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Publications (35)101.74 Total impact
Article: Reductions in Stress Urinary Incontinence Episodes: What Is Clinically Important for Women?[Show abstract] [Hide abstract]
ABSTRACT: To expand our understanding of the clinical importance to patients with stress urinary incontinence (SUI) of reductions in incontinence episode frequency (IEF) that fall short of a complete cure. We used an integrated database that included data from 1,913 women with SUI who were enrolled in four randomized, placebo-controlled pharmaceutical clinical trials and examined the relationship between various levels of reduction in IEF and minimally clinical important difference (MCID) levels established for the validated Incontinence Quality of Life (I-QOL) questionnaire. The first decile of IEF reduction to exceed the within-group MCID was considered to be the point at which the reduction in IEF first became clinically important. The between-group MCID was then used to determine when further reductions in incontinence represented clinically relevant incremental improvements for patients. Improvements in condition-specific quality of life were not clinically important until the fifth decile of IEF reduction, representing a reduction in IEF >40% to <or=50%. Patients appreciated incremental clinically important benefits when IEF reductions exceeded 70%, with progressive improvements in condition-specific quality of life with higher levels of IEF reduction. The difference between a >70% to <or=80% reduction and a >90% to <or=100% reduction was clinically important. Reductions in IEF <or=40% do not appear to be clinically important for women with SUI. Patients appear to recognize important clinical value at reductions of approximately 50% and important incremental clinical value at reductions of approximately 75% and 90-100%. These thresholds may not apply to women seeking non-pharmaceutical treatments for SUI.Neurourology and Urodynamics 01/2009; 29(3):344-7. DOI:10.1002/nau.20744 · 2.87 Impact Factor
Article: Duloxetine compared with placebo for the treatment of women with mixed urinary incontinence[Show abstract] [Hide abstract]
ABSTRACT: Evaluate duloxetine in the treatment of women with mixed urinary incontinence (MUI). 588 women, 19-85 years old with >or=4 incontinence episodes/week were randomly assigned to duloxetine 80 mg/day (N = 300) or placebo (N = 288). Patients were classified into three symptom subgroups: stress or urge predominant MUI (SPMUI or UPMUI) or balanced MUI (BMUI) based on their responses to the validated Stress/Urge Incontinence Questionnaire. Half the population was randomly assigned to have urodynamics; SPMUI, UPMUI, and BMUI condition diagnoses were based on signs, symptoms, and urodynamic observations. The primary outcome measure was the change in incontinence episode frequency (IEF). Secondary outcome measures included the Incontinence Quality of Life (I-QOL) scores, the ICI Quality of Life (ICIQ-SF) score, and the Patient Global Impression of Improvement (PGI-I) rating. At baseline, women with SPMUI averaged 15.9 IEF/week (61% stress), those with UPMUI averaged 13.2 (70% urge), and those with BMUI averaged 16.5 (52% urge). Overall IEF decreases were significantly greater with duloxetine than placebo (median percent reduction 60% vs. 47%, P < 0.001); both UUI and SUI episodes were significantly decreased with duloxetine (median SUI IEF reduction 59% vs. 43%, P = 0.001; UUI IEF reduction 58% vs. 40%, P < 0.001). Duloxetine IEF decreases were significantly greater for patients with SPMUI conditions and symptoms and for those with UPMUI conditions but not symptoms. Significant benefits were also demonstrated with duloxetine for improvements in I-QOL total score (11.5 points vs. 8.1 points, P = 0.002), all three I-QOL subscale scores, and for the ICIQ-SF score (-2.6 vs. -1.7, P = 0.002) as well as for PGI-I ratings (much/very much better 44.2% vs. 27.3%, P = 0.001). Duloxetine demonstrated significant efficacy in this population of women with MUI.Neurourology and Urodynamics 03/2008; 27(3):212-21. DOI:10.1002/nau.20471 · 2.87 Impact Factor
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ABSTRACT: Compare the subjective and objective assessment of stress urinary incontinence (SUI) severity and improvement with treatment using patient- and clinician-rated global impression of severity (PGI-S, CGI-S) and improvement (PGI-I, CGI-I) scales. Five hundred fifty-three women with mild SUI were recruited via media advertising into a placebo-controlled duloxetine trial. PGI-S and CGI-S (normal, mild, moderate, severe) were administered at baseline and PGI-I and CGI-I (seven responses from "very much worse" to "very much better") during treatment. Incontinence episode frequency (IEF) was determined from diaries. Agreements between clinician and patient ratings were assessed using Kappa and degree of association with Spearman's correlation. There was only a slight agreement regarding severity, with 53% of ratings being different (Kappa = 0.14; 95%CI = 0.08, 0.20). When ratings differed, clinicians rated severity worse in 72% of cases than did patients. Agreement regarding improvement was moderate, with 42% of ratings being different (Kappa = 0.45; 95%CI = 0.39, 0.50). When ratings differed, clinicians rated improvement greater than did patients in 54% of cases. Patients' assessments of severity correlated better with IEF (0.33) than did the clinicians' (0.15). The correlations of PGI-I and CGI-I with IEF changes were similar (0.46 and 0.44). In this study, the subjective (patient) and objective (clinician) assessments of SUI improvement with treatment appear to be more closely aligned than are the assessments of initial SUI severity.International Urogynecology Journal 12/2007; 18(11):1291-5. DOI:10.1007/s00192-007-0326-8 · 1.96 Impact Factor
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ABSTRACT: To evaluate duloxetine (a serotonin-noradrenaline reuptake inhibitor) in women with symptoms of overactive bladder (OAB), as it has been shown to increase the bladder capacity in an animal model. In all, 306 women (aged 21-84 years) were recruited and randomly assigned to placebo (153) or duloxetine (80-mg/day for 4 weeks increased to 120-mg/day for 8 weeks; 153). Symptoms of OAB were defined as bothersome urinary urgency and/or urge urinary incontinence (UI) for > or =3 months. Participants were also required to have a mean daytime voiding interval (VI) of < or=2 h and urodynamic observations of either detrusor overactivity (DOA) or urgency which limited bladder capacity to <400 mL, both with no stress UI (SUI). The primary efficacy analysis compared the treatment effects on mean change from baseline to endpoint in the mean number of voiding episodes (VE)/24 h. The secondary efficacy analyses compared the treatment effects on the number of UI episodes (IE)/24 h, in the Incontinence Quality of Life questionnaire (I-QOL) score, and on the mean daytime VI. Safety was assessed with vital signs, adverse event reporting, routine laboratory testing, electrocardiogram, and the measurement of postvoid residual urine volumes (PVR). Patients randomized to duloxetine had significant improvements over those randomized to placebo for decreases in VE and IE, for increases in the daytime VI, and for improvements in I-QOL scores at both doses of duloxetine. Urodynamic studies showed no significant increases in maximum cystometric capacity or in the volume threshold for DOA. The most common treatment-emergent adverse events with duloxetine (nausea, 31%; dry mouth, 16%; dizziness, 14%; constipation, 14%; insomnia, 13%; and fatigue, 11%) were the same as those reported by women with SUI and were significantly more common with duloxetine than placebo. Laboratory assessments, vital signs and electrocardiograms were stable relative to baseline, with no relevant differences detected between groups. There was a significant difference in the change in PVR with duloxetine (<5 mL mean increase) but no patient reported hesitancy or retention. In this trial, duloxetine was better than placebo for treating women with 'wet' and 'dry' symptoms of OAB associated with DOA or a bladder capacity of <400 mL.BJU International 09/2007; 100(2):337-45. DOI:10.1111/j.1464-410X.2007.06980.x · 3.53 Impact Factor
Article: Effect of dose escalation on the tolerability and efficacy of duloxetine in the treatment of women with stress urinary incontinence[Show abstract] [Hide abstract]
ABSTRACT: To assess the impact of duloxetine dose escalation on tolerability and efficacy, 516 women with stress urinary incontinence were randomized to receive placebo or duloxetine in one of three regimens: 40 mg BID for 8 weeks, 40 mg QD for 2 weeks escalating to 40 mg BID for 6 weeks or 20 mg BID for 2 weeks escalating to 40 mg BID for 6 weeks. A non-inferiority analysis confirmed that the 20 mg BID starting dose was significantly better than the other two duloxetine regimens for nausea reduction (16.5% vs 25.2% and 29.4%). There were also significant differences in the discontinuation rates (7.5% vs 11.8% and 16.2%). The efficacy after 4 weeks was significantly better with duloxetine than with placebo. Starting duloxetine at 20 mg BID for 2 weeks before increasing to 40 mg BID significantly improved tolerability but did not impact duloxetine efficacy after all the subjects had been on 40 mg BID for at least 2 weeks.International Urogynecology Journal 09/2007; 18(8):919-29. DOI:10.1007/s00192-006-0256-x · 1.96 Impact Factor
Article: Duloxetine treatment of stress urinary incontinence in women: Effects of demographics, obesity, chronic lung disease, hypoestrogenism, diabetes mellitus, and depression on efficacy[Show abstract] [Hide abstract]
ABSTRACT: To identify poor responders, we evaluated the impact of demographic characteristics and comorbidities on efficacy using an integrated database including data from four large randomized controlled trials. Duloxetine has been shown to be effective in women with stress urinary incontinence (SUI). A total of 1913 women 22-83 years of age with predominant SUI (diagnosed using a validated clinical algorithm) were randomly assigned to receive placebo (n = 955) or duloxetine (n = 958) for 12 weeks. Efficacy outcome variables included a weekly incontinence episodes frequency (IEF) from patient-completed diaries, the Incontinence Quality-of-Life (I-QOL) questionnaire score, and a Patient Global Impression of Improvement rating. Subgroups selected a priori included: ethnicity, age, body mass index (BMI), chronic lung disease, hypoestrogenism, diabetes mellitus, and depression. For safety comparisons, adverse events were compared across age and ethnicity subgroups. Reduction in IEF was minimal and not significantly different between duloxetine and placebo in women with chronic lung disease. The decrease in IEF for women > or =65 years of age was slightly diminished for duloxetine and placebo groups, but the treatment differences were maintained. There was a significantly different I-QOL improvement by BMI subgroup, with greater increases in scores associated with a higher BMI (>28 kg/m2). There were no other notable subgroup impacts on efficacy. With the possible exception of chronic lung disease, no characteristic was identified that predicted a lack of treatment response with duloxetine in the treatment of women with SUI. Elderly patients may experience lower response rates to duloxetine presumably due to age related changes in the lower urinary tract.European Journal of Obstetrics & Gynecology and Reproductive Biology 07/2007; 133(1):105-13. DOI:10.1016/j.ejogrb.2006.05.003 · 1.70 Impact Factor
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ABSTRACT: The safety and tolerability of duloxetine for major depressive disorder (MDD), generalized anxiety disorder (GAD), diabetic peripheral neuropathic pain (DPNP), fibromyalgia, and lower urinary tract disorders (LUTD) (including female stress urinary incontinence [SUI] and other LUTDs) has been established in individual clinical studies. The objective of this manuscript is to characterize the overall safety profile of duloxetine, regardless of indication, based on data from the duloxetine exposures integrated safety database. The duloxetine exposures integrated safety database was examined using pooled data from 23,983 patients randomized to receive duloxetine in 64 studies for MDD, GAD, DPNP, fibromyalgia, or LUTDs. Evaluated aspects of drug safety included treatment-emergent adverse events (TEAEs), adverse events leading to discontinuation, serious adverse events (SAEs), clinical laboratory tests, vital signs, and electrocardiograms. Common TEAEs included nausea, headache, dry mouth, insomnia, constipation, dizziness, fatigue, somnolence, diarrhea, and hyperhidrosis. Most TEAEs emerged early; the majority were mild to moderate in severity, and did not worsen. Overall, discontinuation rates due to AEs were 20.0%. SAEs occurred at a rate of 3.5% and no single event was predominant. Mean pulse increased by < 2 beats per minute. Mean increases in systolic and diastolic blood pressure were < 1 mmHg. Mean alanine transaminase and aspartate transaminase values increased by < 2 U/L. The safety profile for the molecule from the overall duloxetine exposures integrated safety database suggests that benign and common pharmacologic side effects occur with duloxetine treatment. Because these pooled analyses do not allow for statistical comparison to placebo or active comparator, and include data from five different studied indications, these data do not suggest causality for AEs, nor are they necessarily generalizable to each disease stated studied.Current Medical Research and Opinion 01/2007; 23(1):175-84. DOI:10.1185/030079906X162719 · 2.65 Impact Factor
