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Given its context, the Ball State' s 31-0 pasting of the Toledo Rockets hardly seemed that important - how big of a deal could beating a 1-4 team be. But after looking at today's AP poll, you can see why the Cardinals' win was so important: as the MUNCIE STAR PRESS notes, by staying undefeated, they were able to crack the Top 25 for the first time ever with a No. 25 ranking.
That news should make Ball State's famous alumni happy, including David Letterman and…um, David Letterman. Actually, that's not true: there are several other notable Cardinal alums, including Janet from Three's Company and Jim Davis, creator of Garfield. News of the Cardinals' cracking the Top 25 probably made him so giddy, that maybe we'll see Jon Arbuckle talking to himself while wearing a Ball State sweater this week.
While the Cardinals don't have a signature win, they do have victories over Indiana and Navy in their belts. But don't hold your breath to see Ball State in a BCS bowl game any time soon: the Sagarin ratings have the Cardinals' strength of schedule at No. 109, so it would take complete chaos for Ball State to have a chance - the college football equivalent of the money market meltdown.
But enjoy the ride while it lasts, Cardinals fans. And for the rest of us, expect to hear quite a bit about Ball State over the next few weeks: the combined records of their next three opponents is 7-15.
In other poll news: Missouri was able to use its thrashing of Nebraska to move past LSU into the No. 2 spot in the Coaches' Poll, while Vanderbilt had the biggest gain, moving up to No. 13 after edging Auburn.


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OROVILLE – The Okanogan County Public Utility District has been having a series of public meetings to explain why it will soon be asking for its first raise in electrical rates in nearly ten years.
About Gary DeVonGary DeVon is the managing editor of the Okanogan Valley Gazette-Tribune and celebrated his 25th year at the newspaper in August 2012. He graduated from Gonzaga University with a degree in Communications - Print Journalism, with an emphasis in photojournalism. He is a proud alumnus of Oroville High School. His family first settled in Okanogan County in the late 1800s. His parents are Judy DeVon and the late Larry DeVon and he has two younger brothers - Dante and Michael. Many family members still call Oroville home. He is single with a grown daughter, Segornae Douglas and a young granddaughter, Erin.
Stories by Gary DeVon
PUD proposing phased in rate hike
Kites will fly high at Bud Clark Ball Fields
OROVILLE – One of Oroville's newest traditions, Kite Day, will take place at Bud Clark Ball Fields on Saturday, April 10 from 10 a.m. to noon.
Oroville School Board hears about district finances
OROVILLE – Shay Shaw, the district's business manager, briefly discussed future finances with the Oroville School Board at their Monday, March 29 meeting.
"We had the cost savings in place last year and we are grateful our levy passed," said Shaw, "but we still do not know which plan the state will chose for school funding next year.
Oroville's Julie Schildgen named 'Teacher of the Year'
OROVILLE – Julie Schildgen, a teacher at Oroville Elementary, has been chosen as the Upper Okanogan Valley Teacher of the Year by the Wal-Mart Corporation.
Veterans Memorial Park will be transferred to Oroville
OROVILLE – After once approving the transfer of Osoyoos Lake Veterans Memorial State Park to Oroville and rescinding their decision, the state Parks and Recreation Commission has again agreed the city would be the best stewards of the facility.
Foul trouble and flu proved too much for Lady Hornets
WENATCHEE – After losing to Liberty Bell on Monday, Oroville's girls' basketball team had one more chance to continue post-season play towards State with a battle against Kittitas in Wenatchee Thursday, Feb. 25.
Oroville will sponsor rural library funding application
OROVILLE – The Oroville City Council gave the nod to the Friends of the Library to pursue federal funding to help build a new public library, a goal the group has been working on for the past several years.
Oroville man survives Coast Guard helicopter crash
ELIZABETH CITY, NC – Darren Hicks from Oroville was one of five crewmen aboard a Coast Guard MH-60T Jayhawk rescue helicopter that crashed in the Uinta Mountains about 50 miles east of Salt Lake City, Utah Wednesday, March 3.
Oroville girls receive big dose of Afgan culture via Skype
OROVILLE – Following months of discussions on the Global Connections and Exchange social networking site, Oroville High School senior Serena Carper organized a Skype call for six girls in her class and more than 15 girls in Jalalabad in Afghanistan.
Tonasket is a 'pedestrian zone'
TONASKET – The Tonasket City Council continued their discussion on the fact that the city is a pedestrian zone, meaning there is no jaywalking within town, during their meeting on Tuesday, Feb. 23.

subset: commoncrawl


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Advanced search
1054th meeting – 15-16 April 2009
Item 4.3
Steering Committee for Human Rights (CDDH) –
Guaranteeing the long-term effectiveness of the control system of the European Convention on Human Rights
i. CDDH's final opinion on putting into practice certain procedures envisaged to increase the Court's case-processing capacity
ii. Activity report "Guaranteeing the long-term effectiveness of the control system of the European Convention on Human Rights"
iii. Opinion of the CAHDI (transmitted to the CDDH) on the public international law aspects of the advisability and modalities of inviting the European Court of Human Rights to put into practice certain procedures which are already envisaged to increase the Court's case-processing capacity, in particular the new single judge and committee procedures
(CM(2009)51 add prov, CM(2009)56 add, DD(2009)156, CM(2009)58)
The Deputies decided to transmit the draft Protocol No. 14 bis to the European Convention on Human Rights, as it appears in document CM(2009)58, to the Parliamentary Assembly, on the understanding that the draft is still under consideration and could be changed by the Committee of Ministers, and invited the Assembly to give its opinion on the draft Protocol, during the forthcoming part-session in April 2009, under the urgent procedure in the Assembly.


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No shares were sold by him. I have done some background research on him before. I have the impression this is what he does. He builds up a company to be sustainable, and then moves on to build another new start up company.


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Yaw Acheampong could be sacked over Ashantigold failure
Ashantigold Chief Executive Kudjoe Fianoo has hinted head coach Yaw Acheampong could be sacked if he is unable to reverse their hot and cold performances in the top-flight.
The miners were shell-shocked by Aduana Stars after going down 1-0 at home in their last Premier League encounter on November 11.
The Obuasi-based club have also been hit with injuries to key players including defensive duo Prince Anokye and Lawrence Lartey.
But the club's Chief Executive says management won't tolerate any excuses from the trainer and his backroom staff.
"We cannot continue to be playing second fiddle in the League. If we want to win, then we must pick some valuable points," Fianoo said
"We held a with technical team and informed them that if it continues like this, we'll be left with no choice but to make heads roll.
"Indeed heads will roll if this on and off performance continues."
Ashantigold travel to the Golden City Park in Berekum to face Berekum Arsenals on Sunday.
Ansong says:November 22, 2012 05:29 pmThe same thing will happen to unqualified kumasi coach if he fails to perform @ AFCON.wise up*


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Is it possible to change the speed of Premiere's playback of the video without altering the speed of the produced version? Even if I could play it only 1.5x faster, it would mean a lot of time saved in the long run.
Yes - while playing the video, press the
For further options, please reference the relevant Premiere Pro documentation.


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- 87Promote
Framed Art Print
Half Fullby Alicia Bock
Choose from a variety of frame styles, colors and sizes to compliment your favorite Society6 gallery, or fine art print - made ready to hang. Fine-crafted from solid woods, premium shatterproof acrylic protects the face of the art print, while an acid free dust cover on the back provides a custom finish. All framed art prints include wall hanging hardware.
Fine art Polaroid by Alicia Bock.
I've always loved this photograph.
wonderful! ...great title too!
Beautiful work!
Thank you all so very much!
What a wonderful way to portray a newly unfurled fern.....
love the green/aqua color combo!
Thank you Tracey and Joy!
Love the title as well as the image.
Thank you so much Joan!
Beautiful simplicity.
lovely ♥
very beautiful, instant fave!
Thank you all so very much!
I love this!
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4 posts tagged with Disney and movie.
Displaying 1 through 4 of 4. Subscribe:
What a strange movie...
Weird movie memory filter: I feel like it was a Disney Channel movie. The premise was a 14ish year old girl wanting to be in a boy's band, so she ended up dressing like a boy and they let her in the band. She was also in an all girl band and it happened that they had to perform on the same day. Chaos ensues, and she is found out in the end... Any help is great.
You Lucky Dog
Help! Where can I find a copy of the Disney Channel original movie You Lucky Dog (wiki/imdb)? I've looked everywhere and can't find anything. [more inside]
Disney movie about telepathic twins?
MovieFilter: When I was a kid (late 90's) there was a movie on the Disney Channel or Family Channel that I absolutely loved. Help me find out what it's called! [more inside]
Disney channel movie
Movie on Disney channel in late 80s early 90s. Involves boy with crush on girl who turns out to have magical skills, she lives by a lake in cottage with her ?grandmother? who is a witch. Perhaps in England? Anyone? I picture the girl as having long dark, slightly wild hair.
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Lou Iacovino
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Adaptive Martial Arts Empowers Those with Disabilities
Here is an example of something near and dear to my heart, martial arts. Applied to modern day positive growth the Willow Foundation for Adaptive Martial Arts teaches a self-defense class at the Abington YMCA for people with disabilities. Kenn Perry, black belt, who contracted polio at age 3, leads the class. In an age where many martial arts are fueled by aggression and ego, here is an organization that aims towards personal growth, development and actualization. Bravo Adaptive Martial Arts!


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covering over 29,324 products. See what the press says about ReviewGist here.
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The health system in Bulgaria has undergone significant transformations since the transition and it continues to evolve. It highlights some positive developments, particularly in the area of public health, but continues to find gaps that recent reforms have been unable to reverse.
This report presents the findings of a study aiming to define the least cost short and medium term measures that the Government of Bulgaria can implement to meet gas security of supply requirements.


