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Medical Malpractice and The Limitation Act 1980
When Lord Woolf was investigating access to the civil justice system in the 1990s, he described the field of medical malpractice litigation as a jurisdiction where it was very difficult to sustain a claim, where more claims were successfully defended at trial than any other jurisdiction, and where the cost of litigating was extremely expensive. That remains the position and the reason is usually the issue of proving causation.
For many acute cases, there is a reason why a person is in hospital in the first place, and if something is done or not done by the ambulance team, the paramedic, the A&E staff or the surgeons, the question arises: has it altered the outcome beyond that which was inevitable? Even where there has been a breach of the surgeon's duty of care (negligence), has it actually worsened the outcome? To put it another way, is there a causal link between the negligence and the injury? Causation remains key to the successful defence of many claims, even where negligence is clear and can be admitted.
Being negligent does not mean being liable. Being negligent and causing an injury means a liability arises. Causation is key…
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2.00 is unstustainable because:
1. its cheaper to produce electricity from gas than coal ( coal electricity generation uses 19,000 trillion BTU) = 19 BCF of gas ( total US gas production is about 65BCF)
2. you can convert gas to oil 6:1 energy price ratio. I mean if you build a plant to do the conversion at 50% efficiency you still get 60% margins. ( a south african company is already building this in louisiana)
3. Natural gas costs 16$ MCF in Japan, that 14$ more. the price of this commodity internationally is high, once export facilities are up (2014) its an entirely differnet market
4. Natural gas in cars, you can save 80% on fuel using natural gas at this price, Trucking companies that converted are getting their investment back in 2 years.
5. cost of production, it costs somewhere north of 4$ MCF on average to produce dry gas from shale, its differenet for every formation but 2$ no where near covers the cost of dry gas production.
so in the long term, i think NVA is a good investment, in term, who knows.
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Read the story "I don't know". It's in the I am lonely group. And plz help him out!
ilovenellyxoxo 16-17 3 Answers 1 Nov 4, 2012 in Hobbies
Can't find it. Link?
Best Answer
yes pl
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Dodge Ram 3500 & Ford F350 are BOSSES when it comes to Pulling Heavy Loads all in 2014
A highlight posted by Tyler Grant on YouTube sets a 2014 Ram 3500 against a 2014 Ford F350 in a packaging turn test. In any case, he got a huge amount of kickback when he posted it as of late.
This is the way he responded: WHATT??
Tyler says in a comment, " When I exchanged this highlight … I can say that I was absolutely oblivious, straightforward pretty much, to the wild commitment that most truck proprietors have to their favored picture. Trust me, this highlight was not planned to maligning, abuse, or censure anyone. It was, and is expected to be enlightening. The fact of the matter is that edges shouldn't flex or bend – they are what holds things together. Body sheets associated with a versatile edge will wrinkle, wrinkle, and spot welds will at last break. The discord was made that make a go at cavorting vehicles have diagrams that flex to help ingest shock. I restrict this thought. Look at trophy trucks, slope surreys, and even earth bikes. Their edges are all unequivocally created using bars that make triangles which we all know can't be distorted by setup (augmentations are made like this). It is the job of the suspension to acclimatize the thumps, potholes, separated, and uneven scene.
Change back to road going vehicles, like these two trucks. Will both of these trucks encounter a situation where the packaging will be put under this kind of nervousness in a reliably condition? Presumably, the answer is no. The reason vehicles continue going so long these days is because they are over-constructed to withstand tensions and strains that we clients will likely never anytime endeavor. Then again, would it say it isn't tolerable to know you can have a vehicle that can and will hold up to this sort of tension if or when it is ever called to do accordingly?
… Every brand of vehicle, especially the "Huge Three", have been through their offer of substandard quality, dull execution, poor reliability, and scrappy life compass. Some of you may not be develop enough to review when vehicles leaving Japan were considered refuse. Look at them now. The same can be said of Ram Trucks. That colossal flight from the common pick-up body style that happened in the before 1990's left a lot of truck proprietors and potential buyers scratching their heads. Transmissions weren't so unimaginable, dashes broke, styling was scrappy. In any case, endeavoring to say that new trucks are going to perform and last like models from 10, 15, and 20 years earlier is like expressing that all that you now know as a 30-year old you knew at ten y


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bayola scandal
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Faith & Life
How to Be Thankful and Content Right Where You Are
The Myth of Private Sin
Faith & Life
I May Be an OK Mom, But I'm a Lousy Psychic.
Dec 03NewSong's Very Merry Christmas Tour! WAY-FM & Liquidbox Trucking proudly present The Very Merry Christmas Tour featuring Newsong, Building 429, Plumb and Reno benefiting Feed the Children! Get your tickets now by clicking here ...See more events


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For all fans of turn-based strategy genre, those that are entirely different from regular wargames or grand strategies, like tactical squad TB based games, hybrids (of real-time and TB) or those featuring an extensive economic system (4X).
The first update of the Exodus Wars: Fractured Empire ALPHA for the new year has just been released on FracturedEmpire.net. Play single-player as the Royal Empire of Man, a much improved AI, the Overwatch order, formation icons and more.
Posted by GR00V3R on Jan 25th, 2013
The first update of the Exodus Wars: Fractured Empire ALPHA for the new year has just been released on FracturedEmpire.net.
This is the most critical and features-heavy update we have shipped yet for the Alpha of Exodus Wars: Fractured Empire, and we hope you will be as excited by what's in this new build as we are.
Please note that the Webplayer Demo has also been updated with most of these features.
New AI
We have replaced the rudimentary AI that shipped with the initial Alpha build with our first version of the proper AI. You will find the AI a lot more challenging now.
Play as the Royal Empire of Man
You can now play single-player games using the Royal Empire of Man or the Guild forces (previously, you could play single-player as the Guild only).
Formation Icons
Much of the feedback we have received to date requested that we make it easier to identify the locations of your formations on the map. As part of our response to this, we are pleased to have implemented formation icons. These should enable you to quickly and easily spot and select your formations, wherever they may be hiding on the map.
We have implemented the Overwatch order. This order allows you to forego moving and shooting in your own activation in favour of shooting with standard effectiveness once if and when an enemy formation moves within the overwatching formation's range and line of sight.
Linux Version
We recently made the first Linux version of the Alpha build available to select gamers (that is, those Linux fans who put their hands up to be testing guinea pigs). The result were, to be honest, surprisingly good!
And now, thanks to the efforts of these intrepid individuals, we are very happy to announce that we have made a mainstream release of the Linux version available for download from FracturedEmpire.net.
Steam Greenlight
You may have seen that we have launched a Steam Greenlight campaign. The response has been amazing—but we can always use more votes!
If you are a Steam gamer, we hope you will login at our Greenlight campaign page and vote for us!


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Ride Of the Century 2012
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For there is always another day.
theinkfly 3 years ago
@eflagella - thanks Erinypops. =) but you know what I'm like.. >.< I will try though.... Love you the mosterestnessessess!!! You need to get your ass one AGAINNNNN >:( me missed you yesterday. =S
eflagella 3 years ago
@BrownEyedGirl97 welcome AmbiBambi!!! i know. =) and remember the same applies to you. i'm always here if you need me. =) love you the mosterestnessessess too!!!! <333 how does one get their ass on...? o.O
ColourfulShadows 3 years ago
A very hopeful poem! Theres always another day to try harder and move on with life!
eflagella 3 years ago
I love it Ambi. <3 It is truly beautiful. And thank you. =) Love you the mosterestness always!!! <333


