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Like Elaine.
Yes I love dancing, no matter what the speed I like fast but I love slow.
YES, but I only dance two speeds, slow and SLOWER.
I have two left feet.
I have not been professionally trained, but I love dancing...usually when I am alone.
hecks yeah I throw down :] Im gonna have a dance party and your invited yay
I love that movie! that twilight chick was hot, and applause to dakota fanning for doing blow in a plane bathroom.
like john travolta baby
ah...ah....ah...ah..stayin' alive
Yup. Trained as one when I was a kid... Girls got rhythm ...
2 left feet actually
LOL nope but it's fun anyway
as long as I have good music yes.
I can bust a move.
break dance yes , ball dance no , ballet no luck
it really fun and take lot of practice you should try it
Ha. Well technically yes,.... Just not in a way that is pleasing to the eyes of those around me.
In the sense that I do something I call dancing, yes. But in terms of talent, I have none whatsoever.
Ha, can I dance? No..
Even if I could, I wouldn't want to :P
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Hepcidin induces HIV-1 transcription inhibited by ferroportin
1 Center for Sickle Cell Disease, Department of Medicine, Howard University, Washington DC 20060, USA
2 Department of Microbiology, Howard University, Washington DC 20060, USA
3 National Center for Biodefense and Infectious Diseases, George Mason University, 10900 University Blvd, Manassas, VA 20110, USA
Retrovirology 2010, 7:104 doi:10.1186/1742-4690-7-104Published: 2 December 2010
Physiological regulation of cellular iron involves iron export by the membrane protein, ferroportin, the expression of which is induced by iron and negatively modulated by hepcidin. We previously showed that iron chelation is associated with decreased HIV-1 transcription. We hypothesized that increased iron export by ferroportin might be associated with decreased HIV-1 transcription, and degradation of ferroportin by hepcidin might in turn induce HIV-1 transcription and replication. Here, we analyzed the effect of ferroportin and hepcidin on HIV-1 transcription.
Expression of ferroportin was associated with reduced HIV-1 transcription in 293T cells and addition of hepcidin to ferroportin-expressing cells counteracted this effect. Furthermore, exposure of promonocytic THP-1 cells to hepcidin was associated with decreased ferroportin expression, increased intracellular iron and induction of reporter luciferase gene expression. Finally, exposure of human primary macrophages and CD4+ T cells to hepcidin and iron was also associated with induction of viral production.
Our results suggest that the interplay between ferroportin-mediated iron export and hepcidin-mediated degradation of ferroportin might play a role in the regulation of HIV-1 transcription and may be important for understanding of HIV-1 pathogenesis.

subset: commoncrawl


text:
November 30, 2015
Stacy Fleming, 23, second from left, hugs her friend Pam Frakes Monday, July 23, 2012, at a make shift memorial that the public created across the street from the Century Theater where a mass shooting occurred last Friday killing 12 and injuring dozens of others in Aurora, Colo. (AP Photo/Barry Gutierrez)
Family members of some of the 12 people shot to death during a midnight movie showing in Colorado are speaking out about some behind-the-scenes events they say need to be aired publicly.
They have scheduled a news conference for late Tuesday morning.
A spokeswoman for the group declined to comment on what the families would talk about.
A gunman wearing body armor and a gas mask opened fire on July 20 in a packed theater in the Denver suburb of Aurora during a showing of a Batman movie.
In addition to the 12 killed, 58 were injured.
The 24-year-old suspect, James Eagan Holmes, faces charges of murder and attempted murder. He's being held without bail and hasn't entered a plea.
Defense lawyers have said Holmes is mentally ill.
Click Here to access the online Public Inspection File
Viewers with disabilities can get assistance accessing this station's FCC Public Inspection File by contacting the station with the information listed below. Questions or concerns relating to the accessibility of the FCC's online public file system should be directed to the FCC at 888-225-5322, 888-835-5322 (TTY), or email@example.com.


text:
Comments by ILoveSlexie
I don't see mark befriending the guy that's sleeping with the love of his life. Teaching him ,yes. becoming his friend, no. But as i know it Avery working with Sloan is only so this triangle can continue, a lame plot point, when i rather see Lexie go into plastics working side by side mark. I need for them to get back together, They are my only OTP of this show, i like MerDer but not enough to continue watching if M/L don't get back together, this is why i'm sick and tired of SR messing with our fan-base all in the name for ratings. She needs to just put them back together and stop lying to the M/L fans and giving us "Yes it's going to happen" Which it never dose. or "you have 87%" Enough,already. Mark and lexie have been through more then all the couples combined. It's time for some pay off and i would love nothing more then for this "New" season to end with M/L Engaged or married.
Also i'm so glad that the writers aren't having mark fight for lexie, He's already done all the fighting he could to get her back and it didn't work. Hopefully, Lexie see's him trying to move on and starts to fight for him this time around. She needs to prove to him that she really wants him back this time and with everything he is offering. I just hope we get our candle moment this season. We need it badly after Season 6/7
Lexie and mark need to get back together already, this has gone on long enough by SR and Co. I want a Slexie wedding at the end of Season 8 just in case MerDer actually do leave. I don't think the age Difference has anything to do with anything. Lexie's not in her early twenties she almost thirty, She needs growth and i guess that's what going to happen in Season 8? Hopefully, because i want my only OTP on this show to get together and stay together. Also on the whole lexie to young to become a step mother, No. I know people who are a lot younger then her and making a career for themselves. @smileyglen - In her Twenties? She almost thirty, that's the time people start to settle down, not go out and party. Lexie needs to grow up and marry this man, not start sleeping with another roommates when she gets hurt again, How's going to be next? She ran out of guys in that house. i think lexie still see's herself as a teenage, because she certainly doesn't act like an adult. I mean seriously sleeping with two people you live with ? She needs to stop doing that.
@Lucia - From the article online he was already out of rehab before anything got leaked about him being in rehab, plus it said his schedule wouldn't be effected. IDK @tinnie - That is Chyler/Lexie ... She just has a different hair style
Jaxie, still? when is lexie going to get out of Jackson hell. do these writers think if they push Jackson's useless character enough on Lexie that i'm going to like him better, it's actually the opposite .... Stop forcing Jackson/Jaxie down our throats. They are the worst couple besides Gizzy that was ever paired together. also ... WTH is mark? Poor Meredith, She looks so lost and Derek i feel bad for him also, i just hope these writers don't make it seem like Zola's the only reason they are getting back together. Cristina Seriously hitting Alex? WTH is wrong with her.
These writers are going to redo everything that MerDer has already been through. Hell, they've been doing that since Slexie got together in the first place. I don't understand why, Mark and Lexie are nothing like MerDer, nothing and yet writers, fans and anyone else are comparing the two. But yes i want to see Mark/Lexie marry (Would love to see Lexie pregnant) and MerDer have there baby, C/A they got everything already .... Jackson/April can leave and Alex can go back to wherever Izzie is and find her. then end the show and be done with it.
Ok thanks GAfan. I do hope we are getting Slexie, I really do. SR Tweeted to us fans about having 87% chance of getting them back. I just don't understand the percentage
Abc already said this show isn't ending, SR already stated this show isn't ending ... but to some the show is ending? LOL ... Lexie nor anyone else needs to be leads, Meredith isn't even a lead anymore at least she doesn't get the airtime or story regular leads get. But if they want to make Lexie, Mark and Slexie Leads it is what it is. I actually wouldn't mind so much as long as the couple is together. But again this show can go on without leads. DH is ending because it's just not a good show anymore, hasn't been one in a good couple of years IMO. but grey's could be good, Great, again if the writers would actually write Story-lines instead of PP. Maybe Grey needs fresh writers IHDK
@GAFan - Where did you hear that from ? It actually doesn't shock me in the least ... this is what this show has been doing since middle of season 6 it's on and off with this couple and showing no growth at all. Mark and lexie should have stayed together through this whole last season after they got back together episode 10, but of course not, that would actually make Slexie the Story and not lets crap on mark again story line that she had in season 6 .... I hope that article is right and if it is, i'm sure it's abc hand and not SR that going to make our couple happen ... I just don't think she wants ML and the one person that did in the writers room has left.... I feel like the closest we'll get to Slexie happy is by reading fan fiction
Also: It's sad that mark and lexie would have been together four years now have they not had any 3rd parties (Callie,long lost daughter, baby drama, Jackson, Alex; lets not forget a shocking only not SoS Pregnancy)but instead every other and i mean even teddy gets to get married and start family's. while mark gets to be alone for a whole season and lexie hops into the next available bed (not 3 months after, though felt like 2 minutes) she can find. How is this even interesting when we've seen this story play out the same way last year? It's just so sad and depressing that a soap couple can get together sooner than a prime time couple and soap couples are all about the back/fourth, well they, wont they. Yearning.


