text:
The Issue:
Certain chemicals in cleaning products have been linked to fertility problems, birth defects, increased risk of breast cancer, asthma and respiratory disorders, and hormone disruption. What's more, there is no federal law requiring cleaning product companies to list all the ingredients in their products on the label. Which means companies can keep toxic chemicals a secret from you.
SC Johnson's GreenlistTM process, which they hold up as evidence of its product safety, still allows synthetic musks! Just how do hormone-disrupting chemicals like those even pass muster?
Did you know that some cleaning products contain hidden toxic chemicals that don't appear on labels but are linked to cancer, birth defects, fertility problems, asthma, and more? Check out these resources to keep yourself and your loved ones safe.
No Secrets Business Partners: Companies committed to increasing awareness of the links between women's health and toxic chemicals.
Dirty Secrets: Toxic chemicals testing results from top cleaning product brands.
15 Toxic Trespassers: Harmful chemicals to avoid in products women use everyday.
Green Cleaning Recipes: A few of our favorite DIY non-toxic recipes. Follow the directions or experiment a little with the ingredients to make your own!
Throw a Green Cleaning Party: Thousands of women all over the country have hosted Green Cleaning Parties – join them today!
How Did That Pine Forest Get in My Cleaner? Ever wonder how that "clean" scent ends up in your cleaning product?
Alternative to Fragranced Cleaners: Get the "clean" smell without the toxic chemicals
How-to Reduce Use of Disinfectants: Room by room advice on how to reduce exposure to disinfectants.
Disinfectants Horror Show: A fun way to introduce the issue of toxic cleaning products.
Reducing exposure during pregnancy: Tips to avoid toxic chemicals before, during and after pregnancy.


text:
Star Wars: Queen Amidala by daekazuWatch
©2013-2016 daekazu
After prequel trilogy marathon.
Sai + reference
My Tumblr >>> daekazu.tumblr.com/
My Facebook Account >>> www.facebook.com/daekazu
Sai + reference
My Tumblr >>> daekazu.tumblr.com/
My Facebook Account >>> www.facebook.com/daekazu
Very beautiful I love Padme she is my favorite💜
She's beautiful.
She's adorable. This was done perfectly.
This is perfection
i love it so much¡
Have Amidala so big eyes? xD
This is so good! :0
Make Obi-wan and Anakin with lightsabers, please!
nice work
Nice pic, but why draw such a boring character, might as well have drawn a wall with nothing on it lol
Why not? ;] I really enjoyed of her outfits.
True, but that isn't really a defining part of her character as her servant can just dress up like her and play the same part.
Also, I LOVE how you did the fur and hair, and how you did the gold decals, and the glow effect!
YAY PADME!!!! You got her perfectly! Even though she's got all this make-up and fancy Queen's robes on, drawing her with big eyes shows that underneath it all she's actually just a 14-year-old girl! Love it!
Very nice I liked that movie... even though the plot was kind of crazy
So regal!
YAH YAH YAH!!!! Please more Queen Amidala!!!!
Very cool, the color work is amazing!
Beautiful piece
ahh wow this is gorgeous! and SW fanart from one of my fave artists woo1
Reeeaally nice peace! I love the light..
very nice
Did you know Keira Knightley played Natalie Portman's double?
Love it!
Her eyes are so big
I remember watching Star Wars all the time when I was younger... This is beautiful! Great work.
that was my halloween costume in 2nd grade, love it
Wooo very beatiful
what's she looking at? XD Nice job on the clothes
Great job ♥
Totally awesome.
Very well done I love it
I Ciebie dopadło?

subset: commoncrawl


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Review: Adventure Time Puzzle Quest
Jul 27
// Chris Carter
Adventure Time Puzzle Quest (Android, iOS [reviewed])Developer: WayForward, Cartoon NetworkPublisher: D3 Go!Released: July 23, 2015MSRP: Free (with microtransactions) If you've never played a Puzzle Quest game before, the concept is fairly easy to grasp -- it's a match-three. All you have to do is switch tiles to create matches of at least three of a certain color, and you'll do a certain amount of damage to enemy forces, which you'll do battle with in an RPG-like format. That's basically it, as the series is a bit more active than a lot of other puzzlers in the same subgenre. Except with Adventure Time, a few extra cogs have been thrown into the machine to spice things up a bit. Enemy mice tiles will slowly make their way to the top of the screen, worms will periodically lower your health if they aren't dealt with, and other tiles may explode after a certain amount of time. It's up to you to manage offense and defense, alongside of your party abilities (such as Jake's taunt) to clear out your foes as quickly as possible. On paper, it actually sounds pretty cool. You'll start with Finn and Jake on a fun little adventure to rescue Ice King's drumset, and go from there to other quest-givers like Princess Bubblegum and Flame Princess. The animations for attacks are neat, especially Jake, who transforms into giant boots and jackhammers to smite baddies. But as time goes on, you'll start to understand more of how the freemium nature of the game spills into every facet of the experience, which significantly sours things. For one, combat is painfully slow. Even on the fifth mission of the game, damage starts to become woefully low, both on your side and with the enemy forces. There were times were I was doing 5% damage to one enemy with a multi-combo attack, and sometimes it takes up to 10 seconds for the matches and your attack animation to play. These aren't epic boss fights with villains like Hunson Abadeer or the Earl of Lemongrab either -- they're mere skirmishes with rats. This all plays into the in-app purchase (IAP) scheme. Multiple confusing currencies can be used to heal or revive characters (a soft energy system), buy them equipment, and buy temporary "recruits." Almost everything ties into IAP, to the point where after only an hour the game tempts you to constantly replenish your party and buy new items to make battles go faster. It's just too much, and even though there is a tournament mode that hosts different daily events, it all feels like a slog. If you've never played the series before and the concept sounds interesting, just go with the original game (which has hit multiple platforms at this point), the legion of other match-threes that spawned after it, or the superior Marvel Puzzle Quest, which is a much more respectable mobile rendition. Cartoon Network really needs to re-evaluate the developers it chooses for the Adventure Time license, because this series deserves better, and has performed poorly for far too long. [This review is based on a retail build of the free-to-play game.]
Vengeance for Orgalorg
I have a love-hate relationship with Adventure Time. In recent years, there hasn't been much in the way of consistent character development or advancement of the core plot, outside of a select few instances per season. Yet, I...
Adventure Time
Adventure Time Puzzle Quest releasing on mobile this summer
Match three in the Land of Ooo
May 19
// Darren Nakamura
Adventure Time Puzzle Quest. That really says all it needs to about what to expect. It's going to be the addictive match-three puzzling that we have been doing for years, with the familiar faces of Jake the dog and Finn the h...
Adventure Time content coming to LittleBigPlanet 3
The fun will never end with Sackboy and Friends
Apr 29
// Laura Kate Dale
Hey adventure lovers, are you looking for more content to shove into your copy of LittleBigPlanet 3? Fancy dressing Sackboy up as Finn, Jake, Fionna or the Ice King? Well, Sony is probably able to help you out there. There's...
Adventure Time
Adventure Time goes 3D in Adventure Time: Finn and Jake Investigations
For pretty much every platform
Apr 21
// Chris Carter
[Update: check out the new video showing off some early footage.] Oh hey, another Adventure Time game. Wait a minute, this one isn't a 2D homage by WayForward or a weird free-to-play mobile game? It's a legit 3D adventu...
Top 5: Trending stories
Updated every 15 minutes
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Tomm Hulett's unified Mario Timeline Theory
Mar 04
// Jonathan Holmes
If you're not in a position to look at this truly luxurious and expansive image at the moment, here are a few words from Tomm about the timeline: "This chronology begins with the Magikoopa Kamek attacking a stork carrying the Mario Brothers, causing the events of Yoshi's Island. It splits immediately, with one timeline depicting the events that follow Yoshi's rescue of Baby Luigi, and the other charting his failure. "Similar branches follow each Yoshi title to create three separate realities based on Mario's parents: Blue Collar Hero, Action Hero, and Storied Hero -- the latter of which creates two new sub-realities surrounding the babies in Partners in Time being left in the adult world: the Babies Era, where Wario and Waluigi replace the heroes, and the Adult Era, where the babies grow up to live lives of their own. Additionally, the timeline branches after Donkey Kong and any game that involves dreaming. Finally, the Action and Storied Hero timelines merge via the resolution of Mario Galaxy, leading directly to Super Mario 3D World." Brilliant stuff, Tomm. I wonder what Miyamoto and company would think of it?
The mighty multi-Marioverse explained
Game director Tomm Hulett has been working in the industry since he was a kid, starting with a job testing NES games. Since then he's worked on everything from Persona, Contra, Silent Hill, and Adventure T...
