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Submited by- Sitagita Team on 27 May, 2013 ENTERTAINMENT BOOKS & MUSIC
You know what makes Bollywood so special? It's music! Yes, Bollywood music is peppy, groovy and available in a wide range of genres to fit any occasion. A Bollywood movie, however big a hit it is, has a shelf life but the music is immortal. Be it the soulful music of movies such as Arth, Masoom etc or the hip and foot tapping numbers from Dabangg or Race 2, Bollywood music has taken dif... Read More...
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Submited by- Sitagita Team on 06 Jun, 2013 ENTERTAINMENT BOOKS & MUSIC
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Submited by- Sitagita Team on 11 May, 2011 BEAUTY & FASHION SKIN CARE & BEAUTY TIPS
you vow to realise your inner beauty and take pride in looking good. This is the day when you... celebrate your womanhood and open up to the potential of your beauty and sensuality. Feel Good We... that looking good is about feeling good. So on this day, break away from the typified image of beauty... meditation. Ponder on your best points and try to soak in the positive energy that is around you.... Promise to yourself that you will through positive thinking bring out your best. Enhance this effect Read More...
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Submited by- Sitagita Team on 20 Oct, 2011 RELATIONSHIPS DATING & RELATIONSHIPS
Poems have a lot of importance in day to day living and have been found one of the best ways... to express human feelings to others in the society. Hindi has been our mother tongue and although we may... that binds all of us together with one common thread. This common language is called Hindi and represents... the class of our most learned and intelligent writers, scholars and authors. Hindi poems have been... of feeling, poems are one of the best ways in putting any such feeling across to the audience. No wonder Read More...
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Submited by- Sitagita Team on 20 Oct, 2011 LIFESTYLE HOME & OFFICE INTERIORS
guessed it right; it's our very popular Hindi language. Hindi forms base of our common medium... Bollywood is by the songs that the movies have in Hindi. Hindi songs leave an impact on us, be they from... such as "Tere naina". Whatever the case may be, the songs in hindi have something to please the souls... and the singing freak in all Indians. The songs in hindi are so lively and are composed with such great lyrics... of melodious songs in hindi that can be sung for as long as one wants. To be true, the inventory of songs Read More...
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Submited by- Sitagita Team on 20 Oct, 2011 RELATIONSHIPS DATING & RELATIONSHIPS
The movies in Hindi constitute one of the biggest constitution in the world—the hindi film... together in making all kinds of movies in Hindi. These movies form a big means of entertainment... for the people in India and also many other parts of the world. The movies in Hindi, especially the ones.... This is because movies in hindi that are made today draw their inspiration from every part of the world, not only... that the movies in Hindi attract today. Because some movies also try to incorporate some elements from Read More...
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are thinking about a wedding gift, the wedding invitation is the best thing to guess the theme and plan a gift... to your spouse, it is one of the best gifts that she will definitely like. Scrapbook is also one... or any other picture of their best moments that they spent together and are special for them. It can... which can make day more joyful. Surprise party is also one of the best memorable gifts that one can... are Searching for best Wedding Gift And Anniversary Invitations in your budget then please Read More...
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'Shuddh Desi Romance'- Will it be a hit?
|48% | 61 votes
|May Be
|23% | 29 votes
|28% | 35 votes
|Total Votes: 125
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Jenny, Lila, and Thalia…bound and gagged!Posted on April 20th, 2015
Captured Snapshots posted their latest updates for the week of April 20th, 2015…
Our exclusive model, gorgeous blonde Jenny tied up tightly and cleave gagged in high heels, pantyhose, a camo minikisrt, and a blue top! Jenny is the #1 most popular model on this website!
Our exclusive model, sexy blonde Lila, tied up tightly and ball gagged in high heels, tight blue jeans, and a plaid top!
Pretty blonde Thalia, bound and cleave gagged in black high heels, pantyhose, a miniskirt, and a tight cotton top!
Visit Captured Snapshots today and see all of our latest updates for this week…
Andrea, Jessie, and Hannah Perez…bound and gagged!Posted on April 6th, 2015
Captured Snapshots posted their latest updates for the week of April 6th, 2015…
Petite blonde Andrea, tied up cross-legged, ball gagged, and exposed, in argyle socks, blue jeans, and a ted top pulled up to expose her perky tits!
Busty, long-haired beauty Jessie, bound, gagged, and exposed, in pantyhose, red high heels, a miniskirt, and a red tank top pulled up to show off her big boobs!
Busty doll Hannah Perez tied up tightly and gagged with duct tape in pantyhose, high heels, a miniskirt, and a tight top! This gallery is part one of two.
Visit Captured Snapshots today and see all of our latest updates for this week…
Charlotte, Cali Logan, and Hannah Perez…bound and gagged!Posted on September 8th, 2014
Captured Snapshots posted their latest updates for the week of September 8, 2014…
Our exclusive model, busty babe Charlotte, bound and gagged with duct tape, with her big tits exposed, in a tight top, a miniskirt, panties, and pantyhose! Charlotte is one of the most popular models on this website!
Gorgeous brunette Cali Logan, tied up tightly, cleave gagged, and exposed in a tight miniskirt, pantyhose, high heels, and a sweater pulled up to show off her nice tits!
Busty doll Hannah Perez, cleave gagged and bound up with rope in a tight pink top, a plaid miniskirt, pantyhose, and high heels!
Visit Captured Snapshots today and see all of our latest updates for this week…
Bondage-Loving Sorority Girl – Part 2Posted on August 21st, 2014
Nastasia is not done with the torment. She expertly applies more rope to Charlotte which attaches her upper body to the beam. With her wrists tied in front and then down to her knees she can't bring her hands up. The way she's tied she can't lean over so there is no way for her to reach her gag. Nastasia asks her questions. Lots of them. Charlotte answers with muffled sounds because there's a 2 inch ball strapped in her mouth. Nastasia pulls her top down so you can see Charlotte's lacy bra. Then she pulls the bra down so you can see those magnificent tits. As a final insult she takes Charlottes stinky heels off. She then holds one in front of Charlottes nose and you can see her squirm and try to get away. Not satisfied yet, Nastasia tapes the shoe to her face so it's stuck there and then she tapes around her head and also around the beam. Charlotte is now forced to hold her head back while ballgagged and with her shoe stuck to her face!
See more latest updates over at Escape Videos!
Bondage-Loving Sorority Girl – Part 1Posted on August 18th, 2014
Nastasia and Charlotte are two sorority sisters that are throwing a party for the girls. They can't decide on a theme. Nastasia has an idea. That idea involves tying up some of the sorority girls and having them for decoration. What a pervert Nastasia is. She just happens to have a bunch of rope nearby and talks Charlotte into practicing on her. She uses a fair amount of rope and soon has Charlotte bound to a beam with her hands in front of her. Charlotte thinks that it's the end of "practice" but no. Nastasia fools her once again by asking her to make a certain sound. The sound requires Charlotte to open her mouth and that's when Nastasia shoves a 2 inch ballgag in! Immediately Charlotte is annoyed and starts trying to talk. Nothing you can understand comes out of her mouth. Now she's angry but it's too late. Watch for part two to see what Nastasia has in store for her. All tying and gagging is done onscreen. Two beautiful well built girls that you won't see on another site!
See more latest updates over at Escape Videos!
Carlotta, Nastasia, and Kendall Renee…bound and gagged!Posted on July 21st, 2014
Captured Snapshots posted their latest updates for the week of July 21st, 2014…
Meet our newest model: pretty brunette Carlotta, bound, exposed, and gagged with tape in high heels, a purple miniskirt, pantyhose, and her tight top pulled up to show off her beautiful tits!
Our exclusive model, busty babe Nastasia, bound with lots of rope, and gagged with her big tits exposed, in pants, and open shirt, pantyhose, and high heels! Nastasia is one of the most popular models on this website!
Our exclusive model, petite beauty Kendall Renee, bound and ball gagged in a miniskirt, a silk top, pantyhose, and high heels! This gallery is part two of two.
Visit Captured Snapshots today and see all of our latest updates for this week…
Hogtied and Hooded DroolerPosted on July 5th, 2014
This clip starts with Jennifer bound in jeans, pantyhose, heels and a top that's unbuttoned to show off those perfect perky tits. She's struggles mightily and tries talking through her gag which is not very effective. Stacy approaches her and sits her on the ground. She removes Jennifer's heels to show off her pantyhose clad feet. Next, it's time to remove that ineffective gag so Jennifer can really be stopped talking! Stacy shoves a 2.5 inch ballgag in her mouth which shuts her up. She takes a length of rope and pulls Jennifer's bound wrists to her ankles effectively hogtying her. Jennifer is stuck and there's not much she can do. She isn't done trying to talk and the drool begins to flow. Stacy then takes a pair of sheer pantyhose and hoods her tightly enough where Jennifer's pretty face is now contorted. Stacy ties the legs of the pantyhose around Jennifer's ankles and this makes the hogtie even worse. The already aggravated, frustrated and humiliated drooling Jennifer continues drooling right through her hood. Lots of close-ups of the drool flow! Like tight hogties, large ballgags, pantyhose hoods and lots of drooling? Feast your eyes on this one! Jennifer has an all natural beautiful body, a pretty face and feet that you'd to love rub!


