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Agents with Bancorp South came to the Hattiesburg Police Department and reported that on 10/21/2013 and unidentified black male came into the Westwood Square location and made a withdrawal from a Bancorp South customer's account who had his wallet stolen while attending the Ole Miss / LSU football game. The suspect forged the withdrawal slip and presented the victim's ID card for the withdrawal.
Hattiesburg police are investigating a forgery and identity theft, and are seeking the public's help in identifying the suspect.
Bancorp South officials reported the fraud to police today, according to Hattiesburg Police Department incident reports.
The victim's wallet was stolen, and the black male suspect depicted in the security camera footage ...


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Category:Parks and open spaces in West Sussex
From Wikipedia, the free encyclopedia
This category has the following 2 subcategories, out of 2 total.
- ► Country parks in West Sussex (1 P)
- ► Gardens in West Sussex (13 P)
Pages in category "Parks and open spaces in West Sussex"
The following 8 pages are in this category, out of 8 total. This list may not reflect recent changes (learn more).

subset: commoncrawl


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found a new home!
Plenty of my friends are looking
for one too. Find a pet to adopt.
I am already neutered, housetrained, up to date with shots, not good with kids, and not good with dogs.
Act quickly to adopt Bit. Pets at this Rescue Group may be held for only a short time.
Bit, a Union Domestic Mediumhair cat was adopted! Here's how you can benefit by looking at adoption as an option to buying a Domestic Mediumhair for sale in Union, or seeking a Domestic Mediumhair cat from a breeder in Union.


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Hi Guys!Could you give informations and opinions about this lens?...Is it similar,better or almost better than the beautiful Canon FD 200 F4?Thank you very much!:)
Printable View
Hi Guys!Could you give informations and opinions about this lens?...Is it similar,better or almost better than the beautiful Canon FD 200 F4?Thank you very much!:)
Hi guys!...0 Answers?why?
Sort of an uncommon line, old. That said I shoot the Contax/Yashica line and though I have not used that particular lens many of the Yashicas lenses are not bad at all. Especially 1 or 2 stops from fully open. Just do not pay much.
I read the thread and I have a bunch of Yashica ML lenses, but no Telephoto lenses so I cannot comment.
Here's a user's review in German if that helps you any:
I don't have this ML lens myself, but conventional wisdom has it that, apart from the far-famed ML 500 mirror tele, the best MLs are on the short side, that is, from the superb macro lenses down to the ultra-wides and most anything in between. I once had an ML 2.8/135mm and swapped it for a Tokina prime with identical specifications, and it proved to be much sharper than the Yashi. If I were you I'd also consider getting an RMC Tokina 80-200 f4.0 manual zoom lens.
This is a pretty simple lens and it's likely good - I wouldn't expect it to be markedly better or worse than any other Japanese name-brand 200/4 of its era. It will very likely be better than zooms (excepting professional zooms) at 200mm though.
I've owned the ML 200/4 (not sure if it was the C version or normal) but I've never used the FD 200 so I can't compare them. I didn't like the ML 200 as it simply wasn't very sharp, wide open, and was OK stopped down but so are all lenses. I certainly wouldn't consider it a worthwhile lens and I wouldn't ever recommend one. Maybe I had a mediocre one but TBH I found most ML lenses (of the several I've owned over the years) to be average, with the odd exception.
Thank you for your support.
for JJphoto:Do you remember the positive exception from the Yashica ML serie ?
Thank you very much
At present I have the ML 50/1.4, ML 50/2, ML 55/2.8 Macro, ML 24/2.8. I use them on a Canon 5D2, don't tell anyone... I've had the ML 21/3.5, ML 200/4 which I used to use on transparency film and B+W.
The 50/2 is rubbish. Just rubbish. It makes a decent body cap.
The 50/1.4 is OK in that it renders very much like the Contax 50/1.4 but the ML is less sharp at every aperture and it suffers significantly from purple fringing/CA wide open (on digital, it might not be a problem on film). You can get much better 50/1.4's for the same or less money but why not just save a bit for the Contax and have one of the best 50/1.4's even compared to modern lenses.
ML 50/1.4 at F1.4
The ML 55/2.8 is in my bag most of the time and I use it quite a bit. There are no purple fringing or significant CA issues with it. It's a very good lens, I would certainly recommend it, but I suspect that macros are just an easy lens to design/build and I don't think I've ever heard of a bad macro lens. I suspect it's not in the same league as 'better' macros from Contax but it's also a very cheap lens.
ML 55/2.8 all at F2.8
The ML 24 is quite good and I have no real complaints about it. I just don't use it enough to comment much more, but I would certainly recommend it at the right price. I must like it because I sold one a very long time ago and then bought another one back again, but I just don't use that focal length much these days.
The ML 21/3.5 has a reputation for being a fine lens. Mine was not very good wide open (and I'll bet they are all the same) and needed to be stopped down at last one stop and preferably 2 at which point it was extremely sharp. I would certainly recommend it but not at current prices.
Having said/written all that, don't buy any of it (except maybe the ML 55/2.8). Save your money and buy the equivalent Contax lens if you can. The Contax coatings are superb and contribute significantly to improving contrast and controlling flare in general. They work perfectly on Yashica bodies so there's no excuse to NOT use them except for their cost. Good luck.
PS, don't tell anyone I'm shooting digital!
My ML 50/2 and DSB 50/1.9 lenses were terrific so I'm guessing the 50/2 that you describe has taken a fall or something.


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Summit Entertainment announced today that Red 3 is already in the works, and it will be written by Red and Red 2 scribes Jon and Erich Hoeber.
Red 2 will be coming to theaters soon (July 19th), but Summit is already planning a Red 3. Red 3 will be produced by Lorenzo Di Bonaventura and Mark Vahradian.
We will keep you posted when more news of Red 3 drops, but I have a feeling we won't hear anything new until after Red 2's box office results are in.


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Discover a selection of top forums shaboom wayne on the internet. Come to share your passion on forums shaboom wayne and meet other fans of shaboom wayne. Then, why don't you create your own forum of shaboom wayne ?
Free forum : jeepuporshutup. com
jeep, road, jeepuporshutup, wheeling, indiana, fort, #wayne, allen, county, northeast, northeastern, off-road, diesel, bogger, bogging, trec, t.r.e.c


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2001 Ford Mustang • 2WD Manual • 140,000 miles
I have a 2001 ford mustang and it will not start. What should I try doing to it before I purchase a new fuel pump?
February 14, 2011.
February 14, 2011.
Get a helper disconnect a sparkplug wire or 2 and ground it to the engine at least 3/16 away from ground -have helper crank engine over-do you have a snapping blue spark? If so-you have a fuel related problem, Do you hear the fuel pump come On when you turn key on? If not check fuel pump fuse and fuel pump relay if so, check the fuel pressure to rule out the fuel filter/fuel pump/pressure regulator and listen to the injector/s are they pulsing or hook up a noid light. No snapping blue spark continue to troubleshoot the ignition system-power input to the coil/coil packs, coil's resistances, distributor pick-up coil, ignition control module, cam and crank sensors and computer Note: If it doesn't apply disregard it.
Feb 14, 2011.
Feb 14, 2011.
Where is and how do I replace a fuel pump on a 1996 Taurus GL?
1 answer • 1996 Ford Taurus • 170,000 miles
Fuel pump replacement on a 1998 jeep Grand Cherokee Laredo. The tank is removed need help from there. thanks
1 answer • 1998 Jeep Laredo


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Tip: How to Cook the Sweetest Sweet Potatoes
Getting the sweetest sweet potatoes isn't about picking out the ripest or most promising potatoes in the bunch. Nope! Rather, a little culinary magic trick will transform your toughest tubers into delicious treats. Here's how!
If you like your sweet potato casserole extra sweet, all you have to do is bake the sweet potatoes low and slow!
Raw sweet potatoes are mostly starchy fibers, but they also contain an enzyme that will break down the starch into sugar at certain temperatures. According to food scientist Harold McGee, this enzyme happens to work best when the sweet potato is between 135°F and 170°F.
Logically, the longer you can keep the sweet potato within this temperature range, the more starch will get converted to sugar. Steaming and boiling cook the sweet potato too quickly, but baking it in the oven at 350°F or lower is perfect. Sweet potatoes are done when they're soft all the way through.
If you're using the sweet potatoes in something like a casserole or a pie, you can bake the whole potatoes ahead of time and keep them for several days before using them in your recipe.
Give it a try!
(Oh, and by the way, that photo up top is from Pithy & Cleaver, where you can find this recipe: Sweet Potato Purée with Pecan Streusel. Yum!)
Related: Thanksgiving Sides: 5 Alternatives to Sweet Potato Casserole
(Image: Flickr member Maggie Hoffman licensed under Creative Commons)


