text:
In 2011, six Tata Group companies (among 20 Indian companies) were listed on the Boston Consulting Group (BCG)'s list of the top 100 'Global Challengers' from emerging markets. And it's noteworthy that BCG's methodology screens out companies "that could only pursue low-end, export-driven models". The Tata Group includes a substantial proportion of India's globally competitive, outward looking enterprises. Looking at the group on a per-employee basis, the international focus of the group is also exemplified by the fact that roughly half of the group's total employment is in TCS, a company that derives over 90 per cent of its revenues from the Indian market.
The Tata Group's international expansion strategy is also notable for the variety of modes employed. Organic growth in overseas markets (most notably by TCS) proceeded alongside India's boldest programme of overseas acquisitions (big deals from Tetley on through Corus and Jaguar Land Rover, as well as many more small deals). As an acquirer, the Tata Group cultivated a distinctive buy-and-learn approach, a stark contrast, for example, to GE's buy-and-restructure pattern. And don't forget inward deals, of which Tata Starbucks is just the latest example—deals that trade on trust in the Tata name.
With respect to acquisitions focused on brands, Tata Motors is perhaps unique among large Indian firms in having become an owner of a significant luxury brand through its acquisition of Jaguar Land Rover. The success of this acquisition also stands in positive contrast against the generally poor record of companies from other emerging markets buying foreign brands—like the TCL-Thomson tie-up and BenQ's acquisition of the Siemens mobile phone business. And, as far as acquisitions of critical industrial enterprises go, note how the Tyco deal got the Tata Group into the business of facilitating international information flows, a critical enabler of India's globalisation.
A final thought relates to Indian national identity and pride in the Tata Group's globalisation. Going back to its earliest days, one of the main strands in the Tata Group's history was proving that Indians could do what before only foreigners (British) had done in India. The Tata Group always regarded its role as pushing forward India's development. Making a run at proving that an Indian group is best positioned to nurture manufacturing in the United Kingdom just might be Ratan Tata's sweetest homage to the ideals of the group's founder, Jamsetji Tata.
Pankaj Ghemawat is the Anselmo Rubiralta Professor of Global Strategy at IESE Business School, University of Navarra, Spain.; E-mail your columnist: PGhemawat ATiese.edu
Thank you to all those who have taken the trouble to read the article and share their thoughts. Out of the arguments made here, there are two that perhaps need answering. So here they go.
1. The first part of the article compares outcomes (relative percentages of population of the religions concerned) irrespective of the process that led to those outcomes - whether immigration, relatively faster population growth or conversions. This was for two reasons. One, to put the figure of 2.3 per cent in "numerical perspective", as the article itself explained. The second reason was that outcomes are ultimately what the crux of debate is about. The rest of the article in any case dealt with process - or conversions in this case, from both a contemporary and historical perspective.
2. Some commenters have tried to cast doubts on the reliability of Census 2001. Those who do this should bear in mind that Census 2001 was conducted by a BJP government. Considering the extreme importance that BJP gives to this issue, it would be reasonable to expect that IF it had perceived a problem with the methodology that was distorting the numbers, it would have fixed it. As the article mentioned, BJP or BJP-supported governments have been in power for 10 of the last 40 years, or about a quarter of the time, and the only reasonable conclusion one can arrive at is that any misreporting of numbers, real or perceived, would be marginal and hence, not of importance.
To all other arguments made, my answer is the following: Please read the article again, with particular focus on the quotations of Vivekananda and Monier Williams, and the history of the missionary efforts in Bengal and their outcome.
A much needed image makeup for the Tatas from the Rahejas pwned media group.
A fuller picture of the hero would have included his exit from Bengal after his land grab failed. And the controversial land gift by Modi to attract bigger money.
In all, Nira Radia would have given the complete picture, with all the shady deals that Indian business is incomplete without, and the paid media make ups.
Range Rover should be run by Britishers, in Great Britain. I think, it's great that Tata & Sons can help the company, and continue to do so. There seems to be everything right with Range Rover. And Jaguar. Jaguar is very important, because more people buy Jaguar cars, and people who buy Land Rover and the Range Rover, are fewer. I personally love the TATA Safari, I appreciate it has a 140 PS(?) engine, when previously, I appreciated it had a 90 PS(?) engine.
Unreservedly admiring of Ratan and the TATA group.
Unreservedly proud of their success in showing the world what Indians can do
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Altra Stock Gaps Down On Today's Open (AIMC)
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text: If you look at the calendar for the coming week you'll see this word written in on Thursday: "Epiphany." That seems strange. Epiphanies don't seem like the sort of thing one can schedule ahead of time and plan for like that. "Good meeting, Jim, let's meet again tomorrow to finish up." "Fine, just let me [Read More...]


text:
DO you guys think vino and cadel have some chances now that the mountain stages are starting i believe tomorrow?
DO you guys think vino and cadel have some chances now that the mountain stages are starting i believe tomorrow?
Anything's possible, eh?
Of course Vino has chance. Anyone who wears a jersey like this always has chance.
Sheriff: You have a lot of experience with bounty hunters, do you?
Mattie Ross: That is a silly question. I am here to settle my fathers affairs.
Sheriff: All alone?
Mattie Ross: I am the person for it. Mama was never any good at sums and she could hardly spell CAT.
--from the movie True Grit (2010)
Oh yeah! Vino is known for making some breakaways. He can be real good but he can also lose time so it's aleast 50/50. Plus Sasstre (spelling?) really sucked on one of the previous stages with a short gentle climb. Shocked that he lost time on that stage!
Cadel's best bet would bet to punch his main competitors in the nose! That dude is crazy!
Vino will not win. Can't climb the steep ones. He will keep it interesting though.
in my book, vino and tondo are the favorites to win the overall as of today.
Sastre (tailor in english) as a racer is not that good and i bet he will lose time tomorrow, cadel and vino teams need to to prepare something together or both will go down big time. It is amazing how cadel is still running practically by himself no matter in which team he is, and at this point wonder if it has something to do with his temper. Vino can't do much also wit h the team he has... Vino was in my book as a winner also...
Everyone has a right to an opinion. However, this does not mean that one's opinion is right.
Don't have much hope for Vino or Cadel to win now. But both of them have showed some major form this spring between their classics wins and this Giro. Both should be a lot more formidable later this year when they have their full team supporting them later this year. Though obviously that's less likely for Vino because of Contador. But Cadel should benefit by having guys like Hincapie with him.
I doubt contador (accountant in english) will do something this year, last race he basically dropped because of allergies? Nobody knew he had allergies before... I believe the kid was at 100% and is going down big time, and now is time for vino to pull up something because he is going up. Coming back to the giro, vino and cadel together need to basically do the "cancellara" in at least 2 stages and drop everybody from their wheels. Liquigas wont let them go and the only way is to do a "Cancellara". Sastre doesnt have legs and the italians arent that good as years before.
1st day watching the giro on line and darn vino and cadel are not attaching at all, the good thing is that they will get like 1 minute off the leader.
I think at the end of the stage Evans, Vino, Basso will get to the finish together.
eta: or maybe not, 30 seconds is quite a bit to catch up, I thought he was closer.
Cadel fought a lot today, vino also. Lets see what happens because all of the guys now can climb and can TT big time. Even will win the TT or Vino, taking bets.
He's been affected by allergies in spring races in years past. He was struggling with them two years ago when he won the Giro.
Here's from a VeloNews interview with Antonio Colom last year:
and the link
VN: Do you continue with the treatments?
TC: I still take the vaccinations and I will be for the rest of my life. Throughout the entire year
I have to take pills, a vaccination once a month, and, if I have a crisis, I have a spray. It's not
to be able to breath better; it's simply to be able to breath. When I look back, I wonder, how
did I race before? I would just die. The sport directors always thought I was crazy because
every time it rains or it's cold, I'd happy. Why? Because, for the first part, half of the riders in
the peloton don't like rain. But for me, it was because I could breath like a normal person and
– boom! – I could go. Last year at the Giro, Contador is like me, very allergic, and every night
we were at the TV, watching the weather with rain, we were like, yes! Rain!
Last edited by USAZorro; 05-23-10 at 09:10 PM.
In search of what to search for.
One of the best stages ever... TOC final stage was not bad, the only problem is that Radio schack planned the trick too late, i noticed they wanted to do the same thing they did with LA years ago... popo waiting for Levi... then nothing happened. Between levi and zabriskie could have kill rogers, the problem is that none of them didnt want to lose the race, makes sense anyways. Even if they could have attached before horner could have had some better chance... Well is better say it that do it anyways... great race also but it needed more attaches in my opinion.
True, wrong word choice... english makes non sense sometimes
Today was a good stage. Well as exciting as can get for a race! Lots of suffering and some suspense!
Awesome stage today. I don't want to answer this thread based on today. Watch and your answer will be obvious. I will say that given the 15K' of climbing, the GC contenders left it all on the road.


