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The development of cardiovascular dysfunction and shock in patients with invasive Bacillus anthracis infection has a particularly poor prognosis. Growing evidence indicates that several bacterial components likely play important pathogenic roles in this injury. As with other pathogenic Gram-positive bacteria, the B. anthracis cell wall and its peptidoglycan constituent produce a robust inflammatory response with its attendant tissue injury, disseminated intravascular coagulation and shock. However, B. anthracis also produces lethal and edema toxins that both contribute to shock. Growing evidence suggests that lethal toxin, a metalloprotease, can interfere with endothelial barrier function as well as produce myocardial dysfunction. Edema toxin has potent adenyl cyclase activity and may alter endothelial function, as well as produce direct arterial and venous relaxation. Furthermore, both toxins can weaken host defense and promote infection. Finally, B. anthracis produces non-toxin metalloproteases which new studies show can contribute to tissue injury, coagulopathy and shock. In the future, an understanding of the individual pathogenic effects of these different components and their interactions will be important for improving the management of B. anthracis infection and shock.
Keywords:Bacillus anthracis; Anthrax; Cell wall components; Lethal and edema toxins; Metalloproteases; Cardiovascular dysfunction; Shock
Recent outbreaks of Bacillus anthracis infection in the United States (US) and Europe have underscored the importance of this bacterium in the developed world [1-4]. Despite aggressive support, mortality rates in these outbreaks have been high; 40% in the 2001 US outbreak of inhalational infection, and 33% in the 2009 outbreak of injectional disease in Scotland [2,4,5]. During these outbreaks, the development of shock in patients has appeared resistant to standard hemodynamic therapy and has been associated with a particularly poor prognosis [1-3]. Therefore, an increased understanding of the mechanisms producing shock during B. anthracis infection will be important for its management.
Evolving research has shown that B. anthracis produces several components potentially important in the pathogenesis of shock, including its two exotoxins (lethal and edema toxins (LT and ET, respectively)), a cell wall and its constituents, and several non-toxin metalloproteases. Notably, although LT and ET have long been a focus in this area of research, newer data have begun to emphasize the role of these non-toxin components. This review highlights recent research directed at the contribution of these different non-toxin and toxin components.
B. anthracis cell wall and its peptidoglycan constituent
Sepsis is thought to typically start as a nidus of infection, followed by bacterial invasion of the blood stream. Bacterial cell wall and other components interact with pathogen recognition receptors (PRRs) on host cells; host defense systems are activated; and inflammatory mediators (for example, cytokines, nitric oxide and oxygen free radicals) are released [6]. While this inflammatory response is an essential part of innate immunity and is necessary for microbial clearance, an excessive response can produce organ injury and shock [7-9]. Growing evidence suggests that B. anthracis infection can elicit this type of maladaptive injurious host inflammatory response (Figure?1A) [10,11].
Figure 1. Overview of basic pathways potentially leading to shock, organ injury and death during B. anthracis infection. A. As Gram-positive bacteria, B. anthracis and its products (for example, cell wall and peptidoglycan) activate host defenses and inflammatory mediator release which are necessary for microbial clearance. However, if this response is excessive it may result in the development of shock, organ failure and death. B. B. anthracis also produces two exotoxins, lethal and edema toxins, which are capable of contributing directly to shock, organ injury and death via diverse mechanisms. C. Lethal and edema toxin also appear capable of subverting critical host defense systems and contributing to the pathogenesis of shock, organ injury and death by limiting microbial clearance. Other mechanisms not depicted in this figure, such as the activation of metalloproteases other than lethal factor, may contribute to shock and organ injury with B. anthracis as well (see text).
While lethal and edema toxins are now recognized not to stimulate excessive inflammation (and may actually suppress it), the vegetative form of B. anthracis has a cell wall comprised largely of peptidoglycan that can promote such inflammation [12-14]. Whole cell wall and/or purified peptidoglycan can interact with toll-like receptors two and six (TLR2/6) and nucleotide-binding oligomerization domains 1 and 2 (NOD1 and 2) proteins [15,16]. They can also stimulate host release of TNF?, IL-1? IL-6 and other inflammatory mediators [17]. In rats, in contrast to LT or ET, purified B. anthracis cell wall or its peptidoglycan component alone can stimulate a robust inflammatory response with resultant tissue injury, shock, disseminated intravascular coagulation and lethality [18,19]. Relevant to these findings, B. anthracis peptidoglycan can activate platelets through complement activation [20]. The potential pathogenic role of cell wall takes on added importance based on the observation that patients and animals dying from B. anthracis frequently have very high bacterial loads [2,13,19]. Therefore, while much attention has been devoted to the unique roles LT and ET have in the pathogenesis of B. anthracis, this Gram-positive bacteria can also produce shock and organ injury via mechanisms common to other types of bacteria.
Lethal and edema toxin structure and intracellular effects
Lethal and edema toxins are each binary type exotoxins comprised of protective antigen (PA) and the toxic moieties lethal factor (LF) and edema factor (EF) [14,21,22]. During infection, PA binds to host cells via one of two receptors: tumor endothelial marker 8 (TEM8) or capillary morphogenesis gene-2 (CMG2) [23-25]. These receptors are abundant on endothelial cells and in a variety of tissues [14]. PA binding is necessary for host cell uptake of LF and EF. LF inactivates mitogen-activated protein kinase kinases 1 to 4, 6 and 7 (MAPKKs) [21,22]. Recent data also show that LF activates the Nlrp1 inflammasome in macrophages and dendritic cells causing activation of caspase-1 and the production of IL-1? and IL-18 and, subsequently cell death [26-28]. EF has potent calmodulin-dependent adenyl cyclase activity and increases intracellular concentrations of cyclic adenosine monophosphate (cAMP) and possibly other cyclic nucleotides [29,30]. While neither toxin stimulates a robust inflammatory response, growing evidence demonstrates that each can contribute to cardiovascular dysfunction and shock (Figure?1B).
Lethal toxin
Studies in an instrumented canine model clearly demonstrated that LT produces profound cardiovascular dysfunction. Twenty-four-hour LT infusions to simulate toxin release during infection resulted in reductions in central venous pressure (CVP) and mean arterial blood pressure (MAP) that persisted for up to 72 hours [31,32]. These changes occurred in patterns similar to those in patients with B. anthracis infection and shock; and were greater in non-survivors than survivors. Hemodynamic effects such as these frequently reflect peripheral vascular dysfunction related either to endothelial barrier dysfunction with extravasation of fluid or direct dilation of arterial resistance or venous capacitance vessels. Consistent with such effects, administration of fluids and vasopressors in this LT-challenged model increased CVP, MAP and survival [32]. Inhibition of LT with a PA-directed monoclonal antibody (mAb) further increased these parameters. A growing number of in vitro studies provide a basis for these changes with LT. Table?1 briefly summarizes findings from recent studies demonstrating that LT may interfere with endothelial barrier function via several mechanisms including: disruption of endothelial cell stress kinase pathways, endothelial apoptosis, and alterations in actin fiber and cadherin function [33-36]. However, in contrast to its potential deleterious effects on endothelial barrier function, LT did not produce direct arterial dilation in an isolated aortic ring model [37].
Table 1. Selected in vitro studies implicating lethal (LT) or edema toxin (ET) in endothelial cell dysfunction
Evidence also suggests that LT depresses myocardial function. In canines, a 24-hour LT infusion caused progressive decreases in left ventricular ejection fraction (LVEF) that were blocked by PA-mAb [31,32]. Although CVP was reduced, pulmonary artery occlusion pressure was not, suggesting that decreased preload was not the primary basis for LVEF reductions. Similar to mice, more recent work in rabbits demonstrated that LT produced direct myocardial injury with dose dependent cardiac necrosis and increases in cardiac biomarkers [38,39]. In in vitro studies, LT altered intracellular cardiomyocyte-Ca++ handling and depressed cardiomyocyte function [40]. LT associated dysregulation of autophagy, ubiquitin-proteasome, and mitochondrial function may have contributed to this cardiomyocyte depression via TLR-4 [41,42]. Thus, hypotension in patients with B. anthracis may also relate to the inhibitory effects of LT on cardiac function. However, in contrast to data supporting a myocardial depressant effect of LT in studies in an isolated perfused rat heart model, LT only altered myocardial function when administered in doses substantially higher than those producing lethality in vivo[43]. Furthermore, observations in patients with B. anthracis infection, while limited, have not demonstrated consistent abnormalities in myocardial function [1-3].
In addition to its direct cardiovascular effects, LT may contribute to shock by promoting B. anthracis infection [44]. LT inactivates MAPKK pathways central to innate and adaptive immune responses and, therefore, may impair host defense and microbial clearance [22,25,45-47]. In one murine model, pretreatment with sublethal LT doses before intravenous E. coli challenge, increased blood bacterial counts and worsened survival [48]. Moreover, pretreatment of rats with sub-lethal LT doses inhibited inflammatory mediator release stimulated by lipopolysaccharide (LPS) or E. coli challenges [14]. These inhibitory effects of LT on immune responses have been proposed as a basis for the high bacterial loads noted in patients dying with B. anthracis infection [13,19,21,22].
Edema toxin
Increasing evidence indicates that ET may also be important in the pathogenesis of shock during B. anthracis infection. Twenty-four-hour ET challenge in canines produced rapid and profound reductions in CVP, MAP and systemic vascular resistance (SVR) that persisted for 72 hours [31]. Recent in vitro studies, summarized in Table?1, suggest that ET may impair endothelial barrier function by altering adherens? junction function or by inducing trans-endothelial macro-aperture tunnels [36,49,50]. However, endothelial impairment is not entirely consistent with EFs? recognized action as a potent adenyl-cyclase, since increased cellular cAMP levels may actually have protective effects on endothelial barrier function [12,51,52]. Consistent with this, ET in one study increased endothelial barrier resistance [53]. Alternatively, very high cAMP levels and their intracellular location may have paradoxical effects on endothelial integrity resulting in a net loss of barrier function [12,51,52].
Growing data suggests that EFs? potent adenyl cyclase actions may stimulate direct arterial or venous dilation. It is well known that increased intracellular cAMP levels stimulate vascular smooth muscle relaxation [54,55]. The very rapid reductions in CVP, MAP and SVR noted with ET in the canine model were consistent with a direct vasorelaxant effect rather than with disruption of endothelial barrier function and extravasation of fluid [31]. Findings from two ex vivo models further support this possibility. In an isolated perfused rat heart model, ET produced significant increases in coronary flow rate (CFR) consistent with a direct vasodilatory effect [43]. These changes with ET were associated with increases in both myocardial tissue and effluent cAMP levels. Adefovir, a nucleoside which interferes with EF adenyl-cyclase activity, inhibited these ET effects [56,57]. In a rat aortic ring model, incubation with ET increased cAMP levels and reduced arterial responsiveness to subsequent contraction with phenylephrine [37]. ET also caused relaxation in rings already pre-contracted with phenylephrine. This ability of ET to inhibit catecholamine function may provide a basis for the resistance to conventional hemodynamic support noted in patients with injectional B. anthracis infection [1-3].
Finally, ET may augment the effects of LT. In mouse, rat and canine models, nonlethal ET doses increased the lethality of LT [14,31]. ET also potentiated the inhibitory effects of LT on chemotaxis and the function of dendritic and T-cells [14]. ET?s ability to up-regulate the expression of PA receptors on macrophages and dendritic cells in vitro and to increase the rate of toxin internalization may provide a basis for synergism with LT [58]. Growing recognition of ET?s potential role in the pathogenesis of shock with B. anthracis suggests that if toxin-directed therapies are to be considered for patients, they should be directed at both LT and ET [2].
Non-toxin metalloproteases
Besides LF, B. anthracis produces other metalloproteases potentially important in the pathogenesis of vascular and nonvascular tissue injury. The delta Ames (pXO1- and pXO2-) B. anthracis strain produces metalloproteases belonging to the M4 thermolysin and M9 bacterial collagenase families [59,60]. In murine models, administration of these metalloproteases produced hemorrhagic tissue injury while treatment with selective metalloprotease-inhibitors improved survival [61,62]. B. anthracis metalloproteases Npr599 and InhA cleaved host structural and regulatory proteins important in endothelial function, including plasma ADAMTS13, von Willebrand factor (VWF) substrate FRETS-VWF73, and VWF itself [63]. InhA also stimulated plasminogen activator inhibitor (PAI-1) in mouse liver and increased blood?brain barrier permeability in both mouse brain and human brain microvasculature endothelial cells by disrupting endothelial tight junction proteins [61,62,64,65]. What the relative roles are of LF and these other metalloproteases during shock in patients with B. anthracis infections require study.
There is growing evidence that the pathogenesis of cardiovascular dysfunction and shock during B. anthracis infection is complex and likely involves both non-toxin and toxin components. Further understanding of how these components interact is essential for improving the management of severe B. anthracis infection and shock.
cAMP: Cyclic adenosine monophosphate; CFR: Coronary flow rate; CMG-2: Capillary morphogenesis gene-2; CVP: Central venous pressure; EF: Edema factor; ET: Edema toxin; HBMEC: Human brain microvascular endothelial cells; HDMEC: Human dermal microvascular endothelial cells; HMVEC-L: Human lung microvascular endothelial cells; HUVEC: Human umbilical vein endothelial cells; IL: Interleukin; LF: Lethal factor; LPS: Lipopolysaccharide; LT: Lethal toxin; LVEF: Left ventricular ejection fraction; MAPKinase: Mitogen activated protein kinase; MLC: Myosin light chain; NLRP: Nod Like Receptor Protein; NOD: Nucleotide-binding oligomerization domains; PA: Protective antigen; PAI-1: Plasminogen activator inhibitor; PRRs: Pathogen recognition receptors; ROCK-1: Rho associated kinase; SVR: Systemic vascular resistance; TEM: Trans-endothelial cell macro-aperture; TEM-8: Tumor endothelial marker-8; TLR: Toll like receptor; TNF: Tumor necrosis factor; TRAIL: TNF-related apoptosis-inducing ligand.
Competing interests
None of the authors have competing interests to report.
Authors? contributions
All authors (KER, PQ, YL, XC and PQE) have contributed to the formulation, writing and editing of this review. All authors read and approved the final manuscript.
This research was supported by the Intramural Program of the NIH, Clinical Center, Critical Care Medicine Department.
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Chung MC, Jorgensen SC, Popova TG, Bailey CL, Popov SG: Neutrophil elastase and syndecan shedding contribute to antithrombin depletion in murine anthrax.
FEMS Immunol Med Microbiol 2008, 54:309-318. PubMed Abstract | Publisher Full Text
Mukherjee DV, Tonry JH, Kim KS, Ramarao N, Popova TG, Bailey C, Popov S, Chung MC: Bacillus anthracis protease InhA increases blood?brain barrier permeability and contributes to cerebral hemorrhages.
PLoS One 2011, 6:e17921. PubMed Abstract | Publisher Full Text | PubMed Central Full Text


