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Graduate Students
Jonathan Cooper – Cancer Biology
Education: B.S. – Biology, 2010, Dallas Baptist University
Research Interests: Exploring the intersection between cellular growth and renewal signaling pathways and their dysregulation in cancer. Specifically, I am interested in investigating the key players in cellular responses to nutrient availability and probing for selective vulnerabilities in cancers harboring aberrant nutrient sensing.
Cooper, J. M., Bodemann, B. O., and White, M. A. (2013). The RalGEF/Ral pathway: evaluating an intervention opportunity for Ras cancers. The Enzymes 34, 137-157.
Banu Eskiocak – Cancer Biology
Education: D.D.S. – Dentistry, 2007, Cukurova University, Adana, Turkey
Research Interests: Understanding the regulation of proliferation and survival signals in melanoma. As one of the most aggressive tumors, melanoma metastasis to distant organs correlates with less than 9 months of median survival. Molecular heterogeneity in melanoma limits the effectiveness of conventional therapies. This, together with fast development of resistance to next generation drugs, raises the need for additional therapeutic strategies. To help address this need, we are combining genome-wide RNAi screens in metastatic melanoma cell lines with whole genome copy number analyses of human melanoma samples in order to isolate compendiums of gene products responsible for the bypass of normal proliferation and survival restraints during melanomagenesis. Moreover, to be able to develop therapies against these targets, we apply regularized linear regression models that return sparse expression signatures predictive of target sensitivity, which by nature, may serve as molecular response predictors.
Eskiocak, B., Ali, A., and White, M.A. (2014). The Estrogen-Related Receptor alpha Inverse Agonist XCT 790 Is a Nanomolar Mitochondrial Uncoupler. Biochemistry 53, 4839-4846.
Kim, H.S., Mendiratta, S., Kim, J., Pecot, C.V., Larsen, J.E., Zubovych, I., Seo, B.Y., Kim, J., Eskiocak, B., Chung, H., McMillan, E., Wu, S., De Brabander, J., Komurov, K., Toombs, J.E., Wei, S., Peyton, M., Williams, N., Gazdar, A.F., Posner, B.A., Brekken, R.A., Sood, A.K., Deberardinis, R.J., Roth, M.G., Minna, J.D., White, M.A. (2013). Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer. Cell 155, 552-566.
Acharya, A., Baek, S.T., Huang, G., Eskiocak, B., Goetsch, S., Sung, C.Y., Banfi, S., Sauer, M.F., Olsen, G.S., Duffield, J.S., Olson, E.N., Tallquist, M.D. (2012). The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors. Development 139, 2139-2149.
Acharya, A., Baek, S.T., Banfi, S., Eskiocak, B., and Tallquist, M.D. (2011). Efficient inducible Cre-mediated recombination in Tcf21 cell lineages in the heart and kidney. Genesis 49, 870-877.
Mellgren, A.M., Smith, C.L., Olsen, G.S., Eskiocak, B., Zhou, B., Kazi, M.N., Ruiz, F.R., Pu, W.T., and Tallquist, M.D. (2008). Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations. Circulation research 103, 1393-1401.
Ji Mi Kim – Cancer Biology
Education: B.S., 2004, Korea Advanced Institute of Science and Technology (KAIST); M.S., 2007, Seoul National University
Research Interests: Investigating selective dependency of NSCLC cell lines on nuclear transport machinery and unraveling target independent effect of siRNA.
Zhong, R*., Kim, J.*, Kim, H.S., Kim, M., Lum, L., Levine, B., Xiao, G., White, M.A., and Xie, Y. (2014). Computational detection and suppression of sequence-specific off-target phenotypes from whole genome RNAi screens. Nucleic acids research , DOI: 10.1093/nar/gku306 . *Joint First Authours
Kim H, Mendiratta S, Kim J, Pecot C, Larsen J, Zubovych I, Seo B, Kim J, Eskiocak B, Chung H, McMillan E, Wu S, De Brabander J, Komurov K, Toombs J, Wei S, Peyton M, Williams N, Gazdar A, Posner B, Brekken R, Sood A, Deberardinis R, Roth M, Minna M, and White M. A. (2013). Systematic identification of molecular subtype-selective vulnerabilities in non small cell lung cancer. Cell 155: 552-66.
Min J., Choi E.S., Hwang K., Kim J., Sampath S., Venkitaraman A.R., Lee H. (2012), "The breast cancer susceptibility gene BRCA2 is required for the maintenance of telomere homeostasis," J Biol Chem, 287(7):5091-101.
Choi E., Choe H., Min J., Choi J.Y., Kim J., Lee H. (2009), "BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis," EMBO J, 28(14), 1991-3.
Elizabeth McMillan – Cell Regulation with Supplemental Curricula in Computational, Systems Biology
Education: B.A. – Biology, B.A. – Mathematics, 2011, New York University College of Arts and Sciences/New York University Courant Institute of Mathematical Sciences
Research Interests: A major challenge of cancer research is the development of drugs that can target the appropriate population of patients and the segregation of patients into subgroups with the best matched pharmaceuticals so as to maximize efficacy. Non-small cell lung cancer (NSCLC) is the leading cause of cancer related death in the United States, and it currently suffers from a lack of effective pharmaceuticals. In order to identify novel compounds that can be effective in treating NSCLC, we have applied parallel screening of various libraries of chemical compounds in a panel of NSCLC cell lines. These libraries come from both renewable marine natural products as well as purchased form various sources, however, most have unknown mechanism of action. We currently have developed a class of algorithms that use statistical methods to assign enrollment biomarkers to the different classes of pharmaceuticals. These algorithms accomplish two tasks. First, they allow us to fit a mathematical model to each compound, which will enable us to predict sensitivities to each of the compounds in untested cell lines and tumors. In addition, biomarkers that are specifying sensitivity to a compound could hint at a common perturbed upstream or downstream biology in the sensitive versus resistant cells that will then allow us to extrapolate mechanism of action hypotheses for each of the uncharacterized compounds. Experimental validations on both fronts have proven to be successful. Thus, In addition to a rapid mechanism of identifying new effective drugs in NSCLC and drug mechanisms of action, th ese methods will allow us to segregate patients into groups based on their biomarker status to allow us to assign the best matched drug that will be effective in treating that person's cancer.
Ekas, L. A., T. J. Cardozo, M. S. Flaherty, E. A. McMillan, F. C. Gonsalves and E. A. Bach (2010). "Characterization of a dominant-active STAT that promotes tumorigenesis in Drosophila." Dev Biol 344(2): 621-636.
Kim, H. S., S. Mendiratta, J. Kim, C. V. Pecot, J. E. Larsen, I. Zubovych, B. Y. Seo, J. Kim, B. Eskiocak, H. Chung, E. McMillan, S. Wu, J. De Brabander, K. Komurov, J. E. Toombs, S. Wei, M. Peyton, N. Williams, A. F. Gazdar, B. A. Posner, R. A. Brekken, A. K. Sood, R. J. Deberardinis, M. G. Roth, J. D. Minna and M. A. White (2013). "Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer." Cell 155(3): 552-566.
Osborne, J. K., M. L. Guerra, J. X. Gonzales, E. A. McMillan, J. D. Minna and M. H. Cobb (2014). "NeuroD1 mediates nicotine-induced migration and invasion via regulation of the nicotinic acetylcholine receptor subunits in a subset of neural and neuroendocrine carcinomas." Mol Biol Cell 25(11): 1782-1792
Borkowski, R., Du, L., Zhao, Z., McMillan, E., Kosti, A., Yang, C., Suraokar, M., Wistuba, I., Gazdar, A., Minna, J., White, M.A.* and Pertsemlidis, A.*. 2014. Genetic mutation of p53 and suppression of the miR17~92 cluster are synthetic lethal in non-small cell lung cancer due to upregulation of vitamin D signaling. Cancer Research in press. *co-corresponding authors.
Witkiewicz, A.K., McMillan, E.A., Balaji, U., Baek, H., Lin, W., Mansour, J., Mollaee, M., Wagner, K., Koduru, P., Yopp, A., Choti, M., Yeo, C.J., McCue, P., White, M.A., and Knudsen, E.S. 2015. Whole exome sequencing of pancreatic ductal adenocarcinoma reveals hallmarks of disease etiology, prognosis, and targets for therapeutic intervention. Nature Communications 6:6744.
Potts, M.B., McMillan, E.A., Rosales, T. I., Kim, H.S., Ou, Y.H., Tooms, J.E., Brekken, R.A., Minden, M.D., MacMillan, J.B., and White, M.A. 2015. Exceptional responders to dedemnin B illuminate the mechanism of action and pharmacogenomics biomarkers for antineoplastic activity. Nature Chemical Biology
Chensu Wang – Biomedical Engineering
Education: B.S. – Biomedical Engineering, 2011, Southeast University, Nanjing, China
Research Interests: The interface between engineering and biology; in particular the design and development of nanotechnology tools that illuminate dynamic cell biological processes in space and time. My current project is the application of novel pH-responsive nanoprobes for analysis of autophagosome biogenesis at single organelle resolution. (Joint student with Professor Jinming Gao)
Aubhishek Zaman– Cancer Biology
Education: M.S. – Genetic Engineering and Biotechnology, University of Dhaka, Bangladesh
Research Interests: Cancer therapeutics and its mode of actions; key players in cellular growth, vesicular traffic and cellular responses to nutrient availability,.
Publications (selected):
Zaman A* and Razzaque S 'Designing Novel Antibacterials: Application of Omics Science' Klimik Dergisi. 2013; 26; 2-8
Islam MR, Zaman A, Jahan I, Chakravorty R, Chakraborty S*. 'In silico QSAR analysis of quercetin reveals its potential as therapeutic drug for Alzheimer's disease.'J Young Pharm. 2013 Dec;5(4):173-9.
Islam MR*, Hosen MI, Zaman A, Islam MO. 'Structural, functional and molecular docking study to characterize GMI1 from Arabidopsis thaliana.' Interdiscip Sci. 2013 Mar;5(1):13-22.
Zaman A*, Rahaman MH, Razzaque S. 'Kaposi's sarcoma: a computational approach through protein-protein interaction and gene regulatory networks analysis.' Virus Genes. 2013 Apr;46(2):242-54. doi: 10.1007/s11262-012-0865-z. Epub 2012 Dec 25.
Zaman A*, Fancy NN. 'A computational prediction of structure and function of novel homologue of Arabidopsis thaliana Vps51/Vps67 subunit in Corchorus olitorius.' Interdiscip Sci. 2012 Dec;4(4):256-67.
Zaman A*. 'Docking studies and network analyses reveal capacity of compounds from Kandelia rheedii to strengthen cellular immunity by interacting with host proteins during tuberculosis infection.' Bioinformation. 2012;8(21):1012-20.
Islam R, Sakib M S, and Zaman A* 'A Computational Assay to Design an Epitope-based Peptide Vaccine against Chikungunya Virus.' Future Virology. 2012; 7 (10):1029–1042.
Zaman A* (2012) 'Characterization of Coilin protein nucleotide binding region in Homo sapiens' Online Journal of Bioinformatics, 13(2):314-330.
Zaman A* 'Drug Designing Approaches Using In-Silico Techniques' Lambert Academic Press (LAP). 2012; ISBN: 978-3-659-15283-2
*Corresponding author
Postdoctoral Fellows
Hua Gao, Ph.D. – Intervention Targets (Non-small Cell Lung Cancer)
Education: B.S. – Biochemistry, 1999, Xiamen University, China; Ph.D. – Biochemistry and Molecular Biology, 2008, Baylor College of Medicine; Postdoctoral Fellow, 2008-2011, UT Southwestern
Research Interests: Isolating oncogenotype-linked intervention targets against lung cancer, specifically, non-small cell lung cancer (NSCLC). The heterogeneous response of patients to available therapies, and the bottlenecks to development of direct chemical inhibitors of many oncogenic protein variants in tumors, indicates that attention to pharmaceutically addressable wild-type proteins that support tumorigenic activities is warranted. I am employing genetic and biochemical approaches to identify such proteins.
Hua, G., Tasha B. TORO, Margherita PASCHINI, Bari Braunstein-Ballew, Rachel B. CERVANTES and Victoria LUNDBLAD,"Telomerase recruitment in Saccharomyces cerevisiae is not dependent on Tel1-mediated phosphorylation of Cdc13," Genetics, 2010, 186(4): 1147-1159.
Hua, G., Rachel B CERVANTES, Edward K MANDELL, Joel H OTERO, Victoria LUNDBLAD,"RPA-like proteins mediate yeast telomere function," Nature Structural & Molecular Biology, 2007, 14(3): 208-214.
Malia B. Potts, Ph.D. – Cancer Biology
Education: B.S. – Biology, 2001, Duke University; Ph.D. – Genetics and Development, 2008, UT Southwestern
Research Interests: Three aspects of cancer biology: 1) how miRNA's act as tumor suppressors in breast cancer and colon cancer; 2) the signaling pathways that regulate autophagy; and 3) identification of marine natural products with potential as cancer therapeutics.
Potts, M.B., McMillan, E.A., Rosales, T. I., Kim, H.S., Ou, Y.H., Tooms, J.E., Brekken, R.A., Minden, M.D., MacMillan, J.B., and White, M.A. (2015). Exceptional responders to dedemnin B illuminate the mechanism of action and pharmacogenomics biomarkers for antineoplastic activity. Nature Chemical Biology