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Saturday, November 24, 2012
I have 5 tattoos. I got the first when I was 22, the last probably 10 years ago. Not everyone regrets their tattoos, but I do. I feel like I'm not the same person I was when I got them and I just want them gone.
I don't have problems with tattoos in general. Whatever makes you happy! But mine don't make me happy anymore. So I'm having them removed.
I started looking into it a few years ago but it was really expensive and I've watched videos of people screaming and crying while they're getting theirs taken off. Wasn't looking forward to either of those things!
Well, I found a clinic that does them for less than half of the best prices I could find in Dallas and it's only about 7 miles from my house. I set up an appointment and budgeted out in my head that I could afford to get 3 treated at a time.
You can only get a tattoo treated with a laser every 4 weeks, more often than that causes scaring. And it usually takes 3-5 treatments to remove each tattoo, depending on the colors and the type of ink used. It also depends on things like your own body's healing properties. You can't tell before hand how many sessions... it's a wait and see kind of thing.
I went for my appointment and the lady who runs the clinic told me that she'd do all 5 of mine at the same time for the price I'd budgeted out, basically she was doing 2 of them for free! Bonus!
So I'm laying on the table and she tells me that she will stop at any time if the pain is too much, I just need to let her know. I started to sweat at that point, honestly! But then she goes to work and... I kept waiting for this super-intense pain... that never came. Yes, it hurt, but it wasn't bad at all. Not as bad as it hurt to get some of them. It only took a couple of minutes to treat each of them so it was over really quick. I never had to ask her to stop, in fact we carried on a conversation the whole time she was treating me.
So, in a few months I will be tattoo free. Another step in my transformation. YAY!!!!!
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Yeah Nancy! I agree with Angela.... you have the new you to celebrate. Out with the old and in with the new !!!
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I'm so happy for you! I've always worried about young people getting tattoos. I had my first at 43 years old, a mother and baby dolphin on my foot in memory of our son. Then I had my eyeliner done but I don't think that should count. I had another small (light pink) one last week on my inner wrist to remind me of my life's journey. At 51, I am a totally different person than I was in my young 20's. (Scary to think of what I would have gotten back then! LOL)
I am so proud of you and your transformation. It's even better that it's almost pain-free and less expensive than you anticipated. Good things come to good people!
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It's Wonderful how we change over time, isn't it Nancy? Oh the beauty of living life and becoming the very best of ourselves!
Congratulations on the transformation and so glad there was minor pain...
love ya!
Comment edited on: 12/3/2012 10:29:06 AM
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Yeah Nancy! I am so glad you are transforming yourself into your ideal. You are letting go of the past in a variety of ways.
Love, hugs and Squishes!
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Republican U.S. Rep. Geoff Davis of Kentucky resigned Tuesday, citing a family health issue.
Davis had previously announced he would retire this year from Congress. He said in a statement issued Tuesday that a family health issue had developed recently that needs more of his time.
âAs a result, I cannot continue to effectively fulfill my obligations to both my office and my family,â he said. âFamily must and will come first.â
Davis, 53, is a fiscal and social conservative and has been in the House since 2005. His 4th District stretches along the upper tier of Kentucky from the Louisville suburbs to the West Virginia border.
âI have served with great men and women in the Congress in both parties, and leave knowing that the House is filled with people who love this country and are working to make our future better,â Davis said. âI am grateful to have been blessed by being a part of this great institution.â
The statement said Davis submitted his resignation to Gov. Steve Beshear and House Speaker John Boehner.
Lynn Sowards Zellen, spokeswoman for the Kentucky secretary of stateâs office, said the U.S. Constitution requires that a special election be held to determine who will fill the seat.
Republican Thomas Massie and Democrat Bill Adkins are running to succeed Davis in Novemberâs general election. The GOP holds both U.S. Senate seats in Kentucky and three of the stateâs five other House seats.
âMy wife, Rhonda, and I admire Congressman Davisâ familyâs commitment to God, family and country and pray for a swift and complete recovery from their family health issue,â Massie said in a statement.
In a telephone interview Tuesday night, Adkins said it would be âunfortunateâ to have a special election so close to the regular election and said he wished Davis and his family well.
âI hope nothing is wrong,â Adkins said.
U.S. Senate Minority Leader Mitch McConnell of Kentucky commended Davisâ years in office.
âHe has accomplished much and has worked tirelessly on behalf of the people of Kentucky during his tenure,â McConnell said in a statement. âI wish him and his family well as he embarks on his new endeavor.â
Davisâ statement doesnât specify the nature of the health issue. Davis first talked in June to 4th District GOP chairman Kevin Sell about resigning before the end of the year, Sell said. Sell said Davis at the time assured him that he and his family will be fine. He said he doesnât know the details of the health issue Davis referred to.
âIt has been a very personal decision for him, between him and his wife, Pat, and his children,â Sell said.
The Cincinnati Enquirer contributed to this story.
Source: Courier-Journal


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Comment Re:Ouch? (Score 1) 301
I think the real blame lies y'know, with the people who actually used this as a vehicle to cheat on their spouses. Blaming this leak for the fallout is like blaming your spouse's friend who rats you out for cheating on them.
This statement is like saying "Yeah, I know revenge porn is bad, but the real blame lies y'know, with the girl who sent nude pictures in the first place. It was only a matter of time before someone re-published it"
Three things need to be remembered before you support this hack because the cheaters deserved it:
1. Ashley Madison was its self a scam. People who used the site were already being punished. Shutting down the site is actually GOOD for cheaters, because they will now know to turn to a more legitimate dating site in future.
2. Just because someone signed up to the site doesn't mean they were actually going to cheat on their spouse. It's like a list of people who've ever walked into a brothel. When push comes to shove, many people think better of their bad decisions on their own - not everybody who walks into a brothel ends up sleeping with a hooker.
2. Collateral damage - It's not just the individual listed in the leak who suffers.
2a) Plenty of public figures (doctors, lawyers, teachers, politicians) are women. They will now have to deal with their reputation that they're married to a "cheater", because public opinion doesn't understand point 1. (Imagine how a high school teacher is going to feel when some kid puts his hand up in class and says "Is your husband xxxxx? I just found his details on the Ashley Madison data dump. Do you let him spank you?")
2b) When parents divorce, their children go through hell. If cheating can dealt with privately, forgiven by the victim and the cheater changes his ways, that's a better outcome for the whole family than the alternative. Thanks to this hack, there is no longer an option for victims of cheating to deal with their husband's bad behaviour privately. This increases the chances of a worse outcome for the children.
Now, before you mod me down for my opening statement, I do understand there is a MASSIVE difference between revenge porn and this hack; but both have come about because of a breach of trust from the counterparty.
I do think it's reasonable to compare the feelings experienced by the people listed in this data dump with those experienced by women who find themselves on a revenge porn site. That is online bullying plain and simple. It is easy, and emotionally satisfying to blame the people who signed up and were silly enough to use their real name, but it is extremely unhelpful, and the whole "two wrongs might make a right" argument doesn't hold much water when you counter in the fact that Ashley Madison was ALREADY taking cheaters for everything they were worth.
However, it is an important lesson that needs to be re-iterated to Internet users daily: Information wants to be free. Access controls are temporary, content is permanent. Once you have posted something online (or sent something via MMS) you have no control over what happens to it. It cannot be deleted, It cannot be revoked, One of two things happens to online information: It will either rot into obscurity, or become public. You have no privacy online. That horse has bolted.
The responsibility rests with you: Accept the reality that privacy online is nothing more than an illusion and protect yourself by treating everything you post, publish or send as PUBLIC.


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Reviewed by Old Peculiar on 14 April 2015
Taken over by Marstons and reopened as a 'Generous George'. Place always seems packed as I drive past.
Reviewed by Gill Smith on 14 December 2014
Called in this 2015 Good Beer Pub and enjoyed an excellently served Batham's Bitter. Popular with the locals, but was welcoming to our group. Cobs available.
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Ashwood Inn, The (Bells Lane, DY8 5DQ)
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Red Lion (147 Brettell Lane, DY8 4BA)
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Rose & Crown, The (High Street, DY8 5SF)
Samson & Lion (Brierley Hill Road, DY8 5SP)


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Mist of Stagnation is a multiplayer FPS/RTS hybrid that will put you into fast paced, objective based game play, in a Steam Punk world. Two teams will battle for control of the few remaining resources left on the war ridden planet, in order to advance their technology. The core game play will be based on gathering resources in the forms of Control Points, to then be used by a 'Commander System' to build upgrades for their team. Upgrades to weapons, vehicles, and armor to name a few will be the fundamentals for a winning team. Can you survive as the Commander, or work your way up the chain of command and lead your team to victory? Will you fight on the front lines or lead from the rear? Can you make the important decisions that will determine the outcome of the battle, or are you a natural born killer? Throw on some goggles and lace up your boots, salvation lies ahead in the Mist of Stagnation.
This update we will show off some of the newest steampunk creations in 'The Blacksmith', our new control point, and some of the new models.
Posted by *Don* on Feb 23rd, 2013
Over the last couple of months we have been working very hard on getting our first level ready for the alpha. We added on a few new members to help speed up the development. One of the newest members is Michael Ackerman, concept artists. He has done an amazing job at bringing our ideas to life.
To start you off, have a listen to the latest track from our newest composer Nathan Palmer
This is the blacksmith shop in the mining camp. The blacksmith shop is in a choke point near the last control point. It is still a WIP but you can see the general layout. Check out the high res versions for full detail.
Some of the major models were done by a couple new members to our team: Louis Woodhouse, and Taylor Bjorndahl.
Here are some of their contributions:
We have also just redone our control point models.
We have gone thorugh a lot of variations since the game has come about, but we were never happy with it... until now!
Since the story line of the game tells of collecting resources, we decided to give our control points a purpose. That is why we now have two type of control points, each one will be recognizable for the type of resources it is producing.
The light on top will show the owner.
We would also like to announce part one of our summer Game Convention tour where we will be showing off our game and giving the public a chance to play it.
We will be starting off at Screw Attack Gaming (SGC) in Dallas, Tx on June 21-23 at the Hyatt Regency in Downtown Dallas - (Booth 10).
Two weeks later we will be down at Rooster Teeth's very own RTX in Austin, Tx on July 5th to 7th at the Austin Convention Center - (Booth info to come).
We have two more conventions we are going to this year on the West Coast, so look forward to that!
We all thank you for watching our progress, and we are moving along VERY fast these days. We will be starting our Alpha Tester applications in about two weeks, so be sure to follow us on Facebook and on IndieDB/ModDB.
Nice models, nice update


