact way. So let me get to it already:
I consider myself a tech-savy person and thought hey I can figure this out, man have I been wrong, along with 98% of 4S users. So the phone came stocked with iOS 5.0.1 I think. After suffering bad battery life for two days, with realistic/perfect charging to condition the battery, I assumed it was either a bad battery or iOS issue. I realized there was an update due for iOS 5.1 that noted bugs and fixes for battery issues. I proceeded to DL and Install once I had a full battery charge, while being plugged in. I thought to myself, "this is great, finally!" but to no avail; the battery life was still terrible... No Gain or Loss compared to before. Let me elaborate a bit...
*Stock Phone out of box iOS 5.0.1 (03/26/12)
-Day 1 with 100% charge, everything set to default, wifi off when not in use. I unplug from charger at 515am to get ready for work and lay the phone on my desk downstairs and continue to get ready for work. Leave for work and arrive at 7am, phone is at 88-90% (not even touched yet). By 12pm I leave for luch and I am anywhere between 35-40% on battery with on average 3 websites viewed and maybe, just maybe one phone call made. If I made it home at 4pm without my phone dying I don't remember.
-Day 2 (same exact scenario for the most part)
-Day 3 (same scenario) except this time I was proactive after reading about shutting off all the extra background services, apps, siri, ect, but nothing seemed to help at all! Literally if I saved 1-2% I didnt notice.
*Upgraded to iOS 5.1 (03/29/12)
-Day 4. Discovered update that noted bugs and fixes for battery issues and dove in as soon as my phone was at 100% charge. I thought I was finally free form the grips of this...nope. Everything back to default running on 5.1 I had no gain or loss in battery performance. I figured I would again try disabling all the background services listed before, but nothing would help. Sometimes it would drain a lil faster than other, but for the most part I was losing 10-15% an hour at least with the most minimal of use.
-Day 5. I called Apple and their Sr. Advisor acted suprised, as if she hadnt heard of this issue really , and set me up an appointment with the "Genius Bar". Sooo I wait for that appointment hoping for a new update or patch to resolve this issue so I would'nt have to drive 2hrs to the closest apple store.
-Day 6 and 7 resolve nothing other than reading forums and trying to educate myself on the issue.
-Day 8. (04/02/12) I go to the Apple Store. The "Apple Genius" does a diagnostic scan on my phone and determines the battery and hardware seem healthy, but becomes aware of the giant loss in battery as we sat there for 10mins and it dropped over 10%. He was shocked and said "this def is not normal". He proceeded with options, such as "I can wipe the phone clean and give you a new battery or I can just give you a brand new phone". I wanted to rule out hardware entirely so opted for the new handset replacement so I could start from scratch. So we moved forward and I went on my way back home with my 2nd iphone 4S with the original 5.0.1 on it. Charge conditioned it and didnt put any apps at all on it or upgrades. I wanted to see what the culprit was. It still was draining after giving it a lil use (10mins of soft web surfing and a 4min phone call). I seemed to be in the same boat again and dissapointed. I was right to feel that way because my battery issue was there exactly the same as before, except I had an empty phone I had to start all over with again...
-Day 9. (04/03/12) Decided to upgrade new handset to 5.1 hoping for the best, assuming it really just needed that bug fix through the upgrade. Pretty much started my work day at 7am with iOS 5.1 on the new handset with no apps or customizations. Battery life still the same. I could not believe it, so again I disabled all the services listed before to see if it would help along with some other troubleshooting I read about over the weekend... Nothing would help. I could not find the culprit! Battery was still draining at an alarming rate.
-Day 10. (TODAY! 04/04/12) Did my usual 7am-4pm workshift. While at work my battery showed signs of no hope once again, but I decided to get over it for a few minutes and finally use the smartphone portion of my purchase and redownloaded my apps one by one and see how the battery reacted; nothing seemed to help or hinder the battery life.
So here I am at 8pm trying to help the cause by giving the steps I have taken. Sorry if I have left out important details, but I am exhausted over it, so feel free to reply with extensive questioning. My only hope is to shed some light for apple and its iphone users. Too many places I have read that people werent doing enough or were doing too much, which annoyed me because I could relate to every single one of the issues and I know you guys can to. So enough from you guys who say try this, try that, stop using the phone so hard, swap it out at apple, upgrade, restore from itunes, restore from scratch, put it in the oven, put it in the freezer, because NONE of that has worked for me on any level as of yet. Same for my girlfriends phone. None of these steps have helped my battery life and I know there are other in the same boat which is deflating.
Currently my iphone 4S is a white 32gb with iOS 5.1 installed.
I am on Sprint and generally have 4-5 bars of service all the time, including 3G.
My serial number is starts with DQGH12V*****
Model MD246LL
Version 5.1 (9B179)
Let's crush this rediculus issue that has gone on for far too long.
Okay, Important realtime update!
-Day 11. I went to sleep last night at 1030pm with my phone unplugged at 93% and just woke up at 515am to grab it at 90% and currently at 6am it is still at 90%, this is huge for me, but actually realistic...
What did I do different? It it basically in tandem with what a few other dudes were saying on here: the 3G.
I looked on Sprint to see my coverage area (work and home) and it looked good, I am even two houses or so down from excellent service. That said, my phones service bars and data service reflect that considering I get pretty quick upload and download speeds.
So to the difference:
Location Services: ON
System Services: OFF (not that this should be a factor because it never helped before)
Cellular Data Services (3G): OFFFFF!!!!
-Nothing else dissabled and bam.
