text: Ten Steps to Greener Sex From recycled bikinis to fair trade condoms By Lev Weinstein, Newser Staff Posted Jun 26, 2008 11:32 AM CDT STORY COMMENTS (0) (Newser) – Eco-conscious sex certainly doesn't have too enticing a ring to it, but don't discount the enjoyable ways to spice things up while doing your part to save the Earth, says Greendaily.com. From the reasonable to the wacky, they've got you, er, covered: Grab French Letter condoms, the world's only fair trade rubber Clean your place—add eco-friendly mood lighting Use sex, not aspirin, to make that migraine go away Go cyborg, with a sperm-blocking microchip Munch on pomegranates—the natural Viagra Eco-Friendly lingerie: not ugly or uncomfortable, we promise Use solar-powered sex toys. Not outside, stupid. They're chargeable. Visit Heidi Fleiss' wind-powered brothel Get a sexy Victoria's Secret swimsuit made from recyclables Use enviro-friendly heat-sensitive panties, printed with organic inks. Former Hollywood madam Heidi Fleiss plans to open the world's first wind-powered brothel. (AP Photo/Melbourne Age, Angela Wylie) Model Yuko Ishida displays a "solar-power generator bras" presented by lingerie maker Triumph International Japan Ltd. during a press unveiling in Tokyo Wednesday, May 14, 2008. (AP Photo/Katsumi Kasahara) ADVERTISEMENT(Click Prev or Next to continue viewing images.) « Prev« Prev | Next »Next » Slideshow Green Daily (Source Grid ») Site of Enamore, green lingerie makers Enamore Lifestyle green energy • safe sex • green technology • sex toys • sexy costumes • sexual revolution • green products • Heidi Fleiss To report an error on this story, notify our editors.


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Updated 03/13/2015
Sosúa is not a destination known for its sights. However, this museum stands as one of the exceptions, chronicling the immigration and settlement of the Jewish refugees in the 1940s. This is a fascinating place, and depending on the docent, you may hear that the Jewish settlers fleeing from Hitler, experienced a certain amount of prejudice here when they arrived
The fascinating website says no. The adjacent small wooden synagogue is the wedding spot for many Jewish couples from abroad. At this writing there wasn't a working telephone and hours were irregular, but chances are good that someone will be at the museum to let you in if you get there early in the day. You can try phoning Sosua Villas or the accommodating Hotel Casa Valeria nearby to confirm if the museum is open.
Near Banco Popular, Calle Dr. Rosen at David Stern, Sosúa, Puerto Plata, 57000, Dominican Republic
809-377–2038-Sosua Villas; 809-477–2038-Sosua Villas; 809-571–3565-Hotel Casa Valeria
Website: www.sosua-villas.com/jewish-museum
Sight Details:
Updated 03/13/2015
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Do You Save Old Food Magazines?
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JessRose 6 years
I save my Bon Appetit for 1 whole year in an archive magazine box on the book shelf - and then in January of the next year, I go through them again and decide which ones I want to save into the next year and which ones (that I've never used) get tossed out. Works great!! :)
Spectra 6 years
I keep all my Bon Appetit and Everyday Food mags as handy recipe guides. They come in really handy sometimes.
Food 6 years
Yes -- so unfortunately, my house looks like a periodicals library!
elw722 6 years
I have piles of old food magazines that I have kept and still go back to. After publications like Williams-Sonoma's Taste and (the beloved) Gourmet magazines ceased publication I am glad I kept them all :)
Daisy-Duke 6 years
I flag the recipes I want to make and keep them with my cookbooks. I'm getting WAY too many though, so I had to stop subscribing!
PinkUnicorn 6 years
Not only do I save them, but every few months I go through all of them and cut out the recipes I like. Then I take the recipes and put them into photo albums (the kind with the sticky sheets covered in clear plastic) and sort them into groups, i.e. appetizers, vegetarian, desserts etc. I have already filled two of these!
pink-elephant 6 years
I'm sure we have a secret stash growing somewhere.
LilGlamDiva 6 years
My grandmother used to have piles and piles, and I would always read them and photocopy what I l liked and keep it in a binder. When I subscribed, I kept the ones that had things I actually wanted to make, otherwise I would chuck them because they would take over my home.


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Shabbat – An Island in Time
Jewish Essentials - Part 2Beginner
Topics: Shabbat
© Copyright, all rights reserved. If you enjoyed this article, we encourage you to distribute it further, provided that you comply with Chabad.org's copyright policy.
Discussion (20)
February 11, 2015
Beautiful, beautiful, beautiful !
I am not a jew. I´m interested in your knowledge which
really gives meaning to my life.
The perspective, the explanations given, everything is so in
its place, everything happens for a reason, awareness, responsibility,
everything , every word becomes alive.
Thank you for sharing. It is a blessing.
I am not a jew. I´m interested in your knowledge which
really gives meaning to my life.
The perspective, the explanations given, everything is so in
its place, everything happens for a reason, awareness, responsibility,
everything , every word becomes alive.
Thank you for sharing. It is a blessing.
November 2, 2013
God is doing avante-garde things still
This presentation was very informative; giving an over-all picture. I am not jewish. I do appreciate the perspectives you gave, very meaningful on many levels. :)
April 18, 2012
As I sit
As I sit and stare out of my one room home I have the hope that my oasis ,my rest will appear .I see all Jews sitting at the calm beaches of the sands of time on Shabbat. The word relaxing now has more meaning than ever, as when the words can come to peace of the Mitzvahs we have done.When the connection to HaShem is so clear yet we are not perplexed.When there it is no longer barriers between are actions and our thoughts which are pure kindness on this day.We are together we are one and HaShem has much joy that we now understand what is the past .Before we had scares of our own doing but healing is our strength. Problems in our lives help shape the good merit for our future.The waters are still and clean as well as our souls are pure and bright .I will no longer am just me,I will be what HaShem made me to be body and soul.
April 18, 2012
Please never stop telling these wonderful messages. It is the very best part of my day.
Ms. Whitney Metts
March 4, 2012
good lecture,10/10!
March 2, 2012
my soul
thank you...
thank you...
baytown, tx/usa
baytown, tx/usa
January 11, 2012
Rabbi Shlomo Bistritzky is very thorough and has greatly helped in answering some of our question on how to start and continue a kosher home and a jewish traditions.
Marat Dreyshner
richmond, canada
richmond, canada
December 21, 2011
I did learn today a very important lesson.
Thank You!!!
Thank You!!!
Patricia Ardavin
Alpharetta, GA, USA
Alpharetta, GA, USA
April 25, 2011
Truly enjoyable
Rabbi Bistritzky I really enjoy listening to your lectures. The stories are wonderful and the presentation of material is easy to understand and highly engrossing. Thank you so much for sharing your wealth of knowledge. I now have a greater understanding and new found appreciation of Shabbat.
Aimee Carter
Salt Lake City, UT
Salt Lake City, UT
September 1, 2010
Thank you for this spiritual bread. How wonderful and easy to learn when one opens the eyes of the spirit. This is eternal wisdom to transform lives not only mine but others. Thank you again.
felipe de jesus zamudio alejandre
Queretaro, Queretaro,Mexico
Queretaro, Queretaro,Mexico
- Vayoishah (0:59)
- Shabbat Audio Classes
- Shabbat
- The Holiness of Shabbat (40:40)
- Shabbat Songs
- Lamnatzaich (1:08)
- Keeping Shabbos (3:01)
- Shabbat (709)