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2 bed flat for sale
£300,000 Guide Price*
Guide Price* £300,000
Shop for sale 154 Clare Road, South GlamorganGround Floor let to Greggs on a lease expiring 2021 with two flats above let on AST's. Total rents reserved £29,200pa. More details ›
Added on 14/11/2015 by Allsop , Commercial Auctions. Call: 020 8012 9204 Local call rate
5 bedroom flat for sale Blaenclydach Street, GrangetownTOTAL WOULD BE £345,000 TO PURCHASE INDIVIDUALLY......TAKE THE WHOLE PROPERTY FOR £279,950. Landlord advises an income of £2,000 per calender month. More details ›
4 bedroom semi-detached house for sale Penarth Road, Grangetown, CardiffThe accommodation briefly comprises entrance hallway, living room and an open plan kitchen/dining room to the ground floor. To the first floor are three bedrooms and an upgraded bathroom. There is a further bedroom and shower room in the loft space. More details ›
£250,000 Guide Price
Guide Price £250,000
1 bedroom flat for sale Clarence Road, Cardiff, South GlamorganThe Express Estate Agency is proud to offer this REALISTICALLY PRICED opportunity – all interest and OFFERS are INVITED. First Floor Flat Open Plan Living Space Kitchen Utility Area 1 Bedroom Bathroom Double Glazed & Centrally Heated (Wher... More details ›
3 bedroom terraced house for sale Clive Street, Grangetown, CardiffAn opportunity to acquire an investment property in the Grangetown area of Cardiff close to Cardiff Bay. The property currently consists of two maisonette flats. The ground floor maisonette has three bedrooms and the first floor maisonette has two bedrooms. More details ›
4 bedroom semi-detached house for sale Bessborough Drive, Carlton Gardens, CardiffAllen & Harris are pleased to offer for sale this beautiful four double bedroom property situated in Grangetown. This home is perfect for raising a family with benefits of two reception rooms, enclosed rear garden and is within walking distance to local amenities. A viewing is highly recommended. More details ›
£230,000 Offers in Region of
Offers in Region of £230,000
4 bedroom terraced house for sale Dinas Street Grangetown Cardiff CF11 6QZNO CHAIN - DOUBLE BAY FRONTED TRADITIONAL TERRACED 4 BEDROOM FAMILY HOME - 3 RECEPTION ROOMS - Mr Homes are pleased to Offer FOR SALE this 4-Bedroom Family Home. The Property comprises of; Entrance Hallway, Front Reception Room, Middle Reception Room, Rear Lean To Room, Middle Reception Room, R... More details ›
£230,000 Guide Price
Guide Price £230,000
5 bedroom terraced house for sale Penarth Road Grangetown Cardiff CF11 6FRGuide Price: £230,000 to £235,000 - LARGE 5 BED FAMILY HOME - 3 RECEPTION ROOMS - DOWNSTAIRS WET ROOM - LARGE KITCHEN/DINER - Mr Homes Offer FOR SALE this 5-Bedroom Terraced Family Home. The Property Comprises of; Entrance Hall, Front Reception, Middle Reception, Downstairs Wet/Show... More details ›
4 bedroom terraced house for sale Pentrebane Street, Grangetown, Cardiff, CF11 7LN.*** OPEN HOUSE SAT 5TH DECEMBER - 12PM-2PM BY APPT ONLY*** This traditional, double bay fronted four bedroom terraced house is situated in the popular Grangetown area of Cardiff. It has excellent transport links and is conveniently located within approximately half of a mile of both Mermaid Quay ... More details ›
4 bedroom terraced house for sale Clive Street, Grangetown, CardiffA newly refurbished bay fronted house located on the ever desirable Clive Street, Grangetown. This much improved home offers substantial accommodation including three receptions, four bedrooms, two bathrooms and fitted kitchen. GCH, DG, forecourt and rear garden offering parking. Must be viewed! More details ›
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Your information has been sent to 0 out of 26 agents who have property to sell in the area you specified.
*Guide Price: An indication of a seller's minimum expectation at auction and given as a Guide Price or a range of Guide Prices. This is not necessarily the figure a property will sell for and is subject to change prior to the auction.
Reserve Price: Each auction property will be subject to a Reserve Price below which the property cannot be sold at auction. Normally the Reserve Price will be set within the range of Guide Prices or no more than 10% above a single Guide Price.


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- Real-time account access & review
- ACH Origination, i.e. payroll
- Transaction management and history
- Transfers among accounts including multiple entities
- Employee access and security management
- RDC (Remote Deposit Capture)
- Electronic Bill Payment
- Payroll Direct Deposit (to checking/savings, HSA)
Online Banking
Intercity Online for Business (IOL-B) is Intercity State Bank's business internet solution. IOL-B provides high performance, 24/7 online banking with features that enhance corporate cash management, e-commerce, and core banking activities. Features include:


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Aug 24
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Jan 14
NEW NEWS! Latch Key Kids EP release! 14 Jan 2012! Fitzgerald's Houston! w/ The Buzzkillers, Dead To The World, The Hates, and Llorona! - $8 in advance or $10 at the door, so get them early! See you there!
Jan 13
Bio: LKK has been playing off and on since the summer of 93'. We're about to start playing out again with lots of new tunes. In the last few years we've shared the stage with Bad Religion, NOFX, Strung Out, NUFAN etc..... Thanks to all these guys!!!!! We look forward to seeing everyone again soon. Che...See Full Bio


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Nationals pitcher Gio Gonzalez is a big basketball fan and decided to go see the Wizards battle the Lakers at the Verizon Center on Tuesday night. He had some pretty nice seats, sitting baseline under the basket on the Wizards' side. He tweeted earlier in the night he was there to support his friend John Wall.
Wall dropped 31 points, the Wizards won, and it sounds like Gio had a good time. Today he sent out a photo saying it was one of the "greatest moments" of his life:
You can also see Gio celebrate Wall's 360 dunk in this video as well.
There's Gio in the white shirt:


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Light Yagami
36,656pages on
this wiki
this wiki
| "Light Yagami" may be referring to two or more different villains. If you're uncertain which one you're looking for, just flip a coin.
If you came here from a link, please go back and make the right link for one of the villains listed below.
Light Yagami is the main protagonist of the Death Note series. Light is characterized as hardworking, talented, and a natural genius. Light would constantly predict all of the possible scenarios that could happen, and plan a solution in advance, even in the most impromptu situations. His only faults are his deep sociopathic interior, his cynical outlook on life, his overconfidence in himself and in his belief that he is never wrong.


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UPDATE August 2015:
As of July 2014 we no longer sell raw milk as C2 Farms Dairy decided to close their business. We are in the process of starting our own raw milk dairy but it will take some time. We hoped to be up and running by now but the process has taken longer than expected. We're pursuing two different options to start our own grass-fed, raw milk dairy and will keep updating as things progress. Thank you for your patience as we figure it out!
If you would like to receive updates from us and be notified when milk is available, please sign up for our e-mail list on the homepage of our website. Thank you.
Please note: Raw butter, cream, sour cream, etc. are illegal in the state of Utah and we will not carry those in our store. We do carry a selection of raw milk cheeses which you can find more about on the Farm Store page.


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If you find there are broken links, misssing pages, wrong chapters or any other problems in a manga/manhwa, please comment here. We will try to solve them the first time.
Please enter the email.
Sadomi 5 released in mangahere fastest, recommend your friends to read Sadomi 5 now!
Tags: read Sadomi 5 english, Sadomi 5 raw manga, Sadomi 5 online, Sadomi 5 chap, Sadomi 5 chapter, Sadomi 5 high quality, Sadomi 5 manga scan
Sadomi 6 is coming next...
Previous Chapter: Sadomi 4


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Expert Service 1-877-289-7664 [Hours]
Kinetik KIPS12-45
45 Amp 12 Volt Power Supply and Charger with Smart Dual Mode Design
Get FAST answers from customers ASK a Question See questions answers
Kinetik Intelligent 120 VAC to 12 VDC Power Converters are state-of-the-art electronic converters / battery chargers. Their compact size and quiet operation gives greater flexibility in selecting the mounting locaiton for either OEM installation or after market replacement.
The Kinetik Intelligent Power Converters have a computer controlled charging module built in. This is a microprocessor-controlled device which constantly monitors the battery, and then automatically adjusts the converter output voltage based on its charge status. There are four (4) operating Modes (Normal, Boost, Storage and Desulfation/Equalize). Each mode is automatically selected by the microprocessor and ensures a fast yet safe recharge for the connected battery.
- 12 Volt KIPS Series Power Supply
- Electronic converter/battery charger
- Built-in microprocessor constantly monitors battery voltage and automatically adjusts output
- Capable of charging multiple batteries at the same time
- Smart Dual Mode design
- Automatically kicks up voltage for high demands
- Reduces to float mode when at idle to conserve power
- Thermal protection mode decreases power until unit returns to normal operation temperature
- Ignition protection
- Variable speed cooling fan runs only at speed needed to prevent from overheating
- Overvoltage protection
- Designed for noise free power
- GFCI Protection safely operates without ground fault interruption
- Reverse battery protection circuit with ATC type fuses
- Short circuit protection senses within millionths of a second if output terminals have been shorted
- Designed specifically to charge and maintain Kinetik Power Cells and most 12-volt batteries
- Also works perfectly for soundboards, competition, and show vehicles without introducing any noise into electrical systems or sensitive audio electronics
- Also available in 60 Amp and 80 Amp
- Dimensions: 8-5/8"L x 7-1/4"W x 4-1/2"H
- Authorized Internet Dealer
- 1-year Manufacturer's warranty
- Input: 105-130 VAC 60 Hz 725 Watts
- Output 13.6 VDC, 45 Amps
- Volts: 12
- Amps: 45
General Features
AC to DC: Converts common household AC power to DC Power.
DC to AC: Converts DC power to the common household AC power. Often times these converters can be plugged into the vehicles cigarette lighter.
Specials with this Item
Warranty and Return Policy
Summary of Customer Ratings & Reviews
Please get with a Kinetik Tech for details on how to match the amperage with your specific project/application.
Toll Free: 1-888-522-8346 | 9AM ~ 5PM CST
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Wiring Diagram Legend
Warning: The image depicted shows the resistance change when wiring multiple subwoofer terminals. Please refer to your subwoofer's owner's manual for the proper wiring of its terminals. Sonic Electronix, Inc. is not responsible for damage caused to your audio system or vehicle due to improper installation. Please call tech support at 1-877-289-7664 if you require additional assistance.
Product Name: Kinetik KIPS12-45
The Sonic Advantage
What gives Sonic the edge over the competition
Fast & Free Shipping
We offer free shipping on thousands of popular items for our Continental US customers and discounted rates for international customers. With multiple warehouses across the US, most orders are delivered within 3 days!Learn More
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We pride ourselves on offering the best products at the lowest prices. If you find an identical item on another website with a lower price, we will discount our price by 105% of the difference. Some restrictions apply.Learn More
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Have a problem with your order and need to return an item? Our generous 60-day return policy allows you to return items for your money back. Should your product have a defect, we will exchange, issue store credit, or repair the product for the entire length of the warranty.Learn More
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Our knowledgeable staff of industry professionals and certified installers is ready to help you pick the right product for your needs. We will help you with the setup, installation, and use of your new products.Learn More
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We want your online shopping experience to be easy and convenient. In case you need to return an item, our customer friendly return policy makes it easy.
60-Day Money-Back Guarantee
Have a problem with your order and need to return an item? Our generous 60-day return policy allows you to return items for your money back. Should your product have a defect, we will exchange, issue store credit, or repair the product for the entire length of the warranty. Learn More
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That's right, 100% refund on complete, like new returns. Learn More
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Let's face it, electronics break. We've got you covered for a full year. Learn More
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Request a return, use our shipping label, and ship it back. Learn More
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Each of our employees are true experts with real life experience and passion for the products. Our team is always committed to providing you with electronics you'll enjoy.
Always available to answer your questions
Our trained install professionals can tackle any install challenge
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Browse our online library of educational resources to learn more about the items you are looking for. Our experts have developed many tools, written many articles, and numerous videos to help you find the best item for your needs.