Shields, B.B., Pecot, C.V., Potts, M.B., Nagel, C., Purinton, S., Wang, Y., Ivan, C., Kim, H.S., Borkowski, R., Kahn, S., Rodriguez-Aguayo, C., Lopez-Berestein, G., Lea, J., Gazdar, A., Baggerly, K.A., Sood, A.K., and White, M.A. (2014). MicroRNA induction of fatal differentiation programs is a common vulnerability in ovarian cancer, in revision.
Potts, M.B., Kim, H.S., Fisher, K.W., Hu, Y., Carrasco, Y., Bulut, G.B., Ou, Y.-H., Herrera-Herrera, M.L., Cubillos, F., Mendiratta, S., Xiao, G., Hofree, M., Ideker, T., Xie, Y., Huang, L.J.-S., Lewis, R.E., MacMillan, J.B., and White, M.A. (2013). Using Functional Signature Ontology (FUSION) to identify mechanisms of action for natural products. Sci. Signal., 6(297), ra90.
*Hu, Y., *Potts, M.B., Colosimo, D., Herrera-Herrera, M.L., Legako, A.G., Yousufuddin, M., White, M.A., and MacMillan, J.B. (2013). Discoipyrroles A-D: Isolation, structure determination, and synthesis of potent migration inhibitors from Bacillus hunanensis. J. Am. Chem. Soc. 135(36), 13387-92. *Equal contribution.
Potts, M.B. and Cameron, S. (2011), "Cell lineage and cell death: Caenorhabditis elegans and cancer research," Nat. Rev. Cancer 11(1), 50-8.
Potts, M.B., Wang, D.P., and Cameron, S. (2009), "Trithorax, Hox, and TALE-class homeodomain proteins ensure cell survival through repression of the BH3-only gene egl-1," Dev. Biol. 329(2), 374-85.
Liu, H., Strauss, T.J., Potts, M.B., and Cameron, S. (2006), "Direct regulation of egl-1 and of programmed cell death by the Hox protein MAB-5 and by CEH-20, a C. elegans homolog of Pbx1," Development 133(4), 641-50.
Potts, M.B., Vaughn, A.E., McDonough, H., Patterson, C., and Deshmukh, M. (2005), "Reduced Apaf-1 levels in cardiomyocytes engage strict regulation of apoptosis by endogenous XIAP," J. Cell Biol. 171(6), 925-30.
Deming, P.B., Schafer, Z.T., Tashker, J.S., Potts, M.B., Deshmukh, M., and Kornbluth, S. (2004), "BCR-Abl-mediated protection from apoptosis downstream of mitochondrial cytochrome c release," Mol. Cell Biol. 23, 10289-99.
Potts P.R., Singh S., Knezek M., Thompson, C.B., and Deshmukh, M. (2003), "Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis," J. Cell Biol. 163(4), 789-799.
Martin Dietrich - Cancer Biology
Education: M.D. – Medicine 2006, University of Heidelberg; Ph.D. – Genetics 2006, University of Heidelberg; Ph.D. – Molecular Biology 2010, UT Southwestern
Research Interest: My research interest is in the field of personalized approaches for lung cancer. The identification of ALK rearrangements and EGFR mutations changed the landscape for a subset of patients. However, the vast majority of lung cancer patient still does not benefit from this progress and undergo conventional chemotherapy. Like a fingerprint, each lung cancer provides its own unique signature of molecular changes. My work at the bench and in clinic focuses on identifying and exploiting genetic vulnerabilities of thoracic malignancies, in particular cancers of the lung. Currently, most clinical trials that substantiate our clinical treatment are a "one size fits all" approach, with little understanding about which patients will actually benefit from chemotherapy treatment. My greater goal is to understand the individual tumor biology, taking into account genetic, epigenetic and metabolic changes, and providing patients with personalized treatment strategies.
Kidd S, Spaeth E, Dembinski JL, Dietrich M, Watson K, Klopp A, et al. Direct evidence of mesenchymal stem cell tropism for tumor and wounding microenvironments using in vivo bioluminescent imaging. Stem Cells. 2009 Oct;27(10):2614-23.
Carter BZ, Mak DH, Schober WD, Dietrich MF, Pinilla C, Vassilev LT, et al. Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5. Blood. 2008 Apr 1;111(7):3742-50.
Ling X, Konopleva M, Zeng Z, Ruvolo V, Stephens LC, Schober W, et al. The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 signaling. Cancer Res. 2007 May 1;67(9):4210-8.
Ling X, Wang Y, Dietrich MF, Andreeff M, Arlinghaus RB. Vaccination with leukemia cells expressing cell-surface-associated GM-CSF blocks leukemia induction in immunocompetent mice. Oncogene. 2006 Jul 27;25(32):4483-90.
Konopleva M, Contractor R, Tsao T, Samudio I, Ruvolo PP, Kitada S, et al. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell. 2006 Nov;10(5):375-88.
Kidd S, Caldwell L, Dietrich M, Samudio I, Spaeth EL, Watson K, et al. Mesenchymal stromal cells alone or expressing interferon-beta suppress pancreatic tumors in vivo, an effect countered by antiinflammatory treatment. Cytotherapy. Sep;12(5):615-25.
Dietrich MF, Karner CM, Johnson EB, Kappesser N, Tennert C, Percin F, et al. Lrp4 regulates initiation of ureteric budding and is crucial for kidney formation--a mouse model for Cenani-Lenz syndrome. PLoS One.5(4):e10418.
Dietrich MF, van der Weyden L, Prosser HM, Bradley A, Herz J, Adams DJ. Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo. PLoS One.5(4):e9960.
Dieckmann M, Dietrich MF, Herz J. Lipoprotein receptors--an evolutionarily ancient multifunctional receptor family. Biol Chem. Nov;391(11):1341-63
Christopher DeSevo
Education: B.S – Biochemistry 2006, Rowan University; Ph.D – Cancer Biology, 2013, UT Southwestern.
Research interest: miRNA have profound regulatory effects as demonstrated by their down regulation in cancerous tissue and ability to regulate the hallmarks of cancer. As such, my graduate work focused on the direct and indirect regulation of miR-10a regulation of the PI3K/AKT/GAT6 pathway, cancer stem cell maintenance and drug resistance in non-small cell lung cancer under the guidance of Dr. John Minna. After receiving my PhD, I was in search of a postdoctoral fellowship in a laboratory that focused on large data acquisition and interpretation. After several interviews at laboratories around the country I chose to stay at UTSW and join the laboratory of Dr. Michael White.
As a therapeutic tool, miRNA offer the advantage of targeting multiple genes and processes in a cancerous cell while having minimal effect on normal tissue. As such, we have identified genotype-specific vulnerabilities of over 50 Lung, Breast, and Colon cancer cell lines screened with genome wide miRNA mimic libraries. Yet, while progress has been made in an attempt to bring oligonucleotide-based therapies to the clinic, issues with delivery and bioavailability hamper widespread clinical application. To circumvent these issues, we have developed Functional Signature Ontology, FuSiOn. FuSiOn maps effect of perturbagens to a 13-reporter gene set that are capable of producing a genetic fingerprint.
Natural compounds are a rich and diverse source of bioactive compounds that can have potent antitumor activity. Yet the mechanism of action can be difficult, time-consuming and costly to discern. With this training grant, we will use FuSiOn to cluster gene signature to quickly elucidate mechanism of action and targets of natural products with similar effects of endogenous miRNA expediting bench side discoveries to clinical application.
DeSevo C, Du L, Behrens C, Wistuba II, Minna JD, Pertsemlidis A. (2013). miR-10a Regulation of the PI3K Pathway Through Direct and Indirect Mechanism in Non-Small Cell Lung Cancer. (In preparation)
DeSevo C, Shao C, Larsen J, Minna JD, Pertsemlidis A. (2013). miR-10a Regulation of Cancer Stem Cells Through Modulation of the WNT Pathway in Non-Small Cell Lung Cancer. (In preparation)
Caudy AA, Guan Y, Jia Y, Hansen C, Desevo C, et al. (2013)Saccharomyces bayanus, a New System for Comparative Functional Genomics. Genetics113 (1): e152918
Du L, Subauste MC, DeSevo C, Zhao Z, Baker M, Borkowski R, Schageman J, Greer R, Yang C, Suraokar M, Wistuba I, Gazdar A, Minna J, Pertsemlidis A. (2012) miR-337-3p and Its Targets STAT3 and RAP1A Modulate Taxane Sensitivity in Non-Small Cell Lung Cancers. PLoS ONE 7(6): e39167.
Calahan D, Dunham M, DeSevo C, Koshland D. (2011) Genetic Analysis of Desiccation Tolerance in Saccharomyces cerevisiae. Genetics 180(2):507-519
Martin O, DeSevo C, Guo B, Koshland D, Dunham M, Zheng Y. (2009) Telomere Behavior in a Hybrid yYast. Cell Research 19(7):910-2.
Gresham D, Desai M, Tucker C, Jenq H, Pai D, Ward A, DeSevo C, Botstein D, Dunham M. (2008) The Repertoire and Dynamics of Evolutionary Adaptations to Controlled Nutrient-Limited Environments in Yeast. PLoS Genet. 4(12):e1000303.
Rachel Vaden
Education: B.S. – Chemistry, 2008, University of West Georgia; PhD – Chemistry, 2015, University of Utah
Research interest: The use of molecular tools to probe biological systems can provide insight into complex cellular processes and disease states. My research is focused on understanding how genetic mutations acquired during tumor progression can confer sensitivity to novel bioactive compounds. Not only can these studies facilitate clinical therapeutic development by identifying patient populations that are likely to be sensitive a specific treatment, but they can also provide direct mechanistic information about cancer signaling pathways that may be used to inform additional treatment design strategies.
Vaden RM, Gligorich KM, Jana R, Sigman MS, & Welm BE (2014) The small molecule C-6 is selectively cytotoxic against breast cancer cells and its biological action is characterized by mitochondrial defects and endoplasmic reticulum stress. Breast Cancer Res 16(6):472.
Gligorich KM*, Vaden RM*, Shelton DN, Wang G, Matsen CB, Looper RE, Sigman, MS, & Welm BE (2013) Development of a screen to identify selective small molecules active against patient-derived metastatic and chemoresistant breast cancer cells. Breast Cancer Res 15(4):R58.
Pathak TP, Osiak JG, Vaden RM, Welm BE, Sigman MS (2012) Synthesis and Preliminary Biological Study of Bisindolylmethanes Accessed by an Acid-Catalyzed Hydroarylation of Vinylindoles. Tetrahedron 68(26):5203.
Researchers / Staff
Kiran Kaur, Ph.D. – Adjunct Instructor / Lab Manager
Education: M.S., 1982, University of Kentucky; Ph.D. 1994, Southern Methodist University
Saurabh Mendiratta – Research Scientist
Education: M.S. – Biotechnology, 2003, MS University, Baroda, India; M.S. – Cell and Molecular Biology, 2006, University of Texas at Dallas
Research Interests: High throughput SiRNA and chemical compound screening to identify gene targets selectively required for cancer cell survival.
Kim, H. S., Mendiratta S., J. Kim, C. V. Pecot, J. E. Larsen, I. Zubovych, B. Y. Seo, J. Kim, B. Eskiocak, H. Chung, E. McMillan, S. Wu, J. De Brabander, K. Komurov, J. E. Toombs, S. Wei, M. Peyton, N. Williams, A. F. Gazdar, B. A. Posner, R. A. Brekken, A. K. Sood, R. J. Deberardinis, M. G. Roth, J. D. Minna and M. A. White (2013). "Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer." Cell 155(3): 552-566.
Potts, M.B., Kim, H.S., Fisher, K.W., Hu, Y., Carrasco, Y., Bulut, G.B., Ou, Y.-H., Herrera-Herrera, M.L., Cubillos, F., Mendiratta, S., Xiao, G., Hofree, M., Ideker, T., Xie, Y., Huang, L.J.-S., Lewis, R.E., MacMillan, J.B., and White, M.A. (2013). Using Functional Signature Ontology (FUSION) to identify mechanisms of action for natural products. Sci. Signal., 6(297), ra90.
Ward S.E., Kim H.S., Komurov K. Mendiratta S., Tsai P.L, Schmolke M., Satterly N., Manicassamy B., Forst C.V., Roth M.G., García-Sastre A., Blazewska K.M., McKenna C.E., Fontoura B.M., White M.A., "Host Modulators of H1N1 Cytopathogenicity," PLoS One, 2012;7(8):e39284. Epub 2012 Aug 2.
Goldsmith E.J., Mendiratta S., Akella R., Dahlgren K., "Natural language query in the biochemistry and molecular biology domains based on cognition search™," Summit on Translat Bioinforma, 2009 Mar 1;2009:32-7.
Tracy Rosales - Research Technician II
Education: B.S. - Biology, University of Texas at Dallas
Research Interests: Understanding the effects of didemnin B, a potential anticancer drug isolated from marine species Trididemnum solidum, on autophagy-regulating pathways.
Potts, M.B., McMillan, E.A., Rosales, T. I., Kim, H.S., Ou, Y.H., Tooms, J.E., Brekken, R.A., Minden, M.D., MacMillan, J.B., and White, M.A. 2015. Exceptional responders to dedemnin B illuminate the mechanism of action and pharmacogenomics biomarkers for antineoplastic activity. Nature Chemical Biology
Jean René Clemenceau - Research Technician II
Education: B.S. - Informatics, 2013, Baylor University
Role: I develop and mantain user interfaces for the data produced, gathered, and used by the lab and fellow contributors to the different current projects. I strive to create user friendly tools that can increase the efficiency of drug discovery from massive amounts of data.
Principal Investigator
Michael A. White, Ph.D. – Professor, Cell Biology
Grant A. Dove Chair for Research in Oncology
The Sherry Wigley Crow Cancer Research Endowed Chair in Honor of Robert Lewis Kirby, M.D.
Education: University of Iowa (1986), Undergraduate; University of North Carolina at Chapel Hill (1992), Graduate
Research Interests: Cancer, molecular architecture of growth regulatory signal transduction cascades, oncogenes, signal transduction and tumor suppressors
Publications: 1992 – 2015


