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Antonio Pigafetta, a Florentine navigator who went with Magellan on the first voyage around the world, wrote, upon his passage through our southern lands of America, a strictly accurate account that nonetheless resembles a venture into fantasy. In it he recorded that he had seen hogs with navels on their haunches, clawless birds whose hens laid eggs on the backs of their mates, and others still, resembling tongueless pelicans, with beaks like spoons. He wrote of having seen a misbegotten creature with the head and ears of a mule, a camel's body, the legs of a deer and the whinny of a horse. He described how the first native encountered in Patagonia was confronted with a mirror, whereupon that impassioned giant lost his senses to the terror of his own image.
This short and fascinating book, which even then contained the seeds of our present-day novels, is by no means the most staggering account of our reality in that age. The Chronicles of the Indies left us countless others. Eldorado, our so avidly sought and illusory land, appeared on numerous maps for many a long year, shifting its place and form to suit the fantasy of cartographers. In his search for the fountain of eternal youth, the mythical Alvar Núñez Cabeza de Vaca explored the north of Mexico for eight years, in a deluded expedition whose members devoured each other and only five of whom returned, of the six hundred who had undertaken it. One of the many unfathomed mysteries of that age is that of the eleven thousand mules, each loaded with one hundred pounds of gold, that left Cuzco one day to pay the ransom of Atahualpa and never reached their destination. Subsequently, in colonial times, hens were sold in Cartagena de Indias, that had been raised on alluvial land and whose gizzards contained tiny lumps of gold. One founder's lust for gold beset us until recently. As late as the last century, a German mission appointed to study the construction of an interoceanic railroad across the Isthmus of Panama concluded that the project was feasible on one condition: that the rails not be made of iron, which was scarce in the region, but of gold.
Our independence from Spanish domination did not put us beyond the reach of madness. General Antonio López de Santana, three times dictator of Mexico, held a magnificent funeral for the right leg he had lost in the so-called Pastry War. General Gabriel García Moreno ruled Ecuador for sixteen years as an absolute monarch; at his wake, the corpse was seated on the presidential chair, decked out in full-dress uniform and a protective layer of medals. General Maximiliano Hernández Martínez, the theosophical despot of El Salvador who had thirty thousand peasants slaughtered in a savage massacre, invented a pendulum to detect poison in his food, and had streetlamps draped in red paper to defeat an epidemic of scarlet fever. The statue to General Francisco Moraz´n erected in the main square of Tegucigalpa is actually one of Marshal Ney, purchased at a Paris warehouse of second-hand sculptures.
Eleven years ago, the Chilean Pablo Neruda, one of the outstanding poets of our time, enlightened this audience with his word. Since then, the Europeans of good will—and sometimes those of bad, as well—have been struck, with ever greater force, by the unearthly tidings of Latin America, that boundless realm of haunted men and historic women, whose unending obstinacy blurs into legend. We have not had a moment's rest. A promethean president, entrenched in his burning palace, died fighting an entire army, alone; and two suspicious airplane accidents, yet to be explained, cut short the life of another great-hearted president and that of a democratic soldier who had revived the dignity of his people. There have been five wars and seventeen military coups; there emerged a diabolic dictator who is carrying out, in God's name, the first Latin American ethnocide of our time. In the meantime, twenty million Latin American children died before the age of one—more than have been born in Europe since 1970. Those missing because of repression number nearly one hundred and twenty thousand, which is as if no one could account for all the inhabitants of Uppsala. Numerous women arrested while pregnant have given birth in Argentine prisons, yet nobody knows the whereabouts and identity of their children who were furtively adopted or sent to an orphanage by order of the military authorities. Because they tried to change this state of things, nearly two hundred thousand men and women have died throughout the continent, and over one hundred thousand have lost their lives in three small and ill-fated countries of Central America: Nicaragua, El Salvador and Guatemala. If this had happened in the United States, the corresponding figure would be that of one million six hundred thousand violent deaths in four years.
One million people have fled Chile, a country with a tradition of hospitality—that is, ten per cent of its population. Uruguay, a tiny nation of two and a half million inhabitants which considered itself the continent's most civilized country, has lost to exile one out of every five citizens. Since 1979, the civil war in El Salvador has produced almost one refugee every twenty minutes. The country that could be formed of all the exiles and forced emigrants of Latin America would have a population larger than that of Norway.
