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Spirit of Sicily Trip Notes
Spirit of Sicily
Last Modified: 02 Sep 2015
Spirit of Sicily
Trip code: ZGKS
Validity: 01 Jan 2015 to 31 Dec 2015
Ancient civilisations, prehistoric caves, Byzantine churches, Baroque buildings and majestic landscape – the island of Sicily has it all. Immerse yourself in all the glory of Sicily including its mouth-watering cuisine!
This trip is run by our experienced sister company Peregrine Adventures. Your group is therefore likely to be a mixture of Intrepid passengers and other like-minded international travellers.
Table of Contents
- 'Comfort travel' means encountering all that the real world has to offer, but with an added degree of, well… comfort. We use more private transport, the travel pace more relaxed, the accommodation a touch nicer. And by paying a little more up front, you'll be treated to more included meals, more leader-led activities and get a greater immersion in all things local.
Walking & Trekking
Day 1 Palermo
Our journey starts in the bustling city of Palermo, the capital of Sicily. Palermo can easily be reached by boat, train or plane. While at your discretion, we recommend arriving and departing by train where possible within Europe, because this method of transports minimises carbon emissions. There are no activities planned today, so you may arrive at any time. Please make your own way to the joining hotel (details are in your travel documents). In the evening, we meet our tour leader and our fellow travelling companions at a Welcome Meeting (this is usually at 6pm, but you will be advised of the exact time and place in a notice located near the reception at our hotel). At the meeting, our tour leader will give us a briefing on what lies ahead on our tour. Afterwards, we dine together in a local restaurant.
Hotel Joli or similar (1 nt)
Day 2 Monreale/Palermo
This morning we take a stroll through the old heart of Palermo, admiring some of its main monuments such as the cathedral, which has a wonderful mix of styles. Originally built in the 12th century, it has been modified a number of times, most notably in the 18th century with the addition of its dome. We also spend some time wandering through some of the city's colourful markets. Our private minibus then transfers us to nearby Monreale, situated in a panoramic position above Palermo with fantastic views over the city and the sea. From here we take our time to visit its stunning cathedral, described as one of the 'wonders of the medieval world', and climb to its roof. We stroll through the old historical centre and have time to buy some picnic supplies before travelling on to the wonderful Zingaro Nature Reserve - the oldest in Sicily. We find a spot to enjoy a picnic lunch before commencing a beautiful coastal walk along the pristine Mediterranean landscape. Upon completion of our walk there is time to relax on the beach or perhaps take a swim before transferring to the charming small village of Scopello at the entrance of the reserve, where we can enjoy an 'aperitivo'. We return to our hotel in the centre of Palermo, where the evening is free to enjoy an optional dinner in one of the nearby local restaurants that serve traditional Sicilian cuisine. (Total walking time: sightseeing walks in Palermo and Monreale + 'Zingaro' walk: around 2 hours; approx. walking distance: 8 km. Total driving time today: around 2 hours)
Hotel Joli or similar (1 nt)
Day 3 Cefalu/Montalbano
This morning we are passing the famous fish market before we travel along the northern coast to the beautiful small town of Cefalù, one of Sicily's 'undiscovered treasures'. We are dropped off at the town's Roca, the mountain with a castle built on top that overlooks the old city centre. From here we embark on a wonderful short round walk before continuing down into the old town and discovering its charming narrow alleyways and imposing Norman cathedral. After lunch there may be the possibility for a swim before we continue our travels along the north coast to Tindari. After visiting the intriguing ruins of the old Greek city of Tyndaris, we can pay a short visit to the sanctuary - one of the most important places of worship in Sicily, before visiting the intriguing ruins of the old Greek city of Tyndaris, where we take a wonderful afternoon walk through the ruins, overlooking the Mediterranean. Energy levels permitting we can continue our walk down to the coast. We walk along spectacular sand formations and green-blue lakes, before returning to our bus. We drive inland to the charming medieval town of Montalbano, dominated by its impressive castle, listed as one of the hundred most beautiful small towns of Italy. We settle in a great hotel, overlooking the coast and the Eolian Islands. (Total walking time: around 3hours; approx. walking distance: 7 km. Total driving time today: around 3 hours)
Hotel Federico II or similar (1 nt)
Day 4 The Malabotta Forest/Argimusco
Today is a relaxed day. After a leisurely breakfast this morning, we start the day with a short walk through the alleys of Montalbano Elicona, with its interesting medieval town centre and a visit to its impressive castle, recently restored. We then travel on by private bus to the forest of Malabotta, a beautiful and unknown nature reserve of inland Sicily. From here we embark on a round walk, partly through the forest, partly along strange rock formations, locally known as 'megaliti'. An ancient megalithic site, now known as the 'Sicilian Stonehenge' has recently been discovered here. We have our lunch with local specialties in the forest, with views of Mount Etna, in front of us. If energy levels permit we continue our walk to Moio dell'Alcantara, where we can see the 'Vulcanetto', a small volcano just outside the village. We then return to our hotel, in time for a nice 'aperitivo' at sunset, before having dinner at the hotel. (Total walking time: approx. 4 hours; walking distance: approx. 9 km).
Hotel Federico II or similar (1 nt)
Day 5 Taormina/Castelmola/Isola Bella
Today we travel on to our next base, the wonderful resort town of Taormina, situated in one of the most dramatic spots of the whole Mediterranean. Our bus first brings takes us to the charming hilltop town of Castelmola, a small fortified city, from where we enjoy stunning views over the surrounding area, the city of Taormina, Mount Etna and the Mediterranean Sea. After a stroll through its medieval streets, an optional visit to the castle and perhaps a drink on one of the terraces, we walk on, down to Taormina, along a beautiful panoramic footpath. Through pleasant agricultural landscape, with breathtaking views of the coastline and glorious Etna, we reach the charming Taormina, not without reason one of Italy's foremost resort towns. The Greek influence is noticeable in the architecture and wandering the back streets is a great way to transport you back in time to the days when this part of Italy remained a stronghold for their Aegean neighbours. With picturesque ruins and the backdrop of Etna, views are grand to say the least. Here we make a first orientation walk through the charming small streets of town, its gardens and of course to visit the world famous Greek/Roman theatre and the cathedral. The whole afternoon is at leisure, so plenty of time for another stroll along Taormina's main boulevard, with its many beautiful shops, or to have a drink in the shade of an oleander tree, or return to the hotel and enjoy its panoramic swimming pool. Those who want can join in for an optional walk down to the sea, which we reach in front of the beautiful Isola Bella (what's in a name!). Here we have time for a swim/ relax at the beach and a drink in the Mediterranean sun. In the late afternoon we take the cable car back up to town and from there we return to our hotel, passing along a spectacular medieval staircase. From our hotel we have perhaps the best possible views on Mount Etna and the Mediterranean Sea, which can even be enjoyed from the swimming pool! Tonight we have dinner together in a great restaurant, with stunning views over Taormina and the Sicilian coastline. After dinner we can take a 5 minute walk to one of the most spectacular viewpoints of the area. (Total walking time: approx. 3.5 hours; walking distance: approx. 9-11 km).
Hotel Sole Castello or similar (1 nt)
Days 6-7 Mt Etna
After breakfast a private minibus picks us up from our base for a full day visit to Mount Etna. Firstly we drive into the valley of the Alcantara river, irrigated by a complex system of basins and canals, dating back to the times of the Arab domination of Sicily. We stop at the unique canyon cut through an ancient lava flow of Mount Etna. Here we take a short & easy, but spectacular walk through the canyon. We then travel on towards Francavilla, where we walk along the river, through a pleasant terraced landscape of orchards and fruit trees and pass a few hamlets built of lava stone and will also have the opportunity to see many strange lava formations, sculpted by the Alcantara River. We may also have the opportunity to dive into one of the 'gurne', natural 'swimming pools'. We then continue along the Alcantara river, up to the charming little town of Linguaglossa, where we can enjoy a typical 'granita' or a coffee and a wonderful sweet (almond/pistachio) cake from this area. Our journey then takes us up along the scenic Via 'MareNeve', the road of the sea and snow. From here we can see the most recent lava flows, some of which date back only a few years, reminding us of the fact that the Etna is still an active volcano! We walk on one of these recent lava flows, with a visit to some of the spots where the lava burst. This walk really gives us the feeling of the immense forces still working beneath us. Our bus then brings us to the Sartorius Mountains, a completely different landscape, and from here we walk, partly through the forest, partly over older lava flows, ending at a mountain hut with spectacular views over the Strait of Messina. There is also time today to enjoy a wine tasting in one of the renowned wineries of Mount Etna, overlooking the sea. It's then on to the southern side of Mount Etna, perhaps the best-known part, again completely different in landscape. We settle into our next base, a charming hotel on the southern slopes of Mount Etna and the highest hotel on the Etna. (Total walking time on day 6: approx. 4 hours; walking distance: approx.7 km. Total driving time today: around 1.5 hours).
