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Beyonce's New B'Day Bling
Beyonce's New B'Day Bling
by Celebrity
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No, she did not get a ring but she sure got a fancy new bling toy. Page Six reports that her man Jay-Z surprised B by taking her to the Time Warner garage yesterday and unveiling a 1959 Rolls-Royce convertible, worth, now get ready for this... $1 million! It goes without saying that Beyonce was speechless.
Lots more images of Beyonce promoting her B'Day album so
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Jay Z
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blOndiE7 9 years
I was dissappointed with what she wore and with her hair.. i wasnt feeling that too much at all..but oh well!
LaylaCams 9 years
She holds this type of love to hate type of thing in my heart. Crazy, I know. The girl is gorgeous tho.
keiraz 9 years
Lovely dress, gorgeous face, sexy body, wonderful talent..that lady's got it all!
Luna13 9 years
very stupid, if i had that much money, id spend half on it on a car and then give the rest to charity, whats the point of having so much money if u cant help people! 1 mill on a car is a waste
highsociety1 9 years
Either he really digs her, or he's got a guilty conscience! It's all relative. $1M to Jay-Z is the equivalent to about $100 to most people.
babybeluga 9 years
I like B, but everytime I've seen her recently (VMA's, TRL) she seems like she is always always posing.
pink_magnetism 9 years
$1 million dollar car??
Pokemyhontas 9 years
If she really liked the gift, then great. But lemme tell you....if it were ME, I'd have gotten in that million-dollar-friggin-old-hunk-of-metal and ran his dumb ass over and then straight to trade it in for a nice piece of ice for my RIGHT ring finger!
giana48 9 years
I am so bored of her...can't we just let her sink already? She drives? Maybe she can get a chaffeur to cart her ass around or something...
merryunbirthday 9 years
oh to be young, rich & unoriginal.... :-P
DulceSkye 9 years
I wouldn't spend my money like that if I were rich. I'd definitely be an Angelina type. My heart just bleeds for those less fortunate than me, and I'm nowhere near rich. If I had all that money, I'd be helping my fellow humans. I wouldn't be able to sleep at night, having a million dollar car in my garage knowing that there are people suffering, and earning five dollars a month. But that's just me. :) I'm sure Jay-Z and Beyonce do their fair share of charity work.
sphh18 9 years
Such a nice gift from Jayz, She worth it, He is so special with her, I bet they are going to have an amazing wedding...
colormesticky 9 years
Forget pictures of her promoting her album- I want to see pictures of the car! I think it's nuts to spend so much on a car, but hey. Jay Leno does it all the time and nobody gives him crap for it.
BlackBarbie21 9 years
jay z is entire too rich. he can throw it away on anything. they are not selfish and she is not overrated, just a lil misguided on the new album.
tharightgurl4u 9 years
She is overrated and Ive never seen pix of Beyonce DRIVING period so that was a waste of money!!
theotherhalfofme 9 years
Why would you pay one million for one car? Any awnsers?
nyaradzom2001 9 years
if my man had $1 million he better take me on an around the world trip including a visit to see my parents and my sister for a month and huge huge diamond rock and anything else my little heart desires but not a car from 1959 not even if it's rolls royce.
Shiloh-Jolie-Pitt 9 years
some ppl have just too much money.
DesignRchic 9 years
Honestly, if I had the money like they did, I'd be spending it too. I know that Beyonce does a lot of charity work and has donated money to many non-profit organizations, about Jay-Z, I haven't heard much of a selfless giving on his part. Yours Truly, DesignRchic
BlondeSugar 9 years
$1dollars for a car she will probably never drive
t0xxic 9 years
Speechless bc I bet deep inside she wanted a GD ring
Shiloh-Jolie-Pitt 9 years
good for her.
lovelygirl 9 years
They are so selfish !!!! Like she needs something that expensive !!
kitty805 9 years
i love her dress!
Moongal 9 years
all i can say, is lucky, lucky girl! she has it all


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Here is a look at the top cornerback prospects in this year's NFL draft as compiled by the Press-Gazette's Pete Dougherty. Information was gathered from conversations with scouts and other NFL personnel executives.
♦ 1. Louis Delmas, Western Michigan 5-11 3/8, 202 1/2: Four-year starter who had some minor injury problems but netted 12 career interceptions. A big hitter who last year had 111 tackles. Not as good in coverage but a solid all-around athlete with an attacking mentality. Ran the 40 in 4.56 seconds and had a 37-inch vertical jump at the combine. Hes a pretty fast, physical, tough, aggressive, get-after-you guy, one scout said. Just a relentless, throw-his-body-around-get-after-you player. No regard for his body at all. He shows up. He can improve in coverage in terms of recognition, and playing man coverage is a little bit of a liability. But as a striker and a guy that comes downhill and puts his hat on people in the run game, the guys pretty good.
♦ 2. Patrick Chung, Oregon 5-11 1/8, 212 2: Should be able to play both free and strong safety in a league where the distinction is fading because many NFL teams want their safeties to be interchangeable. Four-year starter who had nine career interceptions and ranged from 84 to 117 tackles each season. A sure tackler in the open field and also has solid ball skills. At the combine ran the 40 in 4.57 seconds, had a vertical jump of 34 inches and did 25 reps on the bench press. Good playmaker, has a good feel for the game, one scout said. Not a burner but hes a good player. Teams always wanted to know where he was because he had good tackling skills. I was never sure he was a fast guy, a couple times they got behind him and it didnt look like he could make up the ground.
♦ 3. Chip Vaughn, Wake Forest 6-1 3/8, 221 2/3: Has good size-speed ratio and is the kind of big man teams love at safety. Cover skills arent bad, but hes suspect playing the ball. Two-year starter who had only three interceptions in his career even though he also played regularly in nickel coverage his first two seasons. Ran the 40 in 4.51 seconds and had a 37-inch vertical at the combine. Real good athlete, good body, the guy looks the part without question, a scout said. OK tackler, for his size I thought hed be more physical. I thought he had very, very average ball skills, thought he struggled catching the ball and making plays on the ball. But hes smart. Physically hes what you want to work with. With the lack of safeties he could be a two, but I think hes a three.
♦ 4. William Moore, Missouri 6-1, 221 2/3: Comes from a hardscrabble background in Hayti, Mo., a small town in the southwest part of that state. Was a full-time starter the past two years. Made a name for himself with eight interceptions in 2007 but dropped to one last season after Missouri used him as more of an in-the-box safety. Has great size and good movement skills but lacks instincts. Ran the 40 in 4.62 seconds and had a 37-inch vertical jump. They played him more as a rover around the line of scrimmage instead of in the deep half (last year), one scout said. He struggles a little bit closing out on people in space, making tackles in space, despite his athletic ability. But physically the guy is 230 pounds or whatever he is, runs pretty good, can play around the line of scrimmage and can play deep. Hes a pretty good player.
♦ 5. Michael Hamlin, Clemson 6-2, 214 3/4: Started 36 games in four seasons and had 14 interceptions, including six last year. Has excellent size and is a good tackler but is not a hitter. Isnt fast but seems to have decent range. Smart and plays an understated game. Ran the 40 in 4.67 seconds and had a solid 37 ½-inch vertical jump. A good, solid player, one scout said. Not flashy, but watching him in the secondary the guy makes all their calls, gets people lined up. Theyve got some guys that are (not alert), and he lines them up. He doesnt seem like hes out of position very much. I like the kid, the way he plays and where he puts himself. Id like to see that kid on my team. Doesnt talk (trash), just plays.
Pete Dougherty, firstname.lastname@example.com

