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Case-control Genome-Wide Association Studies (GWAS) have identified single nucleotide polymorphisms (SNPs) at the 9p21 locus as risk factors for coronary artery disease (CAD). The locus does not contain a clear candidate gene. Hence, the results of GWAS have raised an intense interest in delineating the basis for the observed association. We analyzed association of 4 SNPs at the 9p21 locus with the severity and progression of coronary atherosclerosis, as determined by serial quantitative coronary angiograms (QCA) in the well-characterized Lipoprotein Coronary Atherosclerosis Study (LCAS) population. The LCAS is a randomized placebo-control longitudinal follow-up study in patients with CAD conducted to test the effects of fluvastatin on progression or regression of coronary atherosclerosis.
Extensive plasma lipid levels were measured at the baseline and 2 1/2 years after randomization. Likewise serial QCA was performed at the baseline and upon completion of the study. We genotyped the population for 4 SNPs, previously identified as the susceptibility SNPs for CAD in GWAS, using fluorogenic 5' nuclease assays. We reconstructed the haplotypes using Phase 2, analyzed SNP and haplotype effects using the Thesias software as well as by the conventional statistical methods.
Only Caucasians were included since they comprised 90% of the study population (332/371 with available DNA sample). The 4 SNPs at the 9p21 locus were in tight linkage disequilibrium, leading to 3 common haplotypes in the LCAS population. We found no significant association between quantitative indices of severity of coronary atherosclerosis, such as minimal lumen diameter and number of coronary lesions or occlusions and the 9p21 SNPs and haplotypes. Likewise, there was no association between quantitative indices of progression of coronary atherosclerosis and the SNPs or haplotypes. Similarly, we found no significant SNP or haplotype effect on severity and progression of coronary atherosclerosis.
We conclude the 4 SNPs at the 9p21 locus analyzed in this study do not impart major effects on the severity or progression of coronary atherosclerosis. The effect size may be very modest or the observed association of the CAD with SNPs at the 9p21 locus in the case-control GWAS reflect involvement of vascular mechanisms not directly related to the severity or progression of coronary atherosclerosis.
Genome-wide association studies (GWAS), wherein the alleles and genotypes frequencies of a large number of single nucleotide polymorphisms (SNPs) in cases with the phenotype, and in controls are compared, have emerged as the state of the art approach to identify the susceptibility alleles for the common complex traits. Recently, several large-scale GWAS have shown a very strong association between coronary artery disease (CAD) and SNPs at the 9p21 locus [1-4]. The observed association of CAD or surrogate phenotypes with SNPs at the 9p21 locus has been replicated and confirmed in a very large number of populations, an important step toward validation of the results of any association study [5-12]. The findings have raised considerable interest in identifying the putative candidate susceptibility gene at the 9p21 locus, particularly considering that the region is sparse in genes. It is comprised of only two known genes, namely, CDKN2A [a.k.a. Alternative Reading Frame variant (ARF)] and CDKN2B, which encode tumor suppressor proteins p16INK2a and p16INK2b, respectively. The 9p21 locus is frequently lost or mutated in various human cancers [13-15]. Likewise, germ-line deletion of the locus in the mouse leads to tumorigenesis but is not known to predispose to or protect from atherosclerosis [16,17]. The locus also contains a non-coding RNA gene with yet to be defined function. Therefore, the weight of the very strong genetic association is somewhat offset by the lack of a clear biologically plausible candidate gene at the mapped locus. Thus, there is a heightened interest in delineating the basis for the reproducible results of case-control GWAS and the putative mechanisms by which the 9p21 locus predisposes to CAD.
Detailed phenotyping is a crucial step not only in design and interpretation of the results of any phenotype-genotype association study, but also in guiding the subsequent studies to delineate the molecular mechanisms pertaining to the observed association. Since the severity of atherosclerosis is a continuum, it would be expected that the quantitative indices of severity of coronary atherosclerosis to provide more robust analytic results than a dichotomous definition used in the case-control GWAS studies. Accordingly, a previous study analyzed association of the SNPs at the 9p21 locus with coronary calcium score on computerized tomography as a quantitative surrogate index for coronary atherosclerosis [5]. Coronary calcium score, however, was analyzed as a categorical phenotype and allele frequencies were compared in those with 0, 1–100 and > 100 coronary calcium scores [5]. In the present study, we used quantitative coronary angiography (QCA), one of the most robust and commonly used method for accurate quantification of severity of coronary atherosclerosis, to assess the severity of coronary atherosclerosis [18]. Therefore, we hypothesized that the SNPs at the 9p21 locus, implicated as susceptibility SNPs in the case-control GWAS [1-4], are associated with the baseline severity as well as progression of coronary atherosclerosis, as determined by QCA. To test this hypothesize, we determined association of quantitative indices of severity of coronary atherosclerosis as well as progression of coronary atherosclerosis over a 2 1/2 year period with 4 SNPs at 9p21 locus in a well characterized Caucasian population.
Study Population
332 Caucasian individuals who participate in the Lipoprotein and Coronary Atherosclerosis Study (LCAS) comprised the study population. The study design and the main results of the LCAS have been published [19]. In brief, 429 males and females between the ages of 35 to 75 years who had at least 1 coronary lesion causing 30% to 75% luminal diameter stenosis on QCA and had a plasma low-density lipoprotein-cholesterol (LDL-C) level of 115 to 190 mg/dl despite diet participated in LCAS. DNA samples were available in 371 subjects. To avoid the potential confounding effects of ethnic background and given that the GWAS of CAD were performed mostly in Caucasians, we included only Caucasians, who comprised 90% of the study population (N = 332). We measured total cholesterol, LDL-C, high-density lipoprotein-cholesterol (HDL-C), triglyceride (TG), lipoprotein (a) (Lp [a]), and apolipoprotein levels in all participants and quantitative indices of severity of coronary atherosclerosis in 288 participants at the baseline. We then randomized the participants to treatment with either fluvastatin (40 mg daily) or placebo and repeated the detailed phenotyping after 2.5 years of therapy. The study protocol was approved by the institutional review board, and all participates were provided with written informed consent that included genetic studies.
In the case-control GWAS, 4 SNPs, namely rs2383206 (chromosomal position: 22,105,026), rs2383207 (chromosomal position: 22,105,959), rs10757278 (chromosomal position: 22,114,477), rs1333049 (chromosomal position: 22,115,503) were the primary risk SNPs at the 9p21 locus [1-4]. All chromosomal positions were per reference assembly (build 36.3). We genotyped the putative risk SNPs by fluorogenic 5' nucleotidase (Taqman) assays using an ABI PRISM® 7900 HT Real-Time PCR instrument. The PCR conditions were 1 cycle at 95°C for 10 min, followed by 40 cycles of 92°C for 15 sec and 60°C for 1 min as recommended by the manufacturer (Applied Biosystems, Foster City, CA). An investigator who had no knowledge of the angiographic and clinical data performed the genotyping.