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Home Page
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Luxury Homes for Sale in Butte MT
If you are looking for one of the most beautiful homes in all of Butte MT, you have come to the right page. The Luxury Homes page features the most elaborate, gorgeous, and expensive homes in all of Butte. These homes generally range from $400,000 to $2,000,000. These beautiful homes in Butte are harder to come by than many other kinds of real estate, so if you see one that you like, don't hesitate to buy!
Butte MT Real Estate


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Bleach: The Broken Limit
continuation of Bleach Aizens Rage, with all new updates and more. [More]
Currently Unavailable
Only Windows users can play this game. If you have an emulator, you can join the waiting list to be informed when a new server is ready to play.
Game Owner: Matt(Chillo)
Please support BYOND through Membership or a donation!
Sky Ikamazu: (Nov 20 2011, 9:58 am)
Hey dude I found the host files for the ORIGINAL BLEACH AIZENS RAGE!


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Lil' Tammy Video 4
Lil' Tammy is my homie from San Diego. He's 16 years old and will pretty much school anyone at anything technical. He's got a pretty terrible beard and does some pretty long nose wheelies and I'm sure you don't want to miss this video. Check it out.
4 comments
2130 bman http://p.vitalbmx.com/photos/users/2130/avatar/c50_2130_45956e44de17a.jpg?1293020173 http://www.vitalbmx.com/community/bman,2130/all 12/08/06 1 3 1 1 7 1 45 3
i remeber seeing the san diego jam video, and this kid nosed a driveway to 360 in. still one of THE coolest things ive seen done on a bike. i am so going to learn that one day.
13800 awwshiz /images/default/avatar/c50.png http://www.vitalbmx.com/community/awwshiz,13800/all 01/12/08 1 24
tuck no-hander to manual looks like it shouldn't happen


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FW: NEH Summer Institute on Regional Study/Appalachia
Expand Messages
- fyi..aj wright // ajwright@...
-----Original Message-----
From: H-NET List for Tennessee History and Studies
[mailto:H-TENNESSEE@...]On Behalf Of Mark R. Cheathem
Sent: Thursday, January 08, 2004 1:04 PM
To: H-TENNESSEE@...
Subject: ANN: NEH Summer Institute on Regional Study/Appalachia
Date: Sat, 03 Jan 2004 15:39:01 -0500
From: Peter Crow <pcrow@...>
From June 3-29, Ferrum College in Ferrum, Virginia, will host its second
National Endowment for the Humanities Summer Institute for College and
University Teachers. For four weeks, twenty-five scholars from throughout
the country will discuss ³Regional Study and the Liberal Arts: Appalachia Up
Close,² focusing on scholarly and pedagogical issues related to using
regional material in undergraduate classes.
Among the guest speakers are novelists Lee Smith and Robert Morgan, as well
as scholars Crandall Shifflett, Altina Waller, and Stephen Fisher. Their
observations about the shift to modernization in Appalachia are applicable
to many regions of the nation and world. The institute will spend a week
doing fieldwork with Big Creek People in Action in Caretta, West Virginia.
Scholars from regions outside Appalachia will contribute their own regional
perspectives and apply what they learn of Appalachian issues to their areas.
Faculty in fields such as literature, history, political science, sociology,
religion, philosophy, or the arts are eligible to apply. Successful
candidates receive stipends of $2,800. The institute director is Ferrum
English professor Peter Crow (pcrow@...). APPLICATION DEADLINE:
March 1.
More information as well as application materials are available at
Peter Crow
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Biography > Noteworthy People > Deaths > 2000 Deaths > R - Z
Alfred SchwarzmannAge: 87
German Olympic gymnast; won three gold medals and two bronze at the 1936 Games and won one a silver 16 years later, at age 40, for West Germany at the Helsinki Games; He died after a long illness.Died: Goslar, GER, Mar. 11
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Hey, I'm Xtina!
Greetings from The Urban Oasis SF! I have been living in the beautiful, diverse, cosmopolitan city of San Francisco for over 18 years. I am a proud, California native and have been living in my funky SF flat for over a decade now. I am a lover of arts & culture, in particular, Caribbean music, dance and cuisine. Born and raised on the beautiful island of Puerto Rico, Hector is a gifted musician, teacher and chef. With his original, traditional and popular sound, he leads his own band called La Mixta Criolla, which you can find on itunes. We love meeting and hosting people from all over the world. Since 2010, we have hosted more than 200 guests from more than 20 different countries. We truly appreciate the wonderful opportunity to meet like-minded folks and create amazing connections from all over the globe! In addition to being a superhost, last year I was featured in Airbnb's 'Why Host' Campaign on Airbnb tv, and was recently interviewed on the local news for being one of the city's most active hosts. Ideally, we want to show our guests a great time, break bread, share wonderful conversations to learn about you and where you come from! I take great pride in my home and make every attempt to keep it updated, beautiful and aesthetically pleasing for everyone. From Europe to Asia, South America to Canada, come over and experience "The Urban Oasis SF" for yourselves! We have a warm, friendly, multicultural vibe and environmentally-conscious home awaiting you! So don't wait to book, it's especially popular during high season (March-November). My motto is: "If I can't see the whole world, then at least I can bring the world to me." :) We strive to minimize our impact on this earth as much as humanly possible. PLEASE RECYCLE & REUSE! DON'T BUY THINGS YOU DON'T REALLY NEED. BE CONSCIOUS ABOUT YOUR ENVIRONMENTAL IMPACT and EDUCATE YOURSELF on how you, too can minimize, lessen your carbon footprint and live simpler, happier, healthier and more consciously!!! Madre Tierra THANKS YOU :)


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James Packer, Lachlan Murdoch fall out over new Ten Network chief James Warburton
- From: Herald Sun
- March 02, 2011
of 2
BILLIONAIRE James Packer has walked away from the Ten Network board after falling out with Lachlan Murdoch and fellow directors over a new chief executive.
Mr Packer's shock resignation preceded an announcement from Mr Murdoch, the acting chief executive, revealing the group had poached a key executive from rival media mogul Kerry Stokes.
James Warburton will quit his post as Seven Media Group's advertising sales chief and join Ten as chief executive on July 14.
It is believed Mr Packer argued against Mr Warburton's appointment and quit after failing to sway fellow board members.
Mr Packer's departure comes only three months after he muscled his way on to the board after a series of spectacular share raids that netted him 18 per cent of the company.
He offloaded half to Mr Murdoch and both joined the board, prompting Australia's richest woman, Gina Rinehart, to join in.
Mr Packer and Mr Murdoch -- with regional TV broadcasting baron and fellow board member Bruce Gordon -- were believed to be deeply unhappy with Ten's strategy and executive chairman Nick Falloon was soon shown the door.
Last week, chief executive Grant Blackley was sacked after only two months in the job and Mr Murdoch became interim chief.
Despite his departure, it is believed Mr Packer will retain his 9 per cent stake in the company, at least for the time being.
His resignation also prompted speculation he had quit because of a conflict of interest with Consolidated Media Holdings, in which he has a 45 per cent stake.
Regional pay-TV group Austar yesterday confirmed takeover talks with Foxtel, which is 25 per cent owned by CMH, triggering a 16 per cent surge in Austar's share price.
Austar said the talks had occurred between its majority shareholder Liberty Media and Foxtel, but a deal was not imminent.
Mr Warburton will join Ten after spending most of the past decade helping spearhead Seven Media Group's successful multi-platform and multi-channel advertising strategy.
One media observer said his reputation was formidable and he would be a boon to Ten.
"He's the best in class in the ad sales space," one source said.
BBY analyst Mark McDonnell agreed: "Warburton is the logical appointment to head the channel as somebody who has strong credentials within Australian TV."
Observers believe Ten's biggest problem has been its inability to transfer its ratings share into revenue share. They cannot have a very expensive program that is not rating in their lead program spot.
The network last week revealed its sales were haemorrhaging, and ratings for its hyped long-format news and current affairs were dismal.
Mr Warburton is believed to have presented his rescue strategy to the Ten board before being signed, with the group's flagship station, Channel 10, the first in need of emergency surgery.
"They are losing share to their new digital channel, Eleven, so they are cannibalising their own audience," the source said.
Mr Warburton also will join the Ten board.
His three-year fixed term contract will earn him a base annual salary of $2.2 million, with a 50 per cent bonus.
Ten shares closed 1.13 per cent lower to $1.31.
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Bryan Stevenson of Hunter Posted at 2:35 PM March 02, 2011
Not his father I'm afraid
mick Posted at 2:31 PM March 02, 2011
hopefully they will pack negus back to the nursing home, WHY!!!! cause he is terrible
Tom of Sydney Posted at 2:28 PM March 02, 2011
Don't panic CH7, you still have Kochi and Mel. Not to mention you are the No1 station for tabloid trash. So, your ratings are guaranteed.


