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Fidelity Investments is committed to delivering the best customer experience in the financial services industry. We help millions of people save and invest through personal investment accounts and workplace savings plans. Our associates build long-term relationships with our customers, helping them navigate our full range of investor products and services, including one-on-one investment guidance, . . .
The VP, Executive Planning Consultant in Hartford, CT will have the responsibility for maintaining and nurturing relationships with senior executives and management leaders of key Workplace benefit plan clients. In this capacity, the EPC will be the focal point for financial planning and guidance for a select group of executives and be an integral part of a cross company team consisting of a manag . . .


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Colon calls: Listeners help Johnny prep for his colonoscopy
Johnny reviews his doctor's prep instructions for his upcoming colonoscopy; callers share advice and stories from their own procedures.
Hey Johnny,
You bring laughter to my day every day.
I just had a colonoscopy on Monday and it is a horrible experience. The procedure is not that bad but the prep is horrendous. You cant eat the entire day before and you drink the most god awful drink you can imagine. I spent Superbowl Sunday on the couch drinking the horrible stuff and running back and forth to the bathroom. Then the morning of the procedure I had to drink more stuff. After the procedure the doctor told me I wasn't cleaned out enough and she couldn't see much because she could only see brown and green stuff, including seeds and nuts. I thought for sure they would have been able to use a vacuum to clean me out. lol So next year I have to do the prep for three days in a row which will probably kill me. Also, the anesthesia knocks you out so the day after the procedure you feel literally like crap!!!!!!!!! Prepare to spend three days total in agony.
Good Luck!
Comments are closed.

subset: commoncrawl


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Terrell Owens debuts in big way for Allen Wranglers
Photo: Brad Loper/Staff Photographer
Former NFL receiver Terrell Owens is introduced prior to the start of the Allen Wranglers in Indoor Football League game against the Wichita Wild at the Allen Events Center in Allen, Texas Saturday, February 25, 2012.
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US has 15,000 troops in Kuwait: Senate
A US Senate report indicates that the United States has now nearly 15,000 troops in three bases across Kuwait- - triple the average number of American forces in the Middle Eastern country before the US-led invasion of Iraq in 2003. The Senate Foreign Relations Committee released the report on Tuesday, considering how to promote the US interests in the Persian Gulf region after the American forces left Iraq last year. According to the report, having the military bases throughout the region is a "lily pad" model to allow for a rapid escalation of military forces. The Kuwaiti bases "offer the United States major staging hubs, training ranges, and logistical support for regional operations," the report said, adding, the "US forces also operate Patriot missile batteries in Kuwait, which are vital to theater missile defense." US Secretary of Defense Leon Panetta has recently said there are roughly 40,000 American troops in the area to respond to the region's possible conflicts. The American forces have also been stationed in Qatar, the United Arab Emirates and Bahrain. Pentagon spokesman Capt. John Kirby had said, "The secretary (of defense) has been very clear that while we do this shift in focus to the Asia-Pacific, that the Central Command area of responsibility will still remain a high priority." MSH/GHN


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Skullcandy G.I. Headphones Kick Ass, Take Names
Rock out in style with Skullcandy's slick DJ style G.I. headphones. They come in a variety of styles from Desert Camo to Rasta, including a couple of military-inspired designs with bullets on the leather band. The speakers on these bad boys are also made of soft leather and swivel a full 90 degrees. $69.95 may sound… »


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My kids and I thought this would be a great tribute to Brandon Roy and his great game he had last night.
making a snowman
By: irishfireSubscribe Channel: Sports & Recreation Location: Salem, Oregon on little john lp.
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Jason Derülo "Talk Dirty" (iTunes+)
After the success achieved with his smash 2 Chainz-assisted single 'Talk Dirty', and after premiering the videos of the next official singles 'Trumpets' and 'Stupid Love', American singer-songwriter and dancer Jason Derülo is ready to add them to his anticipated album for the American market.
During an interview with Power 106 on iKts 'Valentine's Crush' concert in Los Angeles, Derulo confirmed that the full-length U.S. version of his third international studio album 'Tattoos' is called 'Talk Dirty' and serves as the follow-up to his last year's EP 'Tattoos'. The new album was released on digital retailers in the USA on April 15, 2014 via Beluga Heights and Warner Bros.
Alongside the pre-order of the album on iTunes, Derulo released the track 'Vertigo' featuring his girlfriend, American singer Jordin Sparks as iTunes countdown single on March 17, 2014. The track was also included on the international version of the album 'Tattoos'.
- 'Talk Dirty' (feat. 2 Chainz)
- 'Wiggle' (feat. Snoop Dogg)
- 'Trumpets'
- 'Bubblegum' (feat. Tyga)
- 'Vertigo' (feat. Jordin Sparks)
- 'Kama Sutra' (feat. Kid Ink)
- 'Zipper'
- 'The Other Side'
- 'With the Light On'
- 'Stupid Love'
- 'Marry Me'
'Talk Dirty' is available on iTunes (BUY / DL)


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PHILADELPHIA (AP) — A judge dismissed a lawsuit by a former suburban Philadelphia teacher fired two years ago for writing on her blog about students who were "disengaged, lazy whiners."
Natalie Munroe had accused the Central Bucks School District and administrators of violating her free-speech rights.
U.S. District Judge Cynthia Rufe on Friday granted the defendants' motion to dismiss the suit, The (Doylestown) Intelligencer (http://bit.ly/1uHCYQb ) reported Thursday. The judge ruled that the defendants were within their rights to conclude that the teacher's posts "would erode the necessary trust and respect between Munroe and her students."
"Far from implicating larger discussions of education reform, pedagogical methods, or specific school policies," the judge said, the postings "mostly complained about the failure of (Munroe's) students to live up to her expectations."
Munroe's attorney, Steve Rovner, said they planned an appeal.
"We believe that it was protected free speech, and that her right to free speech is greater than the rights the school district has asserted," he said.
Munroe's blog did not identify her school, district, colleagues or students, though it did include her picture and identified her as "Natalie M."
"My students are out of control," Munroe wrote in one post. "They are rude, disengaged, lazy whiners. They curse, discuss drugs, talk back, argue for grades, complain about everything, fancy themselves entitled to whatever they desire, and are just generally annoying."
The judge noted that Munroe also described a student as "a complete and utter jerk in all ways" and another as a "cheater and liar."
Information from: Bucks County Courier Times, http://www.buckscountycouriertimes.com
Copyright 2014 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
A look at the winter weather news in the D.C. area.
Browse through photos of the event and festivities in New York City.


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- Faith and Fear in Flushing - http://www.faithandfearinflushing.com -
Standard September Mets Loss Blog Post
Posted By Greg Prince On September 11, 2010 @ 5:30 am In 1 | Comments Disabled
Expression of resigned exasperation with latest result.
Acknowledgement that result doesn't matter at this stage of season, yet it is always frustrating to encounter this sort of result.
Link to article spelling out game details [1].
Snarky aside.
Key example of what went wrong in game.
Assertion of saving grace, focusing on how this was just one game and player who committed key example of what went wrong in game will hopefully improve.
Snide allusion to disliked secondary player's particularly poor performance.
Expression of resigned exasperation that big picture is as bleak as latest result.
Link to article about newest discouraging development [2].
Passing attempt to project what newest discouraging development means for foreseeable future.
Explicit admission that future can't be foreseen but newest discouraging development is indeed discouraging.
Weaving together of various recent discouraging developments so as to suggest overarching discouraging trend that makes rooting for team difficult.
Allusion to most embarrassing recent discouraging development that constitutes most disturbing manifestation of trend.
Link to terrible article [3] illustrating dimwitted coverage of recent discouraging development.
Link to good article [4] serving as counterweight to dimwitted coverage.
Half-hearted analysis of most embarrassing recent discouraging development (undermined by personal conviction that most recent discouraging development was very much a non-story, yet not commenting on it at all after a few days doesn't feel right, either).
Link to archived blog post to demonstrate longstanding pattern of discouraging developments [5].
Conclusion of analysis finding all parties are at least partially at fault (should include at least one point nobody else has made).
Assertion of enduring fondness for team in spite of all prevailing evidence that team has become too exasperating to inspire any fondness whatsoever.
Expression of dismay that season will soon be over in spite of latest result, recent discouraging developments and bleak big picture.
Link to archived blog post from when things were better [6]to serve as reminder that things aren't always this bad.
Gratuitous reference to Mike Hessman (optional).
Article printed from Faith and Fear in Flushing: http://www.faithandfearinflushing.com
URL to article: http://www.faithandfearinflushing.com/2010/09/11/standard-september-mets-loss-blog-post/
URLs in this post:
[1] game details: http://espn.go.com/mlb/recap?gameId=300910121
[2] newest discouraging development: http://sports.espn.go.com/new-york/mlb/news/story?id=5555600
[3] terrible article: http://msn.foxsports.com/mlb/story/new-york-mets-in-miserable-position-091010
[4] good article: http://scratchbomb.com/2010/09/this-joke-of-an-organization-isnt-funny-anymore.html
[5] longstanding pattern of discouraging developments: http://www.faithandfearinflushing.com/2009/07/28/yet-another-sterling-example/
[6] when things were better : http://www.faithandfearinflushing.com/2006/09/19/we-win/
Click here to print.
Copyright © 2010 Faith and Fear in Flushing. All rights reserved.


