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Star Ship Polaris
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March 24 2010, 07:17 AM
Location: Portland, OR
Re: Star Ship Polaris
Vektor wrote:
Albertese wrote:
Cool. I'll have to see if I can get similar results in Photoshop, seeing as how I don't have Corel. I'm using a WACOM Intuos, which is pretty simple. What do you like about the Cintiq? Are there any fancy features that sets it apart?
Well, the Cintiq is not just a pen tablet, its also a graphic display so youre working directly on-screen. I havent used the Intuos but I have used the Bamboo series and they work well, but not having that disconnect between my hand and my eye makes all the difference to me.
Well, there you go! That's pretty nifty. I can't hardly "draw" with my pen and tablet. I generally sketch with a real pencil and usually ink it and then scan it to refine digitally. I can see how how having the image right there to draw on would make digital art that much easier. Hmm, I'll have to save my pennies though. At about $1,000 give or take, I think it'l have to stay on the wish-list for a while...
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Court Broadens Sources' Defense against Press Breaking Anonymity Pledge Can Be Breach of Contract; Fabricating Quotes Grounds for Libel
Marshall Ingwerson, writer of The Christian Science Monitor, The Christian Science Monitor
IN a matter of days, the United States Supreme Court has issued two separate rulings that open up the press to lawsuits from news sources.
The upshot is that newspapers and magazines could conceivably report fewer nuggets of sensitive or controversial news, but the news that readers lose will also be some of the least reliable.
The Supreme Court ruled June 24 that a news source who gave information to two Minnesota newspapers on the condition of anonymity could sue them for breaking that promise.
The ruling came on the heels of a decision June 20 that interview subjects could hold a journalist liable for fabricating remarks presented inside quotation marks.
Many journalists admit to mixed feelings over the decisions.
They don't like to be told how to treat their sources by the courts, and many who found no cause for concern in the first decision last week see a foreboding intrusiveness in both of them together.
Yet the minimum standards of journalistic ethics set by the court, some journalists concede, may benefit press credibility.
"Both cases strike me as having the same common thread," says Scott Armstrong, an investigative reporter formerly with the Washington Post and now teaching at American University. In both cases, he says, the court applies minimum standards of reporting.
The practice of quoting people while keeping their identities confidential is a widespread daily routine among reporters. For newspapers to break these agreements is relatively rare. Reporters, in fact, are occasionally jailed for refusing to divulge sources.
In the Minnesota case, a public relations man working for one political candidate in 1982 gave newspaper reporters potentially damaging information about another. Editors then decided to publish his name as the source. He was fired by his advertising agency.
He sued for breach of an implied contract to keep his name confidential, and he won. The Minnesota Supreme Court overturned the victory. The US Supreme Court now returns the case to the state court with the judgment that breach of contract is a legitimate grounds for the suit.
The court's new decision adds the threat of expensive lawsuits and monetary damages to the ethical commitment to protect sources. The result could mean that editors will press reporters to cut down on using anonymous sources, says Bill Kovach, curator of the Nieman Foundation at Harvard University. …

subset: commoncrawl


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Student organizations donated 1,274 non-perishable items to support Field & Fork pantry! Thank you for the support!
Follow us on social media to get the latest updates on your favorite student organizations and campus events! Whether we're snapping live from a talent show or reminding you about officer training, you'll get the best info from SAI_UF!
Reginald Lane received the James E. Scott Fellowship, Solange Douglas received a Research Award, and James Tyger received the Art Sandeen Award.
Gator Connect is the Student Organization Database. Anything student organization related can begin here!
Click here to view student organization events that are happening on campus.
Want to get involved but don't know where to start? Student Activities and Involvement is here to help you!
Make it Reitz
U Matter We Care
Medical Amnesty Policy
Student Government
Stop Bias
SAI wants to celebrate our wonderful staff for receiving their recent awards. Reginald Lane received the James E. Scott Fellowship, which recognizes his commitment to our students and will allow him to broaden his impact. Solange Douglas received a Research Award for being able to apply the data she collected to improving the quality of our advisor trainings and communication. James Tyger received the Art Sandeen Award which is given annually to a UF Division of Student Affairs staff member with less than three years full-time student affairs experience who exemplifies the values that Dr. Sandeen modeled: dedication to the profession, a love for students, commitment to mentoring others in the profession, and a commitment to academic excellence. Thank you all and congratulations!
As part of the Make it Reitz Project, the Student Activities and Involvement offices have moved to temporary office spaces. For general questions visit the SAI front desks in the Game Room on the ground floor of the J. Wayne Reitz Union.
SAI Administrative staff offices are located on the second floor Reitz Union in room 2330.
Student Government offices are located on the second floor Reitz Union in rooms 2360 and 2365.
Sorority and Fraternity Affairs offices are located on the second floor Reitz Union in room 2335.
Student Organization and Campus Events offices are located on the ground floor of the Reitz Union in the Game Room.
We will move to permanent locations on the third floor in spring of 2016.
Please email: firstname.lastname@example.com or call: (352) 392-1671 with any questions.
There are nineteen outdoor recreation trips already planned for fall 2015. Students will register online with RSConnect beginning Summer B. Visit recsports.ufl.edu for more details on the move. Please direct questions to email@example.com.
Student Activities and Involvement is pleased to present its Annual Report for 2012-2013 which showcases our achievements and successes for the year. It is available for download here.


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on most orders over $49*
Contemporary 67" Icicle Floor Lamp
5 stars
We are using this as our primary living room light. It provides a great amount of light when not dimmed. Product construction was not quite as easy as I had hoped, but well worth the slight struggle- Heather in denver, CO
Belle 3 Light Arched Floor Lamp
5 stars
Great lamp! The three lanterns provide a lot of light. As others have noted, the lamp shades are paper and therefore quite delicate. We were careful when assembling and had no issues, but we did have- Cathy in New York, NY
Hudson 61" Floor Lamp
4 stars
I love the lamp, the only issue is the shade is not made all that well.- Jennifer in Port Saint Lucie, FL
Hayworth Floor Lamp
5 stars
easy to assemble- Jay in Goleta, CA
Plimpton Arc Floor Lamp
5 stars
The lamp is exactly as described . Great quality. Would buy again Pros: Easy to put together, solid structure, and look amazing Cons: None- Navid in Lenexa, KS
Hollywood Floor Lamp
5 stars
Love the tap touch control of this lamp!- Brenda in Metairie, LA
Sedona 1 Light Floor Lamp
5 stars
Love the light and perfect square size. Easy to assemble.- Anthony in MA
Trinity 3 Light Arc Floor Lamp
5 stars
Good as description- Changran in Portage, MI
Trinity Arc Floor Lamp
5 stars
Got this in post as expected, looks same as seen n the picture. Pros: size and color- SUDHEER in MARIETTA, GA
Stoddard 52" Floor Lamp
5 stars
Perfect Color, brown that blends into my decor. It doesn't stand out and gives plenty of light for reading and not disturbing my husband while he sleeps.- Debra in Westmont, IL
Mercur Floor Lamp
4 stars
exactly as pictured. I have a philips hue light in here and the colors look beautiful from inside the lamp Pros: as pictured, very contemporary Cons: very wide base, takes up a lot of room- Nancy in alexandria, VA
Henry Arched Floor Lamp
5 stars
I've had this lamp for quite awhile now. It has clean lines with a graceful arch, as pictured. the lamp shade texture is lovely. No issues, I highly recommend. Pros: easy assembly, lovely- Mani in Pinole, CA
LuminArt Celestial Floor Lamp
5 stars
My 13 yr old loves the light and settings. The yello chair is fun to look at but not too comfortable. My feet don't even touch th floor.- CK in Omaha, NE
Harmony Floor Lamp
4 stars
Beautiful lamp with a warm soft lumen. Downside is the lamp shade. There is a visible seem on one side where they glued it to the lampshade. I keep the lamp with the seem side facing in towards a- Willina in Washington, DC
Titan 1 Light Floor Lamp
4 stars
I love this lamp! It went well with out furniture in the living room. Just had to buy another lamp because it isn't bright enough- Loumania in walnut creek, CA
Bellows 3 Light Floor Lamp
5 stars
I love the two light settings and it definitely is very modern. A great buy!- Ricky in Los Angeles
Felt Floor Lamp
5 stars
Cool lamp. If you want something different and forward this might be it.- Ernesto in MIAMI LAKES, FL
Odyssey Floor Lamp
5 stars
I received this beautiful floor lamp last week, my husband and I loved the lamp. Very bright and modern looking. Very easy to assemble.- Hong in Gainesville, FL
Huntington Floor Lamp
5 stars
Easy to assemble. I have purchased three of them and they look great!- angeliki in NJ
Bordeaux 1 Light Arc Floor Lamp
4 stars
I like the lamp very much. It came together fairly easily despite the small lettering on the diagram and the directions which were written by a non-native English speaker. I intended to place my lamp- Lisa in Spokane, WA