text:
Herb Dean gives his side of Roy Nelson / Kimbo Slice fight
Recent Comments »
10/5/09 1:40 AM by bakalol
Dawg..... you just don't get it homie.
10/5/09 1:37 AM by ksooner76
Herb is one of the best refs in mma......
10/4/09 3:15 PM by Dogman
^^^nicknames that is.
10/4/09 3:14 PM by Dogman
ppl do get silly with it at times.
10/4/09 3:04 PM by JkdSam
I never said I don't understand what they mean when they say p4p. I said it's fucking stupid to say it.
10/4/09 1:08 PM by Dogman
Ok JksdSam let me explain it to you by comparison. Mark "The Antidote" Coleman. Mark is not really an Antidote. Antidote def:"An antidote is a substance which can counteract a form of poisoning.[1] The term ultimately derives from the Greek ??????????? antididonai, "given against". Mark isn't really an antidote, but ppl think he will take care of LM. So in a similar fashion ppl refer to Herb Dean as the best p4p in the same way. Is their weight classes in reffing ? NO but its ppls way of saying he is the best using a fighting term "p4p". How in the hell can you not get it?
10/4/09 8:18 AM by JkdSam
If not understanding what weight has to do with the quality of a ref means I rode the short bus, then I guess I did. But, considering you're the only one who found fault with what I said, i'm gonna assume that i'm correct and you're a total fag idiot.
10/3/09 8:18 PM by mrgoodarmbar
I would have argued against any standup, but canuck makes a pretty good point....as long as long as Herb gives plenty of warning about the impending standup.
10/3/09 8:01 PM by canuck34
"Explain how a stand up would have been warranted."If you are on the ground, even in a good position, and you are not effectively working to end the fight it generally gets stood up. I agree, the xifix is a really good spot, but guys have been stood up from side control before, half guard etc...because they were just lying there doing little. Roy basically had kimbo pinned but was doing little damage and seemed to not be interested in finishing the fight.I'm glad Herb didn't stand them up, but I get what he is saying. Basically it would be like Roy getting mount on Kimbo and instead of hurting him doing the spit...suck it back up trick.Roy should have worked from the crucifix to try to get a sub or really tried to smash Kimbo's face.
10/3/09 7:33 PM by SpiderManBJJ
Herb Dean is the best ref ever.He reffed for years in KOTC then UFC and cant think of one bad stoppage.


text: I shoot mostly 35mm film, and Ilford Delta films. I have however bought a few FP4s, and need some advice on how to develop them for later printing in size 20x30cm or 30x45cm. I have Rodinal and Tetanal Ultrafin Pluss. What results can I expect? What is the best way to develop this film?


text:
Ulcerative Colitis WisdomCard™
Abbott's Humira OKed for new ulcerative colitis indication in EU « pharmaphorum forums
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text:
A new film is gearing up that promises to show you an entirely different side of the world's most notorious and controversial paranormal phenomenon – The Amityville Horror. Read on for all the details concerning why it just may be time for you to stock up on Bibles (hey, it couldn't hurt) and nightlights.
From the Press Release
Dimension Films and Miramax today announced the production of THE AMITYVILLE HORROR: THE LOST TAPES. This is the first film to be produced under the agreement between Miramax and The Weinstein Company to create sequels to some of Miramax's best-known properties.
Dimension also announced that it has acquired the rights to a new screenplay for the film by Casey La Scala and Daniel Farrands. Farrands and La Scala are also set to direct the film. Production will commence this summer with a release date scheduled for January 27, 2012. The announcement was made today by Bob Weinstein, co-chairman of The Weinstein Company (TWC), and Mike Lang, CEO of Miramax.
THE AMITYVILLE HORROR: THE LOST TAPES showcases the events after the time of the original The Amityville Horror book and movie through found footage dating back to 1976. An ambitious female television news intern, on the verge of breaking the most famous haunted house case in the world, leads a team of journalists, clergymen and paranormal researchers into an investigation of the bizarre events that will come to be known as The Amityville Horror … only to unwittingly open a door to the unreal that she may never be able to close.
"We are thrilled to return to the mythology of The Amityville Horror with a new and terrifying vision that will satisfy our existing fans and also introduce an entirely new audience to this popular haunting phenomenon," said Bob Weinstein.
THE AMITYVILLE HORROR: THE LOST TAPES is being produced by Jason Blum, Casey La Scala and Daniel Farrands. Bob and Harvey Weinstein are Executive Producers. Blum has previous experience with found footage films having produced PARANORMAL ACTIVITY 1 and 2, which have grossed close to $400 million worldwide.
The Amityville Horror stories are based on events in the life of George Lutz. The Amityville Horror project is one of several sequel or development projects that Miramax and TWC are currently collaborating on.
"I'm thrilled to be working with Bob to reinvent one of the all-time great horror franchises, and I think this new installment will really hit home with a new generation of moviegoers," said Jason Blum.
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Get those Kebabs cooking with the Chef'n Branch BBQ Skewer. This innovative Chef'n Skewer utilizes a multiple branch design that can hold twice as much food as a traditional skewer. This metal skewer is made of stainless steel with a wooden handle. The heat resistant silicone hanging loop makes storing easy.
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Restored from all over the world and well worth a film fans time.Published 6 months ago by Jack Hardy
Decent enough collection of Chaplin's early films. Some appear fairly scratchy but that's only to be expected. Read morePublished 16 months ago by Dean
If you are a die hard Charlie Chaplin fan then you need to add this to your collection. The prints are not that bad.Published 18 months ago by James Licata
Chaplin at Keystone is the recently released four DVD set of all of Chaplin films except one,"Her Friend the Bandit". Read morePublished on October 29, 2013 by Robert Badgley
I've had my eye on this set for a couple of years, and finally purchased it recently. I'm so glad I did! Read morePublished on September 6, 2013 by saskrs
FUNNY, FUNNY, FUNNY!!! He is a magnificent genious who understood timing of comical situations! Brilliant collection! Must have for you who are hard core FANS of Charlie Chaplin. Read morePublished on April 24, 2013 by Smiling!
Boring. I am a fan of the latest Tramp movies, starting with the First National Studios, where he did, among others, "The Idle Class", "A Dog's Life", "The Kid". Read morePublished on December 13, 2012 by Alencar B. P. Fh
|From this Discussion
|amazon a total ripoff
The MSRP (Manufacturer's Suggested Retail Price) is $79.99 -- if anyone is selling it higher than that, it's a ripoff. Amazon is selling it at a very reasonable price, but naturally there will be some places selling it at a loss for much less. Kinda like what Amazon does on a daily basis with... Read More
Oct 14, 2010 by EJ | See all 3 posts


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I own a SQ-B system. This SQ-A system is a steal. Run, do not walk, to the nearest bank and buy it. Assuming everything is in good wofkin order, that is. Even if it's not great cosmetically, it's a great price for a good 'user' system.
If you don't like it, you can re-sell it for a big profit on eBay.


