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Physical Activity and Body Image of Female Adolescents: Moving toward the 21st Century
Rhea, Deborah J., JOPERD--The Journal of Physical Education, Recreation & Dance
Tremendous strides have been made to involve female adolescents in physical activity and athletics. Since the passage of Title IX (1972) legislation, a number of organizations, including the National Association for Girls and Women in Sport and the Women's Sports Foundation, have identified and publicized the benefits of physical activity and the importance of equal participation of girls and boys. Although these efforts have helped to increase participation in sports and physical activity among females of all ages, two growing trends exist among adolescent females: to become either dramatically more inactive or more involved in extreme dieting behaviors and extensive exercise (Sundgot-Borgen, 1994). These trends are often associated with body image and self-esteem.
Both trends are dangerous, and we, as physical educators and coaches, have the influence to change them. Before a change can be made, it is critical to better understand female adolescents. We know much more about adolescents than we did even two decades ago. This better understanding has come about through research efforts publicized in reports such as Physical Activity and Health: A Report of the Surgeon General (1996) and the report on Physical Activity and Sport in the Lives of Girls from the President's Council on Physical Fitness and Sports (1997). In order to continue increasing the level of participation by girls in sport and physical activity, we must address the issues confronting female adolescents as reported in publications such as these and make the necessary changes to move us successfully into the 21st century.
The purpose of this article is to identify some of the important issues surrounding female adolescents' body image (e.g., puberty, eating disorders, and obesity) and to provide guidelines in the physical education and sport settings that will enhance continued growth of physical activity and sport in the lives of female adolescents.
Psychological Impact of Puberty
In order to support the increase of girls and women in sport and physical activity, we need to understand the impact that growth and development has on adolescent females. As adolescent females reach puberty and start to develop secondary sex characteristics (e.g., breasts and broader hips), their bodies begin to have a higher percentage of fat and their self-esteem begins to diminish. Consequently, studies have shown that adolescent females are generally more negative about their bodies and are concerned with physical beauty and maintaining an ideal, thin shape (as identified by media and societal images) (Galgan & Mable, 1986; Gill, 1995). Studies also report that females spend a great deal of time worrying about how other people will respond to them (Greif & Ulman, 1982). Generally speaking, adolescent females are most concerned about being too tall or too fat, and many well-proportioned young girls may compensate for perceived physical inadequacies by slouching, wearing baggy clothes, or trying a seemingly endless number of fad diets. Individuals with warped body images and the associated low self-esteem lay the groundwork for weight preoccupation and disordered eating.
Body Image and Disordered Eating
One key problem regarding body image lies in the conflict between perception and reality (President's Council on Physical Fitness and Sports Report, 1997). Even when evidence to the contrary shows that females are not overweight, many females perceive themselves to be overweight. Such preoccupation with physique can lead to dangerous attempts to control weight, including excessive levels of physical activity. As Polivy (1994) suggested, "There is a range of compulsiveness connected to physical activity, with some individuals crossing a hypothetical line between what is normal and acceptable and what is destructive or pathological" (p. 883).
Coaches may require workouts that exceed what is considered an acceptable level of activity because of the competitive nature of the sport. …


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June 17, 2003
Will Weatherford commit early?
Gene Williams (Dot Com)
Don't miss your chance to talk serious Seminole football recruiting with the experts on the Warchant.com Premium Recruiting Message Board
There are probably a couple dozen prep quarterbacks that can boast of gaudy passing numbers. However, when it comes to one of the most important stats for judging quarterbacks Drew Weatherford is in a class of his own. The 6-foot-3, 205-pound signal caller had an amazing 37-to-2 touchdown-to-interception ratio last season. That combined with his 70-percent completion percentage and 2,494 passing yards equates to a 159.7 quarterback rating. To put that in perspective the highest single season rating in the NFL is 112.8 by Steve Young in 1994.
What is his secret?
Talk about it on the Premium Recruiting Board or the Regular Recruiting Board
Talk about it in The Main Board
Football Recruiting News
Jones sure of one official visit
BC grabs Texas receiver
Crawford back from Oregon
IMG Day 1: Top performers defense
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subset: commoncrawl


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Bye bye Brady: We laughed and cried (okay, mostly cried) as we said goodbye to our leather-jacket wearing hero. What will Salem do now that Bo isn't around? What ... Read the column now...
2015 Daytime Emmys: Watch exclusive red carpet interviews with your favorite stars Read now...
m. Married
c. Child
a. Affair


text: If shadow detail is not important (and it usually is not for night scenes) then it is easy to push 400TX by 2 or 3 stops. Using a solvent developer like Perceptol will lower the film speed by about a stop. So 400TX can have an EI range from 200 to 3200.


text: As to the staff, they have been friendly and helpful. The room itself was very old fashioned but nevertheless clean. The bed however was clearly past its expiry date. The breakfast was definitely OK but several things were not being repleted so it's a matter of not being too late. I cannot compare with other hotels in Vianden so I... More


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I am trying to post an image to a static page that will span the whole content area (single column content area). Any help would be awesome. Thanks!
I am trying to post an image to a static page that will span the whole content area (single column content area). Any help would be awesome. Thanks!
This is a screen shot from the Hum Theme description. The picture of the light house spans the entire content area. This is the effect I want to achieve.
Please post a link to your site for help with formatting/CSS questions.
unfortunately my site is on a local server right now so there is no link. Is there another way to show you y site?
In your theme's CSS, try:
.page-id-number img{
The ".page-id-number" is written:
".page-id-(put the number of the page you want here - i.e. 2 or 45 or whatever it is)
Thanks for the reply. Unfortunately, it didn't work. As I understand, it doesn't matter where in the CSS I place it, is that correct?
I found this in the CSS code
#content article.format-image .entry-content > :first-child {
margin: 0 -8.96226415%;
max-width: 117.924528%;
width: 117.924528% !important;
padding: 0;
overflow: hidden;
It seems like this can be of some use to me. Any thought?
What theme are you using?
Twenty Eleven, Child Theme: Hum
I don't have 20-11, only the latest 20-12 and 20-13, so I can only go by 20-12's templates and I'm assuming you're using the "content-page.php" template.
In 20-12's CSS (...which may be the same as 20-11's), there is this:
/* Responsive images */
.entry-content img,
.comment-content img,
.widget img {
max-width: 100%; /* Fluid images for posts, comments, and widgets */
...just after it, try:
.page-id-number .entry-content img{
#content {
width: 100%;
margin-left: 0%;
I entered this code below the "Standardize One-Column" section near the top of my CSS sheet for the child theme. Worked nicely.
I also edited these % values
.hentry header {
padding: 1.625em 4% 0;
#content .hentry .entry-content {
padding: 0.6em 4% 0;
border-style: solid;
border-color: #eee;
border-width: 0 0 1px;
Thanks for giving me some ideas. Cheers.
This topic has been closed to new replies.


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Massey Ferguson MF 865 MF 855 Combine Brochure
- Sold for: Start Free Trial or Sign In to see what it's worth.
- Item Category: Advertising
- Source: eBay
- Sold Date: Nov 25,2011
- Channel: Online Auction
For sale is a 4 page Massey Ferguson MF 865 and 855 combine brochure . Form No. ( 502/485/15/1 ) Brochure shows the sales features specifications of the combines.Brochure is in very good condition . Item is sent with cardboard protection. Would rate it a 7.5 out of 10. US Buyers pays $4.00 s/h from Canada. Take advantage of combined s/h costs for multiple purchases. Please check out my Ebay store for more tractor sales lit and manuals. I accept Paypal only. I will ship Worldwide. Canadian buyers must pay GST
Similar Items
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- Pantlind Hotel - Grand Rapids - 1929 - Silver Hot Food Dome Cover Set - Ornate!
- RARE ANTIQUE 1930's CARDUI WOMENS TONIC PORCELAIN SIGN, CHATANOOGA MEDICINE CO.
- BIG SALE Unusual 1986 IN-N-Out Burger Coin (Pewter? Very heavy.)
- Antique 1800's Hog "Slop Fed Pig" N.K. Fairbank Lard Chicago Meat old adv. Card


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Book Discussion on Governor Reagan: His Rise to Power
Journalist and biographer Lou Cannon discussed his latest book on Ronald Reagan, titled Governor Reagan: His Rise to Power, and published… read more
Journalist and biographer Lou Cannon discussed his latest book on Ronald Reagan, titled Governor Reagan: His Rise to Power, and published by PublicAffairs. The book recounts the former president's two terms as governor of California, based on interviews with former staff members, cabinet meeting minutes, and other research. The book traces Reagan's development from political novice to master politician. Mr. Cannon also examines the policies Reagan initiated while in office and his failed 1968 presidential campaign. Following his presentation, Mr. Cannon responded to questions from the audience. close
People in this video
- Lou Cannon Correspondent Washington Post
- Steve Wasserman Editor Los Angeles Times Book Review
Hosting Organization
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Father and son Lou and Carl Cannon were interviewed about their books. Lou wrote Governor Reagan: His Rise to…
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Mr. Cannon talked about his updated paperback biography: [President Reagan: The Role of a Lifetime]. It was…
Valley Girls and Surfer Boys
A panel of native California writers discussed the absurdity of the history and culture of the city of Los…


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My Radio Reel
Here's a collection of some of my favorite executions in my favorite medium, radio.
JUST ADDED: Just found this old spot I did at The Martin Agency in 1985. (Yes, radio had just been invented then, very funny.)
This next one "Crickets," is for Dunwoody, a technical school in Minneapolis that trains young people in the trades; training that will actually land them a job. It was fun working with the sound engineer to create the trill of the cricket's voices.
The next one down is for Norwegian Cruise Line. They wanted to tell folks that NCL docked longer at the Hawaiian Islands, giving customers more time to play.
A demonstration spot for the political coverage of the Minneapolis Star-Tribune.
Another spot for Dunwoody.
National radio spot for Miller Lite beer.
Another Miller Lite spot.
This last one uses original music. I'm always telling writers, "Dude, don't do music" and then I go and do it. Sue me.


