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Publications (20)86.78 Total impact
Article: Gene therapy for high grade gliomas[Show abstract] [Hide abstract]
ABSTRACT: High grade gliomas in adults are devastating diseases, with very poor survival despite their lack of distant metastases. Local treatments, such as surgical resection and stereotactic radiosurgery, have been most successful, whereas systemic therapy (for example, chemotherapy and immunotherapy) have been rather disappointing. Several gene therapy systems have been successful in controlling or eradicating these tumours in animal models and are now being tested as a logical addition to current clinical management. This review describes the gene therapy clinical protocols that have been completed or that are ongoing for human gliomas. These include the prodrug activating system, herpes simplex thymidine kinase (HSVtk)/ganciclovir (GCV), utilising either retrovirus vector producer cells or adenovirus vectors; adenovirus mediated p53 gene transfer; adenovirus mediated IFN-beta gene transfer and oncolytic herpes virus and adenovirus vectors. To date, all of the clinical studies have used direct injection of the vector into the glioma. The Phase I clinical studies have demonstrated low to moderate toxicity and variable levels of gene transfer and in some cases anti-tumour effect. Future directions will rely upon improvements in gene delivery as well as gene therapies and combinations of gene therapy with other treatment modalities.Expert Opinion on Biological Therapy 04/2001; 1(2):239-52. DOI:10.1517/147125220.127.116.11 · 3.74 Impact Factor
Article: Eck, SL, Alavi, JB, Judy, K, Phillips, P, Alavi, A, Hackney, D et al.. Treatment of recurrent or progressive malignant glioma with a recombinant adenovirus expressing human interferon- (H5.010CMVhIFN-): a phase I trial. Hum Gene Ther 12: 97-113Human Gene Therapy 02/2001; 12(1):97-113. DOI:10.1089/104303401451013 · 3.76 Impact Factor
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ABSTRACT: An unusual cause of abdominal soft-tissue masses is accessory splenic tissue. The Tc-99m-sulfur colloid liver-spleen scan is a valuable adjunct in making this diagnosis. This report describes a 47-year-old man who had an abdominal magnetic resonance imaging (MRI) scan as part of a pretransplant evaluation and was found to have multiple soft-tissue masses in the posterior aspect of his abdomen. His history was pertinent for a traumatic rupture of the spleen at the age of 12 years, for which he required a splenectomy. He had no symptoms or physical findings to indicate a lymphoproliferative disorder or other malignant process. His peripheral blood smear was remarkable for the absence of Howell-Jolly bodies. The nuclear scan confirmed the presence of uptake in the soft-tissue masses seen on MRI scan. This finding supports our diagnosis of splenosis in a man with a history of traumatic splenic rupture as a child.American Journal of Clinical Oncology 11/2000; 23(5):506-8. DOI:10.1097/00000421-200010000-00015 · 3.06 Impact Factor
Article: Contralateral Cortical Diaschisis in a Patient With Cerebellar Astrocytoma After Radiation Therapy[Show abstract] [Hide abstract]
ABSTRACT: Contralateral cerebellar diaschisis, hypometabolism in the cerebellum contralateral to a cortical lesion, is a well described phenomenon in patients with stroke and brain tumor. However, few reports exist of patients with cerebellar lesions with the finding of contralateral cortical hypometabolism. The authors present a case of a patient with a right cerebellar astrocytoma after surgical resection and radiation therapy in which fluorine-18 fluorodeoxyglucose positron emission tomographic imaging, performed to rule out recurrent tumor, revealed global hypometabolism in the left cerebral cortex. The concept of contralateral cortical diaschisis and possible mechanisms and clinical implications are reviewed.Clinical Nuclear Medicine 07/2000; 25(6):431-3. DOI:10.1097/00003072-200006000-00008 · 3.93 Impact Factor
Article: Gene therapy for malignant gliomas[Show abstract] [Hide abstract]