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Hill Country Backwoods
Refined ~ Rustic ~ Redneck-Chic
Rustic Accents, Accessories, Furnishings & Re-Purposed Treasures
Home ~ Ranch ~ Cabin ~ Barn
Custom Signs & Custom Pieces - Made to Order
We Do Rustic, Right!
Home of...
Rustic Wedding?
Barrel Wedding Card Holder
ala Rustic Style
REAL Cane Sugar Soda
A 'GO TEXAN' Product
Rustic Ranch, Cabin
At Hill Country Backwoods, we uniquely handcraft cedar, mesquite, pecan, pine, oak, barn and reclaimed woods - along with salvage, junk & flea market finds, wine barrels, metal works, leather/hides and turquoise - to create unique & one-of-a-kind pieces to add an elegant - yet rustic - feel to your home, ranch, cabin, barn or business.
'Refined Rustic' is rustic - sophisticated - by taking an old item and/or using rustic materials &/or reclaimed items, to create an entirely new rustic showpiece. The refined part involves fixing, firming, shaping, sanding, adding color, accents or details & putting on a stunning finish. Hill Country Backwoods takes takes rustic to a whole new level.
Custom pieces and signs are all made to order... & all are delivered with a Texas rustic appeal. We transform simple rustic pieces & designs into remarkable & unique rustic showpieces. It's what we do here... we're now in our sixth year... and we do it right!
Curious? Just take a browse of our Projects Gallery and you'll see what we mean by 'Refined Rustic'.
1. of or relating to the countryside; rural.
2. constructed or made in a plain and simple fashion.
NEXT Market Day
Saturday, December 5th, 2105
a customer table refinishing project
See details of this killer project in the Project Gallery (click here).
- Cedar Log Slice Table -
A unique 'Refined Rustic' creation
for a client in Llano.
Now available on order - in any dimension
A Hill Country Backwoods Original!
Hanging Wine Barrel Planter - Perfect for Springtime... and Summer... and Fall
(but maybe not winter :-).
See one 'At The Booth'
Suggested Site Links
Here are a few past pieces we've done...
Click on the large picture to view a full-page image.
Click on the large picture to view a full-page image.