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Wake-on-ring with "fake" UPS on serial port
If you are very technical and can design your own magic packet emulator the wake-on-lan is a neat idea.
Ok, just relised that my motherboard does not have that thing where you push the power button and it turns off, so i had the idea of making somthing that attaches to the serial port or parrallel port and then putting that to the shutdown controller instead of the 2 mother board pins, would anyone know how to go about doing this??
Wake-on-ring with "fake" UPS on serial port
If you are very technical and can design your own magic packet emulator the wake-on-lan is a neat idea.
A one point I was playing with this hardware / software combo,
and if I remember correctly it has a shut down function, there is (was?) also a plugin for Winamp which causes it to auto shut down the PC when you exit.
And you say people actually pay money for M$ Windows?
www.mp3mini.co.uk (Does what it says on the URL) www.openclassic.co.uk (The new car, with zero rust!) www.rob-web.co.uk (My other site)
Total re-design underway: on the whole progress is very slow as the car is taking up too much time :)
Yes, well now I have my LCD and all I need to buy is the wire I think I am just going to use another motherboard thats the easy way out :-D
i use girder for this, i got ignition connected to a relay so when ignition is OFF the relay is closed and hence a button is "pushed" on the serial port, you need the serial plugin for girder, wiring diagram is included. i have it set so if my ignition is off for more than about 4 seconds the computer shuts itself down (gives me time to crank the engine)Originally Posted by owenjh
Do you still have to manually turn on the computer, or is it also possible to "wake" the computer via switches wired to the serial port?Originally Posted by Nic
i dont think its possible without using wake on ring for modems, which means sending modem commands not using switches, i attatched my power button to my central locking, so the pc starts booting when i unlock my doors, so long as i get in and turn my key in the ignition the computer stays on, otherwise it powers itself offOriginally Posted by sigma957


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Babbel As you work through a program in Babbel, you'll frequently see this page, which shows your progress (green bar graph at the bottom) and the next activity you should complete if you want to work in order through your chosen course. The next slide shows the bottom half of this same screen, where your courses appear.
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Artnoise Jazz Radio. Listen live 24 hours 7 days
The artnoise radio is one of jazz music on internet radio station. With great care and diligence selects unique tracks new or old that have made history.
The jazz music characterized for style and quality. The sound quality is excellent and fully meets the requirements of each listener.
Live music is offered us three flow patterns: MP3, Windows Media Audio and AAC-HE forms.
Jazz is the only music in which the same note can be played night
after night but differently each time.
- Ornette Coleman
October 2015
European Jazz Expo Date: October, 2015 Location: Cagliari, Italy DølaJazz Lillehammer Jazz Festival Dates: October 15–18, 2015 Location: Lillehammer, Norway
September 2015
Louis Armstrong Celebration Festival Dates: September 11–14, 2015 Location: Bracklesham Bay (nr Chichester), United Kingdom The World Jam Dates: September 24–27, 2015 Location: Madrid, Spain Jazz Fest Žilina Dates: September…
August 2015
Nõmme Jazz Festival Date: August, 2015 Location: Tallinn, Estonia Festival de Big Band de Pertuis Dates: August 3–8, 2015 Location: Pertuis (nr Aix-en-Provence), France Sildajazz Haugesund International Jazz Festival Dates:…
July 2015
Bluetone Das Festival an der Donau Date: July, 2015 Location: Straubing, Germany Ça Jazz à Huy Date: July, 2015 Location: Huy, Belgium Kongsberg Jazz Festival Dates: July 1–4, 2015 Location:…
June 2015
Jazz en Nord Festival Dates: September 13, 2014 – June 30, 2015 Location: Bondues, Croix, Dunkerque, Lille, Lomme, Marcq-en-Barœul, Mouscron, Mouvaux, Roubaix and Villeneuve d'Ascq, France Nattjazz Dates: May 28…


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Fri., October 28, 2011 2:35am
Coach Beating Triggers Added Security
A community in east Georgia is still trying to come to terms with a brutal beating of a coach that took place two weeks ago after a high school football game. A melee broke-out between the players of Warren County and Hancock Central. The incident has prompted reviews of post-game conduct by other school districts.
Full Story
©Copyright 2015, Georgia Public Broadcasting. All Rights Reserved
Georgia Public Radio®