text: NTSB Confirms Jenni Rivera Died in Plane Crash Her driver's license found among wreckage By Newser Editors and Wire Services Posted Dec 10, 2012 10:36 AM CST STORY COMMENTS (17) (Newser) – The US National Transportation Safety Board is confirming that Mexican singer Jenni Rivera was indeed killed, along with six other people, in the Learjet crash early yesterday in Monterrey's mountains. "It was Jenni's plane that crashed and that everyone on board died," her father, Pedro Rivera, told dozens of reporters gathered in front of his Los Angeles-area home. "I believe my daughter's body is unrecognizable." It is the first official confirmation of Rivera's death, although she has been widely presumed dead since the wreckage of her plane was found yesterday. The NTSB is sending a team to assist Mexican authorities with the investigation. An NTSB spokesman says Mexican aviation authorities had confirmed Rivera's death to the NTSB. Jenny Guerrero pays tribute to Jenni Rivera at a makeshift memorial in front of an image of the Virgin of Guadalupe at the Plaza Mexico shopping center in Lynwood, Calif., early Monday, Dec. 10, 2012. (Patrick T. Fallon) (J. Magno) This April 25, 2012 photo shows Latin singer Jenni Rivera rehearsing for the 2012 Billboard Latin Music Awards, in Coral Gables, Fla. (Gary I Rothstein) In this picture taken March 8, 2012, Mexican-American singer and reality TV star Jenni Rivera poses during an interview in Los Angeles. (Reed Saxon) Jenicka Lopez, 15, daughter of Jenni Rivera, right, is hugged by Rivera's niece, Divine Rivera, outside the home of Jenni Rivera's father in Lakewood, Calif., on Sunday, Dec. 9, 2012. (Patrick T. Fallon) A woman adjusts a flower in front of candles and pictures displayed in tribute to singer Jenni Rivera at the Plaza Mexico shopping center in Lynwood, Calif., early Monday, Dec. 10, 2012. (Patrick T. Fallon) A California driver's license bearing the name of Jenni Rivera at the site where a plane carrying Rivera crashed near Iturbide, Mexico, Sunday, Dec. 9, 2012. (STR) ADVERTISEMENT(Click Prev or Next to continue viewing images.) « Prev« Prev | Next »Next » Slideshow Associated Press (Source Grid ») World • Celebrity Mexico • plane crash • NTSB • National Transportation Safety Board • Monterrey, Mexico • Jenni Rivera CLICK BELOW TO VOTE 2% 6% 0% 87% 3% 2% RETURN TO THE STORY To report an error on this story, notify our editors.


text: Training UCAR requires that you complete training before you can work with animals in the laboratory and/or gain access to the Vivarium. Anyone who enters the vivarium must complete all UCAR required trainining and must be added to a UCAR protocol. Animal Resource Orientation Facility Tour (SMD, KMRB, CVRI, or Primate Tour) CITI Online Training: Investigators, Staff, and Students –Working with an IACUC Aseptic Surgery (if performing recovery surgery) Species-Specific Training (e.g., mouse, rat, gerbil, rabbit, etc.) Blackboard Training: MicroIsolator Technology and hands-on Rodent Colony Management Rodent Euthanasia Rodent Recovery Surgery Workshop is required for all new hires that will peform recovery surgery on mice and rats. Contact firstname.lastname@example.com for additional information on this course. Basic rodent handling workshops are required for all new hires that will work with rodents. Contact firstname.lastname@example.com for additional information on this course. Complete the online modification form. Important Notes: If working with chickens and ferrets, review the DVD or CD available in the UCAR Office. Return the training media and remember to submit the completed training documentation form to UCAR. If working with monkeys, complete the CITI online training and the Primate Safety Training (available in the UCAR Office). Return the training media and submit the completed quiz to UCAR. Contact DLAM (585) 275-2653 to schedule a Primate Tour. CVRI Tours are scheduled after all UCAR training has been completed. Environmental Health and Safety Training Online tutorial: Environmental Health and Safety Industrial Hygiene Unit Safety Training (if working in a laboratory) OLAW Training OLAW Training (Web videos) Working Safely with Non-Human Primates Working with the Laboratory Dog Training in Survival Rodent Surgery


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WASHINGTON – It's baaaack.
Once again, the McDonald's McRib sandwich has returned. While it officially retired in the 1980s and again in the 1990s, the rectangular sandwich on the oval bun has managed to creep back into the mouths of McDonald's enthusiasts everywhere, almost every year.
Recently, the Golden Arches caught some flack after a photo of a flat, frozen and grayed McRib made it to Reddit. The decidedly unappetizing patty riled up fans as the you-weren't-supposed-to-see-that picture quickly reached viral status.
In an email to The Huffington Post, a McDonald's spokesman defended the food by saying, "just like a burger patty is formed to be round and flat, we form the iconic McRib in the shape of traditional ribs. We then flash freeze the patty to seal in flavor and freshness, just like you freeze meat in your own freezer, before going to our restaurants."
Naturally, that just added to the rabble rousing and some news organizations began analyzing the dear, sweet McRib.
McDonald's lists "boneless pork" as the McRib's main ingredient – interesting for a sandwich named after a bone. But, the Atlantic reports, the type of pork traditionally used for this pressed meat dish is tripe, heart and stomach material.
But, with nearly 500 calories and more than 30 percent daily value of sodium, the McRib will stick to your ribs, even if it's never been anywhere near a rib.
McDonalds has the full nutrition details.
Follow @WTOP on Twitter.
A look at the winter weather news in the D.C. area.
For a trip to the North Pole, there's no finer way to travel. Railroads around the country offer seasonal trips to see Santa between Thanksgiving and Christmas.


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Show Events
Liverpool goalkeeper Simon Mignolet insists nobody at Liverpool, especially Steven Gerrard, is daring to dream about a fairytale FA Cup Final.
Read more >
Joe Cole has his sights set on adding to his impressive tally of medals and says with his team just two wins away from glory, anything is possible.
When Gareth McCleary steps out against Arsenal at Wembley he will be playing not just for Reading, but the thousands of non-league players who have contributed to this year's FA Cup.
Sixty-four football fans will form an 'FA Cup Fans choir' and sing Abide With Me prior to this season's FA Cup Final at Wembley Stadium connected by EE.
© 2001-2015
Wembley National Stadium Ltd, Registered Address: Wembley Stadium, Wembley, London HA9 0WS Registered in England No. 3388437
Follow us for latest news and event updates


text:
Quiz on Immunology
A quiz on the immune system of your body. It is simple and very interesting. Lets see how much do you know about your body.
Immunology is the branch of science that deals with immune system of our body. Immune system is very important for our body as it protects us from pathogens and toxic compounds.
So, below is an interesting quiz for all of us to know about our immune system.
1) Which cells provide cell-mediated immunity?
Ans. T cells
2) Which cells produce antibody?
Ans. B cells
3) Which cells prevent penetration of microbe into body through skin?
Ans. Epithelial cells
4) Which type of immunoglobulin antibodies are?
Ans. Gamma
5) Which cells are phagocytes and called as microglial cells in brain?
Ans. Macrophages
6) Which component of serum can agglutinate bacteria?
Ans. Agglutinin
7) Which types of antibodies does Hybridoma Technology produce?
Ans. Monoclonal antibodies
8) Which human infectious disease eradicated from the world in 1970's?
Ans. Smallpox
9) Which clotting factor is absent in Hemophilia A?
Ans. Factor VIII
Image via Wikipedia
10) Which branch of biology deals with the immune system of our body?
Ans. Immunology
For more related and interesting quizzes refer:
- Funny Biotechnology Quiz: Click it to find an innovative way to learn and laugh biotechnology.
- Funny Biotechnology Quiz Two: Click it to find an innovative way to learn and laugh biotechnology. A quiz specially meant for Non-biotechnologist to try their hands on biotechnology.
- Quiz on Biotechnology: A general quiz on biotechnology.
- Quiz on Biotechnology: Part 2: A wonderful quiz to enhance and check your knowledge on the topic of biotechnology. It is back with a bang.
- Mystery Quiz in Immunology #1: Read the clue and find the answer. One clue is already given in the title. For rest clues come in.
- Quiz on Immunology: A quiz on the immune system of your body. It is simple and very interesting. Lets see how much do you know about your body.
- General Biochemistry: A quiz on the most important field of biotechnology.
Liked it


text:
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Good point Progeo. If 106 is good, I think we will regain a lot of original excitment, if only for the probability that the attractiveness of a take out is enhanced.


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Press Release Distribution
Filter NewsShow All Results
News By Country
News By TagFog
fog Press Releases+ XML/RSS
By Teledyne TSS
Teledyne TSS is launching the latest addition to its Saturn product range at the Ocean Business exhibition with the introduction of its fibre-optic marine gyrocompass.
By Eco-Drain System
Eco-Drain System™ recently launched Eco-Gelly™, a 100% all-natural bacteria compound that addresses the root cause of fruit flies in commercial kitchens – fats, oils and grease (FOG) in drains.
By Norman Moody Engineering
NME releases a new web site aimed at the owners of commercial food outlets. Detailing the production of stainless steel grease traps which enable companies to comply with legal requirements in Northern Ireland and the Republic of Ireland.
By Make Hang Gallery
What: An exhibition and weaving class - Air Warp: Swing and Weave When: March 15th, 4-7 pm & March 30th, 6-9pm, & by appointment Where: Make Hang Gallery, 450 Green Street in North Beach, SF Free: Everyone welcome
By Carol Tunick
Wilks InfraCal TOG/TPH Analyzers provide accurate, on-site analysis to help regulators and industry reduce the discharge of fats, oil and grease in wastewater. They provide on-site results in 10 minutes and are easy to use by non-technical personal.
By Musicorp
MBT Lighting, a leading source of disco, DJ lights, special effects and stage lighting for DJs, nightclubs, bands, theaters, churches and schools is excited to announce a promotional product rebate for a free fog machine!
By Carol Tunick - Wilks Enterprise, Inc.
Emulsion-breaking methods to ensure accurate oil in water measurements are discussed in White Paper published by Wilks. Certain water samples may form an emulsion when oil in water extraction into a solvent is done affecting measurement accuracy.
By SnowMasters Special Effects
Clubs, theatres, bands, entertainers, amusement and theme parks, business speakers, sporting events and more are utilizing the latest in a dazzling and interactive special effects technology called cryogenics.
By 4 C M
Conference to be held at Cranfield University on the 24th March addressing the problems of fats, oils and greases
By Matt McKee
Kids set up Haunted Halloween display in Dedham neighborhood. Open to the public.
By Eloquent Books
In Mark Wilson's new book The Legend of Crawley Creek, a strange fog transports two young brothers back in time to a mysterious world where time seems to stand still.
Page updated every 10 minutes


