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HPRC Blog
Welcome to the HPRC Blog. We've got lots of information here, from quick tips to in-depth posts about detailed human performance optimization topics.
The Food and Drug Administration (FDA) and the Federal Trade Commission (FTC) issued warning letters to several companies selling unproven products claiming to treat, cure, and prevent sexually transmitted diseases (STDs). These products—such as Medavir, Herpaflor, Viruxo, C-Cure, and Never an Outbreak—violate federal law because the FDA has not evaluated them for safety and effectiveness. Some are marketed as dietary supplements, but the FDA considers them drugs since they are offered for the treatment of disease. More information is provided in the FDA Press Release.
Vitamin B12 is one of the eight B vitamins and is water-soluble. Our bodies do not store vitamin B12 so we must consume it daily. It is an important nutrient that helps make DNA, the genetic material in cells, and is essential for normal functioning of the brain and nervous system. Good food choices for vitamin B12 are beef liver, clams, fish, meat, poultry, eggs, and other dairy products. Read the Office of Dietary Supplement's Vitamin B12 Fact Sheet for additional information.
The military celebrates the Friday before Mother's Day every year as Military Spouse Appreciation Day. In 1984, former president Ronald Reagan initiated this event to acknowledge and honor the commitment, courage, and sacrifice of the wives and husbands of our nation's service members. Military spouses are the backbone of their families and are key to the success of the Warfighter's military performance. President Barack Obama reflected in his 2010 Military Spouse Appreciation Day speech, "At the heart of our Armed Forces, service members' spouses keep our military families on track."
The Military Family Resource Center reports these statistics about military spouses and/or families:
- Almost 60% the active-duty force has family responsibilities of a spouse and/or children.
- 93% of the spouses of active-duty members are female.
- 54% of the spouses are 30 years of age or younger; 72% are under age 36.
- 56% of active-duty spouses are employed. 14% of active-duty spouses are Armed Forces members themselves.
- 43% of active-duty members have children; the average number of children for active-duty members who have children is two.
- Among active-duty members who have dependents, the average number of dependents is almost 2.5.
- More than 50% of the children of active-duty members are seven years of age or younger.
(Source: 2008 Demographics: Profile of the Military Community, published by the Military Family Resource Center.)
For more information about President Obama's speech, see:
Maintaining a physically fit body requires consistent training and motivation. It's common for individuals to get stale or fall into a training rut. Consider cross-training, adding new activities and exercises, or just doing something physical for fun!
The Department of Defense (DoD) and American College of Sports Medicine (ACSM) convened a workshop at the Uniformed Services University in Bethesda, MD, that examined various aspects and issues of high-intensity training (HIT) programs—now referred to as Extreme Conditioning Programs (ECPs).
The executive summary of the workshop and can be read here.
Last week, we started a four-week schedule of discussing strategies for processing emotions. Each week we highlight one positive strategy (called "savoring") and one negative strategy (called "dampening"). Although research has focused on the impact of these strategies on individual outcomes such as positive emotions and happiness, they seem to be strategies that could also be used with families, friends, and unit relationships to promote positive and happy individuals and interactions.
Savoring (Positive) Strategy #3: "Be Present"
"Being present" is a strategy whereby individuals deliberately direct their attention to focus on pleasant experiences happening in the present. For example, when something positive happens, rather than immediately thinking about the next event or what went wrong, take some time to stay in the moment and experience the happy feelings. In relationships, taking some time to focus on happy events can foster positive emotions in the entire family or unit.
Dampening (Negative) Strategy #4: "Distraction"
When individuals engage in positive events but let other thoughts intrude (like worries), then they experience "distraction." Being distracted decreases the positive impact of the happy event. Distraction is associated with poorer well-being over time. Individuals who are less distracted tend to be happier in their relationships, as well.
Taken together, next time something positive happens, stay present, don't let yourself be distracted, and see if the positive feelings linger longer than usual. Try this within your family, couple, or unit.
Come back next week for strategies five and six.
We know about colas, coffee, tea, and chocolate, but caffeine can also be found in some over-the-counter drugs and herbal dietary supplement products. Energy drinks contain caffeine, and some also contain guarana, a plant with high amounts of caffeine. Yerba mate, green tea extract, and kola nuts are also sources of caffeine, and can be found in weight-loss and performance-enhancing dietary supplements. Be sure to read labels for hidden sources of caffeine.
The American College of Sports Medicine and the American Heart Association recommend doing moderate-intensity cardiovascular exercise for 30 minutes a day, five days a week (for details of these guidelines, click here). However, elite athletes and tactical Warfighters need to train more to achieve higher levels of fitness—see the Navy Seal Fitness Guide and the Building the Soldier Athlete Manual for more information.
A recent study examined eight different strategies for processing emotions and how they are linked to positive emotions and life satisfaction. The HPRC will describe two of these a week for the next four weeks. Although research has focused on the impact of these strategies on individual outcomes such as positive emotions and happiness, they also seem to be strategies that could be used with family relationships, friends, and comrades to promote positive and happy individuals and interactions. Additionally, parents as well as leaders could help foster positive strategies (called "savoring") to help their children or their units decrease their use of negative (or "dampening") strategies.
Savoring (Positive) Strategy #1: "Behavioral Display"
A "behavioral display" is a savoring strategy when an individual expresses positive emotions through non-verbal behavior. For example, when a child gets an "A" on a test, he or she has a huge smile, exhibits overall happy body language, and in essence seems to exude happiness. This expression of positive emotion appears to be contagious (in a good way) in relationships.
Dampening (Negative) Strategy # 2: "Suppression"
"Suppression" is a strategy whereby individuals hide their positive emotions for a variety of reasons (possibly shyness, modesty, or fear). Individuals who push down their positive emotions tend to report less life satisfaction and lower psychological well-being.
So the next time something positive happens to you, allow yourself a behavioral display of emotion and see if it makes others around you happier too. Likewise, next time something positive happens and you don't show a positive reaction, compare and see how it impacts your emotions, well-being, and overall happiness.
Next week, we'll discuss two more strategies—one positive and one negative—that you can try out.
True total force fitness and overall well-being are crucial to Warfighter readiness and success, and awareness of this is now spreading like wildfire. Admiral Mullen's Total Force Fitness Initiatives center on the importance of mind, body, family, and environment for overall Warfighter resilience.
There are numerous programs within the military designed to support and enhance Warfighter resilience – some unit specific and some branch or joint-service specific. The HPRC is in the process of gathering information on these myriad programs and highlighting those that are clearly evidence-based, that highlight the importance of mind-body integration, and that teach Warfighter-relevant skills and strategies for performance optimization.
Last week we added a section in our Total Force Fitness domain on the Comprehensive Soldier Fitness (CSF) program. We describe the program, give step-by-step information about its components, and highlight where to go for more information and program participation.
To give you a brief overview, CSF is an integrated Total Force Fitness (TFF) resilience-building program developed by the Army in collaboration with researchers in positive psychology and resilience building. CSF is designed to give Warfighters, their families, and their communities the knowledge, skills, and behaviors to "thrive in their lives" and successfully adapt to life's challenges. Consistent with some of the components of Total Force Fitness identified by the DoD, CSF has five basic sectors: physical, social, emotional, spiritual, and family.
CSF was initially developed for the Army community, but it has now been adapted for use by the Air Force, Navy, and Marines. In addition, CSF provides training tools specifically designed for family members. Most of the training materials require AKO/DKO access, but the main exception is the family member materials, which are available for immediate download (with registration).
We hope that this new area of our website will be useful, help foster resilience in all, and provide a one-stop shop for previewing some resilience programs ongoing within the military.


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Kajika 8 released in mangahere fastest, recommend your friends to read Kajika 8 now!
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Samos is a Greek island in the eastern Aegean Sea, and off the coast of Asia Minor, from which it is separated by the 1.6 kilometre Mycale Strait.
It is home to Pythagoreion and the Heraion of Samos, a UNESCO World Heritage Site that includes the Eupalinian aqueduct, a marvel of ancient engineering. Samos is the birthplace of the Greek philosopher and mathematician Pythagoras, after whom the Pythagorean theorem is named, the philosopher Epicurus, and the astronomer Aristarchus of Samos, the first known individual to propose that the Earth revolves around the sun. Samian wine was well known in antiquity, and is still produced on the island.
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Were not alcoholics, were just impatient for fridays
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Alcoholics go to meetings. We're drunks.
Well there's only one a week. Geeze.
This might be the best motto ever.
Were impatient for weekends!
Unlike alcoholics you don't quit your craft
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Pull all bids and dont buy, let them sell among each other and let them bring it down to a penny. You fakks keep buying into there games.
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Best of the Decade: From Brad, Jennifer, and Angelina to Britney to Celebrity Babies, Check Out 10 Years in Pop Culture!
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It's been an incredible decade in the celebrity and pop culture worlds — it was so hard to narrow it down to the 10 biggest stories! We've got franchises we love, from Harry Potter to Twilight, plus the never-ending rumors surrounding Brad Pitt, Jennifer Aniston, and Angelina Jolie. We couldn't keep our eyes off Britney Spears, from her dramatic head-shaving to her remarkable comeback. Those are just a few of the stories from our PopSugar Rush Best of the Decade special — watch it now!
Read More Best Of The DecadeBest Of 2009POPSUGAR NewsJennifer AnistonBrad PittAngelina JolieBritney Spears
Jennifer Aniston
Angelina Jolie
Britney Spears
POPSUGAR, the #1 independent media and technology company for women. Where more than 75 million women go for original, inspirational content that feeds their passions and interests.
jenis1 5 years
shut up wuss
jenis1 5 years
shut up wuss
jenis1 5 years
loons NEED to move on and stop bringing up Jen in the stupid couple threads.
los-angeles-1 5 years
well said anonymous#9
los-angeles-1 5 years
well said anonymous#9
OoOThisIsMeOoO 5 years
great list! i think that maybe the only thing that was forgotten was how much more crazy the paparazzi have gotten the past 10 yrs. They bearly any privacy for celebrities and their children. Also, Lady Gaga. I can see her being around for a long time from now because she's so talented and shocking that she keeps people interested.