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As the George W. Bush Presidential Library and Museum opens today, some in the press have been caught up in a swoon over the former president.
Pundits from the center and the avowed left called on critics to re-examine the former president as a "good man with a good heart," while those on the right declare that "Bush is Back." Political analysts are compiling lists of "The 7 best moments of George W. Bush's presidency" and highlighting polls indicating that Bush is more popular now than he was in office. And Fox News has pulled out all the stops, lining up their Bush-administration-officials-turned-Fox-employees to sing the former president's praises.
Presidential historians and veteran reporters who covered the Bush White House are speaking out, saying that reporting on the Bush library and legacy should put his failures in their proper context.
The academics point out that while some of Bush's defenders in the press have said that the Bush legacy is a question for history, historians largely pan his tenure. And the veteran reporters who covered Bush's presidency urge that coverage of the presidential library provide a complete accounting of his tenure in office, including its many missteps.
"The press needs to take a really cold-eyed look at the circumstances ... look at the state of the country and world on Jan. 20, 2001 and eight years later," said Ed Chen, former Los Angeles Times and Bloomberg correspondent who covered the White House from 1999 to 2010. "Were mistakes made? Sure, the whole WMD fiasco ... it sure has a long way to go for anything close to a full rehabilitation."
Chen later added, "Of the three [presidents] that I covered, we have to put Bush at the bottom."
Several top presidential historians echoed Chen's low-ranking view, noting a week of positive coverage cannot erase that.
"Right now he's ranked as one of the lower presidents because of the War in Iraq and the economy tanking so he's got a long way to go to get rehabilitated," said Douglas Brinkley, a top presidential historian and author. "It is a long revisionist road up from the bottom for George W. Bush. He is ranked toward the bottom rung of presidents."
Indeed, surveys of historians regularly find Bush ranked among the worst of U.S. presidents.
Having toured the new library at Southern Methodist University in Dallas, Brinkley described it as having a "compassionate conservative motif" for Bush, adding, "I was surprised how much wall space was given to AIDS in Africa, marine conservation, No Child Left Behind. I got the feeling that the Bush crowd was trying to paint their president as more of a centrist than many people feel."
But Brinkley stressed that whatever positive image is being attempted this week cannot rewrite his presidency.
"I don't think it matters two weeks from now, it is a building opening and people tend to be jubilant," he said. "It's the beginning of revisionism of a presidency."
New reports that the politically conservative Koch brothers are interested in buying the Tribune Company's eight regional newspapers -- which include the Los Angeles Times and Chicago Tribune -- are sparking concerns from newspaper staff members that attempts to influence the editorial process in favor of their far-right political views may follow.
Among those concerned is Clarence Page, a top Chicago Tribune columnist, who said he would oppose a takeover of the paper by David and Charles Koch because of "the fact that they seem to be coming in upfront with the idea of using a major news media as a vehicle for their political voice."
Since Sunday, both The New York Times and The Wall Street Journal have reported that the Kochs are among leading contenders to purchase the newspapers from the financially troubled Tribune Company.
In addition to the Los Angeles Times and Chicago Tribune, the Kochs are reportedly seeking to buy The Baltimore Sun, the Orlando Sentinel, the South Florida Sun Sentinel, The Hartford Courant (Hartford, CT), The Morning Call (Allentown, PA), and the Daily Press (Hampton Roads, VA).
The Kochs are major funders of the American conservative movement, funneling tens of millions of dollars every year to build a right-wing infrastructure geared toward reducing the size and impact of government. As the Times detailed, at a 2010 convention of like-minded political donors, the Kochs "laid out a three-pronged, 10-year strategy to shift the country toward a smaller government with less regulation and taxes." Part of the stratgy called for investing in the media.
And that has staffers at Tribune Company newspapers -- several of whom requested anonymity for fear of losing their jobs -- nervous about the possibility that a Koch takeover could bring with it an ideological focus on the news that risks turning the papers into what one reporter calls a "conservative mouthpiece."
According to those staffers, such concerns are rampant at the papers. "Nobody I know in the newsroom would find it a happy event to have the Koch brothers owning the paper," said one longtime Chicago Tribune staffer, who suggested that the purpose of the takeover is so that the brothers can use the publications to "promulgate their political views."
"I haven't heard anyone here who has welcomed the idea of the Koch brothers... the Koch brothers, that scares people," added an LA Times scribe.
"I think we all have concerns when you think an owner might try to influence editorial content," explained Angela Kuhl, Newspaper Guild unit chair at The Baltimore Sun. "That is sort of contrary to what the newspapering business should be about, free press. You don't necessarily want owners and publishers dictating content."
It's the Kochs' explicit call for investing in the media to achieve their political end that has Kuhl worried. "I read the story that said they have a three-pronged approach to how to move the country in the way they think it should head, and one is to influence the media."
The New York Post has seen three of its supposed scoops about the Boston Marathon bombing fall apart this week. Nonetheless, their editor is unrepentant, lashing out at critics and claiming a "crystal ball" would have been necessary for the paper to publish accurate information.
In a widely criticized move, the April 18 Post front page featured the headline "Bag Men: Feds seek this duo pictured at Boston Marathon" along with a photo of two men holding bags at the event. The article reported that investigators had been "circulating photos of two men spotted chatting near the packed finish line" and also that officials "have identified two potential suspects who were captured on surveillance videos." The Post added that "it was not immediately clear if the men in the law-enforcement photos are the same men in the surveillance videos."
The paper later reported in an online story that the two men they had featured on their front page had been "cleared."
In an email to Media Matters, Post editor Col Allan claimed that when the photo was published this morning, the article stated that the FBI was only emailing the photo to other law enforcement officials and noted "there is no direct evidence linking them to the crime."
"With regard to today's front page emails containing images of the two young men were sent to law enforcement offices, federal and state, at 3pm yesterday seeking information about them," Allan said in an e-mail. "I have a copy of one of those emails sent to a regional office of the FBI. At no point did the Post state they were 'suspects.' Today it is clear they were not involved ... had you loaned us your powerful crystal ball we would have known this before the presses ran."
But, asked specifically if placing the photos on Page One was misleading because it gave the appearance the men were somehow involved, Allan stated via email:
"Common sense would suggest if the FBI emailed pictures of these men standing around the Boston marathon to law enforcement offices asking for information about them it might be newsworthy. We made no judgment about the men. We simply reported the facts. Their photos were emailed by the feds. Information about them was sought. If it is your idea that we or anyone else in the media wait until the complete truth is clear then there is little need for journalists. Only historians. "
Allan also claimed that a previous incorrect Post report on Monday, that 12 people had died in the bombing -- which has yet to be corrected - was also not the paper's fault.
"Our sources were federal authorities who have been reliable in the past," he wrote. "In this event, they and thus we, were wrong. Later Monday our reporting online and in Tuesday's paper accurately reflected the official toll...give your crystal ball a good hard polish and drop it over sometime."
The day of the bombing, the Post also reported that a Saudi national student had been "taken into custody" and was considered a "suspect." That student was also cleared of involvement. In response to questions about that story also falling apart, Allan claimed that "The Post said a Saudi student WAS detained in hospital after the bomb blast. He was not free to go. at 2 am the following morning the federal bureau of investigation raided his flat and took away several bags of material. The next day the authorities stated he was co--operating and not considered a suspect. The post would have required one of your hindsight crystal balls to have known this."
The Orange County Register's newest weekly sections on local colleges, which are being financed in part by the colleges themselves, are raising concerns about conflicts of interest and credibility from both inside and outside of the newspaper.
At issue is the financial arrangement the Santa Ana, CA, daily has with three local campuses: Chapman University; California State University, Fullerton; and the University of California at Irvine.
Under an agreement reached earlier this year, the paper is publishing a separate, weekly six-page special section devoted to positive coverage of each university's news and events. Each of those sections include two columns authored by top university staffers.
In exchange, each university is paying the newspaper $275,000, supposedly for advertising that will appear in that section for one year. The sections began running on April 1.
The financial arrangement and partial control of content by the universities has some at the paper and on campus concerned.
"It does make me a little uncomfortable," said Bill Johnson, a Register columnist. "In this business, appearance is everything. Appearance-wise, it is a bit troubling. If you know people are paying for coverage does that affect the coverage? I would like to think we are way above that, writing good news to satisfy an advertiser."
Jeffrey Brody, a journalism professor at Cal State, Fullerton, and a former Register reporter, called it a "disguised advertorial."
"That's a breach of the wall between editorial and advertising of traditional newspapering," he said. "A newspaper should not be making these kinds of quid pro quo agreements. It seems that that does damage the credibility of the university."
A review of the most recent sections from April 15, 16, and 17, finds stories written by Register staffers, along with two pieces from each university's faculty or administration.
A half-page color ad for the university appears on the back page of each section.
The stories range from a review of the number of bronze busts on the Chapman campus to a report on UC-Irvine's annual "Undie Run." None of the stories could be described as critical of the school.
While newspapers often clearly label such content as "advertisement" or "advertorial," the only note related to the Register's arrangement is a small box on the inside of the page alongside the staff list stating "while the university is the section's primary advertising sponsor, all editorial decisions are independent of the university's control."
Pulitzer Prize-winning historian Robert Caro criticized conservative media coverage of President Obama during an appearance in New York City, describing it as "something quite horrible" and venomous.
Caro, known for his biographies of President Lyndon Johnson, spoke during a March 29 interview at Strand Books in Manhattan conducted by New York magazine writer Frank Rich as part of promotion for the paperback version of his fourth Johnson book, The Passage of Power.
Caro, who won Pulitzer Prizes for his third Johnson book, Master of the Senate, and his 1975 book about Robert Moses, has long used newspaper and media coverage in his research about U.S. political history.
Asked by Media Matters what he thought of today's conservative media coverage given his experience with historic news accounts, Caro said there had been strong conservative news coverage of past political figures, but stressed today's approach is worse.
"I think today is something [different], the venom, the absolute venom, whatever we think is really underneath it all, it is something quite horrible," he said, later adding, "Here in New York you live in a different world. I was just giving some lectures and you know when you get out in the rest of the country you realize the depth of the anti-Obama feeling."
Caro's comments follow years of conservative media figures smearing President Obama and his family with outlandish conspiracies, regular falsehoods, trumped-up pseudoscandals, and outright attacks.
Dick Morris is working with Republican National Committee Chair Reince Priebus on a new television advertisement that will include Preibus seeking to attract Latino voters, Morris revealed during an appearance in New York City Thursday.
Speaking at the Poli Conference, a political consulting event for Latin American campaign professionals, Morris said the ad will feature Priebus reaching out to "those Latin Americans who've come to the United States to help us build our country, to help harvest our food, to help make our economy work and [Priebus'] message is 'welcome, we need you, you're making our country younger, more prosperous, harder working and we need you for the future.'"
According to Morris, the ad will make use of "that concept of reflecting back to people their own value and their own worth. In the advertisement he [Priebus] says, 'we honor our ancestors who took covered wagons to settle the west and brave the Indians, but you are the new pioneers, you are the new people in America doing that.' And I think that is a very, very interesting thing to do in a campaign."
Republican Party Spokesman Ryan Mahoney did not immediately respond to a request for comment on the ad. Asked about when it might run or where, Morris declined to offer more details.
Morris' work with the Republican National Committee is noteworthy given the implosion of Morris' stature and credibility following the 2012 election and his now infamous prediction of a "landslide" victory for Republican Mitt Romney. After the election Morris was effectively banned from appearing on Fox News, where he worked as an on-air contributor until the network declined to renew his contract in early February. Morris also brings with him a host of ethics problems -- Morris' group Super PAC for America reportedly spent significant amounts of money renting Morris' own email list in the months before the election, allowing him to simply pocket money raised by the group.
Veteran media and criminal defense attorneys agree that the Daily Caller could be subject to a possible libel or defamation lawsuit or even criminal charges if it is proven the publication paid women to lie about having sex with Sen. Robert Menendez for money.
The Daily Caller first reported in a November 1 story allegations from two anonymous women who claimed they were Dominican prostitutes who had been paid by Menendez for sex. Over the past month, the story has slowly fallen apart.
Dominican law enforcement officials have said they determined that the three women who had made allegations about Menendez had actually been paid to do so by Miguel Figueroa, a Dominican attorney who was the only named source in the original Caller report. One of the women has reportedly signed an affidavit retracting her claims and said she was paid to lie.
Last week, the head of the Dominican National Police said Figueroa had blamed the Caller for the entire debacle, claiming that someone allegedly from the publication had supposedly paid him to find prostitutes who would lie about having sex with Menendez.
The Daily Caller has strongly denied making any payments.
Nonetheless, one criminal defense attorney told Media Matters the news outlet or anyone else who paid the prostitutes for their false story could face criminal charges that might involve wire fraud.
"Suppose all of these individuals lied and they were paid to lie and the advantage in some proprietary way flows to the people who paid them and there was a communication over U.S. or U.S and foreign communications facilities, you might make out a wire fraud," said Stuart Pierson, a Washington, D.C. attorney who specializes in white collar crime and media issues. "If there is a communication involving U.S. transmission communication facilities and the purpose of this lie and fraud is to adversely affect the proprietary interest of somebody in the United States or a U.S. Citizen."
A Department of Justice spokesperson declined to comment on any investigation that might be related to the reporting of the story.
Pierson and other attorneys agreed a defamation or libel civil charge is likely if it is found the Daily Caller knew the information was false, and is increased if it is found they paid someone to lie, or knew that someone was paid to lie.
Despite widespread recent criticism of the role conservative media outlets played in the 2012 election and its aftermath, most attendees at last week's Conservative Political Action Conference had a positive view of the current state of right-wing journalism.
The calls for reform of conservative media are unconvincing to journalists who have found that the current model has given them a large audience.
Mike Opelka, editor-at-large for Glenn Beck's The Blaze, said the popularity of conservative media proves that they are doing good work.
"Fox dominates the conservative cable media," he said. "We [The Blaze] are averaging 10 million uniques a month. I think it is on target for what we like. We are a center-right source and we think they like what we give them."
Dana Loesch, the conservative radio talk show host whose past work for the Breitbart family of conservative news websites helped generate appearances on CNN, Fox News and ABC News, also gave high marks to conservative outlets.
"I think they are doing a really good job," she said of her fellow right-wing media outlets. "It's a good market, I always think there is an appetite for conservative media because there are a lot of people, myself included, who think you don't get that perspective when you turn it on, CBS, NBC, the channels like that."
Their optimism comes at a time when numerous media voices, including several prominent conservatives, have raised questions about the state of conservative media following a 2012 election in which right-wing media outlets convinced their readers, viewers, and listeners that Mitt Romney was cruising towards a comfortable win over a villainous President Obama. Last week, American Conservative published an extensive piece critical of "groupthink" among "several conservative publications."
Similarly, in a February post at his influential Red State website, new Fox News contributor Erick Erickson criticized the conservative "echo chamber" for "trying so hard to highlight controversies, no matter how trivial" at the expense of basic reporting.
But these concerns, alongside a recent flurry of embarrassments (like the Breitbart.com "Friends of Hamas" debacle), were not shared by most at CPAC, who were quick to paint a rosy picture of their work in interviews with Media Matters.
Top conservative media voices spoke out on the need to keep stories accurate and in-depth, while at the same time citing some of the right-wing media's worst stumbles as points of honor during a panel discussion Friday at the Conservative Political Action Conference.
It has been a rough few months for the right-wing media. After a variety of observers pointed to its ineffectiveness during the 2012 election, it has come under fire again over the last month as major stories from The Daily Caller and Breitbart.com have imploded.
But such concerns were largely ignored during the CPAC panel titled "Survivor: Conservative Media," which was billed as an examination of the future of right-wing publications. This comes as little surprise, given that representatives from both the Caller and Breitbart.com were featured panelists.
Moderated by Scottie Hughes of the Tea Party News Network, the panel included Katie Pavlich, news editor at Townhall.com and a Fox News Contributor; Seton Motley, a Breitbart.com columnist; Keith Urbahn, co-founder of Javelin; and Lars Larson, a conservative radio talk show host.
While defending their past work, each appeared to espouse traditional journalistic values of accuracy, in-depth reporting and balance.
"Listen to what everyone else is saying, but don't be afraid to break from the pack," Larson said. "When there is a story, get on it, because there are too many stories that are a sleeper. Fast and Furious was a sleeper for a long time."
Larson referred to the botched ATF mission, which Pavlich and others had baselessly spun as a a conspiracy by the Obama administration to implement stronger gun laws.
American Conservative Union Chairman Al Cardenas defended giving a speaking slot at the organization's 2013 CPAC conference to Donald Trump while snubbing Republican New Jersey Gov. Chris Christie.
In response to questioning from Media Matters' Joe Strupp at a press conference, Cardenas said that despite Trump's history of racially inflammatory remarks and ongoing promotion of conspiracy theories about President Obama's birthplace, Trump had been invited to speak because "we can't have thirty people saying the same thing with the same backgrounds."