ABSTRACT: Malignant gliomas are attractive targets for gene therapy because of their relatively well-localized distribution. Several new strategies have been devised that target different aspects of glioma biology. Gene transfer can be used to synthesize chemotherapy drugs that block DNA synthesis within these highly mitotic tumors. New genes can be introduced that restore the functions of mutated tumor suppressor genes or block the molecular pathways needed for tumor angiogenesis. Alternatively, the immune response to these tumors can be augmented by the local production of cytokines. Finally, viruses themselves can be used as tumoricidal agents by designing viruses that selectively replicate and destroy tumor cells. The advantages and limitations of these approaches are discussed in the context of their possible application to the treatment of these highly lethal malignancies.Hematology/Oncology Clinics of North America 07/1998; 12(3):617-29. DOI:10.1016/S0889-8588(05)70011-3 · 2.30 Impact Factor
Article: Detection of Unsuspected Recurrent Lymphoma With Fluorodeoxyglucose-Positron Emission Tomographic Imaging After Induction Chemotherapy[Show abstract] [Hide abstract]
ABSTRACT: We performed a fluorodeoxyglucose-positron emission tomographic (FDG-PET) study on a patient who had high-grade lymphoma thought to be in complete remission. The patient underwent the PET study before being considered for high-dose consolidation therapy because he was thought to be at high risk for relapse. The whole-body FDG-PET study revealed an unsuspected hypermetabolic mass in the lower spine that was not visualized on computed tomographic (CT) scanning. The other laboratory values were normal, with the exception of mild lactate dehydrogenase elevation. Two weeks later, the patient developed low back pain, and magnetic resonance imaging showed a 2-cm paraspinal mass at the level of L4. Bone-marrow biopsy confirmed recurrent lymphoma. Remission was not achieved after another chemotherapy regimen. Fluorodeoxyglucose-positron emission tomography can be helpful in the restaging of lymphoma patients after induction chemotherapy and may help to detect early recurrence in selected situations.American Journal of Clinical Oncology 04/1998; 21(2):126-8. DOI:10.1097/00000421-199804000-00005 · 3.06 Impact Factor
Article: 74 Longterm neurocognitive sequellae of a prospectively followed cohort of low grade tumor patients treated by conformal irradiationInternational Journal of Radiation OncologyBiologyPhysics 12/1996; 36(1):195-195. DOI:10.1016/S0360-3016(97)85415-6 · 4.26 Impact Factor
Article: Treatment of Advanced CNS Malignancies with the Recombinant Adenovirus H5.010RSVTK: A Phase I Trial. University of Pennsylvania Medical Center, Philadelphia[Show abstract] [Hide abstract]
ABSTRACT: Primary CNS malignancies are responsible for approximately 12,000 deaths annually in the United States. There has been little change in the outcome for adults with malignant brain tumors over the past few decades, despite improvements in surgical techniques and advances in radiation therapy. These tumors are uniformly fatal one to two years after diagnosis. The morbidity and mortality of this disease arise from the effects of a locally invasive, non-metastasizing lesion. The patients may suffer from seizures, paralysis, incoordination, aphasia, confusion, memory loss, sensory deficits or visual loss, depending on the regions of the brain affected. In addition, they usually require large doses of corticosteroids early and late in their illness, and may experience disabling side effects of this treatment, such as edema, proximal myopathy, diabetes, fungal infections or deep vein thrombosis. Few patients in the older age group are able to work after the diagnosis. Most of the patients are incapable of self-care for several months before death. The localized transfer of new genes into cancer cells potentially permits the expression of proteins with specific biologic functions that may provide a means to alter the biology of tumor growth through a variety of mechanisms including increasing tumor immunogenicity, inducing the local expression of toxic agents, and sensitization of tumors to chemotherapeutic agents. Gene therapy with the transfer of the drug susceptibility gene Herpes virus thymidine kinase (HSV-TK) has shown promise in a number of animal models, including CNS tumors. This study will evaluate the use of adenovirus-mediated transfer of the HSV-TK gene into primary human brain tumors followed by systemic treatment with ganciclovir. The goals of this