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Adidas Moves Pulse Perfume
By Adidas for Women
Adidas Moves Pulse Perfume by Adidas, Adidas moves pulse was launched in 1999 by coty . Put out by the design house of adidas, it also received a prestigious fifi award in 2000. Pulse for women offers a high-energy fragrance created with cool citrus and refreshing florals, the scents of which will make you move and play, and invite you to live life to the fullest. This sparkling blend compliments busy lifestyles and is ideal for all day use. It opens with top notes of pink lady, apple, ... Read More ... Read More mirabella, plum and orange splash. At the heart are the notes of indigo, violet, fresh tulip, flirty freesia night and blooming jasmine, placed on woody base of sensual creamy woods and white amber. All products are original, authentic name brands. We do not sell knockoffs or imitations.
- H Alpert Company
- Habanita
- Habanita L'esprit
- Halle
- Halle Berry
- Halle Berry Pure Orchid
- Halloween
- Halloween Blue Drop
- Halloween Bubbles
- Halloween Fever
- Halloween Freesia
- Halloween Kiss
- Halloween Kiss Sexy
- Halloween Sun
- Halloween Water Lilly
- Halston
- Halston Couture
- Halston Woman
- Hampton Sun
- Hamptons
- Hamsa
- Hanae
- Hanae Mori
- Hanae Mori Eau De Collection No 1
- Hanae Mori Eau De Collection No 2
- Hanae Mori Eau De Collection No 3
- Hanae Mori Eau De Collection No 4
- Hanae Mori Eau De Collection No 6
- Hanae Mori Eau De Collection No 7
- Hanae Mori Haute Couture
- Hanbury
- Hane Mori
- Hang Ten
- Hannah Montana
- Happy
- Happy Heart
- Happy In Bloom
- Happy Paris
- Happy Pillow
- Happy Spirit
- Happy Spirit Bouquet D'amour
- Happy To Be
- Harajuku Lovers Baby
- Harajuku Lovers G
- Harajuku Lovers G Of The Sea
- Harajuku Lovers Jingle G
- Harajuku Lovers Lil' Angel
- Harajuku Lovers Love
- Harajuku Lovers Music
- Harajuku Lovers Snow Bunnies G
- Harajuku Lovers Snow Bunnies Lil' Angel
- Harajuku Lovers Snow Bunnies Love
- Harajuku Lovers Snow Bunnies Music
- Harajuku Lovers Sunshine Cuties Angel
- Harajuku Lovers Sunshine Cuties Baby
- Harajuku Lovers Sunshine Cuties G
- Harajuku Lovers Sunshine Cuties Love
- Harajuku Lovers Sunshine Cuties Music
- Harajuku Lovers Super G
- Harajuku Lovers Wicked Style Baby
- Harajuku Lovers Wicked Style G
- Harajuku Lovers Wicked Style Lil' Angel
- Harajuku Lovers Wicked Style Love
- Harajuku Lovers Wicked Style Music
- Hard Candy
- Hard Leather
- Harley Davidson
- Harmattan
- Harrods
- Harrods Amber
- Harrods Oud
- Harrods Rose
- Harve Benard
- Harvey Prince
- Haute Voltige
- Havana
- Head Over Heels
- Healing Garden Waters Sheer Passion
- Health & Beauty Focus
- Heartbreaker
- Heaven
- Heaven Sent
- Heaven Sent Vanilla
- Heavenly
- Heidi Klum
- Helene
- Heliotrope
- Heliotrope Blanc
- Hello Kitty
- Helmut Lang
- Her Golden Secret
- Her Majesty
- Her Money
- Her Secret
- Herat
- Herb Alpert
- Hermes
- Herve Leger
- Heure Exquise
- Hexy
- Hidden Fantasy
- High School Musical
- High School Musical 3
- Hilary Duff
- Himalaya
- Hip
- Hiris
- Hiroko Koshino
- Histoire D'amour
- Histoire D'amour 2
- Histoire D'amour Cherie
- Histoire D'eau
- Histoire D'eau Amethyste
- Hodo
- Hollister
- Hollister California
- Hollister Malaia
- Hollywood
- Hollywood Star
- Hot
- Hot Always
- Hot Bill Blass
- Hot Couture
- Hot Couture White
- Hot Gold
- Houbigant
- Hugh Parsons
- Hugo
- Hugo Boss
- Hugo Deep Red
- Hugo Xx
- Hyacinth
- Hypnose
- Hypnose Senses
- Hypnotic Poison
- Hypnotic Poison Eau Secrete
- Hypnotic Poison Eau Sensuelle
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History and background of Adidas. In 1925, in a small German village, the world got it's first taste of Adidas. It was there, in a village by the name of Herzogenaurach, located 12 miles to the north and the west of Nuremberg, that those simple three stripes were brought to life by adidas' founder, Adolf "Adi" Dassler. Adi created adidas after realizing the need for performance athletic shoes. Read more about Adidas
More Adidas fragrancesfor Women: Adidas Moves , Adidas Floral Dream , Adidas Natural Vitality , Adidas Pure Lightness , Adidas Fresh Escape , more
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First of all, FOURTEEN players. Damn, that's a lot of orders to manage. Actually, was there a larger forumfight before? I'm guessing Assault on Goatse Bunker had more players, but idunno actual numbers...
Moving on:
The cavalry moves to the right, preparing to take action later.
Majisto and Gallikronn (mgb519)
Gallikronn swoops to battle, but he's out of firing range. Meanwhile, Majisto cast a shockwave in the middle of the undead infantry, to 'clear some path'.
Ezra von Bragstein (Rev.Sylvanus)
The abominations charge into action! Gallikronn fires on Rot Walker, but the damage is insufficient. While none of the rotting hulks reach into melee range, RW manage to fire a bolt of posion that hits a runeknight (-1 hp). They're backed by corruptors who are just barely out of reach.
Ezra joins the fight after fumbling his heroic feat, and fires his poison scepter (ur: 3, 2d6 damage, useable in cc/6inch range) at a knight, sadly the damage is soaked up by the timely reaction of Apollyon, who casts a barrier spell.
The Necrotitan ominously begins to walk towards the fray.
And here comes a fuckup from my part. Rev, the Doom Wailer was MIA this round because it had no crew/units assigned to it tow it closer to the fight. To compensate this, I'm giving you an almighty benny, which you may spend of summoning crewmen if you wish to do so. Sorry, my bad.
Arthel Wolfsbane (heavyfishcannon)
Arthel engages Rot Walker, no damage is dealt. The Corruptors fire a hail of toxins at the soldiers, killing two, and losing on CC during the process because it critfails on the skillcheck and it explodes in its face.
The crossbowmen back the infantry up and break off 1 hp from the RW.
The Storm Titan follows the crossbowmen. 'Xalen, take my Löwenguard, they're yours to command!' says Arthel, donating some troops to the lone knight.
Xalen (Bragallot)
Xalen advances forward (the Löwenguard following in tandem), and begins to cast some sort of spell...
Suddenly, the trolley cart pusher starts to act on its own...
... and rams the deadly device into the dreadknights!
3 out of 5 are obliterated after the bizarre action. 'wot happand?' the puzzled troll wonders.
Xalen revels in the havoc he had caused, and in a way that channels Deadlock he builds up some surplus energies from the destruction.
'Beaky' (Robot Monkey)
Beaky calls forth a fireblast!
A pillar of fire emerges beneath the runeknights, killing the on that got poisoned, and wounding Apollyon (-1 hp).
Liana (Scratch)
Liana gives some archery training to the crossbowmen, giving them +4inches of range, which means... sniping time!
Rot Walker takes a ridiculous amount of damage (28 points), which is more than enough to overkill it, and we know what's going to happen...
Whilst Arthel, CG and Ezra survive the explosion, RW still takes 3 corruptors and 1 swordsman with it to the afterlife.
After that Liana's troops advance.
Valeera Silverdream
The elves pause and wait for a better time to strike, all but Valeera, who calls forth the powers of nature to fight against evil.
Her summons are successful, causing a line of thorny foliage to sprout in front of the Dark Horde, which doubles as living barbed wire (1d6 damage to any unit crossing it).
Drakhirri Cytheran
The lord and his longblades move to combat, preparing for counterattacks/feats.
Gragh the Bone Behemoth Predator
Gragh orders his troops to march forward, giving them +2 inches of movement, then the large horde of undead begin to relentlessly push forward.
Grok Steelhide Zupponn
The trolley cart tries to make-up for his mind controlled shenanigans...
... by getting rid of the greenery, doubling the cart as a makeshift lawnmower, with surprising success! Grok gives further movement to the operator via feat.
Then, led by the cart, the orks start to move towards the siege line.
The other trolls move out as well.
Ferdinand von Bragstein Silent-sigfig
Ferdinand and the engineer combine their engineering prowess and create...
The second death machine or the first armored car on Medivo? You decide.
It demonstrates its use by blasting apart the front of the trolley cart.
Which is then completely destroyed by cannonfire.
Blaze Ironbreaker - lawmaster
Blaze lends the warmachine to von B, then moves with all of his troops forward. Miners burrow and tunnel underground.
Black Centurion - Pwnerade
The forces advance into the fray!
Meanwhile, the Amplifier in the Hold is starting to power up...
Overwatch and kills:
Rev. Sylvanus - 7
Bragallot - 3
Robot Monkey - 1
Scratch - 1
Send orders for turn 2!