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I estimate Q4 cfps shud equal about 21c (using their exit and 9mos boepd for Q4 boepd and increased share count). Even with no growth in 2013 and WTI about $80-85 and AECO 1mo fwd remaining above $3, plus their hedges, this would mean easily maintaining a 2013 cfps of obviously 84c. However we are expecting growth, even with declines, and my pure spec is that 88cents would be min. So current sp reflects 3.3xcfps down from the annualised Q3 cfps accorded MEI ( using the $2.80 sp prior to latest results and lower share count) of 10! . What cfps do you think we might give this one right now? Less than 4x is darn cheap!!!
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It's a laudable effort that often gets more brickbats than bouquets. This year, when Finance Minister Pranab Mukherjee presents the Union budget in parliament on February 26, he will walking a tightrope between managing ballooning fiscal deficit and supporting economic recovery in Asia's third-biggest economy.
India Insight
Why should the government control inflation?
The 'reform agenda' understood as 'market-oriented reform' or giving more space to market mechanism in food and fuel economy seems to have been held up.
Is the media going overboard in its coverage of the Ambani feud?
The war of words between the billionaire Ambani brothers took an unexpected turn when younger sibling Anil offered an olive branch to elder brother Mukesh in a bid to resolve a feud over the split of the Reliance business empire in 2005.
Whose poor is poor?
"To define is to limit," wrote T.S. Eliot.
Indeed sometimes, to limit things, they just may have been defined in a particular manner.
Satyam — truth be damned?
If a stock dives 55 percent, is it time to go bargain hunting?
Absolutely not! At least that was the case with India's Satyam Computer Services after it shocked investors on Wednesday by disclosing most of its profits were cooked up.
India in 2008: The year that was
Yet another year is coming to an end and independent India's idea of being a republic is a year older. But is it any wiser?
Play safe, stay away from stocks
The world of equities seems to have opted for a bargain-basement sale. The BSE Sensex which scaled the dizzy heights of 21,000 points in January 2008 is today testing 10,000 and nobody is sure if the bottom has been found.
Fix politics before it hurts democracy
As a financial journalist, covering politics and parliamentary debate is sometimes part of my job. What I witnessed on Tuesday in parliament — wads of cash being flashed around inside the lowerhouse– is something I had never bargained for.
Whither shareholder activism?
July is the season for shareholder meetings, an annual rite of passage for Indian companies, with directors, shareholders and reporters trooping into large, badly-lit auditoriums to hear the chairman speak glowingly of the achievements of the past year, and a litany of woes from shareholders.
Crude realities for India's economy
Only last year Indian policymakers were showing off the strong fundamentals of the economy to the world and pressing for a seat at the high table of global fora. Everything was going well — high growth, a surging stockmarket and a lot of attention from global investors attention.


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Floats, lounges, water toys, lake toys, and water trampolines. Gander Mountain carries all types of water floats, lounges, water toys, lake toys and water trampolines for your enjoyment. We also have a large selection of pool and spa accessories. For fun on the lake and at the pool, shop for all your lake and pool toys, floats, lounges and water trampolines now! Our top brands include, Swimline, Aquaglide, Rave and more.
California Board Company 9' Soft Stand-Up Paddleboard Set
Paddleboard set with paddle, leash, and roof rack
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Includes wireless remote control
Gail Force Extra Thick Saddle Float
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Aquaglide Freefall Pontoon Slide
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Stays cool in the hot sun
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Overton's Colosseum Island, 8-person
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Open in the middle for swim in or out access
O'Brien 6-Person Party Lounge
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Includes 6 cup holders
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Original SlingKing Water Balloon Launcher
Launches balloons up to 75 yards
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100 biodegradable balloons
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Margaritaville Aqua Saddle
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Radar Cadence Soft Top Stand-Up Paddleboard With Adjustable ...
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Swimline SofSkin Floating Mattress
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Monday, September 17, 2007
Today's cd/Betcha Bottom Dollar
Wow, this is a great cd! These young women are bringing back the days of the Andrews Sisters. The album begins perfectly with Sisters (though they aren't). It continues with such selections as Java Jive, Sway, and newer ones like I Will Survive and Heart of Glass.
The producer of this album is Benoit Charest, who did the soundtrack for Les Triplettes de Belleville (The Triplets of Belleville), a movie I loved. You can hear his influence on the cd. Their second album comes out next month in the UK, and I'm not sure when in the US.
6 comments:
You are so right, they sing with such harmony and beauty!! I loved to hear the voices of the Andrew Sisters they too were amazing...ReplyDelete
Beverly :o)
Good music!!!!!ReplyDelete
Thanks, to both of you for stopping by to listen. I think you will really enjoy the album!ReplyDelete
Oooh, thanks for posting this! I love The Triplets of Belleville, and really enjoyed the track you posted.ReplyDelete
Oh they are great!ReplyDelete
Now that I am a grandmother, it seems that I am often late in replying to your most-appreciated comments. But I read them as soon as they come in, and I will write as soon as I can. Please do come back and check. I love these blogging conversations. A little addendum - I've just spent quite a long time catching up with dear notes you left me months ago!! I do hope you can get back to read them. And I'm trying to be much more prompt now!
Also, you may comment on any post, no matter how old, and I will see it.


