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|FDG uptake in primary squamous cell carcinoma of the head and neck. The relationship between overexpression of glucose transporters and hexokinases, tumour proliferation and apoptosis.
MedLine Citation:
|PMID: 21052609 Owner: NLM Status: In-Data-Review
|Aim: This study aimed at assessing the relationship between over-expression of glucose transporters and hexokinases, tumour proliferation and apoptosis corrected for cellularity and partial volume corrected (pvc) FDG SUV values in primary squamous cell carcinoma of the head and neck (pSCCHN). Patients, methods: In 27 consecutive patients suffering from pSCCHN, FDG SUVmax and mean pvc values of the primary tumour were derived from a pre-surgical routine staging FDG PET/CT examination. GLUT-1, GLUT-3, HK-1, HK-3 expression, tumour proliferation (Ki-67 staining) and the number of apoptotic cells (cleaved caspase-3 staining), corrected for tumour cellularity, were subsequently assessed on the corresponding post-surgically obtained biopsies and tumour specimens. FDG SUVmax and mean pvc values of pSCCHN were correlated with the corresponding histological findings. Results: FDG SUV max and mean pvc values correlated significantly: with GLUT-1 scores r = 0.408 (p = 0.04) and r = 0.439 (p = 0.03) as well as with the number of apoptotic cells r = 0.529 (p = 0.008) and r = 0.484 (p = 0.017). The number of apoptotic cells also correlated to GLUT-3 scores: r = 0.62 (p = 0.001) and GLUT-1 scores r = 0.528 (p = 0.008). Conclusion: FDG SUV pvc proved significantly related to GLUT-1 expression by tumour cells and to the absolute number of apoptotic cells. The latter finding warrants further exploration and confirmation by additional studies.
|P Deron; C Vangestel; I Goethals; A De Potter; M Peeters; H Vermeersch; C Van de Wiele
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Publication Detail:
|Type: Journal Article Date: 2010-11-05
Journal Detail:
|Title: Nuklearmedizin. Nuclear medicine Volume: 50 ISSN: 0029-5566 ISO Abbreviation: Nuklearmedizin Publication Date: 2011
Date Detail:
|Created Date: 2011-02-21 Completed Date: - Revised Date: -
Medline Journal Info:
|Nlm Unique ID: 7609387 Medline TA: Nuklearmedizin Country: Germany
Other Details:
|Languages: eng Pagination: 15-21 Citation Subset: IM
|Philippe Deron, M. D., Ghent University Hospital, Department of Head and Neck Surgery, De Pintelaan 185, 9000-B Gent, Belgium, Tel. +32/93 32 39 90, Fax +32/93 32 39 35, E-mail: email@example.com.
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|MeSH Terms
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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Cardinals safety Rashad Johnson lost the tip of his middle finger against the Seahawks in Week 3. Johnson missed Week 4's game, and it looks he will be sidelined even longer.
Pro Football Talk via Fox Sports and SiriusXM NFL Radio, report that Bruce Arians said Johnson was taken out of practice after hitting his casted hand. The Cardinals fear Johnson could lose more of the finger, if he continues to be put at risk.


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This is the January 10, 2013 news archive. View today's Diamondbacks rumors and news.
Justin Upton rejects possible trade to Mariners
PHOENIX (AP) A person with knowledge of the situation says Arizona Diamondbacks outfielder Justin Upton has vetoed a trade to the Seattle Mariners.Share Tweet
Source: Justin Upton Rejects Trade To SeattleJan 10ESPN.com senior MLB writer Jerry Crasnick has the latest on Diamondbacks outfielder Justin Upton, who exercised his no-trade clause in his contract to reject a proposed deal that would have sent him to the Mariners.
Sports Columnists
NFL playoffs -- John Clayton's First and Goal: Divisional roundJan 10Six quarterbacks have divvied up the past nine Super Bowl wins. Will we see a fresh face this year?
Peter King: NFL Playoffs Divisional Round PicksJan 10Peter King: NFL Playoffs Divisional Round Picks
Greg Oden, former No. 1 overall pick, plans to resume playing career - sou…Jan 10Former No. 1 overall pick Greg Oden has decided to resume
Adande: NBA basketball might return to SeattleJan 10What would we miss about the Sacramento Kings? What does it mean for Seattle?