text:
3 Images
Auction Has Concluded
Price Realized: 1,521.00
Price Realized:
Pistol. Cal. 38 Super. S# MHC0107. Stainless Talo Special Edition of only 300. Natural finish frame, gloss slide with laser engraving & gold accents. Left side of slide has "16-Septembre" & banner above an eagle with "El Grito". Left side also has a mans photo & golden banner as well as another banner below eagle. Rear of slide has gold horse on left & "Colt" on right. Right side has 2 banners with Mexican language one of which is saying "1 of 300" (translated). 2 Gold figures in ovals, 1 hooded woman praying, the other an angel with wings, gold bbl. bushing, hammer, mag. release & grip screws. Standard 3 dot sights. Light colored grips that are a mixture of checkering & laser engraving. CONDITION: appears new. UNATTACHED ACCESSORIES: original Colt Custom Shop 2 piece box, shipping sleeve, spare mag., lock & paperwork. (12-1575/NW). MODERN. $750-1000.


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If the simplicity of ASUS' Chromebox is enticing, you'll be glad to hear that you can pick up the miniscule computer very soon. The $179 Chrome OS desktop is now available for pre-order at stores like Amazon, Newegg and TigerDirect, with the first wave of orders due to ship on March 14th. A base system starts out modestly with a 1.4GHz Celeron and 2GB of RAM, although you can splurge for a Core i3 model (the Core i7 variant isn't coming stateside). Just don't expect a completely silent machine -- AnandTech understands that none of the Chromeboxes are fanless, contrary to some expectations. As long that isn't a dealbreaker, though, you can snag ASUS' cheap PC at one of the source links.
- Key specs
- Prices
- Discussions
- Type Small form-factor
- Bundled OS Other
- CPU family Celeron
- Hard drive(s) 16 GB (total)
- Video outputs DisplayPort, HDMI
- Dimensions 4.88 x 4.88 x 1.65 in
- Released 2014-03-31
Google Chrome OS


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Work continues on the Liberty Plaza Project on Municipal Drive in front of the Fishers Town Hall in Fishers, Wednesday November 7, 2012.
- Filed Under
In what is the latest in a long line of accolades, Fishers, has been named, "No. 3" on a list of "America's Friendliest Towns." The list released by Forbes.com and Nextdoor.com, (a private social network for neighborhoods) listed Fishers right behind Sammamish, Wash. and Orinda, Calif.
Home to about 80,000 residents Fishers will begin to take on the look and feel of a traditional city -- a result of the November election where residents were asked to weigh in the community's future. A new mayor will be elected in 2015.
This latest listing is among several naming Fishers including: CNN Money ...


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What does CMIA stand for?
What does CMIA mean? This page is about the various possible meanings of the acronym, abbreviation, shorthand or slang term: CMIA.
We've found a total of 3 definitions for CMIA:
Filter by: Sort by:PopularityAlphabeticallyCategory
Cash Management Improvement Act
Carbonyl Metallo Immuno Assay
Chimei In 144A
Still can't find the acronym definition you were looking for? Use our Power Search technology to look for more unique definitions from across the web!
"CMIA." Abbreviations.com. STANDS4 LLC, 2015. Web. 2 Dec. 2015. <http://www.abbreviations.com/CMIA>.


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Winter Organic Gardening
Wondering what's hot on the winter gardening scene? Carl Grimm from the Metro Natural Gardening program joined us to share a few sizzling tips to keep your winter garden growing healthy and strong.
Organic food gardens are all the rage - now's the time to plant garlic
Take it easy on the turf – no need for weed and feed!
Least-toxic slug control is now the norm
Call Metro Recycling Information at 503-234-3000 for your free copy of Grow Smart Grow Safe
Most Popular


