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March 11, 1992
March 4, 2013 9:04 PM EST
in the topic
Search for voip
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Business planning
Voice over Internet Protocol (VoIP) has brought sweeping changes to the telecommunications industry. Consumers have used services such as Vonage and Skype to lower telephone bills and connect with loved ones around the world. Businesses have reaped far greater benefits from VoIP when they have installed IP enabled telephone systems and Hosted PBX services.For this services and all we need Voice Quality.Its Very Important in VOIP and PBX Hosted Services is Voice Quality.Without Voice Quality we can't do anything.The Total services and Technology will be waste. VOIP Services in Telephony Your Way
February 18, 2013 6:44 PM EST
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Best Customer Service Practices
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Customer Service & Customer Experience
As all Said Customer Practices is very important.Today the Competition is fierce, and customers have more options than ever.Its a tough combination for smaller companies trying to gain more profits in society and among their competitors. Someone will say Customer is the King.So all the Entrepreneurs can gather so many Informations from their Customers whether they may be small or large business holders. In my Business i was always concentrate on the best customer skills: Strategic Preparation Awareness Active Listening Empathy Problem Solving. For my all VOIP services providers and customers i will give the Quality and Best Services to them and also for their small business services. Telephony Your way
February 6, 2013 9:18 PM EST
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Efficient Phone Systems -What to do?
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Strategies & Tactics for Getting Efficient
Ya Hosted PBX Will be best options for all Small Business Phone System. Telephony Your Way will Provide you Smart and Cheap Hosted pbx Provider. Top Hosted pbx Providers
February 6, 2013 9:12 PM EST
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Virtual Phone System fo Small Businesses
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Strategies & Tactics for Getting Efficient
If You use Virtual System for Your Small Business Phone System You can get so many benefits. I have listed some of the benefits: Keep your existing phone numbers - no transfer fees Connect multiple office locations Auto-receptionist with multiple virtual extensions Reliable Phone and fax service Integrate mobile or remote employees Implementation advisors to help get you setup, at no cost 24/7 free Customer Support No Setup fees, no contracts required Virtual pbx Prices
February 6, 2013 5:49 PM EST
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Everything we missed with the other categories
A hosted PBX System will connect Multiple offices, Remote employees and even mobile workers with one system.It has the Highest Reliability and also no matter the size of the company.You can maintain the small business Phone System with very low price to maintain your Business.All facilities like call routing and simple administration.Easily set up and customize your system in few minutes. Telephony Your Way will Provide you all Facilities with all details and Customer Requirements Top Hosted pbx Providers
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Private High Schools in Kettering
Which schools are assigned to my home?
About Kettering Schools
Kettering contains 1 primary and secondary schools.
School Districts Near Kettering
Disclaimer: School attendance zone boundaries are supplied by Maponics and are subject to change. Check with the applicable school district prior to making a decision based on these boundaries.

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Sep 6
Aug 9
Mar 2
Trinity Episcopal's Country Mass. Celebrating the music of Hank Williams.
Feb 13
Troubadour Thursdays
Jan 30
Troubadour Thursdays
Label: Zero Label Records
Bio: Leslie Anne Sloan, aka Miss Leslie, was born in Charleston, SC to parents of distinctly different musical tastes. Her father was a church minister from Tennessee who loved bluegrass and classic country. Her mother grew up in Florida and played classical piano. At the age of 5, after the family...See Full Bio
"Houston isn't exactly honky-tonk heaven, but the sorrowful lyrics and steely solos of fiddle-playing frontwoman Miss Leslie and her band will have you thinking otherwise. Leslie's gift for turning pain (she's a recent divorcee) into country gold marks her as a kindred spirit to fellow heartbroken Southeast Texan George Jones. For proof, check out the recent Between the Whiskey and the Wine."


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Sandra Crouch
|Sandra Crouch
July 1, 1942
San Francisco, California
|Light Records
Sandra Crouch (born July 1, 1942) is an American Gospel music performer, drummer and songwriter.
Musical career[edit]
Crouch won a Grammy Award in 1985 for "Best Soul Gospel Performance, Female". During the late 1960s through the early 1970s, she played tambourine on a number of Motown recording sessions.
Personal life[edit]
Crouch was born on July 1, 1942 in San Francisco, California along with her twin brother Andraé.[1] Until his death in January 2015, she and her brother co-pastored Christ Memorial Church of God in Christ in Pacoima, California.[2] On the day of her brother's death, Crouch released the following statement: "Today my twin brother, womb-mate and best friend went home to be with the Lord. Please keep me, my family and our church family in your prayers. I tried to keep him here but God loved him best."[3]
- Gospel Legacy, 2008
- With All Of My Heart, 1992
- We're Waiting For You, 1985
- We Sing Praises, 1983
With Lalo Schifrin
- Rock Requiem (Verve, 1971)
- ^ Rober Jablon. "Andrae Crouch Obituary". The Associated Press. Retrieved April 5, 2015.
- ^ "Our Pastors". New Christ Memorial Church of God in Christ. Retrieved January 10, 2015.
- ^ "Legendary Gospel Artist Andrae Crouch Dies at 72". KTLA 5. January 8, 2015. Retrieved January 8, 2015.
|This gospel music article is a stub. You can help Wikipedia by expanding it.
- 1942 births
- American gospel singers
- Living people
- Grammy Award winners
- American Christians
- American Pentecostals
- Members of the Church of God in Christ
- Church of God in Christ pastors
- Singers from San Francisco, California
- Drummers from San Francisco, California
- Songwriters from San Francisco, California
- Gospel music stubs


text:
Very nice composition!LK.
Saluti dalla Toscana.
I just wanted to let you know that I have made this photo the current avatar for the Automobile Group. It is a very good representation of photos for this group.
Happy New Year, Larry
Thanks for the honour, Larry!
Happy New Year 2u2!
Sus vehiculos muy nice... Excelente
Wow,great shot!!!
oskar, muchas gracias por su visita y las palabras gentiles!
Jutka, thank you very much for your visit and all the kind comments!
Interesting photo. LIKE. Jgiondla
Photo taken in Havana, Cuba
Malecón (El)


text:
Advertising in the
Social Marketing Mix:
Getting the Balance Right
Martine Stead Gerard Hastings University of Strathclyde, Glasgow
Social marketing continues to be equated, by many practitioners and even by some academics, with social advertising. Overstating advertising's importance in social marketing threatens the discipline in several ways: Nonpromotional elements of the social marketing mix are neglected, social marketing is restricted in practice, distracting arguments are generated, social marketing is blamed for advertising's limitations and is subject to ethical misgivings. Some have argued that the dominance of social advertising in social marketing is inevitable because the intangibility and immutability of social marketing's products leave promotion as the only mix variable open to manipulation. However, social marketers can change their products, as a UK social marketing initiative promoting water fluoridation to the public, policymakers, and the media demonstrates. Creative thinking is needed to prevent social marketers believing that all they can change is promotion and all they can do is social advertising.
From the early days of social marketing, theorists and practitioners have cautioned that social marketing "is a much larger idea than social advertising" ( Kotler & Zaltman, 1971, p. 5) and encompasses more than the design and use of mass media campaigns ( Kotler, 1994; Sutton, 1991; Young, 1988-1989). Yet, the tendency to label what is essentially social advertising activity as social marketing persists at practitioner level, as Andreasen ( 1994) noted: "Too many practitioners are really doing social advertising and calling it social marketing" (p. 9). Papers and textbooks continue to be written that, by citing mass media advertising campaigns