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Belle Weather takes bold risk
Eric Cox is hoping that his dreams don't come true. That's right, don't.
"For the last month or so, I can't tell you how much I've woken up in the middle of the night after dreaming about stepping out onto the stage and only 20 people are out there," said Cox, the singer, guitarist and primary songwriter for local, self-described indie rock band the Belle Weather. »Read Full Article(1)
Francesco Lecce-Chong lecture, Gathering of Waters Festival, Herb Fai
In tune
Francesco Lecce-Chong, associate conductor of the Milwaukee Symphony Orchestra, will lead people through Dvorak, Schumann and Elgar Wednesday in a lecture at 5 p.m. in the UWM Fine Arts Recital Hall, adjacent to the music building at 2400 E. Kenwood Blvd. Dvorak's "Slavonic »Read Full Article


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Saturday Aug 23 2008
49ers turn to former Aggie QB
By: Todd Mordhorst Journal Sports Editor
Coach Bob Biggs had mixed feelings about his team's final preseason scrimmage Friday night at Aggie Stadium. But he couldn't hold back a big smile after hearing that former Aggie J.T. O'Sullivan will start at quarterback for the San Francisco 49ers when the NFL regular season begins next month. "I'm just happy for him," Biggs said. "He's worked hard and never really got an opportunity. He's always been in places where they already had a guy (at quarterback). Now he's finally going to get his opportunity and he'll make the most of it. And I think he gives the 49ers the best chance to win, that's the reality of it." O'Sullivan clinched the job with a strong performance during Thursday night's 37-30 exhibition victory over Chicago, and 49ers coach Mike Nolan said it was time to make O'Sullivan's status official after a summer of uncertainty. "J.T. O'Sullivan will be our starting quarterback going into the season and I'm expecting him to succeed," Nolan said Friday. "I'm very confident J.T. is at the point where he's our best man for the job right now." O'Sullivan, a long shot to become the starter when training camp began at the end of July, overtook veteran holdovers Alex Smith and Shaun Hill during the past two weeks. The sixth-year player, now with his eighth NFL team, has never started a regular-season game in the league. That is about to change. O'Sullivan was picked to start San Francisco's preseason opener Aug. 8 against Oakland and has been practicing and playing with the first unit since. He didn't take any snaps in 11-on-11 team drills during the first seven days of training camp as Smith and Hill got all the work. But both players struggled to grasp new offensive coordinator Mike Martz's complex system, and O'Sullivan was given a chance in the lead role earlier this month. O'Sullivan worked in Martz's system last year when both were with the Detroit Lions. He played in four games with the Lions last season and threw the first regular-season passes of his NFL career. He moved the offense during San Francisco's first two preseason games and then had a stellar performance during Thursday's win in Chicago. He completed 7 of 8 passes for 126 yards and guided San Francisco on scoring drives each of his three series. O'Sullivan left the game during the first minute of the second quarter after completing a 37-yard touchdown pass to Jason Hill that gave San Francisco a 13-10 lead. "This hasn't been a case of Alex and Shaun not performing well," Nolan said. "This has been a case of J.T. performing very well. That's why we are where we are. J.T. has very good command of the offense, he's played well in all three preseason games, and now it's time for us to get ready for the regular season." O'Sullivan was drafted in the sixth round of the 2002 draft by the New Orleans Saints. "There were times when J.T. was frustrated, but I said, 'Just hang in there because there's going to be a time when people see the player that you are,'" Biggs said. "So it's nice to see that come to fruition, finally." Nolan said Smith, the team's regular starter the past two seasons, would be O'Sullivan's backup entering the season while Hill would assume the role as the team's No. 3 quarterback. The 49ers invested $24 million in guaranteed money in Smith as part of a $49.5 million deal when they made him the No. 1 overall selection in the 2005 draft. They also signed Hill to a $6 million contract this year after he went 2-0 as a starter last December following injuries to Smith and backup Trent Dilfer. O'Sullivan signed a one-year deal for the veteran's minimum salary of $645,000, but what matters more for the 49ers than those numbers is his performance on the field. "We want to play our best players that give us the best chance to win," Nolan said. "For our football team's sake, it's time to get ready for our opening game. This (decision) puts more focus on where it should be now." The Associated Press contributed to this report.


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Renovations on tap for Albion, Chase Farm parks
Renovations on tap for Albion, Chase Farm parks
LINCOLN - The water-damaged structure that currently sits at the forefront of Albion Park will soon be replaced with a more modern facility as the town continues to upgrade its recreational areas.
Lincoln was one of 26 communities to receive grant money for open space development in the state.
The Rhode Island Department of Environmental Management awarded half of the money toward the $350,000 project to Lincoln, while the voters at the Financial Town Meeting approved the remaining portion.
"From Burrillville to New Shoreham, these grants will allow local communities to invest in our outdoor recreational assets, as well as have the opportunity to upgrade facilities and create local jobs," Gov. Lincoln Chafee said in a press release. "Great parks encourage people to get outside, be active and get healthy. They also showcase the benefits of living in our communities."
According to the grant application, the proposed project will replace the existing 40-year-old wooden restroom and concession facility with three new ADA-accessible restrooms.
In addition, a covered picnic shelter will be constructed onto the building, which will accommodate six tables, and a new park entrance will be designed with paved pathways leading to the picnic shelter and restroom facility.
The existing 4.5-acre park has a baseball field, basketball court, a children's playground area and parking.
Newly paved walkways will be extended to the playground area and basketball court, which will be resurfaced and relined as part of the grant.
Albert Ranaldi, town planner, said the town has been working for 13 years to upgrade its public parks and Albion will be the last place to have its restrooms and concession stands renovated.
"We started in Fairlawn and every other year we received grant funding and we'd tackle another park within the town," he said. "And one of the major elements in these parks is restroom facilities and shading, so our first thing whenever we go to a park is to integrate those features."
Ranaldi said local residents, groups and organizations utilize every park in town, especially during the summer.
Albion Park is a major site for the town's youth playground programs and is used by the town's youth soccer and Little League in the fall, spring and summer.
While the Albion Park project is much larger, Chase Farm Park will also see new restrooms in its future.
The voters at the FTM approved the allocation of $20,000 to match the $100,000 DEM grant awarded to the town for the project.
Two eco-friendly handicap accessible composting toilets will be installed on the property for year-round use.
According to the grant application, the unit's wastewater system is self-contained and does not create any pollution.
The manufacturer of the composting toilets, who will be contracted annually, will be responsible for routine maintenance for the facilities, while the Parks and Recreation Department will clean and stock the units.
Ranaldi said the town got the idea for eco-friendly toilets from DEM officials, who use them in their public parks.
"Usually we put porta-pottys in the park and there's a lot of maintenance to keep them in a presentable form, so this will definitely help the town," he said.
Although the new facilities will allow for year-round use of the park, town officials do not anticipate an increase in maintenance or upkeep.


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The Pantone Color Institute named Radiant Orchid 18-3224 the official color of 2014 (if you are curious how they came to this conclusion, read this) and so I figured I might as well give it a go. JJ was a willing accomplice and the perfect canvas — her warm skin tone is an ideal contrast to the cool tone of orchid.
Make Up For Ever Matte Eyeshadow in 92, $21, available at Sephora; Make Up For Ever Satiny Eye Shadow in 89, $15, available at Make Up For Ever; DiorShow Art Pen, $30, available at Dior; Esqido Mink Lashes in Voila (ethically sourced, meaning they use the natural shedding of minks), $42, available at Esqido; Chanel Le Volume De Chanel Mascara in Noir, $30, available at Chanel; Anastasia Brow Wiz in Brunette, $21, available at Anastasia; Ilia Lipstick in Ink Pot, available at Ilia Beauty; Tom Ford Shade & Illuminate in Intensity #2, $75, available at Neiman Marcus.
La Mer The Moisturizing Lotion, $240, available at La Mer; La Mer The Eye Concentrate, $185, available at La Mer; La Mer The Mist, $60, available at La Mer; MAC Lipstick in Pink Nouveau, $16, available at MAC; NARS Lip Gloss in Triple X, $25, available at NARS; DiorShow Art Pen (used to line the outside edge of the lips), $30, available at Dior; Chanel Le Blanc De Chanel (used to create overall sheen), $45, available at Chanel; Chanel Soleil Tan De Chanel (contour), $48, available at Chanel.
Despite Robin Black's self-professed love/hate relationship with beauty, the photographer-cum-makeup artist behind Beauty is Boring is bent on capturing the faces of everyone from top models to friends to perfect strangers with her vintage Big Shot Polaroid camera, complete with Magicubes & film — after she does their makeup, of course. Get your bookmarks tab ready, ladies.


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When real-estate developer Larry Pina installed an air-tight wood stove several years ago as the primary heat source for his home in Westport, Mass., he found that winter temperatures were varying by an uncomfortable 10 to 15 degrees in different parts of the house. Unhappy with these too-hot and too-cold areas, Pina devised a way to convert his existing gas-fired furnace and its accompanying hot-air ducting into an automatic wood-stove heat-distribution system. The cost of the project was only about $50 for some widely available electrical parts.
Pina replaced the standard heat-only subbase assembly on the gas furnace's room thermostat dial with an interchangeable heat-cool subbase. In addition, he wired a fan relay into the circuit that supplies current to the furnace's blower motor. "Whenever we get a good fire going in the wood stove, we simply switch the new thermostat subbase from 'heat' to 'cool,'" Pina explains. "This disengages the electrical connection to the furnace burners and engages the connection to the new blower relay. As the temperature in the living space rises, the room thermostat opens. This closes the normally open contacts in the fan relay, which turns on the furnace blower but not the gas burners. Hot air from the wood stove is then drawn into the furnace ducts and mixes with colder air from the other rooms. In just a few minutes the whole house equalizes. At that point the temperature at the room thermostat has dropped, so it closes, pulling the fan relay open and shutting off the blower." The wood stove once again warms the living area, restarting the heated-air distribution cycle.
When heated exclusively with the wood stove, all rooms in Pina's three-story house now stay within two to three degrees of each other in temperature. In the summer, Pina also uses the system to mix cool air from the cellar and from a small room air conditioner aimed at the main air-intake duct with the warmer air in the upper floors. The subbase assembly (part Q539A) for the system's T-87 series thermostat and the fan-relay assembly with 24-volt transformer and coil (part R-8239B) are both standard central-air-conditioning-system components. Manufactured by Honeywell, they are sold through heating-supply houses. Sears also sells the same fan relay (Sears part 9211) for $34.99. If no heat-cool subbase is available for your particular thermostat, you will have to invest $30 to $40 for a new one.
Pina says owners of houses equipped with both oil- or gas-fired forced-air heating systems and central air-conditioning systems can use them to circulate heat from a wood stove without making any modifications. By simply turning off the 220-volt circuit breaker in the electrical line to the air-conditioner compressor and setting the heat-cool thermostat to "cool," the existing blowers, ducting, and temperature controls are utilized as an automatic circulation system that "will respond to any heat source,"