subset: commoncrawl


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We're hardwired to play games. We play them for fun. We play them in our social interactions. We play them at work. That last one is tricky. "Games" and "work" don't seem like a natural pairing. Their coupling in the workplace either implies goofing off (the fun variant) or office politics (the not-so-fun type).
The authors of Gamestorming, have a different perspective. They contend that an embrace and understanding of game mechanics can yield benefits in many work environments, particularly those where old hierarchical models are no longer applicable, like the creatively driven knowledge work of today's cutting edge industries.
Here is one of the 83 games featured in Gamestorming:
The ELEVATOR PITCH Game
OBJECTIVE OF PLAY: What has been a time-proven exercise in product development applies equally well in developing any new idea: writing the elevator pitch. When developing and communicating a vision for something, whether it's a new service, a company-wide initiative, or just a good idea that merits spreading, a group will benefit from going through the exercise of writing their elevator pitch.
Often this is the hardest thing to do in developing a new idea. An elevator pitch must be short enough to deliver in a fictional elevator ride but also contain a compelling description of the problem you're solving, who you'll solve it for, and one key benefit that distinguishes it from other ideas.
NUMBER OF PLAYERS: Can be done individually, or with a small working group
DURATION OF PLAY: Save at least 90 minutes for the entire exercise, and consider a short break after the initial idea generation is complete before prioritizing and shaping the pitch itself. Small working groups will have an easier time coming to a final pitch; in some cases it may be necessary to assign one person with follow-up accountability for the final wording after the large decisions have been made in the exercise.
HOW TO PLAY: Going through the exercise involves both a generating and a formative phase. To set up the generating phase, write these headers in sequence on flip charts:
To finish the setup, explain the elements and their connection to each other:
The Generating Phase
Once the elements are understood, participants brainstorm ideas on sticky notes that fit under each header. At first, they should generate freely, without discussion or analysis, any ideas that fit into any of the categories. Using the Post-Up technique, participants put their notes onto the flip charts and share their ideas.
Next, the group may discuss areas where they have the most trouble on their current pitch. Do we know enough about the competition to claim a unique differentiator? Do we agree on a target customer? Is our market category defined, or are we trying to define something new? Where do we need to focus?
Before stepping into the formative phase, the group may use dot voting, affinity mapping, or another method to prioritize and cull their ideas in each category.
The Formative Phase
Following a discussion and reflection on the possible elements of a pitch, the group then has the task of "trying out" some possibilities. This may be done by breaking into small groups, as pairs, or as individuals, depending on the size of the larger group. Each group is given the task of writing an elevator pitch, based on the ideas on the flip charts.
After a set amount of time (15 minutes may be sufficient), the groups reconvene and present their draft versions of the pitch. The group may choose to role-play as a target customer while listening to the pitch, and comment or ask questions of the presenters.
The exercise is complete when there is a strong direction among the group on what the pitch should and should not contain. One potential outcome is the crafting of distinct pitches for different target customers; you may direct the group to focus on this during the formative stage.
Don't aim for final wording with a large group. It's an achievement if you can get to that level of completion, but it's not critical and can be shaped after the exercise. What is important is that the group decides what is and is not a part of the pitch.
Role play is the fastest way to test a pitch. Assuming the role of a customer (or getting some real customers to participate in the exercise) will help filter out the jargon and empty terms that may interfere with a clear pitch. If the pitch is truly believable and compelling, participants should have no problem making it real with customers.
The elevator pitch, or elevator speech, is a traditional staple of the venture capital community, based on the idea that if you are pitching a business idea it should be simple enough to convey on a short elevator ride.
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Excellent book on group processes using game thinking. This is part of my short list of core books for consultants and facilitators.Published 2 months ago by Thomas Cox
Gamestorming was recommended to me and it went beyond my expectations. I used this book to guide a cross-functional product team through a two day design workshop. Read morePublished 2 months ago by Scott C. Branch
Dave does deserve a lot of credit for compiling the possible management activities into a book, which can act as a ready reckoner for some meeting. Read morePublished 3 months ago by Harish Nair
Quintessential reading material for anyone who what a problem to solve.Published 3 months ago by Greg Washington
Read the whole thing cover to cover and only got 5 teambuilding activities that I can use in a school environment.Published 3 months ago by reader63
Maybe it was just me but this book felt sooooo repetitive. It kept saying the same things over and over. I read the same thing at the end that I had read in the beginning. Read morePublished 4 months ago by Liz Trotter
Great book for getting thibgs done as a team. Stop having dull, unproductive meetings. Start collaborating, inventing, and problem solving in a thoughtful, creative, fun manner. Read morePublished 4 months ago by Martha Valenta
Gotta love the creative approach to both instruction and team-oriented problem solving. A classic that belongs in every professional consultant's bag of tricks.Published 4 months ago by Richard Randolph Jr.


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I am a tall, curvy girl who loves to rock some high heels, so height is a plus!!! Curvy does not mean obese ... I'm not a size 2 ... so, if hips and boobs scare you, you may want to move on to the next profile. ;) I am realistic about my expectations of myself and you. I take care of myself and so should you. Some of you apparently don't understand what that means. That is, put your best foot forward. No 10 year old pictures. No pictures with old girlfriends. We all know that a picture is worth a thousand words. What does yours say? Oh, and if you don't have a picture ... I won't respond.
I'm a relationship girl, not a one-night stand. At this point in my life, I'm looking for a partner, not a player. I am searching for someone who compliments my life, not controls it.
The good Lord made me hard to handle boys, so if you're up for the challenge .... I'm your girl!!! ;)


text:
Interview with Professor Andrew F. Huxley by Joanna Rose, science writer, 5 December 2001.
Professor Huxley talks about forgetfulness in science; about there being space only for one idea at a time (4:30); and that it is important to study the history of science in order to think more flexibly (9:59). He also talks about his famous family; his grand father T.H. Huxley, a friend of Darwin ('Darwin's bulldog'); and his half brother, Aldous Huxley, author of 'Brave New World' (12:44).
Try to save some patients and learn about human blood types!
Facts on the Nobel Prize in Physiology or Medicine
All you want to know about the Medicine Prize!
The Nobel Prize in Physiology or Medicine
Read more about the Medicine Prize during the past century