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Are you Sepp Seifert?Claim your profile
Publications (56)103.29 Total impact
Article: ChemInform Abstract: TROTEC-1: A New High-Affinity Ligand for Labeling of the Dopamine Transporter[Show abstract] [Hide abstract]
ABSTRACT: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option.ChemInform 03/2010; 30(12). DOI:10.1002/chin.199912187
Article: Very stable 188Re-S4 chelates for labelling biomolecules: preparation with highly concentrated perrhenate eluates.[Show abstract] [Hide abstract]
ABSTRACT: The preparation and stability of a new (188)Re-S(4)-complex [S(4) = (1-aza-18-crown-6)(O)C-C(SH)-C(SH)-C(O)NH-(CH(2))(3)-NH-(CH(2))(3)-NHC(O)-C(SH)-C(SH)-C(O)(1-aza-18-crown-6] was studied at therapeutic relevant radioactive concentrations. The results were compared with (188)Re-MAG(3) (MAG(3): mercaptoacetyltriglycine) and (188)Re-DMSA preparations (DMSA: dimercaptosuccinic acid) performed with the same highly concentrated [(188)Re]perrhenate solution (12-15 GBq/ml). The (188)Re complexes were prepared by direct reduction of perrhenate ((188)Re-S(4)-complex) as well as via the (188)Re-EDTA precursor complex ((188)Re-MAG(3), (188)Re-DMSA). The preparations were stabilised with 15 mg of ascorbic acid and analysed after 1, 2, and 24 hours by TLC and HPLC. Additionally, in vitro and in vivo stability studies were performed with the purified complexes. After stabilisation with 15 mg of ascorbic acid, all of the complexes were nearly stable under nitrogen for hours, and only 2-8% of perrhenate was observed after 24 h. In contrast, only the (188)Re-S(4) complex was completely stable in vitro and in all investigated in vivo samples after separation of ligand excess and reducing agent by HPLC. The bridging amine group or free carboxylic groups of the S(4)-ligand framework make available reactive positions for coupling biomolecules to the chelate. Thus it appears that the new (188)Re-S(4) complexes offer the possibility of stable and high specific activity labelling of biomolecules for therapeutic application.Nuklearmedizin 02/2007; 46(5):181-4. · 1.49 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Aim: The preparation and stability of a new Re-188-S-4-com- plex [S-4 = (1 -aza-18-crown-6)(O)C-C(SH)-C(SH)-C(O)NH-(CH2)(3)-NH-(CH2)(3)-NHC(O)-C(SH)-C(SH)- C(O)(1 -aza-18-crown-6] was studied at therapeutic relevant radioactive concentrations. The results were compared with Re-188-MAG(3) (MAG(3): mercaptoacetyltriglycine) and Re-188-DMSA preparations (DMSA: dimercaptosuccinic acid) performed with the same highly concentrated [Re-188]perrhenate solution (12-15 GBq/ml). Methods: The Re-188 complexes were prepared by direct reduction of perrhenate (Re-188-S-4-complex) as well as via the Re-188-EDTA precursor complex (Re-188-MAG(3), Re-188-DMSA). The preparations were stabilised with 15 mg of ascorbic acid and analysed after 1, 2, and 24 hours by TLC and HPLC. Additionally, in vitro and in vivo stability studies were performed with the purified complexes. Results: After stabilisation with 15 mg of ascorbic acid, all of the complexes were nearly stable under nitrogen for hours, and only 2-8 % of perrhenate was observed after 24 h. In contrast, only the Re-188-S-4 complex was completely stable in vitro and in all investigated in vivo samples after separation of ligand excess and reducing agent by HPLC. Conclusion: The bridging amine group or free carboxylic groups of the S-4-ligand framework make available reactive positions for coupling biomolecules to the chelate. Thus it appears that the new Re-188-S-4 complexes offer the possibility of stable and high specific activity labelling of biomolecules for therapeutic application.Nuklearmedizin 01/2007; 46(5). DOI:10.1160/nukmed-0082 · 1.49 Impact Factor
Article: Preparation and Biological Characterization of Isomeric 188 Re(V) Oxocomplexes with Tetradentate S 4 Ligands Derived from meso -Dimercaptosuccinic Acid for Labeling of Biomolecules[Show abstract] [Hide abstract]
ABSTRACT: A new type of tetradentate S4 ligand has been synthesized by bridging two molecules of meso-2,3-dimercaptosuccinic acid for stable binding and easy conjugation of rhenium-188 to tumor targeting structures. The stereoisomeric tetrathiolato S4 ligands form very robust anionic five-coordinated oxorhenium(V) and oxotechnetium(V) complexes. Two routes for the preparation of the (188)Re(V) oxocomplexes with (iBu)2N(O)C-C(SH)C(SH)C(O)NH(CH2)3NH(CH2)3NHC(O)C(SH)C(SH)C(O)N(iBu)2 (ligand 1) and its hydrophilic crown ether derivative (ligand 2) were tested and optimized. Several isomers were separated by HPLC from the preparation solutions and characterized in vitro and in vivo. The identity of the species obtained was determined by comparison with the HPLC profiles of reference (185/187)Re analogues and (99/99m)Tc complexes which were characterized by ESI-MS. All of them were absolutely stable in rat and human plasma solutions. Challenge experiments with cysteine corroborated the high inertness of the isomers toward ligand exchange reactions. Various in vivo samples, taken off at different times from blood, intestine, and urine of rats, confirmed the high in vivo stability of the (188)Re-S4 complexes. Biodistribution studies using male Wistar rats were performed and exhibited a high uptake and fast clearance from the liver of the more lipophilic cis and trans isomers of complex I (log P(o/w) between 1.5 and 1.7), whereas the isomers of the hydrophilic complex II (log P(o/w) about -1.75) were rapidly excreted via the renal and the hepatobiliary pathway. The low level of activity in the stomach confirms good in vivo stability. Thus, these new (188)Re-S4 complexes fulfill the requirements for a stable and high specific activity labeling of biomolecules with rhenium-188.Bioconjugate Chemistry 11/2006; 17(6):1601-6. DOI:10.1021/bc0602331 · 4.51 Impact Factor
Article: The 188Re(III)-EDTA complex - A multipurpose starting material for the preparation of relevant 188Re complexes under mild conditions[Show abstract] [Hide abstract]
ABSTRACT: An easy and gentle method for the preparation of 188Re(V) complexes with bidentate and tetradentate ligands is described starting from the precursor complex 188Re(III)-EDTA. That complex is prepared at room temperature in acidic solution and reacts by a combined re-oxidation/ligand exchange reaction with appropriate ligands like DMSA or ECD (DMSA = dimercapto succinic acid, ECD = L,L-ethylene dicysteine diethyl ester) or en, tau, and cyclam (en = ethylene diamine, tau = 1,4,8,11-tetraazaundecane, cyclam = 1,4,8,11-tetraazacyclo-tetradecane) to the 188Re(V)-oxo- and dioxocomplexes, respectively. The chelates were unambiguously identified by chromatographic comparison with spectroscopically characterised samples or known 99mTc-kit reconstitutions. The reaction succeeds under mild conditions (room temperature, short time, neutral or weak basic solutions) with high yields and has potential for labelling of sensitive biomolecules with 188Re.Applied Radiation and Isotopes 03/2006; 64(2):223-7. DOI:10.1016/j.apradiso.2005.08.001 · 1.23 Impact Factor
Article: Novel and Efficient Preparation of Precursor [ 188 Re(OH 2 ) 3 (CO) 3 ] + for the Labeling of Biomolecules[Show abstract] [Hide abstract]
ABSTRACT: A novel and efficient method for preparing 188Re(I) tricarbonyl precursor [188Re(OH2)3(CO)3]+ has been developed by reacting [188Re]perrhenate with Schibli's kit in the presence of borohydride exchange resin (BER) as a reducing agent and an anion scavenger. The precursor was produced in more than 97% yield by reacting a solution of tetrahydroborate exchange resin (BER, 3 mg), borane-ammonia (BH3.NH3, 3 mg), and potassium boranocarbonate (K2[H3BCO2], 3 mg) in 0.9% saline with a solution of sodium perrhenate (Na188ReO4) with up to 50 MBq and concentrated phosphoric acid (85%, 7 microL) at 60 degrees C for 15 min. HPLC and TLC revealed 0% unreacted [188Re]perrhenate ion and <3% of colloidal 188ReO2. Since the precursor is produced with high radiochemical purity and labeling efficiency under the milder conditions than those required for the conventional reducing agents, the latter can be replaced.Bioconjugate Chemistry 01/2006; 17(1):223-5. DOI:10.1021/bc050192t · 4.51 Impact Factor
Article: Mixed-Ligand Rhenium-188 Complexes with Tetradentate/Monodentate NS 3 /P ('4 + 1') Coordination: Relation of Structure with Antioxidation Stability[Show abstract] [Hide abstract]
ABSTRACT: Development of new radiopharmaceuticals based on rhenium-188 depends on finding appropriate ligands able to give complexes with high in vivo stability. Rhenium(III) mixed-ligand complexes with tetradentate/monodentate ('4 + 1') coordination of the general formula [Re(NS(3))(PRR'R' ')] (NS(3) = tris(2-mercaptoethyl)amine and derivatives thereof, PRR'R' ' = phosphorus(III) ligands) appear to be among the promising tools to achieve this goal. According to this approach, we synthesized and characterized a series of rhenium model complexes. In vitro stabilities of the corresponding rhenium-188 complexes were determined by incubating 2-3 MBq or alternatively 37 MBq of the complexes in phosphate buffer, human plasma, and rat plasma, respectively, at 22 degrees C or 37 degrees C, followed by checking the amount of (188)ReO(4)(-) formed after 1 h, 24, and 48 h by thin-layer chromatography. The rate of perrhenate formation varied over a wide range, depending primarily on the nature of the phosphorus(III) ligand. Physicochemical parameters of the corresponding nonradioactive rhenium complexes were analyzed in detail to find out the factors influencing their different stability and furthermore to design new substitution-inert '4 + 1' complexes. Tolman's cone angle of phosphorus(III) ligands and the lipophilic character of the inner coordination sphere were found to be crucial factors to build up stable rhenium '4 + 1' complexes. Additional information useful to describe electronic and steric properties of these compounds were selected from electronic spectra (wavelength of the Re-->S charge-transfer band), cyclovoltammetric measurements (E degrees of the Re(III)/Re(IV) couple), and NMR investigations ((31)P chemical shift of coordinated P(III) ligands).Bioconjugate Chemistry 05/2005; 16(3):634-43. DOI:10.1021/bc049745a · 4.51 Impact Factor
Article: Dramatic Effect of the Tridentate Ligand on the Stability of 99m Tc "3 + 1" Oxo Complexes Bearing Arylpiperazine Derivatives[Show abstract] [Hide abstract]
ABSTRACT: Mixed-ligand model complexes of general formula [(99m)Tc(O)(kappa(3)-PNX)(kappa(1)-SPh))] [X = O (1a), S (2a)] were prepared in a one-step procedure from [(99m)TcO(4)(-)] using stannous chloride as reducing agent. Stability studies and challenge experiments with glutathione showed that complex 2a presented promising features for pursuing animal studies. The activity in the brain (% dose injected/organ) at 5 min (0.14% +/- 0.03) and 120 min (0.11% +/- 0.02) pi encouraged the synthesis of several mixed-ligand "3 + 1" oxo complexes of general formula [M(O)(kappa(3)-PNS)(kappa(1)-SL))] (M = (99m)Tc, 3a-6a, Re, 3-6), in which the tridentate ligand is the heterofunctionalized phosphine 2-(diphenylphosphanyl)-N-(2-thioethyl)benzamide (PNS) and the co-ligands are different arylpiperazine derivatives (HSL1-HSL4). The (99m)Tc complexes have been characterized by comparison of their retention times in the HPLC chromatogram (gamma-detection) with the retention times of the analogous Re complexes (UV detection at 254 nm). The (99m)Tc complexes, obtained with radiochemical purity higher than 95%, after HPLC purification, are stable in saline, 0.01 M PBS (pH 7.4), rat plasma (4 h, 37 degrees C), and glutathione (10 mM solutions, 2h, 37 degrees C). Binding affinity and selectivity for 5-HT(1A) receptors (relative to the 5-HT(2A) receptor) were determined, complex 5 demonstrating the best values (IC(50) for the 5-HT(1A) 2.35 +/- 0.02 nM; competitor 5-HT(2A) 372 +/- 11 nM). Biodistribution and stability studies in mice indicated a preferred hepatobiliary excretion, a high in vivo stability, but a poor brain uptake.Bioconjugate Chemistry 05/2005; 16(3):660-8. DOI:10.1021/bc049718k · 4.51 Impact Factor
Article: Cyclopentadienyl tricarbonyl complexes of 99mTc for the in vivo imaging of the serotonin 5-HT1A receptor in the brain[Show abstract] [Hide abstract]
ABSTRACT: Technetium and rhenium tricarbonyl complexes with derivatized cyclopentadienyl ligands were prepared starting from pertechnetate and an appropriate ferrocene ligand. Furthermore, the complexes (M(CO)3cp-COOC5H9N-R, M=Tc, Re; R=Me, isopropyl) could be obtained starting from the precursor complexes [99mTc(CO)3(H2O)3]+ and [Re(CO)3Br3]2−. Their chemical identity was confirmed by chromatographic methods and electron spray mass spectrometry. The biodistribution of the 99mTc complexes (cytectrene I and cytectrene II) in Wistar rats was studied. Both compounds show high uptake in the brain and fast blood clearance. The pattern of regional distribution in the brain demonstrated in autoradiographic studies indicates binding to the 5-HT1A and α1 adrenergic receptors.Journal of Organometallic Chemistry 12/2004; 689(25):4739-4744. DOI:10.1016/j.jorganchem.2004.09.004 · 2.17 Impact Factor
Article: Synthesis and biological evaluation of silylated mixed-ligand Tc-99m complexes with the [PNS/S] donor atom set[Show abstract] [Hide abstract]