The following day you will travel towards the very top of Mount Etna, for a full day visit to the top of the volcano. After breakfast you will travel up by cable car and 4x4 vehicles, until you reach almost 3000 metres in altitude.Then, together with a specialist volcano guide you will start the relatively easy walk towards the very top, which you will notice is not just one, but a series of crater peaks.After a short stop for a snack and a drink you will visit the other highest craters here, a unique experience! From here you will start your downhill walk, passing along a marvellous viewpoint above the Valle del Bove, Etna's largest valley, in which many lava flows can be seen, one atop of the other.If there is volcanic activity going on your specialist guide can take you there, to allow you to observe these impressive forces of nature from a safe point. You will then walk back to the cable car.Those who are after a longer walk – all downhill - can walk all the way back to the base. In case of adverse weather conditions, you will not go all the way to the top, but instead take a round walk over one of the most impressive cones, the Montagnola, and along the edge of the Bove Valley.Back near your base, you can go for a short but spectacular walk along the Monti Silvestri, through the barren landscape formed by the explosion of 1892.After a short stop for a drink you will then walk back to your base and spend another night on the top of Mt. Etna. Approximately 4-5 hours; walking distance: approx. 13-17 km. Different options available, according to weather conditions and fitness)
Included Activities
- Mount Etna Day Trip
- Wine Tasting
- Guided tour to the summit of Mount Etna
Hotel Corsaro or similar (2 nts)
Day 8 Pantalica/Ragusa
This morning we drive south under the shadow of Mount Etna to the charming baroque town of Sortino, which dominates the Anapo River valley. After a short stop in Sortino , where we can take a stroll and buy our picnic supplies we drive to the entrance of the canyon of the Anapo River. This one of the most intriguing places in Sicily. The valley has been inhabited since prehistoric times and many civilisations have left their mark here. We take a walk through the valley, firstly through the higher parts along the various prehistoric burial sites, known as the necropolis of Pantalica, and its most impressive monument - the Palace of the Prince. We also encounter small chapels, Byzantine villages and, at the edge of the canyon, beautiful baroque churches. We enjoy a picnic lunch on a nice spot in the valley. After lunch we continue our walk following the course of an old railway. Along the river there are several good spots for a rest and perhaps a swim in one of the small lakes. At the end of our walk, we are picked up by our vehicle and are transferred to the town of Ragusa, one of the most scenic Sicilian towns and that also blends in wonderfully into its surrounding landscape. The 'new' baroque city of Ragusa was completely rebuilt after the devastating earthquake of 1693, but the historic part of the town still features older monuments. Both parts of the town deserve a visit. At night we can stroll through the wonderful baroque streets and choose from a range of restaurant options for dinner. (Total walking time: around 3,5 hours; approx. walking distance: 9 km. Total driving time today is around 2.5 hours)
Montreal Hotel or similar (1 nt)
Day 9 Ibla/Modica/Noto/Vendicari Nature Reserve
Today we start with a short stroll through Ragusa, which is equally beautiful by day, as it is at night. We then travel on to Modica, yet another wonderful baroque city, famous for its precious chocolate, made for centuries according to the same secret recipe. A short coffee break allows us to soak up its atmosphere. Then we travel on to the nature reserve of Vendicari, one of the last remaining pristine bits of coastline in Sicily. Here we do a relaxed coastal walk, with the possibility to go for a swim. By mid afternoon we leave for nearby Noto, perhaps the best known of the baroque cities, where we admire the wonderful colours of its many monuments in the beautiful late afternoon light. At the end of the afternoon, we will be picked up by our bus again. Shortly we arrive in Siracusa, an ancient town on the sea, which was of immense importance as Greek Syracuse. Our hotel is located in the middle of the lovely historical heart, located on the island of Ortigia. Here you will see that the much of its charm lies in wandering down the narrow medieval lanes, past romantically crumbling Baroque and medieval palaces and churches. We can eat something together in one of the lively restaurants in the historical centre, and if energy levels permit we make a nice roundwalk in the evening to savour its typical Mediterranean atmosphere. Total walking time: approx. 3.5 hours; walking distance: approx. 9 km. Total driving time today is around 2 hours.
Hotel Alla Giudecca or similar (1 nt)
Days 10-11 Syracuse/Ortigia/Neapolis
After breakfast we walk directly from our hotel through the most interesting parts of the old town. We discover many archaeological areas (some are amongst the world's finest), countless baroque churches and many other important monuments. The character of the city is enchanting with its crumbling facades with balconies supported for centuries by a host of stone lions, tigers, bears, dragons, Moors, satyrs, devils, angels, kings, paupers, wenches and cherubs. We also walk along limestone-paved streets overhung with drying laundry and ancient scaffolding and discover some of the most expansive piazzas that Italy has to offer. Passing some open doors will give us a glimpse of an ornate secret court yard, whilst others open right on to someone's dining room where lunch is being prepared. We have ample time to stroll around the old city, visit its monuments and enjoy a coffee or savour a granita in one of the lively bars. Syracuse's superb archaeological zone boasts the largest Greek theatre, which is still used today for live performances. The rest of the day is free and your tour leader can help with some suggestions of things to see and do. Options include a boat trip around the island of Ortigia or a bike ride through the old city. From Syracuse it's easy to reach the nature reserve of Fiume Ciane, the only place in Europe where the papyrus plant grows, or a local beach. The city also has a great shopping district to explore. This evening we can gather together for an optional farewell dinner - a great opportunity to reflect on our just-completed adventure.
Your trip will come to an end after breakfast in Syracuse. There are a number of shuttle bus and train services to onward destinations including Catania (airport) and Messina.The bus station is within walking distance of the hotel and the train station is also close by.Arrivederci!
Hotel Alla Giudecca or similar (1 nt)
Also available to purchase
For many of our trips we have other services or experiences that are also available to purchase to extend your trip or to make your holiday a little easier. Below is a list of other travel products you can purchase in conjunction with this trip.
- Spirit of Sicily - Single Supplement (ZGKS)
We also recommend
If this trip is not quite right for you, cast your eye over these alternatives:
- Highlights of Sicily (ZMSL)
- Italy Experience (ZMKF)
- The Cinque Terre Explored (ZGXT)
Itinerary disclaimer
Occasionally our itineraries are updated during the year to incorporate improvements stemming from past travellers' comments and our own research. The information given in this itinerary may be slightly different to that in the brochure. It's very important that you print and review a final copy of your Trip Notes a couple of days prior to travel, in case there have been changes that affect your plans. If you have any queries, please contact your travel agent or our staff in Australia. We are here to help you!Please note that while we operate successful trips in this region throughout the year, some changes may occur in our itineraries due to inclement weather and common seasonal changes to timetables and transport routes. This can happen with little notice so please be prepared for modifications to the route. The order and timing of included activities in each location may also vary from time to time.
Culture shock rating
At times local life here will be familiar to that of back home, and at times very different. Services are available most of the time, English may not be the native language, and there may be some cultural differences.
Physical rating
This trip will raise your heartbeat. Moderate physical activities are included and a good level of fitness is required.
Included activities
Included activities are listed in the day-to-day itinerary, all other activities are optional and at your own expense. If you choose not to participate in the included activities on this itinerary, the cost will not be refunded.
Optional activities
A selection of optional activities are listed in the day-to-day itinerary. This isn't an exhaustive list and should be used as a guide only. Prices are approximate and are for entrance only and don't include transport to and from the sites or local guides unless indicated. All activities are subject to availability and it may not be possible to do all the activities listed in the time available at each destination. Where activities are considered medium or high risk, we work with operators whose safety and credentials we have sighted and assessed. This means that it is possible that you may find the same activity cheaper with another operator on the ground, however we cannot vouch for the safety or quality of that operator. Activities not listed above have not been assessed by us and as such our staff and leaders are unable to assist you with booking these activities. The decision to partake in any activity not listed is at your own discretion and risk.
Money Exchange
The Euro (EUR) is the official currency in the following destinations: Andorra, Austria, Belgium, Cyprus, Estonia, Finland, France, Germany, Greece, Ireland, Italy, Kosovo, Latvia, Lithuania, Luxembourg, Malta, Montenegro, the Netherlands, Portugal, Slovakia, Slovenia, Spain. All other European countries still have their own national currencies.The most convenient and cheapest way to acquire money is via an Automated Teller Machine (ATM) or Bancomat as they are often referred to. Check with your bank in advance concerning the suitability of your account / card overseas and any international fees that will be applied.You can obtain local currencies easily at airports and major train stations, but be sure to bring some extra emergency cash in a major currency that can be exchanged if the ATMs are not functioning.When leaving home don't forget your PIN and make sure you know the telephone number for cancelling your card if it is stolen. Keep this in a safe place.Credit cards are not always accepted in stores and restaurants. While travelling we recommend you carry some cash to pay for restaurant bills and other services. Change can be difficult to obtain so throughout the day, try to gain as many small denominations as you can.You might be advised to take some of your money as travellers' cheques from a major financial institute. Travellers' cheques have security advantages, however please be aware that the exchange rates may not be favourable and that it is difficult to change Travellers' cheques in most countries. Be particularly aware that after hours money exchanges and hotel receptions carry high commissions- sometimes up to 20%.For money safety we recommend that you carry your cash and credit cards in a secure money belt or pouch concealed under your clothes.
Spending money
Every traveller is different and therefore spending money requirements will vary. Some travellers may drink more than others while other travellers like to purchase more souvenirs than most. Please consider your own spending habits when it comes to allowing for drinks, shopping, participating in optional activities, and tipping. Please also remember the following specific recommendations when planning your trip.
On this trip, we have included gratuities for the essential services that you will receive as part of your tour package. This will cover tips to drivers, specialist local guides (where applicable), restaurant staff for included meals, porters, bellboys and other hotel staff, including room-cleaning staff.This amount DOES NOT include a tip for your tour leader, so you may wish to set aside some funds for this. It is customary to tip your tour leader for outstanding service throughout your trip. The amount is entirely a personal preference; however as a guideline €EUR2-4, or the equivalent in any currency used on the trip, per person, per day can be used. Of course you are free to tip more or less as you see fit, depending on your perception of service quality and the length of your trip. Remember, a tip isn't compulsory and should only be given when you receive excellent service.You also wish to put aside some money for your own tipping, such as when you are doing our own optional sightseeing or activity that involves local guides and/or drivers or when joining in optional groups meals or dining out on your own. In these instances, we advise you to carry small notes of local currency each day to make tipping easier. The amounts can vary greatly according to destination, so we suggest that you ask your tour leader to give you guidance on what are appropriate amounts to tip.
