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Chooglin' tour diary, Vol. 1
Written by Zach Zins of Chooglin'
Arriving in Paris
Tours begin in a haze. There are the stresses of planning, packing, and leaving work; there's the sadness of leaving your spouses, lovers, friends, and family behind; and all is cut with the excitement of seeing new places and playing for new faces. Sometimes the haze takes a more literal form, like a blizzard: 15 inches of snow that took longer to fall than forecasted was the haze that delayed our departure to Paris first from 3:30 to 4:00 p.m. last Monday afternoon, then another hour, then another hour, then yet another hour.
With nothing to do but read, wait, and visit the airport bar, the haze even took on a bit of a third, self-administered form by the time our flight was officially cancelled. We lugged our instruments and bags back to the light rail before dispersing to our homes and reconvening at the airport the following afternoon.
By then, every form of the haze had lifted, and we were just eager to get there. Fortunately, our first show wasn't until Thursday evening in Paris, so it was only our tourist time that was affected by the one-day delay. Despite the nearly 13 hours we spent in airports and in flight, the tumultuous form of non-sleep that happens on airplanes, and the seven-hour time change, we did our best to stave off fatigue and see the city. We were aided in that regard by our hotel furnishings, which could be politely described as spartan.
We took a stroll around the neighborhood, which was actually in a suburb just beyond the Paris city limits called Bagnolet. Insufficiently impressed, some of the seven of us went back to the hotel to sleep, but Hal, his beard, and I shuffled off into the bowels of the Metro to emerge minutes later at Pére Lachaise cemetery. It's a sprawling repository for the dead, but the above-ground graves, tombs, and sepulchers are crammed next to one another very tightly. The fog and the lack of any avian life outside of some loud, stern crows lent gravitas to the place.
Pére Lachaise Cemetery
From there, we rode the Metro a few more stops, walked several miles through the third arrondissement to the Notre Dame cathedral, watched a priest conduct mass and swing a mean censer to the accompaniment of medieval choral music, and took our pictures.
Notre Dame Cathedral
Priest conducting mass at Notre Dame Cathedral
The fog had turned to increasingly heavy drizzle, so were pretty soaked by the time we got back to the hotel.
Buoyed by a long, good sleep, Hal, his beard, and I hit the Eiffel Tower the next morning. Despite the tourist hordes and despite seeing it in photos too many times, it is still astounding in size and engineering. We walked back along the north side of the Seine for a while, but had to hop the Metro again to get back to the hotel in time to pack up for sound check. Upon our arrival, we ran into our van driver, Josef, a reserved guy from Prague, in the elevator. He must've sniffed out our 'Mericanness, because he asked straight away if we were from Chooglin'. We nodded, and everyone introduced themselves before heading to our first gig.
Point Ephemére was the club, though it could've been called 7th St. Entry East. It was a little bigger and had much taller ceilings, but had the same layout and grimy, black box interior. As we pulled up, three or four guys emerged and helped us haul in our gear. With seven guys in the band and plenty of practice, we're pretty efficient at unloading, but it was still nice to have help. After sound check, the band, the sound guys and sound lady, the promoter, and a few other people working at the club all went upstairs to a loft and had dinner. This is a pleasant difference from touring in the States where, if you're fed anything at all, it's often just a Totino's Party Pizza or something else equally as mediocre. In France, everyone who has anything to do with the show sits down at long tables and eats family style, starting with salad, charcuterie cuts, a cheese plate, sometimes a tuna salad or pasta salad, and red wine. Those alone would suffice, but since the French do not screw around with meals, it's followed by at least two hot courses and then dessert. And, of course, it's all prepared very well. This night's hot course was pork cutlets in a tomato-based sauce. We're eating like kings.
The show went well enough, though I suppose we had hoped for more attendees. It's tough to draw in the huge cities that have so many other things going on. We hung around for sometime afterwards with Juliette, who works for our booking agent; Louis and Celine, who did promotion for the show; and Justin, a fan from southern California who now lives in Paris. Louis eventually took us to another club, Le Plastique, where we drank beer, talked music, and swapped stories about Sweet Dog. Sweet Dog is the former drummer for our friends The Dexateens, a wild character, and a man who has achieved minor worldwide fame via his antics and relentless self-promotion. Everyone knows Sweet Dog; you probably do, too.
We are off to Lyon today.
Lyon and Evreux
The four-hour drive to Lyon didn't leave a lot of time for sightseeing, but we did manage to scramble to the main square before our next gig at Ninkasi Café. No city has the glamor of Paris, but Lyon was absolutely beautiful.
Fountain in Lyon
We also found a great record store with excellent R&B and garage rock collections. We were happy to find one of our records there, a record by our friends Wheels on Fire, and, best of all, an old copy of a Mighty Mofos record! Back at the club we again had help hauling our stuff and a post-sound check meal with all the courses. Veal in gravy was it tonight. Unlike the first show, there was an opening band this night, a good two-piece from Paris called Yeah Baby Yeah. They tore down, and we set up and began our set. This venue was decent sized--roughly akin to the Triple Rock--and it was packed to the gills, so the energy from the crowd smoothed over a couple of rough spots in our set that night. Great crowd!
Merchandise sales went well that night, but not as well as the beer, Jameson, and dancing to the DJ that followed. Watching Chooglin' shake their booties is hilarious and frightening. We're not terribly adroit.
Shawn Walker prepares for the demolition
The next morning, we had a five-hour drive back north to Evreux, a smaller city about an hour west of Paris. We had just enough time to walk from our hotel to the omnipresent Gothic cathedral. These places are amazing, and they are in every single town. The Catholics were packing fat stacks of cash from the Dark Ages right on through the Rennaissance, boy. We headed off to the club, l'Abordage. This place was tiny! But, like the first two venues we played, it was part of a multi-purpose space. The first two were combinations of restaurant, bar, and performance area (the first also had an art installation room, and the second actually had a microbrewery in it), but this building was more of a community center. Once again, a couple people came out to help us unload and set up for soundcheck. To fit us all on the stage required some creativity, but we managed, and then everyone went upstairs for a meal.
This one might have been the best yet. The first course was a spinach and greens salad with fava beans, corn, tomatoes, carrots, a mustard dressing, and a delicious garlic garnish that probably made my breath three feet long. My poor trombone later buckled in olfactory horror, I'm sure. The charcuterie and cheese plate followed, and the main course was creamy bits of ham over rice. Perhaps that doesn't sound appetizing, but it tasted great. The crowd was small, but we played our best set so far, and the attendees were really into it. Just like the Paris show, there were little kids in the audience with their parents, which is something you don't see in the States too often. It was pretty awesome to see the little urchins dancing around and headbanging--or, in the case of the little girl right up front, putting her fingers in her ears for the whole show despite wearing ear plugs. Ha! Lesson in humility.
Our next gig was in Lille, a good-sized city on the Belgian border, but we had to take the opportunity to stop in Versailles along the way and take a gander at the chateau. I had no comprehension of what I was about to see, but there are only three words to describe it: Ho. Lee. Shit! This is grandeur and opulence on an unimaginable scale. The chateau is unfathomably immense, and is surrounded by gardens on three sides that stretch literally to the horizon. I could go on for pages about the history of the place and the things we saw therein, but I'll spare you at least a bit of my logorrhea. If you ever get the chance, just go see it for yourself.
The Basilica at Versailles
A small part of the gardens at Versailles
The organ of the Cathedral of Saint Louis in Versailles
Lille and Bordeaux
The venue in Lille was called Cave a Musique. It was just a simple rectangular room, but the stage was big and the sound in the room was excellent. The crowd was decent sized and energetic once again. We shot the bull with some fans right after the set, including a little girl who was there with her parents and attending her first concert. She bought a Chooglin' shirt and made us sign it, which was about the cutest thing ever. We opened up for Citizen Fish, a ska punk group from Bath, England, that's been around for over twenty years and features a couple of the dudes from the Subhumans. Despite being a trombonist, ska is not my thing, but I gotta say these guys put on a hell of a show. A lot of corny Brit-skanking going on, but, man, they were energetic and had serious chops, especially the trombonist and bassist. Before and after our sets, they regaled us with many tales, including those of past shows they'd played at the Speedboat Gallery and the Triple Rock. Typical of Brits I've met, they had wit, turns of phrases, and crafty wordplay that had us slapping knees at a brisk clip. Funny dudes.
Instead of a hotel, we spent the night as guests of Candy, a punk rock gal who owns a piercing parlor, and her boyfriend, Nico, who plays standup bass in a psychobilly band called the Hellsonics. Their house is actually on the Belgian side of the border a couple miles from Lille. It's out in the sticks a bit, so that left plenty of time for jawing with Candy, Nico, and Schnaps (the promoter of our show), and playing with Candy's rescued dogs and cats. Schnaps told a story of a woman who years ago attempted to seduce him by speaking in Flemish. His imitation of Flemish made us laugh so hard that we never even found out whether the seduction was successful. Nico and Candy showed great hospitality: After Schnaps left, we were given free run of the TV and stereo system and supplied with a copy of the new Lemmy documentary, which we got some good laughs out of. Candy even made us bacon and eggs in the morning. Nice folks.
We didn't have a show the next day, but Schnaps wanted to interview us for the university radio station that evening. Our commotion loading into the van to go back into town for the interview must've pissed off the neighbor's monstrous goose, because this feathered lizard went apeshit, all charging and hissing at us. Good thing there was a fence between it and us, or else we might've been lining a goose nest somewhere in the next yard. It gave us a scare and a laugh. We wandered the center of Lille and the requisite Gothic cathedral beforehand, and found a brasserie that made a delicious but incredibly strong café au lait that damn near rendered me foaming at the mouth. We did the interview, and afterwards headed back to Candy's and Nico's for a second night. We watched some shitty German horror movie, some outtakes from the Lemmy documentary, and then hit the sack.
Clockwise from left: Jesse, Shawn, Schnaps, and Brian conduct an interview
We're off to Bordeaux this morning. Our van rides are, I would suspect, typical of most bands on tour: A lot of nodding off, a lot of noses in books and laptops, and surprisingly long periods of peace and quiet considering there are seven voluble mouths in the van. But there's plenty of conversing and joking around, too: Topics run the gamut from public policy to sports to women to bodily functions to music to literature and probably back to bodily functions again. Josef's iPod has been the van soundtrack so far. Fortunately, he's got pretty good taste in music. As I said earlier, he's reserved, but he packs a good verbal punch when he does talk. He's funny, his English is excellent, and he was a good sport in the green room in Lille when we put him under the Chooglin' inquisition lamp about life under communism in the old Czechoslovakia. Hal likes to sit up front with him and navigate, and with their long hair, mutual vegetarianism, and formidable beards, they've become fast comrades. At the merch table after our show in Lille, a French guy asked me who "those ZZ Top-looking motherfuckers" were. Well, monsieur, here 's who they are:
Josef, our driver, is on the left. On the right is Chooglin's bass trombonist, Hal "l'Oliphant Rouge" Longley
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ColorsonicaTwitter Stats
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un poco de admiración. un poco de desocupación
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Why don't you give it a try and compare Colorsonica to yourself ? Or if you are Colorsonica get even more feature rich & up-to-date stats with Premium & Pro Twitter Stats.
Twitter Counter is the #1 Twitter stats site powered by Twitter. It all started in June 12, 2008 and we grew rather rapidly because of our Twitter Counter badge. The button is a nice small image that shows your visitors how many followers you have on Twitter. Within a year the button was on many many blogs around the world and we displayed more than 100 million buttons in one month. We track follower stats for over 180 million users now.

