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Dennis wrote:
> Can you comment on the variation "caingen" vs. "gn�m" and
> your choice here? I can see that "in gn�m" (= the deed)
> is semantically cleaner than "in caingen" (= the matter,
> business, affair; dispute, controversy, etc.). But the
> demonstrative particle "(h)�" (= this, that) looks like
> padding to get the needed seven syllables in the line.
> It also strikes me as a little recherch�. Using "�" that
> way is not exactly common, is it?
That's correct. DIL says that � is only very rarely used after nouns without being followed by a demonstrative particle, -siu or -sin. The reason why I chose gn�m-�
nevertheless is that I try to follow the MSS as long as there is no important reason to suppose something else (as in the case of the probable displacement of a stanza). It
is difficult to picture how gn�m-� could have been a misreading for caingen or the other way round. I find Thurneysen's tentative suggestion compelling that the two variants
of the stanza are independent of each other.
As you say, gn�m-� has the advantage of being "semantically cleaner". In addition to this it also makes a figura etymologica with do�rig�nus.
BTW, it must be noted that our two MSS actually have a line of 6 syllables:
in gn�m-� do�ri(g)nius
Maybe we shouldn't emend to do�rig�nus as all editors did, but rather to:
in gn�m-�-siu do�rignius
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text: Race season started last week. I have been off the bike for 2 weeks now with a horible cold. That has now developed into a nasil infection. The doc gave me some antibiotics. My spring racing season is fukct before it even began. Any way, can I salvage the remaining racing series which ends next month?

subset: commoncrawl


text:
what kind of crafts
Baking mainly. Cutting and pasting sometimes- either cutting from colored cardboard and pasting in on big sheets of paper, or cutting pictures from magazines.
My 4 yo likes to color. Otherwise, we don't do too much. They'd rather play than do crafts.
Gwen (43) David (55) Augie (5.5) Alex (4)
Construction paper snowflakes, Valentine crafts, misc. fun crafts they like.
i find things on pinterest to do with them. holiday crafts for each holiday...princess wands have been done..lots of coloring, painting, etc.


text:
What is Address Search?
Spokeo reverse address search helps people connect with their neighbors and find people by address. Search your neighborhood today to find out current residents, past residents, and family information. Find out who lives on 94th Ave today.
Other Spellings
94th Ave is also spelled 94th Avenue, 94th Avnue, 94th Avenu, 94th Aven, 94th Avn, 94th Av.
Decatur, MI
Time Zone & Current Time
Decatur, MI lies within the Eastern Standard Time (or EST). The current time in Eastern Standard Time is 05:34 PM on 11/30/2015.
Decatur, MI
Top Streets
38th St, 39th St, 40th St, 41st St, 42nd St, 44 1/2 St, 44th St, 45th St, 46th St, and 47 1/2 St
Decatur, MI
Population Demographics
Household Income
Home Value
35 years old
51% male
Local Ethnicity
Ethnicity Ratio
About Decatur, MI
Decatur is a village in Van Buren County in the U.S. state of Michigan. The population was 1,838 at the 2000 census. The village is located within Decatur Township. This town is named after war hero Stephen Decatur, Jr. Ventriloquist Edgar Bergen grew up here and a street is named for him. (more on Wikipedia)


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text:
Previous research has documented an association between income inequality and mortality in the United States. To further explore this association, this study compared census data and tax return income data for the period between 1949 and 1999 with mortality rates for each decade. Data was drawn from the U.S. Census Bureau, Internal Revenue Service, and reports from the National Center for Health Statistics and Behavioral Risk Factor Surveillance System data.
Key Findings:


text:
Page 1
The blood-forming or hematopoietic system is and has been
extensively studied for a variety of reasons. It represents the
prototype of a self-renewing biological system in that large
numbers of blood cells have to be produced daily in order to
compensate for the loss of relatively short-lived mature blood
cells. The relative ease at which blood and bone marrow
samples can be obtained and single cell suspensions prepared
has greatly facilitated in vitro and in vivo experimentation with
hematopoietic cells. Monoclonal antibodies specific for a
variety of cell surface antigens expressed on hematopoietic
cells have been produced and techniques to separate cells using
combinations of such reagents have been developed. A large
number of molecules with activity on various hematopoietic
cells are now available as are various in vitro assays to measure
functional properties of hematopoietic cells.
The hematopoietic system has been subdivided into a
hierarchy of three distinct populations (Till et al., 1964;
Metcalf, 1984). In this model the most mature cells are mor-
phologically identifiable as belonging to a particular lineage
and have very limited proliferative potential. The cells in this
most mature compartment are derived from committed prog-
enitor cells with a higher but still finite proliferative potential.
Committed progenitor cells in turn are produced by a popula-
tion of multipotential hematopoietic stem cells with self-
renewal potential, i.e. the capacity to give rise to more cells
with indistinguishable properties and developmental potential.
Self-renewal of stem cells is believed to be essential for main-
tenance of hematopoiesis over time.
Studies with cultured hematopoietic cells have shown that the
formation of hematopoietic colonies as well as the proliferation
and survival of various hematopoietic cells typically requires
the presence of 'hematopoietic growth factors', many of which
have been cloned over the last decade (Metcalf, 1989, 1993).
Many investigators have interpreted these observations as
evidence that the behavior of hematopoietic cells is ultimately
controlled by extracellular signals. This notion, together with
the possibility of purifying various hematopoietic cells with
unprecedented precision has led to frantic research efforts over
the last five years to achieve clinical useful manipulation of
blood-cell production in vitro. Two sets of observations cast
doubt about the feasibility of some of these perceived applica-
tions in the short term. First, there are a number of observations
indicating that extracellular factors do not appear to control
lineage commitment and self-renewal but instead seem to
permit exhibition of a predetermined cellular proliferative and
differentiation potential (Ogawa, 1989; Lansdorp et al., 1993;
Mayani et al., 1993). These findings suggest that the decisions
that ultimately determine the fate of hematopoietic stem cells
are not dictated by the environment but instead are controlled
by currently ill-defined, intrinsic genetic mechanisms with a
developmental component. A second hurdle to meaningful in
vitro stem cell 'expansion' is the observation that hematopoi-
etic cells, including purified hematopoietic stem cells, appear to
loose telomeric DNA with each cell division and with age
(Vaziri et al., 1994). This Commentary is focused on the role
of telomeres and telomerase in normal and abnormal
hematopoietic cells. As telomerase activity has so far not been
found in any somatic tissues (Counter et al., 1994), the findings
in the hematopoietic system appear to be applicable to other
self-renewing somatic tissues as well. More extensive and
general reviews on telomeres and telomerase have been
published elsewhere (Blackburn, 1991, 1992; Harley, 1991).
Without extremely reliable mechanisms to duplicate and
Telomere length and proliferation potential of hematopoietic stem cells
Peter M. Lansdorp
Terry Fox Laboratory, British Columbia Cancer Agency, 601 West 10th Avenue, Vancouver, BC, Canada V5Z 1L3
Journal of Cell Science 108, 1-6 (1995)
Printed in Great Britain © The Company of Biologists Limited 1995
Hematopoietic stem cells have typically been defined as
pluripotent cells with self-renewal capacity. Recent studies
have shown striking differences in the mean length of
telomeric repeat sequences at the end of chromosomes from
human hematopoietic cells at different stages of develop-
ment. The most likely explanation for these observations is
that hematopoietic stem cells, like all other somatic cells
studied to date, lose telomeric DNA upon each cell division.
In this review, limitations in the replicative potential of
hematopoietic stem cells are discussed in the context of
possible clinical use of such cells for transplantation and
gene therapy.
Key words: telomeric DNA, proliferative potential, self-renewal,
hematopoietic stem cell
Page 2
segregate complete copies of the genome into daughter cells,
life in any form could not exist. It seems certain that given this
importance, many factors and pathways involved in securing
the fidelity of gene duplication and chromosome segregation
remain to be uncovered. Recently, the role of telomeres in
some of these processes has received increased attention.
Telomeres are the physical ends of eukaryotic chromosomes
and contain both DNA and protein (Blackburn, 1991). Various
functional properties of telomeres were recently reviewed
(Blackburn, 1994). The DNA component of telomeres consist
of (TTAGGG)nin all vertebrates including humans. Telomeres
distinguish intact from broken chromosomes (Sandell and
Zakian, 1993). This distinction is important because the ends
of broken chromosomes (but not intact telomeres) indirectly
induce cell cycle arrest and chromosome repair before cells can
proceed to cell division(s). Telomeres furthermore appear to
stabilize chromosome ends, in that telomeres (but not broken
chromosomes) are protected from nuclear degradation and
end-to-end fusion. Telomere proteins are likely to be involved
in the positioning of telomeres and chromosomes within the
nucleus and are important for the spatial structure of telomeres
and chromosome segregation (Giraldo and Rhodes, 1994;
Chikashige et al., 1994). Finally, telomeres appear to play an
important role in the replication of the very end of chromoso-
mal DNA.
Two characteristics of the DNA polymerases involved in dupli-
cation of DNA prior to cell division are: (1) the requirement
of label RNA primers to initiate DNA synthesis; and (2)
synthesis of new DNA in the 5′r3′ direction only. That these
characteristics pose a problem for the complete replication of
the 3′ end of linear chromosomes was realized by Olovnikov
(1971, 1973) and Watson (1972), who described it as the 'end
replication problem' (Fig. 1). The effect of the end replication
problem on DNA duplication at chromosome ends is illustrated
in Fig. 2. From this figure, it can be understood that the 3′ ends
of all linear chromosomes are expected to shorten progres-
sively with each round of DNA duplication (Levy et al., 1992).
It now appears that such chromosome shortening can indeed
be observed in all human somatic cells studied to date,
including primitive hematopoietic cells from adult bone
marrow (Vaziri et al., 1994).
A number of studies have documented that the length of
telomeric (TTAGGG)n repeats in human cells decreases with
in vitro and in vivo cell divisions (Harley et al., 1990; Hastie
et al., 1990; Lindsey et al., 1991; Counter et al., 1992; Allsopp
et al., 1992; Vaziri et al., 1993). In these studies, telomeric
length showed considerable variation between individuals and
between different tissues. Studies with cultured fibroblasts
have indicated that telomere length is a better predictor of
replicative capacity than the actual age of the fibroblast donor
(Allsopp et al., 1992). On the basis of these studies, it appears
that loss of telomeric DNA (and resulting cell cycle exit
signals) may adequately explain the observation by Hayflick
and Moorhead that normal human fibroblast become senescent
after a fixed number of doublings in vitro (Harley, 1991). This
possibility has been expanded by Harley into the 'telomere
hypothesis of cellular aging' (Harley, 1991; Harley et al.,
1992). Several recent observations are in agreement with pre-
dictions of this theory and it appears that the possible impli-
cations of telomere biology could be wide-spread indeed. Not
only could measurements of telomere length be used to
estimate the proliferative potential of cells or, by repeating
measurements over time, the in vivo turn-over rate of cells and
tissues, but such measurements should also be valuable in
studies of aging and associated disorders. More information on
P. M. Lansdorp
Fig. 1. Schematic illustration of the end replication problem.
Somewhere along the 3′ terminus of single-stranded DNA a specific
RNA polymerase will synthesize a short stretch of nucleotides that is
complementary to the DNA template. This RNA serves as a primer
for DNA polymerase, capable of forming DNA from the template in
the 5′ to 3′ direction of the newly formed strand only. Hydrolysis of
the RNA primer and untranslated nucleotides upstream of the 5′ end
of the primer results in a region of untranslated DNA at the 3′ end of
the DNA template.
Fig. 2. The effect of the end replication problem on DNA duplication
at chromosome ends. Newly synthesized DNA is indicated by the
hatched bars. Arrows indicate regions of untranslated DNA at the 3′
end of the original DNA strands (top) after a complete round of
replication (bottom) (see also Fig. 1).
Page 3
3 Telomere length in stem cells
the role of telomeres in cellular aging may furthermore lead to
meaningful predictions of organ failure with implications in
diverse areas such as gerontology and preventive medicine.
A major problem in the exploration in some of these possi-
bilities is that telomere length measurements currently require
DNA from at least 105cells and that such assays are time
consuming. Typically, DNA (extracted from 1×106to 2×106
cells) is first digested with restriction enzymes that cleave
internal but not telomeric sequences. The resulting fragments
are separated by gel electrophoresis, immobilized and
hybridized with 32P-(CCCTAA)3. Specifically bound telomere
probe results in a smear on autoradiographs that ranges
between 10 and 15 kb for 'young' and 5 and 10 kb for 'old'
cells. Results of these experiments are typically expressed as
the mean telomere restriction fragment (TRF) size (in
kilobases) after quantitation using densitometry. The actual
size of telomeric repeats is shorter because the restriction
enzymes used cut 2-5 kilobases upstream from the start of the
telomeric repeats themselves (Harley, 1991). The presumed
heterogeneity in TRF length between cells within a tissue and
between individual chromosomes make alternative measure-
ments of telomere length highly desirable. Ideally, such mea-
surements should be done on individual cells. Alternatives that
are being explored are in situ hybridization and immunologi-
cal methods for quantitation of proteins that bind specifically
to telomeric repeats (Palladino et al., 1993). Potential problems
with both approaches may be the presence of sequences with
homology to telomeric repeat sequences at subtelomeric or
intra-chromosomal sites. The presence of the latter is particu-
larly a problem in inbred mice, and has prevented the use of
this animal model in studies of telomeres and cellular aging
(de Lange, 1994).
Most, if not all, somatic human cells lose 50-100 bp of
telomeric DNA with each successive round of cell division
(Harley et al., 1990; Allsopp et al., 1992; Vaziri et al., 1993,
1994). Because such cells 'start' their proliferative life at an
unidentified point in fetal life with 5-10 kb of (T2AG3)n
repeats, the replicative capacity of early fetal cells is expected
to be of the order of 50-200 doublings. Even 50 doublings rep-
resents a tremendous proliferative potential, which can, in
theory, yield up to 1015cells or approximately 1000 kg of cells.
Differentiation and cell death will almost certainly limit the
actual size of clones to a fraction of this estimate. The actual