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90210 generations past and present converged at the 2008 Gemini Awards at Intercontinental Hotel's Metro Toronto Convention Centre last week.
Jason Priestley and Shenae Grimes met up on the red carpet at the event.
Priestley will direct an episode of 90210, which will air this spring. It's rumored to be the first new show upon 90210's return in January.


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Base Stage 2 is fine where it is (6 Votes)
Add more to stage 2 (9 Votes)
Silver with 3k (11 Votes)
Blue with 19k (3 Votes)
If you own a new WRX like I do, you may be wondering what and when you need "things" changed, oil changes, air filters, tire rotations, sparkLast Post By: WRX-Joe Today, 11:10 AM
When my title gets back from my current car, I plan on doing a trade in for a used 2009 WRX. I just have a few questions.
1) I know, as
Does anyone know if there is a Cobb map for the mishimoto intake along with the mishimoto catback exhaust? I just bought them and want to make sure everythingLast Post By: XJman Yesterday, 11:50 AM
Hello everyone, Just bought a 2016 WRX last night.Last Post By: WRX-Joe Today, 10:32 AM
Greetings All,
After an impulse, created by my friend, I bought a 2015 WRX Base. So far the car has been awesome. It's been somewhat off
2015 WRX.. About 130 miles ... Owners manual states not to go over 4000 rpm for first 1000 miles.. Geez.. I've done that a few times already, I'veLast Post By: XJman 11-28-2015, 07:10 PM
Hey guys, I got a 2016 sti and I am looking into getting a dashcam.
I've been looking at the kdlinks x1 and the support is very responsive. They've
Hey guys, so I believe my clutch went out a few days ago, the previous owner had the transmission rebuilt along with a stage 2 clutch installed a littleLast Post By: XJman Today, 02:15 PM
I have a 07 xrx. It is the hybrid swap, sti block with wrx heads.
It is already tuned in 16 psi I just want to make some adjustments to the existing
Would anyone be able to walk me through what could be wrong?
Installed a boomba short throw on my 15 WRX and now cant get into 5th or 6th.
So I just purchased a 2015 Wrx with 3100 miles about 1 Week ago, and this morning I got in my car and let it warm up for about 10 minutes as I usuallyLast Post By: Eocene Today, 09:44 AM
I replaced pads and rotors 2 months ago on my 2008 WRX. When changing the pads and rotors I noticed that the passenger rear pad and rotor were essentiallyLast Post By: SD_GR Today, 07:40 AM
Need to sell the car and I'm selling all the bits I installed before it goes. Complete COBB Stage 2+ Package off a 2014 STI Hatch. Its all here, nothingLast Post By: Design Ent Today, 05:55 AM
I have a Cobb Accessport that I bought for my 2015 WRX MT. I had an personal accident and shattered my left leg rending my ability to drive a manualLast Post By: irickchad Yesterday, 04:31 PM
300 picked up, 330 shipped
No trades
Comes with Y pipe.
360 609 2841
Vancouver, WA Portland OR
For sale is my 02 wrx hybrid swap with a fresh paint job.
Reason for sale? Stationed overseas, car is taking up space and don't have time for


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20 Relationship Lessons Everyone Should Know
20 Relationship Lessons Everyone Should Know
Relationships, while they are beautiful and rewarding, are a lot of work. A good relationship must be balanced. Each partner must be willing to give and take in all areas and aspects of the relationship. Every relationship is different and there is no manual or how-to-guide to make things work out. Each relationship will have ups and downs and each couple will learn valuable lessons along the way.
Here are 20 lessons I've learned along the way that may help your relationship overcome bumps in the road throughout your journey together.
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What Watch Night Really Means for People of FaithWhile the Watch Night service has its roots in the Methodist church, these services...
Did You Know These Celebrities Were Devout Christians?...Over the years, Hollywood has had a strong reputation for being a spiritual...
How to Keep Christ in ChristmasAs Christians, we know the importance of keeping Christ in Christmas. Unfortunately,...
Going Out of Town: 5 Things Every Homeowner Should...Protect your home, and property before you leave for vacation.
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The Center Of The Universe Is Life - video
John 1:4
In him was life; and the life was the light of men.
Intelligent Design - The Anthropic Hypothesis
Excerpt: In fact, depending on how much relative importance can be found in a single person, the whole universe could truthfully be said to be "centered on" a single person. Thus, much contrary to the mediocrity of earth and of humans, brought about by the heliocentric discoveries of Galileo and Copernicus, this finding of a "4-dimensional space-time" for our universe is in fact very comforting to Theistic postulations in general, and even lends very strong support of plausibility to the main tenet of Christianity which holds Jesus Christ is the only begotten Son of God.
Matthew 28:18
And Jesus came up and spoke to them, saying, "All authority has been given to Me in heaven and upon earth."
As well, I find the fact this seemingly insignificant earth is found to revolve around the much more massive sun to be reflective of our true spiritual condition. In regards to God's "kingdom of light", are we not to keep in mind our lives are to be guided by the much higher purpose which is tied to our future in God's "kingdom of light"? Are we not to avoid placing too much emphasis on what this world has to offer, since it is so much more insignificant than what heaven has to offer?
Louie Giglio - How Great Is Our God - Part 2 - video
Psalm 8: 3-4
When I consider Your heavens, the work of Your fingers, The moon and the stars, which You have
ordained; What is man that You take thought of him, And the son of man that You care for him?


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My uncle who now lives in Australia took this picture over 50years ago. I was born in the country in a house across the road from this house/come shop for the local farming area. He used a "Brownie" camera i do believe. Even in those days he had his own dark room. Developed all his own pictures. I just wanted to share it with you all. Thanks for looking....
|Past days...
|21 Oct 2010 - 10:02 AM
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Technically not perfect but a lovely journey back in time. Thankyou for sharing it with us.
Nominating Constructive Critique
Thankyou David, i did'nt do anything to it. I just thought it should be left alone.Thanks again for your welcome comment..Jim.
Nominating Constructive Critique
Thankyou, David and Moira for your kind comments and votes.I've only started to upload photos this week and all the comments i can get are really welcome. I,m off tonight for the weekend, with my camera ofcourse. Weather forecast here in N.Ireland not looking to promising but we will see, no rain in the pubs,hee,hee....Thanks also to all who gave me votes...Jim.
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Andrew_Hurley at 28 Oct 2010 - 10:39 PM
Quote: no rain in the pubs, hee, hee....Jim.
There is rain in Weatherspoons!
Nominating Constructive Critique
Thanks Adam and Andrew, there was no rain in the pubs i was in, nor indeed was there any weatherspoons either,ha,ha...JIM.
Nominating Constructive Critique
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My name is Ashley. I am currently working and attending school fulltime. I currently work with special education and behavioral third grade. I absolutely love my job. I believe my purpose in life is helping children in rough times. My major is in psychology minor early childhood dev. I am working on becoming a child psychologist specializing in helping children neglected and abused. I am from New Mexico born and raised. I have no kids. In the free time I never really have I like going to movies,bowling,pretty.much anything.... I do not like the club status much but do like to have an occasional drink now and then... I am not really sure what it is I am looking for. I seem to meet all the wrong guys. I will tell you right now I am not a child and do not play games. So if your drama or even think for a second you are gods gift to earth meaning in egocentrism. Please do not even bother writing me or with my time. Also, I mentioned my name for a reason do not call me sexy and hot etc. I find it immature and disrespectful. All in all I may seem serious but when it comes to work, school and my heart....well ofcourse I am. Do you blame me? Other then that I'm a very genuine fun loving person. I, have many blonde moments ..... I love to make people laugh. I am just one to go with the flow. Well if you have any questions please ask =)Baby mamma or ex drama, broke,immature,or selfish.PLEASE don't waste my time! Add on no COPS..egocentric ***holes ;)))...
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24 • Rio Rancho, NM • Woman
I'm looking for
- Men
- Ages 23-30
- Near me
- Who are single
- For new friends, long-term dating, short-term dating
My details
- Last online
- Nov 18
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- 5' 4" (1.63m)
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- Average build
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I love books on psychology.
Criminal minds
Greys anatomy
Blue bloods
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Pearl harbor
Schindlers list
Criminal minds
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Blue bloods
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Pearl harbor
Schindlers list
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Think outside the box. Sometimes the little things can say a lot.
Ice cream
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Netflix and takeout, or getting your party on — how do you let loose?
Home watching movies and relaxing.
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Everything You Never Knew You Wanted to Know About Berlin And Kreuzberg
Now, here´s a brilliant idea presented by an excellent blogger – An English Man in Berlin about BookFlaneur.
Originally posted on An English Man in Berlin:
If you live in Berlin and you like books, you'll be as excited as I am about Book Flaneur – a novel way of introducing Berliners to books!
I spoke to Nadia and Piotr, the people behind this new community project, to find out more.
Tell us how Book Flaneur works.
We love to call Bookflaneur the ultimate matchmaker for blind dates with books in Berlin. The idea is simple:
Step 1: We lovingly wrap a book
Step 2: We label it nicely to hint at the genre, feel or plot
Step 3: We map secret pick-up locations via Twitter and Google Maps
Step 4: We drop it off at a local business, bench in a park, U-Bahn station or anywhere else
Step 5: A book lover picks up their date
How did you come up with the idea?
Both of us have a soft spot for books. Nadia likes…
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Kiezimpressionen "in, zu & am Schloss Charlottenburg"
Berlin projekt 2010
- fine art
What you see everyday but you don't know
a year in the life of death
Dress like a man
Current & Breaking News | National & World Updates
Augmented Reality Handyrallye
rag-picking history
Projektsite LEA/LLCE, Université de Provence
Walking Tours with Old Maps
News about Typekit
Star Wars as an Icelandic saga, and other fun with Old Norse.
Der Blog Uff Berlinerisch!
Familienportrait - 100 Jahre Geschichte einer Berliner Familie & Berlinische Leben und Räume - Autobiografische Texte