subset: commoncrawl


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Baylor Bears
Photos: Morgantown madness: Baylor, West Virginia combine for 1,507 yards, but Geno Smith proves too much for Bears
Photo: Christopher Jackson/AP
Baylor's Jarred Salubi (21) is tackled by West Virginia's Darwin Cook (25) and Karl Joseph (8) during their NCAA college football game in Morgantown, W.Va., Saturday, Sept. 29, 2012. (AP Photo/Christopher Jackson)
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Easter is next Sunday, April 24, and we asked restaurants to let us know if they will be open on that day. Here are the responses.
Easter is next Sunday, April 24, and we asked restaurants to let us know if they will be open on that day. Here are the responses.
LINDSAY'S RESTAURANT in the President Abraham Lincoln Hotel, 701 E. Adams St., will have an Easter brunch in the Presidential Ballroom from 11 a.m. to 3 p.m.
There will be a carving station with prime rib and ham, a breakfast station with made-to-order omelets, a bakery display, salad station, pasta station, smoked salmon, peel-and-eat shrimp, dessert buffet and chocolate fountain.
Cost: $26.99 for adults, $12 for children 6-12 and free for ages 5 and under. Reservations, secured with a credit card, are required; call 321-2422.
LIME STREET CAFE, 951 S. Durkin Drive, will have an Easter brunch from 10:30 a.m. to 2 p.m. Among the offerings are leg of lamb, ham, fish, chicken Hunter, fresh salads and fruit, smoked salmon and bagels, breakfast items (scrambled eggs, bacon, sausage, muffins, filled crepes), red potatoes and other vegetables and a full dessert table.
Make reservations by calling 793-1905.
INDIGO, 3013 Lindbergh Blvd., will be open from 5 to 10 p.m. on Easter. The full menu will be available. Two private dining rooms are available for reservations, as well. Phone: 726-3487. Website: www.indigocuisine.com.
CHESAPEAKE SEAFOOD HOUSE, 3045 Clear Lake Ave., will serve an Easter buffet from 11 a.m. to 6 p.m.
It will feature roast turkey and dressing, ham, roast pork, seafood au gratin, broiled fish, mashed potatoes and gravy, a variety of vegetables, egg noodles, salads, rolls and desserts.
The cost is $14.99 for adults and half price for kids under 10. Call 522-5220 for reservations. Website: www.chesapeakeseafoodhouse.com.
GOLDEN CORRAL, in front of Walmart on South Sixth Street, will open for breakfast at 7:30 a.m. on Easter; dinner will begin at 11 a.m. Dinner will include ham, smoked beef brisket, pork loin and the traditional buffet with sirloin steak, salad bar, bakery bar, dessert bar and more.
The dinner price, including beverage, is $12.99 for adults, $11.99 for seniors, $4.99 for kids 9-12, $3.99 for kids 4-8 and free for ages 3 and under. Phone: 585-6830.
SECRET RECIPES, 319 N. Main St. in Chatham, is selling an Easter feast-to-go that feeds six to eight people. It has ham, au gratin potatoes, green bean casserole, rolls and butter and apple-nut caramel pie for $79.95.
Place an order by Thursday by calling 483-9500. Specify hot or cold. Pick up Saturday before 7 p.m.
LE PEEP, 3232 Ginger Creek Drive, will be open from 7 a.m. to 2:30 p.m. on Easter. Breakfast and lunch is served all day. Phone: 679-1752.
MARIAH'S RESTAURANT, 3317 Robbins Road, will have an Easter buffet from 10 a.m. to 3 p.m. The full menu will be available from 3 p.m. to 9 p.m.
Page 2 of 3 - On the buffet: beef and ham station, salmon, tilapia, fried chicken, mashed potatoes and gravy, sweet potato casserole, mushroom ravioli, shrimp fettuccine Alfredo, veal cannelloni, mostaccioli, rolls, vegetables, salads, desserts and candy-filled Easter eggs for the kids. Bloody Marys and mimosas will be $4.
Cost: $19.95 for adults, $9.95 for children 5-10 and free for ages 4 and under. Call 793-1900 to make a reservation. Walk-ins welcome.
The LINCOLN DEPOT train station, 101 N. Chicago St. in Lincoln, will present an Easter buffet from 11 a.m. to 2 p.m.
Menu items include roast pork, roast beef and gravy, ham, baked turkey breast, grilled chicken, linguine with butter-garlic sauce and shrimp scampi, fettuccine Alfredo and chicken, pasta with meat sauce, mini corn dogs, vegetables, potatoes, salads, soups and a variety of desserts. Coffee and tea are included.
Price: $18 for adults, $16 for seniors 60+, $7 for kids 4-12 and free for ages 3 and under. Website: www.mccartysdepot.com (click on Depot News). Phone: 735-3311.
AMBER JACK ALEHOUSE, 3150 Chatham Road, will have a spring brunch beginning at 10 a.m. The last seating is 2 p.m.
Among the menu items are prime rib, barbecued baby back ribs, grilled salmon with fettuccini Alfredo, fried chicken, grilled chicken breast with wild rice, beef fillet tips in mushroom sauce, mostaccioli, ham steak, mashed potatoes and gravy, au gratin potatoes, breakfast items (scrambled eggs, quiche Lorraine, bacon, sausage, French toast sticks), salad station with peel-and-eat shrimp and many desserts. Coffee, tea, soft drinks and juices are included.
Price: $19.95 for adults and $8.95 for children 10 and under. Reservations are accepted but not mandatory; call 787-5222. Full menu at www.amberjackalehouse.com.
An Easter buffet at MYRA'S HOMESTYLE RESTAURANT, from 10 a.m. to 3 p.m., will feature ham, turkey, roast chicken, baked fish, roast beef, corn dogs, casseroles, salads and desserts.
Also, owner George Rogers will perform a tribute to Elvis at 6 and 7:30 p.m. Friday and Saturday.
Myra's is at the Auburn-Pawnee exit on I-55. Phone: 628-9010.
STONEBAKE PIZZA CO. at Fifth and Douglas streets in Petersburg will have an Easter brunch from 11 a.m. to 2 p.m. The menu includes roast beef and ham, breakfast entrees, fresh fruit and pastries, pasta, vegetables, side dishes, soup and salad bar, desserts and coffee, tea or soda.
The cost is $14.95 for adults, $5.95 for kids 4-10 and free for ages 3 and under. Reservations are recommended; call 632-2461. The full menu will be available after 4 p.m.
CENTRUM CAFE, 1370 Toronto Road, is selling cream pies (banana, coconut, chocolate, Key lime) for Easter. Order in advance by calling 414-3197.
* Is your restaurant serving Mother's Day dinner on Sunday, May 8? If so, please send the details (including holiday menu items, prices, restaurant name, address, phone and hours) to the A La Carte column. The submission deadline is 5 p.m. Wednesday, April 27. The list will be published Sunday, May 1.
Page 3 of 3 - The A La Carte column is written by Kathryn Rem, 788-1520. It highlights restaurant openings, closings, renovations and relocations, as well as personnel changes and business news. Menu items are listed for new restaurants. Send items to A La Carte, The State Journal-Register, One Copley Plaza, Springfield, IL 62701; fax to 788-1551; or e-mail firstname.lastname@example.com. The deadline for Sunday's column is 5 p.m. Wednesday. Please include your name and daytime phone number.
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Tod's elaborates on brand values with Italy-wide guide to "living well"November 13, 2015
Italian fashion label Tod's is positioning itself as an expert authority on its home country with the release of a guidebook.
Italian fashion label Tod's is positioning itself as an expert authority on its home country with the release of a guidebook.
French leather goods house Hermès is celebrating the art of exploration and urban meandering with an exhibit at Saatchi Gallery in London.
Following the example of named handbag collections, beauty marketers have begun to look inward when naming cosmetics to script narratives that are reflective of their brands and can be applied to a consumer's own life.
Department store Bergdorf Goodman is helping its consumers plan for their trips to warmer locales with its resort magalog.
French couture house Christian Dior is highlighting its golden gift selection with a social video that takes consumers inside an imagined automatous factory.
The Financial Times' lifestyle supplement "How To Spend It" is celebrating the 20th anniversary of its launch with a fundraising issue Nov. 29.
Fashion brand Maison Martin Margiela has introduced new two fragrances to round out its olfactory narrative collection, Replica.
British online retailer Net-A-Porter is offering a seven-day body reboot program for consumers to learn a new work-out and recipe each day while viewing clothing options on the Web site.
U.S. label Michael Kors is celebrating the launch of the new publication by Claiborne Swanson Frank, "Young Hollywood," a book that features a foreword by the brand's namesake designer.
French apparel brand Christian Dior is assuring consumers that its dedication to craftsmanship extends beyond its fashions and handbags.