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Justin Bieber Vegas Concert Pic
Also, all you cooks that think it's funny when JB got sick on stage, your Sick! Let me remind you Jimi Hendrix chocked on his vomit and died. Not so funny is it? Steevo
- Photo Credit:
- Judy Eddy/WENN.com
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- Justin Bieber in Las Vegas
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- Justin Bieber
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Welcome to J.R. Crickets
The Beginning of the Buffalo Wing to Atlanta
The Original J.R. Crickets® opened February 1982 on Spring St in Midtown Atlanta Georgia. Over 30 years and 60 million wings later…The Original J.R. Crickets is still slingin' wings in Midtown Atlanta! In December of 2103 a fire moved us to our current location on North Avenue, just three blocks from our previous home. Since then we've only gotten bigger and better than ever. You know all about our wings, but don't forget about our authentic steak & cheese philly, tender bbq pork ribs, juicy burgers and suculent seafood.
A lively bar and inviting outdoor patio make The Original J.R. Crickets® your first choice for great food and fun and always at a great price!
Original Buffalo Wings Sauce, Buffalo BBQ and Southern Sweet Style BBQ Sauces including our Lemony Pepper Seasoning are available at your neighborhood J.R. Crickets® location.
J.R. Crickets Enterprises, Inc. handles our License Program that allows you to open you own and operate a J.R. Crickets® restaurant.
So check us out just like your parents did when they were cool.