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One legacy of the 2012 presidential race: the super-political action committees it spawned. Weeks after the Nov. 6 election, those groups still had more than $5.4 million left to spend, Federal Election Commission reports due yesterday show. Each candidate —...Read more »
Super-PACs Still Super With $5.4 Mln — Though `9-9-9′ Down to Last $100
2012 Elections Cost Will Hit $7 Billion, FEC Chair Weintraub Says
The 2012 elections will be more expensive than originally thought, according to new Federal Election Commission Chairwoman Ellen Weintraub. Her estimate: $7 billion. That's higher than the $6 billion estimate from the Center for Responsive Politics, a Washington-based research group...Read more »
Obama Re-Election Behind Him, Burton Joins Consulting Firm
Former White House aide Bill Burton is joining the Global Strategy Group as executive vice president in its Washington office. Burton is co-founder and senior strategist for Priorities USA Action, a super-political action committee that helped re-elect the president. Burton has "a...Read more »
Giffords Gun-Control Packs Texan Cash: Trial Lawyers in for $1 Million
Steve and Amber Mostyn, wealthy Texas trial attorneys, said today that they are giving $1 million to help start the gun-control advocacy group formed by former Arizona Rep. Gabrielle Giffords and her husband, astronaut Mark Kelly. Steve Mostyn, one of...Read more »
Bloomberg by the Numbers: $97.7 Million
That's how much outside groups spent in the final week of the Nov. 6 election campaign, according to the Center for Responsive Politics. The big late spenders included American Crossroads ($23 million), a super-political action committee founded with help from...Read more »
Bloomberg by the Numbers: $2.23 Bln
That's how much President Barack Obama, Republican Mitt Romney and five groups active in the presidential election raised from Jan. 1, 2011 through Nov. 26, 2012. Obama and two Democratic groups together raised $1.10 billion, compared with $1.13 billion raised...Read more »
Bloomberg by the Numbers: 1,014,484
That's how many times television ads from President Barack Obama, Republican nominee Mitt Romney and other groups involved in the Nov. 6 election have aired during the general election campaign, according to Kantar Media's CMAG. The totals include spots that...Read more »
Wrong Walton, Priorities USA Action Declares
Priorities USA Action, the super-PAC supporting President Barack Obama, incorrectly told the Federal Election Commission that Wal-Mart Stores Inc. Chairman Samuel Robson Walton, better known as Rob, was a $300,000 donor to the group last month. In an amended FEC...Read more »
Priorities Sets New Priority: Nevada
Priorities USA Action, a super-political action committee backing President Barack Obama, is shifting and increasing its television advertising buy to include the swing state of Nevada, its co-founder Bill Burton said this morning. The super-PAC's new focus on Nevada, which...Read more »
Soros: $1 M for Obama-Backing Super-PAC
Investor George Soros, a long-time donor to Democratic candidates and causes, has agreed to contribute $1 million to the super-political action committee run by former aides to President Barack Obama. Two officials of Priorities USA Action confirmed the donation. Priorities USA...Read more »


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June 8, 2012
-submitted by April Frayer/ Jordan Frayer, New Boston Huron graduate. He is attending Adrian College and will play on the baseball team. Pictured with his brother Jeremy
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Cherry Blossom by Li-SoroWatch
©2013-2015 Li-Soro
Acrylics on canvas.
Original photo by Raylau raylau.deviantart.com/, reference: raylau.deviantart.com/art/cher…
Original photo by Raylau raylau.deviantart.com/, reference: raylau.deviantart.com/art/cher…
WOW!!!! How long have you been painting and drawing???? What helped you the most to CAPTURE the REALNESS of the subjects you paint?
That's so lifelike and pretty! Very impressive!!
Thank you Luiza! I really like your photo of sakura too!
Wow...! That's so wonderful, what a wonderful paint! That's when I saw it was from Traditional-Painting than I realize "That's a painting?!" I look at if closer and I understand how it's look so real! That's fantastic! Really well thought!
My mom watch is and she found it incredible too!
My mom watch is and she found it incredible too!
Aww, thank you and your mother for the attention to my painting! I am touched!
Wow you are a great artist. I like how flower fade a little out of focus. Keep up the wonderful job!
Thank you so much! A big compliment to me. Thank you for noticing the fading thing - it took me ages to do it. So I am glad it looks good
Keep came out great so it was worth spending time on the fading. I'll see more of your work soon!
This is perfection!
A beautiful painting based on a beautiful photo! The realism you achieved here is stunning. I love the way you made the distant buds look more fuzzy and out of focus, like the photo. The resulting depth is very yummy. Fabulous work!
Thank you very much! I really appreciate a detailed feedback! Thank you for compliments too! ^_^
Beautiful ! nice soft background
nice painting!
Love it.
So nice!


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Police have arrested a tenth person following last week's death of the soldier Lee Rigby in Woolwich as193 anti-Muslim incidents are reported since last Wednesday, including 10 attacks on mosques.
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If the Vintage Truck of Style crashed headlong into the Bullet Train of Edgy, the result would be the basis for the Oakley Deuce Coupe Frogskin Sunglasses. Share your absurdly good looks with the world with the assistance of these simultaneously retro and progressive shades, every bit as functional as they are fashionable.
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India's recent historical development as an incubator for makeshift online entrepreneurs is nothing new. It's recent willingness to interact with major American e-commerce powers? That's something else entirely. With major legislative changes on the horizon, 2014 could very well be the year when India receives funding and investment from global players. Here's a brief run-through of why one of online businesses' biggest players is looking to tear down walls and build international unions.
Foreign Direct Investment (FDI) in B2B e-commerce has existed in India for years, and American e-com giants like Amazon and eBay already possess footholds in the country through online marketplaces, though these opportunities represent the only option for foreign involvement in the industry. B2C e-commerce is currently illegal in India, leaving a population of 1.2 billion potential shoppers off-limits to outside businesses. Upcoming changes to B2C legislation, however, could eliminate the red tape separating foreign investors from the second-largest population in the world.
Amazon broached the subject of relaxing FDI bans in e-commerce with the Indian government last November, but neither party announced official plans moving forward. As e-commerce holidays in the United States stole the international limelight, the talks were largely forgotten until media hype resurfaced in recent weeks. But the news was worth the wait.
According to the Business Standard, FDI could be allowed into India as early as April. With an open, e-commerce India only months away, understanding the allure of Indian e-commerce is key. Its global power can be traced to two factors: runaway financial gains and the exponential growth of Internet users.
E-commerce in India boasts the fastest industry growth in the Asia-Pacific region. While the final numbers are still rolling in, India's e-commerce industry in 2013 was estimated to be worth 16 billion USD – an astonishing 88% increase since 2012. (To put it in perspective, e-commerce in the United States grew by less than 15% from 2012 to 2013). The industry shows no signs of slowing down, as Internet penetration in India passed 10% in 2013 and only continues to grow.
India expects its population of Internet users to reach 243 million by June of this year, thereby dethroning the United States as the second-largest, Internet-using population after China. And, unlike China's aging population, India's youth-heavy population contributes to its success. Three out of five Internet users shop online, and nearly 90% of all online shoppers fall into the 18 to 35 age range.
Relaxed FDI legislation coupled with rapid industry growth and a booming, Internet-using population cements the country as the key to expansion in e-commerce. What's this mean for any e-commerce company? Keep your eyes peeled for an opportunity to both invest and sell in a marketplace where online business is on the verge of skyrocketing.


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Blue Belt Technologies Resolves Lawsuit Business Wire PITTSBURGH -- April 4, 2013 Blue Belt Technologies, Inc. ("Blue Belt") today announced that it has resolved a lawsuit filed by MAKO Surgical Corp. ("Mako") of Ft. Lauderdale, Florida. The suit asserted breach of contract and various unfair competition claims, all of which Blue Belt vehemently denied in its court filings. Blue Belt manufactures and markets the NavioPFS orthopedic surgical system with precision robotics for unicondylar knee replacement (UKR), commonly known as a partial knee replacement. NavioPFS offers significant advantages over other robotic-controlled systems available in the marketplace, including Mako's system. Unique differentiating features include image free navigation, an open platform for implants which allows physicians to use their preferred type of implant, and a handheld smart instrument with robotic control. These advantages are all offered at a price point that makes precision robotics available to hospitals of all sizes, including outpatient surgery centers. Blue Belt received FDA clearance for NavioPFS last November and formally launched the system at the American Academy of Orthopedic Surgeons annual meeting held in Chicago, March 20-22, 2013. "We believe that this lawsuit was without merit and Mako failed to prove that Blue Belt engaged in any wrongdoing. In fact, Mako failed to substantiate many of the allegations it made in its complaint and we are confident that Blue Belt would have prevailed had the litigation continued," said Blue Belt President and CEO Eric Timko. "At the same time, however, Blue Belt determined that it is in our best interest to compete with Mako by selling our new robotic technology in the marketplace, instead of competing in the courtroom, where no surgeon or patient can benefit. We have established great momentum since officially launching NavioPFS in the United States. We fully expect to continue rapidly expanding our presence in the marketplace as more physicians and hospitals see the benefits that NavioPFS can bring to their patients and facilities at an economically friendly price point." Blue Belt Technologies, Inc. Blue Belt Technologies, Inc. has developed the next generation of "smart" surgical instruments with precision robotics for use initially in orthopedic procedures and then for other surgical specialties, including neurosurgery, spinal and otolaryngology (ENT). The company's NavioPFS System incorporates patented technology to provide precise robotic control to surgeons via an intelligent, handheld, computer-assisted bone-cutting tool. The NavioPFS System provides the surgeon with a layer of safety and enhanced accuracy while performing bone-shaping tasks through less invasive incisions. More information about Blue Belt can be found at www.bluebelttech.com. Contact: ML Strategies, LLC Nancy Sterling, 617-348-1811 firstname.lastname@example.com
Blue Belt Technologies Resolves Lawsuit
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Though linebacker Brandon Chillar hasn?t been a starter in the Packers' base defensive package, he's considered a vital piece to their defense because he?s so heavily involved in their sub packages. File/Gannett Wisconsin Media
The Green Bay Packers finally made a dent in their long list of potential free agents on Monday, when they signed linebacker Brandon Chillar to an extension.
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Chillar, who was among a dozen veteran Packers players whose contracts are set to expire after this season, agreed to a four-year, $21 million contract extension that will pay him $9.5 million between now and the end of next season, according to his agent, James Ivler. ...