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BRCA1 and BRCA2 mutations exhibit variable penetrance that is likely to be accounted for, in part, by other genetic factors among carriers. However, studies aimed at identifying these factors have been limited in size and statistical power, and have yet to identify any convincingly validated modifiers of the BRCA1 and BRCA2 phenotype. To generate sufficient statistical power to identify modifier genes, the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA) has been established. CIMBA contains about 30 affiliated groups who together have collected DNA and clinical data from approximately 10,000 BRCA1 and 5,000 BRCA2 mutation carriers. Initial efforts by CIMBA to identify modifiers of breast cancer risk for BRCA1 and BRCA2 mutation carriers have focused on validation of common genetic variants previously associated with risk in smaller studies of carriers or unselected breast cancers. Future studies will involve replication of findings from pathway-based and genome-wide association studies in both unselected and familial breast cancer. The identification of genetic modifiers of breast cancer risk for BRCA1 and BRCA2 mutation carriers will lead to an improved understanding of breast cancer and may prove useful for the determination of individualized risk of cancer amongst carriers.
The search for genetic modifiers of BRCA1 and BRCA2
Female carriers of deleterious BRCA1 and BRCA2 mutations are predisposed to high lifetime risks of breast and ovarian cancer. Initial estimates indicated that around 80% of carriers of mutations in BRCA1 and BRCA2 from multiple-case families would develop breast cancer by age 70 [1,2], and genetic counseling is usually carried out on the assumption that penetrance estimates apply to all women. However, a later pooled analysis from population-based studies estimated an average risk by age 70 in this context of 66% in BRCA1 carriers and 45% in BRCA2 carriers [3]. It has also been reported that cancer risks vary by the age at diagnosis and the type of cancer in the index case [3,4]. Such observations are consistent with the more plausible hypothesis that cancer risks in mutation carriers are modified by genetic factors or other risk factors that cluster in families. Segregation analysis has also demonstrated that models that allow for other genes to have a modifying effect on the breast cancer risks conferred by BRCA1 and BRCA2 mutations fit significantly better than models without a modifying component [5]. Further evidence for genetic modifiers arises from studies of risk factors that are themselves influenced by genetic factors. For example, mammographic density that has a strong genetic component [6] has been recently shown in one study to modify the breast cancer risks in BRCA1 and BRCA2 mutation carriers [7].
Although there has been considerable interest in finding genetic modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers, the number of published studies is still fairly modest and has focused around genes involved in a limited number of pathways: detoxification of environmental carcinogens, DNA repair and steroidogenesis. Several studies have evaluated the CAG repeat length polymorphism in the androgen receptor (AR) gene as a modifier of breast cancer risk among mutation carriers. However, the data from different studies are contradictory and no firm conclusions can be drawn as to the magnitude of such an effect, if any [8-11]. Many studies have also evaluated a repeat length polymorphism in AIB1 as a modifier of risk among BRCA1 or BRCA2 mutation carriers. Although an effect of high numbers of repeats on cancer risk in carriers was first reported by Rebbeck and colleagues [12], three large subsequent studies failed to replicate this result [13-15]. RAD51 currently provides the most convincing evidence for the existence of a modifier gene, at least for BRCA2 mutation carriers. Levy-Lahad and colleagues [16] first reported that the -135G>C single nucleotide polymorphism (SNP) in the 5' untranslated region of RAD51 modified the breast cancer risk in BRCA2 carriers and this finding has been substantiated by others [17,18]. The function of the -135G>C SNP in RAD51 is not clear, but it could affect mRNA stability or translational efficiency.
Choosing candidate SNPs or genes to evaluate as modifiers of BRCA1 and BRCA2 suffers from the same problem faced by all candidate-based genetic association studies, namely the poor understanding of the relevant pathways and hence the small a priori likelihood that any of them are true modifiers [19]. These issues may be overcome in the future through the identification of candidate genomic regions associated with breast cancer risk by linkage analyses [20], or more plausibly by the identification of candidate SNPs by adequately powered genome-wide association studies [21]. In addition, the publication of convincingly validated SNPs associated with breast cancer in the general population [22] will provide some new candidates to test as modifiers of breast cancer risk among BRCA1 or BRCA2 mutation carriers. However, since SNPs associated with breast cancer in the general population may not act in the same way among BRCA1 and BRCA2 mutation carriers, pathway-based and perhaps genome-wide association studies in BRCA1 and BRCA2 carriers are also needed.
Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA)
A number of large studies and consortia have been established that aim to identify genetic modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers, including Modifiers and Genetics in Cancer (MAGIC), Epidemiological study of BRCA1 and BRCA2 mutation carriers (EMBRACE), Genetic Modifiers of cancer risk in BRCA1/2 mutation carriers (GEMO), the Kathleen Cuningham Consortium for Research into Familial Breast Cancer (kConFab), the German Consortium for Hereditary Breast and Ovarian Cancer (GCHBOC) and the Breast Cooperative Family Registry (Breast-CFR). However, with current sample sizes of less than 1,500 carriers, none of these groups have adequate power to identify genetic modifiers with confidence. To address this problem, a 'consortium of consortia', the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA), was established in 2005 (see Additional file 1 for a list of current contributors). The operating principles of CIMBA are: CIMBA is open to any group that can contribute genotypic and basic phenotypic and epidemiological risk factor data from at least 100 female BRCA1 and BRCA2 mutation carriers with or without a cancer diagnosis – groups with smaller collections of carriers are encouraged to participate through partnership with a larger group; panels of SNPs for genotyping are selected at face-to-face meetings every six months; only SNPs that show significant associations (arbitrarily set at p < 0.01) with breast cancer risk in carriers, either in the published literature or in data from a member group, or are convincingly identified as associated with breast cancer in the general population, are considered; each group is free to participate, or not, in any round of genotyping; genotyping quality control standards must be followed (>2% duplicates, call rates >95%, no-template controls on every plate and randomized arrangement of affected and unaffected carriers for genotyping); all epidemiological risk factor data and genotyping data from carriers are submitted to the CIMBA data coordinating centre at the University of Cambridge; and genotyping data from participating centers are pooled for analysis. There are currently about 30 groups from North America, Europe and Australia who plan to contribute to some or all of the collaborative CIMBA projects, and collectively they have DNA and minimum required clinical and epidemiological data from more than 10,000 BRCA1 and 5,000 BRCA2 carriers.
Additional file 1. Current contributors to CIMBA
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Statistical considerations
Most association studies are case-control studies, in which genotype frequencies in a series of cases are compared with those in series of controls. The analysis of BRCA1 and BRCA2 modifiers is potentially more complex, because a high proportion of carriers become affected. Thus, modifiers would be expected to influence not just whether a carrier became affected but also the age at diagnosis. More powerful analyses can, therefore, be conducted by treating breast cancer as a survival (age at onset) rather than a simple binary endpoint. An additional problem, however, is introduced by the fact that mutation carriers are mainly ascertained through cancer genetics clinics. In these settings, the first tested individual in a family is usually someone diagnosed with cancer at a relatively young age. Such study designs tend, therefore, to lead to an over-sampling of affected individuals and standard analytical methods like Cox regression may lead to biased estimates of the risk ratios [5]. CIMBA aims to address this potential bias by using standard analytical methods, such as weighted Cox regression, or by analyzing the data within a retrospective likelihood framework [5]. In addition, analyses restricted to incident cases, defined as carriers diagnosed with cancer no more than five years prior to ascertainment, are applied to account in part for ascertainment and possible survival bias. One of the aims of CIMBA is also to further develop the statistical methodology used to analyze such data. Among BRCA1 mutation carriers and at a threshold of p < 0.0001, CIMBA currently has a power of over 80% to detect polymorphisms with minor allele frequencies greater than 10% that confer risk ratios in excess of 1.2 (Table 1). The power is somewhat lower among the current sample of BRCA2 mutation carriers. However, it is still far greater than the power that be achieved by each study individually – at a minor allele frequency of 20% and risk ratio of 1.2, the corresponding power would be <5% for a sample size of approximately 1,000 carriers. Moreover, most of the participating CIMBA centers are actively recruiting carriers, and larger sample sizes are expected in the future.
Table 1. Simulated power (%) to detect a polymorphism with varying minor allele frequency and risk ratio, under a multiplicative model at a significance level 10-4
The identification of convincingly validated modifiers of breast cancer risk for BRCA1 and BRCA2 mutation carriers will help to understand the biology of hereditary breast tumors and, in the case of BRCA1-mutation-associated risk modifiers, will also provide candidate low penetrance genes for 'sporadic' basal cell breast cancers because of their similarity to BRCA1-related breast tumors [23,24]. In the long term it might be possible to include information on genetic modifiers in risk prediction models, to give individualized advice to mutation carriers on individual breast cancer risks, and to have sufficient power to evaluate the risk of other cancers in BRCA1 and BRCA2 mutation carriers.
CIMBA = Consortium of Investigators of Modifiers of BRCA1 and BRCA2; SNP = single nucleotide polymorphism.
Competing interests
The authors declare that they have no competing interests.
Statistical and data management support for CIMBA, and support for EMBRACE and A Antoniou, are provided by Cancer Research UK. The MAGIC Consortium is supported by US Public Health Service grants R01-CA102776, R01-CA08574 and P50-CA83638; EMBRACE by a Cancer Research-UK grant to DF Easton; kConFab by grants from the National Breast Cancer Foundation, the National Health and Medical Research Council (NHMRC, including grants 145684 and 288704) and by the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia, and the Cancer Foundation of Western Australia; INHERIT by the Canadian Institutes of Health Research, and by the Canada Research Chair in Oncogenetics (J Simard); DNA-HEBON Study Netherlands by a grant from the Dutch Cancer Society, NKI 2007-3756; OCGN by Cancer Care Ontario, and OCGN and Susan Neuhausen and Saundra Buys through cooperative agreements with the Northern California Cancer Center, Cancer Care Ontario, The University of Melbourne, Fox Chase Cancer Center, Columbia University and the Huntsman Cancer Institute as part of the Breast Cancer Family Registry (Breast CFR) funded under RFA#CA-95-003; the Helsinki Breast Cancer Study by the Academy of Finland (110663), Finnish Cancer Society, Helsinki University Central Hospital Research Fund and the Sigrid Juselius Fund; the GEMO study by the Programme Hospitalier de Recherche Clinique AOR01082, by Programme Incitatif et Coopératif Génétique et Biologie de Cancer du Sein, Instutut Curie, and by the Association "Le cancer du sein, parlons-en!" Award; The GCHBOC by the German Cancer Aid (grant 107054) and the Center for Molecular Medicine Cologne (grant TV 93 to Rita Schmutzler).
G Chenevix-Trench and A Spurdle and supported by grants from the National Health and Medical Research Council of Australia; FJ Couch by grants from the Breast Cancer Research Foundation (BCRF), US Army Medical Research and Materiel Command (W81XWH-04-1-0588) and the Mayo Clinic Breast Cancer SPORE (P50-CA116201); K Nathanson by a grant from the Breast Cancer Research Foundation; C Szabo by the Susan G Komen Breast Cancer Foundation (BCTR0402923); M Zikan, P Pohlreich and Z Kleibel by the Research Project of the Ministry of Education, Youth and Sports of the Czech Republic (MSM0021620808); J Struewing in part by the Intramural Research Program of the NIH, Division of Cancer Epidemiology and Genetics and the Center for Cancer Research, National Cancer Institute, US Department of Health and Human Services.
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Last month, New York indie rock veterans Nada Surf issued their seventh full-length, The Stars Are Indifferent to Astronomy. With the deluxe physical version of the album came a five-song EP of acoustic album tracks called The Dulcitone Files.
On March 20, the EP will see official release, but you can hear the whole thing now, exclusively on Rdio. Listen to Nada Surf's The Dulcitone Files below.