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- Entire Home
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- Listings where you have your own room but share some common spaces.
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- Listings where you'll share your room or your room may be a common space.
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300+ Rentals · Coco
300+ Rentals · Coco
This little appartment is situated in Marina Loft, a complex located just 10 minutes walking from the center - 2 min by taxi. There are facilities like a little market, a cafeteria and an Italian restaurant. Walk 200 metres and you will find the sea.
This little appartment is situated in Marina Loft, a complex located just 10 minutes walking from the center - 2 min by taxi. There are facilities like a little market, a cafeteria and an Italian restaurant. Walk 200 metres and you will find the sea.
one room in 2 bedrooms house,2 bathroom, 5 min beach 2min center by car. It is place with own balcony, swimming pool, Jacuzzi , party zone, barbecue, 3 min from the stores, restaurants, med centers, diving . own washing mashing , laundry, fen.
This condominium is situated in the beautiful area. A lot of restaurants and any bars, stores and shops. I can help you in any things, with excursions and trips, with rent a bike and a car. There is a medical center for people and animal and dental center too. The bus stop is only 15 minutes from the house. and 5 minutes by car. The quick breakfast is include. If you want to use a/c you should pay.
Look for the lightning bolt for faster booking
This is by far the nicest and most comfortable unit in Torres Del Coco and Las Palmas residential.The complex has a lovely swimming pool, Security Guard,Laundry facilities, Lots of parking and nice rancho to spend the day. Ocean 200 m
30 min. drive from Liberia Airport; 3 minutes drive to Playa Del Coco, 900 meters to a beautiful, award winning Ocotal Beach. This 700 sq. foot apartment with swimming pool and mountains view offers fully equipped kitchen, A/C, fans and safe, Wi-Fi..
Accommodates four persons. Villa Dolce Vita guests enjoy: 24 hour security on site, free parking, Wi-Fi, barbeque, 7 swimming pools in the complex, colorful Guanacaste's wildlife, safe swimming, no riptides; Guanacaste's best snorkeling; quiet and relaxed sunbathing, peaceful environment away from the party atmosphere in Coco. The interior is brand new (2012) and decorated in a contemporary style. The master bedroom has comfortable queen bed and WC. Guest bedroom has two comfortable twin be...
Fully furnished and equipped 2 bed/2bath condo with Infinity pool and beautiful mountain views located in Playa Ocotal on the northwest coast of the Guanacaste Province. Just 40 minutes away from Liberia International Airport. We have a fully equipped kitchen with all the amenities you would need. 2 new bar stools to sit around the island and enjoy a casual conversation. We have WIFI availability, supply all towels and sheets. A washer and dryer in the unit make laundry easy, however we a...
Look for the lightning bolt for faster booking
three blocks from the beach, and 5 minutes from main street coco where you can find great places to dine such as Hard Rock Café, Casino, Z Lounge, Lizard bar, Banks, food market, church services, and more such as hot springs, volcano, river boat.
Enjoy the pool area as well the BBQ ranch, is set an convenience way so you can enjoy the outdoors activities after day on the beach. We can also boot a daily tour to the volcano, hot springs, Nicaragua, golf, sport fishing, scuba diving, Panama tour, cocodriles, canopy, surfing, horseback riding. To our guest we will welcome with a brief about what activities can be engages while coco beach, money exchange rate, safety information and more. three blocks aways from the enjoyable pacific w...
Cocomarindo Condo Gnd floor, 1 Bedroom,1 bathroom, kitchen, living/dining room, pool, security, BBQ rancho, 400 sq.ft (37 m2) The biggest swimming pool all over Guanacaste over 2700 sq.ft.Great condo located in an exclusive complex 5 min to beach.
Resort setting condominium - Spotless one bedroom, one bathroom, living room/kitchen combo. This comfortable home away from home comes complete with all amenities and lots of extras. 32 inch LCD Cable TV in living room and 20 inch LCD TV in the bedroom. Included are international multilingual stations. Internet with a USB DATA CARD. We provide transfer services to all near by beaches.Rent a driver and Rent a Car available at the best prices. The tropical grounds are beautifully landscape...
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Located in an in gate community with 24/7 guard. Nicely and newly decorated studio at 1 block from the beach! Accomodate 3 people maximum with a double bed and a smal pull out couch
Nice fully equiped studio in an in gate community with security guard 24/7. Wifi Swimming pool Laundry room BBQ area
Fully furnished house with private pool located in Coco Beach, less than 1k from where all the action occurs during the day and night, but far enough to relax and spend an excellent vacation with family and friend, reading a book, havin
Look for the lightning bolt for faster booking
We welcome you into our house located right off the center of Playas del Coco and yet surrounded by nature. We offer you a comfortable room in a family atmosphere where you'll be able to relax under the mango tree after your day of fun in Coco!
Our home is a typical wooden house located on a piece of land where we live with our dog, a family of ducks and the howler monkeys hanging in the branches. The way it is built, the breeze always flows through the house and keeps it fresh despite the Guanacaste sun. This way, your room is always cool. The room has a double bed, and a bunk bed that is double on the bottom and single on top. Very humbly, your host is also an excellent cook! So if you want to start your day with a good br...
Bed: 2 Size: 90m2 / 1000sq.ft This Gorgeous Condo is located in the heart of Coco Beach, only 3 minutes walk to the beach and less that 5 minutes walk to Downtown, easy access to everything..Fully Furnished. Nice swimming pool with the zone of barb
good clean room for the small price The room has ceiling fan, air conditioning unit is available for an extra $5 per nightfi .The price 1-2 days of accommodation increases a price * 2. 24\7 It is very close for everything we have a very good public transportation from near Liberia city as well the capital San Jose.the meeting at the airport Liberia of $40 San Jose $200 is possible Coco is close to everything, volcano, Rincon de la vieja national park, river boat tours, fishing, snorke...
Look for the lightning bolt for faster booking
Private room and Bathroom in a nice spacious, confortable and really friendly place with swimming pool and jaccuzi just in front of the patio! With free laundy/dryer and unlimited Wifi 2min walk from beach, 10min walk from down town Enjoy Coco!
The place is located in a really safe reasort, at 2 min walk from the beach, 2min walk from restaurants, supermarket and coffee shops and 10min walk from down town, or 1.8$ by taxi, with more supermarket, fruits and veggies markets, bars, restaurants, shops... The perfect location to enjoy Coco without the noise of the city center. You can either spend you day relaxing by the quite pool or at the beach! Playa del Coco has a lot of beauty to offer. You can enjoy the black sand beach, disco...
All Apartments comes with fully furnished Kitchen, A/C ,Cable-TV, Wi-Fi., Balcony or Terasse ,Pool with Poolbar, BBQ, private Parking, daily cleaning,hot Water. We are located just 50mtr. from the Beach and Center with all the Bars , Restaurants,Farmacies and Supermarket. a disposizione di ogni abitazione c'è un terrazzo privato e due ranchi per poter bere qualcosa o giocare a carte o semplicemente fare qualche chiacchiera Tutto il giorno vi è personale a disposizione anche per poter org...
Villa Vista Perfecta No 4, Playas del Coco, Guanacaste, Costa Rica Type:Residential Style:252sq.ft Roof Top Terrace Development Level:Built Bedrooms:2 "Large Balcony + terrace" Bathrooms:2 "1 En-suite" Size:794 sq. ft. "
633.50 Living Space and 160 sq.ft terrace" These ocean view condos have been built close to upscale Vista Marina development in Playas del Coco, Guanacaste. This 2 bed/2 bath condo has just been furnished to a high standard and equipped with modern up to date appliances. Vista Perfecta is located about 5-7 minutes drive from the beach, 3-5 mins from Automercado Supermarket. There is 633.50 square feet of living space under air-con and a 160 square feet balcony off of the upstairs bedroom...
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This is a shared room with 5 beds, 1 private bathroom. The room is on the second floor of a house, perfect for big groups or families. Comfortable, peaceful, you have access to a common area and is in a very safe location.
The shared room is spacious and big enough for 5 people comfortably. There is a refrigerator, kitchen nook, sink and a hot plate/plug in pan. Each guest has their own bed, and there are shelves to put their things Guests have access to the second floor which is where the rooms and common area is. You can also go downstairs on the deck which has more hammocks and chairs. If you want to use the microwave, you are welcome to use that on the first floor I live on the first floor of this house...
casa frente al mar , amplio parqueo , decorada con motivos de playa , cuatro cuartos , dos baños , no es lujos ,pero comoda , aire acondicionados en las cuatro habitaciones , dos con camas queen,dos con individuales . piscina pequeña de inflar 3m amplisimo parqueo , toda la casa cerrada con malla la casa se encuentra a 300 mts de el centro del pueblo , muchos restaurantes , almacenes , tiendas de artesania , paseos en bote ,
The Pura Vida Townhouse is a perfect getaway . It is on a hilltop just a kilometer away from beautiful Ocotal Beach and 3 kilometers from downtown Coco. It is very private and quiet , with great views and almost everything is new in this condo .
Large 1 bedroon, 2 full baths, fully equipped kitchen with bistro table, Living room with futon couch.Queen sized bed, with patio adjacent to bedroom. Magnificent mountain views from kitchen and living area. Located on a hilltop.This unit includes highspeed internet, cable, hotwater.Electrcity is shared. This is a very private hillside condo complex with only a few neighbors . The pool is located on a lower level in the same complex . There is a BBQ area and a big hammock for guests use ....
Welcome to Heavenly Sands! Escape to your Costa Rica getaway! Playa Coco is a quaint town that is conveniently located 20 minutes from Liberia International Airport. You land and you're ready for your stay.
Condo is a large studio with a half kitchen on the 2nd floor of a two story project that is just down the block from the beach. Pool/Laundry/store on site. PURA VIDA Playas del Coco is one of the oldest beach communities in Guanacaste Province, Costa Rica. It is a bay community with many charter and fishing vessels. This charming town is a gateway to Witches Rock and Ollie's which are famous surfing locations. Playa de Coco is central, enabling you to visit many other popular and beau...
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text: Redman – Gilla House Bounce + Big Girls 2010 Like Tweet +1 IHHM Posted on April 7, 2010 Category: Audio, Free Music Downloads, Music (Legacy Category) Two new Red Man joints, check em out. Redman – Gilla House Bounce (Download) Redman – Big Girls 2010 (Download) IHHM About: iHipHopMusic.com is brought to you by Glenton Samuels aka Chozen, CEO & Founder of Covanant LLC. Follow Me: Instagram / Twitter / Facebook / Google+ / Redman Related Content Redman, Ready Roc & Runt Dawg – Ironman Redman & Runt Dawg – Zip Lock Redman, Ready Roc & Runt Dawg – Ahh Yes + My House (Remix) Bun B – Stop Playin (feat. Royce Da 59 & Redman) Redman – Just Dont Give A f**k Freestyle Smokey Robotic – No Reality (feat. Redman) Latest Chatter Are you a business man or an artist,Politicians an... DoraSandy2 | Read More Some great pics of Sexy Ass http://manfromiran.com... MehdiKalbasiAshtari | Read More hello 50... benbros yankey | Read More i like you 50 cent... benbros yankey | Read More 0 comments   Get Livefyre FAQ Sign in + Follow Post comment Link Newest | Oldest