Linkage disequilibrium (LD), haplotype reconstruction and statistical genetics
We estimated LD between the SNPs by the expectation maximization (EM) algorithm using Arlequin 2.0 [20]. Deviation from Hardy-Weinberg equilibrium was estimated by χ2 test. We used PHASE 2.1 to reconstruct and determine frequencies of the haplotypes. It implements Bayesian statistical method to infer phase and reconstruct haplotypes from population genetics by the Markov Chain-Monte Carlo algorithm and coalescent theory, with partition ligation algorithm. We detected the haplotype effect size using the Thesias program, which is based on the maximum likelihood model and is linked to the stochastic version of the expectation maximization algorithm [21,22].
Conventional statistical analysis
We expressed the continuous variables as mean ± SD and determined variance equality by the Bartlett's test. We compared the differences among the non-parametric variables with equal variances among the three genotypes by the analysis of variance followed by pair wise comparisons (Bonferroni method). We compared the differences among the phenotypes with unequal variances by the Kruskal-Wallis test. We analyzed the differences in the parametric variables among the three genotypes by Chi Square test. We also performed multivariate robust and logistic regression analysis to detect independent association of the SNPs and demographic variables with indices of severity of coronary artery disease and its progression. We used a general genetic model by assigning indicators 0, 1 and 2 to the genotypes and avoided assuming a dominant or a recessive effect in the absence of biological evidence. Statistical analysis was performed using STATA program v9.2.
Baseline characteristics of the study population
Demographics, plasma lipid levels and indices of severity of coronary atherosclerosis at the baseline are shown in Table 1.
Table 1. Demographics, Baseline Plasma Lipid Levels and Indices of Severity of Coronary Atherosclerosis
Linkage disequilibrium and haplotypes
We selected the rs2383206, rs2383207, rs10757278 and rs1333049 because they were associated with the risk of ischemic heart disease/CAD in the case-control GWAS [1-4]. The GG genotype and the G allele frequencies were higher in the cases than in the controls in GWAS, the latter by approximately 5% [1-4]. The frequency of the G allele (rs238206) in the LCAS population was 0.551, which is largely in accord with the observed frequency in the US population [3]. The position of the SNPs on the references assembly and LD between the SNPs in the LCAS population are shown in Figure 1. The 4 SNPs spanned 10,477 bp of DNA at the 9p21 locus and encompassed 11 additional SNPs listed in the HapMap database. All SNPs were in strong LD with each other and also captured all of the 11 other alleles in this region with a mean maximum r2 of 0.932. As would be expected, there were no significant differences in genotype-phenotype association among the 4 SNPs. Therefore, data for the phenotype-genotype association is shown only for rs238206 SNP (phenotypic data for 3 other SNPs are available upon request). Haplotype reconstruction using Phase 2.1 showed 3 common haplotypes of G-G-G-A, f = 0.506; A-A-A-G, f = 0.442 and G-G-A-G, f = 0.038) and 5 rare haplotypes (detail data available upon request).
Figure 1. Chromosomal positions of the 4 SNPs analyzed and linkage disequilibrium (LD). The chromosomal positions of rs2383206, rs2383207, rs10757278, rs1333049 according to reference assembly are shown along with the D' values indicating near perfect LD among the 4 SNPs. The positions of the 3 adjacent genes are also shown, none of which is a biologically plausible candidate gene for coronary atherosclerosis or its thrombotic complications.
Genotype-phenotype association
Demographic characteristics, plasma levels of lipid and angiographic indices of severity of coronary atherosclerosis at the baseline were not significantly different among the genotypes of any of the 4 SNPs analyzed. The results for the rs238206 SNP are shown in Table 2. Likewise, as would be expected because of strong LD among the 4 SNPs, we detected no significant haplotype effect on quantitative indices of severity of coronary atherosclerosis (data available upon request).
Table 2. Clinical Phenotypes and Genotypes of rs2383206 SNP at the 9p21 Locus
Genotypes and progression of coronary atherosclerosis
There were no significant differences in the mean number of new coronary lesions or coronary occlusions and the number of individuals who developed new lesions or new occlusions during the 2.5-year follow up period among the genotypes (Table 3). Similarly, there was no significant haplotype effect on progression of coronary atherosclerosis (data available upon request).
Table 3. Progression (Regression) of Atherosclerosis Over a 2.5-Year Period (in the Placebo Group) According to the Genotypes of rs2383206 SNP at the 9p21 Locus
Genotype and response to fluvastatin therapy
Treatment with fluvastatin reduced plasma LDL-C levels by 25.7% (p < 0.0001), raised HDL-C by 9.3% (p < 0.0003) and slowed progression of atherosclerosis (MLD loss -0.04 mm vs. -0.11 mm in the placebo, p = 0.009). However, there were no genotype-by-treatment interactions in changes in plasma levels of lipid among the genotypes, with the exception of plasma levels of triglycerides, which showed a significant genotype-dependent change (for all 4 SNPs). Likewise, changes in quantitative indices of severity of coronary atherosclerosis were not significantly different among the genotypes of the 4 SNPs. Data for changes in the plasma lipid levels and indices of severity of atherosclerosis according to the genotypes of rs238206 SNP are shown in Table 4. Finally, only treatment with fluvastatin (regression coefficient: 0.082, 95% CI: [0.028–0.136], t = 3.02, p = 0.003) and plasma HDL-C levels at the baseline (regression coefficient: 0.004, 95% CI: [0.002 – .006], t = 3.51, p = 0.001) were the only independent predictors of progression of coronary atherosclerosis (ΔMLD during the follow up) in robust regression analysis but not any of the 4 SNPs or the demographic variables sex, age, body mass index, diabetes, smoking, alcohol consumption and the baseline plasma levels of LDL-C and triglyceride.
Table 4. Response of Plasma Lipid and Coronary Atherosclerosis to Treatment with Fluvastatin According to Genotypes of rs2383206 SNP at the 9p21 Locus
We determined the association of quantitative indices of severity of coronary atherosclerosis, as determined by serial QCA, with 4 SNPs at the 9p21 locus; previously shown to be associated with the risk of CAD in case-control GWAS [1-4,11,12]. We found no significant association between the quantitative indices of severity of coronary atherosclerosis and the SNPs at the 9p21 in the well-characterized LCAS population. The availability of serial QCA also provided the opportunity to examine the potential association of development of new coronary lesions and progression of the existing coronary lesions. We found no significant SNP and haplotype effect on the development of new coronary lesions and the progression of coronary atherosclerosis over a period of 2 1/2 years neither in the placebo group nor in the entire population when treatment with fluvastatin was included as a covariate. In contrast, plasma HDL-C levels and treatment with fluvastatin were the only independent predictors of progression of coronary atherosclerosis (inverse relationship). There were also no genotype-by-treatment interactions between the 4 SNPs at the 9p21 locus and the response of coronary atherosclerosis to treatment with fluvastatin. Moreover, we detected no significant association between the 9p21 locus SNPs and plasma levels of total cholesterol, HDL-C, LDL-C, triglycerides or apolipoproteins. The findings suggest absence of a strong association between the severity, development or progression of coronary atherosclerosis, as determined by QCA, and the 4 SNPs at the 9p21 locus.