text: > View Product Details Please select the size of the product. Please enter valid quantity. RD Style ultramarine jersey knit asymmetrical peplum t-shirt overview details Retail: $58.00 Reduced: $14.97 40% Off : $8.98 color : We're sorry. This style is sold out. Ultramarine With cute and contemporary looks like this asymmetrical peplum t-shirt, it's easy to fall for the RD Style. Color: Ultramarine Lightweight stretch jersey knit Crewneck Shot sleeve Asymmetrical peplum hem Contemporary fit 100% Rayon; Machine Wash; Imported; style#323386402


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There's a lot of unnecessary mystique around branding touted by hipper-than-thou creatives in funny glasses.
It's really very simple. Branding is about understanding who you are in relation to the world.
When everyone on your team has a shared understanding of your identity, great things are possible.
When you have a story to tell, then what? Do you run out and make a video? Not yet. Your storytelling should be as strategic as everything else you do. A scattershot approach won't do.
We use a four-step process to help you clarify your goal, understand your audience, craft your message, and choose the most appropriate means of expressing it.
Great content does three things. It creates an emotional connection with your audience. It makes a clear, logical argument. And it contains a call to action, a way for your audience to engage.
Whether it's copy, video, slides, animation, or an entirely new web site, our award-winning team will create whatever you need to cut through the noise and have your voice be heard.
The Chorus Foundation wants to ensure that the transition to a low-carbon economy benefits working people and local communities.
We've been working with the foundation and their grantees to craft a messaging strategy that inspires other funders to invest in grassroots approaches to addressing climate change. It's a soup-to-nuts project in which we are providing strategy, visual identity, website development, copywriting, video production services.
The creators of the first fair trade coffee label, Solidaridad continues to innovate as they work with producers and companies on the equitable sourcing of coffee, soy, palm oil, cotton, sugarcane, and other commodities.
Solidaridad North America has hired Landry Communications to help them create and implement a communications plan to raise their profile among key audiences. In addition to developing strategy, we will produce videos and other tools that tell their story to potential donors, business partners, and others.
American Farmland Trust
Civil Liberty and Public Policy (CLPP)
Pulse Canada
Reos Partners
Rippel Foundation
Solidago Foundation
Stonyfield Farm
The Sustainable Food Lab
Waters Foundation
These are amazing times. So many people are finding incredible, courageous ways to make things better on our planet — but they don't always know how to explain their work in ways that can inform and inspire others. That's where we come in.
Chris Landry learned how to tell effective stories during the two decades he spent in the non-profit world, most recently as Director of Development & Communications at the Sustainable Food Lab (and, before that, at The Food Bank of Western Massachusetts).
Clients tell Chris that what he delivers is clarity. Chris helps them discover and articulate their one, core story — and that makes them better in everything they do.
Because every client needs something a little different, and because nobody wants to pay for high agency overhead, we run a virtual agency. Depending on your needs, we put together custom teams of smart people to help you achieve your specific goals. From brand identity to video, fundraising to online strategy, we have the team to deliver world-class work at a fair price.


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11 posts tagged with support and work.
Displaying 1 through 11 of 11. Subscribe:
Support my wife with her new career, that hasn't paid yet.
Marriage / Employment filter: My wife is finally incredibly happy in her job (a new career), but it hasn't paid a check for 6 months. I want to be supportive, but all I see is her working her ass off and not getting paid. What do we need to talk about / to weigh at the 1 year mark when we assess her getting a job with a salary? (see within for a very long story) [more inside]
What can I do (or not do) for a friend with headaches?
Sufferers of headaches - what do you like/dislike when you're in the thick of it? A friend of mine has recurring headaches of unknown cause. They are on medication so the pain is manageable, but they live alone and often have to go to work (9-5 office job) in the middle of an episode. They live far away so I can't offer to pick up groceries for them or anything like that, but I can and do IM them words of comfort. What else am I missing?
Place on the internet to commiserate and get support about crappy jobs.
As the title says, I was just wondering if there's some place on the internet where people unhappy with their jobs can congregate, rant, commiserate, get advice, get support, support others, feel accepted and not alone, etc. It should preferably be an active place, not a forum that gets a single new post every few days or weeks. I know it's not healthy to just rage and complain all the time about a situation. Sometimes, however, you've just got to get something off your chest and know that someone is listening. And girlfriends and parents can only take so much of this, productive or not, because they're so much closer to you. This is more about just meeting people that are experiencing similar difficulties in life and having an active, understanding support group. [more inside]
How can I be a good straight ally at work?
How can I show my support for a new co-worker in my company's homophobic environment? [more inside]
Here, let me help you with that
How do I make a long project a little more fun for the BF? [more inside]
If I give in, I'm giving in to all the cute, fuzzy bunnies in the world.
All of the places I trust to provide comfort and security, in any form, are imploding. I've already been existing in coping mode; what can I do now (particularly day-to-day)? [more inside]
How do I get hired as a legal documentation specialist?
I want to get a job as a legal documentation specialist (word processor). I have no prior work experience in law firms. What's the work like, and how do I get hired? [more inside]
worst day at work ever or what?
My coworker came to work and shot himself today. I was the only person to talk to him and was one of the first people to reach him after he did it. I'm planning on speaking with the grief counselors they're bringing in tomorrow. But I'm wondering if there are any resources I should know about for people in a situation like mine, specifically: witnesses of the suicide of a coworker or friend. In case the details are relevant: they are below. [more inside]
best practices for supporting online user communities?
Does anyone have any information about best practices & strategies for online community support and community development? [more inside]
How can I balance the various needs of support group members?
I would like to learn to better facilitate a stress support group. [more inside]
How to cope with the firing of a friend and coworker?
A friend was just fired from my department for somewhat vague reasons. I've heard the story from my friend, and the managers have yet to say anything to the rest of us. As far as I can tell, my friend did nothing scandalous, illegal, or that violated my employer's policies. My friend is also not lazy. Everyone in the department is confused, and our morale is clearly shot. How do I support my friend and my coworkers? How can I/we move on enough to get day-to-day work done? [more inside]
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What is Address Search?
Spokeo reverse address search helps people connect with their neighbors and find people by address. Search your neighborhood today to find out current residents, past residents, and family information. Find out who lives on Quiet Waters Rd today.
Other Spellings
Quiet Waters Rd is also spelled Quiet Waters Road.
Belmont, NC
Time Zone & Current Time
Belmont, NC lies within the Eastern Standard Time (or EST). The current time in Eastern Standard Time is 12:23 AM on 11/28/2015.
Belmont, NC
Top Streets
10th St, 11th St, 12th St, 13th St, 1st St, 2nd Ave, 2nd St, 3rd St, 5th Street Ext, and 6th St
Belmont, NC
Population Demographics
Household Income
Home Value
37 years old
51% female
Local Ethnicity
Ethnicity Ratio
About Belmont, NC
Belmont is a city in Gaston County, North Carolina, United States, located about 15 mi west of uptown Charlotte, North Carolina. The population was 8,705 at the 2000 census. Once known as Garibaldi, the city named in honor of August Belmont, a prominent New York banker. Belmont is home to Belmont Abbey College. (more on Wikipedia)


