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At Vision Direct, delivering a great customer service is our top priority. As the UK's largest online contact lens retailer, we're trusted by over 700,000 people to safely deliver their contact lenses on time and we take this very seriously. If you ever experience any problems with your order or product, we're here to help. Our customer service team are available 8am – 8pm, 7 days a week. Give us a call on 020 7768 5000 or email us - firstname.lastname@example.com.
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Nether Poppleton, YORK YO26 6RB
Please send International returns to: Vision Direct BV, Distelweg 80-G, 1031hh, Amsterdam, The Netherlands
That's no problem. If you go for an eye check and your prescription has changed, just return any leftover lenses, unopened and in their original, undamaged box and we'll refund your money – provided it's within six months of you buying the lenses. We'll refund your account within seven working days once we've checked the returned products. Naturally, we'll be happy to supply replacement lenses to your new prescription.
Thankfully it doesn't happen very often at all. But if you receive the wrong products, or they're somehow damaged in transit, simply return them to us. Then, we'll supply the products you wanted (if the cost is less, we'll refund the difference; if it's higher, we'll amend your invoice accordingly). If you prefer, return the order and we'll refund your money.
If it turns out that you receive your order and you're just not happy with it for any reason, you may return any unopened, unmarked boxes to us within seven days of you receiving your order for a full refund on all the products. We'd like to say 'no questions asked'. But, actually, we'll probably ask you what was wrong – just so we can improve things for next time.
We are happy to cancel any order that has not yet dispatched. If you realise that you've ordered something in error and would like to amend or cancel it please call our customer service team immediately:
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subset: commoncrawl


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Upcoming Events
This week, communities across the country commemorate Black History Month with screenings celebrating the life of civil rights leaders and engaging in critical dialogue about contemporary social issues.
Report Back: 'The Genius of Marian' on Capitol Hill
On Monday, The Genius of Marian screened on Capitol Hill. Actor and activist David Hyde Pierce, Senator Debbie Stabenow (D-MI), and Devon White Angelini, featured in the film, spoke at the event. Read more about the screening and discussion.
Listening Tour Kicks Off in San Francisco: A Report
A report back from "Independent Film on PBS: A National Listening Tour" in partnership with ITVS, POV, Independent Lens, and WNET from San Francisco. The next event will be on February 23, 2015 in New York City.
Teaching Op-Docs
In teaching a junior-level news and reporting course this semester, I have decided to use The New York Times's Op-Docs as a production model for thinking about news within online journalism.
POV Digital Storytelling Tools: Using Virtual Reality for Data Visualization
Virtual reality provides a new way to create immersive experiences based on data. View the demo (Oculus Rift optional) and download the source code.
Documentary Streaming Free for MLK Day: 'Brother Outsider: The Life of Bayard Rustin'
Long before Martin Luther King Jr. became a national figure, Bayard Rustin routinely put himself on the line as a crusader for racial justice. But he was also seen as a political liability because he was gay.
Meet the Programmers Behind the Flaherty NYC Winter/Spring 2015 Series
This season's Flaherty NYC's series begins in January with the theme "That Obscure Object of Desire." Programmers Pacho Velez and Sierra Pettengill discuss choosing films that explore "the mysterious power of objects."
Oscar Predictions 2015: And the nominees are…
Doc Soup Man reflects on his Oscar nomination predictions -- after finding out he got only 60 percent right -- and checks in with two nominated filmmakers.
Oscar Predictions 2015: And the nominees will be…
Doc Soup Man is not one to shy away from predictions. His thoughts on which documentaries will be nominated for the Oscars in 2015.
POV Among New Fledgling Fund Grantees
POV is thrilled to be a part of an inspiring class of new Fledgling Fund grantees.
Documentary Community Gathers at 2015 Cinema Eye Honors
If there is ever a question whether or not there's an actual community of documentary filmmakers, the first bit of evidence should be the Cinema Eye Honors.
In Memory of Kartemquin Films Co-Founder Jerry Blumenthal
Kartemquin Films founding member Jerry Blumenthal passed away in November. From POV's archive, watch an interview with Jerry Blumenthal and his POV documentary, Golub, which we are now streaming free.
Tom Roston's Top 10 Documentaries of 2014
Without any throat clearing about how this was yet another great year for docs -- which it was, by the way -- I present my favorite nonfiction films of 2014
The Best Documentaries of 2014
What's the best documentary of 2014? We're tracking festivals, critics, blogs, award shows and more to determine the top docs of the year.
With 'Life Itself,' Steve James Has Earned the Right to Oscar
He's already been robbed of one. After decades of making documentaries, Steve James has earned the right to be recognized with an Oscar.
POV Digital Storytelling Tools: Explore the Real World in Virtual Reality
Fly through any city in virtual reality through your web browser and Oculus Rift with this new tool from POV. (And build on the source code.)
POV Digital Storytelling Tools: Adding a New Dimension to Archival Photography
How the team from the interactive documentary Camp Century brought static photographs to life, and how you can use the technology for your next project.
Dispatches from IDFA: All the Young Dudes
Kel O'Neill discusses the lack of diversity at the IDFA DocLab conference, and the effect of its absence.


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|I'm not even a business student but I felt the...I'm not even a business student but I felt the need to reply to this. I attended the University of British Columbia for my undergraduate degree, which I achieved with honours and, according to some of these scales, a 3.7 GPA. I have professors educated at the top private universities in the States...
|7 years 8 months


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SAN FRANCISCO – Pablo Sandoval stood out like a sore orange thumb among the Giants taking early batting practice and ground balls Friday afternoon, preparing to begin the second half of what has been a tumultuous season so far against the division-leading Arizona Diamondbacks.
While most players wore the Giants' black warmup tops, Sandoval sported an orange T-shirt taking his turn in the cage, hitting a ball on his last swing that caromed off the brick wall in right-center field into the bleachers. The shirt was marked with sweat as Sandoval sat at his locker shortly thereafter and sunk into a cough – a product, he said, of spending a few days in the heat of his native Venezuela over the All-Star break.
"Daughter time," Sandoval said with a smile.
For the first time since 2010, Sandoval was not part of the festivities when baseball's All-Stars, including his manager and four teammates, convened in New York this week. After a good start that had him hitting above .300 as late as May 25, Sandoval missed 14 games in June to a strained foot and, upon his return June 24, fell squarely into the Giants' team-wide slump.