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- Oct 4:
- Sotomayor may change court dynamics
- Aug 13:
- Obama throws East Room party for Sotomayor
- Aug 8:
- Sotomayor sworn in as justice
- Aug 7:
- Senate approves Sotomayor, first Latina to Supreme Court
- Denver party gets direct line to congratulate Sotomayor
- Aug 6:
- Sotomayor thanks Denver supporters at LoDo party
- Sens. Udall, Bennet vote 'yes' on Sotomayor
- Senate confirms Sotomayor to Supreme Court, 68-31
- Democrats look to shame GOP on Sotomayor vote
- Jul 29:
- Senate panel approves Sotomayor
- Jul 28:
- Panel Republicans to resist Sotomayor
- Jul 22:
- Panel delays vote on Sotomayor
- Jul 21:
- Udall will vote 'yes' on Sotomayor
WASHINGTON — Republicans will use next week's Senate hearings for Supreme Court nominee Sonia Sotomayor to raise concerns about her record on race, gun rights and abortion while Democrats work to defend President Barack Obama's first high-court choice as a mainstream judge who sticks to the law.
The parties offered glimpses Thursday of their strategies going into the Judiciary Committee hearings that open Monday, announcing witnesses who will testify about Sotomayor.
The Republicans' list of 14 includes New Haven, Conn., firefighter Frank Ricci, a white employee whose reverse-discrimination claim was rejected by Sotomayor in an appellate decision.
Ricci challenged the city's decision to scrap the results of a promotion test because too few minorities scored high enough to qualify. Sotomayor was part of a panel that rejected Ricci's challenge. The Supreme Court reversed that ruling.
Republicans point to Sotomayor's decision as evidence she might let her personal and political views, particularly a belief in racial preferences for minorities, influence her decisions.
Democrats have scheduled Sotomayor's mentors, confidantes and other allies, including several witnesses with GOP credentials. The goal: to portray Sotomayor as a mainstream judge with fans across the ideological spectrum.
Among their 15 witnesses are Manhattan District Attorney Robert Morgenthau, her first boss after law school; New York Mayor Michael Bloomberg, who ran as a Republican but became an independent in 2007; and Louis Freeh, the former FBI director first named to the federal bench by President George H.


text:
This content has been marked as final. Show 5 replies
1. Re: Java apps as natives without jvm preinstallededward17 Feb 7, 2013 8:00 AM (in response to 870611)You can, it does
2. Re: Java apps as natives without jvm preinstalled870611 Feb 7, 2013 9:24 AM (in response to edward17)Sorry, maybe I was not clear...
Idea (not mine and not new) is to pack app with jvm into exe and to launch WITHOUT installing.
Jvm will be kind of 'installed' into operating memory.
3. Re: Java apps as natives without jvm preinstalledsvanimpe Feb 7, 2013 3:42 PM (in response to 870611)I don't know what's the case on Windows or Linux, but building native packages on Mac gives me both a (drag and drop) installer, as well as a directly executable (double click) application. No need to install anything.
4. Re: Java apps as natives without jvm preinstalled870611 Feb 7, 2013 3:51 PM (in response to svanimpe)And I do not know much about Mac. :(
But on windows native installers have to be, hmm, installed, so, issue remains the same.
5. Re: Java apps as natives without jvm preinstalledjsmith Feb 7, 2013 4:23 PM (in response to 870611)zonski was working on an alternate set of JavaFX deployment tools, you may want to leave him a comment on his site or send a message to him to request he incorporate your feature request:
I'm sure he'd appreciate and incorporate a code contribution too :-)
Otherwise to get the feature into the standard deployment tools, log a jira request against the runtime: http://javafx-jira.kenai.com
JavaFX deployment packaging tools are open source:
The JavaFX development source is:
There are also mirrors of the open-jfx repository (including the deployment tools) on bitbucket (as well as a gradel deployment tool) if you prefer to work with them to integrate your idea:


text:
Latest Titles With Casey Affleck
- Job Types
- Movies or TV
- Genres
- Keywords
- IMDb Rating
- Instant Watch Options
- In Theaters
- On TV
- Release Year
1. Untitled Josh Hamilton Project
Drama, Sport | Announced
American baseball player Josh Hamilton, who was a top draft pick in 1999, hits rock bottom after suffering from a drug addiction that ruins his family life and career, only to clean-up his ... See full summary »
Writer: Casey Affleck | Director: Casey Affleck | Star: Jack Reynor
2. To Be Two
Drama | Announced
In a world where people are duplicated and teleported to another planet, a person struggles his his self identity.
Writer: David Lowery | Director: David Lowery | Star: Casey Affleck
3. The Trade (I)
Drama, Sport | Announced
A chronicle of the 1970s scandal caused by New York Yankees pitchers Fritz Peterson and Mike Kekich, who admitted to swapping wives with one another.
Writers: Ben Affleck, Casey Affleck, David Mandel | Director: Jay Roach
4. Boston Strangler
Thriller | Announced
A detective tries to solve the case of a notorious serial killer in Boston during the early 1960s.
Writer: Chuck MacLean | Director: Mark Romanek
5. Far Bright Star
Adventure, Western | Pre-production
Set in 1916, an aging cavalryman leads a team of men to hunt down the Mexican revolutionary Pancho Villa. However, after an ambush in which most of the men are killed, the cavalryman must struggle to survive in the desert.
Writers: Damien Obe, Damien Ober, Robert Olmstead | Director: Casey Affleck
6. Triple 9 (2016)
Crime, Drama | Completed
A gang of criminals and corrupt cops plan the murder of a police officer in order to pull off their biggest heist yet across town.
Writer: Matt Cook | Director: John Hillcoat | Stars: Norman Reedus, Kate Winslet, Teresa Palmer, Gal Gadot
7. The Finest Hours (2016)
PG-13 | Drama, History, Thriller | Completed
The Coast Guard makes a daring rescue attempt off the coast of Cape Cod after a pair of oil tankers are destroyed during a blizzard in 1952.
Writers: Scott Silver, Paul Tamasy, Eric Johnson, Casey Sherman, Michael J. Tougias | Director: Craig Gillespie | Stars: Chris Pine, Ben Foster, Holliday Grainger, Casey Affleck
8. Lewis and Clark (2016 TV Mini-Series)
History | Pre-production
The story of American explorers Lewis and Clarke as they lead a voyage up the Missouri River to the Rockies and down the Columbia River to the Pacific Ocean in 1803.
Stars: Tim Plester, Casey Affleck, William Belleau, Tokala Clifford
9. Manchester-by-the-Sea (2016)
R | Drama | Completed
An uncle is forced to take care of his teenage nephew after the boy's father dies.
Writer: Kenneth Lonergan | Director: Kenneth Lonergan | Stars: Kara Hayward, Casey Affleck, Michelle Williams, Kyle Chandler
10. The Joe Donovan Project (2016)
90 min | Documentary, Biography, Crime | Filming
When he was 17 years old, Joe Donovan was told he would spend the rest of his life in prison. 20 years later, a landmark Supreme Court ruling will change the course of his life once again.
Writer: Jason Pugatch | Director: Jason Pugatch
Lewis and Clark (2016– )
Episode #1.1
Writers: Stephen Ambrose, Michelle Ashford, John Curran, Edward Norton, Derek Robertson | Director: John Curran | Stars: Casey Affleck, Robert Aramayo, Tanaya Beatty, William Belleau
Lewis and Clark (2016– )
Episode #1.2
Writers: Stephen Ambrose, Edward Norton, Derek Robertson | Director: John Curran | Stars: Casey Affleck, William Belleau, Dave Burchill, Tokala Clifford
Lewis and Clark (2016– )
Episode #1.3
Writers: Stephen Ambrose, Edward Norton, Derek Robertson | Director: John Curran | Stars: Casey Affleck, Gerald Auger, Tanaya Beatty, William Belleau
Lewis and Clark (2016– )
Episode #1.4
Writers: Stephen Ambrose, Edward Norton, Derek Robertson | Stars: Casey Affleck, William Belleau, Tokala Clifford, Parker Croft
Lewis and Clark (2016– )
Episode #1.5
Writers: Stephen Ambrose, Edward Norton, Derek Robertson | Stars: Casey Affleck, Gerald Auger, William Belleau, Tokala Clifford
Lewis and Clark (2016– )
Episode #1.6
Writers: Stephen Ambrose, Edward Norton, Derek Robertson | Stars: Casey Affleck, William Belleau, Tokala Clifford, Parker Croft
17. Unity (2015)
99 min | Documentary
Despite the advent of science, literature, technology, philosophy, religion, and so on -- none of these has assuaged humankind from killing one another, the animals, and nature. UNITY is a ... See full summary »
Writer: Shaun Monson | Director: Shaun Monson | Stars: Casey Affleck, Dianna Agron, Malin Akerman, Rick Allen
Votes: 260
18. I Am Dying (2015 TV Movie)
TV-14 | Documentary
Directors: Daniel Lindsay, T.J. Martin | Star: Renee Heidtman
19. Interstellar (2014)
PG-13 | 169 min | Adventure, Drama, Sci-Fi
A team of explorers travel through a wormhole in space in an attempt to ensure humanity's survival.
Writers: Jonathan Nolan, Christopher Nolan | Director: Christopher Nolan | Stars: Matthew McConaughey, Anne Hathaway, Jessica Chastain, Mackenzie Foy
Votes: 777,074
20. Out of the Furnace (2013)
R | 116 min | Crime, Drama, Thriller
When Rodney Baze mysteriously disappears and law enforcement doesn't follow through fast enough, his older brother, Russell, takes matters into his own hands to find justice.
Writers: Brad Ingelsby, Scott Cooper | Director: Scott Cooper | Stars: Christian Bale, Casey Affleck, Zoe Saldana, Woody Harrelson
Votes: 76,836
21. Ain't Them Bodies Saints (2013)
R | 96 min | Crime, Drama, Romance
The tale of an outlaw who escapes from prison and sets out across the Texas hills to reunite with his wife and the daughter he has never met.
Writer: David Lowery | Director: David Lowery | Stars: Rooney Mara, Casey Affleck, Ben Foster, Nate Parker
Votes: 14,725
Real Time with Bill Maher (2003– )
Episode #11.34
TV-MA | Comedy, News, Talk-Show
Writer: T. Rafael Cimino | Stars: Bill Maher, Casey Affleck, Radley Balko, Mattie Duppler
Votes: 15
Jimmy Kimmel Live! (2003– )
Episode #11.82
TV-14 | Comedy, Music, Talk-Show
Writers: Joelle Boucai, Josh Halloway | Director: Payman Benz | Stars: Casey Affleck, Steve Aoki, Shanynn Samiyah Covington, Connor Kalopsis
The Tonight Show with Jay Leno (1992–2014)
Episode #21.193
TV-14 | Comedy, Music, Talk-Show
Writer: Anthony Caleca | Director: Anthony Caleca | Stars: Jay Leno, Rickey Minor, Casey Affleck, Allison Janney
The Tonight Show with Jay Leno (1992–2014)
Episode #22.31
TV-14 | Comedy, Music, Talk-Show
Writer: Anthony Caleca | Director: Anthony Caleca | Stars: Jay Leno, Rickey Minor, Casey Affleck, Kelly Clarkson
Chelsea Lately (2007–2014)
Episode #7.185
TV-14 | Comedy, Talk-Show
In her opening monologue, host Chelsea Handler talks about taking every opportunity to liven up an event, but one event for which she has not been able to do that. Chelsea and her round ... See full summary »
Writers: Fortune Feimster, Sue Murphy | Stars: Casey Affleck, Chuy Bravo, Dov Davidoff, Fortune Feimster
Good Morning America (1975– )
Episode dated 20 November 2013
News, Talk-Show
Stars: Dan Abrams, Casey Affleck, Jim Avila, Abbie Boudreau
Conan (2010– )
I Scream, You Scream, We All Scream Because There's a Murderer on the Loose
TV-14 | Comedy, Music, Talk-Show
Writers: Josh Comers, Dan Cronin, Andres du Bouchet | Stars: Conan O'Brien, Andy Richter, Casey Affleck, Chris D'Elia
Votes: 7
Reel Junkie (2007– )
Out of the Furnace
Creator: Kourosh Taj | Director: Kourosh Taj | Stars: Kourosh Taj, Christian Bale, Woody Harrelson, Casey Affleck
30. ParaNorman (2012)
PG | 92 min | Animation, Adventure, Comedy
A misunderstood boy takes on ghosts, zombies and grown-ups to save his town from a centuries-old curse.
Writer: Chris Butler | Directors: Chris Butler, Sam Fell | Stars: Kodi Smit-McPhee, Anna Kendrick, Christopher Mintz-Plasse, Tucker Albrizzi
Votes: 68,399
Sesame Street (1969– )
Baby Bear Comes Clean
TV-Y | 26 min | Animation, Comedy, Family
Baby Bear is all dressed up and ready to visit Granny when a chance encounter with Telly and a bright purple ice cream cone cause a laundry disaster!
Stars: Casey Affleck, Fran Brill, Tyler Bunch, Leslie Carrara
Votes: 11
32. Tower Heist (2011)
PG-13 | 104 min | Action, Comedy, Crime
When a group of hard-working guys find out they've fallen victim to their wealthy employer's Ponzi scheme, they conspire to rob his high-rise residence.
Writers: Adam Cooper, Bill Collage, Ted Griffin, Jeff Nathanson | Director: Brett Ratner | Stars: Eddie Murphy, Ben Stiller, Casey Affleck, Alan Alda
Votes: 105,004
33. AFI Life Achievement Award: A Tribute to Morgan Freeman (2011 TV Movie)
Writers: Jon Macks, Bob Gazzale | Director: Louis J. Horvitz | Stars: Casey Affleck, Matthew Broderick, Don Cheadle, Delandis
Votes: 39
34. I'm Still Here (I) (2010)
R | 108 min | Comedy, Drama, Music
Documenting Joaquin Phoenix's transition from the acting world to a career as an aspiring rapper.
Writers: Casey Affleck, Joaquin Phoenix | Director: Casey Affleck | Stars: Joaquin Phoenix, Antony Langdon, Carey Perloff, Larry McHale
Votes: 14,327
35. The Killer Inside Me (2010)
R | 109 min | Crime, Drama, Thriller
A West Texas deputy sheriff is slowly unmasked as a psychotic killer.
Writers: John Curran, Jim Thompson | Director: Michael Winterbottom | Stars: Casey Affleck, Kate Hudson, Jessica Alba, Ned Beatty
Votes: 27,485
36. Conan (2010– )
TV-14 | 60 min | Comedy, Music, Talk-Show
Conan O'Brien and his co-host Andy Richter discuss current news topics and interview celebrities and personalities.
Creators: Conan O'Brien, Bruce W. Timm | Stars: Conan O'Brien, Andy Richter, Jimmy Vivino and the Basic Cable Band, Jimmy Vivino
Votes: 15,331
37. WWII in HD: The Air War (2010 TV Movie)
88 min | Documentary, History, War
Follows the incredible stories of three 8th Air Force airmen and Stars & Stripes reporter Andy Rooney during the bloody year leading up to D-Day against the most powerful air force in the ... See full summary »
Writers: Bruce Kennedy, Alec Michod, Liz Reph | Director: Sammy Jackson | Stars: Casey Affleck, Sean Astin, Rob Lowe, Chris O'Donnell
Votes: 105
38. Hollywood Salutes Matt Damon: An American Cinematheque Tribute (2010 TV Movie)
60 min
Matt Damon is roasted, toasted and boasted by his friends, colleagues and co-stars.
Writers: Paul Flattery, David Wild | Director: Michael Dempsey | Stars: Ben Affleck, Casey Affleck, Diane Cardea, Don Cheadle
Votes: 26
The Tonight Show with Jay Leno (1992–2014)
Episode #19.2
TV-14 | Comedy, Music, Talk-Show
Writers: Jay Leno, Jack Coen, Anthony Caleca, Beth Einhorn, Larry Jacobson, Michael Jann, John A. Kennedy, Michael Loprete, Kevin J. Lynn, Jon Macks, Andrew McElfresh, John Melendez, Steve Ridgeway, Michael Riedel, John Romeo, Dave Rygalski, Peter Sears, Jeffrey Spear, Rich Talarico, Troy Thomas, Jim Wise, Rob Young | Directors: Liz Plonka, Anthony Caleca | Stars: Jay Leno, Rickey Minor, Ed Helms, Casey Affleck
Votes: 8
Novum Nieuws Entertainment (2002– )
Kate Hudson: 'Ik vind masochisme wel leuk'
Stars: Casey Affleck, Jessica Alba, Kate Hudson
At the Movies (2004– )
Venice Film Festival 2010
27 min | Talk-Show
David and Margaret look at some of the films shown at the 2010 Venice Film Festival, interview some of their cast and crew and reveal what movies the jury decided were the winners.
Stars: Margaret Pomeranz, David Stratton, Casey Affleck, Darren Aronofsky
42. Plymouth Rock Studios: The Series (2009– )
E | Reality-TV
A real time documentary following the development of the first major studio being built on the east coast.
Stars: Josh Bethoney, Rich Kearney, Casey Affleck, Bob Almond
43. The 80th Annual Academy Awards (2008 TV Special)
TV-14 | 197 min
In the annual awards presentation, the nominated films include Atonement (2007), Juno (2007), Michael Clayton (2007), No Country for Old Men (2007), and There Will Be Blood (2007).
Writers: Rory Albanese, Rachel Axler, Kevin Bleyer, Rich Blomquist, Steve Bodow, Tim Carvell, J.R. Havlan, David Javerbaum, Hal Kanter, Buz Kohan, Rob Kutner, Jon Macks, Sam Means, Jason Ross, Jon Stewart, Bruce Vilanch | Directors: Louis J. Horvitz, Joseph Takats | Stars: Jon Stewart, Jan Aaris, Amy Adams, Casey Affleck
Votes: 1,271
44. The Assassination of Jesse James: Death of an Outlaw (2008 Video)
32 min | Documentary, Short
Explores the true story of the notorious Jesse James, how the myth developed during his lifetime, and how the legends have persisted over 100 years after his death at the hands of his former friend, Robert Ford.
Writer: Skip Robinson | Stars: Casey Affleck, Andrew Dominik, Ralph Ganis, Ron Hansen
Votes: 43
45. Stand Up to Cancer (2008 TV Movie)
Stand Up to Cancer is a ground-breaking television event scheduled to air on September 5, 2008 at 8pm EST and PST... See full synopsis »
Writers: Dave Boone, Jon Macks, Laura Ziskin | Director: Louis J. Horvitz | Stars: Casey Affleck, Jessica Alba, Morgan Andrich, Jennifer Aniston
Votes: 99
46. 13th Annual Critics' Choice Awards (2008 TV Special)
120 min
The Broadcast Film Critics Association annually bestows its awards on the films and film-makers it believes are the best of the year... See full synopsis »
Writer: Adam Vetri | Director: Michael Dempsey | Stars: Casey Affleck, Javier Bardem, Brad Bird, Nikki Blonsky
Votes: 25
47. 13th Annual Critics' Choice Awards Red Carpet Premiere (2008 TV Special)
60 min | Reality-TV
Stars: Carrie Keagan, Sam Rubin, Ross Mathews, Casey Affleck
Votes: 23
48. La noche de los Oscar (2008 TV Movie)
Stars: Àngels Barceló, Jaume Figueras, Cristina Teva, Antonio Muñoz de Mesa
Votes: 7
49. 12th Annual Prism Awards (2008 TV Special)
60 min | Family
The Annual PRISM Awards recognize accurate depictions of drug, alcohol, and tobacco use and addiction in entertainment, including television, feature film, video, music, music videos, and graphic novels.
Writers: Lawrence Scot Deutchman, Brian Dyak | Stars: Casey Affleck, Dave Annable, Danny Arroyo, Andrea Bowen
Votes: 5
The Oprah Winfrey Show (1986–2011)
And the Nominees Are...
Stars: Casey Affleck, Marion Cotillard, Daniel Day-Lewis, Ruby Dee


