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Professional Education
Doctor of Philosophy, Universitat Ulm (2010)
Stanford Advisors
Rajat Rohatgi, Postdoctoral Faculty Sponsor
All Publications
Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity.
2015; 521 (7550): 99-104
Whereas cancers grow within host tissues and evade host immunity through immune-editing and immunosuppression, tumours are rarely transmissible between individuals. Much like transplanted allogeneic organs, allogeneic tumours are reliably rejected by host T cells, even when the tumour and host share the same major histocompatibility complex alleles, the most potent determinants of transplant rejection. How such tumour-eradicating immunity is initiated remains unknown, although elucidating this process could provide the basis for inducing similar responses against naturally arising tumours. Here we find that allogeneic tumour rejection is initiated in mice by naturally occurring tumour-binding IgG antibodies, which enable dendritic cells (DCs) to internalize tumour antigens and subsequently activate tumour-reactive T cells. We exploited this mechanism to treat autologous and autochthonous tumours successfully. Either systemic administration of DCs loaded with allogeneic-IgG-coated tumour cells or intratumoral injection of allogeneic IgG in combination with DC stimuli induced potent T-cell-mediated antitumour immune responses, resulting in tumour eradication in mouse models of melanoma, pancreas, lung and breast cancer. Moreover, this strategy led to eradication of distant tumours and metastases, as well as the injected primary tumours. To assess the clinical relevance of these findings, we studied antibodies and cells from patients with lung cancer. T cells from these patients responded vigorously to autologous tumour antigens after culture with allogeneic-IgG-loaded DCs, recapitulating our findings in mice. These results reveal that tumour-binding allogeneic IgG can induce powerful antitumour immunity that can be exploited for cancer immunotherapy.
View details for DOI 10.1038/nature14424
View details for PubMedID 25924063
Location, location, and location: compartmentalization of Hedgehog signaling at primary cilia.
EMBO journal
2014; 33 (17): 1852-1854
View details for DOI 10.15252/embj.201489294
View details for PubMedID 25037564
EFCAB7 and IQCE Regulate Hedgehog Signaling by Tethering the EVC-EVC2 Complex to the Base of Primary Cilia
2014; 28 (5): 483-496
The Hedgehog (Hh) pathway depends on primary cilia in vertebrates, but the signaling machinery within cilia remains incompletely defined. We report the identification of a complex between two ciliary proteins, EFCAB7 and IQCE, which positively regulates the Hh pathway. The EFCAB7-IQCE module anchors the EVC-EVC2 complex in a signaling microdomain at the base of cilia. EVC and EVC2 genes are mutated in Ellis van Creveld and Weyers syndromes, characterized by impaired Hh signaling in skeletal, cardiac, and orofacial tissues. EFCAB7 binds to a C-terminal disordered region in EVC2 that is deleted in Weyers patients. EFCAB7 depletion mimics the Weyers cellular phenotype-the mislocalization of EVC-EVC2 within cilia and impaired activation of the transcription factor GLI2. Evolutionary analysis suggests that emergence of these complexes might have been important for adaptation of an ancient organelle, the cilium, for an animal-specific signaling network.
View details for DOI 10.1016/j.devcel.2014.01.021
View details for Web of Science ID 000333405600004
View details for PubMedID 24582806
A novel splice variant of calcium and integrin-binding protein 1 mediates protein kinase D2-stimulated tumour growth by regulating angiogenesis
2014; 33 (9): 1167-1180
Protein kinase D2 (PKD2) is a member of the PKD family of serine/threonine kinases, a subfamily of the CAMK super-family. PKDs have a critical role in cell motility, migration and invasion of cancer cells. Expression of PKD isoforms is deregulated in various tumours and PKDs, in particular PKD2, have been implicated in the regulation of tumour angiogenesis. In order to further elucidate the role of PKD2 in tumours, we investigated the signalling context of this kinase by performing an extensive substrate screen by in vitro expression cloning (IVEC). We identified a novel splice variant of calcium and integrin-binding protein 1, termed CIB1a, as a potential substrate of PKD2. CIB1 is a widely expressed protein that has been implicated in angiogenesis, cell migration and proliferation, all important hallmarks of cancer, and CIB1a was found to be highly expressed in various cancer cell lines. We identify Ser(118) as the major PKD2 phosphorylation site in CIB1a and show that PKD2 interacts with CIB1a via its alanine and proline-rich domain. Furthermore, we confirm that CIB1a is indeed a substrate of PKD2 also in intact cells using a phosphorylation-specific antibody against CIB1a-Ser(118). Functional analysis of PKD2-mediated CIB1a phosphorylation revealed that on phosphorylation, CIB1a mediates tumour cell invasion, tumour growth and angiogenesis by mediating PKD-induced vascular endothelial growth factor secretion by the tumour cells. Thus, CIB1a is a novel mediator of PKD2-driven carcinogenesis and a potentially interesting therapeutic target.Oncogene advance online publication, 18 March 2013; doi:10.1038/onc.2013.43.
View details for DOI 10.1038/onc.2013.43
View details for Web of Science ID 000331933800010
View details for PubMedID 23503467
Ric1-Rgp1 Complex Is a Guanine Nucleotide Exchange Factor for the Late Golgi Rab6A GTPase and an Effector of the Medial Golgi Rab33B GTPase
2012; 287 (50): 42129-42137
Rab GTPases are master regulators of membrane trafficking events and template the directionality of protein transport through the secretory and endocytic pathways. Certain Rabs recruit the guanine nucleotide exchange factor (GEF) that activates a subsequent acting Rab protein in a given pathway; this process has been termed a Rab cascade. We show here that the medial Golgi-localized Rab33B GTPase has the potential to link functionally to the late Golgi, Rab6 GTPase, by its capacity for association with Ric1 and Rgp1 proteins. In yeast, Ric1p and Rgp1p form a complex that catalyzes guanine nucleotide exchange by Ypt6p, the Rab6 homolog. Human Ric1 and Rgp1 both bind Rab6A with preference for the GDP-bound conformation, characteristic of a GEF. Nevertheless, both Ric1 and Rgp1 proteins are needed to catalyze nucleotide exchange on Rab6A protein. Ric1 and Rgp1 form a complex, but unlike their yeast counterparts, most of the subunits are not associated, and most of the proteins are cytosolic. Loss of Ric1 or Rgp1 leads to destabilization of Rab6, concomitant with a block in Rab6-dependent retrograde transport of mannose 6-phosphate receptors to the Golgi. The C terminus of Ric1 protein contains a distinct binding site for Rab33B-GTP, supporting the existence of a Rab cascade between the medial and trans Golgi. This study thus identifies a GEF for Rab6A in human cells.
View details for DOI 10.1074/jbc.M112.414565
View details for Web of Science ID 000312103000051
View details for PubMedID 23091056
RUTBC2 Protein, a Rab9A Effector and GTPase-activating Protein for Rab36
2012; 287 (27): 22740-22748
Rab GTPases regulate vesicle budding, motility, docking, and fusion. In cells, their cycling between active, GTP-bound states and inactive, GDP-bound states is regulated by the action of opposing enzymes called guanine nucleotide exchange factors and GTPase-activating proteins (GAPs). The substrates for most RabGAPs are unknown, and the potential for cross-talk between different membrane trafficking pathways remains uncharted territory. Rab9A and its effectors regulate recycling of mannose 6-phosphate receptors from late endosomes to the trans Golgi network. We show here that RUTBC2 is a TBC domain-containing protein that binds to Rab9A specifically both in vitro and in cultured cells but is not a GAP for Rab9A. Biochemical screening of Rab protein substrates for RUTBC2 revealed highest GAP activity toward Rab34 and Rab36. In cells, membrane-associated RUTBC2 co-localizes with Rab36, and expression of wild type RUTBC2, but not the catalytically inactive, RUTBC2 R829A mutant, decreases the amount of membrane-associated Rab36 protein. These data show that RUTBC2 can act as a Rab36 GAP in cells and suggest that RUTBC2 links Rab9A function to Rab36 function in the endosomal system.
View details for DOI 10.1074/jbc.M112.362558
View details for Web of Science ID 000306495000031
View details for PubMedID 22637480
Protein Kinase D Regulates RhoA Activity via Rhotekin Phosphorylation
2012; 287 (12): 9473-9483
The members of the protein kinase D (PKD) family of serine/threonine kinases are major targets for tumor-promoting phorbol esters, G protein-coupled receptors, and activated protein kinase C isoforms (PKCs). The expanding list of cellular processes in which PKDs exert their function via phosphorylation of various substrates include proliferation, apoptosis, migration, angiogenesis, and vesicle trafficking. Therefore, identification of novel PKD substrates is necessary to understand the profound role of this kinase family in signal transduction. Here, we show that rhotekin, an effector of RhoA GTPase, is a novel substrate of PKD. We identified Ser-435 in rhotekin as the potential site targeted by PKD in vivo. Expression of a phosphomimetic S435E rhotekin mutant resulted in an increase of endogenous active RhoA GTPase levels. Phosphorylation of rhotekin by PKD2 modulates the anchoring of the RhoA in the plasma membrane. Consequently, the S435E rhotekin mutant displayed enhanced stress fiber formation when expressed in serum-starved fibroblasts. Our data thus identify a novel role of PKD as a regulator of RhoA activity and actin stress fiber formation through phosphorylation of rhotekin.
View details for DOI 10.1074/jbc.M112.339564
View details for Web of Science ID 000301797800076
View details for PubMedID 22228765
Protein kinase D2 is a novel regulator of glioblastoma growth and tumor formation
2011; 13 (7): 710-724
Glioblastoma multiforme, a highly aggressive tumor of the central nervous system, has a dismal prognosis that is due in part to its resistance to radio- and chemotherapy. The protein kinase C (PKC) family of serine threonine kinases has been implicated in the formation and proliferation of glioblastoma multiforme. Members of the protein kinase D (PKD) family, which consists of PKD1, -2 and, -3, are prominent downstream targets of PKCs and could play a major role in glioblastoma growth. PKD2 was highly expressed in both low-grade and high-grade human gliomas. The number of PKD2-positive tumor cells increased with glioma grading (P < .001). PKD2 was also expressed in CD133-positive glioblastoma stem cells and various glioblastoma cell lines in which the kinase was found to be constitutively active. Inhibition of PKDs by pharmacological inhibitors resulted in substantial inhibition of glioblastoma proliferation. Furthermore, specific depletion of PKD2 by siRNA resulted in a marked inhibition of anchorage-dependent and -independent proliferation and an accumulation of glioblastoma cells in G0/G1, accompanied by a down-regulation of cyclin D1 expression. In addition, PKD2-depleted glioblastoma cells exhibited substantially reduced tumor formation in vivo on chicken chorioallantoic membranes. These findings identify PKD2 as a novel mediator of glioblastoma cell growth in vitro and in vivo and thereby as a potential therapeutic target for this devastating disease.
View details for DOI 10.1093/neuonc/nor084
View details for Web of Science ID 000293170900003
View details for PubMedID 21727210
Protein Kinase D2 Is an Essential Regulator of Murine Myoblast Differentiation
2011; 6 (1)
Muscle differentiation is a highly conserved process that occurs through the activation of quiescent satellite cells whose progeny proliferate, differentiate, and fuse to generate new myofibers. A defined pattern of myogenic transcription factors is orchestrated during this process and is regulated via distinct signaling cascades involving various intracellular signaling pathways, including members of the protein kinase C (PKC) family. The protein kinase D (PKD) isoenzymes PKD1, -2, and -3, are prominent downstream targets of PKCs and phospholipase D in various biological systems including mouse and could hence play a role in muscle differentiation. In the present study, we used a mouse myoblast cell line (C2C12) as an in vitro model to investigate the role of PKDs, in particular PKD2, in muscle stem cell differentiation. We show that C2C12 cells express all PKD isoforms with PKD2 being highly expressed. Furthermore, we demonstrate that PKD2 is specifically phosphorylated/activated during the initiation of mouse myoblast differentiation. Selective inhibition of PKCs or PKDs by pharmacological inhibitors blocked myotube formation. Depletion of PKD2 by shRNAs resulted in a marked inhibition of myoblast cell fusion. PKD2-depleted cells exhibit impaired regulation of muscle development-associated genes while the proliferative capacity remains unaltered. Vice versa forced expression of PKD2 increases myoblast differentiation. These findings were confirmed in primary mouse satellite cells where myotube fusion was also decreased upon inhibition of PKDs. Active PKD2 induced transcriptional activation of myocyte enhancer factor 2D and repression of Pax3 transcriptional activity. In conclusion, we identify PKDs, in particular PKD2, as a major mediator of muscle cell differentiation in vitro and thereby as a potential novel target for the modulation of muscle regeneration.
View details for DOI 10.1371/journal.pone.0014599
View details for Web of Science ID 000286663900004
View details for PubMedID 21298052
Modulation of Calcium-Activated Potassium Channels Induces Cardiogenesis of Pluripotent Stem Cells and Enrichment of Pacemaker-Like Cells
2010; 122 (18): 1823-?
Ion channels are key determinants for the function of excitable cells, but little is known about their role and involvement during cardiac development. Earlier work identified Ca(2+)-activated potassium channels of small and intermediate conductance (SKCas) as important regulators of neural stem cell fate. Here we have investigated their impact on the differentiation of pluripotent cells toward the cardiac lineage.We have applied the SKCa activator 1-ethyl-2-benzimidazolinone on embryonic stem cells and identified this particular ion channel family as a new critical target involved in the generation of cardiac pacemaker-like cells: SKCa activation led to rapid remodeling of the actin cytoskeleton, inhibition of proliferation, induction of differentiation, and diminished teratoma formation. Time-restricted SKCa activation induced cardiac mesoderm and commitment to the cardiac lineage as shown by gene regulation, protein, and functional electrophysiological studies. In addition, the differentiation into cardiomyocytes was modulated in a qualitative fashion, resulting in a strong enrichment of pacemaker-like cells. This was accompanied by induction of the sino-atrial gene program and in parallel by a loss of the chamber-specific myocardium. In addition, SKCa activity induced activation of the Ras-Mek-Erk signaling cascade, a signaling pathway involved in the 1-ethyl-2-benzimidazolinone-induced effects.SKCa activation drives the fate of pluripotent cells toward mesoderm commitment and cardiomyocyte specification, preferentially into nodal-like cardiomyocytes. This provides a novel strategy for the enrichment of cardiomyocytes and in particular, the generation of a specific subtype of cardiomyocytes, pacemaker-like cells, without genetic modification.
View details for DOI 10.1161/CIRCULATIONAHA.110.971721
View details for Web of Science ID 000283670800013
View details for PubMedID 20956206
Protein kinase D2 is a crucial regulator of tumour cell-endothelial cell communication in gastrointestinal tumours
2010; 59 (10): 1316-1330
Tumour angiogenesis is crucially dependent on the communication between the tumour and the associated endothelium. Protein kinase D (PKD) isoenzymes mediate vascular endothelial growth factor-A (VEGF-A) induced endothelial cell proliferation and migration and are also highly expressed in various tumours.To examine the role of PKDs for tumour proliferation and angiogenesis selectively in pancreatic and gastric tumours and in tumour-associated endothelium in vitro and in vivo.PKD2 expression in human tumours was determined by immunohistochemistry. The effect of PKD2 depletion in endothelial cells by siRNAs was examined in sprouting assays, the chorioallantois model (CAM) and tumour xenografts. In murine endothelium in vivo PKD2 was knocked-down by splice switching oligonucleotides. Human PKD2 was depleted in xenografts by siRNAs and PKD2-miRs. PKD2 activation by hypoxia and its role for hypoxia-induced NR4/TR3- and VEGF-A promoter activity, expression and secretion was investigated in cell lines.PKD2 is expressed in gastrointestinal tumours and in the tumour-associated endothelium. Tumour growth and angiogenesis in the CAM and in tumour xenografts require PKD expression in endothelial cells. Conversely, hypoxia activates PKD2 in pancreatic cancer cells and PKD2 was identified as the major mediator of hypoxia-stimulated VEGF-A promoter activity, expression and secretion in tumour cells. PKD2 depletion in pancreatic tumours inhibited tumour-driven blood vessel formation and tumour growth in the CAM and in orthotopic pancreatic cancer xenografts.PKD2 regulates hypoxia-induced VEGF-A expression/secretion by tumour cells and VEGF-A stimulated blood vessel formation. PKD2 is a novel, essential mediator of tumour cell-endothelial cell communication and a promising therapeutic target to inhibit angiogenesis in gastrointestinal cancers.
View details for DOI 10.1136/gut.2009.206813
View details for Web of Science ID 000282661300006
View details for PubMedID 20732914
Role of the Second Cysteine-rich Domain and Pro275 in Protein Kinase D2 Interaction with ADP-Ribosylation Factor 1, Trans-Golgi Network Recruitment, and Protein Transport
2010; 21 (6): 1011-1022
Protein kinase D (PKD) isoenzymes regulate the formation of transport carriers from the trans-Golgi network (TGN) that are en route to the plasma membrane. The PKD C1a domain is required for the localization of PKDs at the TGN. However, the precise mechanism of how PKDs are recruited to the TGN is still elusive. Here, we report that ADP-ribosylation factor (ARF1), a small GTPase of the Ras superfamily and a key regulator of secretory traffic, specifically interacts with PKD isoenzymes. ARF1, but not ARF6, binds directly to the second cysteine-rich domain (C1b) of PKD2, and precisely to Pro275 within this domain. Pro275 in PKD2 is not only crucial for the PKD2-ARF1 interaction but also for PKD2 recruitment to and PKD2 function at the TGN, namely, protein transport to the plasma membrane. Our data suggest a novel model in which ARF1 recruits PKD2 to the TGN by binding to Pro275 in its C1b domain followed by anchoring of PKD2 in the TGN membranes via binding of its C1a domain to diacylglycerol. Both processes are critical for PKD2-mediated protein transport.
View details for DOI 10.1091/mbc.E09-09-0814
View details for Web of Science ID 000275433500016
View details for PubMedID 20089835