text:
May 15, 2013 |
Comments (0) | Post a comment
Please fill out the form below to send a link to this story to your colleagues.
LITTLETON, Colo. — Norgren, a global supplier of motion and fluid control solutions, has engineered air intake throttles specifically for heavy-duty diesel engines in commercial vehicles.
Officials said the air intake throttle stands up to the demands of heavy-duty diesel engines while precisely regulating airflow so that emissions control systems operate at peak efficiency. Common techniques for reducing nitrogen oxides and particulate matter or soot to meet 2013 EPA Tier IV Final Emissions Regulations include exhaust gas recirculation (EGR), selective catalytic reduction (SCR) and diesel particulate filters (DPF). Managing airflow optimizes EGR, SCR and soot filter performance.When these three are used in combination, managing the airflow is essential for boosting the EGR while maintaining high exhaust temperatures for maximum SCR and DPF efficiency, according to the company.The corrosion-resistant design of the air intake throttle incorporates FKM seals; high temperature-range greases; steel gears; pressure die-cast housings and a durable brushless electric geared motor. The machined flap meets tight tolerances inside the bore for precise sealing and is spring loaded to default to the open position as a failsafe. The brushless motor withstands vibration and high temperature to retain precision over millions of cycles.
The compact unit is available in multiple sizes to fit virtually any commercial vehicle design.
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Compressor mount system designed to cut maintenance, life cycle cost
Zonar, NAPT honor Don Carnahan Memorial Grant winners
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text:
For Patients & Their Families
Where can I find a list of clinical trials that are being conducted at Loma Linda University?
The Clinical Trial Center (CTC) can help you search for clinical trials currently accepting patients at Loma Linda University.
Who do I contact if I have a question or concern about a clinical trial?
Call Patient Relations at (909) 558-4647 or email email@example.com. You may also submit a Reporting Form for Research Concerns or Grievances.
Other Helpful Links & Resources
- CTC's page For Research Volunteers and Their Families
- CTC's Helpful Links & FAQs page


text:
|Abstracts on Global Climate Change
Jul 2005
A regional, multi-sectoral and integrated assessment of the impacts of climate and socio-economic change in the UK
Holman, IP Rounsevell, MDA Shackley, S Harrison, PA Nicholls, RJ Berry, PM Audsley, E
Policy makers and stakeholders are increasingly demanding impact assessments which produce policy-relevant guidance on the local impacts of global climate change. The 'Regional Climate Change Impact and Response Studies in East Anglia and North West England' (RegIS) study developed a methodology for stakeholder-led, regional climate change impact assessment that explicitly evaluated local and regional (sub-national) scale impacts and adaptation options, and cross-sectoral interactions between four major sectors driving landscape change (agriculture, biodiversity, coasts and floodplains and water resources). The 'Drivers-Pressure-State-Impact-Response' (DPSIR) approach provided a structure for linking the modelling and scenario techniques. A 5 x 5 km grid was chosen for numerical modelling input (climate and socio-economic scenarios) and output, as a compromise between the climate scenario resolution (10 x 10 km) and the detailed spatial resolution output desired by stakeholders. Fundamental methodological issues have been raised by RegIS which reflect the difficulty of multi-sectoral modelling studies at local scales. In particular, the role of scenarios, error propagation in linked models, model validity, transparency and transportability as well as the use of integrated assessment to evaluate adaptation options to climate change are examined. Integrated assessments will provide new insights which will compliment those derived by more detailed sectoral assessments.


text:
The collection of ready-to-wear outfits and accessories, mostly in joyful pastels, is bringing back the 50s, and filled with the happy taste of Spring!
To see Prada ready to wear S/S 2012 for men click on the picture below
I love this post, although I'm dying to see these bags up close and personal, this was the next best thing!
xo Mary Jo


text:
Thank this author by sharing:
By Steve Jones,
Hiring good people is hard, though in some cases it might not matter as much as others. If I am hiring entry level developers or DBAs, I have a lot of candidates, I'm not investing a lot, and I shouldn't be too concerned if I have to let someone go and find a new employee. Given the fact that the people are often unproven in this case by definition (they're junior levels), I should be prepared as a manager to make more mistakes at this level.
However at the senior level, hiring needs to be done more carefully. The high costs, the limited number of candidates, the responsibilities I give senior people, along with the trust I need to bestow upon them means that I can't afford to make the same percentage of mistakes at the senior level. Most importantly, I don't want to hire expert beginners instead of experts at this level.
I ran across a post on a way to hire senior developers that I thought was very interesting. In particular, I was struck by the analogy of hiring a guitar player. For the most part, I'd agree that if I wanted an experienced guitar player, I'd want the expert, not the expert beginner. If for no other reason than I don't want to argue with an employee that does things my way, including making the same mistakes I'd make, and then explaining to me this is how I had specified things to be. I want a senior people to warn me, and influence me to do better.
I'm not sure how I'd devise a similar level of test for a senior level DBA, though I do like the idea of giving them some scenario or simulation that has flaws or problems and seeing if they'd correct them, point them out, or leave them in place as they moved on to "play" the scenario. I'm sure there's a way to do this, and a balance between how to evaluate the responses.
Ultimately I want senior people to fix things, make them better, and provide a smooth path to increase quality. I want them to point out flaws, and warn me about issues. If I insist on making poor choices, I want their support, but if they can influence me to do better, I'd prefer they did. That's one mark of a senior person.
Last week I polled you on Junior DBAs and what was a good set of skills they should have. It did...
How can you justify your title as a Senior DBA
Hi all,
Our company has been looking for a Senior level SQL Server DBA, and the last (2) candidat...
A guest editorial from Andy Warren. Experience helps us do a better job, and one way you can get tha...
Senior level SQL DBA
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of articles and SQL scripts, a library of free eBooks, a weekly database news roundup,
a great Q & A platform… And it's our huge, buzzing community of SQL Server Professionals
that makes it such a success.
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Steve Jones
Editor, SQLServerCentral.com


text:
Caption This! Made In China For Harper's Bazaar China, By Shxpir
Winning Caption
"Her attempt to revive the art of planking failed miserably."
— Sommer Naffz
"You break, you buy."
— Nikki Peglow
See the rest of the entries here.
Check out today's caption contest!
Photo: Courtesy of Harper's Bazaar China.


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Gong Xi Fa Cai Wishes, Meaning, Greetings 2014
Looking for Gong Xi Fa Cai Wishes, Meaning, Greetings 2014 then here you will got a huge collection of this festival. Gong Xi Fa Cai is a Chinese word let me tell you the meaning of that world as Gong Xi means Congratulations, Fa Cai means become prosperous so the whole meaning is congratulations to you and you become prosperous on this new year. As the Chinese first year of new year is a day of Dragon so all Chinese celebrate this day with full of happiness. That day is a holiday in whole china and dragon is a sign of happiness so when the new year starts with happiness the whole year it will be good for them. There is big ceremony take place in China every year all the Chinese from all over the world come to china just to attend this ceremony. Chinese exchange good wishes with each other on that day that is why we are providing you some words so that if you go for wishing other then you not ran out of words have a look down there on the huge collection.
Gong Xi Fa Cai Wishes, Meaning, Greetings 2014
- g?ng x? f? cái — Congratulations and Prosperity
- Q?ng ji?shòu w? chéngzhì de x?nnián zhùfú, shùn zhù sh?nt? jiànk?ng — Please accept my sincere wishes for the New Year and I hope you will continue to enjoy good health.
- Zhùfú nín, x?nnián kuàilè — Season's greetings and best wishes for the New Year.
- G?nghèx?nx?, zhù sh?nt? jiànk?ng, shìyè f?dá — Allow me to congratulate you on the arrival of the New Year and to extend to you all my best wishes for your perfect health and lasting prosperity.
- G?nghèx?nx?, wànshìrúyì — Best wishes for the holidays and happiness throughout the New Year
- Zhù h?oyùn, jiànk?ng, ji?yáo bàn n? dùguò y? gè kuàilè x?nnián — Good luck, good health, good cheer and pass an happy New Year.
- Yuàn y?qiè zuì m??ih?o de zhùfú d?u néng yòng zhè zh?ng hèk? bi?odá, zh?nchéng dì zhù n? xìngfú, kuàilè, chéngg?ng! — May everything beautiful and best be condensed into this card. I sincerely wish you happiness, cheerfulness and success
- nián nián y?u yú — Wishing you prosperity every year.
- The Old Year has gone….
Let the dead past bury its own dead….
The New Year….has taken possession…of the clock of time.
All ail the duties & possibilities…of the coming 12 months.
- New Year is the time 2.
unfold new horizons & realize new dreams,
2 rediscover the strength & faith within u,
2 rejoice in simple pleasures &
gear up 4 a new challenges.
Wishing u a truly fulfilling 2013.
- Lets…welcome the year which is fresh and new,
Lets…cherish each moment it beholds,
Lets…celebrate this blissful New year.
We hope that you will like these Gong Xi Fa Cai Wishes, Meaning, Greetings 2014 as these are specially collected for you from different sources and looking forward for your response.