Sandoval didn't drive in a run in his first 13 games back and hit .118 as the Giants went 2-11 in those games, part of their 8-20 slide to end the first half. While certainly not the lone culprit, Sandoval's return had come with hopes he could give the lineup a spark, and his production dimmed those hopes. Sandoval left for home last week having batted .266 with nine homers and 42 RBIs in the first half.
"It was a good break for me without baseball for a couple days," Sandoval said. "You need that break to refresh your mind. Now I get back into this thing."
The same, Sandoval agreed, could be said for the team. After going into the break 6 1/2 games out of first place in the National League West, the Giants returned to AT&T Park on Friday with a chance to take an immediate cut out of that deficit with three games against the Diamondbacks. Though eight games under .500, Sandoval said the Giants were going in with a "good mind," partly because of an encouraging series in San Diego that ended the first half.
The Giants won three of four, and Sandoval went 6 for 15 in the series, hitting his first home run since May 21. Sandoval said he didn't feel markedly better, "I just saw more pitches and tried to have good at-bats, put the ball in play and got good results."
They're results the Giants would certainly take more of from a player they hope can be a consistent run producer. Sandoval said his foot is "100 percent" and he "feels great at the plate now" after needing some time upon his return to regain the timing of his hitting.
Manager Bruce Bochy had Sandoval, having gone 9 for 27 in his past seven games, in the cleanup spot Friday protecting Buster Posey.
Asked if he feels he needs to do more offensively in the second half, Sandoval said: "It's not about me, it's about team. Play like a team, stay like a team, and you're going to see the results. If everybody comes to the same page, we're going to win some games."
If the Giants are going to make a push, this nine-game homestand may be crucial. The Giants were 25-20 at AT&T Park entering Friday. The homestand carries them to the brink of the trade deadline, where it's still not clear whether the Giants will be trying to add pieces or offload them. Bochy, though, said before Friday's game he doesn't want his players looking beyond the day.
"Really every pitch, every play is so important to us right now because we're behind," he said. "We don't have the margin for error that some other clubs have. So every game is critical."
Et cetera – Ryan Vogelsong is scheduled to face hitters in live batting practice today for the first time since fracturing his right little finger. He could begin a rehab assignment early next week depending on how he responds.
Vogelsong, on the disabled list since May 21, would likely begin his rehab at Class-A San Jose, where the Giants would like him to work up to 80 pitches. Dates are not set, but Bochy said Vogelsong could rejoin the Giants' rotation as early as the second week of August.
Bochy said infielder Joaquin Arias (appendicitis), who is eligible to come off the DL on Tuesday, will probably need two or three days beyond that before he's ready to return.
Angel Pagan has begun doing agility drills and swinging a bat, which puts him ahead of where Bochy figured the outfielder would be at this point in his recovery from hamstring tendon surgery, and Bochy sounded optimistic Pagan could return this season.
Call The Bee's Matt Kawahara, (916) 321-1015. Read his Bay Area Baseball blog at blogs.sacbee.com/bay-area-baseball/. Follow him on Twitter @matthewkawahara.


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Proteomics for prediction and characterization of response to infliximab in Crohn's disease: a pilot study.
Meuwis, Marie-Alice ; Fillet, Marianne ; Lutteri, Laurence et al
in Clinical Biochemistry (2008), 41(12), 960-7
OBJECTIVES: Infliximab is the first anti-TNFalpha accepted by the Food and Drug Administration for use in inflammatory bowel disease treatment. Few clinical, biological and genetic factors tend to predict ... [more ▼]
OBJECTIVES: Infliximab is the first anti-TNFalpha accepted by the Food and Drug Administration for use in inflammatory bowel disease treatment. Few clinical, biological and genetic factors tend to predict response in Crohn's disease (CD) patient subcategories, none widely predicting response to infliximab. DESIGN AND METHODS: Twenty CD patients showing clinical response or non response to infliximab were used for serum proteomic profiling on Surface Enhanced Lazer Desorption Ionisation-Time of Flight-Mass Spectrometry (SELDI-TOF-MS), each before and after treatment. Univariate and multivariate data analysis were performed for prediction and characterization of response to infliximab. RESULTS: We obtained a model of classification predicting response to treatment and selected relevant potential biomarkers, among which platelet aggregation factor 4 (PF4). We quantified PF4, sCD40L and IL-6 by ELISA for correlation studies. CONCLUSIONS: This first proteomic pilot study on response to infliximab in CD suggests association between platelet metabolism and response to infliximab and requires validation studies on a larger cohort of patients. [less ▲]Detailed reference viewed: 131 (26 ULg)
New biomarkers of Crohn's disease: serum biomarkers and development of diagnostic tools
Meuwis, Marie-Alice ; Fillet, Marianne ; Chapelle, Jean-Paul et al
in Expert Review of Molecular Diagnostics (2008), 8Detailed reference viewed: 73 (11 ULg)
Monomeric calgranulins measured by SELDI-TOF mass spectrometry and calprotectin measured by ELISA as biomarkers in arthritis
De Seny, Dominique ; Fillet, Marianne ; Ribbens, Clio et al
in Clinical Chemistry (2008), 54
BACKGROUND: SELDI-TOF mass spectrometry (MS) is a high-throughput proteomic approach with potential for identifying novel forms of serum biomarkers of arthritis. METHODS: We used SELDI-TOF MS to analyze ... [more ▼]
