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|Star Trek - Original Series The one that started it all...
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|October 23 2013, 06:08 AM
Location: The Enterprise's Restroom
Commodores in command of Starships?
Yet, "The Doomsday Machine" and "The Ultimate Computer" present us with Commodores who are seemingly in actual regular command of their ships: Commodore Decker of the USS Constellation, and Commodore Wesley of the USS Lexington.
We might excuse Wesley as being another unique situation, as they're testing out the capabilities of the M-5 in a battle scenario. Maybe he's only the temporary commander of the Lexington for the purposes of that particular test run.
On the other hand, the script of "The Doomsday Machine" basically assumes that Decker is the proper master of Constellation, that he is the captain except for his rank. Unless we are to assume that the Constellation's own captain died and Decker (like Stocker) simply happened to be on-board and took command?
What's the real-life protocol in these situations? Was it ever common in the real navy for a ship's regular "captain" to actually be a commodore?
|October 23 2013, 06:12 AM
Location: "Who are you?"
Re: Commodores in command of Starships?
A life is like a garden. Perfect moments can be had, but not preserved, except in memory. LLAP Leonard Nimoy (1931-2015)
|October 23 2013, 06:21 AM
Fleet Admiral
Re: Commodores in command of Starships?
Stocker was a commodore who was used to desk duty (commanding starbases and things like that). Other commodores, like Decker and Wesley, were starship captains in their own right.
"If the world was perfect, it wouldn't be." - Yogi Berra
|October 23 2013, 09:25 AM
Vice Admiral
Location: No matter where you go, there you are.
Re: Commodores in command of Starships?
"The real and lasting victories are those of peace, and not of war." - Emerson
|October 23 2013, 10:27 AM
Location: The Enterprise's Restroom
Re: Commodores in command of Starships?
I guess they chose not to do that because 'Admiral Kirk' had a more impressive ring to it than 'Commodore Kirk'.
|October 23 2013, 10:41 AM
Vice Admiral
Location: No matter where you go, there you are.
Re: Commodores in command of Starships?
"The real and lasting victories are those of peace, and not of war." - Emerson
|October 23 2013, 11:18 AM
Location: The Enterprise's Restroom
Re: Commodores in command of Starships?
|October 23 2013, 02:57 PM
Fleet Captain
Location: Clinton, OH
Re: Commodores in command of Starships?
Commodore is a military rank used in many navies that is superior to a navy captain, but below a rear admiral. Non-English-speaking nations often use the rank of flotilla admiral or counter admiral as an equivalent, although the latter may also correspond to rear admiral.
Traditionally, "commodore" is the title for any officer assigned to command more than one ship at a time, even temporarily, much as "captain" is the traditional title for the commanding officer of a single ship even if the officer's official title in the service is a lower rank. As an official rank, a commodore typically commands a flotilla or squadron of ships as part of a larger task force or naval fleet commanded by an admiral.
It is often regarded as a one-star rank with a NATO code of OF-6 (which is known in the U.S. as "rear admiral (lower half)"), but whether it is regarded as a flag rank varies between countries.[1]
|October 23 2013, 06:26 PM
Re: Commodores in command of Starships?
Decker does indeed seem to be CO of Constellation and no other vessels. Wesley seems to be Lexington's CO as well as task force commander.
My usual pet explanation for the situation is that starships are organized in divisions (or squadrons if you prefer) of three or four ships. The captain of one of them has the rank of commodore and is division commander on paper, but in practice the ships are spread all over space on different assignments so the division command doesn't come into play very often. Wesley could be an example of the division commander actually taking command, but an oddity is that he wears the Starbase/Starfleet Command badge.
Side note: Decker would not be "master" of Constellation, that term applies to captains of merchant ships.
The early US Navy, small and lean, used the "second class" commodores extensively. Como. Preble, who made a great reputation for the USN in the Barbary Campaign, was captain of Constitution as well as squadron commander. Thomas Truxtun, the "star" captain of the Quasi-War with France, had refused the command because the Navy Department wouldn't assign a captain under him for his flagship.
There was a time after the Civil War when a few USN commodores (a permanent one-star rank, by then) were assigned command of large warships, without an associated squadron command. This was mostly an aberration caused by the numbers of senior officers created for the war, and after the navy had down-sized in the 1870s it didn't happen any more.
|October 23 2013, 07:08 PM
Location: Melakon's grave
Re: Commodores in command of Starships?
I sort of liked the strangeness (to Americans at least) of Gerry Anderson's Supermarionation series Fireball XL5-- a Colonel is commanding officer of the ship, but the head guy at the Earth base is a Commander with a Lieutenant as his assistant. I don't know if that's patterned after Royal Air Force or what. I adapted Fireball's style into my own fictional universe to keep it from looking too much like a Trek clone.
Dr. Howard, Dr. Fine, Dr. Howard: For duty and humanity!
--Men in Black (1934)
|October 24 2013, 12:13 AM
Re: Commodores in command of Starships?
The only Commodore I know of in the current US Navy is a commander of a submarine squadron. The captain of a submarine is an 0-5 rank (Commander). He is called captain because Navy convention is anyone in charge of a vessel is called captain.
The commodore has the rank of 0-6 captain and is in charge of a submarine squadron.
I don't know for sure but I think if a commodore was on board a boat and the captain was incapable of command the XO would take over command of the vessel not the Commodore. Same goes for admiral/captain aboard an Aircraft Carrier.
|October 24 2013, 12:58 AM
Fleet Captain
Re: Commodores in command of Starships?
|October 24 2013, 02:33 AM
Lieutenant Commander
Location: London, UK
Re: Commodores in command of Starships?
NB. This is disputed by some on this board, as some think the Professor in the episode (a civilian no less) was in command or the normal captain was somewhere else. I don't think there is anything to support that.
"Yeah" - Dredd's (Karl Urban) response to Mama's threat after throwing her down 200 levels...............
|October 24 2013, 02:36 AM
Location: State of Mind
Re: Commodores in command of Starships?
Life is what happens to you while you're busy making other plans: John Lennon
|October 24 2013, 03:35 AM
Location: "Who are you?"
Re: Commodores in command of Starships?
A life is like a garden. Perfect moments can be had, but not preserved, except in memory. LLAP Leonard Nimoy (1931-2015)
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Pre- and Post-Visit: Winter (Grades 6-12)
Students that have spent time preparing for their visit to Glacier National Park get more out of a field trip to the park. Activities post-visit also help to reinforce information learned during the trip.
The following are some of our suggested pre-visit activities, as well as supplementary materials that may aid in preparing for your trip.
Suggested classroom activities from Teacher's Guide
Winter Ecology Teacher's Guide (pdf) - this is a large file and may take time to download
Winter Pack worksheet (pdf) - this worksheet (or a similar version) will be used on your field trip.
Supplementary Materials and Information
Snow Survey References


text:
- Filed Under
Fairfield County Sheriff's office
? A mower, a single shot rifle, a table saw and a miscellaneous hand tools were reported missing from a home along the 6000 block of Indian Run Road, Pleasantville.
The items were reported missing between 12:30 p.m. Saturday and 10:50 a.m. Sunday. The owner reported that a basement window was broken to gain access to the home, according to a sheriff's report. He also reported that a rear glass door was found opened, the report said.
The loss was not estimated.