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"The only real problem with this card was trying to decide which design to use. The quality of the paper is very nice. It feels and looks expensive. Very easy to use as well. I love using Tiny Prints."


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The hit A&E series CRISS ANGEL MINDFREAK® stretches the boundaries of reality and belief in each thrilling episode as world-renowned mystifier Criss Angel executes incredible illusions, death-defying escapes, fearless demonstrations and astonishing physical feats. The first ever five-time back-to-back recipient of the Magician of the Year award, Criss Angel has performed more magic on television than any other magician in history.
Angel's visionary approach to the art of magic has astonished fans in past seasons when he hung suspended by hooks over a desert and split a woman in a public park in two. In the fifth season Angel performed all new mind-bending feats, including walking through a minefield, levitating a crowd of spectators and being buried alive beneath several tons of wet, heavy snow.
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Pushing creative, physical and mental boundaries, magician and illusionist Criss Angel has been hailed as the 21st Century Houdini. On A&E's show, Criss Angel Mindfreak, Angel boggles the mind with death defying escapes whether he's floating above the Las Vegas Luxor or levitating over ordinary people's television sets. Shop for Criss Angel DVDs at the A&E Store and you'll find seasons one through six, including magician kits and memorabilia.
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In this show, the Mindfreak demonstrates how magic has kept the kid alive in him. Criss turns a young girl's toy Barbie into a real women, then physically transforms himself back into a child again.
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MensTennisForums.com (http://www.menstennisforums.com/forumindex.php)
- General Messages (http://www.menstennisforums.com/2-general-messages/)
- - Kei Nishikori: Your Expectations for 2013 (http://www.menstennisforums.com/2-general-messages/213960-kei-nishikori-your-expectations-2013-a.html)
Kei Nishikori: Your Expectations for 2013
Kei had an injury marred 2012 but still had a very decent year, with QFs in Australia and Olympics and his first 500 title in Tokyo, and some very good wins. 2013 should be much better from one of the most promising, if not the most promising, young talents around. What do you guys expect from Kei?
First of all, I expect him to play a full season healthy, which would already be breaking new ground and would allow him to make big strides. I also expect him to make steady improvements on his game, namely his serve and defensive shotmaking, which are the two areas he most needs to improve.
At AO, a #19 seed isn't ideal, but I'd expect him to reach at least round 4 beating a 9-16 seed in round 3 and maybe repeat a QF showing if he draws Ferrer, Tsonga or Berdych in R4.
The North American swing and especially the clay season were a write off for Kei last season, plagued with injuries - he had so skip Rome, Madrid and RG and wasn't in top form for the other events. This year, I'd expect solid showing in IW and Miami and a solid clay season too - he has shown that he can play on clay. I hope he can build up his ranking during this stretch so he can enjoy some better draws in the second half of the season on grass and North American hardcourts. Getting as high as #12 would really help as he'd be facing Berdych, Tsonga and Ferrer in the lst 16 of events, opponents he definitely likes to face.
I expect him to play well on all surfaces and win 2 or 3 titles at the 250 and 500 level and to do well at Masters and Slams too. Making a first Slam semi might be too big a breakthrough for 2013 (although it's not out of the question with a good draw), but a couple of QF showings should be achievable. He should reach the top 10 with a decent chance of making it to the O2 with a strong end of the season and position himself to be a stronger contender in 2014. Much will depend on how long he takes to make it to the top 12, since a top 12 seed will help him with draws tremendously.
Re: Kei Nishikori: Your Expectations for 2013
I expect a broadly similar season to last but with a bit more consistency and one extra small title.
similar in injury terms as well but if he can stay fully fit all year (which I don't expect) then I wouldn't be surprised to see him finish in the 9-12 range.
gun to head year end ranking: 13
Re: Kei Nishikori: Your Expectations for 2013
He will call for the trainer the most out of any player on tour. Will still be overrated.
Will finish between 15-20 barring major injuries.
Re: Kei Nishikori: Your Expectations for 2013
Re: Kei Nishikori: Your Expectations for 2013
I think Kei was a bit unlucky in the Slams in 2012:
AO - he did very well to reach QF but played far too many marathons and was exhausted to face Murray.
FO - Was injured, had to withdraw.
W - drew Del Potro in round 3, JMDP is probably his worst matchup on tour.
USO - faced an on-fire Cilic in round 3, the same Cilic who was crushing Murray for almost 2 sets before completely imploding. He actually didn't play badly at all vs Marin, Cilic just overwhelmed him.
He should look to build up his ranking during the first part of the year to avoid running into such hard opponents so early on and have a better chance to make great runs. 9-12 range is entirely possible with a good clay season since he has nothing to defend from last year.
Re: Kei Nishikori: Your Expectations for 2013
Kei will finish 2013 inside the Top 10. He'll be more consistent than in 2012, and the numbers of haters he has will grow exponentially. But he'll still finish the season like this:
Re: Kei Nishikori: Your Expectations for 2013
Kei having a fit full season? Dream on.
Re: Kei Nishikori: Your Expectations for 2013
If he manages to stay healthy, then i predict a top 10 finish, or just outside the top 10.
Re: Kei Nishikori: Your Expectations for 2013
Re: Kei Nishikori: Your Expectations for 2013
Re: Kei Nishikori: Your Expectations for 2013
Do different colour Sabers, mean different things?
Or is it just random?
Re: Kei Nishikori: Your Expectations for 2013
Mostly what's here. It all corresponds to my view on the player's style of play, so many people may have different views, although I think I lean with the majority. I find Kei's style baseline with variation and an inch on net play, with a rather weak service game. White would be his color, but I combined it with samurai colors (making it all black and white) to make him unique. I did that to many of the players in my signature.
Kei will hardly be a number 1, so, the "final product" for my signature will probably never be made.:D
Re: Kei Nishikori: Your Expectations for 2013
Ah, i see. :yeah:
I thought it had something to do with style, but i wasn't sure.
Re: Kei Nishikori: Your Expectations for 2013
As for haters, you know you're doing something right when one of them is Action Jackson :yeah:
Re: Kei Nishikori: Your Expectations for 2013
Top 10. Full uninterrupted season. At least one slam Semi. One Masters title.
I'm probably being incredibly biased as a fan of his, but this is as sensible as I can get with predicting Kei.
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Mojokerto Things to Do
Relaxation, off roader, natural...
Relaxation at Ubalan - Pacet with some fresh air, or take natural hotspring water at the cozy place around Pacet. See rain forest at Trawas and Cangar for off road adventure! Explore the ancient Mojopahit kingdom temples. All you can see at Mojokerto!!Related to:
- Archeology
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Mojokerto Transportation
Bus from SURABAYA- Bungurasih to...
How to get to MOJOKERTO and TROWULAN: The first, take a bus with the destination to MOJOKERTO at SURABAYA - BUNGURASIH bus station, its about 50 km southwestward and would take about one hour and cost Rp 5,000, -
The bus will stop at Mojokerto Bus station, then take a mini van popular with "angkot" (public transportation), ask the driver that you would visit many temples in trowulan and bargaining the the cost. As my experience, the driver agree to take me to Wringin Lawang, Bajang Ratu, Candi Tikus, Archeology Museum, Pura Segara, Buddha statue, King Brawijaya cemetery, Candi Brahu and return back to Mojokerto Bus terminal and I was just paid the driver Rp 100,000 for the tripsRelated to:
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|ISSN 1088-6826(online) ISSN 0002-9939(print)
Spaces on which every pointwise convergent series of continuous functions converges pseudo-normally
Abstract | References | Similar Articles | Additional Information
Abstract: A topological space is a -space provided that, for every sequence of continuous functions from to , if the series converges pointwise, then it converges pseudo-normally. We show that every regular Lindelöf -space has the Rothberger property. We also construct, under the continuum hypothesis, a -subset of of cardinality continuum.
Retrieve articles in Proceedings of the American Mathematical Society with MSC (2000): 54G99, 03E35, 54A35, 54C30
Retrieve articles in all journals with MSC (2000): 54G99, 03E35, 54A35, 54C30
Additional Information


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I have decided to go back and run through all of the Main Series Pokemon games that I have. I am not cheating and I am recording the in-game time from start to Hall of Fame entry and then recording my team. I also have a few self-imposed rules;
1) I cannot have the same Pokemon on 2 Hall of Fame teams from the same generation. Except when limited by Rule 3 (see Generation 5).
2) Hall of Fame teams must consist of 6 Pokemon from the native region.
3) My Starter Pokemon must be in the Hall of Fame team.
4) No more than 1 Legendary Pokemon per Hall of Fame team.


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This content has been marked as final. Show 2 replies
1. Re: How to update product information without overwriting all informationErick - BCGurus.com May 18, 2012 4:16 PM (in response to Klinkoz)
Yeah there isn't a way to do that.
2. Re: How to update product information without overwriting all informationKlinkoz May 21, 2012 8:29 AM (in response to Erick - BCGurus.com)
If this isn't posible than what is the use of the updateinsert function?
It would be a real flaw if this isn't possible.
Does anyone else have a suggestion? Or do i have to tell my client that he has to switch webshops, would be a real shame.