subset: commoncrawl


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Parks Canada
Home > National Historic Sites > Fort Rodd Hill and Fisgard Lighthouse National Historic Sites of Canada > Partners
By working in collaboration with respected organisations that share our values, Parks Canada is able to better deliver its promise to Canadians by continuing to be a world leader in the protection and presentation of Canada's natural and cultural heritage. We believe in sharing leadership and working with our partners to offer unique, inspiring opportunities for Canadians to discover our treasured places and to achieve extraordinary results. We are proud to formally collaborate with the following local partners:
The Coast Collective is a local artists' collective and dynamic art centre that brings people together to celebrate the rich, cultural heritage of the Westshore communities of southern Vancouver Island. Recognising the ability of art to expand people's perception of place, history and land, Parks Canada and the Coast Collective have teamed up to present an annual artist-in-residence program at Fort Rodd Hill & Fisgard Lighthouse National Historic Sites. The program aims to enhance awareness of the cultural and natural spirit of the two national historic sites and to facilitate a connection to these national treasures through the process of creativity. During the summer months, artists from the Coast Collective undertake short-term residencies in which they use the grounds and facilities of the historic sites as their studio and their inspiration. In addition to producing works of art, each artist leads an interactive workshop with visitors using such media as printmaking, watercolours, pottery, music, oils, sculpture, Chinese brush painting and acrylics.
Science World at TELUS World of Science is a not-for-profit organisation that engages British Columbians in science and inspires future science and technology leadership throughout the province of British Columbia.
Parks Canada is excited to be collaborating with Science World in the delivery of our urban outreach program in Vancouver. Throughout the summer visitors to Science World at TELUS World of Science enjoy engaging stage shows, programs and activities that bring the stories of Canada's national parks, historic sites and marine conservation areas to the people of Vancouver.
The Vancouver Aquarium is a recognized leader in connecting people to the natural world. As a self-supporting, non-profit association, the aquarium is dedicated to effecting the conservation of aquatic life through display, communication, education and public programming, research and direct action. Nearly 40 million people have visited the Aquarium since its opening in 1956. Located in Stanley Park, we're open to visitors from around the world 365 days a year.
Parks Canada is excited to be collaborating with the Vancouver Aquarium in the delivery of our urban outreach program in Vancouver. Throughout the summer visitors to the Aquarium enjoy engaging stage shows, programs and activities that bring the stories of our national parks, national historic sites and national marine conservation areas into the heart of Vancouver.
The Royal BC Museum is located on Belleville Street at the border between beautiful downtown Victoria and historic James Bay, just steps from Victoria's Inner Harbour. The mission of the Royal BC Museum is to promote an understanding of the living landscapes and cultures of British Columbia and engage people in a dialogue about their future. Parks Canada is working collaboratively with the Royal BC Museum in the following areas:
The Beaty Biodiversity Museum opened on Vancouver's UBC campus in 2010 and works to inspire an understanding of biodiversity, its origins, and importance to humans through collections-based research, education and outreach. As Vancouver's natural history museum, BBM works to promote a greater sense of collective responsibility for the biodiversity of British Columbia, Canada, and the world.
Parks Canada is pleased to be collaborating with the Beaty Biodiversity Museum on a BioBlitz at Fort Rodd Hill National Historic Site. A BioBlitz is a fun 24-hour event in which teams of volunteer scientists, families, students, and other community members work together to find and identify as many different plants, animals, microbes, fungi, and other organisms as possible.


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P.S. It might be a silly question, I'm a FTM so am a bit over cautious I guess!
LO's outings- how often do u do it?
*On Edge? AlpacaXanax*
I live in NJ. Temps are in the low 40's/ 30's today. We go out almost everyday. I have 3 kids. The cold won't do anything to them as long as you keep them dressed warmly.
0 days snark free
pretty much every single day unless DH is watching her while i am at work on the weekend because he would rather be a homebody after working all week. we usually go to the gym every weekday, then we do a starbucks run. some days we go to baby and me storytime at the library, some days we go grocery shopping, some days we go fun shopping, some days we go to work at a client`s house (i`m an accountant), etc.
kayla (27) & kyle (27) - married 07/26/15.
mommy to emma grace (12/2011) and aaron titus (07/2013)
"I want to fart down her throat." Lil_Chrissy
I go to Walmart,grocery shopping or the mall once a week. I just put a hat , mittens and a fleece or hoodie on him for the car ride. I bring a blanket with me and just run I. With him. Lol
Jenn + Troy = DS 12/16/11 & TTC #2
Join me @ Mainstream Moms
A Canadian Mommy :-)
Jenn + Troy = DS 12/16/11 & TTC #2
Join me @ Mainstream Moms
A Canadian Mommy :-)


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Best sellers of peruvians in CA?
there are lots of ranches that sell peruvians in So. Cal.. Which are the best ones? and why? thanks
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Focused Practice. Instant Feedback. Documented Progress.
SmartMusic is the award winning software used by music educators around the world to enhance their programs and provides a way to dramatically improve their students' skills. Student practice is focused because they receive immediate feedback while listening to their performance and seeing the correct and incorrect rhythms and pitches onscreen. It also allows the teacher to provide students with the individual instruction and customized feedback needed to get better faster. Students are also able to hear their part in context with SmartMusic's professional background accompaniment, giving them a pitch and rhythmic reference when practicing at home.
SmartMusic is purchased as an annual subscription, which gives your student access to the largest digital sheet music library with accompaniment in the world. Subscribers sign up for classes designed by their teachers, and receive practice materials tailored to their specific needs. This allows students to receive the individualized instruction necessary to improve at a faster pace.
SmartMusic is available to band, string, and vocal students of all ages and skill levels, and is supported on iPad, PC, and Mac.
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Feb 2, 2016
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Little Tikes Dirt Diggers 2-in-1 Dump Truck
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Article Summary
What do you get if you cross a Raspberry Pi computer with an Arduino microcontroller? It might be an awful setup for a joke, but it's an enticing question if you're an electronics hobbyist or Internet of Things doer. Happily, thanks to Udoo, this is now a question with an answer. The mini PC combines the best of its predecessors in a compact PC-on-a-board with four times the power of a Raspberry Pi with all the functions of an Arduino Due microcontroller. The tinkerers of the internet have made short work of Udoo's Kickstarter target with 53 days remaining.
Read the full article: Udoo mini computer combines best of Arduino and Raspberry Pi
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Business professionals like you serve on the boards of hundreds of Boston-area nonprofit organizations, and many more boards are in need of your services. Business skills, enthusiasm and the desire to make a positive difference can have a huge impact on any nonprofit organization.
Get On Board, a one-day bootcamp led by Jim Grace and Liam Abramson, prepares business professionals like you for the rewarding experience of volunteerism, nonprofit leadership, and board participation. You'll learn about the different types and structures of boards, as well as the roles, responsibilities, and legal obligations of nonprofit board members. This bootcamp will also provide you with tools to find the organization that is a best fit for your skills and passions.
This fun and interactive seminar covers:
Who should attend:
Questions? email or call D'lynne Plummer, Director of Professional Development, firstname.lastname@example.com; 617.350.7600 x 7012
Participating Boston-area companies and institutions have included Bank of America, Boston College Carroll School of Management, Citizens Bank, State Street Corporation, Forrester Research, Fidelity Investments, The Boston Globe, Investors Bank and Trust Company, Tufts Health Plan, Staples, Goodwin Procter, Mintz Levin and many others.
Get On Board is part of our Business on Board program, which provides professional development training and resources for businesses and professionals, focusing on corporate citizenship and board development services for arts organizations. Whether you are looking to serve on a not-for-profit board or looking to use business skills in a volunteering capacity, our programs provide an opportunity to enhance leadership knowledge, creative thinking, group decision-making, and networking opportunities with people that share your interests. We work with not-for-profit organizations that are looking to expand their board with new members who have graduated from Business on Board training. We also offer consulting services for not for profit organizations looking to strengthen their organization through seminars, matching organizations with business volunteers, and training for board best practices.


