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Are you Patricia Ruiz Noppinger?Claim your profile
Publications (15)110.26 Total impact
Article: Sex- and age-dependent effects of Gpr30 genetic deletion on the metabolic and cardiovascular profiles of diet-induced obese mice[Show abstract] [Hide abstract]
ABSTRACT: The G protein-coupled receptor 30 (GPR30) has been claimed as an estrogen receptor. However, the literature reports controversial findings and the physiological function of GPR30 is not fully understood yet. Consistent with studies assigning a role of GPR30 in the cardiovascular and metabolic systems, GPR30 expression has been reported in small arterial vessels, pancreas and chief gastric cells of the stomach. Therefore, we hypothesized a role of GPR30 in the onset and progression of cardiovascular and metabolic diseases. In order to test our hypothesis, we investigated the effects of a high-fat diet on the metabolic and cardiovascular profiles of Gpr30-deficient mice (GPR30-lacZ mice). We found that GPR30-lacZ female, rather than male, mice had significant lower levels of HDL along with an increase in fat liver accumulation as compared to control mice. However, two indicators of cardiac performance assessed by echocardiography, ejection fraction and fractional shortening were both decreased in an age-dependent manner only in Gpr30-lacZ male mice. Collectively our results point to a potential role of Gpr30 in preserving lipid metabolism and cardiac function in a sex- and age-dependent fashion.
Dataset: IKMC paper 2012
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ABSTRACT: In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed high-throughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell clones and more than 1,700 mutant mouse strains, most of them conditional. A common IKMC web portal ( www.knockoutmouse.org ) has been established, allowing easy access to this unparalleled biological resource. The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.
Article: Load-Reducing Therapy Prevents Development of Arrhythmogenic Right Ventricular Cardiomyopathy in Plakoglobin-Deficient Mice[Show abstract] [Hide abstract]
ABSTRACT: We used a murine model of arrhythmogenic right ventricular cardiomyopathy (ARVC) to test whether reducing ventricular load prevents or slows development of this cardiomyopathy. At present, no therapy exists to slow progression of ARVC. Genetically conferred dysfunction of the mechanical cell-cell connections, often associated with reduced expression of plakoglobin, is thought to cause ARVC. Littermate pairs of heterozygous plakoglobin-deficient mice (plako(+/-)) and wild-type (WT) littermates underwent 7 weeks of endurance training (daily swimming). Mice were randomized to blinded load-reducing therapy (furosemide and nitrates) or placebo. Therapy prevented training-induced right ventricular (RV) enlargement in plako(+/-) mice (RV volume: untreated plako(+/-) 136 ± 5 μl; treated plako(+/-) 78 ± 5 μl; WT 81 ± 5 μl; p < 0.01 for untreated vs. WT and untreated vs. treated; mean ± SEM). In isolated, Langendorff-perfused hearts, ventricular tachycardias (VTs) were more often induced in untreated plako(+/-) hearts (15 of 25), than in treated plako(+/-) hearts (5 of 19) or in WT hearts (6 of 21, both p < 0.05). Epicardial mapping of the RV identified macro-re-entry as the mechanism of ventricular tachycardia. The RV longitudinal conduction velocity was reduced in untreated but not in treated plako(+/-) mice (p < 0.01 for untreated vs. WT and untreated vs. treated). Myocardial concentration of phosphorylated connexin43 was lower in plako(+/-) hearts with VTs compared with hearts without VTs and was reduced in untreated plako(+/-) compared with WT (both p < 0.05). Plako(+/-) hearts showed reduced myocardial plakoglobin concentration, whereas β-catenin and N-cadherin concentration was not changed. Load-reducing therapy prevents training-induced development of ARVC in plako(+/-) mice.
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ABSTRACT: The female sex hormone estradiol plays an important role in reproduction, mammary gland development, bone turnover, metabolism, and cardiovascular function. The effects of estradiol are mediated by two classical nuclear receptors, estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta). In 2005, G-protein-coupled receptor 30 (GPR30) was claimed to act as a non-classical estrogen receptor that was also activated by the ERalpha and ERbeta antagonists tamoxifen and fulvestrant (ICI 182780). Despite many conflicting results regarding the potential role of GPR30 as an estrogen receptor, the official nomenclature was changed to GPER (G-protein-coupled estrogen receptor). This review revisits the inconsistencies that still exist in the literature and focuses on selected publications that basically address the following two questions: what is the evidence for and against the hypothesis that GPR30 acts as an estrogen receptor? What is the potential in vivo role of GPR30? Thus, in the first part we focus on conflicting results from in vitro studies analysing the subcellular localization of GPR30, its ability to bind (or not to bind) estradiol and to signal (or not to signal) in response to estradiol. In the second part, we discuss the strengths and limitations of four available GPR30 mouse models. We elucidate the potential impact of different targeting strategies on phenotypic diversity.
Article: Female sex and estrogen receptor- attenuate cardiac remodeling and apoptosis in pressure overload[Show abstract] [Hide abstract]
ABSTRACT: We investigated sex differences and the role of estrogen receptor-beta (ERbeta) on myocardial hypertrophy in a mouse model of pressure overload. We performed transverse aortic constriction (TAC) or sham surgery in male and female wild-type (WT) and ERbeta knockout (ERbeta(-/-)) mice. All mice were characterized by echocardiography and hemodynamic measurements and were killed 9 wk after surgery. Left ventricular (LV) samples were analyzed by microarray profiling, real-time RT-PCR, and histology. After 9 wk, WT males showed more hypertrophy and heart failure signs than WT females. Notably, WT females developed a concentric form of hypertrophy, while males developed eccentric hypertrophy. ERbeta deletion augmented the TAC-induced increase in cardiomyocyte diameter in both sexes. Gene expression profiling revealed that WT male hearts had a stronger induction of matrix-related genes and a stronger repression of mitochondrial genes than WT female hearts. ERbeta(-/-) mice exhibited a different transcriptional response. ERbeta(-/-)/TAC mice of both sexes exhibited induction of proapoptotic genes with a stronger expression in ERbeta(-/-) males. Cardiac fibrosis was more pronounced in male WT/TAC than in female mice. This difference was abolished in ERbeta(-/-) mice. The number of apoptotic nuclei was increased in both sexes of ERbeta(-/-)/TAC mice, most prominent in males. Female sex offers protection against ventricular chamber dilation in the TAC model. Both female sex and ERbeta attenuate the development of fibrosis and apoptosis, thus slowing the progression to heart failure.
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ABSTRACT: Multiple reports implicated the function of G protein-coupled receptor (GPR)-30 with nongenomic effects of estrogen, suggesting that GPR30 might be a G-protein coupled estrogen receptor. However, the findings are controversial and the expression pattern of GPR30 on a cell type level as well as its function in vivo remains unclear. Therefore, the objective of this study was to identify cell types that express Gpr30 in vivo by analyzing a mutant mouse model that harbors a lacZ reporter (Gpr30-lacZ) in the Gpr30 locus leading to a partial deletion of the Gpr30 coding sequence. Using this strategy, we identified the following cell types expressing Gpr30: 1) an endothelial cell subpopulation in small arterial vessels of multiple tissues, 2) smooth muscle cells and pericytes in the brain, 3) gastric chief cells in the stomach, 4) neuronal subpopulations in the cortex as well as the polymorph layer of the dentate gyrus, 5) cell populations in the intermediate and anterior lobe of the pituitary gland, and 6) in the medulla of the adrenal gland. In further experiments, we aimed to decipher the function of Gpr30 by analyzing the phenotype of Gpr30-lacZ mice. The body weight as well as fat mass was unchanged in Gpr30-lacZ mice, even if fed with a high-fat diet. Flow cytometric analysis revealed lower frequencies of T cells in both sexes of Gpr30-lacZ mice. Within the T-cell cluster, the amount of CD62L-expressing cells was clearly reduced, suggesting an impaired production of T cells in the thymus of Gpr30-lacZ mice.
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ABSTRACT: Gene trapping is used to introduce insertional mutations into genes of mouse embryonic stem cells (ESCs). It is performed with gene trap vectors that simultaneously mutate and report the expression of the endogenous gene at the site of insertion and provide a DNA tag for rapid identification of the disrupted gene. Gene traps have been employed worldwide to assemble libraries of mouse ESC lines harboring mutations in single genes, which can be used to make mutant mice. However, most of the employed gene trap vectors require gene expression for reporting a gene trap event and therefore genes that are poorly expressed may be under-represented in the existing libraries. To address this problem, we have developed a novel class of gene trap vectors that can induce gene expression at insertion sites, thereby bypassing the problem of intrinsic poor expression. We show here that the insertion of the osteopontin enhancer into several conventional gene trap vectors significantly increases the gene trapping efficiency in high-throughput screens and facilitates the recovery of poorly expressed genes.
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ABSTRACT: Pressure overload (PO) first causes cardiac hypertrophy and then heart failure (HF), which are associated with sex differences in cardiac morphology and function. We aimed to identify genes that may cause HF-related sex differences. We used a transverse aortic constriction (TAC) mouse model leading to hypertrophy without sex differences in cardiac function after 2 weeks, but with sex differences in hypertrophy 6 and 9 weeks after TAC. Cardiac gene expression was analyzed 2 weeks after surgery. Deregulated genes were classified into functional gene ontology (GO) categories and used for pathway analysis. Classical marker genes of hypertrophy were similarly upregulated in both sexes (α-actin, ANP, BNP, CTGF). Thirty-five genes controlling mitochondrial function (PGC-1, cytochrome oxidase, carnitine palmitoyl transferase, acyl-CoA dehydrogenase, pyruvate dehydrogenase kinase) had lower expression in males compared to females after TAC. Genes encoding ribosomal proteins and genes associated with extracellular matrix remodeling exhibited relative higher expression in males (collagen 3, matrix metalloproteinase 2, TIMP2, and TGFβ2, all about twofold) after TAC. We confirmed 87% of the gene expression by real-time polymerase chain reaction. By GO classification, female-specific genes were related to mitochondria and metabolism and males to matrix and biosynthesis. Promoter studies confirmed the upregulation of PGC-1 by E2. Less downregulation of metabolic genes in female hearts and increased protein synthesis capacity and deregulation of matrix remodeling in male hearts characterize the sex-specific early response to PO. These differences could contribute to subsequent sex differences in cardiac function and HF. Electronic supplementary material The online version of this article (doi:10.1007/s00109-008-0385-4) contains supplementary material, which is available to authorized users.
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ABSTRACT: The prevalence and clinical manifestation of several cardiovascular diseases vary considerably with sex and age. Thus, a better understanding of the molecular basis of these differences may represent a starting point for an improved gender-specific medicine. Despite the fact that sex-specific differences have been observed in the cardiovascular system of humans and animal models, systematic analyses of sexual dimorphisms at the transcriptional level in the healthy heart are missing. Therefore we performed gene expression profiling on mouse and human cardiac samples of both sexes and young as well as aged individuals and verified our results for a subset of genes using real-time polymerase chain reaction in independent left ventricular samples. To tackle the question whether sex differences are evolutionarily conserved, we also compared sexually dimorphic genes between both species. We found that genes located on sex chromosomes were the most abundant ones among the sexually dimorphic genes. Male-specific expression of Y-linked genes was observed in mouse hearts as well as in the human myocardium (e.g. Ddx3y, Eif2s3y and Jarid1d). Higher expression levels of X-linked genes were detected in female mice for Xist, Timp1 and Car5b and XIST, EIF2S3X and GPM6B in women. Furthermore, genes on autosomal chromosomes encoding cytochromes of the monoxygenase family (e.g. Cyp2b10), carbonic anhydrases (e.g. Car2 and Car3) and natriuretic peptides (e.g. Nppb) were identified with sex- and/or age-specific expression levels. This study underlines the relevance of sex and age as modifiers of cardiac gene expression. Electronic supplementary material The online version of this article (doi:10.1007/s00109-007-0240-z) contains supplementary material, which is available to authorized users.
Article: Erratum: Splinkerette PCR for more efficient characterization of gene trap events (Nature Genetics (2007) 39, (933-934))
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ABSTRACT: NOTE: In the version of this article initially published, the second author (Jens Hansen) should have been listed as an equal contributor with the first author. The last two authors (Harald von Melchner and Patricia Ruiz Noppinger) should have been listed as corresponding authors. The error has been corrected in the HTML and PDF versions of the article.
Article: Trivedi, C. M. et al. HDAC2 regulates the cardiac hypertrophic response by modulating GSK3 activity. Nature Med. 13, 324-331[Show abstract] [Hide abstract]
ABSTRACT: In the adult heart, a variety of stresses induce re-expression of a fetal gene program in association with myocyte hypertrophy and heart failure. Here we show that histone deacetylase-2 (Hdac2) regulates expression of many fetal cardiac isoforms. Hdac2 deficiency or chemical histone deacetylase (HDAC) inhibition prevented the re-expression of fetal genes and attenuated cardiac hypertrophy in hearts exposed to hypertrophic stimuli. Resistance to hypertrophy was associated with increased expression of the gene encoding inositol polyphosphate-5-phosphatase f (Inpp5f) resulting in constitutive activation of glycogen synthase kinase 3beta (Gsk3beta) via inactivation of thymoma viral proto-oncogene (Akt) and 3-phosphoinositide-dependent protein kinase-1 (Pdk1). In contrast, Hdac2 transgenic mice had augmented hypertrophy associated with inactivated Gsk3beta. Chemical inhibition of activated Gsk3beta allowed Hdac2-deficient adults to become sensitive to hypertrophic stimulation. These results suggest that Hdac2 is an important molecular target of HDAC inhibitors in the heart and that Hdac2 and Gsk3beta are components of a regulatory pathway providing an attractive therapeutic target for the treatment of cardiac hypertrophy and heart failure.
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ABSTRACT: The sexually dimorphic differentiation of the bipotential gonad into testis or ovary initiates the sexually dimorphic development of mammals and leads to divergent hormone concentrations between the sexes throughout life. However, despite the fact that anatomic and hormonal differences between the sexes are well described, only a few studies have investigated the manifestation of these differences at the transcriptional level in mammalian somatic tissue. This review focuses on basic regulatory mechanisms of sex-specific gene expression and examines recent gene expression profiling studies to outline basic differences between the sexes at the transcriptome level in somatic tissues. To identify gene expression profiling studies addressing sexually dimorphic gene expression, the PubMed database was searched using the terms sex and dimorp and gene expression not drosophila not elegans. Abstracts of all identified publications were screened for studies explicitly using microarrays to identify sex differences in somatic tissues of rodents or humans. The search was restricted to English-language articles published in the past 5 years. Reference lists of identified articles as well as microarray databases (Gene Expression Omnibus and ArrayExpress) were also used. The application of microarray technology has enabled the systematic assessment of sex-biased gene expression on the transcriptome level, indicating that the regulatory pathways underlying sexual differentiation give rise to extensive differences in somatic gene expression across organisms. Sustainable annotation of sex-biased gene expression provides a key to understanding basic physiological differences between healthy males and females as well as those with diseases.
Top Journals
Charité Universitätsmedizin Berlin
Berlín, Berlin, Germany
- Center for Cardiovascular Research
Wellcome Trust Sanger InstituteCambridge, England, United Kingdom