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>Car sales slump as America gets on its bike
>By Harry Mount in New York
>(Filed: 04/10/2005)
>Lance Armstrong, rising petrol prices and America's love affair with the body beautiful have helped to launch >a boom in bicycle sales while the number of cars sold has slumped.
>Sales of speciality bicycles have soared by 10 per cent so far this year while car sales are down by 9.5 per >cent in the same period.
Looks like the price of oil has taken its toll
on car sales to a certain extent.
Ned Goudy


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The New York Times report, "Trial on Guatemalan Civil War Carnage Leaves Out U.S. Role," raises at least one obvious question: How much has U.S. coverage of the Ríos Montt trial talked about U.S. support for genocide?
Bum Rap: The U.S. Role in Guatemalan Genocide
NYT Reports Honduras (Opponent Opinions) From Afar
Looking at a June 28 New York Times report that the "Honduran President Is Ousted in Coup," A Tiny Revolution blogger Bernard Chazelle (6/28/09) writes that "from the byline alone, you know this is going to be good": "Elisabeth Malkin, in Mexico City, with reporting by Simon Romero from Caracas." To Chazelle this all "makes perfect sense since, as we all know, Mexico City and Caracas are the two major cities in Honduras. (Too bad they had no reporter in Bangkok. I hope the Pulitzer committee doesn't notice.)" Moving on to the piece's actual content [since altered by the Times], […]


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About This Activity
When Elvis-like rock & roll star, Conrad Birdie, is about to be inducted into the Army, the teen nation is united by a national publicity contest where Birdie will bid a typical American teenaged girl goodbye with an All American kiss live on the "Ed Sullivan Show". A satire done with the fondest affection, Chanhassen Dinner Theater breathes new life into this Broadway Tony Award winning musical of the 1960's. Bye Bye Birdie and it's theme of parents and teens still resonates with today's audiences.


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Blowfish Sushi to Die For Map
2170 Bryant St. (20th St.)
415-285-3848 | Make Restaurant Reservations | Order Now! | Menu
The location of Blowfish Sushi to Die For is marked on the map below with a green arrow. Click on it to get directions if you don't see a pop-up. Enjoy your meal at Blowfish Sushi to Die For!
Check out the 2015 edition of GAYOT's Annual Restaurant Issue, which features the Top 40 Restaurants in the US and more.


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like us!
recent blog posts
- It's Time to Be Kind to Family Caregivers
- The Truth About Your Postmenopausal Body
- Mammogram Guidelines Change—and Differ—Once Again
- Celebrating 60 in Italy
- My Foodie Retirement Project: "1,000 Foods to Eat Before You Die"
- 7 Ways To Fall Off the Exercise Wagon
- Do You Want To Be Happier in 2016? "Choices" Can Help!
- The Awesome Pregnancy Perk a Start-Up Company Offers
- 5 Ways to Beat the "I Don't Have Time" Trap
- Do You Have to Give Up Your High Heels?
Tuesday, Apr 07th 2009
Tick-Tock Goes the (Biological) Clock. (Listen up, Men!)
Here's some news that may make all of us women feel not so alone in hearing that deafening clicking of the biological clock. That clock is no longer gender-specific.
We used to think it was just us, right? That our eggs were aging along with the rest of us and that men were off the hook and could produce forever? (Long live the sperm!)
A new study out of Australia proves otherwise. Researchers at the University of Queensland found that children born to older men faced higher risks of lower I.Qs, aside from lower scores on tests involving concentration, memory, reasoning and reading skills through the age of 7.
Other studies have linked things like increased risk of schizophrenia and bipolar disorder and even autism to children whose fathers were older, too.
I can't help but feel a little relief. I mean, it's nice to know that finally the burden is not just on US. And that older single men, who so frequently find a certain thrill of dating much-younger women, may no longer be seen as desirable second-family daddies, since the secret is now out that their sperm is just as old as, well, they are. (Could this be the beginning of more available men for women in their 50s? Maybe the playing field will narrow, if not equalize, for those 50-something women left behind?)
And then there's this: women have borne (pardon the pun here) the burden of feeling the rush - and I don't mean in a good way - to get motherhood "taken care of" sooner than later, lest they risk increased odds of things like Down syndrome and lower birth weight. With this news, it seems that men might have to let go of the notion that they have all the time in the world.
Apr 07, 2009 21:Apr 9 | Anonymous said
I love this article. It's good to know that when m...I love this article. It's good to know that when men age they are no longer as virile as they think they are. I only hope that younger woman get hip to this.


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Except for Fornication (http://energionpubs.com/
In commenting on his motivation for writing this study, Dr. Parunak notes: "The tragedy of divorce and remarriage touches everybody in today's culture. My brothers and sisters are hurting. I see them acting in ways that will make them unhappy, and ultimately bring God's chastisement on them. How can I stay silent? So the fear of God, and my love for his people, have led me to study this issue, and present it in a way that I hope will be clear and helpful to you."
Review copies are available from the publisher. The book will be available from major online retailers or from the publisher's direct sale site, EnergionDirect.com.
Dr. H. Van Dyke Parunak is currently the Chief Scientist at Vector Research Center with Jacobs Engineering Group, Michigan. He has an AB in Physics from Princeton University, an MS in Computer and Communication Sciences from the University of Michigan, a ThM in Old Testament from Dallas Theological Seminary and his PhD in Near Eastern Languages and Civilizations from Harvard University. Dr. Parunak has over 100 publications in journals and highly-refereed conferences.
# # #
Energion Publications publishes challenging, educational, and spiritually uplifting material for the broad Christian center. We look for books that present strong views presented in such a way as to invite dialog.