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The Avenue Talks
in Music
We got Milli2Commaz coming to sit down with Te Avenue Talks to get an exclusive interview
Fifth Avenue Jeweler Marketing and Advertising Tools
in Entrepreneur
Discussion of marketing and advertising tools for all Fifth Avenue Jewelers. We will discuss how I will be promoting the team and also educating those who would like to become Jewelers. This segment will also be placed on You Tube by Desiree CEO of Rich and Rich Entrepreneurs and Rich and Rich Home Opportunities. Fifth Avenue Jeweler allows you to sign up to be on the team and will discuss business cards, flyers, offline, and online promotion. We are also on Facebook.
Official Dopple Avenue Hurt Season 2 Trailer
in Comedy
The official trailer for Dopple Avenue Hurt Season 2, coming in August!
Please rate and review us on iTunes and if you would like to donate to the production of this show, please visit our Patreon page and become a part of what keeps this show in production.
Episode 157: Your regularly scheduled programming
in Baseball
Normally by now on Amazin' Avenue Audio, we would have done a season review, an offseason preview, and some Rule 5 talk, but as you may have heard on podcasts like this one, the Mets spent all of October in the playoffs. So we have some catching up to do. First Jeffrey and Kate review the 2015 season one last time and discuss the Terry Collins extension. Next, Jeffrey and Brian look at some early roster moves and the Mets crop of free agents.Then, Jeffrey and Greg discuss Rule 5 protections and further 40-man roster machinations. Oh there's more, Jeffrey and Lukas preview the Mets offseason and discuss the *sigh* shortstop situation. Finally, Jeffrey and Milo answer your e-mails until Jeffrey finally has to cry 'uncle.'
Episode 159: Our Annual AAA AAOPs
in Baseball
It's time for your hosts Amazin' Avenue Audio Offseason Plans, but Chris McShane can't be bothered to defend his 2014 title (which he won by cheating). He claims he is sick or something, leaving Jeffrey and Greg to debate the merits of Hansel Robles, 8th inning guy versus Dexter Fowler, leadoff hitter. Next, we answer your e-mails on Jeremy Hefner, Marcell Ozuna, and once and future podcast legends. Finally, we end the show with Greg dropping some Irish soccer (?!) knowledge.
Episode 160: No news never stops the pod
in Baseball
In Episode 160, Jeffrey and Lukhas discuss all the goings-on in Metsland, which include...well...uh...the Mets are interested in Ben Zobrist? Jordan Zimmermann signed with a team in the AL Central? People on twitter want to trade Lucas Duda? Yeah, it is the miserable dregs of the offseason where we have nothing to talk about and still somehow fill 60 minutes. We also answer your e-mails about Daniel Murphy, JA Happ, Matt Harvey, Daniel Murphy, baseball history and Daniel Murphy. Well, at least some things never change.
Episode 158: AAA_email.exe
in Baseball
You won't stop e-mailing the show, so Jeffrey and Lukas break the emergency weekend podcast seal to clean out the inbox. And since there is a bit of Mets news to cover we kick things off with a discussion of Daniel Murphy's Qualifying Offer and the Mets "attempts" to trade for Andrelton Simmons. Then it is onto your e-mails about Adam Eaton, Denard Span, trading Lucas Duda, spending lots of money, the Mets shortstop situation, and (sigh) Jose Reyes. Finally, we wrap things up with a belated IFK Goteborg update.
Episode 149: NLCS Game 2: Thorrrrrrrrrrrr dot mpeg
in Baseball
In episode 149 of Amazin' Avenue Audio, Jeffrey and Steve recap the Mets Game Two win over the Cubs in the NLCS. We've run out of things to say about Daniel Murphy, and we can't say it any better than Pedro when it comes to Noah Syndergaard, so we just end up exchanging recipe ideas by the end of the show. Though there is some (more) real talk about our emotional state as it relates to the 2015 Mets for those of you that (rightfully) demand actual Mets content in your Mets podcasts.
Episode 152: World Series (?!) Preview
in Baseball
In the first ever Amazin' Avenue Audio World Series preview Jeffrey and Greg are confused and terrified. This was true before every other Mets playoff series though, so a good omen perhaps? We discuss the Mets playoff rotation, how confident we are in the Mets bullpen, and who on the Royals scares us the most. Next, Andy McCullough, who you may remember from appearances on such podcasts as this one, joins the show to delve further in depth on the Mets World Series opponent. Then, David Roth is back to talk about Pat Misch, Alay Soler, and other non-World-Series playing Mets we have known. Finally we wrap things up with your emails. It's just like a regular podcast, except the Mets are about to play in the World Series ohgodohgodohgodohgodohgod.
Episode 151: NLCS Game 4: So this happened
in Baseball
In Episode 151 of Amazin' Avenue AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
(so that happened, Jeffrey, Greg, and Steve try to talk about it coherently. They mostly succeed we think. On the agenda: The 2015 National League Champion New York Mets are your 2015 National League Champions. They don't have great merchandise, but they do have Daniel Murphy, who is hotter than the rapidly expanding universe after the Big Bang which also resembles the speed and trajectory of all his crazy dingers.)
Audrey Lusk is my Guest Author on November 16th
in Books
I am delighted beyond words to have Audrey Lusk as my guest author November 16th! This wildly talented woman is not only a fabulous audio book narrator, but she's also an author! Come listen as she talks about audio book creation, and reads an excerpt from her erotic sci-fi shortie, Forking Around.
* * *
A sassy, dimension-hopping (sort of) woman finds an invisible man (sort of), and decides to "see" what might come of a relationship that isn't quite definable.
About the Author:
Audrey Lusk has led a life that reads like fiction. As a voice actor, Audrey's performances of many erotic stories grace the Audible "shelves". And yet, for someone who spent time in modern burlesque, made and sold her own Goth clothing line, and ran professional murder mystery parties, she's a surprisingly evasive and retiring individual - and insists that these things found her, not the other way around.
Now that she's finally found a way to make writing and recording audiobooks her main focus, she plans to stick to it, averring triumphantly "I don't have to get dressed."
Episode 148: NLCS Game 1: The Dark Knight: Master Ace
in Baseball
The Mets won Game 1 of the NLCS behind a sterling performance by Matt Harvey, and Jeffrey and Steve are hear to talk about it in Episode 148 of Amazin' Avenue Audio. Not at the bar where they were watching the game (Jeffrey's phone died), but several hours later when we were all very sleepy. "Let's do it in ten minutes" was the off-air directive, so of course enjoy thirty minutes of discussion on Harvey shoving, Familia freezing, Murph murphing, Beltran playoff stat reading, and general incoherent babbling. Up the Night Owls!
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Cerebral ischemia involves a series of reactions which ultimately influence the final volume of a brain infarction. We hypothesize that polymorphisms in genes encoding proteins involved in these reactions could act as modifiers of the cerebral response to ischemia and impact the resultant stroke volume. The final volume of a cerebral infarct is important as it correlates with the morbidity and mortality associated with non-lacunar ischemic strokes.
The proteins encoded by the methylenetetrahydrofolate reductase (MTHFR) and glutathione S-transferase omega-1 (GSTO-1) genes are, through oxidative mechanisms, key participants in the cerebral response to ischemia. On the basis of these biological activities, they were selected as candidate genes for further investigation. We analyzed the C677T polymorphism in the MTHFR gene and the C419A polymorphism in the GSTO-1 gene in 128 patients with non-lacunar ischemic strokes.
We found no significant association of either the MTHFR (p = 0.72) or GSTO-1 (p = 0.58) polymorphisms with cerebral infarct volume.
Our study shows no major gene effect of either the MTHFR or GSTO-1 genes as a modifier of ischemic stroke volume. However, given the relatively small sample size, a minor gene effect is not excluded by this investigation.
In the United States, after cardiovascular disease and cancer, stroke is the third leading cause of death. However, it is the leading cause of morbidity resulting in about 4 million stroke survivors each year [1]. Although there are epidemiological differences in various ethnic groups, the majority of these strokes are ischemic rather than hemorrhagic in nature. There are a number of well established risk factors for the development of ischemic stroke including diabetes mellitus, atrial fibrillation, hypertension and age [2]. Once an ischemic stroke occurs, in spite of intense research efforts, little progress has been made in the discovery or development of effective neuroprotective agents.
While there are recent research efforts investigating susceptibility genes for ischemic stroke, there are few investigations of the genetics of the cerebral response to ischemia [3,4]. Studies of induced strokes in transgenic animals indicate that manipulation of certain genes can influence the resultant volume [5,6]. We hypothesize that there is variability in the cerebral response to ischemia that is mediated by polymorphisms in genes encoding proteins which participate in this response. Polymorphisms in these genes could enhance or diminish endogenous neuroprotective mechanisms and ultimately impact the volume of an ischemic stroke. This has clinical significance because, in general, the volume of a stroke correlates with severity and the resultant degree of disability of the patient [7,8].
It has been established that cerebral ischemic injury results in a core of necrotic tissue surrounded by a penumbra of tissue in which neurons are functionally inactive but still potentially viable [9]. The development of this ischemic penumbra is limited in time by a cascade of reactions in response to the initial ischemia followed by subsequent reperfusion. Reperfusion occurring shortly after ischemia reduces infarct volume, but at a later period may exacerbate ischemic injury [10]. It has been suggested that reperfusion increases reactive oxygen species (ROS) production which can have further deleterious consequences. Neuronal cell exposure to these ROS, which include nitric oxide, superoxide ions and hydroxyl radicals, can result in oxidative deoxyribonucleic acid (DNA) damage [11-14].
Methylenetetrahydrofolate reductase (MTHFR) and Glutathione S-transferase omega-1(GSTO-1) are two genes that are key participants in the metabolic pathways regulating oxidative stress in the brain (Fig 1). The C677T polymorphism (NCBI SNP cluster ID rs# 1801133) in MTHFR gene results in an alanine-to-valine (A222V) substitution which in turn causes a reduction in enzyme activity and subsequent elevation of plasma homocysteine [15,16]. Hyperhomocysteinemia (HHcy) has been reported as an independent risk factor for stroke but may also influence ischemic stroke volume. A study of the cerebral volume and induced stroke following middle cerebral artery occlusion in mice showed that HHcy was associated with increased oxidative damage and larger ischemic lesion [17-19]. The homocysteine (Hcy) dependent trans-sulfuration pathway is responsible for maintenance of the intracellular glutathione pool and regulation of this pathway under oxidative stress (Fig 1). GSTO-1 is member of Phase II enzymes that catalyze glutathione-dependent antioxidant pathways (Fig 1). Furthermore GSTO-1 modulates rynodyne receptors thereby protecting cells against Ca2+ induced apoptosis and inhibition of the posttranslational processing of pro-inflammatory cytokine interleukin-1β [20,21]. The C419A (NCBI SNP cluster ID, rs 4925) polymorphism in GSTO-1 gene has been reported to be involved in stroke [22]. The C419A polymorphism results in amino acid alteration alanine-to-aspartate; this change in the protein sequence reduces enzyme activity and therefore could influence tissue susceptibility to oxidative stress [23].
Figure 1. The metabolic pathways regulating oxidative stress. Abbreviations: MTHFR- Methylenetetrahydrofolate reductase, THF- tetrahydro folate, Hcy- Homocysteine, SAM- S-Adenosyl methionine, eNOS-endothelial nitric oxide synthase, iNOS-inducible nitric oxide synthase, ADMA- asymmetric dimethylarginine, NO- nitric oxide, O2- – superoxide radical, ONOO- peroxinitrite, H2O2-hydrogen peroxide, NADPH – nicotinamide adenine dinucleotide phosphate, GSTO-1- Glutathione S-transferase omega-1, GSSG -glutathione disulfide, ROOH- reduced hydroperoxides, ROH- alcohol, H2O- water.
Given the key roles of the products of these two genes in the cerebral response to ischemia, they are candidate genes which warrant further investigation. We hypothesized that the MTHFR C677T and GSTO-1 C419A polymorphisms may modify the response of the brain to cerebral ischemia and ultimately impact the final stroke volume. To test our hypothesis we studied the relationship of these polymorphisms with infarct volume measured in patients who have suffered an ischemic stroke.
Human subjects
We studied 128 patients admitted to the stroke unit at John F. Kennedy Medical Center, Edison, New Jersey with non-lacunar ischemic infarcts. The strokes were categorized according to the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) [24]. Among these patients, applying the TOAST classification, the etiology of the non-lacunar ischemic strokes included 37 large artery atherothrombosis, 37 cardioembolic, 49 unknown and 5 others. In the majority of patients (79%), diffusion-weighted magnetic resonance imaging scans were available for review; alternatively, cerebral computed tomography scans (21%) were used to measure stroke volume. The stroke volume was obtained by averaging the calculated values from direct measurements of the cerebral images by two examiners as previously described [25]. Informed consents were obtained from the patients or their proxies and study was conducted according to protocols and methods approved by the local Institutional Review Board.
Genomic DNA was isolated from blood samples (Puregene Systems, Gentra). The MTHFR polymorphisms were genotyped as previously described [15]. Briefly, the primer pairs used were F: 5'-TGAAGGAGAAGGTGTCTGCGGGA-3' and R: 5'-AGGACGGTGCGGTGAGAGTG-3'. The C677T polymorphism creates a restriction site for Hinf I, so the digestion of the polymerase chain reaction (PCR) products of the mutant allele generates two fragments (175 and 23 bp). The digested products were resolved by gel electrophoresis (6% polyacrylamide gel) and the allele frequency was obtained by direct gene counting. The genotypes obtained with this method were confirmed by direct sequencing.
The GSTO-1 polymorphism was detected after PCR amplication using following primer pairs F: 5'-TGTCTAGGTGCCATCCTTGGT-3' and R: 5'-AAGTGACTTGGAAAGTGGGAA-3'. PCR was carried out in a final volume of 50 μl with 40 ng of DNA, 600 μM dNTP and 2.5 U Amplitaq gold polymerase. Thermal cycling consisted of initial activation (95°C for 7 min) followed by 35 cycles of denaturation (95°C, 30 s), annealing (56°C, 30 s), and extension (72°C, 30 s) and a final extention at 72°C for 7 min. PCR products were digested with restriction enzyme Cac8I at 37°C overnight and the digested products were resolved by gel electrophoresis (6% polyacrylamide gel). The digestion generates two fragments (147 bp and 60 bp) corresponding to C (restriction site present) and a single 207 bp product corresponding to the A allele (restriction site absent). The allele frequency was obtained by direct gene counting. The genotypes obtained with this method were confirmed by direct sequencing.
The clinical and demographic data of the study group is presented in table 1. The genotypes of the MTHFR C677T and GSTO-1 C419A polymorphisms are presented in table 2. The observed numbers of each genotype was compared with those expected under Hardy-Weinberg equilibrium (HWE) by using a web-based program http://ihg.gsf.de/cgi-bin/hw/hwa1.pl webcite. No significant deviation from HWE was observed. The mean Hcy levels corresponding to each genotype is presented in the table 3. Although the mean Hcy level is higher in the group with MTHFR TT genotype, it is not statistically significant. To detect the effect of the MTHFR C677T and GSTO-1 C419A polymorphisms on stroke volume ANOVA and generalized linear model analysis was done. The mean stroke volume was 71.37 cm3 (SD 90.1 cm3). There was no significant influence of the MTHFR (p = 0.72) or GSTO-1 (p = 0.58) polymorphisms on the stroke volume. The analysis was also performed for Caucasian population alone which represented 67.2% of the study population. However no significant effect of either MTHFR (p = 0.41) or GSTO-1 (p = 0.83) polymorphisms on the size of stroke was detected.
Our analysis did not show a major gene effect of either the MTHFR C677T polymorphism or GSTO-1 C419A polymorphism on the volume of the ischemic infarct. However, minor genetic effects are not excluded by this study. It is possible that such minor gene effects may be additive and particular combinations of polymorphisms from different genes may confer neuroprotection. These minor gene effects could be detected by studying a much larger sample size.
In addition to investigating genes involved in the response of the brain following ischemia, there are other variables that could confound the analysis. For example, due to our relatively small sample size we did not separate and analyze the volumes of strokes occurring in a particular vascular distribution. To enhance the detection of minor gene effects, future studies could focus only upon middle cerebral artery stroke. In this study, again due to small sample size, we did not limit our analysis to those strokes of a particular etiology but rather focused upon the entire group. There may to be biological/genetic differences in the cerebral response to ischemia in cardioembolic stroke compared with large artery atherosclerosis.
In spite of the negative results, our study demonstrates the feasibility of studying the potential role of genes which participate in the cerebral response to ischemia and ultimately influence stroke volume. Many of the difficulties of any such investigation can be overcome by studying a larger sample size of patients. These studies could provide insight into endogenous neuroprotective mechanisms and facilitate the development of more effective therapies.
MTHFR: Methylenetetrahydrofolate reductase; GSTO-1: Glutathione S-transferase omega-1; ROS: Reactive oxygen species; DNA: Deoxyribonucleic acid; HHcy: Hyperhomocysteinemia; Hcy: Homocysteine; TOAST: Trial of ORG 10172 in Acute Stroke Treatment; PCR: Polymerase chain reaction; HWE: Hardy-Weinberg equilibrium.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
LRP carried out the molecular genetic study and analysis and drafted the manuscript. AVD assisted with the molecular genetic study. ML performed the statistical analysis. SS participated in the design and finalizing the manuscript. RG participated in the design, coordination of the study and finalized the manuscript. The manuscript is read and approved by all the authors.
This study was funded by intramural funds from the New Jersey Neuroscience Institute and the Neurogenetics Foundation. We are grateful to all the Hematology laboratory personnel at JFK Medical Center, Edison, NJ for their help in collection of blood samples for this study. We also thank Dr. G.K. Dhaliwal for criticism and comments regarding this manuscript.
Rosamond W, Flagel K, Friday G, Furie K, Go A, Greenlund K, Haase N, Ho M, Howard V, Kissela B, Kittner S, Lloyd-Jones D, McDermott M, Meigs J, Moy C, Nichol G, O'Donnell CJ, Roger V, Rumsfeld J, Sorlie P, Steinburger J, Thom T, Wasserthiel-Smoller S, Hong Y, American Heart Association Statistics Committee and Stroke Statistics Subcommittee: Heart disease and stroke statistics–2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee.
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Pre-publication history
The pre-publication history for this paper can be accessed here:


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Farmers are no different from any buyer – they want to know what they're buying, how much it costs and its expected performance. But in the brave new world of agricultural seeds, where multiple traits and technology are stacked like Microsoft's operating system, it's becoming more and more difficult for farmers to separate out what is really needed and discover how much each piece is costing them. In the case of neonicotinoid (neonic) seed coatings used as a pesticide, both the effectiveness and costs are somewhat of a mystery, according to a new paper published by IATP today.
As farm income is expected to drop more than 30 percent from last year, farmers are carefully examining all input costs to see where they can save. With their financial cost and actual effectiveness unclear, neonic seed coatings may be one of those places to cut costs. But the real cost of neonics likely goes well beyond the input price. A growing body of science directly implicates neonicotinoid (neonic) pesticides as a contributor to the significant decline of bees and other pollinators. Neonics are applied in multiple ways in agriculture and horticulture but are most prevalent as a seed coating material for commodity crops like corn and soybeans. Based on convincing and mounting evidence, beekeepers, scientists and other individuals concerned about pollinators are working together to spur regulatory action and shifts in the marketplace to reduce the use of neonics.
In May 2015, the White House issued an interagency National Strategy to Promote the Health of Honey Bees and other Pollinators. The strategy focuses on efforts to restore honey bee loss, increase monarch butterfly populations and restore pollinator habitats. But the White House plan virtually ignores the on-the-ground farm economics that directly contribute to rising neonic use in seed coatings – specifically the role of a few large companies that have a stranglehold on the seed market. This concentrated market power in the seed industry has allowed a few multi-billion dollar companies like Bayer, Syngenta and Monsanto to significantly limit U.S. farmers' choices around seed coating.
In most cases the seed is coated with neonics whether wanted or not and our paper found that this lack of choice has made it difficult for farmers and their advisors to assess the actual value of these pesticides in crop production, or to understand their true financial and environmental costs. Most farmers understand the value of pollinators to plant growth and the food system and would not intentionally harm them. However, without credible information on the risks or the freedom to choose their seed coating, farmers are left with little choice but to accept what their seed company delivers.
The good news is that there are independent seed companies and dealers able today to provide farmers with information and choice around seed coatings. Representing a small segment of a highly consolidated industry, independent seed producers and dealers are able and willing to respond to market changes and farmer preferences associated with not only neonics, but also other areas of market interest, such as non-genetically modified organisms (GMOs), certified organic, cover and specialty crops. But a farmer's ability to choose what kind of seed coatings they want as part of their crop management system should be the rule, not the exception, in the seed market.
One of the most basic and necessary aspects of a free market is available and accurate information about products and their efficacy, cost and benefits. It should go without saying, then, that in a competitive marketplace, farmers should receive accurate, up-to-date information from researchers and other farmers at field days about the costs and benefits of neonics and other seed coatings related to both crop production and the environment, including pollinators. Yet, this isn't happening with neonics or other seed coating ingredients today. We need credible, farmer-led field trials that compare different seed coatings and traits, and that information should be shared with other farmers. And those findings should be compared with the effectiveness and costs of other pest control approaches, such as integrated pest management (IPM), that have proven benefits and economic returns. Only with complete information and choice – about neonics and other crop management tools – can farmers make smart choices that allow them to produce crops and take care of pollinators and the environment.
You can read the full paper: Unknown Benefits, Hidden Costs: Neonicotinoid seed coatings, crop yields and pollinators.
- See more at: http://www.iatp.org/blog/201508/pollinators-and-the-rigged-neonic-seed-m...
In the case of neonicotinoid (neonic) seed coatings used as a pesticide, both the effectiveness and costs are somewhat of a mystery, according to a new paper published by IATP today.
Here at PAN, we focused on fighting for state policies to better protect honey bees and other pollinators from pesticides. How did things shake out on our issues? Well, there was some good, some hopeful and some ugly.
1- Know the issue
With so much conflicting information available online, it's important to
EPA's new rule has made headlines. After years of pressure from PAN and our partners for federal decisionmakers to take the bee crisis seriously, it's good to see EPA acknowledge the pesticide problem. But EPA's proposed new rule is remarkably short on meaningful action.
As part of EPA's proposed new rule, the agency
While the plan sets an ambitious goal for reining in honey bee losses, and calls for state plans to increase habitat for pollinators, it fails to directly address the impact of neonicotinoids and other insecticides, despite crystal clear science that these chemicals are impacting pollinators.