text:
About Jeff Masters
Dr. Masters co-founded wunderground in 1995. He flew with the NOAA Hurricane Hunters from 1986-1990. Co-blogging with him: Bob Henson, @bhensonweather
By: Dr. Jeff Masters , 1:54 PM GMT on August 31, 2006
Tropical Storm Ernesto is gathering strength, headed for a landfall near the North Carolina/South Carolina border late this afternoon. Radar animations from the Charleston radar shows a steadily organizing system, with a strong band of heavy rain wrapping around the west side of the center. Ernesto may have a partial eyewall and be a strong tropical storm with 65-70 mph winds at landfall. Wind observations from offshore buoys have been as high as 30 mph sustatined with gusts to 42 mph this morning. The Hurricane Hunters left the storm at 6am EDT this morning, and reported a pressure of 996 mb before they left. This is not far from Ernesto's 990 mb pressure it had when it was a hurricane with 75 mph winds south of Haiti. A NOAA Hurricane Hunter is due in the storm by noon, and an Air Force airplane at 2pm EDT.
Figure 1. Current long-range radar out of Charleston.
The north side of Ernesto is under some significant wind shear of 20 knots, thanks to southwesterly upper-level winds from the trough of low pressure pulling the storm to the north. As Ernesto moves further north, the shear will increase, likely putting a limit on the amount of intensification the storm can do. Water temperatures under the storm are about 30 C, which is very favorable for intensification. The eastern portion of the storm is over the axis of the very warm Gulf Stream Current.
Hurricane John
Hurricane John is a dangerous Category 3 hurricane this morning, just 100 miles off the coast of Mexico. The storm is moving parallel to the coast, but any deviation to the right would bring the intense core to the coast, making it one of the strongest Pacific hurricanes ever to strike Mexico. The forecast track of the storm takes it very near to the tip of the Baja Peninsula, so John has a chance to make a double hit on Mexico. John could be the strongest hurricane to affect Baja since Hurricane Liza of 1976 brushed the peninsula as a Category 4 storm. Only seven Category 4 Eastern Pacific hurricane have hit Mexico in recorded history. Wind shear is light and forecast to remain low, and sea surface temperatures (Figure 2) are a very warm 30 C under the hurricane--about 1-2 degrees C above normal for this time of year. John's strength is likely to be controlled by difficult to predict eyewall replacement cycles over the next three days, and could be a Category 4 hurricane when it encounters Baja. An Air Force Hurricane Hunter aircraft is scheduled to investigate John at 11am PDT today.
Figure 2. Current sea surface temperatures along the Pacific coast. Temperatures in the Gulf of California may not be accurate, due to difficulties retrieving the temperature via satellite measurements in such a narrow body of water. The red line separating blue colors from yellow marks the 26 C isotherm--the critical temperature needed to sustain a tropical cyclone. Note the very cool waters extending from the California border southwards along the coast. This long stretch of cool water will make it difficult for John to hold together if it tries to approach California. Image credit: NOAA/AOML.
Is John a threat to the U.S.?
In yesterday's blog, I discussed in detail the historical record of the five Eastern Pacific tropical cyclones that have affected the U.S. with tropical storm force winds. The latest model guidance still suggests the possibility John could come far enough north to affect the U.S., but it is looking increasingly unlikely. A ridge of high pressure is expected to build in and force John to the west about the time the storm reaches Baja. The GFDL model, however, takes the storm about halfway up the Gulf of California before turning it westward across Baja and away from North America.
Super Typhoon Ioke
The incredible Category 4 Super Typhoon Ioke made almost a direct hit on tiny Wake Island in the Pacific, passing just to the northeast of the island. The island experienced the eyewall of the left front quadrant of the super typhoon, but probably missed the calm of the eye. Observations from Wake showed winds of 78 mph gusting to 100 mph and a pressure of 934 mb before the instrument failed at 2:18am EDT this morning. Ioke continues to be a borderline Category 4/5 super typhoon, and is not expected to decline to category 3 strength for several more days. This would probably make it the longest-lived Category 4 or higher storm on record anywhere.
African tropical waves
The large spiral of low clouds near 18N 50W surrounded by a large cloud of dry air and African dust continues to spin, and now has some thunderstorm activity near the center. This thunderstorm activity developed last night and stayed on through the morning, an indication that the dry air surrounding this system is starting to dilute. As the environment continues to moisten, this system will have the potential for development. Development would likely not happen until Sunday at the earliest, when it should be near the northern Lesser Antilles Islands.
A tropical wave near 12N 37W, a few hundred miles southwest of the Cape Verde Islands, has changed little in organization the past day. Some slow development of this system is possible over the next few days, but doesn't appear likely.
A spinning area of clouds few hundred miles north of Puerto Rico is associated with an upper level low pressure system. Development is not expected of this system.
I'll be back this afternoon with an update. Tonight, I'll be talking live at 8:45pm EDT on the Barometer Bob show, live from northeast Florida:
Jeff Masters
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Dr. Masters co-founded wunderground in 1995. He flew with the NOAA Hurricane Hunters from 1986-1990. Co-blogging with him: Bob Henson, @bhensonweather
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Eric Petersen
"Pet Voices" are a real thing...
by Eric Petersen
posted Jul 12 2013 10:17AM
Why do people use such funny and/or weird voices when talking to their pets?
I do it, I admit it. In fact, Selena asked me to talk to her like I was talking to my cat, Bulter, so I said (in a mushy baby talk type inflection): "How's my boy... My best friend, My little Butler Boy". "Oh My God" she yells, bursting into laughter!
She looked at me as if I had just made the strangest, most bizarre statement ever. "Oh please, like you don't talk to Fozzie the same way?!" I said in my defense. Shortly thereafter she too had to admit that she had a "Pet Voice" that she would employ when talking to her cat too.
I sincerely believe there is a "cat voice" that we cat owners talk in; it's a different language that only we and other cat owners (and maybe the people that work at PetsMart) can understand.
So with that said I ask you pet owners:
Do you use a "Pet Voice" when you speak to your pet? (secretly I already know the answer).
Join us Monday morning at 8:15 and use it, and you may be rewarded with tickets to our
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Talk to you then!!!
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From chef Tyler Florence's favorite blueberry-banana pancakes to a light and fluffy baked apple pancake, here are superb pancake recipes.
Flax-Coconut Pancakes
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Elisabeth Prueitt always mixes ground flax into her pancake batter. "I've never felt great about the low nutritional value of pancakes—it's like eating cake for breakfast—but the flax adds fiber, omega-3s and minerals," she says.