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Very friendly and helpfull staff, but simple (below standard) breakfast. Location is downtown and very central located, but somewhat noisy with cars passing and people shouting in the streets during the daytime. At night it is OK. All rooms have A/C and basic bathroom.
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- Tripoli Four Seasons


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- Overview
- Specs
- Reviews
TransIt 50 WedgePerfect for stashing a few tools, spare tube, patch kit, energy bar, phone, I.D. cards and keys, the TransIt 50 bike wedge with water resistance keeps all your essential items protected and secure. Tail light strap and reflective piping enhance visibility in low-light riding conditions.
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TransIt 50 Wedge
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- rating:
- 4
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Hi Angela,
Every thing was so wonderful. You exceeded our expectations in everything, from the moment we have arrived we started WOWing. We could not believe how big our room was, you should of seen us dancing around it! Our cocktail class was really good, Peter is a good mentor, he set our Party Mood to a perfect start. Dinner was good, the open desert bar was really tempting… we could not believe all the different selection of cakes & fruit salads.
You were right about the festive mood of the place. Both of the live performing bands were so good, people around so nice, the night just flew… We all had a great time! All the staff were so nice to us, I want to say thank you to everyone, to the girls at the reception and in restaurant, to all the bar staff, to security guys… And of course to you Angela, thank you so much, you really made our night memorable. I would not change anything… To all of the staff in Abbey hotel, have a Great Christmas and a Happy New year! I would definitely visit you again.
Hi Angela,


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|Date added:
|September 14, 2012
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Draft genome of the mountain pine beetle, Dendroctonus ponderosae Hopkins, a major forest pest
Author affiliations
1 Michael Smith Laboratories, University of British Columbia, 301-2185 East Mall, Vancouver, BC, Canada V6T 1A4
2 Canada's Michael Smith Genome Sciences Centre, 570 W 7th Ave #100 Vancouver, BC, Canada V5Z 4S6
3 Department of Biological Sciences, CW 405, Biological Sciences Bldg., University of Alberta, Edmonton, AB, Canada T6G 2E9
4 Ecosystem Science and Management Program, University of Northern British Columbia, 3333 University Way, Prince George, BC, Canada V2N 4Z9
5 Department of Medical Genetics, University of British Columbia, University of British Columbia, 4500 Oak St., Vancouver, BC, Canada V6H 3N1
6 Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, Canada V5A 1S6
Citation and License
Genome Biology 2013, 14:R27 doi:10.1186/gb-2013-14-3-r27Published: 27 March 2013
The mountain pine beetle, Dendroctonus ponderosae Hopkins, is the most serious insect pest of western North American pine forests. A recent outbreak destroyed more than 15 million hectares of pine forests, with major environmental effects on forest health, and economic effects on the forest industry. The outbreak has in part been driven by climate change, and will contribute to increased carbon emissions through decaying forests.
We developed a genome sequence resource for the mountain pine beetle to better understand the unique aspects of this insect's biology. A draft de novo genome sequence was assembled from paired-end, short-read sequences from an individual field-collected male pupa, and scaffolded using mate-paired, short-read genomic sequences from pooled field-collected pupae, paired-end short-insert whole-transcriptome shotgun sequencing reads of mRNA from adult beetle tissues, and paired-end Sanger EST sequences from various life stages. We describe the cytochrome P450, glutathione S-transferase, and plant cell wall-degrading enzyme gene families important to the survival of the mountain pine beetle in its harsh and nutrient-poor host environment, and examine genome-wide single-nucleotide polymorphism variation. A horizontally transferred bacterial sucrose-6-phosphate hydrolase was evident in the genome, and its tissue-specific transcription suggests a functional role for this beetle.
Despite Coleoptera being the largest insect order with over 400,000 described species, including many agricultural and forest pest species, this is only the second genome sequence reported in Coleoptera, and will provide an important resource for the Curculionoidea and other insects.


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Home / LSA Students / Academics & Requirements / Faculty /
Chemistry Faculty listing
Philip C. Andrews, Biological Chemistry, Bioanalytical Chemistry, Bioinorganic Chemistry, Chemical Biology
Mark M. Banaszak Holl, Synthetic and Mechanistic Solution, Surface, and Solid State Chemistry
Charles L. Brooks III (Warner-Lambert/Parke-Davis Professor of Chemistry and Biophysics), Molecular Chemistry
Heather A. Carlson, Computational Chemistry and Theoretical Biophysics
Zhan Chen, Biomaterial and polymer surface, biocompatibility
Mary Sue Coleman (President of the University of Michigan)
Brian P. Coppola (Arthur F. Thurnau Professor), Organic chemistry, Chemical Education
Carol A. Fierke (Jerome and Isabella Karle Distinguished University Professor of Chemistry), Biological Chemistry
Anthony H. Francis (Arthur F. Thurnau Professor), Magnetic Resonance, Vibrational and Electronic Spectroscopy of Solids
Eitan Geva, Theoretical and Computational chemistry
Gary D. Glick (Werner E. Bachmann Professor of Chemistry), Bioorganic Chemistry, Molecular Recognition
Theodore Goodson III (Richard Barry Bernstein Collegiate Professor of Chemistry), Physical Chemistry
Kristina Hakansson (Dow Corning Assistant Professor), Analytical Chemistry; State-of-the-art mass spectrometric techniques
Robert T. Kennedy (Hobart H. Willard Distinguished University Professor of Chemistry), Analytical Chemistry, Chemical Biology, Bioanalytical Chemistry, Chemical Separations, Mass Spectrometry
Jinsang Kim (Materials Science & Engineering), molecular design, synthesis, modification, and self-assembly of smart polymers for biomedical and optoelectronic applications
Raoul Kopelman (Kasimir Fajans Professor of Chemistry, Physics, & Applied Physics; Richard Smalley Distinguished University Professor of Chemistry), Analytical/Biophysical/Materials Chemistry Laser Spectroscopy, Nano-Imaging and Fiber Optic Chemical Nano-Sensors; Molecular Optics; Fractal Reaction Kinetics
David Lubman, Biological Mass Spectrometry, Spectroscopy and Instrumentation
Anna K. Mapp (Edwin Vedejs Collegiate Professor of Chemistry), Organic chemistry, chemical biology, new synthetic methods
E. Neil G. Marsh, Enzymes: structure mechanism and specificity; protein engineering and molecular recognition
Adam J. Matzger (Charles G. Overberger Collegiate Professor of Chemistry), Organic, polymers/organic materials
Anne J. McNeil (Arthur F. Thurnau Professor), Polymer Chemistry, Organic/Materials Chemistry
Mark E. Meyerhoff (Philip J. Elving Collegiate Professorship in Chemistry), Membrane Electrodes, Gas Sensors, Analytical Applications of Immobilized Bio-reagents, Enzyme-linked Competitive Binding Assays, New Stationary Phases for Liquid Chromatography
John Montgomery, Organic Chemistry
Michael D. Morris (Richard D. Sacks Collegiate Professor of Chemistry), Analytical Laser Spectroscopy and Imaging; Electrophoretic Separations
Vincent L. Pecoraro (John T. Groves Collegiate Professor of Chemistry), Synthetic Inorganic and Bioinorganic Chemistry
James Penner-Hahn (George A. Lindsay Collegiate Professor of Chemistry and Biophysics), Biophysical Chemistry and Inorganic Spectroscopy. Investigation of Metal Site Structure in Bioinorganic Systems; X-ray, EPR and NMR Spectroscopy of Proteins
Ayyalusamy Ramamoorthy (Robert W. Perry Collegiate Professor of Chemistry), Solid-State NMR Spectroscopy, Structural Biology of Membrane Proteins, Study of Polymers
Melanie Sanford (Arthur F. Thurnau Professor; Moses Gomberg Collegiate Professor of Chemistry), Organometallic Chemistry
Roseanne Sension, Ultrafast Laser Spectroscopy and Chemical Reaction Dynamics
David Sherman, Medicinal Chemistry
Corey Stephenson, development of new strategies and methodologies for the synthesis of natural products
Nils G. Walter, Chemical biology; Folding and function of catalytic RNA; Biophysical Chemistry of nucleic acids
John P. Wolfe (Arthur F. Thurnau Professor), Organic Chemistry
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Edward T. Zellers, Microfabricated chemical sensors; interfacial chemistry; polymer-solvent interactions; occupational/environ - mental exposure assessment
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Bart M. Bartlett, Inorganic, Materials
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Julie S. Biteen, Physical and Biophysical Chemistry; Single-molecule Imaging and Nanphotonics
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Arthur J. Ashe, III, Organometallic Chemistry of Main-Group Elements
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Thomas M. Dunn, Optical spectroscopy of large (benzoid and fused ring systems) and small (mainly heterogeneous di- and triatomic) molecules; R2PI jet spectra of condensed ring aromatic molecules and the study of conformers and their possible interconversion
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Is provenance no longer interesting, or even a valid pursuit of inquiry?
The basic question this comes down to is: who do you think knows more about what are in the bottles of Van Winkle product? If you think it is Harlen Wheatley and that JVW is lying, then don't buy the product. If you think it is Julian Van Winkle, then you know what is in those bottles and you can make your purchases accordingly.
Pappy Van Winkle sales aren't going to drop no matter what is in those bottles, so I see no reason for Julian Van Winkle to lie about it.
I think they're both right. Julian is saying what he is releasing, while Harlen is saying what he is bottling.
I beleive the Van Winkles know what they instructed BT to do with their whiskey and Harlen either misunderstood or changed the instruction.
I cannot say for sure what level of responsibility Julian or Preston have over exactly what is bottled. So knowing how the new business model works would shed quite a bit more light.
|-o-| [-o-] |-o-| "I'm on the leader"
The point I've been trying to make is that many people here are basing some pretty strong conclusions on hearsay evidence.
That hearsay evidence is not favored is not a negative reflection on the hearers. Hearsay evidence is unreliable for a host of reasons unrelated to the integrity or skills of the hearers.
But for your consideration, the following. Harlen, due to the nature of his position, thinks more about distilling than anything else. The 'Van Winkle whiskey' being distilled today is the same rye as Sazerac rye, and the same bourbon as Weller bourbon. If you think about what Harlen allegedly said in that context, you can see how what he allegedly said and what Julian said are compatible. These are perspectives anyone can think of, if they're not blinded by their passion to catch someone (anyone) in a falsehood.
It's like the metaphor of the four blind guys that were asked to describe an elephant. Each person touched a different part, and they couldn't agree.
Very good analogy.
I added my 2 cents at the end of the comments on the WA blog. It was really comical to see the VW nerds fight and tussle. Like several have said- it's just whiskey! I would really hate to see these same VW nerds try and start collecting bourbons that are from long-ago shut down distilleries! I made mention that I collect Michter's stuff from Pennsylvania. It's a heck of a lot harder (And often quite a bit more expensive!) to find Pennsylvania distillates than pretty much all VW stuff. If we stay on this fanatical path for a few more years, I can only imagine what will happen to VW products- and their prices!
Michter's Distillery, Inc. DSP-PA-17 Schaefferstown, PA.
Until Wednesday Feb. 14th, 1990, Michter's was "The whiskey that warmed the revolution."
Is the winking face simply implied?