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John J Yust Photographer
Lacey Allen1Model Female Brookhaven, Pennsylvania, US
Mayhem # 2295180
About MeHi, I'm Lacey, and I would love to gain more exposure via this site, and network in order to gain more print work. I've spent a couple years as a promotional model for a liquor company. I have also worked trade show events and been featured in a health magazine. I am best suited for beauty, hair/makeup, and product modeling, and also do well with a 50's pin-up look. I have a navel and nose piercing, either of which can be removed if the job/shoot warrants. I do not have any tattoos. I love modeling and meeting new people. I'm reliable, punctual, willing to work hard, and an all around nice person.
Please contact me to discuss a reasonable rate. Unfortunately, I am no longer accepting TFP unless a very special opportunity, as my schedule and finances don't allow for this.
**I will not shoot nudes or implied.
Thanks for checking out my profile!
Have you worked with Lacey Allen1? Add Credits for Lacey Allen1! >>
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As a member of USA-People-Search.com, you now have privileged access to an extensive database of record for any Oliva Quezada you need to locate. You can browse through a long list of personal details like phone numbers, past addresses, and email addresses. Go through all the responses carefully and choose the right Oliva Quezada from CO.
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Intense research is being conducted in many areas related to ALS, from basic science seeking the roots of the disease, to therapy development to find effective treatments.
Since inception, MDA has dedicated over $344 million to ALS research and health care services. In the past five years alone, MDA has spent over $46 million toward ALS research.
Research into familial (running in families) forms of the disease also may have relevance for sporadic (nonfamilial) forms, as all ALS cases — regardless of the form — may present and develop along similar lines.
Many other medications and treatments are being tested for potential benefits in ALS. See Clinical Trials [1] for details.
This section offers an overview and links to more information about ALS research targets and strategies, and research administration in ALS.
Additionally, there are many strategies currently in the pipeline for ALS drug development [2].
Research strategies discussed in this section:
Astrocytes [3]
Misfolded proteins [7]
While some research teams have focused their attention on microglia, the nervous system's immune cells, others have focused more on astrocytes, a type of non-nerve glial cell that normally provides support to motor neurons and other cells in the nervous system. Among their roles is clearing away a potentially toxic compound called glutamate from the area around nerve cells. ALS patients have been shown to have dysfunctional clearing of glutamate which is likely due to defects within astrocytes.
Investigators have shown that treating astrocytes alone [10] can delay disease onset and extend survival in mice with a disease resembling ALS caused by mutations in the SOD1 gene.
In 2011, researchers showed that toxicity from astrocytes [11] causes nerve cells to degenerate in new models for both inherited and noninherited forms of ALS.
Study results from two experiments reported in 2013 showed that astrocyte-associated harm to motor neurons may differ [12] depending not only on whether the astrocytes carry a mutation, but on which mutation they carry as well.
Currently, there are many laboratories working to understand how astrocytes become dysfunctional in ALS and develop therapies targeting astrocytes for ALS patients.
Back to top [13]
Many genes, when mutated, can cause familial ALS. Among them are the SOD1 gene, the TDP43 gene and the FUS gene [14]. In 2011, a specific mutation in the C9ORF72 gene [15] was found to be the most common genetic cause of the disease identified so far. Defects in the C9ORF72 gene were also shown to cause another disease called frontotemporal dementia (FTD). Some patients with the gene defect develop ALS, some develop FTD, and some patients develop symptoms of both diseases. (See Causes/Inheritance [16].) Other genes shown to contribute to rare forms of ALS include ubiquilin 2, profilin 1, valosin-containing protein, alsin, senataxin, angiogenin, and optineurin. If someone with an ALS-causing gene mutation is the first in the family to show the disease, the disorder is classified as sporadic, since there is no family history. (This can happen when, for example, a parent carrying the ALS-causing mutation passes away of other causes before ALS develops but not before passing the mutation along to his or her children.)
However, research on the genetic factors that contribute to ALS, without necessarily causing it directly, is of great interest. Scientists suspect that a number of gene variants — probably in combination with other unknown factors — may increase susceptibility to sporadic ALS.
Several large gene association studies have been done comparing the DNA of people with and without ALS in hopes of uncovering genetic differences. These studies have pointed toward potential genetic targets for ALS research. For example, a large, multinational study to identify genetic risk factors associated with ALS found two DNA sequences [17] on chromosomes 9 and one on chromosome 19 that are significantly different in people with and without the disease and may contribute to its development.
When scientists studied DNA from 915 people with ALS and 980 without the disease, they found expanded ataxin 2 genes in 43 (4.7 percent) of those with ALS and only 14 (1.4 percent) of those without it. They concluded that ataxin 2 expansions [18] are significantly correlated with increased risk for developing ALS. Expanded ataxin 2 protein molecules appear to have toxic interactions with TDP43, another protein implicated in ALS, and blocking ataxin 2 interactions with TDP43 could become a new therapeutic avenue.
There are several approaches in development to treat genetic versions of ALS including familial ALS caused by SOD1 mutations. The strategy involves development of a drug called an antisense oligonucleotide which is able to block defective SOD1. This approach may also be useful for other types of ALS caused by different genes.
Back to top [13]
In ALS, there is some evidence that excess amounts of the neurotransmitter glutamate accumulate in the spaces around a nerve cell after it has completed its signaling function, causing problems for nerve cells in the vicinity.
Normally, glutamate — a chemical transmitter of signals between nerve cells — is released by a sending neuron and docks on a receiving neuron. Once docked, it is quickly cleared away by glutamate transporter proteins, which are produced by neighboring cells in the nervous system called astrocytes. In ALS, something may go wrong with this glutamate clearance system. Some studies have suggested that, in ALS, a protein called EAAT2 [19] may not be as efficient at clearing glutamate away from nerve cells as it should be. Other studies have suggested that a glutamate receptor, a docking site on the surface of motor neurons that receives glutamate, may be excessively permeable in this disease.
A drug specifically approved for the treatment of ALS by the U.S. Food and Drug Administration (FDA) is riluzole (Rilutek) [20], which is believed to interfere with the action of glutamate.
Back to top [13]
There is a growing body of evidence that malfunction of the immune system is at least part of the ALS disease process. Research conducted at the ALS Therapy Development Institute (ALS TDI) [21] and other labs has identified abnormal immune system overactivity in animal models of the disease, and ALS TDI investigators have observed it in blood samples from people with ALS.
It had been thought that motor neurons died alone in ALS. But, today, there is evidence that immune system cells in the nervous system called [22] microglia are probably involved in their demise.
Blocking parts of the immune system [23] is a strategy being pursued by ALS TDI researchers at ALS TDI. In 2011, the nonprofit biotech announced it would pursue testing experimental compounds in ALS mice that disrupt parts of the immune system. One, CDP7657 [24], is an antibody fragment that inhibits the immune response by targeting a protein called CD40L. In 2013, ALS TDI launched a phase 2 trial of Gilenya (TDI 132 [25], fingolimod) in ALS. Gilenya dampens the immune response and is approved by the FDA for the treatment of multiple sclerosis.
In addition, scientists at Neuraltus Pharmaceuticals [26] are working on an experimental drug called [27] NP001, which is designed to switch immune system cells from a damaging to a protective mode of action. In 2012, Neuraltus released the results from its phase 2 clinical trial in ALS patients that showed NP001 was safe and well-tolerated. Based on these results, the company is currently planning on taking the drug forward in a phase 3 trial.
Back to top [13]
Cellular proteins normally fold only in certain ways shortly after they're produced. When folding goes wrong, the result may be a highly toxic protein. In 2010, researchers found that misfolded SOD1 protein, unaccompanied by an SOD1 gene mutation, could underlie at least some cases of sporadic ALS [28].
Other proteins besides SOD1 may misfold and contribute to the disease as well. For example, the TDP43 and FUS proteins appear to misfold and form clumps [29] (aggregate) in ALS-affected motor neurons even when the genes for these proteins are normal.
Normally, proteins called chaperones help coax other proteins to fold into the correct shape. Therefore, some scientists are working on increasing levels of these chaperone proteins. An experimental drug called arimoclomol is being tried in SOD1-related familial ALS [30] with this mechanism in mind. Currently, arimoclomol is being tested in a phase 2-3 clinical trial in familial ALS patients harboring defects in the SOD1 gene.
Another approach to targeting misfolded SOD1 is a type of molecule called an antisense oligonucleotide, which keeps toxic, misfolded SOD1 from being made. In 2012, the antisense-based drug ISIS-SOD1-Rx was found to be safe and well-tolerated [31] in people with SOD1-related familial ALS in a phase 1 clinical trial. The drug was developed by Isis Pharmaceuticals [32] with support from MDA. Work is underway to optimize the antisense oligonucleotide prior to further testing in ALS patients.