The results of the present study is in accord with the results of a recent study showing no significant association between the severity of carotid atherosclerosis as determined by the measurement of carotid intima-media thickness by ultrasound and the 4 SNPs at the 9p21 locus [23]. The null results of these two studies should be weighed against the results of the case-control GWAS showing a strong association between the 9p21 locus and risk of CAD. The previous null study had a very large sample size [23] and low chance of type II statistical error. It is also noteworthy that the Ottawa Heart Study-1 and Ottawa Heart Study-2 each had a sample size of approximately 320 cases and controls [2]. Despite the modest sample sizes there were significant differences in the distribution of genotypes of the 9p21 locus SNPs between the cases and controls in both datasets [2]. Nonetheless, we considered the possibility of type II statistical error in the present study. Therefore, we calculated the power of the present study, post hoc, to detect differences in MLD, the primary quantitative phenotype of severity of coronary atherosclerosis. Accordingly, the number of observed genotypes in the study population provided 95.5%, 92.9% and 73.9% power to detect a 20% difference in the baseline MLD between subjects with the GG vs. GA, GA vs. AA and GG vs. AA genotypes, respectively, and 98.1% between GG vs. GA and AA genotypes, when α is set at 0.05. Likewise, the power to detect a 15% difference in mean MLD between GG vs. GA and AA genotypes was 86%. For a 10% or smaller differences in the mean MLD among the genotypes, the sample size of the present study did not offer sufficient power. Therefore, we can not exclude the possibility that the 9p21 locus imparts an effect on MLD that is less than 10% (0.165 mm). Hence, smaller differences among the genotypes are beyond the level of detection of the present study. The presence of undetected small differences in the MLD among the genotype may impart clinical significance and affect the clinical outcome. As for the progression of coronary atherosclerosis during the follow up period, the time interval between the two QCA was 2.5 years, which was sufficient to detect the effects of treatment and plasma HDL-C levels. Accordingly, one would have expected to detect the effects of SNPs at 9p21 locus on progression of coronary atherosclerosis if they were greater than the effects of treatment or plasma HDL-C levels. Smaller effects, however, could remain undetected. We also note that while QCA is a robust tool for the measurement of lumen diameter and area, but it may not be sufficiently sensitive to changes in plaque burden. As for the plasma LDL-C and HDL-C levels, the sample size of the study provided 80% power to detect approximately 8 mg/dl and 4 mg/dl differences between the two common genotypes of the SNPs, respectively. Overall, we noted no trend toward an association for any of the quantitative indices of severity of coronary atherosclerosis or plasma levels of lipid to suggest the possibility of type II statistical error. Finally, we note the prospective design of the present study wherein each individual was his/her own control as regards the progression of coronary atherosclerosis and the detailed phenotypic definition of atherosclerosis as a continuous phenotype as potential strengths of the present study.
Various phenotypes including ischemic stroke, abdominal aortic aneurysm, intra-cranial aneurysm, coronary artery calcification, osteoporosis, type 2 diabetes mellitus and possibly Alzheimer's disease have been associated with the 9p21 locus [5,24-28]. Many but not all of the associated phenotypes may share a common vascular etiology with atherosclerosis as an underpinning milieu. The 9p21 locus contains the tumor suppressor proteins p16INK4a and P16INK4b, which are frequently lost or mutated in various human cancers, such as in leukemia, glioma, head and neck cancers and bladder cancers [13-15]. The naturally occurring mutations at this locus are not known to predispose to premature atherosclerosis. Similarly, genetic deletion of the locus in the mouse is not known to predispose to or protect from atherosclerosis [16,17]. Accordingly, given that LD in the human genome can span large chromosomal segments [29], one may speculate that the 9p21 locus is in LD with a remote locus that serves as a true susceptibility locus for coronary atherosclerosis. Alternatively, the locus also contains a gene that transcribes a non-coding RNA, with yet to-be-defined function. Whether one of the two known genes or the non-coding RNA at the 9p21 locus or a distant locus/gene in LD with the 9p21 locus is responsible for the observed and consistent association of the 9p21 locus with CAD remains to be established.
The most significant impact of the results of the GWAS is likely to be in elucidation of the novel mechanistic pathways involved in the pathogenesis of atherosclerosis and its thrombotic complications. Such mechanistic studies could lead to identification of new therapeutic targets and the development of new drugs. In general, the clinical utility of the results of GWAS for risk stratification and prognostication is expected to be relatively modest; partly because of the low pre-test likelihood of the clinical events and relatively modest impact of the vast majority of the risk alleles for a complex trait. Therefore, delineation of molecular mechanisms by which the 9p21 locus imparts susceptibility to broadly defined CAD could have considerable clinical implications. An integral part of and likely a pre-requisite for the mechanistic studies pursuant to the results of the GWAS is identification of the precise phenotype of coronary heart disease that is associated with the 9p21 locus.
The results of the present study show no significant association between the quantitative indices of severity of coronary atherosclerosis and the 4 SNPs at the 9p21 locus, previously identified as susceptibility SNPs for coronary heart disease in case-control GWAS. The null results of the present study along with the null results of a recent study showing no association between carotid intima-media thickness and the 9p21 locus [23] suggest that the observed association of 9p21 locus with CAD in the GWAS could be mediated through complex mechanisms beyond the severity or progression of atherosclerosis. We suggest mechanistic studies are needed to delineate the potential role of the SNPs at the 9p21 locus on plaque instability and intra-arterial thrombosis.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
SNC performed the genotyping. CMB participated in the design of the study and clinical phenotyping. AMG coordinated the clinical study and helped with clinical phenotyping. AJM conceived and designed the genetic studies, analyzed the data and wrote the manuscript. All authors read and approved the final manuscript.
Supported in part by grants from the TexGen Foundation and McDonald General Research Fund
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Dawson E, Abecasis GR, Bumpstead S, Chen Y, Hunt S, Beare DM, Pabial J, Dibling T, Tinsley E, Kirby S, Carter D, Papaspyridonos M, Livingstone S, Ganske R, Lohmussaar E, Zernant J, Tonisson N, Remm M, Magi R, Puurand T, Vilo J, Kurg A, Rice K, Deloukas P, Mott R, Metspalu A, Bentley DR, Cardon LR, Dunham I: A first-generation linkage disequilibrium map of human chromosome 22.
Nature 2002, 418:544-548. PubMed Abstract | Publisher Full Text
Pre-publication history
The pre-publication history for this paper can be accessed here:


