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Tag:Big 12
Posted on: September 21, 2011 9:05 am
Edited on: September 21, 2011 9:07 am
The Pac-12 may have just saved the Big 12
By Jeff Goodman
The Pac-12 may have just saved the Big 12.
League commissioner Larry Scott announced late last night that the Pac-12 would remain a 12-team conference.
"While we have great respect for all of the institutions that have contacted us, and certain expansion proposals were financially attractive, we have a strong conference structure and culture of equality that we are committed to preserve," Scott said in a statement. "With new landmark TV agreements and plans to launch our innovative television networks, we are going to focus solely on these great assets, our strong heritage and the bright future in front of us."
There was a possibility that Texas, Oklahoma, Oklahoma State and Texas Tech were headed from the Big 12 to the Pac-12, which would have triggered wholesale changes on the conference landscape. That would have left the Big 12 extremely vulnerable with just Kansas, Kansas State, Missouri, Baylor and Iowa State.
Certainly, Texas and its new Longhorn Network had something to do with the fact that the Pac-12 opted against expansion. The league was adamant that the revenue would be split equally.
However, this decision by the Pac-12 doesn't mean this game of league musical chairs is over. They'll be more maneuvering, whether it be the ACC and Big East adding a couple more teams, the SEC grabbing one or even the Pac-12 - down the road - opting to expand.
But it's no longer complete mayhem.
The Pac-12 is still a league on solid footing without the four schools under consideration. Obviously, Texas would have heightened its profile - but the financial risk didn't outweigh the reward.
The Big 12 has nine members after Nebraska and Colorado already left and Texas A&M is headed to the SEC. It will likely try and pluck another school in order to get to 10.
The Big East would then likely stay together as a football-basketball league despite the impending losses of Pittsburgh and Syracuse. The conference sits at 15 schools with the addition of TCU, but there's still a possibility that a couple of its members - UConn and Rutgers being the prime candidates - go elsewhere.
So, while there's still movement on the horizon, the Pac-12's decision brought a little clarity to an arena in which it's clearly needed.
Category: NCAAB
Tags: Big 12, Big East, Jeff Goodman, Larry Scott, Pac-12, SEC
Posted on: September 20, 2011 5:22 pm
Myck Kabongo trying to crossover to rapping
Texas freshman Myck Kabongo might be the nation's best incoming point guard. He's also apparently the best rapper in college basketball.
Of course, we've all heard the basketball player-turned-rapper routine before. Kobe Bryant, Allen Iverson, Shaquille O'Neal, Ron Artest – they've all tried it. Aside from a catchy verse here and there, most athlete/rappers are fairly awful.
Kabongo is confident he won't be like that.
"When people hear the music, they'll see it's not just another basketball player trying to rap," Kabongo told Jason Jordan of ESPN.com. "I didn't want it to be corny or anything like that. It's really good and I guarantee that it'll be better than what people expect."
Kabongo, whose stage name is Yung Swag, is a Canada native who had one of the more infectious personalities in the class of 2011. That undoubtedly will help in his quest to be a successful rapper.
"It's just in me," Kabongo said. "It's something that I used to play around with and grew to really love. So I decided to do it for real."
Kabongo will release a 15-track album next spring entitled "Late Nights and Early Mornings." He has a feature from Kevin Durant on the album, which is sure to attract some extra attention to the album. Kabongo said it won't be for sale, but he will make it available for everyone to hear.
With features from Durant and a stamp of approval from Austin Rivers ("Everything I've heard from him goes hard. He's nice."), Kabongo could rival Tennessee's Renaldo Woolridge a.k.a. Swiperboy for the top dog in college basketball rapping.
Maybe someone can set up a freestyle battle – and a one-on-one game.
Photo: High School Hoop
Category: NCAAB
Tags: Big 12, Jeff Borzello, Myck Kabongo, Texas
Posted on: September 19, 2011 1:00 pm
Edited on: September 21, 2011 1:03 pm
Podcast: McMurphy hops on to talk what's next
By Matt Norlander
Who better to have on Monday's podcast than the man responsible for so much of the newsbreaking over the weekend? Our Brett McMurphy hopped on with me to talk about his reporting of the ACC/Big East mess and who/what/why is next. This conference talk is as much about reaction as it is prediction, so we ride both sides of that seesaw.
For instance, isn't the SEC a little too quiet right now? The conference sits at 13 teams. That can't last for long. Is the Pac-12 going to become the Pac-16 by week's end? How is Texas holding all of this up, and is the Longhorn Network just an albatross at this point?
McMurphy's blog should be in your daily rotation at this point. And follow him on Twitter. Guy's practically doubled his follower count in the past week. Love it. The 'Stache is mighty powerful these days.
If you please, here's the link for iTunes subscription. The podcast goes up a few minutes after it's live here on the blog, so be sure to subscribe. Or, if you're just hanging out, click the player below and enjoy.
Posted on: September 15, 2011 1:58 pm
Edited on: September 15, 2011 2:36 pm
Mario Chalmers talked 'sh-t' to Jay Wright
By Gary Parrish
My pal Jason King from Yahoo! Sports has a book coming out later this month. It's called "Beyond the Phog -- Untold Stories from Kansas Basketball's Most Dominant Decade," which means it's an easy Christmas gift for any and every KU fan. That's obvious. But it's going to be a worthwhile read for all followers of college basketball if there are more stories in it like the excerpt published today at KUSports.com.
The story is told by Mario Chalmers.
You might remember him from the 2008 national title game.
He's the guy who hit that shot that forced overtime against Memphis.
Anyway, before the Jayhawks beat Memphis in championship game they played Villanova in the Sweet 16. This was just another Sweet 16 game on the surface, but Chalmers said it was "personal" because Villanova's Jay Wright had previously cut Chalmers and Sherron Collins from a USA Basketball team of which he was the head coach.
I'll let Chalmers take it from here ...
So when it came to the Villanova game, Coach Self called Sherron and me into his office and said, "How do you feel about this Villanova game?" I said, "Coach, this is personal to me. I don't like Jay Wright." He was like, "I understand that, but keep it out of the media." So when the media asked if it was a personal game, we'd say, "No, it's not personal. It's just another game." But during the game we were talking all kinds of s--t to Jay Wright. We'd run by him and tell him, "Sit your ass down! We got this!" Another time we said to him, "This is what you get for cutting us. We're about to dog you!" Anytime we were throwing the ball in from the sideline, when he was standing up trying to call a play, we'd tell him to shut his mouth and sit down. There was one play where I threw a lob to Shady on an inbounds pass and he dunked over Scottie Reynolds. Right before I threw it I looked at Jay Wright and said, "Watch this!" That game was definitely personal for Sherron and me.
Photo: AP
Category: NCAAB
Tags: Big 12, Big East, Gary Parrish, Kansas, Mario Chalmers, Villanova
Posted on: September 15, 2011 10:49 am
Edited on: September 15, 2011 6:05 pm
Frank Haith gives first reaction to Yahoo story
By Matt Norlander
(UPDATE: Haith also spoke, a little more in detail, to Steve Walentik of the Columbia Daily Tribune and CBSSports.com. Worth the quick read. Click.)
Frank Haith isn't allowed to speak on the record about the allegations against he and his former staff at Miami. That's an edict from the NCAA, which is currently looking into Haith's past with the Hurricanes.
In August, Yahoo Sports dropped what I consider to be the most thorough investigative story in the history of sports journalism. It largely centered around the Miami football program, but Haith was a target as well. In fact, the allegations against he and his assistants were among the most acute and detailed. The primary allegation from imprisoned former Miami booster/Ponzi schemer Nevin Shapiro was that Haith arranged to pay recruit DeQuan Jones $10,000. Jones is still on Miami's roster, has been a player of minimal impact, and has yet to be punished for his alleged involvement.
Haith went on KTRS radio Wednesday night. Naturally, the Yahoo Sports story came up. Haith addressed it on record for the first time (not including a sterile reaction by way of a school press release). Good job by the hosts to get something out of Haith, when he's among the most guarded head coaches in the country to begin with.
The better quote, in my ears, is Haith addressing how he's dealing with a frenzied September of official visits and in-home conversations with recruits and their parents. This is a big month. Could arguably set the tone for his tenure at Missouri. He's got a reputation to overcome. That's not easy, obviously.
I'd love to offer up true context, but it seems KTRS' site is still a few days behind in uploading its notable audio clips.
Parrish has written about it here before. So long as Haith denies, denies, denies, and there's no paper trail, he's most likely not going to lose his job over this. Now, if he can't win at a high rate and his recruiting is affected? He could be bought out of that five-year contract well before it expires.
Photo: AP
Category: NCAAB
Tags: ACC, Big 12, Frank Haith, Matt Norlander, Miami, Missouri
Posted on: September 13, 2011 5:55 am
Edited on: September 13, 2011 6:00 am
Believe statements from the SEC at your own risk
By Gary Parrish
Mike Slive said on Monday that the SEC has "no immediate plans for a 14th member."
And that might be true.
But before we start preparing to watch a 13-school SEC -- i.e., the current members plus Texas A&M -- in 2012-13, I feel compelled to point out what Florida president Bernie Machen said less than a month ago after a meeting with fellow league presidents and chancellors.
"[We] met today and reaffirmed our satisfaction with the present 12 institutional alignment."
Again, Machen said that on Aug. 14.
The SEC voted to add Texas A&M just 23 days later.
The lesson?
We should all be careful about what we believe as this conference realignment story continues to change by the day. Don't forget that there's a reason most have long assumed the SEC would jump from 12 members to 14 members whenever it decided to jump, and a smooth-talking commissioner who specializes in semantics publicly suggesting otherwise isn't really a good reason to believe that still won't be the case.
Category: NCAAB
Tags: Big 12, Gary Parrish, SEC, Texas A&M
Posted on: September 7, 2011 9:46 am
Baylor is desperate and right at the same time
By Gary Parrish
Texas A&M's move from the Big 12 to the SEC is on hold until the SEC gets assurances that no Big 12 school will sue because, suddenly, at least one Big 12 school -- specifically Baylor -- is threatening to do exactly that. My question: Why would Baylor give such an assurance?
Baylor seems, at this moment, to have one foot in Conference USA and the other on something slippery as the college landscape shifts, and if that's the case isn't it only responsible for Baylor to try to scare the Big 12 into staying together by any means necessary? I have no idea if Baylor could win such a lawsuit against the SEC, commissioner Mike Slive and/or Texas A&M because I'm not a lawyer. But what I do know is that, in this country, you can threaten to sue pretty much anybody for pretty much anything, and if the SEC and A&M want that possibility off the table before moving forward then Baylor ought to make the SEC and A&M give something in return.
What something?
Could be anything, including straight-cash homey.
But it would be foolish to take the threat of a lawsuit off the table just because the SEC asks.
So good for Baylor for standing up.
Ultimately, the school's actions will probably only stall the inevitable.
But desperate shots are worth taking when you find yourself in desperate times.
Category: NCAAB
Tags: Baylor, Big 12, Gary Parrish, Mike Slive, SEC, Texas A&M
Posted on: September 1, 2011 2:03 pm
Edited on: September 1, 2011 4:55 pm
BYU to the Big 12: Can it happen? Should it?
By Matt Norlander
And the carousel spins again.
With Texas A&M's departure from the league, there's a scramble to see which program can be lured to keep the Big 12 not only alive and legitimate, but prosperous and afoot in the great college football race. As of right now, it appears the Big 12 has sprained one ankle while having its other foot lopped off. There aren't many schools with real cache that can get the Big 12 vital again and would want to join. Nebraska and Texas A&M, two of the five most relevant schools in the league, have now gotten out within a year's time.
And, yes, you're reading this on a college basketball blog. Football waves the wand, but these decisions do have impact in the second largest inter-collegiate sport.
BYU seems like they might be willing to flirt. Cougs in the Big 12. Hmm. Does it work? In order for that to happen, it's going to need promises and plenty of chatter with other schools. Specifically, the Big 12 needs to accurately advertise and get a dozen teams in its conference again. That way, a conference championship game in football can be held. That's paramount.
The funny part of this fledgling saga is how BYU is publicly acting so disturbed by having its name injected into expansion talks once again. Like the girlfriend that's cheated before and is stuck with that stigma, BYU's proven it will jump to a new conference, so it's just going to have to deal with that reputation. The school jettisoned the Mountain West last year and is currently an independent in football. All its other programs now reside in the West Coast Conference.
The Salt Lake Tribune's Jay Drew has a story out today that details BYU's ongoing disucssions with the Big 12, despite its claims to the contrary.
The Salt Lake Tribune has learned that BYU officials have had discussions with Big 12 officials within the past week regarding the school's interest in joining the conference, and what conditions and assurances it would need to make the jump exactly a year after announcing they were breaking away from the Mountain West Conference.
On the surface, if this is true, the Big 12 should probably not go to BYU's well, or at the very least look too desperate. Another school with a TV network and aspirations of separating its brand from the conference? That can't be good for league morale. BYU, a league newbie, would already have the upper hand over longtime members, even schools like Kansas, which has tremendous pull in basketball. BYU, like the Big 12, does have a deal with ESPN (who knows what kind of commitments are up in the air and how tangled that slinky is right now; that's an entirely different set of problems), so there could be arrangements negotiated there that could really hold things up.
Could it be football in the Big 12 and all other sports remain in the West Coast? A funky setup, but anything will be accommodated in the name of football. Right now, it looks like it's BYU ... then everything else. The Cougars, being independent, are on an island and the Big 12 will want to rope them in with the prospect of poaching two other schools (New Mexico? Houston? Memphis? Pulling TCU away from the Big East?) afterward.
Is the Big 12 ultimately doomed, though? Very well could be. Richard Justice's lede in his Houston Chronicle blog post today indicates he is on to something. Oklahoma can't be happy right now, and Oklahoma State should also be looking about moving West. The priorities for Big 12 officials right now need to be easing the mind of its current members while simulatenously and swiftly putting back together a league that's been waiting to buckle under its own weight for more than a year.
Category: NCAAB
Tags: Big 12, BYU, Matt Norlander