ABSTRACT: New oxotechnetium complexes of general formula [99mTc(O)(PNS)(S(CH2)nOSiR3)] (4-6) were synthesized by direct reduction of [99mTcO4]- with stannous chloride, in the presence of the tridentate heterofunctionalized phosphine H2PNS and of the monodentate silylated thiols [HS(CH2)nOSiR3] (n = 2, R = Ph (1); n = 3, R = Ph (2); n = 3, R = Et (3)). The mixed-ligand rhenium and technetium complexes of general formula [M(O)(PNS)(S(CH2)nOH)] (n = 2: M = 99mTc, (7), M = Re, (7a); n = 3: M = 99mTc, (8), M = Re, (8a)) were also prepared. All the 99mTc complexes were obtained with high radiochemical purity (> 95%), after purification by HPLC, and were characterized by comparison of their HPLC profiles with the ones obtained for the corresponding Re compounds. The silylated compounds 4-6 are stable in phosphate saline buffer (PBS) pH 7.4, rat plasma, human serum and whole blood, and do not bind to plasmatic proteins, and also do not challenge with glutathione. The biological behavior of [99mTc(O)(PNS)(S(CH2)nOH)] (7, 8) and [99mTc(O)(PNS)(S(CH2)nOSiR3)] (4-6) was studied. The effect of the pH on the cleavage of the O-Si bond in complexes 4-6 was also evaluated.Nuclear Medicine and Biology 09/2004; 31(6):785-93. DOI:10.1016/j.nucmedbio.2004.03.011 · 2.41 Impact Factor
Article: Novel Procedures for Preparing 99m Tc(III) Complexes with Tetradentate/Monodentate Coordination of Varying Lipophilicity and Adaptation to 188 Re Analogues[Show abstract] [Hide abstract]
ABSTRACT: Improved methods are presented for the preparation of 99mTc and 188Re mixed-ligand complexes with tetradentate and monodentate ligands of the general formula [MIII(Lm)(Ln)] (M = Tc, Re; Lm = NS3 or NS3COOH; Ln = isocyanide or phosphine). To avoid the undesired formation of reduced-hydrolyzed species of both metals, the preparation of complexes is performed in a two-step procedure. At first the Tc(III)- or Re(III)-EDTA complex is formed which reacts in a second step with the tripodal ligand 2,2',2' '-nitrilotris(ethanethiol) (NS3) or its carboxyl derivative NS3COOH (a) and the monodentate phosphine ligands (triphenylphosphine L1, dimethylphenylphosphine L2) or isocyanides (tert-butyl isonitrile L3, methoxyisobutyl isonitrile L4, 4-isocyanomethylbenzoic acid-L-arginine L5, 4-isocyanomethylbenzoic acid-L-arginyl-L-arginine L6, 4-isocyanomethylbenzoic acid-neurotensin(8-13) L7) to the so-called '4+1' complex. Copper(I) isocyanide complexes are used for preparing the '4+1' complexes. That facilitates storage stability and allows kit formulations, and, moreover, enables the formation of 188Re complexes in acidic solution. Only micromolar amounts of the monodentate ligand are needed, and that results in high specific activity labeling of interesting molecules. The lipophilicity of complexes can be controlled by introducing a carboxyl group into the tetradentate ligand and/or derivatization of the monodentate ligands. Furthermore, the carboxyl group enables the conjugation of biomolecules. As an example, the neurotensin derivative CN-NT(8-13) was prepared and labeled with 99mTc according to the '4+1' approach, and its behavior in vivo was studied.Bioconjugate Chemistry 07/2004; 15(4):856-63. DOI:10.1021/bc0300798 · 4.51 Impact Factor
Article: Novel tumortropic ester derivatives of 99mTc(V) mesodimercapto succinic acid with low affinity for bone tissue[Show abstract] [Hide abstract]
ABSTRACT: Starting from our previous finding that 99mTc(V) dimercaptosuccinic acid (99mTc(V)-DMSA), a useful agent for the localization of osteosarcoma and bone metastases, loses its bone affinity when one ester group is introduced into the complex we studied the impact of esterification in more detail. This paper reports on the evaluation of various ester complexes of 99mTc(V)-DMSA in rats and tumour-bearing nude mice with regard to their tumour retention and improvement of the tumour to tissue ratios. The distribution patterns of the complexes [99mTcO(DMSA)2]- (A), [99mTcO(DMSA/DMSEt)]- (B) and [99mTcO(DMSEt)2]- (C) are gradually changed with the number of ester groups in the anionic complex. However, the asymmetric diester complex [99mTcO(DMSA/DMSEt2)]- (D) is very slowly cleared, especially from the blood of nude mice. Moreover, this complex differs significantly from the symmetrical complex C in its elimination behaviour from the liver and kidneys. The tumour uptake is maintained with complexes that contain one or two non-hydrolysable ester functions. Preliminary biodistribution studies of the monoethyl and diethyl ester complexes B, C and D in comparison with A in tumour-bearing nude mice showed similar uptake into the human squamous cell carcinoma (FaDu) as well as into the human colonic cell carcinoma (HT29) of nude mice. The low bone accumulation of B, C and D results in excellent tumour-to-bone ratios, e.g., approx. 3:1 for the ester complex B compared to approx. 1:2 for complex A. Differences were observed in the accumulation and elimination behaviour of the complexes A and B in various bone structures of rats. The age-dependent uptake of A and B was compared in long bone (femur) and in cranial bone of rats. The results suggest that 99mTc(V)-DMSA complexes that contain a functional ester, and their 188Re analogues, may be superior to 99mTc(V)/188Re(V)-DMSA in diagnostic and therapeutic nuclear medicine.Nuclear Medicine Communications 11/2003; 24(11):1175-83. DOI:10.1097/01.mnm.0000101611.64255.78 · 1.67 Impact Factor
Article: Synthesis, Characterization, and Biological Evaluation of Technetium(III) Complexes with Tridentate/Bidentate S,E,S/P,S Coordination (E = O, N(CH 3 ), S): A Novel Approach to Robust Technetium Chelates Suitable for Linking the Metal to Biomolecules[Show abstract] [Hide abstract]
ABSTRACT: A novel type of mixed-ligand Tc(III) complexes, [Tc(SCH(2)CH(2)-E-CH(2)CH(2)S)(PR(2)S)] (E = S, N(CH(3)); PR(2)S = phosphinothiolate with R = aryl, alkyl) is described. These "3+2"-coordinated complexes can be prepared in a two-step reduction/substitution procedure via the appropriate chloro-containing oxotechnetium(V) complex [TcO(SES)Cl] [E=S, N(CH(3)]. Tc(III) compounds have been fully characterized both in solid and solution states and found to adopt the trigonal-bipyramidal coordination geometry. The equatorial trigonal plane is formed by three thiolate sulfur atoms, whereas the phosphorus of the bidentate P,S ligand and the neutral donor of the tridentate chelator occupy the apical positions. The (99)Tc(III) complexes have been proven to be identical with the (99m)Tc agents prepared at the no-carrier-added level by comparison of the corresponding UV/vis and radiometric HPLC profiles. Challenge experiments with glutathione clearly indicate that this tripeptide has no effect on the stability of the (99m)Tc complexes in solutions. Biodistribution studies have been carried out in rats at 5 and 120 min postinjection. The substituents at the bidentate P,S ligand significantly influence the biodistribution pattern. Remarkable differences are observed especially in brain, blood, lungs, and liver. All the complexes are able to penetrate the blood-brain barrier of rats and showed a relatively fast washout from the brain.Bioconjugate Chemistry 01/2003; 14(1):136-43. DOI:10.1021/bc025575v · 4.51 Impact Factor
Article: Synthesis, biological and autoradiographic evaluation of a novel Tc-99m radioligand derived from WAY 100635 with high affinity for the 5-HT1A receptor and the alpha1-adrenergic receptor[Show abstract] [Hide abstract]
ABSTRACT: This paper reports the synthesis, biological evaluation, in vitro and ex vivo autoradiography of the first Tc-99m ligand with subnanomolar affinity for the 5-HT(1A) receptor and a remarkably high affinity for the alpha1-adrenergic receptor. The neutral "3+1" mixed-ligand complex combines 4-(6-mercaptohexyl)-1-(2-methoxyphenyl)piperazine as monodentate and 3-(N-methyl)azapentane-1,5-dithiol as tridentate unit with oxotechnetium(V). The analogous rhenium complex was synthesized for complete structural characterization and used in receptor binding assays. In competition experiments both complexes display subnanomolar affinity for the 5-HT(1A) receptor (IC(50)0.24 nM for Re, 0.13 nM for Tc) but also very high affinities for the alpha1-adrenergic receptor (IC(50) 0.05 nM for Re, 0.03 nM for Tc). Biodistribution studies show a brain uptake in rat of 0.22% ID five minutes post injection. In vitro autoradiographic studies in rat brain and postmortem human brain indicate accumulation of the Tc-99m complex in brain areas which are rich in 5-HT(1A) receptors or in alpha1-adrenergic receptors. This in vitro enrichment can be blocked respectively by the 5-HT(1A) receptor agonist 8-OH-DPAT or by prazosin hydrochloride, an alpha1-adrenergic receptor antagonist. Ex vivo autoradiographic studies in rats show a slight accumulation of the Tc-99m complex in 5-HT(1A) receptor-rich areas of the brain, which could not be blocked, as well as in regions rich in alpha1-adrenergic receptors, which could be blocked by prazosin hydrochloride.Nuclear Medicine and Biology 06/2002; 29(4):375-87. DOI:10.1016/S0969-8051(01)00313-4 · 2.41 Impact Factor
Article: Synthesis and biological evaluation of technetium(III) mixed-ligand complexes with high affinity for the cerebral 5-HT1A receptor and the alpha1-adrenergic receptor[Show abstract] [Hide abstract]
ABSTRACT: Tc(III) and Re(III) complexes [M(NS(3))(CNR)] (M = Re, 99mTc, NS(3) = 2,2',2"-nitrilotris(ethanethiol), CNR = functionalized isocyanide bearing a derivative of WAY 100635) have been synthesized and characterized. Re was used as Tc surrogate for chemical characterization and in vitro receptor-binding studies. For two representatives subnanomolar affinities for the 5-HT(1A) as well as for the alpha1-adrenergic receptor were reached. Biodistribution studies in rats of the 99mTc complexes showed brain uptakes between 0.3 and 0.5% ID/organ (5 min p.i.). In vitro autoradiography of one 99mTc representative in sections of post mortem human brain indicate its accumulation in 5-HT(1A) receptor-rich brain regions. However, addition of the specific 5-HT(1A) receptor agonist 8-OH-DPAT as well as the alpha1-adrenoceptor antagonist prazosin could not substantially block this tracer accumulation. A preliminary SPET study in a monkey showed negligible brain uptake.Nuclear Medicine and Biology 06/2002; 29(4):389-98. DOI:10.1016/S0969-8051(02)00296-2 · 2.41 Impact Factor
Article: Reactivity of technetium(I) thioether carbonyl complexes towards histidine - An EXAFS study in solution[Show abstract] [Hide abstract]
ABSTRACT: Technetium(I) thioether carbonyl complexes and their reaction products with histidine were prepared and characterised by Extended X-ray Absorption Fine Structure (EXAFS) spectroscopy, various chromatographic and electrophoretic methods and electrospray mass spectrometry. Their behaviour in aqueous solutions was studied on the carrier-added (99Tc) and the no-carrier-added (99mTc) levels. HPLC and electrophoretic studies show the identity of reaction products at both concentration levels. Technetium(I) carbonyl complexes containing a bidentate dithioether ligand [Tc(CO)3Cl(SS)], as well as a tridentate carboxylato thioether ligand [Tc(CO)3(SSO)], undergo a ligand exchange reaction with histidine and form the complex [Tc(CO)3His]. EXAFS measurements were performed to estimate the structural parameters of the dissolved technetium(I) carbonyl complexes and their reaction products after the challenge experiments. The calculated bond lengths and coordination numbers are in agreement with the expected values and confirm the ligand exchange reactions.Inorganica Chimica Acta 10/2001; 322(s 1–2):79–86. DOI:10.1016/S0020-1693(01)00544-8 · 2.05 Impact Factor
Article: Novel technetium(III) mixed-ligand chelates for the design of lipophilic complexes stable in vivoJournal of Labelled Compounds 05/2001; 44(S1). DOI:10.1002/jlcr.2580440114 · 1.27 Impact Factor
Article: Tc Oxocomplexes with the PNO/S and PNS/S donor atom sets: Labelling of a 5HT1A receptor - binding ligand[Show abstract] [Hide abstract]
ABSTRACT: Mixed — ligand model complexes, [99mTc(O)(PNX)(SPh)] (XO (1a), S (2a)), were synthesized from [99mTcO4]−. These compounds were characterized by comparing their radioactive HPLC profiles with the UV profiles of the analytically pure Re compounds 1 and 2. Based on stability studies, undertaken in aqueous solutions and in glutathione challenge experiments, 2a was chosen for biodistribution studies in rats. Using this approach, the labelling of a 5‐HT1A receptor ligand (derivatized aryl‐piperazine) with 99mTc was also performed using the PNS chelate.Journal of Labelled Compounds and Radiopharmaceuticals 05/2001; 44(S1). DOI:10.1002/jlcr.25804401184 · 1.27 Impact Factor
Article: Ligand-exchange reaction of labile "3+1"99mTc(V) complexes with SH group-containing proteins[Show abstract] [Hide abstract]
ABSTRACT: The reactivity of labile 3 + 1 mixed-ligand 99mTc complexes of the type [99mTcO(SES)(RS)] with SES being a tridentate dithiol ligand and glutathione or dimethylcysteamine as monodentate ligands RSH towards proteins was investigated in vitro and in vivo. It was found that the complexes undergo reversible transchelation reactions with SH group-containing components of blood such as albumin or haemoglobin. High labelling yields were obtained when 3 + 1 complexes with the tridentate SSS ligand were used. The biodistribution of blood proteins labelled by ligand-exchange reaction with the [99TcO(SSS)] or [99mTcO(SNMeS)] core was studied and compared with the in vivo distribution of the labile 3 + 1 complexes containing glutathione as monodentate ligand.Applied Radiation and Isotopes 05/2001; 54(4):637-44. DOI:10.1016/S0969-8043(00)00309-2 · 1.23 Impact Factor
Article: Autoradiographical evaluation of novel high-affinity Tc-99m ligands for the serotonin 5-HT1A receptorJournal of Labelled Compounds 05/2001; 44(S1). DOI:10.1002/jlcr.25804401193 · 1.27 Impact Factor
Top Journals
Helmholtz-Zentrum Dresden-Rossendorf
Dresden, Saxony, Germany
- Institute of Radiopharmacy
Technische Universität DresdenDresden, Saxony, Germany
Bundesanstalt für Materialforschung und -prüfungBerlín, Berlin, Germany
Paul Scherrer InstitutAargau, Switzerland