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Revolving around three pairs of characters with very different relationships, the episode has some heartbreaking, but really great, drama. Read More »
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9 people have liked this place on our app
92-98 Newgate Street,
Newcastle upon Tyne,
In the heart of the city, Lau's 202 Buffet House brings international cuisines together with a fresh and extravagant approach to the world buffet. After being in business for over three years, Lau's has increasingly grown in popularity due to its fabulous buffet-style dining at a quality rarely experienced.
Diners are welcomed into a wonderfully chic interior and presented with an exquisite choice of world cuisine. Let the friendly and efficient team see to your every need; they'll make sure your glass is never empty and offer you such a vast array of beautiful dishes, you'll feel utterly spoilt for choice.
'The island' is the restaurant's stunning centerpiece – a fully stocked sushi bar, a tandoor oven, a teppanyaki and grill with chefs on hand to freshly prepare your order. Here you can witness talented experts whip up deliciously tempting food right in front of your eyes. Enjoy a decadent evening of traditional Chinese, Japanese, Italian and Indian food alongside many other international cuisines, with an extensive choice of seafood and dishes from the live-cooking island. The drinks menu is similarly wide-ranging, offering a large selection of beers, lagers, ciders, wines and spirits to suit any patron's palate. There really is no excuse to pass up this unique buffet experience.
Open: Mon-Sun 11.30am-10.30pm
t: 01912314466
w: www.laus202buffethouse.com


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The bracelet that keeps you safe.
In an emergency it's often impossible to reach for your phone. Safelet is a 'smart bracelet' that allows you to alert friends, family and the police, where you are and that you need help.
Reserve your Safelet today and save $20 off the future retail price.Pre-order now!
What makes Safelet great
Safelet and Safelet+
|Safelet app: Invite friends and family
into your guardian network
|Sends text alert and location
to guardian network
|Choose between 5 colors
|Dials an emergency number
now $79
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How does Safelet work?
Freedom is about feeling safe…
Returning home from a night out. Going on a date with someone new. Getting some exercise in the park. We believe that every woman deserves to feel safe, wherever they are, whatever they're doing.
Safelet is designed so that when the wearer is in danger, they can alert their chosen personal network of friends and family. Stylish yet discrete, Safelet is absolutely focussed on being as simple to use as possible in high stress, emergency situations; a moment when it is often simply not possible to reach for your phone.
The people that care about you want to be there when you are most in need. Now, with Safelet, they can.


text:
DNG An Experience to exceed your expectations
- Thousands of properties for sale and to rent throughout Ireland
- Expert property valuations
- National award winning estate agent
DNG Residential Market Review Q3 2015 . ....read more
Please submit your details below and our Client Services department will be in touch to see how DNG can help. Alternatively, call DNG free on 1800 364 364.
Please register your property interests below and we will send you links to property that match your interests as soon as they are published on DNG.ie


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"Students and educators will find this series relevant and current....Educators will find the series a valuable resource for an information literacy curriculum. This is an excellent source for a high school library."
Library Media Connection, June 2015
"This well-organized, informative textbooklike set presents information about five common types of addiction and asks readers to examine sources, analyze data, and come to conclusions about the seriousness of the addictions discussed and how they impact peoples' lives and relationships. Well-chosen quotes from primary sources are presented, as well as cited research, graphs, tables, and data charts. This particular series will be valuable to students doing research..."
School Library Journal, April 2015
"A colorful, infographic-style timeline precedes each introduction and immediately draws the reader's attention. Each volume has a wide variety of information which will pique the interest of students. Each book is well-researched, citing many peer-reviewed sources, making these books ideal for research. Insets featuring highlighted topics or words in context break up the text and enhance readability. The illustrations, photographs of artifacts, and medieval artwork bring the era to life. With the same format, moving from one book to the next will be seamless. This series will not disappoint casual readers or researchers looking for quality information about Medieval times"
Library Media Connections, March 2015
"A five-book series on the former Soviet Union, these brief but balanced volumes contain enough information for an introduction to the subject, though only enough to supplement in a survey course, or serve as enough information to whet the appetite of students who may want to delve further into the topics. Each volume is colorful and eye-catching, continuing the yellow and red color scheme of the covers, each of which includes a map of the area being discussed, and the first page of each chapter mirrors the cover colors....this series deserves a place in all secondary school collections."
Voya, February 2015
"Cell phones have become so pervasive; this timely series deals with several aspects of them in today's society....This is an extremely balanced, well-written series on a very timely and important topic."
Library Media Connection, March 2015


text: Breaking the Top 100 By Mike McHuman Published August 17, 2008 More Info » Full Credits Mike McHuman Uploader Stats & Data 0 Funny Votes 0 Die Votes 74 Views Published August 17, 2008 Categories: Blogs Keywords: blog I just became the 95th most talkative person on Funny or Die. I don't know whether to laugh or cry. Browse Related Comments 20+ more View All ▶ Mike McHuman Vaguely Related Pics & Words Vaguely Related Videos Advertisement


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Truck Stops: Where to Find Lunch on Wheels
Every morning, we'll let you know where the area's food trucks are rolling
Farragut Square (17th and I sts., NW), where you'll find Merlindia from Fojol Bros., the Cheesecake Truck (first stop), a Sâuçá truck, and Pi Truck.
Franklin Park (13th and K sts., NW), where you'll find Sabor'a Street, Dangerously Delicious Pies, Phonomenon, and Sinplicity.
L'Enfant (around Sixth St. and Maryland Ave., SW), where you'll find The Ficelle, Curbside Cupcakes (Pinky 1's first stop at the Metro), and Sol Mexican Grill.
Metro Center (around 11th and G sts., NW), where you'll find Benethiopia from Fojol Bros., Dippin Dots, Yellow Vendor (12th and F sts., NW), Cap Mac, and PORC.
Northern Virginia, where you'll find Capital Empanadas (Courthouse at Wilson Blvd. and N. Uhle St.), District Taco (Crystal City), a Sâuçá truck (Rosslyn), and Sweet Fleet (Rosslyn, Ballston, Shirlington).
Patriot's Plaza (Third and E sts., NW), where you'll find Eat Stix.
State Department area (20th St. and Virginia Ave., NW), where you'll find Carnivore BBQ, Basil Thyme, and Curbside Crab (Foggy Bottom).
Union Station, where you'll find a Sâuçá truck.
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Follow the Best Bites Bloggers on TwitterMore>> Best Bites Blog | Food & Dining | Restaurant Finder


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Exiles In Paradise
|Running Time: 90 mins.
|Genre: Drama
Dmitri Boudrine
Benita Ha
J R Bourne
Tatiana Chekhova
All Cast & Crew >>
Summary:Russian actor Dimitri, Chinese dissident Ai Ling and North American lawyer Steve come together at the fringes of society. They don't trust each other, yet they have no choice as Ai Ling and Steve try to save Dmitri from being deported.


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Woman, 64, killed when snow-laden roof collapses on top of her
Bonnie Dewey was clearing snow off a deck in Gooderham, Ont., Saturday when a roof collapsed on top of her.
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Bonnie Dewey was being her kind-hearted self when she offered to sweep snow off her mother's deck Saturday afternoon.
Minutes later she was dead – trapped under the weight of a snow-laden roof that collapsed on top of her.
Police and paramedics rushed to the home in Gooderham, north or Peterborough, but by the time they arrived, Dewey was without vital signs. Attempts to revive the 64-year-old woman were unsuccessful.
The collapse appears to have been caused by the weight of the heavy snow on the roof, and recent precipitation.
"We certainly have had a significant amount of snowfall over the past while. There was an extreme amount of precipitation on that roof and everyone else's roof," said Const. Paul Potter with the Haliburton Highlands OPP.
"It's certainly a tragic set of circumstances here."
Now Dewey's family is remembering her as a special woman who was always filled with positivity.
"She knew how to win your heart. She was not prejudiced or judgmental or anything. She was just that golden person," said Ida Schultz, Dewey's stepdaughter.
Dewey married Schultz's father, Jerry Dewey, 16 years ago — an anniversary the couple celebrated earlier this month.
Dewey moved to Gooderham from Oshawa for the relationship, Schultz said. For years, she worked as a personal support worker, before turning her attention to volunteer work with Community Care Haliburton County and the town's Pentecostal church.
"She was just always there with the most loving, kind heart," Schultz said.
Family was "always number one" for Dewey, who is survived by her biological son, her stepson, and Schultz.
Dewey was "very hands on" with her two granddaughters and two great grandchildren, Schultz said. She loved to have them over on weekends and during the summer, taking them to church and to swimming lessons.
Instead of getting angry, Dewey always responded with love, Schultz said, adding that she didn't remember a single time when she was in trouble with her stepmother.
"It takes a very special person to do that," Schultz said, her voice choked with emotion.
"No matter how bad things were, she always found something positive in it. I never heard a negative thing out of her mouth."
Dewey's husband, Jerry, summed up his wife's essence with a single sentence.
"She was a beautiful woman," he said.
Top News
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Changes related to "ALBERTA: Populated Places Table A-H"
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Law Returns & Extends in Dr Faustus Post-Injury
Editorial Staff • West End • 26 Mar 2002
All theatregoers who had tickets for the missed performances have been offered tickets on alternative dates. Given the full houses – which sold out weeks ahead of the opening night on 18 March (previews from 7 March) – this has necessitated a week-long extension to the limited season. Originally booking to 27 April, Dr Faustus will not continue until 4 May 2002.
Law plays the title role in Christopher Marlowe's 16th-century morality tale about the man who sells his soul to the devil in exchange for knowledge, wealth and power. Also in the cast are Richard McCabe, Annette Badland, David Fielder, Bohdan Poraj, Tom Smith and Ofo Uhiara.
Dr Faustus is directed by David Lan and designed by Richard Hudson, with music by Murray Gold, lighting by Matthew Richardson, sound by Crispian Covell and choreography by Kate Flatt.
The play is a co-production between the Young Vic and Natural Nylon Theatre, formed last year by Law with fellow actors Ewan McGregor, Johnny Lee Miller, Sean Pertwee and Law's wife Sadie Frost as a spin-off of their existing film production company. This is the first Natural Nylon stage project; others planned include an adaptation of Chekhov's Three Sisters, written by Christopher Hampton and directed by Sean Matthias, and The Collector, adapted by Mark Healy from the novel by John Fowles and directed by Mark Clements.
- by Terri Paddock
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[[folder:Marvel Cloak and Dagger]]
* FamilyUnfriendlyAesop: The reason for the FlipFlopOfGod noted on the trivia page; the "latent mutations" were added because the original origin had the implication that drugs can give you superpowers.
* FamilyUnfriendlyAesop: Jack gives Davey really dumb advice: run across gunfire, run through traffic, steal things, [[spoiler: and overcome his nonviolence so he can shoot at the bad guys]]. Even more oddly, [[spoiler: it works out well for Davey every time.]]