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Dark Shadows
Victoria Winters comes to Collinwood, an isolated mansion in coastal Maine, to work as a governess, but soon finds herself drawn into a strange, Gothic world of vampires, ghosts and a family curse that dates back centuries.
Last Episode01x12 Episode Twelve Aired: Mar. 22, 1991
In 1790, Barnabas' vampirism is discovered. Joshua A. Collins and lawyer Peter Bradford desperately try to save Victoria Winters from being hung …
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Dark Shadows: Season 1, Episode #1 - Episode 1 (Pilot)
Life and death will never be the same again when the mysterious stranger, Barnabas Collins, appears in…
Dark Shadows: Season 1, Episode #2 - Episode 2
Woodard suspects the killer is a vampire, Daphne bites Joe and Woodard drives a stake into her heart.
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Coming into an isolated mansion in Maine to work as a governess, Victoria Winders is drawn into a world of the…
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- VHS editions that were released in the 1990s had an extended pilot episode and extended final episode. The U.S. DVD set are the aired versions.


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Dr. Benita Caldwell specializes in general dentistry in Coralville, Iowa.
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The workshop took place in Bangkok, Thailand, from 4-5 March 2009. The Asian mercury storage project inception workshop aimed to reduce the eventual supply of mercury to the biosphere by initiating a regional process that will support the sequestration of excess mercury in the Asian region. The workshop was successful in the delivery of its objectives.
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|Philip A. Klinkner is an Assistant Professor of Government at Hamilton College in Clinton, New York. He received his B.A. from Lake Forest College in 1985 and his Ph.D. from Yale University in 1992. During 1990-91 he was a Governmental Studies Research Fellow at the Brookings Institution in Washington, D.C. From 1991 to 1995, he taught at Loyola Marymount University in Los Angeles. He is the author of The Losing Parties: Out-Party National Committees, 1956-1993. In 1995 he received the Emerging Scholar Award from the Political Organizations and Parties Section of the American Political Science Association.
|Joseph Cammarano is an Assistant Professor of Political Science at Syracuse University's Maxwell School of Citizenship and Public Affairs. He has conducted research and published articles in political communication and political campaigning. His current research focuses on political accountability in an era of candidate-centered politics.
|William F. Connelly Jr. is an Associate Professor of Politics at Washington and Lee University in Lexington, Virginia. With John J. Pitney, Jr., he coauthored Congress' Permanent Minority?: Republicans in the U.S. House. He was an American Political Science Association Congressional Fellow in 1985-86 and Guest Scholar at the Brookings Institution during 1991-92.
|Theodore J. Eismeier is the James L. Ferguson Professor of Government at Hamilton College. He is the author with Philip H. Pollock of Business, Money, and the Rise of Corporate PACs in American Politics, and is currently completing a book on political leadership.
|Paul Frymer received his Ph.D. from Yale University in 1995. He is currently a visiting professor at the University of California, Los Angeles. He has written on divided government, political parties, and the politics of race in America.
|Elizabeth Ivry is a government major at Colby College, Waterville, Maine.
|Gary C. Jacobson is Professor of Political Science and Chair of the department at the University of California, San Diego, where he has taught since 1979. He received his A.B. from Stanford in 1966 and his Ph.D. from Yale in 1972, both in


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Stars of the Newly Announced Fall TV Lineup
- Photo: Jacquelyn Martin/Invision/AP11 of 13
Kelsey Grammer in "Hank": Kelsey is an old hand at the TV game, and a new sitcom with him is now a pretty standard part of any upcoming TV line-up. This time he plays an industry big-wig who loses his job. If that logline doesn't sound terribly inspired to you, let's just say: "Kelsey Grammer. Upper-class guy. Gets knocked down a peg. Laugh track." Done and done.
Get out the vote
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By Nicole Neroulias
Religion News Service
Wednesday, March 24, 2010; 10:52 AM
Preparing for Passover? There's an app for that. Several, actually.
Jewish technophiles have created a host of online and iPhone applications that put a modern spin on the traditional Seder meals, storytelling and singing associated with the weeklong celebration of the biblical exodus from Egypt.
To help Jews stock their pantries with kosher for Passover foods, which cannot contain yeast, a new iPhone app called My Grocery Master searches supermarket inventories by zip code. The program debuted to mixed reviews over its $4.99 annual fee and selection limitations, but improvements have been made in response to user feedback.
"We will continually be updating our database with new products and tailoring the application for more diet types," said Steven M. Friedman, MyGroceryMaster.com president, whose program can also find groceries that are vegan, organic, gluten- and lactose-free.
The iMah Nishtanah app helps users ask the ceremonial four questions in perfect Hebrew, with a record mode that lets them rehearse the readings and songs before going public at the Seder.
"Mobile devices are a perfect platform for language acquisition," said Jeremy Poisson of Behrman House, a publishing house that helped develop this and other Hebrew programs. "The mobility allows users to learn, play, or practice anywhere." Even the plagues have gone viral, thanks to a group of rabbis using Twitter to tell the Passover story through messages from characters such as God--of--Israel, Slavedrivers, and PharoahofEgypt, with dialogue and links tailored for the program's 140-character limit.
More than 1,100 followers have signed up to receive "Tweet the Exodus" updates, which will culminate with the crossing of the Red Sea on Monday, just before the first Passover meal begins.
After seeing the Nile's water turn to blood, the skies rain down frogs, lice and flies, and their cattle drop dead, citizensofegypt responded to the ancient plague of "unhealable boils" with a sly nod to current events: "Our skin is boiling; turn up the AC! Oh no, that's not helping. . . If only Pharoah provided universal health care. . ." For more information, visit www.twitter.com/tweettheexodus.
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Steely Library phone number: 859.572.5457
What is a Literature Review?
While the term literature is often used to refer to fictional works such as novels and plays, in the academic world, literature can also have a different meaning. If your professor has asked you to review the literature or write a literature review paper, he or she probably does not want you to read novels and plays.
When scholars talk about the "literature" they are often referring to the collected body of academic works related to a topic. For example, a chemist may speak of the "scientific literature," referring to scholarly writing published by other scientists. In most cases, the literature consists of non-fiction books or scholarly articles published in academic journal. More rarely, other types of sources, such as a blog post written by a scholar, might also be considered part of the literature, although you should be careful of including non-traditional sources in a literature review without approval from your professor.
When you need to review the literature or to write a literature review, the goal is to identify, locate, summarize, and analyze a variety of sources containing information related to your field or research topic.
Why review the literature?
There are many reasons why you might need to review the literature:
- You may need to review the literature in order to keep up to date in your field. Reviewing the literature helps you to identify the most significant research in your area and to recognize current trends. This can also help you to identify new topics to research.
- For most research papers, you are required to include a literature review section. In this part of the paper, you discuss and analyze previous research related to your topic in order to show how this research guides or supports your own research. This section provides the context for your research.
What is a Literature Review Paper?
In some cases, the term "literature review" can refer to a specific kind of paper. The sole purpose of this type of paper is to review and analyze the literature related to a specific topic. The author of this type of paper does not conduct any additional research project, instead, their goal is to select a number of different sources related to a particular topic and to summarize and evaluate the findings. For example, a nursing student who is studying techniques for IV insertion in pediatric patients may select the 15 most recent articles on the topic and analyze these articles to determine trends or best practices.
How do you conduct a review of the literature?
After you have identified your topic, you begin your search for sources related to that topic. In some cases, you may be looking for only the most recent literature on a topic while in other cases you may be looking for the most prominent sources or for sources that fit certain parameters.
Your initials searches may be fairly broad, but as you read and analyze you will be able to discard sources that don't relate closely enough to your topic.When you do find a book or article that is really relevant, one trick is to use the references in that source to find additional sources.
How do I locate the literature in my field?
There are many options for finding books and articles related to your topic, including Discovery, subject specific databases, WorldCat, and SourceFinder.
Discovery is a tool that searches multiple databases, including NKUIRE (the library's catalog). In addition, there are approximately 150 databases available through Steely Library. Many of them are subject oriented and will provide full-text access to journal articles. Using these databases will provide you with the most current research related to your topic. The databases are available to you on or off campus.
Another source for finding books, videos, and other items is WorldCat. WorldCat is the world's most comprehensive bibliography and includes holdings information from libraries across the world. Request any item NKU does not own using SourceFinder
How do I organize my information?
RefWorks is an online research management, writing and collaboration tool, designed to help researchers easily gather, manage, store and share all types of information, as well as generate citations and bibliographies. Several tutorials and guides are available that explain how to use Refworks.
Steely Library phone number: 859.572.5457