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NEWS RELEASE TRANSMITTED BY Marketwired FOR: Manitok Energy Inc. TSX VENTURE SYMBOL: MEI FEBRUARY 4, 2014 Manitok Energy Inc. Announces Grant of Incentive Stock Options CALGARY, ALBERTA--(Marketwired - Feb. 4, 2014) - NOT FOR DISTRIBUTION TO U.S. NEWSWIRE SERVICES OR FOR DISSEMINATION IN THE UNITED STATES OF AMERICA. Manitok Energy Inc. (the "Corporation") (TSX VENTURE:MEI) announces that its board of directors approved the granting of incentive stock options ("Options") under its stock option plan to certain of its directors, officers, employees and consultants to acquire up to an aggregate of 1,134,000 common shares ("Common Shares") of the Corporation. All of such Options are exercisable for a period of five years at a price of $2.40 per Common Share and 33 1/3% of the Options will vest one year after the date of the grant of such Options and the remainder will vest 33 1/3% per year thereafter. Upon the granting of the Options described above, Manitok will have 6,452,773 Options outstanding, which represents about 8.8% of the 73,700,973 Common Shares currently outstanding. Manitok's stock option plan currently limits the issuance of Options to no more than 10% of the outstanding Common Shares. About Manitok Manitok is a public oil and gas exploration and development company focusing on conventional oil and gas reservoirs in the Canadian Foothills and Southeast Alberta. The Corporation will utilize its experience and expertise to develop the untapped conventional oil and liquids-rich natural gas pools in both the Foothills and Southeast Alberta areas of the Western Canadian Sedimentary Basin. Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release. -30- FOR FURTHER INFORMATION PLEASE CONTACT: Manitok Energy Inc. Massimo M. Geremia President and Chief Executive Officer 403-984-1751 email@example.com INDUSTRY: Energy and Utilities - Oil and Gas SUBJECT: STK -0- -0- Feb/05/2014 04:41 GMT
Manitok Energy Inc. Announces Grant of Incentive Stock Options
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By On the occasion of our 20th anniversary
Why Do Mexis Like Wrought-Iron Fences?
By Gustavo Arellano
By R. Scott Moxley
By Alfonso Delgado
Women For: OC are Stitching and Bitching
By Courtney Hamilton
Santa Ana River Ready for Its Renaissance
By Joel Beers
By Peter Maguire
Can Tech Ruin the Kim Pham Murder Trial?
By Charles Lam
UC Irvine professor Rainer Klaus Reinsheid is accused of starting fires at University High School, the home of the high school's assistant principal and the Mason Park Preserve. Officials discovered private emails written by Reinscheid, detailing his thoughts about "getting a dozen machine guns" and going to the Irvine school to "shoot at least 200 students before killing myself." He penned the notes a month after his 14-year-old son hanged himself, reportedly after being tormented and bullied. Mitigating factor: The alleged actions of Reinscheid are scary, but the consequence of untreated mental illness is what's truly terrifying.
Cool: The Costa Mesa-based developer created the LAB and the Camp "anti-malls," funky-hipster meccas that have become the antithesis of OC's ubiquitous beige-stucco shopping centers. And now he's trying to do the same with downtown Anaheim. Not so cool: Shaheen Sadeghi has been accused of stealing ideas from indie business owners and preying on inexperienced entrepreneurs. He's known to lure new companies into his retail centers, but if these "little guys" turn out to be "weak tenants," in his words, he'll push them out, typically by spiking the rent. One former tenant summed it up best: "Shaheen is not out to enhance the community—he's out for Shaheen, period." Mitigating factor: He recycles.
This article appeared in print as "Child Molesters, Serial Killers and Dana Rohrabacher: Our picks for OC's Scariest People 2012!"
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Ithaca College Students Tune into Healing Power of Music & Memory
ITHACA, NY — The Ithaca College Gerontology Institute and Music & Memory — a nonprofit organization that helps improve the quality of life for people with dementia by bringing personalized music into their lives — have teamed up to use the therapeutic power of music to combat memory...
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Earth Defense Force is one of those franchises that seems to fall by the way side every time there's a new release. Earth Defense Force 2017 came out at the infancy of the Xbox 360 and didn't get a good foothold; now its sequel comes out at the onset of the new console generation. Hopefully this won't hurt the games reception this time around because D3 has crafted an amusing, lengthy and campy game.
Earth Defense Force 2025 is very much like the overlooked Dynasty Warriors games, but only to a point. The game drips with Japanese influence and is very deep. EDF alone is 85 missions, and that's before you replay them using different classes. There are four in all, Ranger, Wing Diver, Air Raider and Fencer. The Ranger is the typical foot soldier, can drive vehicles, holds two types of weapons and is easy to control. This is the class that I took through the game. The Wing Diver is an all female squadron of flying soldiers with advanced alien tech strapped to their backs; they zip in and out while blasting bugs, but ammo and the jet pack operate off the same power supply. The Air Raider is basically a promoted Ranger; he can call in air strikes, and specializes in explosives and grenade launchers. Fencers are heavily armored mech wielding soldiers that can carry up to four weapons and use jet bursts to dodge and jump. Though every class can be used in all 85 missions, some are better suited to specific environments and enemies than others, and we all love those trophies.
Being eaten by giant ants or sucked dry by a mutant spider would be a horrible fate, yes? Luckily the controls in the game are so spot on, you can dodge those giant creatures with ease. Unit movement is handled with the left stick and aiming with the right. This is the only constant as different classes get different functionality for the R and L buttons. As a Ranger I relied heavily on the Shotgun and a ten shot, homing, missile launcher to make mince meat out of those bugs. Controls were tight and easy to pickup, allowing me to hone my skills instead of struggling. Even when I was surrounded like one of the soldiers in Starship Troopers, I stood my ground and laid waste to the hoards of squishy bugs.
The controls carry over very well to the online multiplayer, but sadly the multiplayer feels a bit tagged on. I sat in a waiting room to join some unknown people in battle for about ten minutes before giving up. After starting my own room no one joined me, but the online is basically the campaign with a TON more bugs. I played multiplayer by myself and had to hack my way through hoards of beasts, successfully of course. Going into the multiplayer by yourself may be a bad idea, but if you can get 3 of your friends to join you it would be an amazingly fun time. On top of the multiplayer this game offers split-screen co-op. You basically get four campaigns, one for each class, then five difficulties to tear through, that's well over 50 hours of gameplay, and for the completionist who has to have all the artillery, let's add about ten more hours of bug killing fun.
The story in this game is very "B Movie." Giant bugs have come up from the ground again after being defeated seven years ago, which the first mission lets you know ad nauseum. The story for the most part is told through very short cut scenes as in-game voice overs let you know what events have bearing on the game. As you progress through missions, more story is revealed through radio transmissions and voice overs, and it feels more and more like an old Ed Wood movie. Which is totally fine, I grew up watching THEM! and The Day the Earth Stood Still, so this game was right up my nostalgic alley. If you want a deep, moving story, look elsewhere. This story is more reminiscent of Independence Day than Citizen Kane.
The sound in this game will shake rattle your speakers as the start screen music makes you think you're about to watch anime, and that's perfectly fine with me. This game knows exactly what it is and it embraces it. Sadly, there's very little music during the missions. Seeing as you're destroying bugs and trying to save citizens from a horrible demise, explosions and speech are most prominent. The citizens dialogue is hilarious if limited, but once they quickly die or run away you don't have to hear it anymore. The soldiers have their own voice overs as well. Luckily they change with different missions so you won't hear the same things over and over again, just don't let them get trapped in a giant web, or you will NEVER hear the end of it.
EDF 2025 definitely doesn't have stunning visuals. When you compare it to The Last of Us's lifelike graphics, EDF looks like a PS2 launch game. That lack of visual prowess doesn't take away from the game though. The ants look great, the spiders give you the heebie jeebies, and the city looks like a nice place to live – before you destroy it. The game isn't ugly by any means, just bland and uniform. That may turn off some gamers who have to have 1080p and 180 FPS, but not as much as the lagging framerate. Considering the bland graphics it is stunning that the PS3 can't keep up. Whenever more than four buildings start crashing down, something that happens frequently, the game slows to a crawl. It won't get you killed if you've kept track of enemies on radar, but there's no excuse with how basic the building modeling is. Even if it isn't all smooth sailing it's fun, and if I'm having a great time mowing down bugs it gets my stamp of approval.
Nowadays gamers are looking for a bang for their buck, I know that I am disappointed if I beat a campaign in a little under six hours after spending sixty bucks on a new release, Call of Duty I'm looking at you. So I'm pretty frugal about what I go full price on. I'd happily do so for EDF though. Like I said earlier there are 85 missions to beat, you cannot complete this game in one sitting, and I wouldn't even try that. If you don't like to stray from big publishers you're seriously going to miss out.. If you're like me and enjoy quirky games that may go unnoticed, then EDF 2025 is the gem for you. It strays away from the gritty realistic AAA formula and offers something unique to gamers, an outlandish premise and tight gameplay. Pick this game up and enjoy the non conformist, bug killing action.
Earth Defense Force 2025
Gameplay - 8.5
Story - 7
Graphics - 7
Sound - 7.5
Value - 10
While it may not the prettiest, or most story driven; EDF 2025's gameplay, voicework, and camp appeal make it loads of fun, even more so if you bring a friend.