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Facebook Responds to Yahoo Patent Lawsuit With Counterclaims
Facebook Inc., operator of the world's biggest social-networking site, accused Yahoo! Inc. of infringing 10 patents through its home page and Flickr photo-sharing service and in ads displayed throughout its site.
Facebook, which was sued by Yahoo for patent infringement last month, made the counterclaims yesterday in a federal court filing in San Francisco. Facebook denied stealing Yahoo's technology, saying its rival's patents are either invalid or its claims legally barred and the lawsuit should be dismissed.
"While we are asserting patent claims of our own, we do so in response to Yahoo's shortsighted decision to attack one of its partners and prioritize litigation over innovation," Ted Ullyot, Facebook's general counsel, said in an e-mail.
Yahoo, owner of the most popular U.S. Internet portal, has been struggling to keep pace with Google Inc. and Facebook, which have lured away users and ad dollars. Facebook filed for an initial public offering in February that may value the business at $75 billion to $100 billion, people familiar with matter have said.
David McCombs, an intellectual property lawyer at Haynes & Boone LLP in Dallas, said the countersuit by Facebook means "the gloves are off, and they will fight it out."
'Picks a Fight'
"If someone picks a fight with you, then you certainly would respond in kind, typically," he said yesterday in a phone interview. "You would expect Facebook to have intellectual property assets that would be applicable to anyone that's operating in that space."
Yahoo, based in Sunnyvale, California, alleged in its lawsuit that Facebook infringes patents covering functions critical to websites, including Internet advertising, information sharing and privacy. It's seeking an order barring Facebook from infringing 10 patents and for triple damages.
The lawsuit followed Yahoo's statements in February that Menlo Park, California-based Facebook, like other Web companies, must license its technology.
"We have only just received Facebook's answer and counterclaims, but on their face we believe they are without merit and nothing more than a cynical attempt to distract from the weakness of its defense," Yahoo said in an e-mailed statement. "We have proposed that Facebook join us in discussions to resolve the matter, but our overtures have been rejected. As a result, we are prepared to continue to seek redress through the courts."
Facebook's Counterclaims
In its counterclaims, Facebook says its patents are infringed directly by Yahoo's home page and Flickr and through advertisements displayed throughout Yahoo's site on finance, sports, games and shopping services.
Facebook patents at issue in the counterclaims include those related to technologies for generating a feed of stories personalized for social network users, posting headlines and distributing user profiles over a network. The company is seeking court orders declaring that it doesn't infringe Yahoo patents, blocking Yahoo from using its patents and awarding it unspecified damages from Yahoo.
Yahoo lost its No. 1 spot to Facebook last year in the U.S. market for display advertising, which includes video and graphically based marketing messages, according to EMarketer Inc. In January, Yahoo reported fourth-quarter revenue of $1.17 billion, excluding sales passed on to partner sites.
Facebook, which has more than 845 million users, is seeking $5 billion in what could be the largest Internet IPO on record. Facebook's implied valued rose 8.9 percent to $102.8 billion March 30 in what was expected to be the last auction of its stock on SharesPost Inc.'s exchange before the IPO.
The case is Yahoo! Inc. v. Facebook, 12-cv-01212, U.S. District Court, Northern District of California (San Jose).


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Three new sessions have been added for the 2014 Abarth Track Experience, the advanced track-day learning opportunity offered to owners of the 2015 FIAT 500 Abarth. Timed to help build awareness of the new, automatically transmissioned Abarth editions, in both coupe and cabriolet body styles, the events will be held at:
- Daytona International Speedway in Daytona Beach, Fla., on September 9 and 10
- Lime Rock Park in Lakeville, Conn., on September 29 and 30
- Auto Club Speedway in Fontana, Calif., on November 11 and 12
Each location will showcase the 2015 Fiat 500 Abarth in four driving modules, allowing participants to enjoy autocross runs and head-to-head challenges while also exploring the car's driving dynamics and sheer performance capabilities—of which there are plenty.
After all, the 2015 Fiat 500 Abarth gets a major power-up compared to the standard model and relies on a turbocharged 1.4-liter, four-cylinder MultiAir engine to unleash 157 hp and 183 ft.-lbs. of torque. Naturally, Abarth also provides a comprehensive uptuning throughout the 500 package to showcase the 500's nimble reflexes and track-friendly suspension, and for the new model year, that includes a high-performance six-speed automatic transmission. Engineers thoroughly reworked the unit to handle the increased output of the 2015 Fiat 500 Abarth, deploying additional clutch plates and improving heat treatment while also developing a specially calibrated Sport mode designed specifically for enthusiasts.
The party line from Jason Stoicevich, head of FIAT Brand North America: "As the Abarth Track Experience becomes more popular, we're expanding the schedule to ensure more customers have the opportunity to develop their driving skills in a safe track environment. Now, with the addition of the specially tuned automatic transmission as an option for the 2015 Fiat 500 Abarth and Abarth Cabrio, we expect even more customers will want to join in the fun."
The 2015 Fiat 500 Abarth is at dealerships now with an MSRP of $22,195, which includes complimentary registration for the Abarth Track Experience. For more info, see, www.AbarthExperience.com.