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I became intrigued when I was checking out some comments that were made on an article that Dr. Mercola had written about acne prevention and treatment through diet, which lead me to a few other articles about sunblock and why it's not the best thing to be a true vampire and just stay out of the sun all the time. He says that the sun offers healing effects and supplies us with much needed Vitamin D, which he and several others are convinced helps to prevent different types of cancers. However, he is also careful to add that too much sun exposure can also cause cancer.
I was reading some readers comments about natural sun blocks, that don't contain any chemicals or phycial barriers in them (like zinc oxide, which really protects your skin because it is a thick, chalky substance, not a thin chemical laced concoction like most sunblocks, nonetheless, it's not very attractice admittedly), that may be plant based or almost a home remedy type of thing. One of the readers said that she has been using cocounut oil for a while, and although she is fair skinned, she never burns using it.
However, she also admitted that she wasn't in the sun for long periods of time either. So, can coconut oil, or even sesame oil, another rumored sunblock that is natural, really block the sun's dangerous UV rays and help protect your skin against sun damage and ultimately certain types of skin cancer that are typically caused by excessive sun exposure? Well, I read a few other items on the internet after running across that, curious if my fair skin may be able to start using a natural sunblock, since I eschew the chemical variety. They seem to always give me some sort of adverse reaction, whether it is breaking out, itching, or running into my eyes and burning.
So, apparently sesame oil may offer a tad better protection than coconut oil, which by the way has to be virgin coconut oil ot work as a sunblock, blocks around 20% of the sun's harmful rays, and sesame oil is supposed to block about 30% of the sun's harmful UV rays. I'm not sure where these figures come from, or honestly if they are even accurate, but that is what I had found out about them. Now, another person posted somewhere that they burned when they put coconut oil on, but they also admitted this was when they were purposefully baking themselves for long periods of time in the peak sun hours.
If anyone who has any experience with using either coconut oil as a sunscreen protectant, or sesame oil as a sunscreen, please do post here a comment and let other interested readers know your experience or your knowledge on the subject. I'd really like to know as well, summer is upon us and I'd love to have a natural alternative to yucky traditional sunscreens.
This entry was posted on Monday, April 6th, 2009 at 8:20 pm and is filed under Home Remedies. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.

subset: commoncrawl


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The Emporio Armani 9087 glasses have a black acetate frame and on the inside of the frame front is a very pretty, sparkly lime green. These small glasses do not have spring hinges, but there is slight flexibility in the arms for a comfortable fit. The Emporio Armani 9087 are perfect for any young girl with a great sense of style.
Emporio Armani is the only Armani diffusion line that is still designed primarily by Giorgio Armani. The Emporio line has always been one step ahead of the next trend and is the perfect balance of modern refinement and unique vintage-inspired finishes. The metropolitan styling and contemporary vibe embodied by this collection are in the true spirit of Emporio Armani, right down to the signature eagle logo.


