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I am blessed!
Oh My Heartsie Reviews, and Pee Dee Mama!
Shining Brightly for All to See
By Traci 3 Comments
Happy Belated Mother's Day! Looks like you are truly blessed!
Thanks for linking up over at Tales of a Pee Dee Mama
I wanted to stop by and thank you for visiting Oh My Heartsie and thanks for sharing m banner with your friends too, thats very sweet!! Hope you have a great night!! Just added ou to my Google + Friends!! Karren
Happy belated Mother's Day!


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At Sittin' Pretty your dog can play, learn, and go home happy and tired. Daycare, boarding, and grooming more
Dog daycare, grooming, overnights. We only take 10 dogs a day to insure individual attention. more
Daily Field Trips, Kennel-Free Boarding, Doggie Daycare with the dinky dogs Social Club, & Grooming in th... more
Offering horseback riding lessons and dressage training to ages 6+ just 5 minutes outside of Portland! more
Premier doggy daycare and overnight boarding facility with a play all day environment. more
Pet sitting, dog walking, litter box refreshing, poop scoop, pet feeding, pet play time, water plants, co... more
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Dog Walking & Dog Training. Exercise and fun all in one. We have a tail wagging good time sniffing out ... more
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subset: commoncrawl


text:
- Activity
- quarter_of_a_number.xbk
- (422 KB, Smartboard)
KS1 quarter of a small number
Introducing how to find a qaurter of a small number. This is a smart notebook file. I use it with Year 2.
3 Reviews
Useful resource, but I couldn't place the pencils in three of the sets as the sets are to the front. When I tried to send them to the back I couldn't. Just a tiny niggle.
This resource explains what a quarter is and shows how you find quarters of different shapes and numbers. Thanks for sharing this useful resource.
Perfect - Just what I need. Clear, simple and makes division/sharing into quarters easy to understand. (will use with Y2) Thanks


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See All Contributors »
Even with the loss to Nebraska we move up to #20 in teh coachs poll
It must have been outstanding win against South Dakota!
NCAA College Basketball Polls, College Basketball Rankings, NCAA Basketball Polls - ESPN
More likely the fact that with a little better offensive performance by just one more player against Nebraska we would have won.
We basically had it down to a 3 pt lead with less than a minute left against the #12 team in the country and we did it while only hitting 2 threes the entire game. Anyone who knows ISU knows that we live by the three, the fact that we only got two during the game and was still in the position to win it in the final minutes says a lot. Compare that to a team that was ranked last week in the AP poll, Kansas, who lost to the worst team in the Big 12 by 24 points.
And that we held a team averaging 80-some points to under 60.
ESPN NCAAW Rankings
the media still thinks ISU is a top 25 team
Last edited by cmoore_23; 01-12-2010 at 07:36 PM.
Iowa State: Anyone who's a true college basketball fan needs to see a game at Hilton Coliseum. Nice is in the DNA of Iowans and the fans here are particularly gracious -- even when the home team loses but gives a great effort, they are appreciative.
ESPN.com picked Hilton Coliseum as the "Hot Arena" in the Big 12...coaches in the league noted that, "regardless of talent, the Cyclones have a home court like no other."
my bad.. I looked in the wbb forum and didn't see it so I didn't know it was posted
Originally Posted by cmoore_23
ESPN NCAAW Rankings
the media still thinks ISU is a top 25 team
Actually the media doesn't, the coaches think we are.
Originally Posted by jaretac
Actually the media doesn't, the coaches think we are.
ya I realized that after I posted it just was hoping no1 noticed
Originally Posted by cmoore_23
ya I realized that after I posted it just was hoping no1 noticed
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Airhead Storm II Towable
The Airhead Storm II Towable give hours of good fun the whole family. Its RF welded 30-gauge PVC bladder assures you utmost quality. You can be assured of extra protection with its rugged, double-stitched 840-Denier nylon cover. The thick front profile allows easy gliding even across big and rough waves. It is designed with a wide wingspan for a comfortable ride. For a safe and enjoyable experience, the product is built with nylon wrapped handles with neoprene knuckle guards. Accomplish easy inflation and deflation by the use of the Boston valve. This valve ensures that the existing sir does not escape. The towable has enough space for two rider. It is portable when deflated, with dimensions of 86 in. x 75 in. The Airhead Storm II Towable is a combination of excitement and adrenalin for a thrilling ride.
This product has a limited warranty of 12 months.
(800) 624-1297


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GNS Foods Parking/GreatNuts.com
2109 E. Division St., Arlington, TX 76011
Parking: Sat, Dec 19 4:25pm + 1hr after event
ParkWhiz worry-free cancellation (cancel anytime up to your start time)
Amenities Included:
Upon arrival, please show your ParkWhiz pass to attendant and they validate your parking.
It is a (.9mi) walk to the Stadium (15-20 min.) We are SOUTHEAST of AT&T/Cowboys Stadium Entrance "E" and Rangers Ballpark/Globe Life Park (.7mi) 1B side or CF on a main throughfare to both Stadi, which is Division Street (TX180). We are an open-air lot with good lighting and security. We have a retail Nut & Candy store Greatnuts.com and Restrooms are available BEFORE the game. We are next door to Liquor Warehouse/SB Food Store
This location is a business.
If you're coming from the EAST, look for the lane signal lights with green arrows. We are just after International Parkway and next To The Liquor Warehouse/SB Food Depot. Enter at the top driveway or turn right on Meridian Street to enter the west side driveway.
If you're coming from the WEST, drive past Stadium Dr and look for us on your left. Turn left on Meridian Street to enter lot.


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This is a press release submitted to the Las Vegas Sun. It has not been verified or edited by the Sun.
Press Release
Las Vegas based insurance agency acquires competitor
Published on Thu, Dec 6, 2012 (1:55 p.m.)Las Vegas, NV December 5, 2012: Guardian Brokers a Las Vegas based insurance agency has completed an acquisition of the assets and clients of HJ Richie & Associates another Las Vegas based agency specializing in insuring Landscapers. Terms of the deal are to remain confidential. Howard "Hap" Richie and his wife Caroline have operated in NV for over 12 years prior to the sell and will be retiring. Marcus Cusick, the 33 year old executive operating Guardian Brokers announces his interest in perpetuating other agencies in the region.
Mr. Cusick commented, "We are pleased to announce the agreement and welcome the clients, employees and insurance carriers of HJ Richie into our organization."
Mr. Cusick also notes that he believes there are other agencies that should be seeking a perpetuation provider, "I believe there are many small agencies owned by partners that are nearing retirement. And most of these do not have a plan that ensures they can exit and be rewarded for what they have built."
Guardian Brokers offers a broad range of insurance and risk management services to businesses, families and non-profits throughout the west. With a focus on providing Legal Malpractice Insurance and Medical Malpractice Insurance the agency has grown and attracted professionals of all kids as clients.
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- Man arrested on DUI count in hit-and-run that killed teen


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Acrex India Mumbaitrade fair for air conditioning and refrigeration
Acrex India is an international exhibition on air conditioning, refrigeration and building services. It will provide an ideal platform for the exchange of ideas among professionals and the opportunity to highlight the latest products, trends and innovations in the industry. Special focus is on products and services for energy efficiency and saving. Target visitors of the fair are air conditioning, refrigeration and heating and ventilation engineers, architects and interior designers, facility managers as well as end users from the private and public sector. Acrex India also includes various technical workshops and lectures on selected subjects.
On the whole the organisers welcomed on the 3 days of the fair, from 26. February to 28. February 2015, about 400 exhibitors from 25 countries and 28000 visitors on the Acrex India in Bangalore.
The Acrex India will take place on 3 days from Thursday, 25. February to Saturday, 27. February 2016 in Mumbai.
25.02.2016 - 27.02.2016*
Thursday - Saturday, 3 days
professional visitors and general public
Western Express Highway
400063 Mumbai, Maharashtra, India
NürnbergMesse India Pvt. Ltd.
2, Nyaya Marg, Chanakyapuri
110021 New Delhi, India
Tel: +91 1147168823
Fax: +91 1126118664
Past events:
26.02.2015 - 28.02.2015
25.05.2012 - 28.05.2012
Fair hotels for
appointment in Mumbai
Only 91 Days ...to Acrex India Mumbai, India
Transfer date to Outlook
Exhibition centres in Mumbai
90518 Nürnberg-Altdorf, Germany
Booth Builders, Exhibition Booth Builders, Exhibition Architecture