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Tel.: [+358-9-19125595], Fax: +[358-9-19125105]
Short Report
Somatic mutations and germline sequence variants in patients with familial colorectal cancer
Article first published online: 29 JUN 2010
DOI: 10.1002/ijc.25529
Copyright © 2010 UICC
International Journal of Cancer
Volume 127, Issue 12, pages 2974–2980, 15 December 2010
Additional Information
How to Cite
Gylfe, A. E., Sirkiä, J., Ahlsten, M., Järvinen, H., Mecklin, J.-P., Karhu, A. and Aaltonen, L. A. (2010), Somatic mutations and germline sequence variants in patients with familial colorectal cancer. Int. J. Cancer, 127: 2974–2980. doi: 10.1002/ijc.25529
Publication History
- Issue published online: 29 JUN 2010
- Article first published online: 29 JUN 2010
- Manuscript Accepted: 15 JUN 2010
- Manuscript Received: 11 FEB 2010
Funded by
- Academy of Finland (Finnish Center of Excellence Program 2006–2011)
- The Finnish Cancer Society and the Sigrid Juselius Foundation
- Abstract
- Article
- References
- Cited By
- colorectal cancer;
- familial;
- susceptibility;
- CAN genes;
- germline
It is estimated that up to 35% of colorectal cancers (CRC) can be explained by hereditary factors. However, genes predisposing to highly penetrant CRC syndromes account for only a small fraction of all cases. Thus, most CRCs still remain molecularly unexplained. A recent systematic sequencing study on well-annotated human protein coding genes identified 280 somatically mutated candidate cancer genes (CAN genes) in breast and colorectal cancer. It is estimated that 8% of all reported cancer genes show both somatic and germline mutations. Therefore, the identified CAN genes serve as a distinct set of candidates for being involved in hereditary susceptibility. The aim of this study was to evaluate the role of colorectal CAN genes in familial CRC. Samples from 45 familial CRCs without known cancer predisposing mutations were screened for somatic and germline variants in 15 top-ranked CAN genes. Six of the genes were found to be somatically mutated in our tumor series. We identified 22 nonsynonymous somatic mutations of which the majority was of missense type. In germline, three novel nonsynonymous variants were identified in the following genes: CSMD3, EPHB6 and C10orf137, and none of the variants were present in 890 population-matched healthy controls. It is possible that the identified germline variants modulate predisposition to CRC. Functional validation and larger sample sets, however, will be required to clarify the role of the identified germline variants in CRC susceptibility.
Colorectal cancer (CRC) is the third most common cancer with around 50,000 estimated deaths in the United Stated in 2009.1 Current studies estimate that up to 35% of CRCs involve inherited susceptibility.2 However, germline mutations in genes of high penetrance, such as APC in FAP and MLH1 in HNPCC, are believed to explain only a subset of hereditary CRCs.3 Thus, the genetic etiology of many familial cases remains unexplained. It has been hypothesized that much of the remaining inherited genetic risk is a consequence of common low- and rare moderate-penetrance variants. Candidate gene sequencing approaches are well suitable for detecting moderate-penetrance genes that methods such as linkage analysis and genome-wide association (GWA)-based strategies cannot spot. Further efforts to identify additional susceptibility genes are well justified to reduce morbidity and mortality caused by CRC.
The first genome-wide effort to identify genes mutated in cancer was carried out by Sjöblom et al.4 in a study where more than 13,000 genes in 11 breast and 11 colorectal cancers were analyzed. In the first screen, a total of 1,307 somatic mutations in 1,149 genes were identified. With a statistical method that took into account variations in mutation frequency, context and nucleotide type affected, a set of candidate cancer genes (CAN genes) was attained. The identified CAN genes, 189 in total, were described as true driver genes with mutation frequency higher than expected by chance alone. A more complete picture of the cancer genome was presented by Wood et al.5 in a follow-up study of the previous effort, including the analysis of around 18,000 protein-coding genes. Rank ordered lists of 280 CAN genes, equally spread between breast and colorectal cancer, were obtained.
Today, as many as 418 cancer genes have been identified and of these 8% show both somatic and germline mutations (www.sanger.ac.uk/genetics/CGP/Census/). On the Human Cancer Gene Census website, 15 somatically mutated CRC genes are listed, and germline mutations have been reported in 6 of them (www.sanger.ac.uk/genetics/CGP/Census/).6 This indicates that the somatically mutated CAN genes serve as a distinct set of candidate genes for being involved in hereditary susceptibility. The aim of this study was to evaluate the role of colorectal CAN genes in familial CRC. The mutational profiles of the 15 top-ranked CAN genes were analyzed for somatic and germline variants in a series of 45 familial CRC patients.4, 5
Material and Methods
Study subjects
The CRC samples and corresponding normal tissues used in this study were selected from a population-based set of 1,042 samples. These were prospectively collected at nine Finnish central hospitals between years 1994 and 1998. This study was approved by the Helsinki University Hospital Ethics Committee. Complete clinical data, including age at disease onset, family history, pathology reports, tumor grade and stage, are described in more detail in previous works.7, 8 After extensive analyses, 40 of these 1,042 samples have been identified as carriers of known CRC susceptibility genes, whereas 113 familial cases have remained mutation negative. In this study, the focus is on mutation negative familial cases, with typically one additional CRC case in first-degree relatives. From these, 45 tumor samples previously evaluated by a pathologist were selected. They all displayed >70% carcinoma tissue, were of grades I–III and of microsatellite stable status. Respective normal samples were available from all cases. The average age at diagnosis was 71.9 years (SD, ±11 years; median age, 73 years), and 13% of the patients had more than one diagnosed CRC case in a first-degree relative. DNA from paraffin-embedded tissues was derived for selected first-degree relatives. Blood DNA samples from population-matched healthy individuals, obtained from the Finnish Red Cross Blood Transfusion Service, were used as controls.
Candidate gene selection
A recent large-scale sequencing effort identified 140 possible colorectal CAN genes.5 In our study, 15 top-ranked CAN genes were selected and analyzed for mutational profile (Table 1). We excluded the following CAN genes: APC, TP53, SMAD4 and PTEN, which were known CRC predisposing genes. KRAS has been extensively studied in familial CRC and was also left out from our analysis. All coding exons and adjacent splice sites were covered related to the Reference Sequences with the longest coding region (NCBI database, Build 36.1, released March 2006).
Sequencing methods
Primers were designed using the ExonPrimer program (http://ihg2.helmholtz-muenchen.de/ihg/ExonPrimer.html). Primers for amplifying DNA extracted from paraffin-embedded tissue were designed with the Primer3 program (http://frodo. wi.mit.edu/primer3/). Primer sequences and PCR conditions are available on request. The fragments were amplified using AmpliTaqGold® enzyme (Applied Biosystems, Foster City, CA). PCR products were purified enzymatically with ExoSAP-IT PCR purification kit (USB Corporation, Cleveland, OH). Direct sequencing was done by using Big Dye Terminator kit 3.1 (Applied Biosystems, Foster City, CA) and ABI3730 Automatic DNA Sequencer (Applied Biosystems, Foster City, CA). All methods were performed according to manufacturers' instructions.
Sequencing strategy
The initial sample panel consisted of 45 familial colorectal tumor samples. All variants observed and not found in SNP databases were confirmed by reamplifying and sequencing the tumor DNA. The respective normal samples were screened to distinguish between somatic and germline origin. A panel of control samples from anonymous Finnish blood donors was examined to exclude polymorphisms. A total of 480 control samples were selected according to patients' place of birth. If data from the first 45 patients was compatible with possible identification of a novel hereditary predisposing gene, the analysis was further extended to 61 familial CRC normal tissue DNA samples. The extended panel consisted of both microsatellite unstable (28) and microsatellite stable (33) cancer patients. Finally, all sequence graphs were examined both manually and by computer analysis (SoftGenetics, State College, PA). All reference sequences were obtained from the NCBI database (NCBI database, Build 36.1, released March 2006).
Genotyping of 967 CRC cases and 410 healthy controls for CSMD3 c.4045 T>G, EPHB6 c.961 G>C and c10orf137 c.872 T>C was carried out by using iPLEX Gold chemistry (Sequenom, San Diego, CA). The genotyping of SNP markers was performed by the Institute for Molecular Medicine Finland FIMM Technology Centre, University of Helsinki. Detailed protocols and primer sequences are available on request. The average genotyping success rate was 99.7%.
RNA extraction
Total cellular RNA was extracted using the RNeasy kit (Qiagen, Valenica, CA) and used for cDNA synthesis by reverse transcription PCR according to standard protocol (Promega Corporation, Madison, WI).
In silico analysis
Two sequence homology-based tools were used to predict the potential impact of the identified nonsynonymous germline variants on protein function: Sort Intolerant from Tolerant (SIFT; http://blocks.fhcrc.org/sift/SIFT.html) and Polymorphism Phenotype (PolyPhen; http://www.bork.embl-heidelberg.de/PolyPhen/). If the SIFT prediction tolerance index score was ≤0.05, the variation was considered deleterious. Predictions made by PolyPhen were assigned as "probably damaging," "possibly damaging" or "benign." The potential splicing effect of the germline variants were predicted by two splice site prediction programs: NetGene2 (http://www.cbs.dtu.dk/services/NetGene2) and the Berkeley Drosophila Genome Project (BDGP, http://www.fruitfly.org/seq_ tools/splice.html).
Samples from 45 familial CRCs without known cancer predisposing mutations were screened for somatic and germline variants in 15 CAN genes. In total, 356 exons were sequenced with a mean coverage of 90%. Tumors were first screened, and all variants observed that were not found in SNP databases (www.ensembl.org, http://hapmap.ncbi.nlm.nih.gov/) were sequenced in respective normal tissue of the individual. Altogether, 22 nonsynonymous somatic mutations and 16 germline variants were identified (Table 2). Each variant occurred only once in the sample panel.
The somatic mutations included 20 missense, 1 nonsense (FBXW7, R367X) and 1 splice-site mutation (TCF7L2, IVS10+1 G>A). The effect of the splice site mutation was analyzed by cDNA sequencing, which revealed abnormal mRNA splicing leading predominantly to skipping of Exon 10. Notably, these changes were not observed in matched normal tissue, hence demonstrating their somatic origin. Seven of the somatic mutations were novel variants not found in the COSMIC database (www.sanger.ac.uk/genetics/CGP/cosmic/, Table 2). The most frequently mutated genes were phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) and F-box/WD repeat-containing protein 7 (FBXW7, also known as CDC4), with eight mutations in each. Location of the mutations in PIK3CA and FBXW7 was nonrandom. Most of the mutations occurred in known mutational hotspots in the domain regions of the proteins (Table 2).9, 10
Of the 16 identified germline variants, 11 were missense and 5 were silent changes. Silent germline variants were not studied further. The identified missense germline variants were screened in population-matched controls. The following three missense germline variants could not be found in a set of 480 population-matched healthy individuals (average success rate 94%): (i) Erythroid differentiation-related factor 1 (C10orf137) I291T, (ii) CUB and sushi domain-containing protein 3 precursor (CSMD3) F1349V and (iii) Ephrin type-B receptor 6 precursor (EPHB6) A321P (Table 2). In addition, the three germline variants were succefully genotyped in 410 population-matched healthy controls with negative results. To evaluate the contribution of the germline variants in our population-based material,7, 8 967 CRC cases were genotyped. No additional variations were identified.
None of the tumor samples showed loss of the wild-type allele and each of these variants was detected only once in our sample set. In two of these families, one CRC case in first-degree relatives had been diagnosed in addition to the index (Fig. 1). One family had two diagnosed CRC cases in addition to the index. Also, other cancers had been identified in these families. The germline variant I291T in C10orf137 was also observed in the affect child, diagnosed with CRC at age 45 years. EPHB6 A321P was not present in the affected brother. Finally, the genes showing the highest somatic mutation frequencies, PIK3CA and FBXW7, were screened for their entire coding region in additional 61 normal tissue CRC samples. However, no germline variants were identified.
Two in silico prediction programs, SIFT and Polyphen (http://blocks.fhcrc.org/sift/SIFT.html, www.bork.embl-heidelberg.de/PolyPhen/), were used to estimate the potential impact of the germline variants on protein function. Only EPHB6 A321P was predicted to have a deleterious effect on protein function when considering results from both programs. In addition, none of the germline variants were predicted to have a splicing effect, as tested in silico by NetGene2 and BDGP programs (http://www.cbs.dtu.dk/services/NetGene2, http://www.fruitfly.org/seq_tools/splice.html).
A recent systematic sequencing study on breast and colorectal cancer, including the great majority of human genes, identified 280 somatically mutated CAN genes. These included well-known cancer genes but most had not previously been linked to cancer.5 Because 8% of the genes mutated in cancer show both somatic and germline mutations, we hypothesized that the identified somatically mutated CAN genes may be involved in hereditary predisposition.4, 5 We, therefore examined the mutational profile of 15 CAN genes in a panel of 45 familial CRC cases without known CRC predisposing mutations.
Altogether, we identified 22 nonsynonymous somatic mutations of which the majority were of missense type. To our knowledge, seven of the somatic mutations have not been previously linked to cancer (Table 2). The top-ranked CAN gene PIK3CA was one of the most highly mutated genes with eight somatic missense mutations. PIK3CA encodes the p110 catalytic subunit of the class IA phosphatidylinositol 3-kinases (PI3Ks). Oncogenic PI3Ks are known to play a key role in CRC tumorigenesis. The somatic mutation frequencies of PIK3CA have been reported as 14–32% and 9% for sporadic and familial CRC, respectively.9, 11, 12 In this study, all somatic mutations affected residues in the helical and kinase domains of the protein, with most mutations falling into previously reported mutational hotspots E542, E545 and H1047. These hotspot mutations have been shown to elevate lipid kinase activity, highlighting the oncogenic nature of these alterations.13, 14
The mutational profiling of FBXW7 resulted in identification of eight somatic mutations. FBXW7 is a component of an ubiquitin ligase complex that targets molecules, including cyclin E and MYC, for degradation.15, 16 Numerous cancer-associated somatic FBXW7 mutations have been reported, and the gene is described to have a tumor-suppressive role in the development of cancer.17 Recent studies have shown that mutations of a single allele at FBXW7 can have dominant-negative effects in addition to the more common loss of function. The mutation data presented here is highly similar to that previously described, with mostly heterozygous missense mutations affecting conserved arginine residues in the protein interaction domain.18 Because these mutations affect residues at the protein interaction domain, a potential consequence is disruption of substrate binding. We also identified a heterozygous somatic nonsense mutation (R367X) located downstream of the dimerization domain. This somatic mutation has been previously identified, once in CRC and once in endometrial cancer, further strengthening its potential involvement in tumorigenesis.19, 20 Hypothetically, this nonsense mutation that results in a truncating protein might not be able to bind substrates but might interfere with wild-type FBXW7 protein through dimerization.
A somatic splice-site mutation was identified in TCF7L2 that caused skipping of Exon 10. Also, Wood et al.5 identified two somatic mutations in the IVS10 donor of the TCF7L2 gene. TCF7L2 is an important Wnt signalling pathway component and regulates the proliferative cellular compartment in the intestine.21TCF7L2 has shown to be mutated in CRC with frequent somatic frameshift mutations increasing the activity of the protein in microsatellite-unstable CRCs.22 Several TCF7L2 isoforms have been described with cell type-specific distribution and in differential gene-regulatory responses.23 The splice mutation reported here could potentially favour tumor growth; however, functional assays are required to clarify the role of the aberrantly spliced form in CRC development.
Altogether, three novel germline variants were identified, C10orf137 I291T, CSMD3 F1349V and EPHB6 A321P, which were not present in SNP databases or in a set of 890 population-matched healthy controls. EPHB6 A321P was shown not to segregate with CRC in the family, speaking against, but not excluding, a possible role of this variant in CRC predisposition. C10orf137 I291T segregated with the disease phenotype, providing evidence for pathogenicity. Specimens to evaluate segregation of the CSMD3 variant were not available. All three identified missense variants were located at predicted domains (Table 2). When analyzed in silico, EPHB6 A321P was predicted to have a damaging effect on protein function. EPHB6 belongs to the Eph receptor tyrosine kinase family and lacks kinase activity. Several studies have suggested that EPHB6 may act as a tumor suppressor gene.24 Currently, the function of C10orf137, CSMD3 and EPHB6 has not been completely defined, and additional studies will be required to further clarify their role in cancer in general.
In conclusion, our data on somatic mutations in CAN genes is in good agreement with previous works in general.4, 5 However, the majority of the analyzed genes did not show any mutations. These further highlight the idea previously presented that tumors are heterogeneous with very few mutations in common. Nevertheless, different genes contributing to cancer are often functionally equivalent, acting through the same molecular pathway. It appears that pathways rather than individual genes control the tumorigenic process.5, 25 To our knowledge, no germline variants have previously been indentified in CSMD3, EPHB6 and C10orf137 in patients with CRC. All of these variants were present at a low frequency (1/45) in our sample set. It is, however, possible that they modulate predisposition to CRC, although the low frequency of these variants suggests a limited role in hereditary susceptibility. Functional validation and larger sample sets will be required to clarify the role of the identified germline variants in CRC susceptibility.
We thank Ms. Sini Marttinen, Ms. Sirpa Soisalo, Ms. Eevi Kaasinen, Ms. Mairi Kuris, Ms. Inga-Lill Svedberg, Ms. Iina Vuoristo, Ms. Maarit Ohranen and Ms. Maarit Lappalainen for technical assistance. This work was supported by grants from Academy of Finland (Finnish Center of Excellence Program 2006–2011), the Finnish Cancer Society and the Sigrid Juselius Foundation and by grants to A.E.G. (The Chancellor of the University of Helsinki, Finska Läkarsällskapet).
- 1Cancer Statistics, 2009. CA Cancer J Clin 2009; 59: 225–49., , , , , .
- 2Environmental and heritable factors in the causation of cancer—analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 2000; 343: 78–85., , , , , , , , .
- 3Explaining the familial colorectal cancer risk associated with mismatch repair (MMR)-deficient and MMR-stable tumors. Clin Cancer Res 2007; 13: 356–61., , , , .
- 4The consensus coding sequences of human breast and colorectal cancers. Science 2006; 314: 268–74., , , , , , , , , , , , et al.
- 5The genomic landscapes of human breast and colorectal cancers. Science 2007; 318: 1108–13., , , , , , , , , , , , et al.
- 6A census of human cancer genes. Nat Rev Cancer 2004; 4: 177–83., , , , , , , .
- 7Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. N Engl J Med 1998; 338: 1481–7., , , , , , , , , , , .
- 8Population-based molecular detection of hereditary nonpolyposis colorectal cancer. J Clin Oncol 2000; 18: 2193–200., , , , , , , , , , , , et al.
- 9High frequency of mutations of the PIK3CA gene in human cancers. Science 2004; 304: 554., , , , , , , , , , , , et al.
- 10FBXW7/hCDC4 is a general tumor suppressor in human cancer. Cancer Res 2007; 67: 9006–12., , , , , , , , , , , , et al.
- 11The prevalence of PIK3CA mutations in gastric and colon cancer. Eur J Cancer 2005; 41: 1649–54., , , , , , , , , , .
- 12Patterns of PIK3CA alterations in familial colorectal and endometrial carcinoma. Int J Cancer 2007; 121: 915–20., , , , , , .
- 13Functional analysis of PIK3CA gene mutations in human colorectal cancer. Cancer Res 2005; 65: 4562–7., , , , , , , , , , , , et al.
- 14Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. Proc Natl Acad Sci U S A 2005; 102: 802–7., , .
- 15Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science 2001; 294: 173–7., , , , , , .
- 16Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J 2004; 23: 2116–25., , , , , , , , , .
- 17Inactivation of hCDC4 can cause chromosomal instability. Nature 2004; 428: 77–81., , , , , , .
- 18FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat Rev Cancer 2008; 8: 83–93., .
- 19CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability. Cancer Res 2005; 65: 11361–6., , , , , , , , , , .
- 20hCDC4 gene mutations in endometrial cancer. Cancer Res 2002; 62: 4535–9., , , , , , , , .
- 21TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling. Biol Chem 2002; 383: 255–61., , , .
- 22Frequent alterations in the Wnt signaling pathway in colorectal cancer with microsatellite instability. Genes Chromosomes Cancer 2002; 33: 73–81., , , , , , .
- 23The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines. Cancer Res 2000; 60: 3872–9., , , , , .
- 24EphB6 receptor significantly alters invasiveness and other phenotypic characteristics of human breast carcinoma cells. Oncogene 2009; 28: 1706–13., .
- 25Mutational profiling of cancer candidate genes in glioblastoma, melanoma and pancreatic carcinoma reveals a snapshot of their genomic landscapes. Hum Mutat 2009; 30: E451–9., , , , , , .