Article: Minimal Clinically Important Differences in Incontinence Quality-of-Life Scores in Stress Urinary Incontinenece[Show abstract] [Hide abstract]
ABSTRACT: To determine the clinically relevant reference points for the Incontinence Quality of Life (I-QOL) questionnaire scores in women with stress urinary incontinence and compare them with the treatment effects observed with duloxetine and placebo. Using data from 1133 women with predominant stress urinary incontinence in two randomized, placebo-controlled duloxetine studies, the within-treatment and between-treatment minimal clinically important differences (MCIDs) were obtained by anchoring the I-QOL scores to the validated Patient Global Impression of Improvement scale (PGI-I). The within-treatment MCID (mean I-QOL for women rating their condition "a little better" with treatment) and between-treatment MCID (difference in scores between the group ratings of "no change" and "a little better") were derived. The treatment effects were compared with these MCIDs. Real-time urinary diaries were completed, along with the I-QOL and PGI-I. The within-treatment and between-treatment MCID for the I-QOL total score was 6.3 and 2.5, respectively. The total and subscale scores had almost identical MCIDs. Duloxetine 80 mg significantly improved the I-QOL total and subscale scores. Treatment differences in the I-QOL scores exceeded the between-treatment MCID and the duloxetine I-QOL treatment effect exceeded the within-treatment MCID. The number of patients needed to treat to gain an additional I-QOL responder was 6.8. Improvements in I-QOL scores should be greater than the within-treatment MCID, and differences between two treatments should be greater than the between-treatment MCIDs, for statistically significant differences to be considered clinically meaningful. We propose 2.5 points as a reasonable guide for the I-QOL between-treatment MCID and 6.3 points for the within-treatment MCID.Urology 07/2006; 67(6):1304-8. DOI:10.1016/j.urology.2005.12.006 · 2.19 Impact Factor
Article: Duloxetine for the treatment of stress urinary incontinence in women: An integrated analysis of safety[Show abstract] [Hide abstract]
ABSTRACT: The objective was to characterize the safety of duloxetine for treatment of stress urinary incontinence (SUI) in women, using an integrated database generated from four published placebo-controlled clinical trials. The database included 1913 women randomized to duloxetine (N=958) or placebo (N=955), examining adverse events (AEs), serious adverse events (SAEs), vital signs, electrocardiograms, and laboratory analytes. AEs occurring initially or worsening during the double-blind treatment period were considered treatment-emergent (TEAE). Differences between duloxetine-treated and placebo-treated groups were compared statistically. Common TEAEs included: nausea (23.2%), dry mouth (13.4%), fatigue (12.7%), insomnia (12.6%), constipation (11.0%), headache (9.7%), dizziness (9.5%), somnolence (6.8%), and diarrhea (5.1%). Most TEAEs that emerged early were mild to moderate, rarely worsened, and resolved quickly. Overall AE discontinuation rates were 20.5% for duloxetine and 3.9% for placebo (P<.001). Most discontinuations (83%) occurred within the first month of treatment. SAEs were uncommon and did not differ between treatments. Statistically significant, but clinically unimportant mean increases in heart rate (2.4 bpm) and systolic and diastolic blood pressure (<or=2 mmHg) occurred. No arrhythmogenic potential was observed and any rare, transient, asymptomatic increases in hepatocellular enzymes normalized. Duloxetine was safe and tolerable, although transient AEs were not uncommon.European Journal of Obstetrics & Gynecology and Reproductive Biology 03/2006; 125(1):120-8. DOI:10.1016/j.ejogrb.2005.08.006 · 1.70 Impact Factor
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ABSTRACT: Duloxetine is the first relatively balanced serotonin and noradrenaline re-uptake inhibitor to be widely available for three indications including: major depressive disorder, peripheral diabetic neuropathic pain and female stress urinary incontinence, although it is not currently approved for all indications in all countries. Generally, duloxetine is safe and well-tolerated across indications, with few reported serious side effects. Common adverse events are consistent with the pharmacology of the molecule and are mainly referable to the gastrointestinal and the nervous systems. The studied dose range is up to 400 mg/day (administered 200 mg b.i.d) but the maximum dose approved for marketing is 120 mg/day (administered 60 mg b.i.d). Duloxetine is eliminated (half-life = 12.1 hours) primarily in the urine after extensive hepatic metabolism by multiple oxidative pathways, methylation and conjugation. Duloxetine would not be expected to cause clinically significant inhibition of the metabolic clearance of drugs metabolised by P450 (CYP)3A, (CYP)1A2, (CYP)2C9, or (CYP)2C19, but would be expected to cause some inhibition of CYP 2D6. Duloxetine should not be used in combination CYP 1A2 inhibitors or nonselective, irreversible monoamine oxidase inhibitors. The purpose of this review is to provide an overview of some of the most important information related to safety and tolerability of duloxetine.Expert Opinion on Drug Safety 12/2005; 4(6):987-93. DOI:10.1517/147403188.8.131.527 · 2.91 Impact Factor
Article: Validation of a Two-Item Quantitative Questionnaire for the Triage of Women With Urinary Incontinence[Show abstract] [Hide abstract]
ABSTRACT: To evaluate the reproducibility, construct validity, and preferences for the 2-item Stress/Urge Incontinence Questionnaire. The questionnaire asks a patient to recall the number of stress urinary incontinence and urge urinary incontinence episodes she experienced during the preceding week. The 4-week prospective study included 3 office visits and enrolled women with stress, urge, or mixed urinary incontinence symptoms. The test-retest reproducibility was assessed after 3 days, and the construct validity of the questionnaire was evaluated against a diary and other measures of incontinence severity and effect. The bother associated with completing (patients) or analyzing (physicians) the diary was assessed. Both groups also reported their time requirements and preferences for the questionnaire or diary. Reproducibility for the classification of symptoms was moderately strong (kappa = .536). Test-retest agreement was good (64-80%) for all but balanced mixed incontinence (38%). Intraclass correlations revealed good reproducibility for the number of stress (.694), urge (.703), and total (.726) incontinence episodes. Significant (P < .01) correlations with other measures of incontinence established construct validity. Patients and physicians reported it took less time to complete the questionnaire than the diary, but the majority said the completion or analysis of the diary was of little or no bother and preferred the diary. The Stress/Urge Incontinence Questionnaire is a valid tool that can be used in clinical practice to differentiate between symptoms of stress and urge urinary incontinence to make an initial diagnosis, especially in primary care where incontinence is not a focus of the practice.Obstetrics and Gynecology 10/2005; 106(4):767-73. DOI:10.1097/01.AOG.0000178168.33249.49 · 5.18 Impact Factor
Article: A randomised controlled trial of Duloxetine alone, pelvic floor muscle training alone, combined treatment and no active treatment in women with stress urinary incontinence[Show abstract] [Hide abstract]
ABSTRACT: We primarily compared the effectiveness of combined pelvic floor muscle training (PFMT) and duloxetine with imitation PFMT and placebo for 12 weeks in women with stress urinary incontinence (SUI). In addition, we compared the effectiveness of combined treatment with single treatments, single treatments with each other and single treatments with no treatment. This blinded, doubly controlled, randomized trial enrolled 201 women 18 to 75 years old with SUI at 17 incontinence centers in the Netherlands, United Kingdom and United States. Women averaged 2 or more incontinence episodes daily and were randomized to 1 of 4 combinations of 80 mg duloxetine daily, placebo, PFMT and imitation PFMT, including combined treatment (in 52), no active treatment (in 47), PFMT only (in 50) and duloxetine only (in 52). The primary efficacy measure was incontinence episode frequency. Other efficacy variables included the number of continence pads used and the Incontinence Quality of Life questionnaire score. The intent to treat population incontinence episode frequency analysis demonstrated the superiority of duloxetine with or without PFMT compared with no treatment or with PFMT alone. However, pad and Incontinence Quality of Life analyses suggested greater improvement with combined treatment than single treatment. A completer population analysis demonstrated the efficacy of duloxetine with or without PFMT and suggested combined treatment was more effective than either treatment alone. The data support significant efficacy of combined PFMT and duloxetine in the treatment of women with SUI. We hypothesize that complementary modes of action of duloxetine and PFMT may result in an additive effect of combined treatment.The Journal of Urology 06/2005; 173(5):1647-53. DOI:10.1097/01.ju.0000154167.90600.c6 · 4.47 Impact Factor
- European Urology Supplements 03/2005; 4(3):90-90. DOI:10.1016/S1569-9056(05)80357-4 · 3.37 Impact Factor
Article: 351How well do urodynamic observations and incontinence conditions correlate with incontinence symptoms?European Urology Supplements 03/2005; 4(3):90-90. DOI:10.1016/S1569-9056(05)80358-6 · 3.37 Impact Factor
Article: Poster 46: Validation of a Quantitative Questionnaire for Stress and Urge Urinary IncontinenceJournal of Pelvic Medicine and Surgery 01/2005; 11(Supplement 1). DOI:10.1097/01.spv.0000178924.99311.70
Article: The effect of previous experience and incontinence severity on the placebo response of stress urinary incontinence[Show abstract] [Hide abstract]
ABSTRACT: The placebo response associated with stress urinary incontinence (SUI) is sizeable but poorly understood. The aim of this study was to examine the relationship between previous treatment experience and baseline urinary incontinence severity with placebo response. Nine hundred twenty-one women ages 24 to 83 years received placebo in 4 12-week randomized trials evaluating duloxetine for SUI in 16 countries in Africa, Australia, Europe, and North and South America. Incontinence episode frequency (IEF) was calculated before and after randomization with entries from subject-completed real-time diaries. At baseline, subjects reported on their experience with previous continence surgery and with current pelvic floor muscle training (PFMT) with standardized questions. Analyses included Pearson correlations and the Wilcoxon two-sample test, and were based on intent-to-treat principles. The placebo group averaged 17 IEF per week at baseline. Fifty-five percent of placebo-treated subjects averaged >or=14 IEF/wk, 11.8% had previous continence surgery, and 16.5% currently performed PFMT. The overall median decrease in IEF with placebo was 33%, but ranged from 11% to 57% for individual countries. The placebo response was lower in women with more severe SUI (29.6% vs 36.4%, P=.07), in those who had previous continence surgery (25.0% vs 33.3%, P=.26), and for those using PFMT (23.6% vs 33.3%, P=.02). There was a significant positive correlation (rho=.44; P <.0001) between the placebo response within a country and that country's use rate for PFMT. Treatment naivete and less severe incontinence are associated with an increased placebo response in clinical trials for stress urinary incontinence, although this difference was statistically significant only for PFMT.American Journal of Obstetrics and Gynecology 08/2004; 191(1):194-7. DOI:10.1016/j.ajog.2004.03.089 · 4.70 Impact Factor
Article: Validation of a clinical algorithm to diagnose stress urinary incontinence for large studies[Show abstract] [Hide abstract]