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Villa Ekim
from £72 /night help Price for guests, Nights
1 review
from £72 /night help Price for guests, Nights
Estimated nightly price based on a weekly stay. Excludes fees (if applicable). Enter your dates to see the total cost.
Villa / 4 bedrooms / sleeps 8 Home 1375694
Availability Your dates are available
Villa / 4 bedrooms / sleeps 8
|Key Info
Villa Ekim is a 4 bedroom, 3 bathroom property located in Ovacik in South West Turkey. The villa is a 5 minute walk to the lively resort of Hisaronu and a 10 min bus ride (dolmus) to the beautiful Olu Deniz beach. Fethyie is also only 15 minutes away by bus.
This is a private villa, with its own gated entrance. Steps lead down into the front garden area, with access to the private pool. Upon entering the property, you come into a spacious reception area with access to the fully equipped kitchen with all mod cons including dishwasher, oven and electric hob ( the washing machine is located on the lower ground floor ) . The open plan lounge is also situated on the ground floor with fire and a 32 inch flat screen TV, complete with DVD player. The patio doors in the living room and kitchen lead onto a spacious private wrap around terrace, which also allows access to the private pool, pool area and gardens. The gardens are well appointed, and we welcome you to make use of the brick built barbeque and dine al-fresco. There is also a pay as you go WIFI available in the Villa.
Marble stairs take you to the first floor where you find the master bedroom complete with a private balcony and en-suite bathroom. The upper floor also has a twin bedroom, again complete with a private balcony, and a family bathroom. There are a further 2 bedrooms on the lower ground floor a twin room and a double room, there is a family bathroom on the lower ground floor. We also have a chill out room with 2 double sofa beds for those hot days, there is also a small utility area in this room where you will find the washing machine and iron/ironing board.
The villa is air conditioned.
Transfers are £80 return up to 4 people an additional passengers charged at £20 return per person. Transfers payable in resort.
Please do not leave children unsupervised in and around the pool area
Please ensure that you have adequate Travel insurance
As we do not request a breakages deposit we reserve the right to request payment for any damages during your stay at the villa once it has been inspected on your departure. On your return home, any such damages will be billed for by us to your home address for the exact cost of recovery.
THE AREA - Ovacik /Hisaronu
The villa is situated in a quieter area, being only 5 minutes away from all the action of the resort you can spend your time here as relaxed or active as you choose with something for everyone.
Hisaronu is a resort perched 1500ft above sea level packed with shops, ATM's, Restaurants for all tastes. Hisaronu is a 5 minute walk away or you can catch the dolmus at the top of the road for a 2 min bus ride.
The resort area has a welcoming breeze on returning from the hot beach area during the day.
THE BEACH – Olu Deniz
Just 10mins drive from the villa down the winding mountain road is a stunning bay with a laid back atmosphere and one of the most beautiful beaches in Turkey.
You can walk along the promenade and stop for lunch and drinks in one of the many beach bars or watch the paragliders landing on the beach. It is regarded as one of the best places in the world to paraglide due to its unique panoramic views, and the Babadag mountain's exceptional height.
Visit the lagoon area which is a national nature reserve and well worth the small entrance fee, it has sunbeds & parasols, showers/toilets and a refreshments area. On one side lie the calm waters of the lagoon, which is peaceful for picnics and relaxing.- on the other side is the warm clear waters of the mediterranean.
Boat trips depart from here.
The temperatures can be extremely hot during July and August.
THE TOWN – Fethiye
10 mins drive in the other direction takes you to the wonderful market town of Fethiye. With its Pastpatur area (harbour bazaar) catering for tourists it has plenty of shops/bars and international restaurants that are well worth a visit. Right in the centre of town is the fish/veg market which has incredible bargains for that special barbeque. Alternatively buy your fish and one of the restaurants surrounding the market will create a delicious meal for you for around £2. The market is on every Tuesday in Fethiye.
You can take the 12 islands boat trip from the harbour area or a water taxi across to Calis Beach for a change of scenery
HISTORY – Kaya Koy Ghost village
10 mins drive through the village of Hisaronu is the aptly named ghost village. The houses here were once occupied by the greeks until the 1920's when they were repatriated back to Greece. The Turkish people refused to live in the properties for the worry of them being cursed and so they have remained empty ever since. Most of the buildings are still standing but in a state of dilapidation. You can walk through the houses in the village up the hill to the church at the top giving you a sense of the scale of the village and what life was like and has splendid views of the landscape or over the back of the lagoon follow the waymarked signs to Oludeniz.
Walking/Cycling/Horse Riding
Pedaloes/Water Skiing/Jetskiing
Kayaking/Snorkelling/Scuba diving
White water Rafting
Saklikent Gorge
Mudbaths and rock tombs in Dalyan
|Sleeps up to 8, 4 bedrooms
|4 bedrooms, 3 bathrooms of which 2 Family bathrooms and 1 En suites
|Family friendly
|Great for children of all ages
|No pets allowed, No smoking at this property
Features and Facilities
|Log fire, DVD player
|Private outdoor pool (unheated)
|Air conditioning, TV, CD player, Safe, Satellite TV
|Kettle, Toaster, Iron, Hair dryer
|Clothes dryer, Dishwasher, Cooker, Microwave, Fridge, Freezer, Washing machine
|4 Sofa beds, Double beds (2), Single beds (4), Cots (1), Dining seats for 10, Lounge seats for 6
|Linen provided, Towels provided
|Private outdoor pool (unheated), Balcony or terrace, Private garden, BBQ
|Parking, Not suitable for wheelchair users
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Calendar last updated:05 Oct 2015
Based in United Kingdom
- English