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Tigertel Communications Inc. (Tigertel) is a Canada-based provider of outsourced call center and contact management services. Services provided by the Company iMore
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Re: where are they
According to http://wikitravel.org/en/Nanjing, "The area around Shanghai Lu, which runs between Nanjing University and Nanjing Normal University, has quite a few expats — mainly foreign students or English teachers from the two universities — and some places that cater to them. On Shanghai Lu near Guangzhou is "Blue Sky", an Aussie-owned bar with good music and a free pool table. Moving North from there, the Behind-the-wall Cafe with reasonable Mexican food and good music is just off Shanghai Lu and one location of Jack's, for good Italian food, is on the last corner before Beijing Lu."
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This is the true story of a woman, who having had been away from the lord for forty years , one night went to sleep and had an out of body experience, A skeptic in search for answers. When a Second out of body experience happened, she knew time was running out. This is the story of A Second Chance, A Spiritual Experience that transformed her Life.
on Myrna-Quiles


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My son seems not too be satisfied with breast milk anymore. Cos every now and then he's latched on. And it's kinda tiring for me. He is 5months old today. I plan on introducing solids this month. What do you all think? And any suggestions on solids I can start with?
help! is my son eating too much?
Posted 01/16/2014
Comments (3)
Posted 01/17/2014
We did oatmeal for about 2 weeks, then sweet potatoes, then avocado and today I'm going to make apples. My son has no interest in the oatmeal anymore which is fine by me.
Caden 7/31/13
Caden 7/31/13
Rylan 5/26/15
Posted 01/21/2014
DS is 5 mos and has been eating food for a month now. I skipped cereals altogether. Started with avocado. Since, he's had apples, bananas, peas, and peaches. All home made.
Posted 01/21/2014
We started with applesauce. He's been on them since about 3 1/2- 4 months.He will be 6 months on the 12th.
Love my Butter Bean!!!


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Sounds Like: NOFX - Official Page, Pennywise, The Ramones, The Business, Cockney Rejects
Label: Las Vegas Punk Rock Scene
Bio: Sin City? Maybe, maybe not. Stainless Steel Ride is a band that represents the darker and dirtier side of Vegas. From the mean streets to sleazy penthouses, from the trailer park to the sex clubs, songs about sex toys, hard times, violence, alcohol, and scandalous people are the foundation of a t...See Full Bio


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The CMHC sequenced curriculum begins in summer semester. Applicants are encouraged to apply for summer admission. Students applying for fall or spring admission take non-core classes until they joint a cohort that forms the following summer semester.
This is the home page for the Master of Science program in Counselor Education with an emphasis in Clinical Mental Health Counseling at the University of South Alabama.
The Clinical Mental Health Counseling (CMHC) program is a 60 semester hour degree designed to prepare professional counselor to work in a variety of mental health settings. The program is designed to meet the graduate degree standards for licensure as a Professional Counselor in the state of Alabama. A core focus of the CMHC program is training in basic and advanced counseling/psychotherapy skills as well as psychosocial assessment, case conceptualization and treatment planning. Students also receive training in mental health program research, development and evaluation. Throughout the program curriculum training is anchored in culturally competent counseling practices and evidence-based counseling paradigms.
The program is housed in the Department of Professional Studies, which is within the College of Education at the University of South Alabama. The program admits students each semester. During the program students complete coursework as well as a 700 hour clinical field experience. Please click on the links in the sidebar on the left side of the page to find out more detailed information about the CMHC program.
The CMHC program became CACREP-Accredited in July, 2014.
CACREP (The Council for Accreditation of Counseling and Related Educational Programs) is an independent accrediting body whose mission is to advance the profession of counseling by developing standards, encouraging peerless quality, and accrediting preparation programs.
CACREP accreditation provides assurance that a program has been thoroughly evaluated to meet the standards necessary to produce competent counselors. CACREP accreditation also confers greater ease in state licensure. Some states require credentialing, and in others it is voluntary but advantageous.
Please visit www.cacrep.org for further information regarding accreditation processes, and the Department of Counselor Education for more information about our programs.


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PREIT Schedules Webcast for Upcoming Investor Conference on November 8, 2012 Business Wire PHILADELPHIA -- November 07, 2012 Pennsylvania Real Estate Investment Trust (NYSE: PEI) announced that it will hold a live webcast for its Investor Conference on November 8, 2012 at The Hub at the Cira Centre in Philadelphia, Pennsylvania at 8:30am ET. As previously announced, this event, held for investors and analysts, will feature visits to some of the Company's local properties and provide presentations from Joseph Coradino, PREIT's new Chief Executive Officer as well as other members of PREIT's leadership team. A live webcast of PREIT's presentation will be available at the Company's website, www.preit.com, and at https://viavid.webcasts.com/starthere.jsp?ei=1010274. An online replay will be available for up to one year after the event. About Pennsylvania Real Estate Investment Trust Pennsylvania Real Estate Investment Trust, founded in 1960 and one of the first equity REITs in the U.S., has a primary investment focus on retail shopping malls. Currently, the Company's portfolio of 49 properties comprises 38 shopping malls, eight community and power centers, and three development properties. The Company's properties are located in 13 states in the eastern half of the United States, primarily in the Mid-Atlantic region. The operating retail properties have approximately 33 million total square feet of space. PREIT, headquartered in Philadelphia, Pennsylvania, is publicly traded on the NYSE under the symbol PEI. The Company's website can be found at www.preit.com. Contact: Pennsylvania Real Estate Investment Trust Robert McCadden, 215-875-0735 EVP & CFO or Heather Crowell, 215-875-0735 VP of Corporate Communications and Investor Relations
PREIT Schedules Webcast for Upcoming Investor Conference on November 8, 2012
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text: Is George's Clooney's New Relationship Just A Trivial Pursuit?Margaret Hartmann and 24 othersEditDeleteInvite manuallyPromoteDismissUndismissBlock for jezebelHide George Clooney is dating a semi-professional game show contestent who goes by either Katie, Kate, or Stephanie Moeser. There are videos of Moeser in action on The Price is Right and Trivial Pursuit. [TMZ] »1/29/09 7:30pm1/29/09 7:30pm


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Creating letter-shape patterns #2
In this early writing worksheet, your child will trace, complete, and practice drawing three sets of line patterns that are used to form letters of the alphabet.
Drawing, Early writing practice, Left to right, Tracing
This worksheet originally published in English Made Easy Preschool Early Writing for ages 3 to 5 by © Dorling Kindersley Limited.
Common Core Standards: Kindergarten Reading: Foundational Skills, Kindergarten Language
CCSS.ELA-Literacy.RF.K.1, CCSS.ELA-Literacy.L.K.1


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Kim Snyder, President Kodaks Entertainment Imaging Division Vice President of Eastman Kodak Company addressing the rumors:
Kim Snyder, President Kodaks Entertainment Imaging Division Vice President of Eastman Kodak Company addressing the rumors:
I hope they mean what they say. The photography world wouldn't be the same without Kodak. I hope that they stick to it for the long haul, and that the investment in future-proof technology pays off enough for them to continue R&D
Yes, and comical-Ali also said something like
"The americans are dyiiing.......runiiing in they tanks, away from the Iraqi army as we speak"
"Do noe be afraid my friends, you are safe here with me".
We saw where that ended :)
I began working closely with Kodak reps in 1978. This is the same 'film is here to stay, film will never die' rap they were spinning then, updated for 2011. BTW, using 'always' and 'never' in an argument is a sure sign of eventual failure.
Although it may be coated on the same machines as the film we are all interested in, this PR blurb only addresses the continued production of MP film. Of course they will produce that while ever there is a market because it is made in vast quantities. I also believe they will continue to make RA4 paper for a good while yet because there is a big market for it too, mainly to print digital snapshots! All of this, however, is no guarantee that Kodak will continue to make sporadic short runs of consumer/professional film. If you haven't done so, read elsewhere here on APUG about the confirmed demise of PlusX in recent days and EKs reasons for dropping it - basically not enough demand to justify coating any more of it. OzJohn
as sidebar... I requested Kodak to make a special order of 5,000 rolls of film... they couldn't take the order, even though they had all the technology... their suppliers couldn't supply them. Some had gone out of business...
when the river dries out, when local manufacturers disappear, ... certainly you can see the tree falling in these woods.
Under the present circumstances, can Kodak even pay its suppliers?
Well they could sell their canadair challengers 604 would net them about the same amount of money as the Imax deal 8 - 13 Millions times two. to pay their suppliers. I personally hope that they don't have to and that the pilots will keep their jobs for a long time.