Back to top [13]
In ALS, the cellular "energy factories" called mitochondria malfunction, although it isn't clear exactly where in the chain of events of the ALS disease process this malfunction occurs.
When mitochondria malfunction, they may fail to produce the needed energy for cells, and they may leak toxic substances called reactive oxygen species, subjecting cells to a kind of poisoning known as oxidative stress [33].
Unfortunately, coenzyme Q10 [34], which combats oxidative stress, was not found to be helpful in people with ALS, even at high doses. (Coenzyme Q10 is an antioxidant, which is a substance that helps clean up free radicals.)
MDA-supported researchers continue to study mitochondrial dysfunction in ALS [35], with an eye to determining whether it's a cause or a consequence of motor neuron loss and whether restoring mitochondrial function can alter the ALS disease course.
Several pharmaceutical companies are investigating antioxidants such as creatine and tamoxifen as possible protectants against cell damage caused by ALS. Other companies are testing their own proprietary antioxidants for efficacy in ALS. The most advanced trials of such compounds to date were phase 2 trials showing potential benefits when these compounds were tested in combination.
Back to top [13]
Stem cells can be thought of as cells that are in the very early stages of development, before they have become specialized (differentiated) to perform specific roles in tissues. They may be precursors to a specific cell types (such as muscle or nerve cells), or they may still retain pluripotency — the ability to develop into any of a number of different cell types.
In ALS, disease-affected stem cells [36] are being used as models in which to study disease processes and screen potential therapies. For example, in 2011, researchers created a model of a type of ALS [37] caused by mutations in the VAPB gene by causing skin cells from people with this form of the disease to revert to stem cells and then growing them in laboratory dishes.
Stem cells also are in development as cell-transplantation therapies. Theoretically, stem cells could be used to replace ALS-affected motor neurons; replace other types of cells, such as astrocytes; or release supportive proteins to help ailing nerve cells.
Early in 2012, the Israeli company BrainStorm Cell Therapeutics [38] announced that its NurOwn stem cell technology appears safe and appears to have improved breathing, swallowing and muscle strength [39] in four people with early-stage ALS, in a trial in Israel. In early 2013, BrainStorm, which plans to test its NurOwn stem cell technology [40] in a trial in the United States in people with ALS, has advanced its phase 1-2 safety trial of adult stem cells to a phase 2a dose-escalating trial [41].
Another biotechnology company, Neuralstem [42] reported in 2012 that its spinal cord stem cells, and the surgical technique used to transplant them, proved to be safe and well-tolerated [43] in a phase 1 clinical trial in 12 people with ALS. This first U.S.-based trial of neural stem cells in ALS opened at the MDA/ALS Center at Emory University in January 2010. In 2014, Neuralstem announced topline results from their Phase 2 dose-escalation clinical trial [44] which proved the cells were safe and that some of the patients may have responded to the therapy.
In addition to BrainStorm Cell Therapeutics and Neuralstem, another biotechnology company called Q Therapeutics announced that they have received approval by the FDA [45] to test their unique stem cells in ALS patients. The stem cells are called glial-restricted progenitor cells and these cells have shown promise in slowing the disease progression in rodent models of ALS.
Many companies and institutions outside the United States (and a few inside) falsely advertise that they can cure ALS with stem cells [46]. So far, there are no stem-cell-based treatments for ALS that are known to be effective at slowing ALS, although Neuralstem's technology appears to be safe so far. Some companies may not even be injecting stem cells. Other may be using stem cells that are too undifferentiated and can be dangerous, while others may be using cells that are too differentiated and are no longer able to join existing tissues. Bottom line: Advertised stem cell therapies should be approached with great caution.
Back to top [13]
In 2008, MDA established a nationwide consortium of five MDA-supported ALS centers [49] for collaboration on clinical trials in ALS. The centers are located in Atlanta, Boston, Houston, New York and San Francisco.
In early 2013, MDA launched a neuromuscular disease registry [50] through its national network of clinics. Through the registry, MDA aims to improve survival and quality of life for people with ALS and other neuromuscular diseases, and to expedite clinical trials and help make them more efficient. The Registry is being piloted at 25 MDA clinics to start; to learn more, check with your local MDA office.
In 2010, the U.S. Centers for Disease Control and Prevention opened the National ALS Registry [51] to compile a large database of information [52] about the incidence and prevalence of ALS, how the disease develops, and what types of treatments and interventions are beneficial. Participation in the registry will help researchers understand whether some types of ALS are caused by environmental hazards, geographic exposures, or occupational risks.
People with ALS and/or their caregivers are encouraged to register at cdc.gov/als [53], where they will be asked to fill out short surveys about their and their families' health, their military background, and their environmental and occupational exposures.
The National ALS Registry also is expanding to include a National ALS Biorepository, with the goal to collect and store specimens from ALS patients for use in research studies. Many researchers have limited access to patient specimens. Access to such specimens is crucial because it allows scientists to validate their findings from the lab in actual human samples taken from patients with ALS. The new biorepository will help make more specimens available to researchers which they can use to accelerate therapy development.
In 2011, the ALS Research Collaboration, a University of Miami-based team dedicated to the study of familial (inherited) ALS, launched the fALS Connect [54] online familial ALS registry. The developers of this registry aim to connect families affected by familial ALS with scientists who study the disease [55], in an effort to accelerate development of treatments and cures. Membership is open to those who have familial ALS and their blood relatives.
[1] http://www.mda.org/disease/amyotrophic-lateral-sclerosis/clinical-trials
[2] http://www.mda.org/research2/state-science/amyotrophic-lateral-sclerosis-als/als-pipeline
[3] http://www.mda.org/book/export/html/349#astrocytes
[4] http://www.mda.org/book/export/html/349#genetic
[5] http://www.mda.org/book/export/html/349#glutamate_inhibition
[6] http://www.mda.org/book/export/html/349#immune_system
[7] http://www.mda.org/book/export/html/349#misfolded_proteins
[8] http://www.mda.org/book/export/html/349#mitochondrial_factors
[9] http://www.mda.org/book/export/html/349#stem_cells
[10] http://alsn.mda.org/article/fixing-motor-neurons-only-path-treating-als
[11] http://alsn.mda.org/news/familial-sporadic-als-linked-via-astrocytes-and-sod1
[12] http://alsn.mda.org/news/als-research-briefs-role-astrocytes-als
[13] http://www.mda.org/book/export/html/349#back_to_top
[14] http://quest.mda.org/news/familial-als-research-update
[15] http://alsn.mda.org/news/c9orf72-mutation-most-common-cause-als-ftd-als-ftd
[16] http://www.mda.org/disease/amyotrophic-lateral-sclerosis/causes-inheritance
[17] http://alsn.mda.org/news/als-research-risk-raisers
[18] http://alsn.mda.org/news/expanded-ataxin-2-genes-major-contributor-als-risk
[19] http://alsn.mda.org/article/studies-strengthen-role-glutamate-abnormal-rna
[20] http://alsn.mda.org/article/predicting-survival-time-als#riluzole
[21] http://www.als.net/
[22] http://alsn.mda.org/article/als-not-just-about-motor-neurons-anymore
[23] http://alsn.mda.org/news/als-research-disconnecting-immune-system
[24] http://alsn.mda.org/news/als-tdi-teams-two-biotechs-develop-therapy
[25] http://alsn.mda.org/news/als-tdi-test-multiple-sclerosis-drug-als
[26] http://www.neuraltus.com/
[27] http://alsn.mda.org/news/flip-switch
[28] http://alsn.mda.org/news/misfolded-sod1-found-sporadic-als-samples
[29] http://alsn.mda.org/article/why-does-als-spread
[30] http://alsn.mda.org/article/als-research-roundup-april-2009#arimoclomol_study
[31] http://alsn.mda.org/news/als-briefs-clinical-trial-updates-2012-alsmnd-symposium#tolerated
[32] http://www.isispharm.com/index.htm
[33] http://quest.mda.org/article/simply-stated-oxidative-stress
[34] http://alsn.mda.org/article/als-research-roundup-june-2008-0#coenzyme
[35] http://alsn.mda.org/article/nine-new-mda-grants-focus-stopping-als#Is_mitochondrial_dysfunction
[36] http://alsn.mda.org/article/covering-broad-canvas-search-als-treatments#stem_cells
[37] http://alsn.mda.org/news/stem-cell-model-creates-als-dish
[38] http://www.brainstorm-cell.com/
[39] http://alsn.mda.org/news/safety-efficacy-in-brainstorm-stem-cell-trial
[40] http://alsn.mda.org/news/brainstorm-hopes-bring-als-stem-cell-trial-us
[41] http://alsn.mda.org/news/als-stem-cell-trial-israel-accelerated
[42] http://www.neuralstem.com/
[43] http://alsn.mda.org/news/neuralstem-phase-1-stem-cell-trial-shows-safety-possible-efficacy
[44] http://alsn.mda.org/news/als-seven-out-15-participants-neuralstem-trial-judged-responders
[45] http://www.mda.org/media/press-releases/fda-approves-investigational-new-drug-application-als-cellular-therapy
[46] http://alsn.mda.org/article/stem-cells-abroad
[47] http://www.mda.org/taxonomy/term/76
[48] http://www.mda.org/disease/lou-gehrig%E2%80%99s-disease-amyotrophic-lateral-sclerosis
[49] http://alsn.mda.org/article/mdas-als-clinical-research-network-streamlining-search-cure
[50] http://quest.mda.org/article/mda-launches-clinical-neuromuscular-disease-registry
[51] https://wwwn.cdc.gov/als/Default.aspx
[52] http://alsn.mda.org/news/national-als-registry-now-open
[53] http://www.cdc.gov/als
[54] https://fals.patientcrossroads.org/
[55] http://alsn.mda.org/news/online-familial-als-registry-opens