phase I study are to evaluate the overall safety and efficacy of this treatment and to gain insight into the parameters that may limit the general applicability of this approach. In this phase I study, patients with recurrent gliomas will receive stereotactic-guided injections of the virus into the brain tumor, followed by intravenous ganciclovir for 14 days. Patients eligible to undergo a palliative debulking procedure will receive the same treatment followed by resection on day 7. At the time of resection a second dose of virus will be administered intra-operatively into the residual, unresectable portion of the tumor, and intravenous ganciclovir will be continued for additional 14 days. Tissue removed at the time of resection will be analyzed for evidence of adenovirus infection, thymidine kinase expression and signs of inflammation. The size and metabolic activity of all tumors will be followed by volumetric MRI scans and Position Emission Tomography Scans, respectively. Patients will be enrolled in groups of three, with each group receiving successively larger doses of adenovirus. This study will quantify the toxicity of this therapy, and provide evidence as to the duration of transgene expression and virus induced inflammation.Human Gene Therapy 09/1996; 7(12):1465-82. DOI:10.1089/hum.1996.7.12-1465 · 3.76 Impact Factor
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ABSTRACT: Two cases of postsurgical brain tumor evaluation in which MRI was inconclusive are discussed. Functional imaging techniques, such as FDG-PET and 201TI SPECT, were used in both cases for distinguishing radiation necrosis from tumor recurrence. These methods proved to be complimentary. For Patient 1, FDG-PET showed more limitations compared to 201TI SPECT. FDG-PET results on the other hand, were consistent with the final diagnosis and the SPECT image was false positive for tumor recurrence in Patient 2.Journal of Nuclear Medicine 02/1995; 36(1):159-64. · 6.16 Impact Factor
Article: Comparison of PET-FDG and SPECT TL-201 in distinguishing radiation necrosis from tumor recurrence in the brain[Show abstract] [Hide abstract]
ABSTRACT: CT and MRI scans are quite sensitive in detecting brain tumors. However, with both imaging techniques limitations have been reported in distinguishing tumor recurrence from radiation necrosis. Metabolic imaging methods such as PET-FDG and SPECT T1-201 have been utilized for differentiating radiation necrosis from tumor recurrence. However, no study was to compare PET-FDG and SPECT T1-201 in primary brain tumors.Journal of Nuclear Medicine 04/1994; 35(Suppl.5). · 6.16 Impact Factor
Article: Detection and semi-quantitative measurement of lung cancer metabolic activity by whole body PET[Show abstract] [Hide abstract]
ABSTRACT: Conventional radiologic and nuclear medicine techniques have been shown to have a limited role in the staging and monitoring of disease activity in patients with lung cancer. Both qualitative and semi-quantitative position emission tomography (PET) using the F-18 FDG technique have been applied to determine the clinical utility of whole body PET-FDG imaging in lung cancer. Nineteen whole body FDG PET scans were performed in 18 patients; 17 with lung cancer (15 non-small cell and 2 small cell) and 1 with squamous cell carcinoma of the trachea.Journal of Nuclear Medicine 04/1994; 35(Suppl.5). · 6.16 Impact Factor
Article: Effects of radiation therapy on adult brain behavior: Evidence for a rebound phenomenon in a phase 1 trial[Show abstract] [Hide abstract]
ABSTRACT: Although radiotherapy (XRT) is a necessary course of treatment to prolong life expectancy in patients with many types of brain neoplasms, it has damaging effects that are little understood. We used a comprehensive neuropsychological battery to evaluate five patients with low-grade brain tumors prior to XRT and then at 3-month intervals up to 9 months postcompletion of XRT. We matched patients by age and education with six normal control subjects to assess baseline impairment. In intrasubject comparisons, we examined change over time postcompletion of XRT. In spite of varying locations of tumors, all patients showed deterioration in long-term memory at a mean of 1.5 months postcompletion of XRT. Patients also consistently demonstrated a rebound effect between means of 4.7 and 7.6 months post-XRT. We found no changes over time in working memory, attention, visuospatial processes, or on any other neuropsychological test with the exception of information-processing speed, which quickened over time. Functional measures of fatigue and mood did not correlate significantly with the long-term memory scores. Long-term memory appears sensitive to the proposed white matter changes thought to be the mechanism for the early-delayed effects of XRT. Our findings suggest a neurobehavioral model for studying the effects of XRT on brain functioning.Neurology 11/1993; 43(10):1961-5. DOI:10.1212/WNL.43.10.1961 · 8.29 Impact Factor