So with the culprit pointing to the 3G antenna I am going redirect my focus today, but this is the only positive feedback I have been given in the 10 days I have been hammering away at this phone. Apple needs to put us on their payrolls for this?
With all that said, I have not been able to get any momentum the entire time whatsoever with any troubleshooting tactic until now, with just turning off cellular data (3G). I am even running WIFI and tons of apps to push the phone a lil and it isnt budging battery-wise. Like other have said, this def doesnt "fix" the issue , but it is a slight work around that will set your battery life back to the stone age of good batteries.
Go ahead:
Setting>General>Network>Cellular Data (OFF!)
Now this is redic considering your biggest monthly cellphone plan cost is generally your data, but it seems to me it's better temporarily than to have a totally dead phone. I am pretty sure apple has installed some shotty antennas in some of the handsets that is constantly pinging the network hard and it probably has something to do with iOS 5 being 4G ready... This is EPIC FAILURE for this company I think. I think they know it to, but like the original 4S issue it should get solved, but I am sure the flawless iphone 5 will come out then, since they seem preoccupied by it rather than fixing this issue within 6-7 months. I can only hope they knock off $400 dollars at trade in with this phone for the new one at minimum.
Hit me with any other questions.
Another update!!!!
Thanks, I only want to get to the bottom of this like everyone else...
Another side note. I decided to turn on cellular data (3G) about 5mins ago at work, since I don't have wifi, to see how'd she hold up. Keep in mind I was at 89% at 7am when I arrived at work. I am now at 81%. I dropped 7% in 5mins with cellular data turned back on. This is def the main issue by far.
Any thoughts?


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Skip to content, or skip to search.
Skip to content, or skip to search.
Home > Restaurants >
31-29 Ditmars Blvd.,
Queens, NY 11105
Mon-Thu, noon-11pm; Fri, noon-midnight; Sat, 11am-midnight; Sun, 11am-10pm
N, Q at Astoria-Ditmars Blvd.
American Express, Discover, MasterCard, Visa
Accepted/Not Necessary
Michael Psilakis's newest spot is a modern vision of the Greek tavern: floor-to-ceiling glass doors right off the Astoria-Ditmars subway stop invite a happy-hour crowd; plus, there's a selection of whole animals that can be ordered for roasting five days in advance. If you don't have enough dining companions to help you finish an entire spring lamb or kid goat, the remainder of the menu provides an extensive introduction to Greek food. The variety of meze make it easy to build a tapas-style meal that pairs well with the exhaustive wine list. Start with the trio of dips: eggplant, chickpea, and yogurt, served with warm, fluffy pita. The crispy calamari is fried, but not batter-heavy, and served with tzaziki for dipping. There's a variety of fish (such as branzino, swordfish, prawns) from the Simply Grilled portion of the menu, and you can also choose from chicken, pork, beef, and vegetarian souvlaki sandwiches or entrées like spicy lamb sausage and cheese dumplings and Greek paellaorzo and tender sausage is steeped in market-fresh shellfish, served with a spicy tomato sauce. For dessert, try the apple baklavayou'll find new love for apple pie once you've had it re-conceptualized as layers of pastry served with Amaretto ice cream.
Recommended Dishes
Fried calamari, $11.95; combination of yogurt, chickpea, and eggplant dips, $13.95; Greek paella, $24.95


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A new road will mean new business opportunities in Marquette Township.
Crews were hard at work finishing a new road that will connect Commerce Drive to Venture Drive in a new development in the township.
The road is called Cornerstone Road, named after Cornerstone Development, the company that is developing the area.
The quarter mile long road will open 10 acres of land that will be able to house seven new development opportunities with two businesses already interested.
"We're trying to make a business campus concept where businesses can grow off one another and have some synergy to create an economic environment that helps all of their businesses," said Cornerstone Development Manager Jim Clark.
Cornerstone Road will have complete underground utilities along with sewer and water mains. The project was started in September and is expected to be completed in the coming weeks.


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G-Dragon Cookie by Yumek0Watch
©2009-2016 Yumek0
This year I decided to do all the members of Big Bang! I really loved their Lollipop video and so I was inspired by the bright colors to make these cookies. I made them two days ago but I'm finally eating them today XD they are yummy!
View the Lollipop MV here [link]
View the Lollipop MV here [link]
My absolute favorite! You captured the Big Bang fashionista as a cookie! You did an amazing job on all of them, but GD is by far the best [in my opinion]!! All the accessories, the hair, and even his expression!! AWESOME job!!
OMO!!! this is soooo cute!! I want them! >w<


text:
November 25, 2013
Matt Weaver
Kevin Wilson and his staff are trying to land a number of prospects from the state of Florida in the 2014 recruiting class, and one player from the Sunshine State they have targeted is Matthew Boateng. The 6-foot, 180-pound cornerback from Bradenton (FL) IMG Academy spoke to Peegs.com about his recruitment and about his upcoming visit to IU next month. ...More... To continue reading this article you must be a member. Sign Up Now!
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text:
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Floyd Mayweather: Money 'absolutely' means more than a perfect record
Joe Camporeale-USA TODAY Sports Floyd Mayweather is about to make around $200 million by fighting Manny Pacquiao this Saturday at the MGM Grand in Las Vegas. Mayweather, who is 47-0-0, says the $200 million means more to him than keeping his perfect record. "Absolutely," he said Tuesday to reporters, via Boxing Junkie. "At the end of the day, my daughter can't eat a zero...