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Justin Timberlake, Jessica Biel Marry in Italy!
Congratulations to the new Mr. and Mrs. Timberlake!
After a 10-month long engagement, Justin Timberlake and Jessica Biel tied the knot in southern Italy on Friday, Us Weekly has learned.
PHOTOS: Jessica Biel's best white dresses ever!
The "Sexy Back" singer, 31, popped the question with a vintage-style, six-carat engagement ring, which he designed, over the holidays in December 2011. (Us broke the news in January.) Said a source of why the spot is special for the couple: "Justin knows how much she loves snowboarding and the mountains, so it was the perfect place."
PHOTOS: Jessica Biel's hottest, most revealing body moments
It has been a long road to the altar for the longtime loves, who have dated off and on for nearly five years. But after a brief three-month split in 2011, Biel made it clear that she wanted to spend her life with Timberlake "When they reunited, they had a conversation about taking the next step," the insider added.
VIDEO: Jessica Biel flashes her giant engagement ring!
It's the first marriage for both Biel and Timberlake, whose past serious girlfriends include Britney Spears and Cameron Diaz.
This article originally appeared on Usmagazine.com: Justin Timberlake, Jessica Biel Marry in Italy!
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Captain America: The Winter Soldier pre-release thread
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October 24 2012, 05:01 PM
Flying Spaghetti Monster
Vice Admiral
Location: Flying Spaghetti Western
Re: Captain America: The Winter Soldier pre-release thread
Of course the bluetooths were not visible on Cap, BW or anyone else, really. It looked more like they magically talked to each other. And yes, I noticed that it looks like the Avengers only stayed on a single street. Pretty damn obvious.
I also wonder why Stark didn't take "Legolas" to the top of the tower to deactivate the portal; when BW went there in a much riskier fashion they were no closer to figuring out how to close it anyway.
Also, this is a separate point, but all the Avengers spent an inordinate amount of time trying to figure out where the tesseract was, when it was obvious that it would be Stark's tower
No more adventures! I'm not going that way!
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text: hi, i torture my rear wheel alot and snakebites occur. Is there a 20" tyre out there that is for trials, and also i know the specialized evil twin 2.2 is like what im talking about but its outta sale. Polz can someone tell me if one fits my specifications and tell ,me where to buy one online


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Gillette Stadium Becomes The Wall From Game Of Thrones [PHOTO]
I think the people of Foxborough should be on the look out for white walkers, cause Gillette Stadium has turned into The Wall from Game of Thrones in all this snow!
I think the people of Foxborough should be on the look out for white walkers, cause Gillette Stadium has turned into The Wall from Game of Thrones in all this snow!
Has a manlier headline ever existed? I think not.
In Canada, there are pretty much entire industries based on snow removal. Roadways, runways, and even railways need to be kept as clear as possible for commerce and transportation to resume...
Ice is a staple in my household and I am looking to find some restaurant quality type of ice.
Its not often it snows in Atlanta Georgia, so when it does, you can imagine what happens on the roadways. We are pros here on the southcoast of course...
You really do have to love a happy ending and good timing! A lieutenant from the Bourne Fire Department saved a dog trapped on Queen Sewell Pond this morning.
Driving in snow is just second nature to me now. Still, it doesn't matter if your a great driver or a bad one, a new driver or an experienced one, poor weather conditions can test your nerves and skills on the road.
This video of a cute baby walking on ice for the first time originated in Russia, but has gone viral world wide.
Now, before you are tempted to make a comment, the child was not injured at all, its just described as cute...
Two foreign nationals have been arrested on immigration violations in New Bedford where police say the surviving Boston Marathon bombing suspect may have once lived.
Yeah, when I first read the title, I also didn't really know what to think. In fact, this phenomenon in actually happening.
Hello New England!! It is 60 outside right now!! Rain and a bunch of it moves in tonight and tomorrow. Then on Thursday Night very late, the temperature will drop 30 degrees


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comments sponsored by
Celebrities, Drugs, Immigration, Non-Sequiturs, Sex, Television
* While Gawker seems obsessed with the social-climbing aspiration of ex-Skaddenite Melissa Berkelhammer, hopefully we'll soon find out what makes her any worse than the others. [Page Six via Socialite Rank]
* Denmark let the little mermaid stay, and yet they won't let foreign-born spouses of Danish nationals cross the "Love Bridge." [Bloomberg].
* Lovin' might be a mistake, but it's worth making. (Sorry we didn't cover the Hilary Duff stalker story, but there are some celebrity stories even we don't care about.) [AP via Yahoo! News]
* Something(s) undoubtedly went down, but it couldn't have been as bad as this. Please, Dr. Huxtable, say it ain't so. [AP via NY Lawyer]
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It's always pool time with the Pool Rack Quartz Clock - 12.63 in. donning your beloved game room wall. Framed in a wood triangle rack, this quartz clock counts the hours with the iconic billiard balls. The perfect way to mark the house on those long pool sessions, this trusty analog clock runs on one AA battery (not included).About Trademark Global Inc.Located in Lorain, Ohio, Trademark Global offers a vast selection of items for your home and lifestyle. Whether you need automotive produ


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Joseph Hatch
- Filed Under
Ulster Insurance Services names vice president - Ulster Insurance Services Inc., a subsidiary of Ulster Savings Bank, has named Joseph P. Hatch of Pine Bush as vice president of insurance operations.
Hatch, a 42-year insurance industry veteran, returns to Ulster Insurance Services after serving as an account executive from 2001 to 2009. For the past three years, he operated his independent insurance agency, J.P. Hatch LLC, and served as a consultant to other independent insurance agencies outside of New York state.
In addition to its banking operations, Ulster Savings Bank has Ulster Insurance Services Inc. and Ulster Financial Group Inc. as its subsidiaries.
Fishkill technology firm wins award - Bionic Eye Technology of Fishkill was recently honored by Biomedical Engineering Alliance and Consortium, a nonprofit trade association for the medical device industry.
The annual medical technology award is presented to an individual or organization-corporation in recognition of significant advancement in the development and either the commercialization or manufacturing of new medical technology or both.
Bionic Eye Technology Inc. is a privately held medical device developer and manufacturing company focused on devices featuring its patented design.
It was founded in 2011 by John Wyatt and Joseph Rizzo.
Continuing education discount offered - The New York State Society of CPAs' Foundation for Accounting Education has launched a new discount program that gives more continuing education options for small- to medium-size CPA firms.
The new FAE Value Pass allows firms to choose between a 40-credit or 80-credit discount pass.
More savings can be realized if firms take advantage of the early bird special, which runs through Dec. 31.
For more information, visit www.nysscpa.org/faevp or call 800-537-3635.


text: 2. Under-marketing the advantage of flexible packaging. In 2008, Unilever experimented with Ragu and Bertolli brand pasta sauces in a pouch. The pouch eliminated breakage concerns associated with glass, was microwavable right in the package, and resulted in less waste for the consumer to discard. But the pouches were at a higher price point than the jars displayed right next to them. Some industry experts feel that the package might have caught on had Unilever marketed these advantages to consumers right on the package. Tip: Consider lowering the price of a product in a new flexible package to entice consumers to abandon the legacy package format.