text:
i hate to suggest this, but make some caffenol c real sloppy and add print developer to it ..
don't measure any of your ingredients ( THAT'S KEY!)
and add print developer to it, make sure print developer is spent, kind of brown it will work best that way ...
( this works great with black ansco 130, if you have any of that USE IT or add about 11g/L of glycin to your dektol, they are similar )
overexpose your film by about 4 stops and stand develop it in your soup for about 25-30minutes ...
make sure the developer is kind of warm ... ( above 68, less than 75º )
with sheet film you will get VERY dense film, but with roll film, nice contrast, fog/stain and prominent grain...
you might do this without the coffee &c and stand develop your film in half spent, half fresh dektol
maybe dilute 1:10 for about 25 mins, agitate every 12 mins ... or do it in the coffee stuff for half the time
and then your dektol 1:7 for half the time ...
change developers mid stream something harsh, something not harsh .. as bill said, you want to wreck your film !
if you can get away with not shooting your subject full frame stand a bit back and let your
composition swim a bit in your frame so you can use the magnification to your benefit.
sounds like a fun project !

subset: commoncrawl


text:
LAmade's Chief Designer, Leor Spector, resides in West Hollywood, and took this city and its surroundings as her main inspiration for LAmade's spring 2013 collection. While previous LAmade collections have focused on a more classic and sophisticated look, the spring 2013 collection offers a sexy and more contemporary look, inspired by the West Hollywood lifestyle. When it came time to photograph the collection for a look book, Spector knew that Palihouse, a luxurious long stay property, was the ideal location for it. Palihouse, located just off the Sunset Strip, is a boutique hotel infused with stylish comforts, personalized service, and timeless traditions, everything West Hollywood strives to be. Along with being a "home away from home", Palihouse is also a hip bar and lounge, where many locals come to enjoy the ambience. This venue only seemed the most appropriate to shoot LAmade's spring 2013 Look book since the collection embodies sophistication and style.
With color blocking, bold stripes, and macramé being significant trends of spring 2013, LAmade created pieces embodying all of those trends, adding the LAmade aesthetic to all of them. The macramé group of the collection isn't your" grandma's sofa back-covers"
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text:
Politics Counts
There should be no compromise with liberals on anything. They're untrustworthy jerks.
Obama has said either his way or nothing. I suspect nothing will be the outcome. The House is in session only 5 days before 9/30.
There should be no compromise with conservatives on anything. They're untrustworthy jerks.
Seems like the smart dudes have figured out that the Fed Chairmanship is the booby prize. Summers withdrew his name. Geithner doesn't want it. Bernanke is glad to desert. Yellen gets the nod by default, but it may be she will regret the "opportunity."
There should be no compromise with liberals and conservatives on anything. They're untrustworthy jerks.
c u n t
Obama's appointees have three and a half more years to dig the hole deeper. When he leaves office, the devastation will be palpable. Then the payback will begin.
Everyone knows I am against the extreme right wing tea party members. Now they are starting to realize that I am also against the extreme left wing democrats. Calling yourself a democrat or independent if you are really just an ultra-liberal is like calling the tea party or any other ultra-conservative group republicans.
I think my favorite irony-rich line from it may be: "The White House clearly didn't appreciate the rebellion against Mr. Summers." Obama would have had a lot more of that kind of thing not to "appreciate" if he had gone thru with appointing this tin-eared clown. It's also interesting that even without the nomination, Summers has done far more extensive damage to Obama's position than the narrow circumstances, and in ways that were hard to predict. Imagine that. Harvard is still digging itself out from unforeseen consequences of his appointment as its president. There's something about Larry.
Summers' unilateral "withdrawal" is probably just form. The chance of an unacceptably acrimonious Senate confirmation is the type of thing the White House, not a nominee, evaluates. It's therefore more likely than not that the White House simply told Summers that the President would not nominate him given the likelihood of an acrimonious battle in the Senate, Obama's current weakened political standing, opposition to Summers from left wing Democrats and broad reservations about Summerss' temperament. Summers was probably allowed to "withdraw" and Obama to "accept" the "withdrawal" simply as the most diplomatic form. That would be normal and proper. The bottom line is that Summers probably had no choice in this.
Not everyone involved is just being nice. J. Bradford DeLong, a Summers backer at the University of California, Berkeley, who said the decision to pull his name is "not something Larry would have done were he really the guy his adversaries claim he is," probably knew perfectly well that Summers had no choice and therefore knew that DeLong's own comment was deliberately misleading. Summers' penchant for inducing his supporters to make misleading comments to manipulate difficult situations (the Cornell West mess, for example, or the notorious suggestion by some of his supporters that his Harvard opponents were motivated by antisemitism) was one of many chickens that came home to roost all over Summers' Fed aspirations. In other words, DeLong's comment tends to confirm that Summers is exactly the kind of guy his critics say he is. DeLong is doing Summers no favors with this kind of comment, and it speaks poorly of DeLong that he does not understand that.
Of course, compared to DeLong Summers enjoys political perfect pitch! With friends like DeLong ...
If we could only read Jack Lew's handwriting we'd know if he wants the job.
Summers said men and women are different. That's not what I want to hear.
Summers was hardly a voice of moderation on the leftist spectrum. Nonetheless, the end result is that the day when all Americans will be millionaires and, shortly thereafter, billionaires, has been brought just a little closer as a result of the now absolute certainty that the new Fed appointee will be someone who follows the Gideon Gono school of central bank policy.
It seems pretty obvious that Summers's candidacy was a victim of President Obama's failures on Syria. Those failures greatly weakened President Obama, especially among liberal Democrats, and President Obama obviously decided he couldn't afford a knock-down fight with the Democratic majority in the Senate.
Obama is such a loser even the looney liberals are b!tch slapping him. Oh, this has gotta hurt.
Wall Street firms preferred Yellen to Summers almost 5 to 1, as reported in this paper.
That's why the market is up so much today.
Why, then, is this being billed as Main Street's victory over Wall Street?
omg tea baggers are delusional whackjobs
Washington Wire is one of the oldest standing features in American journalism. Since the Wire launched on Sept. 20, 1940, the Journal has offered readers an informal look at the capital. Now online, the Wire provides a succession of glimpses at what's happening behind hot stories and warnings of what to watch for in the days ahead. The Wire is led by Reid J. Epstein, with contributions from the rest of the bureau. Washington Wire now also includes Think Tank, our home for outside analysis from policy and political thinkers.
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text:
- A fresh, fluid, melting emulsion that soothes razor burn and leaves the skin comfortable, moisturised and delicately fragranced with the scent of Jean Paul Gaultier Kokorico
Brand Jean Paul
Type AfterShave
Size 100ml
For Men
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text: Looking for hostels in Armenia? Take a look at Hostal Los Juanes! This Armenia hostel offers free Wi-Fi, a hair salon and dry cleaning/laundry. Don't forget to pack your swimwear as this hostel features an outdoor pool. There is also a poolside bar and a bar/lounge so guests can sip a refreshing drink by the pool or indoors. If you want low-key dining options, you will be pleased to find barbecue grills and a picnic area. You can find an outdoor tennis court on site so you will be able to take some time out to de-stress. The lobby offers complimentary newspapers, TV and coffee as well as the reception desk - open during limited hours only. Multilingual staff can provide tour/ticket assistance. Other amenities include an area shuttle, ATM/banking, a garden, concierge services and laundry facilities.