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$5,000 minimum balance required to earn advertised Annual Percentage Yield (APY). Substantial penalty for early withdrawal. APYs current as of 12/9/2011. $1,000,000 maximum deposit. Rates are subject to change. Fees could reduce earnings. BBVA Compass is a leading U.S. banking franchise with operations throughout the Sunbelt Region and ranks among the top 20 largest U.S. commercial banks based...
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Wonder Where Your Neighbors Went for Thanksgiving?
Mike Stanz
Nov 26
Thanksgiving is one of the biggest travel times of the year. People go amazing distances to be with their friends and family to celebrate and break turkey. The folks at The New York Times put together a pretty interesting graphic presentation to...
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What if You Threw a Press Conference and No One Came?
Mike Stanz
Nov 26
Blaine Gabbert is the current starting quarterback for the San Francisco 49'ers. And he's been doing okay since replacing the struggling Colin Kaepernick. He showed up to a press conference yesterday. And he was the only one to show...
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Thanksgiving is Saved
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Nov 26
Thanksgiving is a time for family gatherings. And when family gathers, sometimes things can get a little heated. Well, now that can be fixed. If the conversation around the carved turkey takes a turn for the worse, just plug in a little Adele...
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More Patriots Controversy
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Nov 25
It seems like the New England Patriots are magnets for controversy. The whole Deflategate thing is finally winding down, but now the 10 & 0 Pats have another tempest brewing. At least this one isn't about them. It happened to...
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"Never Talk About Sex, Politics or Religion"
Mike Stanz
Nov 25
This may be the most awkward exchange ever between two people who make their living with comedy. Stephen Colbert had Bill Maher on his show the other night, and the discussion turned to religion. Stephen's a practicing Catholic - "doesn't...
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"A New Classic for a New Generation"
Mike Stanz
Nov 25
There's been a lot of buzz surrounding Creed, aka Rocky VII. In this one, the son of Apollo Creed turns to Rocky Balboa to manage him as a boxer. Sort of putting Rocky in the Mickey spot. And putting Sylvester Stallone back in the spotlight...
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Hello, Miss Piggy
Mike Stanz
Nov 25
Adele has taken over the entertainment world as the year closes out. She was on Saturday Night Live this weekend, she pulled that prank with Adele impersonators on the BBC, and her song "Hello" is doing phenomenally well. So well, it's...
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Burying the Star Wars Hatchet
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Nov 25
Jimmy Kimmel Live has a long-standing running gag suggesting that Harrison Ford is feuding with Chewbacca from the Star Wars franchise. Something to do with a woman - "a long time ago... in a galaxy far, far away," says Jimmy. Last night, it looks...
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Take Off the Football Helmet, Put on the Dunce Cap
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Nov 25
Johnny Manziel - the NFL quarterback who'd prefer to be known as Johnny Football - was named the starting QB for the Cleveland Browns for the remainder of the season. That was last week. Yesterday, he lost the starting position. He also lost...
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Single Celebration
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A Devilishly Delightful Halloween Costume Ball
It doesn't take a rocket scientist to figure out that horror and sexiness make an alluring combo. This weekend, the folks at Le Cirque Rouge Cabaret & Burlesque will be titillating and terrifying onstage with an evening featuring a variety of new, Halloween-inspired performances. Switchblade Side Show will up the stakes and the drama with carnival-style performances including straitjacket escapes, razor-blade swallowing, whip acts, and magic. The always naughty Ballet of the Dolls will also take the stage, and music will be provided by Fates Palette and Courtney McLean and the Dirty Curls. There will be tarot-card readers on hand as well, should you want to take a glimpse into the future (or reflect on the past). Be sure to come in costume, as a contest is planned for the witching hour. 21+. (Pictured: Le Cirque Rouge Cabaret & Burlesque)
Sat., Oct. 27, 8:30 p.m., 2012
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I have never actually really done exercises to help my balance on a horse so I would like some ideas. Because the last three years I have either been riding pregnant or shortly after having a baby and my core muscles are far from what they should be. Sense this is my last baby I want to do some things to help regain my balance and help my core a lot more.
Does anybody have any good exercises that help? They need to be exercises I can do on my own without having someone lunge me or lead me on my horse because that would not go well at all. I do ride often without stirrups because I am more comfortable without them. Also, I don't ride with weight in my stirrups. I don't know if that will have any affect on the exercises or not.,