BACKGROUND: SELDI-TOF mass spectrometry (MS) is a high-throughput proteomic approach with potential for identifying novel forms of serum biomarkers of arthritis. METHODS: We used SELDI-TOF MS to analyze serum samples from patients with various forms of inflammatory arthritis. Several protein profiles were collected on different Bio-Rad Laboratories ProteinChip arrays (CM10 and IMAC-Cu(2+)) and were evaluated statistically to select potential biomarkers. RESULTS: SELDI-TOF MS analyses identified several calgranulin proteins [S100A8 (calgranulin A), S100A9 (calgranulin B), S100A9*, and S100A12 (calgranulin C)], serum amyloid A (SAA), SAA des-Arg (SAA-R), and SAA des-Arg/des-Ser (SAA-RS) as biomarkers and confirmed the results with other techniques, such as western blotting, immunoprecipitation, and nano-LC-MS/MS. The S100 proteins were all able to significantly differentiate samples from patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS) from those of patients with inflammatory bowel diseases used as an inflammatory control (IC) group, whereas the SAA, SAA-R, and SAA-RS proteins were not, with the exception of AS. The 4 S100 proteins were coproduced in all of the pathologies and were significantly correlated with the plasma calprotectin concentration; however, these S100 proteins were correlated with the SAA peak intensities only in the RA and IC patient groups. In RA, these S100 proteins (except for S100A12) were significantly correlated with the serum concentrations of C-reactive protein, matrix metalloproteinase 3, and anti-cyclic citrullinated peptide and with the Disease Activity Score (DAS(28)). CONCLUSIONS: The SELDI-TOF MS technology is a powerful approach for analyzing the status of monomeric, truncated, or posttranslationally modified forms of arthritis biomarkers, such as the S100A8, S100A9, S100A12, and SAA proteins. The fact that the SELDI-TOF MS data were correlated with results obtained with the classic calprotectin ELISA test supports the reliability of this new proteomic technique. [less ▲]Detailed reference viewed: 64 (20 ULg)
Further insights in the mechanisms of interleukin-1beta stimulation of osteoprotegerin in osteoblast-like cells
Lambert, Cécile ; Oury, Cécile ; Dejardin, Emmanuel et al
in Journal of Bone and Mineral Research (2007), 22(9), 1350-1361
The mechanisms of IL-1beta stimulation of OPG were studied in more detail. Whereas p38 and ERK activation was confirmed to be needed, NF-kappaB was not necessary for this regulation. We also found that ... [more ▼]
The mechanisms of IL-1beta stimulation of OPG were studied in more detail. Whereas p38 and ERK activation was confirmed to be needed, NF-kappaB was not necessary for this regulation. We also found that OPG production after IL-1beta stimulation was not sufficient to block TRAIL-induced apoptosis in MG-63 cells. INTRODUCTION: Osteoprotegerin (OPG) plays a key role in the regulation of bone resorption and is stimulated by interleukin (IL)-1beta. Herein, we defined the mechanisms of IL-1beta stimulation of OPG focusing on the potential involvement of MAPK and NF-kappaB. We also examined whether OPG production in response to IL-1beta influences TRAIL-induced apoptosis in MG-63 cells. MATERIALS AND METHODS: OPG mRNA levels in MG-63 cells were quantified by real-time RT-PCR and protein levels of OPG and IL-6 by ELISA. Cell viability was assessed using the methyltetrazidium salt (MTS) reduction assay. The role of the MAPK pathway was studied by both Western blotting and the use of specific chemical inhibitors. NF-kappaB function was studied using BAY 11-7085 and by siRNA transfection to inhibit p65 synthesis. Transcription mechanisms were analyzed by transiently transfecting MG-63 cells with OPG promoter constructs. Post-transcriptional effects were examined by using cycloheximide and actinomycin D. RESULTS: MG-63 cells treatment with IL-1beta resulted in the phosphorylation of c-Jun NH(2)-terminal kinase (JNK), p38, and extracellular signal-regulated kinase (ERK). The use of the specific inhibitors showed that p38 and ERK but not JNK were needed for IL-1beta-induced OPG production. In contrast, NF-kappaB was not essential for IL-1beta induction of OPG. We also showed a small transcriptional and a possible post-transcriptional or translational regulation of OPG by IL-1beta. Exogenous OPG blocked TRAIL-induced apoptosis, but IL-1beta induction of OPG did not influence TRAIL-induced cell death. CONCLUSIONS: IL-1beta stimulates OPG production by mechanisms dependent on p38 and ERK. In contrast, NF-kappaB was not essential for this regulation. Although the relevance of IL-1beta stimulation of OPG is still not fully understood, our data showed that IL-1beta stimulation of OPG does not modify TRAIL-induced cell death. [less ▲]Detailed reference viewed: 63 (21 ULg)
Polyubiquitination of the scaffold protein tank/I-traf: implications for the TLR-mediated signalling pathways
GATOT, Jean-Stéphane ; ; Chau, Tieu-Lan et al
Poster (2007, March)Detailed reference viewed: 19 (7 ULg)
A role for the transcriptional complex elongator in cell migration and spreading
; Close, Pierre ; et al
Poster (2007, March)Detailed reference viewed: 15 (3 ULg)
Biomarker discovery for inflammatory bowel disease, using proteomic serum profiling
Meuwis, Marie-Alice ; Fillet, Marianne ; Geurts, Pierre et al
in Biochemical Pharmacology (2007), 73(9), 1422-1433
Crohn's disease and ulcerative colitis known as inflammatory bowel diseases (IBD) are chronic immuno-inflammatory pathologies of the gastrointestinal tract. These diseases are multifactorial, polygenic ... [more ▼]
Crohn's disease and ulcerative colitis known as inflammatory bowel diseases (IBD) are chronic immuno-inflammatory pathologies of the gastrointestinal tract. These diseases are multifactorial, polygenic and of unknown etiology. Clinical presentation is non-specific and diagnosis is based on clinical, endoscopic, radiological and histological criteria. Novel markers are needed to improve early diagnosis and classification of these pathologies. We performed a study with 120 serum samples collected from patients classified in 4 groups (30 Crohn, 30 ulcerative colitis, 30 inflammatory controls and 30 healthy controls) according to accredited criteria. We compared protein sera profiles obtained with a Surface Enhanced Laser Desorption Ionization-Time of Flight-Mass Spectrometer (SELDI-TOF-MS). Data analysis with univariate process and a multivariate statistical method based on multiple decision trees algorithms allowed us to select some potential biomarkers. Four of them were identified by mass spectrometry and antibody based methods. Multivariate analysis generated models that could classify samples with good sensitivity and specificity (minimum 80%) discriminating groups of patients. This analysis was used as a tool to classify peaks according to differences in level on spectra through the four categories of patients. Four biomarkers showing important diagnostic value were purified, identified (PF4, MRP8, FIBA and Hpalpha2) and two of these: PF4 and Hpalpha2 were detected in sera by classical methods. SELDI-TOF-MS technology and use of the multiple decision trees method led to protein biomarker patterns analysis and allowed the selection of potential individual biomarkers. Their downstream identification may reveal to be helpful for IBD classification and etiology understanding. [less ▲]Detailed reference viewed: 168 (18 ULg)