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Item # 6870160
- Heather grey jersey sneakers with iridescent rhinestone embellishments
- Elastic gores for slip-on fit
- Padded for extra comfort
- Online Exclusive!
Fabric care & other information
- Imported
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Some things just GO together!
Embellished Jersey Slip On Shoes 1 2
Love these shoes These shoes are absolutely my daughters favorite shoes, she says they are so comfy we are on our 2nd pair. The only bad thing about these shoes are the glue around the rubber and the cloth material it could be put together better. But overall love, love them I wish they came in my size but my daughter is so glad they don't March 27, 2014
1-2 of 2


text: Comments (20) + Add comment Comments (20) Featured joeyisback 1223d ago | Trolling | show hennessey86 + 1223d ago I have been havingProblems, it's saying its my nat type but I no it isn't #2 Agree(4) | Disagree(5) | Report | Reply ChunkyLover53 + 1223d ago I write this comment from IE on my Xbox dashboard! #3 Agree(7) | Disagree(12) | Report | Reply aviator189 + 1223d ago I'm currently on Live as well. No problems from my end in Texas. And the usual number of my friends are online as well. Edit: It may have been down prior to the approval of this submission, but the xbox live status is green-lit apart from the crackle app so it should be fully working now for whoever had any problems. - http://support.xbox.com/en-... #3.1 (Edited 1223d ago ) | Agree(4) | Disagree(4) | Report | Reply AngelicIceDiamond + 1223d ago I signed in just fine to. Nice weather we're having in TX I must say. #3.1.1 Agree(2) | Disagree(1) | Report Locksus + 1223d ago Well, I'm having no problems but really, Microsoft? Is this what people pay 50 euros a month for? The least I expect is a stable connection. *EDIT* Sorry, I meant to say 50 euros a year. #4 (Edited 1223d ago ) | Agree(5) | Disagree(14) | Report | Reply Blankman85 + 1223d ago Tell me one paid service that never experiences any hitches whatsoever. I'll wait. I was under the impression that the media didn't report xbox live downtimes. Well at least thats what you hear on n4g everytime PSN is down, that the media is biased and makes a big deal bout every PSN outage only. #4.1 Agree(6) | Disagree(5) | Report | Reply Locksus + 1223d ago "Tell me one paid service that never experiences any hitches whatsoever." Was not my point. I still expect a good stability of the service if I'm paying for one. Anyways, not a big deal for me as this doesn't affect me but thought I'd just share what I think about it. #4.1.1 Agree(0) | Disagree(8) | Report turnerdc + 1223d ago Yeah, because we live in a perfect world where nothing ever goes wrong with servers, electricity, software, and employees. And to think, all those cell phone carriers that experience service outages occasionally (all of them) are charging people 60 - 100+ dollars a month. #4.2 (Edited 1223d ago ) | Agree(6) | Disagree(2) | Report | Reply aviator189 + 1223d ago Dude, nothing comes without some hitches. Things go wrong due to complex tech in a potentially unstable environment where numerous external factors are in play. If we lived in world where everything worked perfectly and experienced no technical glitches or set-backs, oh my what a world that would be. This Live outage lasted for a mere 3-10 minutes according to some people over on the forums and kotaku posts. Are you telling me that waiting such a short amount of time is so grueling? #4.3 (Edited 1223d ago ) | Agree(2) | Disagree(2) | Report | Reply Getowned + 1223d ago well, you get what you pay for.. lol jk... no, seriously I know how hard it sucks to come home from a hard day of work/school and be confronted with a downed network.. at these times I normally quote Darth vader "NOOoooOOooooOOOOOOOOoooo oo" http://www.youtube.com/watc... and than I sit in a corner rocking back and forth like a crack addit going through withdrawals. #4.4 Agree(0) | Disagree(2) | Report | Reply Ben_Grimm + 1223d ago Wow a lot of Kotaku articles being approved on n4G at the moment. Why the change of heart for this website? #5 Agree(4) | Disagree(4) | Report | Reply Anon1974 + 1223d ago When have Kotaku articles not been approved on n4g? #5.1 Agree(3) | Disagree(3) | Report | Reply Ben_Grimm + 1223d ago A lot of posters on here were calling for a ban of Kotaku for some reason. But so far we have had at least three submitted today. #5.1.1 Agree(3) | Disagree(3) | Report vividi + 1223d ago this comment is pathetic LOL , people dont have more interesting things to do? #5.2 Agree(1) | Disagree(2) | Report | Reply CernaML + 1223d ago Seriously. Ben_Grimm's obsession on trying really hard to prove that this site is some Sony fanboy haven is really pathetic. #5.2.1 Agree(1) | Disagree(5) | Report TheColbertinator + 1223d ago Its working fine for me.Then again I haven't used it for months so... #6 Agree(0) | Disagree(3) | Report | Reply Cam977 + 1223d ago Stop verifying articles like this please, it's irritating! 'Oh no, I can't play online due to some error, better get an article out' - NO. #7 Agree(4) | Disagree(1) | Report | Reply jaixvx + 1223d ago Someone stole my xbl account..again. And now live is down. Awesome! #8 Agree(1) | Disagree(5) | Report | Reply MasterD919 + 1223d ago I got the warning that I couldn't connect to Live while playing BL2...and then I signed in again and it worked fine. By the time people catch wind of this "issue" it will have been resolved most likely. #9 Agree(1) | Disagree(1) | Report | Reply Add comment You need to be registered to add comments. Register here or login Username Password Remember Rules & guidelines Login


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Snow.Storm by Colours07Watch
©2011-2016 Colours07
Took me a week to do this and I messed this up and gave up on it.
;A; I just don't understand colouring.
;A; I just don't understand colouring.
Looking again: Wiccan is killing me. He's so HANSOME!!
I LOOOOVE Wiccan on this!! (even more than usual I mean)
My god, I know Tim is kind of supposed to be the focus of this picture and he looks fantastic, but I can't keep my eyes off BILLY. My god, he looks amazing.
I love the coloring in this one. One persons mess up is another persons perfection!
Holy crap. That's amazing!
OMG Abby!!! Upload this on tumblr Omg this is amazing
Omg! Pretty, pretty colors!!
It's so pretty and shiny...
I think you did an awesome job coloring it! O: The colors are very pretty.
And haha, Billy in the background <3
And haha, Billy in the background <3
i really like the match up!
well i think you did a fine job! :")
you 'don't understand coloring'? how ironic cuz your username is colours07 :'D
but i love the colors!!<3 they're so pretty!! *o*
but i love the colors!!<3 they're so pretty!! *o*
This is amazing, as all of your art is
This is so pretty... the colors are amazing. And Billy is just so pretty back there.
Billy!!!! XD
*A* these two beautiful boys....I love how you have drwn Billy by the way...and the colours are so pretty
I likes the colors..


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You are here:
EPA Region 6 has limited storage space for hardcopies of permitting related documents. Therefore, we request that permit applicants submit copies of permit applications, permit addenda, and permit related air quality modeling data to EPA in a searchable Portable Document Format (PDF) or Microsoft Word on a compact disk (CD) or FlashDrive by mail to the EPA Contact listed below and/or send copies, properly identified by (facility name, state, type of permit or action requested), of those same files via email .
- Arkansas Program Contact: Ashley Mohr, Phone (214) 665-7289
- Louisiana Program Contact: Brad Toups, Phone (214) 665-7258
- New Mexico Program Contact: Randy Pitre, Phone (214) 665-7299
- Oklahoma Program Contact: Dinesh Senghani, Phone (214) 665-7221
- Texas Program Contact: Stephanie Kordzi, Phone (214) 665-7520
The following Topics included in Permitting under the Clean Air Act (CAA) have migrated to the new EPA website:
- Tribal NSR Permitting
- Part 71 Title V Operating Permits
- Title V Petitions
- GHG PSD Permit Rescissions in Texas
Part 70 Title V Operating Permits Program in Region 6 States
- Arkansas
- Louisiana
- New Mexico
- Oklahoma
- Texas
PSD GHG Permits Issued by EPA
Warning! Due to changes in EPA's website on October 1, 2015, all the PDFs listed in the table below have been archived. If the links to those files no longer work, you should be able to find them by searching for: the "Applicant's Name" from column 1 + "GHG" + "Texas" at: http://archive.epa.gov/