text: Michigan Military Rehab Program Welcomes NFL Retirees By Bill Littlefield • Jan 5, 2015 Since 1993, the Eisenhower Center in Ann Arbor, Mich., has been working to rehabilitate veterans of the military who've suffered traumatic brain injuries in combat. Recently, the center's program called After the Impact has also begun serving football players experiencing impairment as a result of concussions or sub-concussive hits. Judge Approves Detroit's Plan To Exit Bankruptcy By Scott Neuman • Nov 7, 2014 Updated at 1:15 p.m. ET A federal judge today gave the OK to a bankruptcy exit strategy proposed by Detroit nearly 16 months after the city asked for protection from its creditors. At a 1 p.m. ET hearing, Judge Steven Rhodes found that the plan was fair and feasible. He's expected to issue a written ruling later. "This city is insolvent and desperately needs to fix its future," Rhodes said. Detroit Bankruptcy Battle Begins In Federal Court By editor • Sep 2, 2014 Detroit's historic bankruptcy case is entering the home stretch. The crucial, final trial phase begins Tuesday in a Detroit courtroom. The trial will decide the fate of a plan to wipe out billions of dollars in debt and help Detroit emerge from bankruptcy as a new, revitalized city. This trial is a big deal, but don't expect anything with lots of courtroom drama. For one thing, it's federal bankruptcy court — and there's no jury. Battling Blight: Detroit Maps Entire City To Find Bad Buildings By editor • Feb 18, 2014 Inside one in a series of abandoned homes along a blighted block of Detroit's Brightmoor neighborhood, filmmaker Tom McPhee walks through the remnants of a life — broken furniture, scattered knickknacks and a flooded basement. "This is fresh water that's coming into the basement here," McPhee points out. "All of that plumbing has been ripped away 'cause someone found a value in it, so they don't care that it's running. This is all over the city." Connecticut Facility Could Lead the Way for Personalized Medicine By Neena Satija • Feb 20, 2012 Governor Dannel Malloy recently committed to investing 291 million of the state's dollars in a new genomic research facility on the Farmington campus at the University of Connecticut. WNPR's Neena Satija reports on what the center can do for medicine and jobs in the state.


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Publisher's Description+
What's new in this version:
- Fix a serious enough bug in ai targeting. The bug caused the AI, in certain situations, to make weird shuffle-doing-nothing moves and not seek enemies or their villages.
- New translations: Shavian.
- Updated translations: Czech, Dutch, Estonian, Finnish, German, Hungarian, Lithuanian, Russian, Serbian, Slovak, Spanish.
- Updated map: The Manzivan Traps
- Removed Elder Wose and Shock Trooper from random_leader of the d... See all new features »


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Today is World Water Day which sounds like something Fuji or Evian�came up with but it is impossibly earnest and deadly serious. We, meaning me as I don't intend to speak for you in matters audacious or aqueous, tend to waste more potable water than drink it every day than most other people�around the world would dare to even use�in a month.
We turn on the tap, let it run and fill a glass though more often than not we grab a plastic bottle from the fridge because tap water is so declasse, unless folks in bottling plants far away are doing just that and then shipping and selling (to us) their tap water. I am a�big fan of capitalism but there's no�one we�won't f*ck for a b*ck, or so it seems.
Considering every carbon based life form on this planet needs water to survive, you'd think today would be a bigger deal in terms of public awareness and news coverage. It isn't and it won't be,�much to the relief�of car wash operators everywhere (and don't get me wrong, I love 'em, too, just not every week)�industrial farms or a lot of folks west of the Rockies. I know, like it would've killed Hallmark to one lousy card, right?
Potable water isn't only life-sustaining and essential, it's a fundamental human right. And those of us who have it, even if our mouths are on the soda as Peter Gabriel noted decades ago, would do well-actually far better than well-to work to make sure everyone, everywhere has water they can drink. Otherwise the thirst for fairness, justice and human dignity�will be overtaken by an unquenchable desire to satisfy one of Maslow's hierarchy of needs�at any cost. And that may be a price none of us can pay.
-bill kenny


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Forget password?
Remember Me
"Lets get this straight... I am a solo artist, but I have a band," Walker writes on his MySpace page.
The glam rock-influenced The Rise & Fall Of Butch Walker And The Lets Go Out Tonites is his third solo release and follows 2004's Letters.
"My last record was the guy in the corner of the bar, crying in his beer because his girlfriend dumped him the night before," Walker told...


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Hotels, restaurants and stores are gearing up to welcome the thousands of visitors who will flood Newport from May 5-17, for the Volvo Ocean Race and the race stopover. Teams competing in the race, a journey of some 40,000 nautical miles making 11 … more
By Nancy Kirsch | Contributing Writer | 3/20/15
Passenger traffic at T.F. Green Airport dropped in February by 5.7 percent, the R.I. Airport Corporation reported Friday. more
By Lori Stabile
With a 2.1 percentage point decline, the Providence-Warwick metropolitan area had the largest year-over-year unemployment rate decrease among metropolitan areas with a population of 1 million or more in January, according to the federal Bureau of Labor Statistics. more
By PBN Staff
When it comes to U.S. economic growth, wages may never have been this important. more
By Victoria Stilwell
Employment increased in 306 out of the 339 largest counties in September, and Providence was no exception with 1.8 percent growth, according to the federal Bureau of Labor Statistics. more
By PBN Staff
New Media Investment Group Inc., whose subsidiary Gatehouse Media owns The Providence Journal, recently completed the previously announced acquisition of substantially all of the assets of Stephens Media LLC for $102.5 million in cash, subject to working capital adjustments. more
By PBN Staff
Americans' outlooks for the U.S. economy dimmed in March from a four-year high as feeble wage gains and harsh winter weather weighed on sentiment. more
By Victoria Stilwell
Fewer than 300,000 Americans filed applications for unemployment benefits for a second week, signaling the labor market remains strong. more
By Shobhana Chandra
The plunge in oil that drained energy shares was also supposed to boost disposable income for consumers. Companies from automakers to retailers are still waiting to see that trickle down to their bottom lines. more
By Joseph Ciolli
A Boston Olympics in 2024 could generate $5 billion in economic activity for Massachusetts from the operations of the games, as well as $4 billion in new construction in the six years leading up to the event, according to a study of Boston's Olympics bid by UMass Donahue Institute researchers. more
By PBN Staff


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VISTA, Calif. (AP) -- A judge is expected to rule Wednesday on whether to unseal search warrants in the investigation into the death of a Camp Pendleton Marine's wife whose body was found near a Southern California lake in April.
San Diego County Superior Court Judge Runston Maino planned to issue his decision at a hearing Wednesday in Vista, Calif.
Ten news organizations, including The Associated Press, are seeking access to at least 18 warrants in the investigation. The warrants were approved by judges in three different courthouses.
Three roommates have pleaded not guilty to murder: Louis Ray Perez, Jessica Lynn Lopez and Dorothy Maraglino. Prosecutors say 22-year-old Brittany Killgore disappeared after agreeing to go on a dinner cruise with Perez, who is also a Marine.
Investigators have not revealed a possible motive for the killing.
U-T San Diego obtained a suicide note from Lopez, who turned 25 on the day Killgore disappeared. Lopez was found by paramedics four days later in a San Diego motel with what authorities called minor, self-inflicted cuts.
In the note, Lopez describes grabbing Killgore's ankle when she entered their Fallbrook home, slamming her into the stairs, shooting her with a stun gun and strangling her with a rope. Lopez wrote that she drove to the beach to dump handcuffs and a knife in a portable toilet, according to the newspaper. She claimed she drove to the lake to dispose of Killgore's body.
See photos relating to this case:
This image provided by the San Diego County Sheriff's Department shows Brittany Dawn Killgore who was reported missing Saturday, April 14, 2012. Killgore, 22, was last seen on Friday and her cellphone was found Saturday in San Diego's Gaslamp District. Sheriff's deputies in San Diego County are searching for a Kilgore, and say it is likely foul play is involved. (AP Photo/San Diego County Sheriff's Department)
Jessica Lynn Lopez, right, is led out of court by a bailiff after her arraignment Thursday, April 19, 2012, in Vista, Calif. Lopez, 25, could face a maximum sentence of life in prison if convicted of killing 22-year-old Brittany Dawn Killgore, whose body was found April 17th in brush near a Southern California lake. (AP Photo/Gregory Bull)
Brittany Killgore's lived near the Camp Pendleton Marine compound in California. Her husband was deployed in Afghanistan at the time of her murder.
San Diego County District Attorney Bonnie Dumanis speaks at a news conference Thursday, April 19, 2012, in San Diego. Authorities have determined that a body found near a Southern California lake is that of Brittany Dawn Killgore, a Marine's wife whose disappearance has led to the arrest of another woman on suspicion of murder. (AP Photo/Gregory Bull)
Jessica Lynn Lopez was arrested at a Ramada Inn near the San Diego airport after a would-be suicide note she wrote gruesomely detailed how she slammed Killgore's body into the stairs, shot her with a stun gun and strangled her with a rope.
A person familiar with the case confirmed the note's descriptions to The Associated Press. That person spoke on condition of anonymity because the note remains under seal by a judge's order.
The judge held off last week on ruling, saying he had not read all the search warrants yet.
Perez's attorney, Jeff Reichert, told the judge then that he supported unsealing the warrants. At a hearing before another judge in April, he said Lopez's note shows "very, very clearly" that she killed Killgore and that his client was not involved.
Lopez's attorney, Sloan Ostbye, has said that she wanted the warrants to remain sealed. Maraglino's attorney, Sean Leslie, said at last week's hearing that he couldn't take a position because he hadn't read all of the warrants.
The San Diego County district attorney's office argued that unsealing the documents may jeopardize the defendants' right to a fair trial, damage an ongoing investigation and violate the victim's privacy.
Guylyn Cummins, the attorney representing the news organizations, said in her motion that speculative fears about pre-trial publicity does not stand as an argument for keeping the warrants sealed, especially in a city with a jury pool as large as San Diego's.
"The media is unaware of any compelling interest that has been demonstrated by anyone to support secrecy of the search warrants in this case," she said.
All three defendants were being held on $3 million bail. A preliminary hearing was scheduled for Aug. 21.
Associated Press writer Elliot Spagat in San Diego contributed to this report.