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Are you Nicholas V. Reo?Claim your profile
Publications (47)161.74 Total impact
Article: The networks of human gut microbe–metabolite associations are different between health and irritable bowel syndrome[Show abstract] [Hide abstract]
ABSTRACT: The goal of this study was to determine if fecal metabolite and microbiota profiles can serve as biomarkers of human intestinal diseases, and to uncover possible gut microbe-metabolite associations. We employed proton nuclear magnetic resonance to measure fecal metabolites of healthy children and those diagnosed with diarrhea-predominant irritable bowel syndrome (IBS-D). Metabolite levels were associated with fecal microbial abundances. Using several ordination techniques, healthy and irritable bowel syndrome (IBS) samples could be distinguished based on the metabolite profiles of fecal samples, and such partitioning was congruent with the microbiota-based sample separation. Measurements of individual metabolites indicated that the intestinal environment in IBS-D was characterized by increased proteolysis, incomplete anaerobic fermentation and possible change in methane production. By correlating metabolite levels with abundances of microbial genera, a number of statistically significant metabolite-genus associations were detected in stools of healthy children. No such associations were evident for IBS children. This finding complemented the previously observed reduction in the number of microbe-microbe associations in the distal gut of the same cohort of IBS-D children.The ISME Journal advance online publication, 30 January 2015; doi:10.1038/ismej.2014.258.The ISME Journal 01/2015; 9(8). DOI:10.1038/ismej.2014.258 · 9.30 Impact Factor
Article: 126 Altered Gut Microbial Energy and Metabolism in Children With Non Alcoholic Fatty Liver Disease[Show abstract] [Hide abstract]
ABSTRACT: Obesity is becoming the new pediatric epidemic. Non-alcoholic fatty liver disease (NAFLD) is frequently associated with obesity and has become the most common cause of pediatric liver disease. The gut microbiome is the major metabolic organ and determines how calories are processed, serving as a caloric gate and contributing towards the pathogenesis of NAFLD. The goal of this study is to examine gut microbial profiles in children with NAFLD using phylogenetic, metabolomic, metagenomic and proteomic approaches. Fecal samples were obtained from obese children with or without NAFLD and healthy lean children. Stool specimens were subjected to 16S rRNA gene microarray, shotgun sequencing, mass spectroscopy for proteomics and NMR spectroscopy for metabolite analysis. Children with NAFLD had more abundant Gammaproteobacteria and Prevotella and significantly higher levels of ethanol, with differential effects on short chain fatty acids. This group also had increased genomic and protein abundance for energy production with a reduction in carbohydrate and amino acid metabolism and urea cycle and urea transport systems. The metaproteome and metagenome showed similar findings. The gut microbiome in pediatric NAFLD is distinct from lean healthy children with more alcohol production and pathways allocated to energy metabolism over carbohydrate and amino acid metabolism, which would contribute to development of disease. © FEMS 2014. All rights reserved. For permissions, please e-mail: email@example.com Microbiology Ecology 02/2014; 91(2). DOI:10.1093/femsec/fiu002 · 3.57 Impact Factor
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ABSTRACT: Studies aimed at identifying serum markers of cellular metabolism (biomarkers) that are associated at baseline with aerobic capacity (VO(2max)) in young, healthy individuals have yet to be reported. Therefore, the goal of the present study was to use the standard chemistry screen and untargeted mass spectrometry (MS)-based metabolomic profiling to identify significant associations between baseline levels of serum analytes or metabolites with VO(2max) (77 subjects, age range 18-35 years). Use of multivariable linear regression identified three analytes (standard chemistry screen) and twenty-three metabolites (MS-based metabolomics) containing significant, sex-adjusted associations with VO(2max). In addition, fourteen metabolites were found to contain sex-specific associations with aerobic capacity. Subsequent stepwise multivariable linear regression identified the combination of SGOT, 4-ethylphenylsulfate, tryptophan, γ-tocopherol, and α-hydroxyisovalerate as overall, sex-adjusted baseline predictors of VO(2max) (adjusted R (2) = 0.66). However, the results of the stepwise model were found to be sensitive to outliers; therefore, random forest (RF) regression was performed. Use of RF regression identified a combination of seven covariates that explained 57.6 % of the variability inherent in VO(2max). Furthermore, inclusion of significant analytes, metabolites and sex-specific metabolites into a stepwise regression model identified the combination of five metabolites in males and seven metabolites in females as being able to explain 80 and 58 % of the variability inherent in VO(2max), respectively. In conclusion, the evidence presented in the current report is the first attempt to identify baseline serum biomarkers that are significantly associated with VO(2max) in young, healthy adult humans.Arbeitsphysiologie 11/2012; 113(5). DOI:10.1007/s00421-012-2555-x · 2.19 Impact Factor
Conference Paper: Localized Deconvolution: Characterizing NMR-based Metabolomics Spectroscopic Data using Localized High-throughput Deconvolution[Show abstract] [Hide abstract]
ABSTRACT: The interpretation of nuclear magnetic reso-nance (NMR) experimental results for metabolomics studies requires intensive signal processing and multivariate data analysis techniques. Standard quantification techniques at-tempt to minimize effects from variations in peak positions caused by sample pH, ionic strength, and composition. These techniques fail to account for adjacent signals which can lead to drastic quantification errors. Attempts at full spectrum deconvolution have been limited in adoption and development due to the computational resources required. Herein, we develop a novel localized deconvolution al-gorithm for general purpose quantification of NMR-based metabolomics studies. Localized deconvolution decreases average absolute quantification error by 97% and average relative quantification error by 88%. When applied to a 1 H metabolomics study, the cross-validation metric, Q 2 , improved 16% by reducing within group variability. This increase in accuracy leads to additional computing costs that are overcome by translating the algorithm to the map-reduce design paradigm.International Conference on Bioinformatics & Computational Biology, Las Vegas, Nevada; 07/2012
Article: Comparative Metabolomic and Genomic Analyses of TCDD-Elicited Metabolic Disruption in Mouse and Rat Liver[Show abstract] [Hide abstract]
ABSTRACT: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) elicits a broad spectrum of species-specific effects that have not yet been fully characterized. This study compares the temporal effects of TCDD on hepatic aqueous and lipid metabolite extracts from immature ovariectomized C57BL/6 mice and Sprague-Dawley rats using gas chromatography-mass spectrometry and nuclear magnetic resonance-based metabolomic approaches and integrates published gene expression data to identify species-specific pathways affected by treatment. TCDD elicited metabolite and gene expression changes associated with lipid metabolism and transport, choline metabolism, bile acid metabolism, glycolysis, and glycerophospholipid metabolism. Lipid metabolism is altered in mice resulting in increased hepatic triacylglycerol as well as mono- and polyunsaturated fatty acid (FA) levels. Mouse-specific changes included the induction of CD36 and other cell surface receptors as well as lipases- and FA-binding proteins consistent with hepatic triglyceride and FA accumulation. In contrast, there was minimal hepatic fat accumulation in rats and decreased CD36 expression. However, choline metabolism was altered in rats, as indicated by decreases in betaine and increases in phosphocholine with the concomitant induction of betaine-homocysteine methyltransferase and choline kinase gene expression. Results from these studies show that aryl hydrocarbon receptor-mediated differential gene expression could be linked to metabolite changes and species-specific alterations of biochemical pathways.Toxicological Sciences 09/2011; 125(1):41-55. DOI:10.1093/toxsci/kfr262 · 3.85 Impact Factor
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ABSTRACT: The interpretation of nuclear magnetic resonance (NMR) experimental results for metabolomics studies requires intensive signal processing and multivariate data analysis techniques. A key step in this process is the quantification of spectral features, which is commonly accomplished by dividing an NMR spectrum into several hundred integral regions or bins. Binning attempts to minimize effects from variations in peak positions caused by sample pH, ionic strength, and composition, while reducing the dimensionality for multivariate statistical analyses. Herein we develop an improved novel spectral quantification technique, dynamic adaptive binning. With this technique, bin boundaries are determined by optimizing an objective function using a dynamic programming strategy. The objective function measures the quality of a bin configuration based on the number of peaks per bin. This technique shows a significant improvement over both traditional uniform binning and other adaptive binning techniques. This improvement is quantified via synthetic validation sets by analyzing an algorithm's ability to create bins that do not contain more than a single peak and that maximize the distance from peak to bin boundary. The validation sets are developed by characterizing the salient distributions in experimental NMR spectroscopic data. Further, dynamic adaptive binning is applied to a 1H NMR-based experiment to monitor rat urinary metabolites to empirically demonstrate improved spectral quantification. KeywordsNMR–Metabolomics–Binning–Quantification–Dynamic programmingMetabolomics 06/2011; 7(2):179-190. DOI:10.1007/s11306-010-0242-7 · 3.86 Impact Factor
Article: A generalized model for metabolomic analyses: Application to dose and time dependent toxicity[Show abstract] [Hide abstract]
ABSTRACT: As metabolomic technology expands, validated techniques for analyzing highly dimensional categorical data are becoming increasingly important. This manuscript presents a novel latent vector-based methodology for analyzing complex data sets with multiple groups that include both high and low doses using orthogonal projections to latent structures (OPLS) coupled with hierarchical clustering. This general methodology allows complex experimental designs (e.g., multiple dose and time combinations) to be encoded and directly compared. Further, it allows for the inclusion of low dose samples that do not exhibit a strong enough individual response to be modeled independently. A dose- and time-responsive metabolomic study was completed to evaluate and demonstrate this methodology. Single doses (0.1–100mg/kg body weight) of α-naphthylisothiocyanate (ANIT), a common model of hepatic cholestasis, were administered orally in corn oil to male Fischer 344 rats. Urine samples were collected pre-dose and daily through day-4 post-dose. Blood samples were collected pre and post-dose to assess indices of clinical toxicity. Urine samples were analyzed by 1H-NMR spectroscopy, and the spectra were adaptively binned to reduce dimensionality. The proposed methodology for NMR-based urinary metabolomics was sensitive enough to detect ANIT-induced effects with respect to both dose and time at doses below the threshold of clinical toxicity. A pattern of ANIT-dependent effects established at the highest dose was seen in the 50 and 20mg/kg dose groups, an effect not directly identifiable with individual principal component analysis (PCA). Coupling the pattern found by the OPLS algorithm and hierarchical clustering revealed a relationship between the 100, 50 and 20mg/kg dose groups, suggesting a characteristic effect of ANIT exposure. These studies demonstrate that the use of a metabolomics approach with flexible binning of 1H spectra and appropriate application of multivariate analyses can reveal biologically relevant information about the temporal metabolic perturbations caused by exposure and toxicity. KeywordsNMR metabolomics–High dimension categorical data–Adaptive binningMetabolomics 06/2011; 7(2):206-216. DOI:10.1007/s11306-010-0246-3 · 3.86 Impact Factor
- Gastroenterology 01/2011; 140(5). DOI:10.1016/S0016-5085(11)60477-0 · 16.72 Impact Factor
Conference Paper: Cloud-based Map-Reduce Architecture for Nuclear Magnetic Resonance based MetabolomicsProceedings of the 7th Microsoft Research eScience WorkshopProceedings of the 7th Microsoft Research eScience Workshop; 01/2010
Article: Characterization of H-1 NMR spectroscopic data and the generation of synthetic validation sets[Show abstract] [Hide abstract]
ABSTRACT: Common contemporary practice within the nuclear magnetic resonance (NMR) metabolomics community is to evaluate and validate novel algorithms on empirical data or simplified simulated data. Empirical data captures the complex characteristics of experimental data, but the optimal or most correct analysis is unknown a priori; therefore, researchers are forced to rely on indirect performance metrics, which are of limited value. In order to achieve fair and complete analysis of competing techniques more exacting metrics are required. Thus, metabolomics researchers often evaluate their algorithms on simplified simulated data with a known answer. Unfortunately, the conclusions obtained on simulated data are only of value if the data sets are complex enough for results to generalize to true experimental data. Ideally, synthetic data should be indistinguishable from empirical data, yet retain a known best analysis. We have developed a technique for creating realistic synthetic metabolomics validation sets based on NMR spectroscopic data. The validation sets are developed by characterizing the salient distributions in sets of empirical spectroscopic data. Using this technique, several validation sets are constructed with a variety of characteristics present in 'real' data. A case study is then presented to compare the relative accuracy of several alignment algorithms using the increased precision afforded by these synthetic data sets. These data sets are available for download at http://birg.cs.wright.edu/nmr_synthetic_data_sets.Bioinformatics 09/2009; 25(22):2992-3000. DOI:10.1093/bioinformatics/btp540 · 4.98 Impact Factor
Article: Development of analytical methods for NMR spectra and application to a 13 C toxicology study[Show abstract] [Hide abstract]
ABSTRACT: Metabolomics offers the potential to assess the effects of toxicants on metabolite levels. To fully realize this potential, a robust analytical workflow for identifying and quantifying treatment-elicited changes in metabolite levels by nuclear magnetic resonance (NMR) spectrometry has been developed that isolates and aligns spectral regions across treatment and vehicle groups to facilitate analytical comparisons. The method excludes noise regions from the resulting reduced spectra, significantly reducing data size. Principal components analysis (PCA) identifies data clusters associated with experimental parameters. Cluster-centroid scores, derived from the principal components that separate treatment from vehicle samples, are used to reconstruct the mean spectral estimates for each treatment and vehicle group. Peak amplitudes are determined by scanning the reconstructed mean spectral estimates. Confidence levels from Mann–Whitney order statistics and amplitude change ratios are used to identify treatment-related changes in peak amplitudes. As a demonstration of the method, analysis of 13C NMR data from hepatic lipid extracts of immature, ovariectomized C57BL/6 mice treated with 30 μg/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or sesame oil vehicle, sacrificed at 72, 120, or 168 h, identified 152 salient peaks. PCA clustering showed a prominent treatment effect at all three time points studied, and very little difference between time points of treated animals. Phenotypic differences between two animal cohorts were also observed. Based on spectral peak identification, hepatic lipid extracts from treated animals exhibited redistribution of unsaturated fatty acids, cholesterols, and triacylglycerols. This method identified significant changes in peaks without the loss of information associated with spectral binning, increasing the likelihood of identifying treatment-elicited metabolite changes.Metabolomics 06/2009; 5(2):253-262. DOI:10.1007/s11306-008-0148-9 · 3.86 Impact Factor
Article: Biomarkers of Exposure to Toxic Substances: Volume 4: Metabonomics Biomarkers to Liver and Organ Damage[Show abstract] [Hide abstract]
ABSTRACT: In this study we examined the urinary metabolite profiles from rats following a single exposure to the kidney toxicants D-serine, puromycin, hippuric acid and amphotericin B at various doses, and as a function of time post-dose. In toxicology, such dose-time metabonomics studies are important for an accurate determination of the severity of biological effects, and for biomarker identification that may be associated with toxicity. The metabonomics analysis yielded a dose-response curve in principal component analysis space, and was able to detect exposure to D-serine and puromycin at much lower doses than standard clinical chemistry measures. Additionally, characteristic features in the urinary metabolite profiles could be ascertained as a function of dose. The results showed common features and some unique features in urinary metabolite profiles when analyzed by NMR and LC-MS, respectively.
Article: Metabonomics Approach to Biomarker Discovery, Volume VI: Dose and Time Response of Liver Toxicant[Show abstract] [Hide abstract]
ABSTRACT: The work described in the following report was initiated to investigate the possibility of using novel biotechnologies for the discovery, down-selection, and pre-validation of biomarkers of toxic substance effects within the warfighter prior to health and operational performance decrement. Using the biotechnology of metabonomics, this effort focused on using nuclear magnetic resonance (NMR) spectroscopy and ultra pressure liquid chromatography mass spectrometry (UPLC/MS) for identification of liver-selective toxic effects following exposure to a known hepatotoxicant (alpha-naphthylisothiocyanate; ANIT) that induces cholestasis. Urine samples were analyzed by NMR spectroscopy and UPLC/MS and the data processed and analyzed by principal component analysis, linear discriminant analysis, and hierarchical clustering analysis. NMR- and UPLC/MS-based urinary metabonomics were sensitive enough to detect ANIT-induced toxic effects with respect to both dose and time. Understanding the cellular response to chemical exposure at the molecular level will not only facilitate the elucidation of the mechanism of chemical toxicity, but also allow accurate prediction of chemical toxicity and phenotypic outcome. Ultimately, this will lead to the identification of novel biomarkers for rapid monitoring and prediction of health hazards to the warfighter associated with chemical exposure.
Article: Characterization of
Article: Gaussian binning: A new kernel-based method for processing NMR spectroscopic data for metabolomics. Metabolomics, 4, 261-272[Show abstract] [Hide abstract]
ABSTRACT: In many metabolomics studies, NMR spectra are divided into bins of fixed width. This spectral quantification technique, known as uniform binning, is used to reduce the number of variables for pattern recognition techniques and to mitigate effects from variations in peak positions; however, shifts in peaks near the boundaries can cause dramatic quantitative changes in adjacent bins due to non-overlapping boundaries. Here we describe a new Gaussian binning method that incorporates overlapping bins to minimize these effects. A Gaussian kernel weights the signal contribution relative to distance from bin center, and the overlap between bins is controlled by the kernel standard deviation. Sensitivity to peak shift was assessed for a series of test spectra where the offset frequency was incremented in 0.5Hz steps. For a 4Hz shift within a bin width of 24Hz, the error for uniform binning increased by 150%, while the error for Gaussian binning increased by 50%. Further, using a urinary metabolomics data set (from a toxicity study) and principal component analysis (PCA), we showed that the information content in the quantified features was equivalent for Gaussian and uniform binning methods. The separation between groups in the PCA scores plot, measured by the J 2 quality metric, is as good or better for Gaussian binning versus uniform binning. The Gaussian method is shown to be robust in regards to peak shift, while still retaining the information needed by classification and multivariate statistical techniques for NMR-metabolomics data.Metabolomics 08/2008; 4(3):261-272. DOI:10.1007/s11306-008-0117-3 · 3.86 Impact Factor
Conference Paper: Gaussian binning for processing NMR spectroscopic data for metabolomics[Show abstract] [Hide abstract]
ABSTRACT: In many metabolomics studies, NMR spectra are divided into bins of fixed width to reduce the number of variables for pattern recognition techniques and to mitigate effects from variations in peak positions. Using this method, shifts in peaks near bin boundaries can cause dramatic quantitative changes in adjacent bins. Here we describe a quantization technique using a Gaussian kernel that incorporates overlapping bins to minimize these effects. Sensitivity to peak shift was assessed for a series of test spectra where the offset frequency was incremented in 1 Hz steps. For a 4 Hz shift within a bin width of 24 Hz, the error for uniform binning increased by 150% while the error for Gaussian binning increased by 50%. Using a urinary metabolomics dataset (from a toxicity study) and principal component analysis (PCA), we showed that the information content in the quantified features was equivalent for Gaussian and uniform binning methods.U.S. Army Center for Health Promotion and Preventive Medicine 11th Annual Force Health Protection ConferenceU.S. Army Center for Health Promotion and Preventive Medicine 11th Annual Force Health Protection Conference; 01/2008
Conference Paper: A Proposed Statistical Protocol for the Analysis of Metabolic Toxicological Data Derived from NMR Spectroscopy.[Show abstract] [Hide abstract]
ABSTRACT: Nuclear magnetic resonance (NMR) spectroscopy is a non-invasive method of acquiring a metabolic profile from biofluids. This metabolic information may provide keys to the early detection of exposure to a toxin. A typical NMR toxicology data set has low sample size and high dimensionality. Thus, traditional pattern recognition techniques are not always feasible. In this paper, we evaluate several common alternatives for isolating these biomarkers. The fold test, unpaired t-test, and paired t-test were performed on an NMR-derived toxicological data set and results were compared. The paired t-test method was preferred, due to its ability to attribute statistical significance, to take into consideration consistency of a single subject over a time course, and to mitigate the low sample, high dimensionality problem. We then grouped the resulting statistically salient potential biomarkers based on their significance patterns and compared results to several known metabolites affected by the tested toxin. Based on these results, we present a statistical protocol of sequential t-tests and clustering techniques for identifying putative biomarkers. We then present the results of this protocol applied to a specific real world toxicological data set.Proceedings of the 7th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2007, October 14-17, 2007, Harvard Medical School, Boston, MA, USA; 01/2007
Conference Paper: Comparison of Statistical Techniques for the Analysis of Metabolic Toxicological Data Derived from NMR Spectroscopy[Show abstract] [Hide abstract]
ABSTRACT: Nuclear magnetic resonance (NMR) spectroscopy is a non-invasive method of acquiring a metabolic profile from biofluids. Identifying biomarkers from these profiles may provide keys to the early detection of exposure to a toxin. Two common features of NMR data sets are small sample size and a large number of variables (i.e. high dimensionality). The high dimensionality arises from each sample spectrum being divided into a large number of regions, each of which is a dimension. Pattern recognition techniques can then be used to identify biomarkers from a data set that consists of metabolic profiles from a small number of samples. A typical first step of this analysis is to individually identify responsive spectral regions, followed by associating these regions with metabolites and biomarkers. In this paper, we evaluate several common alternatives to identify responsive regions, including the fold test, paired t-test, and logistic regression. Further, when performing these types of analyses, the issues of multiple-comparisons and false positive rates must be addressed. We compare several corrections for these issues including the Bonferroni, Holm's, Westfall and Young, permutation, and bootstrap methods. The results of these statistical tests in combination with the multiple-comparison corrections were compared on both a simulated data set and an NMR-derived toxicology data set. Based on these results, we present a statistical protocol for determining putative biomarkers, designed to mitigate the low sample size, high dimensionality, and false positive issues associated with NMR data.Proceedings of the Ohio Collaborative Conference on BioinformaticsProceedings of the Ohio Collaborative Conference on Bioinformatics; 01/2007
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ABSTRACT: An increasingly important issue in force protection is the toxicology associated with toxic chemical and mixture exposure at uncharacterized deployed sites. Current methods for determining or monitoring toxic exposures to the warfighter in their working or living environment are not adequate to prevent serious health effects. Deployed personnel may be exposed to toxic chemicals as a result of industrial accidents, intentional or unintentional activities of enemy or friendly forces or sabotage. Rapid risk assessment of these scenarios requires the development of new testing methods. In order to prevent serious injury to the deployed warfighter exposed to toxic substances and to minimize mission degradation due to environmentally related adverse health effects, novel human monitoring methodologies that provide near real-time detection of potential toxic injury must be developed. It is necessary to devise methodologies that will predict or identify exposure of personnel to low concentrations of harmful substances before they cause harm to an individual. It is also important to identify methodologies that are relatively non-invasive, which could include collection of urine, blood, saliva or epithelial cells from humans. Emerging biotechnologies, such as toxicogenomics, proteomics and metabonomics will be investigated for their effectiveness to identify toxic effects upon the warfighter before they can induce a reduction in health and/or operational performance or before they can induce a disease process that would not manifest for several years.
- [Show abstract] [Hide abstract]
ABSTRACT: The antioxidant capabilities of phosphatidylethanolamine plasmalogen (PlsEtn), in vivo, against lipid peroxidation were investigated via acute phosphine (PH(3)) administration in rats. Oxidative stress was assessed from measures of malondialdehyde and various enzyme activities, while NMR analyses of lipid and aqueous tissue extracts provided metabolic information in cerebellum, brainstem, and cortex. Brainstem had the highest basal [PlsEtn], and showed only moderate PH(3)-induced oxidative damage with no loss of ATP. The lowest basal [PlsEtn] was observed in cortex, where PH(3) caused a 51% decrease in [ATP]. The largest oxidative effect occurred in cerebellum, but [ATP] was unaffected. Myo-inositol+ethanolamine pretreatment attenuated all PH(3) effects. Specifically, the pretreatment attenuated the ATP decrease in cortex, and elevated brain [PlsEtn] in the cerebellum, nearly abolishing the cerebellar oxidative effects. Our data suggest a high basal [PlsEtn], or the capacity to synthesize new ethanolamine lipids (particularly PlsEtn) may protect against PH(3) toxicity.Neurochemical Research 06/2006; 31(5):639-56. DOI:10.1007/s11064-006-9061-7 · 2.59 Impact Factor
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Dropletby Valerie Bee
Choose from a variety of frame styles, colors and sizes to compliment your favorite Society6 gallery, or fine art print - made ready to hang. Fine-crafted from solid woods, premium shatterproof acrylic protects the face of the art print, while an acid free dust cover on the back provides a custom finish. All framed art prints include wall hanging hardware.
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Most people have headaches on and off throughout their
lives. In general, they can be dealt with easily with over-the-counter pain
relievers and lifestyle changes. However, a doctor should assess any frequent
or severe headaches. You should also see a doctor if the pattern of your
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If you're seeing a doctor about headaches, it's probably
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you may want to ask.
Medication overuse is a big problem for people with
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associated with medication overuse. Some of the more powerful painkillers used
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Your prescribed medication should offer prompt relief from
headache symptoms. If it does not, talk to your doctor. Depending on the
medication, you may be able to try another dose. Your doctor may also prescribe
a backup medication.
If you have frequent medication failures, you may need
to switch to a different drug. Not all headache medications work for everyone,
and it can take time to find the drug that will work best for you.
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The Christian County Commission approved $8,100 in spending for three sites on the James River to be monitored for storm water runoff.
As a Municipal Separate Storm Sewer Systems (MS4) designated community, Christian County is required by law to conduct stormwater runoff monitoring.
Planning and Zoning Administrator Todd Wiesehan says his office lacks the resources to do the monitoring on an in-house basis. ...