Via Sports-Glory
April 29, 2015 | Discuss
Full fight videos: Martinez vs. Chavez Jr., Cotto vs. Margarito II
In advance of the Miguel Cotto vs. Sergio Martinez world middleweight championship match, HBO Boxing has released the full fight videos of some of their recent encounters. This includes Sergio Martinez vs. Julio Cesar Chavez Jr., and Miguel Cotto vs. Antonio Margarito II. You can watch both of those full fights right here. In Martinez vs. Chavez, the champ, Maravilla, dominated...
Via Pro Boxing Fans
June 04, 2014 | Discuss
Martinez: "My loss to Margarito … best thing that happened"
MIAMI, FL - Although he struggles his label as the 'B' side in the upcoming bout against Miguel Cotto, Sergio Martinez has little difficulty in candidly sharing some of his career lows. In HBO's most recent blog post, Martinez is asked about his loss against Antonio Margarito and how he foresaw his career in the aftermath. ***** Martinez – After your loss to Margarito...
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May 28, 2014 | Discuss
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Fox Filmed Ent. reached an industry-high $3,559,521,971 in worldwide box office for 2006. This is the biggest worldwide box office gross for any slate of pictures in the history of the movie business, according to the studio.
The milestone was a combined result of strong contributions from all of Fox's existing production divisions, which delivered a diverse slate of pictures from tentpole films such as the animated ICE AGE: THE MELTDOWN and X-MEN: THE LAST STAND.
Among the milestones in this historic achievement, the studio surpassed $2 billion in international receipts for the second time.
The studio began its banner year with Twentieth Century Fox Animation/Blue Sky's ICE AGE: THE MELTDOWN reaching more than $644 million in worldwide ticket sales -- topping all other animated features released in 2006.
X-MEN: THE LAST STAND, the final chapter in the studio's phenomenally successful X-MEN trilogy, attained a worldwide box office of $456 million.
FFE finished the year with two vfx-laden films: ERAGON, which has grossed more than $170 million worldwide so far and NIGHT AT THE MUSEUM, which has grossed more than $127 million in domestic box office. The Ben Stiller comedy has opened in only a few international territories, but has already amassed an impressive $60 million in these early engagements.
Fox Filmed Ent. produces, acquires and distributes motion pictures throughout the world. These motion pictures are produced or acquired by the following units of FFE: Twentieth Century Fox, Fox 2000 Pictures, Fox Searchlight Pictures, Fox Atomic and Twentieth Century Fox Animation.


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Rosita's Place
Nearly every 'hood in the Valley has its own "Best Neighborhood Mexican" restaurant, sometimes more than one. The category exists not for those gourmet, highfalutin Mexican places -- the same four places you always see listed in rags around town, and deservedly so, for exceptional, haute Mexican cuisine. We love those spots, but sometimes you just want a good enchilada, taco, or plate of beans, without having to deal with a lot of B.S., and that's when we cruise over to a spot like Rosita's Place on McDowell Road, just east of the 51, where the albóndigas melt in your mouth and the frijoles are as appetizing as the flan. Some of the best tacos in the Valley vie for your tongue's attention with enchiladas that'll forever make you turn your nose up at the gringo versions sold elsewhere. The environs are authentic as well: Brown, glazed Mexican pottery hangs from orange roof beams, vintage black-and-white pics of Mexican soldiers hang from the walls, and a gurgling, stone-lipped pond/fountain filled with goldfish sits before a makeshift shrine to the Virgin of Guadalupe. Rosita's is a neighborhood Mexican eatery that inspires neighborhood pride. And if you live or work nearby, you're fortunate indeed.
Location Details
More La Vida Awards
BEST PLACE TO FIND MEXICAN FOLK ART ONCE A YEARFriends of Mexican Art (FOMA) Hacienda Tour and Mercado
BEST MEXICAN FOLK ART STORE IN CYBERSPACEfunkychickeneggranch
BEST PLACE TO FIND A QUINCEAÑERA DRESSJoyful Events (a.k.a. Wedding Depot)
BEST PLACE TO FEEL LIKE YOU'RE IN A MERCADO IN MEXICODos Hermanos Centro Comercial


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Changes The Redskins Need To Make In 2014
I'm beginning to feel nauseated from discussing the Washington Redskins shortcomings and deficiencies every week. Due to their horrible season, poor play and many problems, they have given me mostly negative material to work with. So, to create something positive for next season that won't make me feel sick to talk about, here are some suggestions for what the Redskins need to work on to have a more successful 2014.
1. Establish The Run Game
While the Redskins ranked fifth in the NFL this season with 135.2 yards per game and 2,164 total yards, they didn't properly establish their run game. Emphasis on the word establish. They may have racked up a massive amount of rushing yards in 2013, but they never focused on the strongest part of their offense.
The strongest cog in their rushing attack is second-year RB Alfred Morris. Morris rushed for 1,613 yards and 13 touchdowns in his rookie season but only 1,275 yards and seven touchdowns in his sophomore season. This can attributed to his decrease in carries as his average of yards per rush barely changed from 4.8 in 2012 to 4.6 in 2013 — Morris wasn't struggling to run the ball. Morris carried the ball 335 times last season as opposed to 276 times this season. The Redskins neglected to stay with what worked for them last year that also helped them win a division title: handing the ball off to a one-time Pro Bowler who rushed for more than 1,600 yards.
Morris did receive 17.2 carries per game this season, but the offense itself was heavily imbalanced. In 2013, the Redskins averaged 38 passing plays per game but only 28 rushing plays per game. This baffles me as they have weapons on the ground including Morris, his backups Roy Helu and Evan Royster, FB Darrel Young and QB Robert Griffin III.