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Victoria Beckham Not Showing at London Fashion Week; The Row Likely Showing in Europe Again
>> Despite newspaper reports to the contrary — yesterday's Evening Standard cited a source saying that Victoria Beckham "will be working hard over the next month to get everything ready for London Fashion Week" — a British Fashion Council spokesperson confirmed today that Victoria Beckham "is not showing in London this season." In fact, she's listed on the Fall 2011 New York Fashion Week calendar on Sunday, Feb. 13, for her usual presentations by appointment. Meanwhile, we're hearing that another celebrity line, Mary-Kate and Ashley Olsen's The Row, which was originally slated to show in New York last season before canceling and decamping to Paris, is likely going to continue to show in Europe for the upcoming season. [Vogue UK]
Ashley Olsen
Victoria Beckham
The Row
POPSUGAR, the #1 independent media and technology company for women. Where more than 75 million women go for original, inspirational content that feeds their passions and interests.


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2001 Mazda Protege • 127,000 miles
I was getting oil in my overflow and had the head gasket check and it was warped. It was repaired and replaced and I am still getting oil into my overflow. I checked the radiator and there is no oil in it yet until I start driving and then the oil from the overflow gets into my radiator. Is there any other way beside the head gasket that oil is getting into my overflow. I had the block checked and there were no problems.
January 2, 2013.
January 2, 2013.
Was the cooling system cleaned after repairs? It could be residual oil in system. Are you still getting overheating and coolant losses issues now? Is there any sign of coolant in engine oil?
The cooling system was cleaned. I am not having any problems with my car overheating and no coolant in the oil, only in the overflow. I have had no problems with fluid loss.
I noticed the oil in overflow when I checked my oil. This was the only problem I had before I had my head gasket checked was oil in overflow.
I noticed the oil in overflow when I checked my oil. This was the only problem I had before I had my head gasket checked was oil in overflow.
If oil is present in the overflow and not the radiator, that does not make sense if it is from the engine because any fault with the engine would have oil in radiator and coolant as well.
How many times was the recovery tank cleaned and was it thorough?
How much oil is present?
How many times was the recovery tank cleaned and was it thorough?
How much oil is present?
I checked my overflow the other day and oil was present I checked the radiator and could not see any presence of oil. I cleaned out the overflow and replaced it with new antifreeze. I do not understand why when I check my overflow after I have been driving and let it cool that there is oil in the overflow. I then check the radiator to find no oil or only a trace of oil. I believe the shop only cleaned the radiator once. The overflow has a oil ring around the outer edges which you can see as soon as you open up the overflow tank. I will check when I get home tonight to see if I have oil in overflow after being cleaned out again.
Should I have my radiator flushed again or can the head gasket still be leaking.
Should I have my radiator flushed again or can the head gasket still be leaking.
I won't jump to conclusion too quickly if everything is working correctly now. If oil is present, have it cleaned and monitor the situation for a while longer. Let the shop knows about it. Sometimes it needs a few cleaning sessions as residual oil in cooling system needs some time for them to be purged out.
I cleaned out the overflow tank and checked it the next day and there was oil in my overflow so I checked the radiator and it had a grayish looking film on top of antifreeze and some dark oil spots. Is there any other place oil can be getting into my radiator besides the head gasket?
Jan 10, 2013.
Jan 10, 2013.
Yes, a cracked cylinder head is the most likely cause if you do not have pressure in system.
Jan 22, 2013.
Jan 22, 2013.
NEED some advice and help. 1996 GMC Sierra Z71, 4 wheel, extend cab, 5.7L, 302000 miles. Yes that is the mileage. I'm extremely mechanically inclined and enjoy doing my on ...
5 answers • 1996 GMC Sierra • 302,000 miles
What steps must be taken when removing the radiator out of a 2000 sable do I have to remove the gray plastic piece around the fans
1 answer • 2000 Mercury Sable
Hi i have a 1995 ford taurus 3.0 se and i need to replace the rad, it looks fairly easy, but i could use a step by step guide to do this, I'm broke and can't afford a chilton is there ...
2 answers • 1995 Ford Taurus • 160 miles


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Originally Posted by johnielvis
get the monorail--they're ALL portable. Folder limits you and costs more. it's a no brainer. i've never seen a 4x5 that can't be carried on a tripod...with the lens attached--a lightweight tiltall tripod in fact--but you'll want a heavier tripod for stability and why not--the camera's so light you can afford a heavier tripod weight wise--with a nice gear center column maybe. you want portraits, maybe alonger lens than 210...telephoto if you want to keep the extensions smaller.
+1 exactly. I've carried a Calumet around on my Tiltall since 1977. Now I'm putting that Horseman monster on it. Can't carry around a Tilltall with a Horseman 8x10 on it. It's like a Mack truck sitting on top of 3 toothpicks.


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Ellen Lesperance
Ellen Lesperance (born 1971) is an artist based in Portland, Oregon.
Lesperance was born in Minneapolis and raised in Seattle. She creates art in various media but often employs the visual language of knitting, having once worked for Vogue Knitting as a pattern knitter.[1] Citing inspiration from Bauhaus-era female weavers, the Pattern and Decoration Movement, and body-based feminist artists of the 1970s and 1980s, Lesperance's gouache paintings on paper can be followed as patterns to recreate historic knit garments.[2] She sources these historic garments from archival images and film footage of women involved in Direct Action protest, including women from: the Greenham Common Women's Peace Camp, the 1999 Seattle WTO protests, Earth First!, Occupy events, feminist-era protest events, and the feminist art canon.[3] She frequently displays her paintings with her hand-knit textiles, which she says she hopes will "beckon a new wearer."[4] Additionally, Lesperance creates memorial paintings that she terms "death shrouds" for young women activists who have died while fighting for "causes greater than themselves," these women include: Rachel Corrie, Beth "Horehound" O'Brien,[5] Susana Chávez, Pippa Bacca, and Helen Thomas.[2] In 2012, Lesperance presented a solo show at Frieze Art Fair New York in which she displayed a suite of seven paintings made in the memory of slain Italian activist and artist Pippa Bacca.[6]
Lesperance has been represented by Ambach & Rice Gallery Los Angeles, Adams and Ollman Gallery, Portland, and she is included in many public collections including: the Brooklyn Museum,[7] the Museum of Arts and Design, the Portland Art Museum, the Bill and Melinda Gates Foundation, the Kadist Art Foundation, and Artist Pension Trust.[8] In 2013, she was included in Phaidon Press' Vitamin D2: New Perspectives in Drawing and in 2014, she received a Pollock-Krasner Foundation Grant, a Robert Rauschenberg Foundation "Artist as Activist" Grant, and an Art Matters Grant.[9] Between 2000 and 2005, Lesperance was engaged in costume- and prop-making for a large-format photography project with collaborator Jeanine Oleson in which both women performed as the last women on earth.[10] This project, entitled "Off the Grid," was represented by Monya Rowe Gallery, NYC, and was received by arts writers as an alternate depiction of pre-history for women wherein Lesperance and Oleson assumed "the mythical characters of prehistoric huntresses, earth goddesses, and pioneer women.",[11][12] And like Lesperance's current activist sweater painting series, the work can be read as revisionist in its nature.[13] "If this is theater," writes Julia Bryan-Wilson in ArtUS magazine, "it is theater as revelation.",[14][15] Lesperance received her MFA in Visual Arts from Rutgers University in 1999.[16]
- ^ http://www.coolhunting.com/culture/ellen-lesperance.php
- ^ a b Rattemeyer, Christian (2013). ' 'Vitamin D2: New Perspectives in Drawing' '. Phaidon Press. ISBN 0714865281.
- ^ "Art Splash: Ellen Lesperance - It's Never Over - Ambach and Rice - Los Angeles". Contemporaryartlinks.blogspot.com. 2013-02-16. Retrieved 2013-05-02.
- ^ Virtua Design. "The Strong, Star-Bright Companions by Ellen Lesperance - Guernica / A Magazine of Art & Politics". Guernicamag.com. Retrieved 2013-05-02.
- ^ http://slog.thestranger.com/slog/archives/2010/10/26/5322576-currently-hanging-ellen-lesperance/
- ^ "In Pictures - Frieze New York | AnOther". Anothermag.com. 2012-05-08. Retrieved 2013-05-02.
- ^ Collections: Elizabeth A. Sackler Center for Feminist Art: Cardigan Worn by One Woman of the Boeing Five, Tried for Entering the Boeing Nuclear Missile Plant on September 27th, 1983, Sentenced to Fifteen Days in the King County Jail for Defending Life on Earth
- ^ http://ambachandrice.com/artists/lesperance-ellen/
- ^ http://www.artmattersfoundation.org/grantees/detail/a0mi0000005wmcq
- ^ Bessire, Mark (2006). ' 'Cryptozoology: Out of Time Place Scale' '. JRP|Ringier Press. ISBN 3905770075
- ^ Koslow, Francis (2006). ' 'Exhibition Review, Tema Celeste Magazine, Issue 113:January/February
- ^ http://www.jeanineoleson.com/press/tema_celeste_jan_2006.html
- ^ http://www.nytimes.com/2005/07/08/arts/design/08cott.html?pagewanted=5&sq&st=nyt%22&scp=2%22cordy%20ryman
- ^ Bryan-Wilson, Julia (2005). Exhibition Review, ArtUS Magazine, Issue 11:December
- ^ http://www.jeanineoleson.com/press/artus_dec_2005_feb_2006.html
- ^ http://www.ellenlesperance.com