text:
Mary McDade of Rockford was promoted from independent wine consultant with WineShop at Home to team leader, then group leader. The direct-sell company conducts in-home or in-office wine tastings with wines from California.
Mary McDade of Rockford was promoted from independent wine consultant with WineShop at Home to team leader, then group leader. The direct-sell company conducts in-home or in-office wine tastings with wines from California.
What do you do? Basically, I bring the California wine country to you.
All wines available are boutique- or artisan-labeled wine, which means they are not available anywhere but through me or WineShop at Home. We also have personalized or custom-labeled wines, corporate gifts and every wine accessory you can think of.
What's new with WineShop at Home? Is it looking for more consultants in the area? I'm always looking for wine consultants to join my team.
There are only about 60 wine consultants in Illinois, with only four in the Rockford area, so there's plenty of room for growth and expansion.
Who could do your job? Anyone who loves to get to know people and can talk in front of a group. No wine education is required, just friendly, outgoing personalities.
How can others interested in a career such as yours learn more? They can call me at 815-222-1394 about career opportunities, but wine consulting is really a learn-as-you-go process. Wine Spectator offers a course at a discount for all WineShop consultants that can be taken at your own pace.
Consultants receive a "cheat sheet," or consultant tasting notes, from the winemaker with every bottle of wine.
You get the information about the vintage, appellation (where it comes from), aromas, flavors and, most importantly, food pairings. I also train novices and give them loads of support.
Other than this job, what was your favorite job and why? One of my favorite jobs was in a bank, investing in jumbo CDs and federal funds. I loved playing with other people's money.
You would never find me leaving this field to: Work on computers. Too much aggravation.
The ideal workday for you: Having a tasting and having someone join my team.
The best way to unwind after work is: Sit on my deck with my feet up and an excellent glass of wine from WineShop at Home in my hand. Today it's a yummy pinot noir from Sonoma.
Staff writer Kathi Edwards may be reached at 815-987-1364 or email@example.com.
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John Hendron is an instructional technologist serving teachers and students in a K-12 setting in central Virginia. John is author of the book (2008) RSS for Educators: Blogs, Newsfeeds, Podcasts, and Wikis in the Classroom, published by ISTE.
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Newcastle Upon Tyne hotels
What travelers to Newcastle Upon Tyne are saying
Nifty Newcastle
Experience some of Britain's most exciting nightlife and cultural hotspots by booking your next holiday at one of the many fine hotels in Newcastle Upon Tyne. This thriving city on the River Tyne in north-eastern England has a fascinating history, which can be discovered by touring such wonders as the St. Nicholas Cathedral and ruins of the Hadrian Wall. Famous for its vibrant club scene, get ready to party at such hot spots as the Digital Nightclub. Pack your bags and grab your dancing shoes! Book your stay in Newcastle Upon Tyne accommodation exclusively with HotelClub to take advantage of free membership and exclusive club benefits, like free Wi-Fi, breakfasts, and 7% back on your bookings.
Experience the city's unique personality by strolling through Grainger Town, a quaint Victorian neighbourhood in the heart of the city, which includes the Grainger Market, and the charming Grey Street where you can shop and stop for fine English tea. A visit to Newcastle should certainly include a tour of an authentic medieval fortress such as the moated Tynemouth Castle and Priory. Yearning for a pint of ale? Soccer fans can support their team with the rowdy celebrants at the Sunderland Football Club or catch a performance at the Metro Radio Arena where some of the biggest names in the industry have performed.
Connecting flight service to the Newcastle International Airport is available from most major European cities. From the airport, take either the Tyne and Wear Metro, a bus, a taxi, or rent a car to reach your Newcastle Upon Tyne accommodation. While you can choose to get around the city by foot, most visitors prefer to use the inexpensive, reliable local metro system.
Recommended hotels
1 Sleeperz Hotel Newcastle
15 Westgate Road Map
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the property places you at the heart of the city's multiple attractions, with easy access to them all as one of the more centrally-located hotels in Newcastle. Close to Newcastle central station,... More
Good city base
2 The County Hotel
Neville Street Map
Superfast unlimited FREE WiFi
The County Hotel creates an inviting fusion of old and new with up-to-date facilities and services housed in a Victorian-listed architecture. This Newcastle hotel offers travellers a cosy retreat... More
Overnight stay with my daughter
3 Tune Hotel Newcastle
Proctor House, 23-29 Side Map
Stay 2 nights Save 10%
Located in the heart of the city and just over 5 minutes walk from Newcastle Central railway station, Tune Hotel Newcastle really is ideally positioned for partygoers and tourists alike. This... More
4 Royal Station Hotel
Neville Street Map
The Royal Station Hotel Newcastle upon Tyne is located in the heart of the city centre close to attractions such as the O2 Academy and Newcastle Cathedral, as well as shopping amenities in nearby... More
This is a good hotel
5 Copthorne Hotel Newcastle
The Close, Quayside Map
Early Bird - save 15%
The Copthorne Hotel Newcastle is excellently placed for those either on vacation or business, with its Quayside location overlooking the River Tyne. The property is a short walk to the 'Castle' an... More
long weekend break
6 Hotel Indigo NEWCASTLE
2/8 Fenkle Street Map
Hotel Indigo Newcastle entices travellers to beautifully designed interior and tastefully decorated spaces set in the Newcastle city centre. Located close to architectural and cultural attractions,... More
7 Jurys Inn Newcastle
Scotswood Road Map
Advance Purchase Rates
Featuring luxurious accommodation as well as a wide variety of travel enhancing services, this property is an ideal destination for an enjoyable as well as a wonderful vacation. GeneralGuests... More
8 Holiday Inn Express NEWCASTLE - METRO CENTRE
Clasper Way,Swalwell Map
Park & Fly- Includes up to 15 days of parking
The Holiday Inn Express Newcastle Metro Centre is the ideal choice of accommodation for both holidaymakers and business travelers, being just five kilometres from the city centre and close to major... More
9 Ramada Encore Newcastle-Gateshead
Hawks Road Map
Save 10% on your stay
A newly built hotel minutes from the historic Newcastle Quayside and The Sage Conference venue, Ramada Encore Newcastle Gateshead is ideal for both business travellers and those looking to explore... More
10 Sandman Signature Newcastle Hotel
Gallowgate Map
Advance Purchase Rates!
Whether in Newcastle Upon Tyne for business or leisure, travellers find an ideal base at Sandman Signature Newcastle Hotel. This chic and modern hotel delivers stylish and comfortable... More
Great hotel in a great city
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Asics Gel Blur33 2.0 – Our Take
- By Matt
- April 24, 2012
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Our Tweet With a new upper designed to move more freely with your foot, the Asics Gel Blur33 2.0 furthers its mission of being flexible and nimble. (View Men's Gel … Continue Reading →
Asics Gel Excel33 – Our Take
- By Matt
- January 12, 2012
- No Comments
The 33 collection by Asics is fast expanding (the Instinct33 trail shoe comes out in less than a month), so as fast as Asics keeps servin' 'em up, we're going … Continue Reading →
Introducing Asics 33
- By Matt
- December 29, 2011
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OK, so we kinda dropped the ball on announcing this one. Things have been a little hectic since the first Asics 33 shoe, the Gel Blur33, went up on our … Continue Reading →