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2010 Results - Illinois Prep Top Times
|Published by fastfrankie
Mar 31st 2010, 12:12pm | 340330 views
BLOOMINGTON - Rolling Meadows senior Angelos Karkalis now has a dilemma on his hands.
It seems that before the indoor portion of the track and field season started, Karkalis had set his goals for the year to be in the range of 4:14 or so in the 1,600 for a season-best effort. That included the outdoor season.
After his performance at the 21st annual Illinois Prep Top Times Invitational at the Shirk Center at Illinois Wesleyan in Bloomington on Saturday, things like a state title now begin to come to mind.
"I don't know now," Karkalis said. "I wanted to be in the 4:12-4:14 range this season - guess I need to look at my goals again."
One goal that Karkalis can cross off his list is that of an indoor title. By virtue of his 4:14.95 clocking, Karkalis is the indoor state titlist and now the one to beat when the season turns to the outdoors starting next week.
"I just didn't want to lose," Karkalis said of his race. "I decided that I wanted to make a move and go and not look back."
Karkalis did make his move at the halfway point of the race and really didn't look back until the very end. Had he glanced over his shoulder, he wouldn't have seen a competitor near him. Karkalis was better than three seconds ahead of the rest of the field - which also included Alec Bollman of Palatine, who finished third in 4:18.91 - and his brother Photis who completed the distance double with a 4:27.33 clocking and a 12th-place finish.
"I think he felt like the pace was just not where he wanted to be so he took off," said Meadows coach Frank Schweda. "He wanted to be through the half in 2:06 and when we saw that they were closer to 2:10, he just took off."
The Karkalis brothers weren't the only brother-versus-brother tandem at the meet. Lake Park shot put specialists Jermaine and Jeremy Kline battled for bragging rights.
After the six necessary throws, Jermaine rolled through the field, making him the latest in a long line of great throwers to win at the Top Times meet. Kline's best toss of 60-1.5 bested his brother, who threw a second-place best of 58-6.5.
"I wasn't going to let my brother beat me," Jermaine said. "I just couldn't let that happen."
Also busy for the Lancers was junior Zach Ziemek. Despite performing with a badly sprained right wrist, Ziemek captured medals in three events, including the top medal in the pole vault. His season best of 15-0 in the vault, despite having jumped just 11 times all indoor season, was good enough for a top times title.
Ziemek also captured medals in the long and triple jumps for Lake Park. In the triple jump, Ziemek leaped to a season best of 46-10.25 - better than a foot off his previous best effort. His mark was good enough for second place behind Rickie Walls of Waubonsie Valley, who also marked a personal best with a leap of 48-3.
In the long jump, Ziemek jumped 21-7.25 to finish fifth behind event winner and top-seed Shane Mollidor of Downers Grove South (22-9.25).
"Today was really the first big meet I have been able to compete in," Ziemek said. "Everything just felt real good and I didn't really feel any nerves at all."
Not being nervous also helped out Glenbard East senior Luke Chvatal. As the anchor for the Rams' 3,200-relay team, Chvatal had some work to do to catch Moline and Lane Tech. Gradually Chvatal worked his way to the front, then slowly he reeled in the last Lane Tech runner before catching and passing him on the way to the relay win.
Chvatal teamed with Brad Magnetta, Jimmy Peters and Nathan Peterson to lift the Rams to a 7:57.28 clocking - the second-fastest indoor time in the state this spring.
"Once I saw we were in second place, I planned on sitting on the Lane Tech guy in front of me," said Chvatal, who anchored the relay in a blistering 1:56.7. "Ever since we were sophomores we have been gunning to earn a top three medal at state and that's what our goal is still."
Other individual winners at the meet included Waubonsie Valley senior James Davenport in the high jump. His effort of 6-7 was good enough for the title.
Aaron Beattie of Neuqua Valley ran away from the field early in the 3,200 and won convincingly in 9:12.11.
In the morning session of Class AA, Kaneland's Nick Sinon won the meet title in the high jump by clearing 6-7.


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blue seersucker stripe silk blend halter top
designer's notes
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Just in time for Christmas! Yolanda Foster has created a video to show YOU how to decorate your house. Yolanda tries to go a bit ghetto by mentioning the basket she stores her Christmas cards in… the basket is from Target. PUH-LEEEZE!! You can tell us where you REALLY get your stuff, YoFo! Frontgate, Bergdorf's, Neimans… it don't matter! At least YoFo didn't say she shops at Wal-Mart!
PT Housewife is one to never let a tragedy pass her by! Especially to keep herself relevant and stay in the public's eye.
PT Housewife has jumped on the Hurricane Sandy charity train… 'cause she's so charitable and all that!
(Thanks to SH readers "GF" and "CJ"!!)


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text: Review: Mesmerising Journey weaves a wordless game story Game Reviews 02 March 12 by Patrick Shaw Sony 9/10 Wired rating Wired Stunning visuals and world, delivers an emotional, engaging experience without health bars, voiceovers or dialogue, online play can't be hindered by griefers. Tired Unfortunately brief. Price £9.99 Jenova Chen, the visionary game designer behind Cloud, fl0w and Flower, told me last year at his Los Angeles studio that he foresees a day when videogames won't be labeled as "games."At the time, I didn't exactly grasp what he meant. I'm still not sure what exactly Chen believes games will eventually evolve into. But I have a better idea of what he was talking about now that I've played Journey, the latest game from Chen's studio Thatgamecompany. It constantly challenges your ideas about what videogames can be.This downloadable PlayStation 3 title, available on 13 March, is a multiplayer game. But you can't choose who you play with, and when you meet other players online, there is no way to speak to them over a headset or inflict harm on their character. This forces players to learn to interact with each other and the game's world in new ways.One might worry that by eliminating most videogame conventions, Journey runs the risk of sacrificing its entertainment value. But despite all of the traditional game concepts Journey lacks, the game is never boring. In fact, it's one of the most genuinely mesmerising videogames I've experienced.In Journey players assume the role of a red cloaked figure whose sole ambition is to reach a massive mountain on the horizon. On the way to the mysterious mountain, players traverse sun-scorched wastelands, subterranean caves and arctic lands where visibility is obscured by a relentless blizzard.Journey's worlds are simultaneously barren and beautiful, a duality echoed by the game's minimalistic but moving musical score.Aside from walking around and moving the camera, players can only perform one enigmatic action: Release a strange symbol into the air. This single action has a wide variety of uses. It can help you glide through the air in short bursts, but it can also be used to get the attention of other players.Even without a storyline, I experienced a wide range of emotions throughout my journey -- wonder, fear, even sadness. And this was all done with sparse graphics and minimalistic animation, not with cinematic cut scenes or epic battles.At any point in the game you may run into other players. It's up to you whether you simply pass them by or join up with them to experience the game together. I was amazed by how, even without traditional means of communication, I could work together with other players to solve puzzles I couldn't do on my own.It's a shame that the experience only lasts a few hours. I imagine most gamers will complete Journey in one sitting. After my own travels were at an end, I instantly regretted not spending more time exploring and getting lost in its gorgeous world. There is a pleasant, unexpected surprise at the game's end, though.Even though I often struggled to find meaning within the game's mysterious world, Journey doesn't need to be explained. It's still a fulfilling experience.Source: Wired.com Edited by Dan Smith Comments Latest on wired.co.uk