Article: New grading system of cerebral gliomas using positron emisson tomography with F-18 fluorodeoxyglucose[Show abstract] [Hide abstract]
ABSTRACT: Positron emission tomography (PET) using fluorine-18 (18F)-fluorodeoxyglucose (FDG) has been reported to be a powerful diagnostic and prognostic tool in patients with primary brain tumors. This study was undertaken to compare the prognostic value of: (1) visual grading of [18]FDG uptake in the tumor, (2) the absolute glucose metabolic rate of the tumor (TMRglc), (3) the ratio of glucose metabolism between the tumor and whole brain (T/WB) and (4) between the tumor and contralateral cerebellum (T/CBL). Each of these four parameters was correlated with the survival time in 20 patients with malignant cerebral gliomas. Excellent correlation was obtained with visual grading and reasonably good correlation was obtained with T/WB or T/CBL, but TMRglc alone was only a fair prognostic indicator. Thus, visual grading provides a qualitative analysis and T/WB provides a semi-quantitative analysis neither of which requires arterial blood sampling for quantification of absolute metabolic rates for glucose.Journal of Neuro-Oncology 03/1991; 10(1):85-91. DOI:10.1007/BF00151249 · 3.07 Impact Factor
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ABSTRACT: Short communication.Radiology 01/1991; 177(3):617-8. DOI:10.1148/radiology.177.3.2243960 · 6.87 Impact Factor
Article: Magnetic resonance and fluorine-18 deoxyglucose imaging in the investigation of a spinal cord tumor.Journal of Nuclear Medicine 04/1990; 31(3):360-4. · 6.16 Impact Factor
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ABSTRACT: Positron emission tomography (PET) studies have been performed using 18-F-fluorodeoxyglucose in 29 adult subjects with primary brain tumors. Seventy-two percent of the patients were treated previously. The glucose metabolic state in the lesions was increased in 16 patients, and was normal or decreased in 13 patients. The hypermetabolic tumors tended to behave in a more malignant fashion. Patients with hypermetabolic tumors had a median survival of 7 months after PET scan, compared to 33 months for those with hypometabolic lesions. Among the high-grade glioma patients, the PET results separated them into a good prognosis group (hypometabolic, with 78% 1-year survival) and a poor prognosis group (hypermetabolic, with a 29% 1-year survival after PET). These results suggest that glucose metabolic studies may provide an independent measure of the aggressiveness of a brain tumor, and may supplement pathologic grading.Cancer 10/1988; 62(6):1074-8. DOI:10.1002/1097-0142(19880915)62:63.0.CO;2-H · 4.89 Impact Factor
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ABSTRACT: We studied cerebellar metabolism in 118 subjects including young and elderly controls and patients suffering from stroke, supratentorial brain tumor and Alzheimer's disease using fluorine-18 fluorodeoxyglucose ([18F]FDG) and position emission tomography (PET). Alzheimer's disease and normal aging did not alter mean cerebellar metabolism. In stroke and tumor mean cerebellar metabolism was lower in the hemisphere contralateral to the supratentorial lesion. In tumor bilaterally significant reductions in absolute cerebellar metabolism also were noted, unlike stroke. Primary sensory stimulation did not alter absolute or relative cerebellar metabolism. These results show that absolute and relative values for cerebellar metabolism vary depending on the process under study. Thus analysis schemes employing normalization of regional metabolic data to cerebellar values may be subject to error.Journal of Nuclear Medicine 12/1987; 28(11):1667-70. · 6.16 Impact Factor