text: > View Product Details Please select the size of the product. Please enter valid quantity. Donna Karan Dkny New York by Donna Karan for Women overview details Retail: $85.00 Bluefly: $58.00 $58.00 color : We're sorry. This style is sold out. N/A Launched by the design house of Donna Karan in 2002, Dkny New York for Women is recommended for daytime use. Color: N/A Product Category: Fragrance Design House: Donna Karan Introduced In: 2002 Recommended Use: daytime Fragrance Notes: full, rich florals blend to create this popular fragrance. This item cannot be shipped 2nd day air. Allow 1-2 additional shipping days for beauty and fragrance items. This item cannot be shipped outside of the United States. quality material; Imported; style#312499301


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Television Celebrity Ranking
Check out the most updated and latest information about Annie Gill's on the Internet.We have 4 videos of Annie Gill including interviews, events, or public appearances.Annie Gill has over 50 Fans registered on India-Forums.com. We have 26 Television News articles related to Annie Gill.Do share your criticism, comments and feedback for the Actor on Annie Gill's comments page. We have over 7 Photos of Annie Gill to view and download including Annie Gill's Wallpapers.
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Annie Gill u were excellent in siyapaa ishq ka as Krish. U have become a fab actress from anamika due to episodic series. Want to c u in daily series too.
Anni Gill needs to stick to modeling, she is NOT an actress.
Edited on:27 February 2014 at 5:53pm
Grt to noe dat ul b appearing in savdhan india..hope to c u wrk in a daily too..:)
I wish Annie was back in Anamika, I used to watch it only because of her
annie gill...sry i heard u wr a victim of dirty politics..guess wat i hv stoppd watchin d show..evr since ur charactr ws killd:D:D
Annie, Come back soon.. U r superb as Rano..
rano aka annieee!!! comee sooonnn!!!!biggesttt fann of urs!!!:) :)
Hello, Annie Gill. Your role as "Rano" in "Anamika" was awesome! Not because what was the script for her but how you managed to act it. I hope to see you back on the show when you are fully recovered! So get well soon and good luck in future in your career as an actress.
ANNIE DIDI U ROCK i am the biggest fan of u among 43
ur a fabulous actor yar u rock :D
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Oh my, I've never been a fan of Serena but this is finally the season where she outshines Blair... both with looks AND (I never thought I'd say this) personality. I'm beginning to like her very much.
Serena doesnt have large hips.
She has a proper figure. Personally I'm thankful she's not a bean pole.
She looks stunning!
her hips do not look large! ga i wonder what you would say if you saw my hips!!! she looks great and the prettiest i've seen her this season. i hope she starts dressing classier though. she's kind of skanky.
but still SO pretty~
is it me or does that look nothing like serena? i think she looks kind of like kelly clarkson there if you look at it the right way
S is always stunning!!
this dress makes her hips seem a bit large, but she's really beautyful
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- Gossip Girl Season 3 Episode 7: "How To Succeed In Bassness"
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- Serena van der Woodsen
- Related Photos:
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text: I'm 11 DPO, and I tested this morning when I first woke up and got a positive. Later on I took another test, negative, then this afternoon another test, negative again. I plan to test again with the first morning urine tomorrow morning. I wonder if I'm actually pregnant. Anyone experience this before???


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So I've recorded some data from an Android GPS, and I'm trying to find the peaks of these graphs, but I haven't been able to find anything specific, perhaps because I'm not too sure what I'm looking for. I have found some MatLab functions, but I can't find the actual algorithms that do it. I need to do this in Java, but I should be able to translate code from other languages.
As you can see, there are lots of 'mini-peaks', but I just want the main ones.


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Republican Sen. Bob Corker of Tennessee offered a further defense Thursday for being one of only three senators this week to oppose a bill seeking to bolster veterans' health care.
It was a sign of the political sensitivity surrounding veterans' issues because of the recent scandal at the Department of Veterans Affairs.
Corker joined fellow Republican Sens. Jeff Sessions of Alabama and Ron Johnson of Wisconsin on Wednesday in voting against legislation to improve veterans' medical treatment by allowing them to seek care from private doctors. It also enables the VA to move quickly to fire ...


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May I pass along my congratulations for your great interdimensional breakthrough. I'm sure, in the miserable annals of the Earth, you will be
duly inscribed
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Berry Plastics Raises $471 Million Pricing IPO Low End of Range
Berry Plastics Group Inc., the packaging company owned by Apollo Global Management LLC, raised $471 million in its initial public offering, pricing the shares at the low end of the marketed range.
Berry sold 29.4 million shares for $16 each, according to a statement from the company, after offering the shares for $16 to $18 apiece. The stock will start trading today on the New York Stock Exchange under the symbol BERY. The shares sold in the IPO represent a 26 percent stake.
Apollo, which bought Berry in 2006, sought to raise as much as $529.4 million in the offering, giving the company an enterprise value in line with its peers ahead of the IPO, according to data compiled by Bloomberg. Meanwhile, net debt is projected to be $4.1 billion, or 6 times Ebitda, more than twice the level of competitors, the data show. Berry's higher debt load may have given investors pause, even with a valuation similar to rivals, said Todd Wenning of Morningstar Inc.
"Relative to the other players in the field, they stand out as having a higher debt load and little bit more risky balance sheet," Wenning, a Chicago-based analyst, said in a telephone interview before the IPO. "As an investor, if they're trading one-to-one valuation wise, certainly there would be a concern."
Apollo has been seeking to sell its portfolio companies back to the public to return money to clients as it prepares to market a new flagship buyout fund. The New York-based firm expects to start marketing the pool later this year, seeking $10 billion to $12 billion, two people with knowledge of the plans have said.
Apollo, Graham
Ebitda at Berry was $680 million in the 12 months through June 30, filings show. The company also disclosed adjusted Ebidta of $784 million during the period, which excludes charges for restructuring. The IPO price values the company's outstanding common stock at $1.8 billion.
Apollo and Graham Partners Inc., which bought Berry from Goldman Sachs Group Inc. and JPMorgan Chase & Co. in 2006, planned to retain 59 percent and 5.4 percent, respectively, of the company's common stock after the IPO, filings show.
Bank of America Corp., Citigroup Inc., Barclays Plc and Deutsche Bank AG led the sale.