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Thailand forum
Chang Mai
Joined Travelfish
15th April, 2006
Posts: 10
So finally off next week..
A few questions regarding Chang Mai
Is it cheaper to book hotels over the Internet or when I get there
Should I bring my hiking boots for hikes in and around Chang Mai
#1 Posted: 5/5/2006 - 00:12
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Joined Travelfish
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Location Indonesia
Posts: 7372
Total reviews: 24
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At least 113
Hi woody,
For reservations it depends on the class of hotel -- for the cheap backpacker options, you'll find it cheapest just to show up, but for mid-range and above, take a look around on the never-ending spply of hotel-booking-websites -- some have very low rates.
For hiking boots, i'd go with heavy-duty sandals rather than boots -- not so hot on the feet.
#2 Posted: 5/5/2006 - 06:53
See where I've been in Southeast Asia!
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Posts: 6
Hey Woody,
I've just left Chiang Mai after having spent around five weeks there, on and off. Now, the tourist season there is over, and you'll have no trouble finding a room, and little trouble negotiating for an off-season rate.
I stayed at the Parasol Inn (http://www.parasolinn.com), a new hotel/guesthouse slap-bang-wallop in the middle of the old city - literally at the centre. It has TV/AC (it's VERY hot there now), clean and comfortable rooms, nice staff, you should be able to get between 400 and 600 night for a twin/double. Rooms 2, 3 and 4 01,03 have a view of Wat Chedi Luang from the bathroom window - the bedroom windows are internal to the bathroom. On a Sunday, Chiang Mai's famous walking market is literally on your doorstep.
If you go to the hotel, negotiate down by saying you don't want the free breakfast - food isn't their strong point right now.
I loved staying there, was on first name terms by the time I left, and I couldn't recommend it highly enough.
Somtam's right about the hiking boots - too heavy. But I'd avoid sandals if you're hiking near waterfalls (hopefully you will be!) - the rains have started and there are a lot of leeches around. Get decent lightweight but robust shoes and mesh socks - these will offer you some protection.
Have a fantastic time!
#3 Posted: 6/5/2006 - 12:29
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The (POGO) Blog
July 21, 2014
By Max Johnson
Panelists at Urban Institute Discuss the Art of Watchdogging
POGO Executive Director Danielle Brian spoke on a panel at the Urban Institute about the role of government oversight watchdogs.
Continue Reading Panelists at Urban Institute Discuss the Art of Watchdogging
Topics: Government Accountability
July 11, 2014
A Big Week for the F-35?
The largest defense program in U.S. history—the F-35—is facing two critical events this coming week.
Continue Reading A Big Week for the F-35?
Topics: National Security
June 30, 2014
By Max Johnson
House Report Faults TSA Security Marking in Air Marshal Case
A House Oversight Committee report on the Transportation Security Administration's use of the "Sensitive Security Information" pseudo-classification found that TSA has had "organizational problems" with the application of the SSI designation dating back
Continue Reading House Report Faults TSA Security Marking in Air Marshal Case
Topics: Whistleblower Protections
June 24, 2014
Senator's Report on VA Hospitals Explores Widespread Problems
A new report based on a year-long investigation of the VA healthcare system suggests that problems go far beyond improper scheduling practices.
Continue Reading Senator's Report on VA Hospitals Explores Widespread Problems
Topics: Government Accountability
June 18, 2014
By Neil Gordon
Senators Press Defense Secretary on KBR Litigation
Three senators are demanding answers from Secretary of Defense Chuck Hagel about a long-running legal battle between KBR and National Guardsmen who claim the company exposed them to toxic chemicals in Iraq.
Continue Reading Senators Press Defense Secretary on KBR Litigation
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The League of Women Voters is a nonpartisan political organization encouraging informed and active participation in government. It influences public policy through education and advocacy.
This year our speakers were as follows: JANUARY- David Melton, Executive Director of ICPR (Illinois Campaign for Political Reform), David spoke on Money in Politics and what ICPR is doing to combat this issue. FEBRUARY- Katherine Honeywell, LCSW, director of Social Services, North Shore Senior Center, Katherine's topic was North shore Senior Center- Its diverse offerings and the effects of social service funding cutbacks on programing and services. MARCH- Paula Lawson, Past President of the LWVIL and LWVIL Campaign Finance and Redistricting Issue's Specialist, Paula spoke about Redistricting in Illinois and the need for reform. APRIL- Paddie Brennen, Supervisor of New Trier Township and Miguel Nunez Case Manager of Northfield Township, discussed what the role of Township Government in local Government the relevance of Township Government in today's role. We learned that the townships administer social services to our communities. Conversations continue to be a successful program for the LWVWNK. There were about 20 people that attended each of these programs. The committee is looking forward to 2016 continuation of Conversations.
League of Women Voters Winnetka-Northfield-Kenilworth invites you to attend
"Conversations" is a monthly gathering of League members and their friends who enjoy a mid-day meal followed by stimulating conversation on a variety of important and evolving issues led by experts in the field. All at the Happ Inn, Northfield, 11:45-2:00 pm, $25 a person, pay at the door.
January 20, 2016
February 17, 2016
March 16, 2016
April 20, 2016
We will meet once every two months. Of course, as most of you already know, we welcome all our members to any or all board meetings. We strongly encourage you to come, particularly if you have an issue or interest that you would like us to pursue.
We look forward to a productive and interesting year together.


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Creata Ltd, organisers of the Licensing New Europe Show & Conference, has announced that representatives of Disney Consumer Products (DCP) will be attending this year's event.
Press Release from Creata Ltd
Creata Ltd, organisers of the Licensing New Europe Show & Conference, has announced that representatives of Disney Consumer Products (DCP) will be attending this year's event.
The show, which once again will be held in Zagreb, Croatia, helps to promote the role of licensing in the New Europe region, an area comprising 35 countries and with more than 400 million inhabitants across Central, Eastern and South-eastern Europe, Russia and CIS. Last year's hugely successful event attracted more than 350 participants who took the opportunity to share their experience and knowledge with licensing industry professionals and specialists from New Europe. The show's importance is reflected by the fact that it is the only licensing event in the region that has official LIMA representatives in attendance.
A special section of the show will be dedicated to Disney, where DCP (Central-South European office) executives will be leading workshop sessions entitled 'Basics of licensing' and 'How to license', with specific examples and education about the processes involved. There will also be presentations and screenings of Disney brands, which are being specifically prepared for LNE 2011.
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More details can be found at www.licensingneweurope.com or direct from the organiser at:
Creata LtdPaljetkova 16 HR-10000 Zagreb firstname.lastname@example.com: 385 1 66 08 733f: 385 1 66 08 737


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Yes, well, something smoother and much more easy is what I had in mind. The perfect companion. A quiet walk. A pulled up seat in the back of my car with an old blanket on the floor where Lex would sit nicely and wait until I tell him to get out. Right.
"Lex, please come out of the water. Please come here." Yes, I've gone to begging now from where I've lowered onto the hot sand, dumping loads of it out of my shoes and setting them aside. He only cocks his head and goes on splashing, likely frightening a toad or a fish or whatever he's pawing at.
"Dogs are supposed to be on a leash in public."
I snap my head to the voice behind me. No uniform. Only a man, a perfectly-dressed man with a perfect tan and sun-bleached hair. I'm SO not interested in anything he has to say, unless he shows me a badge. "Thank you for the information." I turn back, now gloating in allowing my adoptee to play freely as he likes. I figure he deserves the play time since I just forced him to the vet's to get his shots and he really was very good there.
"You'll get a fine."
I don't bother looking back again. "Guess that's my problem. Thanks again."
"Does he bite? Because if he bites, that's more than a fine."
"Look." Shooting up to my feet, I've decided I've had enough being walked on by now. "If I get a fine, what do you care? He was on a leash. See?" I hold up the chewed through red string with clasp at one end. "If I can get him back on it again, he'll be on a leash. I may have to walk leaning to one side since there's not much left of it but I'm doing what I can, so back off, Mr. Perfect. I don't want anymore of guys like you."


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text:
August 11th 2008 at 7:55 am
The Borean Tundra is one of two starter zones in Northrend, and can be accessed via the Stormwind Harbor for the Alliance or the zeppelin tower outside of Orgrimmar for the Horde.
Warsong Hold's flight master is at the very top of the massive keep, and she's a lovely tauren lady by the name of Turida Coldwind.
This fellow here, Omu Spiritbreeze, is the flight master for the Horde town of Taunka'le Village. He is, of course, a Taunka. Taunka'le can be found in the northeast arm of the Tundra.
Kara Thricestar is an Alliance flight master at the Fizzcrank Airstrip and yes, another Battlestar Galactica reference.
At the northwest corner of the Borean Tundra you'll find the Bor'gorok Outpost with its flight master Kimbiza at the southeastern edge of town.
Warmage Adami sits astride a Red Drake mount, and will be your Flight Master within the Transitus Shield, tucked away in the Coldarra mountains. This is a neutral flightpath.
Amber Ledge's flight master is missing their skin in the current beta patch, but it's a full grown red dragon by the name of Surristrasz. Since showing you a broken model would be silly, you get to see this rad tapestry inside of a nearby building instead.