Adventure Time
Last week's Adventure Time featured Porpentine's namesake
Purple slime girls are not to be trifled with
Feb 22
// Jonathan Holmes
Popular Cartoon Network show Adventure Time is no stranger to videogame references, though these references aren't always intentional. The shout out to Super Hexegon definitely wasn't an accident, but the inclusion of a tiny ...
Adventure Time!
Here's a contest to design an Adventure Time character
For a 'soon-to-be-announced' new game
Jan 28
// Steven Hansen
If you've got drawing chops, or at least some creativity, you can see your work show up in the, "next soon-to-be-announced Adventure Time console video game" thanks to this contest from publisher Little Orbit. You have to at ...
Adventure Time Game Wizard has a pretty cool level editor
Sep 11
// Abel Girmay
So the level editor sound cool, huh? Unfortunately, the rest of the game drops the ball. Adventure Time Game Wizard is a platformer with awful controls, and a platformer with awful controls cannot carry itself very far. Out of all the different ways we've seen platformers played on a touch display, Game Wizard opts for a virtual d-pad setup. Simple commands, like switching directions, felt needlessly janky. Didn't matter whether I slid my finger over the d-pad or tapped it -- there was a noticeable pause in the time between hitting a new directional button, making the experience frustrating when going through the story mode. You can just imagine how unforgiving it can feel when playing on amateur fan-made levels. I like Adventure Time and would really dig a good game based off the show, so it hurts that this handles the way it does. Despite the rather ingenious level editor, Game Wizard is just par for the course for licensed games.
But terrible platforming
There's a new game coming out based on everybody's favorite television show, Adventure Time! You know what that means right? Go on and grab your friends, because we're going to some very distant la---actually, you might want ...
Adventure Time
Adventure Time: The Secret of the Nameless Kingdom is a shameless Zelda-like
Third times the charm?
Jul 26
// Jonathan Holmes
Adventure Time is so inherently well suited to videogames that it almost works against it. Every fan of the series already knows what they want in an Adventure Time game. Sadly, none of the game adaptations of the serie...
Adventure Time
Throw an Adventure Time Battle Party with this new MOBA
Hopefully, you can bash Lemongrab's skull in
May 19
// Brittany Vincent
I had no earthly idea there was an Adventure Time MOBA in the works, let alone a beta for one. Lo and behold, Adventure Time Battle Party's MOBA launches today with an open beta, so you can start your kids' MOBA addictions yo...
Adventure Time
Adventure Time: The Secret of the Nameless Kingdom releasing this November
Slamacow, mathematical, etc.
May 08
// Brittany Vincent
Adventure Time, that delightfully trippy Adult Swim cartoon masquerading as primetime Cartoon Network material, is receiving a brand new game in the form of Adventure Time: The Secret of the Nameless Kingdom, due out Novembe...
Adventure Time Card Wars
Adventure Time Card Wars is like Hearthstone light
And also has IAP
Feb 13
// Chris Carter
Do you remember that one episode of Adventure Time where Finn and Jake play a game called Card Wars? Well, that's a real mobile game now. It's pretty much everything you'd expect based on the rules from the show, and it ...
Contest: Win Adventure Time Collector's Edition for 3DS!
Dec 31
// mrandydixon
Five copies up for grabs
[Update: Contest over! Winners are Octorockandroll, wrathofpink, Pawel Przeslanski, wastelanderone, and Blchalifax!] I have in my grubby little hands five copies of the Adventure Time: Explore the Dungeon Because I DON'T KNOW...
Adventure Time
Ski Safari - Adventure Time is out today
It's literally Ski Safari with Finn and Jake
Dec 12
// Chris Carter
What do you get when you cross a super mathematical show with the mobile game Ski Safari? Well, Ski Safari Adventure Time would make sense, and that's just what is launching today on the Google Play and iTunes marketplaces. I...
The best and worst games of the week - Game of the Month
Nov 30
// Wesley Ruscher
Previous November Round-ups: Week ending 11/23Week ending 11/16Week ending 11/9 Stick It to the Man! (PlayStation 3 [reviewed], PS Vita)Developer: Zoink!Publisher: RipstoneRelease Date: November 19, 2013 (PS3), Early December (Vita)MSRP: $12.99 (with Cross-Buy) I enjoyed the ever-loving crap out of this game. From the cast of zany characters -- many of whom you may think are throwaways only for them to show up again in later levels -- to the crazy art style, level and puzzle design, and whimsically hilarious script. Everything is pitch-perfect. And while Stick It to the Man! isn't a particularly long title (it may only take you between three to five hours to complete the game's ten chapters) there's loads to observe and listen in on, and dozens of minds per level to explore, leaving you wanting more. I couldn't get enough of it. Read the full Stick It to the Man! review Adventure Time: Explore the Dungeon Because I Don't Know! (3DS [reviewed] PC, PS3, Wii U, Xbox 360)Developer: WayForward TechnologiesPublisher: D3 PublisherRelease Date: November 19, 2013MSRP: $29.99 (3DS), $39.99 (PC, PS3, Wii U, Xbox 360) At some point during the development process of Adventure Time: Explore the Dungeon 3DS, someone should have looked at the current build, and scrapped the project entirely. Whereas Regular Show 3DS was a flawed love letter to retro fans, Explore the Dungeon is a sheet of paper with chicken scratch scrawled on it. It's the worst game WayForward has put out in years, and yet another example of a wasted licensed game opportunity. Read the full Adventure Time: Explore the Dungeon review Borderlands 2 Headerhunter 2: The Horrible Hunger of the Ravenous Wattle Gobbler (Mac, PC, PlayStation 3, Xbox 360 [reviewed])Developer: Gearbox SoftwarePublisher: 2K GamesReleased: November 26, 2013MSRP: $2.99 After the disappointingly mediocre T.K. Baha's Bloody Harvest, I went into The Horrible Hunger of the Ravenous Wattle Gobbler with tempered expectations, but I was pleasantly surprised. Though the core gameplay is largely unchanged and the set of missions are just as short in length, Wattle Gobbler features a more fleshed out narrative, with funnier and more important dialogue. Mister Torgue shines as one of the most well-written characters in all of Pandora, and that brilliance helps make this DLC pack more worthwhile than the last one. Read the full Borderlands 2 Headerhunter 2: The Horrible Hunger of the Ravenous Wattle here Fighter Within (Xbox One)Developer: AMA, Ltd.Publisher: UbisoftRelease Date: November 22, 2013MSRP: $59.99 Fighter Within is a lazy tech demo with a poor story, unimpressive fighting engine, and a forgettable cast. Maybe one day we'll have a cool Kinect fighting game, where everyone at EVO is flailing around with some semblance of strategic value. But this is not that day. Read the full Fighter Within review Soulcalibur II HD Online (PSN, XBLA [reviewed])Developer: Project SoulPublisher: Namco BandaiRelease Date: November 20, 2013MSRP: $19.99 Soulcalibur II HD Online is a nearly flawless update of a decade old title. While it's unfortunate that the online mode isn't nearly as polished as the rest of the game, the true soul of the game has never looked so beautiful. Hopefully Namco works out the kinks in the netcode, but even with its shortcomings there is more than enough game here to warrant another go with this fighting game classic. Read the full Soulcalibur II HD Online here Mario Party: Island Tour (3DS)Developer: Nd CubePublisher: NintendoRelease Date: November 22, 2013MSRP: $39.99 The only true merit of Mario Party: Island Tour is the ability to play Mario Party with your local friends on the 3DS. As long as they have a 3DS and are close-by, playing via Download Play is fairly quick and painless. However, the lack of online play and the overall single-player experience is a pretty big bummer. Unless you're desperate and need a quick Mario Party fix on the go, stick with a console version if you can. Read the full Mario Party: Island Tour here BandFuse: Rock Legends (PlayStation 3, Xbox 360 [reviewed])Developer: Realta Entertainment GroupPublisher: Mastiff GamesRelease Date: November 19, 2013MSRP: $69.99 (Artist Pack: game + 1/4" to USB guitar cable), $79.99 (Band Pack: 2 guitar cables, mic, 4-port USB hub, acoustic guitar adapter - game NOT included), $179.99 (Guitar Bundle - Guitar Center Exclusive: game, guitar cable, & Fender Squire Bullet guitar) It's impressive to see a game such as this, focused on not only teaching you how to play guitar, but also how to have fun with it. The multiplayer extensions are a blast (if you have that many guitars, or friends that can play), and the karaoke and backing track selections can really further the creativity. While the jumps in difficulty can be drastic at the higher levels, there's still plenty of ways to adapt, and BandFuse surprises at each step. Read the full BandFuse: Rock Legends here Read the full Super Mario 3D World review
Week ending 11/30 & November Game of the Month
Thank goodness November is finally over. It was a hectic month -- that will go down in gaming history as one of the greatest ever -- thanks, in no part, to the launch of two brand spanking new consoles from both Sony and Micr...