Departure tax
All departure taxes should be included in your international flight ticket.
Please note that you are responsible for your own visas and taxes. Please have these amounts available prior to departing the various countries.
Important notes
This trip is operated by Peregrine Adventures and you will be joined by other like minded Intrepid and non Intrepid travellers. Single travellers will share accommodation with another traveller of the same sex.
This trip is operated by Peregrine Adventures and you will be joined by other like minded Intrepid and non Intrepid travellers. Single travellers will share accommodation with another traveller of the same sex.
Group size
Maximum of 16 travellers per group.
Your fellow travellers
As you travel on a group trip you will be exposed to all the pleasures and maybe some of the frustrations of travelling in a group. Your fellow travellers will probably come from all corners of the world and likely a range of age groups too. We ask you to be understanding of the various needs and preferences of your group - patience with your fellow travellers is sometimes required for the benefit of everyone's travel experience. Remember too that you have responsibilities to the group. If you are requested to be at a place at a certain time, ensure that you don't keep the rest of the group waiting. We have found time and time again that the very best trips we operate are those where the dynamics within the group work well - this takes just a little effort on your part. Due to privacy reasons we are unable to provide you with contact details and any personal information about your fellow travellers booked on your trip prior to departure.
Single travellers
Our group trips are designed for shared accommodation and don't involve a compulsory single supplement. Single travellers share with people of the same gender in accommodation ranging from twin to multishare. Some of our itineraries have accommodation booked on a mixed gender share basis and where applicable this will be specified in our Trip Notes. On a selection of our trips, you have the option to pay a single supplement to ensure that you have your own accommodation (where available). Please note that this only applies to accommodation during the tour - pre-trip and post-trip accommodation will be booked on a single room basis.
A single supplement is available on this trip, please refer to your booking agent for further information.
Hotel Joli or similar (2 nts), Hotel Federico II or similar (2 nts), Hotel Corsaro or similar (2 nts), Hotel Alla Giudecca or similar (2 nts), Hotel Sole Castello or similar (1 nt), Montreal Hotel or similar (1 nt)
The style of accommodation indicated in the day-to-day itinerary is a guideline. On rare occasions, alternative arrangements may need to be made due to the lack of availability of rooms in our usual accommodation. A similar standard of accommodation will be used in these instances.TWIN SHARE / MULTI SHARE BASIS
Accommodation on this trip is on a twin/multishare basis. Please note there may be times where facilities will be shared rather than ensuite and rare occasions when you share a room with passengers travelling on different Intrepid trips than your own. CHECK-IN TIME
Throughout the trip we request that our hotels prepare rooms in time for our arrival, especially if we're arriving prior to normal check-in time. However this isn't always possible which means we won't be able to check-in immediately on arrival at some hotels. Instead, we can store our luggage and explore our new destination.PRE/POST TRIP ACCOMMODATION
If you've purchased pre-trip or post-trip accommodation (if available), you may be required to change rooms from your trip accommodation for these extra nights.
The style of accommodation indicated in the day-to-day itinerary is a guideline. On rare occasions, alternative arrangements may need to be made due to the lack of availability of rooms in our usual accommodation. A similar standard of accommodation will be used in these instances.TWIN SHARE / MULTI SHARE BASIS
Accommodation on this trip is on a twin/multishare basis. Please note there may be times where facilities will be shared rather than ensuite and rare occasions when you share a room with passengers travelling on different Intrepid trips than your own. CHECK-IN TIME
Throughout the trip we request that our hotels prepare rooms in time for our arrival, especially if we're arriving prior to normal check-in time. However this isn't always possible which means we won't be able to check-in immediately on arrival at some hotels. Instead, we can store our luggage and explore our new destination.PRE/POST TRIP ACCOMMODATION
If you've purchased pre-trip or post-trip accommodation (if available), you may be required to change rooms from your trip accommodation for these extra nights.
Your accommodation may not always have air-conditioning. European hotels generally don't provide kettles or fridges.
Meals introduction
While travelling with us you'll experience the vast array of wonderful food available in the world. Your group leader will be able to suggest restaurants to try during your trip. On our camping trips we often cook the region's specialities so you don't miss out. To give you the maximum flexibility in deciding where, what and with whom to eat, generally not all meals are included in the trip price. This also gives you more budgeting flexibility. As a rule our groups tend to eat together to enable you to taste a larger variety of dishes and enjoy each other's company. There's no obligation to do this though.
10 Breakfasts, 2 Lunches, 6 Dinners
Please budget for additional meals and expenses while on your trip. Our suggestion is based on past traveller feedback but you may choose to spend more or less.
Minibus, Cable car, 4x4
Group leader
All Intrepid group trips are accompanied by one of our group leaders. The aim of the group leader is to take the hassle out of your travels and to help you have the best trip possible. Intrepid endeavours to provide the services of an experienced leader however, due to the seasonality of travel, rare situations may arise where your leader is new to a particular region or training other group leaders.Your leader will provide information on the places you are travelling through, offer suggestions for things to do and see, recommend great local eating venues and introduce you to our local friends. While not being guides in the traditional sense you can expect them to have a broad general knowledge of the places visited on the trip, including historical, cultural, religious and social aspects. At Intrepid we aim to support local guides who have specialised knowledge of the regions we visit. If you were interested in delving deeper into the local culture at a specific site or location then your leader can recommend a local guide service in most of the main destinations of your trip.
Joining point
Hotel Joli
Via Michele Amari, 11
Phone: +39 091 6111765
Joining point instructions
BY AIRThe main airport in Palermo is the 'Falcone-Borsellino Airport at Punta Raisi which is about 35 kilometres west of Palermo. From here there are regular flights from many cities in Italy, but also international flights and a number of 'low cost' charter flights. For example Easyjet fly from London Gatwick into PalermoFrom Palermo airport there is a frequent, quick and cheap 'shuttle train' service to Palermo, the 'Trinacria Express'. The fare is €5.50 (April 2010). Airport ticket office: +39 091 7044007.There are also frequent buses from the airport to Palermo that run every half hour from 6.30 to 24.00. The ticket price is € 5.80 (Autolinee Prestia e Comandè. Tel. +39 091 580457).There are two stops in Palermo near your hotel: via Emerico Amari (Port) and Politeama. Both are at only a few hundred metres walk from Piazza Florio. Ask the driver which is the most convenient (normally Piazza Politeama – but he might be able to leave you closer).When you get off the bus at Piazza Politeama: continue on foot along the Via Emerico Amari for about 200 metres and as soon as you spot Via Michele Amari, turn right here. Continue until the square and within 1 minute you are at the hotel.The airport's taxi service is in operation from 06.00 to 24.00. Taxi's can be found outside the Arrivals Area. There are pre-established fares from Palermo to the airport and vice versa. The ride to your hotel (Piazza Florio) should cost about € 35 euro (in the C.so Calatafimi/Corso V.Emanuele – range). To call a taxi: Coop. Trinacria: +39 091-225455 / Coop. Autoradio taxi tel: +39 091-513311.BY SEAThe harbour of Palermo is very close to the joining hotel, from the Port you will be able to reach the hotel very easily on foot in about 5 minutes: leave the harbour through the main entrance/exit and keep going straight, along the Via Emerico Amari for about 250m. until you reach Via Michele Amari (4th road on the left). Turn left here, and pass the square (Piazza Florio). The hotel can be found at no.11, just past the square.There are taxis at the harbour normally, especially when the big boats arrive. To call a taxi: Coop. Trinacria: +39 091-225455 / Coop. Autoradio taxi tel: +39 091-513311. The fare should be about 10 euro (3 minutes by car).BY TRAINThe main train station of Palermo is not very close to the hotel. There are very frequent bus services though, which along the main road (Via Roma) go towards the Politeama.From the station you can take any bus which runs along Via Roma in northern direction. The 'Linea Rossa' (red line) brings you close to your hotel. See: www.amat.pa.it/Pagine/Navigatore/centro_storico.swfBus tickets can be bought at several shops, newspaper agents', bars, drugstores etc. and at AMAT Points. One-way tickets cost € 1,20 and have a validity of 90 minutes. Tickets can also be bought on board from the driver and cost 40 cents more.There are usually taxis waiting at the train station but if not, to call a taxi: Coop. Trinacria: +39 091-225455 / Coop. Autoradio taxi tel: +39 091-513311. The fare should be about 10-15 euro maximum (5 minutes by car; depending on traffic).
Arrival complications
We don't expect any problems (and nor should you) but if for any reason you are unable to commence your trip as scheduled, please contact your starting point hotel, requesting that you speak to or leave a message for your group leader.Please also make sure have a copy of the local operator's emergency phone numbers from our Emergency Contact section of these trip notes.
Finish point
Hotel Alla Giudecca
Via Alagona 52
Phone: +39 093122255
Fax: +39 093162433
Finish point instructions
BY RAIL for Catania or Naples/RomeThe walk from the hotel to the train station of Syracuse takes about 15 minutes. You can also take a taxi which costs about 10 euro.From Syracuse train station there are not many trains. The journey by train to Catania takes slightly more than 1 hour. From Catania there are Eurostar trains to Rome (travelling time is approximately 8 hours). Some of these trains also operate directly from Syracuse). Ask for the most recent timetables at the reception of the hotel. You can also check these at Italian national rail site: www.trenitalia.itBY BUS (to Catania and Catania airport and to Palermo)From Syracuse there are many direct buses to Catania / Catania Airport and also direct to Palermo without the need to pass through Catania.The walk to the bus station of Syracuse takes also takes about 15 minutes. You can also take a taxi from the hotel to the bus station which costs about 10 euro. It is actually not a real bus 'station', but a number of bus stops (of different companies) located in a street near the train station.The journey to Catania takes about 1 hour. The journey to the Catania airport takes about 15 minutes. The ride to Palermo takes about 4 hours.Important note:. Be sure to take the right bus if going to go to the airport. The only company allowed to enter the airport is the AST-company. The 'Interbus' will leave you along the road about 500 metres walking distance from the actual airport (along an unpleasant & busy road).BY AIR (from Catania airport)From Catania International airport (which is accessible by bus from Syracuse, as per above), there are flight connections to the Italian mainland and other destinations in Europe. For more information visit: http://www.aeroporto.catania.it.