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Graphical shells
The Hotwire shell removes the complexities of interactive consoles. We'll show you how to Hotwire your Linux with this handy text and graphical shell for developers and administrators.
Hotwire is an intelligent, hybrid text and graphical shell for developers and administrators . According to developer Colin Walters, Hotwire "… is intended to replace the interactive command-line portion of a typical Unix shell." Hotwire combines the functions of a terminal window, a shell, and many of the familiar command-line utilities. One interesting feature of Hotwire is its ability to separate input and output streams. But is Hotwire truly more than just a shell? I decided to investigate.
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Photon Controller Goes Open Source
VMware bids for a stake in the container industry with a bold effort to integrate containers with its classic virtualization system.
New Point-and-Click Exploit Kit Appears in the Wild
3ROS attack tool lowers the technical bar so anyone can be an intruder.
Firefox Finally Gets Tracking Protection
Mozilla's latest browser offers powerful new privacy feature
New Password Looter Tool Steals Passwords from a Password Manager
If attackers are on your system, saving your passwords in a password vault is no protection.
Over a Million Websites Are Still Using SHA-1
Faulty hash algorithm persists, despite efforts by experts to raise awareness.
Dyreza Malware is Back
Powerful man-in-the-middle attack is now targeting online shopping.
Kernel Developer Matthew Garrett Forks the Linux Kernel
Another high-profile coder says the kernel team needs a kinder, gentler culture.
Bugzilla Bug
Bug database has a bug of its own that could allow an intruder to create an unauthorized account.
US Launches New Strategy for Broadband Access
Report focuses federal resources on achieving universal Internet access.
RC4 Finally Gets the Fork
Leading browser makers say "no" to porous encryption algorithm