Amber Ledge can be found on the western edge of the Borean Tundra, and is the only way to get to the Coldarra at first. Amber Ledge is a neutral settlement, aligned with the Kirin Tor.
Unu'pe is a tuskarr settlment in the eastern reaches of the Borean Tundra, and the goblin Bliko Driftspark will be your flight master. This is a neutral flightpath.
Garrosh Hellscream is in charge of the Horde encampment Warsong Hold, with Saurfang as his much-needed advisor.
Garrosh Hellscream and the Warsong Offensive have made Warsong Hold their base of operations.
It seems the Warsong are more interested in stone than lumber these days. Garrosh Hellscream and the Warsong Clan have completely carved out a field of stone to build Warsong Hold, and have attracted an army of Nerubians in the process.
Another shot of Warsong Hold.
A shot of the Nexus, home of Malygos and the Blue Dragonflight, found in the center of the Coldarra.
A shot of the Nexus, home of Malygos and the Blue Dragonflight, found in the center of the Coldarra.
Mages of the Kirin Tor channel the Transitus Shield to hide themselves from the Blue Dragonflight, right under their noses.
An Arcane Serpent flies past the entrance to the Nexus.
This is a Kvaldir, known as tuk-hariq to the Tuskarr, which means "walkers of the fog". That mist effect you see on the edges of the screen isn't something I added, that is what the area looks like when the Kvaldir are around.
More mist-men.
The Riplash Ruins, formerly a Kaldorei settlement and later taken by the Naga, has recently been taken from them by the Kvaldir.
A mostly intact Tuskarr Monument, unlike the one in the Dragonblight.
Need I say more?
A noble tuskarr warrior astride his turtle mount.
A view of the Geyser Fields from atop the ruins of Talramas.
Parts of the Geyser Fields are having oil issues. Poor birdies.
The Scourge has made The Temple City of En'kilah their stronghold in the Borean Tundra.

Pictured here is a necromancer hard at work.
A stream of nerubian scarabs skitter from one end of En'kilah to the other.
And the ants go marching three by three hurrah, hurrah!
Valiance Keep is the major Alliance outpost in the Borean Tundra. A statue of Varian Wrynn is erected here.
This is a gorloc. The uglier, smarter, more evolved version of a murloc. I don't know how, but I think I like them better than their cousins.
Kel'thuzad keeps the Orcs of Warsong Hold at bay with his legion of undead and Plague Spreaders. It's like fertilizer, but the opposite.

Kel'thuzad is not able to be killed here, and will appear in Naxxramas as well.
You'll first encounter these wooly mammoths in the Borean Tundra, and they're scattered throughout a few other zones, too.
Kirin Tor warmages ride Red Drakes into battle against the Blue Dragonflight.
A shot of the Fizzcrank Airstrip in the northern half of the Borean Tundra.
Wooly rhinos graze on the plains of the Borean Tundra.
Talramas is a crashed necropolis, crunched into the mountains at the northern ridge of the Tundra.
The interior of Talramas. Necromancers work to get the necropolis afloat again.
The PETA parody DEHTA burns an effigy of world famous hunter Hemet Nesingwary.
The Sholazar Basin is just north of the Borean Tundra, but you won't go there for awhile yet. It's a level 76-78 zone, so you'll need to be patient. Pretty though, isn't it?

 That's it for our Borean Tundra preview, but if you're itching for more Wrath of the Lich King eyecandy, check out our Wrath Roundup page or some of our other Wrath galleries, such as our look at the Dragonblight, Utgarde Keep, or the magical kingdom of Dalaran.
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Submited by- Sitagita Team on 09 Feb, 2011 ENTERTAINMENT MOVIES
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Submited by- Sitagita Team on 09 Feb, 2011 ENTERTAINMENT MOVIES
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Submited by- Sitagita Team on 09 Feb, 2011 ENTERTAINMENT MOVIES
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Submited by- Sitagita Team on 09 Feb, 2011 ENTERTAINMENT MOVIES
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Submited by- Sitagita Team on 13 Feb, 2011 ENTERTAINMENT MOVIES
Urrvasi Cinema Hall, Tiruchirappalli is quite a popular and frequently visited movie theater... in the city. Urrvasi Cinema Hall in Tiruchirappalli offers you fine seating arrangements and services... that are sure to impress its viewers and customers. Urrvasi Cinema Hall, Tiruchirappalli puts up a number... of shows of some of the most widely in demand new releases that come to the city. Urrvasi Cinema Hall... among the youngsters and the college going crowd. Urrvasi Cinema Hall is situated in Anna Salai Read More...
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Submited by- Sitagita Team on 12 Feb, 2011 ENTERTAINMENT MOVIES
, Madurai: Show Timings at Mathi Cinema Hall, Madurai Mathi Cinema Hall in Madurai has mid-morning, noon...Mathi Cinema Hall, Madurai is a popular movie theatre in the city of Madurai. Mathi Cinema Hall... to entertainment venues in Madurai. Mathi Cinema Hall, Madurai: Location of Mathi Cinema Hall, Madurai Mathi... Cinema Hall is located in Gnana Olipuram at Arasaradi in Madurai. The movie hall is situated in one... of the busiest parts of Madurai. Mathi Cinema Hall is easily accessible from any part of the city of Madurai Read More...
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Think of a Monday morning. "Gosh! yet another beginning of a work week" is what comes to our...>suffer from the so called Monday morning blues. It is a thing you have in common with the rest.... Some feel it already Sunday evening when the weekend comes to an end. Manic Monday morning... good endorphins. More importantly anticipate your Monday morning on Friday evening itself and make... yourself feel that you are ready for the challenges the Monday morning will bring to you Read More...
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Monday Morning Blues The morning son had filtered in when I had the sounds of footsteps. The maid... bone china cup and saucer. I smiled, but my smile turned into a wail as my dream ended and the morning... of scrabble? Was it Sunday morning when I took my frail and old mother by her hand and set out for my morning Read More...
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the senior designers have been given the impression that a fashion show at a fashion week means emptying your... of audience at this show. Kanadda actors Diganth and Aindrita Ray were the show stoppers of the show. After... was invited to show here." He already has a client base here as he did participate in a few of the menswear Read More...
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Who looks the best with Ranbir?
|Katrina Kaif
|14% | 30 votes
|Deepika Padukone
|79% | 161 votes
|Sonam Kapoor
|5% | 11 votes
|Total Votes: 202
|View all Polls


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November 29, 2015
RENO, NV - Monday's overnight woodburning color code is Red. A burn ban is in effect for all residential, commercial and open burning until air quality conditions improve.
A health advisory has been issued for sensitive groups. This includes children, the elderly, pregnant women, and people with respiratory or cardiovascular disease. People in these sensitive groups are advised to remain indoors when possible and refrain from extended outdoor activities. All others are advised to avoid strenuous outdoor activities.
Remember to call the Air Quality Hotline at 785-4110 before you start a fire.
Click Here to access the online Public Inspection File
Viewers with disabilities can get assistance accessing this station's FCC Public Inspection File by contacting the station with the information listed below. Questions or concerns relating to the accessibility of the FCC's online public file system should be directed to the FCC at 888-225-5322, 888-835-5322 (TTY), or email@example.com.