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Appetizers are featured in today's column. A favorite for a large party, is a he-man stuffed French bread appetizer. It is especially good for any gathering — large or small. For a small gathering use a half loaf of French bread and a whole for the large party.
Stuffed French bread is quickly and easily assembled. To me, it's definitely reminiscent of pizza. It's the perfect answer for a party appetizer or coupled with a green salad it's a festive and enjoyable dinner.
To make stuffed French bread slice a loaf of French bread horizontally. To make the long length easier to handle, slice each half of the French bread into two sections. One loaf of French bread makes four parts. Hollow out the bread with your fingers leaving the crust and about a ¼ inch of bread remaining. Tear or cut the bread pieces hollowed into bite size chunks. Put the bread chunks into a large bowl.
This part of the recipe is where the creativity and fun begins. Add the amount and type of ingredients that you would normally have on a favorite pizza. I usually add 1 to 2 cups of each of the following: cheese (I use sharp Cheddar or Monterey jack), mushrooms, olives and onions. Then I add 2 to 4 cloves minced garlic, a small amount of fresh red pepper (if I have one on hand) for color and 1 small can diced green chilies, which adds superior flavor for a vegetarian style. To delight the meat eaters, add 2 cups cooked diced Italian sausage. Add more or less of these ingredients to your taste and, of course, feel free to add other favorite ingredients not included here.
Mix all the ingredients together and moisten with 1 egg and approximately ¼ cup mayonnaise, enough so that the bread-vegetable mixture is cohesive. With clean hands, scoop the stuffing mixture and gently mound it back into the hollowed French bread shells. Place the stuffed French bread on a cookie sheet and bake at 375 degrees for 15 minutes until the filling is hot and bubbly and the edges of the bread are toasted. Slice the stuffed French bread crosswise (as you would garlic bread) into individual slices and serve.
If you should end up with unused French bread, as sometimes happens to me, an excellent recipe for using left-over French bread is crostini.
What is crostini? Crostini is toasted bread, which you can top with a variety of savory spreads. Although a chicken liver spread is traditional, any favorite homemade or store-bought spread is delightful. Crostini can be made from any type of bread. However, the type of bread that is the tastiest is thinly sliced bread that is lightly brushed with olive oil before toasting.
Crostini — Preheat oven to 350 degrees. Slice good store-bought Italian or French bread into 1/4-inch slices. Place on a baking sheet and brush lightly with olive oil. Brushing the sliced bread with flavored oil will result in even tastier crostini. Bake the slices until the edges are golden and centers are crisp, about 10 minutes. One loaf of bread makes about 4 dozen crostini. Crostini topping should be spreadable.
Once, I made bite-size crostini sliced from herb breadsticks. They were the perfect accompaniment for a crab spread and being bite-size no one felt like they over ate the appetizer. Crostini can be made the day before to ease last-minute party jitters. However, don't assemble them with a spread more than a half-hour in advance or they might become soggy.


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Combo Discount:
Didn't upset my digestion
1 person found the following review helpful
Posted by Reviewer2255839 on Aug 02, 2013
I was interested to find that this flour did not upset my tummy like regular supermarket flour. It tasted great too.
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Note: iHerb does not imply any medical claims from this review. Disclaimer.


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- Industries
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Resources > Case Studies
Read about a few of the success stories top companies have had using Plum Voice to help automate phone calls or business processes.
KLC, one of the largest providers of afterschool care, relies on Plum for an IVR enabled time and task management solution for its mobile workforce.Read More >
Michigan Basic Property Insurance Association depends on Plum for IVR enabled customer service round the clock.Read More >
New York State's Department of Health relies on Plum VoiceXML IVR to deliver various types of real-time status inquiries to the state's healthcare community and to the general public.Read More >
PNY Technologies is a billion-dollar enterprise, distributing thousands of computer-related products including memory chips and graphics cards. The PNY call center relies on Plum turnkey systems for IVR solutions that are robust, reliable, easy-to-modify, and manageable.Read More >
Health Integrated is a leading provider of managed care services to insurance companies and state Medicare and Medicaid programs, for the States of Wisconsin, Georgia, Colorado, etc. Health Integrated handles case management for literally millions of claims monthly.Read More >
InMoment provides cutting edge market research -- accurately, affordably, and in real time. Their goal is to gather feedback on a consumer's experience for clients from the retail and service industries.Read More >
Museum411 delivers a new breed of museum audio tours through visitors' cell phones via interactive voice response applications based on the Plum VoiceXML platform.Read More >
American Tire Distributors (ATD), the largest distributor of tires, custom wheels, and shop supplies, set out to build a national campaign that would increase phone enquiries, web site visits, and store traffic. ATD relies on Plum Voice to help their customers connect to local dealers across the country.Read More >


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It looks like OBD2 to me, but I'm no expert.
ok I have a renault Laguna 2002, under the ashtray theres this plug
now does this look like a OBD-II ?
if so.. I'm after a bit of kit and software to enable me to display info on my screen.. any ideas ?
It looks like OBD2 to me, but I'm no expert.
im guessing so too, but a quick trip to te mechanics and youll get a deffinete answer.
It aint no family car.
SEE MK2 At : -
looks like it to me.
Car: 2000 Audi A4 Avant 1.8t
Carputer 2.0: removed. Back to stock.
Borrowed from autotap faq...
Your vehicle must have an OBD II connector that looks like this:
and has pin combinations representing one of the four OBD II protocols:
J1850 VPW – The connector will have metallic contacts in pins 2, 4, 5, and 16, but not 10.
ISO 9141-2 – The connector will have metallic contacts in pins 4, 5, 7, 15, and 16.
J1850 PWM – The connector will have metallic contacts in pins 2, 4, 5, 10, and 16.
KWP2000 (ISO142300) – The connector will have metallic contacts in pins 4, 5, 7, 15, and 16.
The pins are used in the following way:
Pin 2 - J1850 Bus+
Pin 4 - Chassis Ground
Pin 5 - Signal Ground
Pin 6 - CAN High (J-2284)
Pin 7 - ISO 9141-2 K Line and ISO/DIS 14230-4
Pin 10 - J1850 Bus
Pin 14 - CAN Low (J-2284)
Pin 15 - ISO 9141-2 L Line and ISO/DIS 14230-4
Pin 16 - Battery Power
If your connector has extra pins, don't worry. Manufacturers can use them as they see fit.
thanks fella.. looks good :-) just got to decide if autotap is worth $200, I mean the only benefit really is so I can show off to my m8's.. lol
No need to spend $200 when you can spend $99. Check out Digimoto.comOriginally Posted by CdRsKuLL
Digimoto enables you to do 0-60 & standing 1/4 times, as well as plot power & torque.
I ordered online, their Elmscan ISO interface, software & cables. Works fine on my Rover45TDi. Took just 5days to arrive and including £14 UK vat, cost £85 - you pay the vat when collecting it from your local Royal Mail sorting office.
Just check which protocol you need as they do offer interfaces for all 3.
You can download free software to use with the interface from:-
http://www.wgsoft.de (digital dashboard display)
Does the digimoto software update as fast as it shows in the flash demos? I've seen some other OBDII software and it updated slower than this.
I believe it depends on how many sensors you are looking at.


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The UP North Lodge in Gwinn is raising money for local organizations every Tuesday.
Bike Night started five years ago as an event centered around motorcyclists but has grown into a way for the lodge to give back to the community.
A number of local businesses and groups donate items that are auctioned off. The money for this Tuesday's Bike Night went to Big Brothers Big Sisters.
"It's a great feeling at the end of the night when we're able to give the agency a check and to know that you've been a part of that, a huge part of that, is a wonderful feeling," said Cheryl Wootton, owner of the UP North Lodge. "And knowing that agencies like Big Brothers Big Sisters and Cancer Care are going to benefit from your help."
Jumparooz also provided a bounce house and donated all of their profits to the organization. The business sponsor Tuesday was Crossroads and Kountry Korner Shell. Next Tuesday's Bike Night will raise money for Cancer Care.


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Download this free, 140-page Flexible Packaging Playbook jam-packed with strategies for success, best practices, and pitfalls to avoid. Learn more »
Article | August 31, 2003
Adhesives Research, Inc.
(Glen Rock PA) promoted Kären M. Olson (above) to president and CEO.
Pechiney Plastic Packaging (Chicago IL) promoted Julie Suski-Gartrell to product manager Food Flexible Packaging North America.
Beckhoff (Minneapolis MN) hired Graham Harris as president of Beckhoff Automation LLC.
Seal-It (Farmingdale NY) appointed Alan Wolk as vp of operations.
Alloyd (DeKalb IL) named Ron Leach as president and CEO. Edwin Parkinson was promoted to chairman.
Omron (Schaumburg IL) appointed Paul Witt as strategic sales manager.
Ranpak (Concord Township OH) hired Mark S. Kopaskie as general sales manager for the western region of the United States. Roderick V. Bone joined the company as the territory manager in Southern California. Also hired was John Salvemini as territory manager in the Northern New Jersey area.
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Henson brings on Base79 to optimize YouTube catalog
The Jim Henson Company has formed a partnership with Base79 that will see the Los Angeles-based digital video company help boost Henson's original content presence on YouTube.
Using its proprietary technology and experience as the largest international YouTube network, Base79 aims to grow the global audience for paid YouTube channel Jim Henson Family TV, which includes popular titles such as Pajanimals, Sid the Science Kid and Fraggle Rock.
The company will handle all rights management and ad sales of the content and will leverage its international foundations with offices in London, Sydney, Paris, Madrid, Berlin and its new L.A. office run by executive Ben Lister.
Base79, which has formed similar kid's entertainment partnerships with Zodiak Entertainment and Magic Light Pictures (The Gruffalo), is the largest YouTube partner outside North America and one of the leading partners in YouTube's original programming initiative.
It currently generates more than 800 million views per month across 1,500 YouTube channels.
Our spring edition of iKids Digital is now available! We're taking a look at the looming rise of VR in kids entertainment, how MCNs are boosting the marketing might of kidsnets, and the rise of artificial intelligence in kids tech toys.