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If France wants to sell more cars they should LOWER their
taxes on fuel and Registration. Their doing everything to
prevent people from buying! Simple economics!
Must be Gerard Depardieu's fault.
Let's not forget that for the general public in France a car is a 'want', not a 'need', because France has an excellent Public Transportation system.
While exorbitant taxation on fuel, VAT on cars, expensive annual registration fees and personal luxury taxes play a vital role in a person's decision to buy or not to buy a car, parking space, or the lack of it, generally forces people to use Public Transportation to get where they are going.
It does not, however, prevent people from renting cars when they go on vaca. I have rented Simca, Peugeot and even Citroen cars while visiting France and found their rental-rates very competitive, in many case much cheaper by the week than in the US.
The younger generation in France is more interested in the latest smart phones and Tablets than they are in a new car.
Driver's Seat is a blog featuring news, views, and advice about cars, auto safety, driving, and transportation. Driver's Seat is written by Jonathan Welsh with contributions from auto critic Dan Neil, columnist Joe White and Wall Street Journal staffers and others.

subset: commoncrawl


text:
Lovin that wake and bake before my cheerios
when i wake up in the morning the first thing i wanna do is pack a bowl and smoke it. its just what i do and it just makes me comfortable...is that wrong? nah, its totally right...try it sometime before you wanna be a hater, promise that will be the best fucken cheerios you've ever had lmfao!
..:love, peace, and weed:..
Blazi3 Uploaded 05/11/2010
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text:
Manuel a hurricane after deadly Mexico flooding
MIAMI (AP) -- The U.S. National Hurricane Center says Manuel has become a hurricane with its northern eyewall now nearing the Pacific Coast of Mexico.
Forecasters say the deadly storm has strengthened and it has top sustained winds of 75 mph (115 kph). Manuel is centered about 20 miles (30 kilometers) southeast of the western Mexican community of Altata.
The center also says Manuel is moving north at 5 mph (7 kph) and a hurricane warning is in effect from La Cruz to Topolobampo in Mexico. Some strengthening is possible as it nears the coast.