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Are you M O Khrenov?Claim your profile
Publications (32)30.64 Total impact
- Doklady Biological Sciences 09/2015; 464(1):260-262. DOI:10.1134/S0012496615050087
Article: Modulation of inflammatory response in mice with severe autoimmune disease by thymic peptide thymulin and an inhibitor of NF-kappaB signalling[Show abstract] [Hide abstract]
ABSTRACT: To investigate some cellular and molecular aspects of the autoimmune response and anti-inflammatory efficiency of potential therapeutic agents in a severe form of experimental autoimmune encephalomyelitis (sEAE), an inhibitor of NF-kappaB signalling, IKK Inhibitor XII, and/or thymic peptide thymulin, were injected intraperitoneally at 1.8 and 0.15mg/kg e.o.d, respectively, to C57BL/6 mice immunized with myelin oligodendrocyte glycoprotein and several adjuvants. The immunization induced high lethality in three weeks. The biphasic cytokine response observed in earlier and delayed phases was attributed to the activity of Th1 and Th17 cells, respectively. Phosphorylation of RelA protein from the NF-kappaB family increased during the earlier phase and decreased in the delayed phase. SAPK/JNK signalling protein and heat shock protein Hsp72 significantly increased in lymphocytes. Both the IKK Inhibitor XII and thymulin reduced disease severity, attenuated immune imbalance, and increased mouse life-span. Co-administration of the agents produced no additive effect. Both the inhibitor and thymulin reduced the Th1 response but not the Th17 response. Therefore, RelA-associated Th1 activation and RelA-independent Th17 activation occurred in sEAE. Thymulin and the inhibitor demonstrate similar patterns of activity, potentially through the RelA pathway inhibition, resulting in a partial therapeutic effect on the animals' health status. Copyright © 2015 Elsevier B.V. All rights reserved.International Immunopharmacology 02/2015; 25(2). DOI:10.1016/j.intimp.2015.01.021 · 2.47 Impact Factor
Article: The role of the NF-κB, SAPK/JNK, and TLR4 signalling pathways in the responses of RAW 264.7 cells to extremely low-intensity microwaves[Show abstract] [Hide abstract]
ABSTRACT: Purpose: To investigate the role of the toll-like receptor 4 (TLR4), nuclear factor κB (NF-κB), and stress activated protein kinases/Jun N-terminal kinase (SAPK/JNK) signalling pathways in the responses of RAW 264.7 macrophages to low-intensity microwaves (MW). Materials and methods: Three inhibitors of TLR4, SAPK/JNK, and NF-κB signalling, namely CLI-095, SP600125, and IKK Inhibitor XII, respectively, were added to cultured RAW 264.7 macrophages before MW treatment. Results: MW exposure resulted in stimulation of RAW 264.7 cell activity manifested by increases in cytokine production and the stimulation of cell signalling. The blocking of a key kinase of the NF-κB pathway by IKK Inhibitor XII resulted in decreased MW-induced TLR4 expression and increased SAPK/JNK and NF-κB phosphorylation in irradiated cells. In addition, IKK Inhibitor XII significantly decreased tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin 1α (IL-1α), interleukin 6 (IL-6), and interleukin 10 (IL-10) production in both exposed and unexposed RAW 264.7 macrophages. Inhibitor SP6000125 did not prevent an MW effect on signal proteins with the exception of decreased SAPK/JNK phosphorylation in RAW 264.7 cells. Cytokine production was markedly decreased in MW-exposed cells cultured with SP6000125. The inhibitor of TLR4, CLI-095, did not affect signal proteins and cytokine production changes in MW-exposed cells. Conclusions: The results suggest that low-intensity MW promotes macrophage activity via mechanisms involving cellular signalling, particularly the NF-κB pathway.International Journal of Radiation Biology 12/2014; 91(4):1-24. DOI:10.3109/09553002.2014.996261 · 1.69 Impact Factor
Article: Changes in immune cell signalling, apoptosis and stress response functions in mice returned from the BION-M1 mission in space[Show abstract] [Hide abstract]
ABSTRACT: To explore the effect of the spaceflight environment on immunity in animals, C57/BL6 mice flown on a 30-day space high-orbit satellite mission (BION-M1) were analysed. Cytokine response in mice was measured in tandem with the following parameters: the synthesis of inducible forms of the heat shock proteins HSP72 and HSP90α; activity of the NF-κB, IFR3, and SAPK/JNK signalling pathways; and TLR4 expression. In addition, apoptosis in the thymus was measured by caspase-3 and ph-p53/p53 ratio testing. In response to flight environment exposure, mice had a reduction in spleen and thymus masses and decreased splenic and thymic lymphocyte counts. Plasma concentration of IL-6 and IFN-γ but not TNF-α was decreased in C57BL6 mice. The NF-κB activity in splenic lymphocytes through the canonical pathway involving IκB degradation was significantly increased at 12 h after landing. One week after landing, however, the activity of NF-κB was markedly decreased below even the control values. Non-canonical NF-κB activity increased during the whole observation period. The activities of SAPK/JNK and IRF-3 were invariable at 12 h but significantly increased seven days after landing. The expression of Hsp72 and Hsp90α was somewhat increased 12 h (Hsp72) and seven days (Hsp90α). TLR4 expression in splenic cells was significantly increased only at 12 h, returning to normal seven days after landing. To assess the apoptosis in thymus lymphocytes, caspase-3 and levels of p53 protein along with its phosphorylated form were measured in thymic lymphocytes. The results indicated that the high-orbit spaceflight environment caused an increase in the level of p53 but more notably in the activated, phosphorylated form of the p53 protein. The calculated ratio of the active to inactive forms of the protein (ph-53/p53) 12 h after landing increased by more than twofold, indicating the apparent induction of apoptosis in thymus cells. Interestingly, seven days after the landing, this ratio was not restored, but rather increased: the specified ratio was four times higher compared to the ground-based control. Measurements of caspase-3 in thymic cells indicated more expressive increase in apoptosis. Taken together, the results of the present study indicate that spaceflight induces an imbalance in the immunity of mice, showing variation in signalling, apoptosis and stress response that are not restored by seven days after landing. These changes are distinguished from classic stress-related alterations usually caused by conventional stressors.Immunobiology 10/2014; 220(4). DOI:10.1016/j.imbio.2014.10.021 · 3.04 Impact Factor
Article: The NF-κB, IRF3, and SAPK/JNK signaling cascades of animal immune cells and their role in the progress of type 1 diabetes mellitusDoklady Biological Sciences 07/2014; 457(1):255-7. DOI:10.1134/S0012496614040073
Article: Anti-Inflammatory Effects of IKK Inhibitor XII, Thymulin, and Fat-Soluble Antioxidants in LPS-Treated Mice[Show abstract] [Hide abstract]
ABSTRACT: The present study was designed to compare the anti-inflammatory effects of several agents applied in vivo, namely, a synthetic inhibitor of the NF-κB cascade, fat-soluble antioxidants, and the thymic peptide thymulin. Cytokine response in LPS-treated mice was analysed in tandem with the following parameters: the synthesis of inducible forms of the heat shock proteins HSP72 and HSP90α; activity of the NF-κB and SAPK/JNK signalling pathways; and TLR4 expression. Inflammation-bearing Balb/c male mice were pretreated with an inhibitor of IKK-α/β kinases (IKK Inhibitor XII); with thymulin; with dietary coenzyme Q9, α-tocopherol, and β-carotene; or with combinations of the inhibitor and peptide or antioxidants. Comparable anti-inflammatory effects were observed in inflammation-bearing mice treated separately with thymulin or with dietary antioxidants administered daily for two weeks before LPS treatment. When LPS-injected mice were treated with the inhibitor and antioxidants together, neither plasma cytokines, signal proteins, nor heat shock proteins recovered more efficiently than when mice were treated with these agents separately. In contrast to antioxidant diet, the thymulin was shown to increase the effect of IKK Inhibitor XII in preventing IKK activation in LPS-treated mice.Mediators of Inflammation 06/2014; 2014(4):724838. DOI:10.1155/2014/724838 · 3.24 Impact Factor
Article: In vitro and in vivo effects of some inhibitors of signal cascades on cytokines and signal proteins production in raw 264.7 macrophage cells and in mouse lymphocytes[Show abstract] [Hide abstract]
ABSTRACT: In vitro and in vivo effects of some inhibitors of the activity of signal cascades NF-κB and SAPK/JNK, and the TLR4 receptor on the immune cells activity were studied. To evaluate in vitro effects, the macrophage-like RAW 264.7 cells were cultured with each of the inhibitors, namely IKK inhibitor XII, SP600125, CLI-095, and OxPAPK (the first two are the inhibitors of NF-κB, SAPK/JNK cascades, and the last two compounds are the inhibitors of the TLR4 receptor activity). On the whole, all of the used inhibitors did not induce pro-inflammatory response in RAW 264.7 cells. On the contrary, the inhibitor of SAPK/JNK cascade, and, especially, the inhibitor of NF-κB cascade significantly decreased production of the TNF-α, IL-1, IL-6, IFN-γ, and IL-10 in RAW 264.7 cells. In these cells, the inhibitors substantially decreased "back-ground stress response" of macrophages, differently reducing a production of heat shock proteins, HSP72 and HSP90-α, and diminishing phosphorylation of signal proteins from NF-κB and SAPK/JNK cascades. Results of in vitro experiments suggest that the inhibitor of NF-κB activity was the most effective. It was this inhibitor that was intraperitonealy injected in Balb/C male mice in the in vivo experiments in order to study its effect on the activity of immune cells. Results showed that IKK Inhibitor XII applied in vivo did not induce pro-inflammatory response in mice, but decreased the activity of NF-κB cascade, and lowered HSP90-α expression in mouse splenic lymphocytes. So, among the studied compounds, IKK Inhibitor XII seems to be a very effective inhibitor that may be used to decrease cytokine and stress response in various pathologies.Biophysics 01/2014; 59(1):86-90. DOI:10.1134/S0006350914010126
Article: Dietary liposoluble antioxidants protect mouse immune cells from the toxic effects of atmospheric ammoniaDoklady Biological Sciences 03/2013; 449(1):113-5. DOI:10.1134/S0012496613020154
Article: Inhibitors of TLR-4, NF-κB, and SAPK/JNK signaling reduce the toxic effect of lipopolysaccharide on RAW 264.7 cells[Show abstract] [Hide abstract]
ABSTRACT: The present study was designed to examine and compare the effects of three suppressors on the cytokine response in tandem with examining: the synthesis of inducible forms of heat shock proteins; HSP72 and HSP90α; activities of NF-κB and SAPK/JNK signaling pathways; and TLR4 expression. Pre-treatment with inhibitors offers promise as protective means to lower the activity of these cascades, thereby circumventing the formation of excessive amounts of pro-inflammatory molecules. Three inhibitors of TLR4, SAPK/JNK, and NF-κB signaling, namely CLI-095, SP600125, and IKK Inhibitor XII, respectively, were added to cultured RAW 264.7 macrophages before the Escherichia coli lipopolysaccharide (LPS) application. Treatments of RAW 264.7 cells with each of the inhibitors resulted in a reduced response to LPS as was visualized by a decrease of TNF-α, IL-1, and IFN-γ production. In addition, inhibitors of the NF-κB and SAPK/JNK signaling reduced IL-6 production in LPS-treated cells, whereas the IKK inhibitor XII also decreased IL-10 production. Further, the NO production in LPS-stimulated macrophages was significantly reduced following application of CLI-095 or IKK inhibitor XII. The results also showed that the inhibitors suppressed TLR4 production and decreased phosphorylation of NF-κB and SAPK/JNK proteins, thereby preventing the activation NF-κB and SAPK/JNK signaling pathways in LPS-activated cells. In addition, the production of inducible heat shock proteins, HSP72 and HSP90-α, was reduced in LPS-stimulated RAW 264.7 cells pre-treated with inhibitors. These results suggest that inhibitors CLI-095, SP600125, and IKK inhibitor XII demonstrate potential effectiveness in the reduction of the inflammatory response by mechanisms involving both the cellular defense system and cellular signaling. In conclusion, suppressor of NF-κB cascade, IKK inhibitor XII, seems to be the most effective anti-toxic agent among studied inhibitors.Journal of Immunotoxicology 07/2012; 10(2). DOI:10.3109/1547691X.2012.700652 · 2.05 Impact Factor
Article: Thymic peptides restrain the inflammatory response in mice with experimental autoimmune encephalomyelitis[Show abstract] [Hide abstract]
ABSTRACT: Modulation of autoimmune inflammation by the thymic peptides thymulin and thymopentin was studied in mice with acute experimental autoimmune encephalomyelitis (EAE), which resembles multiple sclerosis in humans. EAE was induced in NZW mice by a single immunisation with myelin basic protein coupled with adjuvants. Visible signs of pathology appeared on days 12-14 after the immunisation, peaked on days 20-25, were retained up to day 45, and then reverted. A biphasic cytokine response was also detected. In the "early" phase, which started at day 35, increased levels of interferon-gamma and interleukin-6 in the blood were observed; during the "delayed" phase, which started at day 48, the levels of plasma interleukin-17 and tumour necrosis factor-alpha were also raised. In addition, the phosphorylation of NF-kappaB signalling proteins and the production of heat shock protein Hsp72 were significantly increased in splenic lymphocytes from EAE-bearing mice. When applied intraperitoneally every other day for 30 days, either thymulin or thymopentin (15μg per 100g of body weight) significantly reduced the disease severity compared to untreated EAE mice. The effect of thymulin but not thymopentin remained after its withdrawal. Thymulin reduced the cytokine response in both the early and the delayed phases, whereas thymopentin only reduced the "early phase cytokines" (IL-6 and interferon-gamma). Both peptides significantly reduced the level of phosphorylation of the NF-kappaB signalling protein IKK and the production of Hsp72 protein. The data presented here indicate the presence of time-dependent immune responses in EAE-bearing mice, which may be associated with the Th1 and Th17 subpopulations of T-cells. Thymulin and thymopentin demonstrated different patterns of activity, most likely via mechanisms involved in NF-kappa B signalling and Hsp72 expression.Immunobiology 05/2012; 218(3). DOI:10.1016/j.imbio.2012.05.023 · 3.04 Impact Factor