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Hey Scaly, you are not warm blooded, you don't even have fur! Silly Canadian reptile.
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Positives: Good location for staying in Vreden. Nice and quiet too. Good value for money, especially at the singly occupancy rate. Rooms are clean and mostly well decorated Hotel has a bar and restaurant that serves decent enough food and some lovely beer and wine. Staff were very friendly and as helpful as they could be with the language obstacle.... More
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Tristram Hunt is in my top 1% of Blairite backwash who think the answer to Tory elitism is Labour elitism.
BBC Parliament Cribs? "@georgegalloway: Filming outside one of Blair's seven houses. Who says crime doesn't pay? pic.twitter.com/FuUlURZnTq"
Comparing BBC coverage of the allegations against Prince Andrew to other coverage is fun. 'It's all lies, says someone also implicated'.
Okay, I think I'm about drunk enough to vote now.
I need #meninism because male models create unrealistic expectations of how men's bodies should look. pic.twitter.com/iEMhswukDA
@thephilellis Really enjoyed this, despite desperately needing to pee. Didn't mean to be a dick. pic.twitter.com/MfaulJ9n9h
#WhyImVotingUKIP Deep socio-political incohesion and the bourgeois hijacking of the Left compounded by not being loved enough as a child.
Asked someone on a date. Totally coincidental that it's Valentine's Day, but if it works out it'll be a money saver this time next year.
Great ad targeting for modern-day slavery on The Guardian. pic.twitter.com/jtbF8CV7mO
@janehill64 How can the light that burned so brightly suddenly burn so pale?
I prefer to think people using e-cigarettes are playing whimsical tunes on little futuristic pipes rather that sating chemical dependency.
If an extraterrestrial asked me to take it to my leader, we'd discuss the flaws of representative democracy before locating Jarvis Cocker.
@riobauer @seandcmorley He's infectious, yes.
Sometimes I tweet about politics and gain followers. Then I tweet about snowman sex and they go. This is why the left has failed.
FIVE parliamentary paedophile rings in the 70s/80s being investigated? Did they operate them like select committees or what? FIVE?
Cameron: "But overall, we should be clear, torture is wrong." He's got this shit sussed, I think we're fine to scrap the Human Rights Act.
Whatever happened to good old fashioned British family entertainment? pic.twitter.com/1RLPi2KY3g
Find the book nearest you right now. Turn to page 56. Read the fifth sentence. Write it in blood on a street-facing window. Sit and wait.
New drinking game: saturate the population with warped and unattainable aspirations and watch them drink themselves to depression and death.
Person in Sheffield who does stand up and runs @square_hole comedy.
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Are you Akira Hasegawa?Claim your profile
Publications (34)74.09 Total impact
Article: Filtration Leukocytapheresis Therapy Ameliorates Lipopolysaccharide-Induced Systemic Inflammation in a Rat Model[Show abstract] [Hide abstract]
ABSTRACT: Systemic inflammation, which is associated with various conditions such as sepsis, pneumonia, and trauma, can lead to multiple organ dysfunction syndrome. Systemic inflammation can be life-threatening and is often associated with conditions seen in the intensive care unit. Leukocytes exert a proinflammatory effect and damage various tissues during systemic inflammation. The purpose of this study was to determine whether leukocytapheresis therapy can prevent lipopolysaccharide (LPS)-induced systemic inflammation in a rat model. Male Wistar rats weighing 250 to 300 g were used for all experiments. Rats received an LPS injection, followed 6 h later by filtration leukocytapheresis or mock treatment for 30 min under sevoflurane anesthesia. Systemic inflammation was induced in rats by intravenous LPS injection (7.5 mg/kg) followed by filtration leukocytapheresis. Following blood filtration, we evaluated lung and liver histology, serum cytokine levels, and survival rate of rats for each treatment group. Histologic examination revealed markedly reduced inflammatory injury in lung and liver tissue harvested from rats 24 h after leukocytapheresis therapy compared with mock treatment. LPS-induced tumor necrosis factor (TNF)-α and interleukin (IL)-6 secretion was also inhibited by leukocytapheresis therapy. Moreover, survival was significantly increased in rats treated with high-efficiency leukocytapheresis compared to mock-treated rats (P<0.05). Taken as a whole, our findings indicate that filtration leukocytapheresis therapy protects against LPS-induced systemic inflammation. Therefore, leukocytapheresis shows potential as a new therapy for various systemic inflammatory diseases.Journal of Surgical Research 12/2011; 171(2):777-82. DOI:10.1016/j.jss.2010.06.021 · 1.94 Impact Factor
Article: Continuous Hemodiafiltration Therapy Ameliorates LPS-Induced Systemic Inflammation in a Rat Model[Show abstract] [Hide abstract]
ABSTRACT: Systemic inflammation can result in multiple organ dysfunction syndrome, a potentially life-threatening condition. Some reports suggest that continuous hemodiafiltration can effectively remove proinflammatory cytokines from circulation during systemic inflammation. In the present study, we investigated whether continuous hemodiafiltration therapy could prevent LPS-induced systemic inflammation and improve survival in a rat model. Male Wistar rats were injected with lipopolysaccharide (LPS; 7.5 mg/kg body weight), and 6 h later were treated with either single-pass hemofiltration (C group), continuous hemofiltration (CHF group), continuous hemodiafiltration (CHDF group), or mock filtration (Control group). We performed histologic examinations of lung and liver tissues, determined serum cytokine levels, and survival rates for each treatment group, and compared cytokine removal between CHF and CHDF therapies. Histologic examination revealed significant reduction in inflammation in lung and liver tissues harvested 24 h after CHDF compared with the Control group. Likewise, LPS-induced serum TNF-α and IL-6 levels decreased with continuous hemodiafiltration along with a significant improvement in survival. After 30 min of treatment, both CHF and CHDF removed significant amounts of TNF-α and IL-6 from the blood. However, serum cytokine levels measured before and after filtration were not significantly different. Continuous hemodiafiltration therapy lowered inflammatory cytokines and increased survival rates in a rat model of systemic inflammation. Therefore, continuous hemodiafiltration may be a potential therapy for use against various systemic inflammatory diseases.Journal of Surgical Research 12/2011; 171(2):791-6. DOI:10.1016/j.jss.2010.07.029 · 1.94 Impact Factor
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ABSTRACT: Postoperative stress produces an inflammatory response. Recent studies have shown that narcotic analgesics suppress the immune system. Nutritional management during perioperative care has also been reported to affect inflammation. We therefore examined whether remifentanil or glucose administration could ameliorate postsurgical inflammatory responses using a rat model of surgical stress. We divided male Wistar rats randomly into five groups: (1) control, (2) sevoflurane+lactated Ringer's solution, (3) sevoflurane+lactated Ringer's solution with 1% glucose, (4) sevoflurane+remifentanil+lactated Ringer's solution, and (5) sevoflurane+remifentanil+ lactated Ringer's solution with 1% glucose. In all groups, serum samples were obtained at various time points after surgery, and secreted cytokine concentrations were determined. In addition, we assessed the activation of protein kinase B (Akt) and forkhead/winged helix box class O (FOXO3), which play a role in gluconeogenesis/stress responses. Surgical stress increased the serum concentrations of tumor necrosis factor-α and interleukin-6. Groups receiving remifentanil with anesthesia showed an attenuated inflammatory response. The inflammatory response was also reduced by administering 1% glucose. Furthermore, 1% glucose induced Akt and FOXO3 phosphorylation in the quadriceps femoris muscle 12 h after surgery. Anesthesia based on remifentanil and perioperative administration of lactated Ringer's solution containing 1% glucose may be able to control inflammatory responses caused by surgical stress.Surgery Today 12/2011; 41(12):1617-21. DOI:10.1007/s00595-010-4457-z · 1.53 Impact Factor
Article: Insulin Treatment of Diabetic Rats Reduces Cardiac Function in a Lipopolysaccharide-Induced Systemic Inflammation Model[Show abstract] [Hide abstract]
ABSTRACT: Diabetes is a common comorbidity in patients with various medical conditions. Tight glucose control is known to improve systemic inflammation; however, whether it is effective in diabetic patients is unknown. The purpose of this study was to examine how strict glucose control affects systemic inflammation in diabetic patients. Male Wistar rats. We determined the effect of insulin therapy on cardiac function in a rat model of systemic inflammation. We administered lipopolysaccharide intravenously, with or without insulin, to streptozotocin-induced diabetic rats. After induction of systemic inflammation, we determined serum cytokine (IL-6 and TNFα) and nitrate/nitrite levels and measured cardiac function. Cytokine levels and cardiac function were significantly reduced in diabetic rats compared to non-diabetic rats. Moreover, insulin treatment was associated with higher cytokine levels and decreased cardiac function. In systemic inflammatory conditions, diabetes increases various proinflammatory mediators and inhibits cardiac function; insulin treatment exacerbates these effects. Thus, strict glucose control may not be desirable in diabetic patients with systemic inflammatory conditions.Journal of Surgical Research 11/2011; 171(1):251-8. DOI:10.1016/j.jss.2010.03.032 · 1.94 Impact Factor
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ABSTRACT: Acute renal damage has numerous causes, including renal ischemia-reperfusion injury. Due to its diverse actions, cepharanthine is used to treat many acute and chronic diseases, including pit viper bites, alopecia areata, and leucopenia in radiation therapy. In this study, we examined whether cepharanthine provides a renal-protective effect in a renal ischemia-reperfusion model. Male Wistar rats were divided into four groups that received the following treatments: induction of renal ischemia-reperfusion (I/R group); subcutaneous injection of cepharanthine (10 mg/kg) followed 1 h later by induction of renal ischemia-reperfusion (Cepha + I/R group); subcutaneous injection of cepharanthine (10 mg/kg) (Cepha group); and subcutaneous injection of saline followed 1 h later by sham treatment (control group). Rats were sacrificed 24 h after renal ischemia-reperfusion or sham treatment. Serum blood urea nitrogen (BUN) and creatinine (Cre) concentrations were determined, histologic examination was performed, and oxidative stress was evaluated in kidney tissue. In addition, antimycin A (AMA)-stimulated RAW264.7 cells were treated with cepharanthine to determine its antioxidant effects. Serum BUN and Cre levels were increased in the I/R group; however, these increases were significantly inhibited in the Cepha + I/R group. Similarly, kidney tissue damage observed in the I/R group was attenuated in the Cepha + I/R group. In vitro, cells treated with both cepharanthine and AMA showed reduced reactive oxygen species activity compared with cells treated with AMA alone. Our findings suggest that cepharanthine may be effective in the treatment of various types of ischemia-reperfusion injuries.Journal of Surgical Research 11/2011; 171(1):212-7. DOI:10.1016/j.jss.2010.01.025 · 1.94 Impact Factor