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Member Since: September 20, 2012
[72] November 18, 2015 at 11:18pm
Everyone must consider: Trump/Cruz ticket and realize No one will accomplish everything so fast!!
Let Trump get our immigration straightened out, Work on getting jobs back for American workers .
We all know he's quasi-conservative but that's why Cruz is VP, to help Donald along.
I want a pledge for one term from Trump and then Cruz for 8 years
Carson HHS
In reply to ScottBytes's comment on the story We Asked Michelle Malkin If Donald Trump Would Make Good President. She Had This to Say
[12] November 19, 2015 at 12:27am
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[10] November 19, 2015 at 2:14am
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[7] November 19, 2015 at 2:32am
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[1] November 19, 2015 at 11:05pm
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November 21, 2015 at 10:19am
Indagila responded:
[16] October 9, 2015 at 8:27am
And this is why this country has lost! Where are the freedom loving kick ass Americans? Give me freedom or give me death? How about a box of Ding Dongs and an IPOD.
March 24, 2014 at 7:55pm
Nice Job Sally! My thoughts exactly. It's a no-brainer!
March 21, 2014 at 12:31pm
February 2, 2014 at 8:22pm
It was the referee's fault! They're supposed to call the flip before being handed the coin! Duh!
In reply to adoptedlevite's comment on the story Here's Joe Namath's Hilarious Botched Coin Toss at the Super Bowl
February 2, 2014 at 10:24am
The only place that seems fitting would be rikers island
In reply to the story It Begins: Search For Obama Presidential Library Site Is Officially Underway
January 12, 2014 at 9:13pm
No way, I'd bet 20%. It's a fact that conservative people are more patriotic. Look who's destroying the country. Liberals!
January 4, 2014 at 11:14am
When will we stand? Is their a George Washington around today? Sadly, NO. Patriots of today have to be willing to lose their fortune, their family, and their life for freedom. Are there any takers?
December 31, 2013 at 10:48pm
Just wait another 30 years and the left will be pushing this type of behavior as a civil rights issue. Trying to mainstream the freaks of our society.
December 31, 2013 at 10:22am
its a none issue. File the permit. Case solved. There has to be rules in a society and this is very reasonable to file a permit before erecting any sign.
In reply to the story Church Ordered to Remove 'Support Our Troops' Sign
December 31, 2013 at 10:27am
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December 27, 2013 at 9:04am
I like the Giants, anyway.
In reply to the story Within 30 Seconds It's Obvious This Argument Over Football on an Atlanta Train Won't End Well
December 27, 2013 at 9:19am
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December 27, 2013 at 9:02am
All in favor for cyclists paying extra taxes for that little bike lane. If they don't want to pay, hit the sidewalk. Shouldn't be in the road with 2 ton vehicles anyway. With their little spandex and alien helmets.
In reply to the story Bike Hike: Why Chicago Considered a Bike Tax, and Why It's Not Alone
December 25, 2013 at 7:07pm
Was that the live in boyfriend? Where the hell did he come from? Oh Boy!
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December 24, 2013 at 8:53am
Even if she gets caught some liberal judge will give her one year probation. Take justice into your own hands.
December 24, 2013 at 8:35am
That's the reason I couldn't find any Balsam Trees this season.
In reply to the story Popular Christmas Trees See Decline Due to 'the Bug That Ate Christmas'
December 20, 2013 at 10:19pm
And people make fun when I don't let my kid go on school field trips. Sorry, I don't trust these clowns!
December 20, 2013 at 8:45am
None of the children practiced the song in front of the family before the concert? How come everyone was so surprised?
In reply to the story What This School Did to 'Silent Night' Isn't Going Over Well With Some Parents
December 20, 2013 at 9:40pm
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December 3, 2013 at 1:59pm
u nailed it.
December 3, 2013 at 1:53pm
They will never take people's faiths from them no matter how hard they try.
December 1, 2013 at 4:54pm
Duke will beat FSU. Sorry to break the bad news to everyone. They won't even make the national championship.
In reply to the story Florida State Seminoles Now No. 1 in AP Poll After National Title Race Shake Up
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West Genesee's boys lacrosse team spent much of last week in intense practice mode.
The Wildcats'only game on Thursday was a 32-2 romp over Utica Proctor, serving as the team's 10th win in a row.
Getting all the hard work done early, WG had 17 unanswered goals in the first quarter alone, an average of a goal every 42 seconds. By the second period, everyone on the Wildcats' roster was seeing long-awaited playing time.
That allowed Ian Farley to earn five goals and two assists, with Ryan Tinklepaugh getting four goals and two assists and Brandon Dzonkowski posting two goals and five assists.
Dylan Donahue (five goals, three assists) had the most points as Corey Herrington and John Glesener each had three goals and three assists. Tim Barber added two goals and two assists as Dan Ginestro also scored twice.
Matt Schattner, Chris Murphy, Connor Khammer, Sean Biggie and Jake Sutherland took turns scoring, with Tim McMahon adding three assists and Casey Schattner getting two assists.
A day later, WG took a bigger step toward a possible top seed in the Section III Class A playoffs without having to do anything.
Fayetteville-Manlius, 13-0 at the time, lost 8-6 to Corcoran, meaning that, when the Hornets meet the Wildcats in Thursday night's regular-season finale in Camillus (two days after a game with Rome Free Academy), that no. 1 seed could be at stake.
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Mechanism favored by Daly to control population growth is as follows –
According to the mechanism put forward by Daly, a nation can stabilize its population over the long run by establishing a scheme under which each individual in the country would be entitled to produce only one child.
However, entitlement is transferrable. This means that if a person does not want to produce any child he or she can sell his or her entitlement to others who can utilize that entitlement to produce more than one child.
Due to this scheme, each member of the current population would be able to replace himself or herself and this will equate the number of births and number of deaths and thus population stability could be achieved or in other words population growth would be controlled.
Advantages of above stated mechanism are as follows –
1. As certificates are fully transferable it does not compel a family to maintain a particular family size, they can have the size as they want by arranging the required certificates.
2. As per this system, each individual is entitled to produce only one child but there is no restriction on the individual to have no child at all as well. Thus, those viewing parenting as unnecessary activity could sell their certificates easily.
3. This scheme works on the principle of equating births with death by allowing each person to produce only one child and this means that he or she would be replaced by his or her offspring and thus through this scheme stable population could be maintained for eternity.
Disadvantages of above stated mechanism are as follows –
1. This system is very complex and expensive to implement. Considerable expenditure has to be incurred on ensuring compliance.
2. This system will interfere with the sentiments of various population groups divided on religious and racial lines. Many religions consider birth of child as God's will and thus do not permit any restriction on such natural activity.
Moreover, many minorities – groups have above average birth rates and these groups could see such mechanism as a step to limit their population and thus could raise substantial social conflict.
It would be appropriate to implement this policy now in United States because population growth rate in United States is already at desired level as well as due to multi – racial and ethnic population this mechanism could generate social unrest.
However, this policy could be implemented in those countries that have very high birth rate such as Bangladesh where land area is very insufficient in holding the rising population and thus vast majority of population has to live without basic amenities. Apart from this, danger of global warming are also impacting the population leaving in coastal areas in such countries and thus immediate steps to stabilize the population or to control population growth are much needed and therefore such mechanism could act as crucial and game changer for such countries.