ABSTRACT: We assessed the accuracy with which a clinical diagnostic algorithm for stress urinary incontinence (SUI) based on symptoms and signs without including urodynamics predicted the observation of urodynamic SUI and the condition of SUI. Such an algorithm would have applicability to ensure that the majority of women entering large SUI clinical trials would have urodynamic SUI and/or the condition of SUI without performing urodynamic testing in all subjects. A total of 1455 women with urinary incontinence at least 3 months in duration were enrolled in 3 randomized clinical trials (1 phase 2 and 2 phase 3 trials) of duloxetine vs placebo for the treatment of SUI in Europe and North America. Subjects were identified as having SUI based on a clinical algorithm that required a predominant symptom of SUI with a weekly incontinence episode frequency of 4 or greater (phase 2 study), or 7 or greater (phase 3 studies), absent predominant urge symptoms, normal diurnal and nocturnal frequency, a bladder capacity of 400 ml or greater, and a positive cough stress (sign of SUI) and stress pad test. Multichannel urodynamic studies were performed in a subset of 184 women at 23 study sites. Of these urodynamic tracings 173 (94%) were of adequate quality to make an assessment of the filling phase and assign a diagnosis of urodynamic SUI, detrusor overactivity or a normal filling phase. Two-sided 95% exact CIs for the proportions were calculated. The clinical algorithm had a positive predictive value of 90.2% for urodynamic SUI with or without detrusor overactivity and 76.9% for urodynamic SUI only (pure urodynamic SUI). The positive predictive value for the condition of pure SUI was 85.0%, while for the condition of SUI in pure and mixed forms the positive predictive value was 98.3%. Patient age, previous continence surgery or the severity of incontinence did not influence algorithm accuracy. The algorithm is suitably feasible and sufficiently predictive to be used in large clinical trials designed to evaluate conservative treatment for women with SUI. It ensures that the overwhelming majority of the study population would have urodynamic SUI and the condition of SUI.The Journal of Urology 07/2004; 171(6 Pt 1):2321-5. DOI:10.1097/01.ju.0000124909.31527.a9 · 4.47 Impact Factor
Article: Duloxetine versus placebo in the treatment of European and Canadian women with stress urinary incontinence. BJOG[Show abstract] [Hide abstract]
ABSTRACT: To assess the efficacy and safety of duloxetine in women with stress urinary incontinence. Randomised double-blind, placebo-controlled clinical trial. Fort-six centres in seven European countries and Canada. Four hundred and ninety-four women aged 24-83 years identified as having predominant symptoms of stress urinary incontinence using a clinical algorithm that was 100% predictive of urodynamic stress urinary incontinence in a subgroup of 34 women. The case definition included a predominant symptom of stress urinary incontinence with a weekly incontinence episode frequency > or =7, the absence of predominant symptoms of urge incontinence, normal diurnal and nocturnal frequencies, a bladder capacity > or =400 mL and both a positive cough stress test and positive stress pad test. Subjects completed two urinary diaries prior to randomisation and three diaries during the active treatment phase of the study, each completed during the week prior to monthly visits. Subjects also completed quality of life questionnaires at each visit. Safety was assessed by the evaluation of treatment-emergent adverse events, discontinuation of treatment because of adverse events, serious adverse events, vital sign measurements, electrocardiograms (ECG) and clinical laboratory tests. After a two-week placebo lead-in, women received placebo or duloxetine 40 mg BD for 12 weeks. The percentage decrease in incontinence episode frequency and the change in the Incontinence Quality of Life (I-QOL) questionnaire total score were prespecified as co-primary outcome variables in the protocol. Incontinence episode frequency decreased significantly with duloxetine compared with placebo (median decrease of 50%vs 29%; P= 0.002) with comparable improvements in the more severely incontinent subgroup (those experiencing at least 14 incontinence episodes per week at baseline; 56%vs 27% decreases; P < 0.001). The primary analysis of I-QOL scores did not reveal a significant difference between treatment groups, due primarily to the carrying forward of low scores from patients who discontinued treatment very early due to duloxetine-associated adverse events. The increase in I-QOL scores was significantly greater for duloxetine than for placebo at each of the three postrandomisation visits after 4, 8, and 12 weeks of treatment. Discontinuation rates for adverse events were higher for duloxetine (22%vs 5%; P < 0.001) with nausea being the most common reason for discontinuation (5.3%). Nausea tended to be mild to moderate, not progressive, and transient. The findings support duloxetine as a potential treatment for women with stress urinary incontinence.BJOG An International Journal of Obstetrics & Gynaecology 04/2004; 111(3):249-57. DOI:10.1111/j.1471-0528.2004.00067.x · 3.45 Impact Factor
Article: Duloxetine vs placebo in the treatment of stress urinary incontinence: a four-continent randomized clinical trial. BJU Int 93: 311-318[Show abstract] [Hide abstract]
ABSTRACT: To further assess, in a phase 3 study, treatment with duloxetine for women with stress urinary incontinence (SUI) in other geographical regions, including Argentina, Australia, Brazil, Finland, Poland, South Africa and Spain, as previous trials in North America and Europe provided evidence for the safety and efficacy of duloxetine as a pharmacological treatment for SUI in women. The study included 458 women aged 27-79 years enrolled in a double-blind, placebo-controlled trial. The patients with predominantly SUI were identified using a validated clinical algorithm. They were randomly assigned to receive placebo (231) or duloxetine 40 mg twice daily (227) for 12 weeks. The primary outcome variables included the incontinence episode frequency (IEF) and the Incontinence Quality of Life (I-QOL) questionnaire. Van Elteren's test was used to analyse the percentage changes in IEF where the stratification variable was weekly baseline IEF (IEF < 14 and > or = 14). Analysis of covariance was used to analyse I-QOL scores. The mean baseline IEF was 18.4/week; 55% of patients had a baseline IEF of > or = 14. There was a significantly greater median decrease in IEF with duloxetine with placebo (54% vs 40%, P = 0.05), with comparable significant improvements in quality of life (I-QOL score increases of 10.3 vs 6.4, P = 0.007). The improvements with duloxetine were associated with significantly greater increases in voiding intervals than with placebo (20.4 vs 8.5 min, P < 0.001). The placebo response was 10.7% and 12.5% higher than those reported in two European and North American phase 3 trials. This may have been related to more patients being naïve for incontinence management in the current trial. Discontinuation rates for adverse events were 1.7% for placebo and 17.2% for duloxetine (P < 0.001), with nausea being the most common reason for discontinuation (3.1%); it was the most common adverse event with duloxetine, but was mild or moderate in most (81%), did not worsen in any patient and resolved within 7 days in 60% and within 1 month in 86% of continuing patients; 88% of women who experienced nausea while taking duloxetine completed the trial. These results show improvements in incontinence and quality of life with duloxetine 40 mg twice daily for 12 weeks that are in keeping with those reported in two other recently completed phase 3 trials in Europe and North America.BJU International 03/2004; 93(3):311-8. DOI:10.1111/j.1464-410X.2004.04607.x · 3.53 Impact Factor
Article: 196 Comparing dry days in women with different stress urinary incontinence severity levels treated with duloxetine and placeboEuropean Urology Supplements 02/2004; 3(2):51-51. DOI:10.1016/S1569-9056(04)90197-2 · 3.37 Impact Factor
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Voice-over actor Peter Cullen is the man with the golden throat, contributing at least one important character to the lives of almost every American child of the last quarter-century.
When Michael Bay began work on his "Transformers" movie (see " 'Transformers': Checking Under The Hood For Juicy Plot Details" ), he was inundated with requests to have Cullen return as Optimus Prime, the tough-talking leader of the Autobots he voiced in the '80s TV show. And sure enough, when Bay announced Cullen's participation at Comic-Con, the crowd went berserk.
In an exclusive interview with MTV News, the man behind the truck gave us his thoughts on hitting the big screen, beating out George Clooney and forgetting "GoBots."
MTV: So how does it feel to be back as Optimus Prime?
Peter Cullen: Oh, it's wonderful. I'd like to take this opportunity to thank everybody for their affection for Optimus Prime and for their hard work and dedication.
MTV: Go back to your earliest "Transformers" memory. How did it all begin? Did the concept of talking, transforming cars seem silly to you?
Cullen: Oh, yeah. When I went to the audition, it was a cattle call — so many other actors coming and going that day. I had no idea what it was about; it was so revolutionary at the time. One of the characters, Optimus Prime, was a truck, and I began to understand a little bit of what was going on. When I read the character breakdown, Optimus stood out for being a good leader. I went into the audition with all the ingredients I felt necessary, and I applied them.
MTV: Did you really base the character on John Wayne?
Cullen: No, the John Wayne part of it really just came out in certain expressions. [What I was reading was] almost John Wayne lines, so I had to work to keep Optimus' own identity. John Wayne has a deep-end voice, and for a truck to have a high voice would be ridiculous. So I had to give him that basic imprint of the low-end voice. John Wayne was never intended to be the sound, but he did come out every now and then.
MTV: On the cartoon show, you also did the voice of Ironhide, correct?
Cullen: Oh, yeah. I did a bunch of them.
MTV: How do you decide: OK, this is the voice of a truck, and this is the voice of a sports car or a helicopter?
Cullen: Well, I have to keep them different. I always try to make a voice to go with the characteristics — if the guy's a hothead or he's cool, whatever. The guys who wrote these characters are brilliant, really just incredible brains, very creative people. So all the character traits were plugged in throughout the characters. Ironhide was easy, because he was a troublemaker who liked to disturb things and liked to get it on. I made him one of the good old boys. Like [doing Ironhide's voice], "Let's get it on!"
MTV: There were rumors for a long time that somebody like George Clooney would be brought in as Optimus. How did it feel to beat out all those pretty-boy A-listers?
Cullen: I'm happy, and I'm happy for the fanbase. Without the fanbase, I certainly would be on the normal highway route of being looked over. The genuine appreciation I have is to the fanbase.
MTV: In addition to "Transformers," you provided the voices for characters on "My Little Pony," "G.I. Joe," "GoBots," "Rainbow Brite," "Voltron" and so many others that meant a great deal to a generation. But a lot of people would say these were soulless commercials trying to sell us toys. What would you say to them?
Cullen: Well, I don't see it that way. It was a job, of course, doing Saturday-morning animation. But the way I saw it, I was performing for kids sitting on their carpet, staring at a TV while Dad washed the car and Mom was in the kitchen.
MTV: When I was a kid, I assumed that the people behind "Smurfs" hated "Snorks" people, that "Real Ghostbusters" people battled with "Ghostbusters" people, and that the "Transformers" and "GoBots" people were mortal enemies. You did voices on those last two shows. Was there competition?
Cullen: Nobody really put the dots together to consider rivalry on any level. If you were a voice-over actor, you would get the job and do the best you could. There was never any competition with other shows.
MTV: If "Transformers" is a big hit, I figure some studio will snatch up "GoBots" and turn that into a movie. Would you want to make a "GoBots" flick?
Cullen: [He laughs.] Somebody would have to tutor me on it, because to tell you the truth, I can't even remember "GoBots"! I'd have to look it up in Wikipedia or something. I can't even remember doing "GoBots" — I just remember the name. Do I sound stupid?
MTV: Oh, no! I'm sure you've done so many voices. Are there any other shows that people come up to you to talk about that you don't remember?
Cullen: Well, there are times, yeah. Generally speaking, somebody will come up to me and say, "You played such-and-such!" And I go, "I did? Well, what did he sound like?"
MTV: In recent years, you've been the voice of Eeyore in all these Disney projects. Do you ever find Eeyore accidentally turning into Optimus Prime while you're in the recording booth?
Cullen: Not really, because all the characters are so completely different. However, Eeyore is my low-end register, and Optimus Prime is down in that area too.
MTV: You were part of the great "Transformers" movie in 1986. Besides the animation, what's the biggest difference between that movie and Michael Bay's new flick?
Cullen: Well, I don't get whacked in this one. [He laughs.] I'm very happy to say that. It's a huge movie, wonderfully directed, extremely well-written. There is a wonderful excitement in the characters, the newness of it. How Optimus is relating on a more human level is also exciting.
MTV: Lately, various voice actors have been reading into machines that capture every possible sound, preserving them for future generations. Would you be willing to do something like that, so our kids' kids will still hear Optimus when he comes back again?
Cullen: I don't see anything wrong with that. I would love to — that would be an honor.
Check out everything we've got on "Transformers."
Visit Movies on MTV.com for more from Hollywood, including news, reviews, interviews and more.
For breaking news, celebrity columns, humor and more — updated around the clock — visit MTVMoviesBlog.com.
Want trailers? Visit the Trailer Park for the newest, scariest and funniest coming attractions anywhere.