Emergency contact
In the case of genuine crisis or emergency please call our partner Genius Loci on their 24 hour emergency number
Tel: 00 39 393 93752799
For further contact details please use the following page:
Tel: 00 39 393 93752799
For further contact details please use the following page:
Emergency funds
Please also make sure you have access to an additional US$500, to be used when unforeseen incidents or circumstances outside our control (eg. a natural disaster, civil unrest, strike action or an outbreak of bird flu) necessitate a change to our planned route.
Visas are the responsibility of the individual traveller. The visa requirements for your trip vary depending on where you are from and where you are going. As a general rule most countries expect that you will have at least 6 months' validity on your passport. On arrival visitors may be asked to present return tickets and evidence of means to cover your intended stay. We keep the following information up to date as much as possible, but rules do change - it's important that you check for yourself. Residents from other countries must consult the relevant embassies or your travel agent.
Australia: No - Not required
Belgium: No - Not required
Canada: No - Not required
Germany: No - Not required
Ireland: No - Not required
Netherlands: No - Not required
New Zealand: No - Not required
South Africa: Yes - in advance
Switzerland: No - Not required
UK: No - Not required
USA: No - Not required
Australia: No - Not required
Belgium: No - Not required
Canada: No - Not required
Germany: No - Not required
Ireland: No - Not required
Netherlands: No - Not required
New Zealand: No - Not required
South Africa: Yes - in advance
Switzerland: No - Not required
UK: No - Not required
USA: No - Not required
Issues on your trip
While we always endeavour to provide the best possible holiday experience, due to the nature of travel and the areas we visit sometimes things can and do go wrong. Should any issue occur while you are on your trip, it is imperative that you discuss this with your group leader or our local representative straight away so that they can do their best to rectify the problem and save any potential negative impact on the rest of your trip.We recognise that there may be times when your group leader/local partner may not be able to resolve a situation to your satisfaction - if this is the case, please ask the leader to speak to their direct manager.You may also choose to provide details in your online feedback, which we ask you to complete within 30 days of the end of your trip. But we do ask you to be aware that it is very difficult for us to provide any practical help after the trip is complete.
What to take
On this trip, you must pack as lightly as possible because you will be expected to carry your own bag and although you won't be required to walk long distances with your luggage (max 30 minutes), we strongly recommend keeping the weight under 10kg / 22lb.Most travellers carry their luggage in a backpack, although an overnight bag with a shoulder strap would suffice if you travel lightly. Smaller bags or backpacks with wheels are convenient although we recommend your bag has carry straps to accommodate the cobbled streets, uneven surfaces, stairs and steps you are lightly to encounter while carrying your luggage. You'll also need a day pack/bag to carry water and a camera etc for day trips.You can find Intrepid's Ultimate Packing List on our website. It should be used as a guide only and isn't intended to be a complete packing list.
On this trip, you must pack as lightly as possible because you will be expected to carry your own bag and although you won't be required to walk long distances with your luggage (max 30 minutes), we strongly recommend keeping the weight under 10kg / 22lb.Most travellers carry their luggage in a backpack, although an overnight bag with a shoulder strap would suffice if you travel lightly. Smaller bags or backpacks with wheels are convenient although we recommend your bag has carry straps to accommodate the cobbled streets, uneven surfaces, stairs and steps you are lightly to encounter while carrying your luggage. You'll also need a day pack/bag to carry water and a camera etc for day trips.You can find Intrepid's Ultimate Packing List on our website. It should be used as a guide only and isn't intended to be a complete packing list.
All Intrepid travellers need to be in good physical health in order to participate fully on this trip. When selecting your trip please make sure you have read through the itinerary carefully and assess your ability to cope with our style of travel. Please note that if, in the opinion of our group leader or local guide, any traveller is unable to complete the itinerary without undue risk to themselves and/or the rest of the group, Intrepid reserves the right to exclude them from all or part of a trip without refund.You should consult your doctor for up-to-date medical travel information or for any necessary vaccinations and anti-malarial requirements before departure. We recommend that you carry a first aid kit as well as any personal medical requirements (including a spare pair of glasses) as they may not easily be obtained at the locations on this trip. For legal reasons our leaders and guides are prohibited from administering any type of drugs including headache tablets and antibiotics. Please ensure that you are adequately prepared.
Many national governments provide a regularly updated advice service on safety issues involved with international travel. We recommend that you check your government's advice for their latest travel information before departure and ensure that your travel insurance covers you for all areas your itinerary covers. Please refer to our website's safety page for links to major travel advisories and updates on safety issues affecting our trip.We strongly recommend the use of a neck wallet or money belt while travelling, for the safe-keeping of your passport, air tickets, cash and other valuable items. Leave your valuable jewellery at home - you won't need it while travelling. Many of our hotels have safety deposit boxes, which is the most secure way of storing your valuables. A lock is recommended for securing your luggage.Your leader will accompany you on all included activities, however during your trip you'll have some free time to pursue your own interests, relax and take it easy or explore at your leisure. While your leader will assist you with the available options in a given location, please note that any optional activities you undertake are not part of your Intrepid itinerary, and Intrepid makes no representations about the safety of the activity or the standard of the operators running them. Please use your own good judgement when selecting an activity in your free time. Please also note that your Leader has the authority to amend or cancel any part of the trip itinerary if it's deemed necessary due to safety concerns.For more details on the type of conditions and safety standards you can expect on your trip, please refer to Intrepid's operational safety policy on our website. We recommend that you take a moment to read through this information before travelling, and would appreciate any feedback on how well it's being implemented in the field:
Please be aware that local laws governing tourism facilities in this region differ from those in your home country and not all the accommodation which we use has a fire exit, fire extinguishers or smoke alarms.
Please be aware that local laws governing tourism facilities in this region differ from those in your home country and not all the accommodation which we use has a fire exit, fire extinguishers or smoke alarms.
Depending on where you come from please note that drivers in this part of the world may drive on the opposite side of the road from what you are used to. Look both ways before crossing any road. Traffic can be a little more chaotic than you might be used to at home. Be aware!
Depending on where you come from please note that drivers in this part of the world may drive on the opposite side of the road from what you are used to. Look both ways before crossing any road. Traffic can be a little more chaotic than you might be used to at home. Be aware!
While travelling there is always the risk of pick-pocketing and petty theft, particularly in the more touristy cities. We recommend that you exercise caution when walking alone at night and encourage you to walk together and only on main, well-lit thoroughfares. Be particularly vigilant on public transport. Simple measures like carrying your day pack on your front, not hanging your bag over the back of your chair or on the floor and wearing a money belt will reduce any chance that your valuables should go missing.
While travelling there is always the risk of pick-pocketing and petty theft, particularly in the more touristy cities. We recommend that you exercise caution when walking alone at night and encourage you to walk together and only on main, well-lit thoroughfares. Be particularly vigilant on public transport. Simple measures like carrying your day pack on your front, not hanging your bag over the back of your chair or on the floor and wearing a money belt will reduce any chance that your valuables should go missing.
Travel insurance
Travel insurance is compulsory for all our trips. We require that, at a minimum, you are covered for medical expenses including emergency repatriation. We strongly recommend that the policy also covers personal liability, cancellation, curtailment and loss of luggage and personal effects.When travelling on a trip, you won't be permitted to join the group until evidence of travel insurance and the insurance company's 24 hour emergency contact number has been seen by your leader.If you have credit card insurance your group leader will require details of the participating insurer/underwriter, the level of coverage, policy number and emergency contact number rather than the bank's name and credit card details. Please contact your bank for these details prior to arriving in-country.Please go to our website for links to various travel insurance providers:
Responsible Travel
We believe strongly in low impact or rather positive impact tourism. Broadly speaking this means that we try to minimise the negative aspects of tourism on the local cultures and environments that we visit and highlight the positive aspects. Please visit our website for further details and suggestions on how you can be a responsible traveller:
A couple of rules
Illegal drugs will not be tolerated on our trips. Possessing or using drugs not only contravenes the laws of the land, but also puts the rest of the group at risk. Smoking marijuana and opium is a part of local culture in some parts of the world but is not acceptable for Intrepid travellers. Intrepid's philosophy of travel is one of respect towards everyone we encounter and in particular, the local people who make our destinations such special places. The exploitation of prostitutes is completely contrary to this philosophy. Our group leader has the right to expel any member of the group if drugs are found in their possession or if they use prostitutes.Everyone has the right to feel safe and secure on their trip. We don't tolerate any form of sexual harassment at Intrepid, either between passengers or involving our leaders or local operators. Sexual relationships (consensual or otherwise) between a leader and a passenger are unacceptable. If you ever feel another person is behaving inappropriately please inform us immediately by contacting the emergency contact number detailed in these trip notes.