Review: Adventure Time: Explore the Dungeon (3DS)
Nov 25
// Chris Carter
Adventure Time: Explore the Dungeon Because I Don't Know! (3DS [reviewed] PC, PS3, Wii U, Xbox 360)Developer: WayForward TechnologiesPublisher: D3 PublisherRelease Date: November 19, 2013MSRP: $29.99 (3DS), $39.99 (PC, PS3, Wii U, Xbox 360) As the name might imply, Explore the Dungeon is predictably a dungeon crawler through and through, as players are tasked with completing a randomly generated 100-floor labyrinth. There's no real plot to speak of (and that's fine), as Princess Bubblegum wants you to get to the bottom of why prisoners are escaping from said dungeon. From start to finish as either Finn, Jake, Marceline, or Cinnamon Bun (as well as a few other secret characters), you'll basically just battle your way to the end in the exact same way -- but you most likely won't make it very far. On the 3DS, the presentation is lazy, lackluster, and shameful. As a fan of retro games, I'm actually quite fond of an 8- or 16-bit style every so often, if it's done right. But here, it's clearly a placeholder for a rush-job, as the cutscenes look like they were created in Microsoft Paint, and the animation is awful all around. It doesn't help that the voice acting sounds tinny on the 3DS (like it was recorded in a parking garage) and the writing is devoid of any charm or wit whatsoever. But this lack of effort pales in comparison to the animation in-game, which renders it borderline unplayable. Simply put, the game is constantly chugging along at a snail's pace, with a perpetual framerate problem. There's no run button by default to make it better, so it feels like the entire game is running in slow motion. I honestly have no idea how the 3DS version was allowed to be released in its current condition. [embed]266260:51570:0[/embed] Gameplay isn't much better, unfortunately. It's as bare-bones as you can get. You'll have your standard attack button at your disposal (which can be charged), as well as blocking, dodging, sub-weapons, and a super power. The sad part is you won't need to mix up any of these concepts beyond mashing your normal attacks -- the AI is so poorly designed that you can get by without any sort of deviation in strategy. Although each character has a different playstyle or power (Jake and Marceline can traverse gaps, Finn can equip more items), your choice won't matter in the end because you can just breeze through the boring dungeons with any of them. While the first few floors start out promising, you'll quickly realize that each level is a ghost town, with the same few enemies repeating over and over 10 levels at a time until a new theme arises. In lieu of any sort of multiplayer found in other versions, you get a cute BMO on the bottom screen that barely talks. Foes consist of uninspired designs that vaguely resemble characters from the show, and bosses aren't that much better. The only real value the game has in terms of fan service is at the very end, where it reveals a plot point that is yet to be presented in the show. That's... literally it. The actual dungeon layouts, which tend to follow the same formula of "the staircase is always on the opposite end from where you start," are utterly uninteresting. When coupled with the boring enemy designs and the fact that you don't actually earn experience from killing anything, there's absolutely no incentive to explore in Explore the Dungeon. Speaking of experience, you have to "buy" your actual upgrades in town with the gold you acquire from the dungeon. Should you choose to go back up (you'll get the option every five floors), you better spend all the money you have -- because you lose it when you leave the hub world. It's a design choice that makes no sense whatsoever considering the game is far from "hardcore" in any other aspect. Why limit your ability to develop your character and at least have fun? Although this review is based on the 3DS game, I did get a chance to play the console version, and it's a much better experience in every respect. Not only does the game not suffer the perpetual slowdown problem of its portable cousin, but it's four players, and generally looks better all around. There are also a number of other small improvements, like the fact that Lady Rainicorn's dialog is in Korean -- small touches that show more effort. It still has the same dull gameplay as it's essentially identical in terms of feature parity, but with three other Adventure Time fanatics it could be a good bargain-bin purchase -- because it will hit the bin sooner than later. At some point during the development process of Adventure Time: Explore the Dungeon 3DS, someone should have looked at the current build, and scrapped the project entirely. Whereas Regular Show 3DS was a flawed love letter to retro fans, Explore the Dungeon is a sheet of paper with chicken scratch scrawled on it. It's the worst game WayForward has put out in years, and yet another example of a wasted licensed game opportunity.
I remember my first episode of Adventure Time. It randomly came on the TV one day and I had no idea what it was -- but I couldn't stop watching. There was something about the show that kept my eyes glued to the screen, watchi...
Adventure Time trailer
Adventure Time: Explore the Dungeon gets a launch trailer
Because I DON'T KNOW!
Nov 19
// Brett Zeidler
In case it slipped under your radars, Adventure Time: Explore the Dungeon Because I DON'T KNOW! has a quick new launch trailer to remind you that this is a thing that came out today among all the awesome stuff launching thes...
Contest: Win a cool Adventure Time watch!
Nov 11
// mrandydixon
About the watches: Nooka has partnered with Cartoon Network Enterprises again (CNE) to create a limited-edition timepiece based on Adventure Time, the fun, irreverent series from creator Pendleton Ward that has people everywhere saying things like "algebraic," "mathemagical" and "rhombus!". The Adventure Time Finn watch from Nooka features graphics and colors inspired by Finn, Jake's loveable human companion and best friend. Size: 38 x 38 x 10mmBand Width: 20mm Water Resistance: 3ATM Functions: Alarm, Chronograph, Date, Time Battery: CR2016 Battery (3.0VDC Operating Voltage) Module: 32,768Hertz Quartz Crystal Oscillation Frequency Display: TDF LCD Display Electroluminescent(EL) Case Material: Co-molded With PU Body Case Back: Stainless Steel/Screw In
Celebrate the launch of the new game
[Update: Contest over! Winners are ATBro and Swishiee!] To celebrate the impending release of Adventure Time: Explore the Dungeon Because I DON'T KNOW on November 19 (that's next week!), our friends at Cartoon Network and D3P...
Pendleton Ward Broken Age
Pendleton Ward joins the voice cast of Broken Age
Plays the part of 'the lovable Gus'
Nov 04
// Brett Zeidler
Hot off the heels of Day of the Devs, a video was posted on Double Fine's YouTube account today announcing -- and showing proof! -- that Pendleton Ward (best known as the creator of Adventure Time) will be lending his v...
Zelda, Pikmin, and Frederator cartoons coming to 3DS
Nintendo Video snags Bravest Warriors, Bee and PuppyCat
Nov 01
// Jonathan Holmes
Nintendo's dabbled in 3DS-exclusive animation before with the short-run Kid Icarus: Uprising series, and it looks like that dabbling is about to reach new heights. They're rolling out five new Nintendo Video series, starting ...
Peppermint Butler
Adventure Time Steam pre-order bonus: Peppermint Butler
Free with pre-order, $2 after the fact
Oct 15
// Steven Hansen
Still deciding which console deserves your Adventure Time: Explore the Dungeon Because I DON'T KNOW! pre-order? Aside from the 3DS-exclusive collector's edition, platform choices seemed a wash. Just pick wherever you ha...
Adventure Time ETDBIDK
Adventure Time gets more friends to explore dungeons with
About adventure time!
Oct 10
// Steven Hansen
The upcoming Adventure Time game, Explore the Dungeon Because I DON'T KNOW, got a new trailer showing off its hub world from where you can boost stats and purchase things, as well as listen to the fully voiced show character...
Adventure Time
New Adventure Time game gets 3DS-only collector's edition
Exclusive to the 3DS because I DON'T KNOW!
Aug 16
// Steven Hansen
The upcoming Adventure Time: Explore the Dungeon Because I DON'T KNOW! looks great. I enjoyed my hands-on time with the game, which has gone in a decidedly different direction from the Zelda II-styled Hey Ice King! Why'd You ...
Poke BEEMO in the face with this new Adventure Time app
It also has games!
Jul 19
// Hamza CTZ Aziz
BEEMO! IT'S BEEMO! ON YOUR PHONE-O! The lovably little computer from Adventure Time is now a free app for your iPhone and iPad! BEEMO will happily greet you upon launch, and then you can do all sorts of things with the app. P...
Adventure Time skips PS Vita, Namco trolls system fans
'Who has a PS Vita?'
Jul 18
// Jim Sterling
The new Adventure Time game is coming to Xbox 360, PS3, 3DS, and Wii U, noticeably omitting the long-suffering PlayStation Vita from its lineup. As you might expect, Vita owners are a bit upset at the snub, and have taken to ...