If the Redskins want to be successful they need to take some notes on the San Francisco 49ers and Seattle Seahawks' playbooks. Both teams have had success over the past few seasons because they built their offenses around the run game. They got RBs Frank Gore and Marshawn Lynch going, and once they were effective, defenses would play call to stop them. That would open up the passing game, or even run plays for their QBs Colin Kaepernick and Russell Wilson.
2. Play Better Defense / Hire New Defensive Coordinator
We all know Washington played atrociously on the defensive side of the ball this year — it simply was a mess. The Redskins gave up 354.1 yards per game and allowed 29.9 points per game — second most in the league. Three times this year, the 'Skins allowed more than 40 points and seven times they allowed more than 30. Defense was their biggest problem even after you take into account everything that went on with the offense, such as RGIII being benched.
Washington's poor defensive play is another aspect of this season that really didn't make sense to me. The previous season their defense had rallied together for their last seven games to pull out seven wins. It seemed like they were trending upward. And add to that the personnel they have on their defense: OLB Ryan Kerrigan, OLB Brian Orakpo, MLB Perry Riley, MLB London Fletcher (now retired), CB Josh Wilson, CB DeAngelo Hall, S Brandon Meriweather and DT Barry Cofield. There is/was a lot of young talent on the Redskins' defense that are already battle-tested, along with some experienced veterans who are still playing quality football. So this inability to play well together given previous success and a great cast of starters makes me not question the players but the coaching. Specifically, the defensive coordinator.
It is time that defensive coordinator Jim Haslett is relieved of his duties. The Redskins defense couldn't stop anyone this year even with their high-quality personnel. Haslett clearly didn't have the right scheme in place or couldn't rally his players to play solid football as one cohesive unit. Sorry, Jim, but your time should be up in Washington.
3. Get A Second Wide Receiver Option
Everyone should have seen this one coming. While RGIII may have not had the best season, he wasn't provided much help in terms of wide receivers. This season, the quarterbacks only real target was WR Pierre Garçon. Garçon had a monster year, catching 113 passes for 1,346 yards and five touchdowns (he would have been a Pro Bowler if it weren't for the other great receivers this season).
Next on the list? TE Jordan Reed with 45 catches, 499 yards and three touchdowns. And Reed was a rookie tight end who wasn't expected to contribute this season. After him is veteran WR Santana Moss with 42 catches, 452 yards and two touchdowns.
The hard truth is that the drop-off from the No. 1 to No. 2 receivers for the Redskins this season — and just wide receivers, not including tight ends — was 113 catches to 42. That's a difference of 71 catches between Washington's two most productive receivers (if you can call Moss's season productive). This blatantly shows that the Redskins, and RGIII, need another receiver.
Washington doesn't have a first-round pick this year, so they can't expect to get a top three wide receiver in the draft without trading up. If they don't take a receiver in the second round, like I think they should, then I highly suggest they go after a free agent wide out. And this isn't a bad year for free agent wide receivers. The Redskins will be able to offer contracts to Eric Decker, Jeremy Maclin, Hakeem Nicks, Julian Edelman, James Jones and many more.
4. Improve Offensive Line Play
A strong run game in 2013 would, under normal circumstances, point to a competent offensive line. But another stat besides rushing yards says otherwise. And that stat is quarterback hits. In 2013, the Redskins allowed their quarterback to be hit 95 times, 10th most in the league.
And the poor line play was evident when watching their games this season. It seemed as if on every play RGIII or Kirk Cousins have two seconds at most to drop back and get rid of the ball. A good offensive line will give their quarterback at least four to five seconds to make a decision. The Redskins, as the quarterback hits stat says, allowed pass rushers to get to their quarterback way too often.
If the Redskins want their pass attack and third year quarterback to flourish next season, they need to step it up. They need to give RGIII more protection and time. This will not only allow him to have more time to pass and play better, but will keep him safe and possibly prevent future injuries.
And in the run game, offensive line play is equally crucial. With the talents of Morris and RGIII running the ball, it will mainly be up to the big guys up front to create holes and make key blocks.
5. Tweak The Offense's Play Calling
Whoever is the offensive coordinator next year will need to make some adjustments when it comes to play calling. While I do like the pistol offense and the plays that were installed for RGIII, they may need to be toned down or modified.
When I see Washington's plays unfold each down, many appear to put RGIII in danger of receiving a big hit. He is already struggling with when to know to slide, so calling plays that put him in positions to make that decision increases his probability of getting hurt. The Redskins need to decrease those plays significantly and add in designed runs that will allow him to get into open space for big gains and stay away from defenders.
The read-option is another big part of the Redskins' offense that needs to be adjusted. The read-option is perfect for RGIII, but it is also another play that puts him in harm's way. The Redskins need to look at what the Philadelphia Eagles did with the read-option this year. When QB Nick Foles came into the starting quarterback role, head coach Chip Kelly knew he wouldn't be as dangerous a runner as QB Michael Vick. So, on most read-options, or plays designed to look like read-options, Foles handed the ball off. And on the ones he didn't hand off, they ended being play-action fakes that temporarily froze defenses and allowed him to throw the ball to an open receiver. If Washington had read-options, or pseudo read-options like this, then it would keep RGIII safe and make their offense more dynamic. He has the arm to make big throws and is accurate enough to win games with just his arm alone.
The Redskins in 2014 need to be smarter with their play calling. To maximize RGIII and all of his talents, they need to keep him safe, allow him to use his arm to propel the Redskins to victory and use his Olympic speed when defenses least (emphasis on least) expect it.