I dare to think that it is this outsized reality, and not just its literary expression, that has deserved the attention of the Swedish Academy of Letters. A reality not of paper, but one that lives within us and determines each instant of our countless daily deaths, and that nourishes a source of insatiable creativity, full of sorrow and beauty, of which this roving and nostalgic Colombian is but one cipher more, singled out by fortune. Poets and beggars, musicians and prophets, warriors and scoundrels, all creatures of that unbridled reality, we have had to ask but little of imagination, for our crucial problem has been a lack of conventional means to render our lives believable. This, my friends, is the crux of our solitude.
And if these difficulties, whose essence we share, hinder us, it is understandable that the rational talents on this side of the world, exalted in the contemplation of their own cultures, should have found themselves without valid means to interpret us. It is only natural that they insist on measuring us with the yardstick that they use for themselves, forgetting that the ravages of life are not the same for all, and that the quest of our own identity is just as arduous and bloody for us as it was for them. The interpretation of our reality through patterns not our own, serves only to make us ever more unknown, ever less free, ever more solitary. Venerable Europe would perhaps be more perceptive if it tried to see us in its own past. If only it recalled that London took three hundred years to build its first city wall, and three hundred years more to acquire a bishop; that Rome laboured in a gloom of uncertainty for twenty centuries, until an Etruscan King anchored it in history; and that the peaceful Swiss of today, who feast us with their mild cheeses and apathetic watches, bloodied Europe as soldiers of fortune, as late as the Sixteenth Century. Even at the height of the Renaissance, twelve thousand lansquenets in the pay of the imperial armies sacked and devastated Rome and put eight thousand of its inhabitants to the sword.
I do not mean to embody the illusions of Tonio Kröger, whose dreams of uniting a chaste north to a passionate south were exalted here, fifty-three years ago, by Thomas Mann. But I do believe that those clear-sighted Europeans who struggle, here as well, for a more just and humane homeland, could help us far better if they reconsidered their way of seeing us. Solidarity with our dreams will not make us feel less alone, as long as it is not translated into concrete acts of legitimate support for all the peoples that assume the illusion of having a life of their own in the distribution of the world.
Latin America neither wants, nor has any reason, to be a pawn without a will of its own; nor is it merely wishful thinking that its quest for independence and originality should become a Western aspiration. However, the navigational advances that have narrowed such distances between our Americas and Europe seem, conversely, to have accentuated our cultural remoteness. Why is the originality so readily granted us in literature so mistrustfully denied us in our difficult attempts at social change? Why think that the social justice sought by progressive Europeans for their own countries cannot also be a goal for Latin America, with different methods for dissimilar conditions? No: the immeasurable violence and pain of our history are the result of age-old inequities and untold bitterness, and not a conspiracy plotted three thousand leagues from our home. But many European leaders and thinkers have thought so, with the childishness of old-timers who have forgotten the fruitful excess of their youth as if it were impossible to find another destiny than to live at the mercy of the two great masters of the world. This, my friends, is the very scale of our solitude.
In spite of this, to oppression, plundering and abandonment, we respond with life. Neither floods nor plagues, famines nor cataclysms, nor even the eternal wars of century upon century, have been able to subdue the persistent advantage of life over death. An advantage that grows and quickens: every year, there are seventy-four million more births than deaths, a sufficient number of new lives to multiply, each year, the population of New York sevenfold. Most of these births occur in the countries of least resources—including, of course, those of Latin America. Conversely, the most prosperous countries have succeeded in accumulating powers of destruction such as to annihilate, a hundred times over, not only all the human beings that have existed to this day, but also the totality of all living beings that have ever drawn breath on this planet of misfortune.
On a day like today, my master William Faulkner said, "I decline to accept the end of man". I would fall unworthy of standing in this place that was his, if I were not fully aware that the colossal tragedy he refused to recognize thirty-two years ago is now, for the first time since the beginning of humanity, nothing more than a simple scientific possibility. Faced with this awesome reality that must have seemed a mere utopia through all of human time, we, the inventors of tales, who will believe anything, feel entitled to believe that it is not yet too late to engage in the creation of the opposite utopia. A new and sweeping utopia of life, where no one will be able to decide for others how they die, where love will prove true and happiness be possible, and where the races condemned to one hundred years of solitude will have, at last and forever, a second opportunity on earth.