subset: commoncrawl


text:
499 Views 2 Replies Latest reply: Dec 8, 2013 10:41 PM by Ducman916
Harvey Wallbanger Nov 18, 2013 1:58 AM
Re: canon P-150 scanner dont work in mountain lion in response to mandyapple
I just solved an issue I had installing the software drivers for the Canon p150 Scanner, where I was getting the error that it was unable to install the package since the developer was not identified. I'm using Mac OSS Mavericks on a Macbook Air 2013.
Simple fix -- went into System Preferences under Security and Privacy, General tab, then select the "allow apps to be downloaded from "Anywhere". I just tried to upload a screenshot but upload image was greyed out for some reason.
Software package then installed perfectly.
Ducman916 Dec 8, 2013 10:41 PM
Re: canon P-150 scanner dont work in mountain lion in response to Harvey Wallbanger
Brilliant, this fixed the problem. Thank you!


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On July 1, 2010, the General Court issued its long awaited judgment in AstraZeneca v Commission, almost five years after AstraZeneca launched its appeal against the EUR 60 million fine imposed on it by the Commission for abuse of dominance in 2005. The original Commission Decision was ground-breaking. It was the Commission's first abuse of dominance case in the pharmaceutical ("pharma") sector, a rare example of a case addressing the interaction between EU competition law and Intellectual Property ("IP") rights, and the types of abuse involved were novel. The decision launched the Commission on the path that eventually led to its 2009 pharmaceuticals sector inquiry; it also set the tone for a series of cases dealing with abuse of dominance in relation to the acquisition of IP rights, in particular patents, including Rambus and Qualcomm. The importance of the case is underlined by the persistent rumor that the Commission has delayed launching cases based on the results of the sector inquiry pending the outcome of the appeal. Many thought the Commission Decision would be overturned on appeal.
However, the General Court not only upheld the Commission's novel theories of abuse, it also appears to have extended their potential scope of application. And, in dismissing an appeal that challenged all aspects of the Commission Decision, the decision addresses a number of important issues, including the proper approach to market definition in the pharma sector, the scope for abuse in the context of applications for IP rights and litigation, and the circumstances in which prima facie legitimate behavior may be abusive-although it arguably leaves much scope for interpretation. This article discusses some of the issues raised in these important areas.
It should, however, be noted that the General Court's decision is itself under appeal to the European Court of Justice, so the law will remain uncertain for some time yet.
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Committee on Audit & Compliance
John Charles Thomas, Chair
Leigh A. Pence, Vice Chair
Ann Green Baise
John E. Littel
Christopher M. Little
DeRonda M. Short
Kent B. Erdahl, Director of Internal Audit
Kiersten L. Boyce, Chief Compliance Officer and Title IX/ADA Coordinator
Samuel E. Jones, Vice President for Finance
Anna B. Martin, Vice President for Administration
The Committee on Audit & Compliance shall oversee the Office of Internal Audit, which is charged with the responsibility of auditing William & Mary and Richard Bland College, and shall consider and make recommendations on policy matters pertaining to campus safety and security and risk management. The Director of Internal Audit shall be directly responsible to the Committee on Audit & Compliance in the formation of an annual Audit Plan. The President of William & Mary and the President of Richard Bland College may advise and consult with the Committee on any matter pertaining to internal auditing. The Committee shall perform an annual evaluation of the Director of Internal Audit during the Board's annual meeting for recommendation to the full Board.


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Dress by ELISE RYAN. V-neck front and contrast material to reverse. Concealed zipper at side. Flare, lined skirt. Comes with waist belt. Hand wash recommended. Made of 100% Polyester. Lining of 100% Polyester.
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ESPN College Football reporter Chris Low discusses why Kirby Smart is emerging as a top candidate for the South Carolina head coaching position.
Use a Facebook account to add a comment, subject to Facebook's Terms of Service and Privacy Policy. Your Facebook name, photo & other personal information you make public on Facebook will appear with your comment, and may be used on ESPN's media platforms. Learn more.