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And this is why it's called a "Honey Wagon"
Sweet Mary Mother of all that is good and pure. It's not even honey; it's like honey covered strawberries wrapped in sweet smelling herbs and perfection.
Could her shorts be any shorter ??
it looks like she was about to throw up and her body guard or w.e asked her if she was ok and she looks like she is signaling like im okay… idk just sayin … all in all love her


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Victims in Lake Powell boat crash identified
Equipment problems forced dive teams to call off a search Friday for two Utah women missing in Lake Powell after a motorboat crash.
At least one other woman had been confirmed to have died in the Thursday crash.
The driver of the motorboat may have been distracted by children onboard when the boat was moving toward a houseboat about 8:15 a.m. Thursday near the Dangling Rope Marina, Kane County Sheriff's Sgt. Alan Alldredge wrote in a press release.
South Jordan resident Adrian Jackman, who was driving the motorboat, veered at the last minute but still struck the front corner of the houseboat, Alldredge wrote. The motorboat overturned with 13 people on board, including seven adults and six children, who were on a family trip from the Salt Lake City area.
Adrian's 57-year-old wife, Marilyn Jackman, died; Marilyn's 22-year-old daughter Jessica Jackman, and Valerie Rae Bradshaw, 29, of Sandy, were missing in the water.
Other individuals on the motorboat suffered minor injuries.
Adrian Jackman and his 11-year-old granddaughter were flown to a hospital in Flagstaff, Ariz., where they were expected to survive. Another person was transported by boat and then by ambulance to the Page, Ariz. hospital.
All of the children were wearing life jackets. No one on the houseboat was injured.
The National Park Service, Utah State Parks and Kane County Sheriff's Office were working to find the missing victims and to investigate the accident.
A National Park Service dive team on Friday used a robot with a camera to search the area, but technical problems ended the effort shortly after 2 p.m.
Meanwhile, a Utah Department of Public Safety dive team was due to arrive as early as Friday night, bringing with them a "side scan sonar" to search for the missing victims.
The water is about 400 feet deep at the crash site, Alldredge wrote.


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P. Michael Conn
In work conducted over the last 12 years, Conn and his team have identified an underlying biological principle that has dramatically changed scientists' understanding of cellular mutations that result in human disease. He has demonstrated that it is possible to manipulate and redirect the routing of non-functional diabetes, Alzheimer's disease and cataracts. This approach is described at http://en.wikipedia.org/wiki/pharmacoperone
It is becoming well-recognized that mutations of receptors, enzymes and ion channels frequently result in protein misfolding and subsequent retention by the cell's quality control system. Misfolding can result in protein molecules that retain intrinsic function yet become misrouted within the cell and, for reasons of mis-location only, cease to function normally and result in disease. This contrasts with the prior presumption that mutational inactivation always reflects loss of intrinsic function (i.e., a receptor that either fails to recognize ligand or does not couple productively to its effector). Recognition of this alternate concept immediately presents the therapeutic opportunity to correct misrouting and rescue mutants, thereby restoring function and, potentially, curing disease.
Pharmacoperones are small molecules that enter cells, bind specifically to misfolded mutant proteins, correct their folding, and allow them to escape retention by the cellular quality control system. They then route to the plasma membrane (or other site) where they can function normally. The biochemical mehanism of action has been identified and an in vivo proof-of-principle has been accomplished.
In principle, the pharmacoperone rescue approach might apply to a range of human diseases that result from misfolding - among these: cystic fibrosis, hypogonadotropic hypogonadism, nephrogenic diabetes insipidus, retinitis pigmentosa, hypercholesterolemia, cataracts, and neurodegenerative diseases (Huntington's, Alzheimer's, Parkinson's). In the case of particular proteins, this approach has succeeded with a striking number of different mutants, supporting our view that pharmacoperones will become powerful ammunition in our therapeutic arsenal.
P. Michael Conn is the Director of the Office of Research Advocacy, Senior Scientist in Reproductive Sciences & Neuroscience (ONPRC), and Professor of physiology and pharmacology, cell biology and development, and OB/GYN at OHSU, where he served for eleven years as special assistant to the president and as Associate Director of ONPRC. After receiving a B.S. degree and teaching certificate from the University of Michigan (1971), an M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the National Institute of Child Health and Human Development at NIH, then joined the Department of Pharmacology at Duke University Medical Center, where he was promoted to Associate Professor in 1982.In 1984, he became professor and head of pharmacology at the University of Iowa College of Medicine, a position he held for eleven years.
Conn is the prior Editor-in-Chief of Endocrinology, Molecular and Cellular Neurosciences (founding editor), Methods in Neuroscience, Endocrine, Contemporary Endocrinology, and Reviews in Endocrine and Metabolic Disease, Recent Progress in Hormone Research and prior editor of J Clinical Endocrinology and Metabolism. He is presently the editor of Progress in Molecular Biology and Translational Research. He is the editor of texts in pharmacology (Essentials of Pharmacology), neuroscience (Neuroscience in Medicine), neuroendocrinology (Neuroendocrinology in Physiology and Medicine), endocrinology (Endocrinology: Basic and Clinical Principles) and molecular endocrinology (Principles of Molecular Regulation), as well as more than 100 volumes in endocrinology and neuroscience.
Conn served on the National Board of Medical Examiners, including two years as chairman of the reproduction and endocrinology committee. Conn is best known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone in the pituitary and CNS. He has authored or co-authored nearly 300 publications and 130 books in this area.
The work of his laboratory has been recognized with a MERIT award from the NIH, the J.J. Abel Award of the American Society for Pharmacology and Experimental Therapeutics, Weitzman, Oppenheimer and Ingbar Awards of the Endocrine Society, the National Science Medal of Mexico (the Miguel Aleman Prize), and the Stevenson Award of Canada. In 2004, he received the Oregon State Award for Medical Discovery (Medical Research Foundation of Oregon). His projects have been continuously funded by peer-reviewed federal support since 1976. He is a distinguished alum of Baylor College of Medicine (2012).
Conn is a previous member of the Council for the American Society for Cell Biology and the Endocrine Society and is a prior President of the Endocrine Society, during which time he founded the Hormone Foundation and worked with political leadership to create much of our nation's program in diabetes. He served on the FASEB Board of Directors. Conn's students and fellows have gone on to become leaders in industry and academia. He is an elected member of the Mexican Institute of Medicine and a fellow of the American Association for the Advancement of Science (AAAS).
Smithson DC, Janovick JA and Conn PM. (2013) Therapeutic rescue of misfolded/mistrafficked mutants: automation-friendly high throughput assays for identification of pharmacoperone drugs of GPCRs. Methods Enzymol. 521:3-6.
Stewart MD, Deng J, Stewart CA, Mullen R, Wang Y, Lopez S, Serna MK, Huang C-C, Janovick JA, Pask A, Schwartz RJ, Conn PM and Behringer RR. (2012) Mice harboring Gnrhr E90K, a mutation that causes protein misfolding and hypogonadotropic hypogonadism in humans, exhibit testis size reducation and ovulation failure. Mol Endocrinol. 26(11):1847-1856.
Conn PM, Smith E, Hodder P, Janovick JA and Smithson DC. (2013) High throughput screen for pharmacoperons of the vasopressin type 2 receptor. J Biomol Screen. In Press.
Ulloa-Aguirre A, Zarinan T, Dias JA and Conn PM. (2013) Mutations in G protein-coupled receptors that impact receptor trafficking and reproductive function. Mol Cell Endocrinol. In Press.
Dancet EAF, Kariuki T, Farah IO, Mwenda JM, Chai D, Kyama CM, Nyachieo A, Falconer H, Brannstrom M, Stouffer R, Zelinski M, Conn PM, Parker JV, Fazleabas A, Slayden OV, Mitalipov S, Golos T, Chan A, Strauss J, Hearn J, Else J, Goddeeris B, Hau J, Brasky K and D'Hooghe T. (2013) The role of scientists and clinicians in raising public support for animal research in reproductive biology and medicine. Biol Reprod. 88(2):33.
Conn PM, Parker JV. (2008) The animal research wars. Skeptic Magazine 13(4):19-20.
Conn PM, Parker JV. (2008) Winners and losers in the animal research war. American Scientist 96(3):184-186.
Conn PM, Parker JV. (2008) The animal research war. FASEBJ. 22(5):1294-1295. PMID: 18450645.
Conn PM. (2008) The war on animal research. The Scientist 22(3):40-46.
Conn PM, Parker JV. (2008) Warning: animal extremists are dangerous to your health. The Skeptical Inquirer. 32(3):26-31. (Reprinted in: Frazier K, ed, Science Under Siege, Prometheus Books, 2009.)
Conn PM, Parker JV. (2008) Physiologists embedded in the animal research war. Physiologist 51(3):85, 94-95. (Reprinted with permission in the Brazilian Society of Physiology Newsletter, June 2008.) PMID:18595298
Conn PM. (2009) Terrorism in the name of animal rights. The LA Times (syndicated by The LA Times-Washington Post). November 12, 2008. (Reprinted in, Hamilton J, ed. Issues that Concern You: Activism, (ICYAC) 2009. Gale Cengage Learning)
Conn PM, Parker JV. (2008) Awakening the american public. RDS News (UK). Winter 2008, pp4-5.
Conn PM, Parker JV. (2008) Terrorizing medical research. The Washington Post (syndicated by the LA Times-Washington Post) December 8, 2008 pg a19.
Conn PM, Parker JV. (2009) Neurologists in the cross-hairs, World Neurology 24(2):8.
Conn PM and Parker JV. (2011) America's other most wanted.Wall Street Journal, May 18, 2011 vol. CCLVII no. 115 page a15.
Parker JV and Conn PM. (2011). From test tube to hypodermic needle: a prescription for educating the public on the value of animal research. The Scientist. 25(11/12):28-29.
Conn PM, Parker JS. (2008) The Animal Research War. Macmillan/Palgrave ISBN-10: 023060014X ISBN-13: 978-0230600140.
Conn PM. (2008) Sourcebook of Models for Biomedical Research. Humana Press. ISBN13: 978-1-58829-933-8; ISBN10: 978-1-58829-933-3.
Conn PM. (2008) Neuroscience in Medicine. Springer, Totowa, NJ third edition.
Jennes L, Traurig H, Brueckner JK, Conn PM. (2008) Atlas of the Human Brain (on CD). Springer.
Conn PM (editor-in-chief) (2011) 30 Recent volumes in Progress in Molecular Biology and Translational Science, Elsevier, San Diego, CA.
Conn PM. (2011) Methods in Enzymology, vol. 489-491, The Unfolded Protein Response and Cellular Stress, Part A-C. Academic Press, New York. ISBN: 978-0-12-385116-1
Conn PM (editor) (2011) Reliable Lab Solutions, Essential Ion Channel Methods. Science Press (Elsevier), China. ISBN: 978-7-03-030602-9.
Conn PM (2012) Methods in Enzymology, vol. 504-506, Imaging and Spectroscopy of Living Cells, Part A-C. Academic Press, New York. (In press).
See a full listing of Dr. Conn's publications