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TORONTO, Nov. 21, 2012 /CNW/ - Unilever Canada has been named one of Greater Toronto's Top Employers 2013 by the editors of Canada's Top 100 Employers. The annual competition identifies companies that lead their industries in offering exceptional places to work. Unilever was one of five consumer packaged goods companies to earn the top rating. "Unilever is proud to be named one of Greater Toronto's Best Employers. It is a great external recognition of our efforts and commitment to create an environment where all our employees can excel," said John Le Boutillier, President and CEO at Unilever Canada. " We aim to attract top talent across a diverse population by offering a competitive rewards package, excellent training programs and career progression, and a commitment to Sustainable Living." Unilever was chosen for its excellence in eight key areas that were examined for the 2013 survey: Physical Workplace; Work Atmosphere & Social; Health, Financial and Family Benefits; Vacation and Time Off; Employee Communications; Performance Management; Training and Skills Development; and Community Involvement. A full summary of the ranking can be found at www.canadastop100.com/toronto/. About UnileverCanada Inc. Unilever is one of the world's leading suppliers of fast moving consumer goods with operations in over 100 countries and sales in 190. Working to create a better future every day, we help people feel good, look good and get more out of life with brands and services that are good for them and good for others. In Canada, our portfolio includes brand icons such as: Axe®, Becel®, Ben & Jerry's®, Breyers®, Clear®, Degree®, Dove® personal care products, Hellmann's®, Klondike®, Knorr®, Lipton®, Magnum®, Nexxus®, Popsicle®, Q-Tips®, Simple®, Skippy®, St. Ives®, TRESemmé®, and Vaseline®. All of the preceding brand names are owned or used under license by Unilever Canada Inc. Our ambition is to double the size of our business, while reducing our overall environmental impact (including sourcing, consumer use and disposal). We are also committed to doing what we can to improve health, nutrition and hygiene, with goals to help more than a billion people take action to improve their health and well-being, as well as to source all our agricultural raw materials sustainably by 2020. Supporting our three big goals are more than 50 time-based targets in the Unilever Sustainable Living Plan. Unilever employs more than 1,600 people across Canada. For more information, visit www.unilever.ca. Media Contact Katharine Williams Unilever (416) 529-0645 firstname.lastname@example.com SOURCE: Unilever Canada Inc. To view this news release in HTML formatting, please use the following URL: http://www.newswire.ca/en/releases/archive/November2012/21/c2354.html CO: Unilever Canada Inc. ST: Ontario NI: MTC HOU ENT -0- Nov/21/2012 19:05 GMT
Unilever Recognized as a Top Employer in Greater Toronto
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Metal Mulisha Louder Black Flexfit Hat
Item # 194497
Take An Additional 50% Off
Stash Points: 0
What is this?This is the number of points you get in The Zumiez Stash for purchasing this item. Stash points are redeemable for exclusive rewards only available to Zumiez Stash members. To redeem your points check out the rewards catalog on thestash.zumiez.com.
Rev up the engine and let your exhaust blast with the Louder Flexfit hat in black from Metal Mulisha.
|More Details


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Nancy Jo Sales
Revolving Door (0)
Sightings (4)
Robert Pattinson's LA-to-New-Orleans Road Trip - Posted March 1, 2011
There's a cool Los Angeles flavored anecdote in the ... [FishbowlLA]
Morales Melodrama: Nancy Jo Sales on her Spiritual Marriage - Posted December 30, 2007
The story of Theresa Duncan and Jeremy Blake's tragic deaths really should become an opera, not a sad little documentary, not a poorly-lit cinema-stylo indie movie. Everyone involved is so dramatic. Famed writer Nancy Jo Sales, aut... [FishbowlLA]
Sundown on Sunset: Lonely Streets - Posted December 7, 2007
The long awaited Vanity Fair piece on Theresa Duncan and Jeremy Blake comes out in the January issue, by Nancy Jo Sales. Fun fact: Sales was married t... [FishbowlLA]
Potty-Mouth Padma in Vanity Fair - Posted November 9, 2007
Nancy Jo Sales has the Padma Lakshmi story in VF, but overstates things a wee bit: How amazing was it that she, the daughter of a single mother who fled India to escape the stigma of divorce, was poised to beco... [FishbowlLA]


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HP 2000-2d22D
X does not power on
After a few months of usage my laptop computer does not power on.At first i thought it was an uncharged computer but it sems that is not the case. After being left to charge for 30 minutes and longer it does not power on. I need help cause i have a lot of work on this computer. Is there any way to help me? I would like to keep on using this computer.
Re: HP 2000-2d22D
X does not power on
Hi Gael1234,
Thank you for visiting the HP Support Forums and Welcome. I have read your thread on your HP 2000-2d22DX Notebook and getting a blank or black screen on startup. Try performing a hard reset. When performing a hard reset please note remove any and all USB devices, and remove memory cards from the card reader slot. Disconnect all non-essential devices. If that does not help try to turn on the computer you start to press F11 repeatedly till the menu opens. Here is a document on computer won't start.
Hope this is helpful.
Please click "Accept as Solution " if you feel my post solved your issue, it will help others find the solution.
Click the "Kudos, Thumbs Up" on the bottom to say "Thanks" for helping.
I work on behalf of HP
Re: HP 2000-2d22D
X does not power on
Thank you Mrstenter for your suggestion but unfortunately it has yeilded no results. My computer still does not turn on. Is there another solution? Will i have to send it in to be fixed?


text:
failure rate at 54.2 percent, we were thinking that was a bit steep of a number, possibly bumped up a few digits from some possible sampling errors. So when we were gearing up to read Microsoft's statement responding to the data, we fully expected some harsh rebuttal of the number. Turns out we got disappointed. A spokesperson for Redmond pointed to its superior entertainment value, its "best warranty in the industry" and its "constantly improving design, manufacture, and performance." At no point is there a dispute or even direct reference to the findings, which is really something that could've helped public perception on a nagging issue. How about taking a page from Fujifilm, eh Microsoft?
Microsoft Xbox 360
Buy from $220
- Key specs
- Prices
- Discussions
- Game format Optical disc, Downloadable
- Online features Multiplayer, Voice chat, Video chat, Store
- Drive capacity 4 GB
- Controller type Wired, Wireless
- Motion controls Camera / optical
- Video outputs Component, HDMI (v1.4)
- Weight 10.9 lb
- Released 2010-08-03
Microsoft Xbox One


text:
- Jessa Duggar shares a rare photo of her brother Josh Duggar's daughter Meredith - US Weekly
- Michael Lohan's estranged wife Kate Major is detained by cops at an airport - TMZ
- Is there something between Ben Affleck and Halle Berry? - Gossip Cop
- The Hunger Games author Suzanne Collins says goodbye to the popular series after the final movie is released - Just Jared Jr
- What happened backstage with Kylie Jenner at The Ellen Show? - Radar
- Bryan Cranston tears up over a Breaking Bad memory - Huffington Post
- Leonardo DiCaprio's Oscar race heats up - Lainey Gossip
- The Captain America: Civil War movie may be better than the comic book - The Hollywood Reporter
09 January 2012 at 10:05 AM
Hugh Jackman: Returning to Broadway in 'Houdini'!
About this photo set: Hugh Jackman and his daughter Ava play a friendly game of tag as they head to her school on Friday morning (January 6) in New York City. The 43-year-old Aussie… Read More Here
Photo #: 2615550
Posted to Broadway, Celebrity Babies, Deborra Lee Furness, Hugh Jackman


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Leading up to the release of her still-untitled forthcoming album, [artist id="1236911″]Beyoncé[/artist] has been working the charity circuit. After hooking up with first lady Michelle Obama for the "Move Your Body" campaign, the superstar surprised students at New York City's PS 161: Pedro Albizu Campos middle school in Harlem on Tuesday to help spread the word about the importance of fitness.
It's not the only charity-based news that Queen B is making these days. Beyoncé has put her own signature diva spin on the classic track "God Bless the USA" and the patriotic track is available now on iTunes, with proceeds going toward the New York Police & Fire Widows' & Children's Benefit Fund. According to a press release, the organization is "a volunteer based not for profit dedicated to helping the families of fallen New York firefighters, police officers, EMS and Port Authority police killed in the line of duty." The singer debuted the song on CNN's "Piers Morgan" on Thursday night.
"I cannot think about anything more appropriate to do to help these families," she said in a statement about the tune, which plays showcases the performer's strong singing abilities. "Almost 10 years [after 9/11], it is still so painful for all Americans, especially those who lost loved ones.
"We were all affected by the tragedies of 9/11 and continue to keep the families who lost loved ones close to our hearts," the singer continued. "Thank you Piers Morgan and CNN for helping to get the message out to everyone about this."
"On behalf of New York Police & Fire Widows' & Children's Benefit Fund's Board of Directors and the families of our fallen heroes, we are truly grateful for Beyoncé's choice to support our charity and 'answer the call,' " Stephen J. Dannhauser, chairman of the New York Police & Fire Widows' & Children's Benefit Fund, said.