Article: Sequential computerized tomography and positron emission tomography studies in a patient with malignant glioma[Show abstract] [Hide abstract]
ABSTRACT: Computerized tomography (CT) and positron emission tomography (PET) using fluorine-18-deoxyglucose were performed in a patient with malignant glioma over a one-year period. Postoperatively and during radiation therapy, there was slight improvement in metabolic activity in the hemisphere ipsilateral to the tumor. After radiation therapy and during chemotherapy, there was a rapid and then gradual decline in whole brain metabolic rate by 39%. This might have been explained by radiation effect on brain. The tumor area was metabolically similar to the adjacent brain until one year after diagnosis, when an area of abnormal increased activity was noted. Even though CT scans showed minimal evidence of tumour growth, a large glioblastoma multiforme was found at autopsy at the site of the increased activity. Radiation leukoencephalopathy was also observed at autopsy. It is concluded that PET studies may offer new information regarding the metabolic effects of anti-tumor therapy, and may demonstrate regrowth of tumor prior to CT.Nuclear Medicine Communications 08/1987; 8(7):457-68. DOI:10.1097/00006231-198707000-00002 · 1.67 Impact Factor
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ABSTRACT: The (F-18) fluorodeoxyglucose (FDG) technique to measure local cerebral metabolic rate for glucose (LCMRglu) is well accepted and widely used by many institutions around the world. A large number of studies has been carried out in normal volunteers and patients with a variety of CNS disorders. Several investigators have noted that no significant age-related changes in cerebral glucose use occur with normal aging. Some important and interesting findings have been revealed following sensory, motor, visual, and auditory stimulations. Functional imaging with FDG in certain neurologic disorders has dramatically improved our understanding of their underlying pathophysiologic phenomena. Some abnormalities detected on the positron emission tomography (PET) images have no corresponding changes on either x-ray computed tomograms (XCT) or magnetic resonance images (MRI). In patients with Alzheimer's disease, primary sensorimotor, visual, and cerebellar metabolic activity appears relatively preserved. In contrast, parietal, temporal, and to some degree, frontal glucose metabolism is significantly diminished even in the early stages of the disease. Patients with Huntington's disease and those at risk of developing this disorder have a typical pattern of diminished CMRglu in the caudate nuclei and putamen. In patients with stroke, PET images with FDG have demonstrated abnormal findings earlier than either XCT or MRI and with a wider topographic distribution. FDG scans have revealed interictal zones of decreased LCMRglu in approximately 70% of patients with partial epilepsy. The location of the area of hypometabolism corresponds to the site of the epileptic focus as determined by electroencephalography and microscopic examination of the resected tissue. Ictal scans during partial seizures demonstrate areas of hypermetabolism corresponding to the sites of seizure onset and spread. Several investigators have reported relative hypofrontal CMRglu in patients with schizophrenia. In our center, FDG scans from patients with schizophrenia were successfully differentiated from those obtained in normal controls. Finally, our preliminary data (using PET, XCT, and MRI) in patients with CNS disorders indicate that MRI provides excellent delineation of the structural abnormalities. It may prove to be superior to XCT in the evaluation of certain diseases such as cerebral ischemia and infarcts, head injury, tumors, and white matter lesions. Metabolic imaging with FDG provides functional information not obtainable with either MRI or NMR spectroscopy. Therefore, PET studies will play a complementary role to the anatomic imaging in the management of patients with CNS disorders.Seminars in Nuclear Medicine 02/1986; 16(1):2-34. DOI:10.1016/S0001-2998(86)80002-2 · 3.34 Impact Factor