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Call us:
(706) 782-9568
Hillside House
Hillside House
Hillside House
When you want it all, and your plans call for at least a 2 night minimum stay, step up to The Hillside House, a full size house that is sure to please! The Hillside is our newest and largest addition to Mountain Aire Cottage & Inn. This beautiful 3 bedroom, 2 bath split plan home is loaded with all the modern amenities you appreciate, while still maintaining its unique mountain feel.
Start with the solid hickory plank floors that grab your eye and flow throughout the house. Match that with the combination log, and tongue and groove wood walls and you'll say Wow! The Great Room has a full kitchen with island counter, dining area and living/entertainment area with queen size pull out couch. The Master Bedroom has an original King size ornately carved 'pin cone' bed. In the master bath you will find a luxurious Bain Ultra Champagne Bubbler corner tub for 2 with heated back rest, surround by mirrored walls and romantic dimming chandelier! The 5' tall ceramic tile wainscoted walls with heavy torello moldings really accent the rest of the area. A separate shower, vanity, and commode make it complete.
The bedrooms on the other side of the house have been decorated to their own camping and western themes. The Camp Room has a beautiful Queen size bed with ornate "S" moldings, while The Western Room has 2 twin beds for flexible sleeping needs. The 2nd bathroom is a full bath with tub/shower and 5' wainscoted ceramic tile walls and torello modlings. There is a separate laundry room with washer/dryer and laundry tub. Of course there is Central Heat & Air Conditioning, ceiling fans in all the rooms, Cable TV with DVD/VCR player, furnished with dishes, silverware, pots, pans, linens, and initial cleaning supplies, etc.
Outside, you will find a delightful front deck with a view through the dogwoods to Pinnacle Mountain, and large gas grill. The grounds are covered in Azalea's, Dogwood trees, a large White Oak, vibrant dark blue Hydrangea, Rhododendrons, tulips, and so much more! There is parking for up to 5 cars, and only 5 steps to enter the house. Carefully crafted and maintained to your high standards, The Hillside House is for the discriminating guest who wants a quality home to relax in or to entertain their family or friends.
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Huckleberry Cobbler
From EatingWell: July/August 1993
Other berries or combinations of berries, such as blueberries, blackberries or gooseberries, are also excellent in this cobbler. Adjust the sugar according to the sweetness of the fruit.
Makes: 8 servings
Active Time:
Total Time:
Nutrition Profile
Low cholesterol | Low saturated fat | Low sodium | Heart healthy |View Our Nutrition Guidelines »
- 2 pints huckleberries
- 2/3 cup sugar
- 1 tablespoon cornstarch
- 1 teaspoon lemon juice
- 1 1/2 cups all-purpose flour
- 1/4 cup plus 1 teaspoon sugar, divided
- 1 1/2 teaspoons baking powder
- 1 teaspoon baking soda
- 1/4 teaspoon salt
- 1 1/2 tablespoons cold unsalted butter
- 1 teaspoon freshly grated lemon zest
- 3/4 cup buttermilk
- 1 tablespoon canola oil
- Position rack in the center of the oven and preheat to 400°F. Coat a 9-inch deep-dish pie plate with cooking spray.
- To make filling: Combine the huckleberries, 2/3 cup sugar, cornstarch and lemon juice in a mixing bowl. Transfer to the prepared pie plate.
- To make cobbler dough: Whisk together flour, 1/4 cup sugar, baking powder, baking soda and salt in a medium mixing bowl. Cut butter into flour mixture with a pastry cutter or 2 forks until crumbly. Stir in lemon zest.
- Whisk together buttermilk and oil in a small bowl. Make a well in the center of the dry ingredients, add the wet ingredients and stir with a fork until just combined. Turn the dough out onto a lightly floured surface. Roll or pat to a rough 8-inch circle. Gently lift the dough and set it on the berries. Use your fingers to pinch and patch together. (The dough is supposed to look rough and "cobbled.") Prick the dough in several places with the tines of a fork. Sprinkle the top with the remaining 1 teaspoon sugar.
- Bake the cobbler until the fruit bubbles and the dough is golden brown, 25 to 30 minutes. Transfer the cobbler to a rack to cool. Serve warm or at room temperature.
Tips & Notes
- Make Ahead Tip: Equipment: 9-inch deep-dish pie plate
Per serving: 250 calories; 4 g fat (2 g sat, 1 g mono); 7 mg cholesterol; 50 g carbohydrates; 3 g protein; 1 g fiber; 337 mg sodium; 61 mg potassium.
Nutrition Bonus: Folate (17% daily value).
Carbohydrate Servings: 3
Exchanges: 1 starch, 1/2 fruit, 1 1/2 other carbohydrate, 1 fat
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Recipe Categories
- Style/Theme
- Kid-friendly
- Vegetarian
- Birthday
- Entertaining, casual
- Type of Dish
- Baked Goods, other
- Desserts, fruit
- Ease of Preparation
- Easy
- Total Time
- 1 hour or less
- Ethnic/Regional
- American
- Servings
- 8 or more
- Health & Diet Considerations
- Low cholesterol
- Low saturated fat
- Low sodium
- Heart healthy
- Preparation/ Technique
- Bake
- Holiday
- Father's Day
- July 4th
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- Publication
- July/August 1993


text:
Elite Pro Hockey Skate Guards - Senior
Elite Pro Hockey Skate Guards - Senior
Get the EDGE and protect it!
It's all about edge! Keep your skates sharp and protect the edges with ELITE® PRO SKATE GUARD impregnated with VCI. The game of hockey is all about skill, speed, precision and discipline; regular maintenance and care of your skates will help your game and protect your investment.
Which way on your skates does this go? Tag in Front or Back? Rubber Toe cover or Rubber Heel Guard??
By Hockey Mike from Los Angeles on November 17, 2014
By Customer Service on November 17, 2014
Answer:The tag goes in the back, the logo goes in the front.
Just curious about the materal, if it's going to work outdoors?
By Janne from Finland on March 1, 2014
By Customer Service on March 3, 2014
Answer:They are not designed to be worn on the skates as you're walking. They're only designed to be placed on the blades while your skates are in your hockey bag to protect the rest of your equipment from the blades.
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Girls In Yoga Pants @girlsinyogapants
1079 Images
If you don't like yoga pants, you're wrong. GirlsInYogaPants.com was created to show appreciation for the worlds greatest article of clothing. We do not believe that yoga pants make every posterior look good, however, we do believe it enhances a nice posterior to it's fullest potential. Check us out on Twitter @GirlsInYogaPant and Like us on Facebook ! - Girls In Yoga Pants (@girlsinyogapants)


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Originally posted on Single Leg TakeDown:
The SWE Spotlight continues this week with someone that "All Night" Ian Ambrose mentioned in his interview last week, "Mr News". When you have a wrestler called "Mr News", just the name alone creates mystery and intrigue. Luckily enough, he lives not too far from me, so I was able to catch up with the mystery man this past week and talk to him about his career, his ambitions and the work he does for SWE behind-the-scenes, but for those of you who might not be familar with him, here's a bit of background!
View original 2,136 more words


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2000 Ford Expedition • 177,310 miles
I have a 2000 Ford Expedition that the heat does not work. The air works great but when you turn the heater on, it seems as though the air is still on-there is no change in the temp of the air coming through the vents. What could cause this to happen?
September 24, 2012.
September 24, 2012.
The air-mix and venting systems seems to be faulty or stuck and not allowing the proper air delivery. You would need to check the actuator movements etc. Is this an automatic or manual HVAC system?
I'm not actually sure. It is my husbands trucka nd we just bought it 4 days ago. He thinks it is automatic.
Sep 24, 2012.
Sep 24, 2012.
The blend doors are vacuum operated so I would suggest starting by checking the vacuum hoses for leaks.
Well I,m freezing my butt off ! Anyway the heater motor works but it blows out cold air as well as luke warm but when I,m going down the road, there must be a hole somewhere under the ...
10 answers • 1991 Ford Tempo • 150,000 miles
My car heater only just warms up a little when running round town and stays cold on long run .temp gauge says tempreture ok .fan cuts in approx after just half way .coolant in expansion...
1 answer • 1998 Vauxhall Astra • 91,000 miles
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10 answers • 1995 Nissan Altima • 130,000 miles
In my 2007 saturn relay my rear heater works great, but the front heater only blows cold air..... there is plenty of coolant, the heater and a/c works in the back of the vehicle, and ...
5 answers • 2007 Saturn Relay • 68,000 miles


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Animal Communication is a type of telepathy we all share. Have you ever felt your pet is "trying to tell me something"? They are! Be entertained by Reisa's sometimes humorous, sometimes poignant stories.Bring your questions.
Reisa will discuss pets' point of view regarding death, spirituality, behavioral problems, human behavior and family relationships. You'll laugh at her story of a snobbish Papillon who is in a longtime cold war with "the ca-at," and shed tears at the Thoroughbred mare who, as an arthritic senior, finally found her home.
Animal Communication can help resolve behavioral problems by revealing their roots, and relieve rescued pets' anxiety. While it is not a substitute for vet care or training, AC enhances and supports.
Please bring a clear photo of your pet with his or her eyes clearly visible, and no red eye. Your pet may be selected for a reading.
Enter your name in a draw for a Pure Energy Pet Healing. Reisa does most sessions over the phone, so distance is not an issue. Please arrive early to enter and find a seat.
The BC Pet Lover Show is at Abbotsford TRADEX, beside the airport. It's an easy 45 minutes straight out the #1, with signs pointing you to the conference centre.
For more information about the Show, please visit:
For more information about Reisa's services, please visit: http://www.reisastone.com
Don't miss meeting The Real Dr. Dolittle!
Reisa listened to animals all her life. She has groomed and trained horses to national level, managed a stud farm and shown dogs. She rehabs both wildlife and badly abused rescue pets, and was a veterinary assistant. Reisa will also guide you towards training and health resources.