New Adventure Time game
Exploring Adventure Time's dungeon because I DON'T KNOW
New Adventure Time game from WayForward looking better than last year's Hey Ice King
Jul 17
// Steven Hansen
WayForward is coming with a follow-up to last year's Hey Ice King! Why'd You Steal Our Garbage?!, but it's not quite a sequel. Adventure Time: Explore the Dungeon Because I DON'T KNOW is a multiplayer dungeon crawler and, in...
Go create your very own Adventure Time game
Jul 11
// Hamza CTZ Aziz
Cartoon Network has released a free-to-play browser game where you can create your very own Adventure Time game! Adventure Time Game Creator let's you design levels, set up enemies, power-ups, and more. Right now you can only...
Adventure / Regular
Scope these Adventure Time, Regular Show game covers
Wii U and 3DS box art for the upcoming WayForward projects
Jun 24
// Tony Ponce
As you've already heard, WayForward is helming another pair of Cartoon Network games. There is Adventure Time: Explore the Dungeon Because I DON'T KNOW!, a follow-up to last year's Hey Ice King! Why'd You Steal Our Garbage?!,...
Shaqfighter, Ride A Pok�mon, The Bureau, & Metro Reviews
The Destructoid Show shuts up and JAMS
May 14
// Max Scoville
Hey gang, here's today's Destructoid Show! ...It's a weird one. Did you see those new Pokémon from Pokémon X & Y? You can ride one of them, but mostly, they just look like regular animals. If you like weird...
Adventure Time
New Adventure Time game coming, will be multi-platform
Party, party, PARTY! AWOOOOOOO!
May 14
// Tony Ponce
A GameFly listing appeared yesterday, reconfirming the existence of the upcoming Regular Show videogame. D3Publisher has put out a press release this morning officially announcing Regular Show: Mordecai and Rigby in 8-Bit Lan...
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Finding Weezer's 'Across the Sea' in Firewatch
Mastering game making with two masters of Game Maker
The biggest secret hidden across the three Assassin's Creed Chronicles games
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Status updates from everyone
Holy shit, App Store. The copyright infringement is real. I didn't buy it, because I'm scared it'll make my iPhone explode and because the comments say the game's a generic zombie title with fake and misleading screenshots.
Pretty much in a nutshell
Image of Myxococcus colony rising up after being submerged. I love bacteria so damn much you guys.
Nick R P Green
Made a quick REACTion video to some of today's news storys. Hope nobody REACTs to it with a lawsuit.
Playing Halo 5: Guardians, got REALLY invested in this one match. It was intense from beginning to end and I was using A LOT of Power Weapons because it was so fun. We were literally seconds away from victory when the internet cut off. So disappointed. :(
Amna Umen
Streaming Civ V with a few of my friends. Twitch.tv/amnaumen
I must be in a weird mood, want to buy SMS games :3
How the fuck does Link tie his scarf? I really want to wear mine that way.
As I recently mentioned I picked up Madworld, I also have acquired Pikmin, Red Steel and DJ Hero2 for Wii. For DS Feel the Magic XY/XX, N+ (shitty port I might add) Sonic Chronicles: The Dark Brotherhood, and Some Suda51 I already misplaced :/
Bought Firewatch this morning, played about 2 hours and started to get really invested into the story until I hit a bug that won't allow me to progress. :(
The Dyslexic Laywer
Fuck it. Fuck Blighttown. Fuck it's poison blow dart campers. Fuck the mosquito freaks. Fuck the fire-breathing bitches. Fuck the lack of visibility. Fuck it's pitfalls. Fuck the fact that I'm going back after 5 minutes of self-loathing.
You know what the weirdest part about having selective hemophobia is? Getting freaked out by an anime like Elfen Lied but being 100% fine with shit like this.
Nobody told me the boxed version of Revelations 2 lagged to shit. I was lucky to exchange it for Xbox money.
Nathan D
Objectively the best part of Heat.
XCom 2 is a good game that feels it needs to punish the player for not being omniscient. Still, it does have its moments. www.youtube.com/watch?v=ZXZvYRfVFuY
DTOID: I have obtained the Digimon and a Kapp'n plushie. That is all.
Pixie The Fairy
Got full Rathalos set in three tries!
Some dumb joke made for the Discord chat.
I'm still playing Tearaway Unfolded - 75% of the way to 100%. I'm gonna platnium this sucka and get my first platnium since Sly 2 back in 2012. I wrote a whole cBlog about platnium trophies and stuff a while back. 2 lazy to link it tho
I've reluctantly sauntered back to Hyperdimensia Neptunia: Rebirth 2 after a lengthy hiatus. I'm really not feeling Broccoli nor Red. Maybe Red a little more since she's a waifu protector.
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Hulk Hogan "Totally Understands" O.J. Simpson
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Jack (Jon Tenney) starts being suspiciously nice to Cybill (Cybill Shepherd) after he fires Buddy (Stephen Lee), the show's executive producer.
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Life Sciences Open Access Articles
The latest Open Access articles published in Life Sciences.
Distribution of acotiamide, an orally active acetylcholinesterase inhibitor, into the myenteric plexus of rat and dog stomachs
15 January 2016
Kazuyoshi Yoshii | Takashi Yamaguchi | Masamichi Hirayama | Ryoko Toda | Toshiko Kinomoto | Yoshihiro Kawabata | Kan Chiba
Acotiamide is the first-in-class drug for the treatment of functional dyspepsia. Although pharmacological and therapeutic actions of acotiamide are thought to be derived from its inhibitory effects...
Antifungal antibiotics modulate the pro-inflammatory cytokine production and phagocytic activity of human monocytes in an in vitro sepsis model
15 November 2015
Stefan Muenster | Christian Bode | Britta Diedrich | Sebastian Jahnert | Christina Weisheit | Folkert Steinhagen | Stilla Frede | Andreas Hoeft | Rainer Meyer | Olaf Boehm | Pascal Knuefermann | Georg Baumgarten
The incidence of secondary systemic fungal infections has sharply increased in bacterial septic patients. Antimycotics exhibit immunomodulatory properties, yet these effects are incompletely understood...
SERCA-2a is involved in the right ventricular function following myocardial infarction in rats
1 March 2015
Aurélia Araújo Fernandes | Rogério Faustino Ribeiro | Viviane G.C. de Moura | Fabiana Deise Siman | Fernanda Moura Vargas Dias | Jorge Zoghaib | Paula Frizera Vassallo | Dalton Valentim Vassallo | Ivanita Stefanon
Aerobic exercise modulation of mental stress-induced responses in cultured endothelial progenitor cells from healthy and metabolic syndrome subjects
15 February 2015
Natalia G. Rocha | Allan R.K. Sales | Renan L. Miranda | Mayra S. Silva | Jemima F.R. Silva | Bruno M. Silva | Aline A. Santos | Antonio C.L. Nóbrega
Numerous studies have demonstrated that exercise acutely prevents the reduction in flow-mediated dilation induced by mental stress in subjects with metabolic syndrome (MetS). However, it is unknown...
Behavioral tests and oxidative stress evaluation in mitochondria isolated from the brain and liver of mice treated with riparin A
15 January 2015
Geandra Batista Lima Nunes | Luciana Muratori Costa | Stanley Juan Chávez Gutierrez | Prabodh Satyal | Rivelilson Mendes de Freitas
This study aimed at evaluating the oxidative stress in mitochondria isolated from the brain and liver of mice treated with riparin A, as well as the locomotor activity and myorelaxant effect of this...
Central adenosine A1 and A2A receptors mediate the antinociceptive effects of neuropeptide S in the mouse formalin test
1 January 2015
A.D. Victor Holanda | Laila Asth | Adair R Santos | Remo Guerrini | Vanessa de P. Soares-Rachetti | Girolamo Calo' | Eunice André | Elaine C Gavioli
The present study aimed to investigate the intraplantar (ipl) and central (icv) effects of neuropeptide S (NPS) in the formalin test and to evaluate the role of adenosine receptors, mainly A1 and A2A,...
Functional heterogeneity of NADPH oxidase-mediated contractions to endothelin with vascular aging
24 November 2014
Matthias R. Meyer | Matthias Barton | Eric R. Prossnitz
Aging, a physiological process and main risk factor for cardiovascular and renal diseases, is associated with endothelial cell dysfunction partly resulting from NADPH oxidase-dependent oxidative stress....
The profibrotic role of endothelin-1: Is the door still open for the treatment of fibrotic diseases?
24 November 2014
Fernando Rodríguez-Pascual | Oscar Busnadiego | José González-Santamaría
The endothelin (ET) system consists of two G-protein-coupled receptors (ETA and ETB), three peptide ligands (ET-1, ET-2 and ET-3), and two activating peptidases (endothelin-converting enzyme-, ECE-1...