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Pheedo's new report shows that position, frequency and feed content category affect RSS ad click-through rates.
Click-through rates for most standard online image ads have languished at less than one or two percent for years, but some ads placed in RSS feeds are garnering much higher CTR. The "Pheed Read Spring 2006" report released today by RSS and blog marketing firm Pheedo shows that the average CTR of "standalone" RSS ads is 2.76 percent, while "inline" RSS ads, or ads within an individual feed post, are getting a .45 percent CTR. The quarterly study looks at RSS ad and content CTR and how those rates are affected by position, frequency and feed content vertical.
According to Pheedo's December 2005 report, standalone RSS ads grabbed an average 7.99 percent CTR and inline feed ads got a .85 percent CTR on average. In the new study, these rates dropped 65 percent and 47 percent, respectively. The company believes that feed ad CTR will continue to normalize; however, Pheedo VP of Marketing Bill Flitter predicted, "I think it will be a much, much less significant drop going into the next quarter."
Ad frequency is a factor. Publishers that placed inline ads within every post saw an average 1.75 percent CTR. That number fluctuated as ads were staggered between every second and third post, and so on. Relatively higher click-through rates came from ads placed in every fifth post (1.56 percent), and every tenth post (1.09 percent).
"This is somewhat driven by publisher preference," observed Dana VanDen Heuvel, director of business development at Pheedo. He noticed that in recent months publishers have begun placing more ads in RSS feeds to boost ad revenue. "This is indicative of a shift in publisher savvy, publisher intelligence, as it relates to RSS. It illustrates publishers are trying to get the most revenue from their feeds," he added.
Feed content itself had an impact on ad CTR, too, according to the report. Ads placed within Comics and Humor; Travel; and Kids and Family feed content verticals spurred the most average CTR at 9.62 percent, 8.54 percent and 7.61 percent, respectively. Games; Arts and Literature; and Sports and Recreation came in at over 4 percent, while Politics and Consumer Technology got an average CTR of less than 1.5 percent.
According to Flitter, most RSS feed advertisers fall into the Auto, Consumer Electronics and Finance categories.
"There's a very small group that's currently using RSS feeds to advertise," said JupiterResearch Analyst Emily Riley. Most, she continued, are looking to target early tech adopters like Web developers, designers and others in technical fields.
The question remains: are RSS advertisers concerned with CTR more than other metrics for determining ad effectiveness? "It's based on the goal of the advertiser," said Riley. "If the advertiser is looking to increase click-through rates for whatever random reason than that would be great." Although she believes that ad impression and CTR are often used as initial ways to measure campaigns, most advertisers, including RSS feed advertisers, typically graduate to more sophisticated metrics like conversion, brand awareness and purchase intent.
The report findings may surprise those in the online publishing world who have debated which is best: distributing complete RSS feed content or a brief summary or introduction. On average, it was discovered, summary feeds got a median CTR of 8 percent, while full feeds garnered a 10 percent median rate. The truth is most RSS subscribers, 90 percent, read feed content in their news aggregator interfaces regardless of whether full or partial posts are published there.
"This is actually positive for advertisers," noted Pheedo's Flitter, "because they have a captive audience" within the news aggregator environment. VanDen Heuvel added, "This is going to be the consumption vehicle of choice."
Pheedo sampled 50 feeds for the study, 84 percent of which featured summary posts.
Kate Kaye was Managing Editor at ClickZ News until October 2012. As a daily reporter and editor for the original news source, she covered beats including digital political campaigns and government regulation of the online ad industry. Kate is the author of Campaign '08: A Turning Point for Digital Media, the only book focused on the paid digital media efforts of the 2008 presidential campaigns. Kate created ClickZ's Politics & Advocacy section, and is the primary contributor to the one-of-a-kind section. She began reporting on the interactive ad industry in 1999 and has spoken at several events and in interviews for television, radio, print, and digital media outlets. You can follow Kate on Twitter at @LowbrowKate.
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The issue of whether coelomates form a single clade, the Coelomata, or whether all animals that moult an exoskeleton (such as the coelomate arthropods and the pseudocoelomate nematodes) form a distinct clade, the Ecdysozoa, is the most puzzling issue in animal systematics and a major open-ended subject in evolutionary biology. Previous single-gene and genome-scale analyses designed to resolve the issue have produced contradictory results. Here we present the first genome-scale phylogenetic evidence that strongly supports the Ecdysozoa hypothesis.
Through the most extensive phylogenetic analysis carried out to date, the complete genomes of 11 eukaryotic species have been analyzed in order to find homologous sequences derived from 18 human chromosomes. Phylogenetic analysis of datasets showing an increased adjustment to equal evolutionary rates between nematode and arthropod sequences produced a gradual change from support for Coelomata to support for Ecdysozoa. Transition between topologies occurred when fast-evolving sequences of Caenorhabditis elegans were removed. When chordate, nematode and arthropod sequences were constrained to fit equal evolutionary rates, the Ecdysozoa topology was statistically accepted whereas Coelomata was rejected.
The reliability of a monophyletic group clustering arthropods and nematodes was unequivocally accepted in datasets where traces of the long-branch attraction effect were removed. This is the first phylogenomic evidence to strongly support the 'moulting clade' hypothesis.
Understanding the evolution of the great diversity of life is a major goal in biology. Despite decades of effort by systematists, evolutionary relationships between major groups of animals still remain unresolved. The inability to cluster taxa in monophyletic groups was originally due to the lack of morphological synapomorphies among phyla. An alternative solution came from embryology, and animal systematics relied on criteria based on increasing complexity of body plan [1]. Thus, the traditional metazoan phylogeny clusters animals from the simplest basal forms with loose tissue organization (for example, sponges) to those having two germ layers (dipoblastic animals, for example cnidarians), and those developing from three germ layers (triploblastic animals, such as the Bilateria - animals with bilateral symmetry). Bilateral animals were ordered into those lacking a coelom (the acoelomates, such as platyhelminths), those with a false coelom (the pseudocoelomates, such as nematodes), and, finally, those animals with a true coelom (the Coelomata, such as the arthropods and chordates). This comparative developmental theory of animal evolution dominated animal systematics for more than 50 years [2].
Subsequently, molecular systematic studies based on small subunit ribosomal RNA (18S rRNA) sequences began to undermine this scenario [1]. Put briefly, the new animal phylogeny suggested that clades such as acoelomates and pseudocoelomates are artificial systematic groups. Moreover, although the coelomate designation still remains, this clade now contains two new lineages: the lophotrochozoa and the Ecdysozoa [3]. The 'Ecdysozoa hypothesis' postulated that all phyla composed of animals that grow by moulting a cuticular exoskeleton (such as arthropods and nematodes) originate from a common ancestor, thus forming a distinct clade. Thus, under the Ecdysozoa hypothesis arthropods are genetically more closely related to nematodes than to chordates. Under the 'Coelomata hypothesis' of animal evolution, however, arthropods are more closely related to chordates than to nematodes.
At the heart of this systematic debate, a technical discussion emerged surrounding the long-branch attraction effect (LBAE), taxon sampling, and the number of characters used. Subsequent molecular and morphological studies have been carried out, but the controversy remains unresolved and is presented as a multifurcation [4]. Although the use of different single-gene sequences supported the Ecdysozoa hypothesis [5-11], the analysis of dozens to hundreds of concatenated sequences supported the Coelomata clade [12-15]. Indeed, with an element of caution, we favored the Coelomata hypothesis in a previous whole-genome study designed to determine the number of characters needed to obtain a reliable topology [16]. The gene-based Ecdysozoa versus genome-scale Coelomata alternative hypotheses were recently challenged by two phylogenomics studies that partly supported the Ecdysozoa clade [17] and a paraphyletic Coelomata group [18]. Although it is generally accepted that phylogenetic analysis of whole genomes has begun to supplement (and in some cases improve on) phylogenetic studies previously carried out with one or a few genes [19], all genome-wide phylogenetic studies have failed to support the proposed new animal phylogeny.
Here we present the first phylogenomic evidence that strongly supports the Ecdysozoa hypothesis and at the same time demonstrates that the LBAE biases the position of Caenorhabditis elegans in the phylogenetic tree. We show that by using a large number of characters and choosing a phylogenetic weighted scheme of outgroups to test the constancy of evolutionary rates, the new animal phylogeny can be statistically supported. Moreover, we show that both the Coelomata and the Ecdysozoa hypotheses can be supported with the highest statistical confidence when genomic datasets are ordered according to a gradually increased adjustment to equal evolutionary rates between C. elegans and Drosophila melanogaster sequences. In between, neither Ecdysozoa nor Coelomata were sufficiently supported. To our knowledge, this is the most extensive phylogenomic analysis carried out to date in the number of characters and the number of eukaryotic species involved.
Dataset properties
Sequences homologous to human exon sequences were derived from filtering tblastn search results on 11 complete eukaryotic genomes. Because the most-criticized issue in resolving the Ecdysozoa-Coelomata problem seems to be the LBAE produced by the nematode species, we decided to rearrange homologous sequences in a series of nested datasets that gradually reduced LBAE. Aligned homologous sequences were arranged in eight datasets (Di) and concatenated in their corresponding matrices (Mi) (see Materials and methods), such that as suffix i increases, datasets and matrices comprise a smaller number of homologous sequences showing more similar relative branch lengths (RBL) between C. elegans (LCe) and D. melanogaster (LDm) (Figure 1). RBL are relative human distances.
Figure 1. Description of the dataset. Di datasets are arranged according to a gradual decrease in the parameter δ. δ controls the inclusion of each homologous exon sequence in the dataset by defining margins above and below (y = x ± δ) a diagonal line (y = x) that constrains clock-like behavior in the evolution of C. elegans and D. melanogaster sequences. LCe and LDm are the respective relative branch lengths of C. elegans and D. melanogaster using H. sapiens as reference. Comma-separated values represent the number of homologous sequences and characters aligned in the Mi concatenated matrix. Di contains all the sequences without any constraint of evolutionary rates. Dotted black and red lines represent mean , and median values, respectively.