proliferative potential of cells may furthermore be less, as the
exact length of telomeric repeats required for full telomere
function is not known. In addition, the length of telomeric
DNA repeat sequences will vary to some extent between indi-
vidual chromosomes (Moyzis et al., 1988), presumably
limiting the proliferative potential of cells to the chromosome
with the shortest length of such repeats.
As discussed above, the replicative potential of somatic cells
is expected to decrease as a function of their proliferative
history. How does critical shortening of telomeres signal cell
cycle exit and cellular senescence? Some answers to this
important question have emerged from elegant studies in yeast
(Sandell and Zakian, 1993). It was found that inducible elim-
ination of a telomere on a single chromosome resulted in arrest
of the cell cycle at the G2 checkpoint. Interestingly, many of
the yeast cells ultimately recovered from the arrest without
repairing the damaged chromosome. Such damaged chromo-
somes were much more likely to be lost upon division than
chromosomes with intact telomeres (Sandell and Zakian,
1993). From this study, it appears that loss of telomeric DNA
induces the same cellular machinery (cell cycle arrest, DNA
repair) as broken chromosomes and that intact telomeres have
important functions, by allowing cell cycle progression and
avoiding chromosome loss.
If somatic cells are indeed limited by the length of their
telomeric DNA to a finite replicative capacity, this could be an
important natural barrier to prevent unlimited proliferation by
malignant clones. It is currently not known whether this
mechanism indeed limits the growth of certain tumors. Fur-
thermore, given a proliferative potential of 50-100 doublings,
it can easily be envisioned how some tumors could kill their
hosts without exhausting available telomere DNA at the time
of the initial malignant transformation. Nevertheless, it now
appears that malignant human tumors may use the same
mechanism by which cells of the germ line presumably remain
immortal: expression of the enzyme telomerase (Counter et al.,
1992, 1994; de Lange, 1994). Telomerase synthesizes
telomeric repeats using an RNA template complementary to
the G-rich repeats on the 3′ telomeric chromosome end
(Greider and Blackburn, 1985; Blackburn, 1992). The human
gene(s) encoding for this remarkable RNA-dependent DNA
polymerase (a reverse transcriptase) have not yet been cloned.
However, biochemical assays, using substrates of artificial
telomeric repeats, have provided clear evidence for the
existence of telomerase activity (Counter et al., 1992, 1994).
Interestingly, this enzyme activity has been found so far only
in immortal human cell lines (Counter et al., 1992) and certain
human tumors (Counter et al., 1994) but not in primary somatic
cells from normal individuals (Counter et al., 1992, 1994).
These observations suggest that telomerase could be a tumor-
specific enzyme and that non-toxic inhibitors of this enzyme
may be useful chemotherapeutic agents in the management of
patients with certain malignant tumors (Counter et al., 1994).
When DNAs from fetal liver cells, umbilical cord blood cells
and adult bone marrow cells were compared, a striking and
highly significant (P≤0.0001) difference in the mean length of
terminal restriction fragments (containing the (T2AG3)n
telomeric repeats) between the fetal/neonatal and adult tissues
was observed (Fig. 3). The observed loss of telomeric DNA in
these hematopoietic tissues appears not to be restricted to more
mature cells as purified CD34+CD38−primitive progenitor
cells from adult bone marrow were also found to have shorter
telomeres than fetal liver cells (Vaziri et al., 1994). In these
studies, there also appeared to be an age-related loss of
telomeric DNA. The measured rate of telomere loss in lym-
phocytes was calculated to reflect 0.4 stem cell doubling/year
(Vaziri et al., 1993), whereas the corresponding value was 0.25
stem cell doubling/year for (limited) adult bone marrow data
Page 4
(Vaziri et al., 1994). Considerable variation in the mean
telomere length between individuals will require extension of
these studies to a larger number of samples in order to obtain
more accurate estimates of in vivo cell turn-over. Interestingly,
leukemic blast cells from a pediatric patient were found to have
significantly shorter telomeres than normal cells from the same
patient (Adamson et al., 1992). These findings are in support
of proliferation-dependent loss of telomeric DNA in cells of
hematopoietic origin. The most straightforward explanation for
these combined observations is that hematopoietic stem cells
do not express telomerase, have a very low turn-over rate in
adults and decrease their proliferative potential with each
division and, as a consequence, with age. However, the possi-
bility that minor populations of CD34+CD38−stem cells either
stop dividing at a fetal cell stage or, alternatively, express
telomerase activity and by either mechanism maintain 'fetal
length' telomeres throughout life has not been formally
excluded. Techniques that could be used to measure telomere
length and telomerase activity in individual cells would be
extremely useful in the further study of these possibilities.
Several observations with murine as well as human cells are
in agreement with there being a finite number of divisions of
early hematopoietic cells and some investigators have specu-
lated about the nature of such restrictions. In discussing dif-
ferences between embryonic and adult stem cells, Metcalf and
Moore (1971) calculated that embryonic (murine) stem cells
can undergo 20-80 more doublings than equivalent cells from
adult marrow (Metcalf and Moore, 1971). As one of the
possible explanations for the calculated differences, these
authors proposed that stem cells may be programmed to
undergo a fixed number of divisions. Reincke et al. (1982)
observed limitations in the proliferative capacity of normal and
irradiated stem cells in long-term bone marrow cultures. The
invariable occurrence of cellular senescence after a fixed
number of doublings was interpreted as indicating a general
biological limit to the division capacity of cells. Other reports
documenting that embryonic and fetal hematopoietic cells have
a higher in vivo (Rosendaal et al., 1979; Albright and
Makinodan, 1976) and in vitro (Nakahata and Ogawa, 1982;
Hows et al., 1992; Lansdorp et al., 1993) proliferative potential
than adult hematopoietic cells may also be in support of there
being absolute limits in replicative capacity. Similarly,
numerous observations indicating limitations in the prolifera-
tive potential of stem cells using serial transplantation experi-
ments (Metcalf and Moore, 1971; Moore, 1992) could be inter-
preted as providing support for possible telomere-related
restrictions in the proliferative potential of hematopoietic cells.
A detailed review of these studies is thought to be outside the
scope of this Commentary as the fate of primitive hematopoi-
etic cells in vitro and in vivo is undoubtedly controlled by a
variety of intrinsic and extrinsic factors, each of which may
have contributed in various degrees to these observations.
If all hematopoietic stem cells show age- and proliferation-
dependent shortening of telomeric DNA, several notions about
the 'self-renewal' of stem cells and their use in transplantation
and gene therapy probably need to be revised. Culture of
purified candidate stem cells with the goal of expanding their
number would have to take ultimate telomere-related restric-
tions in their replicative potential into account. From this per-
spective, the use of fetal liver (Lansdorp et al., 1993) and cord
blood cells (Broxmeyer et al., 1992) appears to have significant
advantages over cells derived from adult peripheral blood or
bone marrow. The ±4 kb of extra telomeric repeats that cord
blood and fetal liver cells have in comparison to cells from adult
bone marrow (Fig. 3) represent an estimated extra proliferation
potential of 20-40 cell doublings (assuming loss of 100-200 bp
of telomeric DNA per cell division). Even a minimal estimated
difference of 20 doublings could produce, in theory, a 106-fold
difference in cell numbers generated from cord blood versus
adult progenitor cells. Clearly, this number compares
favourable with the 7- to 30-fold fewer CD34+progenitor cells
that can be directly harvested from cord blood compared to
adult bone marrow (Broxmeyer et al., 1992). In order to take
advantage of this theoretical superiority of cord blood cells, it
will be important to understand how their extensive prolifera-
tion potential can be selectively exploited in order to increase
the number of transplantable stem cells. At this point, it seems
unlikely that growth factors alone will be sufficient to achieve
such net expansion of cord blood stem cells. For this purpose,
studies towards determining the genetic mechanisms that ulti-
mately determine the fate of very primitive hematopoietic cells
may be more rewarding. The selective expression of certain
transcription factors in the most primitive normal hematopoi-
etic cells such as homeobox genes A2, B3 and B4 (Sauvageau
et al., 1994) may provide a starting point for such studies. If
self-renewal decisions of stem cells could be manipulated in a
meaningful way, such measures would most likely need to be
combined with techniques that allow induced extension or
maintenance of telomere length in order to be clinically useful
with cells from adult tissues. Clearly such sophisticated cellular
engineering techniques require a few breakthroughs and will
not be available in the immediate future.
In view of the likelihood that telomere length ultimately deter-
mines the replicative capacity of hematopoietic cells, the word
proliferation potential should probably be used with caution. It
now seems reasonable to distinguish cell biological or func-
tional from telomeric or genetic restrictions in the number of
P. M. Lansdorp
Fig. 3. Differences in mean length of telomere restriction fragments
(TRF) of hematopoietic cells from fetal liver (FL), cord blood (CB)
and bone marrow (BM, 4 donors aged 40, 51, 52 and 58 years).
Values of the mean and standard error of TRF measurements are
adopted from Vaziri et al. (1994).
Page 5
5 Telomere length in stem cells
divisions a cell can potentially undergo. Thus, hematopoietic
cells may differ in replicative capacity as determined by the
length of their telomeres and yet have similar functional pro-
liferative potentials.
It is possible that the functional proliferative potential of
primitive hematopoietic cells is somehow linked to the length
of telomeres in such cells. This notion is certainly in agreement
with the higher proliferative capacity of fetal and cord blood
cells as compared to cells with a similar phenotype purified
from adult bone marrow (Lansdorp et al., 1993). However, a
more likely explanation for this correlation is that the proba-
bility of self-renewal (reflected in the replating potential of
cells) changes with different stages of development, similar
perhaps to the well-known developmental control of hemoglo-
bin gene expression. Without conditions that allow full display
of actual genetic replicative capacity, correlation between
telomere length and functional proliferative potential are likely
to be coincidental. It could be argued that all correlations
between telomere length and replicative history/proliferative
potential of cells that have been observed to date are just that:
correlations. Although numerous observations discussed in this
Commentary are in agreement with the functional involvement
of telomere length in determining the number of divisions a
cell can undergo, direct proof of this linkage in normal cells
has not yet been provided. For this reason, expression of
endogenous or exogenous functional telomerase activity in
normal somatic cells and demonstration that this results in
extension of their proliferative potential are eagerly awaited.
This work was supported by NIH grant AI29524, and by grants
from the Medical Research Council and the National Cancer Institute
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USA (in press).