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Mark 7:21-23New International Version (NIV)
21 For it is from within, out of a person's heart, that evil thoughts come—sexual immorality, theft, murder, 22 adultery, greed, malice, deceit, lewdness, envy, slander, arrogance and folly. 23 All these evils come from inside and defile a person."
New International Version (NIV)
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Archive for the 'R' Category
A recent trend on Facebook is to create a wordcloud of all of your posts using an external service. I chose not to use it because I tend to use Facebook for personal interactions among close friends and I didn't want to send all of my data to another external company.
Twitter is a different matter, however! All of the data is open and it's very easy to write a computer program to generate Twitter world clouds without the need for an external service.
I wrote a simple script in R that generates a wordcloud from the most recent 3200 tweets and outputs the top 200 words (get the code on github). The script removes many of the uninteresting words such as the, of, and that would otherwise dominate the cloud. These stopwords come from the Top100Words list of the R package qdap but I also added a few more such as 'just' and 'me' that I seem to use a lot.
This is the current wordcloud for my twitter account, walkingrandomly. Click on the image to see a bigger version. My main interests are very clear – Python programming, research software, data and anything that's new!
Once I had seen my wordcloud, I wondered how things would look for other twitter users who I pay a lot of attention to. This is how it looks for Manchester University's Nick Higham. Clearly he's big on SIAM, Manchester, and Matrix Analysis!
I then looked at my manager at Sheffield University, Neil Lawrence. Neil finds data and the city of Sheffield very important and also writes about workshops, science, blog posts and machine learning a lot.
The R code that generated these wordclouds is available on github but it won't work out of the box. You'll need to register with twitter for app development (It's free and fairly straightforward) and get various access keys before you can use the code.
I recently found myself in need of a portable install of the Jupyter notebook which made use of a portable install of R as the compute kernel. When you work in institutions that have locked-down managed Windows desktops, such portable installs can be a life-saver! This is particularly true when you are working with rapidly developing projects such as Jupyter and IRKernel.
It's not perfect but it works for the fairly modest requirements I had for it. Here are the steps I took to get it working.
Download and install Portable Python
I downloaded Portable Python 126.96.36.199 from http://portablepython.com/ and installed into a directory called Portable Python 188.8.131.52
Update IPython and install the extra modules we need
This version of Portable Python comes with a portable IPython instance but it is too old to support alternative kernels. As such, we need to install a newer version.
Open a cmd.exe command prompt and navigate to Portable Python 188.8.131.52\App\Scripts.
Enter the command
easy_install ipython.exe
You'll now find that you can launch the ipython.exe terminal from within this directory:
C:\Users\walkingrandomly\Desktop\Portable Python 126.96.36.199\App\Scripts>ipython Python 2.7.6 (default, Nov 10 2013, 19:24:18) [MSC v.1500 32 bit (Intel)] Type "copyright", "credits" or "license" for more information. IPython 3.1.0 -- An enhanced Interactive Python. ? -> Introduction and overview of IPython's features. %quickref -> Quick reference. help -> Python's own help system. object? -> Details about 'object', use 'object??' for extra details. In [1]: exit()
If you try to launch the notebook, however, you'll get error messages. This is because we haven't taken care of all the dependencies. Let's do that now. Ensuring you are still in the Portable Python 220.127.116.11\App\Scripts folder, execute the following commands.
easy_install pyzmq easy_install jinja2 easy_install tornado easy_install jsonschema
You should now be able to launch the notebook using
ipython notebook
Install portable R and IRKernel
- I downloaded Portable R 3.2 from http://sourceforge.net/projects/rportable/files/ and installed into a directory called R-Portable
- Move this directory into the Portable Python directory. It needs to go inside Portable Python 22.214.171.124\App (see this discussion to learn how I discovered that this location was the correct one)
- Launch the Portable R executable which should be at Portable Python 126.96.36.199\App\R-Portable\R-portable.exe and install the IRKernel packages by doing
install.packages(c("rzmq","repr","IRkernel","IRdisplay"), repos="http://irkernel.github.io/")
Install additional R packages
The version of Portable R I used didn't include various necessary packages. Here's how I fixed that.
- Launch the Portable R executable which should be at Portable Python 126.96.36.199\App\R-Portable\R-portable.exe and install the following packages
install.packages('digest') install.packages('uuid') install.packages('base64enc') install.packages('evaluate') install.packages('jsonlite')
Install the R kernel file
Create the directory structure Portable Python 184.108.40.206\App\share\jupyter\kernels\R_kernel
Create a file called kernel.json that contains the following
{"argv": ["R-Portable/App/R-Portable/bin/i386/R.exe","-e","IRkernel::main()", "--args","{connection_file}"], "display_name":"Portable R" }
This file needs to go in the R_kernel directory created earlier. Note that the kernel location specified in kernel.json uses Linux style forward slashes in the path rather than the backslashes that Windows users are used to. I found that this was necessary for the kernel to work –it was ignored by the notebook otherwise.
Finishing off
Everything created so far, including R, is in the folder Portable Python 2.7.6
I created a folder called PortableJupyter and put the Portable Python 2.7.6 folder inside it. I also created the folder PortableJupyter\notebooks to allow me to carry my notebooks around with the software that runs them.
There is a bug in Portable Python 188.8.131.52 relating to scripts like IPython.exe that have been installed using easy_install. In short, they stop working if you move the directory they're installed in – breaking portability somewhat! (Details here)
The workaround is to launch Ipython by running the script Portable Python 184.108.40.206\App\Scripts\ipython-script.py
I didn't want to bother with that so created a shortcut in my PortableJupyter folder called Launch notebook. The target of this shortcut was the following line
%windir%\system32\cmd.exe /c "cd notebooks && "%CD%/Portable Python 220.127.116.11/App\python.exe" "%CD%/Portable Python 22.214.171.124\App\Scripts\ipython-script.py" notebook"
This starts the notebook using the default web browser and puts you in the notebooks directory.
The pay off
My folder looks like this:
If I click on the Launch Notebook shortcut, I get a Jupyter session with 2 kernel options
I can choose the Portable R kernel and start using R in the notebook!
RLink is Mathematica's interface to the R language – a feature that has been extremely popular since its debut in Mathematica version 9. It's a great package but has one or two issues. For example, RLink makes use of a built in version of R which is currently stuck at the rather old version 2.14. Official support for the use of external versions of R and adding third-party libraries varies by operating system and version of Mathematica. Windows support is great — OS X support, not so much.
Expert Mathematica user Szabolcs Horvát has written the definitive guide on how to get RLink up and running with the latest version of R on all three major operating systems, building on earlier work by Leonid Shifrin and members of the Mathematica Stack Exchange community. Thanks to this work, we can now enjoy any version of R we like with Mathematica!
A colleague recently sent me the following code snippet in R
> a=c(1,2,3,40) > b=a[1:10] > b [1] 1 2 3 40 NA NA NA NA NA NA
The fact that R didn't issue a warning upset him since exceeding array bounds, as we did when we created b, is usually a programming error.
I'm less concerned and simply file the above away in an area of my memory entitled 'Odd things to remember about R' — I find that most programming languages have things that look odd when you encounter them for the first time. With that said, I am curious as to why the designers of R thought that the above behaviour was a good idea.
Does anyone have any insights here?
The R code used for this example comes from Barry Rowlingson, so huge thanks to him.
A question I get asked a lot is 'How can I do nonlinear least squares curve fitting in X?' where X might be MATLAB, Mathematica or a whole host of alternatives. Since this is such a common query, I thought I'd write up how to do it for a very simple problem in several systems that I'm interested in
This is the R version. For other versions,see the list below
- Simple nonlinear least squares curve fitting in Julia
- Simple nonlinear least squares curve fitting in Maple
- Simple nonlinear least squares curve fitting in Mathematica
- Simple nonlinear least squares curve fitting in MATLAB
- Simple nonlinear least squares curve fitting in Python
The problem
xdata = -2,-1.64,-1.33,-0.7,0,0.45,1.2,1.64,2.32,2.9 ydata = 0.699369,0.700462,0.695354,1.03905,1.97389,2.41143,1.91091,0.919576,-0.730975,-1.42001
and you'd like to fit the function
using nonlinear least squares. You're starting guesses for the parameters are p1=1 and P2=0.2
For now, we are primarily interested in the following results:
- The fit parameters
- Sum of squared residuals
- Parameter confidence intervals
Future updates of these posts will show how to get other results. Let me know what you are most interested in.
Solution in R
# construct the data vectors using c() xdata = c(-2,-1.64,-1.33,-0.7,0,0.45,1.2,1.64,2.32,2.9) ydata = c(0.699369,0.700462,0.695354,1.03905,1.97389,2.41143,1.91091,0.919576,-0.730975,-1.42001) # look at it plot(xdata,ydata) # some starting values p1 = 1 p2 = 0.2 # do the fit fit = nls(ydata ~ p1*cos(p2*xdata) + p2*sin(p1*xdata), start=list(p1=p1,p2=p2)) # summarise summary(fit)
This gives
Formula: ydata ~ p1 * cos(p2 * xdata) + p2 * sin(p1 * xdata) Parameters: Estimate Std. Error t value Pr(>|t|) p1 1.881851 0.027430 68.61 2.27e-12 *** p2 0.700230 0.009153 76.51 9.50e-13 *** --- Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 Residual standard error: 0.08202 on 8 degrees of freedom Number of iterations to convergence: 7 Achieved convergence tolerance: 2.189e-06
Draw the fit on the plot by getting the prediction from the fit at 200 x-coordinates across the range of xdata
new = data.frame(xdata = seq(min(xdata),max(xdata),len=200)) lines(new$xdata,predict(fit,newdata=new))
Getting the sum of squared residuals is easy enough:
Which gives
[1] 0.0538127
Finally, lets get the parameter confidence intervals.
Which gives
Waiting for profiling to be done... 2.5% 97.5% p1 1.8206081 1.9442365 p2 0.6794193 0.7209843
I was recently working with someone who was running thousands of R jobs on our Condor pool and some of them were failing. As part of the diagnostic process, we needed to determine which machines in the pool were causing the problem. My solution was to add the line
To the Bash script that eventually called R and the program he was running. This gives output that looks like this
His solution was to do exactly the same thing in R. To do this, he added the following line to the beginning of his R script
Which produces output that looks like
nodename "badmachine.ourdomain.ac.uk"
Either way, the job was done.
R has a citation() command that recommends how to cite the use of R in your publications, information that is also included in R's Frequently Asked Questions document.
To cite R in publications use: R Core Team (2012). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0, URL http://www.R-project.org/. A BibTeX entry for LaTeX users is @Manual{, title = {R: A Language and Environment for Statistical Computing}, author = {{R Core Team}}, organization = {R Foundation for Statistical Computing}, address = {Vienna, Austria}, year = {2012}, note = {{ISBN} 3-900051-07-0}, url = {http://www.R-project.org/}, } We have invested a lot of time and effort in creating R, please cite it when using it for data analysis. See also 'citation("pkgname")' for citing R packages
This led me to wonder how often people cite the software they use. For example, if you publish the results of a simulation written in MATLAB do you cite MATLAB in any way? How about if you used Origin or Excel to produce a curve fit, would you cite that? Would you cite your plotting software, numerical libraries or even compiler?
The software sustainability institute (SSI), of which I recently became a fellow, has guidelines on how to cite software.
xkcd is a popular webcomic that sometimes includes hand drawn graphs in a distinctive style. Here's a typical example
In a recent Mathematica StackExchange question, someone asked how such graphs could be automatically produced in Mathematica and code was quickly whipped up by the community. Since then, various individuals and communities have developed code to do the same thing in a range of languages. Here's the list of examples I've found so far
- xkcd style graphs in Mathematica. There is also a Wolfram blog post on this subject.
- xkcd style graphs in R. A follow up blog post at vistat.
- xkcd style graphs in LaTeX
- xkcd style graphs in Python using matplotlib
- xkcd style graphs in MATLAB. There is now some code on the File Exchange that does this with your own plots.
- xkcd style graphs in javascript using D3
- xkcd style graphs in Euler
- xkcd style graphs in Fortran
Any I've missed?
My attention was recently drawn to a Google+ post by JerWei Zhang where he evaluates 2^3^4 in various packages and notes that they don't always agree. For example, in MATLAB 2010a we have 2^3^4 = 4096 which is equivalent to putting (2^3)^4 whereas Mathematica 8 gives 2^3^4 = 2417851639229258349412352 which is the same as putting 2^(3^4). JerWei's post gives many more examples including Excel, Python and Google and the result is always one of these two (although to varying degrees of precision).
What surprised me was the fact that they disagreed at all since I thought that the operator precendence rules were an agreed standard across all software packages. In this case I'd always use brackets since _I_ am not sure what the correct interpretation of 2^3^4 should be but I would have taken it for granted that there is a standard somewhere and that all of the big hitters in the numerical world would adhere to it.
Looks like I was wrong!
I was recently given the task of converting a small piece of code written in R, the free open-source programming language heavily used by statisticians, into MATLAB which was an interesting exercise since I had never coded a single line of R in my life! Fortunately for me, the code was rather simple and I didn't have too much trouble with it but other people may not be so lucky since both MATLAB and R can be rather complicated to say the least. Wouldn't it be nice if there was a sort of Rosetta Stone that helped you to translate between the two systems?
Happily, it turns out that there is in the form of The MATLAB / R Reference by David Hiebeler which gives both the R and MATLAB commands for hundreds of common (and some not so common) operations.
While flicking through the 47 page document I noted that there are a few MATLAB commands for which David hasn't found an R equivalent (possibly because there simply isn't one of course). For example, at number 161 of David's document he describes the MATLAB command
which he describes as
'Fit cubic spline with "not-a-knot" conditions (the first two piecewise cubics coincide,as do the last two), to points (xi , yi ) whose coordinates are in vectors x and y; evaluate at points whose x coordinates are in vector xx, storing corresponding y's in yy.'
At the moment David doesn't know of an R equivalent so if you are a R master then maybe you could help out with this extremely useful document?