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It's Official: Ben Flajnik Is the Next Bachelor!
Sorry, Jennifer Love Hewitt: Ben Flajnik is still looking for Ms. Right, and he's officially landed his own TV series to do it.
As first reported by Us Weekly, Flajnik, 28, is set to star in the next installment of The Bachelor, ABC confirmed on Tuesday. The Sonoma winemaker's next shot at love debuts on ABC in January 2012.
Flajnik was famously rejected by Ashley Hebert on the recently concluded season of The Bachelorette. The buzzed-about hunk even proposed to Hebert, 27, in Fiji before she broke the news that she'd chosen J.P. Rosenbaum instead.
PHOTOS: Where your fave Bachelors are now
"Everyone wants [Ben] to find the woman of his dreams," an insider told Us in AUgust. Hebert, 27, was the first woman Flajnik really opened up to since the death of his father in 2007. "He loved Ashley," said a source.
Flajnik -- who endured an awkward date with Jennifer Love Hewitt last month -- reportedly beat out other Bachelorette also-rans Ames Brown and Ryan Park.
VIDEO: Ouch! Watch Ashley reject Ben
Tell Us: Are you happy Ben F. is the new bachelor?
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Fashion Offenders
Fergie, Sarah Jessica Parker, and Heidi Klum all get an F on this week's Fashion Offenders.Watch Video »
Diva Double Date
Beyonce and Alicia Keys double date with their famous hubbies on today's Celebs Gone Social.Watch Video »
Where Are They?
See what the cast of "American Beauty" is up to today.Watch Video »
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Jennifer Lopez shares an adorable photo of her look-alike daughter, plus more celebritots on social media on today's Celebs Gone Social.Watch Video »
First Pitch
Prince Harry, Jessica Alba and more stars who threw out the first pitch at baseball games.Watch Video »
Aussie Babe
Sofia Vergara poses in a revealing neon bikini while her "Modern Family" castmates hit the beach in Australia on Celebs Gone Social.Watch Video »


text:
Kivik is perhaps best known for it's annual market in July and of course it is a must for tourists. But Kivik Österlen, with its rolling countryside, also has attractions for hiking and swimming along the beaches.
Within a radius of 500 meters from the hostel are several shops including an ICA grocery store, many restaurants and of course the beach. Or do what we usually do when we have checked in all the guests for the day - pack a little pasta salad, some bread and cheese and a good bottle of red wine and wander down to the sea at dusk.


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ACE Fit Share
Browse through a variety of lower and upper chest exercises designed by today's leaders in the health fitness industry. We have strength training exercises for beginner, intermediate and advanced users. These exercises will help you increase the strength and definition of your chest area. If you want more information on chest exercises or strength training of any kind, be sure to check out our Fit Facts section and Ask the Expert column. These chest exercises are also featured in full workout routines in our Workouts section.
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Coffee has lots of proven health benefits, but not everyone enjoys the taste of coffee (without lots of cream and sugar, anyway) or how caffeine makes them feel. The Nutrition Twins offer up four satisfying alternatives to your morning cup of coffee that will leave you...
Too busy for breakfast? The key to starting your mornings off right is planning a healthy breakfast the night before. Here are some healthy and delicious breakfast options that will help jumpstart your metabolism and fuel your body and brain for the morning.
A lot of what we do in life is in front of us, such as using the computer and driving, which eventually results in restricted chest, shoulder and arm flexibility. Improve your posture, increase flexibility and help relieve pain with these variations on standard chest...


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Plugin Bugs item #892049, was opened at 2004-02-06 12:14
Message generated for change (Comment added) made by ezust
You can respond by visiting:
Please note that this message will contain a full copy of the comment thread,
including the initial issue submission, for this request,
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Category: None
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>Status: Closed
>Resolution: Works For Me
Priority: 5
Private: No
Submitted By: Peter D Wilson (dflora)
Assigned to: Nobody/Anonymous (nobody)
Summary: Latex: -include-directory flag
Initial Comment:
I am using TexLive, which does not accept the
-include-directory flag, neither can I change it in
the Consol Commando window.
In lieu of a fix, how can I make the change, surely
these param values are editable?
>Comment By: Alan Ezust (ezust)
Date: 2013-11-28 08:21
This is not a bug but a support request. It seems to have been answered in
the previous comment.
Comment By: Anthony Roy (ant-roy)
Date: 2004-02-26 03:13
Logged In: YES
In the settings tab of the Commando window, set the Include
Directory to an empty string.
Or install the LaTeXTools plugin, and set your preferred
compile, bibtex and viewer command lines through the
options. (If you choose this option, use the 0.5.1 version
from the community site
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I have cleared my cache but I still don't see it.
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Meta Stack Exchange is where users like you discuss bugs, features, and support issues that affect the software powering all 150 Stack Exchange communities.
I assume you mean the main site is stackoverflow. Make sure your email is set correctly on both site profiles.


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Respond to Review of Scrumpy Willow and the Singing Kettle
by Prettyvisitor09
Review: I just ate the vegan breakfast and drank a vegan milkshake there, it was incredible. It was certainly the best vegan breakfast I'd ever tasted! The puy lentils were so tasty, I will certainly be going again ASAP and would recommend it to anyone reasonable prices too. Loved it, so happy to find somewhere to eat in Newcastle town centre too.
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Nick has been a gamer since the 8-bit days and a member of the MTB editorial team since January of 2011. He is not to be interrupted while questing his way through an RPG or desperately clinging to hope against all reason that his Philly sports teams will win any given game he may be watching. Seriously folks, reading this acknowledges that you relieve MTB of any and all legal liability for his actions.Specialty:
Check These Out
Hunt or be Hunted: Primal Carnage: Extinction [Review]
Primal Carnage: Extinction you're either the hunter or the hunted.
Legends, Myths, and the Supernatural Collide in Hard West
Hard West brings turn-based, tactical game play to the weird west.


text:
Jennifer Aniston's new ad for Smartwater. / David Slijper
Jennifer Aniston has been in bed, so to speak, with Smartwater since 2007.
But in her new ad, the brand spokeswoman looks downright dreamy, don't you think?
Shot in Los Angeles at the Stahl House, this Smartwater ad is the first color ad Aniston has done.
(Remember last year's pregnancy spoof for Smartwater? Even that was in black and white.)
The words on this one urge us to "Look up to the clouds" for inspiration. But we're guessing most people are just looking at pretty Jen in bed.
Meanwhile, her fiance Justin Theroux is busy zooming around New York, showing off his guns.
Copyright 2015 USATODAY.com
Read the original story: Jennifer Aniston's in bed with Smartwater


text: So I understand why heated molecules move faster--they have more energy. But, for my example, I'll use a water molecule. A water molecule has a certain density, and that density is more than that of air (which is why water stays in a pot). But when the water is heated to 100 deg. Celsius, it becomes steam. This steam always travels in an upward direction. I'm assuming this is because those H2O molecules have more energy--but why do they always go UP? Why don't they just go in some arbitrary directions? And sorry, I'm not well-versed in Chemistry at all. Actually quite an idiot on the subject. :-( But thanks for any useful input!


text:
Numerous reviews of Donkey Punch, an alternately glossy and loony thriller that debuts at Starz FilmCenter this week, have argued that the opening portions of the film, in which a trio of British party girls vacationing in Spain hook up with a group of randy young sailors on a lavish yacht, are considerably more convincing than the scenes of murder and mayhem that follow. But while the latter sequences do indeed stretch credulity to the snapping point, their pulpy dumbness qualifies as blessed relief, not narrative sin. In the beginning, the women (Nichola Burley, Jaime Winstone and Sian Breckin) are too vapid and their male counterparts (Robert Boulter, Tom Burke, Julian Morris and Jay Taylor) too tiresomely neanderthalic to generate much interest in their doom-laden drugs-and-sex antics. Fortunately, the plot twists that take place after these idiots start to panic lift the film out of its sophisticated torpor, with one death in particular qualifying as laugh-out-loud funny. Both halves of the movie are bad — but only one of them is bad in a good way.
Donkey Punch begins its run at Starz FilmCenter, 900 Auraria Parkway, at 7:30 p.m. on Friday, February 27. Tickets are $9.50, with discounts for students, seniors and Denver Film Society members. Get info at 303-595-3456 or www.denverfilm.org.
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Looking for holiday inspiration? Our Advent and Christmas devotionals are here.
The lessons here given are plain, and likely to benefit those who feel their own ignorance, and their need to be taught. If young people take heed to their ways, according to Solomon's Proverbs, they will gain knowledge and discretion. Solomon speaks of the most important points of truth, and a greater than Solomon is here. Christ speaks by his word and by his Spirit. Christ is the Word and the Wisdom of God, and he is made to us wisdom. (Pr
Next commentary:
Exhortations to fear God and obey parents.
About this commentary:
Matthew Henry's Concise Commentary on the Bible is available in the Public Domain.