text:
Bill Murray, left, Bugs Bunny, and Michael Jordan are shown in a scene from the Warner Bros. film 'Space Jam.' Detroit native Billy West voiced Bugs Bunny in the movie.
- Filed Under
Although Detroit native Billy West - renowned for multiple roles on "Futurama" - has voiced Bugs Bunny and Elmer Fudd, he feels uncomfortable being called the new Mel Blanc.
"There's no way you can compare me to Blanc (the original voice of Bugs Bunny and the major "Looney Tunes" characters)? The best stuff Looney Tunes ever did was before I was born and has never been duplicated since," explained West, 61, of Los Angeles.
West voiced the two aforementioned characters most notably in 1996's "Space Jam," the animated/live-action movie co-starring basketball legend Michael Jordan. ...


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Playing now in college hockey: "Survivor: WCHA."
UAA athletic director Steve Cobb said Thursday he will attend a meeting in Minnesota next week that will bring together athletic directors from the five Western Collegiate Hockey Association schools that would remain if reports prove true that five other members of the 12-team conference intend to form their own super conference in 2013.
Cobb said he will join athletic directors from Michigan Tech, St. Cloud State, Minnesota State-Mankato and Bemidji State as well as WCHA administrators for the meeting.
The gathering was planned amid growing reports that the WCHA, which has been around since 1951, faces the defection of five teams.
"It does appear the WCHA is breaking up," Cobb said. "We're confident enough about it that we're going to Minnesota next week to talk."
It's been known for awhile that the league will lose stalwarts Minnesota and Wisconsin in 2013-14 when the Big 10 hockey conference debuts.
But now, according to Cobb and several newspaper reports that cite unnamed sources, half of the remaining WCHA teams will soon announce their decision to leave the league and form what Cobb is calling "a super six conference" for the 2013-14 season.
The teams are North Dakota, Colorado College, Denver, Minnesota-Duluth and Nebraska-Omaha. A sixth team, Miami of Ohio, would come from the Central Collegiate Hockey Association, Cobb said.
"I don't think anybody saw this coming," he said.
A call to WCHA commissioner Bruce McLeod was not immediately returned Thursday. Cobb said that at the annual WCHA meeting in April, there wasn't a hint that any school was thinking about leaving the league.
"At our meeting in April we voted to extend an invitation to Miami and Notre Dame," Cobb said, referring to a pair of CCHA teams. "That passed with 100 percent of the vote. Nobody said they were unhappy. We left the April meeting and basically some of them contacted Notre Dame and Miami and said, 'Don't take the WCHA invitation, we're going to invite you to join our super league.'
"I blame everybody for being less than honest with their own league members. It's a really sneaky back-door deal."
The shakeup comes a couple months after the Big 10 conference announced it will field a hockey league for the 2013-14 season. That decision will take Minnesota and Wisconsin out of the WCHA and Michigan, Ohio State and Michigan State out of the CCHA and put them in a conference with Penn State, which is creating a hockey program.
If left with just five teams, the WCHA would lose its automatic berth to the NCAA tournament; six teams are required to receive an automatic berth.
The CCHA could be left with fewer than six teams too. Currently home to 11 teams, the CCHA will lose three to the Big 10 and might lose as many as three to the new super conference, according to a Thursday report by the Grand Forks (N.D.) Herald.
Citing multiple unnamed sources, the Herald reported that two other CCHA schools, Notre Dame and Western Michigan, could also be part of a super conference. It also reported that North Dakota will join Duluth, Denver, Colorado College and Omaha in the super conference.
Where this leaves the WCHA -- and UAA -- is uncertain.
The WCHA and CCHA could merge, Cobb said, which would put Alaska's two college hockey teams in the same league. But whether a single conference will want two Alaska teams is the question. Back when UAA and UAF gained entry to conferences, the WCHA took UAA and the CCHA took UAF so that neither league wound up with both Alaska teams.
"It's tough selling two trips to Alaska in one year," Cobb said.
In the meantime, the WCHA will remain a 12-team league for another two seasons -- although whether that means it will be one big happy family remains to be seen.
"I'm not offended at all they want to start a conference. I'm very offended at the way it was handled," Cobb said. "We've got two years left, and I assume it's going to be very tense and very uncomfortable."
Reach Beth Bragg at email@example.com or 257-4335.
By BETH BRAGG


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April 24, 2013
Kent Hendrix, 47, draws his sword near his house Tuesday, April 23, 2013, in Salt Lake City. Hendrix, a Samurai sword-wielding Mormon bishop came to the aid of a woman who was being attacked in front of his house. Hendrix woke up Tuesday to his teenage son pounding on his bedroom door and telling him somebody was being mugged. Hendrix grabbed a 29-inch Samurai sword and rushed out the door. He says the man attacking a woman jumped back and ran down the street after he drew the sword. The man was chased until he jumped in his car and drove away. (AP Photo/Rick Bowmer)
Stories this photo appears in:
Mormon bishop with Samurai sword runs off attacker
Wednesday, April 24th, 2013 5:49 a.m.
SALT LAKE CITY (AP) — A Samurai sword-wielding Mormon bishop helped a neighbor woman escape a Tuesday morning attack by a man who had been stalking her.


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Hello all,
i just installed 7.x-1.x-dev version of commerce coupon module in my drupal commerce site.I created an 10% percentage discount and activated it.It got discounted from the order total when i loggedin as admin.
But when i use the coupon code as an anonymous user, it always throws an error "Coupon code is not valid".Can anyone please guide me to overcome this issue.
Thanks to all
Comment #1pcambra CreditAttribution: pcambra commented
|» Postponed (maintainer needs more info)
It is working for me as anonymous exactly the same as authenticated users.
Coupons are applied through rules, you can enable rules debug and post the results here, maybe the coupon code is not ok?
Comment #3pcambra CreditAttribution: pcambra commented
As I said, this is working normally, so other than advising you to have the latest versions of both commerce and coupon modules, I'd need more info to help
Comment #6esoteric1 CreditAttribution: esoteric1 commented
when you uninstalled and reinstalled did you look at the permissions for the modules?