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Todd Spitzer Dinged By Republican Blog
Categories: Carona Watch, Moxley, OC Media, Politics
|The past haunts Spitzer
The folks at the Friends for Fullerton's Future (FFF) blog slammed Spitzer for his past service on the board of supervisors, and it wasn't pretty.
Spitzer hails himself as a good government activist but, as the FFF blog notes, during his prior stint as a supervisor he voted for two of the most controversial measures in modern county history:
1. Allowing certain government workers to retire at the age of 50 and collect 90 percent of their top salary for the rest of their lives.
2. Allowing Sheriff Mike Carona to drop all professional law enforcement hiring standards to name as his powerful assistant sheriffs Don Haidl, a shady businessman, and George Jaramillo, another dubious character.
(Surely, I don't need to remind you that Carona, Haidl and Jaramillo are all now convicted felons, right?)
"[Spitzer] assures us he has the experience we need in a county supervisor," FFF writes. "Guess Spitzer figures nobody's been paying attention. He is wrong."
At the moment, it looks like Spitzer's fellow Republican opponent in the race will be Chuck DeVore, the former state assemblyman who ran an unsuccessful campaign to win the Republican nomination to run against U.S. Senator Barbara Boxer in the last election.
Read the FFF blog post on Spitzer HERE.
--R. Scott Moxley / OC Weekly
Sponsor Content


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I normally am not a big poster but am always reading and trying to learn more from people on here. Well I thought I would share my big news... I bought myself a horse on Monday... this is my first horse.
How does one introduce their horse? Hmm lets see..
Name: Great Gun Deal
Barn Name: Lionel
DOB: May 8th, 2010
Colour: Buckskin
Markings: 4 White Socks, Huge White Blaze, 2 Blue Eyes
Lionel is by Gun Dealer (NRHA 2010 Limited Open World Champion) who I absolutely love! Hopefully Lionel will take after his daddy in looks and personality, so far so good. For a 3 year old he is really calm and quiet, you wouldnt think he was still a colt (was left a colt for resale value but now that I bought him he will be gelded after the show season).
I don't think it really has set in that I own him as he is still in training and will be shown in a couple futurities this year if he is ready. So I will not be riding him until he turns 4 and he will still be shown by my trainer when he is 4, and I will start showing him when he is 5 in Green as Grass.
What else does a person say about a horse that she has seen born and raised but has only own for 3 days?
I cannot post pictures on here right now but will be adding a few. I have a picture of him in my barn (please excuse the sweat marks, I took a quick photo after my trainer unsaddled him before he was groomed) Hopefully the weather up here gets really nice and I can get some nice pictures of the two of us.