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Category:Scores featuring the melodica
Free public domain sheet music from IMSLP / Petrucci Music Library
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GAO's 2013 High-Risk Series:
An Update
GAO-13-359T: Published: Feb 14, 2013. Publicly Released: Feb 14, 2013.
Additional Materials:
- Highlights Page:
- Full Report:
- Accessible Text:
(202) 512-6806
Office of Public Affairs
(202) 512-4800
What GAO Found
In February 2011, GAO detailed 30 high-risk areas. Sufficient progress has been made to remove the high-risk designation from two areas.
- Management of Interagency Contracting. Improvements include (1) continued progress made by agencies in addressing identified deficiencies, (2) establishment of additional management controls, (3) creation of a policy framework for establishing new interagency contracts, and (4) steps taken to address the need for better data on these contracts.
- Internal Revenue Service Business Systems Modernization. We are removing this area because progress has been made in addressing significant weaknesses in information technology and financial management capabilities. IRS delivered the initial phase of its cornerstone tax processing project and began the daily processing and posting of individual taxpayer accounts in January 2012. This enhanced tax administration and improved service by enabling faster refunds for more taxpayers, allowing more timely account updates, and faster issuance of taxpayer notices. IRS has put in place close to 80 percent of the practices needed for an effective investment management process, including all of the processes needed for effective project oversight.
While these two areas have been removed from the High Risk List, GAO will continue to monitor them.
This year, GAO has added two areas.
- Limiting the Federal Government's Fiscal Exposure by Better Managing Climate Change Risks. Climate change creates significant financial risks for the federal government, which owns extensive infrastructure, such as defense installations; insures property through the National Flood Insurance Program; and provides emergency aid in response to natural disasters. The federal government is not well positioned to address the fiscal exposure presented by climate change, and needs a government wide strategic approach with strong leadership to manage related risks.
- Mitigating Gaps in Weather Satellite Data. Potential gaps in environmental satellite data beginning as early as 2014 and lasting as long as 53 months have led to concerns that future weather forecasts and warnings--including warnings of extreme events such as hurricanes, storm surges, and floods--will be less accurate and timely. A number of decisions are needed to ensure contingency and continuity plans can be implemented effectively.
In the past 2 years notable progress has been made in the vast majority of areas that remain on GAO's High Risk List. This progress is due to the combined efforts of the Congress through oversight and legislation, the Office of Management and Budget through its leadership and coordination, and the agencies through their efforts to take corrective actions to address longstanding problems and implement related GAO recommendations.
Why GAO Did This Study
The federal government is the world's largest and most complex entity, with about $3.5 trillion in outlays in fiscal year 2012 funding a broad array of programs and operations. GAO maintains a program to focus attention on government operations that it identifies as high risk due to their greater vulnerabilities to fraud, waste, abuse, and mismanagement or the need for transformation to address economy, efficiency, or effectiveness challenges. Since 1990, more than one-third of the areas previously designated as high risk have been removed from the list because sufficient progress was made to address the problems identified.
This biennial update describes the status of high-risk areas listed in 2011 and identifies any new high-risk area needing attention by Congress and the executive branch. Solutions to high-risk problems offer the potential to save billions of dollars, improve service to the public, and strengthen the performance and accountability of the U.S. government.
What GAO Recommends
This report contains GAOs views on progress made and what remains to be done to bring about lasting solutions for each high-risk area. Perseverance by the executive branch in implementing GAOs recommended solutions and continued oversight and action by Congress are essential to achieving progress. GAO is dedicated to continue working with Congress and the executive branch to help ensure additional progress is made.
For more information, contact J. Christopher Mihm at (202) 512-6806 or firstname.lastname@example.com.
Nov 19, 2015
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Oct 28, 2015
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Oct 20, 2015
2020 Census:Additional Actions Would Help the Bureau Realize Potential Administrative Records Cost SavingsGAO-16-48: Published: Oct 20, 2015. Publicly Released: Oct 20, 2015.
Oct 14, 2015
Sole Source Contracting:Defining and Tracking Bridge Contracts Would Help Agencies Manage Their UseGAO-16-15: Published: Oct 14, 2015. Publicly Released: Oct 14, 2015.
Federal Real Property:Performance Goals and Targets Needed to Help Stem GSA's Reliance on Lease Extensions and HoldoversGAO-15-741: Published: Sep 30, 2015. Publicly Released: Oct 14, 2015.
Oct 5, 2015
U.S. Postal Service:Actions Needed to Make Delivery Performance Information More Complete, Useful, and TransparentGAO-15-756: Published: Sep 30, 2015. Publicly Released: Oct 5, 2015.
Sep 30, 2015
Managing for Results:Implementation of GPRA Modernization Act Has Yielded Mixed Progress in Addressing Pressing Governance ChallengesGAO-15-819: Published: Sep 30, 2015. Publicly Released: Sep 30, 2015.
Sep 23, 2015
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Sep 16, 2015
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An Opinionated Childless Woman
A writer, educator, small-business owner and opinionated childless woman comments on life
Monday, January 19, 2015
Michelle Spencer's invitation is awaiting your response
Tuesday, January 13, 2015
I'd like to add you to my professional network on LinkedIn
Wednesday, December 7, 2011
Put Your Best People on your Most Boring Challenges
A guest article today from The Harvard Review via the Dynamic Small Business Network.
Don't you love it when someone crystalizes what you know already but haven't been able to put into words?
as organizations scale, they often slip, slide and default into less than mediocre processes that get the job done. Unfortunately, the job gets done in manual, jury-rigged or improvised ways that are deadly dull to manage and excruciatingly boring to fix…. [T]he real barriers to growth aren't around the ingenuity of value-added implementations; they're in the lag-behind, necessary evil support systems and three-quarter baked infrastructures desperately attempting to support them.
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Tag:Elvis Andrus
Posted on: October 21, 2011 1:49 am
En route to a classic?
ST. LOUIS -- Two World Series games. Two well-played, one-run games.
You never know, but this could be the start of something great.
"It was fun," Rangers first baseman Michael Young said following Texas' 2-1 Game 2 win Thursday. "Dave McKay [Cardinals first-base coach] came up to me in the eighth or ninth inning and said something like, 'Competition at its finest.' And I said, 'Yeah, this is fun, isn't it?'
"That's exactly what it is. Fun."
The game was scoreless through six innings. The only other time in World Series history the first two games have even been scoreless through three came in 1961 when the Yankees and Reds did it.
Of course, by the end of the ninth, it was the Rangers who were having the most fun. Staring at an 0-2 hole heading back to Texas, the fact that they were able to squeeze two ninth-inning runs out of the rigid St. Louis bullpen to even the series could be a series-changer.
"It's huge," shortstop Elvis Andrus said. "We came here for sure wanting to get a win so we could get back home with a chance to win. It was a pretty good game. Jaime Garcia did a really good job.
"Our approach was let him pitch, because he gets wild. He didn't get wild."
But the ninth inning did, and this series could.
Fasten your seatbelts.
Category: MLB
Posted on: August 9, 2009 8:44 pm
Rangers pitch, catch and are having a ball
You don't have to look far to see why Texas is making a serious run at playing meaningful September games this season.
Not only are the Rangers pitching better (seventh in the American League with a 4.21 ERA after ranking last in the majors at 5.37 in 2008), their defense also is significantly improved (the Rangers' .984 fielding percentage is tied for sixth in the AL after ranking as the worst in the AL in both 2007 and 2008).
Most importantly, the Rangers' biggest gamble, installing rookie Elvis Andrus at shortstop and moving Michael Young over to third base, has been an unmitigated success.
Andrus has started 91 games, most of any rookie in the majors, and has a .970 fielding percentage. He's committed just two errors over his past 30 games and leads all major-league shortstops in chances-per-nine-innings (5.27) and putouts (181).
The youngest position player on an opening-day roster (20 years, 223 days old) and second-youngest overall (Detroit pitcher Rick Porcello was a few days younger), Andrus also is 20-for-22 in steal attempts and has become only the 10th player in history to have a 20-steal season at the age of 20.
"The talent was obvious," Rangers general manager Jon Daniels says. "Our guys throughout the system really did a nice job. His makeup, knowing who Elvis was and whether he would be able to handle it."
Who knows what the future holds, but it's difficult to imagine a rookie's transition going more seamlessly than that of Andrus (once Young accepted the transition, of course, after his initial trade request last winter).
Toward the end of spring training, a Rangers' staff member put his arm around Daniels and said, "Well, we did it."
"Did what?" Daniels asked.
"We got through spring training with never a question about should we send him back down, should we move Michael Young back to shortstop," the staffer said.
Perhaps more importantly, five months into the 2009 season, there still are no questions.
Likes: We've reached that time of the season where the games are beginning to pick up meaning, and Texas' run will become very interesting over the next few weeks. After three with the Indians this week to complete their current trip to Oakland, Anaheim and Cleveland, the Rangers go home to host Boston -- whome they're battling for the AL Wild-Card lead -- and Minnesota, then they face a killer trip to Tampa Bay, the Yankees and Minnesota. If they're still standing after that, the Rangers will face their most interesting September in years. ... Reading coverage of the 40th anniversaries of Woodstock and of the Beatles shooting their famous Abbey Road album cover photo. ... Warm summer nights. ... Watching the Yankees-Red Sox 15-inning game the other night. Riveting. But 3 hours and 17 minutes to play a scoreless nine innings? ... This new Awful Umpiring web site sure looks like a winner.
Dislikes: Far too many back to school ads. I mean, I'm thrilled that doesn't include me, but come on. Here in the digital age, with all of the technological advances, can't we figure out a way to make summer last 12 months?
Rock 'N' Roll Lyric of the Day:
" It's not very far from Sulphur to Sugarcane
-- Elvis Costello, Sulpher to Sugarcane
Category: MLB
Tags: Elvis Andrus, Elvis Costello, Texas Rangers


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To reiterate my view on Passport Potash for 2013-- I am hopeful that this year junior natural resource stocks will get a fresh look. Coal, iron ore, potash, gold, everything got killed in 2012. Passport is trading at just 2% of what I believe the company's Preliminary Economic Assessment, (PEA) will show the project's NPV to be. This belief is based on the $3.8 billion NPV in Prospect Global's PEA. Remember, Passport has 122k acres and Prospect Global 94k acres. Passport's resource is several hundred feet shallower than Prospect Global's. Since Apollo is willing to loan Prospect Global $100 million, they must believe that Prospect Global is worth at that much. In fact, I'm highly confident that Apollo must think Prospect Global is worth $150 million or more. Why? Because Apollo is one of the most powerful and smartest investor group in the world. They would insist on being over-collateralized, and they would surely get what they asked for. I've argued that Passport is worth the same or more than Prospect Global. If true, then Passport's fully-diluted shares at a $150 million valuation are worth about 55 cents. I think we have a good shot at 55 cents per share after the PEA comes out in 1q 2013, and a good shot at 80 cents per share if/when Passport gets a strategic investor and/or an off-take agreement AT THE PROJECT LEVEL, meaning no further equity dilution. Investors have been burned in natural resource stocks. Understandably, investors including hedge funds mutual funds and natural resource funds are scared to take a stand. I think that once Passport's PEA is released the shares will be too cheap to ignore. Unless someone can show me how/why Passport is worth just 25% of what Prospect Global is worth, I think Passport could be a stunning investment in 2013. Since my rough estimates on valuation are tied to Prospect Global, keep an eye on that stock as well, ticker PGRX. I think PGRX could hit $2 per share within a few months. At that price, the valuation on PGRX would imply a stock price for Passport of 65-70 cents and a price of $1.00 per share would be a possibilty for 2013. All of this predicated on junior natural resource stocks having a strong year and no further equity raises for Passport.


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Will We Have Another September Crisis
Are we headed for another September Crisis?
In general the period from May until November is a time for market underperformance. The average performance for the period from May 1 through October 31 each year since 1950 is just 1.2%. The average performance for the other six months of the year (November 1 through April 30) each year since 1950 is 7.0%.
Historically, September is has been the single worst month for stocks over the last 80 years. Since 1929, on average the S&P 500 has fallen 1.1% in September.
This is only one of three months to have an average negative return over this period. And it is the single worst month of the year (the other two are May with an average return of -0.1% and February with an average return of -0.2%).
Moreover, it is the Autumn when banking and financial crises have a tendency to occur. In terms of specific months, September and October are the worst with issues that lead up crashes erupting in September with October being when the actual crashes finally hit. There were Crashes during these months in 1907, 1929, 1987, and 2008.
All told, there have been a total of 147 crises since 1970 in the world. September accounted for 27 of them, the single largest month.
For certain stocks are definitively in a bubble. Based simply on CAPE (cyclical adjusted price to earnings) the market is significantly overvalued with a reading of nearly 24 (anything over 15 is overvalued).
Indeed, we've only been at this level of valuation during major stock tops (1929, 1966, 2000, and 2007)
Now we have the Government potentially shutting down. The markets are open on Monday which will be the last day in September.
Are we going to get another September Crisis?
For a free Special Report on how to prep your portfolio for a market collapse, visit us at: http://gainspainscapital.com/protect-your-portfolio/
Best Regards
Graham Summers
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Obama wants a shutdown ... We'll get one ... TPTB will allow the market to fall making the FED look good and at the same time placing blame for the fall and the 'bad' economy on the Repubs
Our controllers seem to have an evil fetish regarding anniversary dates. We keep getting false flag attacks on 9/11, and warnings on other anniversaries.
I find it striking that 'Black Tuesday' was October 29, 1929. This October 29 happens to fall on a Tuesday, also.
And to add:
Strange that 911 is the US emergency call number ... it's as if our controllers are blatantly taunting us with clues and arrogantly saying, "What are you plebs/goyim/sheep/morons going to do about it?"
Daddy Bush was overheard saying something like, "If they knew what we have really done, then they (the 99%) would hang us."
You have a good point OldPhart and I, at 70 years of age, have noticed the same as you.
The psychopaths who run the Empire apparently delight in dropping clues as to their agenda of total world control ... ever bolder with the PNAC/NWO because it's now proven that there will never be any mass resistance.
So how does the September Kenya shootout effect Obama's domestic antigun efforts?
October has always been my pick for crisis month, at least since my January, May and July picks rolled by.
"October has always been my pick for crisis month,..."
What if something happens tomorrow and leads into October?
We see the perfect setup for a false flag event beforeus now. Hopefully, it will not be something nuklear, but it could happen September 30th on a Monday morning to milk and pump FEAR in the news-feeds all week as is the norm. It could then lead on into October 1st, and then the head-puppet could declare martial law using that to cover up the failure of the govt to pass a budget because there is NO money to pay the budget. This and the whole obamacare scam is at stake. What a brew of chaotic babylonia stew is it.
Either way, something wicked comes and everybody knows it. This kind of insanity in things like the Hegelian dialectic, and warmongering for profits using false flag events to start wars has gone way to far of the deck. It is a floating turd that people keep apple bobbing for to eat. Why? Ignorance. Pure ignorance of what is right, and what is wrong. Many are to busy in the left right, republicrat and demopublican, up is down, and black is white paradigm, instead of the basic right and wrong differences.
So, in this important time it is all hands on deck as we head into these uncertain waters. All we want for Christmas is Peace on Earth. Can we do that, or will the warmongering, profiteering, murdering, evil population reductionists have their way? The truth is, 99.9% of the world's people have had enough of these crazed babylonians. It is way past time to clean house!
Just for fun, here is an old report. Was it a year early? Time will tell. Hopefully, as always, the Light on the possibilities is brighter than the energy in the evil ones to create another false flag event, and the horrid caca-roaches will not crawl out from the darkness to do their evil deeds.
Ordinarily I would ask if a bear shits in the woods, but we only have one and a half days left ... are we aloud to pre-date our October catastrophe so we can call it a September catastrophe???
aloud? Try allowed next time. Jesus!
So who are you-- the negative vote? Another idiot that never read a third grade grammer book?
Don't know about anyone else, but if Washington goes home forever and the market tanks 75%,
my sun will still rise in the east and the dogs will still get fed.
Of all the Phoenix Capital articles this is certainly one of them.
naw, there won't be no stinkiin' crash! If there was, it'd be the most over-predicted one in the history of mankind.
Things will keep chuggin' along....downhill....
If you predict anything long enough it is bound to happen. It is the same with a car. You don't worry about when a flat tyre happens if you have a spare in the boot.
Tyre? Boot? How about speaking English so' sew can understand you?
You do realize September is about over, right?
WTF is Sersly? Hope it is not contagious.
With ONE day left in Sept. ... I can't think of anyone I wouldnt follow more than Graham
What a douche....I think he meant Oct but with Ben printing he'd be wrong on that too