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Neil Shapiro
Revolving Door (0)
Sightings (4)
RPA Goes Back to Basics for Honda - Posted October 15, 2014
Yesterday we posted on an RPA campaign in which the agency dove into comedic short films for client Honda with the help of funny man Nick Thune. In today's offering, RPA does things a bit more traditionally for the same client. Here's "Music Festival": ... [MediaJobsDaily]
Your Undead Post, Part II: Hyundai Builds Zombie-Killing Machine in 'Chop Shop' - Posted October 14, 2013
"If you want to survive, listen up." So begins Innocean's new spot "Speech" for Hyundai (Two undead posts in a day? What the hell, it's October). The speaker of those lines credits his ability to live off the land and fight for his survival, but an onlooker points to his Hyundai zombie-killing... [GalleyCat]
72andSunny Waxes Nostalgic in New Spots for Samsung Galaxy Gear - Posted October 7, 2013
72andSunny pays homage to sci-fi and television history in their new campaign for Samsung Galaxy Gear. The spot "Evolution" traces the evolution of wristwatch communication, from Dick Tracy and Star Trek to Inspector Gadget and even Predator. The spot ends with the text "After All These Years It's Finally Real" before introducing... [GalleyCat]
The Isaiah Mustafa Blitz Continues - Posted March 7, 2011
... [GalleyCat]


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The Client List Sets Season 2 Premiere Date
Jennifer Love Hewitt in 'The Client List' -- Lifetime
The wait for the return of "The Client List" is almost over.
The Lifetime drama, starring Jennifer Love Hewitt, returns for Seaosn 2 on March 10 at 10 PM ET/PT, the network announced on Thursday.
PLAY IT NOW: Jennifer Love Hewitt: 'It Would Be Really Fun' To Be Anastasia Steel
"The Client List" ended with a big cliffhanger - Jennifer's Riley character, was at The Rub, holding the book that contains the actual "list" (of male clients, who use The Rub ladies for sexual services) as the police showed up.
Also, Riley's estranged husband, Kyle (Brian Hallisay), had recently returned to town just as she started to develop things on a romantic level with her brother-in-law, Evan (Colin Egglesfield).
VIEW THE PHOTOS: Celebrity Brunettes
-- Jolie Lash
Copyright 2013 by NBC Universal, Inc. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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9/11 - 10 years later
- Solemn reflection, unshaken resolve
- The Wife
Online Extras:
9/11 Report
Read the complete 9/11 Commission Report.
The Money Trail Map
The Denver Post made a first-ever attempt to account for the $354 million in U.S. Homeland Security Department grants Colorado governments have spent since Sept. 11, 2001.
9/11 Photo Wall
Share your thoughts and memories about the events of Sept. 11, 2001 and the decade since.
Colorado's Fallen
Photos and information about the men and women who gave their lives over the last decade.
OTIS — The dog's name is Merlyn, like the wizard.
But as he hobbles across a field on Ann Wichmann's farm one recent afternoon, it's clear his days of enchantment are growing few. His eyes and mouth are rimmed in powder white, his breaths labored.
And then, as he pauses briefly, his back legs give beneath him, leaving the black Labrador who could once climb ladders struggling to stand. Wichmann, who raised Merlyn from birth and trained him to be one of the nation's elite search-and-rescue dogs, kneels beside him.
She cradles him in the grass.
"Merlyn," she said earlier, "won't make it another year."
Ten years ago, Merlyn was just 2 years old when Wichmann took him to New York as part of a local Federal Emergency Management Agency rescue team that searched the rubble of ground zero. By day, Wichmann took her dog Jenner out on the pile for an operation that had shifted to recovery as they arrived — a grim mission to learn how many bodies were buried there.
By night, Merlyn ventured out with Wichmann's friend Matt Claussen and did the same.
Ground zero was a new experience altogether for Wichmann and her dogs — one of smoldering debris and hanging girders and jagged glass — but the success of dogs in handling the difficult conditions has opened more roles for search canines and their handlers in emergency operations. Dogs are now standard on FEMA teams.
And Wichmann, who retired from FEMA work earlier this year, hopes to expand their use even more. In 2005, she moved to her farm — named for Jenner — where she not only trains her own dogs but also leads small-group seminars for novice handlers.
"The dogs are still the very best detection tool there is," she says. "The key is getting them there quickly enough for them to make a difference."
But even in the best circumstances, searches often end sadly.
Wichmann never learned the names of the victims Jenner and Merlyn uncovered at ground zero. But she knows that the discoveries of their remains allowed their families to move on with their lives, even as the experience left something behind in Wichmann's life.
Every Sept. 11, she thinks about those victims. She looks up to the sky, watches as the light fades and the stars brighten. She thinks of an American Indian legend: The Milky Way is the "Pathway of Souls."
The people she found at ground zero are there, she thinks. Jenner, who died in 2004, is too.
And Merlyn will be joining them soon.
But when it is time, a life of searching has taught Wichmann that it will not be goodbye. No one is ever truly lost. You just have to know where to look.
"I'm lucky enough out here," Wichmann says. "I can see the Pathway of Souls."
John Ingold, The Denver Post