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State leaders like smokers' money
Regarding "AG rules cities can't ban smoking in parks" (News, Feb. 12): I'm happy to see Attorney General Scott Pruitt standing for the liberties of 26 percent of Oklahomans against Gov. Mary Fallin, state Health Commissioner Terry Cline and other anti-smoking zealots. Fallin claims to be a conservative but has no problem forcing her will on our citizens and taking away liberties she has no authority over. One of her first acts as governor was to close the smoking area at the state Capitol, which did nothing but let smokers know she doesn't approve of their behavior. In the name of public health, people like Fallin try to shame smokers into behaving as they deem acceptable. This is a liberal tactic.
I was associated with a drug and alcohol treatment center when Cline banned smoking at facilities that got state funds. It's hell to see someone detoxing from narcotics or alcohol who can't have the small relief offered by being able to light up. But that didn't fit Cline's agenda.
I agree with Sen. Brian Crain, R-Tulsa: If you want to talk about banning tobacco, do it. Otherwise, quit trying to force your will and judgment on others. This will never happen because Fallin and other big-government RINOs (Republicans in Name Only) still want funds from the tobacco settlement, which comes from the 26 percent she's trying to shame. They like smokers' money, but they don't like their behavior. Hypocrites!
Stephen Butler, Yukon
The attorney general's opinion says municipalities can't restrict smoking in public outdoor areas because state law bans cities from passing smoking laws that are stricter than state law.


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We are no longer accepting applications for the 2015 Miss Dyngus Day pageant. We have already selected the contestants.
Miss Dyngus applicants must be present for
Applicants will be called upon to perform Dyngus Day Miracles one after another.
Kim Hanko-Dale (aka - Hankodaleski) was crowned Ms. Dyngus 2014. Kim has played a key roll in bringing polish tradition and polka music back into her family. Last Easter Kim and her husband, Jonathan had the entire family dancing to polka music while sipping cytrynówka. Kim and Jonathan traveled to Poland on their first wedding anniversary to prepare for the 2014 Ms. Dyngus Day pageant. Her family has always referred to her as the Polka Princess, and being crowned Ms. Dyngus proves it. She couldn't be more proud when her nephew calls her Auntie Dyngus. Kim's favorite polka is Hoop Dee-Doo because the lyrics "I hear a polka and my troubles are through" couldn't be more true.
Julie (Kocurko) Bray is Ms. Dyngus Cleveland 2013. When asked what drew her to apply for Ms. Dyngus, she knew it would be great fun and would make her grandparents, Walter and Julia Zurowski, smile up in heaven. Her qualifications include, but are not limited to, pierogi & borscht making, polka dancing, and let's face it; she looks damn good in a babushka. With the help of her family, they make over 500 pierogi each fall just in time to eat for wigilia. When she isn't pinching pierogis, you may find her practicing her lines for next years How the Kishka Saved Christmas performance, spending time with her husband and their little golumpki (aka her children), running, or drinking piwo.
DeAnna Domino-Sierputowski won the 2012 crown with her campaign slogan "A pierogi in every pot and a polka in every heart." She is Cleveland born and bred, and currently resides in Tremont with her Polish Prince, Jeffrey Sierputowski, and their polka loving cats. She believes polka makes everything more fun, even cleaning! It would be rare to catch her scrubbing the toilet without a polka record playing. Her travels through Poland are some of her most cherished memories, though even that pales in comparison to the Dyngus Day crowning ceremonies. It was a proud moment for both her and her Polish family when she won the 2012 title. Her favorite polka is, and always will be, Ice Cubes and Beer.
The inaugural Miss Dyngus 2011 is Eugenia "Chi Chi" Gorski. Born and raised in Cleveland, she has been making pierogi since birth! She also holds the world record for the fastest polka ever at 78 revolutions per minute!


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The Adventure Spa Retreat Package
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Enjoy a welcome bottle of Champagne, truly restorative spa treatments, the Oasis Waterfall Lagoon, and authentic "spontaneous garden cuisine," with our Adventure Spa Retreat Package.
During your escape, you'll also be able to center yourself with daily Yoga, Pilates, or Tai Chi classes, hike the Sycamore Crest Trail or bike the Bob Jones Trail, discover the pristine beaches and village of Avila Beach, and explore our extraordinary wine country.
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Direct: 805.595.7302
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Heading into 2014, Adam Dunn isn't concerned about a more limited role or about being part of a three-headed monster at first base.
And he isn't concerned about his stat line, either.
As long as the White Sox produce a winner and Dunn goes to the postseason for the first time in his career, he doesn't care how it gets done. He believes as long as winning is the priority, the White Sox will determine how to divide up the playing time on a 25-man roster that features Dunn, Paul Konerko and Jose Abreu.
"It's been like that from Day 1, but especially now," Dunn said at SoxFest on Saturday afternoon. "That's the number one thing. I can't speak for Paul, but I'm assuming that's why Paul's coming back, and that's why I'm excited to get this thing started."
[MORE: Rick Hahn defends Robin Ventura's passion to fans]
While the division of labor isn't clear at this point, one aspect is: Abreu was signed to a six-year contract in the offseason to become the centerpiece of the team's lineup.
In order to expedite the Cuban first baseman's development, the White Sox intend to play him every day. That leaves the second spot to be divided up amongst Konerko and Dunn, who in 2013 played 126 and 149 games, respectively.
When Konerko returned on a one-year deal in December, the White Sox said the veteran would play against some left-handed pitchers and mostly pinch-hit. Konerko said Friday he believes his role would be much more limited than in the past. Dunn is expected to take most plate appearances against right-handed pitching, which figures to get him around 400 at-bats.
[RELATED: Adam Dunn proud of 'Dallas Buyers Club' despite Oscar snub]
No matter how the situation looks from the outside, however, Dunn thinks it won't be an issue. He and Konerko talked about the potential scenarios over the course of several phone calls this offseason before the team's captain re-signed with the White Sox in December.
"The good news is there's no egos, especially with me and Paul," Dunn said. "We talked about it when he was making his decision. Whatever is going to help us win that night, I know he's for it and I'm for it. That to me is a non-issue."
Dunn is headed into his 14th season in the majors.
Through 1,870 games played, Dunn has never reached the postseason, marking the 22nd most appearances in major league history without having made the playoffs. He could potentially move up to No. 12 on that list this season.
To illustrate how badly he wants a postseason appearance, Dunn said he would have been ecstatic in 2011 — despite the worst offensive numbers of his career — if the White Sox had reached the playoffs.
Dunn hit .159 with 11 home runs that season.
"The ultimate goal is to win the World Series, and if you don't give yourself that chance… You've got to get in the playoffs," Dunn said. "I don't care how good or bad, it's over and you didn't accomplish the goal. … If in '11 we would have made the playoffs, I would have been happier than anybody in the clubhouse."