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Anti-smoking campaigns also a reason, but it's cost that keeps many from lighting up
PINAR DEL RIO, Cuba The elderly cigar maker sits at a rustic table next to a tobacco field and a barn filled with hanging rows of aging tobacco and meticulously selects the brown leaves, rolling the most tender ones carefully for the center of the world's most celebrated tobacco product: the Cuban cigar.
But here in the province that's the heart of the tobacco-growing region, as in Havana, it's largely tourists who light up. Very few of the Cubans themselves smoke cigars. The economics of smoking, given the locals' low, government-set salaries, put cigars out of reach for most people, making the iconic Cuban cigar something that's produced for foreigners — for export and for tourism.
Cuban revolutionary leader Fidel Castro, who for years was always puffing on a Cuban Cohiba cigar, gave them up in the mid-1980s. A ferocious anti-smoking campaign by the government in the past 10 years also has had an impact. But it's really about the cost.
Rolando Robaina, a taxi driver from Vinales, a town in the tobacco region, gives his visitors two cigars as a goodwill gesture on a trip from Havana, then offers to sell them more. "I don't smoke," he said.
"The only people I've ever seen puffing on cigars have been in cigar factories, and even in Pinar del Rio, someone might smoke for the theatrical side of things," said Bill Messina, an agricultural economist at the University of Florida who's an expert on Cuba and has been there a dozen times since the 1990s. "It's a luxury good."
John Kavulich, a senior policy adviser with the U.S.-Cuba Trade and Economic Council, said it came down to: "Do you have money for lunch or for a cigar today?"
With salaries that average $17 to $20 a month, even a cigar that costs the equivalent of a dollar in Cuba's currency is out of reach. There are low-quality cigars available for less, but they aren't popular.
Archibald Ritter, a Cuba expert at Ottawa's Carleton University, said that until about 10 years ago cigars were included in every Cuban's monthly ration card — five a month at reduced prices. "People would get the ration and then resell it," Ritter said. "It was sort of an ironic and counterintuitive approach — turning people into mini-capitalists."
Cigars are one of Cuba's few exports, along with nickel, sugar and shellfish, but they've been a constant source of revenue, as well as of pride. "It remains a status symbol," said Jose Azel, a professor at the University of Miami.


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Are you Hajime Nakashima?Claim your profile
Publications (9)60.94 Total impact
Article: 211 Amifostine (Ami) Pharmacokinetics (Pk) in Cancer Patients: Development of A Population ModelTherapeutic Drug Monitoring 09/1997; 19(5):600. DOI:10.1097/00007691-199710000-00221 · 2.38 Impact Factor
Article: Pharmacodynamics and pharmacokinetics of a 72-hour infusion of 9- aminocamptothecin in adult cancer patients[Show abstract] [Hide abstract]
ABSTRACT: To investigate the pharmacokinetics and pharmacodynamics of 9-aminocamptothecin (9-AC) infused over 72 hours at doses of 5 to 74 micrograms/m2/h. 9-AC lactone and total (lactone plus carboxylate) plasma concentrations were measured in 44 patients with solid tumors using a high-performance liquid chromatography (HPLC) assay. Fifteen patients underwent extended pharmacokinetic sampling to determine the distribution and elimination kinetics of 9-AC. At steady-state, 8.7% +/- 4.7% (mean +/- SD) of the total drug circulated in plasma as the active 9-AC lactone. Clearance of 9-AC lactone was uniform (24.5 +/- 7.3 L/h/m2) over the entire dose range examined; however, total 9-AC clearance was nonlinear and increased at higher dose levels. In 15 patients treated at dose levels > or = 47 micrograms/m2/h, the volume of distribution at steady-state for 9-AC lactone was 195 +/- 114 L/m2 and for total 9-AC it was 23.6 +/- 10.6 L/m2. The elimination half-life was 4.47 +/- 0.53 hours for 9-AC lactone and 8.38 +/- 2.10 hours for total 9-AC. In pharmacodynamic studies, dose-limiting neutropenia correlated with steady-state lactone concentrations (Css) R2 = .77) and drug dose (R2 = .71). Plasma 9-AC concentrations rapidly declined to low levels following the end of a 72-hour infusion and the mean fraction of total 9-AC circulating in plasma as the active lactone was less than 10%. The pharmacokinetics of 9-AC may have a great impact on its clinical activity and should be considered in the design of future clinical trials of this topoisomerase I inhibitor.Journal of Clinical Oncology 04/1997; 15(4):1492-501. · 18.43 Impact Factor
- Annals of the New York Academy of Sciences 01/1997; 803(1 The Camptothe):324-6. DOI:10.1111/j.1749-6632.1996.tb26407.x · 4.38 Impact Factor
Article: Phase I and pharmacologic study of 9-aminocamptothecin given by 72-hour infusion in adult cancer patients[Show abstract] [Hide abstract]
ABSTRACT: To conduct a phase I and pharmacologic study of the new topoisomerase I inhibitor, 9-aminocamptothecin (9-AC). A 72-hour infusion of 9-AC was administered every 14 days to 48 solid-tumor patients at doses of 5 to 59 microg/m2/h without granulocyte colony-stimulating factor (G-CSF) and 47 to 74 microg/m2/h with G-CSF. Without G-CSF, two of eight patients who received 47 microg/m2/h had dose-limiting neutropenia in their initial cycle, as did both patients who received 59 microg/m2/h (with a platelet count < 25,000/microL in one). With G-CSF, zero of seven patients treated with 47 microg/m2/h had dose-limiting neutropenia in their first cycle, while dose-limiting neutropenia occurred in six of 14 patients (with platelet count < 25,000/microL in five) entered at 59 microg/m2/h. Among 39 patients entered at > or = 25 microg/m2/h 9-AC with or without G-CSF, fatigue, diarrhea, and nausea/vomiting of grade 2 severity ultimately occurred in 54%, 30%, and 38%, respectively, while grade 3 toxicities of each type occurred in 8% of patients. Steady-state 9-AC lactone concentration (Css) increased linearly from 0.89 to 10.6 nmol/L, and correlated strongly with leukopenia ( r = .85). The recommended phase II dose of 9-AC given by 72-hour infusion every 2 weeks is 35 microg/m2/h without G-CSF or 47 microg/m2/h with G-CSF support. Dose escalation in individual patients may be possible according to their tolerance.Journal of Clinical Oncology 04/1996; 14(4):1236-44. · 18.43 Impact Factor
Article: Bayesian Estimation for TDM of Anticancer Drugs: Evaluation of Different Population Methods[Show abstract] [Hide abstract]
ABSTRACT: Clinical Pharmacology & Therapeutics (1996) 59, 214–214; doi: 10.1038/sj.clpt.1996.355Clinical Pharmacology & Therapeutics 02/1996; 59(2):214-214. DOI:10.1038/sj.clpt.1996.355 · 7.90 Impact Factor
Article: Efficient Sampling Strategies for Forecasting Pharmacokinetic Parameters of Irinotecan (CPT-11)[Show abstract] [Hide abstract]
ABSTRACT: A linear two-compartment Bayesian pharmacokinetic model was developed using a standard two-stage population method for the novel anti-cancer agent CPT-11 from 11 adult patients with refractory cancer. The accuracy and efficiency of this Bayesian model for estimating pharmacokinetic parameters including the area under the concentration-time curve (AUC) was then evaluated using two different sampling strategies in a new study cohort of 13 patients with cancer. Sampling strategies included either one, two, or three nonsteady-state feedback levels determined empirically and from optimal sampling theory (D-optimality). All 24 patients in this study received CPT-11 (60 mg/m2) as a 90-min infusion. Pharmacokinetic parameters derived from the Bayesian model combined with these limited sampling strategies were compared with those parameters obtained from the full sample data sets (n = 10) analyzed by weighted nonlinear least squares regression (reference method). The least-bias and most precise sampling times for estimating AUC were 3.5; 3.5 and 9.5; and 0.5, 3.5, and 9.5 h, respectively. At these times, only marginal improvement in precision of the AUC estimate was observed using two versus three samples. However, the precision of the estimate of clearance was not improved using two versus three samples. The sampling times derived from optimal sampling theory were 0.25, 3.5, 8.5, and 24 h and correlated closely to the actual and best empirical sampling times of 0.5, 3.5, 9.5, and 24 h. These results strongly suggest that Bayesian estimation combined with only two optimally timed samples accurately predicts the AUC of CPT-11 and should be useful for implementing adaptive control dosing for monitoring CPT-11 systemic exposure in patients with cancer.Therapeutic Drug Monitoring 07/1995; 17(3):221-9. DOI:10.1097/00007691-199506000-00003 · 2.38 Impact Factor
Article: A Randomized Cross-over Study of High-dose Metoclopramide plus Dexamethasone versus Granisetron plus Dexamethasone in Patients Receiving Chemotherapy with High-dose Cisplatin[Show abstract] [Hide abstract]
ABSTRACT: We carried out a randomized, single-blind, cross-over trial to compare the antiemetic effect, for both acute and delayed emesis, of granisetron plus dexamethasone (GRN+Dx) with that of high-dose metoclopramide plus dexamethasone (HDMP+Dx). Fifty-four patients with primary or metastatic lung cancer, given single-dose cisplatin (> 80 mg/m2) chemotherapy more than twice, were enrolled in this study. They were treated with both HDMP+Dx and GRN+Dx in two consecutive chemotherapy courses. On day 1, patients experienced a mean of 2.5 (SD = 4.3) and 0.1 (SD = 0.4) episodes of vomiting in the HDMP+Dx and the GRN+Dx groups, respectively (P = 0.0008). Complete response rate on day 1 was 45 and 90% in the HDMP+Dx and the GRN+Dx groups, respectively (P = 0.0001). Patients treated with GRN+Dx had a tendency to suffer more episodes of vomiting than the HDMP+Dx group on days 2-5, but it was not statistically significant. Twenty-four patients (57%) preferred the GRN+Dx treatment and 14 patients (33%), HDMP+Dx. In the HDMP+Dx group, nine patients (21%) had an extrapyramidal reaction, and 5 patients (12%) had constipation that lasted for at least two days. In contrast, no patients had extrapyramidal reactions, and 18 patients (43%) had constipation in the GRN+Dx group (P < 0.01). GRN+Dx was more effective than HDMP+Dx only in preventing the acute emesis induced by cisplatin. An effective treatment for delayed emesis is still needed.Japanese journal of cancer research: Gann 12/1994; 85(11):1151-8. DOI:10.1111/j.1349-7006.1994.tb02921.x
- [Show abstract] [Hide abstract]
ABSTRACT: Paclitaxel, a new antitubular agent, appears to be one of the most promising single agents for the chemotherapy of various solid tumors. The primary objectives of this phase I study of paclitaxel using 24-h continuous intravenous infusions were to determine the maximum tolerated dose of paclitaxel administered by this schedule to Japanese patients with solid tumors and to evaluate the pharmaco-kiiietics of paclitaxel. Eighteen patients received one of five doses of paclitaxel, 49.5, 75, 105, 135 or 180 mg/m2. Prcmedication with diphenhydramine, dexamethasone, and ranitidine was used to prevent acute hypersensitivity reactions. Pharmacokinetic data were obtained from all 18 patients. Dose-limiting toxicities observed at 180 mg/m2 consisted of grade 4 granulocytopenia associated with grade 3 infection. No severe HSRs or cardiac toxicity were detected. Reversible toxicities observed included liver dysfunction, alopecia, peripheral neuropathy and myalgias. Pharmacokinetic studies performed using high-performance liquid chromatography demonstrated that plasma concentrations of paclitaxel increased during the 24-h infusion and declined immediately upon cessation of the infusion with a half life of 13.1-24.6 h (75-180 mg/m2). Less than 10% of paclitaxel was excreted in the urine within 72 h. The peak plasma concentrations and the areas under the concentration-versus-time curves increased linearly with the dose administered. Antitumor activity was observed in one patient with pulmonary metastasis from pharyngeal cancer. Based on these studies a phase II trial dose of 135 mg/m2 administered over 24 h was chosen.Cancer Science 09/1994; 85(10):1057 - 1062. DOI:10.1111/j.1349-7006.1994.tb02906.x · 3.52 Impact Factor
Article: CPT‐11: Population Pharmacokinetic Model and Estimation of Pharmacokinetics Using the Bayesian Method in Patients with Lung Cancer[Show abstract] [Hide abstract]
ABSTRACT: In this study, we aimed to develop a population pharmacokinetic model for CPT-11 and to use the Bayesian method to estimate CPT-11 pharmacokinetic parameters in each of 43 patients who received combined therapy consisting of CPT-11 and etoposide. The group was divided into first and second data sets of 30 and 13 patients, respectively. We developed a population pharmacokinetic model of CPT-11 based on the first data set. The individual pharmacokinetic parameters [area under the concentration curve (AUC) and clearance (CD] were subsequently estimated by using the Bayesian method on the second data set. Plasma CPT-11 concentrations were measured by high-performance liquid chromatography, and compartmental pharmacokinetic models were fitted by the Bayesian method. The population pharmacokinetic model was developed by using the nonlinear mixed effect model. We selected the volume of the central compartment (Vc), CL, and distribution rate constants (K12, K21) as population pharmacokinetic parameters. The population mean values (CV%) of Vc, CL, K12, and K21 were, respectively, 31.8 (15.7%) liter/m2,14.1 (27.8%) liter/h/m2,1.1 (8.4%)/h, and 0.41 (30.3%)/h. Residual intraindivirtual variability was 22.9%. The optimal sampling regime for estimation of the AUC and CL in using the Bayesian method was the two time points of 1 and 8 h post infusion. The mean predictive error, the mean absolute predictive error, and the root mean squared error were -3.3, 9.4, 3.2% (AUC) and 6.3, 10.0, 3.5% (CL), respectively. We concluded that the AUC and CL of CPT-11 could be estimated from plasma concentrations at two times by using the Bayesian method.Cancer Science 08/1994; 85(9):972 - 977. DOI:10.1111/j.1349-7006.1994.tb02977.x · 3.52 Impact Factor
Top Journals
National Cancer Center, JapanEdo, Tōkyō, Japan