text:
Gateway tops Canon-McMillan in overtime
TribLIVE Sports Videos
The Gateway varsity girls soccer team upended Canon-McMillan, 2-1, in a shootout Wednesday, and the program will play in the WPIAL semifinals for the first time in its 27-year history.
The fifth-seeded Gators will take on top-seeded Peters Township in the semifinals on Tuesday. Peters Township defeated Hampton, 1-0, on Wednesday.
No. 2 seed Seneca Valley and third-seeded Bethel Park will meet in the other semifinal contest.
The top three teams from Class AAA advance to the PIAA playoffs, and Gateway is guaranteed at least one game beyond the semifinals.
The third-place team will be determined through a consolation game on Nov. 3, but the Gators hope to be involved in the WPIAL title game that same day and already know they will be in the state tournament.
The semifinal winners automatically qualify for states.
Senior forward Carly Seneca scored Gateway's lone goal in regulation against Canon-McMillan, and after both teams played through two overtime periods, Seneca tallied the deciding goal in the shootout.
Seneca has 24 goals this season.
Gateway improved to 16-3-1 with the victory. Canon-McMillan, the 13th seed, was in the quarterfinals after upsetting Penn-Trafford, 3-1, in the first round.
Michael Love is a staff writer with Trib Total Media. He can be reached at 412-388-5825 or at email@example.com.
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text:
LOS ANGELES, Calif. -- The world famous Los Angeles Athletic Club, founded in 1880 and home to the annual Wooden Awards Ceremony, witnessed yet another prestigious event last Sunday as it hosted the "Dave Yanai Tribute Dinner and Silent Auction," honoring the former men's basketball head coach of Cal State Dominguez Hills.
"Tonight was a very special evening for a very special man, as evidenced by the love, admiration, gratitude and respect felt in the capacity-filled room," said CSUDH Athletics Director Patrick Guillen, reflecting on a tremendous night.
"Tonight's incredible event was the culmination of hundreds of hours of work, and I would like to express my deep appreciation to those who worked so tirelessly on this campaign, especially our co-chairs in Henry Ota, John Nojima, Dan Guerrero and Sam Lagana for their leadership, as well as to emcee Rob Fukuzaki, who offered his time and talent in helping make the night one to remember."
Emceed by KABC-7's sports anchor Fukuzaki, with speakers including UCLA Athletics Director Guerrero and ESPN/ABC analyst Steve Lavin, the event gave glimpses into coach Yanai's storied and award-filled coaching history, where guests including family, friends, colleagues, former players and co-workers filled the room with anecdotes about the man who many referred to as "so much more than just a coach."
Beginning with a cocktail hour featuring a vast array of silent auction items, the evening's dinner commenced with Guillen giving a warm welcome, followed by CSUDH VP Sue Borrego saying a few words on behalf of CSUDH President Mildred García, who gave way to Fukuzaki.
The southern California sports anchor icon then proceeded to introduce Lavin, former Toro Nojima and Guerrero, who each gave his personal account of the man who helped teach, mentor and inspire them, with composure, honesty, and caring emerging as common denominators.
Fukuzaki and Guillen followed suit, with Pepperdine's Associate Vice Chancellor and former CSUDH administrator Lagana interjecting with tremendous live auction items, before coach Yanai took the podium.
After thanking Guillen, who spearheaded this night and January 9, the date of the court unveiling, his wife and kids, and parents, Yanai named five individuals who served as mentors in brother Frank, Mas Fukai, Nojima's father, the night's honorary chairman John R. Wooden and Pete Newell, before giving credit and showing appreciation to the guest speakers, as well as his former assistants, trainers and players, many of whom were in the audience.
"Obviously it's a great honor and I'm really humbled by this whole affair," began Yanai, before the dinner. "The main thing for me is my thoughts for the scholarships this night may grant, but I'm so honored about the court naming.
"There are so many players, assistant coaches, boosters, administrators, and people who were my colleagues at CSUDH all these many years, and everyone of them has a piece of this wonderful honor, and when they see my name on the floor, I hope they feel like it's their name because they all have a piece of it.
"I retired four years ago, and you just want to get onto other things that you've put on hold for a number of years like enjoying the grandkids, taking trips with one's wife, golfing and assorted other things. I'm an avid reader and now I can do it at my leisure and am getting the chance to do all the things that I love.
"And I also get a chance to do a little basketball activity," he continued, never quite being able to leave the game that's been so good to him. "I've gone to practices of various college coaching friends of mine and had a chance to critique and see some things that might help them.
"But this is something that I didn't expect and to be honest, I'm really shy about these kinds of things. All I can say is that I'm humbled and honored to have this wonderful thing happen to me, and it's a tremendous honor."
Yanai spent 19 seasons as head coach at CSUDH, where his Toro teams advanced to the 1981, 1987 and 1989 NCAA Tournaments. In addition, he guided the Toros to the 1979 NAIA National Championship Elite EIght after winning the NAIA District III Championship in only his second year in Carson.
Individually, he claimed the 1979 District Coach of the Year, the 1987 NCAA West Region Coach of the Year and two-consecutive CCAA Coach of the Year Awards (1987 and 1988). Yanai also coached 34 All-CCAA Conference, two CCAA Athletes of the Year, eight NCAA All-West Region, two NCAA All-Americans and one NCAA Division II Male Scholar-Athlete of the Year in Nojima, ending his coaching career at CSUDH with 287 of his 401 total wins, the winningest coach in CSUDH men's basketball history.
Part II of the "Dave Yanai" tribute will take place on Saturday, January 9, at 7:00 pm, when the Torodome court will be unveiled in his honor.
Former CSUDH Men's Basketball Coach Dave Yanai Honored at Dinner
LOS ANGELES, Calif. -- The world famous Los Angeles Athletic Club, founded in 1880 and home to the annual Wooden Awards Ceremony, witnessed yet another prestigious event last Sunday as it hosted the "Dave Yanai Tribute Dinner and Silent Auction," honoring the former men's basketball head coach of Cal State Dominguez Hills.


text:
Donors make veteran's Blairsville house a home
Purple Heart recipient Cory R. Howard exuded pride Friday as he talked about renovations to his century-old home in Blairsville.
"Come on in. Look at the kitchen — I never could have done this on my own," said Howard, 31, a retired Marine corporal who was seriously injured in 2007 in Iraq.
"Look — a granite counter top, oak cabinets that were custom-made to fit right here, a new sink and appliances and all of this space," Howard beamed.
As recently as 2 1⁄2 months ago, Howard and his wife, Risa, admit, they wouldn't have been so eager to show off their house at 175 W. First Ave.
The couple recalled using a bowl from a crock pot and running up and down a flight of stairs to empty water from the second-floor bathtub into the kitchen sink.
"The drain in the bathtub was so corroded it wouldn't drain," Howard said.
The antiquated bathroom plumbing often leaked onto the stove below, ruining meals before they were finished cooking.
Thanks to RenovatingHope, a West Chester-based nonprofit that provides home repairs, appliances and renovation services to the families of veterans and men and women serving in the military, the Howards and their 1-year-old daughter, Madison, celebrated completion of the project on Friday.
RenovatingHope founder Paul S. Hoffecker said the project is among more than 100 the 5-year-old organization has completed around the country.
"What we're trying to do is remove one stress from their daily lives and give them comfort and security in their own home. They don't have to worry about fixing a window, sink or the electrical outlets," he said.
"Most of these men and women are too proud to ask for help. But this is the least we can do for our heroes," said Hoffecker, who left his job as a hospital construction manager in New York to start the nonprofit.
The improvements to the Howard home include a completely updated kitchen and bathroom, an all-new electrical panel, new windows, a new rear door, repairs to walls and ceilings, painting and some landscaping. Hoffecker estimated the repairs at more than $50,000.
Pynos Construction and Joyce Plumbing were among local contractors that assisted with the renovations. Home Depot in Greensburg also assisted.
A California native, Howard is retired from the Marine Corps with a Silver Star and Purple Heart. He enlisted in 2003 and was involved in operation "Phantom Fury" in Fallujah. He was awarded a Meritorious Mast for his actions when three fellow Marines were seriously wounded.
In May 2007, an improvised explosive device went off under his 32-ton supply vehicle, resulting in second- and third-degree burns on 30 percent of his body. He suffered shrapnel wounds to his right side, and three bones in his right foot were shattered.
Because of his severe burns, he required skin grafts on his right arm and both legs, as well as facial surgery.
He suffers chronic pain and nerve damage in his extremities. A spinal problem that was a side effect of his treatment prevents him from working.
A military insurance program helped him purchase the wood-frame house in July 2012.
Howard was linked with Hoffecker's organization through staff at the Veterans Affairs office in Altoona. Howard thanked his mother, Mrs. Andrew Howard of San Clemente, with writing a letter alerting Veterans Affairs officials to the family's plight.
"I hate speaking in public," Howard said, adding that he made an exception during the community celebration honoring his service and completion of the project.
Howard agreed to participate, hoping it will bring awareness and more contributions to the RenovatingHope organization.
"I wanted to do this to help the men and women who follow me," Howard said.
Howard moved to Blairsville to study auto collision repair and refinishing at WyoTech. After graduating in September 2011, he was hired by BMW but could not stay on the job because of back pain.
Now, Risa studies welding at Westmoreland County Community College while he cares for their daughter as a stay-at-home dad.
"I absolutely love it," he said.
And he likes the home part, too.
"This has been a huge relief for us," Howard said, looking around the kitchen.
More information on the nonprofit is available at www.RenovatingHope.org
Paul Peirce is a staff writer for Trib Total Media. He can be reached at 724-850-2860 or firstname.lastname@example.com.
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While most comments will be posted if they are on-topic and not abusive, moderating decisions are subjective. We will make them as carefully and consistently as we can. Because of the volume of reader comments, we cannot review individual moderation decisions with readers.
We value thoughtful comments representing a range of views that make their point quickly and politely. We make an effort to protect discussions from repeated comments either by the same reader or different readers.
We follow the same standards for taste as the daily newspaper. A few things we won't tolerate: personal attacks, obscenity, vulgarity, profanity (including expletives and letters followed by dashes), commercial promotion, impersonations, incoherence, proselytizing and SHOUTING. Don't include URLs to Web sites.
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We welcome strong opinions and criticism of our work, but we don't want comments to become bogged down with discussions of our policies and we will moderate accordingly.
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Most-Read Westmoreland
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text:
November 27, 2015
CINCINNATI (AP) - Brandon Phillips drove in three runs with a bases-loaded double on Friday night, and Mike Leake got the better of left-hander Francisco Liriano for the third time this season, leading the Cincinnati Reds to a 5-3 victory over the Pittsburgh Pirates that tightened the NL Central.
The third-place Reds moved to within three games of second-place Pittsburgh. The Pirates lead their season series 6-5.
The Reds sent nine batters to the plate for four runs in the fifth off Liriano (9-4), who had his shortest outing of the season. Chris Heisey's infield single drove in the first run, and Phillips' double off Justin Wilson made it 5-0.
Heisey also had a solo homer off Liriano.
Leake (9-4) gave up solo homers to Starling Marte, Andrew McCutchen and Russell Martin in the sixth inning. Manny Parra fanned Pedro Alvarez with runners on second and third to end the seventh.
Aroldis Chapman struck out two in the ninth while getting his 22nd save in 25 chances.
Click Here to access the online Public Inspection File
Viewers with disabilities can get assistance accessing this station's FCC Public Inspection File by contacting the station with the information listed below. Questions or concerns relating to the accessibility of the FCC's online public file system should be directed to the FCC at 888-225-5322, 888-835-5322 (TTY), or email@example.com.