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Jeff Tedford was flagged for unsportsmanlike conduct for excessive arguing after Keenan Allen's helmet was ripped off by Oregon State's Uani Unga on a kick return and there was no flag thrown.
7 Comments
Amazing how easy it is for officials to take the bears out of the game.
I think the bears are saving their energy for the second half because you know, according to Tedford, you may lose the whole game but as long as you win the (first or) second half, you are basically tied, and that's OK.
True but this is the worst officiated game I have ever seen. Totally unacceptable.
This disaster is not about the referees. JT can blame anyone he wants, and surely he will, but he needs to look in the mirror.
We weren't going to beat these guys anyway, but the refs made sure of that. My blood is boiling right now because we never had a shot. These refs are comical.
JT never blames anyone but himself. I challenge you to find a single comment he has made over the last decade that implies he wasn't accepting full responsibility for a loss.
Good for Jeff! The refs did call some shady penalties.


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Markets rallied for the third week in a row, sending stocks to new all-time highs on the back of a strong May jobs report. For the week, the S&P 500 rose 1.34%, the Dow gained 1.24%, and the Nasdaq grew 1.86%.[1]
Markets shot up on Friday after a better-than-expected jobs report showed slow and steady improvement in the labor market. Here are some high level takeaways: The economy gained 217,000 new jobs in May, many in business services and healthcare, indicating that the quality of available jobs may also be improving. Though headline unemployment is unchanged at 6.3%, digging deeper, we can see that the number of people who can't find full-time jobs has fallen, as has the number who are forced to work part-time for lack of better options.[2] This is great news for the labor market.
We also want to point out an important milestone reached last month: The economy has regained all of the jobs lost in the recession. The chart below shows that total nonfarm employment in the U.S. reached 138.5 million in May, up 8.8 million since the bottom of the recession in 2010.[3]
While this is a noteworthy event, when we consider population growth and labor force growth, employment is still below healthy levels and the labor market still has a ways to go.
Wednesday: EIA Petroleum Status Report, Treasury Budget
Thursday: Jobless Claims, Retail Sales, Import and Export Prices, Business Inventories
Friday: PPI-FD, Consumer Sentiment
Notes: All index returns exclude reinvested dividends, and the 5-year and 10-year returns are annualized. Sources: Yahoo! Finance and Treasury.gov. International performance is represented by the MSCI EAFE Index. Corporate bond performance is represented by the DJCBP. Past performance is no guarantee of future results. Indices are unmanaged and cannot be invested into directly.
Student loan debt behind housing stall? A former Federal Housing Administration head blames crushing student debt loads for delayed household formation and lackluster home sales. Higher housing prices in desirable urban areas may also make it challenging for first-time homebuyers to purchases homes.[5]
Motor vehicle sales rise. Auto sales surged last month, rising 11%, confirming that cold winter weather was the main factor in weak demand early this year. Despite issues with recalls on some brands, several automakers logged double-digit monthly sales growth.[8]