text:
- 334Promote
iPhone Cases
Stack IIIby Georgiana Paraschiv
Protect your iPhone with a one-piece, impact resistant, flexible plastic hard case featuring an extremely slim profile. Simply snap the case onto your iPhone for solid protection and direct access to all device features.
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Level :PhD | Stream :Sciences | Subject :Relativistic Cosmological Models
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Robert K Conyne; F Robert Wilson; University of Cincinnati.; Microtraining Associates.
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|07-01-2011, 16:59
Registered User
The Bible is not always literal translation of history, the bible openly uses parables and metaphors to explain concepts, have you not read the book of revelations where the prophet does not understand the signs and symbols, an angel has to decrypt the metaphors. Genesis is allegorical.
|08-01-2011, 11:21
Registered User
Link to DNA forums piece
Would you have time to give the link to the piece you qouted on page 13?
"Here is something from the DNA Forums website. The author no longer posts there but it seems he was well respected for his archaeological knowledge.
It's not surprising that you are having trouble with the Iberian idea. Its nonsense. It's been rejected by archaeologists, historians, classicists, Celtic studies experts, linguists etc for several decades. It is essentially based on nothing but the Irish invasion legends. The latter were written by monks writing in a classical tradition whereby a history or ethnology is put together by trying to connect tribes and places with similar names and linking them. Often when modern linguists look at them the etymology is completely nonsensical. In the case of the Milesian myth the word linking was Hibernia=Iberia, Scoti=Scythia etc etc. The legend is full of people given names to represent ancient names for the Irish - Goidel Glass (Goidel-Gael), an Egyptian princess 'Scota' or similar.
|08-01-2011, 15:21
Registered User
|08-01-2011, 15:41
Last edited by fontanalis; 08-01-2011 at 15:44.
|09-01-2011, 09:33
Registered User
thanks very much for that.
I've only been able to give this thread a skim; but I think it's very interesting to analyse this issue (prehistorically and historically.)
Maybe another title for this thread could be 'The first "Irish" people'?.
Zoologists warn against anthropomorphising non-human animal life.
Just as historians warn against 'Nationalising' the history of our our little geographical territory?
|Thanks from:
|24-01-2011, 11:38
Join Date: May 2002
Location: D�n Laoire, Bl�th Cliath, �ire
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The R1b found in Cameroon is a different branch of R1b, there are multiple sub-branches as can be seen on the Haplogroup Tree for R.
The Western European R1b is mostly made up of the P312 clade (R1b1b2a1a2). African R1b is marked by the V88 clade (R1b1a)
This points that both shared a comman male ancestor at a very early stage. V88 isn't found in Europe apart from in recent immigrants and is tied with the expansion of the Chadic languages in Africa.
Within P312 there are several distinct subclades. The most common in Ireland is L21 (R1b1b2a1a2f) which is found from Ireland in the west to Austria in the east (very common in France). It's been postulated that the expansion of L21 is tied with that of Celtic languages. In Ireland there are a number of sub-clades of L21 that are tied to specific Irish septs/tribes.
For example M222 (R1b1b2a1a2f2) is tied to the Uí Neill and the Uí Briúin and the Uí Fiachra which are both branches of the ancient Connachta (supposedly descended from the half brothers Niall,Brion and Fiachra).
L226 (R1b1b2a1a2f4) appears to be the signature of the Dál gCais, it's reported in men who bear Dál gCais surnames including "The O'Brien" (Baron Inchiquin)
I myself am just plain old L21* I haven't tested positive for any of the let discovered sub-clades under L21.
Germanic R1b is mostly in another P312 clade. This is S28/U152 (R1b1b2a1a2d) which has a very high incidence in the Netherlands. The other major haplogroup among the Germanics is I2b which is interesting as linguists often consider that Germanic languages has been heavily influenced by a non Indo-European language.
In Ireland 90% of men are R1b most of remaining 10% belong to haplogroup I specificially I1 which appears to be that of the pre-celtic speaking male population. Irish men who are I2b are showing potential Germanic ancestory (be that viking/Norman/English/Palatine German)
Some have postulated that the Centum/Satem spilt in Indo-European languages are connected with difference between R1a and R1b. For example most Satem language populations are high in R1a (slavic/baltic/Indic/Iranic) whereas R1b is high in Centum languages (Celtic/Germanic/Italic)
Last edited by dubhthach; 24-01-2011 at 11:41.
|24-01-2011, 14:31
R1b is oh my god like so 2005; E or J would be good.
|24-01-2011, 15:02
Join Date: May 2002
Location: D�n Laoire, Bl�th Cliath, �ire
Posts: 2,760
All of these clusters as far as I know are L21 here's a list that I know of:
Someone who is in say the Uí Neill cluster will have STR markings close to this: M5UKQ
If they then did SNP testing would probably show them as M222+, 23andme doesn't test for STR's but for SNP's so depending on list of SNP's on their chip you might be able to get quite exact data on your y-chromosome.
I've tested with Familytreedna, have results of over 95 STR's but I don't have any matches in their database with anyone within the last 6 generations, I also don't belong to any clusters. As part of my testing I've done deep clade SNP testing. Which has shown I'm just L21+
There's a very interesting project been run called "The Dodecad project" where they take your 23andme raw data and tell you the exact break down of your autosomal DNA (population admixture). For example the Irish members (8) of project break down on average as:
Northern European: 64.9%
Southern European: 26.7%
West Asian: 7.8%
South Asian: 0.6%
Image (click for bigger)
Regarding haplogroup E and J those would be quite exotic in an Irish context, E is generally linked with Africans and Southern Europeans whereas J is extremely comon among Semetic population (Jews/arabs). As an Irish person if you don't test R1b highest probability would be haplogroup I. It does look that some names associated with the ruling families of the Ulad/Dál nAraide/Cruithne are haplogroup I.
|24-01-2011, 15:12
I'd expect my results to be M222; as my surname originated in Galway (like you said earlier the range of M222 goes beyond the UiNiall).
Is there a point where the irish clusters intersect? A common ancestor outside of Ireland, if you will.
|24-01-2011, 15:27
Join Date: May 2002
Location: D�n Laoire, Bl�th Cliath, �ire
Posts: 2,760
Until testing becomes more common in Europe (including Ireland) it's going to be hard to get a broader view. Currently the picture is alot more detailed then it was 5 years ago. Back then the major SNP groups in R1b hadn't been discovered. I can imagine that in 5 more years that our imagine of the Haplogroup tree will be even more different.
M222 is a good example of "dominant male replacement". In that you could get a small population of warrior invaders who due to higher social standing (been conquerors) end up swamping the local male population over multiple generations. What happens is they have more male children who survive to adulthood. A good example given on M222 is that one of the Kings of Tír Chonnail in the 15th century (Ó Domhnaill) had 15 surviving male children from 3-4wives.
As a result 1 in 6 Irish men carry M222 even though it's only believed to have arisen about 1700-2000 years ago.
|24-01-2011, 15:38
Doesn't this also pose problems for future testing within Ireland? You gave an example of one king with 15 sons; if there isn't a "filter" inplace to take account of these instances won't the results be skewed in favour of these male lines?
|24-01-2011, 15:53
Join Date: May 2002
Location: D�n Laoire, Bl�th Cliath, �ire
Posts: 2,760
TBH the ruling dynasties of "Gaelic Ireland" are always going to be well represented. What potentially might happen in the future is that a new SNP is found that divides M222. For example there might be one that is only found in M222 men who have names connected with the Uí Briúin (O'Connor, O'Rourke, O'Malley, O'Flaherty etc.) so it's still worthwhile to test men who are M222. I think one thing that would be good is if we have more testing from people bearing "minor" names. What I mean is names that are not connected to kings etc. (my name would be an example: Duffy).
Here's an image from 2006 regarding Niall's purported STR signature. As you can see it reaches a peak in around Inishowen and in Connacht (Uí Briúin)
|Thanks from:
|24-01-2011, 16:18
I think I read somewhere that there are two O'Neill lineages; the "main" one and a Southern one. This ties in with your non parental event; probably down to someone adopting it due to allegiances etc
You mentioned the cruithne earlier; I read somewhere that they had links around Roscommon. Isn't this also the rough region where the Connachta hailed from?
What is known about the cruithne; anything I've read always seems to tie them to the Picts and also to p-celtic speaking groups. Also who were the Connachta and what kind of background did they claim?
|24-01-2011, 16:37
Join Date: May 2002
Location: D�n Laoire, Bl�th Cliath, �ire
Posts: 2,760
I think people get abit too hung up on the P/Q celtic divide. Looking at Welsh now obviously it seems quite alien compared to Irish but when you understand the orthographical differences you can see words that have common meanings. They reckon that the spilt between Irish and Welsh could be about 2,500 years, given that neither was written for a further 1,000 years it's not surprising that they look different, but in sense the basic P/Q divide is like the "High German" shift. For example Dutch only shifted th ->d but it didn't do for example d -> t (English: day, Dutch: Dag, German: Tag) or t -> ss (english that, German dass
As for Cruithne I can't really comment as I don't know enough though the medieval Dal nAirde are purported to be their successors. If they had originally been p-celtic then they had undergone language shift. Given the closeness of the two languages at the time this wouldn't have been too hard (lot easier then shifting Irish to English for example).
The Connachta if you believe the ancient Genealogists are descended from Conn Cétchathach (Conn of the 100 battles). Who supposedly lived in the 2nd century around the time of Marcus Aurelis and who ruled the northern half of Ireland (line from Galway to Dublin) as Leath Cuinn (Conn's half). The southern half (leath Mugh) been ruled by the ancestor of the Éoganacht: Mug Nuadat
However alot of Irish history at this stage is purely conjucture if not outright mythology in it's own way. It would seem that the history books were rewritten by the Uí Neill for dynastic propaganda.
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Fantastic Four Vol 1 521
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- You can't use my mojo because it's too... too human! I forget. You're not a giant man with a bad wardrobe. Not the giant part, anyway. Yes, you're big......but humanoid...nose, fingers, optic nerves, etcetera...is how my brain registers you so it doesn't melt down.
Appearing in "Rising Storm: Part 2"Edit
Featured Characters:
- Fantastic Four
Supporting Characters:
Other Characters:
- Brüm Nebula
- Rohkyn III
- Aquion
- Silocus
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Synopsis for "Rising Storm: Part 2"Edit
- Synopsis not yet written.
- This issue is reprinted in other comics and books, see references for more info.[1]
- No trivia.
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Recommended ReadingEdit
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NASA Juno Jupiter Mission
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Source: NASA