The Intrepid Foundation
Since Intrepid Travel commenced operating in 1989 we've been committed to giving something back to the communities we visit. One way has been through our support for local humanitarian, development and conservation projects. Many of our travellers want to contribute something too. Whilst it is often tempting to give hand-outs to those less fortunate, this has the potential to promote a culture of begging and dependency. Handouts are not a sustainable way for individuals or communities to live. That's why we established The Intrepid Foundation – to make it easier for travellers wishing to give back to communities in an effective and meaningful way. The Intrepid Foundation is a not-for-profit fund offering a selection of excellent grassroots organisations which you can contribute to. All donations to The Intrepid Foundation will be matched by Intrepid Travel dollar for dollar (up to AU$1,000 per donor and a total of AU$400,000 for all donors in each financial year, excluding emergency appeals). And every cent gets there as Intrepid Travel pays for all the administration costs. Donating is simple and secure. Please ask your leader for information on the projects we support through The Intrepid Foundation or go to our website:
Carbon offset
Carbon Offset C02-e 192.00 kgs per pax.
After your travels, we want to hear from you! We rely on your feedback. We read it carefully. Feedback helps us understand what we are doing well and what we could be doing better. It allows us to make improvements for future travellers.


text:
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subset: commoncrawl


text:
Ford is recalling a total of 203,494 vehicles in North America in two campaigns. One of them covers an issue with the instruments in the Escape and Transit. The other is a small labeling issue for the Transit.
Ford Transit
12Ford recalls 200K Escape, Transit Connect models over instrument panel
176Ward's calls out Ford's EcoBoost engines for their crummy fuel economy
- Brandon Turkus
- Jan 7, 2015
- 176
17Ford announces bevy of recalls, 2 of which are recalls on recalls
6Ford Transit customs ready to work for SEMA
9Ford Transit gets outfitted for prison duty
21Mercedes-Benz Sprinter and Ford Transit can haul on the track
- Chris Bruce
- Aug 19, 2014
- 21
6Ford issues four recalls covering 163k vehicles
1252015 Ford Transit First Drive
104Your official Ford Transit specs are here, $29,565* to start
AddPeel and Ford Transit do a great Austin Powers impression
- Brandon Turkus
- May 5, 2014
- Add
33Ford Transit production fires up, American Pickers among first takers
7Ford E-Series chassis cabs and cutaways to survive mass Transit onslaught [UPDATE]
9Ford Transit Skyliner Concept does discreet luxury in NYC
20Ford Transit Skyliner Concept is a Gulfstream for the road
28Ford moving medium-duty F-Series production from Mexico to Ohio
- Chris Bruce
- Feb 27, 2014
- 28
392014 Ford Transit Connect Taxi hopes to fare thee well
7Wrap up some fun with Ford's commercial vehicle configurator
- Damon Lowney
- Aug 27, 2013
- 7
76Top Gear in dustup over alleged staged hovercraft scene [w/video]
- Brandon Turkus
- Jul 29, 2013
- 76


text:
Muscat: A magnitude-5.6 tremor struck 48 kilometres off the coast of Kish Island early in the morning on Wednesday.
The US Geological Survey (USGS) reported the mild quake hit close to the Iranian island at around 05:00 Oman time.
The USGS located the quake epicentre in southern Iran, some 50km west-south-west of the Kish Island and 229km north-north-west of Abu Dhabi.


text:
A new report published by Harvard University claims the telecommunications industry has unlimited access to shape Federal Communications Commission (FCC) policies at the expense of public health, consumer safety, privacy, and consumer wallets.
The Corrupted Network
The report claims that the FCC, which is a government agency that is supposed to act as a regulator, sits at the heart of a "bipartisan Washington web of institutional corruption" that has for many years been championing corporate interests often at public expense. This industry stranglehold extends from:
- Its well-placed campaign spending in Congress
- Control of the FCC's Congressional oversight committees
- Persistent agency lobbying.
The report goes even further by saying that in the case of wireless radiation health issues industry control extends beyond Congress and regulators, to basic scientific research.
Troubling Body Of Evidence Linked To Negative Health Effects
Whilst guardedly describing the EMF science as "controversial" the report admits that "a troubling body of evidence suggests exposure to even low emission levels at typical cellular frequencies between 300 MHz and 3 GHz can have a wide range of negative effects."
The report goes on to cite some of the numerous studies that link wireless exposures to adverse health effects:
A 2002 study that compared the health of people living at different distances within 300 meters of cell towers with those living more than 300 meters away ―Results indicated increased symptoms the closer a person lived to a tower.… Read the rest


text:
Icelandic-Cottages 3
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With last night's loss in the first round of the second-rate National Invitational Tournament, the University of Washington men's basketball season is over.
The year featured an 8th-place conference finish, sub-par home record, and a one-and-done in a consolation tournament. The Huskies did not accomplish much. But they did do one important thing — they put a stake in one of sports' most maddeningly persistent myths.
If there was one thing every insider agreed on before college basketball season, it was that though this year's Huskies had less talent than last year's team, they had one ineffable, elusive, and — to some, necessary — component of a winning squad.
"We have great team chemistry this year," said team captain Abdul Gaddy before the season. "It's one of our strengths, and I think that's going to really help us offensively and defensively." Head coach Lorenzo Romar said the 2012-13 Huskies had "best chemistry of any team that we've had."
If that's true, we've all found out what team chemistry is good for: absolutely nothing.
The preseason storyline: Departed stars Terrence Ross and Tony Wroten, both first-round NBA draft picks, had cared more about showing off for pro scouts than sharing the ball and communicating on defense. With Ross and Wroten gone, surely the Huskies would be better on both ends of the floor.
Instead, the Huskies were worse. And not only by wins and losses, but by practically every basketball metric you can come up with, even the ones where you'd think good team chemistry would help.
Take assists, that epitome of team-oriented hoops. Last year, 49.2 percent of the Huskies' made baskets were the result of an assist. That was a dismal number, 277th in D1 basketball. This year, with ballhogs Wroten and Ross gone…only 47.6 percent of made baskets came from an assist, 304th in the country. Despite the improved team chemistry, the Huskies got worse at sharing the ball.
Same story on defense. Last year, the Huskies allowed 96.3 points per 100 possessions, for a very mediocre 101st in college. This year, with the presumed better communication and trust needed for good defense, the Huskies allowed 97.7 points per 100 possessions, 153rd in D1. Again — chemistry better, performance worse.
Where else might chemistry help a basketball team? Maybe turnover avoidance? Players on a united team should have a better sense of where open teammates are and be able to find them under duress. But while last year's Huskies were actually pretty good at avoiding turnovers, committing them on 18.6 percent of possessions, 77th in D1, this year's squad was considerably worse, committing turnovers on 20 percent of possessions, 175th in D1.
By now, those of you who cling to the importance of team chemistry the way the Catholic Church clung to the Ptolemaic system will be saying: "Be fair, the Huskies lost two NBA first-round picks. Without the wonderful team chemistry, they would've been even worse!"
But that's really the point, isn't it? Good talent is always, always, always, always, always, always, always going to win more games over the course of a season. Romar said that, of any Husky team he's coached, this one had the best chemistry. If you heard a team was the best ever at X, and they were a bad team, what would you conclude about how important X is?
Coaches prefer teams that like each other to teams that don't. Why wouldn't they? Who wants to deal with personality clashes, or players who care more about their advancement than your message? There's a reason so many business executives have embraced the "No Assholes" hiring philosophy. Problem is, assholes have an annoying way of being really good at their jobs. Some of the most successful people of the last 25 years exhibited strong asshole-ish tendencies: Steve Jobs. Michael Jordan. Bill Clinton.
I'm not saying that only jerks have talent, but that, especially in incredibly competitive fields like high-stakes college basketball (or business, or the NBA, or leading the free world), talent is too precious to sacrifice at the altar of everyone getting along.
Longtime sportswriters also frequently hype team chemistry. They're wrong, but I don't blame them. For one thing, coaches are constantly telling them how important it is. And whether consciously or subconsciously, reporters, who interact with players daily, know that an asshole-free team will make their jobs much easier. But fans, who rarely encounter players, clearly prefer talent to team chemistry. Case in point? Those Washington Huskies. This season, with a more chemically-appealing team on display, attendance dropped nearly 1,000 per game.
Team chemistry: It doesn't help you win, and it doesn't win you fans. Other than that, it's pretty important.


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Number: 0869
Aetna considers ixabepilone (Ixempra) medically necessary for members with locally advanced, recurrent or metastatic invasive breast cancer.
Aetna considers ixabepilone experimental and investigational for all other indications inclusding the following (not an all-inclsuive list):
Selection criteria are presented in the background section.Background
Ixabepilone was approved by the Food and Drug Administration (FDA) in combination with capecitabine for the treatment of patients with metastatic or locally advanced breast cancer resistant to treatment with an anthracycline and a taxane, or whose cancer is taxane resistant and for whom further anthracycline therapy is contraindicated. The FDA labeling indicates Ixabepilone as monotherapy for the treatment of metastatic or locally advanced breast cancer in patients whose tumors are resistant or refractory to anthracyclines, taxanes, and capecitabine.
Guidelines on breast cancer from the National Comprehensive Cancer Network (2013) indicate Ixempra as a single agent for recurrent or metastatic disease that is:
In a phase II study, Kim et al (2012) examined the effects of ixabepilone in patients with advanced gastric cancer previously treated with fluoropyrimidine-based chemotherapy. Asian patients with unresectable or metastatic gastric adenocarcinoma who had failed fluoropyrimidine-based chemotherapy received ixabepilone 40 mg/m(2) by 3-hour intravenous infusion every 3 weeks. The primary end-point was objective response rate (ORR). A total of 52 patients were treated (65.4 % men; median age of 56.5 years). The ORR was 15.4 % (95 % confidence interval [CI]: 6.9 to 28.1); 8 patients achieved partial responses (PR) for a median duration of 3.1 months (95 % CI: 2.6 to 4.1 months) and 26 patients (50.0 %) had stable disease SD). Median progression-free survival (PFS) was 2.8 months (95 % CI: 2.1 to 3.5 months). The most common grade 3 non-hematological toxicities were fatigue (9.6 %), decreased appetite (7.7 %), sensory neuropathy (5.8 %), and diarrhea (5.8 %). Grade 3/4 neutropenia occurred in 46.2 % of patients. The authors concluded that ixabepilone is active in Asian patients with advanced gastric cancer and shows a toxicity profile similar to those previously reported in other tumor types. These findings need to be validated in phase III clinical trials.