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I was inspired by ICIP 2015 and by the new graph functions in MATLAB R2015b to write some functions to help experiment with graph-based image processing algorithms. Earlier this week I submitted the code to the File Exchange. Here's a screen shot:... read more >>
Graphs in MATLAB R2015b 1
Posted by Steve Eddins,


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Kentucky extends Mark Stoops' contract through 2018-19
Kentucky has extended Mark Stoops contract through the 2018-19 season, the school announced on Tuesday.
The Wildcats finished 2-10 in Stoops' first season as head coach without a single win in SEC play, but fans were able to celebrate in February when Kentucky signed one of its highest-ranked recruiting classes ever (No. 22 nationally in the 247Sports Comosite).
"We are excited about the enthusiasm and recruiting success that Mark and his staff have brought to our football program," athletic director Mitch Barnhart said in an official release. "We had the nation's second-largest increase in attendance last season and we have had the two largest spring-game attendances in school history (in 2013 and 2014).
"In recruiting, Mark and his tireless assistant coaches have made an obvious impact with their first two classes and that momentum is carrying forward for 2015."
According to Kyle Tucker of The Courier-Journal, the extension will include a raise for Stoops in the final two seasons of the deal. Stoops will make $2.1 million for the 2014-15 season.
UK spokesman tells me Stoops' extended deal includes raise for the final two seasons, to $2.5 million in 2017-18, $2.65 million in 2018-19.— Kyle Tucker (@KyleTucker_CJ) May 6, 2014
Stoops' new deal runs through June 30, 2020. While the on-field results have yet to be realized, Stoops has taken steps forward with an increase in attendance and the approval of a $110 million renovation to Commonwealth Stadium as some of his early calling cards.