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Zhang, Xiaochun MD*; Lin, Steven H. MD, PhD*; Fang, Bingliang MD, PhD†; Gillin, Michael PhD‡; Mohan, Radhe PhD‡; Chang, Joe Y. MD, PhD*
Departments of *Radiation Oncology, †Thoracic and Cardiovascular Surgery, and ‡Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Disclosure: The authors declare no conflict of interest.
This article was presented in part at the 2010 Annual Meeting of the American Society of Radiation Oncology, San Diego, California, October 31-November 4, 2010.
Address for correspondence: Joe Y. Chang, MD, PhD, Department of Radiation Oncology, Box 97, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030. E-mail: firstname.lastname@example.com
Current Address of Xiaochun Zhang: Cancer Center, Shandong Provincial Hospital, Jinan, China 250021.
Background: Cancer stem cells (CSCs) play an important role in non–small-cell lung cancer recurrence and metastasis. We sought to determine whether CSC-like cells respond differentially to proton and photon beam therapies.
Methods: CSC-enriched cells from paclitaxel-resistant human H460 and A549 cell lines were irradiated with the same relative biological effectiveness dose and analyzed for cell viability, clonogenic survival, apoptosis, cell migration, cell invasiveness, tumor sphere formation, and CSC markers. The intracellular concentration of reactive oxygen species (ROS) was measured before and after irradiation.
Results: Compared with photons, protons caused significantly lower cell viability in chemoresistant cells and, in CSC-like cells, significantly lower clonogenic survival, invasiveness, and number of tumor spheres; less migration and CSC markers (coxsackievirus and adenovirus receptor, β-catenin, and side population cells); more apoptosis; and higher ROS level. CSC-like cells contained less than half the ROS levels of parental cancer cells or normal human bronchial epithelial cells.
Conclusions: CSC-like cells may be more sensitive to irradiation with protons than photons. The increased sensitivity could be caused by the greater ROS generated by protons. Because chemoresistant CSCs play an important role in tumor recurrence, protons may be more effective than photons in eliminating recurrent or persistent non–small-cell lung cancer.
Putative cancer stem cells (CSCs), which have enhanced DNA damage-repair mechanisms to overcome the DNA-damaging effects of radiograph radiation,1 are implicated in tumor cell resistance to radiotherapy or chemotherapy.2–7 Treatment strategies targeting CSCs may help to overcome this resistance in cancer patients.8 Charged particles with high linear-energy transfer, such as neutrons, may be capable of overcoming CSC DNA repair, but their severe effect on normal tissue renders treatment with these particles problematic for most radiotherapeutic applications. Like any charged particle, protons possess a radiation dose deposition characteristic called the Bragg peak.9 It is because of this property that proton therapy is able to spare normal tissues surrounding the tumor target to a much greater degree than can photon therapy. This characteristic may allow dose intensification for cancers such as non–small-cell lung cancer (NSCLC) and minimize dose-related toxicities to normal tissue.10–12
Because of its promising safety and efficacy profile, proton therapy is operational in 39 cancer treatment centers around the world, and many more centers are under construction or being planned. However, the biological efficacy of proton versus photon (radiograph) therapy is still poorly understood. The ability of protons to exert cytotoxic damage to cells has been considered to be 10% higher than that of photons such that the relative biological effectiveness (RBE) of protons is 1.1, regardless of the cell or tissue type.13,14 This RBE value is used routinely to adjust the clinical radiotherapy dose with protons as compared with photons. However, this adjustment is a gross oversimplification. Because of their charge and mass, protons produce locally higher ionization density regions along their tracks than photons do, producing a diffuse field of ionization through secondary electrons. Furthermore, neutrons produced by high-energy protons have a relatively high RBE. These factors may be responsible for observed differences in the sublethal damage:cell kill ratio between protons and photons and suggest that radiation-resistant cells may be more likely to be killed by protons than photons.15,16
We recently reported results from our phase II clinical trials of early-stage and locally advanced NSCLC treated with dose-escalated proton therapy.11 Our data showed that compared with photon therapy, irradiation with protons seems to reduce side effects and have high local control. The latter regimen might have had better clinical outcomes partially by having greater biologic effectiveness than what an RBE of 1.1 suggests. We hypothesize that the differences in the effectiveness were because of how CSC-like cells respond to proton therapy and photon therapy. We tested this hypothesis by using a previously established model of CSC-like cells from paclitaxel-resistant (chemotherapy resistant) NSCLC cell lines.2 We found that protons kill more CSC-like cells than photons do at the same radiation dose.
Human NSCLC cell lines A549 and H460 were obtained from the American Type Culture Collection and routinely maintained in Roswell Park Memorial Institute (RPMI)-1640 medium (Life Technologies, Grand Island, NY) supplemented with 10% fetal bovine serum, 10,000 U/ml of penicillin–streptomycin, and 2 mmol/liter of glutamine. Normal human bronchial epithelial (NHBE) cells were purchased from Clonetics Corporation (Walkersville, MD) and cultured as recommended by the manufacturer. The identities of these cell lines were validated by short tandem repeat profiling (performed by the Characterized Cell Line Core of The University of Texas MD Anderson Cancer Center) using the AmpFlSTR Identifiler polymerase chain reaction amplification kit (Applied Biosystems, Foster City, CA) according to the manufacturer's instructions. The short tandem repeat profiles for these cell lines matched their known American Type Culture Collection fingerprints.
We established two CR- and CSC-enriched NSCLC cell lines, H460/CR and A549/CR, by repeatedly treating parental H460 and A549 cells with paclitaxel to induce chemoresistance, as described previously.2 The cells were initially treated with 5 nM paclitaxel, and the surviving cells were then treated with increasing doses of up to 100 nM.
Stem cells can efflux Hoechst 33342 (Life Technologies) dye by means of verapamil-sensitive adenosine triphosphate (ATP)-binding cassette transporters. This classic stem cell characteristic is referred to as having a side population (SP). For each treatment-resistant cell line, SP cells (H460/CR/SP and A549/CR/SP cells) were obtained and sorted serially. We refer to these cells as CSC-like cells. Reanalysis of SP cells from the cultured SP cells demonstrated enrichment of the SP cells and production of non-SP (NSP) cells (H460/CR/NSP and A549/CR/NSP cells).2
Cell irradiation with proton beams was done at the Proton Therapy Center at the MD Anderson Cancer Center. Cells were irradiated at the center of the spread-out Bragg peak modulated to the depth of the cell layer. The irradiation system and biophysical characteristics of proton beams have been detailed elsewhere.11,12 For irradiation with photon beams, γ-rays from the cobalt-60 machine at MD Anderson Cancer Center were used with the same cobalt gray equivalent (CGE) on the same day.
The viability of parental H460 and A549 cell lines, treatment-resistant H460 and A549 cell lines, and NHBE cells was determined using the sulforhodamine B colorimetric assay 4 days after irradiation. Each experiment was done in quadruplicate and repeated at least twice.
For the clonogenic assay, parental H460 and A549 cell lines and treatment-resistant H460 and A549 cell lines (the latter with or without SP cells) were trypsinized, passed through a 40-μm sieve, and immediately irradiated at room temperature to generate a dose curve of 0, 2, 4, and 8 Gy. Corresponding control cells were sham irradiated. Colony-forming assays were begun immediately after irradiation by replating the cells into triplicate 100-mm culture dishes using the same method described previously.17,18 Colony formation was assessed 14 days after irradiation. To determine survival fractions, counts were normalized using the plating efficiency of the unirradiated corresponding control cells. Each experiment was done in triplicate and repeated at least twice.
Apoptosis of parental or treatment-resistant H460 cells (the latter with or without SP cells) was evaluated 48 hours after irradiation by flow cytometry with a terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate-biotin nick end-labeling (TUNEL) kit (Roche Applied Science, Indianapolis, IN) by dual color, as previously described.2,17,19 Three independent experiments were conducted.