text:
|N Seoul Tower (N 서울타워)
|VisitKorea does not guarantee the quality of products or services introduced on its site and is not responsible for any direct or indirect losses resulting from use of said products or services.
|Seoul Tower opened to the public on October 15, 1980 and has since become a major tourist attraction. The 236.7m tower sits atop Namsan Mountain (243m). The observatory offers panoramic views of Seoul and the surrounding areas.
Thirty years and countless visitors later, the structure was renamed 'N Seoul Tower.' The letter 'N' stands for the tower's 'new' look, which resulted from a 15 billion won remodeling project in December 2005. With the new lighting system and changes to the tower's overall color scheme, event coordinators can now decorate the tower for the season or events.
Visitors are encouraged to try the N Grill, Western-style revolving restaurant (one rotation every 48 minutes) and the Sky Restroom (an artfully decorated space). Both offer breathtaking views of the cityscape.
|+82-2-3455-9277, 9288
|N/A (Open all year round)
|Operating Hours
Observatory: 10:00-23:00
Observatory: 10:00-24:00
* Last admission 30 minutes before closing.
* The operating hours are subject to change depending on weather or business schedules.
|Parking Facilities
|Namsan Cable Car Parking Lot
First 30 min: Free for cable car customers
500 won for each additional 10 min
Namsan Park Parking Lot
1 hour 1,300 won
300 won for each additional 10 min
*Please refer to official website for more details.
|Admission Fees
Adults 9,000 won / Children 7,000 won
[Alive Museum]
Adults 12,000 won / Seniors & Children 9,000 won
※ Seniors (ages 65 and more) / Adults (ages 13-65) / Children (ages 3-12)
※ 10% discount for groups (20 people or more). For group reservations, please make an inquiry at +82-2-2034-0669 before visiting.
※ 30% discount for persons with disability (level 1-3) plus one companion / 30 % discount for persons with disability (level 4-6)
※ 30% discount for men of national merit
※ Free admission: Infants (ages under 36 month)
※ Prices indicated for Alive Musuem do not include integrated packages.
|Available Facilities
|[N Seoul Tower]
Lobby: Entrance to observatory, information desk, Alive Museum, N Gift, N Sweet Bar, cafe, nursing room
Plaza 1F - The Best Burger in Seoul, N Terrace, N Gift, ticket booth, Food O'clock
Plaza 2F - The Place Dining (Italian restaurant), roof terrace
Tower 1F - Hancook (Korean Restaurant)
Tower 2F - The Wishing Pond, Sky Restroom, Sky Coffee, N Photo Studio
Tower 3F - Observatory, The BA:NG (Gift shop), Weenybeeny, N Photo
Tower 5F - N Grill (French restaurant)
[Cable Car]
- Operating hours: 10:00-23:00
- Fare:
Individuals (round-trip ticket): Adults 8,500 won / Children & Seniors 5,500 won
Individuals (one-way ticket): Adults 6,000 won / Children & Seniors 3,500 won
Groups (round-trip ticket): Adults 7,000 won / Children & Seniors 4,500 won
Groups (one-way ticket): Adults 5,000 won / Children & Seniors 3,000 won
※ Groups: 30 or more people
※ Inquiry: Daytime +82-2-753-2403 / Nighttime +82-2-757-1308
※ Homepage: www.cablecar.co.kr (Korean, English, Japanese, Chinese)
[Namsan Orumi]
Namsan Orumi is a slanted elevator connecting Namsan Tunnel 3 to Namsan Cable Car.
- Boarding place: In front of the commemorative monument at the entrance of Namsan Tunnel 3.
(2-3 minutes to the cable car)
※ Cable car closed every Monday from 9:00 to 14:00 for standard maintenance check.
※ Cable car will not operate in the case of strong winds and heavy rains.
|Interpretation Services Offered
|* Audio guide, leaflets, pamphlets and maps available in English, Chinese & Japanese
(Audio guide: 3,000 won)
* Group guide: 10 or more people (first-come, first-served basis)
| [Bus - Namsan Circular Shuttle Bus]
1. Namsan Circular Shuttle Bus No. 02
-Take the bus from the closest subway station: Chungmuro Station (Seoul Subway Line 3, 4), Exit 2 (in front of Daehan Cinema) or Dongguk University Station (Seoul Subway Line), Exit 6.
-Interval: every 15 min
-Operating hours: 07:00 – 24:00
2. Namsan Circular Shuttle Bus No. 03
-Take the bus from the closest subway station: Seoul Station, Seoul Square (Seoul Subway Line 1, 4), Exit 9 or Itaewon Station (Seoul Subway Line 6), Exit 4 or / Hangangjin Station (Seoul Subway Line 6), Exit 2.
-Interval: every 20 min
-Operating hours: 07:30 – 23:30
3. Namsan Circular Shuttle Bus No. 05
-Take the bus from the closest subway station: Myeong-dong Station (Seoul Subway Line 4), Exit 3 or Chungmuro Station (Seoul Subway Line 3), Exit 2 (in front of Daehan Cinema).
-Interval: every 15 min
-Operating hours: 07:30 – 23:30
[[Cable Car]
-Boarding point: Myeong-dong Station (Seoul Subway Line 4) Exit 3, walk for about 15 minutes following the street of the right side of the Pacific Hotel. The boarding place should be seen.
-Operating hours: 10:00 - 23:00
Schedules are subject to change. For more details, refer to the official website.
www.nseoultower.co.kr (Korean, English)


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Citrus Magic, Solid Air Freshener, Fresh Citrus, 20 oz (566 g)
By Citrus Magic9 Reviews
Shipping Weight:?1.71 lbs (0.78 kg)
Shipping Weight
The Shipping Weight includes the product, protective packaging material and the actual shipping box. In addition, the Shipping Weight may be adjusted for the Dimensional Weight (e.g. length, width & height) of a package. It is important to note that certain types of products (e.g. glass containers, liquids, fragile, refrigerated or ice packed) will often require protective packaging material. As such, these products will reflect a higher Shipping Weight compared to the unprotected product.
- Product Code: CIM-72196
- UPC Code: 087052721961
- Package Quantity: 20 oz (566 g)
- Dimensions: 5 x 5 x 3.3 in, 1.45 lbs (0.66 kg)
Total: $16.10
Combo Discount: -$1.11
Together: $14.99
Product Overview
- Naturally Absorbs Odors
- New 20 oz Size!
- Ideal for Basements · Closets · Pet Areas · Cars · Smoke · Mold · Mildew
- Is Ideal for ... Auto/RVs · Laundry Rooms · Bathrooms
Long Lasting Dual Action:
- Instantly Eliminates Odors
- Fresh Citrus Scent Fills the Air
Citrus Magic Solid Air Freshener magically absorbs bad odors and freshens the air ... Naturally! Our unique formula uses baking soda, increasing its odor absorbing power. Odors are eliminated and the clean Fresh Citrus scent freshens the air.
Suggested Use
Peel off top label exposing air vents. Place all around the house in the areas you want to keep fresh and odor-free.
Citrus Magic will absorb odors in 350 sq. ft. areas for 8-10 weeks. For larger areas, like basements, use several units evenly spaced. For increased effectiveness, place near circulating air source.
For additional air freshening power, use Citrus Magic Odor Eliminating Spray Air Freshener.
Caution: Keep out of reach of children. May be harmful if swallowed. Avoid placing in high temperature areas. Product may become liquid at temperatures above 115º F.
Water, fragrance, saponified vegetable fatty acid, vegetable-derived emulsifiers, glycerin, salt, citrus and vegetable-derived odor absorbers and baking soda.
iHerb Customer Reviews
I put these in all the clothes cupboards as the clothes get a slight damp smell over time. Great product, great price, refreshing smell. Will be purchasing more in the future.


text: Around lunch time we had drifted into the part of Udine were the University is. Looking for a place to have lunch, and passing over some quick food counters we decided on Il Vapore. The restaurant is on the first floor, the ground floor houses the bar and the kitchen. There was one waiter presiding... read more


text:
The Magic of Seeing Your Search Ad from Justin Sanger at ClickZ probably should have been titled, "The Dirty Little Secret Of Local Search Click Fulfillment." For the past 18 months or so, a variety of new local search packages and programs aimed at small, locally-oriented merchants have sprung up. They've often had a simple pitch. "You'll get clicks!" It's a focus that's alarmed me given that search marketing in general has progressed well past rankings, clicks and into conversion.
Justin explains how the click guarantees may get fulfilled by ads placed well of the regular beaten track of the major search engines. He's not suggesting that the clicks don't convert or that there's fraud going on. Rather, he points out a more basic problem.
Those buying the ads may be small businesses, but they're savvy enough to want to actually see their ads on Google, Yahoo and other major players. When they don't, they get frustrated -- a bad move for a new advertiser audience the industry is trying to attract.


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I picked up a frame with some random parts on it that I am rebuilding with parts I have and I am wondering if it would be possible to mix and match a few campy and shimano components and still get decent shifting?
The frame came with a Shimano 6 speed RD hooked up to a campy 6 speed brifter and 6 speed freewheel (all Triomphe). I have no idea if this worked or not, it's just what was on there. Is it possible that I will be able to get it to work if I build it back up like that?
Also, these is a campy double setup in front (also Triomphe) but the brifter is busted so I need to replace the shifter with something. I have a Shimano 105 double brifter - will I be able to get it to work with the campy cranks and FD?
I know none of this is supposed to be compatible and I've never worked with campy stuff before but my experience with everything else is the less gears there are the more likely things are to work when you mix and match - will this same concept apply to campy/shimano 6 speed bits?


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We were all packed up to leave Calgary and needed to get some brunch. On the drive out we see several signs showing specials at the Elbow River Casino, no strings attached [unlike other casinos that require you to sign into a players reward program or some other hook] so we decided to stop in. I ordered the thai salmon,... More
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[PotUS] Recruitment, and Moving Forward
23 • Dita 2,198, 11:31 • E Publikuar në USA • Debate dhe Analiza Politike
I have an announcement to make, and another announcement. This will hopefully be an interesting article. I've tried to make this term as successful as it can be, and I … lexo më shumë »