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Publications (12)40.85 Total impact
Article: Carnitine deficiency is associated with late-onset hypogonadism and depression in uremic men with hemodialysis[Show abstract] [Hide abstract]
ABSTRACT: Abstract Late-onset hypogonadism (LOH) and depression contribute to cardiovascular disease (CVD) in male hemodialysis (HD) patients. Carnitine deficiency is frequently observed in HD patients, playing a role in CVD. We examined whether carnitine deficiency was independently associated with LOH and depression in these patients. Twenty-six male HD patients underwent determinations of serum levels of free carnitine and testosterone. Status of LOH and depression were evaluated by questionnaires using aging male symptoms' (AMS) scale and self-rating depression scale (SDS), respectively. Free carnitine and testosterone levels in male HD patients were significantly lower than those in age-matched healthy male subjects. Linear regression analysis showed that AMS scale was positively associated with SDS. Univariate regression analysis revealed that total carnitine (inversely), free carnitine (inversely) and HD duration were correlated with AMS scale. Multiple stepwise regression analysis revealed that free carnitine was an independent determinant of AMS scale. Furthermore, free carnitine was also independently correlated with SDS in male HD patients. This study demonstrated that decreased free carnitine levels were independently associated with AMS scale and SDS in male HD patients. The observations suggest that decreased free carnitine levels could be a marker and therapeutic target of LOH and depression in uremic men with HD.
Article: Asymmetric dimethylarginine accumulates in the kidney during ischemia/reperfusion injury. Kidney Int[Show abstract] [Hide abstract]
ABSTRACT: Ischemia/reperfusion injury is the leading cause of acute tubular necrosis. Nitric oxide has a protective role against ischemia/reperfusion injury; however, the role of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, in ischemia/reperfusion injury remains unclear. ADMA is produced by protein arginine methyltransferase (PRMT) and is mainly degraded by dimethylarginine dimethylaminohydrolase (DDAH). Here we examined the kinetics of ADMA and PRMT and DDAH expression in the kidneys of ischemia/reperfusion-injured mice. After the injury, DDAH-1 levels were decreased and renal and plasma ADMA values were increased in association with renal dysfunction. Renal ADMA was correlated with 8-hydroxy-2'-deoxyguanosine, a marker of oxidative stress. An antioxidant, N-acetylcysteine, or a proteasomal inhibitor, MG-132, restored these alterations. Infusion of subpressor dose of ADMA exacerbated renal dysfunction, capillary loss, and tubular necrosis in the kidneys of ischemia/reperfusion-injured wild mice, while damage was attenuated in DDAH transgenic mice. Thus, ischemia/reperfusion injury-induced oxidative stress may reduce DDAH expression and cause ADMA accumulation, which may contribute to capillary loss and tubular necrosis in the kidney.Kidney International advance online publication, 9 October 2013; doi:10.1038/ki.2013.398.
Article: Potential Inhibitory Effects of (L)-Carnitine Supplementation on Tissue Advanced Glycation End Products in Patients with Hemodialysis[Show abstract] [Hide abstract]
ABSTRACT: Background and aims: Advanced glycation end products (AGEs) contribute to cardiovascular disease in patients with hemodialysis (HD). We have recently found that carnitine levels are inversely associated with skin AGE levels in HD patients. We examined whether L-carnitine supplementation reduced skin AGE levels in HD patients with carnitine deficiency. Methods: This was a single-center study. One hundred and two HD patients (total carnitine levels <50 μmol/L) were enrolled and randomized to either oral administration of L-carnitine (900 mg/day) (n=51) or control (n=51). After 6 months, metabolic and inflammatory variables, including serum levels of carnitine, were measured. Skin AGE levels were determined by evaluating skin auto-fluorescence with an AGE-reader. Results: There were no significant differences of clinical variables at baseline between the control and L-carnitine therapy group. Thirty-two patients did not complete the assessment or treatment of the study. Oral L-carnitine supplementation for 6 months significantly increased low-density lipoprotein cholesterol (LDL-C), triglycerides, total, free, and acyl carnitine levels, while it decreased alanine transaminase, acyl/free carnitine ratio, β₂-microglobulin, and skin AGE values. Change in total carnitine values from baseline (Δtotal carnitine) and Δfree carnitine were inversely associated with Δskin AGE levels in L-carnitine-treated patients (p=0.036 and p=0.016, respectively). In multiple regression analysis, Δfree carnitine was a sole independent determinant of Δskin AGEs (R²=0.178). Conclusions: The present study demonstrated that oral L-carnitine supplementation significantly decreased skin AGE levels in HD patients with carnitine deficiency. These observations suggest that supplementation of L-carnitine might be a novel therapeutic strategy for preventing the accumulation of tissue AGEs in carnitine-deficient patients with HD.
Article: Involvement of advanced glycation end product-induced asymmetric dimethylarginine generation in endothelial dysfunction[Show abstract] [Hide abstract]
ABSTRACT: Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, plays a role in endothelial dysfunction, an initial step of atherosclerosis. Advanced glycation end products (AGEs) also contribute to accelerated atherosclerosis. However, a pathophysiological crosstalk between ADMA and AGEs remains unclear. In this study, we investigated the relationship between ADMA and AGE level in patients with end-stage renal disease (ESRD) due to diabetic nephropathy. We also examined whether and how AGEs increased ADMA generation by cultured endothelial cells (ECs). Plasma ADMA levels were positively associated with serum AGE level and were inversely correlated with endothelial function determined by flow-mediated vasodilatation. AGEs dose dependently increased reactive oxygen species (ROS) generation in ECs, which was blocked by antisense DNA raised against receptor for AGEs (RAGE). Furthermore, AGEs decreased messenger RNA (mRNA) level of dimethylarginine dimethylaminohydrolase (DDAH)-II, an enzyme for ADMA degradation, reduced its total enzymatic activity and resultantly increased ADMA, all of which were completely blocked by an antioxidant, N-acetylcysteine. These results suggest that the AGE-RAGE-mediated ROS generation could be involved in endothelial dysfunction in diabetic ESRD patients partly by increasing the ADMA generation via suppression of DDAH activity in ECs.