To quantify the effect on the RBL of C. elegans of concatenating alternative homologous sequences, maximum likelihood (ML) estimates of branch length were obtained using the star-like unrooted tree transformation for each dataset (see Materials and methods). Figure 2a shows that the RBL of C. elegans over D. melanogaster decreased by approximately 30% continuously from dataset D1 to D8. To test whether the gradual decrease in C. elegans branch length was enough to produce statistical confidence on equal evolutionary rates between the nematode and the arthropod sequences, relative rate tests using two outgroup schemes were assayed on concatenated sequences (see Materials and methods). Figure 2b shows that using Saccharomyces cerevisae as the unique outgroup species (OUG1), all the individual tests on the eight matrices failed to detect statistical deviations (at the 5% level family-wise) between sequences. Only when the phylogenetically weighted scheme of outgroup species (OUG2) was used did the relative rate test detect significant deviation of clock behavior from D1 to D5 datasets. We are therefore confident that the arthropod and nematode concatenated sequences of the M6, M7, and M8 matrices meet the desired clock-like conditions to test the Coelomata and Ecdysozoa hypotheses and exclude any artifacts derived from a possible LBAE. This result supports previous work suggesting that the genetic distance between ingroup and outgroup modifies the power of the relative rate test [20].
Figure 2. Relative rate test. (a) Relative C. elegans branch lengths derived from each one of the eight Mi matrices. Maximum likelihood estimates are expressed as relative distance units of D. melanogaster. (b) Relative rate test probability values evaluated at the 5% level family-wise (red line 1.7%). OUG1, S. cerevisae; OUG2, phylogenetic weighted scheme using S. cerevisae, A. thaliana, O. sativa and P. falciparum as outgroup species.
To test whether concatenated matrices carry sufficient phylogenetic signal, the ML mapping method was used. The compound posterior probability point (P) for all the possible quartets of each Mi matrix could be placed, with almost equivalent values (approximately 33%), inside the corner areas of the equilateral triangle probability surface (see 1). Thus, concatenated matrices derived from selecting a different number of homologous sequences contained sufficient phylogenetic signal to represent topologies as strictly bifurcating trees. Finally, using the Akaike information criterion (AIC) [21], the statistical test of the best-fit model of sequence evolution for each dataset was selected from six different alternatives (see Materials and methods). As all the models are not nested and share the same number of parameters, the best one was that with the greatest log likelihood result. The WAG amino-acid replacement matrix [22] adjusted for frequencies (+F), rate heterogeneity (+Γ) and invariable sites (+I) was the best evolutionary model chosen for all the datasets. Moreover, model-fit-data values followed the same inequality independently of the dataset (WAG [22] > VT [23] > BLOSUM62 [24] > JTT [25] > PAM [26] > mtREV24 [27]), suggesting that the best models were those that consider more distantly related amino-acid sequences.
The clade Coelomata disappears under clock conditions
Distance and ML phylogenetic methods were used on all the datasets (see Materials and methods). Figure 3 shows phylogenetic reconstructions and statistical support for the two extreme conditions of the nested datasets. Whereas the M1 matrix supported the Coelomata tree with the highest statistical confidence, M8 showed the same result for the Ecdysozoa tree. Thus, by decreasing the RBL of C. elegans, the statistical support switched from the Coelomata to the Ecdysozoa hypothesis. Figure 4 shows that, whichever phylogenetic method was used, C. elegans bootstrap support between datasets and topologies changed in agreement with the gradual RBL decrement. Specifically, using M1 and M8 (the matrices showing the most extreme evolutionary rate conditions for C. elegans and D. melanogaster sequences - from a clock-absent to the most adjusted behavior), the statistical support moved from Coelomata to Ecdysozoa. The same occurred with M2 and M7. Alternatively, using M3 and M6, only one of the two distance and ML methods (Figure 4a,b) provided sufficient support (90% or more) to the hypothesis. Finally, using M4 and M5, only one distance method supported Coelomata and Ecdysozoa with confidence. Given that datasets differed principally in the RBL of C. elegans over D. melanogaster, the gradual change in topology strongly favors an LBAE between C. elegans and the more basal species. To test whether a paired-sites test [28] supports the bootstrap conclusions, Shimodaira-Hasegawa (SH) and expected-likelihood weight (ELW) tests were evaluated on the datasets (see Materials and methods).
Figure 3. Phylogenetic trees. Trees derived from M1 and M8 datasets, respectively support (a) the Coelomata and (b) the Ecdysozoa hypothesis. From left to right or top to bottom, values besides nodes show the maximum likelihood reliability values of the quartet-puzzling tree and bootstrap values using maximum likelihood, least squares, and neighbor-joining methods, respectively. Values in red show the support for (a) Coelomata and (b) Ecdysozoa nodes. Red branches display distances between C. elegans and D. melanogaster. Smaller trees are minimal representations of both hypothesis.
Figure 4. Bootstrap and reliability support for alternative topologies. Bootstrap and reliability support (50% majority consensus rule) for Coelomata (C) and Ecdysozoa (E) hypotheses derived from each one of the eight Mi matrices. (a) Distance methods. LS, least squares; NJ, neighbor joining. (b) Maximum likelihood, using PHYLIP (ph) and PUZZLE (pz). Highly supported trees were considered those with values above 90% (dotted red line).
Figure 5 shows the assessment of paired-sites tests for the two competing trees on all the datasets. Paired-sites tests supporting topologies (p > 0.05) changed almost gradually on datasets. Figure 5a and 5b show that the SH test is more conservative than the ELW [29]. Using matrices M1 and M2, both tests strongly rejected the Ecdysozoa hypothesis, whereas M6, M7, and M8 rejected the Coelomata tree. Interestingly, datasets between them did not reject any topology with sufficient statistical evidence. We can conclude that by decreasing the RBL of C. elegans over D. melanogaster by around 13% (Figure 2a) the LBAE favoring the Coelomata hypothesis disappears and we can confirm that under strict conditions of clock-like behavior, the Coelomata hypothesis was strongly rejected by paired-sites tests and bootstrap support.
Figure 5. Paired-sites tests. p-values inferred from paired-sites tests considering Coelomata (C) and Ecdysozoa (E) hypotheses at the 5% level (red line) for all the datasets. (a) Shimodaira-Hasegawa test (SH); (b) expected-likelihood weight method (ELW).
To test if the shortness of the evolutionary distances between C. elegans and D. melanogaster resulting from the above filtering method biased topology over the common ancestry of arthropods and nematodes, we searched for chordate, arthropod, and nematode sequences showing clock-like behavior between them. To increase the probability of finding sequences to fit the criteria, we focused on sequences from the most closely related chordate to the molting species, that is, the ascidian Ciona intestinalis. Only 14 exon sequences met the above criteria. A relative rate test showed that the probability of a perfect clock-like behavior was p = 0.515 for C. elegans and D. melanogaster, p = 0.308 for C. intestinalis and D. melanogaster and p = 0.712 for C. intestinalis and C. elegans. The ML mapping method showed that the concatenation of all the 810 characters carried sufficient phylogenetic signal in the matrix to represent a strictly bifurcating tree (see Additional data file 2). Despite the reduced number of characters, phylogenetic analysis showed significant support for the Ecdysozoa hypothesis. Using distance and ML methods, bootstrap values reached 97%. Moreover, the Ecdysozoa hypothesis was accepted with a probability of p = 1.00 and p = 0.997 when SH and ELW paired-sites tests, respectively, were performed. Conversely, the Coelomata hypothesis was rejected at p = 0.006 and p = 0.0023, respectively.
The clade Coelomata disappears by removing fast-evolving sequences of C. elegans
In order to discard a probable biased selection of exon sequences favoring the Ecdysozoa hypothesis, two additional matrices were built by removing from the original dataset (D1) the exons in which the C. elegans sequences evolved at a faster rate. Figure 6 shows that by removing the fastest 15% of total exon sequences the reliability of the Coelomata hypothesis is reduced from 100% to 78%. Moreover, when the fastest 30% of all exons were removed, the topology changes to Ecdysozoa with 90% confidence level. The change in topology in parallel with the reduction of the C. elegans branch length points to the LBAE as the main obstacle to obtaining the true phylogenetic relationship between chordates, arthropods and nematodes. We conclude that the Ecdysozoa hypothesis does not depend on adjusting a particular set of homologous exon sequences to clock-like behavior.
Figure 6. Removing fast-evolving sequences. Exon sequences of C. elegans showing LCe ≥ = 4.06 represent 15% of the total exon. When these faster exons were removed (above blue line), support for the Coelomata topology was reduced from the original 100% to 85%. Furthermore, when 28% of the faster exons were deleted (red line), Ecdysozoa is recovered with 90% statistical support. This suggests that LBAE is the main problem in obtaining the Ecdysozoa tree. Blue line, = 4.06; red line, = 2.66.
There are many reasons why the Coelomata-Ecdysozoa problem should be considered the most puzzling problem in animal systematics and a major open-ended subject in evolutionary biology. The monophyly of the Ecdysozoa group, strongly championed by the evo-devo community [30], was originally deduced, and continually recovered, through the analysis of different single-gene sequences [3,5,6,8-11], sometimes in combination with morphological characters [7]. There is need for caution, however, as previous studies had shown that individual genes are not sufficient to estimate the correct genome phylogeny [19,31]. Furthermore, the reliability of some of the phylogenetic markers used to derive Ecdysozoa has been seriously questioned [32,33]. Those that consider the Ecdysozoa hypothesis as more plausible insist that the Coelomata topology is an artifact of LBAE, derived from the fact that nematode genomes, particularly that of C. elegans, evolve at higher rates [3], and are consequently displaced to a more basal position.
On the other hand, as phylogenetic reconstruction assumes that sampled data are representative of the whole genome from which they are drawn [34], there is increasing agreement to consider genome-scale analysis more accurate than single-gene analysis when deciding between conflicting topologies [19,31]. Conflict derives from the fact that all previous genome-wide phylogenetic attempts to test the hypothesis have failed to confirm the 'moulting group' - the Ecdysozoa - as a clade. All phylogenomic analyses carried out to date favor the Coelomata hypothesis with the highest statistical support [12-16]. Furthermore, the Coelomata tree has shown to be robust to criticism deriving from LBAE [12,14-16] and nematode species inclusion [14]. Those that consider the Coelomata hypothesis to be more appropriate insist that longer sequences, rather than extensive taxon sampling [35], will more effectively improve the accuracy of phylogenetic inference [14,15,36,37], and emphasize that an inevitable trade-off exists between the number of characters and the number of species used in the study [15].