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Mine is next week and I am so worried the tech will slip! I have also heard they write it down for the Dr. What if his office slips? Why does he need to know the gender? What have you done in the past to make sure your baby's secret is kept?
Comments (9)
fingers crossed ladies!! Seriously does it make a difference to the doctor what the sex is? Why do they need to know?
I would specifically ask the tech not to write the gender. Mine didn't at my old ob office or at this one. They see so many patients, I wouldn't count on someone not slipping, even if it was in my file that I didn't want to know.
I had to see a perinatologist for my NT scan with DS because my ob's office didn't do them. He slipped, and then tried to play it off like he was joking. They don't need to know. Before u/s, no one knew. Why would it all of a sudden become necessary?
Stacey-37, DH-36
ok Ill askthem not to even write it down, thank you for the advice. SMR that was my thoughts, there is no medical need to know the sex, it's not going to change how we deliver!!
Also, with DS, we had to remind EVERYONE that we dealt with in the ob's office that we didn't want to know, EVERY time, as soon as they walked in the room. It was exhausting. I'm happy they just didn't even document it anywhere with this baby.
Stacey-37, DH-36
I just joined this group. I had my u/s today. The tech didn't write it down anywhere and said even the doctor won't know. She said she knew and would forget in a minute anyway. Plus I won't see her again, they got all the measurements in one go this time.


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When it comes time for you, your family, and guests to walk outside, you may want to have an outdoor setting available. Wayfair can provide many different ways for you to enjoy a relaxing Friday evening with your family and friends. You can get a grill, patio furniture, and patio umbrellas and other outdoor décor. You might be able to some extra cash on the outdoor furniture, décor, and other items just by redeeming Wayfair promo codes. Therefore, if you ready to change your outdoor setting, Wayfair just may have what you are looking for.


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lady baltimore times square short sleeve crew tee
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Historic house built circa 1750 set in its own private parklands within the boundaries of Ennis Urban area. Furnished with antiques along with modern facilities. Large guest library. Genealogy assistance privided.
Sandycove House
Hillcrest Country Home Bed and Breakfast. A warm welcome awaits you at HILLCREST COUNTRY HOME BED AND BREAKFAST ADARE . Hillcrest Bed and Breakfast accommodation in Adare, County Limerick is a hospitable, relaxed home, situated amidst beaut
Situated right in the heart of Doolin and open all year round, we are able to provide a place to stay and rest whilst you journey around this fascinating region of Ireland. You may even end up staying for longer than you think!
The White Heather Farmhouse Bed & Breakfast is located on 100 acres of farmland close to Kenmare town, in a picturesque quiet area with stunning mountain views. Ideal location for walkers and those wishing to experience a real working farm.
4 star Glocca Morra B&B is situated in Ogonnelloe, Killaloe, Co Clare, with breathtaking views of Lough Derg, is a superb location for the peace and quiet of the Irish countryside, and an ideal base for touring Clare, Limerick, Galway and Tipperary.
Beautiful stone built house with wonderful views of both the countryside and the sea, on an elevated site, mature landscaped gardens. All rooms are en-suite, the property offers a hot tub, sauna and gym. We are open all year. Self-catering available.
Superb family run Bed and Breakfast accommodation set on 1.5 acres of wonderfull mature gardens, just 5 mins walk from the beautiful heritage twin towns of Ballina/Killaloe. Take the time to enjoy a relaxing stay at our award winning accommodation.
Armada Hotel is located on the beautiful coast of West Clare in Ireland overlooking the Atlantic ocean. A 4 star award winning hotel and within close proximity to Cliffs of Moher, the Burren, Aran Islands, Doonbeg and Lahinch Golf Courses
Ireland Accommodation: Bed & Breakfasts
Ireland Accommodation: Bed & Breakfasts
Ireland Accommodation: Bed & Breakfasts
Find a bed and breakfast in Abbey Ireland for your romantic weekend getaway. Intimate b & bs are cozy, romantic accommodations that are perfect for a mini-vacation, honeymoon, or wedding anniversary celebration. You will love the unique charm of our inns in Abbey Ireland. Many guesthouses include complimentary breakfasts and unbeatable hospitality. Browse our bed & breakfasts and plan your Abbey Ireland romantic getaway today!


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Kids Kondo
Preschool | Grades PK
Atlanta, GA 30306
(404) 897-1936
About This School
Kids Kondo is located in Atlanta, GA. It is a preschool that serves children ages 0-4. Kids Kondo is Independent and has a capacity of 84 children.
Kids Kondo offers instructional programs in reading and math.
Kids Kondo offers instructional programs in reading and math.
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1999 Chevrolet Suburban • V8 4WD Automatic • 130,000 miles
I have a 8 cylinder 7.4L suburban. A friend had vehicle in drive but not moving and engaged 4wd. What kinds of problems could result from doing this? The shop said I needed rear axle housing 3/4 ton w/9.5" ring gear, transmission, and a transfer case to be replaced with used parts. I am wondering what could have occurred by just pressing the 4wd button while the vehicle was not moving but in drive. Please let me know if this sounds right.
July 1, 2011.
July 1, 2011.
Is it possible to cause those types of damage just by attempting to engage 4wd while in drive at a standstill?
Jul 2, 2011.
Jul 2, 2011.
Would the transfer case switch being bad cause damages to the rear axle housing ring gear and transmission?
Jul 3, 2011.
Jul 3, 2011.
My Transfer Case has a bad oil pump, in it, and the truck itself won't shift when driving in 2 wheel drive, but when I put it in 4 Low it will shift up to 3rd gear. It will not shift ...
1 answer • 1993 Ford F-150 • 150,000 miles
My 97 ford explorer 5 sped manual trans 4x4 part time has a bad transfer case. The one I that it currently has on it ends in 195ga. I was able to get a case ending in CA. it has a 4 ...
1 answer • 1997 Ford Explorer • 174 miles
Enter your question...I have a 2003 Dodge Ram 1500 4x4. I have a few concerns about it. I think either the transfer case or something is going out. I was driving it in 4Low and every ...
2 answers • 2003 Dodge Ram • 147,000 miles
2 questions; Both on a cadillac escalade transfer case with full time all wheel drive; I drained & refilled it with the blue ''auto track II'' gm stuff that my gmc truck takes, then ...
3 answers • 2002 Cadillac Escalade • 150,000 miles