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text:
Dave Engledow, Pittsburg, has something new to be grateful for this Thanksgiving.
Dave Engledow, Pittsburg, has something new to be grateful for this Thanksgiving.
After undergoing extensive testing and risky brain surgery, he just might be cured of epilepsy. At any rate, he hasn't experienced a seizure since having the operation on Oct. 13 at the University of Kansas Medical Center.
They had been with him since childhood. Epilepsy can have many causes, including birth defects, infections in the brain and traumatic injuries to the brain at any age. Engledow said that his was probably caused by hitting his head in a fall.
"My brother says that I fell and hit the concrete sidewalk when I was 6 or 7," he said. "When I was in school I'd hide behind trash cans when I had a seizure because people laugh at you. I don't have to deal with that now."
Engledow is grateful to his surgeon, Darren S. Lovick, MD, assistant professor at the KU Medical Center.
"He called me his little guinea pig," Engledow said.
His wife, Pat, much prefers to call him a pioneer.
"They went in and took out a piece of the lobe, a tiny piece where the seizures initiate," Mrs. Engledow said.
It took tests to pinpoint the piece that needed to be removed.
"They cut two holes in the back of my head for probes," Engledow said. "They took away all my medications that stop seizures."
Hospital staff also wouldn't let him have any blankets or sheets when he slept because they wanted to be able to observe any seizures he had.
The problem site was located, and Engledow, his head shaved, was wheeled into surgery at 7:30 a.m. Oct. 13.
"He was in surgery between four and five hours," Mrs. Engledow said.
"They took out a piece of tissue about the size of a silver dollar on the left side of my brain," her husband said. "I was in ICU for three days, at the KU Medical Center for 2 1/2 weeks and then they let me go to Girard Medical Center and Dr. Ron Edwards took over. It was a rough trip."
"He was in a lot of pain after the surgery, and conked out on medication," Mrs. Engledow said. "They'd check his orientation status, and ask him things like what his name was, where he was, why he was there, who's president. Sometimes he got the answers right and sometimes he didn't."
The rough trip isn't quite over yet. There are still some after effects from the surgery.
"The biggest thing I've noticed is some issue with remembering certain words and names," Mrs. Engledow said. "At the hospital they said this would improve with time, as the other side of the brain takes over for what's missing."
Page 2 of 2 - She's already seeing improvements.
"His humor and joking are back, and they weren't there right after the surgery," Mrs. Engledow said. "When he had the probes in his head his demeanor was very different. He was cranky with everybody, and one of my big worries was that when he had the surgery he would be like that permanently. I didn't want to trade this guy for Mr. Crab."
She said that her husband is gaining strength daily, which is good but also causes some problems.
"We have to keep on his case to keep him from bending over and doing things he normally could do but can't do right now," Mrs. Engledow said.
"I tried bending over and started to have an aura like I'd have before a seizure," Engledow said.
"I don't think picking up something off the floor is worth undoing what we've worked for two years and you going back to having seizures," his wife replied. "And remember that this is very temporary."
Right now Engledow is doing physical therapy, and said he's troubled by a weakness in his left hand. His surgeon has told him to come back to the medical center for an MRI and spinal studies.
"There's a doctor who cares about his people," Engledow said. "I'd recommend him to anybody, and also Dr. Edwards and the people at Girard Medical Center."
He's bored, but occasionally takes his wife's wheelchair and sits on the sidewalk to watch cars go by. He hopes he'll be driving again soon.
"One of the doctors said that if everything goes all right, in six months I'll be able to get a driver's license again," Engledow said.
"I think it's just shy of 20 years since the last time he had a license," Mrs. Engledow said.
After he's back on his feet, her husband plans to resume having meetings of the Southeast Kansas Epilepsy Support Group, which he founded and leads. He's been talking with Danielle Walk, program director for the Epilepsy Foundation of Missouri and Kansas, and wants to educate the public about epilepsy. Engledow doesn't want people to laugh at those with epilepsy; he does want everyone to know how to respond if a student, classmate or bystander suffers a seizure,
He's also on a crusade for safer sidewalks in Pittsburg for those in wheelchairs or suffering mobility issues, and would like it if the PACT bus started making stops at the Besse Hotel again.
"I'm just trying to figure out how to do right for other people," he said.
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Author Elisabeth Elo: North of Boston
North of Boston is a riveting debut thriller set on the gritty Boston Waterfront featuring Pirio Kasparov, who survives a ship sinking in cold Atlantic waters but whose captain does not. Pirio becomes suspicious that the "accident" was no accident and is determined to find the truth. In doing so, the story slowly builds into something larger and more disturbing.
Elisabeth Elo grew up in Boston. She worked as an editor, an advertising copywriter, a high-tech project manager, and a halfway house counselor before getting a PhD in American Literature at Brandeis University. Since then, she's taught writing and literature in the Boston area. Her essays and short stories have appeared in a variety of publications.
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Shine On: The Ultimate Collection en
Shine On: The Ultimate Collection is a digitally remastered two-disc greatest hits compilation album of American singer Laura Branigan. It is the Grammy-nominated vocalist's first multi-disc collection and her first music video compilation. It was released on June 15, 2010 by Gallo and Warner Music in South Africa and is available as an import in other regions through Branigan's official website. Nearly all the tracks on the first disc are edited versions. The first disc is an 18-track CD featuring Branigan's biggest hits, including international hit singles "Gloria" and "Self Control" along with rarer songs such as fan-favorite "Forever Young", from the long out-of-print 1985 album Hold Me, and the two recordings recorded for her 1995 collection The Best of Branigan, "Show Me Heaven" and "Dim All the Lights". Branigan's vocal performance of "Gloria" received a 1982 Grammy Award nomination for Best Pop Vocal, Female. The second disc is a DVD featuring all except one of Branigan's Atlantic Records music videos, including the 1984 "Self Control" clip helmed by Academy Award-winning director William Friedkin. [ - ]
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Publications (17)58.13 Total impact
Article: Enantioselective induction of SIRT1 gene by syringaresinol from Panax ginseng berry and Acanthopanax senticosus Harms stem[Show abstract] [Hide abstract]
ABSTRACT: Syringaresinol exists either exclusively as one enantiomer or enantiomeric mixtures in plant foods. We found that (+)-syringaresinol, but not (-)-syringaresinol, upregulates silent information regulator two ortholog 1 (SIRT1) gene expression, and thus, Panax ginseng berry with predominantly high contents of (+)-syringaresinol exhibits higher activity in inducing SIRT1 gene expression than Acanthopanax senticosus Harms stem with almost equal proportion of the two enantiomers. These findings highlight the importance of the absolute configuration of syringaresinol for the biological activity.Bioorganic & Medicinal Chemistry Letters 11/2014; 25(2). DOI:10.1016/j.bmcl.2014.11.045 · 2.42 Impact Factor
Article: Transcriptional activation of melanocortin 2 receptor accessory protein by PPARγ in adipocytes[Show abstract] [Hide abstract]
ABSTRACT: Adrenocorticotropic hormone (ACTH) in rodents decreases lipid accumulation and body weight. Melanocortin receptor 2 (MC2R) and MC2R accessory protein (MRAP) are specific receptors for ACTH in adipocytes. Peroxisome proliferator-activated receptor γ (PPARγ) plays a role in the transcriptional regulation of metabolic pathways such as adipogenesis and β-oxidation of fatty acids. In this study we investigated the transcriptional regulation of MRAP expression during differentiation of 3T3-L1 cells. Stimulation with ACTH affected lipolysis in murine mature adipocytes via MRAP. Putative peroxisome proliferator response element (PPRE) was identified in the MRAP promoter region. In chromatin immunoprecipitation and reporter assays, we observed binding of PPARγ to the MRAP promoter. The mutagenesis experiments showed that the -1209/-1198 region of the MRAP promoter could function as a PPRE site. These results suggest that PPARγ is required for transcriptional activation of the MRAP gene during adipogenesis, which contributes to understanding of the molecular mechanism of lipolysis in adipocytes.Biochemical and Biophysical Research Communications 08/2013; 439(3). DOI:10.1016/j.bbrc.2013.08.061 · 2.30 Impact Factor
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ABSTRACT: Abbreviations: FCCP, carbonyl cyanide (p-trifluoromethoxy)-phenylhydrazone; HDF, human dermal fibroblasts; JNK, c-Jun N-terminal kinases; MMP-1, Matrix metalloproteinase-1; SA-βgal, senescence-associated β-galactosidaseJournal of Investigative Dermatology 08/2013; 134(2). DOI:10.1038/jid.2013.352 · 7.22 Impact Factor
Article: Chitooligosaccharide Induces Mitochondrial Biogenesis and Increases Exercise Endurance through the Activation of Sirt1 and AMPK in Rats[Show abstract] [Hide abstract]