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Overall: 4.2 / 5 based on 19 reviews
16 of 19 reviewers would recommend this product to a friend.
Purchase for future generations -
By: MGrimes from Leander, TX
Recently I purchased a Gokey Heirloom Leather Shell Bag for use when I shoot sporting clays. The quality and craftsmanship of this shell bag will ensure that it will be around for many years and passed down to my children. I highly recommend this product without any reservation.
Great shell Bags - below average belt -
By: NautiBuoy from Nova Scotia, Canada
Have purchase several pieces of Bullhide luggage (and love them) & thought this would be similar in quality, I was wrong. Belt is far too big, had to punch 8 more holes to get to fit 40" waist. Should of ordered a Med/Large (my error). As pointed out in several reviews, the belt curls under the weight of shells. I would of paid another $50 to get a more sturdy belt. Pouches are great, stand up well and will last forever. Will need to buy a 1 3/4" - 2" belt and suspect a wading belt will be best option. Bottom line, would recommend to a friend but advise to expect to buy a more sturdy belt.
Half of It Is Great... -
By: Schatzman from New Hampshire
Top 1000 Contributor
Like everyone else has stated, the bags themselves are fantastic but the belt is simply terrible. I purchased these at the Manchester store and noticed right away how terrible the belt was. So I knew what I was getting myself into. I swapped the belt out and I have no major complaints. I use them for trap shooting mostly. One pouch can hold a box of 25 easily. By box I mean i put the actual box in there. I use the second for my empties. Orvis should put these pouches on their higher quality belt.
Overall Disappointing product/service -
By: BigEd101 from N Ireland
I had had many issues simply ordering the holster. HAving spoken to Orvis in both America and England I was able to place the order. I had several issues. Reviews stated that the belt was poor and lightweight for the job it was required to do. I found this also to be the case. A representative suggested that reviews are mostly negative anyway until I pointed out that in fact the overall ratings were good but there were minor issues. I asked if Orvis had payed heed to the reviews and she felt that it take quite a long time for Orvis to respond to genuine criticism. Secondly issues with ordering on line and cost. Because the web page would not let me order I spoke with Orvis UK. I placed the order and discussed size. I was advised that my waist size, 40, would require an XL. This was way too big and one of the reasons I returned the product. I was also charged extra for the larger size. I thought the extra cost for for embossing which I did not want but not the case. I wonder how the charging works as embossing is charged for? I was also promised a phone call to discuss the price but I never receive the call. Orvis claim that I was unavailable. Because I ordered the XL, on advice, I had to return the item as well as the poor quality belt. I was charged postage which Orvis is refunding but only because I complained. The product has great potential but if Orvis is not prepared to listen to its customers, some of whom have been faithful to the company here and abroad for years, then other companies are as keen to sell their products to people like me who are looking for a good honest product.
very nice shell bag and belt -
By: weewa from houston tx
It is hard to find such a nice shell bag without breaking the bank.
Really nice bags, first class -
By: Todd2 from San Diego, Ca.
The Gokey Heirloom leather shell bags are really nice quality bags. They'll last a life time. I wish the belt that the bags came with was the same quality though, the belt needs to be a little larger in diameter, when carrying full bags of shells the belt starts to fold. Overall the product of the bag is great, wish I had bought them earlier in life.
Perfect gift -
By: rjc58 from fredericksburg, VA
I ordered this leather shell holster for my brother as a gift. He is an avid shooter and appreciates quality accessories when goes to the range. He called me shortly after he received it since he put it right to use and loved everything about it. I'm looking forward to the next time we get to shoot together to see his big smile.
Gokey bag -
By: UplandFlyFisherman from Pittsford, NY
bag is nice and sturdy but the belt is thin and stretches under weight of 50 shells. especially the holes. plan on replacing the belt with your own.
Great shell abs for bird hunting -
By: Oldbirdhntr from Piedmont North Carolina
These are exceptionally well made shell bags and I have used them for years. Like others, I found the belt a little light, replaced it with an adjustable Orvis belt, and added a waxed cotton game bag. Normally I carry 28 or .410 shells in the left bag still in their box, which eliminates spillage. I rarely spill any shells from the right bag even though I carry them loose and leave the flap unbuttoned. These bags are classic and a pleasure to use.
By: john50


text: Do You Know This Newly Engaged Couple? [VIDEO] By Joe Kelly July 17, 2012 5:17 AM Share on Facebook Share on Twitter A photographer is looking for a couple captured in a Washington D.C. photo. Please take a look and see if you can help identify this mystery couple. Filed Under: Mystery | Washington D.C. Category: News Share on Facebook Share on Twitter More Leave a comment Send to a friend! Print this page Pin it! Reddit This! Share on Tumblr! Best of Cat Country 107.3 Recommended For You Best of the Web


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realmagick.com The shrine of knowledge.
A selection of articles related to squares.
Original articles from our library related to the Squares. See Table of Contents for further available material (downloadable resources) on Squares.
- Enochian Temples
- Constructing Enochian Temples During the six months beginning November, 1985, I was involved in an extended exploration of the Enochian Tablet of Earth. There was no purpose to the work other than tourism - I merely wanted to see what was there and record it...
Magick >> Enochian
- Enochian Temples: The Lower Temple
- The previous sections dealt with the Temple primarily in its relation to the macrocosmic world. The Servient squares were considered only in their formation as the floor, and were largely ignored otherwise. But they can also be grouped to form altars of the...
Magick >> Enochian
- Popular Oracles and Omens
- I think it would be correct to assume that man has always been anxious to lift a corner of the veil of the future. In this section I've included several popular oracles, omens and superstitions. Some of these might seem a bit ridiculous, but why not consider...
Psychic Abilities >> Divination
- The Transiting Planets
- The transiting Planets are always affecting us whether we choose to be conscious of their influences or not. As they pass through the succeeding houses and signs, they make aspects to other transiting and natal Planets. When a transiting Planet squares or...
Mystic Sciences >> Astrology
- 12 - The Hanged Man
- The card depicts a completely defenseless crucified man, held by the ankh, egyptian symbol of life-force. Everything is taken away from him, all he can do is surrender and trust guidance from within. He has got stuck in his old way of living or thinking, (the...
Tarot Cards >> The Major Arcana
- Colors in Psychology
- "Personality is a mask you believe in." Dr. White If you wish to accomplish change through color then it makes sense to first take a look at your own reactions on colors. First choose your favorite color(s) from the color fields below, next pick out...
Symbology >> Colorology
- Beltane - The Lover's Holiday
- ABOUT BELTANE | RITUAL | FOODS | REFERENCES ABOUT BELTANE Beltane is celebrated on May 1st and is one of the original Celtic festivals, Samhain being the other one. Beltane or May Day is also known as the Lover's holiday. Beltane is pronounced bel-tene, "...
Holidays >> Beltaine
Squares is described in multiple online sources, as addition to our editors' articles, see section below for printable documents, Squares books and related discussion.
Suggested Pdf Resources
- Least Squares
- The term least squares describes a frequently used approach to solving overdeter- The least squares criterion has important statistical interpretations.
- www.mathworks.com
- Partial Least Squares (PLS) Regression.
- Partial Least Squares (PLS) Regression. Hervé Abdi1. The University of Texas at Dallas.
- www.utdallas.edu
- Least Squares Quantization in PCM
- cs.nyu.edu
- Nonlinear Regression and Nonlinear Least Squares
- Nonlinear Regression and Nonlinear Least Squares. Appendix to An R and S- PLUS Companion to Applied Regression. John Fox.
- cran.r-project.org
- Image Deformation Using Moving Least Squares
- faculty.cs.tamu.edu
Suggested News Resources
- Syria denies gatherings at two main squares in Damascus: report
- 27 (Xinhua) -- Syria's state media on Saturday denied that there are any protests or any kind of gatherings at al- Abasseen and Ummayyad squares in Damascus, in contrast to what some "provocative" satellite channels had broadcasted earlier in the day.
- City planners eye Public Square's 'Avenger's' movie makeover
- CLEVELAND -- Cleveland's Public Square has been transformed into a movie double for the bustling beer garden city of Stuttgart, Germany as a shooting scene for the "The Avengers.
- City supports Square businesses, road closure affects parking
- By Emily Hill, email@example.com Despite the closure of an essential road in the downtown area, residents, city officials and even a construction company has banded together to support businesses on the Square.
- Carlos Pena: Yankees Take Pena to Block in Waiver-Wire Squares
- CHICAGO, IL - JUNE 21: Carlos Pena # 22 of the Chicago Cubs is greeted by his teammates after hitting a home run in the fifth inning against the Chicago White Sox on June 21, 2011 at US Cellular Field in Chicago, Illinois.
- Syrian Protesters Want Their Own Tahrir Square
- Activists in Syria have been bemoaning the lack of a central square in the Syrian capital Damascus. Like the Egyptians who have Tahrir Square, they want a central place from where they can launch protests.
Suggested Web Resources
- Squares 2 | Online Games
- 0 squares. evil squares. invincibility.
- www.albinoblacksheep.com
- Square – Accept credit card payments with your mobile phone
- Accept credit card payments anywhere with your iPhone, iPad or Android phone. Download the free Square app to get started.
- squareup.com
- Square (geometry) - Wikipedia, the free encyclopedia
- In geometry, a square is a regular quadrilateral. This means that it has four equal sides and four equal angles (90-degree angles, or right angles).
- en.wikipedia.org
- Squares and Square Roots
- First learn about Squares, then Square Roots are easy. To square a number, just multiply it by itself . Example: What happens when you square -5 ?
- www.mathsisfun.com
- Squares - JeffWu.net
- 0 squares. evil squares. invincibility.
- www.jeffwu.net
Great care has been taken to prepare the information on this page. Elements of the content come from factual and lexical knowledge databases, realmagick.com library and third-party sources. We appreciate your suggestions and comments on further improvements of the site.
Squares Topics
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interstate 80 major cities
tora tora tora production and filming
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Othello - Board Game Club
By playfrog
Open iTunes to buy and download apps.
Othello is a strategy board game for two players, played on an 8×8 uncheckered board. The player's goal is to have a majority of their colored pieces showing at the end of the game, turning over as many of their opponent's pieces as possible.
With this Othello, you can play with a friend who sits next to you or play against your phone.
The artificial intelligence embeded in the game allows a player to play a very easy mode but also much harder and challenging modes.
* Multiple language support: English, Chinese and Japanese
* Customize player name and avatar
* Score tracking and auto player rank
* Easy to learn
* Undo function
* Highlight possible moves
* Great graphics and awesome sound effects
* Play against a friend or the challenging computer on the same device, or play against a friend on two devices connected via Bluetooth
What's New in Version 5.0
Bug fixes and iOS8 compatible.
iPhone Screenshot
- Free
- Category: Games
- Updated: Feb 19, 2015
- Version: 5.0
- Size: 20.9 MB
- Languages: English, Chinese, Japanese
- Seller: Playfrog,Inc
- © Playfrog
Compatibility: Requires iOS 5.1.1 or later. Compatible with iPhone, iPad, and iPod touch.