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A former parking lot at the Huntington Library is now a beautiful Visitor Center, with more to come
Wednesday, January 21, 2015
Christina Przybilla.
On January 14, the Huntington Library in San Marino, California opened the doors to its newly constructed visitor center, designed by Architectural Resources Group (ARG) on the grounds of prestigious gardens' former parking lot. This first part of a larger 52,000 square foot project consists of an admissions area, a café, and a new museum shop.
Slideshow> Ellis Island West
Thursday, March 24, 2011
Sam Lubell.
When anyone thinks of U.S. immigration in the late 19th and early 20th centuries they picture Ellis Island. But the West Coast's counterpart was the US Immigration Station at Angel Island, a 1910 collection of modest timber buildings located off the coast of Tiburon, just outside San Francisco.
Until the end of World War II thousands of immigrants arrived here; most from the far east. And while Ellis Island was no picnic, this was an even harder place. Technically a detention center, its crowded barracks held hundreds of people for up to a year at a time. Thanks to California State Parks' recent $20 million renovation by SF-based Architectural Resources Group and Tom Eliot Fisch, you can now visit.
Advertise on The Architect's Newspaper.
East Coast
West Coast


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Cold War Reflections and Today's Realities
Experts recall how the the United States envisioned its role in a post-Soviet world two decades ago when the Berlin Wall fell and whether...
Interviewees: James M. Goldgeier, Whitney Shepardson Senior Fellow for Transatlantic Relations, Council on Foreign Relations
Derek H. Chollet, Senior Fellow, Center for a New American Security
Interviewer: Robert McMahon, Deputy Editor, CFR.org
June 12, 2008
The Clinton administration eventually coalesced around core principles featuring embrace of trade and globalization, democracy promotion, and the use of military force, the authors say. Opposition Republicans, meanwhile, splintered after the collapse of communism over how America's role in the world should be redefined. Goldgeier and Chollet say these are legacies that both presidential frontrunners are dealing with today as they seek to shore up supporters in their parties and prepare new administrations that would take office in January 2009. Their advice after chronicling rocky intra-party transitions in 1993 and 2001: start preparing now.
Terms of Use: I understand that I may access this audio and/or video file solely for my personal use. Any other use of the file and its content, including display, distribution, reproduction, or alteration in any form for any purpose, whether commercial, noncommercial, educational, or promotional, is expressly prohibited without the written permission of the copyright owner, the Council on Foreign Relations. For more information, write firstname.lastname@example.com.
In The Hacked World Order, CFR Senior Fellow Adam Segal shows how governments use the web to wage war and spy on, coerce, and damage each other. More
Red Team provides an in-depth investigation into the work of red teams, revealing the best practices, most common pitfalls, and most effective applications of these modern-day devil's advocates. More
Through insightful analysis and engaging graphics, How America Stacks Up explores how the United States can keep pace with global economic competition. More
India now matters to U.S. interests in virtually every dimension. This Independent Task Force report assesses the current situation in India and the U.S.-India relationship, and suggests a new model for partnership with a rising India.
Rates of heart disease, cancer, diabetes, and other noncommunicable diseases (NCDs) in low- and middle-income countries are increasing faster than in wealthier countries. The report outlines a plan for collective action on this growing epidemic.
This report asserts that elevating and prioritizing the U.S.-Canada-Mexico relationship offers the best opportunity for strengthening the United States and its place in the world.
Experts recall how the the United States envisioned its role in a post-Soviet world two decades ago when the Berlin Wall fell and whether...
The fall of the Berlin Wall 20 years ago marked a triumph of the U.S. strategy of containment. But U.S. policymakers have been struggling to...
The United States' current respite from geopolitical rivalry ought not to be wasted, writes Richard N. Haass.
Richard N. Haass argues that the United States should adopt a doctrine of Restoration as its guiding foreign policy framework, focusing on...


text:
Synonyms of bench in English:
2 in the centre of the laboratory was a huge bench
workbench, worktable, table, counter, trestle table, board, work surface, worktop, buffet
3 the bench began to hear the evidence
Definition of bench in:
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The teak pool chairs are Muffie's favorites, even though they're 12 years old. "I always recommend buying quality teak furniture, because you want something that will weather well and not split," she advises. A vintage bar cart can be wheeled out for poolside entertaining.
Source Guide
Pillow fabrics (on chaises): Ziggurat in Charcoal (174480) and Trellis Knot in Ivory and Onyx (174222); fschumacher.com.


text:
American English: /haɪˈpərtrəfi/ British English: /hʌɪˈpəːtrəfi/
Translation of hypertrophy in Spanish:
noun plural hypertrophiesuncountable or countable
- Example sentences
- Many risk factors for coronary artery disease also are predictors of hypertension, left ventricular hypertrophy, and diabetes mellitus.
- It leads to left ventricular hypertrophy and increased connective tissue content, both of which decrease cardiac compliance.
- Cardiac hypertrophy - the enlargement of the heart muscle cells - can be fatal.
Definition of hypertrophy in:
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text: Turn Left at the Cow by Lisa Bullard Thirteen-year-old Trav feels like a fish out of water in rural Minnesota in this funny mystery about a boy who discovers his dad may have been a bank robber. Format: Hardcover ISBN-13/ EAN: 9780544029002 ISBN-10: 0544029003 Pages: 304 Publication Date: 10/08/2013 Carton Quantity: 24 Grade Level: 5,6,7 Age Range: 10,11,12 Also available in: eBook - $6.99 Paperback - $6.99 About the Book About the Author Excerpts Reviews Thirteen-year-old Trav has always wondered about his dead-before-he-was-born dad. But when he heads from California to his grandmother's house in rural Minnesota, hoping to learn about his past, he gets more than he bargained for. It turns out his dad was involved in a bank robbery right before he mysteriously disappeared, and the loot from the take is still missing. Along with Kenny and Iz, the kids next door, Trav embarks on a search for the cash. But the trio's adventure quickly turns dangerous when it becomes clear that someone else is looking for the money—someone who won't give up without a fight! Subjects Love & Romance Law & Crime Mysteries & Detective Stories Humorous Stories Family/Stepfamilies Boys & Men Social Issues/Runaways Related Subjects Coming of Age Mysteries & Detective Stories Books for Boys Love & Romance Family Relationships Lisa Bullard Lisa Bullard, the author of many picture books and nonfiction titles for younger readers, makes her fiction debut with Turn Left at the Cow. She lives in Minneapolis, Minnesota. Visit her website at www.lisabullard.com. Read More Other Books By The Author Turn Left at the Cow Buy Now Chapter 1There were so many dead bodies stuffed into Gram's freezer chest that it was kind of like wandering through a cryonics lab. You know, one of those places where they turn rich old guys into Popsicles? Gram had been hearing odd noises from her cellar for a while now, and she was convinced it was this dying freezer she kept there. So my punishment for the day was to clean it out and stuff everything into these jack-o'-lantern leaf bags that Gram had been saving since who knows how many Halloweens ago. In grandma land, even the contents of the freezer were way different than what I was used to. Agreeing on what a freezer should hold seemed to be the only thing my new stepfather and I had in common. But here, instead of meeting up with my best buds Ben and Jerry, I was finding nemo and his friends, wrapped up in white packages with writing on the outside so you could clue into whichever member of the magical forest had taken a hit and when. I stuffed "Duck" and then "Venison" and "Walleye" into another one of the pumpkin bags. Man, those packages had been waiting to be set free longer than I had. Maybe the noises Gram had been hearing weren't from the freezer. Maybe they were from the ghosts of all these dead things, plotting up some serious revenge. By the time I reached the bottom of the frozen graveyard, Gram's cellar was feeling a lot like one of those the-killer-is-in-the-basement places, where the stupid kid always ends up kicking it in slasher movies. only one big ice-covered box was left. I bent over the side of the freezer chest and tugged at the corner of the box. Not enough leverage—the thing was iced in place as if it had been gorilla-glued. I hoisted my upper half deep into the chest and yanked again. No go. I leaned way over, hanging on to the edge of the freezer with one hand while I grabbed the box with the other. Then I got my Hulk on and gave one last mighty pull. That's when nemo and his friends finally took their revenge. Turned out the stupid box was heavier than I'd realized. I leaned too far and pulled too hard, and then the box broke free and I over-ended into the appliance of death. As I was falling in, something rolled out of the box into the bottom of the freezer. the last thought I had before I landed on it was that maybe I had some mutant form of jet lag or something. Because I could have sworn it looked exactly like a head. A frozen human head. "Family secrets, an unsolved bank robbery, summer on a lake, a treasure island and a first romance are the ingredients for this inviting middle-grade mystery. . . . A promising fiction debut." —Kirkus "Bullard has a good sense of family and community dynamic and articulates complex conflict and resolution with honesty and humor. . . . With a warm narrative, careful plotting, actual danger, and the beginnings of romance, this adventure has something for everyone."—Booklist "Through strong character development, Bullard is able to explore family dynamics in a way that is both relatable and informative. Fans of books like Sheila Turnage's Three Times Lucky are sure to enjoy this suspenseful and heartwarming novel."—School Library Journal You May Also Enjoy Raging Sea Michael Buckley Buy Now The Battle of the Vegetables Matthieu Sylvander Perceval Barrier Buy Now Assassin's Masque Sarah Zettel Buy Now


text:
The Rally for a Future initiative, supported by actor Liam Neeson, is organised by union members working in the JTI-Gallaher and Michelin factories in Ballymena.
UUJ's Jackson Mc Greevy and CIT's Noel McNamara in action during the Fitzgibbon Cup Round 2 match.
A horse forages for grass in the snow on the hilltops between Glossop and Buxton.
The Royal Mint of Myla Xia has released a coin featuring the playful figure of a monkey to celebrate the forthcoming Chinese New Year.


text:
Stop in today to check out our HUGE selection!
With over 500 domestic and import beers in stock, you're sure to find what you're looking for.
Enjoy freshly poured beer from the comfort of your home. We have a 10-tap growler station for you.
Whether you're hosting a big event or small gathering, we'll provide you with the perfect selection.