text:
ROV/AUV enhancements and upgrades
Precision control technologies for ROVs
and intervention AUVs
Project Manager: Steve Rock
Lead Scientist: Bruce Robison
Lead Engineer: Rob Mc Ewen
This new three-year effort will build upon and extend previous work in autonomous control for both ROVs and AUVs. Automatic stationkeeping, mosaicking, transect control, and jelly tracking have been demonstrated successfully on numerous Ventana dives. Proposed extended capabilities for both ROV and AUV applications include:
- Real-time benthic mosaicking capabilities to include relief information.
- Complete image registration in multiple benthic swath mosaics, enabling the creation of large field mosaics.
- Tracking of small midwater objects at close camera range (small jellies, bubbles, droplets, etc).
- Making improvements in existing system logic.
- Exploring new uses for midwater tracking tools (such as capture of midwater specimens and servicing instruments tied to vertical cables).
- Exploring the applicability of the new technologies to Dorado-class AUV operations


text:
HOME CBS Michigan State Spartans Gear Michigan State Spartans Ladies less than $10 (32 items) Product ID: 1291145
Main Content
Polish off your cute game day look with this Michigan State Spartans Glitter headband! Featuring Michigan State-themed graphics along with a glittery background, this headband is the perfect accessory you need to pull off that die-hard Michigan State fanatic look. It's the little details that make or break an outfit and this headband is just what you've been looking for!
- Acrylic covered printed glitter graphics
- Imported
- Made of plastic
- Not intended for children under 12
- Officially licensed collegiate product
- One size fits most
- Made in the USA
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text:
Studies of the apoptosis mechanisms involved in the pathogenesis of tuberculosis have suggested that Mycobacterium tuberculosis can actively interfere with the apoptosis of infected cells. In vivo studies have been performed in adult populations but have not focused on this process in children. In the present study, we analyzed spontaneous T lymphocyte (PBT) apoptosis in the peripheral blood of children with central nervous system tuberculosis (CNS TB), before and after chemotherapy, and compared the results with healthy controls.
A case-control study was conducted from January 2002 to June 2009. It included 18 children with CNS TB and 17 healthy controls. Spontaneous apoptosis of PBTs, including CD4+, CD8+ and CD8+/CD28+ T cells, was evaluated after 24 and 72 h of culture in complete medium, using the Annexin V detection test. Analysis was conducted before and after chemotherapy, and expression of the apoptotic markers CD95 (Fas) and Fas ligand (FasL) was evaluated.
Higher percentages of apoptotic T cells and CD4 lymphocytes were isolated from children with acute phase CNS TB than from children in the control group (p < 0.05). This difference significantly decreased after 60 days of specific treatment. In children with CNS TB, high levels of Fas ligand expression were detected in lymphocyte populations, associated with a high percentage of Fas positive cells, before and after treatment. In contrast to the CD4+ apoptosis profile, we did not find any significant difference in total CD8+ cell apoptosis between children with acute phase disease and the control group. However, the percentage of apoptotic CD8+/CD28+ T cells was significantly higher in the children with acute phase disease than in the healthy controls.
Our findings indicate that CNS TB in pediatric patients increases the sensitivity of CD4 and CD8+/CD28+ T cells to apoptosis, suggesting a hypoergic status of this infection. This could play a key role in the immunopathogenesis of this complicated form of TB. Interestingly, specific chemotherapy is able to normalize both apoptosis sensitivity and T-cell activation.
Pediatric tuberculosis (TB) remains one of the most important communicable diseases and represents a major health problem in the developing world. Globally, approximately 1 million new cases and approximately 500,000 deaths due to pediatric TB are reported every year [1,2].
In Italy, similar to many other industrialized nations, TB is a relatively rare disease. In the last few years, the incidence of TB has been less than 10 cases/100,000 population (in 2009 the rate was 7/100,000 population, corresponding to just over 4,200 cases) while according to WHO estimates, the prevalence of latent infections is 12% (corresponding to just over 7,200,000 latent infections) [1].
While 90% of immunocompetent adult patients infected by the tubercle bacillus will not develop the disease during their lifetime, children have shown various clinical forms of infection and progressive disease [2,3]. Although pulmonary TB tends to be the most common form of TB, TB of the central nervous system (CNS) carries the highest mortality and morbidity rates and develops in 4% of infected children, especially during infancy [4-6].
It is well known that the immune system of a child is too immature to stimulate a host protective response against intracellular pathogen growth. Some progress towards understanding the mechanism involved in immune responses to Mycobacterium tuberculosis infection has been made by studying adult patients. However, other aspects need to be assessed through research in pediatric populations. The relevant role of apoptosis (programmed cell death) in the development of the immune system in children has recently been highlighted in studies on the efficacy of the TB vaccine [7,8].
Recent studies have demonstrated that M. tuberculosis actively interferes with the apoptosis of infected cells in vitro as a means of virulence, and that dysregulation of the host's lipid metabolism is a major pathway for generating pathology and promoting necrosis over apoptosis [9,10]. However, the importance of apoptosis as a virulence mechanism in vivo and interaction of apoptotic mechanisms with the host cytokine response have been largely unexplored until recently, with this area of research slowly being understood [10-12].
A number of alternative mechanisms of peripheral T cell apoptosis have been defined. The distinction has been made between active apoptosis, which follows stimulation and activation of the T cells, and passive apoptosis, which occurs as a result of withdrawal of the sustaining cytokines following activation [13-16]. Activation of death receptors by their ligands can initiate apoptosis. Fas and Tumor Necrosis Factor (TNF) receptors are more clearly understood than others, and their important role in peripheral T cell apoptosis has been demonstrated. The Fas/Fas ligand (FasL) interaction is particularly important in initiating activation induced cell death of CD4+ T cells [17-20].
Understanding the specific mechanisms by which children's T cells fail to contain Mycobacterium TB infection could offer potential new targets for appropriate vaccines. In addition, studying the defects in infant immune responses that explain poor bacterial control may contribute more broadly to our understanding of severe forms of TB such as CNS TB.
In this study, we analyzed spontaneous T lymphocyte (PBT) apoptosis and the subsets CD3+, CD4+ and CD8+, including the analysis of apoptotic CD8+/CD28+ T cells, in the peripheral blood of children with CNS TB, before and after starting anti tubercular treatment and compared them with healthy control children.
Eighteen children with CNS TB (10 boys, 8 girls; mean age [± SD], 3.8 years [3.4]; range, 0.5-12 years] admitted to the G. Di Cristina Children's Hospital in Palermo, Italy, were selected according to Centers for Disease Control (CDC) Case Definition clinical and/or microbiological criteria between January 2002 and December 2009 [21].
Diagnosis was bacteriologically confirmed by polymerase chain reaction (PCR) and/or culture of M. tuberculosis complex in CSF samples and/or CSF culture, as previously reported [22,23]. CSF culture and PCR were positive in 60% and 90% of patients, respectively. Resistant strains to 1 or more anti-TB drugs were found in 4 children and their adult sources.
Seven patients (38%) had pulmonary TB. The source of infection was documented for 9 patients (50%): it was grandparents for 4 patients, parents for 3 patients, a teacher for 1 patient, and a neighbor for 1 patient.
All of the children received antitubercular treatment for 1 year, consisting of 2 months of isoniazid (INH), rifampicin (RMP), pyrazinamide (PZA) and streptomycin (SM) or ethambutol (ETB), followed by 10 months of RMP and INH [24].
All the subjects enrolled in the study were negative for human immunodeficiency virus (HIV).
A control group comprised 17 healthy children who were Purified Protein Derivative (PPD) skin test negative (10 boys and 7 girls; mean age [± SD], 5.6 years [3.2]; range, 2-12 years). The study protocol was approved by the Ethics Committee of the G. Di Cristina Hospital in Palermo (Italy) and informed consent was sought in accordance with the principles of the Declaration of Helsinki. Patients were thoroughly informed about the procedures and written informed consent was obtained from each of them. Peripheral blood was drawn from children with CNS TB during the acute phase of illness, and 30-60 days and 90 days after starting chemotherapy. The follow-up time point after the start of antitubercular therapy was chosen on the basis of previous studies conducted by our group [22,25,26].
Isolation of peripheral blood mononuclear cells (PBMCs)
PBMCs were isolated by Ficoll-Paque density centrifugation from 20 mL of heparinized blood drawn from children with CNS-TB and from the healthy children in the control group.
PBMC cultures: PBMCs were cultured in RPMI 1640 medium supplemented with 10% FCS at 37°C in a humidified atmosphere of 5% CO2 [27,28].
Apoptosis detection and PBT phenotype analysis
T cell spontaneous apoptosis was determined after 24 and 72 h of culture in complete medium, using the Annexin V detection kit as previously described [27,28]. Apoptotic cells were identified by means of double or triple staining with an Annexin V-FITC kit (Bender MedSystem, Vienna, Austria) and anti-human peridinin chlorophyll protein-CD3 (Becton Dickinson, San Jose, CA, USA), and anti-human phycoerythrin (RPE)-conjugated CD8 (Dakopatts, Glostrup, Denmark) or anti-human RPE-conjugated CD4 clone MT310 (Dakopatts). T lymphocytes were also investigated for their expression of CD28 (Dakopatts). Cell apoptosis and the phenotype of PBTs were determined with a FACSCalibur Plus flow cytometer (Becton Dickinson). Phycoerythrin-conjugated (X-928, Dakopatts) and FITC-conjugated mouse anti-human IgG1 (X-927, Dakopatts) were used as negative controls.
Fas and Fas-L expression
Fas and FasL expression were evaluated by flow cytometry (Becton Dickinson) using antihuman PE-conjugated CD95 and antihuman FITC conjugated CD95L (Dakopatts) MoAbs. PE-conjugated (X-928, Dakopatts) and FITC-conjugated mouse antihuman IgG1 (X-927, Dakopatts) were used as negative controls. Fas and FasL expressions are shown as the percentage of positive cells.
Statistical analysis