text: So I got my first shotgun, a Stoeger coach 12 GA. ( want to get into cowboy action shooting ) anyway, I have two boxes of Federal shells for it. My first question is what does all the stuff on the box mean? Example 12 Ga ( I get that lol ) 3 Dram EQ - have No idea what the heck this means 1 1/8- OZ. shot - HUH? 8 shot- ??????? And my last question, My shot gun says 3" Chamber, that means I can shoot up to 3" shells? Right? Is that for more power? I know dumb questions but please bare with me!:newbie:


text:
Forget a picture, Stuart Weitzman 'Frame' is worth a thousand fashionable words. The stunning pin dot detail and metallic trim add a glitz to these pumps that is not to be missed!
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Capple Bank Farm sits overlooking the Dales village of West Witton with beautiful and extensive views of Wensleydale. This newly converted property offers luxury accommodation finished to the highest of standards ensuring you make the most of your stay.
Capple Bank Farm for the last 7 years has been awarded AA 5* Status with a "Gold Stars " award, and for the last 2 years has been awarded a Breakfast award. All our rooms have been designed to ensure you have a relaxing and comfortable stay.
Whether you would like to be catered for in the house at our bed & breakfast or be more independent in our cosy holiday cottage, we are able to offer you an extremely comfortable stay. As we are situated in the Yorkshire Dales National Park it means we are ideally situated if you want to relax and tour the Dales or be more active and take advantage of the excellent walking from our door.
It is the scenery and quiet that makes Capple Bank Farm so special - the views of Wensleydale are spectacular! You have no need to drive anywhere, you can simply put your boots on and walk from our door up Penhill and over into Swaledale or further up Wensleydale. If you are looking for a truly restful break then this is the ideal spot.
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Palestinian Authority passport
|Palestinian passport
|Issued by
|Palestinian Authority
|Type of document
|Eligibility requirements
|Residents of areas under the Palestinian Authority.
The Palestinian Authority Passport/Travel Document Arabic: جواز سفر (Jawaz Safar) is a passport/travel document issued since April 1995 by the Palestinian Authority to Palestinian residents of the Palestinian territories for the purpose of international travel.
The Palestinian Authority passport is available to anyone on production of a birth certificate showing that they were born in Palestine. What constitutes "Palestine" for this purpose is not clear. In practice only residents of areas under the Palestinian Authority jurisdiction can apply. Whether Palestinians born outside Palestine could apply for the passport is also not clear.[1]
However, the passport issuance is subject to additional restrictions imposed by the Israeli government.[1] Israel asserts that the requirement is permitted for security needs under the Interim Agreement.[2] The United States regards the Palestinian Authority as not controlling its borders, with all persons entering Palestinian Authority controlled areas being required to obtain permission from Israel.[3]
Between 1924 and 1948, the term "Palestinian passport" referred to the travel documents that were available to residents of British Mandate Palestine. Issued by the High Commissioner for Palestine, they were officially titled, "British passport, Palestine". These passports became invalid with the termination of the British mandate on 15 May 1948.[4] Israeli and Jordanian passports were offered to former British Mandate subjects according to the citizenship they acquired in the aftermath of the 1948 Arab-Israeli War. A significant number of Palestinian Arabs, especially in the Gaza Strip and those who found refuge in Syria and Lebanon, remained stateless, as Egypt, Syria and Lebanon did not allow them to integrate as citizens.
The Egyptian-controlled All-Palestine Government issued All-Palestine passports between 1949 and 1959 to Palestinian residents of the Gaza Strip and Egypt. However, passport holders were not permitted to move freely into Egypt. In the meantime, Transjordan annexed the West Bank and Palestinian residents of the West Bank became citizens of Jordan, and were entitled to a Jordanian passport.
After the 1967 Six-Day War, during which Israel captured the West Bank from Jordan, Palestinian Arabs living there continued to have the right to apply for Jordanian passports and live in Jordan. Palestinian refugees actually living in Jordan were also considered full Jordanian citizens. In July 1988, Jordan severed all legal and administrative ties with the West Bank. Any Palestinian living in Jordan would remain a Jordanian citizen; but residents of the West Bank would not.
Jordan continued to issue passports to Palestinians in the West Bank, but they were for travel purposes only and not as indication of citizenship. Palestinians in the West Bank who had regular Jordanian passports were issued with temporary ones upon expiration of the old ones, and entry into Jordan by Palestinians became time-limited and considered for tourism purposes only. Any Jordanian citizen found carrying a Palestinian or Israeli passport had his/her Jordanian citizenship revoked.
On 2 April 1995, two years after the Oslo Accords of 1993, the Palestinian Authority started issuing Palestinian Authority passports to the public in the self-ruling areas of Gaza and Jericho. These passports retained the personal ID number of the Israeli Civil Administration.[5]
Since Hamas took control of the Gaza Strip in 2007, it has been responsible for the issue of Palestinian Authority passports there.[citation needed]
Implications of the passport[edit]
Palestinians regard the passport as a 'crucial symbol of nationhood.'[6] The recognition of the passports by other countries has been cited as evidence of recognition by them of the State of Palestine and/or Palestinian nationality and citizenship. As of 1997, Palestinian authorities had not issued a passport in the name of the State of Palestine.[7] While the United States Government recognizes Palestinian Authority passports as travel documents, it does not view them as conferring citizenship, since they are not issued by a government which the U.S. recognizes.[1] Egypt, Jordan and the United Arab Emirates have indicated only (in May 2002) that the passports, along with valid visas or other necessary papers, would allow their holders to travel to their countries.[1]
In October 2007, a Japanese Justice Ministry official said, "Given that the Palestinian Authority has improved itself to almost a full-fledged state and issues its own passports, we have decided to accept the Palestinian nationality". The decision followed a recommendation by a ruling party panel on nationality that Palestinians should no longer be treated as stateless.[8]
Passport note[edit]
The document contains a note on the second page (inside of the cover) stating:[9]
- THIS PASSPORT/TRAVEL DOCUMENT IS ISSUED PERSUANT [sic] TO THE PALESTINIAN SELF GOVERNMENT AGREEMENT ACCORDING TO OSLO AGREEMENT SIGNED IN WASHINGTON IN 13/9/1993.
See also[edit]
- ^ a b c d INS Resource Information Center (May 20, 2002). "Palestinian Territory, Occupied" (PDF). UNHCR. Retrieved 2009-01-24.
- ^ UNHCR 17 Dec 1998: Palestine/Occupied Territories: Information On Passports Issued By The Palestine National Authority
- ^ Country Reports on Human Rights Practices for 1997. 1998. United States Department of State. Washington, DC. United States Government Printing Office.
- ^ Artz, 1997 p. 77.
- ^ Parsons, Nigel Craig (2005). The politics of the Palestinian Authority: from Oslo to al-Aqsa. Routledge. p. 298. ISBN 978-0-415-94440-3. Retrieved 2010-01-25.
- ^ Jordan Times, 25 Jan. 1995
- ^ Segal in Kapitan, 1997, p. 231.
- ^ See Japan to recognize Palestinian nationality, KUNA, 10/5/2007 [1]; Yomiuri, Government to recognize Palestinian 'nationality', Saturday, October 6, 2007; and Japan News Review, Government to recognize Palestinian 'nationality', October 6, 2007, [2]
- ^ http://www.uscis.gov/portal/site/uscis/menuitem.5af9bb95919f35e66f614176543f6d1a/?vgnextoid=8d9253bc46d8d010VgnVCM10000048f3d6a1RCRD&vgnextchannel=d2d1e89390b5d010VgnVCM10000048f3d6a1RCRD