Epigallocatechin gallate attenuates ET-1-induced contraction in carotid artery from type 2 diabetic OLETF rat at chronic stage of disease
24 November 2014
Takayuki Matsumoto | Shun Watanabe | Ryusuke Kawamura | Kumiko Taguchi | Tsuneo Kobayashi
There is a growing body of evidence suggesting that epigallocatechin gallate (EGCG), a major catechin isolated from green tea, has several beneficial effects, such as anti-oxidant and anti-inflammatory...
Obesity and heterozygous endothelial overexpression of prepro-endothelin-1 modulate responsiveness of mouse main and segmental renal arteries to vasoconstrictor agents
24 November 2014
Oliver Baretella | Sookja K. Chung | Matthias Barton | Aimin Xu | Paul M. Vanhoutte
Levels of the endothelium-derived peptide endothelin-1 (ET-1) are elevated in obese humans, and ET-1 mediated vascular tone is increased. Renal arterial smooth muscle is highly responsive to ET-1. Whether...
Endothelin-1 overexpression and endothelial nitric oxide synthase knock-out induce different pathological responses in the heart of male and female mice
24 November 2014
Nicolas Vignon-Zellweger | Katharina Relle | Jan Rahnenführer | Karima Schwab | Berthold Hocher | Franz Theuring
The nitric oxide and endothelin systems are key components of a local paracrine hormone network in the heart. We previously reported that diastolic dysfunction observed in mice lacking the endothelial...
Smooth muscle specific disruption of the endothelin-A receptor in mice reduces arterial pressure, and vascular reactivity and affects vascular development
24 November 2014
Anthony J. Donato | Lisa A. Lesniewski | Deborah Stuart | Ashley E. Walker | Grant Henson | Lise Sorensen | Dean Li | Donald E. Kohan
The role of vascular smooth muscle endothelin A receptors (ETA) in development and normal physiology remains incompletely understood. To address this, mice were generated with smooth muscle-specific...
Addition of ETA receptor blockade increases renoprotection provided by renin–angiotensin system blockade in 5/6 nephrectomized Ren-2 transgenic rats
24 November 2014
Věra Čertíková Chábová | Zdenka Vernerová | Petr Kujal | Zuzana Husková | Petra Škaroupková | Vladimír Tesař | Herbert J. Kramer | Elzbieta Kompanowska-Jezierska | Agnieszka Walkowska | Janusz Sadowski | Luděk Červenka | Ivana Vaněčková
There is evidence that in addition to hypertension and hyperactivity of the renin–angiotensin system (RAS), enhanced intrarenal activity of endothelin (ET) system contributes to the pathophysiology...
Inhibition of vascular endothelial growth factor receptor under hypoxia causes severe, human-like pulmonary arterial hypertension in mice: Potential roles of interleukin-6 and endothelin
24 November 2014
Tran Van Hung | Noriaki Emoto | Nicolas Vignon-Zellweger | Kazuhiko Nakayama | Keiko Yagi | Yoko Suzuki | Ken-ichi Hirata
Severe pulmonary arterial hypertension (PAH) is an incurable disease whose exact mechanisms remain unknown. However, growing evidence highlights the role of inflammation and endothelin (ET) signaling....
Reprint of: miRNA-1 regulates endothelin-1 in diabetes
24 November 2014
Biao Feng | Yanan Cao | Shali Chen | Michael Ruiz | Subrata Chakrabarti
MicroRNAs (miRNAs) play important roles in several biological processes. In this study, we investigated the role of miR-1, an endothelin-1 (ET-1) targeting miRNA, in endothelial cells (ECs) and tissues...
Endothelin B receptor-mediated encephalopathic events in mouse sepsis model
24 November 2014
Yusuke Naito | Kento Yoshioka | Kensuke Tanaka | Koichiro Tatsumi | Sadao Kimura | Yoshitoshi Kasuya
We evaluated whether pathophysiological events in the brain in sepsis are mediated by ET-1/ETB receptor axis....
Tissue-specific and time-dependent regulation of the endothelin axis by the circadian clock protein Per1
24 November 2014
Jacob Richards | Amanda K. Welch | Sarah J. Barilovits | Sean All | Kit-Yan Cheng | Charles S. Wingo | Brian D. Cain | Michelle L. Gumz
The present study is designed to consider a role for the circadian clock protein Per1 in the regulation of the endothelin axis in mouse kidney, lung, liver and heart. Renal endothelin-1 (ET-1) is a...
Changes in biomechanical properties of the coronary artery wall contribute to maintained contractile responses to endothelin-1 in atherosclerosis
24 November 2014
Chen Yen Ooi | Michael P.F. Sutcliffe | Anthony P. Davenport | Janet J. Maguire
Our aim was to determine whether alterations in biomechanical properties of human diseased compared to normal coronary artery contribute to changes in artery responsiveness to endothelin-1 in ather...
Assessment of circulatory and pulmonary endothelin-1 levels in a lavage-induced surfactant-depleted lung injury rabbit model with repeated open endotracheal suctioning and hyperinflation
24 November 2014
Junko Kamiyama | Subrina Jesmin | Hideaki Sakuramoto | Nobutake Shimojo | Md. Majedul Islam | Tanzila Khatun | Masami Oki | Satoru Kawano | Taro Mizutani
Endothelin-1 (ET-1) is a mediator of various physiological and pathological processes, including vascular inflammation, cell proliferation and vasoconstriction. Attenuation of ET action using ET-1 antagonists...
Unexpected pulmonary hypertensive crisis after surgery for ocular malignant melanoma
24 November 2014
Kaori Sato | Tsutomu Saji | Taku Kaneko | Kei Takahashi | Kaoru Sugi
To report a case of unexpected pulmonary hypertensive crisis caused by endothelin release from melanoma cells after surgery for choroidal melanoma....
Long-term advanced therapy with bosentan improves symptoms and prevents deterioration of inoperable chronic thromboembolic pulmonary hypertension
24 November 2014
M. Nishikawa-Takahashi | S. Ueno | K. Kario
Chronic thromboembolic pulmonary hypertension (CTEPH) is a devastating disease, and treating patients with CTEPH who are not eligible for pulmonary endarterectomy is particularly challenging. Short-term...
ET-1 plasma levels, choroidal thickness and multifocal electroretinogram in retinitis pigmentosa
24 November 2014
Alessandro Finzi | Mauro Cellini | Ernesto Strobbe | Emilio C. Campos
To assess the relationship between both photoreceptor function and choroidal thickness and endothelin-1 (ET-1) plasma levels in patients with early stage retinitis pigmentosa (RP)....
Association of endothelin-1 gene polymorphisms with the clinical phenotype in primary nephrotic syndrome of children
24 November 2014
Fang Yang | Xinlong Lai | Li Deng | Xiaoxiao Liu | Jian Li | Shuixiu Zeng | Cheng Zhang | Carl-Friedrich Hocher | Berthold Hocher
This study aims to investigate the relationship between plasma endothelin-1 (ET-1) concentrations, ET-1 gene polymorphisms in loci rs5370, rs1630736, 3A/4A and clinical features of primary nephrotic...
Effect of feeding behavior on circadian regulation of endothelin expression in mouse colon
24 November 2014
Takaharu Kozakai | Mitsue Sakate | Satoshi Takizawa | Tsuyoshi Uchide | Hisato Kobayashi | Katsutaka Oishi | Norio Ishida | Kaname Saida
The function, regulation and gene expression of the endothelin (ET) system in the intestine is not well understood. We investigated the dependence on feeding schedule and biological clock of the regulation...
Potential amelioration of upregulated renal HIF-1alpha–endothelin-1 system by landiolol hydrochloride in a rat model of endotoxemia
24 November 2014
Yoshiyasu Ogura | Subrina Jesmin | Naoto Yamaguchi | Masami Oki | Nobutake Shimojo | Md. Majedul Islam | Tanzila Khatun | Junko Kamiyama | Hideaki Sakuramoto | Keiichi Hagiya | Satoru Kawano | Taro Mizutani
Endothelin (ET)-1 is the best known potent vasoconstrictor and has been implicated in pathogenesis of sepsis-associated acute kidney injury (AKI) in human or lipopolysaccharide (LPS)-induced AKI in...
Adipose-derived regenerative cell therapy inhibits the progression of monocrotaline-induced pulmonary hypertension in rats
24 November 2014
Masamichi Eguchi | Satoshi Ikeda | Saburo Kusumoto | Daisuke Sato | Yuji Koide | Hiroaki Kawano | Koji Maemura
Functional and structural changes in pulmonary vasculature characterize pulmonary arterial hypertension (PAH) and the prognosis of advanced PAH remains poor despite progress in pharmacotherapy. Adipose-derived...