text:
Cost Sharing
Cost Sharing
Forms & Tools
Cost sharing is the portion of project costs not reimbursed by the sponsor and may be in the form of cash or in-kind contributions. In a proposal, cost sharing may be offered in response to a requirement from the sponsor (i.e., "mandatory cost sharing") or may be offered voluntarily (i.e., "voluntary cost sharing"). Cost sharing is most commonly required under federally-sourced grants.
What's essential
OMB Circular A-110 establishes the following criteria for cost sharing for federally-sourced awards:
- Verifiable from the recipient's records
- Not included as a contribution for any other federally-assisted program
- Necessary and reasonable for proper and efficient accomplishment of the project or program objectives
- Allowable under applicable cost principles
- Not paid by another federal award, except as authorized by statute
- Provided for in the approved budget when required by the federal awarding agency.
The Circular also spells out specific requirements and limits for determining the value of particular types of cost sharing (e.g., donations, volunteers, and loaned items).
Why it's important
Proposed cost sharing becomes a binding commitment once an award is made. Failure to fulfill the cost-sharing obligation at the level proposed results in the reduction of the amount of the sponsor's award. An RC-unit that pledges cost sharing is responsible for identifying and providing the resources for committed cost share.
How to comply
In the proposal:
- UNH strongly encourages limiting cost sharing to that which is mandated by sponsors. (It is worth noting that the National Science Foundation now prohibits voluntary committed cost sharing.)
- Principal Investigators are strongly encouraged to limit explicit commitment of effort contributed at no cost to the sponsor, especially in those instances where contributed effort is not a significant portion of the PI's total effort.
- Anticipated cost-sharing contributions from third parties should be documented in official subrecipient proposals or signed letters of commitment.
After the award:
- Cost sharing ordinarily should be expended at the same rate as the sponsored funds.
- Cost sharing should be monitored/documented/recorded throughout the duration of the project to make sure the proposed obligation is being fulfilled.
- Cost shared salaries must be charged to the project's cost sharing fund, as budgeted, to be allowable as cost sharing.
- Documentation of all cost sharing not documented in the cost-sharing fund must be maintained at the RC-unit.
Additional Information
Matching Funds represent a form of required cost sharing at a significant level, for example, two Federal to one non-Federal or one Federal to one non-Federal.
OMB Circular A-110 describes how to establish the value of non-cash contributions, such as:
- The cost shared value of volunteers should be consistent with what UNH pays for similar work. When the required skills have no comparator within UNH, rates must be consistent with those paid for similar work in the New Hampshire labor market and can be estimated using resources such as Independent Sector.
- The estimated value of donated equipment for which title passes to UNH may differ according to the purpose of the federal award. If the purpose of the award is to assist in the acquisition of equipment the total value of the donated equipment may be claimed as cost sharing; however, if the purpose of the award is to support activities that require the use of the equipment, normally only depreciation or use charges for equipment may be claimed.
See also: Financial Management in the Managing Awards section of the Research Office website.
SPA Staff are available to assist with valuations and the application of University policy, which can be complex and require the exercise of informed judgment.
PI Essentials: Guidance Document #6
©2012 UNH Sponsored Programs Administration, adapted with permission from Massachusetts Institute of Technology Office of Sponsored Programs
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These delectable moong dal stuffed chillies can double up as elegant starters and also make a great side vegetable when served with dal and rice. Bhavnagri chillies are a large variety of mild green chillies. You can substitute these chillies with capsicum if you like!
Preparation Time: 15 mins.   Cooking Time: 30 mins.
Serves 4 to 6.
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Non spicy green chillies stuffed with moong dal mixture Cooked on a non stick pan.
I added some lime juice to the moong daal mixture.
Turned out very nicely.
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Unions are often criticized for putting their members' interests above the needs of children. That's true, but this e-mail reveals that the union puts its own financial interests ahead of the financial well-being of its members.
The only question is, what will teachers do about it? Will they continue to pay the dues and blame the evil taxpayers for not "putting up" or will they grab the union leaders by the nape of the neck and tell them to get real?
Kyle is founder of Education Action Group and EAGnews.org, a news service dedicated to education reform and school spending research, reporting, analysis and commentary.
He is co-author of Glenn Beck's "Conform: Exposing the Truth About Common Core and Public Education," available at Amazon.com.
Kyle is a contributor to Townhall.com.
He has made appearances on the Fox News Channel, The Blaze, Fox Business Network, NPR and MSNBC. Kyle has given scores of interviews on talk radio programs coast to coast.
Kyle likes talking about his family, as well as his favorite music. Bob Dylan, Mark Knopfler, Neil Young and Johnny Cash are at the top of the list. He has attended 25 Bob Dylan shows.
Kyle can also be found on Facebook and Twitter.
TPP Would Authorize Obama to Set $15 Minimum Wage, Card Check, and CO2 Emissions Regulation—All By Executive Fiat | Michael Hammond
McCain: Let's face it, Trump's rhetoric is turning Muslims all over the world against us | Allahpundit