text:
No; a regard for truth compels us to state, that on this particular occasion, poopy acted the part of a hypocrite.
"poopy's gone," gasped Corrie, after a few seconds had elapsed.
When, therefore, poopy received the slap referred to, she immediately dried her eyes and looked humble.
"Niggers ob dis here settlement is good mans, ebery von," said poopy, promptly.
Meanwhile Alice untied his neckcloth, and poopy tore open his Guernsey frock and exposed his broad, brown chest.
At this, poopy manufactured an expression on her sable countenance, which was meant to be intensely knowing and suggestive.
poopy, whose wits were sharpened by love, at once took advantage of her opportunity.
We say extraordinary, because poopy, being ingenious, hit upon many devices of an unheard of nature to accomplish her object.
At this, poopy manufactured an expression on her sable countenance which was meant to be intensely knowing and suggestive.
poopy, although sluggish by nature, was rather abrupt and violent in her impulses at times.
Depressed; also, ineffectual: She felt poopy when they left her out (1957+)
Excrement •Mainly a children's word: poopy in the diaper


text:
'You like some other chap. You like some chap, and don't want me interfering in your life. That's why you wants me to go back and live with my wife. You don't think of what I've gone through with her already.'
'You've not been through half of what I have. I'll be bound that you never wanted a dinner. I have.'
'Esther, think of the child.'
'You're a nice one to tell me to think of the child, I who worked and slaved for him all these years.'
'Then I'm to take no for an answer?'
'I don't want to have nothing to do with you.'
'And you won't let me see the child?'
A moment later Esther answered, 'You can see the child, if you like.'
'Where is he?'
'You can come with me to see him next Sunday, if you like. Now let me go in.'
'What time shall I come for you?'
'About three--a little after.'
WILLIAM Was waiting for her by the area railings; and while pinning on her hat she thought of what she should say, and how she should act. But she didn't know her mind, and it was not till the long black pin that held her hat to her hair went through the straw with a little sharp sound, that she decided that when the time came she would know what to say.
As he stepped aside to let her go up the area steps, she noticed how beautiful were his grey trousers, and that he wore a bunch of carnations in his spick-and-span morning coat. 'Quite a toff,' she said to herself, and they walked some half-dozen yards up the street in silence.


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Posts Tagged 'art'
If you're lucky enough to be in New Orleans through the end of the month you can catch a glimpse of this beautiful new Mark Ryden painting, on display at Red Truck Gallery as part of their current Small Indignities group show also featuring work by Marion Peck, and Camille Rose Garcia, among others. Read More
Visionary LA artist Doug Aitken has returned to Shaun Regen's venerable Regen Projects gallery with his latest dazzler of a show, Still Life, that is one of the city's few must-see exhibitions of the season. Spanning a variety of media encompassing photography, sculpture, publications, sound, and Read More
We can't get enough of San Francisco-based painter Casey Gray's work here at Supertouch, and his current show Of Land & Sea at Dallas' Circuit 12 gallery does nothing to lessen our enthusiasm. Working exclusively with acrylic spray paint, Gray has developed a distinct approach to contemporary painting that is uniquely Read More
Long time Supertouch buddy KAWS has become a true force of nature in the art world in recent years. Emerging from his early roots in animation and graffiti in the 90s to reign over streetwear and the vinyl toy industry in the 2000s, the artist known to his parents as Brian Donnelley is now a major player in the art world. This meteoric ascendency is due in large part to his prodigious and unrelentingly stunning Read More
In Medias Res, (Latin: "in the midst of things") in narrative technique, the recommended practice of beginning an epic or other fictional form by plunging into a crucial situation that is part of a related chain of events; the situation is an extension of previous events and will be developed in later action. The narrative then goes directly forward, and exposition of Read More
LA-based artist Sam Falls has long pursued a particular interest in the influence of natural phenomenon such as light, rain or time and wind may have on his abstract paintings and sculptures. The idea of a sublime deterioration, a controlled and expected change on materials ranging from Read More
Straight-up summer Simpsons fun in the streets of NYC at 231 Eldridge St, LES, by Jerkface & the accompanying fine art piece to match... Read More
Opening last week to a packed house was Sweetheart, the newest body of work by Japanese street art pioneer Lady Aiko at Steve Lazarides' The Outsiders Gallery, in Newcastle, England. Best known as a founding member of street art collective Faile, Aiko (aka: Aiko Nakagawa) began her career in film, directing the seminal Read More
Wrapping up on September 13 at Gagosian's W 21st St NYC gallery is the awe-inspiring show of new "junk" sculptures by LA-based (but Texas born) artist Nancy Rubins, Our Friend Fluid Metal. The title of the exhibition and its sculptures invokes the Read More
Living Pop Art legend and all-around eternal sun god, Kenny Scharf has returned to his street art roots with a vengeance in recent years, firmly reasserting his rightful place at the top of the pantheon of the pioneers of NYC aerosol art. He's been on a tear with the Montana cans this summer, and perhaps no project was more immediately gratifying than his new mural for freewheeling hipster beach retreat, the Playland Motel in Read More


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A post in another thread suggests that Landis is the 4th most accomplished American bicycle racer. Obviously the complete book on Floyd is yet to be written, but I thought that was an interesting observation. Personally, I would put him 7th based upon performance to date. The 6 ahead:
1) Armstrong.
2) Major Taylor (dominated European competition overcoming tremendous obstacles)
3) Greg Lemond.
4) Andy Hampsten .(2 tours of Switzerland , 1 Giro, epic Giro stage win, 4th TDF, Alpe de Huez stage win in TDF, Tour of Romandy.)
5) Tyler Hamilton (dauphine libere, LBL, Tour of Romandy, Stage wins Giro and TDF)
6) Davis, the Cash register, Phinney ( most wins of any US rider with 300 wins, 2 TDF stages , first american road stage win in TDF, Coors Classic, 2nd in points competition TDF).
Am I leaving anyone out?


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Follow us:
All Content for Animal rescue
On Sunday 13 January, the International Fund for Animal Welfare (IFAW) team drove into the footprint of the Dunalley, Read more »
In every family there comes a time when the children have grown up and are ready to live on their own. Children look Read more »
Devastating bushfires are burning across large parts of South-Eastern Australia, with homes destroyed in Tasmania, Victoria Read more »
A huge thank you to everyone who donated to help save Asian elephants. The funds raised will make a massive difference to Read more »
This post was originally filed by Mila Danilova in our Russian office. -- EZ Two wintering bear cubs named Zahar (male) and Read more »
The Wild Animal Orphanage (WAO) in Northwest San Antonio Texas was forced to close due to a financial crisis. The Read more »