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Nikon Coolpix L24
Nikon Coolpix L24 : Angle Sure it features a nice, big LCD, but the Nikon Coolpix L24 is lacking when it comes to image quality. Its auto mode and in-camera help system are desirable if you're a newbie, but you will likely be disappointed by the camera's noisy images at almost every ISO.
6 / 6


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Go to exotic Norway.
Detour - A Peek of Norway in
Washington, D.C. Along the fjords, waterfalls, mountains, coasts
and countryside of Norway runs 18 National Tourist Routes. The Detour
project is a collaboration between the Norwegian Public Roads
Administration and the foundation Norsk Form. Close to 200 architectural
projects have sprung up along these routes, in the form of lookouts,
information centres, picnic areas, and observation platforms designed as
striking landmarks. Visitors will have the opportunity to explore the
magnificent and varied natural landscape, as well as some of the
architectural achievements, along popular tourist routes in Norway.
National Building Museum in Washington, DC, from January 29 to May 25,
2009. For more information please see Detour Online.
Book your Norway package through Picasso Travel Nordique Tours by Picasso Travel offers the best way to explore the beautiful coastline of Norway visiting its world famous fjords and charming towns along the way. Seeing the fjords is an experience of a lifetime - magical, mystical, astounding, and with a choice of 3, 4, 5, and 7 night packages Nordique Tours is sure to have the perfect option for you. Call your favorite travel agent or 1-800-995-7997. www.picassotravel.com/norway/norway_co.html
Juvet An enriching meeting
with rugged Norwegian scenery, cultural history and modern architecture.
By the Gudbrandsjuvet (Gudbrand's ravine), between the Trollstigen Road
and the Geirangerfjord, a tourism enterprise has been established that is
somewhat out of the ordinary. A landscape hotel that offers a short stay
holiday concept based on geotourism comprises of ten detached hotel rooms
on separate sites in virtually untouched landscape. Each room has its own
unique view of this craggy Norwegian scenery. In the high season our
guests are offered a five day stay complete with activities and
experiences organized in the Western Norwegian fjord landscape. Due to
open this summer! For more information and booking see: www.juvet.com.
Brekke Tours: Your Scandinavia Specialist Explore Scandinavia and the unique cultures of each country! Our escorted tours feature exciting itineraries and encompass regions not always featured in other tour packages. Explore your roots with our Norwegian Heritage tours or if you prefer to travel independently, let us design an itinerary specifically for you. Inquire about our special discounts for groups! To view escorted tour itineraries and independent travel options, request a brochure at 1-800-437-5302 or visit us online at www.brekketours.com.
Tromsø - Midnight Sun Capital For more than 2 months in summer, the sun remains above the horizon, bathing Tromsø in a golden glow at midnight. Glaciers walking in the Lyngen Alps, kayaking on the fjord, deep sea fishing or whale watching in the Atlantic are ways to enjoy this endless light. Do also look for atmospheric seafood restaurants, well-populated cafes, bustling festivals and thought-provoking art. The Tromsø summer is untamed natural beauty and elegant city chic, day and night. www.visittromso.no
Hadeland Glassverk Spring Sale 2009 - get your hands on the hottest European glassware The spring sale 2009 will take place from March 19 to April 8. With 30 - 80% reductions on designer and quality glass, we have many excellent offers in all our nine shops. Dinner and coffee services, carafes, cutlery, wine glasses and much, much more at mad spring prices! Bring along the entire family for a fun day shopping, plus you can combine enjoyable activities in the Hadeland region, with the good bargains at the Hadeland Glassverk. www.hadeland-glassverk.no
Contact Forum Hadeland - America Hadeland is a region in the south eastern part of Norway, about 50 minutes drive from Oslo. The Contact Forum assists members of the Hadeland Lag of America free of charge with genealogy research, ordering of overnight stay and car rental. It also assists in finding the places from which their ancestors left, and eventually family members in Hadeland. This is a collaboration project between the historical societies of Hadeland and Hadeland Lag of America. For more info: www.hadelandlag.org and www.visithadeland.no.
Oslo - Capital Cool! Winter still has a hold on Oslo in March. Although the days are getting longer and brighter and remind us that spring is just around the corner, there are still good skiing conditions in the Oslo forest, whether you prefer cross-country or downhill-skiing. In the Vigeland Sculpture Park, not far from the city center, a whole day of ski events for children takes place on March 8th. 7000-9000 children meet to compete, drink hot chocolate, eat hot-dogs and enjoy themselves in the snow. It's known to be the world's largest ski event for children. www.visitoslo.com/en
Save money with the Bergen Card
How long are you planning to stay in Bergen? With a Bergen Card, there are plenty of activities to keep you
occupied for at least 48 hours. Get ready to explore Bergen, the City of
Culture, the practical and inexpensive way! With your Bergen Card, you can
enjoy free bus travel within the city limits, free admittance to most
museums and attractions and discounts on a variety of cultural and
sightseeing attractions and parking. For more information and more news
from Bergen, please go to www.visitBergen.com/newsletter. There you can also
register and receive information about new and existing tourism products,
cultural events and other events in Bergen.
Hurtigruten 50% Off North and
Southbound coastal voyages - There's no time like now to step board
Hurtigruten - and into adventure! Our unique upscale cruises along
Norway's majestic, rugged coast and through its magnificent fjords, known
as the "World's Most Beautiful Voyage," are legendary. Book selected 7 and
6-day Norwegian Coastal Voyages departing May 1 - June 15, 2009 and
receive 50% off. For more information visit us at www.hurtigruten.us.
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NEW YORK, Nov. 2, 2012 /CNW/ - MDC Partners Inc. will participate in the Wells Fargo Securities Technology, Media and Telecom Conference at The New York Palace Hotel in New York on Wednesday, November 7, 2012. David Doft, Chief Financial Officer, will participate in a fireside chat at 11:05 AM (ET). A live, audio webcast will be available to the public by visiting www.mdc-partners.com. The webcast will be available in replay for six months following the presentation. MDC Partners Inc. will also participate in the BMO Digital Media Conference at The Grand Hyatt Hotel in New York on Thursday, November 8, 2012. Kip Voytek, Senior Vice President, Director Digital Innovation, will present at 11:30 AM (ET). A live, audio webcast will be available to the public by visiting www.mdc-partners.com. The webcast will be available in replay for one year following the presentation. About MDC Partners Inc. MDC Partners is one of the world's largest Business Transformation Organizations that utilizes technology, marketing communications, data analytics, insights and strategic consulting solutions to drive meaningful returns on Marketing and Communications Investments for multinational clients in the United States, Canada, Europe, Latin America and the Caribbean. MDC Partners' durable competitive advantage is to Empower the Most Talented Entrepreneurial Thought Leaders to Drive Business Success to new levels of Achievement, for both our Clients and our Shareholders, reinforcing MDC Partners' reputation as "The Place Where Great Talent Lives." MDC Partners' Class A shares are publicly traded on NASDAQ under the symbol "MDCA" and on the Toronto Stock Exchange under the symbol "MDZ.A". ____________________________________________________________________________________________________________ | | | |________|___________________________________________________________________________________________________| |CONTACT:|David Doft | |________|___________________________________________________________________________________________________| | |Chief Financial Officer | |________|___________________________________________________________________________________________________| | |646-429-1818 | |________|___________________________________________________________________________________________________| | |email@example.com| |________|___________________________________________________________________________________________________| (Logo: http://photos.prnewswire.com/prnh/20120221/NY57031LOGO) http://www.mdc-partners.com http://photos.prnewswire.com/prnh/20120221/NY57031LOGO PRN Photo Desk, email@example.com SOURCE: MDC Partners Inc. To view this news release in HTML formatting, please use the following URL: http://www.newswire.ca/en/releases/archive/November2012/02/c4465.html CO: MDC Partners Inc. ST: New York NI: ADV PUB FIN SHOW CONF -0- Nov/02/2012 13:01 GMT
MDC Partners to Participate in Upcoming Investor Conferences
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SportsDay columnist Kevin Sherrington hosted a chat Wednesday to talk everything sports. Here are some of the highlights:
Question: For the longest time, Ron Washington was credited with getting the most out of his players. When I watch Andrus and Choo, I'm seeing their worst. Not all Ron's fault, but are guys tuning him out?
Sherrington: You can't really use Choo as an example because he just got here. I didn't know his game very well before he got here. I knew he was a great hitter with great eye at the plate, and I knew he was an iffy outfielder. Turns out more than iffy. He should be a full-time DH. But, like Fielder, he doesn't want to be a full-time DH. Tough, I say. They need to lay down the law after this season. As for Elvis, I'd say his future with the team is very cloudy. He's not shown any progress as a hitter the last two seasons. And this isn't the '60s. You can't get by with a good defense/spare offense SS. Not when he's being paid so handsomely. I'd say Elvis is playing the second half for his job next season.
Question: Joe Saunders reminds us how tough it is to stink it up on the big stage. Do you get the feeling before the game he'd been told that O's start was his last if he didn't impress someone?
Sherrington: Nobody tells a veteran something like that. He simply made it easy for them. He's been a huge disappointment for the Rangers, simply because they thought he could rack up some innings for them. He used to do that every year. But the guy has been a human fireworks show this year. The Rangers did what they had to do in designating him for assignment. Might as well give a younger pitcher a shot. The problem is, do you bring up a young guy, watch him get lit up, then worry about how it affects his development? These are the dilemmas facing the Rangers these days.
Question: I heard a radio update that gave a Nelson Cruz highlight and said it was tough for the Rangers fan to take. It sure looked like he didn't actually want to be here, not that Texas lost him when it came to free agency. Is that your understanding?
Sherrington: I've never gotten a satisfactory explanation on the Cruz situation. I know they wanted to keep him at first. I saw Levine, the assistant GM, give Cruz a hug in the clubhouse after the Rangers were eliminated last season. Apparently there were some hard feelings in the organization about the fact that Cruz took the suspension instead of appealing. Had he appealed and played, you could make the argument that the Rangers would have finished better. Of course, it would have hurt his contract situation, which apparently was the advice he received. So that was strike 1. He also wanted to play full-time in the OF, and the Rangers were only interested in him as a DH. He turned down the Rangers' initial offer because of that. Then everything went south on him in the market, and he had to settle on a one-year deal with Baltimore. It's not clear to me whether the Rangers tried to trump Baltimore. If they didn't, they should have, and I wrote that before the season. Whatever his fielding issues, they're no worse than Choo's. And he would have been a much-needed bat in the middle of the lineup. That was clear even before this season unraveled.
On Twitter:
@KSherringtonDMN @SportsDayDFW @dallasnews