text:
Possible Duplicate:
how to take backup of a single table in the mysql database?
I have table on MySQL server and would like to get the SQL that would re-create the table.
How do I get the query to recreate the SQL table?
I have table on MySQL server and would like to get the SQL that would re-create the table.
How do I get the query to recreate the SQL table?
mysqldump can do it - http://dev.mysql.com/doc/refman/5.1/en/mysqldump.html
You can use it like this:
MySQL supports
From their docs:
This can be useful if you have just a connection to the DB, versus a CLI on the server. If you have a CLI, use mysqldump like liamgriffiths recommends.
If you are using phpMyAdmin, select a table then click the 'Export' tab. One of the output types is SQL. Selecting this will generate a SQL script to create the table and insert all of the data that is currently in the table. Make sure under the dump data option to select 'Structure and Data'
mysqldump [OPTIONS] database [tables]>backup-file.sql
If you don't give any tables or use the --databases or --all-databases, the whole database(s) will be dumped.
You can get a list of the options your version of mysqldump supports by executing mysqldump --help.
Note that if you run mysqldump without --quick or --opt, mysqldump will load the whole result set into memory before dumping the result. This will probably be a problem if you are dumping a big database.
If you have access to phpMyAdmin, you can get this code through the Export tab on the table that you require.
Select SQL then make sure you export "Structure" ("CREATE table" code) and "Data" ("INSERT" code) with Export type set to "INSERT".
I'd go with @liamgriffiths proposal of


text:
Property is in demand due to reduced inventory, as there are more potential buyers than sellers. Bidding wars with other buyers are possible, and listings begin to sell at greater than the asking price.
Not enough data to determine market type. Consult a local REALTOR® for up-to-date market summaries
The average home price in 56514 is $144,950, which is 3% higher than the average sold price in 56514 ($140,739) . The average home price per square foot in 56514 is $83 and about 3% of all homes in 56514 sold in the last 6 months. For 56514 home values, real estate prices, and city market trends, research the 1,321 property records or search our 39 recently sold or 26 homes for sale listings. The listings and properties in 56514 are only a part of the 1,795,270 properties and 52,670 homes for sale in Minnesota. Because of this, the average home price and average home value of 56514 also influence the average home price $159,900 and average sale price $189,000 of Minnesota. Listing counts, 56514 home prices and home values in 56514 are sourced daily from listing and property data on realtor.com®, which is the most up-to-date and accurate aggregation of real estate listings in the industry and includes approximately 800 regional MLSs and is the official website of the National Association of Realtors®.


text:
Sri Srinivasa Perumal Temple
Lots of Vishnu images
What we say:
This Hindu temple in the heart of Little India dates back to 1855 but had a much humbler appearance before the five-tier Gorupam roof was added in the 1960s.
If you look carefully at the carvings you'll see many representations of Vishnu, the preserver of the universe and god the temple is dedicated to, plus his female consort Lakshmi and eagle sidekick Garuda.
This temple is the starting point for the annual Thaipusam festival, a show of extreme religious devotion through self-mutilation and painful tasks.
More details397 Serangoon Rd
Opening Hours: Daily 06:30-12:00, 18:00-21:00
Tanya Procyshyn is a Singapore-based freelance writer and photographer. With a passion for unusual destinations, she has camped alongside Komodo dragons and shook hands with soldiers in North Korea. She blogs at www.idreamofdurian.com.
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Sri Srinivasa Perumal Temple map
Sri Srinivasa Perumal Temple
397 Serangoon Rd
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Sights in Downtown Singapore
Armenian Church
ArtScience Museum
Asian Civilisations Museum
Buying duty free in Singapore city
Chettiar Temple
Chinatown Heritage Centre
Chinatown Street Market
Civil Defence Heritage Gallery
DBS Arts Centre
Esplanade Theatres on the Bay
Everton Park
Fort Canning Park
Gardens by the Bay
Hajjah Fatimah Mosque
Kwan Im Thong Hood Cho Temple
Leong San Temple
Marina Barrage
Markets in SIngapore
Merlion Park
National Design Centre
National Museum of Singapore
Orchard Road Christmas Light Up
Peranakan Museum
Pulau Ubin
Red Dot Design Museum
Sakya Muni Buddha Gaya Temple
Singapore Art Museum
Singapore Botanic Gardens & National Orchid Garden
Singapore Flyer
Sri Krishnan Temple
Sri Mariamman Temple
Sri Srinivasa Perumal Temple
Sri Veeramakaliamman Temple
St Andrew's Cathedral
Sultan Mosque (Masjid Sultan)
Sungei Road Thieves Market
Tekka Centre Market
The Istana
The Substation
Thian Hock Keng Temple
URA Singapore City Gallery
Wak Hai Cheng Bio Temple (Yueh Hai Ching Temple)
The above sights are all the sights in Downtown Singapore we list on Travelfish.org.