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Internet and Catalog Retail
Company Overview of A Book Company, LLC
Company Overview
A Book Company, LLC, doing business as ecampus.com, sells new and used textbooks, trade books, and college emblematic and Greek apparel online for men and women in the United States. It offers electronics, computers, and gifts. The company's technology allows users to market products and services to educational, corporate, and online content providers. It serves students and campus communities. The company was founded in 1999 and is based in Lexington, Kentucky. As of 05/28/1999, A Book Company, LLC is a subsidiary of DeVito/Verdi.
2415 Palumbo Drive
Lexington, KY 40509
United States
Founded in 1999
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A Book Company, LLC Key Developments
A Book Company, LLC Presents at OASIS: Montgomery Summit, Mar-05-2014 09:30 AM. Venue: Fairmont Miramar Hotel & Bungalows, 101 Wilshire Boulevard, Santa Monica, California, United States.
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DRUGS ISSUE: Why I couldn't handle being legal
DRUGS Personally, I'll smoke any dried-up old horseshit you hand me. I don't care. Brown buds, flat buds, wet seedy buds, leaves, stems, branches, even stuff that's already been smoked. You got it, let's roll it.
But I'm also not stupid: pricey gorgeous buds are the best. The tight-purple supernugs have the best smell and the best taste; they are the ultimate gateway to the total marijuana experience. On the other hand, top-shelf Prada buds will fuck you up, financially and otherwise. A dab will definitely do you.
Except at my house. If there's weed anywhere near me, I'll smoke it right up. I don't care how sacred the bud is, or even if I had to scalp a hippie just to pay for it. I am a high-energy, compulsive, scatterbrained cat-lady freak-out type who isn't a major boozer, thank God. So I'm basically the perfect candidate for chain-spliffing. And I don't have a problem with that, in case the church people were wondering. I need my weed and I need it to be abundant and cheap. That's why being a legal stoner smoked me dry.
It took me about three months in the fully legit scene to finally realize that my zero cash flow was entirely the weed's fault. Oh, of course, of course: weed doesn't smoke people; people do. I know all that. But I'm telling you, sister––you need to get a load of this dispensary weed. It will blow your mind and bring you to your knees (and don't bother getting up, honey, because you'll have to blow a lot of stoners to make your rent at these rates). The buds at the pot clubs are so purple, so crystal-y and seductive that it's not offensive in the least to admit they were asking for it — for me to smoke every last one of them, that is. Like Jeffrey Dahmer, I couldn't help myself.
No, the pressure of constant availability was simply too much. I couldn't deal with all that convenience. Three blocks away was just too close. Realistically, the pot club would need a moat filled with cannibals and a legion of snipers with perfect aim to keep a person like me away. And imagine — I am just one Roberta Seawhore among many. I was there every other day, talking weed sass with the staff, sampling this, sampling that, always walking out with at least two to three kinds of Cannabis Cup–level bud products and paraphernalia. Long gone were the silly days of yore when I'd have to go through lazy stoner drug mules, who would maybe show up six days later, if ever, with a few scraps of pot-related plant parts that crawled directly out of a witch's humid crotch. Ga. How plebeian.
So who did I think I was with my fancy-ass buds, anyway — the pope? I'm the kind of broad who shops flip-flops on the Payless sale rack––and now I'm some ganja quality-control expert? Please. "But it's medicine," I reminded myself daily. "You legally need to smoke an enormous amount of papal-quality weed, Roberta. That's why the nice pot-doctor lady prescribed you the EZ Vape2––because you are sick. You have insomnia, dude. Because of your very critical medical-marijuana-necessitating crazy-head condition, you not only deserve the city's sweetest buds, you simply must have them, 24/7, even if it makes you homeless. Relax, marijuana is good for you."
Here's what I learned: Pot clubs are perfect for yuppies who posses a freakish sense of self-control. Everyone else is too low budge.
Which is exactly why, one foggy new-moon morning, I looked deep into my dark Persephone soul and mustered the courage to do the unthinkable: I set fire to my pot card. A few bittersweet tears of relief (mixed with intense pangs of regret and panic) elbowed their way out my left eye as I watched that pretty little pot card burn in the cat dish. Sigh. Heavy is my heart under the weight of the world. Then I rolled a fat one.
Also from this author
In loving remembrance of Michael
After I quit the social networking site, I woke up with a pep in my step, as if I'd just retired after 70 years of service at a meat-packing plant, with a huge marijuana, cat, and vibrator pension in the Bahamas