text: These cabins are clean, great and feel very cosy. The wooden frames with the exposed stone work create a nice earthy, rustic feel. Although we weren't there at ski season, I can imagine it being the perfect chalet choice. The owners gave us useful orientation advice and were always very helpful. The only thing I'd change is to have a... More


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im glad i found out about this site it's becoming a great tool in helping me raise my 9.3month old son looking forward to great tips and advice for a single father raising this most precious gift.
dad doing it alone
Comments (7)
How old is your son? And congrats, Dad!
other to Jade (2) [8.28.09]
Congratulations and welcome. If you have any questions don't hestitate. I'm a 1st time mommy but I'm picking up on it pretty quick as I'm sure you are as well.
Baby Julia Marie has finally arrived on 2/24/2010 @ 12:30!
8lbs,� 20 3/4" long
Married since 8/27/2003�together since 1/6/1995
Congratulations DAD! I'm a first time mom. I have such a supportive dad helping me and I must say you're real special taking care of your child.
Mother to Xola K born 21 01 2010
Married to my best friend Jared 8/14/04
Riley Miguel "Monkey" Born 9/15/09!!
Furbabies Delilah, Oscar, & Xerox
-FTM to my DD.
Visit My Shop! �blushingbaby.etsy.com
Welcome !!
Im a first time / stay at home mommy !
l0ViNG MY LiTTLE MAN [PR0UD M0MMY] 6[25]10
Jessica &+ Eric 3l10l09
All because two people fell in lOVE -
Proud Mommy 6l25l10 * he's my world *
Hi DAD, and welcome, i am a sahm to 4 and one on the way... any questions ask away :))
Proudly breastfeeding for 7 yrs now :)


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We heartily applaud any effort to green your diet. But beware: looks can be misleading.
While organic is much better for the environment since it excludes pesticides and many types of preservatives and fillers, not all organic food is created equal. Likewise, some things that may be healthy for you are not healthy for the environment.
Here are eight types of foods marketing themselves as eco-friendly that you should reconsider.
We know there is a lot of debate out there about whether eating meat can ever be sustainable. But setting that aside for a moment, lets consider organic meat and dairy. You would think organic would be the best option out there for meat and milk, right? Unfortunately, that isn't always the case. Often organic meat and milk producers crowd their cattle into feed lots after only a short time on grass. The grain is organic, but the sentiment isn't. The result is concentrated waste and pollution. Fully grass-fed cattle are much better for the environment. Luckily the FDA released new, stricter rules in February governing the amount of pasture milk cows must have access to. The new rules still allow for finishing organic cows on grain, however. Look for "100% grass-fed" meat, or pasture-finished beef, goat, turkey, and other meats at your local farmers market. Even better, ask the farmer at the market about how the animal was raised.
There is just something wrong with the idea of peeling back cellophane from an organic dinner. It seems to miss the point, doesn't it? There are a few reasons why organic TV dinners are not good for the planet. First, there is the packaging: plastic upon plastic, with a box outside, just for one meal! Second, even organic frozen TV dinners make use of loopholes in the USDA certification system to throw in preservatives and other unsavory fillers. As Michael Pollan famously pointed out, organic TV dinners can run to 31 ingredients, including natural chicken flavor, high-oleic safflower oil, guar and xanthan gum, soy lecithin, carrageenan, and "natural flavor." Finally, TV dinners had to travel a long way to get to your supermarket, and they did so in an energy-intense refrigerated truck, which is just one more reason to resist the siren song of the microwave dinner.
It does seem oh-so-green to wander the aisles of your health foods stores, popping healthy guava, mini bananas, lychee berries, and other tantalizing fruits in your shopping cart while the snow swirls outside, doesn't it? And while these fruits may have "USDA Organic" emblazoned in green on their little sticker, they may be less green than you think. That is, unless you're reading this from California or Florida. It took a lot of energy to ship you those exotic fruits, tender asparagus shoots, and even mundane strawberries if you're picking them up in December. May we suggest some creamy mashed potatoes or olive-oil sautéed squash instead?
Never has a food word been so used and abused. You would be forgiven for thinking that "natural" means, well, natural: no preservatives, nature made. Unfortunately, because the word natural is not regulated, it can be slapped on everything from lemonade with high fructose corn syrup, to flavors that were dreamed up in a lab. If a label says "all-natural," your warning bells should go off.
Eat local! It's a great mantra to keep in mind. But there is one area in which eating local falls short: fish. For example, even if you are having dinner somewhere on the Atlantic coast, the native home of Atlantic cod, you'll want to avoid this catch. According to Monterey Bay's Seafood Watch, this fish has been so exploited in the Atlantic region it is listed as endangered or threatened. For once, the greener option is to get your fish from far away. Alaska cod is a better choice in this case. And check out a more detailed guide on sustainable fish here.
When organic cookies or granola bars are packaged up in single servings, it means you'll be throwing away a lot of non-recyclable materials. Buying in bulk is always the best idea, and will save you money too.
Hahahahahahah, oh, whoo! Hold on, we need to catch our breath. The idea that having "50% less plastic" in a water bottle, or a cap that is a centimeter shorter, is good for the environment is just silly. It's still a plastic water bottle that has a good chance of ending up in a landfill or floating around in the ocean, and that is not funny. If you have no other choice, less plastic is better, but a water bottle with almost no plastic, that can be used over and over, is best.
Your heart is in the right place when you buy soy products, especially if you're doing it to be kind to the environment, or to baby cows and lambs. Go you! However, when soy gets pumped full of additives, or used as a filler (hello soy lecithin) in other high processed products, it loses that green halo. An estimated 19% of US energy is used in the production and supply of food. You can cut down on that by eating pure, whole foods that haven't been molded to look like hot dogs or lunch meat. Try throwing some seitan or just plain tofu on the grill or in your stir fry. Yum!
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1583 Views 2 Replies Latest reply: May 1, 2012 9:35 AM by MichelA
Bob Timmons Apr 9, 2012 8:32 PM
Re: No airport card installed! in response to Foto7
Unfortunately, there are 2 main reasons for this message:
1) The AirPort card has failed and will need to be replaced
2) The AirPort card is not making good electrical contact in the socket where it is installed
In either case, this is a job for a service shop, so you should take it to an Apple Store....if you have one in your area....or contact Apple Support directly for options and instructions.
MichelA May 1, 2012 9:35 AM
Re: No airport card installed! in response to Bob Timmons
What did it for me after everything else (SMC, PRAM reset) failed was to reinstall my system using the original disks that came with my computer. Back up your important stuff first, of course.


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2010 TMT Global Security Study: Key Findings - Bounce Back
At the time of the 2009 Global Security Study, the economy was in the deepest depths of a global recession and organizations were reviewing and cutting costs everywhere they could-including security. The damage done by last year's budget cuts is reflected this year in respondents' responses: 57 percent of organizations polled believe they are falling behind or still catching up in dealing with security threats. Only one-third of the respondents believe they are "On plan"-compared with 60 percent in the 2009 study. This year's study shows a slight increase in security investment in anticipation of an economic recovery. This year's study shows a slight increase in security investment in anticipation of an economic recovery. After more than a year of restricted spending and postponed projects, significant security and infrastructure upgrades are finally underway. Many technology, media and telecommunications businesses were among the first to be affected by the economic crisis and are now among the first to benefit as economies recover. Technology organizations in particular are at the forefront of the recovery. The study shows a noteworthy increase in information security budgets over the past 12 months. Ten percent of respondents increased their budget by more than 10 percent. Thirty-six percent increased their budget by up to 10 percent. In light of the global recession - and still fragile recovery- 38 percent of respondents have established metrics aligned with business value to measure the effectiveness of their security investments, while another 24 percent are moving in that direction. These figures show that technology, media and telecommunications organizations are trying to spend their information security budgets wisely. They want to obtain high security levels at a reasonable price and are positioning themselves for an optimistic (but still uncertain) future.