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Source: French Brothers Boat Cruises
French Brothers Boat Cruises is now offering a return Thames boat trip for two from Runnymede to Windsor, for £17.50 per person. You'll get to enjoy a cream-tea hamper during your journey, and explore the historic town for a few hours, before heading back to the Runnymede boathouse.
11am Wed, Fri-Sun 9 Apr-11 Sep
Source: Uber
You can now get up to £16 free credit to use on your first ride with Uber -- a private driver service, ordered via an app on your smartphone.
Download app & use credit by 29 Feb, 2016
Please go to your email and confirm your subscription.


text:
vegan menu, not authenticPosted on 05 / 26 / 2015
This place isn't authentic Japanese cuisine, but they don't claim to be! Has a separate vegan menu which is always a plus. The veggie cake is delicious (love any place that serves a vegan tempura!). Prices aren't great but everything is filling. A good option if in the area.


text:
See our store section for gifts by different stores
See our top gift ideas section for most popular items.
Create your own personal gift registry. Register for any item, from any store, for any occasion. Find the gift registries of your family and friends.
Ever find the perfect gift idea for someone, but their birthday was months away? We make it easy to remember your gift ideas.
Provides timely email reminders for a birthday, anniversary, and other special occasions.
Get advice from friends and family on which gifts to buy.
The Great Garden Gnome Massacre Statue
Heavy Metal Rock Band Figure
Skel-e-Dog Garden Statue
Helmet The Turtle
Skel-e-Gnome Garden Sculpture
Breast Cancer Awareness Beach Towel
Shotgun Shell Christmas Lights


text:
Jury Selected in Boot Camp Trial
Updated: 09/27/2007 - The jury of ten, including four alternates, has been sworn in.
Updated: 09/27/2007 - The jury of ten, including four alternates, has been sworn in.
Updated: 09/27/2007 - It's time for this year's CAN-paign, a national competition to see who can collect the most aluminum cans.
Updated: 09/27/2007 - Wednesday commissioners approve Tallahassee's multi-million-dollar budget. Along with it come major cuts they've been talking about all summer long.
Updated: 09/27/2007 - Georgia receives more than $3.9 million to fight DUI and motorcycle crash deaths.
Updated: 09/27/2007 - Two athletic department academic assistance employees have resigned and 23 Florida State University athletes were implicated in cheating on tests given over the Internet, school officials said Wednesday.
Updated: 09/26/2007 - Wild Adventures theme park is changing hands ... after it was bought off the auction block. The Valdosta attraction is considered one of the top fifty theme parks in the country.
Posted: 09/26/2007 - A new study finds once someone is labeled a criminal, he or she is more likely to re-offend. The landmark study by FSU professors looked at the effects of being labeled a "convicted felon".
Updated: 09/27/2007 - The death of a 19-year-old University of South Florida student from meningitis is sending shock waves throughout the university community.
Posted: 09/26/2007 - The property tax debate is really heating up. City leaders came out swinging against the house republican proposal. But the house majority leader fought back today in Cairo.
Updated: 09/26/2007 - The Wakulla County Sheriff's Office will be getting some extra help as County Commissioners have approved adding six new correctional officer positions.
Updated: 09/26/2007 - If you've ever complained about Tallahassee traffic, we've got some good news. At least one of the many construction projects is finished ahead of schedule.
Updated: 09/27/2007 - If you're looking for a new friend, Best Friends Dog Resuce has pets you can adopt.
Updated: 09/26/2007 - A Grady County insurance company is in hot water after an undercover sting.
Updated: 09/26/2007 - Share the road is the message coming from many cyclists these days, and it's catching on with the younger generation.
Updated: 09/26/2007 - The Commission meeting is underway and budget cuts are on the agenda.
Updated: 09/26/2007 - The state is appealing a court ruling removing an amendment that would cut property taxes.
Updated: 09/26/2007 - Insurance agents are getting lots of calls about the off again, maybe on again insurance coverage.
Updated: 09/26/2007 - A woman and her baby were taken to the hospital after emergency crews discovered a gas leak at her home.
Updated: 09/26/2007 - Two women fled out a back door when a masked gunman walked in the front door.
Updated: 09/26/2007 - Westminster Oaks is showing older adults how to age right. The retirement community says the best way to age is to age actively.
Updated: 09/26/2007 - Armed men forced owners into home to grab cash.
Updated: 09/26/2007 - According to the FBI, the increase in murders and robberies has pushed Florida's crime rate up 2.3 percent in 2006.
Updated: 09/26/2007 - Gadsden County commissioners voted Tuesday night to hold off on approving next year's budget.
Updated: 09/26/2007 - It's official: the newest company to relocate to Tallahassee is open for business.
Updated: 09/25/2007 - A new Florida law may have you hitting the roof to put a roof over your head. The law is supposed to make your home more storm-proof, but it will also boost your bill.