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Previous Episode | Next Episode
Minna Hajimete Bakari De Ojaru
English Title: Everything Is New Here!Minna Hajimete Bakari De Ojaru (Everything Is New Here! , Everyone's Just Beginning) (1998) Season 1 Episode 103- Ojarumaru Anime Episode Guide by Dave Koch
This page has been viewed 7 times this month, and 313 times total.
- Ojarumaru AnimeAnime Episode GuideEpisode GuideTelevisionSeriesCartoon
- Traditional Animation
- NHK, Adobe Pictures, Nippon Crown
- Animation Studio: Studio Gallop
- Distributed by: Enoki Films USA, Inc.
- Cartoon Characters: Ojaru (Prince Mackaroo), Kazuma (Cozmo), Scarlett, Khakie, Blue-Joe, Tommy, Marie, Lord Uppland, Lady Uppland, Cyber-Fly, Princess Camellia.
- Voice Actors: Hiroko Konishi.
- Directed By Akitaro Daichi.
- Produced By Atsuya Hirooka, Masakazu Shioura.
- Written By Takashi Yamada, Aki Itami, Fumiyo Sakai, Mamiko Ikeda, Masahiro Yokotani, Miharu Hirami, Yoshiki Sakurai, Yuka Yamada, Yukinori Fukujima; more Writers ...
- Music: Harukichi Yamamoto.
- Editor: Hisano Uchino.
- First Aired on October 07, 1998.
- Originally Aired on NHK-E (Japan).
- Running Time: 10 minutes.
- Episode Number: 103
- Season: 1
- Color
- Japan
Cartoon Summary:
After Mackaroo spends a night at Cozmo's house, Cyber-fly comes over. Mackaroo surprises Cozmo's parents at breakfast with his aristocratic comments. The three scamps, disguised as deliverers, show up to get back the demon... (more)
Cartoon Production Information:
This TV series ran for 1430 episodes; another episodes are to be produced.
A 30-minute theatrical film based on the series for young children, "Summer of Promises," was released in 2000, introducing the character of Semira.
Cartoon Video:
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text:
Tags: katsumi, virgin, screen, sure, hot, asian, girl, knows, two, cocks, same, time, porn stars
Pornstars: Krisztina Bella
Submited: 6 years old
Views: 3963
Copyright © 2006 - 2016 DeviantClip.com - All Rights Reserved.
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Section 2257
Katsumi is not a virgin of the screen that's for sure, so the hot Asian girl knows how to take two cocks at the same time!


text:
Osteoarthritis hip - grading
Dr Henry Knipe ◉ and Dr Paresh K Desai et al.
Osteoarthritis of the hip can be graded according to severity on imaging.
Conventional radiograph grading
- grade 0: normal
- grade 1: possible joint space narrowing and subtle osteophytes
- grade 2: definite joint space narrowing, defined osteophytes and some sclerosis, especially in acetabular region
- grade 3: marked joint space narrowing, small osteophytes, some sclerosis and cyst formation and deformity of femoral head and acetabulum
- grade 4: gross loss of joint space with above features plus large osteophytes and increased deformity of the femoral head and acetabulum
MRI grading
- grade 0: normal
- grade 1: inhomogeneous high signal intensity in cartilage (T2WI)
- grade 2: inhomogeneity with areas of high signal intensity in articular cartilage (T2WI); indistinct trabaculae or signal intensity loss in femoral head & neck (T1WI)
- grade 3: criteria of Stage 1 & 2 plus indistinct zone between femoral head & acetabulum; subchondral signal loss due to bone sclerosis
- grade 4 above criteria plus femoral head deformity
Related articles
- autoimmune
- seronegative spondyloarthritides
- Jaccoud arthropathy
- juvenile idiopathic arthritis
- lyme arthritis
- rheumatoid arthritis
- systemic lupus erythematosus
- degenerative
- erosive osteoarthritis
- osteoarthritis (mnemonic)
- primary cystic arthrosis of the hip
- rapidly destructive osteoarthritis of the hip
- secondary synovial osteochondromatosis
- depositional
- infectious
- miscellaneous disorders
- related articles
- 1. Li KC, Higgs J, Aisen AM et-al. MRI in osteoarthritis of the hip: gradations of severity. Magn Reson Imaging. 6 (3): 229-36. - Pubmed citation
- 2. "Atlas of standard radiographs of arthritis" Unesco and WHO PDF
Synonyms & Alternative Spellings
|Synonyms or Alternative Spelling
|Include in Listings?
|Osteoarthritis Hip - Staging
|Osteoarthritis hip - grading


text:
Watch Geburtig (2002) online free
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Geburtig: Geburtig : The terror of the holocaust proves itself to be a lasting force, even between generations, in this film about the lasting effect of this event. A man named Geburtig is the only person alive who can testify against a Nazi war criminal set to go on trial. A reporter named Susanne leaves her boyfriend, Danny, in search of the aged man and finds him, only to develop feelings for him that are beyond professional interest.
4.0/10 (2 votes)
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text:
Commission by SpazzyKoneko 7 by NapalmKrillosWatch
©2011-2016 NapalmKrillos
Ah, it sweet
Indeed. ^^
Man, Goldmane is awesome and confused that Lassie tried to go closer.
Yeah, it's adorable~
That's cute x3
Aw. :3
Well done by the artist.
Sweet and so cute. ^w^
Hope Michael Sanchez doesn't sees this xD
hehe Brandy likes to do that with people she realy likes too. SpazzyKoneko did a great job here.


text:
FUJI ELECTRIC 7MBR50SB-120-50 IGBT Array & Module Transistor, Semitrans, N Channel, 75 A, 2.1 V, 360 W, 1.2 kV, Module
Image is for illustrative purposes only. Please refer to product description.
- Manufacturer: FUJI ELECTRIC
- Newark Part No.: 56P5525
- Manufacturer Part No 7MBR50SB-120-50
Product Specifications, Documents & More
- Collector Emitter Voltage V(br)ceo: 1.2kV
- Collector Emitter Voltage Vces: 2.1V
- DC Collector Current: 75A
- No. of Pins: 24
- Operating Temperature Max: 150°C
- Power Dissipation Pd: 360W
- SVHC: To Be Advised
- Transistor Case Style: Module
- Transistor Polarity: N Channel
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posted by Manita Dosanjh | 0 Comments
The restaurants of Dublin are waiting for you to visit, so come and say hello! You don't have to have deep pockets for a great meal, Dublin is kind to the thrifty and when it comes to food, even the most modest funds will find you something amazing. You can work your way through dozens of different cuisines and have plenty of room left in your budget for a relaxing pint of Guinness - all against the backdrop of the capital's cosy charm.
Bits and Pizzas
Cuisine: Italian
Average Spend: Lunch Main approx. €9, dinner mains approx. €13
Simple, humble pizza is the game at Bits and Pizzas. Whilst there are other Italian dishes on the menu, it's the pizza they're known for, and with both vegetarian, gluten free and low-calorie options, there's something for everyone. The chefs are often trying innovative ideas – sweet chilli prawn is a recent venture – but the traditional toppings are always available, and always good. They even do deliveries…
15 Patrick Street, Dun Laoghaire, Dublin
Greedy Goose
Cuisine: Varied
Average Spend: Lunch mains approx. €9, dinner mains approx. €9
The clue's in the name…from chana masala to surf n turf, the Greedy Goose serves it all. A great way to take advantage of the extensive menu is to opt for the 'Early Bird' set menu – for just under €25 you can get four savoury dishes from each section – perfect for sharing. The restaurant has had some rave reviews across the web and the service is fast. What are you waiting for?
15 Townyard Lane, Malahide, Dublin
Bewley's Grafton Street Café
Cuisine: British
Average Spend: Lunch mains approx. €9, dinner mains approx. €13
From Humble beginnings as a tea room in 1835, Bewley's is a family run business that has blossomed over the years into one of Dublin's most charming cafés. Today, you can find everything from pizza to tiramisu on the menu, freshly made and served against a stunning backdrop of marble and stained glass. Bewley's also promises some of the best coffee in Ireland –they won the title of 'Best Tourist Venue' this year.
Northern Cross, Malahide Road, Dublin
Cuisine: Wholefood
Average Spend: Lunch mains approx. €9, dinner mains approx. €11
'Passionate about tasty food, vegetarianism and veganism' – if that sounds like your thing then you won't want to miss a trip to Cornucopia. Wholefood is often expensive, but in the true spirit of Dublin charm, Cornucopia has made local organic produce affordable, so you can eat vegan and still have euros left for some cheeky Irish drinking. The multi-award winning restaurant is so popular that they even have their own cookbook, Cornucopia At Home.
19/20 Wicklow St, Dublin 2
Cuisine: Mexican
Average Spend: Lunch mains approx. €8 Dinner mains approx. €14
Do you prefer your cheap eats with a little bit of extra heat? Acapulco is the perfect place for those who like to spice it up. They have all of the Mexican staples – scrumptious fajitas, home-made nachos and gluten free tacos – and you can finish it all up with an authentic Mexican deep-fried ice cream…mmmm. Acapulco also boasts a 100 year old margarita recipe made with pure agave tequila. Doesn't get much better if you ask me.
7 South Great Georges Street, Dublin
Anthony sherlock said
" A fascinting blog, well written. Wish I could visit some of the places mentioned...
Cassandra C said
" Ha Long Bay, Vietnam! I went skinny dipping at night there, and there were l...
Alex Tyner said
Ram said
" Beautiful places i loved it find out some interesting places in the Himalayas
Josh Freeman said


text:
Hanging at the Gundam Hotel by VampBeautyWatch
©2013-2016 VampBeauty
I was lucky enough to stay and have a shoot inside the Gundam Hotel in Japan. Definitely was a dream of mine.
Photography by Long Vo
Photo is available in my store on my website below ^_^
Photography by Long Vo
Photo is available in my store on my website below ^_^
You are to fine
Love mecha. That must have been super cool. Definitely on my list of things to visit in Japan =^^=
Sooo jealous. Want to go there too
You look so pretty!!!
Wow didn't even know there was a Gundam Hotel
nice glass
Cock is up!
i don't think i would be able to leave that hotel without stealing....everything
theres such a thing as a gundam hotel??0_____0 i must go there!
I would like to check into this hotel
one of my favourite photos
JEsus! A Gundam Hotel!? sorry, Gorgeous photo
looks like i'm not the only one that is surprize
looks like i'm not the only one that is surprize
pure beauty
Captivating beauty
nauthy hot girl..huh! you looks WOW!
your awesome as always, but this hotel is sweeeet!
hmmm... i rlly feel like hanging with you 0.0
I wanna go to the Gundam hotel and oop oop oop em gangnam style...hellz ya
very jealous.
you're da boss!
Great shot, composition, setting and model
So damn cute ^///^
gundam theme hotel ... that's the dream!!!
just a straight up mood setting and thought provoking photo. its def one of my faves.
Why you so beautiful!
nice one
cool Gundam
i'm constantly waking up covered in cold sweat, thinking how on Earth is it possible that such a creation beyond imagining, could have possibly come to this world...we are not worthy to share one planet with you, Vampy *infinite fanboy spazz*
Stunning beauty.
I have a wish for experiencing Japan/Tokyo myself - Looks like an awesome hotel
For a second I was like why is this white girl popping up in my watch feeds, this has to be a mistake. Upon further inspection, I have to say, "Whoops, my bad." Cute photo though.
so beautiful
Sieg Zeon!
You gave me an instant boner
Very nice hope you had a wonderful time sexy
beautiful...really very nice
sorry for my english
sorry for my english
Simple and breathtaking. x__x
You are SOOO beautiful Linda. Do you have a calendar out this year at all?
Long Vo from the bay area?
Such a hotel may blow my mind!