Discrete variables were analyzed using the chi-square and Fisher's exact tests, as needed. The independent Student's t test and the Mann-Whitney U statistic test were used for parametric and non-parametric analysis, respectively. The paired-samples Student's t-test and paired Wilcoxon signed-rank test were used for intragroup parametric and non-parametric analysis, respectively. All statistical tests were two-tailed and were applied at the 5% significance level. Data were analyzed with Epi Info software, version 3.2.2 (Centers for Disease Control and Prevention, Atlanta, Georgia, USA) and SPSS software (version 14.0; SPSS Inc., Chicago, IL, USA).
T lymphocytes, Fas and FasL during CNS TB
The mean (± SD) total lymphocyte and CD3+ lymphocyte counts in peripheral blood of patients in the acute phase of disease and in controls are shown in Table 1. There were no significant differences between the 2 groups (p > 0.05).
Table 1. Peripheral blood lymphocyte populations* in acute CNS TB children and uninfected children (controls)
Spontaneous apoptosis of PBTs isolated from CNS TB patients and from the healthy controls was evident after 24 h (p < 0.0005), and steadily increased after 72 h (p < 0.0005).
There was a significant increase in apoptotic CD3+ lymphocytes in the children with acute phase CNS TB after 24 (p < 0.0005) and 72 h of incubation compared with those in the control group (p < 0.0005). This increased sensitivity in CD3+ lymphocytes to apoptosis was still evident after 30-60 days of specific anti-tubercular therapy, but it was decreased in children treated for more than 90 days (Figure 1).
Figure 1. Apoptosis in T-lymphocytes from uninfected children (controls), and children with CNS tuberculosis before and after specific treatment, at the different time periods. Apoptosis was induced in vitro within 24 h (solid line) and after 72 h of culture in complete medium (dashed line).
Fas and FasL expression was significantly higher in the T lymphocytes of children with acute phase CNS TB than that in healthy control group children after 24 and 72 h of incubation (p < 0.0005, Figure 2a, b). This difference was still evident in patients treated for 30-60 days (Fas and FasL after 24 h, p = 0.010, p < 0.0005; Fas and FasL after 72 h, p < 0.0005, p < 0.0005), but it was decreased in children treated for more than 90 days (Fas and FasL after 24 h of incubation, p > 0.05, p = 0.024; Fas and FasL after 72 h of incubation, p = 0.003, p = 0.025; Figure 2a, b).
Figure 2. Fas (2a) and FasL (2b) expression during central nervous system tuberculosis in the illness group, before and after specific treatment at the different time periods, and in uninfected children (controls). Results are shown as percentage of Fas and FasL -expressing cells among T-lymphocytes after 24 h (solid line) or within 72 h of culture in complete medium (dashed line).
T Lymphocyte subset apoptosis during CNS TB
The mean (± SD) CD4+, CD8+ and CD8+/CD28+ T lymphocyte counts in patients during the acute phase of the disease and in the controls are shown in Table 1. There were no significant differences between the 2 groups (p > 0.05).
Spontaneous apoptosis was evaluated in different CD3+ lymphocyte subpopulations (CD4+, CD8+) of patients affected by CNS TB and in children in the control group. As shown in Figure 3, only CD4+ T-lymphocytes isolated from the TB children before treatment showed a greater sensitivity towards apoptosis than those of the control group (acute vs control after 24 and 72 h of incubation, p = 0.019 and p < 0.0005, respectively). This difference was decreased after 30-60 days of antitubercular treatment (after 24 and 72 h of incubation, p = 0.027 and p = 0.035, respectively) and disappeared after 90 days (acute vs control after 24 and 72 h of incubation, p > 0.05).
Figure 3. Apoptosis in CD4+ T cells from children with CNS tuberculosis, before and after specific treatment at the different time periods, and from uninfected children (controls). Results are shown as percentage of CD4+ T cells after 24 h (solid line) or within 72 h of culture in complete medium (dashed line).
Comparative analysis of apoptosis in CD8+ lymphocyte populations in acute phase CNS TB children treated for 30-60 days and for more than 90 days and in the controls showed no significant differences after 24 and 72 h of incubation (p > 0.05).
Analysis of apoptotic CD8+/CD28+ T cells showed impaired cell apoptosis in the acute phase of disease (acute vs control after 24 and 72 h of incubation, p < 0.0005 and p = 0.002, respectively). The difference between CNS TB patients and healthy control children decreased after 90 days of specific treatment (p > 0.05, Figure 4).
Figure 4. Percentage of CD8+/CD28+ T from children with CNS tuberculosis, before and after specific treatment at the different time periods, and from uninfected children (controls). Results are shown as percentage of CD8+/CD28+ T cells after 24 h (solid line) or within 72 h of culture in complete medium (dashed line).
The results of our study show that PBTs isolated from children with CNS TB had a stronger apoptotic response and underwent apoptosis more rapidly than those of healthy subjects, even after 3 months of antitubercular treatment. These responses were due to high levels of FaL expression in lymphocyte populations. Moreover, the number of Fas positive cells remained high even after starting treatment for TB. The reason for these findings may be because Koch's bacillus produces or induces substances in macrophages that increase the sensitivity of lymphocytes to apoptosis by increasing Fas expression or Fas-L for protection against antitubercular activity [9,29].
We did not find any significant difference in the absolute number of T lymphocytes and their subsets in the peripheral blood in children with CNS TB and healthy controls. A previous study of adult pulmonary TB patients showed a significantly lower percentage of CD3+ and CD4+ cells, and a significantly lower ratio of CD4+ and CD8+ cells compared with healthy controls [30].
CD4+ cells are critical in immunity against M. tuberculosis infection. CD4+ T lymphocytes play 2 important roles in TB infection: first, they produce cytokines that govern cell-mediated immune responses; and second, they eliminate infected macrophages via apoptosis [31-33].
The relevant role of CD4+ cells in the pathogenesis of CNS TB is confirmed by CD4+ cell counts and TB meningitis in the HIV population [33]. We observed a high percentage of CD4+ T lymphocyte apoptosis in our study population, both in the acute phase of disease and after the start of specific treatment. Therefore, CD4 depletion by apoptosis is a foreseeable phenomenon in TB patients. In fact, we found that patients with a more severe form of TB had CD4+ lymphocyte depletion despite their CD4+ cell counts. In contrast to the CD4+ apoptosis profile, we did not find any significant difference in CD8+ cell apoptosis between children with CNS TB and the control group. This could be the consequence of increased CD4+ lymphocyte apoptosis through the Fas/FasL system.
CD8+ T cells can efficiently eradicate TB infection by inducing apoptosis of infected cells, and this cell death is mainly, but not always, mediated via the Tumor Necrosis Factor Receptors (TNFR) [17,34,35]. The hypoergic status of CD8 T cells and the increased susceptibility of CD4 T cells to apoptosis may be induced by specific cytokines produced during infection to avoid an immunological response against Koch's bacillus [14,35]. Although different M. tuberculosis specific CD8+T cell subsets, such as CD27+ and CD28+ (activated T cells), may be involved in these mechanisms, their role is not well understood in pediatric patients [31,36].
Interestingly, CD8+/CD28+ T cell apoptosis was significantly lower in the children with CNS TB before chemotherapy, suggesting a protective role of these cells in response to M. tuberculosis infection. Contrasting results have been reported in other studies. Both increases and decreases in levels of CD8+/CD28+ T cells in peripheral blood have been detected in adult patients with active TB compared with healthy controls [36,37]. However, further studies are required to elucidate the mechanisms of these phenomena.
Our study suggests that TB infection in children increases the sensitivity of CD4+ T lymphocytes to apoptosis and causes a decrease in CD8+ activated T lymphocytes. Interestingly, chemotherapy was able to normalize both apoptosis sensitivity and T cell activation. This could play a key role in the immune pathogenesis of the disease. Involvement of the CNS is a serious complication of TB and is most frequent in children aged between 6 months and 6 years, although it can occur at any age [4,5]. Ten of the children in our study population were in this age range. Consequently, our data may help the understanding of what type of immune response against the tubercle bacillus is activated in the first year of life.
To our knowledge, this is the only study to date to evaluate apoptosis in T lymphocytes from children with CNS TB. A better understanding of apoptosis regulation in TB is required to develop new immune-based therapies aimed at modulating apoptosis in infected patients. Considering the current, very poor laboratory support for the diagnosis and management of childhood TB, further studies with large numbers of subjects are required to define the clinical value of these assays.
List of abbreviations
FACS: Fluorescence Activated Cell Sorting; CD: Cluster differentiation; FITC: fluorescein- isothiocyanate; PE: phycoerythrin.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
PD designed the study and drafted the manuscript. NC, FD, BP, DS and MG set up and conducted the study in the field and contributed to the interpretations of results. MM and MT were responsible for laboratory analysis. AC was responsible for the acquisition, statistical analysis and interpretation of data. The ethics application and funding applications were submitted by PD, AR and LT as the principal pediatric investigators. MC provided microbiological data. MT supported apoptosis laboratory results, supervised the study and revised the manuscript. All authors have read and approved the final manuscript.
WHO: Global tuberculosis control 2010.
UNICEF: The state of the World's children.
Newton SM, Brent AJ, Anderson S, Whittaker E, Kampmann B: Paediatric tuberculosis.
Lancet Infect Dis 2008, 8:498-510. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Swaminathan S, Rekha B: Pediatric tuberculosis: global overview and challenges.
Clin Infect Dis 2010, 50:184-194. PubMed Abstract | Publisher Full Text
Garg RK: Tuberculosis of the central nervous system.
Postgrad Med J 1999, 75:133-140. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Be NA, Kim KS, Bishai WR, Jain SK: Pathogenesis of central nervous system tuberculosis.
Curr Mol Med 2009, 9:94-99. PubMed Abstract | Publisher Full Text
Hanekom WA: The immune response to BCG vaccination of newborns.
Ann N Y Acad Sci 2005, 1062:69-78. PubMed Abstract | Publisher Full Text
Soares AP, Scriba TJ, Joseph S, Harbacheuski R, Murray RA, Gelderbloem SJ, Hawkridge A, Hussey GD, Maecker H, Kaplan G, Hanekom WA: Bacillus Calmette-Guérin vaccination of human newborns induces T cells with complex cytokine and phenotypic profiles.