We show here that by using the fast-evolving nematode C. elegans the Ecdysozoa can be recovered using genome-scale phylogenetic analysis. Our analysis has been performed over the largest number of eukaryotic genomes and over the largest number of amino-acid residues ever used to test the hypothesis. The major differences from previous genomic approaches are threefold. First, we used a large number of short conserved sequences (around 50 amino acids long) derived from human homologous exon sequences. Only exon sequences derived from eight genes, out of a total of around 100 analyzed by Blair et al. [14], were used in our analysis. The remaining genes contained in the 18 human chromosomes did not pass the BLAST filters applied in the analysis. Second, we arranged the dataset such that the sequences, including those evolving faster or slower, were included if they met the condition of equal rate of change between two (C. elegans and D. melanogaster) or three species (C. intestinalis, D. melanogaster and C. elegans). Third, we used a large number of characters (amino-acid residues) and a weighted distant outgroup species to enhance the power of the relative rate test [20].
As discussed in our previous paper [16], by including or excluding certain human homologous exon sequences, we reduced the problem of LBAE and added a probable bias favoring Coelomata. The present work confirms that this bias exists. The concatenation and the posterior phylogenetic analysis of the sequences shared by the eukaryotes used in this analysis provide a viable solution to the ancestor-descendant relationships of animal species once the LBAE is removed.
Acceptance of the new animal phylogeny and the Ecdysozoa hypothesis would provide a new scheme to understand the Cambrian explosion [38,39] and the origin of metazoan body plans [9,30] and consequently would set a new phylogenetic framework for comparative genomics [40]. We have shown how phylogenetic reconstruction based on whole-genome sequences has the potential to solve one of the most controversial hypotheses in animal evolution: the reliability of the Ecdysozoa clade.
Materials and methods
Dataset collection
Complete genome sequences from Plasmodium falciparum [41], Arabidopsis thaliana [42], Oryza sativa [43], Saccharomyces cerevisae [44], Caenorhabditis elegans [45], Anopheles gambiae [46], Drosophila melanogaster [47], Ciona intestinalis [48], Fugu rubripes [49], Mus musculus [50] and Homo sapiens [51] were downloaded and formatted to run local BLAST [52]. Amino-acid sequences corresponding to all the gene exons in a sample of 18 human chromosome including 6-18, 20-22, X and Y (approximately 14,000 genes and 140,000 exons), were obtained from the Ensembl database project [53]. Human paralogous exons were excluded by running local blastp [52] on a human exon database built ad hoc. Only the best of those sequences, with more than a single hit with a fraction of aligned and conserved amino-acid sequence ≥ 95% and ≥ 90% respectively, were retained to find homologous sequences in the other eukaryotic species (threshold values based on a previous human paralogous study [54]). We used tblastn [52] that searches a query amino-acid sequence on the six translation frames of the target sequence to search for homology in the complete genome databases of the species mentioned above. Exons less than 22 amino acids were removed from the analysis. Each best hit of tblastn was filtered by means of a threshold e-value (≤ 1e-03) and a threshold proportion of the query over the subject sequence length (≥ 75%). Only those exons that pass through all the species filter conditions were selected as the final dataset of human exon homologous sequences. All the exon homologous sequences were aligned using Clustal W [55] with default parameters. The total number of homologous sequences, derived from 18 human chromosomes, corresponds to 1,192 exons selected from 610 known genes, adding up to more than 55,500 amino-acid characters.
To arrange homologous sequences in different datasets, pairwise distances between sequences were extracted using the PROTDIST program (Kimura option) of the PHYLIP package [56]. Distances between C. elegans, D. melanogaster and H. sapiens were transformed into branch lengths in a star-like unrooted tree (la = (dab + dac - dbc)/2, where la is the length of the branch leading to a and dab, dac, dbc are the distances between a and b, a and c, and b and c, respectively). It is important to emphasize that we are not considering that the phylogenetic relationships of C. elegans, D. melanogaster and H. sapiens is a star topology. We used this exact equation for determining the branch lengths of the three species, because the unique way to arrange three species in a phylogenetic tree is a star topology. We consider C. elegans, D. melanogaster and H. sapiens to be members of the ingroup and P. falciparum, A. thaliana, O. sativa and S. cerevisae as the outgroup species at the moment to root the phylogenetic tree. Homologous exon sequences were arranged in eight datasets according to their pertinence to more inclusive areas surrounding the straight line representing identical relative branch lengths (RBLs) of C. elegans (LCe = lCe/lHs) and D. melanogaster (LDm = lDm/lHs). The Di dataset clusters all the homologous exon alignments where LDm - δi ≤ LCe ≤ LDm + δi, where i is an integer ranging from 2 to 7 and δi = 5.0, 3.0,2.5,2.0,15,1.0,0.5. The D1 dataset contains all the exon homologous sequences without the constraints of evolutionary rates. Exons with negative or undefined normalized distances (lHs = 0) were excluded from the analysis. All the aligned homologous exon sequences of the Di dataset were concatenated in the Mi matrix. Three additional matrices were derived from D1: two by removing exons containing LCe ≥ and LCe ≥ , and the last one by adjusting the sequences of C. intestinalis, D. melanogaster and C. elegans to clock-like behavior.
Phylogenetic methods
The relative rate test was performed at the 5% statistical level by means of the RRTree program [57] using outgroups with one (S. cerevisae; OUG1) or more species (S. cerevisae, A. thaliana, O. sativa and P. falciparum; OUG2). In the latter case, an explicit weighted phylogenetic scheme was chosen (1/2 S. cerevisae, ((1/8 A. thaliana, 1/8 O. sativa), 1/4 P. falciparum)). Given that three ingroups were set for all analyses (the chordates H. sapiens, M. musculus, F. rubripes, and C. intestinalis; the arthropods Anopheles gambiae and Drosophila melanogaster; and the nematode C. elegans), the threshold value was corrected for multiple testing to 5/3 = 1.7%. TREE-PUZZLE [58] was used to evaluate six alternative evolutionary models adjusted for frequencies (+F), site rate variation (+Γ distribution with two rates) and a proportion of invariable sites (+I), to estimate the amount of evolutionary information of datasets by the likelihood-mapping method [59], to derive the maximum likelihood (ML) trees using the quartet-puzzling algorithm, to set the ML pairwise sequence distances, and to test alternative topologies using SH [60] and ELW [29] tests. The PROML (JTT+f) program of the PHYLIP package [56] was used to estimate ML trees derived from the stepwise addition algorithm. Distance methods of phylogenetic reconstruction were performed using PROTDIST (JTT, Kimura options), NEIGHBOR (neighbor-joining (NJ) [61]) and least squares (LS) [62] algorithms, and CONSENSE (50% majority-consensus rule option) programs on 100 bootstrap replications using PHYLIP.
Additional data files
The following additional data files are available with the online version of this paper. Additional data file 1 contains a figure showing ML puzzle mapping of the Mi matrices. Additional data file 2 contains a figure showing ML puzzle mapping of the matrix derived from chordate, arthropod and nematode sequences showing clock-like behavior. Additional data file 3 contains the matrices.
Additional File 1. ML puzzle mapping of the Mi matrices. Maximum likelihood mapping results for each one of the Mi concatenated matrices. From the first row and from left to right, M1 to M2 until the fourth row, M7 to M8.
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Additional File 2. ML puzzle mapping of the matrix derived from chordate, arthropod and nematode sequences showing clock-like behavior. ML mapping of the concatenated matrix derived from constraining sequences to 3 clocks-like behavior.
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Additional File 3. Matrices. The full set of matrices (phylip format) used in the phylogenetic analyzes.
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We thank especially Javier Santoyo and the Bioinformatics department members at the Centro de Investigación Príncipe Felipe. We thank J. Castresana, D. Posada and R. Zardoya for comments and suggestions, and M. Robinson-Rechavi for updating the code of the RRTree software. Special thanks goes to Amanda Wren for her revision of the English. H.D. acknowledges the support of Fundación Carolina and Fundación la Caixa.
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The Department of Public Safety / Police is centrally located on the Columbus campus, on the ground floor of Delaware Hall, Room 047, between the cafeteria and the fitness center. The front lobby entrance faces the Columbus statue area.
The office and walk up service window is open daily from 7:30 a.m. to 11:00 p.m. Phones are answered 24/7.
Department Roster and Specialty Assignments
S. Asbury, Chief of Police (Homeland Security Liaison)
Police Lt. K. Smith, CLEE
Police Lt. D. Werner
Police Lt. D. Williard
Police Lt. S. Schemine
Safety & Security Coordinators
A. Farah, Security Coordinator-Delaware Campus
Security Specialists
E. Breece, Security Specialist
L. Bryom-McClure, Security Specialist
E. Crosby, Security Specialist
R. Harris, Jr., Security Specialist
S. Murphy, Security Specialist
Special Services
F. Sugar Special Services Coordinator; Purchasing & Invoice processing, Special Event support
Emergency Management
J. Smith Support and Preparedness Coordinator
Sergeants and Police Officers
Sgt. C. Kerns
Sgt. T. Lewis
Sgt. D. Sopraseuth
Ofc. T. Anderson (Crisis Intervention Team (CIT)
Ofc. C. Bryant
Ofc. G. Capers
Ofc. A. Carter
Ofc. B. Cramer
Ofc. W. Damron
Ofc. L. Diamond
Ofc. J. Dodge
Ofc. M. Hale
Ofc. C. Miller
Ofc. J. Murphy
Ofc. N. Rice
Ofc. S. Scott
Ofc. R. Lloyd
Ofc. B. Thomas (Property/Evidence)
Communications 614-287-2525
B. Hickman (Dispatch Sergeant/LEADS Agency Coord)
D. Alex (Communications Technician/LEADS Tech)
S. Anderson(Communications Technician/LEADS Tech)
C. Carothers (Communications Technician/LEADS Tech)
B. Diles (Communication Technician II/LEADS Tech)
F. Douglas, (Communications Technician/LEADS Tech)
B. Hamilton (Communications Technician/LEADS Tech)
K. Hamilton (Communications Technician/LEADS Tech)
S. Hollinshead (Communications Technician/LEADS Tech)
C. Rader (Communications Technician/LEADS Tech)
- Public Safety / Police
- Safety Tips
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- Parking
- Emergencies
- Reporting Incidents
- Resources
- Daily Crime Log
- Clery Annual Security Report
- Clery Crime Alerts
- RAVE Text Message Alerts
- Sex Offender Notification / eSORN Database
- Contacts
- Lost and Found
- Crime Prevention
- Facility Key & Card Access Requests