Article: Anti-inflammatory effects of perioperative intensive insulin therapy during cardiac surgery with cardiopulmonary bypass[Show abstract] [Hide abstract]
ABSTRACT: Recent studies have reported that controlling blood glucose with insulin can suppress systemic inflammation. In the present study, we evaluated how perioperative intensive insulin therapy (IIT) influences the inflammatory response in an artificial pancreas during cardiac surgery with cardiopulmonary bypass. We randomly divided the patients undergoing cardiac surgery with cardiopulmonary bypass into two groups: an IIT group (n = 13) and a conventional treatment (CT) group (n = 12). For the IIT group, blood glucose control was initiated with an artificial pancreas at initiation of surgery. Blood glucose was maintained at 100 mg/dl until 24 h postoperatively. Blood samples were collected to determine changes in serum cytokine levels over time. Patients' characteristics did not differ significantly between groups. Blood glucose levels were significantly higher in the CT group after surgery. Serum levels of tumor necrosis factor-α, interleukin-6, and high-mobility group box 1 were higher in the CT group than in the IIT group. Use of IIT in the artificial pancreas during the perioperative period significantly decreased the inflammatory response. Moreover, we did not find evidence of hypoglycemia in those treated with IIT. This suggests that use of IIT in an artificial pancreas can be safe and effective for critically ill patients.Surgery Today 10/2011; 41(10):1385-90. DOI:10.1007/s00595-010-4458-y · 1.53 Impact Factor
Article: Relationship Between HMGB1 and Tissue Protective Effects of HSP72 in a LPS-Induced Systemic Inflammation Model[Show abstract] [Hide abstract]
ABSTRACT: Heat shock protein 72 (HSP72(a)) exhibits cell- and organ-protective effects in response to inflammation. Moreover, high mobility group box 1 (HMGB1) protein is a lethal mediator of acute inflammation. We examined associations between HMGB1 expression and protective effects observed when whole-body hyperthermia (WH) induces HSP72 in a lipopolysaccharide (LPS(b))-induced inflammation model. Serum cytokine and HMGB1 levels, as well as HSP72 and HMGB1 expression in lung tissue were analyzed after WH treatment. Furthermore, effects of prior induction of HSP72 and silencing of HSP72 on HMGB1 secretion were examined in cultured RAW264.7 cells. Survival improved significantly from 33% in the LPS group to 78% in the WH+LPS group. Interleukin-6, tumor necrosis factor-α, and HMGB1 concentrations were significantly lower in WH-treated rats. Furthermore, inflammation was reduced in lungs of WH-treated rats. Prior induction of HSP72 resulted in significantly decreased HMGB1 secretion by RAW264.7 cells in vitro, while silencing of HSP72 prevented this decrease. Our results suggest that HSP72 induction by thermal pretreatment reduced inflammation and improved survival in the LPS-induced systemic inflammation model. These effects, which were associated with inhibition of HMGB1 expression, potentially involve HSP-mediated inhibition of HMGB1 secretion.Journal of Surgical Research 07/2011; 169(1):85-91. DOI:10.1016/j.jss.2009.10.015 · 1.94 Impact Factor
Article: Adenosine Diphosphate Receptor Antagonist Clopidogrel Sulfate Attenuates LPS-Induced Systemic Inflammation in a Rat Model[Show abstract] [Hide abstract]
ABSTRACT: Septic shock is characterized by systemic inflammation and can lead to hemorrhage and necrosis in multiple organs. Septic shock is one of the leading causes of death. Studies have reported that septic shock is strongly associated with coagulation abnormality. The adenosine diphosphate (ADP) receptor antagonist, clopidogrel sulfate (CS), inhibits platelet function. Thus, we hypothesized that CS could inhibit LPS-induced systemic inflammation in a rat model. Male Wistar rats weighing 250 to 300 g received an LPS injection, followed 6 h later by filtration leukocytapheresis or mock treatment for 30 min under sevoflurane anesthesia. Five days before LPS injection, rats were given an oral dose of water or CS (10 mg/kg body weight). Levels of proinflammatory markers were determined in serum and tissue samples, and high-mobility group box 1 (HMGB1) expression was evaluated in lung and liver tissues. Compared with LPS-treated rats, induction of cytokines (IL-6 and TNF-α) was reduced in rats pretreated with CS. In addition, histological changes observed in lung and liver tissue samples of LPS-treated rats were attenuated in CS-pretreated rats. Clopidogrel sulfate pretreatment also reduced LPS-induced HMGB1 expression in lung and liver tissues. Collectively, our findings demonstrate that CS pretreatment may have value as a new therapeutic tool against systemic inflammation.Shock (Augusta, Ga.) 03/2011; 35(3):289-92. DOI:10.1097/SHK.0b013e3181f48987 · 3.05 Impact Factor
Article: Infusion of a Glucose Solution Reduces Autophagy in the Liver after LPS-induced Systemic Inflammation[Show abstract] [Hide abstract]
ABSTRACT: Autophagy is a natural process by which a cell maintains homeostasis, usually taking place unnoticed by adjacent cells. Glucose is involved in a negative feedback loop in autophagy. Autophagy is characterized by the induction and secretion of HMGB1, yet the nature of the inflammatory response during and the effect of glucose administration on autophagy are not well understood. Systemic inflammation was induced in experimental animals by LPS injection (7.5 mg/kg) followed by a continuous infusion of either 1%, 5%, or 25% glucose. Autophagy was visualized by immunohistochemistry 12 h after LPS injection. Likewise, protein levels of microtubule-associated protein light chain 3 (LC3)-II, autophagy-related protein 7 (Atg7), and high-mobility group box 1 (HMGB1) were assayed by western blot analysis. We found that autophagy increased in liver tissue in response to LPS-induced systemic inflammation. However, protein levels decreased in rats receiving LPS and a 5% glucose solution. Our results suggest that LPS-induced systemic inflammation increases autophagy in liver cells, potentially involving the upregulation of LC3-II, Atg7, and HMGB1. We also show that a 5% glucose infusion reduces autophagy. We propose that maintaining serum glucose levels with an adequate glucose dose improves systemic inflammation by reducing autophagy.Inflammation 03/2011; 35(1):249-58. DOI:10.1007/s10753-011-9311-y · 2.21 Impact Factor
Article: Heat Shock Protein 47 (HSP47) Antisense Oligonucleotides Reduce Cardiac Remodeling and Improve Cardiac Function in a Rat Model of Myocardial Infarction[Show abstract] [Hide abstract]
ABSTRACT: Cardiac remodeling after acute myocardial infarction is regulated by components of the extracellular matrix. The 47 kD heat shock protein 47 (HSP47) is a collagen-specific molecular chaperone that plays a major role during procollagen processing and/or secretion. The purpose of the study was to determine whether HSP47 inhibition can mitigate ligated left anterior descending (LAD) coronary artery-induced myocardial infarction in rats. Rats were randomly divided into four experimental groups and subjected to the following treatments: 1) intravenous (IV) administration of saline; 2) ligation of the LAD coronary artery; 3) ligation of the LAD coronary artery + IV administration of HSP47 antisense oligonucleotides; or 4) IV administration of HSP47 antisense oligonucleotides. We investigated cardiac histopathology, performed immunoblot and immunohistochemical analyses, and examined cardiac function. Rats with ligated LAD coronary artery experienced upregulation of HSP47 expression, remodeling of the left ventricle, and cardiac dysfunction. In contrast, rats with ligated LAD coronary artery treated with HSP47 antisense oligonucleotides had significantly reduced HSP47 expression, cardiac remodeling, and improved cardiac function. Intravenous (IV) administration of HSP47 antisense oligonucleotides alone had no effect on cardiac morphology. The data strongly support the idea that changes in the extracellular matrix and its components are important determinants of cardiac remodeling after myocardial infarction.The Thoracic and Cardiovascular Surgeon 03/2011; 59(7):386-92. DOI:10.1055/s-0030-1250658 · 0.98 Impact Factor
Article: PP236 EFFECT OF NUTRITIONAL INTERVENTION ON SEPSIS INDUCED AUTOPHAGY IN MICE CECAL LIGATION AND PUNCTURE MODELClinical Nutrition Supplements 12/2010; 5(2):115-115. DOI:10.1016/S1744-1161(10)70311-2
Article: Alternate Day Calorie Restriction Improves Systemic Inflammation in a Mouse Model of Sepsis Induced by Cecal Ligation and Puncture[Show abstract] [Hide abstract]
ABSTRACT: Calorie restriction (CR) exerts cytoprotective effects by up-regulating survival factors, such as mammalian target of rapamycin (mTOR), sirtuin, and peroxisome proliferator-activated receptor-γ co-activator 1α (PGC-1α). These survival factors have well-established roles in attenuating the inflammatory response. However, it is unclear whether CR affects sepsis-related inflammation. The purpose of this study was to determine whether CR affects sepsis-induced inflammation in a cecal ligation and puncture (CLP)-induced mouse model of sepsis. Male C57BL/6N mice underwent alternate day calorie restriction or normal feeding for 8 d before CLP-induced sepsis. After induction of sepsis, liver and lung histopathology and serum levels of cytokines and survival factors were assessed. Serum cytokine and high mobility group box protein 1 (HMGB1) levels were lower in animals that underwent alternate day calorie restriction compared with normally-fed mice after CLP. Alternate day calorie restriction also increased levels of sirtuin, PGC-1α, and mTOR. While 80% of mice in the CLP group died within 48 h after undergoing CLP, 50% of mice died in the ACR + CLP group (P < 0.05). Alternate day calorie restriction decreased mortality in a mouse model of sepsis. In addition to attenuated organ injury, a significant reduction in cytokine and HMGB1 levels was observed. These findings suggest that alternative day calorie restriction may reduce excessive inflammation.Journal of Surgical Research 12/2010; 174(1):136-41. DOI:10.1016/j.jss.2010.11.883 · 1.94 Impact Factor
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ABSTRACT: The incidence of acute kidney injury (AKI) in the elderly population has steadily increased in recent years. Functional recovery after AKI is also impaired in the elderly; however, the mechanism underlying these age-related differences is not well understood. In the present study, we assessed kidney morphology, function, and oxidative stress in young and aged rats after renal ischemia and reperfusion. Young (6- to 7-wk-old) and aged (60- to 65-wk-old) male Wistar rats were divided into four groups based on age and treatment: renal ischemia-reperfusion in young rats (young IR); renal ischemia-reperfusion in aged rats (aged IR); sham treatment in young rats (young control), and sham treatment in aged rats (aged control). Rats were sacrificed 24 h after treatment, serum blood urea nitrogen (BUN) and creatinine (Cre) concentrations were determined, and kidney tissue histology and 8-hydroxydeoxyguanosine (8-OHdG) levels were evaluated. After ischemia-reperfusion, serum BUN, and Cre levels were higher in aged rats than in young rats. Reperfusion-induced kidney damage and kidney tissue 8-OHdG levels were also more severe in the aged IR group. Moreover, plasma antioxidant potential was lower in aged IR rats than in young IR rats. Aged rats exhibited reduced antioxidant potential and increased oxidative stress after ischemia-reperfusion. Our findings demonstrate that aged rats experience more severe reperfusion-induced injuries compared with young rats.Journal of Surgical Research 09/2010; 172(1):153-8. DOI:10.1016/j.jss.2010.08.034 · 1.94 Impact Factor