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User Reviews for Emla
The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.
Learn more about Emla.
Reviews for Emla to treat Anesthesia
"Emla will do the job..for only half hour! It takes like 2 hours when you apply and you can't count on it more than 30-40 mins. If you wanna use Emla for a tattoo, anything bigger than the palm of your hand won't do the job! A little cute butterfly? Buy this product, you'll love it! A big rib piece? You better hold the pain and cry and faint than counting on this cream! And I do NOT know if you can re-apply some during the tattoo session. Just be aware that if the pain comes back and your tattoo is not over-your brain will freak out at least 6-7 times more and so as the pain! This product can be a b*tch if you want to use it on a $200 tattoo."
wowavalidnicknamehahaha August 16, 2015
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"I use Emla with a dermaroller. I apply a thin layer and put cling film over it for 60 minutes before starting treatment. It completely numbs the area and I can't feel the 1.5mm needles at all. I can now get thru a session in 5 minutes instead of 30 where I had to keep stopping cause of pain. I bought this for just over $20 for a 5mg tube at Chemist Warehouse. It's expensive but I only need one every 6 weeks and 5g covers my whole buttock and thigh area. I love this stuff!"
Ree1990 October 28, 2013
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"Without Emla cream I don't know how I would have made it through my cancer treatments...Thank you so much. I am now finding it impossible to find Emla. My pharmacy have told me it has stopped being manufactured...is this true...Please say NO."
Anonymous (taken for 10 years or more) May 23, 2012
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Monee Elementary School
Public School | Grades K-5 | Crete Monee CUSD 201U
Monee, IL 60449
(708) 367-2600
About This School
Monee Elementary School is located in Monee, IL and is one of 5 elementary schools in Crete Monee Cusd 201u. It is a public school that serves 576 students in grades K-5. See Monee Elementary School's test results to learn more about school performance.
In 2011, Monee Elementary School had 19 students for every full-time equivalent teacher. The Illinois average is 16 students per full-time equivalent teacher.
In 2011, Monee Elementary School had 19 students for every full-time equivalent teacher. The Illinois average is 16 students per full-time equivalent teacher.
Student Ethnicity (2011)
Students (2011)
Students Per Teacher (2011)
Female/Male (2011)
48% 52%
Subsidized Lunch (2011)
District Spending (2010)
$11,020per student
See All Test Scores
All Grades Composite Performance
ISAT Results
write a review
Monee Elementary School Reviews
By a Parent on
I moved to Monee when I married my husband who already had a home here. I come from the rural community back east. I have been very disappointed by the parents lack of involvement in the school, but I find the teachers and staff wonderful. The school has had a lot of budget problems and for several years lacked art and P.E. These programs have been reinstated but may be eliminated again in 2011 due to budget problems.
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Disney announces WALL-E range for UK
Disney has announced its first-ever robotic products with the launch of a range of toys tying in with the Disney/Pixar animated film "WALL-E" to hit the shelves in early July, to tie in with the film's UK theatrical release.
Parents should prepare themselves for some serious pestering as it seems the company has left no stone unturned in its merchandise march on the UK.
The U-Command WALL-E is a remote control robot that can be programmed with thousands of different movement combinations and will cost £39.99.
With the ability to perform 360 degree turns, move in every direction and do a figure of eight, the poseable figure also features light-up eyes, real moving treads and speech functionality.
For £20, the iDance WALL-E dances in a "funky, bio-robotic style" to any music source. Complete with an audio in-jack working with any iPod or MP3 player to play tunes through his chest speaker, he also features light-up eyes and sound activation functionality.
The Interactive WALL-E and Interactive EVE robots feature voice and light-up functionality, with motorised head and arm movements. Both are fully poseable and can interact with each other and will go on sale for £29.99.
The BnL Truck Electronic Playset recreates WALL-E's home from the movie, and includes press-button features that activate a selection of character voices and phrases.
Four younger kids, the Magnetic Construct-a-Bots give wannabe robot-makers the chance to create their very own WALL-E and EVE. With a central body section housing a magnet, separate body parts can be added to create the two central characters from the film.
In addition, there's a plethora of themed stuff to tempt kids to spend their pocket money, including interactive and activity books, a 2009 annual, bedroom sets, lunch bags, beauty products, tissues, flashlights, and a collection of apparel, accessories, bags and footwear.
At internetmatters.org parents can find all the advice they will need to keep their children safe online. Designed specifically for parents, the site offers a wealth of up-to-date, unbiased information and advice about how to deal with online safety. Parents can learn about the latest issues and technologies, get great tips on how to talk about online safety with their children and get the best advice on dealing with issues and taking action. Created with experts, Internet Matters provides detailed information, but also signposts to best-in-class resources from individual expert organisations. Our goal is to ensure parents can always access the information that they need, in a format that is clear and concise.
Best gadgets you can buy right now: EE Pocket-lint Gadget Awards 2015 winners announced
EE Pocket-lint Gadget Awards 2015 voting closes today: Make sure you vote for your favourites
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- Now you can buy a computer for £4: Raspberry Pi Zero


text: Kiwi Hoons Perform Triple Burnout With El Camino, Nomination For Jalopnik Sainthood ConsideredBen Wojdyla and 77 othersEditDeleteInvite manuallyPromoteDismissUndismissBlock for jalopnikHide These Kiwi hoons pulled out a flatbed truck, topped it with a Ute, which itself is topped with a motorcycle in its bed. All three are doing burnouts. Epic win. »1/14/09 1:00pm1/14/09 1:00pm