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Nemesis/Tomb Raider/Baird
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May 28 2013, 06:34 PM
Greg Cox
Location: Oxford, PA
Re: Nemesis/Tomb Raider/Baird
cardinal biggles wrote:
If you think about it, though, that was kind of always the problem with the TNG movies. "All Good Things..." was such an excellent finale for TNG, both as a general summing up and also how they made it dovetail with Q's trial from "Farpoint." Even though the ending of AGT makes it clear that the crew's mission continues on, it was a great ending, and what more needed to be said? As a result, all four TNG movies had this sort of superfluous, tacked-on feeling. Yeah, the shift to movies gave them more money to play with for visual effects, sets, and extended location shoots, but I'd argue that as far as story and character go, none of them were markedly better than what we got from seven years of TV.
Hmm. You may be onto something here. TOS fans were (famously) left wanting more when the show was cancelled prematurely, so they were ecstatic when TOS (finally!) returned to the screen. But TNG had reached a perfectly satisfying conclusion--and was barely gone long enough to be missed before the TNG movies started rolling out.
Maybe that's why they (arguably) didn't quite catch on like the TOS movies did.
Greg Cox
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- News Releases
- Synovus Appoints Santosh Kokate as Chief Technology Officer and Amyn Tajani as Chief Digital Officer
- Synovus Family Asset Management Named One of Bloomberg Markets Magazine's
- Synovus to Present at the Bank of America Merrill Lynch Banking and Financial Services Conference
- Synovus Announces Earnings for Third Quarter 2015
- Synovus Announces 2015 Jack Parker Scholarships
- Synovus Announces Earnings for 2Q 2015
- American Banker/Reputation Institute Names Synovus One of America's Most Reputable Banks
- Synovus Announces Earnings for the Fourth Quarter
Synovus also announced that four incumbent directors –
"Assuming their election at our upcoming Annual Meeting of Shareholders, we look forward to welcoming Joe and Cathy to our Board," said
"I deeply appreciate the service of our retiring directors and, at the same time, I am excited about working with Joe and Cathy," said Kessel D. Stelling, President and CEO of Synovus. "Their impressive business and industry experience will further diversify our Board and provide additional expertise and oversight as we continue to execute our long-term strategy. Our priorities continue to be returning Synovus to profitability and pursuing growth opportunities throughout our footprint."
These changes will reduce the size of Synovus' Board and supplement its financial and risk expertise, consistent with best practices of corporate governance.
Mr. Prochaska, 60, served as Executive Vice President and Chief Accounting Officer of MetLife, Inc. from 2003 to 2009. From 1992 to 2003, Mr. Prochaska served in various executive leadership positions at Aon Corporation, including Senior Vice President and Controller, Executive Vice President and Chief Financial Officer of Aon Group, Inc. and President of Aon's Financial Services Group. Mr. Prochaska currently serves on the boards of directors of Baird & Warner, Inc. and Xylogenics, Inc. and is a member of the American Institute of Certified Public Accountants and the National Association of Corporate Directors and Financial Executive Institute.
Ms. Allen, 64, is Chairman and Chief Executive Officer of The
About Synovus
Synovus is a financial services company with more than $30 billion in assets based in
Forward-Looking Statements
These forward-looking statements are based upon information presently known to Synovus' management and are inherently subjective, uncertain and subject to change due to any number of risks and uncertainties, including, without limitation, the risks and other factors set forth in Synovus' filings with the Securities and Exchange Commission, including its Annual Report on Form 10-K/A for the year ended


text: Teachers are sometimes criticized for not using the technology available to them enough in the classroom. That's not the case for Cedar Grove-Belgium High School science teacher Tina Stauber, who is teaching a senior advanced chemistry class from her Sheboygan home while she recuperates from surgery. She teaches the college chemistry course for Lakeland Technical College in Cleveland. Stauber was concerned her students, although among the brightest in the school, would be at a disadvantage if they missed several weeks of instruction and had to rely solely on their independent study skills. She turned to the school's technology guru Brad Navis, who set up a video conference program that allows her to conduct lectures from her home during class and connect with students at home. All the students have access to Web cams on laptops or home computers in addition to classroom computers. In the chemistry classroom, Stauber can be seen on a screen set near her empty desk. Substitute teacher Patrick Hollett, who is teaching Stauber's other science classes, is usually in the classroom. Although Hollett has a chemistry degree, he doesn't have a master's degree, which is required for a college-level course. "It's working OK, but it's a little more difficult than I thought," Stauber said of the arrangement. "They can see me, but I can't see them. I can only see the student in front of the computer, so I can't gauge their responses. When I'm teaching, I can tell by their faces if they're getting it or not. Some things are difficult to explain without knowing what they're comprehending." Students who have questions funnel them through a student moderator who poses the questions to Stauber. That's usually Alex Ford or Jim Gallagher, who are familiar with the software. Stauber records lectures and posts reading assignments and PowerPoint explanations that students can access anytime. She gave a chapter test Monday. They didn't do as well as they usually do, some students said. "It was a little harder because it required more independent study," said Alex Isken, who is salutatorian of his class. "If you followed the lectures she recorded for us, her e-mails and PowerPoints, I don't think it was that bad. I think it's been working very well." Mary Asma, who is the class valedictorian, said she's happy her teacher is well enough to give classroom lectures again. "The first couple of weeks, we weren't able to video conference, and that was difficult," Asma said. "It's a little more time consuming to ask questions, but we're definitely able to get our points across. It's good to be able to get instruction from her again. "It was a little difficult adjusting to having her gone, but it's really cool now that we can use technology to connect with her." The students, who are all seniors, can pay tuition to Lakeland to receive college credit in addition to earning high school credit. Students may also take an advanced-placement test at the end of the school year to receive chemistry credits. Isken, a student representative on the School Board, told the board about the video arrangement in January. "We did a practice run before she left and it went pretty good," Isken told the board. "I thought it was neat that she's taking the time to help us." School Board President Jim Lautenschlaeger agreed. "It's really great that you're using technology to do this, and hopefully we can learn from your experience and use it in other areas," he said. Social Studies teacher Dave Claerbaut noted, "This isn't something she needs to do. It's something she wants to do because she loves her kids." Stauber said she hopes to return to the classroom in person in late February.


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Appointments & Offices
Check insurance plans, locations and make an appointment
Is Stephen Perkey accepting new patients?
If you are a new patient, please check with Stephen Perkey before scheduling an appointment.
What insurance does he accept?*
- Anthem
- Anthem Blue Cross Blue Shield
- Blue Cross Blue Shield
- Blue Cross Blue Shield of Illinois
- First Health (Coventry Health Care)
- MultiPlan
- UnitedHealthCare
Office Locations
- Kings Dghtrs Brlngtn Fam Cr Ctr
- 384 County Road 120 S
- South Point, OH 45680
- (740) 894-2080 (Office)


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night were dark, within was so great brightness of light without candles that it was marvel; and it seemed him the sun shone there. With that he issueth forth and betaketh him to the way he had abandoned, and prayeth God grant he may find Lancelot of the Lake.'
W.W. Lawrence (1876-1958), educated at Leipzig and Harvard, was Professor of English at Columbia University, New York, 1916-36. He begins to develop a social theory of literature, based on an underlying concept of the primarily mimetic function of literature (a 'mirror'). Chaucer is denied sublimity and, more surprisingly, pathos, but the critic observes the significant diversity of Chaucer's work, concentrating on 'The Canterbury Tales'. Reprinted from 'Medieval Story', Columbia University Press (1911), pp. 211-20.
The tales of the common folk contain many a caustic comment on the aristocratic manners of the day. We have already seen two separate tendencies in the literature of the middle classes,—the one satirical, mocking with bitter laughter at Church and State through the mouth of Reynard the Fox; the other a more dignified and good-humored protest uttered by Robin Hood. In the 'Canterbury Tales' the bitter and cynical tone is very noticeable in the criticism of life which comes from the commons. These folk have sharp tongues; they love to ridicule the errors of churchmen and the frailties of women. Chivalry had insisted on blind devotion to the gentler sex and to the majesty of religion; these people answer, with a sneer, that neither women nor clerics are any better than they should be. Most of their stories will not bear repeating. The closest modern analogues of these fabliaux, told among men in the ale-house and tavern, are our smoking-room stories, indefensibly coarse, even though indisputably humorous. The grossness of Chaucer's tales is well-known, but they have some redeeming qualities. They differ from