text:
The Pack Symbol by HyenaKlownWatch
©2006-2016 HyenaKlown
That is truly awesome and should be the new Pack Symbol ^^ I'd like to have a necklace made with the type of look to it
Beautifully Real
This is really cool looking. Normally I don't like blue, but it looks good here.
You should do more stuff like this.
You should do more stuff like this.
thanx...and ill consideer making more like this, it wuz kinda fun actually lol
Well! This is one symbol that rocks out loud.
Oh nice job! I really like it. The wolf in the background is damn nice.
ooh! i like that one! and the subtle wolf in back! nice one, z!
Tis nice. Looks more like gloss than glass though.
lol... nice
Oooooo.....very nice.


text: Q: Does tapping on the top of sealed aluminum fizzy soda cans (like diet coke for example) reduce the probability of "explosive fizz out" - where soda fizz-out goes onto the floor, your socks, etc. Assuming that tapping the can top several times does have an effect (I do not know this to be true) the only explanation I can come up with: tapping removes any [tex]CO_2[/tex] bubbles on the side surface of the can. These bubbles act as condensation nuclei. Anybody know something about this? Am I all wet? not soda-wet... Everyone here assures me that can tapping works. I dunno.


text:
All News
Don't Leave It Behind Or You May Get FinedWe have increased the amount of 'on the ground' officers who can issue on-the-spot penalties to irresponsible dog owners.
Find out more
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An unlocked phone does not need to be changed. That is, I slip in my ATT sim and it's done.
hi all. i have an older but GREAT samsung. it's the sgh d900 UNLOCKED. i need to get into the phone and change the settings from tmobile to att.
i remember there was some kind of admin code but i never took down the procedure.