Article: Effects of several inhibitors of intracellular signaling on production of cytokines and signal proteins in RAW 264.7 cells cultivated with low dose ammonium[Show abstract] [Hide abstract]
ABSTRACT: Effects of four inhibitors of NF-kappaB, SAPK/JNK and TLR4 signaling, namely, inhibitor XII, SP600125, CLI-095 and Oxpapc on a macrophage response to low dose ammonium were studied in RAW 264.7 cells. Low dose ammonium induced pro-inflammatory response in cells as judged from enhanced production of TNF-alpha, IF-gamma, and IL-6, and by activation of signal cascades. The increase in production of cytokines, namely TNF, IFN, and IL-6, demonstrated that low-dose ammonium induced a pro-inflammatory cellular response. In addition, an activation of NF-kappaB and SAPK/JNK cascades, as well as enhancement of TLR4 expression was shown. Each of used inhibitors reduced to a variable degree the pro-inflammatory response of RAW 264.7 cells on chemical toxin by decreasing cytokine production. The inhibitor of NF-kappaB cascade, IKK Inhibitor XII, was more effective, and not only prevented the development of pro-inflammatory response induced by ammonium, but also decreased cytokine production below control values. The inhibitor of extra cellular domains of TLR2 and TLR4 (OxPAPC) had almost the same anti-inflammatory effect, and an addition of the inhibitor of JNK cascade (SP600125) to cell culture practically neutralized effect of ammonium ions by decreasing cytokine production to control level. Inhibitory analysis showed that activation of RAW 264.7 cells induced by chemical toxin coincide incompletely with intracellular signaling pathways that were early determined regarding macrophage's response to toxin from gram-negative bacteria. Nevertheless, application of the inhibitors defended RAW 264.7 from toxic effect of the low dose ammonium.Biofizika 05/2012; 57(3):437-45. DOI:10.1134/S0006350912030177 · 0.43 Impact Factor
Article: Thymus peptides regulate activity of RAW 264.7 macrophage cells: Inhibitory analysis and a role of signal cascades[Show abstract] [Hide abstract]
ABSTRACT: The aim of this study was to reveal T-lymphocyte-independent mechanisms of thymic peptide-mediated immunomodulation. The effects of two thymic peptides- thymulin and thymopentin were studied in cultured RAW 264.7 macrophages (lipopolysaccharide-stimulated or unstimulated) by measuring cytokine production and signal protein levels. Both peptides increased proinflammatory cytokine secretion by unstimulated RAW 264.7 macrophages and these effects were blocked by the NF-κB cascade inhibitor, stress-activated protein kinase (SAPK)/JNK cascade inhibitor and, to a lesser extent, Toll-like 4 receptor activity inhibitor. In macrophages stimulated by bacterial lipopolysaccharide, peptides alone did not affect cytokine secretion, but significantly enhanced effects of each of the inhibitors. Thymopentin increased activation of both NF-κB and SAPK/JNK cascades in unstimulated macrophages, while thymulin significantly decreased activation of the SAPK/JNK but not NF-κB cascade in LPS-stimulated macrophages. Thymulin and thymopentin increased production of the heat shock protein HSP72 both in LPS-stimulated and unstimulated cells. Thymulin and thymopentin are effective anti-inflammatory modulators with direct actions on innate immune cells; the effects involve multiple signal cascades, including NF-κB and SAPK/JNK pathways. Since signaling cascades are now considered to be targets for new therapies, thymic peptides may be prospective modulators of signaling cascades, acting alone or in combination with other agents.Expert Opinion on Therapeutic Targets 12/2011; 15(12):1337-46. DOI:10.1517/14728222.2011.641952 · 5.14 Impact Factor
Article: Role of heat shock protein Hsp90 in formation of protective reactions in acute toxic stress[Show abstract] [Hide abstract]
ABSTRACT: The involvement of heat shock protein Hsp90 in pro-inflammatory response in male NMRI mice under conditions of acute toxic stress, caused by lipopolysaccharide from Gram negative bacteria, was studied using geldanamycin, a specific blocker of the activity of this protein. It is shown that the introduction of geldanamycin lowers total intoxication of the organism upon acute toxic stress caused by endotoxin. Thus, a decrease in cytokine TNF-alpha, IFN-gamma, IL-1, and IL-10 concentrations in blood serum of the geldanamycin-treated animals with acute toxic stress was found along with normalization of functional activity of nitric oxide producing peritoneal macrophages. Studying expression of receptor protein Tlr-4 as well of proteins of two signal cascades, NF-kappaB and SAPK/JNK, has shown that mechanisms of the geldanamycin protective effect are realized at the level of inhibition of Tlr-4 receptor expression, which provides for endotoxin-to-cell binding, and due to lowering the endotoxin-stimulated activation of signal cascades NF-kappaB and SAPK/JNK. The results suggest Hsp90 might be a therapeutic target in diseases accompanied by acute toxic stress.Biochemistry (Moscow) 06/2010; 75(6):702-7. DOI:10.1134/S0006297910060040 · 1.30 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Effects of three chemical compounds: ammonia, diethyl ether, and acetic acid, known as common environmental contaminants in technogenic accidents, were investigated in vivo and in vitro in low concentrations. When added in cultivation media, each of the chemicals has affected peritoneal macrophages and spleen lymphocytes isolated from male NMRI mice and led to a rise in the production of several cytokines, particularly the tumor necrosis factor-α and interferon-γ, as well as the expression of the inducible form of heat shock proteins (HSP72 and HSP90-α) and in the activation of signal cascades NF-κB and SAPK/JNK. The increase of the nitric oxide (NO) production in macrophages has been observed only when ammonia was added in cultivation media. Also, low concentrations of all compounds investigated led to the activation of the expression of receptor protein TLR4. When mice were exposed to airborne toxic contaminants in a hermetically sealed experimental chamber, an increase in the concentrations of cytokines, heat shock proteins, and signal proteins in immune cells was also observed in response to low concentrations of all chemicals investigated. Similarly to in vitro experiments, the NO production was augmented only in the presence of the airborne ammonia. The results indicate the environmental hazard of chemical contaminants even in rather low concentrations, which nevertheless lead to the stress response. Key wordsammonia-diethyl ether-acetic acid-cytokines-heat shock proteins-NF-κB-SAPK/JNKBiophysics 04/2010; 55(2):317-323. DOI:10.1134/S0006350910020259
Article: Involvement of NF-κB transcription factor in the antiinflammatory activity of thymic peptidesDoklady Biological Sciences 10/2009; 428(1):484-486. DOI:10.1134/S0012496609050263
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ABSTRACT: The effects of mixed dietary coenzyme Q(9), alpha-tocopherol, and beta-carotene on immune cell activity and blood cytokine profile were studied in peritoneal macrophages, spleen lymphocytes, and blood plasma from mice with acute inflammation induced by lipopolysaccharide (LPS). The activity of each fat-soluble antioxidant was also investigated separately in several model systems, both in vivo and in vitro. NMRI male mice were fed a diet supplemented with fat-soluble antioxidants for 15 days prior to LPS injection. LPS-induced inflammation resulted in induction of cellular production of pro-inflammatory cytokines such as TNF-alpha, IL-1alpha, IL-1beta, IL-2, IL-6, IFN-gamma, and also IL-10, an anti-inflammatory cytokine, and subsequent accumulation of these cytokines in blood plasma. In animals fed the antioxidant-rich diet, the inflammatory response to LPS injection was significantly reduced. The production of anti-inflammatory cytokine IL-10 in response to toxic stress and its accumulation in plasma were not modified by the diet. In addition, the expression of the inducible form of heat-shock protein 70 in mice treated with endotoxin was reduced in the animals pretreated with the antioxidant-rich diet. We showed that the diet suppressed phosphorylation of NF-kappaB, I kappaB kinase and SAPK/JNK proteins, thereby preventing the activation of the NF-kappaB kinase and SAPK/JNK signaling pathways in LPS-treated mice. In this report we demonstrate the potential effectiveness of naturally occurring antioxidant nutrients in the reduction of the inflammatory response. Therefore, it may be possible to develop novel therapeutic combinations, containing coenzyme Q(9), alpha-tocopherol, and beta-carotene, which promote immune stimulation.European journal of pharmacology 09/2009; 615(1-3):234-40. DOI:10.1016/j.ejphar.2009.05.004 · 2.53 Impact Factor
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ABSTRACT: The effects of thymopentin, a synthetic analog of the active center of the thymus hormone thymopoietin, on the immune status of mice with two different models of inflammation induced by injection of lipopolysaccharide (LPS) from Gram-negative bacteria were studied. Acute inflammation was induced by a single injection of LPS in a dose of 250 μg/100 g of body weight, and chronic inflammation (sepsis) was modeled by daily injection of LPS for 11 days with a gradual increase in the dose range from 25 to 250 μg/100 g of body weight. Under acute inflammation, a preliminary injection of thymopentin did not induce any additional stimulation of cytokine production increased by LPS. On the contrary, whereas the chronic introduction of LPS was characterized by a depressed production of several cytokines, thymopentin produced an immunostimulating effect. Thus an increase in the production of nitric oxide, interferon-μ, and Hsp70 was demonstrated. In addition, a more effective restoration of the number of thymus cells, as well as an increase in macrophage tumor necrosis factor-α production were observed after cessation of LPS + hormone injections. The results show that preliminary application of thymopentin promotes the regulation of immune cell activity under acute and chronic inflammation.Biophysics 04/2009; 54(2):182-187. DOI:10.1134/S0006350909020122
Article: The role of protein kinase SAPK/JNK in cell responses to low-intensity nonionizing radiation[Show abstract] [Hide abstract]
ABSTRACT: The effect of low-intensity laser light (He-Ne, 0.2 mW/cm2, 632.8 nm, exposure time 1 min) or centimeter waves (8.15–18 GHz, 1 μW/cm2, exposure time 1 h) on Phospho-SAPK/JNK production in mice lymphocytes was investigated. Normal isolated spleen lymphocytes or cells incubated previously with geldanamycin, an inhibitor of Hsp90, were used in the experiments. Significant stimulation of Phospho-SAPK/JNK production in lymphocytes after treatment with laser light or microwaves has been shown in both cell models. It was proposed that activation of the SAPK/JNK signal pathway plays one of the central roles in cellular stress response to low-power nonionizing radiation.Biophysics 04/2009; 54(2):179-181. DOI:10.1134/S0006350909020110
Article: Effect of geldanamycin on expression of signal proteins and heat-shock proteins in normal mouse lymphocytes[Show abstract] [Hide abstract]
ABSTRACT: Effects of geldanamycin (GA), a known inhibitor of the heat shock protein 90 (Hsp90) activity, on the expression of some signal proteins and various heat-shock proteins were studied by Western blot analysis in cultivated spleen lymphocytes isolated from male NMRI mice. It has been revealed that cultivating the cells with GA results in a significant decrease in the amount of transcription factor NF-κB, as well as in its phosphorylated form pNF-κB and the protein suppressing its activity, IκB-α. Furthermore, the presence of GA in the cell-cultivation medium produced a significant decrease in the amount of protein kinase SAPK/JNK. Such a GA-produced modification in the signal protein system suggests the participation of GA in the development of a stress response in an animal cell to damaging action. This suggestion was checked on a model of a cell's stress response to the action of low-intensity laser radiation. It was proven that the Hsp90-binding agent, GA, significantly decreased in vitro the level of the stress response to laser radiation by decreasing the production of heatshock proteins, Hsp70 and Hsp25, both in irradiated isolated lymphocytes and in their intracellular structures. These findings open prospective uses for geldanamycin in various therapies that are accompanied by undesired side effects connected with increased levels of stress response in immune system cells.Cell and Tissue Biology 07/2008; 2(4):366-372. DOI:10.1134/S1990519X08040044
Article: Effect of thymopentin on the production of cytokines, heat shock proteins, and NF-κB signaling proteins[Show abstract] [Hide abstract]
ABSTRACT: In vivo effects of thymopentin, an active fragment of the naturally occurring thymic hormone thymopoietin, on the production of cytokines, nitric oxide, heat shock proteins, and signaling proteins NF-κB, phNF-κB, and IκB-α in lymphoid cells of male NMRI mice was studied. Activation of production of several cytokines (IL-1α, IL-2, IL-6, IL-10, and IFN-γ), nitric oxide, and heat shock proteins (HSP70 and HSP90) was observed in peritoneal macrophages and spleen lymphocytes of mice that received intraperitoneal injections of thymopentin (15μg per 100 g body weight). Thymopentin apparently produces stress-like rather than damaging effects. A probable action mechanism of this hormone is activation of the NF-κB signaling pathway, which is most pronounced at the NF-κB phosphorylation stage.Biology Bulletin 07/2008; 35(4):362-367. DOI:10.1134/S1062359008040055 · 0.25 Impact Factor
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text: Well- I guess I might be the sole voice of dissent here. I've had FAR greater success using (can't speak about amber since I've never used them) but BROWN glass bottles than plastic. I find if you use a good quality chemistry type brown glass bottle and keep it filled to the brim, then your chems can last up to 3x longer... perhaps it's just the plastic I was using was poor grade or something - I don't know. But that's been my experience.