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The real question for modern life and reversing language shift is …how one can build a home that one can still call one's own and, by cultivating it, find community, comfort, companionship and meaning in a world whose mainstreams are increasingly unable to provide the basic ingredients for their own members.
(Fishman 1989:16)
This book has addressed questions concerning the rapid decline of linguistic diversity in the Pacific area, and has brought together a rather amorphous body of evidence, much of it quite depressing. We have established that the principal reason for this mass loss of diversity was European colonization, whose agents set in motion a number of processes that have changed the region almost beyond recognition. We have tried to refrain from putting too much emphasis on motifs such as exploitation, selfishness, intolerance and ill will, though all of these were present. Much more importantly, in our opinion, is the sheer ignorance with which the newcomers approached the area and the numerous instances where good intention had unexpected and unwanted long-term effects.
Ignorance of the linguistic situation of the area has been profound and continues to be so. In many areas of life (economic, political, educational and linguistic) expatriate problems and solutions have been imported, distorting local reality and leading to rather costly patch-up jobs when things go wrong. Just as the population and environmental crises have begun to force radical rethinking, the growing realization that there is a cultural and linguistic crisis of equal proportion will no doubt necessitate similar readjustments in this area.
Language planning until the 1980s was based on the premise


text:
So I fitted a generic in car crash cam (collision cam, front facing camera, car camera what ever you want to call it) and when fitting it I found it only came with a cigarette lighter plug. Very annoying when I want to wire it straight to hot power!
after much research it was looking like I needed to buy a piggy back fuse from eBay and an auxiliary cigertte lighter and couple the two together.
How ever!! I went to Halfords today on the off chance they might have another solution and they did! They have just taken delivery of 'Next Base Car Camera Hardware Kit'
This is a piggy pack fuse (comes in both sizes of fuses) coupled to a (what I assume is a voltage regulator) then with a 4 meter mini usb cable! I was pretty amazed as I haven't seen these on the internet!
Fitted the cable as was all up and running in less than 30 minutes! Luckily I already knew the cable route and the trim panels to take off etc!
Still thought I'd let you all know its a brilliant product and I bet they will sell a load to these and its only £10!!
I have no affiliation to Halfords or Nextbase this is only a personal oppinion


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|Liliaceae (lil-ee-AY-see-ee) (Info)
|Lilium (LIL-ee-um) (Info)
|Silk Road
8 - Other hybrids
(b) Out-facing
4-6 ft. (1.2-1.8 m)
12-15 in. (30-38 cm)
15-18 in. (38-45 cm)
USDA Zone 4a: to -34.4 �C (-30 �F)
USDA Zone 4b: to -31.6 �C (-25 �F)
USDA Zone 5a: to -28.8 �C (-20 �F)
USDA Zone 5b: to -26.1 �C (-15 �F)
USDA Zone 6a: to -23.3 �C (-10 �F)
USDA Zone 6b: to -20.5 �C (-5 �F)
USDA Zone 7a: to -17.7 �C (0 �F)
USDA Zone 7b: to -14.9 �C (5 �F)
USDA Zone 8a: to -12.2 �C (10 �F)
USDA Zone 8b: to -9.4 �C (15 �F)
USDA Zone 9a: to -6.6 �C (20 �F)
USDA Zone 9b: to -3.8 �C (25 �F)
Full Sun
Sun to Partial Shade
Fuchsia (Red-Purple)
White/Near White
Mid Summer
6" to 12" (151 mm to 300 mm)
5.6 to 6.0 (acidic)
6.1 to 6.5 (mildly acidic)
6.6 to 7.5 (neutral)
7.6 to 7.8 (mildly alkaline)
By dividing rhizomes, tubers, corms or bulbs (including offsets)
By dividing the bulb's scales
By scoring the base of the bulb to promote new bulblets
From bulbils
Flowers are fragrant
Average Water Needs; Water regularly; do not overwater
This plant has been said to grow in the following regions:
Kenai, Alaska
Lewiston, Idaho
Reubens, Idaho
Sykesville, Maryland
Haydenville, Massachusetts
Bay City, Michigan
West Bloomfield, Michigan
Libby, Montana
Lake Toxaway, North Carolina
Pekin, North Dakota
Coshocton, Ohio
Saylorsburg, Pennsylvania
Fort Worth, Texas
Stafford, Virginia
Kalama, Washington
Whitehall, Wisconsinshow all
On Aug 13, 2009, Chantell from Middle of, VA (Zone 7a) wrote:
First year for me and I wasn't disappointed!! Beautiful contrast in colors and the scent? Delectable!! Definitely has a place at the top of my lily list for scent!!! Holds her form well - so you can enjoy her for days!!!