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Are you Irene Filippi?Claim your profile
Publications (18)60.64 Total impact
Conference Paper: DIFFERENTIAL INFLUENCE OF HYPOXIA ON GENE EXPRESSION OF TUMORAL AND NON TUMORAL MAMMARY CELLSXXXV SISC Meeting, Palermo; 10/2015
- [Show abstract] [Hide abstract]
ABSTRACT: Endometriosis is associated with local angiogenic and hypoxic mechanisms. Indeed, peritoneal fluid of women with endometriosis generates a specific microenvironment to support the growth and development of ectopic endometrial tissues. The association between proangiogenic markers and hypoxic processes in different endometriosis phenotypes was investigated in the present study, analyzing the expression of several genes, related to hypoxic signaling pathway and involved in angiogenic processes, in nonpregnant women with different forms of endometriosis. Samples of ovarian endometrioma (OMA; n = 16) or deep infiltrating endometriosis (DIE; n = 11) were collected, and in addition, control endometrium was collected from healthy women by hysteroscopy. The gene expression of the hypoxia-inducible factors (HIF) 1/2α, protease-activated receptors (PARs) ¼, and vascular endothelial growth factor (VEGF) A was evaluated by quantitative reverse-transcription polymerase chain reaction. Ovarian endometrioma expresses high levels of HIF-1/2α, PAR-1/4, and VEGF-A, while DIE did not show significantly different gene expression compared to endometrium from unaffected women. A positive correlation between the expression of HIF-1/2α and VEGF-A mRNA was observed in OMA. The overall data point out that the heterogeneity of the disease reflects differences in expression levels of genes associated with hypoxia and angiogenesis, suggesting that such conditions may have an active role in the development of the disease.Reproductive sciences (Thousand Oaks, Calif.) 09/2015; DOI:10.1177/1933719115607978 · 2.23 Impact Factor
Article: Short-Term Hypoxia Enhances the Migratory Capability of Dendritic Cell Through HIF-1α and PI3K/Akt Pathway[Show abstract] [Hide abstract]
ABSTRACT: Hypoxia represents an inadequate oxygen supply to tissues, which can modulate cell functions, primarily through the hypoxia-inducible transcription factor HIF-1α. Dendritic cells (DC) are professional antigen-presenting cells and their migration maybe affected by hypoxia, since the local microenvironment in lymphoid organs, as well as in inflamed and tumor tissues, is characterized by low oxygen tensions. In this study we observed an enhanced migratory capability of human monocyte-derived DC, using in vitro migration assays performed under hypoxic conditions. Such enhancement was independent on either the chemoattractants involved or the maturation level of DC. However, HIF-1α appeared to be crucial for the migration only of immature DC and not for mature DC under hypoxia, as indicated by HIF-1α siRNA approaches. Furthermore, we observed that while Akt phosphorylation was enhanced in both immature and mature DC exposed to hypoxia, other signaling pathways, such as p38 and p42/p44 MAPK, were differently affected during hypoxic treatment. More interestingly, aspecific and specific inhibition of PI3K/Akt indicated that such pathway was relevant for the migration of both immature and matured DC under hypoxia, even when DC were transfected with HIF-1α siRNA. Our results indicate that, besides HIF-1α, several other pathways, including PI3K/Akt, may be involved in the response to hypoxia of immature and, more specifically, of mature DC to sustain their trafficking and functions within hypoxic microenvironments. J. Cell. Physiol. 9999: XX–XX, 2014. © 2014 Wiley Periodicals, Inc.Journal of Cellular Physiology 12/2014; 229(12). DOI:10.1002/jcp.24666 · 3.84 Impact Factor
Article: Design, Synthesis, and Biological Evaluation of Pyrazolo[3,4-d]pyrimidines Active in Vivo on the Bcr-Abl T315I Mutant[Show abstract] [Hide abstract]
ABSTRACT: Starting from our in-house library of pyrazolo[3,4-d]pyrimidines, cross-docking simulation was conducted on Bcr-Abl T315I mutant to select new derivatives for biological investigations. Among the selected compounds (2a-e), derivative 2b showed a high activity against the Bcr-Abl T315I mutant (Ki = 36 nM). Binding free energy calculation (MM-GBSA), molecular interaction field (MIF) analysis and free energy perturbation (FEP) studies highlighted the importance of a bromine atom of the para position of the N1 side chain phenyl ring for the interaction with the hydrophobic region I in the T315I mutant. A series of 4-bromo derivatives was thus synthesized and biologically evaluated in cell-free assays (c-Src, Abl wt, Abl T315I mutant) and in the murine myeloid 32D cell lines expressing the human wild type p210-Bcr-Abl or the Bcr-Abl T315I mutant. Compound 2j was identified as the most promising derivative showing a good balance of different ADME properties, high activity in cell-free assays and an interesting sub-micromolar potency against T315I Bcr-Abl expressing cells. In addition, liposome encapsulated 2j was tested on 32D-p210 and 32D-T315I cell lines at concentrations of 0.1 and 1 μM in comparison with the DMSO dissolved 2j. Liposomal formulation increases the solubility of pyrazolo[3,4-d]pyrimidines preserving a good activity on leukemic T315I cells and avoiding the use of DMSO as solubilizing agent. In vivo studies on mice inoculated with 32D-T315I cells and treated for 17 days with 2j showed a more than 50% reduction in tumor volumes when compared to placebo treated mice.Journal of Medicinal Chemistry 06/2013; 56(13). DOI:10.1021/jm400233w · 5.45 Impact Factor
Article: N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a Scaffold for the Synthesis of Inhibitors of Bcr-Abl[Show abstract] [Hide abstract]
ABSTRACT: N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine derivatives were synthesized and evaluated in vitro for their potential use as inhibitors of Bcr-Abl. The design is based on the bioisosterism between the 1,2,3-triazole ring and the amide group. The synthesis involves a copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) as the key step, with the exclusive production of anti-(1,4)-triazole derivatives. One of the compounds obtained shows general activity similar to that of imatinib; in particular, it was observed to be more effective in decreasing the fundamental function of cdc25A phosphatases in the K-562 cell line.ChemMedChem 11/2011; 6(11):2009-18. DOI:10.1002/cmdc.201100304 · 2.97 Impact Factor
Article: Downregulation of Hypoxia-related Responses by Novel Antitumor Histone Deacetylase Inhibitors in MDAMB231 Breast Cancer Cells[Show abstract] [Hide abstract]
ABSTRACT: The tumor microenvironment is characterized by a poor circulation which results in the selection of neoplastic cells that can grow or survive under hypoxic conditions. The relationship between hypoxia and histone deacetylase (HDAC) inhibitors has been previously established. In this work we evaluated the effects of novel HDAC inhibitors (the natural peptide FR235222 and three tetrapeptide analogs) in the human breast cancer cell line MDAMB231, cultured under hypoxia (2% O2 ≉ 14 mmHg) or normoxia (20% O2 ≉ 140 mmHg). First, we found that the novel HDAC inhibitors reduced cell proliferation in MDAMB231 cells at an extent which was similar or even higher than that exerted by the classic HDAC inhibitors trichostatin-A and suberoylanilide hydroxamic acid. More interestingly, the antiproliferative effects of the novel HDAC inhibitors were, in general, significantly higher in hypoxic cells than in normoxic controls. Hypoxic MDAMB231 cells expressed high levels of the hypoxia-inducible factor (HIF)-1α and HIF-1α-related genes, such as vascular endothelial growth factor, Bcl-2/E1B 19 kDa interacting protein-3, glucose transporter-1, carbonic anhydrase IX, as determined by Western blot analysis and qRT-PCR. Finally, we found that HIF-1α and HIF-1α-related genes were significantly downregulated by FR235222 and analogs. In conclusion, the identification of novel effects exerted by the HDAC inhibitors, characterized by a strong efficacy in inhibiting the expression of HIF-1α and its related genes, may have important implications in the pharmacological control of several tumors, including breast cancer, characterized by the presence of hypoxia, angiogenesis and metabolic derangements.Anti-cancer agents in medicinal chemistry 10/2011; 12(4):407-13. DOI:10.2174/187152012800228706 · 2.47 Impact Factor
Conference Paper: Comparative Proteomic Profiling of Normal and Breast Cancer Cells Under Hypoxic Conditions.XXX SISC Meeting.; 08/2011
Article: Role of the Hypoxic Microenvironment in the Antitumor Activity of Tyrosine Kinase Inhibitors[Show abstract] [Hide abstract]
ABSTRACT: The tumor microenvironment is characterized, not only by marked gradients in drug concentration, but also by gradients in the rate of cell proliferation and by regions of hypoxia and acidity, all of which can influence tumor cell sensitivity to drug treatment. Hypoxia is also an important environmental factor in chronic myeloid leukemia (CML), because bone marrow is intrinsically hypoxic in nature. Systems-wide analyses of tumors have recently identified receptor tyrosine kinase coactivation as an important mechanism by which cancer cells achieve chemoresistance. Recent work suggests that Src activation might play a prominent role in the response to hypoxia to promote cell survival, progression, and metastasis of a variety of human cancer. Other studies also established a functional link between Bcr-Abl and the Src family tyrosine kinases. It is well known that mutations can also cause some tyrosine kinases to become constitutively active, a nonstop functional state that may contribute to initiation or progression of cancer as in CML. Leukemic cells carrying chromosomal alteration, are sensitive to imatinib that induces complete remission in most patients. This inhibitor is a highly selective Bcr-Abl tyrosine kinase inhibitor (TKI). There is a considerable interest in understanding how activated signaling pathways enhance tumor cell survival under hypoxia, because this might lead to the introduction of more effective treatments to target these resistant subpopulations. For all these reasons it is important to identify new TKIs which are also active in hypoxia, the real tumor microenvironment, as possible alternative therapy.Current Medicinal Chemistry 06/2011; 18(19):2885-92. DOI:10.2174/092986711796150540 · 3.85 Impact Factor
Article: Design, Synthesis, Biological Activity, and ADME Properties of Pyrazolo[3,4-d]pyrimidines Active in Hypoxic Human Leukemia Cells: A Lead Optimization Study[Show abstract] [Hide abstract]
ABSTRACT: A family of dual Src/Abl inhibitors characterized by a substituted pyrazolo[3,4-d]pyrimidine scaffold was previously reported by us and proved to be active against several tumor cell lines. Among these compounds, a promising antileukemia lead (1) has been recently identified, but, unfortunately, it suffers from substandard pharmaceutical properties. Accordingly, an approach for the optimization of the lead 1 is described in the present work. A series of more soluble pyrazolo[3,4-d]pyrimidine derivatives were rationally designed and proved to maintain the dual Src/Abl activity of the lead. Selected compounds showed an interesting activity profile against three different leukemic cells also in hypoxic conditions, which are usually characterized by imatinib-resistance. Finally, in vitro ADME properties (PAMPA permeation, water solubility, microsomal stability) for the most promising inhibitors were also evaluated, thus allowing the identification of a few optimized analogues of lead 1 as promising antileukemia agents.Journal of Medicinal Chemistry 03/2011; 54(8):2610-26. DOI:10.1021/jm1012819 · 5.45 Impact Factor
Article: Interleukin-1β regulates the migratory potential of MDAMB231 breast cancer cells through the hypoxia-inducible factor-1α[Show abstract] [Hide abstract]
ABSTRACT: The casual relationship between inflammation and tumour progression has been widely accepted and the etiology of breast cancer has been associated with inflammatory processes. Interleukin (IL)-1β, besides its central role in inflammation, has also been recognised as a powerful player in tumour progression, angiogenesis and invasiveness. Recently, there has been considerable interest in understanding the non-hypoxic upregulation of the hypoxia-inducible factor (HIF)-1α by IL-1 in neoplastic cells since aberrant expression of HIF-1α correlates with tumour progression. Here, using the highly invasive human breast cancer cell line MDAMB231, we studied the effect of IL-1β on tumour cell migration along with HIF-1α accumulation. We observed that non-hypoxic induction of HIF-1α by IL-1β in MDAMB231 was associated with increased cell migration, paralleled by upregulation of p38 MAPK phosphorylation and CXCL8/CXCR1 expression. Inhibition of HIF-1α by siRNA resulted in a significant reduction of CXCR1 expression and IL-1β-induced cell migration in MDAMB231 cells, thus confirming a role of HIF-1α in the non-hypoxic-IL-1β-dependent induction of migratory potentials. Our observation that IL-1 induces HIF-1α accumulation in MDAMB231 cells was confirmed in tumour cells growing in vivo using an experimental approach, mimicking the endogenous release of IL-1 in mice bearing MDAMB231 xenografts. Our in vivo data, along with the fact that inhibition of HIF-1α resulted in the decrease of IL-1β-promoted cell migration, further support the link between inflammation and cancer. The overall results may have important implications in those therapeutic approaches aimed to inhibit IL-1-mediated activities in tumour cells, specifically in breast cancer.European journal of cancer (Oxford, England: 1990) 12/2010; 46(18):3400-8. DOI:10.1016/j.ejca.2010.07.044 · 5.42 Impact Factor
Article: Carborane-Conjugated 2-Quinolinecarboxamide Ligands of the Translocator Protein for Boron Neutron Capture Therapy[Show abstract] [Hide abstract]
ABSTRACT: Potential boron neutron capture therapy (BNCT) agents have been designed on the basis of the evidence about translocator protein (TSPO) overexpression on the outer mitochondrial membrane of tumor cells. The structure of the first TSPO ligand bearing a carborane cage (compound 2d) has been modified in order to find a suitable candidate for in vivo studies. The designed compounds were synthesized and evaluated for their potential interaction with TSPO and tumor cells. In vitro biological evaluation showed in the case of fluoromethyl derivative 4b a nanomolar TSPO affinity very similar to that of 2d, a significantly lower cytotoxicity, and a slightly superior performance as boron carrier toward breast cancer cells. Moreover, compound 4b could be used as a ¹⁹F magnetic resonance imaging (MRI) agent as well as labeled with ¹¹C or ¹⁸F to obtain positron emission tomography (PET) radiotracers in order to apply the "see and treat" strategy in BNCT.Bioconjugate Chemistry 11/2010; 21(12):2213-21. DOI:10.1021/bc100195s · 4.51 Impact Factor
Article: 2-Hydroxypropyl-β-cyclodextrin strongly improves water solubility and anti-proliferative activity of pyrazolo[3,4-d]pyrimidines Src-Abl dual inhibitors[Show abstract] [Hide abstract]
ABSTRACT: The main aim of this study was to enhance the solubility of pyrazolo[3,4-d]pyrimidines 1-8 able to strongly inhibit Src and Abl tyrosine kinase phosphorylation in cell-free assays and to significantly reduce leukemic and osteosarcoma cell lines growth, but characterized by very low solubility in aqueous media. Their water solubility was improved between 100 and 1000 folds by solubilization with 2-hydroxypropyl-β-cyclodextrin (HPβCD) and ratio of inclusion complex were determined by phase solubility method. Finally, some complexed compounds were tested on different leukemic (K-652, KU-812 and HL-60) and osteosarcoma (SaOS-2) cell lines showing a good enhancement of biological response in comparison with the not complexed compounds.European Journal of Medicinal Chemistry 10/2010; 45(12):5958-64. DOI:10.1016/j.ejmech.2010.09.062 · 3.45 Impact Factor
- Pigment Cell & Melanoma Research 04/2009; 22(3):335-8. DOI:10.1111/j.1755-148X.2009.00562.x · 4.62 Impact Factor
Article: Identification of a functional role for the protease-activated receptor-1 in hypoxic breast cancer cells[Show abstract] [Hide abstract]
ABSTRACT: Aberrant expression of the protease-activated receptor (PAR)-1 has been associated with tumour progression. Indeed, PAR-1 expression correlates with tumour invasiveness, as well as with cancer cell survival. As the tumour microenvironment is characterised by a low oxygen tension, we decided to investigate the role of PAR-1 in cancer cells exposed to a hypoxic microenvironment. In this study we show that hypoxia enhances PAR-1 expression in MDAMB231 breast cancer cells. We next provided evidence for a novel role of PAR-1 in protecting hypoxic breast cancer against cell death, since inhibition of PAR-1 by RNA interference resulted in a decreased cell survival. Finally, we found that treatment of hypoxic MDAMB231 cells with the specific PAR-1 agonist peptide (TRAP) resulted in a significant increase of cell survival and migration. The overall results identify for the first time a functional role for PAR-1 in the cellular responses of breast cancer to a hypoxic microenvironment.European journal of cancer (Oxford, England: 1990) 12/2008; 45(3):454-60. DOI:10.1016/j.ejca.2008.10.012 · 5.42 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: The ability to maintain O(2) homeostasis is essential to the survival of all invertebrate and vertebrate species. The transcriptional factor, hypoxia inducible factor 1 (HIF-1), is the principal regulator of oxygen homeostasis. Under hypoxic condition HIF-1 induces the transcription of several hypoxia-responsive genes by binding to hypoxia-response elements (HRE) in their promoters. In recent years it has been demonstrated that hypoxia could be related to metabolic variations such as hyper-cholesterolemia in mouse models. On the basis of this observation, the present study was performed to verify the involvement of HIF-1, and in particular the effect of chemical and environmental induction of HIF-1alpha (the oxygen sensitive isoform) accumulation in 3-hydroxy 3-methylglutaryl coenzyme A reductase (HMG-CoAR, the key and rate limiting enzyme of cholesterol biosynthetic pathway) regulation. Our results show that HIF-1alpha accumulation is able to increase level and activity of HMG-CoAR by stimulating its transcription. The raised transcription of the reductase could be related to an induction by HIF-1alpha even if a parallel action of SREBP-2 actively translocated to nucleus by the increased level of SCAP cannot be excluded.Journal of Cellular Biochemistry 06/2008; 104(3):701-9. DOI:10.1002/jcb.21757 · 3.26 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: The ability to maintain O 2 homeostasis is essential to the survival of all invertebrate and vertebrate species. The transcriptional factor, hypoxia inducible factor 1 (HIF-1), is the principal regulator of oxygen homeostasis. Under hypoxic condition HIF-1 induces the transcription of several hypoxia-responsive genes by binding to hypoxia-response elements (HRE) in their promoters. In recent years it has been demonstrated that hypoxia could be related to metabolic variations such as hyper-cholesterolemia in mouse models. On the basis of this observation, the present study was performed to verify the involvement of HIF-1, and in particular the effect of chemical and environmental induction of HIF-1a (the oxygen sensitive isoform) accumulation in 3-hydroxy 3-methylglutaryl coenzyme A reductase (HMG-CoAR, the key and rate limiting enzyme of cholesterol biosynthetic pathway) regulation. Our results show that HIF-1a accumulation is able to increase level and activity of HMG-CoAR by stimulating its transcription. The raised transcription of the reductase could be related to an induction by HIF-1a even if a parallel action of SREBP-2 actively translocated to nucleus by the increased level of SCAP cannot be excluded.
Article: PO37 Hypoxia induces the expression of protease-activated receptor (PAR)-1 through the hypoxic inducible factor (HIF)-1α in MDA-MB-231 breast cancer cellsThrombosis Research 12/2007; 120. DOI:10.1016/S0049-3848(07)70190-1 · 2.45 Impact Factor
Article: Thrombin inhibits IFN-gamma production in human peripheral blood mononuclear cells by promoting a Th2 profile.[Show abstract] [Hide abstract]
ABSTRACT: Thrombin, the key enzyme of the coagulation cascade, is involved in inflammation. It was proposed recently that thrombin activity may play an important role in allergic inflammation. Interferon-gamma (IFN-gamma) is a potent Th1-related cytokine secreted by activated T cells and is usually downregulated in allergic inflammation. We recently demonstrated that thrombin enhances interleukin-10 (IL-10) in peripheral blood mononuclear cells (PBMC). Thus, we hypothesized that thrombin may promote a Th2 profile. We here report that human alpha- thrombin downregulates IFN-gamma expression at both protein and mRNA levels in activated PBMCs. The use of proteolytically inactive thrombin and of the specific thrombin receptor agonist peptide, SFLLRN, shows that this downregulation is thrombin specific and requires thrombin proteolytic activity. The addition of an anti- IL-10 monoclonal antibody (mAb) to thrombin-treated PBMCs abolishes IFN-gamma downregulation, suggesting that thrombin exerts its effect through IL-10, a Th2-related cytokine. Furthermore, IFN-gamma reduction was accompanied by increased IL-4 release, as well as by an increase in the proinflammatory cytokine IL-1. In conclusion, the observation that thrombin affects the production of IFN-gamma (Th1 profile) and IL-4 (Th2 profile) provides further evidence for the role played by thrombin in modulating Th1/Th2 cytokine balance, which could be particularly relevant in allergic inflammation.Journal of Interferon & Cytokine Research 12/2006; 26(11):793-9. DOI:10.1089/jir.2006.26.793 · 2.00 Impact Factor
Top Journals
Università degli Studi di Siena
Siena, Tuscany, Italy
- • Department of Molecular & Developmental Medicine
- • Department of Medicine, Surgery and Neuroscience