Vishnu et al (2012) evaluated anti-tumor activity of the combination of ixabepilone and sunitinib in pre-clinical models of chemotherapy naïve and refractory epithelial ovarian tumors, and investigated the mechanism of synergy of such drug combination. HOVTAX2 cell line was derived from a metastatic serous papillary epithelial ovarian tumor (EOC) and a paclitaxel-resistant derivative was established. Dose response curves for ixabepilone and sunitinib were generated and synergy was determined using combination indexes. The molecular mechanism of anti-tumor synergy was examined using shRNA silencing. The combination of ixabepilone and sunitinib demonstrated robust anti-tumor synergy in naive and paclitaxel-resistant HOVTAX2 cell lines due to increased apoptosis. The GTPase, RhoB, was synergistically up-regulated in cells treated with ixabepilone and sunitinib. Using shRNA, RhoB was demonstrated to mediate anti-tumor synergy. These results were validated in 2 other EOC cell lines. The authors concluded that ixabepilone plus sunitinib demonstrated anti-tumor synergy via RhoB in naive and paclitaxel-resistant cells resulting in apoptosis. This study demonstrated a novel mechanism of action leading to anti-tumor synergy and provided "proof-of-principle" for combining molecular targeted agents with cytotoxic chemotherapy to improve anti-tumor efficacy. They stated that RhoB could be envisioned as an early biomarker of response to therapy in a planned phase II clinical trial to assess the efficacy of ixabepilone combined with a receptor tyrosine kinase inhibitor such as sunitinib. To the best of the authors' knowledge, this was the first demonstration of anti-tumor synergy between these 2 classes of drugs in EOC and the pivotal role of RhoB in this synergy.
In a phase II clinical trial, Liu et al (2012) evaluated the activity of a weekly ixabepilone in men with metastatic castrate-resistant prostate cancer (CRPC) to minimize hematologic toxicity. These investigators reported the activity and toxicity of ixabepilone, administered by using a weekly schedule, in men with metastatic CRPC. Patients with metastatic CRPC received ixabepilone at 20 mg/m(2) intravenous weekly x 3, in 4-week cycles. This non-comparative study stratified patients to either a chemotherapy naive (CN), prior taxane (Tax) only, or 2 prior cytotoxic (TCx) chemotherapy arm. The primary end-point was prostate-specific antigen response by using PCWG (Prostate Cancer Working Group) 1 criteria. Secondary end-points included radiographic response when using RECIST (Response Evaluation Criteria In Solid Tumors). A total of 124 patients were enrolled, of whom, 109 were eligible (35 CN, 42 Tax, and 32 TCx) for the primary response determination in this study. Prostate-specific antigen responses were seen in 12 (34.3 %) of 35, 12 (28.6 %) of 42, and 7 (21.9 %) of 32 patients with the partial objective response in 5 (22.7 %) of 22, 2 (8.0 %) of 25, and 0 (0.0 %) of 24 patients for the CN, Tax, and TCx arms, respectively. Significant (grade 3/4) neutropenia was seen in 6 (15.4 %), 7 (14.6 %), and 9 (25.0 %); and grade 3/4 sensory neuropathy was seen in 8 (20.5 %), 12 (25.0 %), and 12 (33.3 %) for CN, Tax, and TCx, respectively. Grade 3/4 thrombocytopenia was infrequent and seen in only 1 patient on the CN and the TCx arm. The authors concluded that ixabepilone was found to have an acceptable toxicity profile when administered by using a weekly schedule with less myelosuppression compared with prior studies when using the every 3-week schedule. Single-agent activity was observed and met pre-specified activity levels for the Tax-treated arm. These findings need to be validated in phase III clinical trials.
In a phase II clinical trial, Edelman et al (2013) evaluated ixabepilone-based chemotherapy in stage IIIb/IV non-small-cell lung cancer (NSCLC), compared with paclitaxel-based chemotherapy. Tumor specimens were prospectively evaluated for β3T expression. Patients were stratified by β3T status (positive versus negative) and randomly assigned at a ratio of 1:1 to receive ixabepilone (32 mg/m(2)) and carboplatin (area under concentration-time curve [AUC], 6) or paclitaxel (200 mg/m(2)) and carboplatin (AUC, 6) for up to 6 cycles. The primary end-point was PFS in the β3T-positive subgroup. A total of 95 patients (β3T positive, 52; β3T negative, 43) received ixabepilone plus carboplatin; 96 patients (β3T positive, 49; β3T negative, 47) received paclitaxel plus carboplatin. No significant differences in median PFS were observed between arms for either subgroup (β3T positive, 4.3 months in both arms; β3T negative, 5.8 versus 5.3 months). Ixabepilone did not significantly improve overall survival (OS) for the β3T-positive subset or the overall population. Adverse events were similar between the 2 arms and comparable with those in previous studies. The authors concluded that there was no predictive value of β3T in differentiating clinical activity of ixabepilone- or paclitaxel-containing regimens. Ixabepilone did not improve PFS or OS in patients with β3T-positive tumors. β3T-positive patients had worse PFS relative to β3T-negative patients, regardless of treatment; hence, β3T expression seems to be a negative prognostic factor, but not a predictive factor, in advanced NSCLC treated with either ixabepilone or paclitaxel platinum-based doublets.
von Roemeling et al (2013) noted that metastatic renal cell carcinoma (mRCC) is more resistant to conventional cytotoxic chemotherapeutic agents than other solid tumors. Although significant progress has been made over the last decade with several novel therapeutics, these agents invariably go on to fail, largely due to either intrinsic or acquired resistance. To help overcome, or at least delay resistance, combinatorial therapies utilizing agents with disparate, and ideally complementary, mechanisms of actions are needed. In this report, these researchers assessed the novel combination of the mTOR inhibitor, temsirolimus, with ixabepilone in RCC. The authors concluded that the results demonstrated synergy in multiple cell lines of RCC and further evaluation of this combination is warranted in the clinical setting.
Smaglo et al (2014) stated that the management of metastatic pancreatic adenocarcinoma is a challenge for medical oncologists because of both the aggressive nature of the disease and the relative paucity of effective systemic treatments with activity against this type of tumor. In the effort to discover new agents and combinations that may augment the therapeutic arsenal available for the management of this cancer, early phase clinical trials have been performed using ixabepilone with promising results. Targeting the microtubule system with certain taxanes in the management of pancreatic adenocarcinoma has been validated; ixabepilone also targets the microtubule system, interfering with it in an alternate manner from the taxane mechanism. Ixabepilone has demonstrated activity in cancers that have become taxane-resistant as well as those that never had any demonstrable taxane susceptibility. The available data for the use of ixabepilone in the management of pancreatic adenocarcinoma are limited but promising. Single-arm studies have demonstrated both clinical efficacy and tolerable toxicity for the use of ixabepilone as monotherapy. The trial data available for ixabepilone used as a part of combination therapy are similar: it has been paired with chemotherapy (carboplatin, irinotecan) and biologic therapy (dasatinib, sunitinib) at the phase I level to treat solid tumors in general, again with tolerable side effects and a suggestion of benefit. A single phase II study has evaluated combination therapy with ixabepilone in the management of patients with pancreatic cancer, pairing it with cetuximab with clinical benefit. The authors concluded that although these trials are promising with regard to addition of ixabepilone to the slim armamentarium for management of pancreatic cancer, further work still needs to be done.
Yadav et al (2014) noted that triple-negative breast cancer (TNBC) is defined by the lack of immunohistochemical expression of the estrogen and progesterone receptors and human epidermal growth factor receptor 2 (EGFR2). Most TNBC has a basal-like molecular phenotype by gene expression profiling and shares clinical and pathological features with hereditary BRCA1 related breast cancers. These investigators evaluated the activity of available chemotherapy and targeted agents in TNBC. A systematic review of PubMed and conference databases was carried out to identify randomized clinical trials (RCTs) reporting outcomes in women with TNBC treated with chemotherapy and targeted agents. They identified TNBC studies of chemotherapy and targeted agents with different mechanisms of action, including induction of synthetic lethality and inhibition of angiogenesis, growth and survival pathways. Triple-negative breast cancer is sensitive to taxanes and anthracyclins. Platinum agents are effective in TNBC patients with BRCA1 mutation, either alone or in combination with poly adenosine diphosphate polymerase 1 inhibitors. Combinations of ixabepilone and capecitabine have added to PFS without survival benefit in metastatic TNBC. Anti-angiogenic agents, tyrosine kinase inhibitors and EGFR inhibitors in combination with chemotherapy produced only modest gains in PFS and had little impact on survival. Triple-negative breast cancer subgroups responded differentially to specific targeted agents. The authors concluded that in the future, the treatment needs to be tailored for a specific patient, depending on the molecular characteristics of their malignancy. Moreover, they noted that TNBC, being a chemosensitive entity, combination with targeted agents have not produced substantial improvements in outcomes. Appropriate patient selection with rationale combinations of targeted agents is needed for success.