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Hello to you , I am a fun , loving , honest lady . I love auctions and estate sales . I love singing , going out dancing every now and then . Good dinners , I love Jesus and would love to meet a good Christian guy .
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58 • Lafayette, AL • Woman
I'm looking for
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- 5' 5" (1.65m)
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- Christianity and it's important
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I am busy , busy and its time for a wonderful man to come into my life !! Are you out there ?? I just want to be the best person I can be , live in peace and harmony and love and enjoy life everyday with someone who is special to me and vice versa .
I'm really good at
Go on, brag a little (or a lot). We won't judge.
I am Dog breeder and I have the most beautiful puppies here in Alabama . I'm good at singing !
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I love to read any book that has words , I love a good comedy , a love story & drama movies . I love 60s , 70s and current songs in country , rock .
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Think outside the box. Sometimes the little things can say a lot.
The six things I could never do without is God , my kids , music , good food , good times , and right now my electric blanket !
I spend a lot of time thinking about
Global warming, lunch, or your next vacation… it's all fair game.
How to run my business better . my children , my puppies ,and how my next relationship will be so much better .
On a typical Friday night I am
Netflix and takeout, or getting your party on — how do you let loose?
I usually head out for a couple hours to sing karaoke !
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You should message me if want the best friend of your life !!!
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Additional file 2.
Embayment characteristics, 2001 – 2003. Ranges (minimum and maximum) of values for mean station depth, percent vegetation, and secchi depth for each year. Species diversity (Simpson's diversity index) was calculated based on all individuals captured during July 2001–2003. Annual piscivore biomass (BPUE) was calculated for all piscivorous species. Quadratic equation r2 values for maximum biomass weight class (h) estimates are shown in parentheses.
Format: PDF Size: 105KB Download file
This file can be viewed with: Adobe Acrobat Reader
Arend and Bain BMC Ecology 2008 8:23 doi:10.1186/1472-6785-8-23


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With 1.7 million freelancers, we'll match you with the perfect talent.
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Need a custom mobile app.
I need someone who is very experienced in coding for iOS to create a feature rich, nice looking, mobile app.
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This needs to be completed quickly and rich in detail.
- Someone who cannot only program but can also do the UI design and photo/special effects,
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- Please reply with examples of your previous work including any user interface and design examples you have done before. If I like your previous work, I will reply and give you more details.
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It is important to understand different units of weight and measure precisely when taking care of animals.
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Indicator species are used as an early warning of pollution or degradation in an ecosystem.
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Gliding on a wave of electromagnetic force, a maglev train could travel at 300 miles per hour or faster. Designer-engineers describe the mechanics and future benefits of such superconductor...
Take your students inside Easton Sports? research & development lab to meet engineers and technicians who are using math, science and technology to design and test high-performance baseball and s...
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Spotlight Article:
Small Commercial Equals Big Opportunity
Bringing Your Residential Home Performance Experience to the World of Commercial Performance
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text: 13 of us aged from 4 to 64, stayed here for 8 nights. We were delighted for so many reasons. The German lady was extremely welcoming and friendly, we knew a few words of German and used our translate app on our phones. Our apartments were roomy and spotlessly clean.The pool was small but perfect for all the ages. We... More


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April 22, 2010
Shortly after 7am Thursday morning, WWCC grounds maintenance person Ray Warnberg was out removing red tape in preparation for a day of going green at the college. The red tape had sanctioned off two large areas of the WWCC parking lot that had been reserved for carpoolers heading to college on Earth Day.
Stories this photo appears in:
'Green' commute day a time to reflect
Besides spurring thoughts about the environment, a walk to work makes for a serene start.
The morning air on my face was a pleasant alarm clock as I stepped off the front porch for a sneaker-clad commute.Resolved to commemorate Earth Day as the diehards do, I began the 1 1/2-mile journey to work on foot rather than behind the wheel, determined
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Role-Playing (RPG)
DescriptionRole-playing video games are descendants of pen-and-paper RPGs. In those games character development is the main driving gameplay mechanic. Typically one or more characters are created and shaped by the player, then embark on a series of encounters that increase the inventory, wealth, or combat statistics of said character(s).
A role-playing game is not just any game in which the player "plays a role", i.e. controls a character and participates in exploration and narrative. Rather, the defining characteristic of role-playing games is player-dependent character growth. A role-playing game can be seen as such when player-controlled characters become stronger ("levels up") because of the player's actions (usually depending on experience points received for vanquishing enemies), rather than being upgraded automatically as dictated by the storyline. The degree of the player's involvement in shaping the characters may vary considerably: some RPGs offer vast customization possibilities, while others tend to simplify and even nearly automatize the process.
Traditional RPGs have turn-based combat and a fantasy setting (Wizardry series, Ultima series, Roguelikes, etc.). Later, other settings were introduced, and many RPGs - such as Diablo - began favoring action-based combat. In these games, Action is used as a modifier to the RPG genre.
By the late 1980's, the genre has been distinctly split into two main sub-genres: Western and Japanese (sometimes called console-style) RPG. Western RPGs typically favored free exploration and player-made decisions, while Japanese RPGs focused on following a linear story line. Japanese RPGs also tended to retain simple turn-based combat mechanics, and in many cases also random enemy encounters.
In many early Western RPGs the player was given the option to create an entire party of characters (usually up to six). Ultima games introduced the possibility of recruiting initially non-playable characters (NPCs) with their own personalities from the game world into the party. Beginning with Phantasy Star, Japanese RPGs followed this template and even elevated it to their cornerstone mechanic.
Late 1990's saw a "RPG revival" in the West. Fallout greatly expanded the usage of non-combat statistics and moral decisions during gameplay, while Baldur's Gate popularized real-time party-based combat.
|Game Title
Nintendo DS (2006)
Magical Starsign is Role Playing Game about a group of students at the Will O' Wisp magical academy. When their...
Game Boy Advance (2001) and Wii U (2015)
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Part of the Magic Candle series, this is much like the first game in the series, only with an enhanced...
DOS (1989), NES (1992), Commodore 64 (1989), Apple II (1989) and PC-98 (1991)
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Merlwood was once a land of peace and prosperity. The people lived in harmony with one another and with their...
Amiga (1995) and Amiga CD32 (1995)
Classical dungeon RPG with step-by-step movement from Czech Arda Team. You are playing the son of an old warrior, who...
PC-98 (1992) and Sharp X68000 (1993)
The heroine of Magic Knight is called Diamond Annabel Blackdiamond (sic). She is a very... erm... well-endowed young woman who...
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In Magi-Nation, the player takes control of a boy named Tony Jones who is dared by his friends to enter...
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Magiya krovi: Mnogopol'zovatel'skoe dopolnenie is a multiplayer add-on for Dawn of Magic, which is required for installation. It adds five...
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Magiya krovi. Zolotoe izdanie is a gold edition of Dawn of Magic, with multiplayer add-on Magiya krovi: Mnogopol'zovatel'skoe dopolnenie and...
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Xbox 360 (2009)
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The land of Efferia is a huge continent, where five different races co-exist - alas, not always peacefully. At present,...
Windows (2001)
Calintz is the adopted son of King Helios and a famous hero known as "The Phantom of Avalanche" due to...
Magus is a Korean-made hybrid of a role-playing and a real-time strategy game. The game is set in the medieval...
As gods created the Earth, a divine woman, blessed with three powers, descended upon it. These three powers were: the...
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Tag: filtering
Reporters Without Borders yesterday released its 2010 World Press Freedom Index. Thirteen of the EU's 27 members are in the top 20 in terms of press freedoms, but some of the other EU nations are very low. The European Union has had a reputation for valuing and respecting human rights, and new data suggests that […] more »
This episode of 4MR is brought to you by GoDaddy, helping you set up your own website in a snap with domain name registration, web hosting and 24/7 support. Visit GoDaddy to learn more. Here's the latest 4MR audio report from MediaShift. In this week's edition, I look at Google's recent move to stop censoring […] more »
Last summer, the British cell phone carrier Vodafone announced it would be offering a new filtering service for its Czech customers. "Child pornography and promotion of racism [are] such socially dangerous content that we have access to it automatically blocked for all of our customers," said Philip Premysl, senior manager of corporate social responsibility of […] more »
There was a time not too long ago when you could spot spam comments on a blog from a mile away. There were too many links, the comment was off-topic, and they were trying to promote a pyramid scheme website. But as human and automated filters started catching problematic posters, their techniques became more sneaky. […] more »
After the Washington Post's website decided to shut down comments on its Post.Blog, I asked our own budding MediaShift community how you thought blog comments should be moderated here and elsewhere. Should online forums and blogs put up technological roadblocks to spammers and people spewing vitriol? Should they employ humans to check every comment before […] more »