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|Crawfordville woman arrested with 114.9 grams of marijuana
Wakulla County Sheriff's Office deputies arrested a 23-year-old Crawfordville woman on felony drug charges following a traffic stop on May 5.
Maggie Lee Ogden was charged with possession of more than 20 grams of cannabis and possession of narcotics equipment.
Deputy Stephen Simmons conducted a traffic stop after Ogden threw a lit cigarette out her window that nearly hit his patrol vehicle. Just prior to the traffic stop the suspect threw a second cigarette out of the window. During the stop Deputy Simmons smelled the strong odor of burnt marijuana and observed burnt marijuana cigarettes inside the vehicle.
Ogden handed the deputy two smoking pipes with residue on them and told him about a large bag of marijuana in the trunk of the vehicle. A smaller baggie of marijuana was also discovered in the vehicle search. The marijuana weighed 114.9 grams.
Ogden was given a warning for throwing a lit cigarette out the window. A passenger inside the vehicle was not charged. Deputy Ross Hasty and the WCSO Narcotics Unit also investigated. Ogden posted a $3,000 bond and was released from the Wakulla County Jail.


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Moyle boosts try tally as Hakes ease to big win
Posted: November 01, 2012|
Wessex 0, St Ives 55
KYLE Moyle took his season's try tally in all competitions to 21 as he scored a hat-trick in St Ives' emphatic victory at Exeter-based Wessex, writes Nigel Walrond.
It is nine wins in nine matches for the Hakes now, but they still trail divisional leaders Teignmouth by one point after their points deduction carried over from last season.
St Ives head coach Joff Rowe said: "I am delighted with 55 points and to not give a point away was pleasing, but what must be recognised is that we only performed for half an hour and got into a dogfight, which did not help our performance.
"I have spoken to the players and have challenged them to put that issue right in time for the home match against Crediton on Saturday."
The Hakes were forced into a couple of changes due to work commitments and injuries, with Mark Sherris replacing Tom Nicholas at centre, and South African centre/wing Steve Moorland making his debut off the replacements' bench.
St Ives led after only four minutes, with Neil Corin stealing Wessex line-out ball and setting up a maul, which was driven over for a try by loose-head prop Ben Wheeler.
It was swiftly followed by full back Moyle's first touchdown of the game, and another from lock Richard Humphries following an initial good break by centre Ian Veal.
Former Cornish Pirates fly-half Ceiron Thomas converted, and the Hakes led by 17 points in as many minutes.
Wessex were struggling in all departments, and they conceded three more tries before the break as the hard work of the St Ives forwards and flair of the back line provided further evidence of the influence Thomas and Rob Elloway are having on St Ives' playing style this season.
Veal, winger Rob Rowe and Moyle again, all scored, with Thomas converting one to make it 34-0 at the interval, despite St Ives playing against the wind in the first half.
Wessex started the second period intending to stop the rampant Hakes building a massive score, but five minutes after the restart, Moyle completed his treble, with Thomas adding the extras.
That was Moyle's last contribution as he left the field with a hand injury and was replaced by Tom Murray, with Jacob Ninnes switching to full back.
Wessex began to cause St Ives problems, with their scrum growing stronger and their attacking play building pressure on the Hakes, whose own play deteriorated.
Despite this, flanker Ryan Trudgeon broke through from a line-out in the 49th minute to run 30 metres and touch down under the posts, leaving Thomas with a simple conversion to make it 48-0.
With half an hour left, the Hakes mounted an attack from a poor clearance kick, and quick hands and excellent vision resulted in the try of the game for skipper and hooker Ben Taylor, with Thomas slotting the conversion.
In the final quarter, St Ives lost Corin and Humphries to the sin-bin for off-the-ball incidents, one of which resulted in Wessex prop Lee Mason getting a red card for an alleged punch.
St Ives' seconds are at home to Saltash on Saturday.
St Ives: Moyle, R Rowe, Sherris, Veal, Ninnes, Thomas, Palmer, Wheeler, Taylor (capt), Jenkins, Barber, Humphries, R Trudgeon, S Stevens, Corin. Reps used: T Stevens, Murray, Moorland.
Scorers: St Ives: Wheeler, Moyle (3), Humphries, Veal, R Rowe, Trudgeon, Taylor; Cons: Thomas (5).


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Courage is something we all strive for and often we see people in situations that we are convinced we could never cope with if it happened to us, but the human spirit usually takes over and we do pull through. As Christians we have the added strength of a faith and confidence in God holding us through any crisis we may face and even when we ourselves feel completely overwhelmed and may even struggle with our faith, we have our brothers and sisters in Christ to pray for us and support us. Jesus last commandment to his disciples: 'Love one another as I have loved you, by this shall all people know that you are my disciples.'
In the film 'The Passion of the Christ' the lasting images for me are those when we can see Jesus struggling to find the courage to face his accusers, to accept the uncertainty of his friends and ultimately to face his very violent and drawn out death. Jesus always prayed to his Father, no matter how tough it got, only once asking: 'My God, my God, why have you forsaken me?'
Jesus bravery took him to the cross and the price was paid for our sin so that we might be reconciled to God. Our Father, who wants us to have the courage to face life, knowing that whatever happens, He will hold us close, even when we think He has forsaken us; Jesus died and was brought through that experience to show us that there is eternal life.
That gift of life should help us find the courage to face any headwind that may blow our way. As Paul says in Romans 8: 'If God is for us, who can be against us?…there is nothing in all creation that will ever be able to separate us from the love of God which is ours through Christ Jesus our Lord.'