Contribution of proteomics to colorectal cancer diagnosis
Meuwis, Marie-Alice ; Louis, Edouard ; Merville, Marie-Paule
in Acta Endoscopica (2007)Detailed reference viewed: 54 (5 ULg)
Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear factor-kappaB
; ; et al
in Oncogene (2006), 25(42), 5708-5718
Overexpression of cyclooxygenase-2 (Cox-2) is thought to exert antiapoptotic effects in cancer. Here we show that the tumor suppressor p53 upregulated Cox-2 in esophageal and colon cancer cell lines by ... [more ▼]
Overexpression of cyclooxygenase-2 (Cox-2) is thought to exert antiapoptotic effects in cancer. Here we show that the tumor suppressor p53 upregulated Cox-2 in esophageal and colon cancer cell lines by inducing the binding of nuclear factor-kappaB (NF-kappaB) to its response element in the COX-2 promoter. Inhibition of NF-kappaB prevented p53 induction of Cox-2 expression. Cooperation between p53 and NF-kappaB was required for activation of COX-2 promoter in response to daunomycin, a DNA-damaging agent. Pharmacological inhibition of Cox-2 enhanced apoptosis in response to daunomycin, in particular in cells containing active p53. In esophageal cancer, there was a correlation between Cox-2 expression and wild-type TP53 in Barrett's esophagus (BE) and in adenocarcinoma, but not in squamous cell carcinoma (P < 0.01). These results suggest that p53 and NF-kappaB cooperate in upregulating Cox-2 expression, promoting cell survival in inflammatory precursor lesions such as BE. [less ▲]Detailed reference viewed: 35 (6 ULg)
Transcription impairment and cell migration defects in elongator-depleted cells: Implication for familial dysautonomia
Close, Pierre ; ; Cornez, Isabelle et al
in Molecular Cell (2006), 22(4), 521-531
Mutations in IKBKAP, encoding a subunit of Elongator, cause familial dysautonomia (FD), a severe neuro-developmental disease with complex clinical characteristics. Elongator was previously linked not only ... [more ▼]
Mutations in IKBKAP, encoding a subunit of Elongator, cause familial dysautonomia (FD), a severe neuro-developmental disease with complex clinical characteristics. Elongator was previously linked not only with transcriptional elongation and histone acetylation but also with other cellular processes. Here, we used RNA interference (RNAi) and fibroblasts from FD patients to identify Elongator target genes and study the role of Elongator in transcription. Strikingly, whereas Elongator is recruited to both target and nontarget genes, only target genes display histone H3 hypoacetylation and progressively lower RNAPII density through the coding region in FD cells. Interestingly, several target genes encode proteins implicated in cell motility. Indeed, characterization of IKAP/hELP1 RNAi cells, FD fibroblasts, and neuronal cell-derived cells uncovered defects in this cellular function upon Elongator depletion. These results indicate that defects in Elongator function affect transcriptional elongation of several genes and that the ensuing cell motility deficiencies may underlie the neuropathology of FD patients. [less ▲]Detailed reference viewed: 164 (29 ULg)
Raloxifene-induced myeloma cell apoptosis: a study of nuclear factor-kappaB inhibition and gene expression signature.
Olivier, Sabine ; Close, Pierre ; Castermans, Emilie et al
in Molecular Pharmacology (2006), 69(5), 1615-1623
Because multiple myeloma remains associated with a poor prognosis, novel drugs targeting specific signaling pathways are needed. The efficacy of selective estrogen receptor modulators for the treatment of ... [more ▼]
Because multiple myeloma remains associated with a poor prognosis, novel drugs targeting specific signaling pathways are needed. The efficacy of selective estrogen receptor modulators for the treatment of multiple myeloma is not well documented. In the present report, we studied the antitumor activity of raloxifene, a selective estrogen receptor modulator, on multiple myeloma cell lines. Raloxifene effects were assessed by tetrazolium salt reduction assay, cell cycle analysis, and Western blotting. Mobility shift assay, immunoprecipitation, chromatin immunoprecipitation assay, and gene expression profiling were performed to characterize the mechanisms of raloxifene-induced activity. Indeed, raloxifene, as well as tamoxifen, decreased JJN-3 and U266 myeloma cell viability and induced caspase-dependent apoptosis. Raloxifene and tamoxifen also increased the cytotoxic response to vincristine and arsenic trioxide. Moreover, raloxifene inhibited constitutive nuclear factor-kappaB (NF-kappaB) activity in myeloma cells by removing p65 from its binding sites through estrogen receptor alpha interaction with p65. It is noteworthy that microarray analysis showed that raloxifene treatment decreased the expression of known NF-kappaB-regulated genes involved in myeloma cell survival and myeloma-induced bone lesions (e.g., c-myc, mip-1alpha, hgf, pac1,...) and induced the expression of a subset of genes regulating cellular cycle (e.g., p21, gadd34, cyclin G2,...). In conclusion, raloxifene induces myeloma cell cycle arrest and apoptosis partly through NF-kappaB-dependent mechanisms. These findings also provide a transcriptional profile of raloxifene treatment on multiple myeloma cells, offering the framework for future studies of selective estrogen receptor modulators therapy in multiple myeloma. [less ▲]Detailed reference viewed: 72 (21 ULg)
Peroxisome proliferator-activated receptor-gamma1 is dephosphorylated and degraded during BAY 11-7085-induced synovial fibroblast apoptosis
Relic, Biserka ; ; et al
in Journal of Biological Chemistry (2006), 281(32), 597-604
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) plays a central role in whole body metabolism by regulating adipocyte differentiation and energy storage. Recently, however, PPAR-gamma has ... [more ▼]