To determine the invasiveness potential of parental and treatment-resistant H460/CR cells, we used the CytoSelect 24-well cell chemotaxis assay, flourometric format (Cell Biolabs, Inc., San Diego, CA) 48 hours after irradiation. The assay was performed exactly as described by the manufacturer. In brief, cells were starved of serum for 24 hours and subsequently seeded into the upper chamber onto a rehydrated basement membrane covering a Matrigel (BD Bioscineces, San Jose, CA) preparation with a diameter of 8 μm. Cells were allowed to invade toward 10% fetal calf serum for 24 hours. Cells that invaded to the bottom of the membrane were stained and quantified as described in the assay protocol. This assay was repeated three times.
We used flow cytometry with 2'-7'-dichlorofluorescein diacetate (H2DCF-DA) staining to determine the level of intracellular reactive oxygen species (ROS). Briefly, the day before the assay was performed, H460, H460/CR, H460/CR/SP, H460/CR/NSP, and NHBE cells were seeded at a density of 2 × 105 per well onto 6-well plates overnight. The cells were then irradiated with protons or photons at 0 or 4 Gy at different time points. H2DCF-DA was dissolved in dimethyl sulfoxide and diluted with prewarmed phosphate-buffered saline (PBS) to a final concentration of 5 µM. After treatment with radiation at different time points (from 6 hours to 9 days), the growth medium was replaced with PBS containing H2DCF-DA. After incubation for 40 minutes at 37°C, the cells were returned to a prewarmed growth medium and incubated at 37°C for 10 minutes. Cells were trypsinized and washed with prewarmed PBS once. The samples were then subjected to a flow cytometric assay using a Caliber fluorescence-activated cell sorter (BD Biosciences, San Jose, CA). These were performed at the Flow Cytometry and Cellular Imaging Core Facility at MD Anderson Cancer Center. All experiments were performed at least twice.
H460/CR/SP cells were suspended in 0.8% methylcellulose-based serum-free medium supplemented with 20 ng/ml epidermal growth factor, 20 ng/ml basic fibroblast growth factor, and 4 µg/ml insulin and plated at 2000 cells/ml in ultralow-attachment 24-well plates (Corning, Tewksbury, MA). The medium was replaced or supplemented with fresh growth factors twice a week. To assess the self-renewing potential of the cells, first-generation spheres were collected by gentle centrifugation, dissociated into single-cell suspensions, and filtered and cultured under the stem cell–selective conditions. The same procedures were repeated with the second- and third-generation spheres. Third-generation spheres were used in our experiments. A total of 1000 cells per ml was plated in ultralow-attachment 96-well plates (Corning, Tewksbury, MA) in 200 µl of growth medium cultured under the stem cell–selective conditions. The cells were then irradiated with protons or photons at 0 or 4 Gy. After 2 weeks of culture, tumor spheres were visualized with a phase-contrast microscope and counted in each well as described previously.2
Ninety-six hours (4 days) after irradiation of H460/CR/SP cells at 4 Gy, we used flow cytometry to determine coxsackievirus and adenovirus receptor (CAR) and β-catenin expression levels as well as the percentage of SP cells.2,17,19
Data are expressed as means and 95% confidence intervals, some are expressed as means ± SD. Analysis of variance and Student's t tests (two-tailed) were performed to test for significant differences. A difference was considered statistically significant when the p value was 0.05 or less.
To detect differences in the effects of the proton and photon modalities, we determined cell viability by sulforhodamine B colorimetric assay in NSCLC cell lines H460, H460/CR, A549, A549/CR and in NHBE cells on the fourth day after treatment with radiation doses up to 8 Gy at the same CGE (RBE = 1.1). We observed significantly weaker cell-killing effects of photons versus protons in the treatment-resistant cell lines (H460/CR and A549/CR) but not in the parental nonresistant cell lines or the NHBE cells (Fig. 1).
To determine whether proton therapy affects clonogenic survival in cancer cells differently than photon therapy does, we performed clonogenic formation assays with parental and treatment-resistant cell lines as well as with the putative stem cell fraction of the resistant cells identified as SP by Hoeschst dye exclusion. On the 14th day after irradiation with a dose of up to 8 Gy, colony formation of CSC-like cells (H460/CR/SP and A549/CR/SP cells) was significantly less with protons than photons (Fig. 2).
We also found that compared with photon radiation, clonogenic survival was significantly lower in treatment-resistant cells irradiated with protons at 4 Gy (p < 0.05 for both lines). However, no significant differences were seen for parental nonresistant cells or for resistant cells with NSPs. Taken together, these results indicate that protons better target CSC-like cells than photons do.
To investigate whether the enhanced cell killing by proton radiation occurred through an apoptotic mechanism, we quantified apoptotic cells using the TUNEL assay in H460, H460/CR, H460/CR/SP, and H460/CR/NSP cells at 48 hours after radiation. Both modalities induced marked increases in apoptosis in a dose-dependent manner in all four cell lines (Fig. 3A). However, protons induced significantly greater levels of apoptosis in H460/CR cells and in CSC-like cells (H460/CR/SP cells) than photons did.
To assess whether the differential effects of proton and photon irradiation on apoptosis in CSC-like cells we observed were reflected by cell motility, we examined the migration of malignant cells 48 hours after irradiation using the chemotaxis assay in H460, H460/CR, H460/CR/SP, H460/CR/NSP cells. In general, both proton and photon radiation suppressed migration in a dose-dependent manner, although we noticed a trend toward an increase in migration at lower doses (0.5 and 1 Gy) of photon irradiation (Fig. 3B). Compared with photons, protons at comparable doses significantly reduced migration in the CSC-like H460/CR/SP cells.
We next focused on changes in the invasive capability of cancer cells after irradiation using the Matrigel invasion assay the same four cell lines. The results mirrored our observations for cell migration (Fig. 3C). Thus, compared with photons, protons suppressed both the migration and invasiveness potential of the cancer cells even at lower radiation doses.
Radiation is cytotoxic because it induces double-stranded DNA breaks from ROS produced from secondary ionization of molecules.20 To determine whether the differential cytotoxic effects of protons and photons in CSC-like cells we observed were because of differences in ROS production, we measured the intracellular concentrations of pro-oxidants by using H2DCF-DA staining by flow cytometry. Baseline measurements showed lower ROS levels in parental H460 cells than in normal NHBE cells (Fig. 4A, left). We also found lower baseline ROS levels in CSC-like H460/CR/SP cells than in H460/CR or H460/CR/NSP cells (Fig. 4A, right).
Given these observations, we were interested to see whether there were differences in the production of ROS after proton or photon radiation. We measured ROS levels in H460, H460/CR, H460/CR/SP, and NHBE cell lines at 48 hours after irradiation with 0, 2, 4, 8 Gy (RBE = 1.1). Both modalities induced ROS levels increases in a dose-dependent manner in all four cell lines. Protons with 4 Gy induced significantly higher ROS levels than photons did in H460/CR cells (3.8-fold versus 2.6-fold) and H460/CR/SP cells (3.4-fold versus 2.1-fold), but not in H460 (3.6-fold versus 3.0-fold) and NHBE cells (1.2-fold versus 1.1-fold). We further measured ROS levels in H460 and H460/CR/SP cells for up to 9 days (216 hours) after irradiation 4 Gy. Protons induced significantly higher ROS levels than photons did in H460/CR/SP cells at almost all time points, but in the parental H460 cells at 7 days (168 hours) only (Fig. 4D). These results suggest that protons induce greater ROS levels in CSCs and thus have great cytotoxicity than photons do.
We tested the ability of proton therapy and photon therapy to affect the tumor sphere formation of CSC-like H460/CR/SP cells grown in suspension cultures using serum-free medium under stem cell–selective conditions.2 Both types of radiation significantly inhibited tumor sphere formation, but more so with proton radiation (17 ± 2 versus 32 ± 5; Fig. 5A, B).
Finally, we used flow cytometry to measure the expression levels of the CSC markers CAR, β-catenin, and SP 96 hours after irradiation at 4 CGE in H460/CR/SP cells. Only protons significantly reduced the expression of CAR (80.6% versus 92.1%) and β-catenin (20.3% versus 32.6%; Fig. 5C) as well as the percentage of SP cells (39.5% versus 50.1%; Fig. 5D) in CSC-like cells.