Fish oil constituent eicosapentaenoic acid inhibits endothelin-induced cardiomyocyte hypertrophy via PPAR-α
24 November 2014
Nobutake Shimojo | Subrina Jesmin | Satoshi Sakai | Seiji Maeda | Takashi Miyauchi | Taro Mizutani | Kazutaka Aonuma | Satoru Kawano
A growing body of evidence shows the cardiovascular benefits of fish oil ingredients, including eicosapentaenoic acid (EPA), in humans and experimental animals. However, the effects of EPA on endothelin...
Cardiopulmonary exercise testing to evaluate the exercise capacity of patients with inoperable chronic thromboembolic pulmonary hypertension: An endothelin receptor antagonist improves the peak PETCO2
24 November 2014
Akihiro Hirashiki | Shiro Adachi | Yoshihisa Nakano | Yuji Kono | Shuzo Shimazu | Shinya Shimizu | Ryota Morimoto | Takahiro Okumura | Kyosuke Takeshita | Sumio Yamada | Toyoaki Murohara | Takahisa Kondo
The 6-min walking distance is often used for assessing the exercise capacity under the treatment with an endothelin receptor antagonist (ERA) in patients with chronic thromboembolic pulmonary hypertension...
Prognostic factors in pulmonary arterial hypertension with Dana Point group 1
24 November 2014
Shiro Adachi | Akihiro Hirashiki | Yoshihisa Nakano | Shuzo Shimazu | Toyoaki Murohara | Takahisa Kondo
To clarify the prognosis and prognostic factors in pulmonary arterial hypertension (PAH) patients in real-world medical practice in the Tokai area in Japan....
Endothelin regulates function of IL-17-producing T cell subset
24 November 2014
Kensuke Tanaka | Kento Yoshioka | Koichiro Tatsumi | Sadao Kimura | Yoshitoshi Kasuya
Although endothelin (ET) is known to play pleiotropic roles in various pathological conditions, its relation to autoimmune disease has not been elucidated. Here, we focused on interleukin (IL)-17, which...
Dual blockade of endothelin action exacerbates up-regulated VEGF angiogenic signaling in the heart of lipopolysaccharide-induced endotoxemic rat model
24 November 2014
Masami Oki | Subrina Jesmin | Md. Majedul Islam | Chishimba Nathan Mowa | Tanzila Khatun | Nobutake Shimojo | Hideaki Sakuramoto | Junko Kamiyama | Satoru Kawano | Takashi Miyauchi | Taro Mizutani
Sepsis is a cluster of heterogeneous syndromes associated with progressive endotoxemic developments, ultimately leading to damage of multiple organs, including the heart. However, the pathogenesis of...
Comparison of pharmacological activity of macitentan and bosentan in preclinical models of systemic and pulmonary hypertension
24 November 2014
Marc Iglarz | Alexandre Bossu | Daniel Wanner | Céline Bortolamiol | Markus Rey | Patrick Hess | Martine Clozel
The endothelin (ET) system is a tissular system, as the production of ET isoforms is mostly autocrine or paracrine. Macitentan is a novel dual ETA/ETB receptor antagonist with enhanced tissue distribution...
Effects of endothelin A receptor blockade in patients with ST-elevation acute coronary syndrome — A rhythmologic substudy
24 November 2014
Christopher Adlbrecht | Raphael Wurm | Thomas Pezawas | Martin Andreas | Bassam Redwan | Klaus Distelmaier | Alexandra Kaider | Irene M. Lang
Ventricular arrhythmias are common after acute myocardial infarction (AMI). Endothelin (ET) is a mediator of microvascular dysfunction and cardiac remodeling with arrhythmogenic potential. The aim of...
Endothelin receptor antagonists in clinical research — Lessons learned from preclinical and clinical kidney studies
24 November 2014
Christoph Reichetzeder | Oleg Tsuprykov | Berthold Hocher
Endothelin receptor antagonists (ETRAs) are approved for the treatment of pulmonary hypertension and scleroderma-related digital ulcers. The efforts to approve this class of drugs for renal indications,...
Endothelin-1 but not angiotensin II contributes to functional aging in murine carotid arteries
24 November 2014
Matthias R. Meyer | Natalie C. Fredette | Matthias Barton | Eric R. Prossnitz
Aging is a major risk factor for carotid artery disease and stroke. Endothelin-1 (ET-1) and angiotensin II (Ang II) are important modifiers of vascular disease, partly through increased activity of...
Calcitonin gene-related peptide protects the myocardium from ischemia induced by endothelin-1: Intravital microscopic observation and 31P-MR spectroscopic studies
24 November 2014
Satoshi Homma | Taizo Kimura | Satoshi Sakai | Ken-ichi Yanagi | Yumi Miyauchi | Kazutaka Aonuma | Takashi Miyauchi
Calcitonin gene-related peptide (CGRP) is a potent vasodilator neuropeptide. We investigated the ameliorating effect of CGRP in myocardial ischemia induced by endothelin-1 (ET-1), with special emphasis...
Selective endothelin ETA and dual ETA/ETB receptor blockade improve endothelium-dependent vasodilatation in patients with type 2 diabetes and coronary artery disease
24 November 2014
Arnar Rafnsson | Alexey Shemyakin | John Pernow
Endothelin-1 contributes to endothelial dysfunction in patients with atherosclerosis and type 2 diabetes. In healthy arteries the ETA receptor mediates the main part of the vasoconstriction induced...
The vascular endothelin system in obesity and type 2 diabetes: Pathophysiology and therapeutic implications
24 November 2014
Umberto Campia | Manfredi Tesauro | Nicola Di Daniele | Carmine Cardillo
Obesity, the metabolic syndrome (MetS), and type 2 diabetes (T2DM) are associated with heightened cardiovascular risk. Given the vasoconstrictor and proatherogenic properties of endothelin (ET)-1, increased...
Effects of vascular endothelial growth factor on endothelin-1 production by human lung microvascular endothelial cells in vitro
24 November 2014
Gregory P. Star | Michele Giovinazzo | Esther Lamoureux | David Langleben
Increased endothelin-1 (ET-1) is a hallmark of pulmonary arterial hypertension (PAH), and contributes to its pathogenesis. The factors controlling ET-1 in PAH are poorly understood. Combined with other...
Endothelin-1 regulates hypoxia-inducible factor-1α and -2α stability through prolyl hydroxylase domain 2 inhibition in human lymphatic endothelial cells
24 November 2014
Valentina Caprara | Silvia Scappa | Emirena Garrafa | Valeriana Di Castro | Laura Rosanò | Anna Bagnato | Francesca Spinella
Lymphangiogenesis, the formation of new lymphatic vessels, is thought to constitute a route for the tumor cells to metastasize. We previously demonstrated that endothelin-1 (ET-1) induces the expression...
Modulation of endothelin receptors in the failing right ventricle of the heart and vasculature of the lung in human pulmonary arterial hypertension
24 November 2014
Rhoda E. Kuc | Myrna Carlebur | Janet J. Maguire | Peiran Yang | Lu Long | Mark Toshner | Nicholas W. Morrell | Anthony P. Davenport
In pulmonary arterial hypertension (PAH), increases in endothelin-1 (ET-1) contribute to elevated pulmonary vascular resistance which ultimately causes death by right ventricular (RV) heart failure....
Urinary ET-1 excretion after exposure to radio-contrast media in diabetic patients and patients with preexisting mild impaired renal function
24 November 2014
Fabian Heunisch | Gina von Einem | Markus Alter | Andreas Weist | Thomas Dschietzig | Axel Kretschmer | Berthold Hocher
Contrast media-induced nephropathy (CIN) is associated with increased morbidity and mortality. The renal endothelin system has been associated with disease progression of various acute and chronic renal...
Late dual endothelin receptor blockade with bosentan restores impaired cerebrovascular function in diabetes
24 November 2014
Mohammed Abdelsaid | Handong Ma | Maha Coucha | Adviye Ergul
Up-regulation of the endothelin (ET) system in type-2 diabetes increases contraction and decreases relaxation in basilar artery. We showed that 1) ET-receptor antagonism prevents diabetes-mediated cerebrovascular...
Endothelin receptor antagonist exacerbates autoimmune myocarditis in mice
24 November 2014
Kazuko Tajiri | Satoshi Sakai | Taizo Kimura | Tomoko Machino-Ohtsuka | Nobuyuki Murakoshi | Dongzhu Xu | Zheng Wang | Akira Sato | Takashi Miyauchi | Kazutaka Aonuma
Myocarditis and subsequent dilated cardiomyopathy are major causes of heart failure in young adults. Experimental autoimmune myocarditis (EAM) is a mouse model of post-infectious myocarditis and inflammatory...