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I'll be honest: Happy as I am with my iPhone 4, I want the iPhone 4S. Because, you know, it's better. But I can't justify the expense, especially when the new model brings relatively few big features to the table.
If you feel the same way, here's good news: you can trick out your iPhone 4 (and even your 3GS) so that it's more 4S-like. And you'll spend considerably less money in the process. Take better pictures
Arguably the biggest hardware change to the iPhone 4S is its souped-up 8-megapixel camera. While there's no way to raise the resolution of your iPhone 4's 5-megapixel camera, there are things you can do to improve picture quality and convenience.
For starters, dump the stock Camera app in favor of one that gives you more control over shot settings and image editing. One popular choice is Camera+, which is currently on sale for 99 cents (down from $3.99). Among other things, it lets you set exposure separately from focus (Apple's Camera app ties them together), stabilize shaky shots, and choose from 16 preset scene modes. From there you can apply effects, add borders, and so on.
Meanwhile, one area users often overlook is the iPhone camera lens, which can easily get obscured by smudges and fingerprints. Using a soft, clean cloth, wipe the lens clean every few days. (Well, the glass covering the lens, anyway.) You'll be surprised how much this can improve your pictures.
Use Vlingo
By now you've no doubt heard about Siri, the super-cool voice-powered personal assistant that's coming to the iPhone 4S. Alas, iPhone 4 and 3GS users are out of luck, as the software requires more processing power than those models can muster.
Thankfully, there's Vlingo, a free app powered by voice commands–just like Siri. With Vlingo you can send e-mail and text messages, run a Web search, get driving directions, find nearby coffee shops, update Facebook and Twitter, and more. It works amazingly well, and you no longer have to pay extra for the e-mail and texting capabilities; every feature is now free. Plus unlike Siri, Vlingo is available right now–for all iPhone models.
Improve performance
The 4S is Apple's first iPhone to incorporate a dual-core processor, meaning it should be faster at just about everything. If your single-core iPhone is feeling sluggish, there are ways to give it a little speed boost.
For starters, reboot, especially if you routinely install a lot of new apps. I'd recommend doing this at least once a week. Also, if you keep a lot of Web pages open in your Safari browser, close them. More pages use more memory.
Finally, there's anecdotal evidence to suggest that you can improve 3G performance by turning off as many Spotlight Search elements as possible. (You can find these in the Settings app in the General section.) Not sure why, but it seems to help.
Install iOS 5
The iPhone 4S will ship with iOS 5 already preloaded, but iPhone 4 and 3GS users can get the exact same operating system starting Oct. 12. The update includes over 200 new features, so it's kind of like getting a brand-new phone.
Among the highlights: Notification Center, which makes all notifications available with a swipe of your finger and adds them to the iPhone's Lock Screen; iMessage, a free text-messaging app for communicating with other iDevice owners; and Reminders, a long-overdue task list. Even your iPhone's camera gets an overhaul of sorts as iOS 5 turns the volume-up button into a shutter release.
Improve battery life
One of the best things about a new iPhone is its new battery. If your handset is a year old, chances are good its battery is starting to lose some capacity (which happens to all rechargeable batteries over time). Alas, iPhones have no battery doors, so you can't just swap in a fresh one.
Actually, you can–it just takes a little doing. Check the Installing iPhone Battery guide over at iFixit, for example, and you'll see that a battery swap is little more than a six-step process.
Then head to eBay, where a search for "iPhone 4 battery" reveals options priced as low as $5.99. Yep, you read right, a mere six bucks buys you a brand new battery for your phone. That said, I recommend spending a few dollars extra to get a kit that includes the few tools you'll need to perform this minor surgery.
Self-proclaimed cheapskate Rick Broida has been a technology writer for over 20 years. He has authored over a dozen books, including, most recently, "How to Do Everything: Palm Pre." Currently he writes the Cheapskate blog.