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Archived Issues
All issues of Inside Integrative Medicine newsletter are in PDF format.
- November Handling Holiday Stress: The Importance of Mind-body Practices
- October Compassion: The Heart of Healthcare
- September Planting the Seeds for a Healthy Lifestyle
- August An Integrative Approach to Cancer Care
- July Managing Stress to Improve Your Cancer Outcomes
- June Couples Coping with Cancer Together
- May Coping Techniques for Distress in Cancer Patients
- April Exercise: Part of an Integrative Approach to Cancer Care
- March Yoga for Body and Mind Health
- February Cancer Related Fatigue and How Integrative Therapies Can Help
- January A Trusted Resource for You
- December Getting to the Point with Acupuncture
- November Caring for the Caregivers
- October Pink is the star of October in honor of Breast Cancer Awareness Month.
- September What's New at the Integrative Medicine Center?
- August Fact or Fiction? Identifying Reliable Integrative Medicine Resources
- July Q&A With the Expert: Catherine Powers-James, Ph.D, Licensed Clinical Psychologist
- June Omega 3's in Cancer Prevention and Treatment
- May Music Therapy: A Melodic Approach to Treatment
- April Oncology Massage: Improving Your Quality of Life
- March Meditation is the Medicine of the Mind
- February Step up to Exercise!
- January Bite by Bite: Shopping Tips for Cancer Prevention and Optimal Health
- December Compassion and Cancer Care: A Strong Back and a Soft Front
- November How Can Acupuncture Complement Your Treatment?
- October Nutrigenomics: The Future of Personalized Nutrition in Cancer Prevention and Treatment
- September Expanding Services to Improve Outcomes
- August Cancer Patients Tune in to Music Therapy
- July Spirituality and the Cancer Patient
- June The Comprehensive Lifestyle Study: Examining an Integrative Oncology Approach
- May Manage Your Stress Before It Manages You
- April Environmental Factors and Breast Cancer
- February Let Food be Your Medicine: Diet and Cancer Prevention
- January Six Tips for Finding a Qualified Oncology Massage Therapist
- December: Tai Chi – Moving Meditation to Improve Quality of Life
- November: The Role of Soy Food and Breast Cancer
- October: Mindful Eating: Cultivating Your Inner Gourmet
- September: Center Welcomes Two New Team Members
- August: Cancer Survivors Should Keep Moving
- July: Talk to Your Medical Team About Complementary and Alternative Medicines
- June: Depression and the Importance of Mood
- May: Omega-3 Fatty Acids: Their Role in Cancer Prevention and Treatment
- April: Medical Hypnosis Demystified
- March: Whole Foods or Supplements?
- February: Meditation reduces stress and cultivates inner peace and well-being
- January: The Power of Touch: Oncology Massage
- August/September
- June/July
- April/May
- February/March
- December/January