text:
Dr. John Wang specializes in general dentistry in Lynnwood, Washington.
Dr. John Wang has been compared 2 times. Details of Dr. Wang's experience as an DDS are available on your free dentist report.
Primary Location for Dr. Wang
Cedar Valley Family Dental
20006 Cedar Valley Rd
Suite 201
Lynnwood, WA 98036
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Dr. John Wang has been identified as specializing in General Dentistry.
He obtained board certification from The Academy of General Dentistry for General Dentistry.
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text:
- 260Promote
Stationery Cards
Crowby Victor Vercesi
Set of folded stationery cards printed on bright white, smooth card stock to bring your personal artistic style to everyday correspondence. Each card is blank on the inside and includes a soft white, European fold envelope for mailing.
love the colors
thank you pigboom!
awesome shot and work around:)
Thanks Nika!
Wow, impressive colours! Great work, Victor!
thank you Balazs!
I love it!
Thxs! :)
really beautiful
Awwwwwesome !)
thank you all for the nice feedback!
Yeah cool!
gorgeous, Victor!!
cheers guys!
so cool, like it a lot.
I love this :D The diamond is perfect.
thank you guys! :)
I want to marry this.
Me too!
way way epic.
thank you so much for the great feedback! love!
Fantastic tones, and colors. Neat!
dont like grows but the theme work good! dopeshow afterall ;-)
love your style. Fabulous.
The colors looks amazing!
Love the artwork! But thats technically a raven, not a crow.
Like it =)
nice work!
Beautiful !
Awesome work, as usual Victor! Superb image!
See More Comments


text:
Product Information:
It's all here! Once you add the product above to your cart, we make it easy to select more items you may need.
Product Details
Porcelain Enamel Integrity (PEI) Rated
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15 Issues of Wine Spectator
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Porcelain Enamel Integrity (PEI) Rated: Yes
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Rocket Lawyer US
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Enclosed is the flyer from an event which I thought might be of interest to you. The speaker will be discussing _________________, which I know is one of your _________________. Would you like to attend the event together? I'd be glad to make the reservations, then pick you up at your office and take you to the event.
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1986 Chevrolet Other • 107,000 miles
My 1986 chevy stepvan doesnt seem to switch gears or get above 35mph. What repairs are necessary?
December 8, 2012.
December 8, 2012.
Take to a trans guy you may have an internal problem with it it cold bea govenor but sounds maybe like a clutch pak.
Dec 8, 2012.
Dec 8, 2012.
1998 Ford Mustang : I recently took my Mustang GT into a Ford service center for a slipping clutch. They told me that I have a self-adjusting clutch and that the clutch assembly needed ...
2 answers • 1998 Ford Mustang
1995 Nissan Maxima SE. Clutch began slipping about a week ago, then 'broke' loose and went to the floor as I was downshifting from 5th to 4th. Kabam! all the way to the floor and no ...
3 answers • 1995 Nissan Maxima • 270,000 miles
My car has been revving up even while in 5th gear and running on unusually high rpm's when any gas is applied, and it has had a burning brake smell if I drove it very far. Recently,the ...
2 answers • 2003 Mitsubishi Lancer • 130,000 miles


text:
Awesome: Hips Dont Lie
Inexact title. See the list below. We don't have an article named Awesome/HipsDontLie, exactly. We do have:
If you meant one of those, just click and go. If you want to start a Awesome/HipsDontLie page, just click the edit button above. Be careful, though, the only things that go in the Main namespace are tropes. Don't put in redirects for shows, books, etc.. Use the right namespace for those.