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Art and Design/* BEGIN: Block 2 of 2 Greg Add 2013 (Jan 29) */ ?> /* END: Block 2 of 2 Greg Add 2013 (Jan 29) */ ?>
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Want This New Invention? 3D Printed Crab Shellsby Laurie Kay Olson
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Toyota Aygo: With This City Car's Fourth Generation, X Marks The Spotby Motors.new
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Snow Globe Rings Let You Give Winter The Fingerby Steve Levenstein
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Peter--sorry I didn't respond right away. I've been too busy to organize anything lately, but if someone else wants to organize something, I'll try to make it if I can.
Thanks, Art. I was shooting the Linhof Tech V 4x5" on Halloween.
Dave, I also get to Vegas periodically. My parents live there, and I usually have a meeting in the region once a year for something else, and my sister is in LA.


text:
Like us on Facebook for inter-esting movie poster-related stuff:
The Shop Around the Corner posterCopyright by respective production studio and/or distributor. Intended for editorial use only.
Directed by: Ernst Lubitsch
Cast: James Stewart, Felix Bressart, Inez Courtney, Sara Haden, Charles Halton, Edwin Maxwell, Frank Morgan, Joseph Schildkraut, Charles Smith, William Tracy, Margaret Sullavan


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The writers of every age, if they pay any attention to the past, are given to choosing from earlier authors those whose views are sympathetic with their own. So we see the Philosophes ranging over the past, and praising writers who in some degree had ideas similar to their own, and borrowing freely from these authors.
Most of the thinkers of the Eighteenth Century were early trained in the Greek and Latin classics which were still the basis of education, and the classics, either in the original languages or in translation, with their generally worldly attitudes were used as examples of more reasonable ways of thinking than those set up by Christianity. The common attitude of Eighteenth Century intellectuals toward antiquity was one of admiration, but they usually opposed a mere antiquarianism, and held that modern man should imitate only what was worth imitating.
An important background for the Philosophes, as for Karl Marx later, was furnished by the ethics and some of the general attitudes of Christianity. One could never imagine the En