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From: Beautilicious,
Have you found yourself scowling at the surplus of school kids on the streets this week? Envious of their youthful spirit and carefree lifestyle you think to yourself: "shouldn't they be in school?" Not this week. It's half term, the one week between summer holidays and Christmas when stressed out teens get to escape the pressures of schoolwork, wake up late and generally 'chill out man' – kids are still saying that, right?
We know what you're thinking: the lucky things. We thought it too. But then we thought a little more about the life of the average teen, and unearthed a few of our own painful, teenage memories. We might not be entitled to half term any more but we're older, wiser and in many ways a lot more relaxed. So to help anxious teens across the country 'chill' this half term, we've put together this list of beauty secrets we wish we'd known when we were their age.
OK, this one we did know but we still didn't listen. Teenage skin is prone to all kinds of eruptions. Young and naive, when we were teens we didn't care what caused them or how to treat them - we just wanted them gone, fast. Squeezing is quick, sometimes effective and, we'll admit it, satisfying. It's also very unhygienic and can spread the infection turning a zit into a break out. We learned the hard way with bucket-loads of concealer and many a Friday night spent watching Top of the Pops, too embarrassed to go out. If only we'd known...
When you're a teenager nothing seems more childish than tangly, knotty hair. We wanted ours to be sleek and shiny and that's why conditioner became our best friend – that and the fact our real best friend stole our boyfriend. Well, conditioner turned out to be a tricky mate as well. If only someone had told us that as nice as it might smell and as soft as it makes your tresses it should only be used on the ends of hair. Conditioner on your roots will only lead to one thing. Grease – and most of us had enough of that going on already.
From bra shopping with your mum, to your first experience of heart-break, adolescence is full of pain. But the most difficult and painful experience of our teenage years? Eyebrow tweezing for the first time. We were expecting it to hurt a little, but no one warned us how difficult eyebrow shaping can be. In our attempts to even things out we ended up with brows that were thin and patchy - not very Kate Middleton. If only we'd known the golden rules of eyebrow shaping: stick to your natural arch, never pluck from above and if in doubt call in a professional. We're so glad we've got Shavata on speed dial these days.
This is one we still struggle with when times get tight. Having your hair coloured professionally can be expensive, but if you fancy a change it really is worth it. Throughout our teens we witnessed many a DIY dye disaster and from the looks of things today they're still all the rage. We wish we could go back and tell ourselves that, firstly: green hair is not a good idea.And secondly: over dying hair can seriously dry it out leading to long-term damage. If we could go back we'd tell our teenage selves to be super nice to our hair. To go for regular trims, be careful not to over-wash and always use a heat protection spray. Which brings us on to our final piece of Wahanda wisdom...
They say as you get older you're destined to turn into your mother. we've spent years denying it, but maybe it's true. If there was only one thing we could go back and tell our younger selves it would be the same thing our mums told us time and again: "look after yourself". Of course we'd be doing it from a selfish point of view. Only now that we've grown up a bit have we realised just how important it is to look after your skin, teeth and diet from a young age. If we could go back in time we'd slather our younger selves in SPF50, fill our lunch box with fruit and brush our teeth five times a day. Then we'd jump forward a few years, 'invent' the internet and become millionaires! Now where can we find a time machine?
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How to eat your way to better hair
Spa of the week: Lifehouse Spa and Hotel
Pharrell Williams' beauty secrets and other male friendly products
The Good Spa Guide announce 2013 winners
Spa of the week: Samsara Mind and Body
Something for the weekend: homemade beauty remedies
Wahanda news: Stylist skincare awards announce winners
Halloween hair and makeup inspiration from the experts
Wahanda loves: hidden gems in the city
Spa of the week: Chuan Spa at The Langham
Something for the weekend: make the most of your extra hour
Wahanda guide: get fit with Strictly
Salon of the week: Jade Angel at Czaro
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Spa of the week: Spa Verta at Hotel Verta
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Something for the weekend: DIY Dip Dye by Bleach London
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Tattoo removal searches soar in UK weeks after Cheryl Cole unveils her latest bodyart
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Tried and tested: Micellar water
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Something for the weekend: ESPA Optimal Skin ProSerum - the facial in a bottle
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Elemis launch in seven new hotel spas
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Lock up your makeup; men's grooming is on the rise
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App-solutely fabulous running plans for all levels
Tried and tested: creepy crawly face creams
Spa of the week: The Spa in Dolphin Square
After the birth of a new Royal heir, why are all eyes on Kate's 'mum tum'?
Salon of the week: Sergio Giannasso
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Spas of the week: the most exotic venues and treatments on UK soil
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Spa of the week: Massimo Giglio, fanatical about hair
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Tried and tested: our verdict on the Time Bomb range
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Tried and tested: ISHTA Yoga at Evolve Wellness Centre
Wahanda loves: lunch break massages
Wahanda guide: simple and stylish festival hair
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Wahanda news: beauty looks from this week's GLAMOUR awards
Wahanda guide: top five luxury pools for summer
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Wahanda guide: how to get an expert pedicure at home
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Best in show: favourite floral treatments
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Spa of the week: Thai Square Spa City
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Spa of the week: Greenwoods Hotel Spa and Retreat
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Spa of the week: Thai Lamoon Therapy
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Tried and tested: our verdict on Dielle Nail Colour
Spa of the week: The Spa at Pennyhill Park Hotel
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Wahanda's spring warm up: massages
Wahanda's spring warm up: self-tanning
Wahanda's spring warm up: spring spa days
Wahanda's spring warm up: detox time
Wahanda news: UK's first specialist maternity retreat to open this summer
Wahanda's spring warm up: nails
Tried and tested: Cucumba Electric File
Wahanda news: revolutionary fabric conditioner promises softer skin
Spa of the week: Utopia Spa at Alexander House Hotel
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Spa of the week: Adamina Spa of Kensington
Wahanda news: Diptyque launches daffodil candle in time for St David's Day
Wahanda guide: fitness myths busted
Wahanda news: Liberty open beauty pharmacy
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Spa of the week: Chelsea Day Spa Boutique, Wandsworth
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Wahanda news: Matthew Williamson brings the braid back at LFW
Wahanda news: Cucumba and Style Icon host fashion & beauty evening
Wahanda loves: healthy alternatives for national chip week
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Wahanda guide: what to give up for Lent
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Spa of the week: The Dorchester Spa
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Wahanda interview: Mary Greenwell talks to us about her latest perfume
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Spa of the week: K Spa at K West Hotel
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Wahanda loves: overnight beauty products
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Wahanda guide: eat your way to a good night's sleep
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Spa of the week: The Malvern Spa
Wahanda guide: how to beat a cold in 24 hours
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Tried and tested: Decleor aroma mosaic facial
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Wahanda loves: treats for your feet
Wahanda news: Selfridges launches Silence Room
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Wahanda guide: how to fulfill New Year's Resolutions
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Wahanda loves: healthy New Year's resolutions
Wahanda guide: New Year's Eve party survival
Wahanda loves: The Detox Kitchen
Wahanda news: women use three times more make up at Christmas
Wahanda loves: Christmas gifts for YOU
Wahanda news: hooray we've reached 1000 bookable venues on site
Wahanda news: Sanctuary Spa to ring in new year with Sleep Spa Day
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Wahanda guide: avoid gaining weight this Christmas
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Wahanda news: new anti-ageing elixir is out of this world
Wahanda guide: healthy Christmas cocktail swaps
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Wahanda loves: top five books to give and receive this Christmas
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Wahanda news: Mandara Spa offers festive season LBD package
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Wahanda loves: quirky gift ideas
Wahanda loves: Christmas presents we want
Wahanda news: Mottram Hall plans £5.5m make over for 2013
Wahanda loves: Christmas beauty gift sets
Wahanda guide: Party-proof make up that will last
Wahanda loves: long lasting treatments to get you through party season
Wahanda loves: Dr LeWinn's cosmeceutical skincare
Wahanda guide: how to walk in heels
Wahanda loves: party season nails
Wahanda guide: how to do grown up glitter
Wahanda loves: icy winter treatments
Wahanda guide: how to smile for the camera
Wahanda loves: winter warming beauty treatments
Tried and tested: Keratin Blow Out at Joe's Salon
Wahanda loves: top three beauty hotspots in Fulham
Wahanda guide: easy party season hair fixes
Wahanda loves: gold standard beauty treatments
Wahanda guide: expert party hair
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Wahanda news: Boutique Sport and Yotopia introduce hot Pilates
Wahanda guide: how to have a stress-free christmas
Wahanda news: Sanctuary Spa Bristol celebrates its second birthday
Wahanda loves: party season handbag beauty essentials
Wahanda news: D&G makeup launches Christmas collection
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Wahanda loves: try something new this month
Wahanda news: exercise reduces depression in cancer patients
Wahanda loves: Halloween make unders
Wahanda guide: how to do Halloween makeup
Wahanda guide: take the fear out of scary spa treats
Wahanda guide: using your extra hour wisely
Wahanda tried and tested: Elemis Absolute Spa Ritual at Anesis Spa
Spa of the week: The Laboratory Spa and Health Club
Wahanda guide: homemade facemasks
Wahanda guide: how to cope when the clocks go back
Wahanda guide: winter warming herbal teas
Wahanda news: Anesis spa celebrate IPL launch on This Morning
Wahanda news: floating spa to open in Amsterdam in 2014
Wahanda guide: turn your bathroom into a spa
Wahanda news: John Bell & Croyden welcome 16 new brands
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Wahanda news: 9/10 of us aren't getting enough vitamin D
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Wahanda guide: understanding cosmetic ingredients
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Wahanda guide: office health tips
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Wahanda loves: five star treatments
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Spa of the week: Amanda Lacey clinic
Wahanda news: October is Breast Cancer Awareness Month
Wahanda loves: full moon beauty
Wahanda guide: makeover your makeup bag for autumn/winter
Wahanda guide: how to calm date-night nerves
Wahanda guide: pre-date pampering
Wahanda loves: autumn 2012 nail trends
Tried and tested: our verdict on five hand creams
Wahanda news: spa-bar opens in East London
Wahanda loves: beauty venues to visit on a day out
Wahanda loves: escape the city in under an hour
Wahanda news: get A-list eyebrows at Shavata Brow Studios
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Wahanda loves: products and treatments that make life easier
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Spa of the week: Patrick Ludde
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Tried and tested: Indiba Deep Beauty
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Wahanda loves: new season supplements
Wahanda news: get the perfect work-life balance
Wahanda news: The Caledonian Hotel to open UK's first Guerlain spa
Wahanda guide: how to perfect your pose
Wahanda loves: catwalk hair and beauty trends from New York Fashion Week
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Wahanda news: Topshop expands beauty department
Wahanda loves: back to school spa days
Spa of the week: Pure Beauty, Fulham
Wahanda guide: fixing teenage beauty problems