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ABSTRACT: Ischemia-reperfusion (I/R) contributes to acute kidney injury (AKI). On the other hand, anti-oxidative drugs help to prevent renal injury caused by I/R. The current study examined whether a new antioxidant, ETS-GS, inhibits reactive oxygen species (ROS) generation and thereby prevents renal I/R injury in rodent models. Rats with experimentally-induced renal I/R injury were treated concurrently with an intravenous injection of either ETS-GS or saline. Anesthesia was induced with sevoflurane. Histologic examination revealed marked reduction of interstitial congestion, edema, inflammation, and hemorrhage in kidney tissue harvested 24 h after ETS-GS treatment. Renal I/R-induced secretion of nitric oxide (NO) in serum was inhibited by ETS-GS treatment. Furthermore, malondialdehyde (MDA) levels in the kidney were significantly lower in ETS-GS-treated rats with renal I/R. Moreover, when murine macrophage-like RAW264.7 cells were stimulated with antimycin A in the presence or absence of simultaneous ETS-GS treatment, ETS-GS decreased ROS levels. Thus, ETS-GS lowered ROS levels in cultured cells, reduced serum NO levels, decreased renal MDA levels, and protected rats against I/R-induced kidney injury. Given these in vitro and in vivo findings, ETS-GS is a strong candidate for future exploration of therapeutic potential in various human I/R diseases.Journal of Surgical Research 02/2010; 171(1):226-33. DOI:10.1016/j.jss.2010.01.039 · 1.94 Impact Factor
Article: Dendritic cell activation in response to ischemia-reperfusion injury of the small intestine[Show abstract] [Hide abstract]
ABSTRACT: Recent studies have increased our understanding of the important role that the immune system plays in ischemia-reperfusion (I/R) injury. Although dendritic cells (DCs) are important regulators of intestinal immunity, their role in the response to intestinal I/R injury is not well understood. The aim of this study was to determine whether I/R injury affects DC infiltration into the intestinal barrier. Wistar rats were subjected to I/R injury or a sham operation. Dendritic cells were visualized by immunohistochemistry, and after 12 h of reperfusion protein levels for nucleotide-binding oligomerization domain protein 2 (NOD2), high-mobility group box 1 (HMGB1), and Toll-like receptor 4 (TLR4) were assayed by Western blotting. The number of DCs increased at the small intestine barrier in response to intestinal I/R. A Western blot analysis of small intestinal tissue revealed that levels of NOD2, HMGB1, and TLR4 protein increased in rats subjected to I/R injury in comparison to control rats. These results suggest that intestinal I/R increases the infiltration of DCs into the small intestine, thus potentially involving the upregulation of NOD2, HMGB1, and TLR4. Therefore, intestinal I/R might activate DCs through NOD2 and HMGB1.Surgery Today 02/2010; 40(2):137-45. DOI:10.1007/s00595-009-4033-6 · 1.53 Impact Factor
Article: Cepharanthine Exerts Anti-Inflammatory Effects Via NF-κB Inhibition in a LPS-Induced Rat Model of Systemic Inflammation[Show abstract] [Hide abstract]
ABSTRACT: Systemic inflammatory response syndromes involving sepsis continue to have extremely high mortality rates. Inflammation is difficult to control when it spreads throughout the body and often progresses into multiple organ dysfunction, eventually leading to death. Cepharanthine (CE) is a plant alkaloid that possesses bioactive properties, with various known actions. In the present study, we investigated protective effects of CE in a lipopolysaccharide (LPS)-induced systemic inflammatory response model and examined underlying mechanisms. We intravenously administered LPS (7.5 mg/kg) to male Wistar rats after intraperitoneal injections of either physiologic saline (LPS group) or CE (10 mg/kg; CE + LPS group), or 2 h before intraperitoneal injection of CE (post-CE + LPS group). We then compared changes in serum cytokine and nitrogen oxide levels over time, and performed histologic examinations of the lungs and liver in each group. Using mouse macrophage RAW264.7 cells, we determined the effect of CE on LPS-induced cytokine secretion into the cell culture medium, as well as NF-κB activity. The increase in LPS-induced cytokine levels in rat serum was significantly inhibited by CE treatment; this effect was also seen in the post-CE + LPS group. In addition, we observed histologic improvements with CE co-treatment. In vitro, CE inhibited NF-κB activation by inhibiting the IKK pathway. These results suggest that CE exerts protective effects, at least in part, via NF-κB inhibition. CE may thus be a potential agent for treating systemic inflammatory response syndromes such as sepsis.Journal of Surgical Research 02/2010; 171(1):199-204. DOI:10.1016/j.jss.2010.01.007 · 1.94 Impact Factor
Article: Stimulation of autophagy in the liver by lipopolysaccharide-induced systemic inlammation in a rat model of diabetes mellitus[Show abstract] [Hide abstract]
ABSTRACT: The dysregulated metabolism associated with diabetes mellitus (DM) impairs membrane trafficking events in the liver, including the process of autophagy, which is an essential ongoing cellular process that is highly regulated by nutrients, endocrine factors, and signaling pathways. High-mobility group box 1 (HMGB1) is a nuclear protein with a known role in systemic inflammation and the related various organ injuries. However, its relationship to autophagy is not well understood. The aim of this study was to investigate the effects of inflammation injury on autophagy in the liver in a rat model of DM. DM was induced in animals with streptozotocin, followed four weeks later by induction of inflammation by LPS injection. At 12 h after LPS administration, autophagy was assessed by immunohistochemistry and Western blot analysis of microtubule-associated protein light chain 3 (LC3)-II, as well as transmission electron microscopy. Expression of HMGB1 was also examined by immunohistochemistry and Western blot analysis. Western blot analysis of liver tissue revealed that levels of LC3-II and HMGB1 protein increased in DM rats subjected to LPS-induced inflammation compared with non-DM rats. Autophagy was particularly enhanced in DM rats. Thus, autophagy might be related to progression to organ injury in patients with DM, and inflammation in these patients might be associated with over-induction of autophagy and increased HMGB1 expression.Biomedical Research 01/2010; 31(5):263-71. DOI:10.2220/biomedres.31.263 · 1.14 Impact Factor
Article: Hyperglycemia contributes to cardiac dysfunction in a lipopolysaccharide-induced systemic inflammation model[Show abstract] [Hide abstract]
ABSTRACT: Hyperglycemia is frequently observed in nondiabetic patients during acute illness. Furthermore, intensive insulin therapy significantly reduces mortality and morbidity due to several critical illnesses, including cardiac or infectious diseases. The purpose of this study was to determine whether cardiac function is affected by hyperglycemia and its treatment with insulin. Lipopolysaccharide (LPS) was administered intravenously to rats, with or without the administration of insulin with glucose. University Medical Center research laboratory. Male Wistar rats. In this study, we determined the effect of hyperglycemia and insulin therapy on cardiac function in an LPS-induced systemic inflammation model. Levels of serum cytokines, nitrate/nitrite, and high-mobility group box 1 protein after LPS treatment were measured in hyperglycemic rats and those treated with insulin. The following parameters were examined to assess cardiac function in Langendorff-perfused hearts: left ventricular developed pressure, left ventricular end-diastolic pressure, and left ventricular pressure development during isovolumetric contraction (+dP/dtmax) and relaxation (-dP/dtmin). We observed that levels of cytokines, nitrate/nitrite, and high-mobility group box 1 significantly increased. However, treatment of hyperglycemic rats with insulin was associated with significantly less severe disease as assessed by cytokine levels. Furthermore, hyperglycemia was associated with decreased +dP/dtmax and -dP/dtmin in Langendorff-perfused hearts of hyperglycemic rats, whereas insulin treatment improved these parameters. Hyperglycemia was associated with the induction of various inflammatory mediators and an inhibition of cardiac function. Treatment of hyperglycemia with insulin protected against inflammation and cardiac dysfunction in a rat model of LPS-induced systemic inflammation. This improvement is likely because of the neutralization of deleterious effects associated with hyperglycemia and the specific actions of insulin on the inflammatory response.Critical care medicine 08/2009; 37(7):2223-7. DOI:10.1097/CCM.0b013e3181a007c6 · 6.31 Impact Factor
Article: The Effect of Experimental Diabetes on High Mobility Group Box 1 Protein Expression in Endotoxin-Induced Acute Lung Injury[Show abstract] [Hide abstract]
ABSTRACT: The incidence and prevalence of diabetes have recently increased. Hyperglycemia, which is commonly seen in intensive care medicine, is associated with increased morbidity and mortality. For instance, diabetes is associated with altered immune and hemostatic responses. High mobility group box 1 (HMGB1) protein plays a key role in various inflammatory diseases. This study investigated the increase in lung damage due to diabetes and the rise in HMGB1 levels in a lipopolysaccharide (LPS)-induced systemic inflammation rat model. Diabetes was induced by streptozotocin infusion 4 wk prior to LPS administration, followed by measurements of blood glucose and serum cytokine levels. Separate cohorts were sacrificed 12h post-LPS administration and analyzed for lung damage. Diabetic animals had significantly higher blood glucose and enhanced lung damage. In addition, levels of serum HMGB1, tumor necrosis factor-α, and interleukin-6 were increased in diabetic rats. Diabetes may exacerbate systemic inflammation as evidenced by higher serum HMGB1 and cytokine levels and enhanced lung damage in the rat systemic inflammation model.Journal of Surgical Research 08/2009; 168(1):111-8. DOI:10.1016/j.jss.2009.07.039 · 1.94 Impact Factor
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ABSTRACT: Type 1 angiotensin II (AT1) receptor antagonists have anti-inflammatory effects in vitro and in patients. The purpose of this study was to investigate whether losartan (LOS), an AT1 receptor antagonist, reduces lung damage by inhibiting the induction of high mobility group box 1 (HMGB1) protein and cytokines by lipopolysaccharide (LPS; serotype: O127:B8) in a rat model. We used male Wistar rats. Control group rats received a 0.9% NaCl solution. The LOS + LPS group rats received LOS (50 mg kg(-1)) before LPS (7.5 mg kg(-1)) administration. LPS group rats received injection of LPS (7.5 mg kg(-1)). We performed immunohistochemistry, ELISA, and western blot analysis to examine the suppressive effects of LOS on LPS-induced cytokine induction. Plasma concentrations of cytokines (IL-6 and TNF-alpha) and HMGB1 (p < 0.05) were markedly reduced in the LOS + LPS group compared to the LPS group. LOS also inhibited the LPS-mediated decrease in angiotensin-converting enzyme 2 (ACE2) activity (p < 0.05). Immunohistochemical analysis revealed positive staining for ACE2 in lungs from both control and LOS + LPS groups. The intensity and degree of ACE2 labeling in lung tissue sections from the LPS group were markedly reduced compared to the control and LOS + LPS groups (p < 0.05). Additionally, RAW264.7 murine macrophages were stimulated with LPS, with or without simultaneous LOS treatment, resulting in inhibition of IkappaB phosphorylation. Treatment with LOS improved lung injury in an endotoxin shock model system by an anti-inflammatory action that inhibits reduction of ACE2.Intensive Care Medicine 07/2009; 35(8):1471-8. DOI:10.1007/s00134-009-1545-x · 7.21 Impact Factor
Top Journals
Oita University
Ōita, Ōita, Japan
- • Faculty of Medicine
- • Department of Anesthesiology