text:
Herbicides and degradates in shallow aquifers of Illinois: Spatial and temporal trends
Journal of the American Water Resources Association
- By:
- P.C. Mills, D.W. Kolpin, E.A. Scribner, and E.M. Thurman
- The Publications Warehouse does not have links to digital versions of this publication at this time
- Download citation as: RIS
AbstractDuring the fall of 2000, the occurrence was examined of 16 herbicides and 13 herbicide degradates in samples from 55 wells in shallow aquifers underlying grain producing regions of Illinois. Herbicide compounds with concentrations above 0.05 ??g/L were detected in 56 percent of the samples. No concentrations exceeded regulatory drinking water standards. The six most frequently detected compounds were degradates. Water age was an important factor in determining vulnerability of ground water to transport of herbicide compounds. Unconsolidated aquifers, which were indicated to generally contain younger ground water than bedrock aquifers, had a higher occurrence of herbicides (73 percent of samples) than bedrock aquifers (22 percent). Temporal analysis to determine if changes in concentrations of selected herbicides and degradates could be observed over a near decadal period indicated a decrease in detection frequency (25 to 18 percent) between samplings in 1991 and 2000. Over this period, significant differences in concentrations were observed for atrazine (decrease) and total acetochlor (increase). The increase in acetochlor compound concentrations corresponds to an increase in acetochlor use during the study period, while the decrease in atrazine concentrations corresponds to relatively consistent use of atrazine. Changes in frequency of herbicide detection and concentration do not appear related to changes in land use near sampled wells.
Additional publication details
- Publication type:
- Article
- Publication Subtype:
- Journal Article
- Title:
- Herbicides and degradates in shallow aquifers of Illinois: Spatial and temporal trends
- Series title:
- Journal of the American Water Resources Association
- Volume:
- 41
- Issue:
- 3
- Year Published:
- 2005
- Language:
- English
- Larger Work Type:
- Article
- Larger Work Subtype:
- Journal Article
- Larger Work Title:
- Journal of the American Water Resources Association
- First page:
- 537
- Last page:
- 547


text:
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Monaco Government Tourist and Convention Office
7 Upper Grosvenor Street
London W1K 2LX
Tel : +44 (0)207 491 4264
Fax : +44 (0)207 408 2487
For its 20th anniversary, the famous restaurant and bar on Port Hercule is holding a "street party" on Thursday 4 July 2013
The Stars'N'Bars was created in 1993 in an old abandoned warehouse by Kate Powers and Didier Rubiolo, who wanted to create a venue with an American ambiance.
The "Stars" is ideal for families (there's a special room for children, with an activities leader) and has also become a favourite with sports stars (it also has one of the largest collection of items that once belonged to sports celebrities, including Mika Hakkinen's authentic Formula 1 racing car!)
Twenty years later, the Stars'N'Bars is an entertainment complex on three floors. It offers a restaurant and catering service and has a view of the port.
On 4 July 2013, the restaurant will be celebrating both its twentieth anniversary and Independence Day, the American national day.
The Stars'N'Bars will be organising a "street party" for the occasion from 6 pm, with children's activities, American food stalls, a DJ, and more.
There'll be a concert by Joey Fulco and his group the Subway Gunmen Band from Las Vegas.
Free entry, open to all.
Everyone is invited to come dressed "American style."
Full info on: http://www.starsnbarsmonaco.com/fr
Number of views : 417
A Dessert at the Novotel Monte-Carlo to Celebrate the Baptism of the Royal Children
100% French Caught Fish at the Novotel's Restaurant in Monaco
A Focus on Francis Bacon for the Grimaldi Forum Monaco's Major Summer Exhibition
No stress during holidays with Stars N Bars - Thursday December 10th
7 Upper Grosvenor Street
London W1K 2LX
Tel : +44 (0)207 491 4264
Fax : +44 (0)207 408 2487


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Shamin Talks About her Long Break .. And How happy she is to be back on Television . And her Dream Role . Have a look !!!
Added on 11/2/2009
By : tellybuzz
Overall Rating :
Rate Me... Rating Saved!
View : 62043 Comments : 7 Video Courtesy : www.india-forums.com
Popular Search Terms: shamin mannan
Happy to see you back:-)You look great
I dont have colors, will try to catch online.
Thats a sweet interview.
Shamin looks so fabulous! So happy she is finally back on Telly! =)
i used to love her as neha n additi in santaan n bmtd... shes a really good actress.. i loved her couples wid gaurav n mohit
thanks a loot ^^ she''s looking cute ^^
Aww...she's looking so pretty...
Edited on:02 November 2009 at 7:25am
She is sooooo sweet..
awwwwwwwww...........A BEAUTY!!!!!!
waiting for her!!
Look into what happend in 2010. Karan ...
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Madhubala - Ek Ishq Ek Junoon - Promo
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Room 15
See below for a list of paintings in this location
Claude and Turner
Two works by the 19th-century English painter JMW Turner are hung in this room with two by the 17th-century French landscape painter Claude, in accordance with Turner's will.
When Turner died in 1851, he left to the National Gallery Dido building Carthage and Sun rising through Vapour on condition that they were hung 'always between the two pictures painted by Claude', which he named as 'The Seaport' and 'The Mill'.
The pictures within each pair are very different from one another in subject and mood. Turner may have deliberately chosen to make contrasting works so as to mirror the differences between the two pictures by Claude. By doing so, he could also perhaps avoid the sense that he was merely the earlier master's work.
Paintings in this room
The National Gallery, Trafalgar Square, London WC2N 5DN


text:
Lions Gate Rises to 4-Year High on Outlook: Los Angeles Mover
Lions Gate Entertainment Corp., the independent studio that bought the producer of the "Twilight" movies, rose to the highest closing price in more than four years after outlining post-purchase plans.
Lions Gate, based in Vancouver, gained 7.5 percent to $11.84 at the close in New York, the highest closing price since June 2007. The company purchased Summit Entertainment, maker of the "Twilight" series, in January.
The deal gave Lions Gate two teen franchises whose popularity is reflected in book buying and, in the case of "Twilight," in box-office results to date. In March, the studio releases the first of four planned movies from Suzanne Collins's best-selling "The Hunger Games" novels. In November, Lions Gate will distribute the last "Twilight" film, part of a series with $2.5 billion in ticket sales.
"The deal brings together the two premier young-adult franchises," Chief Executive Officer Jon Feltheimer said today on a conference call. "We now have a strong pipeline of franchise property."
Lions Gate is also developing a film based on "Chaos Walking," a young-adult book series by Patrick Ness, and, through the Summit deal, a picture called "Ender's Game," based on the science-fiction novel by Orson Scott Card.
Rob Friedman and Patrick Wachsberger, Summit's co-chairmen, have been named to comparable posts overseeing Lions Gate's motion picture group.


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Nielsen, the purveyor of all things statistical and demographic, published a new study this week on game console usage within the US. According to the report, released on Wednesday, gamers this year spent notably more time streaming video to their consoles than they did in 2010, due in large part to the growing availability of services like Netflix, Hulu, MLB Network and ESPN3. Xbox 360 users spent 14 percent of their console time streaming video this year (compared with ten percent last year), PlayStation 3 owners devoted 15 percent (nine percent in 2010), and Nintendo Wii users spent a whopping 33 percent -- a 13 percent increase over last year's study. Each console, moreover, seems to appeal to different functions. Xbox 360 users, for example, devoted 34 percent of their time to online gaming, Wii owners spent 55 percent of their console time on offline gaming, and the PS3 was the device of choice for DVD and Blu-Ray viewing, comprising 22 percent of usage. Overall, Nielsen found that usage increased by seven percent over the last year across all three platforms, which suggests that streaming may be keeping us glued to our consoles for even longer. Read more at the source link below.
Microsoft Xbox 360
Buy from $200
- Key specs
- Prices
- Discussions
- Game format Optical disc, Downloadable
- Online features Multiplayer, Voice chat, Video chat, Store
- Drive capacity 4 GB
- Controller type Wired, Wireless
- Motion controls Camera / optical
- Video outputs Component, HDMI (v1.4)
- Weight 10.9 lb
- Released 2010-08-03
Nintendo Wii console
Sony PlayStation 3 (late 2012)


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Food-Stamp Bill Would Aid Felons; California Eyes Eligibility for Drug Convicts in treatment.(NATION)
Byline: Cheryl Wetzstein, THE WASHINGTON TIMES
In California and 18 other states, convicted drug felons - including poor mothers - are not allowed to receive food stamps. That policy could change in California, however, if Gov. Gray Davis signs a bill reopening the food-stamp program to drug felons if they are in drug treatment.
"I don't believe we should punish people twice, and if a court finds that a person is in a position to rehabilitate themselves, they should receive benefits," said Democratic Assemblyman Carl Washington, chief sponsor of the bill.
Mr. Davis, also a Democrat, has vetoed two previous bills on this issue, but Mr. Washington thinks his bill - which passed the legislature in late August - will be enacted because it won't cost California any money and would help feed poor adults.
The other bills, Mr. Washington said, would have returned both welfare money and food stamps to drug felons, and California would have had to pay part of the costs of the cash welfare. The food-stamp program is completely federally funded, however, "so there's no cost to the state." Moreover, "food stamps can only be used to purchase food," the assemblyman said, adding that he is personally urging Mr. Davis to sign the bill.
Many Republicans in the Assembly oppose Mr. Washington's bill because they say it will take welfare reform back to the failed policies of rewarding bad behavior.
"It's not OK to use illegal drugs and expect the state to support the habit by also providing food stamps," said Assemblyman Roy Ashburn, lead sponsor of the state's welfare reform measure.
"The bill would send an indefensible message to California's youth that it is acceptable to consume illegal drugs because the state will give them food stamps. This doesn't promote personal responsibility," said Republican Assemblyman Phil Wyman.
The original provision to deny welfare to drug felons was added as a state option by Sen. …


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