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ABSTRACT: Nineteen adults with brain tumors have been studied with positron emission tomography utilizing FDG. Fourteen had biopsy proven cerebral malignant glioma, one each had meningioma, hemangiopericytoma, primitive neuroectodermal tumor (PNET), two had unbiopsied lesions, and one patient had an area of biopsy proven radiation necrosis. Three different patterns of glucose metabolism are observed: marked increase in metabolism at the site of the known tumor in (10 high grade gliomas and the PNET), lower than normal metabolism at the tumor (in 1 grade II glioma, 3 grade III gliomas, 2 unbiopsied low density nonenhancing lesions, and the meningioma), no abnormality (1 enhancing glioma, the hemangiopericytoma and the radiation necrosis.) The metabolic rate of the tumor or the surrounding brain did not appear to be correlated with the history of previous irradiation or chemotherapy. Decreased metabolism was frequently observed in the rest of the affected hemisphere and in the contralateral cerebellum. Tumors of high grade or with enhancing CT characteristics were more likely to show increased metabolism. Among the patients with proven gliomas, survival after PETT scan tended to be longer for those with low metabolic activity tumors than for those with highly active tumors. The authors conclude that PETT may help to predict the malignant potential of tumors, and may add useful clinical information to the CT scan.04/1985
Top Journals
University of Pennsylvania
Filadelfia, Pennsylvania, United States
- • Division of Hematology/Oncology
- • Department of Neurology
Hospital of the University of Pennsylvania
Filadelfia, Pennsylvania, United States
- • Division of Hematology/Oncology
- • Department of Radiology


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Armored Core V PlayStation 3
- Publisher: Namco Bandai Games America
- Release Date: Mar 20, 2012
- Also On: Xbox 360
- Critic Score
- Most active
- Publication
- Most clicked
Pelit (Finland)May 11, 2012Armored Core V depicts fast-paced mech-warfare, where mech-building skills and tactical manoeuvres are as important as quick reflexes. [May 2012]
Mar 22, 2012It's still the hardcore spectacle we know and love, with its Moonlight laser blades and hidden AC parts, but by bringing mecha enthusiasts together in a team-based environment that isn't restricted to one-on-one arena battles, we finally have a game on which an online community can be built.
Mar 27, 2012If you can't play online, Armored Core V is rather dry, but if you can, it's a detailed and substantial mech experience made loads better by the addition of other people.
Mar 22, 2012This is fanservice for mecha fans in its purest form. Armored core lovers will definitely appreciate the extensive multiplayer and the usual amazing customization options, everyone else will probably give up soon, due to the boring and repetitive campaign and gigantic amount of data that needs to be absorbed.
Official PlayStation Magazine BeneluxApr 2, 2012This is war in its most brutal form and as fans on the series know this translates into a merciless game with a complex control scheme, complicated menus and a shitload of different parts for your mechs. [April 2012, p.98]
Hyper MagazineMay 14, 2012Despite failing to reach its spectacular potential due to the region issues, there's still a great giant robot sim to be enjoyed. [June 2012, p.65]
Apr 30, 2012Yes, for newcomers, Armored Core V is a difficult game, frustratingly difficult. Yet it can be rewarding to those willing to put their precious hours not into learning a new language, or a skill, but to master a mech-combat videogame.
Apr 5, 2012The technical issues, obtuse game design, and low population really hurt Armored Core.
Mar 22, 2012Armored Core V is a good step forward for this franchise. The huge and interesting multiplayer experience is a nice addition to the Armored Core brand. The lack of balance on the unlocking process and Conquest Mode, sadly, ruins the game's flow.
Mar 22, 2012The most rewarding and commendable component of ACV is its multiplayer offering. If you can get into that, especially with some friends, it's easier to forgive the flaws and have fun.
Mar 21, 2012It's still not the game that will make giant robot sims mainstream, but it does have some innovative ideas in terms of both combat and online play.
Apr 2, 2012Armored Core V has got a huge potential, but fails to deliver because of its unfriendly UI, repetitive missions and online shortcomings.