Article: DNA Aptamer Raised Against AGEs Blocks the Progression of Experimental Diabetic Nephropathy[Show abstract] [Hide abstract]
ABSTRACT: Advanced glycation end products (AGEs) and their receptor (RAGE) play a role in diabetic nephropathy. We screened DNA aptamer directed against AGEs (AGEs-aptamer) in vitro, and examined its effects on renal injury in KKAy/Ta mice, an animal model of type 2 diabetes. Eight week-old male KKAy/Ta or C57BL/6J mice received continuous intraperitoneal infusion of AGEs- or control-aptamer for 8 weeks. AGEs-aptamer was detected and its level was increased in the kidney for at least 7 days. The elimination half-lives of AGEs-aptamer in the kidney were about 7 days. Compared with C57BL/6J mice, glomerular AGEs levels were significantly increased in KKAy/Ta mice, which were blocked by AGEs-aptamer. Urinary albumin and 8-hydroxy-2'-deoxy-guanosine levels were increased, and glomerular hypertrophy and enhanced extracellular matrix accumulation were observed in KKAy/Ta mice, all of which were prevented by AGEs-aptamer. Moreover, AGEs-aptamer significantly reduced gene expression of RAGE, monocyte chemoattractant protein-1, connective tissue growth factor or type-IV collagen both in the kidney of KKAy/Ta mice and in AGEs-exposed human cultured mesangial cells. Our present data suggest that continuous administration of AGEs-aptamer could protect against experimental diabetic nephropathy by blocking the AGEs-RAGE axis and may be a feasible and promising therapeutic strategy for the treatment of diabetic nephropathy.
Article: Effects of Switching From Calcium Carbonate to Lanthanum Carbonate on Bone Mineral Metabolism in Hemodialysis Patients[Show abstract] [Hide abstract]
ABSTRACT: Phosphate binders are useful for the treatment of hyperphosphatemia in hemodialysis (HD) patients. This study was performed to examine the effects of switching from calcium carbonate (CC) to lanthanum carbonate (LC) on bone mineral metabolism and inflammatory markers in HD patients. We conducted 29 stable HD patients receiving CC, which was replaced by LC and followed-up for 12 weeks. Patients underwent determinants of blood chemistries such as serum calcium (Ca), phosphorus, parathyroid hormone (PTH) and vitamin D status, and interleukin-6 (IL-6) mRNA levels in whole blood cells were evaluated by real-time PCR just before and after the treatment with LC. Corrected levels were significantly reduced, but serum phosphorus levels (P levels) were unchanged after LC treatment. Switching to LC increased whole-PTH, osteocalcin, 1,25(OH)2D3 levels and 1,25(OH)2D3/25(OH)D3 ratio. 1,25(OH)2D3/25(OH)D3 ratio was negatively correlated with HD duration. Furthermore, whole blood cell IL-6 mRNA levels were significantly reduced by LC treatment. We provided that the switching from CC to LC improved Ca overload and ameliorated vitamin D and inflammatory status in HD patients. These observations suggest that LC may play a protective role for the progression of atherosclerosis and vascular calcification in these patients.
Article: Evidence for a Positive Association Between Serum Carnitine and Free Testosterone Levels in Uremic Men with Hemodialysis[Show abstract] [Hide abstract]
ABSTRACT: Background and aims: Low free testosterone levels are associated with sexual dysfunction and an increased risk of cardiovascular disease in male hemodialysis patients. Carnitine deficiency is frequently observed in hemodialysis patients as well. However, the relationship between carnitine and testosterone levels remains unknown. In this study, we examined whether carnitine deficiency was independently associated with low free testosterone levels in male hemodialysis patients. Methods: Nineteen male hemodialysis patients underwent determinations of blood chemistries, including serum levels of free testosterone, carnitine, and pentosidine, one of the well-characterized advanced glycation end products. Results: Mean free testosterone levels in hemodialysis patients were significantly lower than those in healthy controls (4.67±2.69 vs. 9.50±3.67 pg/mL, p<0.001). Univariate analysis revealed that carnitine (p=0.023), pentosidine (inversely, p=0.027), blood glucose (inversely, p=0.032), creatinine (p=0.026) levels, and statin use (inversely, p=0.034) were correlated with free testosterone values. Multiple stepwise regression analysis revealed that carnitine (p=0.001) and statin use (inversely, p=0.002) were the independent determinants of age-adjusted free testosterone levels in hemodialysis patients (r² =0.612). Conclusions: The present study gives the first evidence that decreased carnitine levels were independently associated with low free testosterone values in male hemodialysis patients. Our study suggests that decreased carnitine levels may be a novel therapeutic target for uremic men with hemodialysis.