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I decide to make a excel spreadsheets so I can keep track of how far I ride and my average speed in mph to see if it gose up over time. The spreadsheet has 12 tabs one for each month.
I am posting it here to see if anyone will find it useful. If you do I will take advice and add what I can to it.
I am thinking of adding a calorie calculator but not sure what to base it on distance or time l tryed both and got a big descepancy between the 2 reults they gave
There is few minor bugs in it at the moment
1. You have to enter your time in min not hours because excel dose not work tell with times.
2. If you cycle for more than 24 hours in a month the total time in hours counter will reset because it tihnks its a 24 hour clock if anyone knows how to get round this please post it here.
3. Every month has 31 days because I copyed and pasted and can not be bothered correcting it.
all feedback welcome good or bad.
the file is in excel 97-2003 format as not that many people are useing 2007 yet and you can't buy it


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Myofunctional therapy helps correct thumb or finger sucking habits, incorrect tongue resting posture, tongue thrust swallowing patterns, open mouth rest posture and mouth breathing. It helps guide teeth into a more desirable relationship during a child's early development (before the age of 12) and enhances appearance and posture.
Though Brazil has more than 29 doctoral programs in Orofacial Myofunctional Therapy, the United States lags far behind. But awareness is growing – partly because many dental practitioners have moved into it after observing the astounding numbers of clients with likely sleep apnea, at least 90% of whom have not been diagnosed. Since stroke risk, inflammatory changes to blood and blood vessel walls, adrenal fatigue, and other downstream consequences cause a 26-fold increased risk of death than someone without sleep apnea, those "in the know" and who are responsible for treating it are alarmed! Seeking answers, they are studying the causes.
In the United States, registered dental hygienists, dentists, and speech therapists can train to become myofunctional therapists. Each seems to have a different "twist" to their therapy and their reasons for it. The introduction to orofacial myofunctional therapy here best explains my understanding, interests and private practice focus in developing a proper airway, "freeway space" for the tongue, helping establish proper breathing habits, tongue position, a correct swallow, re-patterning oral and facial muscles, and so on.
I carefully evaluate each client during the first appointment, so I can address their concerns, goals, and formulate a treatment plan. I also evaluate motivation, since it is a crucial element of success.
Though each person has individual concerns, most concentrated therapy can be accomplished in 9-10 biweekly appointments, with appointments scheduled monthly or bimonthly after that for up to a year. Most clients can establish these new neuromuscular habits within a year.
Children as young as 4 can benefit, but 7-8 is an ideal age to begin and be successful. Teens and adults may have completed their facial development but can still benefit in numerous ways. For instance, faces can continue to elongate over time, decreasing space for the tongue and airway, leading to apnea, jaw joint (TM) difficulties and other problems.
Academy of Orofacial Myofunctional Therapy Member [AOMT]
Contact Carol to set up an appointment. If I am working with you remotely [Skype/Facetime], it is helpful for you to take a few images ahead of time for me. Click Remote Evaluation MMMT I and Remote Evaluation II for guidance.


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StartUpHire is the place to find Integration Developer jobs. Review the list of Integration Developer career opportunities to the left. These Integration Developer jobs represent some of the most rewarding careers available.
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text:
Kory Lichtensteiger said he hopes to return to the Redskins in 2013, but the pending unrestricted free agent also acknowledged that the business side of football is not always that simple.
"At this point, I'm going to be going into my sixth year," he said as players cleared out their lockers at Redskins Park after the team's playoff loss to Seattle. "I'm not a young guy anymore. So you want to get something that can set you up pretty good for later in life, take care of your family."
"But," the starting left guard added, "at the same time, you want to be happy where you're working. I feel I'm definitely going to be the most happy working here and playing for Mike [Shanahan] and being a Redskin."
Lichtensteiger is coming off a strong season during which he proved himself to be a veteran leader on an offensive line that paved the way for the league's top rushing offense. According to NFL statistics, in fact, Robert Griffin III and Alfred Morris were most productive when carrying the ball to the left side of the line behind Lichtensteiger and Pro Bowl tackle Trent Williams.
Lichtensteiger was also strong in pass protection. ProFootballFocus.com only faulted him for one of the 33 sacks absorbed by Redskins' quarterbacks as well as only five quarterback hits and 14 hurries.
In December, the 27-year-old was named the team's recipient of the Ed Block Courage Award in recognition of his perseverance. He missed all but five games in 2011 after tearing two ligaments in his knee, then underwent a second procedure in training camp before returning to the lineup in September.
The only blemishes on Lichtensteiger's 2012 campaign were his propensity for penalties – he was flagged a team-high 11 times – and his ill-fated decision to attempt to play against the Seahawks despite a sprained ankle. He ended up leaving the game in the first quarter after aggravating the injury, which he said will not require surgery and should be healed in two to three weeks.
"I think if it was a normal, regular season game, I would have realized, 'Hey, I should give it another week or two,'" he said. "I really wanted to be out there and probably didn't make the right decision."
In 2010, Lichtensteiger was the first acquisition of the Shanahan regime. And based on his performance this season, he hopes to be a priority once again.
"I don't want to leave this system, I don't want to leave these coaches and I don't want to leave my teammates," he said. "So the best-case scenario for me is that I get a new deal here. But at the same time, you have to explore all the options. So, I'll just see what happens and see who wants to talk to me and, like I said, hopefully I'll be back here."


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TennisForum.com (http://www.tennisforum.com/)
- Tennis Slovenia (http://www.tennisforum.com/670-tennis-slovenia/)
- - US open! (http://www.tennisforum.com/670-tennis-slovenia/313003-us-open.html)
US open!
There should be a special thread :p
She is the 22nd seed in the competition.Hopefully she can have a great tournament, and reach a 4th round :smash: :p
In doubles she'll probably be 3rd seed along with Ai Sugiyama.Hopefully another final at least :D
Re: US open!
I'm going so you can expect photos :)
Re: US open!
Great! So if Daniilidou and Srebotnik play simultaneously, I'll go cover
Eleni, right? ;)
Re: US open!
Re: US open!
Her section:
Katarina Srebotnik SLO (22) vs. Alicia Molik AUS
Maria Kirilenko RUS vs. Martina Muller GER
Jelena Kostanic Tosic CRO vs. Elena Vesnina RUS
Julia Vakulenko UKR vs. Daniela Hantuchova SVK (9)
I kinda sensed she'd get Hantuchova in round 3 again. Hopefully she can reach it and get some revenge. The draw is not the easiest, but managable.
Re: US open!
Tough draw :(
I'm mad that Kata, Dani & Elena V are all in same part of it...
May the best woman get out of it ;)
I wonder if Ai & Kata will play mixed :confused: Kata with Nenad? :inlove: Nice guy.
Re: US open!
Awful draw.
Just when you see Molik in first round, you think: She's not in the best form, she's beatable.
And then you see Kirilenko 2nd round... :bolt: And she's in form.But hopefully a 3rd round, and Hantuchova isn't toughest of the seeds right now, so good 3rd round draw I think :yeah: , because Hantuchova isn't in her biggest form...
Re: US open!
Doubles is also rather difficult:
(3) Ai & Kata vs. Ji/Sun
Krajicek/Radwanska vs. Hradecka/Voracova
Dellacqua/Pratt vs. (WC) Barte/Mueller
(WC) Haynes/Rolle vs. (15) King/Loit
other teams in their quarter: husarova/schnyder, (7) safina/dechy, petrova/vaidisova, (12) garbin/peer :eek:
Tough section indeed.
In Black/Huber's half of the draw, too.
Re: US open!
Kata def Molik 6-2, 6-2! Nice easy win! Next up is Kirilenko! Should be a good match! Good luck Kata!
Re: US open!
Great smooth win today and with Hantuchova out, Kata has a perfect chance to finally reach that cursed 4th round again, having said that I'm not holding my breath just yet. :o
One step at a time, Kirilenko next, Kata already beat her this summer, hopefully she can do it again.
Re: US open!
Really nice win over Molik :worship:
Now, get to 3RD!
One step at a time :cool:
Ah, that's too bad about mixed - hopefully singles and doubles results are worthy of this decision! (that is: R16 & WIN :p:D:angel:)
Re: US open!
Great win over Molik.It was kinda unexpected, that easy.
She really has the 4R chance.Just that this time her bigggest hurdle is in the second round, Kirilenko.
Good luck today in doubles =)
Re: US open!
I really really really hope she beats Kirilenko, all the talk in GM is about how Kirilenko is already in r3, no one even mentions the possibility of Kata getting there, they all just talk about Vakulenko vs. Kirilenko in r3 or some other crap like that. So I really hope Kata does the talking on the court and beats Kirilenko again, I wouldn't mind another bagel like in Stanford, but in the end any win would do. Gremo!
Re: US open!
I only saw part of the match, but what I saw was good! As a friend
put it, Kata was on fire.
Re: US open!
She just has too much strengths to expose Kirilenko in a tough situation. She has net skills, forehand & the serve, what could hurt Kirilenko. Too bad though, Kirilenko is one of my favourites too :(
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Sku # 0131242100076
Bullhead comes with a boot cut fit for these men's denim jeans found at PacSun. The Boot Olive Jeans have a dark blue wash and a traditional five pocket design.
- Dark blue denim jeans
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Budget Management
Effective Budget Management at Valdosta State University involves all units of the university. The Budget Services office assists units with the effective use of financial resources to accomplish the mission of the unit and the mission of the University. Budget management requires open communication, review, and accountability at all levels of the university.
At the beginning of the fiscal year the President and Vice Presidents designate a Budget Manager for each budget in the university. The Department Head is typically the Budget Manager and the critical point for budget management. The Budget Manager could also be a Director, Coordinator, Program Manager, or Project Investigator depending on the nature and size of the unit as well as the source of the funds.
Register for Budgeting and Financials 101
This hands-on training is designed for budget managers and their assistants. It will focus on the following:
Upcoming Classes
|Valdosta State University Budget Process
Resources for Budget Management
Procedures Governing the Creation and Maintenance of University Departmental Budgets
Any Vice President may request the establishment of a new departmental budget through by emailing Antolina Pilgrim, Director of Accounting and Procurement email@example.com. A departmental budget manager must be designated for each new budget. This departmental budget manager is critical to the internal budgeting processes of the department. It is his or her signature alone which will be required to manipulate funds within the departmental budget or to authorize expenditures from its accounts, and it is this manager who will be expected to regularly review the departmental budgets and keep members of the department informed.
Routine or clerical tasks associated with budgeting or strategic planning may be given to others under the departmental budget manager's supervision; however, ultimate responsibility for the budget and planning for the department will remain with the named budget manager.
Should a departmental budget manager be unable to sign a document (vacation, etc), please notify Financial Services in advance via email Antolina Pilgrim, Director of Accounting and Procurement email@example.com. of the change in temporary signature authority. Any individual signing for a departmental budget manager should sign as follows:
Jane Departmental Budget Manager by Joe Temporary Signature Authority
Suggested Elements of Regular Budget Review:
- At the beginning of the fiscal year establish an annual plan for the department's activities and estimate what resources and scheduling will be required to accomplish their plans. One tool for the Budget Manager to use is the Department Budget Tracking Worksheet included with Resources below.
- Review monthly reports, report discrepancies and make amendments
- Communicate with department members regarding budget priorities and progress
- Communicate with Dean and/or Vice President to keep them current regarding the changes in needs and the impact for the school's or division's goals
- Meet year-end deadlines for purchases, etc.