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I've met some very interesting people as a result of using a visibly old camera in public. The first person stories of old related to photography are often interesting. I'll take a few boring/curious conversations along with the really interesting first person history. It's sort of the same deal with old cars.
I think I'm a better listener than talker, and many strangers are thrilled to find a listener.


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Ruined my lunch!
This is why we can't have nice things.
are you guys on crack? her body looks AMAZING..flat stomach big ass and big boobs..you both are either jealous whores or fruity men.
You forgot: no brain, high maintenance
No, we just don't want to be on THAT pissed-on crack. If Kanye's hitting it makes him a man, then I'm proud to be an entire fruit salad.
NO the TRUTH is she is a pathetic narcissist and has allowed K to turn her into a CHEESY CARTOON. I pity the fool.
T wannabe, her mother turned her, along with the rest of her uterine droppings, into a CHEESY CARTOON long before Kanye came along. She was not deluded or conned into it, she was a willing participant So stop making excuses for her and quit blaming it on some Kanye-come-lately.
The fact that he happens to love his Cheetos in a big-ass bag is another story.
I agree, calling her fat or ugly only means 2 things…these people are either jealous females or gay men.
She's not naturally ugly, she puts a lot of effort into looking like the grease-paint wearing, fat-assed, butt-crack flashing, shameless whore you see undeniably in the photos above.
It's a shame this girl is such a lazy ass, have her worked out she would have had an incredible body,.
From this angle she does look good.
This the money shot, her ass looks great haters lol
Just eat her butthole already, Lola
Okay, snark break. That's a great angle.
she is gross and getting worse with every pic
Karının götü bu açıdan muazzam görünüyor, o ne kıvrım öyle, "hey ben buradayım diyor sanki"
I agree with Lola, I don't give a damn I'd have to dick her down.