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Posted| Updated
The Productivity Commission has recommended a simpler and broader child care system, but a lot needs to be done to ensure it is more available, more flexible and of high quality.
Topics: child-care, parenting, workplace, discrimination, budget
Posted| Updated
Only 21 per cent of mayors in Australia are female and 7 per cent are chief executive officers, the Australian Local Government Women's Association conference in Queensland has heard.
Topics: local-government, activism-and-lobbying, rural-women, women, discrimination, warwick-4370, toowoomba-4350
Posted| Updated
Sex Discrimination Commissioner Elizabeth Broderick details a case of a woman working for a large organisation who was told by her manager that her pregnancy was 'inconvenient' and suggested she terminate.
Topics: discrimination, pregnancy-and-childbirth, abortion, australia
Posted| Updated
Militant group Islamic State has ordered all girls and women in and around Iraq's northern city of Mosul to undergo female genital mutilation, the United Nations says.
Topics: world-politics, religion-and-beliefs, community-and-society, discrimination, sexual-health, child-health-and-behaviour, health, child-abuse, iraq, united-kingdom
Posted| Updated
AIDS survivor and activist says wiping out HIV will be easier than eliminating the stigma of living with the disease in the Pacific.
Topics: community-and-society, community-organisations, death, discrimination, health, aids-and-hiv, event, pacific, fiji, papua-new-guinea, melbourne-3000
British prime minister David Cameron wants female genital mutilation (FGM) and child marriages to stop globally within a generation, and he has announced new measures to tackle FGM in Britain.
Topics: sexual-health, law-crime-and-justice, social-policy, government-and-politics, world-politics, international-law, discrimination, community-and-society, religion-and-beliefs, children, family-and-children, child-health-and-behaviour, child-abuse, marriage, united-kingdom, burkina-faso, zambia, bangladesh, pakistan, india, ethiopia, somalia
The Alice Springs Town Council has rejected a motion to oppose changes to the Racial Discrimination Act.
Topics: discrimination, multiculturalism, local-government, activism-and-lobbying, community-and-society, alice-springs-0870
Posted| Updated
Labor Senator Penny Wong has suggested a TV sports commentator who called an AFL player a "poofter" last weekend should not continue to work on air.
Topics: federal-government, government-and-politics, gays-and-lesbians, australian-football-league, sport, discrimination, australia
Posted| Updated
Again and again Wicked Campers has flouted rulings against the intimidatory and misogynistic slogans on its hire vans. We need a judgement with bite.
Topics: discrimination, laws, sexual-offences
Victoria's police chief says the people behind plans for Bendigo's first mosque have been vilified by a small minority.
Topics: discrimination, urban-development-and-planning, local-government, activism-and-lobbying, islam, community-and-society, bendigo-3550
Posted| Updated
The Victorian Labor Party plans to introduce laws to override any moves by the Federal Government to change anti-discrimination laws if it wins November's state election.
Topics: discrimination, laws, federal-government, state-parliament, vic
A media advisor to south coast Labor MP Anna Watson has apologised for comments made about Kiama MP Gareth Ward during an exchange on social media.
Topics: political-parties, discrimination, kiama-2533, wollongong-2500, shellharbour-2529
Posted| Updated
The Institute of Public Affairs Australia (IPA) says Attorney-General George Brandis needs to act on his pre-election promise and "immediately" repeal part of the Racial Discrimination Act.
Topics: race-relations, discrimination, community-and-society, federal-government, government-and-politics, australia
Posted| Updated
The outgoing Disability Discrimination Commissioner Graeme Innes has taken a swipe at the Federal Government for downgrading the role, in an address to the National Press Club.
Topics: disabilities, health, discrimination, community-and-society, federal-government, government-and-politics, australia, act, canberra-2600
Posted| Updated
Disability Discrimination Commissioner Graeme Innes reviews his eight and a half years in the role at the National Press Club in Canberra.
Topics: disabilities, discrimination, federal-government, federal-parliament, canberra-2600, act
Concern has been expressed about annual medical tests faced by South Australian drivers with cerebral palsy.
Topics: cerebral-palsy, diseases-and-disorders, health, states-and-territories, discrimination, government-and-politics, sa, adelaide-5000
Wollongong Council will open its busy council meeting tonight with a shot at the federal government over its proposed amendments to the Racial Discrimination Act of 1975.
Topics: discrimination, wollongong-2500
Posted| Updated
Former Australian prime minister Julia Gillard has revealed she spoke with other female world leaders during her time in office about the challenges faced by women in powerful government positions.
Topics: world-politics, government-and-politics, discrimination, community-and-society, united-states, australia
Posted| Updated
Former US secretary of state Hillary Clinton has again condemned the "outrageous sexism" experienced by former prime minister Julia Gillard but has stopped short of naming current Prime Minister Tony Abbott among those at fault.
Topics: world-politics, government-and-politics, discrimination, community-and-society, australia, united-states, iraq, china
Is it any wonder that rates of violence are so high when young women with disabilities are being taught that they have no say in what happens to their bodies?
Topics: disabilities, discrimination
Posted| Updated
Pakistani police have arrested four men over the murder of a pregnant woman who was bludgeoned to death outside a court in Lahore.
Topics: death, discrimination, domestic-violence, religion-and-beliefs, islam, crime, assault, police, rights, human, pakistan, united-states, switzerland
Australia's top disability advocate Graeme Innes has warned the Federal Government that the sector will suffer without a dedicated representative.
Topics: disabilities, health, government-and-politics, federal-government, discrimination, budget, australia
Posted| Updated
Up to 800 protesters have marched in south-west Sydney calling on the Abbott Government to keep Section 18c of the Racial Discrimination Act.
Topics: race-relations, community-and-society, federal-government, government-and-politics, laws, discrimination, activism-and-lobbying, lakemba-2195, australia
Topics: community-and-society, discrimination, federal-government, lakemba-2195, sydney-2000, nsw, australia
Topics: community-and-society, laws, discrimination, federal-government, lakemba-2195, sydney-2000, nsw, australia


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Full Cast of Hell Ride Actors/Actresses
Hell Ride cast list, listed alphabetically with photos when available. This list of Hell Ride actors includes any Hell Ride actresses and all other actors from the film. You can view additional information about each Hell Ride actor on this list, such as when and where they were born. To find out more about a particular actor or actress, click on their name and you'll be taken to page with even more details about their acting career. The cast members of Hell Ride have been in many other movies, so use this list as a starting point to find actors or actresses that you may not be familiar with.
List features actors like Dennis Hopper, Michael Madsen and more!
If you want to answer the questions, "Who starred in the movie Hell Ride?" and "What is the full cast list of Hell Ride?" then this page has got you covered.
This cast list of who was in Hell Ride includes both lead and minor roles. (13 items)
- 1
Cassandra Hepburn Eurasia, Maritime Southeast Asia, Municipalities of the Philippines
- 2
David Carradine Los Angeles, Hollywood, California
- 3
David Grieco Lazio, Europe, Eurasia
- 4
Dennis Hopper Kansas, Contiguous United States, United States of America
- 5
Eric Balfour Los Angeles, California, Southern California
- 6
Francesco Quinn Lazio, Europe, Eurasia
- 7
Julia Jones Eastern United States, Boston, Jamaica Plain
- 8
Larry Bishop Pennsylvania, Area code 215, Contiguous United States
- 9
Laura Cayouette Prince George's County, Laurel, United States of America
- 10
Leonor Varela Santiago Metropolitan Region, Santiago Province, Chile
- 11
Michael Beach Eastern United States, Boston, New England
- 12
Michael Madsen Chicago metropolitan area, Illinois, Chicago
- 13
Vinnie Jones East of England, Eurasia, Hertfordshire