ABSTRACT: By catabolizing glucose and lipids, mitochondria produce ATPs to meet energy demands. When the number and activity of mitochondria are not sufficient, the human body becomes easily fatigued due to the lack of ATP, thus the control of the quantity and function of mitochondria is important to optimize energy balance. By increasing mitochondrial capacity? it may be possible to enhance energy metabolism and improve exercise endurance. Here, through the screening of various functional food ingredients, we found that chitooligosaccharide (COS) is an effective inducer of mitochondrial biogenesis. In rodents, COS increased the mitochondrial content in skeletal muscle and enhanced exercise endurance. In cultured myocytes, the expression of major regulators of mitochondrial biogenesis and key components of mitochondrial electron transfer chain was increased upon COS treatment. COS-mediated induction of mitochondrial biogenesis was achieved in part by the activation of silent information regulator two ortholog 1 (Sirt1) and AMP-activated protein kinase (AMPK). Taken together, our data suggest that COS could act as an exercise mimetic by inducing mitochondrial biogenesis and enhancing exercise endurance through the activation of Sirt1 and AMPK.PLoS ONE 07/2012; 7(7):e40073. DOI:10.1371/journal.pone.0040073 · 3.23 Impact Factor
Article: An Ethanol Extract of Artemisia iwayomogi Activates PPARδ Leading to Activation of Fatty Acid Oxidation in Skeletal Muscle[Show abstract] [Hide abstract]
ABSTRACT: Although Artemisia iwayomogi (AI) has been shown to improve the lipid metabolism, its mode of action is poorly understood. In this study, a 95% ethanol extract of AI (95EEAI) was identified as a potent ligand of peroxisome proliferator-activated receptorδ (PPARδ) using ligand binding analysis and cell-based reporter assay. In cultured primary human skeletal muscle cells, treatment of 95EEAI increased expression of two important PPARδ-regulated genes, carnitine palmitoyl-transferase-1 (CPT1) and pyruvate dehydrogenase kinase isozyme 4 (PDK4), and several genes acting in lipid efflux and energy expenditure. Furthermore, 95EEAI stimulated fatty acid oxidation in a PPARδ-dependent manner. High-fat diet-induced obese mice model further indicated that administration of 95EEAI attenuated diet-induced obesity through the activation of fatty acid oxidation in skeletal muscle. These results suggest that a 95% ethanol extract of AI may have a role as a new functional food material for the prevention and/or treatment of hyperlipidermia and obesity.PLoS ONE 03/2012; 7(3):e33815. DOI:10.1371/journal.pone.0033815 · 3.23 Impact Factor
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ABSTRACT: Chitooligosaccharides (COS), a kind of oligosaccharide made from chitin or chitosan, have been used a popular remedy for hangovers. In this study we investigated the in vitro effect of COS lactate salt on ethanol-induced cytotoxicity and the in vivo effect of short-term COS lactate salt feeding on ethanol-induced hangover. Pretreatment of HepG2 cells with COS lactate salt significantly reduced ethanol-induced cytotoxicity and suppressed generation of reactive oxygen species. In addition, COS lactate salt dose-dependently increased acetaldehyde dehydrogenase (ALDH) activity in vitro and reversed the ALDH inhibition induced by daidzin. Furthermore, oral administration of COS lactate salt (200 mg/kg) for 5 days significantly decreased the blood levels of alcohol and acetaldehyde in ethanol-treated mice. It was also demonstrated that hepatic mitochondrial ALDH activity was significantly increased in COS lactate salt-treated mice. Taken together, these findings indicate that COS lactate salt may have efficacy for the management of alcoholic hangovers.Journal of medicinal food 10/2010; 13(5):1061-8. DOI:10.1089/jmf.2009.1323 · 1.63 Impact Factor
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ABSTRACT: Chitooligosaccharides (COS), oligosaccharides composed of two to seven glucosamine residues, are known to exhibit various biological activities. In this study, we investigated the effects of COS in an in vivo mouse sleep deprivation-induced fatigue model in an effort to develop a functional food with anti-fatigue efficacy. Male Balb/c mice were orally administered 500 mg (kg d)(-1) of COS lactate or COS HCl for 2 weeks, and severe fatigue was induced by sleep deprivation. To evaluate the extent of fatigue, the swimming time, representing the immobility time, was measured in a forced swim test. As a result, oral intake of COS lactate-manifested anti-fatigue effects could be observed by the attenuation of fatigue-induced body weight loss and shorter immobility period. In addition, COS lactate was shown to alleviate the fatigue-induced increase in cortisol and lipid peroxidation and a decrease in superoxide dismutase (SOD) activity. Of particular note, the oral administration of COS lactate increased the mitochondrial membrane potential and the mitochondrial number significantly, indicating that COS lactate may enhance mitochondrial function. In support of this, COS lactate increased the expression of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) and cytochrome c (Cyt C) mRNA, indicating that it may increase mitochondrial biogenesis. These results suggest that COS lactate can be an effective anti-fatigue functional food, and this anti-fatigue effect may result from, at least in part, the enhancement of mitochondrial biogenesis and the inhibition of free radical generation.Biological & Pharmaceutical Bulletin 01/2010; 33(7):1128-32. DOI:10.1248/bpb.33.1128 · 1.83 Impact Factor
Article: Proteomic analysis of mitochondrial proteins of basal and lipolytically (isoproterenol and TNF-α)-stimulated adipocytes[Show abstract] [Hide abstract]
ABSTRACT: The regulation of adipocyte lipolysis is increasingly believed to influence insulin resistance, in a process that may be associated with mitochondrial dysfunction. However, the molecular basis of the relationship between mitochondrial protein expression, lipolytic responsiveness, and insulin resistance remains unknown. A set of proteins that shows altered abundances in the mitochondria of untreated and treated 3T3-L1 adipocytes with TNF-alpha or isoproterenol was identified. These include the proteins associated with energy production, including fatty acid oxidation, TCA cycle, and oxidative phosphorylation. Proteins associated with oxidative stress dissipation were down-regulated in lipolytically stimulated adipocytes. Lipolytic stimulation with isoproterenol and TNF-alpha, which is also a potent proinflammatory cytokine, showed some noticeable differences in mitochondrial protein expression. For example, isoproterenol markedly enhanced the expression of prohibitin which is involved in the integrity of mitochondria but TNF-alpha did not. These results provide valuable information on mitochondrial dysfunction associated with oxidative stress induced by lipolytic stimulation.Journal of Cellular Biochemistry 02/2009; 106(2):257-66. DOI:10.1002/jcb.21998 · 3.26 Impact Factor
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ABSTRACT: Cidec is a lipid droplet-associated protein, which inhibits lipolysis, leading to the accumulation of triglycerides in adipocytes. However, the transcriptional regulation of Cidec in adipocyte remains unknown. In the present study we investigated that the mouse Cidec transcript is regulated by PPARgamma2. After the differentiation of adipocyte, the expression pattern of Cidec was similar to that of PPARgamma2. In the presence of a PPARgamma agonist, the level of Cidec mRNA was highly increased. In addition, putative PPRE sites were identified in the Cidec promoter. By chromatin immunoprecipitation assay and reporter assay, we observed the binding of PPARgamma2 to the promoter of Cidec. Gel shift assay and the mutagenesis study were showed that the -219/-207 region of the Cidec promoter could function as a PPRE of the Cidec promoter. These results suggest that PPARgamma2 is required for the transcriptional activity of Cidec during adipogenesis, which could be contributed to understand the molecular mechanism of lipid droplet formation in adipocytes.Biochemical and Biophysical Research Communications 11/2008; 377(1):297-302. DOI:10.1016/j.bbrc.2008.09.129 · 2.30 Impact Factor
Article: Shin, E. S. et al. Catechin gallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme. Bioorg. Med. Chem. 16, 3580-3586[Show abstract] [Hide abstract]
ABSTRACT: Recent studies have shown that glucose-6-phosphate dehydrogenase (G6PD) is an effectual therapeutic target for metabolic disorders, including obesity and diabetes. In this study, we used in silico and conventional screening approaches to identify putative inhibitors of G6PD and found that gallated catechins (EGCG, GCG, ECG, CG), but not ungallated catechins (ECG, GC, EC, C), were NADP(+)-competitive inhibitors of G6PD and other enzymes that employ NADP(+) as a coenzyme, such as IDH and 6PGD.Bioorganic & medicinal chemistry 05/2008; 16(7):3580-6. DOI:10.1016/j.bmc.2008.02.030 · 2.79 Impact Factor
Article: Identification of the domains required for the localization of Prp19p to lipid droplets or the nucleus[Show abstract] [Hide abstract]
ABSTRACT: Prp19p is a protein found in the nucleus, cytosol or lipid droplets depending on the cell type. Prp19p participates in pre-mRNA splicing, in neuronal/astroglial cell fate decisions or in adipocyte lipid droplet biogenesis. In this study, the motifs of Prp19p that are necessary for its localization to lipid droplets or the nucleus in 3T3-L1 adipocytes are investigated using a series of truncated mutants of Prp19p that were fused to EGFP and transiently introduced into differentiated 3T3-L1 adipocytes. Immunofluorescence microscopy revealed that a domain of amino acids 167-250 is necessary for the recruitment of Prp19p to lipid droplets and that a domain of amino acids 1-166 is necessary for the recruitment of Prp19p to a nucleus.Biochemical and Biophysical Research Communications 01/2008; 364(4):844-9. DOI:10.1016/j.bbrc.2007.10.091 · 2.30 Impact Factor
Article: Combination of caffeine, arginine, soy isoflavones, and L-carnitine enhances both lipolysis and fatty acid oxidation in 3T3-L1 and HepG2 cells in vitro and in KK mice in vivo[Show abstract] [Hide abstract]