In this article, we investigated the biologic differences between proton beam therapy and photon beam therapy and determined whether protons (delivered with an RBE of 1.1) and photons have differential cytotoxic effects on CSC-enriched CSC-like cells as well. What we found was consistent with our previous data that protons kill more CSC-like cells than photons do at the same radiation dose. Regardless of the assay we used (for cell viability, clonogenic survival, apoptosis, cell migration or invasiveness, or tumor sphere formation), our current results indicate that protons have a greater biologic effect than what an RBE of 1.1 seems to indicate. Why CSC-like cells are more likely to be killed by protons is not entirely clear. Our data suggested that ROS generation was significantly higher in CSC-like cells with proton therapy than with photon therapy. Whether this is difference is related to the high ionization density of protons in the cells is also unclear.
ROS regulates a broad array of signal transduction pathways in various biological processes, including gene expression, cell growth, differentiation, and apoptosis. ROS caused by high glucose, angiotensin, tumor necrosis factor-α, irradiation, or other stressors enhances the apoptosis of various tumor cells. Effective management of ROS in normal tissue stem cells may contribute to their fitness and hence the life span of the organism.21,22 But what happens when the machinery for ROS management that is used by normal stem cells is hijacked by CSCs to maintain cellular fitness? The work of Phillips et al.23 showed that cancer-initiation cells are more resistant to radiation than are cells grown as monolayer cultures and that ROS levels are lower in cancer-initiation cells than in monolayer cultures after irradiation. The most recent findings in this area support and extend this concept. Diehn et al.1 demonstrated that human and mouse breast CSCs, similar to their normal tissue counterparts, maintain low levels of ROS that afford radioprotection, providing a possible explanation for tumor recurrence with photon therapy. Consistent with the idea of ROS being critical mediators of ionizing radiation–induced cell killing, CSCs were found to develop less DNA damage than nontumorigenic cells did and were more likely to be spared after photon irradiation. Lower ROS levels in CSCs are associated with increased expression of free radical scavenging systems.1 Our results are consistent with these reports. Further studies are needed to examine gene expression profiles of CSCs and non-CSCs in treatment-resistant NSCLC to determine whether the former have stronger antioxidant defense systems.
Pietro et al.24 demonstrated that compared with photon radiation, proton radiation significantly increased the intracellular level of ROS in CSCs and that it altered cell structures such as membranes, caused DNA double-stranded breaks, and significantly increased apoptosis and intracellular levels of ROS in the MCF7, PC3, and Ca301D cancer cell lines. Finnberg et al.15 further demonstrated that proton therapy triggers DNA damage and apoptosis in vivo more efficiently than photon therapy does and that the apoptotic responses varied greatly between proton and photon therapy in a tissue- and dose-dependent manner. Moreover, the work by Ogata et al.16 suggest that at lower doses, proton irradiation suppresses metastatic potential whereas photon irradiation promotes cell migration and invasive capabilities. The authors also provided preclinical evidence that proton therapy is superior to conventional photon therapy in preventing the metastasis of irradiated malignant tumor cells. Our own data on cell migration and invasion support these observations.
There are several limitations to our study. First, only CSC-like treatment-resistant cell lines generated from two parental cell lines (H460 and A549) were tested. In addition, only H460 cell line series were used for the test of apoptosis, cell migration/invasion, ROS levels, sphere formation, and CSC marker expression. It is possible that different cell lines may have varied sensitivities to proton beam because of different genetic backgrounds. Second, limited radiation doses and therapy designs were conducted because of limited machine time and biological safety issues in the patient treatment facility. We originally planned to use more cell lines and add in vivo study to validate our results. Thus, this report focuses on hypothesis generation; further studies are needed to validate these observations.
We have shown for the first time that treatment-resistant CSC-like cell lines are more sensitive to protons than photons at the same RBE. The greater effects of proton therapy on CSC-like cells could be because of the higher generation of ROS by protons than photons. Assuming that treatment-resistant CSCs have a role in the tumor recurrence, protons may be more effective than photons in eliminating recurrent or persistent NSCLC. Further laboratory studies, particularly in vivo experiments and clinical evaluation of ongoing and planned randomized trials at various disease sites, are needed to confirm this hypothesis.
Financial support was provided by Radiology Society of North America Research Scholar Award (to JYC), Career Development Award from The University of Texas Lung Cancer Specialized Programs of Research Excellence grant from the National Cancer Institute (to JYC), National Cancer Institute grants RO1 CA 092487 and RO1 CA 098582 (to BF), and National Institutes of Health Cancer Center Core Grant CA 16672. This research was supported in part by P01-CA021239 from the National Cancer Institute. MD Anderson Cancer Center is supported by the National Institutes of Health through grant CA16672.
Non–small-cell lung cancer; Cancer stem cells; Treatment resistance; Proton therapy; Photon therapy
Copyright © 2013 by the European Lung Cancer Conference and the International Association for the Study of Lung Cancer.
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What It Is
bINK'd is a line of temporary tattoo earrings for girls and boys. They are safe to wear, there is no pain like when you get your ears pierced, and the earring tattoos last up to five days. The tattoos are made using FDA-approved, kid-safe vegetable-based inks and adhesive. You apply them like you would any other temporary tattoo. Cut out the tattoo, remove the clear protective top sheet, and hold the tattoo image side down on your ear. Hold the wet applicator against the back of the tattoo and apply light pressure. After 15 seconds, slide the paper away, and your tattoo earring is now on your ear. To remove, use rubbing alcohol or baby oil. The bINK'd tattoos can also be used on nails, faces, dolls, and more.
The All-in-One Purse Set comes with everything kids need to apply the tattoos, including an applicator water pen, child-safe scissors, and two bINK'd design containers with 12 pairs of bINK'd earrings. The set is $15.95.
You can also purchase bINK'd design containers individually for $5.95. Each container comes with six pairs of images. There are a variety of images to choose from, including sports, flowers, animals, and holidays.
The applicator water pen can also be purchased separately for 75 cents.
Is It Fun?
If your child wants his or her ears pierced but is afraid of the pain or if your child isn't old enough to have pierced ears, then bINK'd temporary tattoo earrings are a good alternative. They're easy to put on and easy to take off, so kids can change their "earrings" every week. And kids will like that they can use the tattoos to decorate their nails, faces, and more.
Who It's For
bINK'd is for ages birth and up.
While they are safe to be used, parents will want to use their own discretion as to the best time to engage kids in this activity.
What To Be Aware Of
bINK'd can be purchased in specialty shops and Nordstrom stores and online at binkdkids.com, Amazon.com, and Buy.com.
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Lalaloopsy Tinies Jewelry Maker
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DohVinci Ornament Kit
from Hasbro
Inkoos Shopkins Color N' Fashion Messenger Bag
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Inkoos Shopkins Color N' Collect Strawberry Kiss
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from The Bridge Direct
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I think your plan to work with VDB first is a good one. The process is fairly simple and not very expensive. Later you might want to try kallitype which, when toned with palladium or platinum, is identical in appearance and tonal range to pt/pd.
Note, however, that for VDB you will need a very contrasty negative, one with a DR of log 2.0 or more. Your silver negatives will not give optimal quality with VDB. And unfortunately there are no simple ways to control contrast with VDB as there are with kallitype.
My pesonal recommendation is to go with the brush, either a Hake, or best of all, the brush that we folks on the alt-photo-process list call the Magic brush, a very fine synthetic brush made by Richeson.
A great paper, and also very inexpensive, that works well with VDB, kallitype and palladiuma and platinum, is Stonhenge Rising White. You can get if from Daniel Smith (out West) or from Steven Kinsella (in St. Louis) for less than 2$ per 22X30" sheet. In fact, closer to $1 a sheet. Another paper that works well and that is often available in local art stores is Strathmore 400 series drawing paper. It comes in pads in different sizes.