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I was incorrect in describing the smelter fee example.
What I should have said: Assume that a company that produces 20,000 tonne nickel annually in its concentrates.
First Case
With nickel in concentrate grading 10%, the concentrate would weight 200,000 tonne
Second Case
With nickel in concentrate grading 20%, the concentrate would weight 100,000 tonne
Transport tonnage to the smelter for the 20% concentrate would be half of the 10% concentrate, resulting in transportation savings.
The same would apply to the amount of concentrate going through the smelter, which would be half the amount for the 20% concentrate. In the end, the same amount of nickel 20,000 tonne or 44.09 milillion pounds of nickel minus smelter losses would be produced.


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General Frequently Asked Questions
How do I change my name on my account?
To update your name on your account, please send a copy of your Social Security card, a certified copy of your marriage license, divorce decree or other duly executed court order verifying your name change to the South Carolina Public Employee Benefit Authority (PEBA) Retirement Benefits at the following address:
South Carolina Public Employee Benefit Authority
Retirement Benefits
Attention: Enrollment Department
Post Office Box 11960
Columbia, South Carolina 29211-1960
How can I update my address?
You may change your address by calling our Customer Services department, updating it with your employer or by logging into Member Access and selecting the Change Address link. You may also send a written notification to our office which includes your signature, printed name, Social Security number and new address. Notice of an address change may be mailed to: South Carolina Public Employee Benefit Authority, Retirement Benefits, Attention: Enrollment Department, Post Office Box 11960, Columbia, South Carolina 29211-1960.
Can I obtain my account balance online?
Yes. If you have not received a refund of your contributions, you may view or print a member statement by logging into Member Access and selecting the Statement link.
May I borrow money from my South Carolina Public Employee Benefit Authority (PEBA) Retirement Benefits account?
No. There are no provisions that allow a member to borrow funds from retirement accounts held at the South Carolina Public Employee Benefit Authority.
How do I withdraw money from my PEBA Retirement Benefits account?
If you leave your job and terminate all employment with any employer covered by PEBA Retirement Benefits and do not retire before you are eligible to retire, you may elect to receive a refund of your accumulated member contributions and interest by completing a Refund Request (Form 4101) and returning it to PEBA. You may submit your refund request immediately upon termination; however, by law, payment may not be issued less than 90 days after you cease to be an employee. If you receive a refund, you forfeit your rights to any future service retirement or disability benefit. Employer contributions are not refunded. If you are working for two or more covered employers and/or contributing to more than one retirement account (i.e., working two jobs and paying into a South Carolina Retirement System (SCRS) and a Police Officer Retirement System (PORS) account), you must stop working in all correlated systems to be eligible to receive a refund from any account. PEBA Retirement Benefits is required to withhold federal taxes of 20 percent on the taxable portion of any refund that is eligible for a rollover but is not transferred directly into another qualified retirement plan. Other taxes or penalties may apply as well. Be sure to check with an accountant or tax advisor regarding your tax liability.
How do I change my beneficiary?
If you have not retired, you may change your beneficiary designations by submitting an Active Member Beneficiary Form (Form 1102). You may complete and print this form from our website or contact our Customer Services department at 803-737-6800 or 800-868-9002 (within S.C. only) to request a form be mailed to you. All beneficiary changes require that your signature be notarized. Completed forms may be mailed to PEBA Retirement Benefits, Attention: Enrollment Department, Post Office Box 11960, Columbia, South Carolina 29211-1960.
How is my average final compensation (AFC) calculated and how is unused annual leave pay factored into my monthly benefit?
Your monthly retirement benefit is calculated using your average final compensation (AFC), years of service credit and a benefit multiplier which varies among systems. Under current law, if you are a Class Two member your AFC is calculated by adding the total of your 12 highest consecutive quarters of earnable compensation (utilizing quarterly information reported to PEBA Retirement Benefits by your employer) and dividing by three. For Class Three members your AFC is calculated using your 20 highest consecutive quarters of earnable compensation. Also under current law, an amount up to and including pay for 45 days of unused annual leave from your last termination payment may be included before averaging your 12 highest consecutive quarters of earnable compensation for Class Two members only. For work performed after December 31, 2012, your AFC does not include any overtime pay not mandated by the employer. Your employer provides this information to PEBA Retirement Benefits when you retire.
Can I schedule an appointment with a PEBA Retirement Benefits' counselor and if so, what do I need bring to bring to the appointment?
Yes, you may schedule an appointment for an individual consultation with one of our retirement counselors. Please bring your driver's license, and a copy of your birth certificate, as well as the birth certificate of your beneficiary(s) if you are planning to choose a survivor payment option. Options B and C are survivor options that provide for a continuing monthly annuity to be paid to your surviving beneficiaries upon your death. When completing the retirement application, the counselor will ask for the Social Security numbers of your beneficiary(s). You may also bring your latest check stub so we may use that information in calculating benefit estimates for you and a voided check for completion of a direct deposit form.
If I choose to name multiple beneficiaries, how are the payments dispersed?
If you select Opion A (maximum) benefit payment option and multiple beneficiaries, then each surviving beneficiary will receive an equal share of any contributions and interest in your account that was not paid to you in the form of a retirement benefit. If any beneficiary predeceases you, the remaining beneficiaries will receive equal shares of any unpaid contributions and interest. If you select Options B or C which provide survivor benefits and multiple beneficiaries, then each beneficiary will receive an equal share of the monthly benefit. If any beneficiary predeceases you, the deceased beneficiary's share ends and the remaining beneficiaries will continue to receive only their original share of the benefit.
I'm currently a State Optional Retirement Program (State ORP) participant. Can I switch and become an SCRS member?
Each year, there is an annual enrollment period from January 1 to March 1. During this time, you, as a State ORP participant, may irrevocably switch to SCRS if you have at least one but no more than five years of State ORP service at the time of the open enrollment period.
If, as a State ORP participant, you do not make the change within the allotted time, you will, by default, continue your State ORP participation and forfeit your one-time opportunity to elect SCRS membership. If you join SCRS during the allotted time, you may purchase all or a portion of your State ORP service at any time after joining SCRS. The cost, which is determined by PEBA's independent actuary, will not be less than 16 percent of your career highest fiscal year compensation for each year purchased.
Who can purchase additional service credit?
Only active members are eligible to purchase additional service credit. Active members are those members currently working for an employer participating in a retirement system administered by PEBA, who are earning service credit, making regular contributions, and who have not retired or terminated from covered employment.
How much does it cost to purchase additional service credit?
Effective January 2, 2013, legislation was implemented which changed the process for calculating the cost of certain types of service credit to be at least equal to the true actuarial cost. The actuarial neutral cost involves a complex calculation that takes into account the member's age, service credit, salary, average final compensation (AFC), and portion of service to be purchased. In addition, there is a minimum statutory cost which must be at least 16 percent (qualified service) or 35 percent (nonqualified service) of the member's current or career highest fiscal year salary for each year purchased.
How long does it take to get an invoice?
In order to process your service request we may need verification from you, your current or former employer(s) or other agencies. Because each type of service credit requires a variety of verification we cannot provide a definite response time. However, our goal is to provide you with a payment invoice(s) within 30 days after receiving all documentation and verification needed to process your request.
How much service credit can I purchase?
There is no limit on the numbers of years you may purchase for most service types. However, you may only purchase six years of military service and five years of nonqualified service.
May I purchase a portion of service credit?
Yes. You may purchase all or any portion of each type of service credit. However, you may purchase the same type of service only once within a fiscal year.
Can I obtain a cost estimate for any service type?
The Service Purchase Cost Estimate Calculator provides an unofficial cost estimate to purchase certain types of service based on an actuarially neutral cost. If you are a member of a retirement system administered by the S.C. Public Employee Benefit Authority, you can access the calculator through Member Access by clicking the Member Login button at the top of this page. The calculator does not provide cost estimates for withdrawn service, workers' compensation, transfer SCRS to PORS, and Convert Class I to Class II. To receive a cost estimate to purchase those types of service, please contact Customer Services at 803-737-6800; 800-868-9002 (within S.C. only).
Will I be notified when my payment is received?
Yes. You will be notified by our Service Accounting Department upon receipt of your lump sum payment, rollover, or your election to participate in the Installment Service Purchase Program.
To access more FAQs, please visit our Retiree Frequently Asked Questions page. Our Customer Services Call Center is dedicated to assisting you with matters related to your retirement benefits. You may contact Customer Services at 803-737-6800, toll free at 800-868-9002 (within S.C. only), or through our online contact form.