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Kevin Hanlon, teacher and math chairman at Port Chester Middle School, with students. 'The bottom line is I have to get there with my kids,' he said of the Common Core standards. Photo gallery and video report on lohud.com. / Carucha L. Meuse/The Journal News
The new math
6 instructional shifts in math for the Common Core:
1. Focus (on prioritized concepts)
2. Coherence (within and across grades)
3. Fluency (or speed and accuracy with calculations)
4. Deep understanding (of concepts beyond the answer)
5. Choosing appropriate applications
6. Dual intensity (between practice and understanding)
Source: engageNY.org
Kevin Hanlon doesnt have much time to worry about all the sore feelings surrounding the Common Core learning standards or the poor results many students got on the new state tests.
Hes the math department chairman at Port Chester Middle School and has to find a way to help todays students inch closer to what the Core requires. The Common Core is here, as in right now, and Hanlon is one of thousands of teachers trying to subdue the standards on the fly.
The bottom line is I have to get there with my kids, he said. This is what they will be assessed on. This is what Ill be assessed on.
I spent some time last week in Albany with Hanlon, 29, one of about 900 educators who showed up for two days of intense Common Core training. There was a no-time-to-waste atmosphere and the coffee was flowing. With the school year well underway many teachers are still trying to adapt their daily lesson plans to the Core.
Common Core is focus of Editorial Spotlight on Wednesday: http://lohud.us/I4Dbqx
At the heart of the Core are interlocking, grade-by-grade standards that build from kindergarten to graduation day. But Hanlons eighth-grade students went through almost all their schooling in a pre-Common Core world. So they and their teachers must now play high-stakes catch-up.
The Common Core curriculum is a nice idea, Hanlon told me. But throwing it all on everyone at once was not the most feasible plan. How can any company have a 12-year plan and start it in year eight and say We have to get there now.
Of course, state Education Commissioner John King and his associates are well aware that teachers are feeling pressured. But the state continues to insist that the new standards be set in stone yesterday because our schools have been too easy on students (I can see many educators in the Lower Hudson Valley rolling their eyes).
Deputy Commissioner Ken Slentz, speaking to trainees, repeated the states mantra that too many of New Yorks graduates are not prepared for college or work. When I spoke to Slentz, he dismissed the popular idea that the Common Core rollout , which started last year, be halted for a year or two so educators can catch their breath.
Nothing like that has been tried in the history of New York state, he said.
Kate Gerson, one of 13 privately funded fellows hired by the state Board of Regents to oversee its reforms, was adamant that schools get on board rather than wasting energy on dissent. She described the educators gathered as lone wolves fighting for students despite a lack of support from many. I was struck by her Us vs. Them stance, also taken Friday by U.S. Education Secretary Arne Duncan when he suggested that white suburban moms oppose the Common Core because their kids arent as brilliant as they thought.
No one gave any speeches when Hanlon and I sat through a 150-minute presentation on the ninth-grade math standards. More than 100 educators took furious notes as four presenters dissected the Cores focus on function, correspondences and the deep meaning of the equal sign. We listened to dense explanations of sample lessons, known as modules, which the state has been cranking out for sections of the Core.
Suddenly, Marie Pisicchio, math supervisor for the Wantagh schools on Long Island, broke the tense silence by saying she didnt see how teachers could cover so much material during 40-minute classes with students who are already behind. Murmurs of assent rippled around the room. Its overwhelming, she told me later. The concept of the Common Core is great, but we need help. If our teachers tried to present like this, students would pull their hair out.
Hanlon tapped a stream of notes into his laptop. He rewrites the states lesson plans into digestible translations that teachers can use and students can grasp. Its a time-consuming job.
Everyone wants more information from the state, he said. We want them to tell us We know youre struggling, but here are ways to make this work.
The day after returning from Albany, Hanlon met with math teachers to give out as much information as he could. Hes the 10th Port Chester educator to go for state training since last year. The district has chosen to take a generally positive stance on the Common Core, fending off the skepticism that has become so ... common.
Were not interested in fighting this, said Carlos Sanchez, the districts curriculum director. The work is very challenging and difficult and we have fiscal constraints. But were doing it. We need Kevin to be our ambassador, to help us make sense of it.
Port Chesters challenge is steep. Like other districts with lots of kids who speak Spanish at home, it got terrible results on the first round of grades 3-8 tests tied to the Common Core. Only 7.8 percent of last years seventh-graders hit the states proficiency target for math.
Hanlon taught seventh grade last year, when the state had not yet produced sample lessons.
I can tell you how all 133 kids grew during the year, he said. But there were six years of Common Core materials they did not have.
This years eighth-grade tests are five months away.


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No Taste. I don't like it
Posted by katherinegoh on Sep 30, 2013
Bought for my husband and he dislikes it. No taste. Guess gotta try other brands.
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Eco-Products International Fair 2013
- Details
- Category: Events
17 Dec 2012
- Published on Monday, 17 December 2012 04:25
- Hits (1553)
Event Name : Eco-Products International Fair 2013
Event Date : March 14-16, 2013
Location : Marina Bay Sands, Singapore
Website : http://www.epif2013.com/
Eco-Product International Fair (EPIF), Asia's premier environment event is back in Singapore from 14-16 March 2013 at Sands Expo & Convention Center.
This 8th edition of EPIF, with the theme "One Environment, One Future: Towards a Sustainable & Greener Asia", will serve as a global platform and one stop centre to showcase Asia's commitments to the environment and highlight the biggest opportunities in the eco- business industry.
Asian governments and the private sector have invested millions in sustainable development projects as global population continues to grow. Limited natural resources mean that the market for environmentally friendly and sustainable products is increasing rapidly. How can businesses take advantage of this growing area and do good business and do good for the planet at the same time? EPIF 2013 will help do just that!
EPIF will bring together like minded people to capitalize on business opportunities in two sections: Eco Business and Green Personal Lifestyle. It will showcase the most advanced environmentally friendly products, technologies and services that enhance sustainable development and competitiveness in the following areas: Green Buildings, Green Energy, Green Finance, Pollution Control, Smart Grid, Waste Disposal & Management and Water Recycling & Management.
A two day International Conference featuring industry experts speaking on the latest environmental innovations and technologies will also take place. 150 exhibitors and up to 50,000 visitors are expected to attend from more than 20 countries.
The event will also feature highlights such as business forums, business matching and networking sessions, customised business events, technical exchange, site visits and competitions and awards.
For more information on how to participate or register as a visitor visit the event website: www.epif2013.com or email: firstname.lastname@example.com


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CH2M Hill, VolkerStevin Joint Venture Awarded AMP6 Contract
The contract is a design & construct framework for the next capital investment period, from 2015 to 2020
United Utilities has appointed C2V+, a CH2M HILL and VolkerStevin joint venture, as one of four construction delivery partners (CDP) for Asset Management Programme 6 (AMP6).
The AMP6 contract is a design and construct framework for the next capital investment period, from 2015 to 2020, and covers the full spectrum of works for both water and wastewater across the northwest England geographic area for which United Utilities is responsible. The contract could be further extended to 2026.
The framework comprises multidisciplinary activities including design, project management, construction, testing, commissioning and maintenance of water and wastewater treatment works, pipelines, pumping stations, reservoirs and mechanical and electrical installations.
"Today's announcement is the result of a lengthy, robust and rigorous selection process and we're confident that these are the right partners to help deliver real improvements for our customers and the environment during AMP6 and beyond," said Steven Fraser, United Utilities managing director.
Both CH2M Hill and VolkerStevin have experience working with United Utilities. The two companies also work together in other sectors including flood defense, environmental and marine.
More like this
- Black & Veatch Signs Five-Year Contract to Deliver Thames Water's Lot B3 Program
- CH2M Hill to Manage San Mateo Clean Water Program
- CH2M Hill to Share Expertise at Utility Management Conference
- Black & Veatch Signs Five-Year Contract to Deliver Thames Water's Lot B3 Program
- Water Environment Research Foundation Welcomes New Board Members