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2811 N Stone Ave
Tucson, AZ 85705
At corner of Stone & Glenn
Thursday (show)
Monday 9:00am - 6:00pm
Tuesday 9:00am - 6:00pm
Wednesday 9:00am - 6:00pm
Thursday 9:00am - 6:00pm
Friday 9:00am - 6:00pm
Saturday 9:00am - 2:00pm
Sunday closed (hide)
At corner of Stone & Glenn
Billboard - The latest coupons and news on this business!
Excellent Customer Service & Competitive Prices.
Serving the Tucson area for over 30 years.
|MON 9:00am - 6:00pm
|TUE 9:00am - 6:00pm
|WED 9:00am - 6:00pm
|THURS 9:00am - 6:00pm
|FRI 9:00am - 6:00pm
|SAT 9:00am - 2:00pm
|SUN closed
Category: Car Customizing|Auto Repair|Auto Parts
Service Area: Serving: Tucson AZ
Service: Engine Service, Transmission Repairs, Carburetor Repair
Product: Brake Parts, Auto Electrical Parts, Car Engines, Radiator Parts, Auto Supplies, Clutches
Specialty: Domestic Auto Parts, Antique Auto Parts
Specialty: Custom Auto Performance
Vehicle: SUV Customizing
great place
by ol' ride dude , 06/24/2012
the guys are always helpful, I live on the eastside of town but never hesitate to make the drive over to Don's to pick up whatever parts I need for my 64 chevy


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Vengeance Weapons (Spoilers, maybe)
View Single Post
July 4 2013, 12:29 PM
Re: Vengeance Weapons (Spoilers, maybe)
Oh, that's trivial. Kirk is not a real person, he's a collection of people depicted by non-likeminded writers. Any and all morals are present there for that reason - 78 episodes is plenty enough for that.
As for personal ailments, I tend to find myself disgusted by people who not only mistake TOS for a progressive and liberal show, but argue that the ultraconservative values displayed therein define progressive and liberal in any context. Ridiculing the open militarism of the show is a healthy antidote to that, at least for my half of the problem.
Finally got to see the movie, BTW. And yes, it does appear as if there's a S31 agent or sympathizer aboard every Starfleet ship there, making it quite plausible that these would stumble onto Khan eventually.
Timo Saloniemi
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Shout out if you have any problems or questions about the mousse.
P&Q: top-secret chocolate mousse
by betsyp on November 5, 2012 in problems and questions
Post Author
This post was written by betsyp who has written 256 posts on French Fridays with Dorie.
4 Responses to "P&Q: top-secret chocolate mousse"
This was an epic fail for me :-( Still can't figure out where it went wrong.
I am hoping to see lots of lovely desserts this week…
anderlani1 November 6, 2012 at 7:42 AM #
This makes me sad, Cher. I've made it a bunch of times, and it's one of my faves. Don't think I'll be making it this week, as I have no electric mixer–stand, hand, or otherwise, and I'm too lazy to whisk that thing into submission with brute strength. Wish yours came out better!
tammycirceo November 8, 2012 at 4:29 PM #
I was rushing and didn't let my eggs come to room temperature before whisking the yolks with the melted chocolate. You can probably guess what happened: they seized up the chocolate! Room temperature is key!! (Room temperature whites will also beat fluffier.)
I salvaged it a bit and did up with four custard bowls after mixing in the egg whites, but that was a lesson in frustration. I have more eggs out coming to room temperature … the recipe is simple enough to try a second time for better results.
saralkeefe81 November 8, 2012 at 7:00 PM #
I did the same thing. I managed to save them and get a decent mousse going, but I'm not entirely sold. It was too rich for me. Husband loved it though!
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Design by Paul Tippett
Lemon Regular Fit size info
Figure flattering and fab, our womens tee features a fitted silhouette and complimentary neckline. Its versatile and comfy look is perfect for stylin' up, stylin' down, or stylin' any super cool outfit.
Vibrant Yellow Regular Fit size info
This is one of the chosen designs from the Toy Story Design Challenge.


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No Speccy.....but we have seen you on a donkey.


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This is a remake of the original TV production made in the 70's. The cast is better, and a bigger budget makes for better effects. The story is slightly different but just as good. Read morePublished 7 months ago by Gawaine Caldwater Ross
A friend of mine told me about this movie. I remember watching it. I did remember some of it, however seeing it again is always a treat.Published 10 months ago by the libertarian
Wow - I'm really surprised at all the negative reviews so I thought I should write my own. I LOVE this movie. I have read the book and it's different, but not totally. Read morePublished 14 months ago by Laura Jinn
I can only assume that most reviewers are so emotionally attached to the original work of fiction that they are clouded by their own imaginations. Read morePublished 19 months ago by Lamb and Martyr
I saw this great movie years ago and have been wanting to get a copy of it for my library!Published on August 23, 2013 by JESSE L. PITTMAN
I am a fan of the original 1980 version and also read the book. I knew this was going to be different, which meant I went into this with an open mind. Read morePublished on May 23, 2013 by J. C. M. Bannerman
the pictures of the future and the underground house are tremendous. don't miss it! lisa bonet was a treat for the eyes.Published on May 18, 2013 by Saleem Pernath


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UFO Mothership La Roques August 2007 - CGI?
- Uploaded by Grey on Aug 17, 2007
- Views: 324
This ones supposed to be from Los Roques, the similarities to the Haiti Video are pretty striking, though this one shows a huge Mother Ship. It's actually pretty freaky. Originally posted on YouTube by manbird12000


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What is more dangerous than the drug introduced to viewers and Starling City residents on last night's new episode of Arrow?
The drug DEALER, that's what.
And we'll meet that dangerous individual on next Wednesday's "Vertigo," a mysterious villain named The Count and played by Seth Gabel.
Look for Oliver to turn to an ex-girlfriend (played by Janina Gavankar of True Blood) and current Vice cop for help with this nemesis and get your first look at him in action via the following CW trailer:


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Registration to open for Beat Diabetes Walkathon
Dubai: The registration for the fourth annual Beat Diabetes Walkathon that will take place on November 23 will be open from 15-22 this month.
The initiative, spearheaded by the Landmark Group, welcomes residents to register for free and pledge their support to the cause at Oasis Centre or any Centrepoint, Home Centre, Fitness First, Max and iCARE Clinics outlets in the UAE.
The group will also accept registrations online at www.beatdiabetes.me.
Celebrated cricketer Wasim Akram is expected to flag off the walk.


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Mortgage Servicing and Foreclosure Prevention
Two House Financial Services subcommittees held a joint hearing on mortgage servicing and foreclosure mitigation practices. Members… read more
Two House Financial Services subcommittees held a joint hearing on mortgage servicing and foreclosure mitigation practices. Members discussed the role of federal regulators in the ongoing mortgage servicing settlement negotiations and the development of new mortgage servicing standards. They also questioned witnesses about the involvement of Elizabeth Warren, the Assistant to the President and Special Treasury Adviser on the Consumer Financial Protection Bureau (CFPB), in these settlement talks. close
People in this video
- Michael D. Calhoun President Center for Responsible Lending
- Rajeev V. Date Associate Director Consumer Financial Protection Bureau->Research, Markets, and Regulation
- Mark Pearce Director Federal Deposit Insurance Corporation->Depositor and Consumer Protection
- David H. Stevens President and CEO Mortgage Bankers Association of America
- Luther Strange Attorney General [R] Alabama
- Julie L. Williams Deputy Director & Gen. Counsel Department of the Treasury->Office of the Comptroller of the Currency
- Spencer Bachus U.S. Representative [R] Alabama
- Francisco "Quico" Canseco U.S. Representative [R] Texas
- Shelley Moore Capito U.S. Representative [R] West Virginia
- Michael Capuano U.S. Representative [D] Massachusetts
- John Carney U.S. Representative [D] Delaware
- Sean P. Duffy U.S. Representative [R] Wisconsin
- Stephen "Steve" Fincher U.S. Representative [R] Tennessee
- Michael "Mike" G Fitzpatrick U.S. Representative [R] Pennsylvania
- Barney Frank U.S. Representative [D] Massachusetts
- Mike Grimm U.S. Representative [R] New York
- Nan Hayworth M.D. U.S. Representative [R] New York
- Jeb Hensarling U.S. Representative [R] Texas
- Ruben Hinojosa U.S. Representative [D] Texas
- Blaine Luetkemeyer U.S. Representative [R] Missouri
- Carolyn Maloney U.S. Representative [D] New York
- Donald "Don" A. Manzullo U.S. Representative [R] Illinois
- Patrick McHenry U.S. Representative [R] North Carolina
- Brad Miller U.S. Representative [D] North Carolina
- Randy Neugebauer U.S. Representative [R] Texas
- Edwin "Ed" G. Perlmutter U.S. Representative [D] Colorado
- Jim Renacci U.S. Representative [R] Ohio
- Ed Royce U.S. Representative [R] California
- David Scott U.S. Representative [D] Georgia
- Maxine Waters U.S. Representative [D] California
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Style Profile
Style Profile: Mary-Kate and Ashley Olsen
- Photo: Fitzroy Barrett/Retna Ltd.2 of 15
Even at a young age, the Olsens (pictured in 1993) showed that they had a point of view about style. Or maybe they inherited that quality from mom.
Get out the vote
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If you find there are broken links, misssing pages, wrong chapters or any other problems in a manga/manhwa, please comment here. We will try to solve them the first time.
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Ichi 14 released in mangahere fastest, recommend your friends to read Ichi 14 now!
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And it leads to the inescapable conclusion that people like me might be of some help in breaking the gridlock.
The gridlock over the debt ceiling is wreaking havoc—on legislators' families.
The shock will soon congeal into fear-fueled groupthink and gridlock.
The gridlock in Washington is more than just a political problem.
John Avlon on how technology and gridlock could spell an end to the curse of Ross Perot.
But thanks to the gridlock inside the official negotiating hall, the global green gathering looks less auspicious.
But nonetheless the gridlock of the past few years has produced spending restraint and higher tax rates.
They want a fresh, formidable figure who rises above the scary, petty Washington gridlock.
The empty rubbish and the trash piling up is a metaphor for when there is gridlock.
Looking at the gridlock in Congress right now, what would he think?
A blockage; paralysis: Until the emotional and psychological gridlock over the Federal deficit is broken
[1980+; fr the traffic term designating a total blockage of traffic caused by cars stopping in intersections behind other stopped cars and blocking traffic on the intersecting street]