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Laughing while you work was okay with Chef Curley, making the hard work that it takes in a professional kitchen seem not so hard. Poole eats at Daniel's Grille on a regular basis.
From Chef Walters he learned how to simplify his dishes. He introduced Poole to the slow movement in food, which is fresh ingredient driven cooking. The slow food movement is worldwide and started in Italy to counteract the affects of fast food.
"Walters gave me the interest in fresh foods," he said.
"Before I left the Inn to travel out west I was sourcing as much fresh ingredients as I could from local organic growers, such as Tierra Farms."
"Christopher Kuhns demonstrated the savory side of food," Poole said. "His cooking was heavier because of his French and Italian influences, but his flavor combinations were always right on."
Poole feels less is often more, as one can lose track of flavor combinations in the mouth.
Before these chefs Poole was addicted to the Great Chefs of America on television after school when he was a kid. Well, he'd first get in some cartoons and then switch over to see what the chefs were up to.
On the job at Kabuki
Now he is bringing new ideas with specials and attention to details to Kabuki's regular menu. It is his job to determine two or three specials each night. These often do not repeat and are based on what is in house and available. One recent dish started with roasted beets shaved into thin rounds as a base for wilted spinach, topped with a crabmeat lightly tossed with Parmigiano Reggiano, then topped with a grilled sea Scallop and a shrimp. The textures as well as the subtle flavors were considered when creating the dish that came together elegantly from the delicacy of the seafood to the earthiness of the beets.
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Publications (102)338.66 Total impact
Article: Role of the Perifornical Hypothalamic Monoamine Neurotransmitter Systems in Anorectic Effects of Endotoxin[Show abstract] [Hide abstract]
ABSTRACT: The cachexia-anorexia syndrome, in which patients suffering from chronic illness lack the desire to eat and experience weight loss, creates a serious clinical problem when patients are attempting to overcome the disease process. Endotoxin (ET) has many actions in the brain and peripheral injections can affect regulation of monoamines in brain areas as diverse as the olfactory lobes and the locus coeruleus. Certainly, ET is involved in the febrile process and it plays a prominent role in the regulation of food intake and maintenance of body weight during chronic illnesses. Monoamine neurotransmitters in specific regions of the hypothalamus also participate in the regulation of food intake and body weight and have been well characterized. In this regard, the hypothalamic perifornical nucleus (PFN) is of interest to our lab due to its role in drug-induced anorexia caused by amphetamines. It is also the most sensitive site in the hypothalamic monoaminergic system that involves dopamine (DA) and epinephrine (EPI). DA antagonist, stereotaxically placed in this site, can stimulate feeding, and specific injections of DA or EPI can result in a 70-90% decrease in food intake, even in food-deprived animals. We have shown in our studies that ET in a dose (0.2 mg/kg of lipopolysaccharide) that does not induce noticeable ambulatory (lack of movement) effects (related to malaise) can cause a significant decrease in food intake in lean Zucker rats. We hypothesize that exogenous ET causes an increase in the extracellular concentrations of monoamines in the perifornical hypothalamus, which in turn can mediate the decrease in food intake. Microdialysis was utilized to measure extracellular concentrations of EPI, norepinephrine, 5-hydroxyindoleacetic acid, DA, and serotonin or 5-hydroxytryptamine. These measurements were taken at a post-ET time period that coincides with an ET-induced decrease (4x) in food intake. Extracellular DA and EPI both significantly increased in the PFN in response to injection of ET. Increases in extracellular DA were dose related and were significant (p < 0.05) compared to zero baseline and saline at both doses of ET. No statistically significant differences were found in 5-hydroxyindoleacetic acid, norepinephrine, and serotonin in microdialysates of this part of the hypothalamus. The present data suggest that catecholamines, namely DA and EPI which are known to decrease food intake, in the PFN may be involved in the regulation of decreases in food intake caused by peripherally administered ET. This does not rule out a role for locally produced inflammatory molecules in the brain in this process.
Article: Dehydroepiandrosterone (DHEA) blocks the increase in food intake caused by neuropeptide Y (NPY) in the Zucker rat[Show abstract] [Hide abstract]
ABSTRACT: Recent studies have demonstrated that neuropeptide Y (NPY) reduced the neural production of dehydroepiandrosterone (DHEA) in frog hypothalamic explants. The objective of this study was to assess if DHEA can block the NPY induced increase in food intake in lean and obese Zucker rats. Rats were given one of the following four treatments: sterile water/dimethylsulfoxide (DMSO), NPY/DMSO, water/DHEA, and NPY/DHEA. Immediately after administration of their respective treatment, rats were exposed to macronutrients for 4 h and food intake was monitored. NPY caused a significant increase in total calories consumed compared to control. Co-administration of DHEA along with NPY blocked this NPY dependent effect. These results suggest that DHEA blocks the over-eating in satiated rats induced by NPY. Measurement of changes in regional hypothalamic and raphe monoamine neurotransmitters known to affect food intake suggested a possible role of serotonin fluctuations in the ventromedial hypothalamus (VMH) guiding this behaviour.
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ABSTRACT: Leptin is considered to act as a signal relating somatic energetic status to the reproductive system. However, the nature of that signal and its relationship with male reproductive function across nonhuman primate species are unclear. We suggest that species-specific differences in leptin physiology may be related to the degree of environmental variation and variation in the importance of energy stores for male reproduction. In order to test the role of seasonality in species differences among nonhuman primates, we compared leptin, testosterone, and body composition in male rhesus (n = 69) and pig-tailed (n = 43) macaques. Despite having larger abdominal fat deposits, the rhesus macaques did not exhibit significantly higher leptin levels (rhesus, 2.21 +/- 0.43 ng/ml; pig-tailed, 2.12 +/- 0.39 ng/ml). Both species showed increases in leptin across adolescent, subadult, and adult age-groups (P = 0.036 for rhesus; P = 0.0003 for pig-tailed by ANCOVA). Testosterone was not significantly associated with leptin in either the rhesus (r = 0.039; P = 0.754) or pig-tailed (r = 0.2862; P = 0.066) samples. Comparison of leptin levels across the two species using univariate modeling procedures showed no significant age-group by abdominal fat interaction. These findings suggest little difference in leptin production between these two closely related species, despite the difference in breeding seasonality.
Article: The influence of dehydroepiandrosterone and 8-OH-DPAT on the caloric intake and hypothalamic neurotransmitters of lean and obese Zucker rats[Show abstract] [Hide abstract]
ABSTRACT: The 5 HT(1A) receptor agonist 8-hydroxy-2-(di-n-propylamino)-tetraline (8-OH-DPAT) increases the food intake of satiated Zucker rats, both lean and obese. Associated with this increased intake are changes in the hypothalamic content of serotonin and its metabolite, 5-HIAA (5-hydroxyindole-3-acetic acid); serotonin is increased while the level of 5-HIAA is decreased. Analysis of individual 5-HIAA/5-hydroxytryptamine (5-HT) ratios, a measure of serotonin turnover indicate that 8-OH DPAT affected serotonin turnover equally and dramatically in both phenotypes. This would be an expected physiological action of an autofeedback mechanism by a 5-HT(1A) receptor agonist. Dehydroepiandrosterone (DHEA) at doses as low as 10 mg/kg blocks the 8-OH-DPAT-induced increase in food intake but does not alter food intake of control satiated Zucker rats. The mechanism of DHEA's action was investigated by monitoring the steroid's effect on hypothalamic neurotransmitters in this satiated model. DHEA by itself induced some change in 5-HIAA in the obese satiated model but not the lean. 8-OH-DPAT, by itself, dramatically decreased serotonin turnover in either lean or obese rats, and DHEA combined with 8-OH-DPAT did not further change serotonin turnover, suggesting DHEA may work through mechanisms other than monoamines to cause its inhibition of 8-OH-DPAT-induced behavioral effects at such low doses.
Article: Caloric Intake and Hypothalamic Neurotransmitters in Zucker Rats made Acutely Diabetic with Streptozocin[Show abstract] [Hide abstract]
ABSTRACT: Zucker rats, lean and obese, treated with low dose intraperitoneal injections of streptozocin become hyperglycemic within 24h. Insulin levels fall, although the obese animal remains hyperinsulinemic. Associated with these changes in glucose and insulin there are transient decreases in caloric intake. Macronutrient selection studies show that protein consumption decreases. There is a trend for fat intake to decrease. The levels of hypothalamic neurotransmitters in the lean animals are not altered by streptozocin. The levels of 5-hydroxyindoleacetic acid increases in the streptozocin-treated obese animal in the paraventricular region, ventromedial region and the raphe. Serotonin is also significantly increased in the paraventricular region of the obese rat. These results suggest that acutely, treatment with streptozocin injures pancreatic islets, causing, in turn, decreases in insulin levels so that hyperglycemia ensues in both phenotypes. Associated with these perturbations are decreases in caloric intake. The magnitude of change in insulin levels is much greater in the obese rat. It is hypothesized that in the obese Zucker rat decrements in food intake are mediated by increase in serotonin turnover in the hypothalamus and these changes are related to changes of insulin levels. These data support the concept that circulating insulin affects hypothalamic neurotransmitters.
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ABSTRACT: Morphometric and hormonal measures were collected from 21 captive savanna baboons (Papio cynocephalus) maintained at the Tulane National Primate Research Center in order to determine age-related patterns in leptin levels over the life course as well as their relationships to body composition and adrenal and gonadal steroids. Comparison of leptin levels between peri-pubertal, adolescent, young adult, and fully mature males show lower levels among adolescent as compared with young adult males (P = 0.05 by Kruskal-Wallis ANOVA). In addition, abdominal fat varied among age groups (P = 0.003 by Kruskal-Wallis ANOVA) with the peri-pubertal animals lower than the adolescents, young adults, and prime adults. However leptin was not related to any measure of body composition, including abdominal fat, or to adrenal hormones (dehydroepiandrosterone, dehydroepiandrosterone-sulfate, and cortisol) or gonadal hormones (testosterone and estradiol). Age-related changes in leptin appear similar to those reported for captive rhesus macaques, while the failure to find an association between leptin and abdominal fat is interestingly different. These results confirm elevated levels of leptin in captive baboons compared with their wild counterparts and suggest that they result from changes in fetal development.
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ABSTRACT: Morphometric and hormonal measures were collected from 21 captive savanna baboons (Papio cynocephalus) maintained at the Tulane National Primate Research Center in order to determine age-related patterns in leptin levels over the life course as well as their relationships to body composition and adrenal and gonadal steroids. Comparison of leptin levels between peri-pubertal, adolescent, young adult, and fully mature males show lower levels among adolescent as compared with young adult males (P = 0.05 by Kruskal–Wallis ANOVA). In addition, abdominal fat varied among age groups (P = 0.003 by Kruskal–Wallis ANOVA) with the peri-pubertal animals lower than the adolescents, young adults, and prime adults. However leptin was not related to any measure of body composition, including abdominal fat, or to adrenal hormones (dehydroepiandrosterone, dehydroepiandrosterone-sulfate, and cortisol) or gonadal hormones (testosterone and estradiol). Age-related changes in leptin appear similar to those reported for captive rhesus macaques, while the failure to find an association between leptin and abdominal fat is interestingly different. These results confirm elevated levels of leptin in captive baboons compared with their wild counterparts and suggest that they result from changes in fetal development.
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ABSTRACT: Numerous studies have suggested important and varying roles for dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEA-S) in primate physiological functions. Despite these numerous claims, specific actions and significance of DHEA and DHEA-S are still equivocal. A decline of these hormones in adult humans may have functional significance, yet there is no clear relationship between functional impairments of aging and the decline in DHEA or DHEA-S levels. This current study attempts to address the natural history of adrenal hormones by presenting non-human primate evidence of the endocrinology of aging; the age-related patterns of adrenal hormone decline in three species of the subfamily Cercopithecinae, Macaca mulatta, Macaca nemestrina, and Papio cynocephalus are compared. It is concluded that DHEA-S and cortisol represent lineage specific markers of senescence among primates and that parallel age-related patterns of DHEA-S and cortisol likely reflect lineage specific effects, or rather, phylogenetic similarities of endocrine senescence. The use of relative adrenal hormone levels to approximate species' life expectancies is discussed.
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ABSTRACT: Though baboons have been considered an appropriate non-human primate model for studying human reproductive and endocrine development, the overall similarity of reproductive maturation between the two species is unclear. This paper examines the role of testicular and adrenal hormones for pubertal changes in a cross-sectional sample of 21 captive male savanna baboons. Morphometric and hormonal indices demonstrate changes in size and gonadal function, but not adrenal function, during pubertal maturation among baboons. Results also indicate that gonadal, but not adrenal, androgens are related to morphometric variables. We conclude that savanna baboons do not make an appropriate evolutionary model of human pubertal maturation.