Mustafa T, Bjune TG, Jonsson R, Pando RH, Nilsen R: Increased expression of fas ligand in human tuberculosis and leprosy lesions: a potential novel mechanism of immune evasion in mycobacterial infection.
Scand J Immunol 2001, 54:630-639. PubMed Abstract | Publisher Full Text
Briken V, Miller JL: Living on the edge: inhibition of host cell apoptosis by Mycobacterium tuberculosis.
Future Microbiol 2008, 3:415-422. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Abebe M, Kim L, Rook G, Aseffa A, Wassie L, Zewdie M, Zumla A, Engers H, Andersen P, Doherty TM: Modulation of cell death by M. tuberculosis as a strategy for pathogen survival.
Clin Dev Immunol 2011, 2011:678570.
Epub 2011 Jan 4PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Behar SM, Divangahi M, Remold HG: Evasion of innate immunity by mycobacterium tuberculosis: is death an exit strategy?
Nat Rev Microbiol 2010, 8:668-674. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Boom WH, Wallis RS, Chervenak KA: Human Mycobacterium tuberculosis-reactiveCD4+ T-cell clones: heterogeneity in antigen recognition, cytokine production, and cytotoxicity for mononuclear phagocytes.
Infect Immun 1991, 59:2737-2743. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Dubaniewicz A, Trzonkowski P, Dubaniewicz-Wybieralska M, Dubaniewicz A, Singh M, Myśliwski A: Mycobacterial heat shock protein-induced blood T lymphocytes subsets and cytokine pattern: comparison of sarcoidosis with tuberculosis and healthy controls.
Respirology 2007, 12:346-354. PubMed Abstract | Publisher Full Text
Arcila ML, Sánchez MD, Ortiz B, Barrera LF, García GAS, Rojas M: Activation of apoptosis, but not necrosis, during Mycobacterium tuberculosis infection correlated with decreased bacterial growth: role of TNF-alpha, IL-10, caspases and phospholipase A2.
Cell Immunol 2007, 249:80-93. PubMed Abstract | Publisher Full Text
Cowley SC, Elkins KL: CD4+ T cells mediate IFN-gamma-independent control of Mycobacterium tuberculosis infection both in vitro and in vivo.
J Immunol 2003, 171:4689-4699. PubMed Abstract | Publisher Full Text
Sytwu HK, Liblau RS, McDevitt HO: The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice.
Immunity 1996, 5:17-30. PubMed Abstract | Publisher Full Text
Wong B, Choi Y: Pathways leading to cell death in T cells.
Curr Opin Immunol 1997, 9:358-364. PubMed Abstract | Publisher Full Text
Mrugacz M: Fas expression in conjunctival epithelial cells of patients with cystic fibrosis.
J Interferon Cytokine Res 2009, 29:735-740. PubMed Abstract | Publisher Full Text
Zhong J, Gilbertson B, Cheers C: Apoptosis of CD4+ and CD8+ T cells during experimental infection with Mycobacterium avium is controlled by Fas/FasL and Bcl-2-sensitive pathways, respectively.
Immunol Cell Biol 2003, 81:480-486. PubMed Abstract | Publisher Full Text
CDC: Case definitions for infectious conditions under public health surveillance.
Nastasi A, Mammina C: Epidemiological study of tuberculosis in Palermo, Italy: IS6110 fingerprinting of Mycobacterium tuberculosis strains isolated in the years 1994-1998.
Infection 1999, 27:318-222. PubMed Abstract | Publisher Full Text
Saporito L, Florena AM, Colomba C, Pampinella D, Di Carlo P: Prurigo nodularis due to Mycobacterium tuberculosis.
J Med Microbiol 2009, 58:1649-1651. PubMed Abstract | Publisher Full Text
American Thoracic Society: Treatment of tuberculosis and tuberculosis infection in adults and children.
Am J Respir Crit Care Med 1994, 149:1359-1374. PubMed Abstract | Publisher Full Text
Di Carlo P, Romano A, Melis M, Abbagnato L, Caccamo N, Meraviglia S, Dieli F: An overview of the role of T cells in controlling tuberculosis infection in a pediatric population.
Melis MR, Pace E, Di Carlo P, Romano A, Titone L, Vignola AM, Ferraro M, Tipa A, Bonsignore G, Gjomarkai M: Increased peripheral T-Lymphocyte apoptosis in Childhood tuberculosis.
Am J Respir Crit Care Med 2002, 165:289.
International Conference, Atlanta, Georgia. American Thoracic Society
Pace E, Gjomarkaj M, Melis M, Profita M, Spatafora M, Vignola AM, Bonsignore G, Mody CH: Interleukin-8 induces lymphocyte chemotaxis into the pleural space. Role of pleural macrophages.
Am J Respir Crit Care Med 1999, 159:1592-1599. PubMed Abstract | Publisher Full Text
Tolomeo M, Di Carlo P, Abbadessa V, Titone L, Miceli S, Barbusca E, Cannizzo G, Mancuso S, Arista S, Scarlata F: Monocyte and Lymphocyte apoptosis resistance in acute and chronic brucellosis and its possible implications in Clinical Management.
Clin Infect Dis 2003, 36:1533-1538. PubMed Abstract | Publisher Full Text
Gallegos AM, van Heijst JW, Samstein M, Su X, Pamer EG, Glickman MS: A gamma interferon independent mechanism of CD4 T cell mediated control of M. tuberculosis infection in vivo.
PLoS Pathog 2011, 7:e1002052. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Wu YE, Zhang SW, Peng WG, Li KS, Li K, Jiang JK, Lin JH: Changes in lymphocyte subsets in the peripheral blood of patients with active pulmonary tuberculosis.
J Int Med Res 2009, 37:1742-1749. PubMed Abstract | Publisher Full Text
Kapina MA, Shepelkova GS, Mischenko VV, Sayles P, Bogacheva P, Winslow G, Apt AS, Lyadova IV: CD27low CD4 T lymphocytes that accumulate in the mouse lungs during mycobacterial infection differentiate from CD27high precursors in situ, produce IFN-gamma, and protect the host against tuberculosis infection.
J Immunol 2007, 178:976-985. PubMed Abstract | Publisher Full Text
Winslow GM, Cooper A, Reiley W, Chatterjee M, Woodland DL: Early T-cell responses in tuberculosis immunity.
Immunol Rev 2008, 225:284-299. PubMed Abstract | Publisher Full Text
Vidal JE, de Oliveira AC, Hernández AV: CD4+ T-cell count and cerebrospinal fluid findings in HIV-infected patients with tuberculous meningitis.
Int J Tuberc Lung Dis 2010, 14:1496-1497. PubMed Abstract | Publisher Full Text
Alexander-Miller MA, Leggatt GR, Sarin A, Berzofsky JA: Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL.
J Exp Med 1996, 184:485-492. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Thoma-Uszynski S, Stenger S, Modlin R: CTL-Mediated Killing of Intracellular Mycobacterium tuberculosis Is Independent of Target Cell Nuclear Apoptosis.
J Immunol 2000, 165:5773-5779. PubMed Abstract | Publisher Full Text
Yu T, Yang YH, Dong DQ: The role of CD8+CD28-regulatory T lymphocytes in pulmonary tuberculosis.
Zhonghua Jie He He Hu Xi Za Zhi 2007, 30:130-132. PubMed Abstract
Yang Y, Tang SJ, Zhang Q, Sun H, Liu YD, Hao XH, Yao L, Gu J: The changes and the significance of cellular immune function in peripheral blood of patients with multidrug-resistant and extensively drug-resistant pulmonary tuberculosis.
Zhonghua Jie He He Hu Xi Za Zhi 2011, 34:109-113. PubMed Abstract
Pre-publication history
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November 27, 2015
Iranian women stand in line to cast their votes in the presidential election, at the Masoumeh shrine in Qum, about 120 kms south of Tehran, Friday, June 12, 2009. The election follows a hotly contested campaign pitting current president Mahmoud Ahmadinejad against leading challenger and reformist candidate Mir Hossein Mousavi, amongst others. (AP Photo/Kamran Jebreili)
CAIRO (AP) - Iran's president is quoted by an Arabic satellite channel as saying he offers friendship to the U.S.
However, Mahmoud Ahmadinejad also taunted Washington by saying
he does not fear an attack by the U.S. because it could not even defeat a small army in Iraq, according to Al Jazeera television.
The station aired an interview with Ahmadinejad Sunday in Arabic translation from the original Farsi.
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"It appears a rare type of tsunami - called a 'metoetsunami' - hit the Jersey coast June 13," we reported last week. Although undersized as tsunamis go, the 6-foot wave knocked three people off Barnegat Light's inland jetty.
A "meteotsumani"? Really?
This has me wondering: Is our weather's unpredictability finally growing into long-established terms like "derecho," "katafront" and "meteotsunami," or is the weather cabal creating new names simply to boost ratings even though - perhaps because - they terrorize audiences?
I'm going with No. 2. As horror maestros Wes Craven, John Carpenter and Stephen King learned early on, the only thing scarier than a creepy villain, is a creepy villain with a name. Jason and Pennywise, Chucky and Freddy still lurk in our subconscious minds, ready to appear in a sewer grate and grab our ankles when we least expect it.
Why else would the Weather Channel have not only begun naming snowstorms, but giving them steroidal names like Brutus, Draco, Gandolf, Magnus, Rocky, Triton and Zeus?
Their explanation is all wet: "Attaching a name," coos Weather.com, "makes it much easier to follow a weather system's progress." No offense, guys ... but so does "It's going to snow this weekend."
The full conspiracy is revealed, though, with this physics-defying claim: "A storm with a name takes on a personality all its own, which adds to awareness."
Nonetheless, it's working. Used to be, only chemical plant explosions and gunmen in bell towers garnered the kind of team coverage now given to flurries and breezes, mists and hoarfrost.
I no longer leave the house without packing an umbrella, pulling on hiking boots, grabbing a flashlight and protein bars, charging the mobile phone, dropping the cat at the kennel, boarding the windows and carrying the TV upstairs. And I won't leave town without topping off the tank.
Once home, I huddle on my couch, surrounded by candles, beef jerky and crank radios. The Weather Channel glows in the background - because anything can happen. Heat waves in April. Snow in October. Back-to-back 100-year storms. Thunderstorms here, locusts there, and don't forget the afternoon tornado watch.
One day it hit me: Why stop with snowstorms? If names raise awareness, then we could sure use these:
Gradient Wind: The sound of the expulsion of hot air by the New Jersey Legislature when attempting to legislate.
Gustnado: A temporary dust whirl or debris cloud of insults, delivered by Gov. Chris Christie when presented with a question he'd rather not answer.
Absolute Zero: Describes the combined contributions of Rutgers President Robert Barchi to the transparent and ethical functioning of the university athletics department.
Cumulus congestus: The outcome of any collective action attempted by members ofCongress.
Stratopause: A condition describing political parties as they wait for the "right time" - but under no circumstances before 2023 - to compromise.
Negative Vorticity Advection: The sucking sound made by the Republican right when Gov. Christie befriends President Obama - like when he won the prez a plush bear in a Point Pleasant Beach arcade.
Landspout: Describes the resistance of shorefront homeowners to dunes that will protect their houses but diminish their views.
Isobar: The term for a New Jersey drinking establishment that pours watered-down booze - even river water - over perfectly good ice.
Mandolin Wind: Describes the rare condition when, no matter which radio button you push, they're playing a Rod Stewart song.