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(visit the link for the full news article)
An explosive device was detonated Friday morning by the back door of the U.S. Social Security Administration office, shaking downtown Casa Grande, but no one was injured.
Federal agents, including those of the FBI, rushed to the scene. The FBI would not confirm whether anyone was in custody, but the Casa Grande Dispatch learned that a Coolidge resident, Abdullatif A. Aldosary, 47, was being questioned.
Originally posted by Wrabbit2000
Thats funny... All weekend and not a peep?


text: Game Informer - Keiji Inafune isn't one to mince words. The former Capcom creative lead made headlines a few years back after proclaiming that Japanese game development was dead. He's since left the company to work on a number of new projects, including the upcoming Vita game Soul Sacrifice. We sat down with him and discussed the game, as well as his thoughts on heroism, sacrifice, and, oddly enough, Wonderbook.


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Does It Get Better???
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December 4 2011, 06:42 PM
The Dominion
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Location: Gamma Quadrant
Re: Does It Get Better???
I agree with TheGodBen. In retrospect I like the first two seasons the best because the Kazon arc keeps things going for me. Absolutely nothing was going on in the series in season 3 after that arc ended. And then in the later seasons they added the Borg and Species 8472, but neither crystallized into an actual arc, just a bunch of episodes.
A witty saying proves nothing. ~ Voltaire
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MILLERS COVE, TEXAS. Millers Cove is a residential community on Interstate Highway 30 just south of Winfield in Titus County. The community developed in the 1970s and incorporated in the early 1980s. In 1990 it reported a population of fifty-two. In 2000 the population was 120.
The following, adapted from the Chicago Manual of Style, 15th edition, is the preferred citation for this article.Christopher Long, "MILLERS COVE, TX," Handbook of Texas Online (http://www.tshaonline.org/handbook/online/articles/hnm81), accessed November 29, 2015. Uploaded on June 15, 2010. Published by the Texas State Historical Association.
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L.E. Wilson Max Cartridge Gage 9mm Luger
Product #: 888465 L.E. Wilson #: PMG-9MM
- Information
L.E. Wilson has been producing high quality precision reloading tools for over 80 years. The Max Cartridge gage gives reloaders the ability to check all critical maximum SAAMI cartridge dimensions of straight wall cartridges - mouth diameter, base diameter, rim thickness and diameter, case and overall length and bullet diameter.
Technical Information
If your cartridge will fit into the gage, it should fit in any firearm chambered to SAAMI specifications for this specific cartridge.
Not all firearm chambers or magazines are designed to SAAMI specifications.
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- Product ships from MidwayUSA, separate from any other products on your order due to its size. Products that are Shipped Alone incur separate "Per Order" and "Per Pound" shipping charges. Ships Alone: No
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Updated 04/17/2015
Tom Sawyer Island is a playground of hills, trees, rocks, and shrubs. Most attractions are on the main island, where your raft docks. The Mystery Mine is like a secret passageway to exploration. Children love Injun Joe's Cave, where there are lots of columns and crevices from which to jump out and startle siblings. As you explore the shoreline on the dirt paths, watch out for the barrel bridge—the whole contraption bounces at every step.
On the other island is Fort Langhorn, a log fortress from which you can fire air guns with great booms and cracks at the passing Liberty Belle riverboat. For people with disabilities: With its stairs, bridges, inclines, and narrow caves, this attraction isn't negotiable by those using a wheelchair. Get away from the crowds here. Watch toddlers closely, as it's easy to lose track of them.
Frontierland, Walt Disney World, Florida, 32830, United States
Sight Details:
Updated 04/17/2015
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December 1, 2015
A motorcycle driver was airlifted to a local hospital late Thursday night after a crash on FM 60 in Burleson County.
It happened just before 10:30PM in Snook.
DPS says a truck traveling east on FM 60 failed to yield the right of way and crashed into a motorcycle traveling west.
The motorcycle driver was in surgery early Friday at St. Joseph Health System in Bryan with several broken bones but officials tell us he is expected to survive.
The driver of the truck was arrested for driving with a suspended license.
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The following hotels have provided discounted rates for family members of Missouri State students. When calling to reserve a room, please remember to mention Missouri State to receive these discounted rates. All rates are subject to availability and do not include tax.
Within one mile of campus
Holiday Inn Express
1117 East St. Louis Street
Springfield, MO 65806
Phone: 417-862-0070
Rate: $115.00 per night (standard room)
Amenities: Breakfast, Internet access
University Plaza
333 S. John Q. Hammons Parkway
Springfield, MO 65806
Phone: 417-864-7333
Rate: $115.00 per night
Amenities: Breakfast, Internet access
Within five miles of campus
Best Western - Route 66 Rail Haven
203 S Glenstone Ave.
Springfield, MO 65802
Rate: 71.99 per night (2 double beds or 1 king)
Days Inn - Springfield South
621 W. Sunshine Street
Springfield, MO 6504
Phone: 417-862-0153
Rate: $74.99 per night (single); $76.99 per night (double)
Amenities: Breakfast, Internet access
Reservation code: MSU Family Weekend
Doubletree by Hilton Springfield
2431 North Glenstone
Springfield, Mo 65803
Rate: $115 per night (weekdays); $99 per night (weekends)
Based on availability
Hilton Garden Inn
4155 South Nature Center Way
Springfield, MO 65804
Rate: 15% off best available rate
Lamplighter Inn & Suites
2820 N. Glenstone
Springfield, MO 65803
Phone: 417-869-3900
Rate: $63.95 per night
LaQuinta Inn (Springfield East)
1610 E. Evergreen St.
Springfield, MO 65803
Phone: 417-520-8800
Rate: $72.99 per night (standard king or standard double)
Ramada Oasis (Convention Center)
2546 North Glenstone
Springfield, MO 65803
(888) 532-4338
$79 for standard room
$89 for poolside room
Ask for the Missouri State rate when making reservation
TownePlace Suites by Marriott Springfield
2009 South National
Springfield, MO 65807
Rate: $99 (studio king & sofa bed)
Within 10 miles of campus
Baymont Inn & Suites
3343 E Battlefield Rd.
Springfield, MO 65804
Rate: $59.49 per night (king); $63.74 per night (2 queens)
Reservation code: Missouri State Family Weekend
Days Inn
3260 East Montclair Street
Battlefield Road/Hwy 65
Springfield, MO 65804
Phone: 417-882-9484
Rate: *$69.95 per night (2 people, add $5 per night for each additional person)
Amenities: Breakfast, Internet access
LaQuinta Inn & Suites - Airport Plaza
2445 N Airport Plaza Ave.
Springfield, MO 65803
Rate: $84.99 (single); $89.99 (2 queens)


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I am a problem solver, a deep thinker and hacker with a knack to work around obstacles. I infect other people with my optimism. I am good at reading people and making team members outperform themselves. I code mostly in python and I like to focus on big data problems using noSql databases.Describe what you have done, what you are doing, and the kinds of things you are interested in.
I would say 2 things stand out in my mind. First is to have built a company as a single founder, Bueda, Inc. Despite not having achieved the traction I was hoping for, it went on to raise institutional funding and was an incredibly hard and rewarding experience. During this period we developed impressive technology, such as a highly optimized graph database to hold freebase in memory and achieve query latency in the microseconds. Despite the raw power of cutting edge technology, the most impressive aspect of it was building a motivated and amazing team running on a very low budget that produced impressive products. The second was to have completed a PhD in one of the top computer science schools in the world. A PhD from Carnegie Mellon is very hard but you get to hang out with some of the smartest people anywhere and you learn a lot.Describe the most impressive thing you've done.
I am looking for an opportunity to disrupt a big market and work with highly talented individuals to create amazing products that reach millions of people.Describe what you're looking for in a company.


text:
© 2005 by G. Edward Griffin -- Created 2005 May 12
Q: What role does science play in Freedom Force?
A: We have explained elsewhere that the cement that binds our members together is the ideology of freedom, not theology. On the other hand, there are those who have elevated science to the level of religious dogma and revere it with the same fervor as others worship God. This is especially common among collectivists who claim that everything they do is "scientific." Marx, Lenin, and Stalin called it scientific Socialism. Hitler exterminated Jews, Poles, and Gypsies in the name of science. In the field of physics and medicine, much of what was accepted as scientific truth a few decades ago is now discarded. One man's science is another man's myth. In terms of human values, science is indefinable.
Freedom Force does not operate in this arena. We do not wish to challenge anyone's beliefs regarding the nature of the universe, the origin and purpose of life, or the relevance of science. We welcome everyone, regardless of his or her beliefs. However, to enable people with diverse views in such matters to work harmoniously toward their common cause of freedom, it is necessary that we do not require conformity of thought and that we focus on those things we hold in common rather than our differences. It is for these reasons that science is not at the center of our movement.
Printed on 01 December 15 at 06:36
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The Top 10 In Action Sports
01Kenton Cool And The Legend Of Everest
02The Martyn Ashton Interview: Meet the Man Who Got Back on the Bike
03Legends Behind the Lens: The Dan Milner Interview
04We Asked Surf Star Coco Ho For Her Step-by-Step Guide to the Basics
05The Tony Hawk Interview: How Is The Birdman Still Flying High After All These Years?
06We Toured Britain's Action Sports Hotspots With The New Ford S-MAX
07The Legend Of El Dorado: One Man's Obsession With Finding A City Made Of Gold
08I Am Legend: How Audiences – Real Or GoPro'ed – Can Affect Your Mind And Performance
09Watch A Freerunning King Defy The Laws Of Gravity In This Urban Assault On London
10Living On The Blood and Urine of Dead Sea Turtles: The Shocking Story of A Sailor Stuck in Hell
KOVARIK RACING Session Mt Buller
A Mountain Biking video by thebaker - 11,856 views
With the first round of the Australian National Series taking place in Mt Buller it seems everyone was out there riding! Flat pedalled, bare handed Chris Kovarik is pinned and his better half Clair Buchar have speed and style in spades. Some may not be fans of slowmo but here its a damn good way to see how pro riders move on the bike and seeing Chris' body position in turn is something we can all learn from.


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queengu21's Gallery Comments
A very beautiful photo.
By: WhiteRose1
An unusual but very interesting photo.
By: NDODS
A superb catch.
By: Mollycat
Very nice capture that proves once again that simple things work best.
By: NDODS
V4 for me but they are so beautiful in all 4 variations.
By: Sylviwhalley
Happy Easter to you .Your photo is very colorful
By: DicksPics
Very good comp.
By: rios_uk
V 3 for me but to tell you the truth they are all beautiful.
By: Tish1
It just beams from one flower to another. Doesn' t it?
By: queengu21
I guess it must has a GPS at its disposal. Maybe it is the bionic kind?
By: queengu21
I really dig this rusty look.
By: Mollycat
Such a serene photo with a beautiful reflection un the water. Very nice catch.
By: NDODS
Thank you all for your useful comments which no doubt will help me to improve.
By: queengu21
A great photo.
By: TomCoetzee
All 3 are good but I like v2.
By: NDODS
If this is the blue one what is the red one? Seriously , a very good abstract.
By: Mollycat
Both are great but I prefer v1.
By: DicksPics
St George and the Dragon, Storkyrkan, Stockholm
Those were the days. A wonderful photo.
By: TT999
This is a beautiful set of photos
By: handlerstudio
I very much like the idea and the end result.
By: PranavMishra
A very good clear capture.
By: DicksPics
A very beautiful b&w photo.
By: paulknight
We had the same problem when we were there. These 2 photos are excellent.
By: WhiteRose1
Sod the washing up.....its Sunday.
I can fully sympathy with this feeling and to revolt against the
By: Mollycat