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|RIT Scholars content from RIT Digital Media Library has moved from http://ritdml.rit.edu/handle/1850/10237 to RIT Scholar Works http://scholarworks.rit.edu/article/1010, please update your feeds & links!
|An Integer programming approach to the construction of trend-free experimental plans on split-plot designs
|Carrano, Andres; Thorn, Brian; Lopez, Guillermo
|In many experimental designs, the standard procedure involves randomization of the factor-level combination run order. There are cases, however, where it Is known that a time or position trend that can seriously compromise the results of the experiment may be present. These trends Include wear of tooling and equipment, leaming curves, change In temperatures, and so on, and the trends may show up as linear, quadratic, or even higher order trends. All previously published work has dealt with various methods of constructing trend-resistant run order plans on full and fractional factorial designs. These previous efforts have not addressed any additional dimensions in the trends that emerge when using hierarchical designs such as spIlt-piot plans. These designs are common in many manufacturing experiments where complete randomization is not possible or is too expensive to be practical. The objective of this work is to establish the foundations of a method for constructing linear and quadratic trend-resistant plans In two-level split-plot designs that addresses the two-dimensional trends that may occur. The methodology Involves development of a hybrid approach using the foldover method in each of the dimensions of Interest and embedding these in a nonlinear Integer programming model In the search for a feasible solution. Feasibility of this approach is shown for the particular case of a spilt-plot design (25 whole-plot factors and 3' x 2' split-plot factors) performed on abrasive machining. In this case study, an experimental plan that Is robust against all linear trends and most quadratic trends was achieved.
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Taxis are abundant and cheap and are a fast and easy way to get around the city. There are also rickshaws for hire as well. But these are good only for shorter distances. For the latter, its a good idea to bargain. Also, some are connected to one of the several local tour operators who will also try to sell you their tours.
Suzhou Railway Station
Suzhou has a new railway station. During my visit in 2010, the new building was started in operation with new ticketing machines, chairs, counters, and etc. This giant building was built with wooded like roof top, which is unique in China.
You can take the speed rails to/from Shanghai (30 minutes) and Nanjing (1 and half hours). It becomes an important and busy transportation hub in China.
In Chinese: 苏州站 (Su Zhou Zhan)
- Trains
Bus to Tongli
Getting to Tongli is relatively simple from Suzhou. Buses depart every 15 minutes or so from outside the train station (over on the left hand side as you look at the station). They cost about Y8 and take about 45 minutes. You can also purchase the Tongli entrance ticket on the bus for Y80 which saves you the cost of the bus fare.
On the way, you'll follow the Grand Canal and if you sit on the right hand side of the bus, you'll get the chance to see the 53 arches of the Tang dynasty Precious Belt Bridge which is located a few kilometres outside Suzhou.
The bus station in Tongli is on the main road. To get into the old part of Tongli simply follow the road back towards Suzhou for about 100 meters and then turn right and you'll see a big archway. This road then leads to the old town.
Train station
The train station is located in the north of the city. I took a train to Suzhou from the main railway station in Shanghai on the new Japanese bullet-train looking CRH trains which you should really try out as they are amazing. I then left Suzhou by train to go to Zhenjiang. Check out the website below for train times and destinations:
- Trains
Standing Train From Shanghai to Suzhou
I got the cheapest tickets for the train trip to Suzhou from Shanghai. My ticket was a standing train. On the way it cost 13yuan on then on the way back 15yuan.
The standing train was an adventure. Crowded beyond belief with people carrying giant bags and all sorts of other things. Add to that the train staff trying to get through to sell noodles and other snacks. It's cheap, but not my preferred means of travel, particularly seeing as though on the return leg I was up against the toilet door and I had to keep one hand on the door handle to stop it from openning and me from falling in as the train rocked. Stick, cramped and uncomfortable, I laughed it off and was sure to pay extra for a seat on my next train trip.
- Backpacking
- Trains
- Budget Travel
Train from Shanghai to Suzhou
It is very easy to get to Suzhou from Shanghai by train. Trains depart from Shanghai's main station hourly and the journey time varies between 35-50 minutes. Tickets cost RMB31 (that's GBP2 or USD4!) one-way for first class. Second class is even cheaper!
- Business Travel
- Budget Travel
- Romantic Travel and Honeymoons
Get to Suzhou by air
It may sound surprising but there is no Suzhou airport!
It's b/c Suzhou is only an hour ride from Shanghai and there are shuttle bus from both Shanghai airports to Suzhou. The bus departs from Pudong airport and will pick up more passages in Hongqiao airport before it heads to Suzhou. There are two stops in Suzhou, one stop is the Suzhou industry zone and the final stop is at Sanxiang Road in middle of Suzhou.
For more detailed information about bus time schedule:
This page seems only available in Chinese version. Currently, the bus departs from Pudong Airport at: 10:40, 11:20,11:50,12:50,13:50,14:40,15:20,16:10,16:50,17:50,18:50,19:40
The price is 82RMB.
- Budget Travel
- Backpacking
- Road Trip
Driving rather than bicycling
Used to be a lot of fun riding a bicycle around Suzhou. Crossing the bridges and stopping for a photo or two. But in my recent trip, the traffic is getting too heavy and would recommend being driven around in a hired car. Suzhou is still small enough to do part by foot by then there will be the annoyance of "tour guides for hire" if you are easily seen as tourist from a kilometer.
Day trip from Shanghai possible
Suzhou is close enough to Shanghai for a day trip from there.
There is no airport.
There is an excellent train service between Suzhou and Shanghai. The Shanghai Train Station can be reached easily by Shanghai metro train.
Another alternative is by road. However the highway and trunk road between Suzhou and Shanghai has been under reconstruction and was causing traffic delays. I have not been there this year but hopefully it has been mainly completed by now. Check the status - train is always an alternative.
Transport from Shanghai
Transport from Shanghai is convenient.
Go to the railway station and you can find a lot of trains going to stop at Suzhou. It usually takes an hour on a train to get to Suzhou. 10 yuan-30 yuan will be the fee.
You can also take highway bus shuttles and it should be a little faster. 30 yuan-50 yuan.
Bus from Shanghai Pu Dong
One of the easiest ways to get to Suzhou is by bus from Shanghai PuDong Airport. The following link details the routes and times.
Alternatively you can take the bus to the Shanghai Rail Station, and then take the express train to Suzhou
- Arts and Culture
- Historical Travel
- Business Travel
The wheels on the bus...
As in every city in China getting around by bus is an easy and one of the most favoured tansportations. And when i saw these cute bus stops, i just HAD to take a photo! Of course in Suzhou, you can also drive, ride bicycles of hop on a boat which will take you down the many canals....!
Canal Boat Suzhou-Hangzhou
Canal Boat to Suzhou is an interesting experience. I've once taken the boat in opposite direction, Suzhou-Hangzhou. However, I don't think the boats are suitable for travellers. The boats are chained in line, one after another, up to 4. The first one tugs the others. If take the leading boat, you must buy its 1st class ticket otherwise the cabins are besides the engine room so that you won't have a good rest. All the rooms are pretty small with no furnishments. 2nd class rooms are unacceptably small. The night view of the Canal is all in darkness. You must cherish the dawn and dusk. Well, I think the boats to Wuxi is a better choice. although it takes 1hr more time, the boats sails in Lake Taihu, the 3rd largest lake, for that period. So you can enjoy both canal and lake views. I won't revise your route, but suggest you take the Hangzhou-Wuxi boat. If you won't spend time on Wuxi, just take a train to Suzhou. Lots of trains run between the 2 cities and it takes only a half hour's time. Remember to book the boat tickets in advance or you'll have fewer choices.
Places to buy boat ticket/Wharf:
Hangzhou, 138 HuanchengBeiLu, (Wulinmen)
Suzhou, Renmin Qiao(People's Bridge)
Both are in downtown areas.
Rented Bicycle
Bicycle is cheap and give you more freedom in going where you need to go around Suzhou. Rental is about RMB10 for a day along Shiquen Jie, there are a few shop renting it. Before taking it, make sure the brakes and locks are working properly. You won't want the bicycle to be stolen. They sometime ask your passport or RMB500 or something as a deposit.
- Backpacking
- Budget Travel
Getting to Suzhou
It's quite easy to get to Suzhou from Shanghai by either bus or train. We took the bus there and train back, and the train does the 90km journey in less than 40 minutes to Shanghai station.
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Instant Answers: Suzhou
Get an instant answer from local experts and frequent travelers
- Great room rates
- Gloria Plaza Hotel Suzhou Suzhou
- Expedia.com
- Great room rates
- Shangri-La Hotel Suzhou Suzhou
- Booking.com
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Still Standing: Season 3, Episode 16
Still Not the One (14 Feb. 2005)
Ratings: 7.9/10 from 39 users
Reviews: write review
Louise and Johnny are getting married. They set the date in two weeks on Valentine's Day and she wants the family to take part. Lauren and Tina will be the bridesmaids, Brian will play the ... See full summary »
Director:Gerry Cohen
Stars:Mark Addy, Jami Gertz, Jennifer Irwin | See full cast and crew »