text: Cool Retro Monorail of Scotland by Lala Balakala · August 4, 2012 In Scotland of 1930s there was an inventor who got funding for his project of monorail road. It was very luxurious and comfortable for the passengers. The propeller installed on front of the carriage let it to achieve the speed of 100 miles per hour! share:0010 Continue: 1 2 3 4 5 6 7 next »


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By Stuart Hodes
Copyright 2004 Stuart Hodes
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NEW YORK -- To encounter
dance in a venerable tradition that is true to that tradition and
also entirely new is a rare and exciting experience. In the somber
celebrations of Elena Lentini Dance Theater at the Washington Square
Methodist Church on Saturday, April 24, I saw Middle Eastern dance
In "Standing in Cave,"
six dancers, fabric-swathed from the tops of their high stovepipe
hats to the floor, hover as if suspended in space to the mournful
sounds of wind instruments that seem to be blown by dying breaths.
No faces are seen, evoking, perhaps, the anonymity and loneliness
of purdah.
Veiled throughout her
solo, "On Being," Lentini whirls and swirls the fabric without ever
exposing her face. In "Valor," Serpil Civan wears a metallic head
dress that covers her eyes and nose, while each hand bears a similar
headdress, to evoke the awesome presence of a three-headed divinity.
In "Elementals," four dancers wearing silver-bangled black project
defiant nonchalance as they execute moves suggestive of those that
are still termed "belly dancing." Another solo powerfully evokes
a woman's longing, which, to me, could be longing for escape from
the seraglio. The riotous music, sumptuous costumes, commanding
authority, and starkly individual sensibility of Elena Lentini reveals
new depths in this ancient form, and a whole new world of possibilities.
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The Vermilion Cliffs Highways is a project involving a partnership of 40 public and private entities providing a combination of 21 interpretive sites or scenic overlooks along 277 miles of state highways in northern Arizona and southern Utah. These roads generally follow the winding ramparts of the lengthy and beautiful Vermilion Cliffs. This cliff line is traceable from the Gunlock Reservoir area of southwest Utah to the Tuba City area of north-central Arizona.
Scenic overlooks and historic and prehistoric sites along the highways convey various aspects of the overall theme of "exploration and survival". These sites are tied inextricably to past and present "exploration" of existing landforms and the use of natural resources for "survival".
The Vermilion Cliffs Highways traverse some of the most scenic landforms in the West. In addition, the various highways are, in many cases, historic transportation routes used for centuries by succeeding waves of humanity in the region.
Distance: 277 Miles
Directions: From St George, Utah, Travel south to the Virgin River Gorge and the highways begin here.
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Dear Carolyn: I'm about to have a baby and wondered if you had thoughts on some things my husband and I should discuss before the baby comes. We want to be on the same page about parenting stuff before the chaos kicks in. Right now we are both clueless about what to discuss, neither of us having any baby/parenting experience. - Impending Parenthood
Dear Impending: Oh my goodness, you've ordered a pot roast at a tapas bar. But, er, OK:
Talk about the fact that you are both, simultaneously and almost unrelentingly, going to be too stressed or just plain tired for whatever it is you need to do at the moment ...


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Jonathan Demme's Neil Young Film Comes to Theaters, DVD
By Tom Breihan on February 26, 2010 at 9:00 a.m. EST
The Silence of the Lambs/Rachel Getting Married director Jonathan Demme is an old hand at filming Neil Young, filming live shows, and filming Neil Young live shows. Demme previously directed Young's 2006 concert film Heart of Gold, as well as the non-Neil concert docs Stop Making Sense (Talking Heads) and Storefront Hitchcock (Robyn Hitchcock). He also got TV on the Radio's Tunde Adebimpe to sing Young's "Unknown Legend" in Rachel Getting Married. The man knows what he's doing, so the news that he's directed another Neil Young concert film is welcome indeed.
News in Brief: Scion Rock Fest, Dead Meadow, Emma Pollock, Jaguar Love
By Tom Breihan on February 8, 2010 at 4:20 p.m. EST
-- On March 13, a pretty seriously badass group of metal bands will descend upon Columbus, Ohio for the second annual Scion Rock Fest. Cannibal Corpse, Shrinebuilder, Voivod, Brutal Truth, YOB, Absu, D.R.I., Pelican, Hate Eternal, Trap Them, Saviours, Liturgy, and others will play, and tickets are free if you RSVP here.
-- On March 23, California-based stoner-rockers Dead Meadow will release a DVD called Three Kings, a sort of hybrid concert doc and fantasy film, via Xemu. It'll come packaged with a CD or LP featuring new songs and live recordings.
-- Chemikal Underground will release The Law of Large Numbers, the new album from former Delgados member Emma Pollock, on March 2. Pollock's husband and fellow former Delgado Paul Savage produces.
-- Also on March 2, Fat Possum will release Hologram Jams, the second album from the ex-Blood Brothers band Jaguar Love and the band's first since shedding a member and becoming a duo.
Mogwai Reveal Live CD/DVD Details
By Tom Breihan on January 21, 2010 at 4:45 p.m. EST
Back in November, we reported that La Blogotheque filmmakers Vincent Moon and NathanaĂŤl Le Scouarnec had documented Mogwai's gut-blastingly loud live show for a forthcoming concert film called Burning. Well, Burning will soon come out on DVD, and it'll come with a CD, entitled Special Moves, that will serve as the band's first ever live album. As the band's website announces, the CD/DVD set will be out this spring on Mogwai's own Rock Action label.
Blur Documentary Coming to DVD
By Tom Breihan on January 15, 2010 at 5:20 p.m. EST
Back in November, we reported that a Blur documentary called No Distance Left to Run was set to debut in the UK this month. Well, NME reports that the film, from directors Dylan Southern and Will Lovelace, will indeed begin a UK theatrical run next week. It premiered last night at London's Leicester Square, with all four band members on hand for the screening. The movie will also be available as a double-disc DVD set on February 15 via Parlophone.
Disc one will include the film itself, directed by Dylan Southern and Will Lovelace, which documents the band's big reunion last year. In addition to footage from the reunion shows, it includes home videos, backstage footage, and interviews. We've got the goosebump-inducing trailer below. (Also, the Guardian has a clip of the band playing "Parklife" at the Rough Trade East record store.)
Disc two is a concert film taped at two of Blur's shows at London's Hyde Park. We've got the tracklist and trailer for disc two below as well:
Sonic Youth Working on Soundtrack, Live DVD, New Album
By Ryan Dombal on December 10, 2009 at 4:30 p.m. EST
Photo by Michael Schmelling
Sonic Youth stay busy. They always have, and if their future plans are to be believed, they always will.
In an interview with the BBC, guitarist Lee Ranaldo revealed info about the band's upcoming projects, which include a follow-up to this year's The Eternal, a soundtrack for an unnamed "French teen film", as well as a DVD chronicle of their recent Daydream Nation tour, during which they played the 1988 classic in its entirety. Vacations are overrated.
CSS Tour With Tilly and the Wall Spawns Concert Documentary
By Tom Breihan on December 10, 2009 at 1:30 p.m. EST
Last year, Brazilian art-pop party-starters CSS hit the road with Omaha indie poppers Tilly and the Wall. Omaha filmmaker Rob Walters documented the proceedings.
Next month, we'll see the result in the form of the concert DVD CSS & Tilly and the Wall Appearing Live Tonight! The 73-minute DVD will come out January 12 on White Light Media, and it'll feature tons of performances from both bands, as well as behind-the-scenes footage. Below, we've got a complete list of the songs you'll hear from both bands.
Beastie Boys' Adam Yauch Launches DVD Subscription Series
By Tom Breihan on December 2, 2009 at 4:40 p.m. EST
Oscilloscope Laboratories, the film production house and distributor started by Beastie Boy and cancer survivor Adam Yauch, already has a few strong movies under its belt, like Kelly Reichardt's unflinching tearjerker Wendy and Lucy and Yauch's own deeply engaging high school basketball doc Gunnin' for That #1 Spot.
If you buy into Oscilloscope's new Circle of Trust subscription series, you'll get the next 10 DVDs that the company releases for a grand total of $150. The movies will arrive about a week before their release date, and subscribers will also be able to buy DVDs from the company's catalog for half price.
In a press release, Yauch says, "There's a real void in the marketplace since Columbia Record club is no longer active, so we're hoping to hire a staff of tens of thousands to call our valuable membership over and over again and harass them until they cry."
Michael Jackson Film Coming to DVD
By Tom Breihan on December 1, 2009 at 3:35 p.m. EST
This Is It, director Kenny Ortega's documentary/concert film about Michael Jackson's rehearsals for his ill-fated run of London shows, pulled in $240 million in worldwide theatrical release during the past month, and it scored a ton of surprisingly positive reviews (this one being my favorite). And the movie will be on shelves early enough that you'll actually be able to use your holiday season gift cards to cop it.
MTV reports that Sony Pictures will drop This Is It on DVD and Blu-Ray on January 26. According to Home Media, the DVD will include 60 minutes of bonus footage, and the Blu-Ray will include 90.
News in Brief: Deer Tick, MC Paul Barman, Wesley Willis, By Divine Right
By Tom Breihan on November 23, 2009 at 5:20 p.m. EST
Photo by Kendall Pavan
-- On December 1, the Brian Williams-beloved roots-rockers Deer Tick will release their More Fuel for the Fire EP via Partisan. An iTunes exclusive, the EP will include three new songs and one live track.
-- Hey, remember exceedingly goofy early-00s joke-rapper MC Paul Barman? He's still around! And tomorrow, November 24, he'll release a new album called Thought Balloon Mushroom Cloud, available exclusively from his website, the A.V. Club reports. The album features appearances from DOOM and Del the Funky Homosapien, production from ?uestlove and Prince Paul, and two tracks with director Michel Gondry.
-- On December 8, Eyeosaur/MVD Visual will release Wesley Willis's Joy Rides, a DVD documentary about the beloved schizophrenic outsider artist who died in 2003. Watch a trailer here.
-- Once upon a time, Leslie Feist, Broken Social Scene's Brendan Canning, and Holy Fuck's Brian Borcherdt were part of the Canadian indie band By Divine Right. They've moved on to other things, but By Divine Right soldiers on. And on December 8, they'll release Mutant Message, their first album in five years, via Hand-Drawn Dracula.
Aziz Ansari Preps Stand-Up Album
By Tom Breihan on November 12, 2009 at 2:10 p.m. EST
He's friends with Kanye and James Murphy, he's killing it as Tom Haverford on "Parks and Recreation", and his ridiculous Raaaaaaaandy character was maybe the best thing about the movie Funny People. Comedian Aziz Ansari is in a rare zone right now, so it's about damn time he finally got together his first stand-up album.
On January 17, Comedy Central will air Ansari's stand-up special Intimate Moments for a Sensual Evening. Two days later, the network will release the special on CD/LP and DVD. That's the (amazing) cover above.
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text:
Mikhail Fomenko has been named as Ukraine's new national team coach and is charged with reviving the team's FIFA World Cup™ qualifying campaign. The announcement was made after a meeting of the national football federation FFU, Interfax news agency reported.
The FFU members unanimously voted for the 64-year-old, who has previously coached Ukrainian sides Dynamo Kiev, CSKA Kiev as well as the Guinea national side.
The former England and Manchester City manager Sven-Goran Eriksson was the only other candidate for the post.
Fomenko, who enjoyed a successful playing career in which he won the 1975 UEFA European Cup Winners' Cup and UEFA Super Cup with Dynamo Kiev, signed a one-year contract, which can be extended for another two years if Ukraine qualify for Brazil in 2014.
Fomenko told ffu.org.ua: "I want to thank the board and president of the FFU for their trust. I understand the responsibility entrusted in me and challenges that face the national team of Ukraine.
"Our primary objective is to get to the finals of the World Cup in Brazil, and for this we need to take at least second place in our qualifying group."
He succeeds Ukrainian footballing icon Oleg Blokhin, who announced he was leaving the post to take over Dynamo Kiev in September.
Fomenko made 212 appearances in eight years with Dynamo during the 1970s and also won 24 international caps for the former Soviet Union.
Ukraine are presently fifth in their qualifying group with just two points from three matches, eight points behind the group leaders Montenegro, although the Ukrainians have a game in hand on them.