Article: Experimental diabetic nephropathy is accelerated in matrix metalloproteinase-2 knockout mice[Show abstract] [Hide abstract]
ABSTRACT: Background Matrix metalloproteinase-2 (MMP-2) is responsible for the degradation of various types of extracellular matrix (ECM) proteins such as type IV collagen. Decreased MMP-2 expression and activity has been generally thought to contribute to increased accumulation of ECM at the advanced stage of diabetic nephropathy. However, the kinetics and role of MMP-2 in the early phase of diabetic nephropathy remain unclear. To address this issue, we examined whether streptozotocin (STZ)-induced early diabetic nephropathy was accelerated in MMP-2 knockout (KO) mice.Methods Diabetes was induced by the injection of STZ in 6-week-old control and MMP-2 KO mice. Animals were killed after 16 weeks of diabetes of after observation alone.ResultsCompared with non-diabetic control mice, renal MMP-2 expression and activity were increased in 16-week old diabetic mice. Serum levels of blood urea nitrogen and creatinine and urinary excretion levels of albumin and N-acetyl-β-d-glucosaminidase were significantly elevated in diabetic MMP-2 KO mice when compared with wild-type diabetic littermates. Further, accumulation of ECM in the glomeruli and atrophy and fibrosis in the tubulointerstitium were exacerbated, and renal α-smooth muscle actin expression was enhanced in diabetic MMP-2 KO mice.Conclusions Our present study suggests that renal expression and activity of MMP-2 are increased as a compensatory mechanism in the early phase of diabetic nephropathy. Since MMP-2 could play a protective role against the progression of diabetic nephropathy, further enhancement of MMP-2 expression and/or activity in the kidney may be a therapeutic target for the treatment of early diabetic nephropathy.
Article: Decreased serum carnitine is independently correlated with increased tissue accumulation levels of advanced glycation end products in hemodialysis patients.[Show abstract] [Hide abstract]
ABSTRACT: Aim: There is accumulating evidence that advanced glycation end products (AGE) play a role in cardiovascular disease (CVD) in patients with haemodialysis (HD). Carnitine deficiency is frequently observed in HD patients, which may also contribute to CVD. In this study, we examined whether carnitine deficiency was independently associated with increased tissue accumulation levels of AGE in HD patients. Methods: One hundred and twenty-nine HD patients underwent determinations of blood chemistries including serum level of carnitine. Tissue AGE levels were evaluated by measuring skin autofluorescence with an AGE-reader. Results: Serum carnitine levels were significantly lower, while skin AGE levels were significantly higher in HD patients compared with healthy controls (P < 0.001). In univariate analysis, β2-microglobulin (β2-MG) and carnitine (inversely) were correlated with skin AGE levels. Multiple stepwise regression analysis revealed that carnitine levels were one of the independent determinants of skin AGE levels (P = 0.024). When β2-MG-adjusted skin AGE levels were stratified by serum carnitine levels, a statistical significance and dose-response relationship were observed (P = 0.043). Furthermore, skin AGE levels were one of the independent determinants of serum carnitine levels as well (P = 0.012). Conclusion: The present study demonstrated that decreased carnitine levels were independently associated with increased skin AGE levels in HD patients. Since carnitine is reported to inhibit the formation of AGE in vitro, our study suggests that supplementation of carnitine may be a therapeutic target for preventing the accumulation of tissue AGE and subsequently reducing the risk of CVD in HD patients.
Article: Proteinuria elevates asymmetric dimethylarginine levels via protein arginine methyltransferase-1 overexpression in a rat model of nephrotic syndrome[Show abstract] [Hide abstract]
ABSTRACT: Proteinuria is an independent risk factor for cardiovascular disease (CVD) in patients with chronic kidney disease (CKD). Asymmetric dimethylarginine (ADMA) is a mediator of endothelial dysfunction and is associated with proteinuria in CKD patients. Thus, ADMA can partially account for the increased risk of CVD in CKD patients presenting proteinuria. However, a causal relationship between proteinuria and ADMA remains to be demonstrated. We first investigated whether and how proteinuria might increase ADMA levels in adriamycin (ADR)-treated rats. Next, we examined the effects of human serum albumin (HSA) on ADMA production by human renal proximal tubular epithelial cells (RPTECs) cultured in vitro. Proteinuria was associated with ADMA levels in ADR treated rats. Although ADR treatment did not affect the expression levels of the dimethylarginine dimethylaminohydrolase (DDAH)-1 or -2 enzymes that degrade ADMA, it significantly increased the expression levels of protein arginine methyltransferase-1 (PRMT-1) that facilitates the production of ADMA. HSA increased the generation of reactive oxygen species in RPTECs, which was blocked by the anti-oxidant N-acetylcysteine (NAC) or an inhibitor of NADPH oxidase. Furthermore, HSA increased ADMA generation by RPTECs in a dose- and time-dependent manner and induced gene expression of PRMT-1 but not DDAHs, which were also suppressed by NAC. Our data suggest that proteinuria might enhance ADMA generation in tubular cells, at least in part via the overexpression of PRMT-1 triggered by oxidative stress. Our findings thereby propose a mechanistic link between proteinuria and ADMA levels in CKD patients.
Article: Association of Asymmetric Dimethylarginine with Severity of Kidney Injury and Decline in Kidney Function in IgA Nephropathy[Show abstract] [Hide abstract]
ABSTRACT: Asymmetric dimethylarginine (ADMA) plays important roles in the pathogenesis of chronic kidney disease (CKD). We have recently found that ADMA is involved in glomerular sclerosis and tubulointerstitial fibrosis in an animal model of CKD. However, relationship between plasma ADMA levels and severity of renal damage in CKD patients remains unknown. Relatively young 109 biopsy-proven IgA nephropathy (IgAN) patients (age: 32.7 ± 13.2; estimated glomerular filtration rate, eGFR: 86.5 ± 28.8 ml/min/1.73 m²) were enrolled. We retrospectively investigated whether plasma levels of ADMA were associated with severity of the renal tissue damage and could be a predictor of the disease progression in our subjects. ADMA levels were higher in IgAN patients than age-, sex- and mean eGFR-matched healthy volunteers (0.53 ± 0.14 vs. 0.43 ± 0.08 μM, p < 0.01). ADMA levels were associated with the severity of glomerular and tubulointerstitial injury. Multiple stepwise regression analysis revealed that ADMA, but not proteinuria was an independent determinant for the disease progression assessed by annual reduction rates of eGFR. In univariate analyses, ADMA levels were correlated with proteinuria, total cholesterol, triglycerides, and uric acid. Proteinuria was a sole independent correlate of ADMA in multiple stepwise regression analysis. The present study demonstrated that ADMA was correlated with the severity of the renal tissue damage and could be a predictor of disease progression in IgAN patients.