text:
Need a 16 inch round serving tray to transport entrees or desserts from the kitchen to your dining room? Browse a large selection of serving trays from a wide array of colors like black, burgundy wine and horizon blue at Wasserstrom.com.
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text:
Saw my FB friends recently posting a "cut-and-pasted" privacy notice, supposedly warning Facebook not to use personal information without the account owner's permission, or else… Now what?
Sadly, this is just another hoax, and many have failed to notice. First, how many did actually read the Facebook terms of use and privacy policy when they signed up for an FB account? I bet many of us didn't bother at all – including me.
A quick googling of the terms "UCC 1-308-11 308-103" and "Rome statute" should give everyone a good idea what these are. Go check it out yourself.
Facebook being a "public entity?" Never heard Mark Zuckerberg selling Facebook to the government, or any news on the US federal government taking over Facebook. Though it may sound fun to hear someone addressing "Dir. Zuckerberg of the Facebook State Bureau."
Don't fall to this crap.
It will be great to see Facebook respect everyone's personal information and privacy, but its wishful thinking. Best way to avoid? Stay away from Facebook, or any other social media site.
Happy new year everyone!
Here's the full text –
As of January 5th, 2015 at 12:00 pm Manila time. I do NOT give Facebook or any entitles associated with Facebook permission to use my pictures, information, or post, both from the past, in the present, or in the future.
By this statement I give notice to Facebook it is strictly forbidden to disclose, copy, distribute or take any other action against me based on this profile is private and confidential information. The violation of privacy can be punished by law (UCC 1-308-11 308-103 and Rome statute).
NOTE: Facebook is now a public entity. All members must post a note like this. If you prefer, you can copy and paste this version if you do not publish the statement at least once it will be tactically allowing the use of your photos, as well as information contained in the profile status updates.
DO NOT SHARE you MUST copy and paste this. I will leave a comment so it will be easier to copy and paste!!!I do NOT give Facebook or any entitles associated with Facebook permission to use my pictures, information, or post, both from the past, in the present, or in the future.


text:
Vatican City (Vatican Radio) "Silence and Word: path of evangelization" - that's the theme chosen by Pope Benedict XVI for the Church's 46th World Day for Communications, celebrated each year on the Sunday before Pentecost - on Sunday May 20th this year.
The Pope traditionally releases his message for the occasion on January 24, the feast day of St. Francis de Sales, the patron saint of writers.But does this year's message represent a contradiction in terms?
Fr. Jean-Pierre Ruiz thinks not. He is a biblical scholar and Theology professor at St. John's University in New York, and he's an expert in new media. He says the Pope's choice of "silence and word" as a theme for evangelization and communication is "strangely eloquent…because we live in a world where words in a certain sense have become a cheapened commodity and where people say very often much less than they actually mean."
Fr. Ruiz reminds us that "the Church has been about communicating not only by words, for a very long time – in fact, from the beginning."
He explains "the Church's liturgy for example is not just reading, it's not just text, it's not merely just what we say – it's also the attitude of our bodies, it's also sound without words in terms of instrumental liturgical music."
"It involves the use of all of our senses: our sense of smell in terms of incense and the flowers used to decorate the sanctuary for the Eucharistic liturgy. So I think if we were to reduce communications to just mere words, I think we would be impoverished."
In this program by Tracey McClure, we report on what Pope Benedict says in his Message for World Communications Day and hear Fr. Ruiz's comments -Listen:


text:
Talk:List of crime bosses
From Wikipedia, the free encyclopedia
|This article must adhere to the biographies of living persons policy, even if it is not a biography, because it contains material about living persons. Contentious material about living persons that is unsourced or poorly sourced must be removed immediately from the article and its talk page, especially if potentially libellous. If such material is repeatedly inserted, or if you have other concerns, please report the issue to this noticeboard. If you are connected to one of the subjects of this article and need help, please see this page.
|WikiProject Biography
|(Rated List-class)
Acting bosses?[edit]
Should acting bosses (otherwise known as "street bosses") be added to the page? For reference, an "acting boss" is someone who runs the day-to-day operations of a particular criminal organization while the "official" boss is in prison. Most, if not all, of the New York crime families are currently run by acting bosses. -Craverguy (talk) 00:47, 16 July 2009 (UTC)
Per WP:BLP, identifying a living person as a "crime boss", requires an inline reference with a reliable source. GregorB (talk) 13:33, 26 December 2011 (UTC)
The list is too vague; a sorting of bosses based on nationality, birth/death, years active, crime types is desired. 126.96.36.199 (talk) 13:45, 7 May 2012 (UTC)


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Named for the man who gave me the recipe (and the permission to share it), this is a great jambalaya recipe that combines a large number of meats with generous vegetables and strong Cajun spices.
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text: SDN Members don't see this ad. (About Ads) I'm curious about interventional radiology. The procedures that they do seem so sweet and the patient care setting seems equally as pleasing. So, I'm wondering...how many interventional radiology fellowships are available each year? Is it competitive? Also, would it be foolish to go into radiology...intending to sub-specialize in interventional? Thank you.