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Super PAC spending in Michigan and beyond
Eve Troeh
Feb 21, 2012 Republican presidential candidates are spending millions on the state's airwaves. But those ads are more and more often not being paid for by official campaigns but by giant political action committees -- super PACs.
Where do campaign donations go?
Nancy Marshall-Genzer
Feb 21, 2012 Wealthy donors who contribute to political campaigns get lots of media attention -- but not nearly as much attention is paid to how that money gets spent.
The economy's looking up, but can Obama take credit?
Megan McArdle
Feb 16, 2012 Commentator Megan McArdle says no president has that much control over the economy.
The GOP candidates largely agree on what ails the country
Robert Reich
Feb 8, 2012 But commentator Robert Reich says they miss the cause.
Biggest war chest not necessarily deciding primaries
David Gura
Feb 8, 2012 Rick Santorum, the candidate who has raised the least amount of money, recently won three primaries. Does this mean money doesn't matter as much as we thought?
Missouri primary will cost millions, but not matter
Maria Altman
Feb 6, 2012 Missouri is holding its presidential primary tomorrow. Turnout is expected to be extremely low, mostly because the votes for GOP candidates won't count -- and it'll still cost taxpayers millions of dollars.
Facebook seeks money in IPO, campaigns use tech
John Moe
Feb 1, 2012 Everyone needs enormous piles of cash, evidently.
Nebraska manufacturers make dramatic comeback
David Gura
Jan 31, 2012 How employees at one Nebraska manufacturer pulled together to survive recession, and now the future seems brighter than ever.
What matters to Nebraska and Nevada in the election
David Gura
Interview with
Jan 31, 2012 The two states are vastly different in their economies. What they are concerned about, and what they're looking for in this upcoming election.
More from NASCAR CEO Brian France
Adriene Hill
Interview by
Jan 30, 2012 Heading into the Florida primary, we went to the CEO of NASCAR to get a glimpse at the state's economic situation.


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AXC 11 - Conway Conflict
Dec 11, 2010 at 7:00 PM
Arkansas Xtreme Challenge breaks new ground by having it's first Pro/Am MMA event in the city of Conway Arkansas at the Conway Expo Center! With AXC 10 being exposed to the entire country on HDNet fights, this show promises to be a major hit! Conway fighters will be featured as they take on some of the best fighters from all across the south! All VIP tickets have been selling out in previous shows, so don't delay and get your tickets now!
Sports : Genre: Grappling/Jiu-Jitsu,Judo,Karate,Kickboxing/Muay Thai,Mixed Martial Arts,Taekwondo,Wrestling
AXC 11 - Conway Conflict | 7:00 PM


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This page contains several photo portfolio galleries by Chamonix Mont Blanc based photographer Genyphyr Novak.
There are photo portfolios of winter and summer adventure sports events like skiing, mountaineering, hiking and trail running. There are galleries of mountain and landscape photography, the Swiss, Italian and French Alps. There are galleries of people photos with portraits of people, galleries of animal photography, galleries of alpine wild flowers, hiking photos, trekking photos and Mont Blanc photos. There are also photo portfolios of weddings as well as photos of every day life in Chamonix and archive photos from previously published editorial and news photography.