text:
RENO, Nev. (AP) - Waste Management will be accepting some large items for free at its Reno and Stead transfer stations and the Lockwood landfill in honor of Earth Day and to try to curb desert dumping.
This weekend, the company will accept freon-free refrigerators and other large appliances, as well as chairs, sofas, mattresses and box springs for free at its transfer stations in Reno and Stead. Other household goods will be accepted at a reduced rate on those days.
Free residential dumping for almost all materials at the Lockwood landfill will be April 15-17, April 29-30 and May 1.
A company spokesman says the offer will help keep thousands of yards of waste and bulky items from being dumped illegally in the desert.
Copyright 2015 Associated Press. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.


text:
The Top 10 In Action Sports
01Kenton Cool And The Legend Of Everest
02The Martyn Ashton Interview: Meet the Man Who Got Back on the Bike
03Legends Behind the Lens: The Dan Milner Interview
04We Asked Surf Star Coco Ho For Her Step-by-Step Guide to the Basics
05The Tony Hawk Interview: How Is The Birdman Still Flying High After All These Years?
06We Toured Britain's Action Sports Hotspots With The New Ford S-MAX
07The Legend Of El Dorado: One Man's Obsession With Finding A City Made Of Gold
08I Am Legend: How Audiences – Real Or GoPro'ed – Can Affect Your Mind And Performance
09Watch A Freerunning King Defy The Laws Of Gravity In This Urban Assault On London
10Living On The Blood and Urine of Dead Sea Turtles: The Shocking Story of A Sailor Stuck in Hell
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Do you get a gift for your kids teacher?
Yes, usually gift cards, candles, ornaments, or handmade gifts.
Usually. This year they each got a really pretty Santa ornament.
I make fudge for Helena's teachers.I think this year we'll do cookies instead.Not sure yet!
Yes, something like a scarf and glove set. Thats what i get every year.
not anymore since they are in high school and each have 6 to 8 teachers apiece
Yup, I sure did. I love that pair of jeans I bought for myself.
We homeschool, so when I buy something for myself it is for their teacher as well. LOL


text:
ClassicsOnline Home » Chamber Music - MOZART, W.A. / DUTILLEUX, H. / IBERT, J. / RAVEL, M. (A Portrait) (Ensemble Pyramide)
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Articles tagged "Jeff Cumberland"
Sanchez Butt Fumble Symbolized Big Problems in New York Jets Pass Game
Mark Sanchez's famous Butt Fumble in 2012 was a symptom of a much larger problem. The episodic circus that is Rex Ryan and the New York Jets is working to improve the many, many lumps in their passing game in 2012.
Captain Comeback: 2012 NFL Rookie QBs Make More History
Captain Comeback Scott Kacsmar looks at the four rookie quarterbacks who combined for three comeback wins this week, while Tony Romo sets a Dallas record, and the Packers close out Detroit again.
Captain Comeback Week 13: Colts, Steelers Rally to Build Familiar AFC Race
Captain Comeback Scott Kacsmar shares tweets, records and has a "Todd Bowles Movement" in this monster edition highlighted by the clutch wins for annual AFC powerhouses Pittsburgh and Indianapolis.
Quick Outs
- Quality Stats Super Bowl Breakdown: Patriots vs Seahawks
- Super Bowl XLIX Prop Bets: Full List
- Super Bowl 49 Game Capsule: Patriots @ Seahawks
- Awesome: Must-see Super Bowl Hall of Shame Infographic
- Referee Bill Vinovich Gets The Nod For Super Bowl 49 -- Balls
- 2014 NFL Divisional Playoffs Most-Watched Evah!
- CHFF's Pat Imig Talks Stan Kroenke & The Rams on Sportsnet 590 Toronto
- NFL 2014 Playoff Seeds and Schedule
- Cold Hard Football Facts Quality Stats: Perfect 4-0 In Wild Card Weekend
- Vegas Win Totals For Each NFL Team
Team Pages


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death lord by thatnickidWatch
©2011-2015 thatnickid
undead grunts com out of the folds of his cloak made of shadows
in the bright areas of his body has souls wizsing through it
in the bright areas of his body has souls wizsing through it
ooohh your came out awesome!!....better then mine
I really like this one. It's different from a lot of other enteries. Very original and I can imagine fighting this one in Telara (of course we'd win, though it's gigantic! We'd get lots of great loot and stuff!)
its suppose to have souls flowing throw the light on his body but just didnt have time and i wanted like grunts to come out of him but if he is made i bet youl beet him
I swear I've seen this somewhere before... can't quite put my finger on it.
Its epicc!!~~~
Gooood job!~
Gooood job!~
rawr thnx
please zoooooom in


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i can only speak for myself, but i always develop the paper to completion. the times and contrast may vary but not the development. different papers may call for different times; ie. ilford's cooltone time are different than the standard rc papers. some warmtone papers may require betwen 2-3 minutes, but that time is determined before the exposure and doesn't vary.
just watching the print in the developer and pulling when "one thinks" it is ready, IMHO, is a poor method for learning. watch the clock.
learning to print by "instinct" comes from lots of practice and experience, it isn't something that just comes to mind out of the blue.


text:
Product Information:
Product Details
Special Offer:
15 Issues of Wine Spectator
Included with purchase ($10 value).
Weights & Dimensions
|Knob Type: Novelty Knob
|Style: French country
|Shape: Abstract
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Primary Material: Other
|Number of Items Included: 1
Weather Resistant: Yes
|Tarnish Resistant: Yes
|Rust Resistant: Yes
|Oxidation Resistant: Yes
|Corrosion Resistant: Yes
|Hinge Included: No
|Drawer Slides Included: No
|Fasteners Included: Yes
|Commercial Use: Yes
|Country of Manufacture: Mexico
Installation Required: Yes
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Exclusive: Joshua Jackson, Anna Torv Likely to Skip 2013 Pilot Season After Fringe Wraps
If you were counting on seeing Joshua Jackson or Anna Torv jump right into another TV role after Fringe wraps its series finale, you might want to take residence in the alt universe. Because both actors tell TVLine they likely will sit out the coming pilot season. READ MORE


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1991 Mercedes Benz 300e • 240,000 miles
1991 300E mercedes, 4 dr sedan. I'm trying to replace the left front window regulator. I got it in, but it doesn't raise the window correctly. One side is higher than the other. There is a loose part, about six inches long that I don't know where it goes. When I took the old one out, I failed to note exactly where this part was. It's like it almost fell out. Do you have a diagram to show me where to put it? I feel so ignorant. Help videos seem to take it for granted that anyone can reattach the window to the regulator. I've repaired cameras, rebuilt an engine or two, even rebuilt a gm hydromatic transmission, but can't figure this one out. Help please!
December 2, 2011.
December 2, 2011.
Thank you, fixitmr, I thought of that last night, but decided it might be worth a few bucks not to have to do that. But, I think I will do that now. Don't want to wait. I appreciate your input, though.
Dec 2, 2011.
Dec 2, 2011.
And is it part of the regulator assembly you bought or something else in door?
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originally posted by: On7a7higher7plane
a reply to: mysterioustranger
Alright then wise guy, what if you don't think snakes exist?
Then you would ruin any snake conversations anyone was having.
originally posted by: whyamIhere
I was ask by a friend this very question...Of course I answered yes, but?
I started thinking about it and I had to ask myself...Why would they?
Background: I was a thirty year Atheist. I was Atheist when being Atheist wasn't cool.
I don't want this to be a religious thread. I want to explore why Atheist's even participate.
If somebody was discussing the existence of Santa Claus...I would just move on.
Here are some of my specific questions...
Do you think people of faith are uneducated or just dumb?
Does it bother you that people of faith seem to be happy and blissful?
Do you feel you are educating people who have been indoctrinated?
Some of you seem to believe in UFO's. Doesn't that require faith?
Atheism is on the rise. Have people just lost their faith?
Would you be willing to admit you have no proof whether God exists or not?
I appreciate you taking the time to read. This thread is not about Religion.
It is about Faith or lack there of.
This is a sensitive topic. Please be respectful if you choose to reply...
"Telling someone just to believe so they stop asking questions; is not the same as answering the question."
[feyth] Show IPA
confidence or trust in a person or thing: faith in another's ability.
belief that is not based on proof.
[trooth] Show IPA
noun, plural truths [troothz, trooths] Show IPA .
the true or actual state of a matter: He tried to find out the truth.
conformity with fact or reality; verity: the truth of a statement.
a verified or indisputable fact, proposition, principle, or the like.