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DAY 5 and 6 finds me enjoying the process and letting go of perfection.
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Saturday, May 18, 2013
I was sidelined by mental health, and spent the last day in bed asleep. there is always the aftermath of mania. I feel bad about it, am behind at work, but am learning to listen to my body and my body told me to sleep. I could get very discouraged at day 6, finding that my kids wont eat the dinners, and have eaten most of the snack foods. There is no money to grocery shop until next Saturday so I am going to have to go off the scheduled plan. But I am not going to use this an excuse to go all off plan, I am going to make a menu and focus on staying in my calorie range with the food that I have on hand, and continue to do the work outs. At some point today, after I do the dishes and have lunch, I am going to go to the gym and do extra long cardio and a round of strength training. The lesson here is that it's about the long term process, not the instant perfection. When I look at it like that; it's been a really good week. I've stayed in calorie range all but one day, and I have gone to the gym all but two days. I'm learning that I can make healthy choices, and that the process that I started in September 2011 will continue. I have obstacles, but I can make good choices in the short term that will pay off in the long term.
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Good for your attitude and insight in the end. I know
! Each of us are human so having a day where you eat what you want or do not go to the gym is okay! Those days allow us from binge eating and going back at our exercise even stronger!
Take it
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Listening to your body is the best thing you can do for it. I understand not being able to go shopping right away and improvising. Plan your next shopping trip before you go and stick to the list and what's on sale and you can stretch that dollar to be healthy. Keep on doing at least one thing for you each day, your you time is necessary to be a great mom!
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Hellgirl by RandyGreen by VPizarro626Watch
©2012-2016 VPizarro626
Love this, I would love to cosplay it.
Please let me know next time when you are going to color my inks so that I can add your information to my inks right away. Great job on the colors and enjoyed the style that you used with the colors.
I love how you stuck to the relatively flat kind of colouring that is so typical to hellboy without it looking actually flat. Great work!
Great work!
Great piece all the way around!
Love that it's in Mike Migola's style as well. Very awesome
Love that it's in Mike Migola's style as well. Very awesome
Nice work!
*rawr* what a Foxy lady... oh how I have missed looking at your work
looking good man


text:
ABC reports the Communications, Electrical and Plumbing Union, which represents Tasmania's Aurora Energy workers, is accusing the company of not protecting the privacy of employees who drive vehicles equipped with tracking devices. "That information now is out there for the general public to have a look at," said the union's Todd Lambert. "They can just download this app; they can punch in the password, which is very readily available across Aurora because so many people have it, and they can view people coming and going." A company spokesman indicated Aurora "has no intention of interfering with employee privacy," the report states.
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United States Department of Defense News
DoD Base Realignment and Closure 2005
Department of Defense Base Realignment and Closure 2005 with BRAC related documents, links, and other information.
Defense Technical Information Center
Online information for the Defense Community providing essential, technical research, development, testing and evaluation (RDT&E) information.
ODUSD Installations and Environment
Office of the Deputy Under Secretary of Defense Installations and Environment providing installation assets and services necessary to support our military forces in a cost effective, safe, sustainable, and environmentally sound manner.
USD Personnel & Readiness
The Under Secretary of Defense Personnel & Readiness is the principal staff assistant and adviser to the Secretary and Deputy Secretary of Defense for Total Force Management as it relates to readiness; National Guard and Reserve component affairs; health affairs; training; and personnel requirements and management, including equal opportunity, morale, welfare, recreation, and quality of life matters.
DoD Civilian Personnel Management Service
Department of Defense Civilian Personnel Management Service (CPMS) is the official web site for information about civilian personnel programs, systems, policies, and guidance at the Department of Defense.
This site is Section 508 compliant | Accessibility/Section 508 | Security Notice | Privacy Policy
©2016 The Office Of Economic Adjustment
Last Update: March 6, 2014


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text:
Avenue Bank offers business and personal banking services through a team of professionals dedicated to serving the creative spirit of Nashville. "The difference is real" is not just a catchy tagline, it is our commitment and promise to our clients.
A comprehensive range of services are available to meet your needs: checking, savings, CDs, loans, home equity loans and lines of credit, and mortgages. An Avenue Banker can help you select the solution that best suits your needs.
From entrepreneurs and small businesses to large corporations, Avenue's comprehensive range of services can meet virtually any need.
Being successful in life often leaves little time for managing your personal financial needs.
As a bank committed to the creative spirit of our city, Nashville's music and entertainment industry plays a key role in our business plan and has been instrumental in our success.
When your finances are managed with an exceptional level of service and expertise, you can spend more time focused on your business.
Buying a house is one of the most important investments you will ever make. That's why at Avenue Bank we have a variety of mortgage programs to best suit your needs as a homebuyer.
Tips, news and other resources to simplify your life and keep you abreast of current financial topics.
From songwriters and artists to entertainment management firms and publishing companies, our private client bankers have industry expertise in serving all aspects of the music and entertainment industries. Meet our private client bankers who can meet the needs of individuals, families and businesses in the industry with the embodiment of Nashville's creative spirit.
Ellen May has joined the Avenue Bank Team as a Vice President, Mortgage Loan Originator and Senior Relationship Manager in the Music and Entertainment Private Banking division. She has more than 25 years of experience in mortgage banking and has been recognized by the Nashville Mortgage Bankers Association as a top producer for several years. Ellen has spent the past 14 years originating in the Music and Sports / Entertainment Division. She is well-known throughout the music industry by most of the business managers of the stars as the go-to originator for mortgage loans.
Ellen is an active member of the Tennessee Mortgage Bankers Association, CMA, ACM, recording academy and involved in various volunteer efforts with her church. In her free time, she enjoys cooking, sewing, entertaining family and friends and collecting antiques! She and her husband, Jeff reside in Davidson county and have one son, Greg.
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Avenue Bank is open 24/7 when you access your account safely and securely through Online Banking. View balances, pay bills, transfer funds, and verify transactions with one secure login.read more


text: work West Virginia's Coal Miners And Their Battle For Freedom By Joe Donahue • Mar 12, 2015 Listen Listening... / 11:18 James Green is a celebrated labor historian and author of the book Death in the Haymarket. His new book is The Devil is Here in These Hills, a chronicle of West Virginia's coal miners and their fight for unionization and civil rights. The book is particularly relevant today as the arduous battle for the rights of West Virginia miners rages on. 'Getting Schooled: The Reeducation Of An American Teacher' By Joe Donahue • Oct 15, 2014 Listen Listening... / 14:41 Perhaps no profession is so constantly discussed, regulated, and maligned by non-practitioners as teaching. The voices of the teachers themselves are conspicuously missing. Defying this trend, teacher and writer Garret Keizer takes us to school in his book, Getting Schooled: The Reeducation of an American Teacher, an arresting account of his return to the same rural Vermont high school where he taught fourteen years ago. 8/29/14 Panel By Ray Graf • Aug 29, 2014 Listen Listening... / 38:50 Today's panelists are WAMC's Alan Chartock, University at Albany Journalism Professor and Investigative Reporter, Rosemary Armao, and political consultant Libby Post. Topics include:Ukraine UpdatePresident Obama on SyriaHackers, Russian and otherwise24/7 Email Ideas Matter: Connecticut Humanities Council and Work By Joe Donahue • Jul 12, 2013 Listen Listening... / 12:12 We are very happy to continue our new regular feature on the RT, entitled – Ides Matter: Checking in with the Public Humanities. It is our chance to check in with the Humanities Councils throughout our 7-State area to discuss important ideas and why they do indeed matter. This morning we spotlight Connecticut at Work. The yearlong programming initiative explore a changing workplace, changing culture of work, changing workforce. Stuart Parnes – Executive Director of The Connecticut Humanities Council joins us this morning. Retirement on the Line By Joe Donahue • Apr 24, 2012 We welcome Caitrin Lynch and speak with her about her book, Retirement on the Line: Age, Work, and Value in an American Factory .