Apr 2, 2012The true value of the game comes from playing it as a multiplayer experience. Attempting to play through the game as a single, offline player is an uphill struggle during the more difficult missions, and diminishes much of the value found here. But while the multiplayer component provides an interesting platform for interacting with other like-minded mech enthusiasts it only works to mask the otherwise competent core experience beneath it.
Apr 2, 2012Don't get me wrong, the game is fun and a filled online match is second to none. With some better decisions this game could have been special, instead it's forgettable and will likely be abandoned. Sitting in lobbies is not the definition of a good time.
Mar 20, 2012I appreciate the interesting format AC V employs, and enjoyed the sense of camaraderie I had for my team. However, the story missions are too confusing and difficult, the order missions are too short and repetitive, and there is no in-between.
Games Master UKApr 27, 2012Weak combat and shoddy visuals saved by some excellent mech customisation. [June 2012, p.88]
Mar 21, 2012Overcoming the initial intimidation of the vast arrays of stats and finding your footing in the battlefield are certainly challenges worth celebrating when victorious. However, if you're looking for an engaging campaign, measured and concise tactics, and stunning graphics beyond the mechs, From Software's latest entry will leave you severely disappointed.
Apr 18, 2012The game system of Armored Core 5 remains efficient but clearly suffers from out-of-date graphics that only huge fans of the IP will forgive. You've been warned!
Play UKApr 17, 2012Yes, we are annoyed it isn't better than it is. [Issue#217, p.76]
Playstation: The Official Magazine (US)Apr 3, 2012Despite the mechas' new,smaller stature(roughly two-thirds the size of those in previous titles), battles felt sluggish. [May 2012, p.81]
Mar 30, 2012Your typical niche game for those who dig robot combats. The robots are fully customizable, and of course, you can play online... it's deep and rich, even though its production values are clearly less than impressive. The solo campaign is weak, it's really online that its appeal appears.
Mar 21, 2012Armored Core V can field some fierce firefights, but the combat is encumbered by repetitious missions, simplistic objectives, and dull visual design.
Mar 30, 2012Armored Core V is a very dull vision of a future filled with powerful mechs – even though the tactical options and the extensive construction of those metal beasts are quite impressive.
PSM3 Magazine UKMay 16, 2012Fans will love V's hardcore complexities and online battles. It's all poorly presented, and impenetrable for newcomers. [June 2012, p.109]
Playstation Official Magazine AustraliaMay 7, 2012Essentially, the most entertainment here comes from (finally) tweaking your 'AC' to a preferred fighting style, applying tactics to infiltrate enemy lines and using the rocket boots to skate about and scale buildings. Frustration creeps right back in again when you realise how counterintuitive the menus are. [May 2012, p77]
Mar 20, 2012It's not entirely awful. Scaling buildings with your previously mentioned rocket feet gives proceedings an enjoyable verticality. Smashing houses, tanks and 'copters is also empowering like breaking fine china with a giant smashy mallet. But with the most annoying AI this side of Johnny 5 and one-note combat, ACV is repetitive robot rubbish.