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Literature: Cam Jansen
The Cam Jansen series is a long-running series of children's mysteries, written by David A. Adler, starting in 1980.Cam Jansen is a girl with a perfect photographic memory, which she uses to solve crimes, with the help of her friend Eric Shelton.The books are aimed at kids around the ages of 7-9, despite Cam and Eric being in fifth grade.There are over thirty books in the main series. There is also a Young Cam Jansen series which adds about 15 more.
These books contains examples of:
- Kid Detective: Cam and Eric both try to solve crimes wherever they go.
- Only Known by Their Nickname: Eric and most everyone else calls her Cam, except for her parents (who call her by her real name, Jennifer).
- Photographic Memory: Cam's ability, which helps her solve the crimes.


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She has had: scrambled eggs, broccoli ,carrots, chicken. She loves toast, puffs and Cheerios. I have given her melons and banana. I am not sure about meats.
Try making your own chicken nuggets. My kids, except DS who has sensory issues, all started eating meat like steak when they were about 1, I just cut it up into little chunks so it wasnt to hard for them to "chew". Also try making her chicken salad, they have white chunked chicken meat in a can, like tuna, its really good made up like tuna on a sammy. You could also make her like spaghetti with meat sauce. Or finally try making her some fish sticks or fish fillets.
Momma to ~ DSD19, DD15, DD13 (OCD,ADHD, mood disorder ), DSAngel (T18),DS9 (Autism,Asthma & food allergy ) and Grandma to DGS a 1yr old!
My little guy liked cottage cheese, and still does. It has a lot f protein. She should e able to eat small pieces/mushed up pieces of pretty much whatever you are eating.
So maybe make a goal to try and make 2 homecooked meals per week or something like that? Culd be easy stuff like crockpot meals etc. Meatloaf and meatballs are easy and you could use ground turkey, quiche is another good easy one---especially if she likes eggs.
Mine loves everything. Avocado/steamed or sauteed veggies with sprinkled cheese, plain yogurt/ cottage cheese/ meatballs, chicken/pork/beef (roasted/curried/whatever), meatballs, dry fruits chopped up (dates, figs, raisins, cranberries), fruits esp banana/grapes chopped up/blueberries, cottage cheese, parmesan, pasta with pesto, toast with tapenade or pea pesto/ fish baked or pan fried/rice/couscous etc etc. Basically he eats whatever we eat.
Just try the crockpot or bake meat and chop it up and freeze it in small portions. Fish has to be used soon so canot be frozen.
Mom to a lovely little boy and a gorgeous little girl!
Yay for October Birthdays! My DD will be 1 on the 7th. She pretty much eats anything I make, just mushed up or cut really small. We do lots of fresh fruits and steamed veggies. If I make something that she can't eat (something that's too spicy), then I have noodles in the fridge that I heat up with either EVOO or butter.
*Ashley* Married to the ♥ of my life, Marcus 10/15/06, and Mommy to our princess', Alexis Violet 5/12/09 and Avery Elizabeth 10/07/11.
EPing SAHM to DS Lennon, 10/5/11! First four months were reflux hell, but now I'm having fun with all the smiles and laughs!! - Staci