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ABSTRACT: Treatments of human and rodent obesity frequently involve administration of amphetamine derivatives, much like phenylpropanolamine, which suppress food intake. The Zucker rat is a commonly employed model of youth-onset obesity in which the homozygous genotype manifests hyperphagia as well as other characteristics that parallel human obesity. Using a macronutrient selection procedure, we examined phenylpropanolamine's differential actions in controlling dietary intake, spontaneous open-field activity, and regional hypothalamic neurotransmitter levels in obese female Zucker rats of varying fat food preference. We hypothesized that phenylpropanolamine would alter hypothalamic monoamine levels differently in low-fat preferring and high-fat preferring Zucker rats, and hence affect feeding behavior and activity differently in these two groups. It was found that in high-fat preferring animals, phenylpropanolamine significantly decreased spontaneous open-field activity, decreased only carbohydrate caloric intake, and increased serotonin and 5-HIAA levels in the paraventricular nucleus (PVN). In low-fat preferring animals, phenylpropanolamine decreased carbohydrate, protein, and total caloric intake, had no significant effect of spontaneous activity, and increased serotonin and 5-hydroxyindole acetic acid levels in the PVN. Inherent and induced physiological differences of low-fat and high-fat preferring animals are discussed as well as phenylpropanolamine's potential in combination drug therapy for the treatment of human hyperphagic obesity.
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ABSTRACT: Hypothalamic neurotransmitter levels were compared between groups of Zucker rats. Animals were grouped by gender, phenotype and preference for dietary fat. Before sacrifice all animals consumed a standard rat chow diet and were fasted overnight. Five rats from each of eight groups were assayed. Hypothalamic regions (lateral, LH; ventromedial, VMH; paraventricular, PVN) and the raphe were isolated and analyzed for dopamine, norepinephrine, epinephrine, serotonin and 5-hydroxyindoleacetic acid. A factorial analysis of variance was used to compare the concentrations of these biogenic amines in the four regions across phenotypic, gender and fat preference profiles. No differences were demonstrated between groups based upon fat food preference. Epinephrine and 5-HIAA content varied between lean and obese animals but there were no differences in the content of serotonin, norepinephrine or dopamine. The results are consistent with the hypothesis that the obese animal eats more because it releases less of the satiety-inducing neurotransmitter serotonin in the hypothalamus.
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ABSTRACT: Insulin-resistant muscle tissue contains low proportions of arachidonic acid (AA), and increased proportions of muscle AA correlate with improved insulin sensitivity. Dehydroepiandrosterone (DHEA) and AA, like the thiazolidinedione drugs that decrease insulin resistance (IR), are peroxisome proliferators. Long-chain fatty acids (FA) have been named the "one true" endogenous ligand for activating the peroxisome proliferator-activator receptor (PPAR), and DHEA has been named a "good candidate" as a naturally occurring indirect activator of PPAR. This study was conducted to determine DHEA's effects on lipid profiles of skeletal and cardiac muscle in lean and obese Zucker rats (ZR), a model of IR, type 2 diabetes mellitus, and obesity. We hypothesize that DHEA may alter long-chain FA profiles in muscle tissue of obese rats such that they more closely resemble that of the lean. In our experiments, we employed a DHEA and a pair-fed (PF) group (n = 6) for 12 lean and 12 obese ZR. For 30 d, the diet of the two DHEA groups was supplemented with 0.6% DHEA; PF groups were given the average daily calories consumed by their corresponding treatment group. Hearts and gastrocnemius muscles were assayed for phospholipid (PL), free FA, and triglyceride (TG) FA profiles. The proportion of PL AA was significantly greater in both muscle types of lean compared to obese rats. Hearts from both DHEA groups had greater PL proportions of AA and less oleic (18:1) acid than their PF controls. Likewise, 18:1 proportions were significantly lower in the gastrocnemius; however, AA proportions were not significantly different. Similar phenotypic profile differences were observed in the TG fraction of both muscle types. There were no DHEA-related TG FA profile alterations.
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ABSTRACT: Though baboons have been considered an appropriate non-human primate model for studying human reproductive and endocrine development. the overall similarity of reproductive maturation between the two species is unclear. This paper examines the role of testicular and adrenal hormones for pubertal changes in a cross-sectional sample of 21 captive male savanna baboons. Morphometric and hormonal indices demonstrate changes in size and gonadal function, but not adrenal function, during pubertal maturation among baboons. Results also indicate that gonadal, but not adrenal, androgens are related to morphometric variables. We conclude that savanna baboons do not make an appropriate evolutionary model of human pubertal maturation.
Article: Can associations between free fatty acid levels and metabolic parameters determine insulin resistance development in obese Zucker rats?[Show abstract] [Hide abstract]
ABSTRACT: Elevated levels of serum free fatty acids (FFA) may be the metabolic alteration in obesity that leads to insulin resistance (IR) and type 2 diabetes mellitus (DM). The obese Zucker rat (ZR) is a genetic model of juvenile-onset obesity and type 2 DM. Compared with its lean sibling, the obese ZR is hyperinsulinemic, hypertriglyceridemic, and, beginning at about 6 months, hyperglycemic. The obese ZR demonstrates also IR, hyperphagia, increased lipogenesis, adipocyte hypertrophy and hyperplasia, and increased serum FFA levels. This study was designed to determine if serum FFA levels in lean and obese ZRs correlate with metabolic parameters associated with altered energy metabolism and IR. We hypothesized that serum FFA levels correlate with such serum parameters such as insulin, glucose, triglyceride, and total cholesterol, as well as such tissue parameters as retroperitoneal, perirenal, and epididymal fat pad weights and liver total lipid content. Twenty lean and 20 obese ZR were age/weight matched. For 14 days each rat had ad libitum access to a single bowl diet that was 50% fat, 30% carbohydrate, and 20% protein. Body weights and caloric intakes were measured daily. After 14 days, all animals were fasted overnight and euthanized. Serum and tissue measurements were made and various parameters were correlated with FFA levels. Serum FFA levels were almost 2 times higher in the obese ZR (approximately 1 mmol/L) compared to the lean (approximately 0.6 mmol/L). Each variable measured was significantly (p < or = 0.05) greater in the obese ZR compared to the lean. There were significant correlations between serum FFA levels and certain variables when data from all ZR were plotted against serum and tissue parameters. However, within phenotypes, there were no significant correlations. Serum FFA levels predict serum and tissue parameters that accompany obesity and IR when comparing lean and obese rats. However, FFA do not predict such parameters within one phenotype.
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ABSTRACT: High levels of serum free fatty acids (FFA) and lower proportions of polyunsaturated (PU) FAs, specifically arachidonic acid (AA), are common in obesity, insulin resistance (IR), and type 2 diabetes mellitus. Dehydrepiandrosterone (DHEA) decreases body fat content, dietary fat consumption, and insulin levels in obese Zucker rats (ZR), a genetic model of human youth onset obesity and type 2 diabetes. This study was conducted to investigate DHEA's effects on lean and obese ZR serum FFA levels and total lipid (TL) FA profiles in heart and soleus muscle. We postulated that DHEA alters serum FFA levels and tissue TL FA profiles of obese ZR so that they resemble the levels and profiles of lean ZR. If so, DHEA may directly or indirectly alter tissue lipids, FFA flux, and perhaps lower IR in obese ZR. Lean and obese male ZR were divided into six groups with 10 animals in each: obese ad libitum control, obese pair-fed, obese DHEA, lean ad libitum control, lean pair-fed, and lean DHEA. All animals had ad libitum access to a diet whose calories were 50% fat, 30% carbohydrate, and 20% protein. Only the diets of the DHEA treatment groups were supplemented with 0.6% DHEA. Pair-fed groups were given the average number of calories per day consumed by their corresponding DHEA group, and ad libitum groups had 24-h access to the DHEA-free diet. Serum FFA levels and heart and soleus TL FA profiles were measured. Serum FFA levels were higher in obese (approximately 1 mmol/L) compared to lean (approximately 0.6 mmol/L) ZR, regardless of group. In hearts, monounsaturated (MU) FA were greater and PU FA were proportionally lower in obese compared to the lean rats. In soleus, saturated and MU FA were greater and PU FA were proportionally lower in the obese compared to the lean rats. DHEA groups displayed significantly increased proportions of TL AA and decreased oleic acid in both muscle types. Mechanisms by which DHEA alters TL FA profiles are a reflection of changes occurring within specific lipid fractions such as FFA, phospholipid, and triglyceride. This study provides initial insights into DHEA's lipid altering effects.
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ABSTRACT: The obese Zucker rat exhibits insulin resistance, develops nephropathy at an early age, and may be a model of diabetic nephropathy. Dehydroepiandrosterone (DHEA) may ameliorate many of the factors that contribute to diabetic nephropathy, while angiotensin-converting enzyme inhibitors are known to be effective. One marker of nephropathy is the expression of alpha-smooth muscle actin. We studied the effect of DHEA on the expression of alpha-smooth muscle actin in obese Zucker rats and compared the changes with those in a control group, a group given quinapril, and a group on a low-calorie diet. DHEA (0.6%) added to plain chow, quinapril (0.3 mg/kg) added to drinking water, and a low-calorie diet based on pair-feeding were administered to obese rats from age 4 to 20 weeks. Immunohistochemical expression of alpha-smooth muscle actin, a marker of interstitial and glomerular fibrosis and an early indicator of nephropathy, was measured semiquantitatively in glomeruli, cortical interstitium, and medullary interstitium on a scale of 0 to 4 and was reported as mean +/- SEM. When compared with the obese control group, quinapril exhibited a marked reduction in alpha-smooth muscle actin staining in glomeruli, cortical interstitium, and medullary interstitium (P < 0.0005); DHEA reduced alpha-smooth muscle actin staining in cortical interstitium and medullary interstitium (P < 0. 005), and a low-calorie diet reduced alpha-smooth muscle actin staining in cortical and medullary interstitium (P < 0.005), which was similar to the effects of DHEA. DHEA was similar to a low-calorie diet in reducing the immunohistochemical staining of alpha-smooth muscle actin in obese Zucker rats. However, quinapril exerted a marked protective effect on the development of fibrosis, as indicated by alpha-smooth muscle actin staining, which was significantly less than that of DHEA at the doses studied.
Article: Relationship between plasma cyclo (His-Pro), a neuropeptide common to processed protein-rich food, and C-peptide/insulin molar ratio in obese women[Show abstract] [Hide abstract]
ABSTRACT: Cyclo (His-Pro) (CHP) is a gut-brain peptide whose plasma levels in humans are increased after glucose ingestion and preferentially altered by oral glucose ingestion compared to intravenous administration in rats, suggesting a role in the enteroinsular response to nutrient ingestion. We were interested in examining levels of CHP in women of differing weights and comparing these levels to various parameters of insulin secretion. Plasma from 26 fasting, nondiabetic women ranging from 21 to 70 years of age and weighing 43 to 114 kg was assayed for CHP. Insulin and C-peptide levels were measured in 17 of the 26. Fasting CHP levels were elevated in obese compared to nonobese women (2075+/-144 vs. 905+/-187 pg/ml; p < 0.001) and were related by regression analysis to weight (r = 0.668, p < 0.001) and body mass index (r = 0.636, p = 0.001). The fasting C peptide/insulin molar ratio, which may be used as an estimate of hepatic insulin clearance (HIC), was inversely related to CHP levels (r = -0.568, p = 0.017). We conclude CHP levels are increased in obese women and inversely related to their C-peptide/insulin molar ratio. The elevation of CHP in those with a decrease in this estimate of HIC (obese) is interesting as the greater insulin response seen in normal persons after oral glucose compared to intravenous glucose has been postulated to be due to a decrease in HIC by some gut factor. The presence of such a factor in excess in the obese might explain part of their hyperinsulinemia.
Article: A preliminary study of dehydroepiandrosterone response to low-dose ACTH in chronic fatigue syndrome and in healthy subjects[Show abstract] [Hide abstract]
ABSTRACT: Abnormalities of the production of dehydroepiandrosterone (DHEA), the adrenal androgen, have been linked with disorders such as obesity and psychological disorders such as major depression. Adrenocorticotropin (ACTH) is the primary stimulant of DHEA, and cortisol, from the adrenal. We chose to examine the DHEA and DHEA/cortisol response to the novel low-dose ACTH test in healthy subjects and a cohort with chronic fatigue syndrome (CFS): this test is useful in assessing subtle irregularities of pituitary-adrenal activity. Nineteen CFS subjects (diagnosed by CDC criteria) and 10 healthy subjects were examined. We demonstrated that 1 microg ACTH significantly elevates DHEA levels, with no difference in output between CFS and healthy subjects. The DHEA/cortisol ratio decreased in response to ACTH stimulation in healthy subjects but not in the CFS cohort. We suggest this divergence of response between the two groups represents an imbalance in the relative synthetic pathways of the CFS group which, if present chronically and if comparable to daily stressors, may manifest itself as an inappropriate response to stress. This difference may be important in either the genesis or propagation of the syndrome.
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ABSTRACT: When allowed to select between macronutrients in a 1-h-a-day meal paradigm, Zucker rats consume 20-80% of their total caloric intake as fat. If they receive an intraperitoneal injection of DHEA 2 h before such a test meal, they consume fewer total calories. The magnitude of this effect on each macronutrient depends upon the animal's initial preference for fat; the higher the initial fat preference, the more profound is the decrease in caloric intake and the more pronounced the effect on fat consumption. Doses as low as 25 mg DHEA/kg body weight are effective. Lean Zucker rats that prefer to consume a high-fat diet have higher epinephrine and dopamine levels in select regions of the hypothalamus known to control food intake. Administration of DHEA to such animals 2 h before decapitation reduces the content of norepinephrine and these monoamines to levels that mimic the values found in the low-fat-preferring animals. It is hypothesized that exogenous DHEA causes the acute release of norepinephrine, epinephrine, and dopamine in select regions of the hypothalamus, and this release causes a decrease in food intake, particularly fat.
Top Journals
Louisiana State University Health Sciences Center New Orleans
Shreveport, LA, United States
- • Center for Neuroscience
- • Department of Medicine
- • Section of Pediatric Endocrinology
Yale University
New Haven, CT, United States
- Department of Anthropology
Louisiana State UniversityBaton Rouge, Louisiana, United States
LSU Medical Center
New Orleans, Louisiana, United States
- Department of Medicine