Tredan et al (2014) stated that despite high initial sensitivity to chemotherapy, TNBC is associated with a poor prognosis, highlighting the need for novel therapeutic strategies. In a multi-center, randomized, open-label phase II clinical trial, these researchers evaluated the effectiveness of ixabepilone as monotherapy, and the combination of ixabepilone with cetuximab, as first-line treatment in patients with triple-negative locally advanced non-resectable and/or metastatic breast cancer. Women were randomly assigned to receive either ixabepilone (40 mg/m2) every 21 days (n = 40), or ixabepilone (40 mg/m2) every 21 days with cetuximab (400 mg/m2 loading dose, followed by 250 mg/m2) once-weekly (n = 39). The primary end-point of the trial was to estimate the response rates of ixabepilone monotherapy and ixabepilone with cetuximab combination therapy. Of 79 randomized patients, 77 were treated. Based on an intent-to-treat analysis, an objective response rate of 30 % (95 % CI: 16.6 to 46.5) was observed in the monotherapy arm, and 35.9 % (95 % CI: 21.2 to 52.8) in the combination arm. Median PFS was 4.1 months in both treatment groups. Safety findings were consistent with the known individual toxicity profiles of ixabepilone and cetuximab. Skin and subcutaneous tissue disorders were more common with combination therapy, as were discontinuations because of adverse events. The authors concluded that ixabepilone monotherapy and the ixabepilone and cetuximab combination demonstrated similar levels of clinical activity in first-line treatment of advanced TNBC, with a predictable safety profile. They stated that further investigation of novel therapies for TNBC is needed to improve patient outcomes.
In a phase II clinical trial, Duska et al (2014) determined the activity of ixabepilone as a single-agent as second-line treatment for patients with metastatic uterine leiomyosarcoma who had received taxane based therapy. Eligible women with unresectable uterine leiomyosarcoma progressing after prior cytotoxic therapy containing a taxane were treated with ixabepilone 40 mg/m2 on day one of a 21-day cycle. Patients with prior pelvic radiation were treated without dose reduction. Response Evaluation Criteria in Solid Tumors response was assessed by computed tomography (CT). Twenty-three of 26 women were evaluable (2 wrong histology, 1 never treated) with 2 of 23 receiving 1 cycle of therapy. There were no complete responses (CR) or PR. Stable disease was seen in 4 patients (17.4 %, median of 3.4months). Seventeen patients (73.9 %) had increasing disease (PD) and 2 patients were inevaluable per RECIST. One patient had SD over 6 cycles of treatment. Median PFS for all 23 patients was 1.4 months and OS was 7.0 months. The predominant grade 3 or 4 toxicity was uncomplicated myelosuppression: neutropenia grade 3 (13 %), grade 4 (17 %), and anemia grade 3 (22 %). The authors concluded that ixabepilone as a single agent is not an active second-line therapy for uterine leiomyosarcoma previously treated with a taxane.
Continued use beyond 3 months (12 weeks) is considered medically necessary for persons with stable disease (tumor size within 25 % of baseline). Continued use is considered not medically necessary when there is evidence of disease progression or unacceptable toxicity occurs.
|CPT Codes / HCPCS Codes / ICD-10 Codes
|Information in the [brackets] below has been added for clarification purposes.  Codes requiring a 7th character are represented by "+":
|ICD-10 codes will become effective as of October 1, 2015:
|Other CPT codes related to the CPB:
|Chemotherapy administration, intravenous infusion technique; up to 1 hour, single or initial substance/drug
|each additional hour (List separately in addition to code for primary)
|HCPCS codes covered if selection criteria are met:
|Injection, ixabepilone, 1 mg
|ICD-10 codes covered if selection criteria are met :
|Malignant neoplasm of breast
|ICD-10 codes not covered for indications listed in the CPB (not all inclusive):
|Malignant neoplasm of stomach
|Malignant neoplasm of pancreas
|Malignant neoplasm of bronchus and lung [non small-cell]
|Malignant neoplasm of breast
|Malignant neoplasm of uterus [uterine leiomyosarcoma]
|Malignant neoplasm of ovary
|Malignant neoplasm of prostate
|Malignant neoplasm of kidney and renal pelvis


text:
All I Got Left is My THREAD BOMBS!
View Single Post
July 3 2012, 09:52 PM
Re: All I Got Left is My THREAD BOMBS!
cooleddie74 wrote:
My attitude has always been: if you go to the gym and reap physical health benefits and happiness from it, more power to you. Knock yourself out and have a great time.
But I don't want nor need to hear every detail about it.
You lift weights, run on a treadmill and ride a stationary bike. You're not the Pope.
Wait... WHAT?
...gyms have NO religious component for humans?!? That makes no sense then. Why would humans *pay* to do what would normally considered to be *work*?
...there must be a bacon reward in there somewhere...
View Public Profile
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Very clean and relaxing facility, not easy to find the spa, it is on the lower ground level. The therapists are careful. Would reccomend it and will definitely come back to try other beauty treatments.
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Coca-Cola Bottling Co. Consolidated opens new call center
November 10, 2015
Charlotte-based Coca-Cola Bottling Consolidated's new call center in northeast Charlotte will bring more jobs to the region and add to the company's long history in Charlotte, Gov. Pat McCrory said at a kickoff for the facility on Tuesday.
Red Ventures to double size of Indian Land headquarters
October 28, 2015
S.C. Gov. Nikki Haley is scheduled to attend an event next week at which Red Ventures will announce it is doubling the size of its Indian Land headquarters to almost 600,000 square feet.
Plastics company plans $100M plant in Chester, 300 jobs
October 27, 2015
After a nine-year delay, Poly-America of Grand Prairie, Texas, will put a $100 million facility on the Chester County land the company bought way back in 2006.
Sipping whiskey: Distillery hopes to revive Statesville's unique claim to fame
September 17, 2015
Statesville, the Iredell County city said to have been known as the Distilling Capital of the World before Prohibition, may have another shot at fame.
British company to open plant in Mooresville
August 31, 2015
A British company that provides thermal processing services will open a heat treating facility in Mooresville.
Pineville specialty packaging plant to add 100 employees by year end
August 28, 2015
A British company will add at least 100 employees by the end of 2015 to its Pineville specialty packaging plant to keep up with growth in the business.
Maker of Hoover, Dirt Devil bringing 200 jobs, $5 million investment to Charlotte
August 25, 2015
TTI Floor Care North America plans to hire 200 workers over the next two years as it sets up a marketing and innovation center in Charlotte, Gov. Pat McCrory and economic-development officials announced Tuesday.
Chemical company to bring its headquarters, 120 high-dollar jobs to Charlotte
August 25, 2015
Specialty chemicals firm Albemarle Corp. plans to move its headquarters and 120 jobs to Charlotte.
Charlotte's craft beer scene among nation's fastest growing
August 10, 2015
Charlotte is one of 10 cities nationwide where craft beer continues to gain momentum, according to TheStreet.com.
Red Ventures to hire another 500, grow to 2,800
July 10, 2015
Red Ventures is hiring again, planning to add 500 employees during the next two months.
That would bring total employment to about 2,800 for the Internet marketing company, which is based in Indian Land.


text:
As a taxpayer in Uhrichsville, I personally think that all of the council members and especially the council president should resign. It's a tragedy how they have let the city get in the shape it's in and they've done absolutely nothing to try to make it better. Shame on them.
I'm a bus driver for Tusky Valley Schools and my route runs in Warren, Lawrence and Sandy townships and I just want to thank the hard-working employees there for keeping the roads safe there for my kids.
I thought I had heard it all, but when I read that the Muslims in Detroit were suing McDonald's and won for not preparing their chicken right, I was just aghast.
This is to the person who called Rush Limbaugh a nut case. The real nut cases are you and the guy who sits in the president's seat in the White House.
The basic tenant of the Second Amendment is for the people of the United States to protect themselves from the tyranny of our government. It's not about hunting. The self-protection comes in from the government.
I never thought we'd see the day when the people in Washington, D.C., are against the people instead of for the people. Well, it's here.
Have an opinion? An answering machine is on duty 24 hours a day. Call 330-364-1939 or email email@example.com. Callers should speak clearly and slowly after the beep. Personal attacks, obscenities or intolerant messages are not acceptable.
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text: Hi folks! Seems sbcl's documentation does not work so well with texinfo 5 [0]. Are there plans to get this fixed soonish? I have only the newer version available for building the debian packages and would love to update sbcl in usntable and keep the documentation ;-) Christoph [0] http://paste.faui2k9.de/f/ba5a7caaa8b8ed55ad6f9d5850969f04c5c67bb7efd97fe07d190bca5d964af2 -- 9FED 5C6C E206 B70A 5857 70CA 9655 22B9 D49A E731 Debian Developer | Lisp Hacker | CaCert Assurer


text:
Windows VPS Quick Start Guide
WELCOMEWe have prepared this document to assist you to set up your VPS in a hassle-free way. This document is speacially prepared for all non-technical customers who are willing to use VPS service but unable to do so because of the lack of technical knowledge. This document will cover all the aspects of configuring & managing Windows VPS. Apart from this, our support team is always here to assist you anytime for any questions. You can either refer to our Knowledgebase or contact us via 24 X 7 live chat support.
As you may be knowing, that setting up and managing a VPS is not a simple job. You need thorough technical knowledge to take care of Windows VPS technical issues. If you have chosen to avail our Fully Managed VPS services, our technical team will troubleshoot any technical issue that may arise and that are covered in the fully managed support scope. However, if you have chosen to go for Unmanaged VPS services then this guide will be helpful to manage those issues.
Windows VPS can be easily managed if you've a control panel like WebsitePanel or Plesk. We are offering WebsitePanel and Plesk both control panels with Windows VPS plans.
Once your VPS is set up, you will receive a welcome email having all the required instructions to log in to your VPS, control panel, database server, etc. Let us see the flow for Windows VPS ...