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In February of 2011, Cameron and then-boyfriend Alex Rodriguez hung out with Diddy in Dallas. According to Us Weekly, the actress will "booty call" Diddy whenever she's single, which she has been since calling it quits with A-Rod in September. As for Diddy's girlfriend of three years, singer-model Cassie, 25, an insider recently told the mag, "Diddy's single whenever there's a better offer on the table!"
© 2015 Whalerock Industries


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Three Down, One More Night – Our Recommended #UMS2014 Day 4 Lineup
by Billy • July 27, 2014 • NewsThreads • 1 Comment
One. More. Day. Much more music! If you're still walking today, or, like so many of us, reaching for that hair of the dog to keep going ONE. MORE. DAY., we applaud you. We're starting our Sunday lineup late … after getting in some well-needed log-sawing….. Nonetheless, here's our Day 4 recommendations. Now leave...Read more →


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|Acute lymphoid leukemia associated with Maffucci's syndrome.
MedLine Citation:
|PMID: 8214367 Owner: NLM Status: MEDLINE
|PURPOSE: Maffucci's syndrome is a nonhereditary congenital disorder associated with multiple enchondromas, soft tissue hemangiomas, or lymphangiomas. It carries an associated high risk of the development of malignant neoplasms, particularly sarcomatous transformation of an enchondroma, as well as other malignant mesodermal and nonmesodermal neoplasms. Hematopoietic malignancies arising in Maffucci's syndrome are exceedingly rare. We report the case of a 14-year-old girl with Maffucci's syndrome who developed acute lymphoid leukemia. PATIENTS AND METHODS: The patient presented at 18 months of age with enchondromatosis. Maffucci's syndrome was established at 10 years of age after the appearance of multiple hemangiomas. RESULTS: At 14 years of age the patient developed fatigue, frequent nosebleeds, easy bruising, and weight loss, with circulating blasts in the peripheral blood. Bone marrow examination showed replacement of marrow spaces with leukemic blasts. Immunohistochemical and flow cytometric findings were consistent with a diagnosis of acute lymphoblastic leukemia with myeloid antigen expression. CONCLUSIONS: The occurrence of acute leukemia in a patient with Maffucci's syndrome may represent predisposition to yet another malignancy and reflect further expression of a generalized mesodermal dysplasia in these patients. It also emphasizes the need for aggressive surveillance in patients with Maffucci's syndrome.
|J T Rector; C L Gray; R W Sharpe; F W Hall; W Thomas; W Jones
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Publication Detail:
|Type: Case Reports; Journal Article
Journal Detail:
|Title: The American journal of pediatric hematology/oncology Volume: 15 ISSN: 0192-8562 ISO Abbreviation: Am J Pediatr Hematol Oncol Publication Date: 1993 Nov
Date Detail:
|Created Date: 1993-11-19 Completed Date: 1993-11-19 Revised Date: 2007-11-15
Medline Journal Info:
|Nlm Unique ID: 7908071 Medline TA: Am J Pediatr Hematol Oncol Country: UNITED STATES
Other Details:
|Languages: eng Pagination: 427-9 Citation Subset: IM
|Department of Laboratory Medicine, Naval Hospital, San Diego, California 92134-5000.
Export Citation:
|APA/MLA Format Download EndNote Download BibTex
|MeSH Terms
Antigens, CD / blood
Bone Marrow / pathology
Enchondromatosis / complications*, pathology, radiography
Hemangioma / complications, pathology
Lymphocytes / immunology
Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood, complications*, immunology, pathology
Skin Neoplasms / complications, pathology
Reg. No./Substance:
|0/Antigens, CD
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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You may have heard of the the Firefox Build Your Own Browser Project. On the web page, it says it "is a simple way that your organization can create and distribute a customized version of Firefox." I think BYOB is a great start to solving the distribution problem, but it's missing one key thing - the ability to bundle your own add-ons.
What I'm going to do with this post is explain exactly how BYOB works internally so that you can create your own distribution that has all the customizations you want. There are a some downsides to our method - primarily that we are Windows only and that we can't sign our installers with the Mozilla certificate. But it's the only way we can create a distribution that includes our own add-ons.


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Uploading Photos to gallery
Started Nov 10, 2010 | Discussions thread
Shop cameras & lenses ▾
If the first post was a question and a comment to second, it works with Firefox too.
MiLei's gear list:MiLei's gear list
Canon EOS 5D Canon EF 50mm f/1.4 USM Canon EF 70-200mm f/2.8L IS USM Tamron SP AF 200-500mm F/5-6.3 Di LD (IF) Sigma 70mm F2.8 EX DG Macro +2 more
Reply Reply with quote Complain
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|Nov 10, 2010
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Accusations abound that Dems have "tampered with Tea Party" in 4 states.
"The accusations range from helping tea party activists circulate candidate petition sheets to underwriting the creation of official Tea Parties, which then put forth slates of candidates that local conservatives accuse of being rife with Democratic plants. "
That's a quote from a Politico story concerning more than 6 races in 4 states; MI, FL, NJ, PA. These are not the typical "he stole my yard sign" accusations. Straw man candidates have been used before but there appears to be a concerted effort to undermine some very close races and the lid is coming off.
Its a 3 page story but well worth the read if you are involved in any of these races or in the tea parties. Be mindful it doesn't happen in your states.
Read more: http://www.politico.com/news/stories/0810/40699.html#ixzz0vl9BwUXd


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Rowan Pennink has his work cut out for him, but he's hanging in there.
Aside from the one race where he was tied for the points lead, Pennink has set firmly in second place in championship standings throughout the first half of the 2013 NASCAR Whelen Modified Tour season. And despite the many headlines that points leader Ryan Preece has garnered, Pennink remains in contention.
After consecutive finishes outside the top 10 at Riverhead Raceway and New Hampshire Motor Speedway in the fifth and sixth events on the schedule, Pennink slipped a season-high 44 tallies behind Preece – essentially a full race's worth of points. But a third-place finish last week at Monadnock Speedway stabilized the brief slide.
As the Whelen Modified Tour begins the schedule's second half in a return to Stafford Motor Speedway this week for the CARQUEST 150, Pennink will look to make ground on two fronts: in the points and in the win column.
A contender to win on most weeks, it has been 42 races since Pennink captured his first Whelen Modified Tour checkered flag at Riverhead during the 2010 season. As one of his best tracks, Stafford will provide the Huntingdon Valley, Pa., driver with a good opportunity to end the drought as well as gain on Preece.
In his last 11 starts at the Stafford half mile, Pennink has posted six top-fives, including a pair of runner-up finishes. In the first two Whelen Modified Tour races at Stafford this season he's finished fifth and third, respectively.
If he is able to accomplish either a win or a points gain – or both – this week, Pennink will have to beat Preece at a track where he already has seven total Modified wins this season. But if Pennink has showed us anything in the season's first half, it's that he's not yet ready to yield.


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Forget password?
Remember Me
Big Sam's Funky Nation is a driving force of urban funk. Ryan White, of the Oregonian, says the band is "tight enough (and hot enough) to turn coal into a diamond!" The band is led by trombone powerhouse, Big Sam Williams, formerly the trombonist for the Dirty Dozen Brass Band, who the San Francisco Chronicle calls "the top man on the slide trombone in the birthplace of jazz." Big Sam refuses to let the audience sit still. Between the band's solos, Big Sam's signature dance moves and his distinctive trombone riffs, the energy level is high...


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|Community structure of helminth parasites of the "Cururu" toad, Rhinella icterica (Anura: Bufonidae) from southern Brazil.
MedLine Citation:
|PMID: 23340719 Owner: NLM Status: Publisher
|Sixty specimens of the "cururu" toad, Rhinella icterica (Spix 1824) (Bufonidae), were collected in Campo Belo do Sul, State of Santa Catarina, Brazil, between May 2009 and January 2011, and were examined for the presence of helminth parasites. Nine species of adult helminths were found: Catadiscus cohni, Rudolphitrema rudolphii, Cylindrotaenia sp., Rhabdias fuelleborni, Strongyloides sp., Cosmocerca rara, Cosmocerca brasiliensis, Aplectana elenae, and Oxyascaris sp., in addition to an unidentified adult nematode species. Females of cosmocercid nematodes, proteocephalan plerocercoid, and acanthocephalan cystacanth were found but not identified for lack absolute of taxonomic characters. The sex of the anurans had no influence on prevalence, abundance, and richness of helminth species. Length and body mass of hosts did not influence the prevalence and richness of helminths, while the abundance of R. fuelleborni was significantly correlated with both parameters.
|Viviane Gularte Tavares Dos Santos; Suzana B Amato; Márcio Borges-Martins
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Publication Detail:
|Type: JOURNAL ARTICLE Date: 2013-1-23
Journal Detail:
|Title: Parasitology research Volume: - ISSN: 1432-1955 ISO Abbreviation: Parasitol. Res. Publication Date: 2013 Jan
Date Detail:
|Created Date: 2013-1-23 Completed Date: - Revised Date: -
Medline Journal Info:
|Nlm Unique ID: 8703571 Medline TA: Parasitol Res Country: -
Other Details:
|Languages: ENG Pagination: - Citation Subset: -
|Programa de Pós-Graduação em Biologia Animal, Departamento de Zoologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil, email@example.com.
Export Citation:
|APA/MLA Format Download EndNote Download BibTex
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Investec appoints Ben Smith head of Australian unitComment on this story
Johannesburg - Investec Plc, which owns a bank and money manager in South Africa and the UK, named Ben Smith as head of investment banking in Australia after Christian Nicks quit amid losses and job cuts.
Smith, a senior corporate adviser, has been with Investec since 2001 and was an executive with Wentworth Associates, Johannesburg- and London-based Investec said in an e-mailed statement today.
Nicks ran the investment bank for four years.
Investec cut 80 jobs and closed or scaled back its Australian securities, equity capital markets and structured financial products businesses in the six months through September after the bank's operations in the country reported a loss of A$12 million ($10.5 million).
In November, it appointed Ernst & Young, King & Wood Mallesons and Greenhill to review the potential sale of some Australian units.
There have been no developments since then, Ursula Nobrega, head of investor relations at Investec, said in an e-mailed response to questions today.
"The sale process is ongoing," she said.
"We have received interest from a number of parties."
Investec rose 2.3 percent to 73.03 rand, its biggest intraday move in a month, by 10:29 a.m. in Johannesburg trading. - Bloomberg News
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I work for a school news paper at West Senior High and we run adds if you would like to run a add for a novel or just simple your page we would be happy to publish it with in the newspaper and send a copy to you. If you are interest you can message me at email@example.com or firstname.lastname@example.com for more info and prices of add placements
We publish issues from the beginning of the school year which starts first week of september to normally around june 11th as of now since we are finishing up any adds with not be able to be put in until the beginning of the school year of 2013-2014.
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Mr. Chalmers died Wednesday, Dec. 26, 2012, at his residence.
Born March 23, 1967, in Monroe County, Mich., he was son of Christopher and Kathleen Chalmers of Brownstown, Mich.
Mr. Chalmers served his country proudly in the United States Marine Corps for more than seven years. He was decorated, having received the Good Conduct Medal, National Defense Service Medal, Southwest Asia Service Medal, Kuwait Liberation Medal, Navy Achievement Medal, Navy Unit Commendation, Joint Meritorious Unit Award, Sea Service Deployment Ribbon, Meritorious Mast, Letter of Appreciation and an Expert Rifle Badge.
Survivors include his loving wife, Porsha Ann Chalmers of Lula; son, Matthew Keith Chalmers of Lincoln Park, Mich.; sister, Christine Burget (Calvin) of Pinellas Park, Fla.; mother-in-law and father-in-law, Earl Sr. and Louise Nix of Gillsville; sisters-in-law, Jane Smith (Mike) of Alto and Elaine Williams (Jeff) of Cornelia; brother-in-law, Earl Jr. and Lisa Nix of Gillsville; 13 nieces and nephews.
The family will receive friends at the funeral home from 2-4 p.m. and 6-8 p.m. today, Dec. 28.
An online guest register is available and may be viewed at mcgaheegriffinandstewart.com.
McGahee-Griffin & Stewart Funeral Home, Cornelia, is in charge of arrangements.
The Northeast Georgian
December 28, 2012