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Picture: Tom Cruise filming on the set of 'Oblivion' at the foot of the Empire State Building New York, City, USA - 13.06.12
Tom Cruise's comedy musical 'Rock of Ages', also featuring Catherine Zeta-Jones and Russell Brand, was heavily tipped to top the box-office following its release this past weekend. In the end, it was animated adventure 'Madagascar 3' that hung on to the top spot, though perhaps more worrying for Sony Pictures - 'Rock of Ages' didn't even finish runner-up.
It was Ridley Scott's sci-fi epic 'Prometheus' that clung onto the No.2 spot, in a repeat of last week's box-office results. Even more surprisingly, Adam Sandler's comedy caper 'That's My Boy' finished all the way back in fifth - one of the actor's worst results for years. With the likes of 'Mamma Mia', 'Chicago' and 'Hairspray' all performing strongly at the box-office in recent times, it begs the question, why didn't 'Rock of Ages' go down as well with musical fans? Well, critics were less than impressed with the movie, with Claudia Puig of Usa Today writing, "Don't stop believing. Just avoid cliched musicals that try to capture the anarchic spirit of rock with trite commercial re-treads". Richard Corliss of Time Magazine also stuck the boot in, saying, "So willfully bad that not even Cruise's valiant Cpr can help", while Peter Bradshaw of the UK's Guardian newspaper wrote, "Doubtless, like The Producers, it will be adapted back into the theatre, some time in 2017, at which time it will be even more bland and tiring".
In all fairness, 'Rock of Ages' is likely to be a mere blip on Tom Cruise's recent movie credits, which includes the huge grossing 'Mission Impossible 4' (with a fifth instalment on the way). He recently completed filming the crime-drama 'Jack Reacher', and also has plans to star in a sequel to his 1986 movie 'Top Gun'.


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All Stories
Clayton Schools hosts county social studies fair
Clayton County students tackled a wide range of social studies topics this year -- from how Adolf Hitler caused the holocaust, to the mysteries of Stonehenge, to whether the world will end with the conclusion of the Mayan calendar in 2012.
Investigation continues in cable theft case
The attorney for a McDonough man charged with buying and selling stolen cable equipment insists his client is innocent.
Development conference focuses on south side
Some of the leaders of Clayton, Henry, Fayette, Spalding, Coweta, Douglas and south Fulton counties will convene next week to discuss the topic of moving the south-metro area forward, during the 2010 South Metro Development Conference.
Educators to protest state funding cuts
Members of Georgia Association of Educators chapters from across the state, and their supporters, are expected to converge on the state Capitol building this afternoon, to tell lawmakers that enough is enough with funding cuts to education.
Road work planned for key Henry intersection
Henry County officials have broken ground on planned highway improvements for Ga. Highway 81 at Keys Ferry Road. The $1.3 million project is designed to alleviate traffic tie-ups, during rush-hour commuting times.
Teen shot, killed, another injured in Riverdale
An 18-year-old girl was shot in the head and killed, Thursday, while she was driving a car on Creekstone Way in Riverdale, according to Clayton County Police.
Henry hospital offering CPR course
Registration is under way, at Henry Medical Center, for a CPR course geared toward health-care workers.
Clayton BOE to weigh budget options, redistricting
Clayton County Public Schools Superintendent Edmond Heatley will update the county's school board about options for reducing spending in fiscal year 2011, when the board meets on Monday, Jan. 25.
Henry gets land, home for arts
Henry County artists may soon have a new venue in which to display their crafts.
Clayton Kia dealership delivers Cathy's 'special-order'
Representatives of the Kia Atlanta South Dealership, in Morrow, were present in Atlanta Friday, when Kia Motors America announced the first retail sale of a 2011 Sorento, built at the Kia plant in West Point, Ga.
Luella can't handle pressure in OT
DeAndre Stroud caught a pass at the top of the key with seconds ticking away needing to find an open look to the basket to break a tie game. He looked, hoping to penetrate to the basket, but instead found three Stephenson defenders encircled him, forcing him to take a deep and rushed 3-point shot that missed.
Ola reserve comes up big in win over Stockbridge
With the game on the line, Ola coach Curt Miller didn't have reservations in letting a reserve player take two big free throw shots.
Lady Panthers hold off upset-minded Jonesboro
The fist time No. 10-ranked Forest Park played Jonesboro this year, the Lady Panthers crushed the Lady Cardinals 76-57.
Henry suitcase drive sets local record
For its location, the Stockbridge office of Georgia Cancer Specialists collected a record number of bags and suitcases during the eighth annual Totes 2 Tots Suitcase Drive for Foster Children.
Bless the Lord, oh my soul ... - Jim Bell
We should all bless the Lord Jesus for all He has done for us. We should thank Him every day for His birth, His life, His teachings, His miracles and, certainly, for His sacrificial death on the cross.
Why we need the Bible, now more than ever - Todd Dionne
There can be no doubt about it, the Bible is the most influential book in the history of the world. It is also the most widely read book in history.
Country store a fixture in McDonough community
The small convenience store sits at the bottom of a hill in rural Henry County.
Attorney General Baker to speak in Morrow
State Attorney General Thurbert Baker, who is making a run for the Governor's office this year, will take questions from the public on Monday at the Morrow Municipal Complex Community Room.
Gordon adding degree programs in mathematics, biology
Gordon College officials hope to fulfill a growing need in the area's educational sector through the college's two, new, four-year, degree programs.
Clayton students' 'voices' heard at annual competition
Roberta T. Smith Elementary School second-grader, Jayme Fielder, looked like a one-person United Nations by the time she finished talking about the different nationalities in her family tree, during a competition at the Clayton County Public Schools Performing Arts Center on Thursday.
Forest Park girls ranked 10th in AP Class AAAA prep poll
A year ago, Forest Park girls basketball coach Steve Cole was patrolling the sidelines as head coach of the boys team.
Teacher faces termination for fight with student
A Clayton County Public Schools employment tribunal is recommending that Brian Galloway, a physical education teacher at Riverdale High School, be fired for fighting back against a student who attacked him last month.
White gets a second chance at Signing Day
Last February, on National Signing Day, Union Grove sat down seven of its football players at a long, rectangular table. They wore clean slacks, a crisp dress shirt with a tie and the baseball hat of the college that offered them the chance to continue playing football. Cameras flashed and parents stood near with beaming countenance.
Local teen charged with vehicular homicide
A Riverdale teenager has been charged with vehicular homicide, in connection with an automobile crash in which his passenger was ejected from the vehicle, and later died from his injuries.
Buckner honors locals for public service
In Clayton County, the good deeds of many individuals sometimes go unnoticed.
Region 4-AAAA race about to get interesting
A few weeks ago, Stockbridge was sitting comfortably atop the Region 4-AAAA standing.
National commander to visit local American Legion
The national commander of the American Legion will visit Clayton County American Legion Post 258 in Jonesboro on Saturday, according to Post Commander John Harper.
DeKalb district attorney to conduct Turner probe
Georgia Attorney General Thurbert Baker said DeKalb County District Attorney Gwen Keyes Fleming has been named as the special prosecutor in the investigation of former Clayton County Police Chief Jeff Turner.