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A ship I built with parts from the Dathomir Speeder set.
This is Draa, a clone in Gree's squad. Look it up on Wookiepedia if you don't believe me.
Bariss Offee leads her troops into battle while she ties up loose ends.
Ask a question to Rocket, my clone. Results soon!
pic 1:The clone wants the Slurpie, but can't get in it.pic 2:Slurpie paradise!!!!!pic 3:BRAIN FREEZE!!!!!!!
Even though the title sounds like something out of a Twilight novel,it's not.It's my new series!The storyline revolves around a Jedi on the verge of the dark side.Hope you will read it.My first one m …
Hey everybody!I'm making a contest active to any members of my club!Create a scene of the biggest Clone Wars battle you can make possible!Even better,YOU CAN PICK YOUR PRIZE!!!!!Either comments,stars …
It's me bLAmmOOO!But now I am bOOmOOO.Luckily,my club is still on!Create an avatar if you want to be in,and.......bOOmOOO!You're in!P.S:Find the lego werewolf.P.P.S:Have the tag "bOOmOOO".
Spots lef …
Pic 1:Help!!!!
Pic 2:Backup!!!!
Pic 3:Yaaaaaaa!!!!
Pic 4:Noooooo....
Pic 5:Ooooohhh!
It's me!bLAmmOOO!I forgot my password,so now I'm bOOmOOO!Sup' everybody!


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"In Super Natural Cooking, Swanson not only goes a long way toward helping 'whole' foods shed their stale, hippie stigma but also makes a strong case for putting natural foods at the center of an emerging, modern, global cuisine. Her seductive recipes, like lime-bathed peanut salad and an updated (almost guilt-free) take on the classic Girl Scout Thin Mint cookie, reach out to cooks who want to eat smart but still do it in style."
"Super Natural Cooking isn't just any other cookbook; it's meant to inspire and educate, utilizing natural and native ingredients and worldly flavors . . . A great addition to your culinary library as you expand your definition of healthy cooking."
–Healing Lifestyles & Spas
"A good, solid guide to natural foods, ingredients, and how to use them without the stigma of this food being only boring, bland steamed vegetables and tofu. You'll like her style and simple recipes along with some beautiful photos. Simplicity and ease are great assets of this book."
–South Florida Sun-Sentinel
"Looking for new ways to eat more naturally and healthfully? Super Natural Cooking is full of good ways to expand your use of whole and natural ingredients."
–Cincinnati Enquirer
"Super Natural Cooking provides not just recipes and advice, but a new perspective on food and how to eat what you should."
–Baltimore Sun
"At last a cookbook is coming that makes natural food appear glamorous and desirable."
–UPI (United Press International) Eat to Live column
"[T]he book's layout is urbane, the photos lush, the recipes modern and sophisticated. The teff-and-tofu crowd, it seems, has gone high-gloss."
–Houston Chronicle
Photographer, cookbook author, and graphic designer HEIDI SWANSON is the creator of the award-winning culinary websites 101 Cookbooks and Mighty Foods. Her work has been featured on NPR and in national and international pubWashington Post, Vegetarian Times, Time, and Life. She lives in San Francisco.See all Product Description
The book is beautiful! and the recipes are rich in color an nutritional value. I gave it 4 stars in 2007. But now in 2012... Read morePublished on June 24 2013 by Soledad Miranda
I love Heidi Swanson's blog, as well as her cookbooks; her recipes always seem to turn out perfectly and they are consistently delicious, as well as being healthy.Published on June 19 2013 by Samantha April
This book is beautiful and the recipes Delicious!
Everything I cook my family Loves and I get the credit.
Just the way it should be. Read more


text:
This home will be the first home built at Vistas de Plata. Foundation work is currently underway.
Pictured here, from left, are Frank Quarrell, Habitat volunteer; Michele Dwyer, Habitat Construction Manager; Marley Hernandez, Rikki Hernandez, and their father Richard Hernandez, homeowner family; Cissy McAndrew, Habitat President; Patricia Lewis, Jason Allison, April Ortiz and Sheri Thoebald, all with Wells Fargo.
Habitat welcomes community involvement and seeks volunteers for this new home, which will be built to Build Green New Mexico and LEED standards.
For information, or to volunteer, call the Habitat affiliate office, (575) 538-9540, or email firstname.lastname@example.com.