From Nobel Lectures, Literature 1981-1990, Editor-in-Charge Tore Frängsmyr, Editor Sture Allén, World Scientific Publishing Co., Singapore, 1993
Copyright © The Nobel Foundation 1982
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Part 1 of a 2-Part Series. For Part 2, click here.
With the prevalence of diagnosed and undiagnosed diabetes mellitus pegged at 8.3% in 2010 by the Centers for Disease Control and Prevention (CDC) (Figure), and evidence suggesting that medical therapy is suboptimal in a majority of patients, efforts to ensure that patients know how to best manage their disease are more critical than ever. And although educational programs to achieve this end are available, according to one assessment, only 55% of patients with diabetes have accessed these resources (http://apps.nccd.cdc.gov/DDTSTRS/default.aspx).
The magnitude of the public health challenge posed by diabetes is even greater in Alabama, where in 2010, Kristi Kelley, PharmD, helped to launch a pharmacist-run education program for patients with type 2 diabetes at Baptist Health Inc., in Birmingham. An estimated 11.7% of Alabama's citizens reportedly carried a diagnosis of diabetes in 2011 (http://apps.nccd.cdc.gov/DDTSTRS/default.aspx), she said.
When Dr. Kelley's team created a collaborative, individualized education program at two of Baptist Health's internal medicine resident clinics—the initial point of care for many of the health system's patients with diabetes—they wanted to ensure patients had access to the program (poster 85). "At least one-third of the patients in our internal medicine clinics are uninsured and from an underserved population, which had made it challenging to refer to the hospital's existing diabetes education programs, since they require payment," explained Dr. Kelley, a clinical pharmacist in the hospital's Continuity of Care Clinic and an associate clinical professor in the Department of Pharmacy Practice at Auburn University Harrison School of Pharmacy, in Auburn. Given the patient population, Dr. Kelley's team offered one-on-one sessions with a clinical or student pharmacist free of charge. A scarcity of resources meant the program had to be targeted for maximum efficacy, so she and her team asked clinic staff to refer only those patients who would most likely benefit from additional education.
During sessions, patients received printed literature, counseling and a demonstration insulin injection to ensure their technique was correct. Educational content was tailored to each patient's specific needs, with the most common topics being nutritional management and lifestyle modification, medication safety, ways of maximizing drug treatment efficacy, the role of blood glucose monitoring and the importance of preventing, detecting and treating acute disease complications. Some participants received more than one session if the pharmacist deemed it necessary or if the patient requested it.
According to Dr. Kelley, 27% (47 of 172) of the internal medicine clinics' patients with diabetes participated in at least one session during the 18-month study period following the program's implementation. Among the 25 participants with available pre- and postintervention laboratory data, average hemoglobin A1c (HbA1c) levels dropped from 9.4% prior to the intervention to 8.2% afterward.
Noting that a 1% reduction in HbA1c is associated with an approximately 40% reduction in the incidence of microvascular complications, Dr. Kelley emphasized that the results are clinically meaningful (Diabetes 1995;44:968-983).
She said the multidisciplinary aspect of the program was critical to its success. Access to patient medical records allowed the pharmacist to contact the treating physician and recommend dose adjustments. For individuals who could not afford prescribed medications, the pharmacist worked with a social worker or resident to help obtain medications that were within their budget.
Although the initiative was linked to improved patient outcomes, Dr. Kelley suggested that staff have limited time to devote to work that is not reimbursed. "In a different setting such as a private physician's office or a group practice, it potentially could be easier to bill," she said.
Community Outreach
In Burlington, N.C., Rachel Selinger, PharmD, a clinical pharmacy specialist at the University of North Carolina at Chapel Hill's Campus Health Services, and her colleagues ran a diabetes patient education program in a community health clinic setting (poster 37).
The initiative, which was implemented at the Charles Drew Community Health Center, where Dr. Selinger was the pharmacy manager at the time of the intervention, was part of the Patient Safety and Clinical Pharmacy Services Collaborative, a government-funded program aimed at improving outcomes and reducing adverse drug events (http://www.hrsa.gov/publichealth/clinical/patientsafety/index.html). Like the Alabama program, it also targeted higher-risk patients—specifically, those with little clinic contact and HbA1c levels above 9%. About 95% of the patients seen had type 2 diabetes, Dr. Selinger noted.