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Posted by GS on 11th Jan 2015
Oh man! These are sooooo hot. I just feel super sexy when wearing these and sometimes I wonder how it would look like of I d cut out the front lining....
Anyway, it's a head turner! I have had lots of success in these!
Be aware: they are very low in the front and in the rear! My butt crack definitely is showing!
The Signature collection is also part of our 'Super Low-Rise' swimwear. Designed for men that dare to bare. This improved design sits low with more room on the front than the V01 cut.
1. The 2EROS signature print is matched with the external drawstring
2. Roomier front pouch
3. Front lining
Materials: 80% Nylon, 20% Lycra
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Campus Pride, a nonprofit that works for safer college environments for LGBT students, has compiled its first top ten list of trans-friendly colleges and universities.
Sure, we know the partiers turn to University of Florida or Ohio State and the brainiacs look to Harvard, and Columbia. But for the trans community, selecting a college can be fraught fraught with additional perils that even their gay and lesbian classmates can unintentionally exacerbate—from housing issues to isolation and rejection.
Campus Pride's executive director Shane Windmeyer and trans author Genny Beemyn based their ranking on which schools had policies that were most trans-affirmative, including things like non-discrimination polices that include specific protections for gender identity and/or expression, offering gender-inclusive bathrooms and lockers, forms that allow for the recognition of trans identities and, arguably most importantly, vibrant, dynamic LGBT organizations staffed and lead by members of the trans community.
Here's how the top ten broke down:
1. Ithaca College
2. New York University
3. Princeton University
4. University of California, Los Angeles
5. University of California, Riverside
6. University of Massachusetts, Amherst
7. University of Michigan, Ann Arbor
8. University of Oregon
9. University of Pennsylvania
10. University of Vermont
Not surprisingly, the list skews towards colleges on the East and West Coasts, where cultures of inclusiveness tend to take root first. But given how quickly progress is being made, we wouldn't be at all surprised to see schools from the Midwest and South cropping up in the years to come. Just think, soon trans student will be just as home with a beer bong and embarrassing tattoos as anyone else.
Is your alma mater on the list? Share you school pride in the comments!
I'm not sure who you asked, but you completely missed The University of Arizona, in Tucson, which:
– was the first state university in the nation to issue a trans-friendly campus restroom policy (more than half a decade ago)
– makes it easy to update student records and ID cards
– offers housing options for trans and gender-neutral students
– is mindful of trans inclusion in all of its diversity policy work
– is inclusive of trans and LGB people on a variety of committees, boards, and councils
– as of this fall now covers trans-related medical needs in the student health insurance!
As an added bonus, noted Emmy-winning transwoman Susan Stryker, PhD, is the Director of the Center for LGBT Studies, so there's at least one out trans person in a visible position of campus leadership…
It doesn't get much more trans-friendly than that, if you ask me. :)
The way you reported on this is kind of inaccurate. That is not a ranking of trans* friendly colleges- instead they are listed alphabetically and should be considered as a group. If they were listed in order of inclusiveness/quality, Penn and NYU would be numbers 1 and 2 because they have the most extensive policies and the largest number of self identifying students utilizing them. Also- plenty of brainiacs choose Penn!! Especially LGBTQ brainiacs- but i'm a little biased ;)
Nice little dig at Ohio State. As a bi and trans person who just graduated from there, I have to stand up for it a little by saying that it's actually a great place to be queer.
It scores a 5 out of 5 on the Campus Pride index, and it deserves that score, due to things such as a very active set of LGBT student groups, health insurance that includes trans-related doctors visits and medication (sadly though, not surgery), LGBT inclusive non-discrimination policies, and the entire city of Columbus has LGBT inclusive non-discrimination laws as well, including in public accommodations (which includes the basic but often not granted right to go to the restroom that matches one's gender identity).