ABSTRACT: To develop an anti-obesity agent containing dietary components, we focused on the mechanisms that enhance both lipolysis and fatty acid oxidation. Caffeine and arginine (CA), a nonselective adenosine-receptor antagonist and an inducer of lipolytic hormone, respectively, were used to stimulate lipolysis. Soy isoflavones and L-carnitine (SL), stimulators of carnitine palmitoyl transferase 1A and a cofactor for beta-oxidation of fatty acids, respectively, were used to enhance fatty acid oxidation. Effects of a combination of CA and SL (CASL) on lipid metabolism were studied in vitro and in vivo. During 3T3-L1 differentiation, lipid accumulation was significantly lower in cells treated with CASL (50 micromol/L, 1 mmol/L, 1 micromol/L, and 1 mmol/L, respectively) compared with each alone. Lipolysis was also significantly greater in 3T3-L1 adipocytes treated with CASL (50 micromol/L, 1 mmol/L, 10 micromol/L and 0.5 mmol/L, respectively) compared with each alone. In addition, treatment with higher concentrations of CASL (2 mmol/L, 1 mmol/L, 10 micromol/L, and 1 mmol/L, respectively) significantly enhanced beta-oxidation in HepG2 cells. The effects of CASL-containing diets (250 mg, 6 g, 200 mg, and 1.5 g/kg diet, respectively) were studied in vivo. When KK mice were food deprived for 48 h and subsequently refed a fat-free diet for 72 h, hepatic triglyceride (TG) accumulation was significantly lower in mice fed CASL compared with the control mice. In addition, after obese KK mice were fed a low-fat diet for 2 wk, adipose tissue weights were significantly lower in those fed CASL, but not CA or SL alone, compared with the control mice. Plasma and liver TG levels were also lower in mice fed CASL than in the control mice. These results suggest that CASL is effective for controlling obesity.Journal of Nutrition 11/2007; 137(10):2252-7. · 3.88 Impact Factor
Article: Genistein downregulates SREBP-1 regulated gene expression by inhibiting site-1 protease expression in HepG2 cells[Show abstract] [Hide abstract]
ABSTRACT: Genistein is one of the most abundant isoflavones in soy. The effects of genistein on cholesterol synthesis and fatty acid oxidation have been well documented, but the effect of genistein on fatty acid synthesis remains unclear. Thus, we investigated the effect of genistein on fatty acid synthase (FAS) expressions in HepG2 cells. In HepG2 cells treated with 10 micromol/L genistein, mRNA and protein expressions of FAS, as well as FAS activity, were significantly decreased. The promoter region of FAS contains binding sites for the transcription factor called sterol regulated element binding protein 1 (SREBP-1); SREBP-1 must be processed by site-1 (S1P) and site-2 proteases to be activated. We also investigated the effects of genistein on S1P, SREBP-1 expression, and subsequent SREBP-1 processing by S1P in HepG2 cells. Genistein reduced the expression of S1P and the processing of SREBP-1 but did not change the expression of SREBP-1 mRNA. SREBP-1 is also a transcription factor for lipogenic genes, such as stearoyl coenzyme-A desaturase1 (SCD1), glycerol-3-phosphate acyltransferase (GPAT), and acetyl-CoA carboxylase (ACC)1, and ACC2. Genistein also significantly inhibited the expression of these lipogenic genes. Thus, genistein treatment of HepG2 cells decreased the expression of lipogenic genes such as FAS, SCD1, GPAT, and ACC, which is, at least in part, mediated through the downregulation of S1P expression and subsequent SREBP-1 proteolytic cleavage.Journal of Nutrition 06/2007; 137(5):1127-31. · 3.88 Impact Factor
Article: (-)-Catechin suppresses expression of Kruppel-like factor 7 and increases expression and secretion of adiponectin protein in 3T3-L1 cells[Show abstract] [Hide abstract]
ABSTRACT: Adiponectin is an adipocyte-specific secretory hormone that can increase insulin sensitivity and promote adipocyte differentiation. Administration of adiponectin to obese or diabetic mice reduces plasma glucose and free fatty acid levels. Green tea polyphenols possess many pharmacological activities such as antioxidant, anti-inflammatory, antiobesity, and antidiabetic activities. To investigate whether green tea polyphenols have an effect on the regulation of adiponectin, we measured expression and secretion levels of adiponectin protein after treatment of each green tea polyphenols in 3T3-L1 adipocytes. We found that (-)-catechin enhanced the expression and secretion of adiponectin protein in a dose- and time-dependent manner. Furthermore, treatment of (-)-catechin increased insulin-dependent glucose uptake in differentiated adipocytes and augmented the expression of adipogenic marker genes, including PPARgamma, CEBPalpha, FAS, and SCD-1, when (-)-catechin was treated during adipocyte differentiation. In search of the molecular mechanism responsible for inducible effect of (-)-catechin on adiponectin expression, we found that (-)-catechin markedly suppresses the expression of Kruppel-like factor 7 (KLF7) protein, which has recently been reported to inhibit the expression of adiponectin and other adipogenesis related genes, including leptin, PPARgamma, C/EBPalpha, and aP2 in adipocytes. KLF7 is a transcription factor in adipocyte and plays an important role in the pathogenesis of type 2 diabetes. Taken together, these data suggest that the upregulation of adiponectin protein by (-)-catechin may involve, at least in part, suppression of KLF7 in 3T3-L1 cells.AJP Endocrinology and Metabolism 05/2007; 292(4):E1166-72. DOI:10.1152/ajpendo.00436.2006 · 3.79 Impact Factor
Article: Mouse homologue of yeast Prp19 interacts with mouse SUG1, the regulatory subunit of 26S proteasome[Show abstract] [Hide abstract]
ABSTRACT: Yeast Prp19 has been shown to involve in pre-mRNA splicing and DNA repair as well as being an ubiquitin ligase. Mammalian homologue of yeast Prp19 also plays on similar functional activities in cells. In the present study, we isolated mouse SUG1 (mSUG1) as binding partner of mouse Prp19 (mPrp19) by the yeast two-hybrid system. We confirmed the interaction of mPrp9 with mSUG1 by GST pull-down assay and co-immunoprecipitation assay. The N-terminus of mPrp19 including U-box domain was associated with the C-terminus of mSUG1. Although, mSUG1 is a regulatory subunit of 26S proteasome, mPrp19 was not degraded in the proteasome-dependent pathway. Interestingly, GFP-mPrp19 fusion protein was co-localized with mSUG1 protein in cytoplasm as the formation of the speckle-like structures in the presence of a proteasome inhibitor MG132. In addition, the activity of proteasome was increased in cells transfected with mPrp19. Taken together, these results suggest that mPrp19 involves the regulation of protein turnover and may transport its substrates to 26S proteasome through mSUG1 protein.Biochemical and Biophysical Research Communications 05/2007; 356(1):175-80. DOI:10.1016/j.bbrc.2007.02.134 · 2.30 Impact Factor
Article: Identification of Mouse Prp19p as a Lipid Droplet-associated Protein and Its Possible Involvement in the Biogenesis of Lipid Droplets[Show abstract] [Hide abstract]
ABSTRACT: Prp19p is an integral component of the heteromeric protein complex (the NineTeen complex) in the nucleus, and it is essential for the structural integrity of NineTeen complex and its subsequent activation of the spliceosome. We identified Prp19p, which has never been reported in relation to any function outside of the nucleus, as a member of proteins associated with lipid droplets. Down-regulation of Prp19p expression with RNA interference in 3T3-L1 cells repressed lipid droplet formation with the reduction in the level of expression of perilipin and S3-12. The levels of expression of SCD1 (stearoyl-CoA desaturase-1), DGAT-1 (acyl-CoA diacylglycerol acyltransferase-1), and glycerol-3-phosphate acyltransferase were also reduced in Prp19p down-regulated cells, and a significant decrease in triglycerides was observed. Unlike perilipin, which is one of the most extensively studied lipid droplet-associated proteins, Prp19p is not essential for cAMP- and hormone-sensitive lipase-dependent lipolysis pathways, even though Prp19p is a component of the lipid droplet phospholipid monolayer, and down-regulation of Prp19p represses fat accretion significantly. These results suggest that Prp19p or Prp19-interacting proteins during lipid droplet biogenesis in adipocytes may be considered as another class of potential targets for attacking obesity and obesity-related problems.Journal of Biological Chemistry 02/2007; 282(4):2456-65. DOI:10.1074/jbc.M608042200 · 4.57 Impact Factor
Article: Ginsenoside F1 Protects Human HaCaT Keratinocytes from Ultraviolet-B-Induced Apoptosis by Maintaining Constant Levels of Bcl-2[Show abstract] [Hide abstract]
ABSTRACT: Ginsenosides, the major active ingredients of ginseng, show a variety of biomedical efficacies such as antiaging and antioxidation. Here, we investigate the protective activity of the ginsenoside F1, an enzymatically modified derivative of ginsenoside Rg1, against ultraviolet-B-induced damage in human HaCaT keratinocytes. Ginsenoside F1 significantly reduced ultraviolet-B-induced cell death and protected HaCaT cells from apoptosis caused by ultraviolet B irradiation. Furthermore, ginsenoside F1 prevented ultraviolet-B-induced cleavage of poly(ADP-ribose) polymerase in HaCaT cells. In search of the molecular mechanism responsible for the antiapoptotic effect of ginsenoside F1, we find that protection from ultraviolet-B-induced apoptosis is tightly correlated with ginsenoside-F1-mediated inhibition of ultraviolet-B-induced downregulation of Bcl-2 and Brn-3a expression.Journal of Investigative Dermatology 10/2003; 121(3):607-13. DOI:10.1046/j.1523-1747.2003.12425.x · 7.22 Impact Factor
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Information Technology
The four departments within the IT division are overseen by the Administrative Staff. The Chief Information Officer, Adam Buchwald, is assisted by the Directors of the four departments. The Chief Technology Officer's role is to align technology vision with academic and fiscal strategy by integrating institutional processes with the appropriate technologies. The Chief Information Officer is also responsible for all aspects of developing and implementing technology initiatives within the organization, maintaining existing enterprise systems, while providing direction in all technology related issues in support of information operations and core college values.
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Identities in the Lesbian World: The Social Construction of Self
Greenwood Press, 1978 - Social Science - 226 pages
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Emergence of Identity as the Research Problem
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Gay and lesbian identity: a sociological analysis
Richard R. Troiden
Snippet view - 1988
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Erotics and Politics: Gay Male Sexuality, Masculinity and Feminism
Tim Edwards
No preview available - 2002