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) plays a central role in whole body metabolism by regulating adipocyte differentiation and energy storage. Recently, however, PPAR-gamma has also been demonstrated to affect proliferation, differentiation, and apoptosis of different cell types. As we have previously shown that BAY 11-7085-induced synovial fibroblast apoptosis is prevented by PPAR-gamma agonist 15d-PGJ2; the expression of PPAR-gamma in these cells was studied. Both PPAR-gamma1 and PPAR-gamma2 isoforms were cloned from synovial fibroblast RNA, but only PPAR-gamma1 was detected by Western blot, showing constitutive nuclear expression. Within minutes of BAY 11-7085 treatment, a PPAR-gamma1-specific band was shifted into a form of higher mobility, suggesting dephosphorylation, as confirmed by phosphatase treatment of cell extracts. Of interest, BAY 11-7085-induced PPAR-gamma1 dephosphorylation was followed by PARP and caspase-8 cleavage as well as by PPAR-gamma1 protein degradation. PPAR-gamma1 dephosphorylation was followed by the loss of PPAR-DNA binding activity ubiquitously present in synovial fibroblast nuclear extracts. Unlike the phosphorylated form, dephosphorylated PPAR-gamma1 was found in insoluble membrane cell fraction and was not ubiquitinated before degradation. PPAR-gamma1 dephosphorylation coincided with ERK1/2 phosphorylation that accompanies BAY 11-7085-induced synovial fibroblasts apoptosis. 15d-PGJ2, PGD2, and partially UO126, down-regulated ERK1/2 phosphorylation, protected cells from BAY 11-7085-induced apoptosis, and reversed both PPAR-gamma dephosphorylation and degradation. Furthermore, PPAR-gamma antagonist BADGE induced PPAR-gamma1 degradation, ERK1/2 phosphorylation, and synovial fibroblasts apoptosis. The results presented suggest an anti-apoptotic role for PPAR-gamma1 in synovial fibroblasts. Since apoptotic marker PARP is cleaved after PPAR-gamma1 dephosphorylation but before PPAR-gamma1 degradation, dephosphorylation event might be enough to mediate BAY 11-7085-induced apoptosis in synovial fibroblasts. [less ▲]Detailed reference viewed: 20 (4 ULg)
TNFa and IKKb-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKg and NF-kB activation
; Meuwis, Marie-Alice ; Close, Pierre et al
in Biochemical Journal (2006), 394
Pro-inflammatory cytokines trigger signalling cascades leading to NF-kappaB (nuclear factor-kappaB)-dependent gene expression through IKK [IkappaB (inhibitory kappaB) kinase]-dependent phosphorylation and ... [more ▼]
Pro-inflammatory cytokines trigger signalling cascades leading to NF-kappaB (nuclear factor-kappaB)-dependent gene expression through IKK [IkappaB (inhibitory kappaB) kinase]-dependent phosphorylation and subsequent degradation of the IkappaB proteins and via induced phosphorylation of p65. These signalling pathways rely on sequentially activated kinases which are assembled by essential and non-enzymatic scaffold proteins into functional complexes. Here, we show that the pro-inflammatory cytokine TNFalpha (tumour necrosis factor alpha) promotes TANK [TRAF (TNF receptor-associated factor) family member associated NF-kappaB activator] recruitment to the IKK complex via a newly characterized C-terminal zinc finger. Moreover, we show that TANK is phosphorylated by IKKbeta upon TNFalpha stimulation and that this modification negatively regulates TANK binding to NEMO (NF-kappaB essential modulator). Interestingly, reduced TANK expression by RNA interference attenuates TNFalpha-mediated induction of a subset of NF-kappaB target genes through decreased p65 transactivation potential. Therefore the scaffold protein TANK is required for the cellular response to TNFalpha by connecting upstream signalling molecules to the IKKs and p65, and its subsequent IKKbeta-mediated phosphorylation may be a mechanism to terminate the TANK-dependent wave of NF-kappaB activation. [less ▲]Detailed reference viewed: 97 (9 ULg)
SERMs-induced myeloma cell apoptosis: A study of NF-kappa B inhibition and gene expression signature
Olivier, Sabine ; Close, Patricia ; Castermans, Emilie et al
in Journal of Bone and Mineral Research (2005, September), 20(9, Suppl. 1), 213Detailed reference viewed: 29 (5 ULg)
Low daunomycin concentrations protect colorectal cancer cells from hypoxia-induced apoptosis
Lechanteur, Chantal ; Jacobs, Nathalie ; Greimers, Roland et al
in Oncogene (2005), 24(10), 1788-1793
Hypoxia, a common feature of solid tumors, is a direct stress that triggers apoptosis in many cell types. Poor or irregular tumor vascularization also leads to a decreased drug diffusion and cancer cells ... [more ▼]
Hypoxia, a common feature of solid tumors, is a direct stress that triggers apoptosis in many cell types. Poor or irregular tumor vascularization also leads to a decreased drug diffusion and cancer cells distant from blood vessels (hypoxic cells) are exposed to low drug concentrations. In this report, we show that low daunomycin concentrations protect HCT116 colorectal cancer cells from hypoxia-induced apoptosis. While hypoxia induced p53 accumulation without expression of its responsive genes (bax and p21), daunomycin treatment restored p53 transactivation activity and cell cycle progression. We also demonstrated a role for Akt activation in daunomycin-induced protection through phosphorylation and inactivation of the Bcl-2 family proapoptotic factor Bad. Our data therefore suggest that chemotherapy could possibly, because of low concentrations in poorly vascularized tumors, protect cancer cells from hypoxia-induced cytotoxicity. [less ▲]Detailed reference viewed: 44 (12 ULg)
Phosphorylation of NF-kappa B and I kappa B proteins: implications in cancer and inflammation
Viatour, Patrick ; Merville, Marie-Paule ; Bours, Vincent et al
in Trends in Biochemical Sciences (2005), 30(1), 43-52
Nuclear factor-kappaB (NF-kappaB) is a transcription factor that has crucial roles in inflammation, immunity, cell proliferation and apoptosis. Activation of NF-kappaB mainly occurs via IkappaB kinase ... [more ▼]
Nuclear factor-kappaB (NF-kappaB) is a transcription factor that has crucial roles in inflammation, immunity, cell proliferation and apoptosis. Activation of NF-kappaB mainly occurs via IkappaB kinase (IKK)-mediated phosphorylation of inhibitory molecules, including IkappaBalpha. Optimal induction of NF-kappaB target genes also requires phosphorylation of NF-kappaB proteins, such as p65, within their transactivation domain by a variety of kinases in response to distinct stimuli. Whether, and how, phosphorylation modulates the function of other NF-kappaB and IkappaB proteins, such as B-cell lymphoma 3, remains unclear. The identification and characterization of all the kinases known to phosphorylate NF-kappaB and IkappaB proteins are described here. Because deregulation of NF-kappaB and IkappaB phosphorylations is a hallmark of chronic inflammatory diseases and cancer, newly designed drugs targeting these constitutively activated signalling pathways represent promising therapeutic tools. [less ▲]Detailed reference viewed: 53 (8 ULg)
Proteomic mass spectra classification using decision tree based ensemble methods.