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Nice GH4 Camera Rig
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That's one of the only shoulder DSLR rigs I've seen that looked interesting to me... only what looked necessary, and flexible, without that FrankenRig thing you see so often. Thanks for sharing.
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text: MainStoriesIncreasing Healthy Eating Among Special Olympics Athletes Increasing Healthy Eating Among Special Olympics AthletesKarl Hejlik | 10月 04, 2012 | Europe Eurasia: Ireland A Health Promotion resource developed in coordination with Special Olympics Ireland has increased health knowledge and health behaviours, most notably a 48% increase in participants meeting the recommended daily intake of fruits and vegetables, according to report issued Oct. 2. Ireland's Minister of State for Disability, Equality and Mental Health Kathleen Lynch T.D., attended the launch of the report titled "The Development and Evaluation of a Health Promotion Programme for People with Intellectual Disabilities". "It is wonderful to hear how much of a difference it has already made to the participants in such a relatively short period of time. If this programme shows us anything, it is that health and sport go hand in hand and that positive lifestyle changes are important and beneficial to us all," Minister Lynch said. Feedback from participants indicated that the user-friendly nature of the pack ensured that they were more inclined to follow its direction. It was evident that by relating the importance of health to sport, the participants felt more encouraged to make a health change.


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The Nose
Editorial Staff • Edinburgh • 16 Aug 2011
Devised and performed by the young company Fat Git Theatre, and featuring live music, excellent performances and brilliantly original material, this is a fresh and exciting take on absurdist theatre.
Packed full of physicality, symbolism, political and social satire, and a speech about the decapitation of John Gielgud, The Nose is ridiculously free and random, while remaining tightly controlled and considered. This hasn't been devised lightly or stupidly, as so much new absurdist theatre is, but has been carefully constructed resulting in an intelligent and funny finished product.
Fat Git, led by artistic director Joshua Roche, here produces accessible absurdism in a piece that a wide audience will appreciate. To see something completely different and bonkers, The Nose is the best place to start.
- Chris Wheeler
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