Table of Contents
- VPS Management Portal
- RDP Management
- Windows VPS Management with WebsitePanel
- Domain and Website Management
- FTP Account Management
- Database Management
- MSSQL Server
- MySQL Server
- DNS (Nameservers) Management
- Using Registrar's Nameservers
- Using VPS'/Custom Nameservers
- Manage Windows VPS without WebsitePanel
- Manage Website
- FTP Management
- DNS Management
- Setup rDNS
- Email Management
- Network Wide Blocked Ports
- Web Platform Installer
(1) VPS Management Portal
As soon as you receive VPS login details, we request you to Verify the VPS login details. If any of the login details are missing or if they do not work, you can submit a support ticket. After login details verification, the next step will be to verify VPS resources. VPS resources can be verified in 2 ways:
- From VPS Management Portal
- From VPS itself (via Remote Desktop)
In order to login to VPS management portal, refer to our step by step guidelines. VPS Management portal allows you to verify and monitor VPS resources such as vCPU, RAM and Hard disk space. Apart from that, you can also perform the following tasks:
- Reboot/Pause your VPS
- Check VPS configurations and Audit logs
You can also verify VPS resources (vCPU, RAM and Hard disk space) from Remote Desktop itself. For more detailed steps, please refer to our step by step guidelines.
(2) RDP Management
Once you finish the VPS resources verification, let's see how can we Remote Desktop to VPS from various Operating systesms. You can refer to our guidelines for the operating systems like Windows, Mac and Linux. If you are using any other OS other than these then you can submit a support ticket from your billing area to our Technical team.
(3) Windows VPS Management with WebsitePanel
Rather than managing a Windows VPS through Remote Desktop, we recommend our customers to do so using WebsitePanel. WebsitePanel is a free and easy to use web based control panel. We install and configure WebsitePanel at free of cost, if you have chosen it while placing the VPS order. WebsitePanel allows you to manage domains, websites, FTP accounts, Email accounts, databases, etc. from single portal. In order to login to WebsitePanel, please refer to our step by step guidelines.
Once you logged into WebsitePanel, follow our Master Guideline. It is specially prepared for the WebsitePanel beginners. This single guideline teaches you how to add customers, their hosting plans, domains, websites, FTP accounts, MySQL/MSSQL databases, Email accounts, etc..
There is no need to follow this Master guideline everytime when you would like to manage all these services individually. For Example, if you just want to add a domain/website, you do not need to follow each steps mentioned in this Master Guideline. Let's understand the entire flow to manage individual service with in a precised way:
(3.1) Domain and Website Management
You will need to follow the steps mentioned in following video tutorials to add a domain and website under a customer:
(3.2) FTP Account Management
You will need to follow the steps mentioned in following video tutorial to create an FTP account:
The next step will be uploading web contents on server. In order to upload web contents through FTP, refer to our FTP client tutorials. This set of articles provide you step by step guidance on how to connect with FTP server through most popular FTP client applications like FileZilla. You just need to choose your desired FTP client and proceed accordingly.
(3.3) Database Management
(3.3.1) MSSQL Server
Once your web contents are uploaded to Web server, the next step would be uploading/restoring the database. In case of MSSQL database, you just need to upload the database backup copy (in .BAK format only) in webspace through FTP and restore from the backup through WebsitePanel. In case if you have large size of database backup and WebsitePanel won't allow you to restore then you can do it manually from SQL Server Management Studio.
By default, MSSQL server is configured on port 1533. You can remotely connect to your MSSQL server using SQL Server Management Studio. In order to connect to MSSQL server through SQL Server Management Studio, refer to our guidelines. Once your MSSQL database has been restored, you can modify the website connection string accordingly.
(3.3.2) MySQL ServerWebsitePanel allows you to create/remove MySQL databases. You can follow the steps mentioned here to create MySQL databases from WebsitePanel. Additionally, MySQL server can be managed through web based Interface called "phpMyAdmin". In order to connect to MySQL server through phpMyAdmin, refer to these steps.
(4) DNS (Nameservers) Management
So far, we belive that you have verified VPS login details, VPS Resources, created domains, websites, databases, etc. from WebsitePanel. Now the little tricky part comes; i.e. DNS Management. DNS management is not a kind of rocket science. It is easy; if you strictly follow its methodology. Since, you have purchased the Windows VPS, the first thing will come into your mind; "How do I point my website to my VPS". Well, there are 2 ways to accomplish it,-
(4.1) Using Registrar's Nameservers
In this case, you will use DNS services of your domain registrar, i.e. DNS Zone of your domain will be created at DNS server of your registrar. You just need to contact your Registrar and tell them to change your domain's A records with your VPS IP address. If you think, you are able to perform this task at your own; you can add following A records at Registrar's control panel:
- www.................A.........................Your_VPS_IP_address
- (blank)..............A.........................Your_VPS_IP_address
- *......................A..........................Your_VPS_IP_address
- mail..................A.........................Your_VPS_IP_address
- MX...............................................mail.yourdomain.com
Once these records are added, it will take 24 to 48 hours in global propagation and your website will start pointing to your VPS. You will have to repeat this exercise everytime you host new website in your VPS.
(4.2) Using VPS'/Custom Nameservers
This method is little tricky, but you will have to perform it only once. Let's go through it step by step. Suppose, you have registered a domain "yourdomain.com" and you wish to point this domain to your VPS and set the nameservers as below:
- ns1.yourdomain.com
- ns2.yourdomain.com
(4.2.1) Registering the private nameservers at your RegistrarLogin at your domain control panel (Registrar's control panel) and register above child/private/custom nameservers. Please refer to our tutorial series to register the private nameservers at various registrars. If you find Registrar's control panel's UI different than shown in video tutorials, you can always contact your Registrar to register custom nameservers for you.
(4.2.2) Create nameservers at WebsitePanelIf you have provided the nameservers information at the time of sign up as ns1.yourdomain.com and ns2.yourdomain.com, then you do not need to follow the below mentioned steps:
- Login to WebsitePanel
- Go to Configuration → Servers
- Click on your server name
- Click on DNS
- Under Nameservers, enter your primary and secondary nameservers and click on Update button
(4.2.3) Host Domain/Website at WebsitePanelRefer section 3.1 to host a domain and website yourdomain.com through WebsitePanel.
(4.2.4) Set private nameservers for your domainNow, login to Registrar's control panel and set newely registered namservers. You can also contact Registrar support to set nameservers for you. Once custom nameservers are registered, you can set them for all your domains you host in VPS.
You can verify whether you have pointed your webiste correctly to your VPS or not through online DNS lookup tools like INTODNS.COM. If everything goes well, your website will start pointing to your VPS within 24 to 48 hours after setting up the nameservers.
(5) Manage Windows VPS without WebsitePanel
As mentioned above, to manage Windows VPS, we always recommend WebsitePanel as it facilitates you to manage all VPS services under one login. In case, you have not opted for WebsitePanel. you will have to refer the following guide:
(5.1) Manage websites
In the absence of WebsitePanel, you need to create a Website from IIS itself. Please refer to these detailed steps for manual website creation.
(5.2) FTP Management
Similarly, you need to create an FTP website in IIS by following steps mentioned here. Once you create FTP accounts, go to section 3.2 to upload web content on server.
(5.3) DNS Management
(5.3.1) Register the custom nameserver at Registrar as shown in section 4.2.1
(5.3.2) Create forward lookup zone from DNS Server
- Click Start, point to Administrative Tools, and then click DNS
- Click the DNS Server object for your server in the left pane of the console, and then expand the server object to expand the tree
- Right-click Forward Lookup Zones, and then click New Zone. The New Zone Wizard starts. Click Next to continue
- Click Primary zone to create a master copy of the new zone. Click Next
- In the Name box, type the name of the zone (for example, type _tcp.example.com, and then click Next
- On the Zone File page, accept the default file name for the new zone file, and then click Next
- Click Next
- Click Finish
(5.3.3) Add Host Records to Forward Lookup Zone and set nameservers
- Right-click on your forward zone, click on New Host
- Type the host name of your DNS server and the IP address. In this example, "ns1" will be the hostname and your VPS IP address will be the IP address. Make sure you select "A" record from the record type
- Click Done
- Repeat 1 to 3 steps to create a second nameserver record "ns2"
- Set newely created nameservers to domain at your Registrar
Please refer to the URL to add DNS records in created DNS Zone. Once you register the child nameservers (private nameservers), you can go ahead and use them for any domains you host on your VPS. Nameservers may take 24 to 48 hours to propagate across the globe.
(6) Setup rDNSIf you want to set rDNS for your VPS IP address, kindly submit a support ticket from your billing area. You will have to provide the following information in the ticket:
- IP address
- Hostname
(7) Email Management
If you have selected the SmarterMail option during signup, SmarterMail Professional latest version (currently it is 13.x) will be installed and configured on your VPS. You can manage SmarterMail email accounts from WebsitePanel. You can also administrate the SmarterMail server through web based interface. By default, SmarterMail webmail interface is configured on port 9998. You can access your mail interface using http://Your_VPS_IP_Address:9998. In addition to this, you can refer to our complete set of SmarterMail tutorials from here. If you have not opted for WebsitePanel, you will have to manage SmarterMail from its web interface.
(8) Network Wide Blocked Ports
We block the inbound traffic network wide on the following ports:
- 135 - 139 (NetBIOS)
- 445 (NetBIOS)
- 497 (Backup Software)
- 1433 - 1434 (SQL Server)
- 1025 (MS Scheduled Task Endpoint)
If you have a specific requirement to use above ports, please open a ticket and we will be able to allow the traffic you require.
(9) Web Platform Installer
The Microsoft Web Platform Installer (Web PI) is a free tool that offers the latest components of the Microsoft Web Platform, including Internet Information Services (IIS), SQL Server Express, .NET Framework and Visual Web Developer easily.
The Web PI also makes it easy to install and run the most popular free web applications for blogging, content management and more with the built-in Windows Web Application Gallery. You can refer to the URL for more details about Web Platform Installer and download information.
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