text:
Mastering Speech
Less Than One: Selected Essays by Joseph Brodsky
Less Than One: Selected Essays by Joseph Brodsky
The Garden of Eden by Ernest Hemingway
Dateline: Toronto/The Complete Toronto Star Dispatches, 1920–1924 by Ernest Hemingway, edited by William White
Hemingway: A Biography by Jeffrey Meyers
Along With Youth: Hemingway, The Early Years by Peter Griffin
The Young Hemingway by Michael Reynolds
Ernest Hemingway and His World by Anthony Burgess
The Selling of the Royal Family: The Mystique of the British Monarchy by John Pearson
The Soviet Paradox: External Expansion, Internal Decline by Seweryn Bialer
Gorbachev by Zhores A. Medvedev
Freud's Discovery of Psychoanalysis: The Politics of Hysteria by William J. McGrath
Freud and His Father by Marianne Krull
Mies van der Rohe: A Critical Biography Modern Art by Franz Schulze. in association with the Mies van der Rohe Archive of the Museum of
Mies van der Rohe by David Spaeth, preface by Kenneth Frampton
Mies van der Rohe: The Villas and Country Houses by Wolf Tegethoff
Mies van der Rohe: Architect as Educator (distributed by University of Chicago Press) Catalog for Exhibition at S. R. Crown Hall, June 6–July 12, 1986.
Mies van der Rohe Centennial Exhibition Museum of Modern Art, New York February 10–April 15, 1986. Museum of Contemporary Art, Chicago May 9–August 10, 1986
Mies van der Rohe: Drawings Max Protetch Gallery, New York February 5–March 1, 1986
Mies A film produced and directed by Michael Blackwood
The African Witch by Joyce Cary
Mr. Johnson by Joyce Cary
Herself Surprised by Joyce Cary
To Be a Pilgrim by Joyce Cary
The Horse's Mouth by Joyce Cary
Prisoner of Grace by Joyce Cary
Except the Lord by Joyce Cary
Not Honour More by Joyce Cary
The Good Apprentice by Iris Murdoch
John Bayley is a critic and novelist. His books include Elegy for Iris and The Power of Delight: A Lifetime in Literature.
David Cannadine is the Dodge Professor of History at Princeton.
James Fallows is National Correspondent for The Atlantic.His books include Free Flight: Inventing the Future of Travel, Blind into Baghdad: America's War in Iraq, and China Airborne.
Martin Filler's latest book, Makers of Modern Architecture, Volume II, has been long-listed for the 2014 PEN/Diamonstein-Spielvogel Award for the Art of the Essay. Filler was born in 1948 and received degrees in art history from Columbia University. He has been a contributor to The New York Review of Books since 1985 and his writing on modern architecture has been published in more than thirty journals, magazines, and newspapers in the US, Europe, and Japan. His first collection of New York Review essays, Makers of Modern Architecture, was published in 2007. Filler is a fellow of the American Academy of Arts and Sciences. He and his wife, the architectural historian Rosemarie Haag Bletter, live in New York and Southampton.
Klara Glowczewska, Executive Editor at Condé Nast Traveler, has translated several other books by Kapus´cin´ski. (April 2001)
Michael Ignatieff is the Edward R. Murrow Professor of Practice at the Harvard Kennedy School and the author of Fire and Ashes: Success and Failure in Politics. (December 2015)
Ryszard Kapuscinski lives in Warsaw. The essay in this issue appears in The Shadow of the Sun, which is being published this month by Knopf. (April 2001)
Brad Leithauser is a novelist, poet, and essayist. He lives in Massachusetts.
Wilfrid Sheed (1915–2011) was a British-American novelist and critic.
Edward R. F. Sheehan is a former US diplomat in the Middle East, a novelist (Cardinal Galsworthy), and the author of The Arabs, the Israelis, and Kissinger. He is a former Fellow of Harvard's Weatherhead Center for International Affairs. (April 2004)


text:
On October 1st, 2014, we published revised versions of our Terms and Conditions. Your continued use of GrabOne means you agree to this revised document, so please take a few minutes to read and understand it. Ok, got it
We're not saying you have to go off revolutionising the eating habits of eight-year-olds across Ireland, but y'know, if you wanted to you can do so with colour and style with these great knives from Mr. Oliver's funky range of kitchenwear.
€18 for Jamie Oliver funky three-piece knife set, including delivery within the Republic of Ireland (value €30).
The set includes:
E: firstname.lastname@example.com


text:
[Edited by DarthWright, 12/9/2007 9:07:47 PM]
no its not, it needs mee to be a winning page
edit- aww next page >_<
The VGAs lie....they gave bioshock game of the year....And not halo 3. Bioshock was great and all but....well it just wasnt as good as halo 3.
[/total Halo fanboi]
Bioshock won for what it had...not for what it did have. I'm sure that the Bioshock campaign was better than Halo 3...because that's why it won.
[Edited by darkish_raven, 12/9/2007 9:30:23 PM]
Better than Bioshock's by far.
Assassin's CreedSuper Mario GalaxyMass EffectHalo 3 (honestly, this wasn't near GotY for me =\ great game, but not GotY material <_<)CoD 4 (never played it, but it sounds good)
*waits for you guys to kill me... or die trying*
i dont wanna start this again lm...
I had no idea what candidates were on the VGAs, so here's mine :
I think seeing on how VGA stands for Video Game Awards...I would think it would be the popular games of 2007.
Halo 3 did win best Multiplayer AND Most addictive game fueled by Dew...so yeah...at least it won best MP...I'm happy.


text:
Edinburgh toasts latest wave of British filmmaking
Critical enthusiasm for a new wave of British filmmaking was reflected in the prizes announced Sunday night at the 54th Edinburgh International Film Festival.
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text:
As the tears ran down Aimee's face she tried not to burst out and just sob. "I feel like a failure! What is wrong with me?" cried Aimee.
She could not figure out what had started this emotional cry. Aimee was on her lunch break at work and working on her other business that she started. Lately Aimee had been working on search engine optimizician and she was getting results finally but today she hit "the wall"!
"Aimee, what is wrong?" asked Rachael.
As Aimee cried she said "I feel like I have been hiking on my trail and climbing the mountain and I was making good ground but I tripped and dropped all my precious gems. It feels like they flew out of my hands and went every where and I am just mad about it. I hit "the wall" Rachael."
"Ohhhh. Aimee….do not worry. We will just start to pick up your gems and get a process to put them in your pocket. Just dust your self off and get up. I will help you!" Rachael said.
"Search engine optimizician can be a stressful process and we need to figure out how to help you distress to help you move forward." Rachael said.
Do you ever feel like Aimee…You know you do!
Search engine optimizician can become stressful and there are two ways to kick that out.
Number ONE…Become Smart
Yes…Be smart, you hear it right!
Being smart means when you are working on getting search engine optimizician make it easy on your self.
Backlinks are a GREAT way to use SEO. Using Google buzz or yahoo bookmarking is a GREAT way to get started and it is EASY!
"Aimee, my mom gave me this GREAT tool to use that really helped me calm down when Adrian would cry almost all through the night, you do remember that right. I would call you crying at 2 am because Adrian was crying and would not stop?" asked Rachael
"OH YEAH!" said Aimee. "Well my mom got the this CD called Echoes of the Heart and not only did it calm me but Adrian would sleep better when it was playing." Rachael said "And I think it would help you get through the stressful times when you feel like you lost all you marbles."
"I lost my gems Rachael, NOT marbles." Aimee said.
"Oh yeah, Gems…RIGHT! Anyways my point is Aimee I think listening to Echoes of the Heart would bring you peace and help you focus on your work" Rachael said.
If you want peace and a little stress like Aimee you are going to HAVE to have Echoes of the Heart. It will help melt your stress away and help you focus on your next task at hand with your online business.
Happy Posting!
Megan Gasser
(The SEO Powerhouse)
Co Founder: www.theshortcutgroup.com The Shortcut Group – the easier way of getting things done
Founder: www.6stepseasyforyou.com Make your business easy…We LOVE easy!
Ambassador of Superior SEO for www.howtoliveonpurpose.com
"Success seems to be connected with action. Successful people keep moving. They make mistakes, but they don't quit." – Author Unknown
article source: http://feedproxy.google.com/~r/TheShortcutGroupSEOPowerhouse/~3/Y4VJmZkW3GY/