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It's so easy to get caught up in all of the glitz and glam of engagement rings. Between the sparkly stones and beautiful designs, it's also easy to forget that one ring definitely does not fit all. Finding the right... Read More
Tag Archives: style
Finding just the right boutonniere can be a surprisingly difficult task. You want the groom (and his pals) to have a boutonniere that blends in with the rest of the floral details, but you also know he isn't necessarily looking... Read More
We've gathered some of our favorite seating chart trends to inspire you to design a chart to fit not only your practical needs, but also one that will blend beautifully with the rest of your event! Chalkboard We love the... Read More
For months you've been listening to your engaged friend's wedding plans. In fact, it has even caused you to suffer from a slight case of party planning envy. Now's your chance to have fun selecting a theme and choosing decor.... Read More
Often the most difficult part about registering is narrowing down your requests. Do you want a bubblegum pink mixer or a practical white one? What throw pillows would work best with your sofa? Do those candlesticks look like something the... Read More
When I first heard about this latest trend you could color me cynical. Crop top wedding dresses? Scandal! I just couldn't imagine a version of a crop top wedding dress that would look very matrimonial, let alone elegant. However, I've... Read More
Don't be overwhelmed by the volume of wedding invitation designs available to you out there. Instead, look for a wedding invitation that will match the style of your big day! We've collected several pretty examples to match the most popular... Read More
As the holidays and 2014 become a distant memory, we love to look ahead to see what the next year will have in store for us. As many couples get engaged over the holiday season, one of the first steps... Read More
Save the Date cards are a fun way to announce your wedding and allow your guests to mark their calendars with your wedding date, especially when your guests will need to make specific travel arrangements and book hotel accommodations. Plus,... Read More
As the two of you start building your home together, it's all about finding your style. Here we help you with four popular decor options that are available through Macy's Ultimate Registry Checklist. It's all about selecting what you love... Read More
There's really no way you can adequately thank your bridal party. These ladies talked you out of your dressing room when you were having a major meltdown at the bridal salon, hosted that gorgeous shower, and are wearing those teal... Read More
From princess cut engagement rings to oval stones and halo settings, there are so many different kinds of beautiful engagement rings out there. In Volume IV of mywedding The Magazine we take a closer look at what makes an engagement... Read More
Using monochromatic wedding details can make an impactful color statement at your event. You don't need a million colors to have a gorgeous palette–you really only need one. From flowers to cocktails, you can make your wedding color carry through... Read More
From pink earrings to the perfect blush comb, have we got a round-up of pink wedding accessories for you! And I am going to try very hard not to drop any Pretty in Pink references, but I can't make any... Read More
Brides are stepping away from tradition when it comes to matching color and styles for the bridal party these days. It is no longer necessary to have just one color and style. While traditional matching bridesmaids and groomsmen are still... Read More
The best part about registering? Selecting all of the items you are going to use when you host friends and family at your new home. What better time than a party or weekend visit to show off your new-found couple... Read More


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Mavericks Photos
Photos: Marion swats away balls at rim, Blair pillar in the lane, Mavs beat Magic
Photo: Ron Jenkins/MCT
Orlando Magic shooting guard E'Twaun Moore (55) gets past Dallas Mavericks defenders in the second half of an NBA preseason game against the Orlando Magic in Dallas, Texas, on Monday, October 14, 2013. (Ron Jenkins/Fort Worth Star-Telegram/MCT)
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WASHINGTON -- This week, Americans observed the seventh anniversary of the worst attack on U.S. soil in our nation's history, with memorial services for the 3,000 of our countrymen who perished Sept. 11, 2001. This week's commemorations also should remind us that the failure to act against a clear and present danger can have extremely dire consequences. That's what happened for eight years with Osama bin Laden's al-Qaida movement. Unfortunately, now it's happening again, with Tehran.
In February 2006, I interviewed Dr. David Kay, an internationally respected arms expert, for a Fox News' "War Stories" documentary on the Manhattan Project. Kay headed the U.N. inspection team that uncovered Saddam Hussein's nuclear weapons program after the 1990-91 Gulf War. During the course of our discussion, I asked Kay whether we should be concerned about Iran's nuclear ambitions. His response was a warning:
"We should be worried about it for two reasons. A) They're on a course that will, in fact, finally at some point produce nuclear weapons, and secondly, they have a regime which does not appear to play by the normal rules of stable international behavior. They speak of destruction. They speak of chaos, wiping Israel off the face of the earth. They also are the leading state sponsor of terrorism not exactly what I view as a secure holder of the nuclear genie."
Last December, a highly controversial U.S. National Intelligence Estimate concluded that the Iranians had put their nuclear weapons program "on hold" -- perhaps as early as 2003. But this week, in the September/October issue of The National Interest, Kay proffered yet another caution: "It looks as if Iran is 80 percent of the way to a functioning nuclear weapon."
The evidence Kay cites for the progress Tehran is making in developing an atomic weapons arsenal ought to be alarming to policymakers in Washington. His sobering assessment "that Iran is pushing toward a nuclear-weapons capability as rapidly as it can" ought to inspire concerted action by the U.S. and our allies to prevent such an outcome. Yet American and European officials seem content to rely on "voluntary" sanctions imposed by the United Nations.
This week, the U.S. departments of State and Treasury announced that the U.S. assets of the Islamic Republic of Iran Shipping Lines and more than a dozen of its subsidiaries have been frozen. According to Stuart Levey, undersecretary of the Treasury for Terrorism and Financial Intelligence, IRISL has engaged in a broad "pattern of deception and fabrication that Iran uses to advance its nuclear and missile programs." Treasury officials also are urging maritime insurers to stop providing coverage for Iranian vessels, including Tehran's fleet of petroleum tankers.
Oliver North is a nationally syndicated columnist, the host of War Stories on the Fox News Channel, the author of the new novel Heroes Proved and the co-founder of Freedom Alliance, an organization that provides college scholarships to the children of U.S. military personnel killed or permanently disabled in the line of duty. Join Oliver North in Israel by going to www.olivernorthisrael.com.
"Your Republican Uncle": DNC debuts new website to help slow-witted young liberals talk politics with family on Thanksgiving | Allahpundit
Obama 2013: Assad must go. Obama today: Hopefully Assad won't run for president again. | Allahpundit


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What with all the temp records being established, I'm wondering how hot it has to get before you just die if you stand outside. That is, what's the hottest that an ordinary, healthy person can stand assuming no cooling and shade? 130 F, 140 F? Are we already beyond it in the Australian Outback? When do parts of… »
The popularity of various kinds of monsters can be tracked by looking at IMDB keywords attached to movies: http://restivo.nfshost.com/zombies/. Zombies have just recently overtaken ghosts! The same idea applied to lots of other topics: http://babelniche.wordpress.com/2012/10/03/what-are-movies-about/. The most… »


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Us' Programming Guide: What to Watch This Spring
Miss The Real Housewives of New Jersey? Can't wait for more Keeping Up With the Kardashians? Some of this season's hottest new shows share DNA with many currently off-air fan favorites. As you outline your spring TV viewing schedule, check out UsMagazine.com's guide to what to watch in terms of reality TV.
IF YOU LIKE KEEPING UP WITH THE KARDASHIANS…THEN WATCH AUDRINAFormer Hills star Audrina Patridge, 25, takes center stage with her eponymous VH1 series. "This is Audrina 360. You are inside her life as it unfolds," executive producer Jeff Olde tells Us of the reality show. Like E!'s Kardashians, lively family members -- including her mom Lynn -- serve as costars. "Everyone lets their guard down," Olde says. Adds Patridge: "People are going to relate. We're raw and real." (Premieres April 17, 9 p.m.)
VIDEO: Watch a sneak peek of Audrina
IF YOU LIKE HUNG…THEN WATCH GIGOLOSShowtime's sexually explicit Thursday night reality show one-ups HBO's male-prostitute drama by profiling five actual Las Vegas escorts. "The gigolo world is exciting but emotionally taxing," executive producer Jay Blumenfield tells Us. In one episode, easygoing Jimmy broods over revealing his career to visiting pals. (Airs Thursdays at 11 p.m.)
IF YOU LIKE THE REAL HOUSEWIVES OF NEW JERSEY…THEN WATCH MOB WIVESTable-flipping times 10! On VH1's new Sunday night series, four allegedly mob-connected New York City frenemies are at one another's throats -- literally. Mob Wives "gives a glimpse into a world America has been fascinated by for decades," executive producer Jennifer Graziano explains. A must-see highlight: January's biggest-ever FBI mob sweep. (Premieres April 17 at 8 p.m.)
VIDEO: Spring TV news and previews
IF YOU LIKE AMERICAN IDOL…THEN WATCH THE VOICELike Idol, NBC's Tuesday night singing competition has starry-eyed hopefuls, a voting audience and big names (such as Christina Aguilera) doling out advice. Instead of judging, the stars -- including Blake Shelton, Adam Levine and Cee Lo Green -- mentor the contestants. "We want to make them shine!" Aguilera enthuses. (Premieres April 26 at 9 p.m.)
Tell Us: Which new series will get a season pass on your DVR?
By Allison Corneau for UsMagazine.com. For more Channel Surfing, click here.
Get more Us! Follow us on Twitter, Friend us on Facebook, Subscribe to Us Weekly
Most Watched on Wonderwall
Fashion Offenders
Fergie, Sarah Jessica Parker, and Heidi Klum all get an F on this week's Fashion Offenders.Watch Video »
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Beyonce and Alicia Keys double date with their famous hubbies on today's Celebs Gone Social.Watch Video »
Where Are They?
See what the cast of "American Beauty" is up to today.Watch Video »
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Jennifer Lopez shares an adorable photo of her look-alike daughter, plus more celebritots on social media on today's Celebs Gone Social.Watch Video »
First Pitch
Prince Harry, Jessica Alba and more stars who threw out the first pitch at baseball games.Watch Video »
Aussie Babe
Sofia Vergara poses in a revealing neon bikini while her "Modern Family" castmates hit the beach in Australia on Celebs Gone Social.Watch Video »


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All Mountain Snowboards - MensAll Mountain Snowboards at ProBoardshop are in unbelievable stock with the most affordable price listings. Unbeatable prices with fast free shipping make this store completely jaw-dropping. Save up to 40% on selected gear, but don't wait! These popular All Mountain Snowboards are shipped out just as fast as they arrive to our warehouses.
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- Size: 149-151.5
- Color: Purple
- Price: 220.00 - 249.99
All Mountain Snowboards
Burton Burden SnowboardReg: $449.95 On Sale: $247.95
Size: 150cm, 154cm, 157cm
DC Tone SnowboardReg: $400.00 On Sale: $236.95
Size: 149cm, 153cm, 156cm, 159cm