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- Filed Under
Republican lawmakers are putting the final touches on legislation that would delay the implementation of Common Core education standards and its companion test in Tennessee, perhaps setting the stage for the type of fight playing out in statehouses across the country.
Around a dozen House Republicans, according to Rep. Rick Womick, R-Rockvale, are united behind a bill to take a pause from the controversial curriculum - for up to three or four years - and separate legislation to delay its corresponding test called the Partnership for Assessment of Readiness for College and Careers.
With a ...


text:
We found the following items in Wisconsin.
Upcoming Events
From the Magazine
A new anthology of short fiction from the University of Wisconsin Press explores the breadth of stories that women of color have to tell.
Sam Savage wrote for decades and eventually gave up completely before his debut novel was published when he was sixty-five. Now he's an international best-selling author with a third novel, Glass, published by Coffee House Press, and one simple message for all of us: Art can save you.


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Dear Readers,
We want to make you aware that Newcastle Investment Corp. announced today that the spinoff of New Media Investment Group Inc. was successfully completed.
The Cape Cod Times' parent company, Local Media Group, is a wholly owned subsidiary of this newly public company, New Media Investment Group. We will continue to be an integral part of the community, as we have been for so many years. And we will continue to bring the community rich local news and information and remain the center of the conversation among businesses and citizens.
In addition to our newspaper, New Media Investment Group's portfolio consists of 435 community publications, more than 350 related websites and a digital marketing services business. New Media Investment Group is the largest publisher of locally based print and online media in the U.S. as measured by the number of daily publications serving 338 markets across 24 states.
Starting today, New Media Investment Group will begin trading on the New York Stock Exchange under the symbol "NEWM."
You can learn more about New Media Investment Group at www.newmediainv.com.
Peter Meyer
President and Publisher
Location, ST | website.com


text:
Gov. Bobby Jindal has named several locals to state boards.
- Filed Under
A number of local people have been named to several boards by Gov. Bobby Jindal.
Jindal on Friday announced five appointments to the Caddo Levee District, which is responsible for maintaining the integrity of the levees and maintaining the levee drainage system within Caddo Parish.
The new members are Patrick Harrison, of Shreveport, resident of Sound Fighter Systems; Kandi Moore, of Belcher, a nurse at Specialist Hospital Shreveport; Gary Procell, of Shreveport, president and founder of Procell Allstate Insurance; Helen Godfrey Smith, of Gilliam, president and CEO of Shreveport ...


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From Property Valuations to Real Estate, Hotfrog showcases an extensive range of businesses in the Brisbane City North region. If you want a more specific search, browse by suburb using the left navigation menu. We make your search easier.
Be chosen by customers first with your ad at the top of pages like this.
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JDMA Property Consulting and Valuations provides independent property valuations in the Greater Brisbane area. We assist our clients to make wise i…
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Quinlans is a small property valuation and consultancy business with over 45 years experience. We are registered to undertake property valuations in both Queensland and New South Wales. Quinlans valuation services …
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Minnelex Minnelex provides geological consulting services to the exploration industry. Most of its services involve property valuations and the preparation of independent geological reports.
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Australian Valuers formerly Ray White Valuers (Brisbane) provides independent property valuations and consultancy relating to all property types including residential, commercial, specialised and general purpose through…
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Company profile of myRPData which is a brand of RP Data Property Reports. Based in Brisbane with offices throughout Australia we are Australia's number one provider of property information
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'Loose lips'? No worries
The things I didn't do in relation to my recent trip while my house stood empty of people:
I didn't let people know I was gone. Not even the renters in the garage apartment.
I didn't cut off mail delivery or paper delivery.
I didn't move my pickup truck, which is my usual mode of transportation.
I didn't take a taxi to the airport.
I very quietly made other arrangements with good people.
Silly? Perhaps. But I have no regrets.
I have lived long enough to know that people talk, and long enough to know that "loose lips sinks ships."
Alva Z. Albright, Alexandria
On chronic pain
September was Pain Awareness Month to raise awareness of the 116 million Americans who suffer from chronic pain in the United States, including millions of adults with debilitating conditions like chronic lower back pain, fibromyalgia and arthritis. Chronic pain affects more Americans than diabetes, heart disease and cancer treatment combined.
According to the Institute of Pain, the suffering of chronic pain by adults in this country costs the nation up to $500 billion each year in added health-care expenses and lost productivity, including billions in state Medicaid expenditures.
Those with chronic pain, like arthritis patients, suffer a type of "quiet discrimination" because their condition is misunderstood by family, employers, co-workers and some health-care providers; and they often are under-treated due to significant barriers to adequate pain care that exist.
Due to the changes in our national health-care delivery system, it is more important than ever that patients suffering from chronic pain have access to accurate diagnoses and effective and immediate treatment from a well-informed primary-care provider who is familiar with the causes of and contributing factors that influence pain.
Effective treatment of pain can improve the lives of chronic pain sufferers in Louisiana and nationwide and reduce the economic burden to our state and nation.
Karen Kennedy, Arthritis Association of Louisiana, Baton Rouge, www.aaola.org
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Letters to the editor on topics of community interest are welcome.
Letters may be up to 200 words long and should be original to the sender.
All letters are subject to editing for length, grammar, style and libel.
Email: email@example.com.
Mail: Your Mail, c/o The Town Talk, Box 7558, 1201 Third St. Alexandria LA 71306.


text: I would vote for the Gossen DigiPro F, it takes a single AA battery and unlike the Sekonic 308 can be set to aperture or shutter priority. The Sekonic can only be used as a shutter priority meter, so you can find yourself scrolling through the reading until you get to the aperture you want to use. As a reflectance meter you can also rotate the head of the Gossen to face the subject, on the Sekonic you have to turn the display away from you each time you take a reading. Small things, but they help if you need to work quickly.