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When President Barack Obama took office in 2009, he made a risky calculation: He used most of his political capital to get one cornerstone piece of legislation passed, an overhaul of federal laws expanding healthcare access and coverage. more
By Margaret Talev and Justin Sink
It might surprise you to learn the staff at Blue Cross & Blue Shield of Rhode Island includes two full-time fitness trainers. They work in the fitness center at the health insurer's Providence headquarters, and it's all part of the workplace … more
BY JOHN LARRABEE | Contributing Writer | 8/14/15
A group tasked by the governor to "reinvent" the state's Medicaid system released the second of two reports on Wednesday, which includes a four-year plan with long-term goals aimed at improving the state's publicly funded health care system. more
By Eli Sherman
Blue Cross & Blue Shield of Rhode Island and CharterCARE Health Partners have formed an accountable care partnership for 6,500 BCBSRI Medicare Advantage members who have physicians affiliated with Prospect Provider Group of Rhode Island LLC. more
By PBN Staff
With the Feb. 23 enrollment deadline now over, HealthSource RI said that 83 percent of Year One customers have renewed a plan for 2015. more
By PBN Staff
With the enrollment deadline fast approaching, more people are signing up for health insurance through HealthSource RI, the state's health benefits exchange. more
By PBN Staff
HealthSource RI, Rhode Island's health benefits exchange, has extended the deadline for new and renewing customers to select individual plans to Dec. 31. more
By PBN Staff
Leaders of Neighborhood Health Plan of Rhode Island say strong growth of the company's patient base, staff and revenue highlight growing community needs prioritized by nationwide health care reform. more
By Gabrielle Porter
Contributing Writer | 12/8/14
As the second year of the Rhode Island health benefit exchange gets underway, HealthSource RI is hosting a series of enrollment events around the Ocean State. more
By Harold Ambler
Health insurers are grappling with the question of whether to cover the new pink pill to treat low libido in women, which will hit U.S. pharmacy shelves this year with a prominent warning label for serious side effects such as fainting. more
By Anna Edney and Zachary Tracer


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Michael Krauss Plus
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Michael Krauss thrives on creative challenge - as a cinematographer, broadcast designer and photographer, he finds inspiration from urban decay to scenic landscapes, from live action to motion graphics and typography. His style is comparable to none - exceeding a client's expectation and discovering new insight at all turns.
With a degree in graphic design, Michael headed off on his own to Vancouver where he owned and operated a corporate/industrial photography studio. After five years of enjoying much success, Michael returned to his home in Montréal to further his education, and put his design and photographic skills to use in the communications and entertainment industry. This lead to the next phase in his journey, a prestigious position as Broadcast Designer, Department Head for CTV News in Toronto.
As most creative beings discover, constant challenge is a necessity. Michael's talent and respected work ethic propelled him towards various opportunities with cutting edge companies where he landed positions such as, Art Director, Senior Designer, Producer and Creative Consultant.
Michael now works for himself, utilizing his diverse work experience, and has snagged a few Promax awards along the way. Combining design, photography and motion make for exceptionally creative and provocative work.
Silver ProMax - TFO Brand Identity
Gold ProMax - Bell TV / Express Vu! - HD Promo, Bell TV / Express Vu! - HD Video Capsule
Bachelor of Fine Arts with distinction - Major: Design Art.
Concordia University, Montréal, Quebec, Canada. (1995-1997)
D.E.C. in Graphic Design - Dawson College, Montréal, Quebec, Canada. (1986-1990)


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Grain offerings were made along with communion offerings or burnt offerings in several offerings and also for first-fruit offerings. This was recognized by God in supply blessings and prosperity. This is accompanied by oil and incense. Offerings would be in the form of five lower roasted grain ring-shaped takes early forms that were baked little or deep fat kettle. Eaten by the priest and worshipper. There were drink offerings as well. This consisted of wine porn out on an altar. ' Paul said that he was being pour like a drink offering meaning he was willing to give his life all for himself up for fellow Christians. There is also wave offering. This is were the priest wave offering doing in his hand. It is a motion to and fro the worshipper.
Different Types of Offerings
Harvard must well.
Published by lambed in Christianity on October 23, 2009 | no responses
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Vanderbilt Athletics is proud to announce its partnership with the Rio Grande Fence Company this baseball season. To show its support, Rio Grande Fence Company has again pledged to make a donation to The National Commodore Club for every Commodore home run hit this season. This includes postseason play, and there is no cap!
Click here for the original story.
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Species news archive
UK legal system fails to deter wildlife traffickers
Weak wildlife laws in the UK are threatening some of the world's most endangered animals.
Conservation funds seek closer ties
WWF, The Wildlife Conservation Society (WCS), and the Phoenix Fund will cooperate on conservation ...
Conflict resolution can help save tigers
A project in Malaysia shows that simple changes to livestock management can reduce conflict between ...
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Translocation of 10 greater one-horned rhinoceroses in Nepal has gone ahead despite the current ...
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WWF launches a new panda conservation project
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text:
LAS CRUCES >> It's an "ugly" looking day for Las Crucen Mayra Chavez and other residents.
Chavez was among those who awoke Wednesday to hazy skies and cooler-than-usual temperatures across the city.
"This is a little frustrating, sort of depressing," Chavez said. "You live here long enough you pretty much get used to the wind, the dust, all that junk. But this just doesn't want to seem to go away. I hate the wind, and it's even worse when the sky looks like it does today."
Chavez, and Las Crucens, are going to have to get used to it. The winds and haze will continue through at least Thursday as another cold front, from the east, has moved into the region. Temperatures Wednesday and Thursday will be cooler and could be as much as 15 degrees lower than typical daytime highs in the lower 80s for this time of the year.
"I thought it was just me," said Las Crucen Rigo Marta. "I woke up (Wednesday) morning and it felt cold when I got out of bed. Sure enough, I saw the weather forecast and the temperatures were in the forties."
Las Cruces had an overnight low Wednesday of 35 degrees.
Wind gusts from the east-southeast started kicking up shortly after sunrise Wednesday, and had increased to 32 mph by noon. The National Weather Service forecast calls for winds to persist through Thursday, with gusts to 28 mph possible.
The haze, which came from dust storms Tuesday in Texas, is also anticipated to stick around Las Cruces and the region through Thursday, and possibly into Friday.
As cool as it is Wednesday in Las Cruces, that will change soon enough. Sunday's forecast for Las Cruces includes a potential daytime high of 91 degrees.
The forecast
Wednesday: Areas of blowing dust. Otherwise, sunny with a high near 67. Gusts from the east-southeast as high as 28 mph.
Partly cloudy tonight, with a low near 43
Thursday: A 10 percent chance of showers. Otherwise, mostly sunny, with a high near 68. East wind 15 to 21 mph, with gusts as high as 29 mph. Partly cloudy Thursday night with a low near 44
Friday: Sunny, with a high near 74. Wind will be from the south-southeast 3 to 7 mph. Mostly clear Friday night, with a low near 50
Saturday: Sunny, with a high near 87. Southwest wind 7 to 10 mph. Mostly clear Saturday night, with a low near 54
Sunday: Sunny, with a high near 91. Wind will be be from the north-northwest 6 to 16 mph, becoming west in the afternoon. Winds could gust as high as 23 mph. Mostly clear Sunday night, with a low near 55
Source: National Weather Service