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New Te Reo Maori app targets total beginnersFeb 16
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Victoria University of Wellington's Faculty of Education has released its second Te Reo Maori learning app, Puna. Read More →
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The Educa app that enables communication of learning stories and updates between education centres and parents is now available in Te Reo Māori. Read More →
A new bilingual app 'Māui and His First Journey' has just been launched that reinforces positive parenting, child development and brain development through interactive story telling. Read More →
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Physical Description
Type Information
Catalog Number: US 2442699
Collection: Smithsonian Institution, National Museum of Natural History, Department of Botany
Verification Degree: Original publication and alleged type specimen examined
Preparation: Pressed specimen
Collector(s): W. A. Kellerman
Year Collected: 1907
Locality: El Rancho, Jalapa, Guatemala, Central America
Elevation (m): 1000 to 1000
- Isotype: Britton, N. L. & Rose, J. N. 1928. N. Amer. Fl. 23: 81.
Catalog Number: US 1151978
Collection: Smithsonian Institution, National Museum of Natural History, Department of Botany
Verification Degree: Card file verified by examination of alleged type specimen
Preparation: Pressed specimen
Collector(s): S. Calderón
Year Collected: 1922
Locality: Cerro de La Olla, near Chalchuapa., Santa Ana, El Salvador, Central America
- Type collection: Britton, N. L. & Rose, J. N. 1925. N. Amer. Fl. 28: 82.
Catalog Number: US 1080750
Collection: Smithsonian Institution, National Museum of Natural History, Department of Botany
Verification Degree: Original publication and alleged type specimen examined
Preparation: Pressed specimen
Collector(s): C. Conzatti
Year Collected: 1907
Locality: El Parian., Nochixtlan, Oaxaca, Mexico, North America
Elevation (m): 1000 to 1000
- Type collection: Britton, N. L. & Rose, J. N. 1928. N. Amer. Fl. 23: 83.
Catalog Number: US 1209403
Collection: Smithsonian Institution, National Museum of Natural History, Department of Botany
Verification Degree: Original publication and alleged type specimen examined
Preparation: Pressed specimen
Collector(s): C. A. Purpus
Year Collected: 1925
Locality: Banks of creek W of Monserrate., Chiapas, Mexico, North America
- Type collection: Britton, N. L. & Rose, J. N. 1928. N. Amer. Fl. 23: 83.
Catalog Number: US 1137014
Collection: Smithsonian Institution, National Museum of Natural History, Department of Botany
Verification Degree: Original publication and alleged type specimen examined
Preparation: Pressed specimen
Collector(s): P. C. Standley
Year Collected: 1922
Locality: Vicinity of San Vicente., San Vicente, El Salvador, Central America
Elevation (m): 350 to 500
- Type collection: Britton, N. L. & Rose, J. N. 1928. N. Amer. Fl. 23: 83.
Sierra de la Laguna Dry Forests Habitat
This taxon is found in the Sierra de la Laguna dry forests ecoregion, which was once an isolated island, containing a large number of endemic species. After sufficient mountain uplift and the joining the Baja Peninsula mainland, this ecoregion underwent significant speciation, and is thus today high in species diversity; this portion of the peninsula contains the majority of the species found in the southern part of the Baja Peninsula. The region is shaped by a vast complex of granitic mountains, running southward from the Gulf of California to the Pacific. These mountains are dissected by valleys and canyons, and surrounded by vast plateaus.
The forest is transitional both with the pine oak forests at higher elevations, and with the xeric scrub at lower portions. The dry forest of Sierra de la Laguna is characterized by abundance of low trees and scrubs, and poor vertical stratification. The dominant tree species in the subtropical forest are Mauto (Lysiloma divaricatum), Palo Blanco (L. candida), Elephant Tree (Bursera microphylla) and Palo Zorrillo (Hesperalbizia occidentalis). Herbaceous elements are poorly developed, but their representatives are Caribe (Cnidoscolus angustidens), Spiny Aster (Chloracantha spinosa var. strictospinosa), Solanum spp., and cacti such as Biznaga (Ferocactus spp).
A number of reptilian taxa are found in the ecoregion, including: the endemic Baja California Rat Snake (Bogertophis rosaliae); Hunsaker's Spiny Lizard (Sceloporus hunsakeri); Belding's Orange-throated Whiptail (Cnemidophorus hyperythrus); Spiny Chuckwalla (Sauromalus hispidus NT); San Lucan Leaf-tailed Gecko (Phyllodactylus unctus NT); Baja California Night Snake (Hypsiglena slevini), a Mexican endemic rangeing from Bahía San Juanico, in the east-central Baja California Peninsula, southward continuously Cabo San Lucas (as well as on the island of Santa Margarita and on Cerralvo and Danzante islands in the Gulf of California; and Hunsaker's Spiny Lizard (Sceloporus hunsakeri), endemic to the Cape Region of Baja California Sur and the Gulf of California islands of Espiritu Santo, Gallo, Ballena and Partida Sur.
There are a number of mammalian species occurring in the Sierra de la Laguna dry forests. Among the mammals found here are: Eva's Desert Mouse (Peromyscus eva), endemic to Baja California Sur; Mexican Funnel-eared Bat (Natalus stramineus); the near-endemic Peninsular Bat (Myotis peninsularis EN), chiefly found in Baja California Sur; Dalquest's Pocket Mouse (Chaetodipus dalquesti VU), known only from the Cape Region of Baja California Sur.
San Lucan Xeric Scrub Habitat
This taxon is found in the San Lucan xeric scrub, an ecoregion situated at the southern-most part of the Baja Peninsula of Mexico; this diverse landscape of mountains, valleys, and plateaus is covered with a variety of species of xeric vegetation. This neotropical ecoregion is classifed within the Deserts and Xeric Scrublands biome. Plants and animals of this region evolved independently before the Baja Peninsula, a previous island during the Miocene, joined the mainland. An arid climate supports a number fauna and species, about ten percent which of which are endemic.
The ecoregion took shape in the Miocene as an isolated landform prior to joining the peninsula, and thus can be considered an biogeographical island of vegetation. This arid landscape is composed of a vast, rugged complex of granitic mountains, valleys, canyons, and plateaus. The ecoregion occupies the plateaus between the coast and the lower limits of the dry forests, which begin around 250 meters. Precipitation is about 400 millimetres annually.
Some elements of dry forest habitat are present in this ecoregion, but xeric elements are dominant and include Chain-link Cholla (Opuntia cholla); Elephant Tree (Bursera microphylla), at the southern limit of its range here and extending north to the Waterman Mountains in the USA; Mauto (Lysiloma divaricata); Organ Pipe Cactus (Stenocereus thuberi), Mala Mujer (Cnidoscolus angustidens), Yucca spp., and Barrel Cacti (Ferocactus spp). Herbaceous elements in the ecoregion include Plantago linearis, Bouteloua hirsuta, and Commelina coelestis.
The San Lucan xeric scrub harbours 31 of 48 of the reptile species for the Cape Region. Almost a third of the wider regional recorded species of collembola arthropods and spiders (30 of 138 species, respectively) occur in this ecoregion. In general, over ten percent of animal and plant species found here are endemic.
Within the San Lucan xeric scrub ecoregion, reptilian taxa include: the endemic Island Burrowing Sand Snake (Chilomeniscus punctatissimus); the endemic Isla Cerralvo Snake (Chilomeniscus savagei), restricted solely to Cerralvo Island; the Cape Arboreal Spiny Lizard (Sceloporus licki), a near-endemic restricted to the southern portion of the Baja Peninsula; the near-endemic Spiny Chuckwalla (Sauromalus hispidus NT), found only on Angel de la Guarda Island, Granito, Mejía, Pond, San Lorenzo Norte, San Lorenzo Sur, and other islands in Bahía de los Ángeles, including Cabeza de Caballo, La Ventana, Piojo, Flecha, Mitlàn, and Smith, Gulf of California; the near-endemic San Lucan Leaf-toed Gecko (Phyllodactylus unctus NT), found only on southern Baja Peninsula and some islands within the Gulf of California: Gallo, Partida Sur, Espiritu Santo, Ballena, Gallina and Cerralvo. There are only a small number of anuran species present in the ecoregion: Red-spotted Toad (Anaxyrus punctatus); and Pacific Chorus Frog (Pseudacris regilla).
The Espiritu Santo Island Antelope Squirrel (Ammospermophilus insularis) is endemic to the San Lucan xeric scrub ecoregion and is found only on the island of Espiritu Santo in the Gulf of California. Among threatened mammals occurring in the ecoregion are: the near-endemic Dalquest's Pocket Mouse (Chaetodipus dalquesti VU), known from the Cape Region of the Baja California Peninsula.
Threatened mammals in the ecoregion include: the near-endemic Peninsular Myotis (Peninsular Myotis EN), found only on southern Baja Peninsula; Fish-eating Bat (Myotis vivesi VU), a near-endemic occurring chiefly on the near-shore islands off of the southern Baja Peninsula and mainland Sonora; Mexican Long-tongued Bat (Choeronycteris mexicana NT); and the Lesser Long-nosed Bat (Leptonycteris yerbabuenae VU).
Southern Pacific Dry Forests Habitat
This taxon is found in the Southern Pacific dry forests ecoregion, which is situated along the southeastern versant of the Sierra Madre del Sur Mountains including the Pacific Ocean coastal plain. These forests are a key locus of endemism for butterflies, and has the greatest diversity of scorpions and spiders in the entirety of Mexico. This ecoregion is classified in the Tropical and Subtropical Dry Broadleaf Forests biome. The Southern Pacific dry forests exhibit a moderate to high faunal species richness; for example, there are a total of 744 vertebrate taxa recorded in the ecoregion, with a particularly large number of endemic reptiles.
The ecoregion elevation ranges from sea level to 1400 metres. The climate is tropical and dry, with precipitation levels of 800 millimetres (mm) per annum. There is an extended arid season, which factor drives the prevalence of deciduous vegetation. The forests grow chiefly on shallow, well-drained soils derived from limestone. Closer to the base of the Sierra Madre del Sur Mountains, the soils are more rocky, and are derived from igneous rocks.
The dominant plant species include Mauto (Lysiloma divaricatum), Bursera excelsa and Fragrant Bursera (B. fagaroides), which are typically found in association with Pochote (Ceiba aesculifolia), Comocladia engleriana, and Trichilia americana. In the Mexican state of Michoacán, the macro plant species more generally in evidence are Ficus insipida, F. pertusa, Breadnut (Brosimum alicastrum), Licania arborea, Sideroxylon capiri and Elephant Ear (Enterolobium cyclocarpum).
There are a number of anuran species present in the ecoregion, including: Blunt-toed Chirping Frog (Eleutherodactylus modestus VU); Cloud Forest Stream Frog (Ptychohyla euthysanota NT), found from southeast Oaxaca to Guatemala and eastern El Salvador; Matuda's Spikethumb Frog (Plectrohyla matudai VU). A special status caecilian found in the ecoregion is the Mexican Caecilian (Dermophis mexicanus VU), a fossorial species that can attain lengths up to sixty centimetres. A special status salamander found in the ecoregion is the Sierra Juarez Salamander (Pseudoeurycea juarezi CR), a near-endemic known only between Cerro Pelón and Vista Hermosa in the Sierra de Juarez, north-central Oaxaca. The White-lipped Peeping Frog (Eleutherodactylus albolabris CR), a near-endemic known chiefly from Agua del Obispo, central Guerrero.
The Southern Pacific dry forests contain numerous reptilian taxa, including the following endemics: Bocourt's Anole (Norops baccatus); Taylor's Anole (Norops taylori), known only to Puerto Marquez area, in northern Acapulco, Guerrero; Simmons' Anole (Anolis simmonsi), restricted to the vicinity of Pinotepa Nacional, Oaxaca; Stegneger's Blackcollar Spiny Lizard (Sceloporus stejnegeri), restricted to the Pacific versant in the state of Guerrero, Mexico; Red Earth Snake (Geophis russatus), found in a very narrow range outside of Putla, Oaxaca; Sierra Mije Earth Snake (Geophis anocularis), known only from around Totontepec on the Atlantic versant of the Sierra Mixe, Oaxaca; Ramirez`s Hooknose Snake (Ficimia ramirezi), restricted to the Pacific versant of the Isthmus of Tehuantepec, Niltepec, Oaxaca; Halberg's Cloud Forest Snake (Cryophis hallbergi), found only in northern Oaxaca, at Sierra de Juarez and Sierra Mazateca; Isthmian Earth Snake (Geophis isthmicus), known only from the vicinity of Tehuantepec, Mexico; the endemic Macdougall's Spiny Lizard (Sceloporus macdougalli).
Characteristic mammalian fauna include the endemic Oaxacan Pocket Gopher (Orthogeomys cuniculus), restricted to several sites on the Isthmus of Tehuantepec, Oaxaca. Other mammals seen in the ecoregion include the: Lesser Long-nosed Bat (Leptonycteris yerbabuenae VU), Tropical Hare (Lepus flavigularis EN), restricted to Salina Cruz, Oaxaca to the extreme west of Chiapas; Greater Bulldog Bat (Noctilio leporinus), Coati (Nasua narica), Buller's Pocket Gopher (Pappogeomys bulleri), Javelina (Tayassu tajacu), and Mexican Long-tongued Bat (Choeronycteris mexicana NT).
Molecular Biology and Genetics
Molecular Biology
Statistics of barcoding coverage: Lysiloma divaricatum
Public Records: 0
Specimens with Barcodes: 2
Species With Barcodes: 1
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Check out today's front page. Updated daily after the print edition goes to press.
FALL RIVER – It's the kind of dilemma only superb athletes deal with.
The 2014-15 Celtics averaged more than 100 points for the first time since the 2008-09 season, and they will rely on ball movement to produce even more in the season ahead.
Bruins captain Zdeno Chara, sidelined since Sept. 24 by an upper body injury, agreed to skip Thursday's 2015-16 opener against the Jets. The B's don't want Chara, who is practicing, to risk re-injury so early in the season.
The Herald News staff reporters take a crack at picking this weekend's local high school football games.
Introducing your new, hypothetical Fall River City Council: Richard Cabeceiras, Linda Pereira, Scott Donnelly, Shawn Cadime, Earle Gaudette, Jason Caminiti, Trottjoseph Lee, Jack Raposo and Cliff Ponte.
After two straight losses which stopped their record to 1-3, the Durfee Hilltoppers look to get back on track this evening when they host Sandwich. Originally set for a 7 p.m. start, the game has been pushed up for a 5 p.m. kickoff.
You think John Boehner had a rocky time as speaker of the House? Just wait until you see how his successor fares this fall — if House Republicans can even find a successor.
Five-foot-eight running back Dion Lewis says his two-year contract extension with the Patriots won't change his approach one bit. Three games into his career with the team, Lewis has totaled 325 yards from scrimmage
Contrary to popular belief, President Obama does have a plan for Syria. It's just not one that promises to have much immediate impact on the course of the brutal civil war.
If it had the wit, the Obama administration would be not angered, but appropriately humiliated. President Obama has, once again, been totally outmaneuvered by Vladimir Putin. Two days earlier at the United Nations, Obama had welcomed the return, in...
SouthCoast Directory
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What is the one thing you would love to do? Is it something you do now? Or just something you dreamed of being before the mom days?
My dream job is to be a CSI or work in a crime lab. I did go to school for CJ but did not finish. I have been thinking about going back after the kiddos are in school full time(one more year!) but I am not sure yet.