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An ambitious plan for redeveloping and updating a stretch of Welton Street in Denver's Five Points neighborhood is probably years from becoming reality because of the sputtering economy and extreme caution among property owners.
Graffiti covers many of the shuttered buildings along the street, and even some occupied small businesses are in disrepair. Nonetheless, there are early signs of improvement.
The city's Office of Economic Development has targeted the Welton corridor between 20th and 30th streets as a pilot area for its Neighborhood Marketplace Initiative program. As such, it's assessing the neighborhood and talking to residents about the goods and services they want. Its report is expected to be presented to the community this fall.
"We're in a tough economic time, and it's been an area of focus in the past," said Andre Pettigrew, manager of the Office of Economic Development. "There are probably members of the community who have been frustrated by the fits and starts, but this is one of our high-potential areas. As you kind of look around at the investments that are being made and that have been made, it's moving in a positive direction."
That includes improvements Renee Cousins has made recently to properties she inherited from her father, Charles Cousins, who died in May.
Many of the properties, including at least 11 in the targeted corridor, had fallen into extreme disrepair.
Cousins, a pediatrician, said she won't make any major decisions about what to do with the properties for at least a year.
"I'm trying to familiarize myself with the plans for the area and with the properties," she said. "I am trying to make needed improvements and repairs. I'm not going to just let things deteriorate."
Among the buildings Cousins is improving is the old Simpson Hotel at 28th and Welton streets, which the American Legion will move into soon.
"Getting that building ready has taken more time and money than I imagined," Cousins said. "This is the pediatrician trying to figure out how to fix it up."
Laverne Bowman has been renovating another Cousins building at 725 E. 26th Ave., where she plans to open the bar Encores on 26th.
Other investors have been active in the neighborhood over the past few years as well.
Carl Bourgeois is planning to redevelop the historic Rossonian Hotel at 26th and Welton streets with an upscale restaurant and entertainment venue. He's also talking with the property owner to the south of the building about a mixed-use development on the site.
He said he expects construction to start this year.
"We're doing a substantial reconstruction of the interior and preserving the historic facade," he said.
A few years ago, an investment group that includes radio personality Tom Martino and real estate broker Chuck Wahlen assembled all the property on the east side of Welton from 21st Street to 23rd Street.
Zoning for the properties would allow a mixed-use project that could be at least 25 stories tall, Wahlen said.
At one point, the group had a buyer for the block between 21st and 22nd streets, but when the market tanked, the buyer walked away, Wahlen said. When the market recovers, the group either will sell the property or develop it themselves.
"To be under one ownership is a very good thing," Wahlen said. "It could be well-structured and well-planned."
Developer Brent Snyder controls a half-block on Welton between 23rd and 24th streets.
"Up until recently, we had planned to do a 100-unit, seven-story condo building on part of that site, but we couldn't get them presold so we couldn't get financing," he said. "Sometimes the best deals you do are the ones you don't."
Considered by some as the "Harlem of the West," Five Points was the first predominantly African-American neighborhood in Denver.
The neighborhood now includes the Black American West Museum and Heritage Center and Blair-Caldwell African American Research Library.
Multiple African-American businesses and churches are still concentrated in the community, and some in the neighborhood are concerned the new development will change the character of the neighborhood and leave its residents without some of the support services they've come to depend on.
"What I'm concerned with is that in the quest to go forward under the umbrella of urban renewal that we're not addressing the needs of all people," said Karen Brown-Gerdine, treasurer and past president of the Five Points Historic Association.
She's also concerned that as more redevelopment occurs, property values will rise to the point that residents will be pushed out of the neighborhood.
The city's Pettigrew is aware of the community's concern over gentrification of the neighborhood and is working to mitigate it by focusing on affordable housing and job creation and training.
"If retail sales go up, commercial rents go up and property values go up, we're successful," Pettigrew said. "But there is a level of risk in terms of displacement."
The city also recognizes the importance of preserving the history of the neighborhood, even as it works to improve it, Pettigrew said.
"We want to make sure we use that history and heritage to create a contemporary economic development opportunity," he said. "It's not about hanging onto the past; it's more about using it as a stimulus."
Margaret Jackson: 303-954-1473 or email@example.com
Charles Cousins
Born: Jan. 1, 1918. Died: May 4, 2009
Graduated: Manual High School
Business: Opened 715 Bar in Five Points, operated a cookie franchise at Westminster Mall, managed vending machines and a carwash.
Property: Holdings included at least 11 properties in Five Points, a mix of apartments and retail space. He rented the properties out to low-income people and had a reputation for forgiving rent payments when people couldn't pay.


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Home > News > World News
African Nations Cup moved out of Libya
Posted on Aug 24 2014 | IANS
Tripoli, Aug 24 : The Confederation of African Football has announced that Libya is no longer the host of the 2017 African Nations Cup due to security concerns.
"AFCON 2017 was moved out of Libya. CAF invites member associations to apply to organise and host AFCON," Xinhua quoted a CAF announcement as saying Saturday.
Libya was chosen as the host of the Africa Cup of Nations in 2017. However, poor security conditions made it impossible for the northern African country to host the tournament.
Libya's government had hoped the hosting of the Nations Cup would allow it to demonstrate that life has gone back to normal and encourage potential investors.
But since the 2011 turmoil, which toppled its former leader Muammar Gaddafi, Libya has witnessed an escalation in violence.
The recent deadly clashes between rival armed factions in major cities, including Tripoli, Benghazi, Gharyan, Zawiya, have raised fears that the conflict could turn into a full-fledged civil war.


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For a first time traveler, What are some nice places/countries to visit? I'm American. I want to travel some in 2014.
So you wanna travel outside of the USA? I have only been to Ireland, and it was several years ago. It was one of the most exciting, and awesome experiences I have had so far in my life. It was so green, and beautiful. I really want to go back, now that I actually have the ability to sleep anywhere, anytime. Then I can catch up on sleep from jet lag faster. I really love Ireland though. So I'd say go to Ireland.
Yeah, I've only travelled to Ireland (outside of the USA). And it was so green everywhere and really awesome. And just a lot of fun. If you ever go there, go to Dublin University and see the book of kells. It's like pre-bible sort of lol.
That's awesome! If I had the money, and time, I would totally do it too! :)
Sydney Australia
If this is your first time I would stick to English speaking places closer to home. Rather than go abroad, what about different states? A road trip would be simple to organise and you wouldn't need a passport.
Anywhere in europe
Go to the UK.
"See America first." Used to be an ad on TV ?
Have you seen the monuments in DC yet ? Each state is like a different country.
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Daily Doodle 2013.10.07 WitchHut by M0nkeyBreadWatch
©2013-2016 M0nkeyBread
30 miinute speedy
30 min?!! OMG!! I can only dream about that speed))
Thanks! The important thing isn't the speed but the fundamentals. Speed just comes after a lot of painting. So just keep painting and eventually you will become fast.
Ohhh, this is so creepy! The atmosphere's fantastic, I kinda want to jump in and explore.
Lookin' great! I love the composition, colors, and the slight hint of orange in the cave thingy


text:
Lussino Ice Cream Machine
With a capacity of approximately 1½ quarts, the 100-watt (.1 HP) Lussino produces up to 3 quarts within an hour. A built-in timer simplifies the operation and helps to ensure success. The machine's heavy-gauge stainless-steel blade, housing and bowl will provide years of trouble free service.
The blade and cover remove for easy cleaning; the bowl cleans with hot water and a damp sponge. Measures 12" by 18" by 11" tall. Includes instructions and recipe booklet. Made in Italy.
Features Hide
- Material:Stainless steel
- Dimensions: 12"D x 11"H x 18"W
- Capacity: 1½ quarts
- Included with Item: Recipes
- Model: 4080 DROP
- Made in Italy
Customer Reviews
Questions & Answers


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by C Chapman
from RCM&E
October 1971
45in span
Tags: Glider R/C
all formers complete :)
Sigma glider - RC slope soarer. Quote from article intro: - "Your free full-size plan for a 45in span R/C glider that packs away into a handy carrying case. By C Chapman. Sigma arose out of a need for a really transportable slope soarer, which could be taken anywhere without being a nuisance and without risk of being damaged. It travels in a padded suitcase only 2ft by 8in by 3.5in with all requirements except the transmitter." Direct submission to Outerzone.
Did I get something wrong with this plan? That happens a lot. Help me make a correction
* Credit field
The Credit field in the Outerzone database is designed to recognise and credit the hard work done in scanning and digitally cleaning these vintage and old timer model aircraft plans to get them into a usable format. Currently, and confusingly, it is also used to credit people simply for uploading the plan to a forum on the internet. Which is not quite the same thing. This will change soon. Probably.
This model plan (like all plans on Outerzone) is supposedly scaled correctly and supposedly will print out nicely at the right size. But that doesn't always happen. If you are about to start building a model plane using this free plan, you are strongly advised to check the scaling very, very carefully before cutting any balsa wood.


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Available formats: epub mobi pdf rtf lrf pdb txt html
I, William Buckel, am a writer of Fiction and Fantasy. I'm an ongoing student of history having written several historical novels. I live with my dog, north of Toronto, Ontario, Canada.
Review by:
Darlene Tabor
on March 29, 2013 :
(no rating)
enjoyed the book
(reviewed within a month of purchase)