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i have one!
it came with my 4x5 camera, i only tried with some e6 film, colors and contrast are quite pale against other modern lenses, to me it has the look of an older lens not a 10 years old one, i'm not an expert and i have just tried another 90mm lens, so take my advice as a pinch of salt.
in hand it looks cheap and small but if you travel with it that should be good thing, and it takes 40.5mm filters.
pd. it let me enough movements without vignetting, i haven't tried any extreme movements, but for normal stuff there´s plenty of room


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- SCU Home Page
- About SCU
- Admission
- Academics
- On Campus
- News & Info
- Alumni
SCU in the News
Mike Malone
Mike Malone (English) was included in a Metro article featuring new grads Gabrielle Jasinski, Eliza Lamson, Hannah Miller and Liz Wassmann for the first book published by SCU students, Moving Out.
Posted by Nic Domek
Here's a sampling of the hundreds of mentions of SCU in the media in the past two weeks. The first part of the link is a list; the full text is below the list.


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November 27, 2015
The College Station Police Department is preparing to conduct the 45th session of the Citizen Police Academy. This free ten-week program, slated to begin February 7, 2012, is designed to provide citizens with information on how the criminal justice system and police department operate, and how police and community residents can work together to reduce crime. A variety of methods, from hands on classroom instruction to role-playing, and accompanying officers on their actual patrol shift, will provide community residents with a good look at police operations from the inside.
Topics covered by police instructors and outside experts will include:
Criminal Law
Traffic Law
Criminal Investigations
Crime Scene Investigation
Uniformed Patrol
Communications (911 Dispatch)
Court System
S.W.A.T. / Negotiations
And Much More
Citizens interested in attending the Citizen Police Academy should complete an application. Applications are available at the College Station Police Department, 2611 Texas Avenue. You can also call 764-3573 to request an application by mail, email or fax. Citizens can also go to http://cstx.gov/cpa for information and to apply online. The deadline for applying is Friday, January 27th, at 5 p.m. Again, there is no charge for the academy course.
Each session will run from 6:30 p.m. to 9:30 p.m. every Tuesday night beginning February 7, 2012, and ending May 1, 2012. Sessions will be conducted at the Police Department. For more information, contact Officer Dennis Bain, Community Services Division, College Station Police Department, 764-3573 or firstname.lastname@example.com, or Lt. Craig Anderson at 764-3610 or firstname.lastname@example.com.
Click Here to access the online Public Inspection File
Viewers with disabilities can get assistance accessing this station's FCC Public Inspection File by contacting the station with the information listed below. Questions or concerns relating to the accessibility of the FCC's online public file system should be directed to the FCC at 888-225-5322, 888-835-5322 (TTY), or email@example.com.


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Update: Council committee OKs West Seattle Triangle rezoningNovember 30, 2011 at 10:40 am | In Development, Triangle, West Seattle news | 6 Comments
(This is now the archived video of today's meeting, time-coded to start when this agenda item began)
10:40 AM: Click the "play" button and you'll see the Seattle City Council's Committee on the Built Environment, talking about the West Seattle Triangle rezoning proposal for the second time this month. (The agenda includes links to the documents and maps they're discussing.) They may or may not vote today; they need to vote on it before it can go to the full council. Whatever decision is made by the city will affect the face of that section of West Seattle for decades to come – part of the area, including some lots around the Triangle edges, including the west side of Fauntleroy for a stretch south of SW Alaska, is proposed for upzoning to 85 feet. We'll note highlights and the meeting results, as this goes along. (The meeting started at 9 am, but the committee had another weighty item to get through first – a zoning change in the Roosevelt area of North Seattle – so they didnt get to the Triangle till 10:40 am.)
10:45 AM: They've just voted to amend the proposal to include 85-foot zoning on both sides of Fauntleroy for the stretch between Alaska and Edmunds. (See this "map amendment" here.)
10:56 AM: They've just approved some amendments, including extending the "pedestrian" zone to 35th, whereas previously it ended at 36th SW. As they get ready to vote on the entire bill, Councilmember Sally Bagshaw says not everyone is happy with everything, but it's a "give and take" process. Councilmember Tom Rasmussen, who's been involved in Triangle planning for more than three years, says he's excited, "while there are still some outstanding issues … and I don't think we're going to get back to that … the community was heard (relating to height issues, in that some areas will stay at 65-foot zoning)." He thanks the community for spending "a lot of time on this."
10:59 AM: The rezoning proposal passes the committee with a unanimous vote. The committee also has approved a resolution calling for SDOT to do a parking study in The Triangle as the result of issues that came up during the last leg of the planning process. Next step: This all goes to the full Council next month.
6 Comments
85-feet. 8 story buildings packed into the Triangle. Ridiculous. What a gift to the landowners and developers.
Comment by Herman — 12:01 pm December 1, 2011 #
West Seattle folk need to go and speak. Roosevelt had about a dozen speakers, while West Seattle had none. Is this our neighborhood, or the City's playground?
Comment by pjmanley — 11:34 pm December 1, 2011 #
Unfortunately we don't have anyone who can devote full-time attention to advocating against the city. This vote was typical and I'm sure the full council vote, if there is one, will be the same. If they want something, they will ram it through eventually even if neighbors yell their heads off.
Note the way they introduce "proposals" at these meetings as if they had nothing to do with it.
They scrupulously avoid any statement about who exactly proposed the 85 ft height and why the hell it was suggested in the first place.
Slimy weasels know all the tricks.
Comment by JoAnne — 9:21 am December 2, 2011 #
Which one do you want? Slightly tall buildings, or a housing supply thats too low, and therefore makes housing prices skyrocket.
I for one am all for the rezone.
Comment by Chetan — 2:25 pm December 8, 2011 #
I'm glad we will have more housing supply in the neighborhood! This rezone is a good thing for making the neighborhood more vibrant and allowing more people to live here and patronize restaurants, shops, etc.
Comment by pragmatic — 3:51 pm December 8, 2011 #
I'm all for the rezone as long as the city plans on approving funds for new gondola/subway/light rail lines… I'm pro-density with the proviso that we'll need real, grade-separated electric transit to meet West Seattle's needs.
Comment by Cascadianone — 4:13 pm December 9, 2011 #
Sorry, comment time is over.
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