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The health symptoms too many young men ignore
The health symptoms too many young men ignore
Final Shot: Our Favorite Moments
Unlock your personal NFL Now stream by signing in to NFL.com
Daily Shot With Ali Wentworth
For most guys in their 20s and 30s, health concerns might seem like something in the far distant future. But gastroenterologist Dr. Roshini Raj says that young men should be aware of symptoms and behaviors that could indicate or lead to serious medical issues. Some health symptoms might seem commonplace but really need to be checked out, including acid reflux and heartburn. "So many people get heartburn every day," she says. "They don't think it's a big deal, but they could be causing significant damage to their esophagus, and in some cases esophageal cancer. Don't just ignore it." Dr. Raj emphasizes that younger men often think they are invincible and participate in a lot of risky behaviors, which can cause health problems. The biggest concern? "STDs," she said, explaining that some men might not be practicing safe sex. "Get screened if you've had any high-risk behavior." In addition to STD screenings, other important tests that all young guys should have done, said Raj, are a blood pressure check, a cholesterol screening, and a testicular exam. Having a beer gut or a potbelly can also be a cause for concern. "Studies have shown that abdominal obesity -- that's belly fat -- is an independent predictor of heart disease," Raj says. "Overall obesity is bad for you; abdominal obesity is even worse." To find out the No. 1 question that guys are too embarrassed to ask their doctor, check out this episode of "Daily Shot."
A look back at the greatest moments from this season of "Daily Shot," and a final scene you won't believe.
In this "lost episode" of "Daily Shot," Ali interviews her husband. Things get uncomfortable. Many months ago George Stephanopoulos came into the "Daily Shot" studio for an interview. So why hasn't it aired? While George is famous for asking hard-hitting questions on "Good Morning America," we discovered he doesn't like being on the other side of the interview table, especially when Ali is the one asking the questions. The "GMA" host did his best to be a good sport, but it's clear he wasn't altogether comfortable with his wife's "less formal" interview style or "loose interpretation of facts." That said, if you want to find out how often Ali embarrasses George or see how George rates himself against fellow handsome Greek John Stamos, check out this ... the penultimate episode of "Daily Shot"!
Top Tupperware salesperson Aunt Barbara helps Ali say goodbye with a tribute to the best past canceled shows.
On the new season of "Inside Amy Schumer" on Comedy Central, viewers can look forward to celebrity guests like Paul Giamatti of "Sideways" and "The Hangover Part II," Zach Braff of "Scrubs," Rachel Dratch of "30 Rock," and Parker Posey, among others. But the show's success doesn't mean it's easier the second time around for host and star Amy Schumer. "They gave us less money, so I'm also playing the extras," Amy jokes. Did she hook up with any of the famous guest stars who appear in Season 2? Nope. "I've never hooked up with anyone who could help my career," she says. "I've been sleeping my way down." Amy was quick to dismiss Ali's jealously over her TV success and upcoming movie, "Train Wreck," directed by Judd Apatow. "I'm lonely, and I don't have any time to enjoy my life," she said. To watch Amy play a hilarious round of "Which Is Worse?" with Ali, check out this episode of "Daily Shot."
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Sangha, Randeep MD*; Davies, Angela M. MD†; Lara, Primo N. Jr MD‡; Mack, Philip C. PhD‡; Beckett, Laurel A. PhD‡; Hesketh, Paul J. MD§; Lau, Derick MD‡; Li, Tianhong MD‡; Perkins, Natasha‡; Gandara, David R. MD‡
*Division of Medical Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada; †OSI Pharmaceuticals, Melville, New York; ‡Division of Hematology and Oncology, University of California, Davis Cancer Center, Sacramento, California; and §Lahey Clinic Medical Center, Burlington, Massachusetts.
Disclosure: The authors declare no conflicts of interest.
Address for correspondence: David R. Gandara, MD, University of California, Davis Cancer Center, 4501 X Street, Suite 3016, Sacramento, CA 95817. E-mail: firstname.lastname@example.com
Introduction: Epidermal growth factor receptor tyrosine kinase inhibitors given concurrently with chemotherapy do not improve patient outcomes compared with chemotherapy alone in advanced non-small cell lung cancer (NSCLC). On the basis of preclinical models, we hypothesized pharmacodynamic separation, achieved by intermittent delivery of epidermal growth factor receptor tyrosine kinase inhibitors intercalated with chemotherapy, as a reasonable strategy to deliver combination therapy.
Methods: A phase I dose-escalating trial using two scheduling strategies (arms A and B) was conducted in patients with advanced solid tumors to determine the feasibility of intermittent erlotinib and docetaxel. Phase II efficacy evaluation was conducted in an expanded cohort of patients with previously treated advanced NSCLC using arm B scheduling. Docetaxel was given every 21 days (70–75 mg/m2 intravenously) in both arms. In arm A, erlotinib was administered on days 2, 9, and 16 (600–1000 mg); in arm B, erlotinib was delivered on days 2 through 16 (150–300 mg). Patients without progression or unacceptable toxicity after six cycles continued erlotinib alone.
Results: Eighty-one patients were enrolled in this study (17 arm A; 25 arm B; and 39 at phase II dose). Phase I patients had advanced solid tumors and 22 with NSCLC (10 and 12 patients for arms A and B, respectively). Treatment was well tolerated for both arms, with dose-limiting toxicities including grade 3 infection and febrile neutropenia in arm A (maximum tolerated dose [MTD] of erlotinib 600 mg/docetaxel 70 mg/m2) and grade 4 rash, febrile neutropenia, grade 3 mucositis, and grade 3 diarrhea in arm B (MTD of erlotinib 200 mg/docetaxel 70 mg/m2). The MTD for arm B was chosen for phase II evaluation given the feasibility of administration, number of responses (one complete response and three partial responses), and achievement of pharmacodynamic separation. The response rate for patients treated at the phase II dose was 28.2%, and the disease control rate was 64.1%. Median progression-free and overall survival were 4.1 and 18.2 months, respectively. Common grade ≥3 toxicities were neutropenia (36%) and diarrhea (18%).
Conclusions: Pharmacodynamic separation using intercalated schedules of erlotinib delivered on an intermittent basis together with docetaxel chemotherapy is feasible and tolerable. Further studies using this approach together with interrogation of relevant molecular pathways are ongoing.
Platinum-based chemotherapy has long been the standard of care for patients with advanced non-small cell lung cancer (NSCLC). In recent years, new strategies integrating molecular-targeted therapies have modified the treatment paradigm. Inhibition of the epidermal growth factor receptor (EGFR) pathway with small molecule tyrosine kinase inhibitors (TKIs), such as erlotinib and gefitinib, was the first targeted therapeutics to demonstrate efficacy as single agents in NSCLC. A large phase III trial demonstrated a survival advantage of erlotinib compared with placebo in the second- or third-line setting.1 Importantly, this outcome was achieved in an unselected patient population with no requirement for tumor EGFR expression. Similarly, docetaxel chemotherapy is a well-established second-line therapeutic option, which has been shown to result in improved survival when compared with placebo or other chemotherapeutic agents.2
Despite preclinical data suggesting that EGFR-TKIs would have additive-to-synergistic effects when combined with an array of chemotherapeutic agents, four large randomized phase III trials combining erlotinib or gefitinib together with first-line platinum-based chemotherapy failed to increase efficacy when compared with chemotherapy alone.3–6 Multiple possible explanations for these unexpected and disappointing results have been offered, including lack of patient selection, especially in view of the subsequent discovery of activating mutations in EGFR. Alternatively, we have hypothesized a negative interaction between EGFR-TKIs and chemotherapy in cancers with wild-type EGFR, which may account for the lack of benefit of combination therapy in previous phase III trials.7 Preclinical models suggest that although EGFR-TKIs are cytotoxic in NSCLC cell lines harboring EGFR-activating mutations, inducing apoptosis through caspase-related mechanisms, they are primarily cytostatic in EGFR wild-type cell lines.8,9 We and others have shown evidence in support of sequence specificity and schedule-dependent interactions of EGFR-TKIs and chemotherapy, suggesting that strategies involving intermittent EGFR-TKI dosing between chemotherapy cycles to achieve pharmacodynamic separation might prove most efficacious.10–13 The hypothesized explanation for this phenomenon exists in the potential antagonism between targeted therapies and chemotherapy: EGFR-TKIs induce G1-phase cell-cycle arrest, which protects cells from the cytotoxic effects of cell-cycle phase-dependent chemotherapeutic agents.
To test this theory, we conducted a phase I/II study designed to assess the safety and feasibility of two different schedules intercalating intermittent erlotinib and docetaxel. On the basis of the phase I data, a single dosing schedule was used in the phase II efficacy evaluation.
Patients with histologically or cytologically confirmed advanced solid tumors treated with any number of prior chemotherapy regimens were eligible for the phase I portion of the trial. Eligibility for the phase II portion consisted of cytologically or histologically confirmed NSCLC, treated with no greater than one previous treatment for metastatic disease. Phase II patients must have had progressive or recurrent disease after platinum-based chemotherapy. Prior chemotherapy or radiotherapy must have been completed at least 4 or 2 weeks, respectively, before study entry, and all significant previous treatment-related toxicities had to be resolved. Additional eligibility criteria included age older than 18 years, life expectancy of more than 12 weeks, and an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2 for phase I and ECOG performance status of 0 and 1 for phase II. Adequate hematologic (absolute neutrophil count ≥1500/μl and platelet count ≥100,000/μl), renal (serum creatinine ≤1.5 mg/dl or a calculated creatinine clearance ≥50 ml/min), and hepatic function (serum bilirubin less than or equal to the institutional upper limit of normal and aspartate aminotransferases within 2.5 times the upper limit of normal) were required. Patients with asymptomatic treated brain metastasis (surgical resection or radiotherapy) were eligible if they were neurologically stable and had stopped taking steroids and/or anticonvulsants for a minimum of 4 weeks. Patients who had previously received EGFR-targeted therapy or docetaxel were excluded. Patients with clinically significant ophthalmologic abnormalities or other disorders that might increase the risk of corneal epithelial injury were excluded. Patients with preexisting peripheral neuropathy ≥grade 2 or who were pregnant were not eligible. Patients of childbearing potential were required to use a medically acceptable contraceptive. For phase II, no prior malignancy was allowed except for the following: adequately treated basal cell or squamous cell carcinoma of the skin, in situ cervical carcinoma, adequately treated stage I or II cancer in complete remission, or any other malignancy from which the patient had been disease-free for greater than 5 years. The Institutional Review Board at the University of California, Davis approved this study, which was conducted in accordance with federal and institutional guidelines.
The phase I dose-escalation portion of the trial was designed to determine feasibility, evaluate safety, and to recommend a phase II dose and schedule of intercalation for intermittent erlotinib and docetaxel. During the phase I portion, patients were treated on one of the two independently accruing treatment arms according to a predetermined dose-escalation schema (Figure 1). Patients were enrolled using a standard 3 + 3 design. Once accrual to the first dose level on treatment arm A was completed, treatment arm B was open for enrollment to its first dose level. Accrual was continued in an alternating "ping-pong" fashion between both arms. Although combined in a single trial, the intent was to simulate concurrently run phase I trials.
In arm A, docetaxel was administered intravenously on day 1 of a 21-day cycle and erlotinib was given weekly on days 2, 9, and 16. In arm B, docetaxel was given intravenously on day 1of a 21-day cycle and erlotinib was given on days 2 to 16. To decrease the frequency and severity of known docetaxel-induced toxicities such as hypersensitivity reaction, fluid retention, and cutaneous adverse events (AEs), all patients received dexamethasone 4 or 8 mg orally twice daily for 3 days, starting 12 to 24 hours before docetaxel infusion. Erlotinib was taken orally in the morning with 200 ml of water 1 hour before or 2 hours after meals. Treatment with both drugs continued in the absence of disease progression, provided patients were clinically benefiting and tolerating treatment. After six cycles of intermittent erlotinib and docetaxel, patients were permitted to continue with erlotinib monotherapy (Figure 1).
Three patients were treated per cohort for one cycle (21 days) with no intrapatient dose escalation. If no dose-limiting toxicities (DLTs) were recorded, treatment continued and three patients were treated in the subsequent cohort. However, if a patient developed a DLT, another three patients (for a total of six) were treated within that cohort for one cycle. If no additional DLTs were observed, dose escalation continued. Escalation was terminated when two or more patients experienced DLT attributable to study drug at any given dose level. DLT was defined as any of the following occurring within the first cycle of treatment: grade 4 thrombocytopenia; grade 3 thrombocytopenia associated with bleeding, transfusion requirement, or lasting greater than 7 days; febrile neutropenia or grade 4 neutropenia of greater than 7 days duration; grade ≥3 peripheral neuropathy; or any grade ≥3 nonhematological toxicity considered by the investigator to be clinically significant and related to study drug, except for alopecia or inadequately treated nausea, vomiting, and/or diarrhea. Toxicity was graded according to the National Cancer Institute Common Toxicity Criteria version 2.0. The maximum tolerated dose (MTD) was defined as the highest dose level at which no more than one patient experienced DLT when at least six patients were treated at that dose level and were assessable for toxicity.