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Business of the Year -Kennesaw Business Association, 2011. Best Steak -Kennesaw Patch reader survey and Best Wings -Wing & Rock Festival. Featuring covered patio dining; curbside to-go and full-service catering.
We're committed to extending hospitality beyond the restaurant and into the Kennesaw community.
>> Tailgate Feast MENU <<
Contact Information
745 Chastain Rd NW
Kennesaw, GA 30144
Phone: 770.428.2055
Reservations | Catering | Curbside to-go
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General inquiries, please click here.
Catering assistance by email.
11am-10pm Sunday – Thursday
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Thanksgiving, 11am-5pm >>MENU<<
Christmas Eve, 11am-4pm
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Super polite and wonderful staff. Server was awesome, service was quick and everything was fresh. My meal was tasty…I decree that everyone needs to get their croissants, at the very least! Nice ambiance, cool place. I will go back, and soon! – UrbanspoonKat F., Atlanta, GA
I eat out almost every night of the week and California Dreaming has been consistently fresh, very flavorful, and the service has been nothing but the best. Everything I have ever tried has lived up to my expectations. I have never seen a house salad like California Dreamings. Make sure it is the first thing you try along with the nachos. Try the one in Duluth it is just as great. – UrbanspoonLilly L., Atlanta, GA


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Costa Rica or Nicaragua
Ceramic, pigment; H. 23 7/16 in. (58.7 cm)
The Michael C. Rockefeller Memorial Collection, Bequest of Nelson A. Rockefeller, 1979 (1979.206.378a,b)
The flare-footed, spherical bowl of this ceramic censer is enhanced, in silhouette, by the flamboyance of its chimney. Textured, appliqué bands encircle and emphasize the tall smoothness of the chimney. On the perforated cap rests an elaborate crested crocodilian. Smoke from the incense that was burned in the bowl escaped through the holes of the cap and from openings in the animal's body. The rhythmical texture of the appliqué visually unites it with the surface of the creature's body where the nubby portions are taken to represent the scutes of the reptile. Both textured appliqués and scutes are surfaced in white. The spiky crest that surrounds the head is customarily found in incensarios of this period. Crocodilians frequently appear in Costa Rican art, strongly suggesting the supernatural import of these creatures in ancient times.


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SACRAMENTO — Whether forced treatment helps those with severe mental illness or violates their rights is at the heart of the debate over a bill passed Thursday by the Assembly.
AB1569 extends until 2017 a law that allows courts to mandate treatment for people with severe mental illness if they have history of violence or hospitalization. Laura's Law, which passed in 2002, is set to expire next year.
California's 58 counties are allowed to decide for themselves whether to implement the law. Only one, Nevada County, has done so. Counties are limited in how they can fund Laura's Law programs and cannot divert money from voluntary programs.
Assemblyman Mike Allen, D- Santa Rosa, said he sponsored the bill granting the extension because counties need to be able to compel people with severe and persistent mental illness to accept help.
"Laura's Law is simply a tool to provide this mentally ill population a needed treatment plan," he said during debate on the Assembly floor.


text:
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Lizzie Lee
Lizzie Lee graduated from Peachtree Ridge High School in the top 1% of her graduating class of over 800 students. Entering her senior year at Georgia Institute of Technology, she is currently working on her Bachelors of Science in Industrial Engineering along with a minor in Korean. She has maintained a competitive 3.9 GPA while balancing her rigorous course...View profile
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Nari Lee is the salutatorian of Chattahoochee High School and was awarded the National Merit Scholarship, and first prize in the France-Atlanta 2012 Humanitarian Contest.View profile
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Priscilla Kim graduated from Johns Creek High School as the valedictorian of the Class of 2014. She plans to attend the University of Pennsylvania this fall and has accepted an invitation to join the Vagelos Scholars Program in the Molecular Life Sciences, a program offered to select students from the top 15% of all applicants.View profile
Michael Park
Michael Park is a graduate of the University of Georgia and is the only Tutelage Academy staff member who can recite the ABC's backwards in under five seconds! Before Tutelage, Michael served as Project Manager, Product Brand Manager, and Co-Executive Director in multiple companies in the IT healthcare field, and a non-profit company called Vida.View profile
Our Method
Ever wonder how world class athletes and professionals train? Two words. Deliberate practice. We use a systematic 6 step process to help guide develop students abilities in many areas. See our article on deliberate practice featured in the blog, How to Learn.
Learn Smarter with a Holistic Approach
Student Centric Approach
Studies show that students in a student centric environment outperform teacher-centric environments by a large degree.
A Positive
Our mentors are handpicked, positive, young, self-motivated leaders.
Build Personal
We focus on personal habits that are the most important factors in student success.
What Students Say
- The teachers at Tutelage provide me the most beneficial solutions to the subjects that I struggle with periodically. They make studying for the SAT and other subjects simple and entertaining. It is nice to learn something new every week in a comfortable environment.Josh Min480 point increase in SAT
- The teachers at Tutelage know what they are doing. They focus on the areas you need help with and overall come up with a solution that fits you. The variety of material offered by Tutelage allowed me to improve my scores within the first two classes of enrollment.Amir Azmi380 Point Increase on SAT
- The test strategies that the Tutelage teachers have taught me have not only improved my overall test score but also the way I have studied independently. These teachers use individual statistics to help strengthen my weak points through tips and daily practice.Tiffany Tsou380 point increase in SAT
- "Tutelage really helped me bring great results with my score in a quick period time. Tutelage VIP!"TK YeoSAT increase of 710 pts
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"Obstacles are those frightful things you see when you take your eyes off the goal"
-Henry Ford


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Editorial: State has big to-do list for 2014
Tax relief, education and more
6:58 PM, Dec. 28, 2013
The big events from 2013 leave plenty of loose ends that top 2014's to-do list. Here's a look at issues that impacted New York and the Lower Hudson Valley in 2013, and what more needs to happen in
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Agriculture and Food Security
Excerpt from the Saanich Vision Statement of the Official Community Plan.
Join the Agriculture & Food Security Task Force
The District of Saanich is accepting applications from individuals wishing to participate on a Task Force to guide and contribute to the development of a comprehensive Agriculture and Food Security Plan for Saanich. Click here for more information and to download the application.
About Agriculture & Food Security
Visit here first to learn about the history and basics of Agriculture and Food Security in Saanich.
Connecting People to local Food
There are a variety of ways to find and buy locally grown food. Click here to find farmers markets, the "Farm Fresh" directory of local farms and other links for local products.
Current Policies & Regulations
The Social Well-Being section of Saanich's Official Community Plan promotes community values that protect agricultural land and food security.
Peninsula & Area Agricultural Commission
An advisory committee whose mandate is to advise the municipalities of Central Saanich, North Saanich, Saanich, Sidney and Metchosin on matters involving agriculture.
Community Gardens can offer residents a place to socialize; a place to get fresh air and exercise; a place to feel accomplishment; and most importantly a place to grow their own food.
Protection and conservation of natural ecosystems on our farmland and in our urban gardens strengthens the capacity of the land and its agricultural production.
This page provides sources and ideas to encourage agriculture within Saanich's urban communities and increase the acceptance of agriculture within Saanich's urban areas.
Communities in Harvest Program
Communities in Harvest is a residential program to educate, support and engage residents in backyard food growing to create a culture that fosters local food production in our region.
See Also
Chickens are now permitted in residential backyards in Saanich. Owners must register their flocks by following the links within.
The purpose of the Healthy Saanich Advisory Committee is to promote effective communication, engagement and collaboration between the Municipality and its citizens.


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AboutThe short list: Girl, Denmark, Singel, Danish, 17/08-1982, 2x tattoo´s
My oldest big brother past away the 29-07-09
You will always be in my heart i love you.
I love.
The color Pink and i relly like avi art so if you want to be nice to me pleeas drav me if you like to drawe me pleas write me a PM and i will tip you for it.
Help me bump
Trying to get 100
Viewing 12 of 16 friends
It just littel me
Viewing 10 of 20 comments.