Serum big endothelin-1 as a clinical marker for cardiopulmonary and neoplastic diseases in dogs
24 November 2014
Shinya Fukumoto | Kiwamu Hanazono | Taku Miyasho | Yoshifumi Endo | Tsuyoshi Kadosawa | Hidetomo Iwano | Tsuyoshi Uchide
Many studies of human subjects have demonstrated the utility of assessing serum levels of endothelin-1 (ET-1) and big ET-1 as clinical biomarkers in cardiopulmonary and neoplastic diseases. In this...
Vasoprotective effects of an endothelin receptor antagonist in ovariectomized female rats
24 November 2014
Kento Kitada | Nozomi Yui | Tatsuhiko Mori | Mamoru Ohkita | Yasuo Matsumura
The effects of hormone replacement therapy with estrogen on cardiovascular disease in postmenopausal women are still controversial. In the present study, we examined the effects of an endothelin (ET)...
Endothelin B-receptors and sympathetic activation: Impact on ventricular arrhythmogenesis during acute myocardial infarction
24 November 2014
Theofilos M. Kolettis | Dimitrios L. Oikonomidis | Maria-Eleni E. Baibaki | Eleonora Barka | Marianthi Kontonika | Dimitrios G. Tsalikakis | Apostolos Papalois | Zenon S. Kyriakides
We investigated the role of endothelin-B receptors on sympathetic activation originating from the adrenal gland or from the myocardium and its impact on arrhythmogenesis during acute myocardial inf...
Long-term patient survival with idiopathic/heritable pulmonary arterial hypertension treated at a single center in Japan
24 November 2014
Aiko Ogawa | Kentaro Ejiri | Hiromi Matsubara
Idiopathic/heritable pulmonary arterial hypertension (I/HPAH) carries a poor prognosis despite the therapeutic options available. Patient survival from Western countries has been reported, but data...
β-Arrestin 1 is required for endothelin-1-induced NF-κB activation in ovarian cancer cells
24 November 2014
Roberta Cianfrocca | Piera Tocci | Elisa Semprucci | Francesca Spinella | Valeriana Di Castro | Anna Bagnato | Laura Rosanò
In epithelial ovarian cancer (EOC), activation of endothelin-1 (ET-1)/endothelin A receptor (ETAR) signalling is linked to many tumor promoting effects, such as proliferation, angiogenesis, invasion...
Dual endothelin receptor antagonism with bosentan reverses established vascular remodeling and dysfunctional angiogenesis in diabetic rats: Relevance to glycemic control
24 November 2014
Mohammed Abdelsaid | Jessica Kaczmarek | Maha Coucha | Adviye Ergul
We have shown that diabetes causes cerebrovascular remodeling in part by the activation of the endothelin (ET-1) system in a glucose-dependent manner. We also reported increased yet dysfunctional cerebral...


text:
Welcome to the Coalmarch blog, where we write about website design, programming, Drupal, Adobe Photoshop, how not to get run over by a downtown Raleigh bus, and much, much more.
Thanks for stopping by, feel free to share your opinion if you are feeling adventurous!
Think back on all the content you could have read today. How many blog posts and articles did you scroll past on your Facebook newsfeed this morning? How many links did you thumb through on Twitter while you waited for your coffee? How many Google results did you hover over before picking one? I'm willing to bet that the meta-description played a... read more
My journey to Coalmarch is probably a little unorthodox. Until this last October, I was a public school Health and Physical Education teacher for fifteen years. Sure, all-day P.E. probably sounds pretty fun, but a man can only play so much dodgeball! Truthfully, teaching served me well for many years, but I felt like something was missing. My... read more
In November, I attended SassConf with Ryan Scotton in Austin, TX. In between gorging ourselves on delicious Tex-Mex, I kept hearing about gulp.js. On all of our projects at that time, we had been using guard to compile our Sass. Sure, it worked, but it sounded like gulp was a whole lot faster. Note: this article assumes you are at least somewhat... read more
We use the "IMPORT RANGE" function in Google Sheets frequently. It's crucial when trying to work with the behemoth of admin documents we have. Luckily, it's a pretty straightforward function. All it does is pull in a cell from another sheet into the sheet we're working in. But, there's one problem with it: if you're working with a... read more
This past month, several members of the Coalmarch crew spent a few days soaking up everything that Internet Summit had to offer. We made a game plan, split up, and attended educational sessions on everything from user experience to content marketing. For the purpose of this post, we'll focus on content marketing– specifically, Arnie Kuenn's pre-... read more


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Funding via CrediCampo
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Heydi Azucena
El Salvador
Funding via Apoyo Integral
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Dora Alicia
Ciudad Barrios, El Salvador
Food Production/Sales
Loan Overview
Repayment Schedule
Loan Updates
Dora is 44 years old, she is a single mother of two children aged 12 and 7 and she has been engaged in retailing for 7 years, putting all her efforts in her job in order to provided her children with the daily bread. For five years she has prepared tortillas in the morning and "pupusas" (a typical Salvadorian dish) in the afternoon to then sell them. These days she is selling French fries. Dora has had to work very hard since her husband left her. She buys the ingredients she needs to prepare French fires in the village market, transposition them with a moto taxi to cover the two kilometers from the market to her house.
The loan she is requesting to Fundación Campo will be used to buy potatoes, sauces, mayonnaise, reusable dishes, firewood and gas, as well as to finish paying off for the small wagon where she fries potatoes. She hopes to succeed in increasing her earnings thanks to the loan, in order to always have food for her children, as she says there have been times when they did not have anything to eat and she does not want to find herself in this situation again. She also wants to buy a fridge to store food for her family, and she wants to make improvements to her house making it bigger and with better structure.
Translated from Spanish
Kiva Volunteer
Emanuela Villa
View original language description ↓
Dora tiene 44 años de edad, es madre soltera de dos hijos, uno de 12 años y otra de 7 años de edad. Ella se dedica desde hace 7 años al comercio, ha trabajo y se ha esforzado para que a sus hijos no les falte la comida. Durante cinco años elaboro tortillas por la mañana y por la tarde elaboraba pupusas para la venta. Actualmente, vende papitas fritas; Dora ha tenido que trabajar mucho ya que su esposo la abandono. Los insumos para preparar las papitas fritas, las compra en el mercado del pueblo y las transporta en una mototaxi hasta su casa que esta a dos kilómetros.
El préstamo que esta solicitando a Fundación Campo, es para comprar papas, salsas, mayonesa, platos descartables, palillos de madera, gas y el resto para terminar de cancelar el carretón en donde fríe las papitas. Con la inversión, espera incrementar sus ingresos, para que a sus hijos no les falte el alimento, ya que comenta que ha habido ocasiones en que no han tenido que comer y ella no desea pasar por esa situación otra vez. También, desea comprar un refrigerador para almacenar la comida de su familia, mejorar la vivienda hacerla más grande y mejorar la infraestructura.
Additional Information
About CrediCampo
This loan is administered by CrediCampo, a Kiva Field Partner in El Salvador. CrediCampo seeks to improve the lives of rural communities and their families in areas including health, education, basic services, and infrastructure. Through its Community Development Unit, CrediCampo provides scholarships, leadership development training, and financial education programs for families in rural areas. CrediCampo's work is crucial in addressing the issue of poverty in El Salvador. Based on 2009 estimates, 37.8% of the population lives below the poverty line. To learn more about CrediCampo and their work, visit their
partner page
About El Salvador
Average annual income
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El Salvador Loans Fundraising
Funds lent in using Kiva
US Dollars
Loan transacted in USD
Success!! The loan was 100% repaid
A loan of $300 helped Dora Alicia to buy potatoes, sauces, mayonnaise, reusable dishes, firewood and gas, as well as to finish paying off for her small wagon.
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Repayment Term
9 months
(Additional Information)
Repayment Schedule
Nov 28, 2012
Jan 1, 2013
Currency Exchange Loss:
Dec 17, 2013


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Nastya A II by Daria Zaytseva by daria-zaytsevaWatch
©2011-2016 daria-zaytseva
Photography: Daria Zaytseva / www.DariaZaytseva.com
Model: Nastya
MUA: Victoria Fernanda
Style: Kate B
Model: Nastya
MUA: Victoria Fernanda
Style: Kate B
i love it, she's gorgeous
I've been in love!
I love your work!!
I love your work!!
Beautiful job!