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Murderers' row? Rangers' projected starting lineup with Shin-Soo Choo
Photo: Ted S. Warren/AP
3B Adrian Beltre -- With the departures of Josh Hamilton, Mike Napoli and Michael Young following 2012 and the suspension of Nelson Cruz, Beltre was left to carry the offense for much of the year. His defense bears monitoring. He has now played the fourth most innings at third base in history and will be behind only Brooks Robinson and Graig Nettles by the end of April. As the wear and tear on his body continues, can he remain an elite-fielding third baseman?
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Spring has sprung! BBB is warning homeowners to be on the lookout for home improvement scams.
This is the time of year when less-than-reputable or unqualified contractors come into town promising a variety of services at cut-rate prices. They may show up at your door, advertise in local papers, or deliver fliers to your home.
There are thousands of reputable contractors who will deliver quality work, on time and within budget. Here are some tips from the BBB on how consumers can avoid costly mistakes and scams:
At least one poorly-conceived charity scam (this one was on Twitter) has already emerged in the wake of the explosions at the finish line of the Boston Marathon yesterday, and more are likely.
BBB Wise Giving Alliance ("Alliance"), the national charity monitoring arm of the Better Business Bureau, and BBB Serving Eastern Massachusetts, Maine, Rhode Island and Vermont ("BBB Boston") cautions donors about potential red flags concerning tragedy-related philanthropy.
Springtime is synonymous with spring scams. It never fails. Every year, around this time, scam artists come out of the woodwork. Scam artists will break down your door with "too good to be true" opportunities. BBB recommends you look out for these three spring scams:
SHEPHERDSVILLE – What comes first? The horse or the cart? Or is it the chicken before the egg?
SHEPHERDSVILLE – When Bullitt County Judge/Executive Melanie Roberts presents her 2013-14 budget to fiscal court members in early May, there will be a 50-cent per hour across-the-board increase proposed.
PIONEER VILLAGE – A piece of property bordered by two major roadways may soon become home to more commercial development.
PIONEER VILLAGE - Do you remember in being offered home economics or shop in high school?
SHEPHERDSVILLE – The state auditor's office has a large burden in making sure governmental agencies are audited each year.
SHEPHERDSVILLE - The decision for Shepherdsville city employee pay raises in January continues to draw ire from some residents.
LOUISVILLE – Seven Counties Services, Inc., the Louisville region's leading provider of behavioral health and developmental services, is seeking relief from the burden of unsustainable mandatory employer contribution rates imposed by the Kentucky Employees Retirement System (KERS).
Copyright © 2015
The Pioneer News Online is your source for local news, sports, events and information in Bullitt County and Shepherdsville, KY, and the surrounding area.


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Cable Show Convention and Exposition
Cable industry leaders talked about the future of media and telecommunications, focusing on how the cable industry will remain viable… read more
Cable industry leaders talked about the future of media and telecommunications, focusing on how the cable industry will remain viable players as consumers increasingly turned toward other platforms to view programming. They also talked about innovation in programming and delivery methods. close
People in this video
- Jeffrey L. Bewkes Chair and CEO Time Warner, Inc.
- Glenn A. Britt Chair and CEO Time Warner Cable
- Chase Carey President and Chief Operating Officer News Corporation
- Liz Claman Anchor FOX Business Network
- Philippe P. Dauman President and CEO Viacom, Inc.
- Patrick J. Esser President Cox Communications
- Neil Smit President Comcast
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Get the Facts
The Role of STD Detection and Treatment in HIV Prevention...link between STDs and HIV infection? How can STD treatment slow the spread of HIV infection? What are the implications for HIV prevention? Where can I get more information? References Testing and treatment of sexually transmitted diseases (STDs) can be an effective tool in preventing the spread of HIV , the virus that causes AIDS. An understanding of the relationship between STDs and HIV infection can help in the development...
Ask the Experts
Dr. Bob is Amazing!Dr. Bob I was tested at 5.5 months using Rapid test and 9.5 months using test which took a week to get results back. That is also negative! You sure do know your stuff!Thank you so much for what you're doing here on this site. I appreciate the fact...
Response from Robert J. Frascino, M.D.
The Robert James Frascino AIDS FoundationHi,Thanks for your thanks and kind comments. WOO-HOO!Regarding your "PS," mercury from fish and/or being exposed to random people on the subway would not delay seroconversion; however, being exposed to random fish on a subway to the planet Mercury... Read more »
Would having one sexually transmitted disease lower any possibility of resistance to HIV exposure or resistance to another STD?The Body: Rick Sowadsky M.S.P.H., C.D.S, Answers to Safe Sex QuestionsWould having one sexually transmitted disease lower any possibility of resistance to HIV exposure or resistance to another STD?
Response from Rick Sowadsky, M.P.H.
Nevada State Health Division AIDS Program...Hi. Thank you for your question. If a person has one Sexually TransmittedDisease (STD), they may have been exposed to others as well. That's why weoften recommend that if a person has been diagnosed with one STD, Read more »
Vasectomy and HIV/STD'sCan a male who is HIV Positive, who has a had a vasectomy, transmit HIV and other STD's during unprotected sex?
Response from Rick Sowadsky, M.P.H.
Nevada State Health Division AIDS Program...question. A vasectomy (a form of male sterilization to prevent pregnancy) will not prevent the transmission of HIV, nor other sexually transmitted diseases (STDs). So even if you had a vasectomy, you are still capable of transmitting HIV and... Read more »
Withdrawal method, STDs, and PregnancyCan a guy "pullout" before he ejaculates so it prevents you from getting STD's aids are getting pregnant?
Response from Rick Sowadsky, M.P.H.
Nevada State Health Division AIDS Program...you are talking about is known as the "withdrawal method". The withdrawal method will not provide adequate protection against Sexually Transmitted Diseases (STDs) including HIV, and you would still be at significant risk of infection! In... Read more »
Cook County, Ill., Ranks High in Sexually Transmitted Disease: STD Treatment Costs U.S. Health Care System $16.4 Billion a Year... New CDC figures show the United States logs 19 million new STD cases each year. Less than half the people who should be screened receive the recommended STD tests, CDC said. If left undiagnosed Read more »
How Do You Talk To Your Partners About HIV/AIDS and Other Sexually Transmitted Diseases (STDs)?...There is no easy answer concerning how to talk to a partner about HIV/AIDS and sexually transmitted diseases (STDs). Although many people find it easy tohave sex, they find it extremely difficult to talk about it. So how does onebegin? The Read more »
Sexually Transmitted Disease (STD) Diagnoses and Mental Health Disparities Among Women Who Have Sex With Women Screened at an Urban Community Health Center, Boston, Mass., 2007...have sex with men only (WSM)," the authors wrote. However, there is limited research on these indicators in conjunction with STDs and WSW sexual health. From July to December 2007, a retrospective chart review was performed on all female... Read more »
Sexually Transmitted Diseases (STDs) -- Overview... What Is a Sexually Transmitted Disease (STD)? How Many People Have STDs? How Do You Get an STD? What Are the Symptoms of STDs? How Do You Get Tested for STDs? Read more »
Connect With Others
Protected sex!!!! It's making me crazy
Posted by Anonymous, 5 RepliesOk, someone explain WHY people are worried about protected sex? If you had protected sex and are worried about getting HIV, then you have major guilt issues with your behavior. So, keep in mind always, protected sex is just that PROTECTED, so stop... Read more »
4 yrs ago
Posted by lovemestill07, 4 RepliesHi, About 4 yrs ago I had unprotected vaginal sex, which only lasted a few minutes with someone I had just started dating (stupidest mistake I've ever made). About a week after we had sex I got very sick for one day (fever, severe headache,... Read more »
Check for other sexually transmitted diseases too
Posted by Anonymous...How to get the standard STD clinic tests when you go and get tested for AIDS HIV : Ask the doctor or clinician to check for throat, for urethral, for anal Read more »
Posted by dsaklad, 1 Reply...When getting tested it's a good idea to get tested for a. sexually transmitted diseases, ... Read more »
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Afternoon Delight, is, not surprisingly, a rip roaring afternoon book discussion, meeting at 1 p.m. on the 3rd Thursday of every month. To be placed on the waiting list for this book club, contact either C. Bellessis or Pam Kepler. The list of what we've read so far in 2015 may be accessed here.
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