Geurts, Pierre ; Fillet, Marianne ; De Seny, Dominique et al
in Bioinformatics (2005), 21(14), 3138-45
MOTIVATION: Modern mass spectrometry allows the determination of proteomic fingerprints of body fluids like serum, saliva or urine. These measurements can be used in many medical applications in order to ... [more ▼]
MOTIVATION: Modern mass spectrometry allows the determination of proteomic fingerprints of body fluids like serum, saliva or urine. These measurements can be used in many medical applications in order to diagnose the current state or predict the evolution of a disease. Recent developments in machine learning allow one to exploit such datasets, characterized by small numbers of very high-dimensional samples. RESULTS: We propose a systematic approach based on decision tree ensemble methods, which is used to automatically determine proteomic biomarkers and predictive models. The approach is validated on two datasets of surface-enhanced laser desorption/ionization time of flight measurements, for the diagnosis of rheumatoid arthritis and inflammatory bowel diseases. The results suggest that the methodology can handle a broad class of similar problems. [less ▲]Detailed reference viewed: 82 (17 ULg)
Interleukin-6 receptor shedding is enhanced by interleukin-1beta and tumor necrosis factor alpha and is partially mediated by tumor necrosis factor alpha-converting enzyme in osteoblast-like cells.
; Lambert, Cécile ; Huynen, Pascale et al
in Arthritis and Rheumatism (2005), 52(1), 84-93
OBJECTIVE: Interleukin-6 (IL-6) and soluble IL-6 receptor (sIL-6R) activation of gp130 represents an alternative pathway for osteoclast development in inflammatory conditions. The goal of the present ... [more ▼]
OBJECTIVE: Interleukin-6 (IL-6) and soluble IL-6 receptor (sIL-6R) activation of gp130 represents an alternative pathway for osteoclast development in inflammatory conditions. The goal of the present study was to investigate changes in sIL-6R levels in response to the inflammatory cytokines IL-1beta and tumor necrosis factor alpha (TNFalpha) and to determine the role of TNFalpha-converting enzyme (TACE) in this process. METHODS: Levels of sIL-6R in the culture media of MG63 and SAOS-2 osteoblast-like cell lines after exposure to various agents were determined by immunoassay. TACE protein levels were measured by Western immunoblotting. Cells were transfected with small interfering RNA (siRNA) or with an expression plasmid for IL-6R and TACE to determine the potential involvement of TACE in IL-6R shedding. RESULTS: IL-1beta and TNFalpha increased the levels of sIL-6R in the culture media of MG63 osteoblast-like cells. This effect was not influenced by cycloheximide or 5,6-dichlorobenzimidazole riboside but was markedly inhibited by the calcium chelator EGTA and by the TACE and matrix metalloproteinase inhibitor hydroxamate (Ru36156). IL-1beta and TNFalpha had no influence on the alternatively spliced form of IL-6R RNA. Levels of sIL-6R were reduced when MG63 cells were transiently transfected with TACE siRNA. Transfection of SAOS-2 cells with expression plasmids for IL-6R and TACE produced a dose-dependent increase in sIL-6R levels. CONCLUSION: IL-1beta- and TNFalpha-mediated induction of IL-6R shedding in osteoblast-like cells is at least partly dependent on TACE activation. [less ▲]Detailed reference viewed: 71 (4 ULg)
Dexamethasone inhibits the HSV-tk/ ganciclovir bystander effect in malignant glioma cells.
Robe, Pierre ; Nguyen-Khac, Minh-Tuan ; Jolois, Olivier et al
in BMC Cancer (2005), 5
BACKGROUND: HSV-tk/ ganciclovir (GCV) gene therapy has been extensively studied in the setting of brain tumors and largely relies on the bystander effect. Large studies have however failed to demonstrate ... [more ▼]
BACKGROUND: HSV-tk/ ganciclovir (GCV) gene therapy has been extensively studied in the setting of brain tumors and largely relies on the bystander effect. Large studies have however failed to demonstrate any significant benefit of this strategy in the treatment of human brain tumors. Since dexamethasone is a frequently used symptomatic treatment for malignant gliomas, its interaction with the bystander effect and the overall efficacy of HSV-TK gene therapy ought to be assessed. METHODS: Stable clones of TK-expressing U87, C6 and LN18 cells were generated and their bystander effect on wild type cells was assessed. The effects of dexamethasone on cell proliferation and sensitivity to ganciclovir were assessed with a thymidine incorporation assay and a MTT test. Gap junction mediated intercellular communication was assessed with microinjections and FACS analysis of calcein transfer. The effect of dexamethasone treatment on the sensitivity of TK-expressing to FAS-dependent apoptosis in the presence or absence of ganciclovir was assessed with an MTT test. Western blot was used to evidence the effect of dexamethasone on the expression of Cx43, CD95, CIAP2 and BclXL. RESULTS: Dexamethasone significantly reduced the bystander effect in TK-expressing C6, LN18 and U87 cells. This inhibition results from a reduction of the gap junction mediated intercellular communication of these cells (GJIC), from an inhibition of their growth and thymidine incorporation and from a modulation of the apoptotic cascade. CONCLUSION: The overall efficacy of HSV-TK gene therapy is adversely affected by dexamethasone co-treatment in vitro. Future HSV-tk/ GCV gene therapy clinical protocols for gliomas should address this interference of corticosteroid treatment. [less ▲]Detailed reference viewed: 37 (4 ULg)
Discovery of new rheumatoid arthritis biomarkers using the surface-enhanced laser desorption/ionization time-of-flight mass spectrometry ProteinChip approach.