I love all the portraits!
luv this 1 lol...simply stunning
I love how the photo makes you look right at her juicy red lips. Sexy without trying.
| woooooooooooow
sooo buety
sooo buety


text:
We are recruiting members for PS3 GHOST, the current clan will not be making the transition to PS4. We play tactically and have great communication skills to ensure victory playing mostly core objective based games. For black ops II we took part in clan ops, daily/weekly challenges including zombies, my favorite clan battles, and hosted clan tournaments. We send out messages informing the clan of what is happening for the week and how everyone performed during each of those events. We also have a dedicated clan facebook and will have a youtube channel and webpage up and running within the next week. We are smaller than some clans having roughly 15 active members after losing over half from the PS4/GHOST transition. For those of you that do not already know GHOST is focused a lot on clan activities making it really fun to be in a clan. They will have two week clan competitions matching you against 7 other clans in similar size and skill that you will compete against for the two weeks starting the 25th of November. We can also compete against other clans 4v4 rather than random COD players. In addition certain equipment can only be unlocked by clan challenges. If you would like to join you can send a message to BEASTMODE_207 on PSN. All of our members are actively playing at least 5 if not 7 days of the week. I am the leader currently ranked around 15,000 in the world overall, 3rd prestige, and ranked a couple hundred in the world in certain game modes.
Have a mic!!! (use your mic)
a passion for the game
play with the CLAN


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Posts from September 2013
Howdy !!!
by Rick Frischman
posted Sep 24 2013 7:47AM
Back we are for more notes from "the afternoon dude"!! At 98Q Country, we can pass the gas with the best of'em! Yes, pass the gas (cards) onto you, our awesome listeners. Listen for our bell sound effects, be caller #9, and you're one of the qualifers for our weekly $98 gas card. I guess it does pay to listen to 98Q. Have fun with that!!
On a totally unrelated note, the leaves are starting to turn, the glow of lights are seen Friday nights surrounding area high school football fields, and signs point to the end of summer
. And what a rotten summer it was!! It actually got here about a month late. This was probably the worst summer in the last ten years. Hopefully we'll get a bit of the Indian Summer down the line.
Enjoy life in Wisconsin's beautiful northwoods....I'll talk to ya on the radio!!!
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by Rick Frischman
posted Sep 9 2013 12:38PM
Greetings once again, DJ Rick penning a few notes from my plush, state of the art studio. The last two weekends I had the privledge to get out for "remote" activities. Last Friday it was the Neon Glow Fun Run at the Prentice Pines Golf Course, and Saturday was our 2nd annual Flambeau Hospital/98Q Country Senior Health & Leisure Expo at the Phillips Municipal Building. It's always great to meet our listeners, who sometimes say they like putting a face to the voice.
In other weekend news, the Packers lose (which we all figured), but the Cheguamegon Football team rolls in Rib Lake and the Badgers once again crush a less than top notch opponent. The outcome not so good for the Loggers who get beat for the 3rd time w/o a victory in the young season. Take Care....I'll talk to you on the radio.
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We were in transit from Mexico airport to Oaxaca, and location in front of CAPU (main Puebla bus station) was ideal. Facilities are good for the location. The staff was outstanding: one of us was sick, and the airline left one bag in Miami. Araceli, a member of the staff, called the airline repeatedly until the bag was delivered. A... More
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This fundraising event is being held to raise awareness for mental health and addiction disorders, and to help combat the stigma that is faced by those who suffer with mental illness. This family-friendly event will feature entertainment, food, and fun. There will also be a doggie oasis for those families who wish to bring their dog.
free, donations welcome
Carrier Clinic
Donna Zaleski
all ages
Registration suggested
We make every effort to ensure the accuracy of this information. However, you should always call ahead to confirm dates, times, location, and other information.


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Connect With Us800-299-9470
Fun-loving little ones will adore gathering around the Alphabet Soup Table and Chair Set! The bright colors, fun patterns and "Alphabet Trail" game will stimulate their learning experience, while providing hours of entertainment. Also, it's designed to match CoCaLo's Alphabet Soup Crib Bedding Collection.
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Looking for beef recipes? Our collection of beef recipes is infused with flavorful main dishes for every season: Grilled steaks, flank steak dishes, beef stews, chili recipes, pot roasts, ground beef dishes, and lean beef recipes for health-conscious meals.
Pho (Beef Noodle Soup)
Just before serving, add a nest of rice noodles and razor-thin slices of beef to the fragrant hot broth.
Blackened Flank Steak
Use blackened flank steak to make a wonderful black and blue salad. Toss mixed salad greens with blue cheese crumbles or blue cheese salad dressing in a salad bowl. Top with the sliced steak. Makes a beautiful presentation and is a treat for the taste buds.
Honey and Ginger Marinated Flank Steak
Marinate your steak in the morning in this honey and ginger sauce and it's ready for the grill when you get home from work.
Guacamole Burger
There is something so satisfying about just a tablespoon of creamy guacamole on a burger.
Roast Beef with Sweet Red Pepper Vinaigrette
A red pepper vinaigrette spices up traditional roast beef.
Ground Beef Baked in Acorn Squash
A medley of fall flavors, beef and squash blend beautifully with autumn spices like allspice and cloves in this beef recipe
Thai Lettuce Wraps with Cilantro
Ground beef, flavored with mint, cilantro and red pepper, is wrapped in leaves of cabbage or romaine.
Sesame-Ginger Steak Stir-Fry
Give some steak and vegetables a quick dance in the skillet or wok for a lovely stir-fried dinner.


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Monday, September 1, 2008
Monday, September 1, 2008
From The Editor: The Call Of Technology
The changing face of aviation
|The market for new general aviation airplanes seems to be changing. Today's new airplane buyer has different needs, goals and experience. To pinpoint this psychographic, Marc C. Lee spoke with sales representatives from various aircraft manufacturers, and it's clear that there has been a shift in who's buying what, and why.


text:
Tack For Sale Show & Western
(a) Full size light oil complete bridal. Texas stars w/ sliver studs headstall, butterfly bit and 7 ft long double thick harness split reins. Never used & Perfect shape. All brand name. Email for pics. Make cash offer. Willing to ship if buyer is willing to pay.
(B) Two matching light fusion pink full size headstalls & barrel reins. Made by Weaver & in perfect shape. No bits. Both come with chin straps. Email for pics. Willing to ship if buyers pays. Make offer on both or each set alone.
(C) Complete light oil western show set-less bit. Light oil, full size, used twice, brand name & lots of good real sliver. Headstall- Split reins and breast straps. A must see. In perfect shape. Email for pics. Make fair offer.
Email for pics of listed tack- Open to package deals!
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Winston Churchill bust by TomasKralWatch
©2012-2016 TomasKral
This is a caricature of Sir. Winston Churchill displaying him as a bust just standing on his place, minding his own business, while he is cruelly attacked by a pigeons.
Daily DeviationGiven 2013-04-19
Winston Churchill bust by ~TomasKral ( Suggested by keyan3d and Featured by alltheoriginalnames )
Love it
do you have this in higher resolution???
It took me quite a while to figure out this wasn't a photo... But really, this isn't a photo!? How in the... It looks so real!
Dude, that is INSANE. Wow.
wait this isn't a photo of an amazing sculpture
I almost can't believe it.
I almost can't believe it.
just wow
Wow, very nice! Congrats on the DD!
This is not a photo this is not a photo this is not a photo this is not a photo this is not a photo SINK IN GODDAMN IT! Amazing work!!
While he is cruelly attacked by a pigeon.
poor bust.
woow nice
"We will defend our island, whatever the cost..."
Pigeons are nasty creatures. I do not like them and often chase them in the town square. People think I am retarded (being 22 y.o.) but I just do not like those birds.
Aww, don't hate 'em, they're sweet creatures! ^-^
Well I must say, that IS pretty retarded.
All best statues have poo on them
Love the picture its really cool
Lol, pigeons don't care if it's a statue of a famous, important person, they just like to poop wherever they happen to be sitting
Congrats on the DD
Congrats on the DD
- Congrats on the well deserved DD!
Have a nice day!
That... pigeon... Ha.
Excellently done.
Excellently done.
this is awesome dude
Oh damn!
Seen Night at the Museum 2? Imagine the second Teddy Roosevelt, but with this.
Seen Night at the Museum 2? Imagine the second Teddy Roosevelt, but with this.
looks like warden from superjail xD
love that. havent seen 3d art in such a creative context for ages!
the colors are amazing
haha awesome
Congrats on the Daily Deviation!
This is brilliant! Yep brilliant indeed!
Great job on the bronze effect too, I thought it was real until I looked closer at the bird and read the description
Wow that bust is not so flattering! But I love it because his expression suits the situation perfectly.
awesome sculpt and I love the way you've compose the scene
funny with the bird on his hat
funny with the bird on his hat
There's just something about this that is really awesome.