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Dominate the 18th century on land and sea. Command the seas, control the land, forge a new nation, and conquer the globe. Empire: Total War takes the Total War franchise to the eighteenth century Age of Enlightenment — a time of political upheaval, military advancements, and radical thought.
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To Order by Phone : 1-888-614-WINE
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Intense aromas of grapefruit, kiwi and freshly cut grass mix with concentrated tropical aromas and a bright minerality. A blend of fruit raised in the prime growing regions of Mendocino and Lake counties, this wine is the product of local organic viticulture in full flower.
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Akaneiro Ni Somaru Saka
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CRY....CRY....CRY when is the last time YOU cried.....
Thank you so much!
Quoting Bethsunshine:
Quoting livnbyfaith:
A couple of weeks ago when the Dr. told me I had Thyroid Cancer~
I'm sorry to hear that!! Best wishes and prayers to you!!
Quoting KarriePlus1:
Last night, when the doctor told me I had to stay in the hospital so they could keep tabs on the baby.
Quoting jb0520:
On may 28th, the anniversary of my daughter passing away!
Sunday evening. My son said some shitty things to me that he didn't even mean or know what he was talking about but I have been hormonal lately.
I took 100-150mg 1-2 hrs before bed every night cause it also helps with insomnia.
Quoting Anonymous:
I have been crying every single day because I am depressed and can't get help because we can't afford medical insurance for me and the free clinics never call me back when I call begging for help.
Quoting kidlover2:
2 days ago... I was watching a movie that reminded me of my utter aloneness and how much I miss being married


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The parlor floor of this Fort Greene brownstone is about as grand as they come. But there's a catch: The house is currently divided up into five units, including an owner's duplex with only one bedroom. The listing says, "the parlor and garden floors are ready to be renovated to meet your personal needs and design." Does that mean the top three tenants are staying? What do you make of it for $3,999,000?
8 South Portland Avenue [Corcoran] GMAP P*Shark
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Pretty sure that there are some rent stabilized or rent controlled tenants and that's what they are worried about.
the ad copy says "The top three floors comprise three 2 and 3 bedroom income producing rental apartments with market rate rents of over $7300 a month." So presumably the tenants aren't RC/RS, unless the realtor is being really duplicitous. I'd think vacant/renovated/reconfigured this place would be over $5M.
The listing doesn't comment on the lower floor studio; instead they pitch the house as an estate sale and that "The parlour and garden floors are ready to be renovated to meet your personal
needs and design." Presumably the studio is vacant but it is less than clear — stranger things have happened.
Cant you morons ever read the listing before you opine??????
if you are buying a small apartment building the price is dependent on the rent roll. If there are rent-regulated tenants, the rent roll is iffy as those tenants have lifetime tenure and can skip paying rent for years on end with no consequences. If you are buying the property to live in, then it becomes more a question of being comfortable. Rent regulated tenants can make it rather uncomfortable for the nominal owner as they consider themselves in many cases to be the true owner and astonishingly, the law of the land is on their side. Perhaps they can be bought out, perhaps not, it is up to them.
"I'd think vacant/renovated/reconfigured this place would be over $5M."
Are you aware the record for the neighborhood is $3.28M (the park facing 5-story @ 181 Washington)? WTF do you get $5M? Gibberish.
Here is the listing from last summer/fall:
LOL…things have changed a lot since last Summer. Try and keep up.
scarcely gibberish. This block is every bit as desirable as a park-facing block, this house is larger, the market is tighter and rates are lower than a year ago. With a high-end reno this place could approach $1000psf.
Actually 181 WP is no longer the record. A house sold on So. Portland recently for north of $3.8 (?) if I recall the number correctly. Regardless, it is the new record breaker.
Hey boerum, it's not gibberish! No 32 on the same block sold for $3.75m just about a month ago and it is only 4 stories tall.
Disclaimer we own on the block so little biased
BTW for the record there are no RS/ RC tenants there !
True, the new record was set in March. The Q remains: have we appreciated 33% since in the 60 days since then?
Third floor is a layout only PacMan could love.
LOL but what about the 5th floor…even more bizarre
you're bizarre!
Agree DIBS while this is a nice house the configuration is far from desirable on all floors. Will require a ton of work to reconfigure which should lower the asking but who knows with all the recent frenzy….do you think we have a bubble?
Kinda feels like one.
Doesn't show as rent stabilized in the records. Easily a $3m renovation to do it right.
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jGuru Forums
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I am trying to execute a buildfile from within another buildfile using the task. The two buildfiles are located in different directories and both have their base directories set to "." The problem is that the top-level buildfile's base directory remains in effect when the other buildfile is executed and thus, the path's defined in the 2nd buildfile are now invalid. I've tried setting the "dir" element of the task to the proper directory, but this isn't working. I've also tried setting "inheritAll" to false thinking that might be the problem, but no luck. Any ideas what I'm doing wrong? Thanks.
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For maximum mix madness!
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iHerb Customer Reviews
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Great, neutral taste
Posted by Reviewer2124393 on Aug 11, 2009
It took me some time adapting to this flavour, but now I very much prefer it over the 'vanilla/licorice' flavour of some of the competition.
Like this alot!
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I started taking this for some weird abdominal pain that my docs could not figure out. It really helps a lot and i will continue to take it. If you like licorice it's great!
these seem to help
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I was having problems with burning in my stomach. In my research for causes and solutions I learned DGL is highly recommended. I am happy with the results from this product. Personally I think they taste fine, as well.
4 stars
Posted by Reviewer1927028 on Jul 08, 2011
product works well!
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Hot cheerleaders, cool music
Cold, Hard Football Facts for May 04, 2007
An Arizona fan known as "CardLogic" in the Cold, Hard Football Facts message board apparently has a little too much time on his hands as we enter the nadir of the football calendar, the dreaded gridiron doldrums.
His shut-in existence is our gain: he's turned the CHFF World Famous Cheerleader Thread into a movie montage set to the sounds of David Byrne's "Like Humans Do."
The WFCT is an epic piece of work compiled by our most loyal and most seedy readers. But with football ever present in the simple minds of our readers, the thread has also given us two new statistics:
- Breastability Index
- Asser Rating (see the formula above and in the WFCT, from Dutch CHFF reader "Pigskin Science" ... those clever little Dutch, always thinking, aren't they? Of course, we can't even find Dutchland on a map.)
Resident CHFF film critic Bonzo the Idiot Monkey gives Cardlogic's new film one opposable "thumbs up." And it's rated a five-banana film, which means you might want to watch it when wifey ain't around.
Read more: Cold Hard Football Facts, NFL
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Key things you need to know aboutDr. Fayssoux:
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Patients' risk of dying during a hospital stay for heart bypass surgery could be 87.4% lower, on average, at a hospital rated 5 stars compared to a hospital rated 1 star for that procedure. Choosing the right hospital is critical to your health. View Slideshow
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Likelihood of recommending Dr. Fayssoux to family and friends is 4.2 out of 5 5 1 5
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