De Seny, Dominique ; Fillet, Marianne ; Meuwis, Marie-Alice et al
in Arthritis and Rheumatism (2005), 52(12), 3801-12
OBJECTIVE: To identify serum protein biomarkers specific for rheumatoid arthritis (RA), using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) technology ... [more ▼]
OBJECTIVE: To identify serum protein biomarkers specific for rheumatoid arthritis (RA), using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) technology. METHODS: A total of 103 serum samples from patients and healthy controls were analyzed. Thirty-four of the patients had a diagnosis of RA, based on the American College of Rheumatology criteria. The inflammation control group comprised 20 patients with psoriatic arthritis (PsA), 9 with asthma, and 10 with Crohn's disease. The noninflammation control group comprised 14 patients with knee osteoarthritis and 16 healthy control subjects. Serum protein profiles were obtained by SELDI-TOF-MS and compared in order to identify new biomarkers specific for RA. Data were analyzed by a machine learning algorithm called decision tree boosting, according to different preprocessing steps. RESULTS: The most discriminative mass/charge (m/z) values serving as potential biomarkers for RA were identified on arrays for both patients with RA versus controls and patients with RA versus patients with PsA. From among several candidates, the following peaks were highlighted: m/z values of 2,924 (RA versus controls on H4 arrays), 10,832 and 11,632 (RA versus controls on CM10 arrays), 4,824 (RA versus PsA on H4 arrays), and 4,666 (RA versus PsA on CM10 arrays). Positive results of proteomic analysis were associated with positive results of the anti-cyclic citrullinated peptide test. Our observations suggested that the 10,832 peak could represent myeloid-related protein 8. CONCLUSION: SELDI-TOF-MS technology allows rapid analysis of many serum samples, and use of decision tree boosting analysis as the main statistical method allowed us to propose a pattern of protein peaks specific for RA. [less ▲]Detailed reference viewed: 75 (9 ULg)


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A blend of 50% Cabernet Sauvignon, 45% Merlot, and 5% Cabernet Franc, the 2005 Clos Marsalette offers up a sexy bouquet of roasted herbs, charcoal embers, and sweet cherries and currants. The enticing perfume is followed by a lush, voluptuously-textured, medium to full-bodied claret with superb fruit as well as purity. Drink this elegant, light on its feet offering over the next 7-8 years.
Moderately saturated medium red. Red fruits and mocha on the nose. Surprisingly supple and broad on the palate, with red fruit, game and mocha flavors complicated by sweet, soft spices. Ripe acids and sound acidity give this good balance for early drinking. With the average age of vines here just 10 years, says von Neipperg, 'we cannot push the tannins.'
Deeply coloured, dark and spiced. Touch of eucalyptus in the ripeness. Then smooth chocolatey tannins and a firm, dry but fresh finish
The item you have chosen is not in stock in our retail stores or within our main warehouse.
1997 Potensac, Médoc
1991 Labégorce, Margaux
2004 Le Plantey, Cotes-de-Castillon Bordeaux
2000 Labégorce, Margaux
1985 Soutard, St-Émilion


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Shop Owner
Coarsegold, CA, United States
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Volund's Forge Studios
I'm an independent artist working and living in the Sierra's just South of Yosemite national park. While my formal education was focused on English I made a habit of taking several art classes while obtaining by Bachelor's Degree. From an early age I have always been drawn to making and creating things… read more


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Style # R6027
A rich, coppery tone and a classic bell shape lend high style to this gold fabric lamp shade that includes a correct size harp finished in polished brass.
Spice up an existing table lamp with this colorful lamp shade. A classic bell shape with ribs in coppery gold. With a matching polished brass spider fitter. The correct size harp is included free with this shade.
Customers most agreed on the following attributes:
The shade is in my living room. It looks great.
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Article Summary
What if the concept of disabling a product after certain conditions are met wasn't just restricted to digital goods? That's the idea that a design team in Switzerland decided to explore with the "DRM Chair," a piece of furniture rigged to fall apart after being sat on eight times.
Read the full article: This chair will self-destruct in eight sits
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Enjoyed this update?
4 Comments
Interesting to see what Melvin Sokolsky could have done with this
I dont normally comment nor say bad things about fashion editorials but…. this is really really bad… those poor good clothes were put to waste… smh
I definitely preferred the normal campaign, this looks unfinished somehow


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|Table of Contents
|Vol. 4, No. 3, 2011
Issue release date: September – December
|Section title: Published: November 2011
Aleukemic Leukemia Cutis Manifesting with Disseminated Nodular Eruptions and a Plaque Preceding Acute Monocytic Leukemia: A Case ReportYonal I.a · Hindilerden F.c · Coskun R.a · Dogan O.I.b · Nalcaci M.a
aDivision of Hematology, Department of Internal Medicine, and bDepartment of Pathology, Medical Faculty, Istanbul University, and cDivision of Hematology, Department of Internal Medicine, Istanbul Bilim University, Istanbul, Turkey Corresponding Author
Yonal Ipek
İstanbul Üniversitesi İstanbul Tıp Fakültesi İç Hastalıkları ABD
Hematoloji BD, TR–34104 Fatih, Istanbul (Turkey)
Tel. +90 535 687 59 92, E-Mail email@example.com
Aleukemic leukemia cutis (ALC), a discrete tumor of leukemic cells involving the skin, may be the first manifestation of acute myeloid leukemia, preceding the onset in marrow and blood by months and years. ALC is often difficult to diagnose and is associated with a dismal prognosis. A 63-year-old male presented with nodular swellings on the face, a plaque extending over the right shoulder and multiple enlarged cervical lymph nodes. The skin biopsy of the plaque lesion showed a diffuse neoplastic infiltration extending from the dermis to subcutaneous tissue with diffuse positivity for myeloperoxidase and focal positivity for CD34 on immunohistochemical staining. The diagnosis was leukemia cutis. One month later, acute monocytic leukemia (FAB AML-M5b) was diagnosed. The patient died on the seventh month of diagnosis.
© 2011 S. Karger AG, Basel
Published online: 11/22/2011
Issue release date: September – December
Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 0
ISSN: (Print)
eISSN: 1662-6575 (Online)
For additional information: http://www.karger.com/CRO


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I've only done minor unit testing at various points in my career. Whenever I start diving into it again, it always troubles me how to prove that my tests are correct. How can I tell that there isn't a bug in my unit test? Usually I end up running the app, proving it works, then using the unit test as a sort of regression test. What is the recommended approach and/or what is the approach you take to this problem?
Edit: I also realize that you could write small, granular unit tests that would be easy to understand. However, if you assume that small, granular code is flawless and bulletproof, you could just write small, granular programs and not need unit testing.
Edit2: For the arguments "unit testing is for making sure your changes don't break anything" and "this will only happen if the test has the exact same flaw as the code", what if the test overfits? It's possible to pass both good and bad code with a bad test. My main question is what good is unit testing since if your tests can be flawed you can't really improve your confidence in your code, can't really prove your refactoring worked, and can't really prove that you met the specification?