Article: [Case of acute kidney injury related to intravenous zoledronic acid in a patient with multiple myeloma].[Show abstract] [Hide abstract]
ABSTRACT: We report the first case of acute kidney injury related to intravenous zoledronic acid (ZA)in a patient with multiple myeloma in Japan. A 37-year-old male was diagnosed as having multiple myeloma (MM) of the Bence Jones lambda type. He showed a good response to two courses of vincristine, adriamycin and dexamethasone (VAD) therapy, and remarkable reduction was seen in plasma cells in bone marrow from 38.4% to 6.8% and 24-hour urine protein from 18.5 g/dL to 2.8 g/dL. At that time, serum Cr(s-Cr) of 0.7 mg/dL and calcium of 9.3 mg/dL were in the normal range. ZA was administered intravenously at the dose of 4 mg for the first time. Subsequently, he developed a fever of up to 39.4 degrees C and used NSAIDs and cefepime. Four days later, s-Cr increasd rapidly to 7.3 mg/ dL and he received hemodialysis (HD) therapy. Four weeks later, renal biopsy was performed and demonstrated cast nephropathy (CN) and acute tubular necrosis. Seven months later, renal function had improved. ZA may be an identifiable precipitating factor of CN. We recommend that ZA should be used with caution, especially hypovolemia and NSAIDs, in patients with MM and renal insufficiency.
Top Journals
Kurume University
Куруме, Fukuoka, Japan
- • Division of Nephrology
- • School of Medicine


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Thursday, May 08, 2008
1 comments
Hi everyone! I feel like this update was necessary because I've been neglecting SP for over a week. I'm still alive and well but I've had "a lot on my plate" recently. I'm moving out on my own for the first time on Friday and the past month has ... Read more
Friday, April 25, 2008
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Today I was featured in the sparkpages spotlight and I'm blown away from all the responses & comments I've been getting. Thank you all for your supportive comments to me. They couldn't have come at a better time. I've been really stressed out fo... Read more
Thursday, April 03, 2008
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My dad is not in the best of health these last few years. He's smoked his entire life and has been morbidly obese since before I can remember. Well he ended up in the hospital the other day due to his chronic lung infection. But during this sta... Read more
Sunday, March 23, 2008
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So I've always been the quiet/moderately shy type person. That's fine I've always got along well and no one ever really questioned it. No one has ever pushed me or tried to coax me to be anything else. But I've really tried to become a little m... Read more
Sunday, March 16, 2008
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I figured now is a good time to update as any. I've been really busy working and dog sitting over the past couple a weeks so I missed my weigh in this week. I believe I have lost a little bit though, my clothes seem to be getting a touch bigger ... Read more
Wednesday, February 27, 2008
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I've hit a bit of a plateau this month. I've been hovering around 166-168 lbs for the last few weeks. I think this plateau has been a bit oif toirture because I'm so close to my next mini goal weight of 165. Through this whole weight loss journe... Read more
Saturday, February 23, 2008
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This week I've been making progress with my objectives:
I went to the grocer and chose foods that were good for me. I've been logging all of my food, I've done my cardio routine 3x this week, and I managed to strength train today.
I'm re... Read more
Monday, February 18, 2008
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So I've really been off track with everything lately. I haven't been tracking anything as faithfully as should. I need to put more time into getting all my food logged because that's what works for me. I also haven't done much exercise lately. S... Read more
Wednesday, February 13, 2008
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So I weighed in today 2.5 lbs more than last week and I'm actually not upset about it. I've been really sick the past couple of weeks with bronchitis and last week I lost 6 lbs because I wasn't really eating at all. So this week's gains are abso... Read more
Wednesday, January 23, 2008
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So today has been a mixed bag of happiness. I went out to find some work out clothes but came home with as new wardrobe of street clothes. Which I'm okay with. The search for work out clothes will continue in the next day or two. Anyway none of... Read more
Monday, January 14, 2008
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I'm so thankful for all my family and friends that support me.... Read more
Thursday, January 03, 2008
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First things first ...My pedometer is alright which I'm so thankful for. I now double check my pockets whenever I throw laundry in the washer. In the weight loss department I've done wonderfully over the holidays which is great but I'm not overw... Read more
Saturday, December 22, 2007
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Please pray for the recovery of my pedometer. Tonight I opened the washing machine and sitting on top was my soaked step counter. I'm hoping that it just needs to dry out a bit, but a part of me is thinking that it is dead forever. I just cann... Read more
Monday, December 10, 2007
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I haven't had a ton of it lately, or rather should I say I haven't had much time to myself lately. Over the course of this month I've been kind of going through the motions of being a responsible adult with my numerous errands and well paying th... Read more
Wednesday, November 14, 2007
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I weighed in at 196 lbs today. That is a total 2 lb loss for the week. Yippee! Now I'm just 6 lbs away from my next mini goal. Oh and I'm only 3 lbs away from a total weight loss of 60 lbs.... Read more