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EASTVILLE — Northampton County Sheriff David Doughty announced the following arrests for September:
» Christopher John Ashton, 33, of Painter, was arrested Sept. 4 on charges of felony kidnapping, misdemeanor vandalism and misdemeanor assault and battery. He was released on bond.
» Walter Merrill Lewis III, 42, of Nassawadox, was arrested on Sept. 18 on charges of felony grand larceny. He has been released on bond.
» Michael Edward Wesch, 31, of Willis Wharf, was arrested Sept. 23 on charges of felony grand larceny and felony receiving stolen property.
He has been released on bond.


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Hempstead High School announces comeback
After Hempstead High School was placed on the lowest academic rung, the Hempstead School Board rehired Reginald Stroughn to the position of Hempstead High School principal, after having held that position from 2003-09. Stroughn Friday announced some of his plans to raise the school's academic status and increase the graduation rate. Videojournalist: Jeffrey Basinger (Aug. 23, 2013)
Newsday.com now uses Facebook for our comment boards. Please read our guidelines and connect your Facebook account to comment.
Blue Angels begin prepping for 2016 Bethpage Air Show Gillibrand: 'FEMA has failed to do its job' Brentwood man killed, second man wounded in shooting Two injured in early morning fire at North Babylon house North Babylon mother killed crossing Southern State Parkway after surviving accident Black Friday protest Blimp makes unplanned landing Stony Brook miracle baby 3 luxury East End homes on the market Incoming commissioner looking to bring fresh perspective to Suffolk police Help found during tough times Records: Councilman traded pills for steroids, cash


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Furnace Troubleshooting & Repair Contractor – Minneapolis St. Paul, MN
$20 Off Furnace Repair Service
- Save $20 on furnace repair service. We solve over 95% of all furnace problems within 24-48 hours.
- Applicable to regular service and emergency service.
Winters in the Minneapolis St Paul area can be brutal. It's hard for most of us to understand how our ancestors managed to survive during the winter, living in drafty houses heated only with firewood. Today, of course, we have modern forced air heating systems and well-insulated homes. We live in comfortable surroundings, despite the harsh weather. Modern furnace systems are so reliable that we rarely think about what would happen if they just stopped working.
But, since furnaces are mechanical devices, they can break down. In addition, most of them rely on electrical power to operate fans and other components and will not run at all if the electricity fails. Every Minnesotan should have a plan for what to do if the heat fails. Fortunately, such a plan is relatively easy to put together. Here's what to do if your heat fails:
- Don't Panic – If the forced-air heating furnace stops working, it's not an immediate emergency. Most homes only lose one or two degrees of temperature per hour, even when the temperature outside is at zero degrees or below. You have plenty of time to take care of things.
- Don't Endanger Your Family – Do not be tempted to use improvised heating measures. Portable kerosene and propane heaters are not safe for use inside a home, due to the risk of carbon monoxide poisoning. For the same reason, operating a gas kitchen range is an unsafe way to heat your home.
- Determine the Cause of Failure – Troubleshooting the situation is your first step. Did the electrical power fail? If so, that's the reason you have no heat. Your furnace can't run without electricity. Was it the thermostat? Try resetting the temperature on the thermostat. Turn it down, and then turn it back up. If the power is on, but you still have no heat, check the circuit breaker or fuse for the furnace. Resetting the breaker or replacing the fuse may be all you have to do. Remember that the furnace can't operate without electricity. If none of those fix the problem, the problem is probably elsewhere, and you may need outside help.
- Electric Power Outage – If the power has failed in your home, call your electric power company's toll-free number. Report the power outage. Usually, your entire neighborhood will have no power. The power company should be able to give you a rough estimate of when the power will be back on. Typically, it's not more than a few hours, so throw on a sweater and wait it out. If the problem is limited to your home, they'll check it for you, but you may have to call an electrician if the problem is in your house's wiring.
- Furnace Breakdown – If the electricity is on, none of the tips above has worked, and you're in the Minneapolis St. Paul area, call our Minnesota heating company as soon as you can. We have experienced repair crews ready to help, even after hours and on weekends. We service and repair all brands of forced-air heating systems. We'll advise you about how soon a repair technician will arrive. Once the service technician is at your home, he'll advise you after diagnosing the problem. Most problems can be repaired quickly and your home will be warm again. We make emergency furnace repair calls.
- Worst Case Scenarios – Although it's unlikely, a major failure may mean that your furnace needs to be replaced or the power may be out for more than 24 hours. If that occurs, you may have to move yourself and your family to warmer surroundings. If you have to vacate your home while repairs are made, call a plumber before you leave and have him shut off the water and drain your internal plumbing to prevent burst pipes if the temperature drops too low.
- Away from Home – Before traveling in the winter months, you should arrange for someone to check your home once a day. A power or furnace failure while you're out of town can be a disaster. Having someone make a daily house check allows necessary repairs to be done before any damage occurs. Make sure that person knows how to contact you when you're away.
Minneapolis St. Paul Most Reliable Heating Repair Service Contractor
Over 90% of the time, a loss of heat in your home will be resolved before there's any risk of damage to your home in the Minnesota winter. The power will come back on, or the furnace will be repaired quickly. Living in the Minneapolis and St. Paul area, you can minimize the risks of furnace failure by having our Minnesota heating company inspect, clean, and tune-up your system once a year. It's a wise investment that will save you money and help prevent problems due to lack of maintenance. If your furnace hasn't been inspected for some time, call Residential Heating and Air Conditioning today and get the peace of mind that comes with knowing your forced-air heating system is in top condition.
As a leading heating contractor in Minnesota, we offer affordable furnace repair service. Our pricing is competitive and our quality is unmatched. If you furnace breaks down or doesn't work properly, we are ready to help. Our affordable repair service starts with a diagnosis that will pinpoint the root cause of the problem. Then, we present you with a price quote on how much the furnace repair costs. Once you approve the cost, we will get the job finished in a timely fashion. Our service vans are stocked with replacement parts. In case we need special parts, we have quick access to large parts supplies. Our goal is get your heat back on as quickly as possible at an affordable price. Having a heating contractor that you can trust in the middle of a Minnesota winter gives you peace of mind.