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Police chief and hyper-protective father James drives his teenage daughter, Melanie, from their home in Chicago to a college interview in Washington, D.C. En route, they meet disturbingly cheerful parent Doug, their car breaks down and he finds his son and pet pig stowed away in the trunk. What's worse, James gets caught spying on his daughter at a sorority house. Despite the chaos, James begins to realize that his baby girl has grown up.
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Reminiscences by antiquecameoWatch
©2012-2016 antiquecameo
Amazing atmosphere.
beautiful setting...wonderful light and a gorgeous model.
so fragile and cute
beautiful fragile colours
nice ....
I love this portrait!
amazing photo
It is a very beautiful portrait !
it looks very great
I love overall concept! I think this deserves a DD!
I really love this - the composition is just awesome, everything fits together perfectly, and I like the old fashioned touch of this picture very much! Great work!
Majestic - well done
very very nice scene; lovely!
This is beautiful
Love the softness and subtlety of he colours. I wish the image was bit larger though.
Hi, your wonderful work has been featured in #VenatoresLucis's Weekly Light Hunters Feature #40, greetings!!!.
This is just beyond amazing!
I love the seeming contrast between the model and the surroundings. She's like a ghostly visitor to a forgotten place. The light adds to that illusion. It's a beautiful portrait with a very fitting title.
Beautiful shot
so pretty. such a great atmosphere
Great work!
Gosh I love this kind of picture. The texture and the vintage feel. Excellent work!
Beautiful portrait <3
this is stunning


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The JOT is distributed to 40+ countries around the globe – to all continents except Antarctica, of course! 1,200 copies of each quarterly issue are distributed to buyers, suppliers, researchers, and decision makers around the globe, and at strategic oceans-related conferences and exhibitions. Each issue has a three-month shelf life. Readers of the JOT include private sector companies; academic and research institutions, including libraries; government departments and agencies; industry regulators; and oceans-related associations and organizations.
Why advertise?
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V11N1 (Spring 2016) – The future of maritime simulation
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For advertising rates and other information, please download our brochure or send an e-mail to email@example.com.


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If you love nursing, you have come to the right site. I cannot imagine any organization I would rather be a
part of than this one. An organization laden with tradition and members who have aspired to serve the
Black community in the Greater Washington, Metropolitan Area for 40 years. If you are an RN or LPN,
come and carve out a place among us, whether it is through community service, health policy initiatives,
or our mentoring and scholarship programs. Or come with your own unique experiences and challenge us
with new ideas. If you are a student nurse or contemplating nursing as a profession, you will be in awe of
the knowledge and expertise at your fingertips... literally. You do not have to go it alone. Please take note
of our calendar ... we also have fun. And for those of you who wish to be a benefactor, we welcome your
support. Thank you for visiting our site.
Sonia Swayze, President
Black Nurses Association of Greater Washington, DC Area
Each year the Black Nurses Association of Greater Washington, DC, Area/BNA of GWDCA offers four scholarships to African American licensed nurses and student nurses who are residents of the District of Columbia and adjacent counties of the State of Maryland, namely Anne Arundel, Calvert, Charles, Howard, Montgomery & Prince Georges counties. Interested individuals may download copies of the desired scholarship application from this site. Carefully, review applications for eligibility requirements. See brief descriptions below for a listing of the scholarships and deadline dates.
The Johnella Banks Memorial Scholarship for students enrolled in a BSN, ADN or LPN program and the Felicia Brady Scholarship for licensed nurses (LPN, ADN or BSN) enrolled in an educational program for advancement to the next level of nursing education are available, annually. The deadline date for both the Banks and Brady Scholarships is January 31st of each year. Click here for the desired application.
The Margaret Pemberton Scholarship and the Founders Scholarship are available to graduating seniors of high schools located in the District of Columbia and adjacent counties of the state of Maryland (see counties listed above). The deadline date for both the Pemberton and Founders Scholarships is April 15th of each year. Click here for the desired application.
The National Black Nurses Association offers scholarships each year, see www.nbna.org for information and eligibility requirements.
Saturday, March 5, 2016
11:00 a.m. to 3:00 p.m.
Martin's Crosswinds
7400 Greenway Center Drive
Greenbelt, MD 20770
Honoring the 36th Black Nurse of the Year: Pier A. Broadnax, Ph.D., RN
Keynote Panelists:
Phyllis W. Sharps, PhD, RN, FAAN
Thelma Floyd, RN, MSN, DHA
Jocelyn Anderson, MSN, RN, FNE-A
Michelle Patch, MSN, APRN-CNS, ACNS-BC
Click image to view the Flyer
Crystal L. Scott MSN, RN-BC
Millicent Gorham,PhD, MBA, FAAN Executive Director, NBNA, Diane Deese, VITAS, Janice Johnson, BSN, RN-BC, VP, BNA of GWDCA, Beverly Morgan, RN, BN of S. Md. and others attending brunch
Mar. 28, 2015
BNA OF GWDCA Christmas Memories
BNA Volunteers


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Mr Brendan Houng
Senior Research Support Officer
Melbourne Institute of Applied Economic and Social Research
Contact details:
Phone: +61 3 8344 2086
Fax: +61 3 8344 2111
Email: email@example.com
Melbourne Institute of Applied Economic and Social Research
Level 5, Faculty of Business and Economics Building, 111 Barry Street, The University of Melbourne
Brendan Houng is a PhD candidate and Research Officer at the Melbourne Institute for the Economics of Education and Child Development program. His research focuses on the determinants of educational outcomes from both individual background and influences from the education system. In recent research he assessed the impact of attending selective high schools on university entrance outcomes, and is now investigating the effect of the allocation of high schools in rural areas on high school completion.
Selected Publications / Papers
Brendan Houng and Moshe Justman (2014): NAPLAN Scores as Predictors of Access to Higher Education in Victoria, Melbourne Institute Working Paper 22/14.
Brendan Houng and Moshe Justman (2013): Comparing Least-Squares Value-Added Analysis and Student Percentile Analysis for Evaluating Student Progress and Estimating School Effects, Melbourne Institute Working Paper 07/13.
Andre Renzaho, Mark Wooden, and Brendan Houng (2010): Associations between body mass index and health related quality of life among Australian adults. Quality of Life Research 19(4):515-520.