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Vienna City Hop-on Hop-off Tour
We've selected the best candid trip photos submitted by our users to help you decide if the Vienna City Hop-on Hop-off Tour is right for you. Make the most of your next trip to Vienna with Viator's exclusive Photo Galleries.
Click here for tour details, schedule and pricing
hop on hop off bus
September 2009
hop on hop off bus
Two of us
September 2009
At the Schonbrun palace


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BP, Reliance plan $5bn investmentComment on this story
New Delhi - Britain's BP and India's Reliance Industries said Tuesday they plan to invest more than $5 billion to develop India's largest gasfield in the Bay of Bengal in the next few years.
"This plan, when implemented, would entail a potential total investment in excess of $5 billion over the next three to five years," the two companies said in a statement, referring to the KG-D6 gasfield. - Sapa-AFP
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'I'm mad as hell, and I'm not going to take it anymore!'
- Filed Under
In 1976, a movie called "Network" gave birth to a now-famous line in the annals of free thought. With the eyes of millions of viewers on him, Howard Beale lays the brutal truth on everyone about the faults of the economy and the devalued dollar, rising crime rates and remarked that things aren't just bad but worse than bad - in fact, they're crazy. He finishes with the famous line, "I'm mad as hell, and I'm not going to take it anymore!" and he asks everyone at home to stick their heads out of their windows and yell just that to the skies and streets below.
In the movie, everyone obliges. But what would it take for something like that to happen in the real world?
It's not as if we don't have the cause. We know that our government is spying on us, and has with great detail since the Patriot Act and likely even before the Bush administration. We know through Wikileaks of the atrocities committed our military and we know that those deemed "traitors" like Edward Snowden and Pvt. Chelsea Manning, formerly Bradley Manning, are not applauded for exposing a much-needed truth, but condemned for their efforts.
We know the same defense contractors that help supply the weapons of war contribute money to the politicians who put our soldiers to war in the first place. We know our prison system is a commodity that is traded on Wall Street, and as the number of inmates rises, so does the value of the prison. We know banks can get away with essentially robbing the American people in full view, be it through government bailouts or shady subsidized housing loans.
We know there are genetically modified organisms in our foods and corporate giants like Monsanto, banned in dozens of other countries around the world, are left to run their machine without interference in the United States, potentially poisoning our food supply.
We know education has been slipping for decades, and that we have fallen well behind in areas of math and science. We are a nation that does not offer free health care or free education through college, as many other countries do - as I feel it's a human right to be healthy and to learn without restriction. Our poverty levels are higher than ever; the gap between the rich and the poor is higher than ever. And yet when we turn to the media for news and information, we get, "Who wore it better, Miley Cyrus or Rihanna?"
It is a sad state of affairs. What will it take for us to finally say "enough is enough?" What else will it take? Radio frequency identification chips in our drivers licenses? More inflation along with a minimum wage that has been dormant for years? An overabundance of "food-like products" filling our mouths as opposed to real food, potentially contributing to rising cancer rates while pharmaceutical companies continue to rob us blind?
The roots of greed and power have taken this nation in a scary direction. Yet we ignore it. We hide in our habitual comforts. I am guilty, too.
Will there one day be a second revolution started in great numbers by the people? It was Thomas Jefferson who said, "Every government degenerates when trusted to the rulers of the people alone. The people themselves, therefore, are its only safe depositories."


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Photo: Ralph Anderson,
Anna Sova Food Paint
Made with the same ingredients as foods like yogurt and chocolate, this Dallas, Texas-made interior wall paint "smells like a milk shake," just like the can claims. The low-VOC formula is available in more than 500 colors. annasova.com; $12 (1⁄2 pint) or $69 (1 gallon)