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I'm not worried (yet) as I suspect it is related to pregnancy since it appeared after my breasts grew. Anyone with anything similar? If it's still here at my next appt, I will have it looked at more thoroughly.
Married 4/4/05
First baby boy Victor 8/6/10
I have had swollen lymph nodes in my armpit previously due to stress but they typically go away within a few days. I would recommend calling your OB if it doesn't go away in the next week to ask for a script for the ultrsound because God-forbid it could be the first sign of breast cancer which they typically recommend treating during pregnancy.
Married to David - 8/11/07
Mommy to Simon Peter - 4/15/11
Faith Laura - 8/10/13
Mommy to Delaini, 3 and Bailie, 2 and expecting our Rainbow baby in August 2013 after two MMC in 2012!
Renee ~Xane 11y ~Kai 7y ~Ace 5y ~Declan 3y ~ Phoebe 8/27/13
Mommy to 3 daughters. 9, 7, and 5 years old. Expecting a baby in Aug 2013
Wow! I noticed a lump in my armpit too. I noticed mine a week before I found out I was pregnant. It came with some discomfort to, so I thought it may have been hair growing under my skin. I noticed the lump comes and goes. I told the midwife I saw a few days ago about it and she didn't really take any interest in my concerns. But now I'm a little more concerned now.
D(29)&T(23) married Nov. 14 2012
Mommy to Aedan 5 y.o.
Lil Ellie Due Sept. 12th!


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Elmhurst is a middle class neighborhood in the New York City borough of Queens in the United States, on Long Island. It is bounded by Roosevelt Avenue on the north; the Long Island Expressway on the south; Junction Boulevard on the east; and the New York Connecting Railroad on the west. The neighborhood is part of Queens Community Board 4. [ - ]


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Swarovski Crystal "Butterfly" Pink Crystal Pendant Necklace. 14.75"
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This "Butterfly" pendant necklace from Swarovski captures the soft, delicate nature of the insect. Pink crystals are set with the Swarovski exclusive "Pointiage" technique upon a romantic open frame. Suspends from a cable chain with a lobster clasp. Gold plate pendant necklace.
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What is Robben Island like, that dreaded prison we have heard so much about? What is the island really like?
(Naidoo and Sachs 2000:48)
The prison is above all punitive, it operates to break the human spirit, to exploit human weakness, undermine human strength, destroy initiative, individuality, negate intelligence and process an amorphous, robot-like mass. The great challenge is how to resist, how not to adjust, to keep intact the knowledge of society outside and to live by its rules, for that is the only way to maintain the human and social within you. …
Nelson Mandela (quoted in Hutton 1994:55)
Robben Island, the place where Nelson Mandela and his colleagues were imprisoned, is perhaps one of the best-known cultural heritage sites in the world today (Fig. 23.1). On 1 December 1999 at a meeting in Marrakesh, the island was inscribed as a World Heritage Site 1 in recognition of its outstanding universal value to mankind, having already been designated as a national monument. Designation and inscription are only the beginning of a management process, however, which poses the dilemma of how best to conserve the place in a way which retains its significance and yet at the same time caters for the hundreds of thousands of people, both local and international, who want to visit. More imporantly, in the longer term, sites such as Robben Island may force us to re-examine traditional models of heritage management which have been developed in Europe.
Significance lies at the heart of this heritage project. Robben Island is an extremely complex place in heritage terms because it represents a mosaic of significance to many different people at different levels and for different reasons. On the one hand, it is of international significance for its association with Nelson Mandela and his colleagues; on the other it is typical of a number of prison islands - Alcatraz, Rottnest off Freemantle, the isthumus of Port Arthur, St Helena - which are of


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Cowboys Photos
Our favorite photos from Dallas Cowboys training camp
Photo: Vernon Bryant/Staff Photographer
Block party. Cowboys cornerback Morris Claiborne (right) and running back Lance Dunbar (center) block defensive back Micah Pellerin on a special-teams play during a walkthrough.
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The London Carriage Works, a multi award winning restaurant.
Six courses and five Champagnes - £120
From festive lunches, dinners and afternoon teas to party nights and New Year's Eve!
12noon - 4pm - All welcome.
Click below to download our Festive Brochure.
Download our electronic booking form here>
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Choose one of our favourite recipes from our How To Recipe Range.
Click the link below to find out How To...
Make pan roasted wild Scottish halibut with English risotto >
Make pan roast loin of pork >
make John Dory with Southport samphire, Claremont Farm asparagus... >
Make the perfect scone >
Make pan roasted fillet of John Dory >
The London Carriage Works is a multi award winning restaurant serving modern British dishes complemented by the use of local, fresh and seasonal produce.
The London Carriage Works acquired its name when during external renovation works the original company name became apparent in the stonework. The company was a coach and carriage builders and built around 1866 in a pervading fashion of the day, the Venetian palazzo.
The restaurant is sister to hope street hotel and is open to the public seven days a week, from breakfast to nightcaps, with lunch, afternoon tea, supper, dinner and cocktails in-between. In house we also cater for many varied events from wedding suppers to meetings and corporate dining.
Fill in your details below to let us keep you up-to-date with the latest offers, news and events going on at The London Carriage Works.
'Hope Street Hotel is a fine example of the genre'. The Sunday Times
'Isambard Kingdom Brunel meets Carrie Bradshaw'. 10/10. The Sunday Times
'It's handsome, sleek, daring and not what you would have found in Liverpool two years ago'. The Sunday Telegraph
Visit hope street hotel for more information and sign up for our regular newsletter for the latest news and event details.
The London Carriage Works
Hope Street,
0151 705 2222
© Copyright Hope Street Hotel 2009. All rights reserved.
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If you want to stay abreast of what's happening in custom software development
Thursday, January 24, 2013
There has been an increasing number of cybercrimes over the past three years – particularly in espionage and cyber hacking. According to the Ponemon Institute*, an American organisation that conducts research on data protection and security, cybercrime has more than doubled over the last three years and the financial impact of these attacks has increased by almost 40%. In Australia alone, it is estimated by Symantec that cybercrime has cost Australians $1.65 billion in 2011. In the Norton Cybercrime Report 2012**, Symantec reported that cybercriminals were increasingly setting their sights on mobile platforms.
Although large enterprises, hosting providers and even government departments have been the victim of cyber-attacks over the past year, as often documented in the press, many targets have been small and medium-sized enterprises. The cyber-attacks carried against small and medium-sized enterprises have usually been the theft of financial data such as credit card details. With simple security measures in place, 90% of these crimes could have been prevented. However, it is taking many organisations up to seven months to detect a breach of their system.
On the overall scheme of things, financial crime has actually fallen in comparison to cyber hacking and espionage which have increased over the past year. Such crimes are usually carried out against large enterprises. Login credentials were a particularly commonly targeted vulnerability where 74% of cyber-attacks have targeted remote access entry points. With the increasing popularity of the BYOD (bring-your-own-device) initiative where employers are permitting their employees to use their own devices at work to access company data, what measures can an organisation take to ensure that if they offer employees the ability to access company data remotely, that these entry points are secure?
According to Craig Moore, Solentive Software's Lead Architect, the rapid development and adaptation of mobile computing platforms, from laptops to tablets and smart devices is placing increased pressure on organisations, both big and small, to support remote computing if they want to stay competitive in an increasingly tight market.
"A large portion of companies who have fallen victim to cybercrime are usually running legacy remote access frameworks designed to manage corporate devices such as SOE (standard operating environment) laptops and old smartphone models. These devices are not equipped to manage today's remote access needs and cannot be adapted. The use of these devices has led to increased exposure of corporate infrastructure and digital assets as access points are opened around the existing infrastructure to support short term needs," explained Moore.
"Remote access is quickly taking precedence over the provision and maintenance of adequate security in the rush to keep up with efficiency demands. However, performing the two does not have to result in large scale expenditure. Rather, they can be achieved by taking the time to understand the remote access needs of the business," continued Moore.
The following should be taken into account when developing a viable security solution that satisfies the core needs of the business:
However, Moore points out that the most important point is to educate your users.
"Do not assume that they will follow your policies just because you sent them an email to say that they have to. It is important to help them understand what you need them to do in simple terms and why. Any breach in security or cyber-attack is almost always initiated by the action of a user," concluded Moore.
* Rawlinson, K; & Doss, M., HP Research: Cybercrime Costs Rise Nearly 40 Percent, Attack Frequency Doubles, October 2012 – (Hewlett-Packard)
** 2012 Norton Study: Consumer Cybercrime Estimated at $110 Billion Annually, September 2012 – (Symantec)
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UNSW Global partners with Solentive
Foxtel selects Solentive
Phone: 1300 55 30 50
E-mail: firstname.lastname@example.com
Or fill in the form on our contact page


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Mora out as Seahawks coach...after one season. Not that anyone really cares...
Seattle Seahawks fire Jim Mora after one season, source says - ESPN
Yep, don't care about Mora.
Dumb decision to make him coach in waiting when Holmgren was there anyway.
College Football Analytics on Twitter & Facebook
Wide Right & Natty Lite - Loyal Sons, Forever True. With beer!
His death knell was probably OKing the neon green alt jerseys:
In full disclosure, I'm probably the only person that actually liked those uniforms.
Originally Posted by cardinal&gold
His death knell was probably OKing the neon green alt jerseys:
In full disclosure, I'm probably the only person that actually liked those uniforms.
If they were wanting to wear an alternate uniform...why didn't they just go back to the Jim Zorn/Steve Larget/Dave Kreig unis? Those were very cool!
He couldn't win in Atlanta at a high level. I don't know why they thought he could be a winner in Seattle with worse players.
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