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Jennifer Aniston Debuts New Haircut, Says Her Stylist 'Chopped All My Hair Off'
Jennifer Aniston is making hair-story once more. The actress, 44, had more than six inches lopped off of her famous head of dirty-blond hair last Thursday; she quietly debuted the sexy-messy, bob-like 'do while running errands in Los Angeles on Monday, Nov. 4, wearing a black top, brown blazer, jeans and shades, and a neutral expression.
Chatting with Vogue.com before the new photos emerged, Aniston explained that her longtime hairstylist Chris McMillan (who created the now-iconic, hated-by-Aniston "Rachel" cut back in the '90s) did the honors: "Chris McMillan actually chopped all my hair off!" The "We're the Millers" star clarified to the style bible's site that there was no master plan behind the latest cut.
"I actually don't have any red carpets coming up," said Justin Theroux's fiancee. "This is truly just for me!"
PHOTOS: Her bikini body through the ages
"It's right at my jaw line, maybe a little longer," she mused. "It was kind of spur-of-the-moment," she continued, explaining that the 'do sported by Vogue stylist Lawren Howell, whom Aniston noticed on TV, was the inspiration. And the famously coiffed star is happy with the results. "I don't know, man. I did it! I feel great. I feel lighter. It's simple, it's really simple, that's for sure," she says.
PHOTOS: All of Jen's Us Weekly covers!
In an earlier interview with Elle, Aniston also mentioned the cut, and said that her longer tresses had reacted badly to a Brazilian blowout. "My hair went through a phase, this thing called a Brazilian and my hair did not react really well to it," she said of the chemically-intensive straightening treatment.
PHOTOS: Friends stars then and now
"I'm always one of those girls who does a big old chop just to get it really healthy, to repair all the [damage from] hair coloring and stuff like that," Aniston noted to Vogue. "And I just got bored, honestly. It's fun to change it up once in awhile." (See more photos at X17online.)
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Pilgrim House HostelJuly 24, 2013Hostel • Memphis, United States
Rented a room (double bed, private) for $50 today.
Rented a room (double bed, private) for $50 today.
Teamwork makes the dream work: make sure to be responsive to fellow passengers who can't figure out which line is which.
If you go Double Red, it's the fast track.
Not the right building. Check in to New Jersey State House.
The specials aren't any cheaper than ordering individual items.
Despite the name, many motorists think they're still in Delaware.
Visit http://www.gwsports.com/m from your mobile phone for upcoming Colonials soccer, lacrosse, and softball events!
From New York or Jersey? This is the closest you'll get to home.
Try the spanakopita. It's a game changer.
This summer, the Smith Center is finishing a $43 million renovation Check out M/W BBall, volleyball, swimming, w. polo and gymnastics this fall!
Try the Mac & Cheese with your Roast Beef dinner platter.
#GWU graduates have commencement here. Michelle Obama is the 2010 speaker.
Best on weeknights, especially if you like late nights, lowaikey bars and PBR.
Don't forget the fries. They're great here, with or without whiz
Get here between 2 and 4. Starting at four, the line gets LONG.
Try the hot horchata (rice milk/cinnamon syrup). It's delicious. Mexcican Hot Chocolate is great too.
If you're there to see Fela, make sure to be ready to dance! Don't hesitate, just have fun with it.
Don't forget the Cinnabon/Freshens on the other side of the building.


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The Rattlers made a statement Sunday before the loudest crowd of the season that could be heard all the way to Cleveland.
They struck fast, punished the San Jose SaberCats throughout and never let up in a 72-56 victory at US Airways Center that ended with shouts of "three-peat" from some of 8,581 fans.
The Rattlers (17-3) will try to hoist their third consecutive Foster Trophy on Aug. 23 when they meet the 19-1 Cleveland Gladiators in ArenaBowl XXVII at Quicken Loans Arena.
Cleveland is looking to celebrate a pro sports championship for the first time in 50 years after putting way the Orlando Predators earlier in the day.
Coach Kevin Guy made Arena Football League history, becoming the first coach to reach the championship game four consecutive seasons.
It came with late-season duress — three losses in the final four regular-season games — but it ended Sunday in the National Conference final with as fierce and punishing a performance as any the Rattlers exhibited in the Guy era.
"They played physical, they played relentless," Guy said. "That's the locker room I know."
Guy said he put in about 30 new plays for San Jose, which beat the Rattlers 62-33 on June 27, the teams' last meeting. He also moved guard Michael Huey to fullback with Alex Singleton banged up. Huey looked like one of the more dominant fullbacks in the league, not only protecting Nick Davila (20 of 34 for 276 yards and eight touchdowns), but showing athleticism, hurdling defenders on his way to a 14-yard scoring pass.
"Michael is so versatile for us," Guy said. "If you couldn't tell, we put in a lot of new plays this week. That threw them off track on defense. We were waiting on this. We were going to use players who were more talented to beat Portland. But we knew going against San Jose, we couldn't go in with the same game plan."
Davila erased the bad memory of the 8-for-22 performance in San Jose, finding Rod Windsor for a 17-yard touchdown after the Rattlers opened the game with a stop.
Photos: 2014 Arizona Rattlers
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Windsor later made a big diving catch to snare a low pass at the 1 that led to Davila's sneak touchdown. Windsor snared a 15-yard catch on a fourth-and-12 play from the Arizona 2 late in the final minute of the first half that led to Huey's touchdown and a 42-28 lead.
Windsor also broke a couple of tackles after catching a pass across the middle, changed directions and scored on a 16-yard play on the last play of the third quarter that gave the Rattlers a 58-35 lead.
"We wanted to show more energy, show we're the champs," Windsor said. "It's win or go home. You lay your body on the line."
Huey sensed a different team all week in practice.
"I think we got fooled by the wins; we got a kick in the pants when we got beat three times," Huey said. "We were all buttoned up. I could see it during the week. Everyone was dialed in at practice. It was quiet in the locker room. Just focused."
The SaberCats (14-6) unraveled at times, with the Rattlers sending starting quarterback Nathan Stanley to the sideline by the end of the first quarter for being ineffective and offensive lineman Duke Robinson getting ejected.
The Rattlers had five stops, forcing three turnovers, with Kerry Reed and Marquis Floyd coming up with interceptions and nose guard Anttaj Hawthorne recovering a Russ Michna fumbled snap.
"Our pass rush took over the game," Guy said. "We got after them."
What: ArenaBowl XXVII.
Who: Arizona Rattlers (17-3) at Cleveland Gladiators (19-1).
When: Aug. 23 at 5 p.m.
Where: at Quicken Loans Arena, Cleveland.


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Lightning McQueen
- Uploaded By rhopar33
- 2007-03-07 23:10:53
This was my first time cutting and pasting squares out of mmf. Worked better than I thought. Top tier is choc version of WASC and the bottom tier is WASC. Buttercream w/ mmf accents. Car provided by client.
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When you see an activity labelled with the 'Physical development' icon onCBeebies,it means that it can help your child to develop the skills needed for movement, awareness of the body, gaining a sense of space and understanding health and what the body needs.
This area of learning looks at how children develop their ability to move their bodies, hands, feet and fingers and use their senses and movements to explore the world around them. Children also learn to take care of their body, by being aware of what is healthy and developing good hygiene.
You might have heard people talk about 'fine' motor skills or 'gross' motor skills. These skills are simply actions that involve a person using their muscles.
Fine motor skills are small precise movements, needed for things like holding a pencil or using cutlery, and gross motor skills are larger movements, for example, crawling, walking and running. Like any other skill, babies and children need to practice movements regularly to get them right.


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clear concise practical medical advice
bachelor of medicine and bachelor of surgery, FCS ortho (sa),BSL.ACLS
quick medical advice for common and emergency conditions. qualified medical practitioner with a special interest in trauma and emergency medicine
4 years post graduate experience working with under privilidged communities in resource limited settings. runnning the A & E at a busy central hospital


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by Collinson FX
Pic of the Day 2012 470 World Championships Day 2
Collinson FX market Commentary: 15 May 2012
The markets continued to plunge fueled by the Greek political impasse and turmoil ensuing. Traditional Greek Political parties do not have the numbers to do a deal and the new emerging parties refuse to accept austerity. This will force a new election next month with support for the new anti-austerity parties likely to grow. This all certainly points to Greece leaving the EURO which could be the first shoe to drop.
It also could be the life saving operation needed to remove the cancer in an effort to save the patient! The EUR continued to weaken as the crises unfolds moving down to 1.2840. Spanish Bonds reflected this rising to highs.
EU Industrial Production contracted under the effects of austerity but the more worrying developments are political. Merkel is losing momentum in Germany with movement towards the anti-austerity left. The new pro growth, left message is a figment of the imagination. It is deficit and debt overwhelming these nations and until they can control this, disaster approaches. The fiscal austerity could be overcome through monetary intervention by the ECB.
Printing more money may solve the immediate crises but undermines the wealth of citizens. This may be the answer as it is working in the US although it will come to naught as inflation grips the Zone as in Germany many years ago. Wheelbarrows instead of wallets.
In the US a dearth of economic data focused the markets on Europe and pushed equities lower.
Commodities continued to suffer with the associated currencies. AUD fell below parity trading 0.9965 and the KIWI following 0.7775. Risk off trades drive market vulnerability endorsing the May Sell phenomena.
Collinson FX market Commentary: 14 May 2012
Markets steadied to close the week despite some disturbing new from JP Morgan.
The big news that shook markets was for once not the political upheaval gripping Europe. JPMorgan announced a huge loss attributed to some French trader working out of the City of London. This loss was described as a hedging bet gone wrong but to lose over US$2 Billion in under six weeks, it reeks of derivative trades. The loss was substantial but the implications were far more far-reaching. The systemic losses that lead to the GFC had been realized apparently. This was not to happen again so who has their pants down? Further revelations this week will answer more questions.
Meanwhile Europe continued to wobble with the Greek impasse continuing and no end in sight.
The EUR dropped to test 1.2900 and the GBP has also fallen to 1.6070.
The crises engulfing Europe has killed risk appetite and demand pushing the AUD back to parity and the KIWI to around 0.7800.
This week holds plenty of economic indicators but markets will be concentrating on political developments in Europe.
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Conrad Lachica
Graphic Designer | Illustrator
Pasig City, Philippines
Pasig City, Philippines
* To work as a Graphic Designer in a globally competitive company where I can be able to use my earned knowledge and training experiences. * To utilize my expertise in Arts, Graphics, Photography. * To maximize my advertising, creativity, and leadership skills in order to make a positive contribution in the company.
Powercycle, Inc. Graphic Artist August 2010 - September 2012 Manulife Business Processing Services Creative Services Associate 2 September 2012 - Present I'm available for Freelance works/activities *Prints/Layout/Graphic design *Flash Animations/Banners *Logo Design *Illustration (my specialty) *Painting (my specialty) *Digital Art/ Photo Manipulation (my specialty) *Webdesign Here are my contact details: cel.no: 0915-4513967 email address: email@example.com You can also visit me here. https://about.me/conradlachica