Between September 2010 and August 2011, a case manager contacted 30 of these patients by phone and explained that their disease was not under control and that they were at risk for developing related complications. Those patients who were interested in better managing their disease subsequently met with a clinical pharmacist who reviewed optimal medication management strategies, provided medication adherence counseling and overall disease education, and worked with the patient's physician or nurse practitioner to make dose adjustments if necessary.
Molly Howard, a PharmD candidate at Creighton University's School of Pharmacy and Health Professions, in Omaha, Neb., and an intern at the Charles Drew Community Health Center when the program took place, presented the initiative's outcomes at the ACCP Symposium. She said that after an average of three to four sessions, each lasting 15 to 30 minutes, HbA1c levels fell below 9% in roughly 40% of the participants.
However, like the Auburn program, the N.C. initiative also came up against logistical and financial hurdles. "The time and resources required for programs like ours are difficult to sustain, with employees taking on additional tasks and with no organizational profit to warrant additional staffing," Dr. Howard explained. "That being said, when the resources are available, these initiatives ultimately decrease the workload for physicians, improve outcomes and lower the overall cost to our health care system."
Indeed, the CDC has reported the benefits of various preventive care strategies in diabetes (Table).
Strength in Numbers
A group-based approach outlined by Brittany Cogdill, PharmD, a clinical pharmacy specialist in ambulatory care at the Medical University of South Carolina's College of Pharmacy, in Charleston, may be less time-intensive than individual education (abstract 8). Furthermore, it offers other unique advantages.
"Group members benefit from receiving advice from others with diabetes, particularly when it comes to diet, instead of listening to health care professionals tell them what they should do," Dr. Cogdill said in an interview, noting that 85% of participants in a group program she and her colleagues implemented preferred this format over an individual approach.
The program was offered free of charge to patients referred from the university's affiliated hospital outpatient family medicine clinic. Individuals were initially contacted by phone by a pharmacist and invited to attend four 2.5-hour educational sessions—a total of 10 hours over a one-year period, she noted.
Dr. Cogdill structured the group discussions on the American Diabetes Association's Diabetes Conversation Maps (http://www.healthyinteractions.com/conversation-map-programs/conversation-map-experience/current-programs/usdiabetes), which provide talking points around nutritional management, insulin treatment and blood glucose monitoring as well as information on the natural course of the disease, potential complications and gestational diabetes.
Thirty-two patients with type 2 diabetes attended a single class and nine returned for more than one session over a one-year period. The intervention proved effective as evidenced by decreases in HbA1c. Among those with available laboratory data, average HbA1c dropped from 9.4% to 8.3% after group participation. Furthermore, systolic and diastolic blood pressure as well as low-density lipoprotein levels also decreased. Although the changes were not statistically significant, "the numbers "trended toward improved patient outcomes," Dr. Cogdill said.
The program did not involve a drug management component, but some patients may have had medication adjustments under their physicians' care—a factor that Dr. Cogdill's team did not account for when analyzing their outcomes.
Kudos on Effort, But Study Design Criticized
Pharmacist-run programs will only be reimbursed if studies like these continue to be conducted, according to Brian Irons, PharmD, the division head of ambulatory care and an associate professor in the Department of Pharmacy Practice at the Texas Tech University Health Sciences Center's School of Pharmacy, in Lubbock.
"We know we can provide high-quality patient education and drug therapy management, and we need more demonstration projects like these to show other providers what we can bring to the table," said Dr. Irons, who has previously developed and studied pharmacist-led educational programs but was not involved in the studies.
Although the studies are encouraging, the conclusions are hampered by several significant design weaknesses, he said, and stronger studies on the topic need to be conducted. "The number of patients in each of the abstracts is small, there were no control groups, and there are many possible confounding variables that are difficult to account for," he said. "Therefore, it's not clear precisely to what extent the interventions and the pharmacist's involvement actually contributed to improved outcomes and HbA1c reductions."
Drs. Irons, Cogdill and Kelley and Ms. Howard reported no relevant financial conflicts of interest.
More than one-third of diabetes patients do not take their insulin as prescribed1 and one-fifth intentionally skip doses.2 Pharmacists can help address the issue of poor insulin adherence in two ways:
Recommending shorter needles also might improve injection site rotation, which about half of diabetes patients report not doing frequently enough,3 and which can cause lipohypertrophy and significantly affect insulin absorption.4 Longer needles require that patients pinch up skin and use two hands, whereas shorter needles can be injected with one hand and injection sites can be accessed more easily. Longer needles also may enter into the muscle, where insulin injection can lead to hypoglycemia.