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CCM Recreational Goalie Leg Pads
The CCM 100 Series Street Goalie Leg Pads are a great choice for the recreational roller or ball hockey goalie, offering solid protection and a lightweight design to maximize mobility.
Bauer Recreational Goalie Leg Pads
The Bauer Street Goalie Leg Pads have an awesome design and offer good protection for any goaltender playing street or recreational ball hockey.Colors: 1
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The Tour Evolution 6000 Goalie Leg Pads provide affordable lightweight protection for goalies playing recreational hockey. Tour's high quality durable materials help protect the goalie as well as help with the overall wear and tear.Colors: 1
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The Franklin 1200 Goalie Leg Pads were designed with the ball/street hockey goalie in mind. Franklin used protective high-density foam inserts in the key impact areas to offer lightweight protection.Colors: 1
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The Mylec 7000 Series Goalie Leg Pads are designed specifically for street hockey, ball hockey, or entry level recreational goalie. Heavy-duty nylon materials are used throughout these pads improving durability, perfect for the goaltenders playing on rougher surfaces.Colors: 1


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The lure is obvious: an assessment of the eastern Pacific - a 5 million sq km area known as the Clarion-Clipperton Zone - concluded that more than 27 billion tonnes of nodules could be lying on the sand.
Those rocks would contain a staggering 7 billion tonnes of manganese, 340 million tonnes of nickel, 290 million tonnes of copper and 78 million tonnes of cobalt - although it's not known how much of this is accessible.
Under the UN Convention on the Law of the Sea, the ISA was set up to encourage and manage seabed mining for the wider benefit of humanity - with a share of any profits going to developing countries.


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Coventry City: Football League docks Sky Blues 10 points
Coventry have been deducted 10 points after the Football League allowed them to start their League One campaign.
Coventry City FC Ltd went into administration in March following a row with Arena Coventry Limited over rent.
It now faces liquidation after ACL, which runs the Ricoh Arena, rejected a Company Voluntary Arrangement.
But an application by the Otium Entertainment Group for a transfer of the club's share in The Football League has been accepted.
A Football League statement read: "The League has transferred the club's share to the administrator's preferred bidder Otium Entertainment Group.
"This comes after an application under the 'exceptional circumstances' provision of the League's Insolvency Policy and on the acceptance of a 10-point deduction for the upcoming League One season despite the failure of its CVA."
"As if the situation hasn't been unsettling enough for Sky Blues fans, this impending liquidation will feel like the final straw.
"In some ways it was perhaps inevitable: both sides in the row, ACL and Sisu, always seemed reluctant to concede any ground in their pursuit of a solution and this is the result."
Dan Wheeler, BBC Coventry & Warwickshire
At a meeting on Friday, Otium Entertainment Group, who recently took over the Sky Blues from previous owners Sisu whom they have links with, and the club's main creditor, ACL, failed to come to an agreement.
Had the CVA, a payment scheme between an ailing company and its creditors, been accepted, the club may have been able to come out of administration.
However, ACL expressed its concerns over the club's agreed groundshare at Northampton's Sixfields Stadium and the club's financial future, leading it to reject the CVA alongside HM Revenue and Customs.
The day prior to the creditors' meeting, ACL lodged an official complaint against the Football League over the League One side's 34-mile move to Northampton.
It claimed that the Otium Entertainment Group had no right to request the move as its takeover of City had not been completed.
An ACL statement explained its decision to reject the CVA: "This decision was based on ACL's twin aims to first keep Coventry City playing in Coventry; and second, to ensure that Coventry City is financially viable for the next few years and beyond.
"This last point is especially important given that CCFC has been the subject of a 'catastrophic insolvency' in the hands of its previous owners.
"The CVA proposals put forward by the administrator simply do not address these obvious concerns. And these concerns are not only the concerns of ACL - they are the concerns of all Sky Blues supporters, and should be the central concerns of both The Football League and The Football Association.
"We would welcome some new proposals as soon as possible."
Under the terms of the deal between ACL and Coventry City over the Ricoh Arena, which has been the Sky Blues' home since 2005, the club had been paying £1.2m in rent per year, and only received a limited share of the catering and parking revenues from matchdays.
Eventually, the Sky Blues' debts to ACL mounted to £1.3m leading to CCFC Ltd going into administration and the club being deducted 10 points by the Football League last season.
The rent row resulted in the club agreeing a three-year groundshare with Northampton, and searching for a new permanent home in the city.
But in a bid to keep the club at the Ricoh, ACL offered a reduced rent of of £150,000 in League One, rising to £400,000 if the club returns to the Championship.
After the Football League's decision, a Coventry club statement read: "CCFC Ltd [the company that entered administration] will be put into liquidation after ACL failed to accept the Company Voluntary Arrangement (CVA) put forward by the administrator.
"Rather than the statutory 15-point penalty, the club will now receive a 10-point deduction going into the new season while the awarding of the membership of the Football League provides certainty for the future.
"Coventry City have also been cleared to play their home matches at Sixfields Stadium."
The Sky Blues start the League One season away at Crawley on Saturday.
Comment number 18. Posted by Spiceboyon 2 Aug 2013 11:28
As long as Cobblers get paid I couldn't care less. Bored of Coventry whinging about this whinging about that.
Comment number 317. Posted by zangiefon 2 Aug 2013 16:34
Comment number 352. Posted by Williamon 2 Aug 2013 17:42
Coventry, a team no one cares about. Yawn. YNWA
Comment number 225. Posted by geordie mickon 2 Aug 2013 14:10
Good riddance to bad rubbish. The Midlands is rubbish at footy like Blunderland. Let Newcastle put a B team in the league and we'll walk it. Newcatsle A team for the Champions league, B team for league one or two or wherever Covantry played and Covantry for the Birmingham league division 3 sunday morning south. Newcastle 4 ever XXX
Comment number 31. Posted by slamdunkthefunkon 2 Aug 2013 11:34
Comment number 256. Posted by garethon 2 Aug 2013 14:50
Comment number 340. Posted by just societieson 2 Aug 2013 17:03
Coventry City deserve all the misfortune of a club that thinks above its status. Coventry City and Bristol City managed to delay the kick-off for the final match of the season (top flight English football) by 15 mins,because of traffic congestiion, so they could play out a draw and niether be relegated if Sunderland lost at Everton. Keep sinking Sky Blues
Comment number 346. Posted by mcpigulatoron 2 Aug 2013 17:23
The fans should be flocking to support their club and demanding that the Council & ACL back down but Cov fans are too blinded by their irrational loathing of SISU. SISU's only crime: to cut costs and try to run the club properly.
Sadly, too many fans only accept unsustainable spending. The very sort of spending that left Cov without a ground and relegation from the Premiership with massive debts
Comment number 366. Posted by mcpigulatoron 2 Aug 2013 17:58
FL has done well. Recognises the club's proper owners but punished the club for financial problems. Shame the FL, Coventry City and SISU have been let down by ACL and the Council. And the fans. Who should be backing SISU all the way, to preserve the club's future.
In years to come, this will be the classic example of how football fans failed to support their club in the hour of need.
Comment number 277. Posted by MarkGFishon 2 Aug 2013 15:30
last time I was at the Ricoh for a game it was less than half full, Cov were woeful and I had to put up with racist chanting - towards fellow fans - so personally 'The Sky Blues' deserve all what they're getting.
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All quotes tagged Friends
(7488 quotes found)
"He that is thy friend indeed,
He will help thee in thy need:
If thou sorrow, he will weep;
If thou wake, he cannot sleep:
Thus of every grief in heart
He with thee does bear a part.
These are certain signs to know
Faithful friend from flattering foe."
"To me, fair friend, you never can be old. For as you were when first your eye I eyed, such seems your beauty still."
"Do you know why you forgot the activities you've been through? would you be embarrassed if there are activities that you yourself not come, then your friends are talking about in a memories album ? because you don'tt play an important role for that activity, do important role from now !"
"Which will you choose: the easy or difficult path? You must trust, have faith and follow your heart in your direction; then and only then, will you discover the great treasures of life."