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THE Guam Community College yesterday confirmed only $324,000 has been received so far out of the $1.435 million current fiscal year funding allocated from the Manpower Development Fund (MDF) for GCC's apprenticeship program.
GCC President Mary Okada made the confirmation during the public hearing for Bill 84 yesterday. As pointed out in the bill, GCC had not been receiving its full appropriation from the MDF for the past several years.
"Under the current law, the college receives 70 percent of the collected revenues. Although this funding mechanism has been in place for quite some time, collections have not been coming in as anticipated," Okada testified.
Sens. Ben Pangelinan and Tina Muña-Barnes introduced Bill 84, a measure seeking to allocate around $2 million from unappropriated revenues collected from the Tourist Attraction Fund (TAF) to support GCC's fiscal year 2013 apprenticeship program.
The appropriation will also be available for GCC to fund the operations of other programs as approved by the board of trustees and administration of the college after meeting all apprenticeship program obligations and requirements.
For FY2013, TAF funds are expected to earn revenues of around $25 million. Approximately $23 million of this is already appropriated.
The Office of Public Accountability reported recently that GCC has not yet received any of its Manpower Development Fund appropriations.
Moreover, OPA reported there were unexpected allotment shortages made to the MDF that directly correlates to the number of H-2 workers on Guam. Due to the decline in the construction industry and the delay of the military buildup, the actual collections from MDF were just 41 percent or $695,000 less than the amount appropriated.
In total, GCC saw an overall appropriation decrease of 2 percent from the general fund and 60 percent from MDF, the OPA said. This shortfall has resulted in cuts to funding contractual services, supplies, and other operational costs to the college.
In her testimony, Okada said: "In order to continue our mission to provide our people with training and education, they need to be successful, productive members of society and GCC needs your support. The passage of this bill helps us all achieve this goal."
For the past several years, Okada said the community college has been increasing its number of apprentices, adding the program currently has 443 apprentices in comparison to 2006, where they only had 98 apprentices.
The college, she added, has worked aggressively to get the local workforce trained in many different areas – from diesel mechanics, to air-conditioning maintenance and repairs, and to police officer training, among others.
Meanwhile, Pangelinan said Bill 84 would provide additional resources to the GCC apprenticeship program to meet some shortfalls in funding based upon estimates that were developed by the administration and adopted by the Legislature with regard to the MDF.
"When we looked at the adopted revenues versus the actual collection of the revenues, we knew there was a significant shortfall."
He said they looked at revenue sources that will be able to support the work of the community college. Through research and analysis, they found out there are unappropriated funds available via the TAF.
"We thought that the TAF would be an appropriate revenue stream to assist the college in its mission and efforts since a lot of the training it does and the program it implements help support the tourism industry," Pangelinan said.
GCC not getting full MDF funding for apprenticeship program
THE Guam Community College yesterday confirmed only $324,000 has been received so far out of the $1.435 million current fiscal year funding allocated from the Manpower Development Fund (MDF) for GCC's apprenticeship program.


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Originally posted by Thomas Paul: Peter, what about when you are working with RMI or EJB? Don't you (as the client-side developer) get an interface which reveals the programming interface wihout revealing anything about the implementing class?
Originally posted by Peter den Haan: I did perhaps misread the authors' statement though.


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A few years ago when I was picking my 5 year old daughter up at preschool at around 11:30 or so, she told me she smelt pizza. I in return told her they are probably having pizza in the lunchroom. She then replied it smells like "Sammy's" I told her "well they aren't serving Sammy's in the lunchroom, and when we turned the corner of the hallway there was a man carrying boxes of Sammy's pizza. I laughed and laughed. She still can smell Sammy's pizza a mile away!!
Smelling Sammy's from a mile away
By: mdaloiaSubscribe Channel: Local Interest Location: Duluth, MN
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New York, NY, US
4th year B'Arch Architecture student studying in Cornell University. My interests lie in architectural design and printmaking.
Robert A.M. Stern Architects, New York, NY, US, Architectural Intern
E123 Consultants, Singapore, SG, Engineering Intern
WOW Architects, Singapore, SG, Architectural Intern
Cornell University, Ithaca, NY, US, BArch, Architecture
Syracuse University, Syracuse, NY, US, BArch, Architecture
Interclass Mid-Review Competition for Crisis Center in Kerala, India, 1st Place
Singapore Archifest Zero-Waste Pavilion, 1st Place
During my internship, I was part of the team to design and win the Zero-Waste Pavilion in Singapore during Archifest 2012.
Interclass Competition for Town Hall, Award
One of the four projects selected by a jury to be further developed throughout semester by my peers.
Deans List, Award
Deans List, Award
College Colors Award, Award
Awarded the College Colors Award in 2008, 2009 for Outstanding Leadership in Basketball
12x: An Art Experiment, Other
Artwork exhibited and auctioned at 12x: An Art Experiment, a small scale arthouse event, in collaboration with young artists in Singapore.
Top in Arts Elective Program, Award


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- Filed Under
Newspapers are threatening to become a thing of the past due to the exploding use of the internet to "get the latest news." The true beauty of a newspaper is the fact a person taking the time to read everything in the paper becomes aware of the little things going on in the local community, the nation and the world. The little news items seem to have a way of blossoming into something more over time when taking into consideration everything else going on in the world.
Take the development of Nevada Copper's properties in Yerington, for instance. This is a big deal for many. It is something potentially worth billions, affecting Yerington, the County school system, the County, the State, and the nation. People need to know what is going on there and how it will affect them, but you won't find much about it on the internet if you don't know where to look. Why is the knowledge of this development important? If more people knew what's going on with the Nevada Copper development, and the other lesser-known proposed projects, you can bet the pressure on our elected officials to improve roads and other infrastructure to the area would increase ten fold. If that were done, business would be able to plan for the "boom" to come.
The only way for people, in general, to have any idea of such an important project is to sit down and read about it in the paper. The same goes for ancillary businesses. People need to slow down and read a paper, but as I said before, people are becoming oriented to news that only affects them, and the internet is only making the situation worse.
* * * * *
I like Robin Roberts. She is an interesting person who had the misfortune to develop breast cancer and, just when she was recovering, came down with a rare condition that was destroying her bone marrow. Robin was very fortunate, her sister was a perfect donor, and her willingness to donate bone marrow saved Robin's life. I have to visit a cancer center to have my blood drawn two or three times a year to reduce my amount of accumulated iron due to the fact I have hemochromatosis. This is a condition in which a person can't metabolize iron. It's very damaging to joints, internal organs, and, in some cases, can be fatal. I'm lucky a doctor diagnosed the condition before it became irreversible.
I said all that in order to give a reason I have to go to a cancer center, as my condition is treated by an Oncologist. Due to all the visits, I have had the chance to meet folks with cancer of all types, and a large number of them don't have the resources Ms. Roberts had access to. All of them go through the same type of trial Ms. Roberts is going through, and all of them are deserving of the same consideration and recognition she is getting. All of them are putting up the same battle as Ms. Roberts.
This is a tough go, and my hat is off to every person who survives.
-Charles Lawson is a native Nevadan, retired contractor/project manager and longtime Lyon County resident. E-mail him at firstname.lastname@example.com


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WHATS HAPPENING: EVENTS CALENDARComment on this story
In the spirit of sharing, KFC South Africa knows that spending time together is one of the most important things we can do. With that in mind, KFC has found a unique way to bring fun and special moments to its fans this summer.
Come and join KFC in going large with its exclusive, no-charge movie and outdoor experience, now in Johannesburg by popular demand, after its huge success in both Durban and Cape Town. These are going to be full movie-themed experiences with the kind of entertainment you don't want to miss, so join in an evening of free outdoor fun. Well-known films Grease and Back to the Future will be on show on the 22 and the 23 of February 2013 respectively with Top Gun on the 1 March and Avengers on 2 March 2013.
A giant inflatable KFC photo booth bucket measuring 5.5 meters high and 6.5 meters wide will make this an evening to remember, with exciting wardrobe accessories and options will give you the opportunity to capture this once-in-a-lifetime experience with your friends. Tag yourselves on Facebook as well as get the chance to enter the exciting "Bucket List" competition to win a unique experience.
On arrival, you can expect free popcorn, theme prop packs, giant board games and entertainers mimicking classic scenes from the movie on show. You will receive a "movie experience" gift pack upon your arrival which will give you the chance to join in the action.
Further details and restrictions can be found at: www.kfc.co.za www.facebook.com/kfcsa and www.twitter.com/kfcsa
Venues and dates below:
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