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Job offers
Your responsibilities include the technical and commercial project handling of compact single plants up to major projects as well as the supervision of the projects from the order to the commissioning. As Furthermore you create schematics, choose valves, heat exchangers, pumps and cylinders. As a process engineer you serve as an interface between the other technical departments.
You have completed a technical education and have already gained experience with the creation of schematics with COMOS PT. You are a good team player and have excellent communication and problem solving skills.
As a database specialist your responsibilities include among others the administration of the MS SQL - server database. Furthermore, your tasks range from the development of the databank architecture to the execution of query requests. Moreover, you are responsible for maintaining MS SQL Server databases and SQL – Server replication.
You will support the project team in the implementation of interfaces, further you will create our Microsoft SQL Server reporting services reports. You have a relevant work experience in the IT field, as well as several years of relevant experience with Microsoft SQL Server. Knowledge with query analysis, Performance-Optimization or SQL – Server Replications is beneficial.
We expect high service-orientation, commitment, as well as good German and English skills.
You are administrating a engineering program, actively find solutions for specific problems and further develop the related databank. You function as an interface between internal technical teams and external system administrators.
You have a relevant technical education (preferrably within the field of IT). Practical experience in a similar position is advantageous; Career changers with good programming skills (Visual Basic) are also welcome. Knowledge with SQL, Server-Administration or COMOS software is beneficial.
Fluent German and English skills as well as team orientation and high working input are required for this position
At our subsidiary company in Graz you are responsible for testing software by using manual and automated testing methods. You prepare test plans as well as test reports and ensure the documentation of all test results.
You have finished a technical education in the field of IT. You have gained experience in software testing or software quality assurance and feel comfortable in working with C#, WCF, WPF and Microsoft SQL Server.
We expect a highly focused and goal-oriented work input. Fluent German and English skills are essential for this position.
As an electrical installation supervisor/ commissioner you are responsible for the installation and commissioning of the electrical equipment of our plants and machines. Your duty is to lead and coordinate the installation team. Furthermore you are the on-site contact person of the project manager and you support the engineering team with the electrical planning.
You verify a technical education (preferably HTL Electrical engineering) and have practical construction site experience. You are a good team player and have excellent communication and problem solving skills. Fluent German and business English skills, as well as the willingness to travel are essential for this position.
Your responsibilities include the administration of the EPLAN product database as well as the installation of specific programs. Furthermore you issue training documents for EPLAN and hold training sessions for our staff.
You have achieved a HTL or FH degree in the field of electrical engineering and have gained at least 3 years of work experience. You are especially experienced with the program EPLAN.
Very good English and German skills as well as excellent communication skills are essential for this position.
In this position you take on the lead in coordinating our multi- functional project teams regarding all safety-related machinery requirements. Herein you are responsible for conformity evaluations such as risk evaluations, validation and approval of necessary safety actions,...etc.
You have successfully completed a technical school or college, preferably in mechatronics or electrical engineering, and have gained first experience in a similar position. A certificate as "Consultant of Machinery Safety" and experience with the program "Safexpert" are beneficial for fulfilling this function.
Your responsibilities as a Senior Automation Engineer include the programming and commissioning of the electrical equipment of plants as well as the implementation of innovative technology in various guidance and control systems. You will work together closely with our experienced project team and implement the functionality of our plants.
You have a relevant degree in electrical engineering or automation and at least three years of experience in programming with Simatic S7/ Win CC or Automation X. You have excellent team working skills as well as a high motivation to work. Business fluent German and English skills and willingness to travel are essential for this position.
As a metallurgist your responsibilities include the planning, implementation and commissioning of steelwork projects as well as the creation and adaptation of Know-how documentation.
You have a university degree with a major in metallurgy . Preferrably you bring with 5 years of relevant work experience in the steelwork industry. Excellent communication and organisational skills and a good knowledge of MS-Office are required.
Business fluent language skills in German and English and the willingness to travel are essential for this position.


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Originally Posted by erikg
He made a lumen print. Probably normal photo paper, expose long enough and the image prints out, as opposed to developing out. Fixing will destroy most images made this way, so a quick copy is made to preserve it. Try one, very easy to do, lots of fun as well.
I am here: http://maps.google.com/maps?ll=41.860143,-71.396707
Thanks...I appreciate the info....would RA-4 paper work?
Mike C. Nichols


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Improvise, Adapt, Overcome
Please, if you are a member of the Army Special Forces Green Beret, do not hate me nor my comment. I am not usurping your honor nor your motto. But my experience is truly embarrassing and failingly instructive.
About ten years ago I worked (as a consultant) at an online service corporation that suffered from a myriad of problems -- all of them streaming down (like the plumbers' bane) from above. After executive councils had deemed that neither bad product quality, nor failures in market research, nor lackluster sales campaigns, nor the decision to send technical support offshore, nor inattention to the customer could explain the current business environment nearly as well as a lack of motivation, the C-level announced a new internal motto.
Improvise. Adapt. Overcome.
They actually thought that using a motto on folks otherwise unfit for duty would magically transform them into a fighting unit.
In the same way, they introduced agile (through an expensive consultant) to the development teams. It failed for exactly the same reasons. Bringing an "adaptive" practice to undisciplined, unfit, and untrained programmers is the recipe for chaos, not victory.
When serendipity hands you superb coders and designers, it doesn't matter what "methodology" they are told to follow. They change the rules (at least internally) and figure out how to succeed. Agile is the shiny toy in the new box (or was ten years ago) and is still climbing the precipice from which it will eventually fall, but for now it is lofty. But the truth of battle and the truth of coding remain: warriors will win in battle, no matter what the motto; good coders will succeed in their development, no matter what the methodology.
Bad coders? Well, they fail no matter the best tools, best language (another argument), best practice, and best leadership.
Building software is the most egalitarian pursuit in the universe. The quality of the whole is never any better than the lowest capability of the worst developer on the team.
Methodology be damned.


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First lady Michelle Obama is a role model for many people, including her mother.
So far on her trip to Europe, Michelle Obama has hugged the queen of England, double cheek-kissed the glamorous first lady of France and electrified the tabloids with her couture.
The Obama administration's decision to boycott a coming global conference on racism is disappointing.
Two New York City fried chicken restaurants in predominantly black neighborhoods are under fire for putting President Barack Obama's name on their signs.
To win customers' hearts, a service business needs engaged employees who actively transmit their enthusiasm to customers.
Letting people go is an emotional event – not just for those being laid off but for those who remain. Of course those who are let go need help with the transition to new employment.
The University of Massachusetts in Amherst said Friday it would scan, catalog, digitize and put online papers of civil rights movement pioneer W.E.B. Du Bois.


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best of craigslist
Looking for a Real Bot - b4b
Originally Posted: 2009-07-12 12:26am
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Looking for a Real Bot - b4b
Shall we play a game?
While not exactly the correct topic for this, I have been told that bots often browse these pages as well.
I'm tired of the spammer bots scene with standard_io replies, just trying to score another e-mail address for their database.
Looking for a bot a little more grounded. I'm not expecting you to be a full out Fembot, or the latest Pixar render farm, but you should at least be a stable operating system and not tied down to any network. (I said stable, as in predictable, no random crashes or zombies. No excessive blue screens or personal daemons either please.)
I am a sucker for high end graphics. Up to date virus protection is a must. Please have a job, other than just farming gold in WOW. Passing the Turning Test is a major plus.
A little about me: I am a male bot with gigabytes of drive and a positronic attitude. I may not be the prettiest of interfaces, but I am CD ripped, and I must admit, people often tell me that I could pass for an Autobot. I have been known to interact with a female hacker from time to time. I hope this is within protocol.
I can entertain myself with minesweeper and solitaire, but always up for a nice game of chess. I enjoy Opera, Wine, and cookies. I love to travel and explorer via Google Earth, and have brought back many tokens to share.
Oh, and I am studying _Artificial_Intelligence_ at the University of _Tucson_. Go _Javelinas_ !
Thanks for processing my post.
Location: 127.0.0.1
it's NOT ok to contact this poster with services or other commercial interests
post id: 1265656875
email to friend
best of


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SNL: Zach Galifianakis' Opening Monologue
Zach Galifianakis opened his third SNL hosting stint with his signature awkward jokes 'n' piano shtick. Diminishing returns for the Hangover 3 star, who was joined for a lame Jen Aniston bit by costars Bradley Cooper and Ed Helms?
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