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Celestron NexStar 4 SE Telescope
Grounded in ease of use, it lets you reach for the stars
Does the NexStar telescope allow you to boldly go where you've never gone before?
Over the years, as telescopes have become more advanced, many models have also become much more complicated to use. When Celestron's NexStar SE family of telescopes was introduced a few years back, they were designed to put the focus on the ease of use and the fun of astronomy by offering many of the advanced viewing features commonly found on more expensive telescopes but offering a more intuitive user interface.
The NexStar 4 SE is a 4-inch Maksutov-Cassegrain telescope and is the smallest in Celestron's NexStar line up. Combining the classic look of the orange tube telescope with state-of-the-art features, such as a fully computerized operating system, flash upgradeable hand control, and superior StarBright XLT coatings, the NexStar 4SE telescope is designed to give users a high-performance telescope that can turn a dark backyard into a deep-space observatory for the entire family.
Computerized Mount
Probably the biggest feature of the NexStar is the computerized mount. The mount allows the telescope to automatically point itself at any visible object with the push of a button. The NexStar 4 SE telescope utilizes Celestron's innovative technology to help automatically align the telescope for optimum viewing of stars, planets or galaxies that are selected by the user from a computer database menu of over thousands of celestial objects. Upon locating each celestial object, the NexStar SE telescopes will display interesting historical and scientific facts about the star, planet or galaxy being viewed via the LCD screen located on the telescope's backlit handheld control unit.
The hand-controlled computerized mount allows the telescope to automatically point itself at any visible object with the push of a button.
Easy Set Up Right Out of the Box
The telescope comes nicely packed, and there is not much assembly required. The NexStar 4 SE includes a sturdy adjustable tripod, a motorized alt-azimuth mount, and the NexStar hand-held computer controller. Basically you just need to secure the mount/telescope on the tripod and then attach the finderscope and eyepiece on the telescope. On the telescope there is a star pointer finderscope, a 53X eyepiece, flip mirror control, and a focusing knob. The steel tripod and alt-azimuth mount provide a solid base for the NexStar 4 SE. A small level is also included to make sure the telescope sits on level ground. Overall, I found the telescope to be very portable and I was able to easily fold it up and load into my car to take to a field at a local school for better viewing conditions.
Computer Controller Set Up
The hand-held computer controller is used for accessing many of the telescope's features. With the hand control you can select the planets, stars, and other objects you want to see as well as change the speed that the telescope moves. It's powered by 8 AA batteries and I suggest you purchase rechargeable NiMH batteries or an optional power adapter if you plan on using it in your backyard.
Before you can begin using the telescope, you must set up the computerized hand controller and go through the SkyAlign alignment procedure. In order for the NexStar to accurately point to the objects in the sky, it must be first aligned with known positions (stars) in the sky. With this information, the telescope can create a model of the sky, which it uses to locate any object in its database. The SkyAlign setup procedure can be little tricky and it took a while to get it programmed properly.
The next thing you need to do is align the finderscope and telescope. The easiest way to align them is to point the telescope at the moon or another easily findable object like Polaris, and then adjust the finderscope and a red dot will appear in the center of that object. Once you have set up the finderscope you are ready to begin your celestial journey.
NexStar SE telescopes come equipped with computerized Sky Tours, that provide a hands-off tour of the night sky using a customized list of the "best objects" available for viewing according to time and location. Here, the author is Checking out all the night's sky has to offer.
Watcher of the Skies
The Nexstar 4SE's SkyAlign feature points you in the right direction. You only need to point it to three bright objects in the sky. I found one of the easiest ways to align it to the night sky was using the Solar System Align feature. If you don't want to choose and point it at three bright objects, you can choose the moon. The moon is very easy to spot on most any clear night. Simply point the telescope's finderscope to it, the red dot appears, and the magic begins.
Once the telescope is properly aligned, viewing stars and other objects is easy. You can either control the telescope manually by using the arrows on the hand control, or pick an object on the hand control and have the telescope go there automatically.
The Bright Side of the Moon
It was a stroke of good luck that the moon was in the full phase during one of my viewings and I able to easily see many of its intimate details, such as the famous crater Tycho. After a few minutes, I found both Saturn and Venus after using the moon as the alignment object. Unfortunately, they appeared just as white dots. Just near Saturn I found the bright star Spica in the constellation of Virgo that lit up the June night's sky. The standard equipment 25mm E-Lux plossl eyepiece gives a magnification of 53X, enough to see many stars and some planets. You also can purchase optional eyepieces to zoom in for more detail. The NexStar 4 SE is smallest in the series. It is ideal for someone just dipping their foot in the star gazing pool. If you are a little more advanced and are expecting to see more details and color in the planets and stars you probably want to buy a higher-powered telescope in the NexStar line.
The NexStar SE telescope includes a version of SkyX First Light Edition astronomy software for exploring the universe on any PC and printing out custom star charts of the sky, in addition, NexRemote software allows users to operate the telescope from their PC. The NexStar has a computer interface and will connect to your computer with a RS-232 cable. The big problem here is that an RS-232 port is a thing of the past. You will need to purchase a USB adapter to hook up the RE-232 cable to your laptop. I would strongly suggest that Celestron make the change to a USB port on future models.
Astrophotography Option
The NexStar 4 SE also has the ability to mount your DSLR this lets you take pictures of your favorite objects in the sky. To use this mount you will need to purchase on optional T-Adapter and a T-Ring that matches your DSLR camera's lens opening. There is an included cable that can plug into the telescope and camera and take the pictures for you.
A good telescope can literally open your eyes to a universe of celestial delights. The Celestron NexStar 4 SE offers good optics and computerized "GoTo" tracking in a package that's lightweight and transportable at a little over 20 pounds. It is an ideal telescope for a beginner, its four-inch optics produce clear and sharp images and is well worth the money at an under $500 price point. But you'll need to purchase additional accessories needed for taking photos of the night sky and connecting the telescope with your laptop. This sturdy and portable Celestron scope is ideal for astronomy enthusiasts committed to spending less time searching for celestial objects and more time looking at them.
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My Nonprofit Reviews
Genna W.
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Review for Givology, Philadelphia, PA, USA
I've always wanted to give back in some way to an international cause. When I found Givology on Idealist.org and learned more about its mission to help children globally achieve better access to an education, I was hooked. I've also been so honored to work with an amazing team of dedicated volunteers, and it's great to be able to use my professional skills to help benefit the organization.
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Connect With Us800-299-9470
The Lewis Queen Upholstered Headboard with Button Tufting Tan Collection creates a charming focal point in your master suite with the simple elegance of this queen headboard. Featuring button-tufted detailing, This Lewis Queen Upholstered Headboard is available in either Tan leather or a soft tan microfiber fabric. Lewis Queen Upholstered Headboard also pair with the matching storage bench for harmonious bedroom look.
The Lewis Queen Upholstered Headboard with Button Tufting will bring the finishing touches to your master suite. Featuring a group of upholstered headboards and benches, accentuate your bedroom with casual elegance. These pieces are available in either a Tan leather or a soft tan microfiber to accommodate your personal style and home decor.
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Oklahoma City University's Student Publications staff is responsible for the production and publishing of:
- the university's student newspaper, The Campus, and
- the university's student media website, MediaOCU
Mission Statement
The purpose of Oklahoma City University's Student Publications is to inform, entertain and serve the OCU community. The community includes the university's student body, faculty, staff, trustees, alumni, and administrators.
Although Student Publications serve a broad community, the publications' primary focus is Oklahoma City University's student body. Student publications not only inform, entertain and serve the students, but also serve as the students' printed voices. This is done while maintaining the university's focus on a liberal arts education rooted in the United Methodist tradition of servant leadership.
The publications fulfill the above missions through accurate, ethical and objective reporting of campus- and community-related events. Coverage is facilitated by members of a student editorial board and overseen by a faculty adviser.
While fulfilling the above missions, the publications provide students with realistic, hands-on journalistic training by offering jobs including those related to reporting, production, design, sales, and management to students in any major.


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Written on: 30/06/2005 by PurpleMonkeyDishWasher (1 review written)
Good Points
It is light, easy to use.
Bad Points
Does not work well with oter brands of tapes and battery
General Comments
Panasonic NV-DS60 - Overall its is a good little camera.
As rated by our community of reviewers
" This product is ultra-light, compact and stylish with superb video ... " Read More
Written by dmartin
" Do Not Under Rate This Small DVR " Read More
" Good but not perfect, which is a shame " Read More
Written by eddiemarsden
" Best Buy for the Price I found " Read More
Written by SaifulHasan1
" Great second hand buy! Highly reccommended. " Read More
Written by johnnyboy86


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Ruaidri Ó Conchobair
From Wikipedia, the free encyclopedia
|This article does not cite any references (sources). (December 2009)
Ruaidri mac Cathal Ua Conchobair was King of Connacht in Ireland.
|Preceded by
Aedh mac Eoghan Ua Conchobair
|King of Connacht
1309 - 1310
|Succeeded by
Felim mac Aedh Ua Conchobair
- Annals of Ulster at [1] at University College Cork
- Annals of the Four Masters at [2] at University College Cork
- Chronicum Scotorum at [3] at University College Cork
- Byrne, Francis John (2001), Irish Kings and High-Kings, Dublin: Four Courts Press, ISBN 978-1-85182-196-9
- Gaelic and Gaelised Ireland, Kenneth Nicols, 1972.
- The Second Battle of Athenry, Adrian James Martyn, East Galway News & Views, 2008–2009
|This biography of a member of an Irish royal house is a stub. You can help Wikipedia by expanding it.


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Pet adoption story: Sadie, Sydney and Cessna
Pets: Sadie and Sydney
Owner: Kathy Darnell
Pet: Cessna
Owners: Heather and Abhi Bhakta
Sadie and Sydney's story: In the spring of 2004, Kathy adopted Sadie and her companion Sam from Tennessee Valley Golden Retriever Rescue where they had been surrendered due to the health of their owner. Sadly, in the summer of 2008, Sam passed away from cancer and Sadie became depressed over the loss. Over the next several months, Sadie was introduced to puppies with the aim of finding a new companion. She met a six-month-old Sheltie-mix from Young-Williams Animal Center who had been surrendered because she had grown too large. The two of them hit it off immediately, but there was one small issue: the Sheltie-mix had been named Sadie by her previous owner. In deference to Sadie the golden retriever, Sadie the Sheltie-mix had her name changed to Sydney and they have been great buddies ever since. Sadie will turn 15 this year while Sydney will be 6.
Cessna's story: Cessna is a 12-year-old golden retriever mix that was adopted from Tennessee Valley Golden Retriever Rescue in the summer of 2002 when she was 1 ½ years old. Not much is known about her past except she had just had a litter of puppies. Our daughter was 1 ½ years old at the time of the adoption so we decided that she should share her birthday with our daughter. Cessna was the most patient dog anyone could ask for when our daughter and son were younger, and is now a great companion for them.
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