On the basis of the phase I multiple-dosing portion of this study, treatment arm B dosing schedule was selected for the phase II portion of this trial. Patients received 70 mg/m2 of intravenous docetaxel on day 1 and 200 mg of oral erlotinib on days 2 through 16 of a 21-day cycle. Patients without progression could receive a maximum of six cycles of treatment and erlotinib monotherapy thereafter. Docetaxel dose reductions were required for patients with significant hematological or nonhematological toxicities in the preceding cycle. Grade ≥3 peripheral neuropathy required removal from the study. Erlotinib dose reductions were required for intolerable grade 2 or grade ≥3 cutaneous toxicity. Grade ≥2 diarrhea and nausea/vomiting despite appropriate loperamide or antiemetic use also required dose modification. Treatment delay of more than 3 weeks because of toxicity required removal of the patient from the study. Routine use of granulocyte colony-stimulating factors was permitted for the phase II portion of the study in accordance with American Society of Clinical Oncology guidelines.
Baseline imaging and hematology plus blood chemistry were obtained within 4 and 2 weeks of study entry, respectively. Baseline screening included a complete medical history, physical examination, list of concomitant medications, assessment of ECOG performance status, and body weight. Weekly complete blood counts with white blood cell differentiation were drawn, while blood chemistries were performed before each 21-day cycle. Exploratory pharmacokinetic analyses were performed in a limited subset of patients. AEs were evaluated on days 1 and 8 of the first cycle and before each subsequent cycle using the National Cancer Institute Common Toxicity Criteria version 2.0.
Tumor size was assessed through computed tomography every 42 days. RECIST were used to determine tumor response and disease progression. The primary objective of the phase II portion was to determine response rate (RR) of intermittent erlotinib combined with docetaxel when administered as second-line treatment in patients with advanced NSCLC who previously received one platinum-containing regimen. Progression-free survival (PFS), overall survival (OS), and safety were secondary objectives. Patient archival specimens and blood samples were submitted for exploratory molecular analyses.
For phase II, a one-stage design was used to test the null hypothesis that objective RR did not exceed 5% at a 0.05 level of significance. Target accrual was 38 patients, to provide 90% power to reject the null hypothesis if true objective RR was ≥20%. With a sample size of 38 patients, there was 90% certainty that at least one toxicity occurring as much as 6% time would be captured. Kaplan-Meier methods were used to determine PFS and OS.
Eighty-one patients were enrolled in this study. For phase I, 17 patients were accrued to treatment arm A and 25 patients for treatment arm B. In the phase II portion of the study, 39 patients with advanced NSCLC were treated. Baseline demographics and disease characteristics are outlined in Tables 1 and 2.
Five patients were accrued at the original dose of 1200 mg of erlotinib weekly and 70 mg/m2 of docetaxel, with two experiencing DLTs: one fatal sepsis and one patient with pulmonary embolism. At a revised dose level 1, three patients were enrolled with one patient experiencing DLT from febrile neutropenia (Table 3). An additional three patients were accrued to dose level 1 without DLT. Dose level 2 saw two of six patients with DLTs of febrile neutropenia and grade 3 infection. Although the MTD for treatment arm A was established at the revised dose level 1 of 600 mg erlotinib weekly and 70 mg/m2 of docetaxel on day 1 of each 21-day cycle, this dose schedule was not considered feasible for phase II evaluation.
One of three patients had a DLT of febrile neutropenia at dose level 1, and an additional three patients were enrolled at this dose level without DLT. Subsequently, dose level 2 was opened and three patients were treated without DLT. At dose level 5, two of three patients experienced DLTs of grade 3 diarrhea and febrile neutropenia. The dose level was de-escalated but, unexpectedly, further DLTs were then observed in patients at dose level 4 (grade 3 mucositis and febrile neutropenia) and dose level 3 (grade 4 infection and febrile neutropenia). Hence, the MTD for treatment arm B was established at dose level 2 of 200 mg erlotinib on days 2 through 16 with 70 mg/m2 of docetaxel day 1 of each 21-day cycle.
Thirty-seven patients were evaluable for response in the phase I portion of the trial. Twenty-one patients had NSCLC, and 16 patients had other solid tumor malignancies. Five patients were not evaluable for response and went off study after one cycle without repeat disease assessment. Of the five patients treated on arm A at the original dose level of 1200 mg erlotinib and 70 mg/m2 docetaxel, two patients with advanced NSCLC had stable disease (SD) as best response. Response data for patients with NSCLC are summarized in Table 4. In treatment arm A, six patients had SD, three each for dose levels 1 and 2. In treatment arm B, five patients had SD (one each in dose levels 1, 2, and 4; two for dose level 3), two had partial responses (PRs) (dose level 1), and a complete response was also observed in one patient (dose level 2).
Response data for patients with solid tumors other than NSCLC are summarized in Table 5. In arm A, SD was observed in patients with primary unknown (dose level 1) and prostate cancer (dose level 2). In arm B, two PRs were seen in patients with hepatocellular and bladder cancer (dose level 2), and SD was observed in patients with small-cell lung cancer (dose level 1), germ-cell malignancy (dose level 2), ovarian cancer (dose level 3), and in a patient with adenoid cystic cancer (dose level 4).
AEs for patients enrolled on treatment arms A and B were similar. Common grade ≥3 toxicities were hematologic, with neutropenia occurring most often (Table 6). Nonhematologic AEs were primarily grades 1 and 2 with rash, fatigue, and diarrhea being the most common AEs. One patient experienced grade 4 rash, and three patients experienced grade 3 diarrhea.
Nadir plasma concentrations of erlotinib and its primary metabolite (OSI-420) were assessed in five patients in arm B, before their second cycle of docetaxel (day 21) to ascertain if the goal of pharmacodynamic separation was achieved.14 With this erlotinib dosing schedule of days 2 through 16, both erlotinib and OSI-420 were either undetectable (below limit of quantitation <1.00 ng/ml) or far below therapeutic levels (estimated 183 ng/ml for wild-type EGFR and 66 ng/ml for the L858R EGFR mutation) in four of five cases sampled (Table 7).15 These subtherapeutic plasma concentrations prevent potential antagonism between erlotinib and subsequent docetaxel dosing, supporting the concept of pharmacodynamic separation. We have previously demonstrated analogous findings using a similar intercalated design with erlotinib and pemetrexed.16 In the one outlier (erlotinib level 320 ng/ml), continued dosing of erlotinib beyond the protocol-specified stop date is suspected.
Treatment arm B was selected for further investigation in the phase II portion of the study given the feasibility of administration, promising number of responses, and achievement of pharmacodynamic separation. Erlotinib 200 mg was given daily for days 2 through 16, and docetaxel 70 mg/m2 was administered on day 1 of each 21-day cycle to 39 patients with advanced NSCLC who had progressed after a platinum-containing regimen.
Best response to therapy is shown in Table 8. The overall RR was 28.1%, and the disease-control rate was 64.1%. Although most of patients did not have tissue available for EGFR mutation analysis, we tested circulating tumor DNA in plasma for the presence of EGFR mutations.17 Two of the patients with complete response and four of nine patients with PR possessed EGFR mutations. Median PFS was 4.1 months (Figure 2). The 1-year PFS was 17.9%. Median OS was 18.2 months, and survival rates at 1 and 2 years were 58.9% and 38.5%, respectively (Figure 3).
Table 9 shows grade ≥3 treatment-related AEs for the subset of patients treated at the phase II dose (n = 39). Anemia and thrombocytopenia were common, but these were predominantly grade 1 or 2 toxicities with only one patient experiencing grade 3 thrombocytopenia. Neutropenia was common and occurred in 46% of patients and tended to be a grade 3 or 4 toxicity (36%); four patients (10%) developed febrile neutropenia. The most common nonhematological toxicities (grade ≥1) were diarrhea (79%), rash (77%), and fatigue (69%). Although 18% of patients had grade ≥3 diarrhea despite optimal preventative measures with loperamide, supplemental fluids, and other supportive measures, no patient experienced a grade ≥3 rash. The most common AEs resulting in dose reduction were diarrhea or intolerable grade 2 rash. There were no treatment-related deaths on the phase II portion of this study.
Chemotherapy plays a crucial role in the treatment of most stages of NSCLC. Likewise, agents targeting the EGFR, particularly the TKIs, erlotinib and gefitinib, have proven their importance in the treatment paradigm for advanced NSCLC. Erlotinib is approved for second- and third-line therapies, and, now, in the era of personalized medicine, first-line EGFR-TKI treatment is considered a standard of care for patients with cancers possessing an EGFR mutation.1,18–20 Although the appeal of combining traditional cytotoxic chemotherapy with biological therapeutics is understandable, four large randomized phase III trials of chemotherapy with or without an EGFR-TKI in patients with unselected advanced NSCLC did not demonstrate improvement in clinical outcomes.3–6 Moreover, combinations of chemotherapy and other "targeted" small-molecule inhibitors have generally been unsuccessful in NSCLC. In contrast, monoclonal antibodies such as bevacizumab and cetuximab have shown improved efficacy when combined with chemotherapy, perhaps because of inherent differences in mechanisms of action.21–23
In this study, we report a phase I/II trial exploring a combination strategy based on pharmacodynamic parameters together with supporting preclinical data. We and others have previously reported that pretreatment with erlotinib can result in a G1 arrest, abrogating the cytotoxicity of cell-cycle-specific chemotherapy.8,24 In our studies, a sequence of M-phase-specific docetaxel followed by erlotinib exhibited the greatest levels of apoptosis and was superior to the reverse sequence (erlotinib followed by docetaxel). We hypothesized that to extend these observations to the clinic, an erlotinib dose schedule intercalating intermittent delivery between docetaxel cycles would attain pharmacodynamic separation, abrogating negative cell-cycle-specific interactions of these agents.
Two erlotinib dose schedules were used in the phase I portion of this trial. Treatment arm A used high-dose erlotinib administered weekly with docetaxel. Weekly erlotinib at doses ≥600 mg result in high peak plasma levels within 4 hours.25 With a half-life of 36 hours, plasma levels from weekly therapy would be expected to be undetectable before the end of the 8-day intercalated dosing interval, allowing pharmacodynamic separation from subsequent docetaxel administration. In our trial, patients in arm A were unable to tolerate a weekly dose higher than 600 mg together with docetaxel 70 mg/m2, a cumulative erlotinib dose considerably lower than that which could be given in arm B (MTD, erlotinib 200 mg days 2 through 16 and docetaxel 70 mg/m2). Thus, the arm B schedule was chosen for further phase II efficacy evaluation.
For phase II, 39 patients with advanced NSCLC who had progressed after a platinum-containing regimen were treated with erlotinib 200 mg days 2 through 16 and docetaxel 70 mg/m2 day 1 on a 21-day cycle. Overall RR was 28.1% and disease-control rate was 64.1%. Encouragingly, median PFS was 4.1 months and OS was 18.2 months. In comparison, the BR.21 phase III trial demonstrated that patients with advanced NSCLC treated with erlotinib monotherapy after failing one or two prior chemotherapy regimens had a RR of 8.9% and median PFS and OS of 2.2 months and 6.7 months, respectively.1 Docetaxel, as second-line therapy, showed a median survival of 7.0 months in the TAX 317 trial.2 Although our results cannot be directly compared with the phase III trials described earlier in the text, the response and survival outcomes are favorable.
As previously described, EGFR-activating mutations were identified by means of an allele-specific polymerase chain reaction assay (Scorpion-amplification refractory mutation system) of circulating DNA in plasma in some patients on this trial.17 The presence of an EGFR mutation correlated significantly with improved tumor response and PFS in patients with NSCLC treated with intermittent erlotinib and docetaxel. However, the use of docetaxel in this intercalated schedule did not seem to reduce erlotinib activity in patients possessing EGFR mutations. In addition, patients with wild-type EGFR also showed benefit.
In conclusion, this study describes clinical application of a model of pharmacodynamic separation designed to overcome hypothesized negative interactions of concurrent administration of erlotinib and chemotherapy. Others have recently reported using this approach to administer EGFR-TKIs and other chemotherapeutic regimens. For example, in the FASTACT trial, Mok et al.26 demonstrated improved RR and PFS in patients receiving intercalated gefitinib plus gemcitabine-carboplatin versus those randomized to chemotherapy alone. A sequential approach of administering chemotherapy before therapy with an EGFR-TKI is a potential alternative design of overcoming antagonism. One such study, SATURN, showed an improvement in survival in an unselected population of patients demonstrating disease control after treatment with four cycles of platinum agent-based chemotherapy followed by erlotinib. Whether an intercalated or sequential model is more efficacious in achieving pharmacodynamic separation will require further exploration.27
Considering the inherent myelosuppression associated with docetaxel in previously treated patients, in our own studies in second-line therapy for NSCLC, we are currently evaluating a similar strategy with intercalated erlotinib and pemetrexed.16 Further studies exploring pharmacodynamic separation are ongoing.
This article has been cited 2 time(s).
Erlotinib; Docetaxel; Pharmacodynamic separation; Non-small cell lung cancer; Phase II
© 2011International Association for the Study of Lung Cancer
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And here we have it: yet another hair change-up from Emma Stone! The star, who went returned to her red roots back in March, was been generally committed to a more sideswept style for the premiere tour of her latest movie, The Amazing Spider-Man 2. But on Thursday night in New York City, Stone didn't just update her color (with lighter ombré highlights), she added blunt-cut bangs, which she styled with loose, tousled waves.
What do you think of Emma Stone's new beauty look?


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Part 4 of Getting a Spacelift, featuring C.C. Culver, former NASA mission controller, motivational speaker with International Stars, and ticket holder for a seat on Virgin Galactic's SpaceShipTwo. You can contact her at internationalstars [at] comcast.net
Big Picture Science – Getting a Spacelift: C.C. Culver
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