Many pharmacists would say they do not have the time to schedule appointments and provide one-on-one education, but tasks like checking blood glucose, running a lipid panel or weighing the patient before they meet with the pharmacist, can be delegated to a technician in many cases, leaving the pharmacist with more time to review training and results.
Taking the few extra minutes to check a patient's treatment routine and ensure appropriate protocols are being followed can improve outcomes and position the pharmacy as a recognized center for diabetes care.

subset: commoncrawl


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Real Help For Urinary Infections
Tips for Natural Prevention and Treatment of Urinary Tract Infections (UTIs)
Can Baking Soda Help Relieve a Urinary Tract Infection?
However, don't be discouraged, because here is a cheap and effective remedy-- just be sure to start doing this at the first hint of an impending urinary tract infection. If you want to know more about how Baking Soda works, read Dr. Young's popular book The pH Miracle: Balance Your Diet, Reclaim Your Health (see it on the sidebar). If you have high blood pressure or other serious health issues, consult your physician before taking in any baking soda.
Put 1/4 teaspoon of common, ordinary Baking Soda into an 8-ounce glass of water. Stir it up. Drink it while it fizzes once a day beginning when you feel a urinary tract infection coming on. Drink for no longer than 2 weeks.
References in this blog are meant for information only and if you have a condition of concern, please consult with your trusted health care provider.
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NXP has released its first single-channel common-mode filter with integrated ESD protection up to 15 kV contact discharge in a 0.4 mm pitch wafer-level chip-size package (WLCSP6). IP3319CX6 protects sensitive I/Os as USB 2.0, digital video interface and low-voltage differential signalling interfaces from destruction by ESD. The device eliminates common-mode noise from high-speed interfaces with differential data and attenuates common-mode noise of 800 MHz. Differential-mode signal extends out to more than 1 GHz before reaching the -3 dB point. IP3319CX6 integrates two ultra-low capacitance rail-to-rail diodes plus a separate protection diode, which enables the protection to work independently from availability of a supply voltage.
Download datasheets
Key features and benefits
- Very wide differential pass band > 1 GHz
- Very broadband common-mode attenuation
- 2-lines (one differential channel) common-mode filter
- ESD protection for the USB ID line
- Extremely low clamping ESD protection, excellent SoC protection
- ESD protection up to +/- 15 kV on external contact pins
- Ultra low ESD diode capacitance
- Very small WLCSP6 package (1.6 x 1.15 x 0.65) with 0.4 mm pitch
Key applications
- Mobile phones
- USB 2.0 high-speed lines
- Low-voltage differential signaling (LVDS) interfaces
- Digital video interfaces (DVI)


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So getting the latest chassis from Suter is a reason to dislike the guy? Who should they give it to, the guy who is 3 seconds off the pace? This sport is all about combining the best technology with the best technique, its strange how many posters here are struggling to understand the concept.


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In case you missed it, here are highlights of the top stories from the weekend.
Sunday, Jan. 6
Mentoring's ripple effect: School-based programs offer new avenue for youths in need
Allie Clarke and Tori Cordova have a friendship built on love, trust and respect.
- Jan. 5, 2013
Grant Family Farms closes, files for bankruptcy
After 61 years of farming, Grant Family Farms has closed and filed for bankruptcy, citing crop damage and financial hardships.
- Jan. 5, 2013
Suicides, vehicle crashes lead non-natural deaths in Larimer County in 2012
Most Larimer County residents die of natural causes. In fact, more than 90 percent of deaths reported in the county in 2011 were determined to be natural.
- Jan. 5, 2013
Like father like sons: Sonny Lubick's sons follow in dad's footsteps
Family is one of the few passions greater than coaching football for Sonny Lubick, which made the moves from coast to coast his family endured during his coaching career difficult.
- Jan. 6, 2013
Saturday, Jan. 5
Longtime Old Town Fort Collins Mexican restaurant closes
Yet another Old Town Fort Collins restaurant has closed, leaving vacant a prime location with ample parking.
- Jan. 4, 2013
Larimer County postpones decision on Roberts Ranch gift
The Larimer County Open Lands Advisory Board has postponed its vote on whether the county should accept a gift of the 16,500-acre Roberts Ranch near Livermore.