text:
- Age / Gender:
- 35, Male
- Location:
- Location not disclosed
- Joined:
- 12/15/11
- All Stats >
User Statshot
- Community Stats
Level 8 Blank Slate
Normal Whistle
Ranked as Civilian
Contact Info / Websites
Favorite Movies
Boobies Rated 4.3946 Stars 50 animators, so many boobs. Comedy - Original Vertical Seafood Taco Rated 4.4208 Stars It's eaten raw not fried, and turned upon its side... Music Video The Reward Rated 4.5153 Stars The Reward is a film about bromance, fantasy, killing stuff... and HIGH FIVES!! Comedy - Original Central Bwankers Rated 4.4459 Stars Central Bankers meet to decide the fate of the economy. Comedy - Original
Favorite Games
Doodle Devil Rated 4.4318 Stars Doodle Devil has been created to maintain balance in the Universe... Puzzles - Difference Time Fcuk Rated 4.4389 Stars Time is relative. Action - Platformer - Puzzle War of the Web Rated 4.2441 Stars War has broken out between Newgrounds, Kongregate, Armor Games, Facebook, and Jiggmin Strategy - Other Abobo's Big Adventure Rated 4.4281 Stars The Ultimate Tribute to the NES! Play as the angriest 8-bit character in the universe! Action - Other
Recent Game Medals
BE SOMEBODY 5 Points Run away, and begin your escape. Medal Stats.
GO BACK TO AFRICA 100 Points Yeah, you're gonna sit there and watch it again - AND THIS TIME, YOU BETTER LOVE IT. Medal Stats.
There and Black Again 50 Points Watch Africa Dudes twice in a row, black to black! (Without re-loading your window!) Medal Stats.
SECRET MEDAL 5 Points Unlock this medal to see it's details. Medal Stats.
Johari appear! 5 Points Get 5 clothes Medal Stats.
You began 5 Points you clicked on play game button Medal Stats.
Starting the Journey! 10 Points You started the game and walked! (And watched the ad) Medal Stats.
Fear 10 Points Kill a spider mini-boss Medal Stats.
Lab Rat 5 Points You woke up, you were flushed, you escaped... Medal Stats.
Fallen 5 Points Not by zombies :O Medal Stats.
Total Medals Earned: 629 (From 92 different games.)
Favorite Audio
|Ghostmas song
|Ambient Loop


text:
- SCU Home Page
- About SCU
- Admission
- Academics
- On Campus
- News & Info
- Alumni
- Web Publishing
- Redesign Project
- About Web Publishing
- Getting Started
- CommonSpot Help
- Design Resources
- Publisher Resources
- Contact Us
Display a Podcast RSS Feed
You can use the RSS Display element to include a Podcast feed in a Commonspot page, and embed an audio player for each item's audio file enclosure. In the example below, we're including the RSS feed for an iTunes U Podcast. Along with supplying the RSS feed URL as a custom script parameter, you'll want to set the "display" parameter to "full" in order to display the embedded player.


text:
Looks like a great start. I'm subscribed!
BTW, I tried to check out the forum for your car but it requires registration (which I'm not prepared to do) just to view your thread.
Hi guys, I've been reading these forums for a good couple of months now and I've finally started my carpc
I live in Sydney Australia, so my car is actually a 2002 Holden Astra TS Sedan but I've re-badged it back to an Opel
I guess I'll start with a photo of the car (I'm eventually putting a body kit on it, new rims, colourcoding etc, but wanted to get the carpc up and running first).
Now on with the PC:
This is what my Dash/console looked like (after I installed plasma dials, red and blue leds etc... everything was an ugly orange/yellow from stock, more info about my car in my car thread at opelaus.com):
I started to fabricate the console to install my 7" touchscreen monitor:
I installed the computer in my glove box, the console is still unfinished (needs more fill, sand, prime, paint), I just wanted to make sure everything was working:
When I first got it up and running, I installed Ride Runner, I've been using that and trialing Centrafuse trying to work out exactly what works for me:
I installed my GPS and WiFi dongles in the base of my rear view mirror. This isn't the stock mirror from an Astra, its a Auto dimming mirror from an Opel Vectra, so the base is larger and allows me to fit the USB HUB and peripherals inside it. I'm eventually going to put some black vinyl on the windscreen to hide the devices and keep it looking OEM:
I'll try and keep this worklog up to date as I build this thing.
Thanks for checking it out
Looks like a great start. I'm subscribed!
BTW, I tried to check out the forum for your car but it requires registration (which I'm not prepared to do) just to view your thread.
Last edited by PhilG; 10-30-2011 at 09:38 AM.
My 2007 Ford F350 Work Log located HERE
Relocated my hazard switch and added amp and pc hard off buttons
Painted the baby red
Installed reverse cam


text: We're sorry, Tan Cut Out Cushion is no longer available Why not try one of these instead? Biscuit Cushion by lisa angel homeware and gifts £22$49.38€32.86$36.19 free UK delivery Personalised Name Cushion Grey And Liberty... by Little Cloud £25$56.12€37.34$41.13 Personalised Name Cushion Pale Pink And Li... by Little Cloud £25$56.12€37.34$41.13 'Today Has Been Cancelled' Pillowcase by Minna's room £21$47.14€31.37$34.54 Tan Cut Out Cushion by Nancy Straughan - Printed Textiles £30$67.34€44.81$49.35 This item is no longer available £18.50$41.53€27.63$30.43 delivery to United States Receive this item 5-10 working days from dispatch International delivery available sizesize (required)35cm x 35 cm45 x 45 cm (+ £15)60cm x 60cm (+ £30)size (required)35cm x 35 cm45 x 45 cm (+ $33.67)60cm x 60cm (+ $67.34)size (required)35cm x 35 cm45 x 45 cm (+ €22.40)60cm x 60cm (+ €44.81)size (required)35cm x 35 cm45 x 45 cm (+ $24.67)60cm x 60cm (+ $49.35) we're sorry we're sorry, This item is no longer available buy a gift voucher related categories home > bedroom > decorative accessories > cushions > patterned cushions by Nancy Straughan - Printed Textiles Location: London, GB read seller's profile see seller's complete range you may also like PRODUCT DETAILS DELIVERY RETURNS Made in Britain eco-friendly save for later Natural linen and cotton blend cushion cover printed with my Cut Out design in the colour Tan. This beautiful organic cotton and linen cushion cover was designed and sewn by Nancy in her studio. Each cover is made using sustainable and organic fabric & inks, and is part of a limited product range that is produced in house. This envelope style cushion cover has been printed and made in the UK.Cushion covers do not come with an insert but inexpensive inserts are available from department stores. However if you would like the insert included please email for extra postage cost details. Every effort has been made to accurately portray the colours used in these fabrics, however individual monitor settings and other factors may cause discrepancies. As the fabrics are natural there may be very slight variations of the weave, but that is what makes natural fabrics so lovely. Due to the nature of the fabric a cool 30c wash is recommended. made from: Organic linen dimensions: 35cmx 35cm product code: 247536 This product is dispatched to you by Nancy Straughan - Printed Textiles. MAINLAND UK order now and receive this item by price Free Delivery Monday 7 December FREEFREEFREEFREE NON-MAINLAND UK estimated delivery price Highlands & Islands of Scotland 2-5 working daysfrom dispatch FREEFREEFREEFREE Northern Ireland 2-5 working daysfrom dispatch FREEFREEFREEFREE Other UK Islands 2-5 working daysfrom dispatch FREEFREEFREEFREE INTERNATIONAL DELIVERY estimated delivery price Western Europe 2-5 working daysfrom dispatch £11.50$25.81€17.17$18.91 Rest of Europe 5-10 working daysfrom dispatch £11.50$25.81€17.17$18.91 USA & Canada 5-10 working daysfrom dispatch £18.50$41.53€27.63$30.43 Asia & Australasia 5-10 working daysfrom dispatch £19.50$43.77€29.13$32.08 Rest of the world 5-14 working daysfrom dispatch £19.50$43.77€29.13$32.08 You have 28 days, from receipt of cancellable goods, to notify the seller if you wish to cancel your order or exchange an item. Please note: goods that are personalised, bespoke or made-to-order to your specific requirements, perishable products and personal items sold with a hygiene seal (cosmetics, underwear) in instances where the seal is broken are non-refundable, unless faulty. Read more about our returns policy.Should you choose to return or exchange your order you will need to deliver the item(s) to the UK, where this seller is based. Nancy Straughan - Printed Textiles's return policy Please see notonthehighstreet.com's returns policy.


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La porta sul buio: Season 1, Episode 1
Il vicino di casa (Sep. 1973)
Luca and Stefania are a young couple with a baby who move into a remote seaside apartment late at night. Unbeknownst to the couple, the neighbor who lives upstairs has just murdered his wife.
Director:Luigi Cozzi
Writer:Luigi Cozzi
Stars:Aldo Reggiani, Laura Belli, Mimmo Palmara | See full cast and crew »