Awards & Rankings
User Score
Mixed or average reviews- based on 46 Ratings
User score distribution:
Positive: 12 out of 19
Mixed: 6 out of 19
Negative: 1 out of 19
Mar 21, 2012Armored Core, coming from a person who used to play Chromehounds, another mech game, is different. But coming from From Software just likeArmored Core, coming from a person who used to play Chromehounds, another mech game, is different. But coming from From Software just like Chromehounds did i can definitely see the similarities that come from both series, and i can tell that this is just as good of a game. The only problem i seen was that there was a few glitches on day 1 but they have already been solved in the same day, and the online play is phenomenal, if you are used to a slower mech game like me you will have to take some time to practice and get used to this because if you don't you will be overwhelmed with the real players going wild with the dodging of shots. However, if you are just a single player gamer then i wouldn't recommend it just because its a mainly online game, but that never stopped these horrible titles like call of duty from getting good reviews. This game is really good if you are a mech game fan, and of course the review sites give it low scores because its not horrible like the FPS market is flooded with these day.s… Full Review »
Apr 5, 2012The Best Armored Core game so far. Those who love the mech action genre is gonna love this game. Front Mission Evolved should have been thisThe Best Armored Core game so far. Those who love the mech action genre is gonna love this game. Front Mission Evolved should have been this game. If only Squeenix chose From Software instead of crappy Developers... Anyway, this game plays so much like the old school AC games, which is great. Gone are the flying dual rifles, missile spamming days of AC4/FA. Now, you need to think tactically to flank your adversaries. Great Team online play and customizations options. -- Veteran of AC games since AC: Project Phantasma.… Full Review »
Mar 30, 2012very enjoyable game i wish they made this a while ago looking forward to see how teams will work out. a little lacking on parts but still hasvery enjoyable game i wish they made this a while ago looking forward to see how teams will work out. a little lacking on parts but still has a good selection.… Full Review »

subset: commoncrawl


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It's officially game day. #BeatUK #BearcatNation pic.twitter.com/aLfq8ib5CA
I still have 0 respect for UC students who cheer for OSU.
"@_katherinewebb: What a game. Proud of Bama no matter what #RTR"
You went to auburn....
It's 8:47 and #XavierStillSucks
Today is all about hating OSU and loving all ducks.
Octavius earned a lot of respect from me today. Dude wanted it. Can't wait to take on the world next season. #BearcatNation
Gameday #BeatOSU
Was a fun ride. Hell of a time being a part of my favorite team since I was a kid. Forever #BearcatNation
"Be Uncommon" wear zebra pants. @gunnerkiel @sensitivegunner pic.twitter.com/Q8Rm5u3fd1
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Cleveland went Cleveland and pulled a Cleveland
How the fuck did we manage that one?! I don't care. We won. #BearcatNation
People get buried in nice clothes so I think the zombie apocalypse would be a pretty formal event. #ThoughtsWhenIWakeUp
Going to the stadium. Let's get it. #BeatOSU
Quadri is the village idiot. I'd rather play 5 on 4 than have him out there.
Here comes the entitled ignorance
@theannafaith http://vine.co/v/OWxBJdxaaJV this always puts a smile on my face.
Former QB for the University of Cincinnati. Current Pitt football volunteer Proverbs 3:5-6 #BearcatNation #NYG #NYY #Duke #FlickNation #RIPChamoda
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ArcelorMittal SA mill to shutComment on this story
Johannesburg - ArcelorMittal South Africa Ltd. will shut the steelmaking operations at Africa's biggest steel plant for three months after a fire, a labor union official said.
The shuttering of the operations at the Vanderbijlpark plant south of Johannesburg won't lead to layoffs of workers as they will be redeployed, Deon Reyneke, head of metal and engineering at labor union Solidarity, said in an e-mailed response to queries after meeting with the company.
The company, which is based in Vanderbijlpark, declared force majeure after the February 9 blaze, saying that it can't meet obligations to customers.
"I can't talk about a shut down. An assessment of the plant still has to be concluded. That assessment is underway. I can't indicate when it will be completed," Julian Gwillim, a spokesman for the company said.
"The majority of the plant is still working."
The company's shares fell 1.2 percent to 31.77 rand as of 1:14 p.m. in Johannesburg. - Bloomberg
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Ruth's 1938 Dodgers road uniform purchased at auction for $310,500
Updated: November 15, 2008, 7:38 PM ETAssociated Press
MISSION VIEJO, Calif. -- SCP Auctions bought a full Babe Ruth 1938 Brooklyn Dodgers road uniform for $310,500 at auction at the Louisville Slugger Museum.
SCP Auctions said Saturday that the uniform, the last professional uniform worn by Ruth, was purchased on behalf of a client who is an avid collector of Ruth memorabilia.
Ruth was a first-base coach for the Dodgers during the 1938 season, his final season in baseball. He also regularly took batting practice with the team to appease ...
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