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Lessons from Mourning
1Better is a good reputation than precious oil and the day of death than the day of birth.
2Better to go to a house of mourning than to go to the house of feasting, since that is the end of all mankind and the living should take it to heart.
3Grief is better than laughter, for though the face is sad, the heart may be glad.
4The heart of the wise is in a house of mourning, but the heart of fools is in a house of pleasure.
Wisdom Better Than Folly
5Better to hear a rebuke from the wise than to listen to the song of fools.
6For like the crackling of thorns under a pot, so is the laughter of the fool. This too is vapor.
7For extortion drives a wise man crazy, and a bribe corrupts the heart.
8Better the end of a matter than its beginning. Better a patient spirit than a proud one.
9Do not be quickly provoked in your spirit, for anger settles in the bosom of fools.
10Do not say, Why were the old days better than these? For it is not from wisdom that you ask about this.
11Wisdom is as good as an inheritance, and even better for those who see the sun.
12For wisdom is a shelter as money is a shelter, but the advantage of knowledge is this: wisdom preserves the life of the one who possesses it.
13Consider the work of God, for who can straighten what He has bent?
14In a time of prosperity, prosper! But in a time of adversity, consider: God has made one as well as the other. Therefore man cannot discover anything about his future.
Avoid Extremes
15During my fleeting days I have seen both of these things: sometimes a righteous one perishes in his righteousness and sometimes a wicked one lives long in his wickedness.
16Do not be overly righteous nor overly wise why confound yourself?
17Do not be overly wicked and do not be a fool why die before your time?
18It is good to grasp the one and not withdraw your hand from the other. For the one who fears God will escape both extremes.
19Wisdom makes a wise man stronger than ten rulers in a city.
20Surely there is not a righteous person on earth who does what is good and doesnt sin.
21Also, do not pay attention to every word people say, otherwise you might hear your servant mocking you
22for your heart knows that many times you too have mocked others.
23All this I have tested with wisdom and I said, I determined to be wisebut it was far from me.
24Whatever it may be, it is far off and very profoundwho can fathom it?
25So I turned my heart to understand, to search and seek out wisdom and an explanation of things and to know the stupidity of wickedness and madness of folly.
26I find more bitter than death the woman who is a snare, whose heart is a trap, and whose hands are chains. He who pleases God will escape her, but a sinner will be captured by her.
27Look, said Kohelet, I have discovered this while adding one thing to another to find the scheme of things
28which my soul is still seeking, but not findingI found one upright man among a thousand, but one upright woman among them all I have not found.
29Only this have I discovered: God made mankind upright, but they went seeking after many schemes.
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Location: The Netherlands > North Holland Province > Amsterdam > Centrum , Dam Square
Ranked #110 of 326 B&Bs / Inns in Amsterdam
Number of rooms: 2
- Official Description (provided by the hotel):
- Special price for January and February!!This is one of two studios I am renting out in the same building. If you are looking for a place for four people this could also be ideal! This studio is located on the second floor of the building and right in the middle of the center of Amsterdam. Just around the corner of the lively part of Amsterdam. Nearby everything in town: museums, shops, clubs, bars and restaurants. Public transport is really around the corner. The central station is 15 minutes walking distance and by tram it will only take you 5 minutes (tram 1, 2 and 5). The famous/oldest cafe in Amsterdam is right in front.The studio is a comfortable place to stay. The beds are heavenly, as you can see in my reviews.What's in the private studio?: • Comfortable double bed • Kitchenette with fridge, tea cooker, Nespresso \ machine • Private shower and toilet • Windows are double, so almost no noise from outside • Free WIFI • Free use of washing machine and dryerOn walking distance of: • The Central Station • The Van Gogh Museum • The Anne Frank House • The Rijksmuseum • The Stedelijk museum • The Hermitage • The Leidseplein • The Rembrandts Plein • The shopping streets: Kalverstraat, Leidsestraat or the "Negen Straatjes" • etc. Etc.Etc.Breakfast can be served upon request for €15 per person per day.USP: Great location, beautiful building, great bed, clean room and a host that does everything in her power to let her guests leave satisfied and xperience a stay in Amsterdam which is above expectations ... more less