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1928 - 2012
Lifetime Waitsburg resident, Elmer Hays, 86,
passed away October 1, 2012, at his home.
One of ten children, Elmer was born November
7, 1928, in Waitsburg, to Robert and Elsie Sieckman
Hays. He graduated from Waitsburg High School in
1943. He served in the US Navy as a frogman during
WWII and was called back to serve in the Korean
War. He worked on seagoing tug boats in the Pacific Ocean, between the Bering
Sea, Alaska and down to California. He returned to the
Waitsburg area where he did farm work.
On November 8, 1963, he and Joan Raymond
married in Kennewick, Washington. Elmer then became
Maintenance Superintendent for the City of Waitsburg,
serving the City and its residents for 24 years, retiring
December 31, 1992. His dog, Cricket or Sandy, would
often accompany him in his truck for work.
In his earlier years, he enjoyed fishing and hunting.
He loved to cook and bake and enjoyed sharing his pies
with neighbors and friends, his home always being open
to friends and family.
Elmer is survived by his wife, Joan, at home; two
brothers: Russell (Diane) Hays of McCleary, Washington
and Robert (Cay) Hays of Yakima, Washington. He was
preceded in death by his parents, Robert and Elsie Hays;
three sisters: Doris Williams, Betty Elder and Roberta
Hays; and four brothers: Howard, Kenneth, Richard, and
Wilbur Hays.
The memorial service will be 1:00 p.m., Sunday,
October 7, 2012, at Mountain View-Colonial DeWitt, 1551
Dalles Military Road, Walla Walla, Washington. Pastor
Skip Pritchard of the College Place Presbyterian Church
will officiate. Honorary pallbearers will be Dan Katsel,
Jerry Gales, Ervin Hays and Don Elder. A luncheon will
follow at the funeral home.
Memorial contributions may be made to the Waitsburg
Ambulance Service, Walla Walla Community Hospice,
Waitsburg High School Scholarship Fund or other
personal choice through the funeral home.
Friends may write memories and sign the online guestbook at www.
mountainview-colonialdewitt. com
Use the comment form below to begin a discussion about this content.


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Hey all, a few quick questions.
Stupid me, I signed up for steelhead Half-Iron in August the day after I ran my first sprint tri (I guess I had the bug) and before I realized I had to move halfway across the country. Now I am at a new job and have way less time to train and no one to ride with, so longer rides are really hard to get motivated for. I am doing a sprint on July 29 and steelhead is the next weekend. Is this ok? Can I basically call the sprint my speedwork for the week?
Also, I am commuting to work, and its only about 14 miles round trip- but with a backpack and running from angry Nebraska motorists I actually get a pretty decent workout. Can I count these miles towards anything?
Lastly, can a person do a HIM on 8k a week in the pool, about 20 miles running and 80 or so miles (counting commuting) on the bike? I guess I need to know how much I need to step it up (and soon!).
You all have been mucho helpful in the past. I appreciate it.


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beautiful Something Tattered stamps to create backgrounds
and focal points.
|that yummy wallpaper stamp--Boudoir Antique Brocade
to see some spring-like green--which pairs well with the
sweet bird's nest image:
|bird's nest from the Nest AMOUR set
|shabby French text from the Dress and Tiara set
|the perfect crown--Letter Z Monogram set
For where your treasure is, there your heart will be, also.
Thank you for letting me share my first Something Tattered blog post with you. Did
you know Something Tattered is on facebook? Stop by and "like" the ST page HERE.
Have a wonderful Monday!


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- Filed Under
One Year Ago: 2012
? The Algoma girls track and field team won the WIAA Division 3 sectional with eight individuals qualified for state. They are Kennedy Blahnik, Whitney Ebert, Jael Cornell, Mia Cannon, Mary Huston, Lindsey Kirchman, Shante Williams and Karissa LeCaptain.
? Luxemburg-Casco golf coach Jeff Frey considers junior David Spengler one of the best players in the area. Spengler advanced as an individual qualifier for a second straight year to the WIAA state meet.
? Kewaunee County athletes experienced a gold rush at the WIAA state track and field meet last weekend in La Crosse. Local competitors combined to win five titles for the second straight year.
10 Years Ago: 2003
? Kristine Gregerson was presented a St. Norbert College Distinguished Trustee Scholarship, worth $34,000 over four years, at the Algoma High School Senior Awards program.
? Golfing with the Algoma Women's League at Alaska this week, Carol Zimmer had a birdie on Hole 3 and also came within an inch of a hole-in-one!
? The Kewaunee County Youth Soccer Association started play on Monday, June 2, with 700 youth participating.
25 Years Ago: 1988
? The new administrator of the Algoma Medical Center is Mary Dettman, who took over the position on June 1. Her goal is to have a quality facility for those in need of medical attention.
? Mabel DeVillers of Rosiere celebrated her 90th birthday on June 2, with about 100 guests at Herman's Club. Her family includes three children, 17 grandchildren and 34 great-grandchildren.
? The publisher of the Kewaunee Enterprise and the Luxemburg News for half a century, and for 12 years mayor of Kewaunee, Charles Fay Temby, 79, died Sunday evening.
40 Years Ago: 1973
? After 45 years of service, Rev. T.H. Hilgendorf, pastor of St. John's Lutheran Church of Luxemburg, is retiring from active ministry. He conducted his Farewell Service on June 17.
? SP/4 Herb Ullmann will arrive home for a one-month leave from the military, after serving in Thailand. He and his wife, Frances, have rented a cottage at Alaska.
? Mr. and Mrs. John DeCremer, 620 River Road, Kewaunee, were wed 50 years on June 5. A surprise party was held in their honor by friends neighbors and relatives.
50 Years Ago: 1963
? Chester Wolski of Milwaukee, failed to appear before Judge A.G. Murphy thus far this week. Wolski was fined $10 and $7.25 for fishing with no license on June 8.
? A cordial invitation is extended to all who read the news to come to Casco on June 23 to partake in Casco hospitality at the big church picnic. Myron Naze will furnish music for the enjoyment of all.
? Mr. and Mrs. George Raisleger entertained relatives at Konop's Hotel on Sunday evening, in honor of their son, Wayne, who was a member of the Kewaunee High School graduating class.
60 Years Ago: 1953
? A baby girl named Jean Ann was born to Mrs. Wilferd Vandenhouten, Route 1, Casco, on June 7.
? Gov. Kohler signed two bills Thursday permitting the city of Green Bay to condemn land and to build water mains from near Kewaunee to Green Bay, as the city is unable to treat the waters of Green Bay, and fresh water wells are giving out.
? Miss Ruth Stoneman, social studies instructor at the Door-Kewaunee Normal School has been notified she has been awarded a U.S. exchange grant, making it possible for her to teach in the Netherlands next year.
75 Years Ago: 1938
? Stoffel's Beehive Grocery is featuring a 3-pound can of Spry for 55 cents, Lux toilet soap, three bars for 21 cents; Rinso for 19 cents; and a pint of Miracle Whip for 25 cents.
? A new sanitary-type fountain, with a concealed spout that only runs when the valve is turned, is being installed on the corner of Milwaukee and Ellis streets. It will replace the bubbler that was won by students of Kewaunee schools for selling the most Christmas seals in this district.
? The 1938 Nash four-door sedan is available at the Dworak Motor Co. on Main Street in Kewaunee for $911 - the biggest car value in town!
90 Years Ago: 1923
? Helen Westfahl won the coaster wagon offered by the Groessl Drug Store to the child guessing the number nearest to the amount of beans in a quart jar. Helen guessed the exact number - 3,596.
? The 12-foot depth of water at the harbor mouth in Algoma is thought to be sufficient for some of the boats of the Hill Steamboat Line. Therefore, the Chamber of Commerce has announced docks will be put into condition to receive cargo.
? The Henry children are home with their parents, Mr. and Mrs. William Henry, for the summer. They are Ruth, who teaches at Hustisford; Eunice, who teaches at Juneau; and George, a student at Stout.


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Introduction / History
The Bagungu are one of the smaller language groups in Uganda, numbering about 80,000. Traditionally fishermen and pastoralists, they live on the shores of Lake Albert in the bottom of the Great Rift Valley where it is hot and dry. Most people live in mud houses with a grass roof and they keep cattle with the larger herds indicating wealth. Polygamy is common and the people are very poor.
Many years ago missionaries brought the gospel and about four denominations have churches in the area. Unfortunately very few attend church, and even though the people call themselves "Christians" only a few are believers and traditional religion which binds the people in fear is still very real. The Bagungu have been marginalized by the surrounding Runyoro people and very little development has occurred in the area. Although there are schools, the attendance rates are low and literacy, health care, sanitation and accessible water are real needs. Greater than these though, is the need for the gospel of Jesus Christ to come in power and relevance to these people.
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