text:
Ex-Bandidos president Adam White is arrested at his Carindale home on Thursday morning. Photo: Queensland Police Service
The former president of the Bandidos Gold Coast chapter has been arrested after allegedly trying to extort $5000 from a man over a fight for a woman.
Adam White, 26, was allegedly acting for a mate when he imposed a $5000 "fine" on a man, police said.
The man was "fined" for contacting his ex-girlfriend who was dating Mr White's friend at the time.
The altercation escalated when the man refused to hand over the cash and four of his friends were allegedly "stamped" with $5000 fines and threatened with violence.
One victim's car windscreen was smashed with a baseball bat during the extortion attempt.
Mr White was arrested on Thursday morning after police, with anti-bikie Taskforce Maxima, raided properties in Brisbane and Logan, including the 26-year-old's Carindale home.
The ex-Bandidos president has been charged with four counts of extortion with circumstance of aggravation under the Newman government's controversial Vicious Lawless Association Disestablishment Act.
Two men aged 22, from Shailer Park and Eight Mile Plains, have also been charged with four counts of extortion with circumstance of aggravation. The duo are alleged members of the Bandidos.
Two other men from Shailer Park, aged 21 and 36, were also arrested during Thursday's raids and charged with possession of dangerous drugs.
The five men are due to face Brisbane Magistrates Court on Thursday morning.
Detective Inspector Brendan Smith of Taskforce Maxima said investigators had identified four victims but were confident more people had been threatened.
He said the extortion investigation, codenamed Operation Mike Groundspeed, further uncovered the true nature of outlaw motorcycle gangs and demonstrated the necessity of the Newman government laws.
"They work together to standover and bully people as a group," Inspector Smith said.
"The actions of these gang members are why the crackdown on criminal gangs is necessary. These offences were committed in public places and targeted everyday Queenslanders, threatening victims with violence for money.
"They have done this as group, using their criminal gang association to further intimidate victims to both comply with their demands, but also to discourage them from complaining to authority.
"Today's results show how the new laws and the ongoing enforcement action are changing things for the better. People now have the confidence to come forward, they are making complaints, they are providing information, and I suspect we will see a lot more of it."
Anyone with information is asked to contact Crime Stoppers on 1800 333 000 or crimestoppers.com.au.


text:
Eric Walter
- Filed Under
Only 28 days after moving into their house in Amityville, N.Y., the Lutz family fled the home, leaving behind all their belongings.
This has been the one undisputed fact in the story which inspired Jay Ansen's 1977 book, "The Amityville Horror," and the subsequent film adaptations. A new documentary directed by Eastern Shore native Eric Walter attempts to re-examine the well-known haunted house story and the subsequent controversy.
"My Amityville Horror" opened in select theaters Friday and recalls the experience of the Lutz family from the perspective of Daniel Lutz, who was 10 years ...


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Frymaster / Dean SR14E DescriptionSKU: 006-SR14E2081
With this Frymaster Super Runner Fryer, you have access to an affordable, high capacity floor model fryer that is ideal for venues that have a high demand for fried menu items. This full size 14-in. x 14-in. fry area can easily accommodate a variety of food sizes, so that you can fry items as small as French fries or as large as fried chicken.
Standard Features and Benefits:
- Frymaster Electric Super Runner Fryer
- Tube-type fry pot design to utilize more oil in each cooking session
- 49-lb. fry pot oil capacity Twin fry baskets gives you access to double the cooking capacity
- Frying area of 13-3/4 in. x 13-3/4 in. (348 x 348 mm)
- Snap-action thermostat to help you keep track of the temperature in your fryer
- Galvanized cabinet
- Wide cold zone reduces oil deterioration by confining debris under the cooking area, preventing oil contamination
- Stainless-steel fry pot, door and backsplash/flue cover with aluminized sides
- Wire form basket hanger
- 6-in. (152 mm) adjustable legs
- Drain pipe extension and a galvanized cabinet
- 6-in. adjustable legs
- 14 kW
Super Runner Electric Value Fryer, 40-lb oil capacity, 13-3/4" x 13-3/4" x 5-1/4" fry area, snap action thermostat, power switch, indicator light, basket hanger, twin baskets, stainless steel frypot, front & door, aluminized sides, 6" steel legs with 1" adjustment, 14 kW, NSF, cULus, CE, 208v/60/1ph
*The warranty will not be honored for residential or non-commercial use of any Commercial Equipment.
Frymaster / Dean SR14E SpecificationsPDF Spec Sheet
|Frymaster / Dean
|Capacity (lbs)
|Number of Fry Pots
|Floor Model
|Width (in)


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Results 1 to 5 of 222
Thread: The New Nameberry
Threaded View
May 7th, 2013 01:25 AM #21
Not sure if this is new or if anyone else is experiencing it, but it shows that I am posting as someone else.I just posted on a question and it said I was another berry. Also the font and color changed did not appear as what I have selected.
Checked again and it showed that everything was normal.If I had an "Autumn" baby...
Juniper Aurelia ◯ Jasper Auberon ◯ Camellia Amber ◯ Phoenix Alder


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Results 11 to 12 of 12
Last edited by FlaGator; 05-27-2011 at 06:34 PM. Reason: Fixed formatFor we are to God the aroma of Christ among those who are being saved and those who are perishing.
To the one we are the smell of death; to the other, the fragrance of life. And who is equal to such a task?
2 Corinthians 2:15-16
|« Previous Thread | Next Thread »


text:
Wire Pieta LyricsArtist: Wire
Popularity : 0 users have visited this page.
Length: 7:29
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Doubting Thomas parks his car in his Sunday best
Taps his wallet, straightens tie, lights a cigarette
Pilgrim's progress, no journey's end
Which way Michael?
Through the door he scans the bar, then a space appears
His drink is poured, for he is numb, the service it starts here
He sees it in the barmaid's face, a winning smile's caress
A million eyes in public stalk, the queue up to confess
Lost causes, loves, hates and shames, old battles fought and won
Bad debts, bad tips, the graveyard song, the dreamers talk in tongues
Haloes swarm, the air is thin, thick smoke in tights of blue
Elvis has a wooden heart, eyes dart across the room
Empty heads and stomachs full, the ashtrays overflow
Drinks are raised and voices praise good deeds of long ago
He drains his glass and makes a sign, the Virgin Queen appears
The Prince King needs a tender touch, his sacred heart knows no fear
Upon a cloud on optic shrine, he can't control his tears
On his knees, hands held in prayer, a practice lapsed for years
The altar clears, the light grows dim, the sanctus bell is rung
A miracle at closing time, our lady holds her son
The faithful come to celebrate the vision Thomas saw
A rail now stands around the spot where Thomas kissed the floor
The hottest lyrics from Wire


text:
If you could not stand your PILs(4 Posts)
PantsInWash Mon 27-May-13 15:55:03
Roastbeefandyorkshires Mon 27-May-13 16:37:20
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Sara was dancing at the stage next to Sol System on Wednesday night. she had bright blue hair. I know she moved from Portland to SF. This isn't some stalker "I need to find this person" kind of thing. I just wanted to say thank you for lightening my mood that night it was greatly needed. I had a lot of shit on my mind. It was nice to see someone dancing as you did and then the quick conversation to lift my heart. Thank you
Jason from Portland


text:
Lennon quits as Celtic coachComment on this story
Neil Lennon quit as manager of Celtic after a successful four years in charge of the Glasgow giants, his agent announced.
Martin Reilly, his agent, said: "Four years is a good spell to be manager of a club like Celtic but now Neil wants to look ahead to the next chapter of his career."
Under Lennon Celtic have won the Scottish title for the past three years.
The 42-year-old former Northern Ireland international was Celtic captain under Gordan Strachan, taking over from Tony Mowbray as boss of the Hoops' in March 2010.
BBC Scotland quoted Lennon as saying: "I have parted company with Celtic. I can't thank Peter Lawwell and the board enough for their backing and support.
"The club are in a very strong position and I wish the fans and the club all the very best for the future."
As well as success in the league Lennon has also helped Celtic claim two Scottish Cup wins and masterminded their run to the last 16 of last season's Champions League.
That European campaign also included the famous Parkhead win over Barcelona and former Leicester midfielder Lennon is now expected to continue his career in England.
But despite being linked with the vacant managerial positions at Norwich and West Brom, Reilly insists his client has not agreed to any job offer yet.
He added: "He has nothing lined up. He just feels now is the time to move on to the next challenge." – AFP
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Hometown Hero: Don Piontek
GREEN BAY, WI. (WFRV) This week's "Hometown Hero". Don Piontek of Green Bay served one year in …
Hometown Heroes: Old Glory Honor Flight 33
WASHINGTON, D.C. (WFRV) This week's "Hometown Heroes" served in during two wars. Others in peace …
Hometown Heroes: D.C. Honor Flight Trip
WASHINGTON, D.C. -- 78 Wisconsin veterans embarked on a long overdue journey to the nation's …
Hometown Hero: Helping Out Our American Heroes
"Helping Out Our American Heroes" is a nation wide organization that brings veterans together to …
Hometown Hero: Reuben Schaetzel
SHAWANO, WI (WFRV) Reuben Schaetzel enlisted in the U.S. Army with his brother in 1943 for service …
Hometown Hero: Jerry Delebreau
Green Bay area man enlisted to get experience and education. Aided humanitarian as well as combat …
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