- Jan. 4, 2013
Fort Collins experts share resolution solutions
Just reading the next paragraph is enough to get most people's hearts racing.
- Jan. 4, 2013
CSU races past South Dakota Mines in women's basketball
Passes were crisp and shots were falling.
- Jan. 4, 2013


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Dr. Sensiba joined University Orthopedics Center (UOC) in August of 2010 and sees patients in need of orthopedic care at our State College office location on Regent Court. He is a fellowship trained orthopedic surgeon specializing in sports medicine. Dr. Sensiba completed his Sports Medicine Fellowship at Allegheny General Hospital, Pittsburgh, PA in July of 2010. His training and experience include unique competencies in the treatment of sports injuries, cartilage restoration, total joint replacement and minimally invasive surgery including arthroscopy of the shoulder, knee, elbow and ankle.
After receiving his Medical Degree from The Ohio State University, Columbus, Ohio in 2004, Dr. Sensiba completed his residency at the Department of Orthopedic Surgery, Wright State University, Dayton, Ohio.
Dr. Sensiba is a member of the American Academy of Orthopaedic Surgeons and American Medical Association.
Dr. Sensiba resides in State College, PA with his wife Branyan. They enjoy traveling and sports.
Dr. Sensiba is currently accepting new patients at our State College office. For an appointment please call at 814-231-2101 or 1-800-505-2101.
Honors and Awards:
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Reviewed By Stanley H J (Valrico, FL) Reviewed for a 2015 Ford Mustang —8/8/2015 1:22 AM
Took a while to receive but it was worth the wait. I ordered the smoke color for my black Mustang and it looks perfect and fit is great. Great price and free shipping is good also.


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TimesJobs Job SearchAdd to My Apps
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India's No 1 Job Portal.Access the Best Industry Jobs in INDIA - anywhere, anytime and while on the move!TimesJobs Android App makes it easy to keep up to date with the latest job opportunities.Features- Search and Apply for Jobs- Get Recommened Jobs for your profile right your Android phone- Everytime you apply for a job it gets sync'd to your TimesJobs account- For a new user, we show Jobs by Industry on home page for a faster job browsing experience- Added an Advance Search page for more refined search- Users can Manage their complete profile from the app itself, enabling them to keep profile updated and get better jobs- Users can Save Searches & Jobs and also get the list of applied jobs from server. These all are accessible from the Menu page- Integrated Inbox. This is one place where you get all the information about happenings in your account and activity. Events like recruiter contacts, job apply actions, career services updates etc, all come in once place for you. - Added support of MENU option for ICS based devices in which the hard menu button has been removed.We shall keep adding new features to the application which make your job search more productive and less time consuming.Please send your feedbacks and feature requests for our app to email@example.com with subject line as 'Android App'.


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How about a nation made up of ocean going cities?
Home › Forums › Community › Dreaming / Crazy Ideas / Speculation › How about a nation made up of ocean going cities?
This topic contains 25 replies, has 3 voices, and was last updated by William Holz 1 year, 6 months ago.
May 4, 2014 at 11:06 am #23417
First of all. . . you guys are awesome.
A few of us have been working on something different. . . more of a 'create a nation inside a corporation' thing, but one that was designed to embrace the variety of humanity rather than choose one specific governmental/economic system and expect everyone to agree. . . we want to break the birth nation lottery and give people the chance to choose better lives for themselves and raise the collective bar on civilization.
I think our biggish ideas converge beautifully into something even better.
I myself don't have an ego or care about credit, but I've got a moral obligation to at least try to get this concept into better hands than my own and I'm hoping maybe there are people here who may be able to help or just take it and run with it (I'd love to come along for the ride though!)
I don't have the visual design/artistic skills you guys have but I've managed to tighten the idea up with a little string of articles (easier to read than massive walls of text).
I didn't really have this in a form where I could communicate it well until recently . . . but I believe this contains the engine to create a LOT of floating cities (and other experiments) very, very quickly.
My amazingly archaic staging area is at . . . http://www.abiggishidea.com
If anybody wants to help, or can even find some good ideas in there they can acquire and repurpose then it'd definitely warm my heart. . . and similarly I'm very eager to help and I like to think I have a lot to bring the table.
-WillMay 4, 2014 at 11:09 am #23418
Also, for a more complete explanation . . . we submitted for the Buckminster Fuller prize (Mostly to connect with people) and their submission form did an excellent job of asking questions and I think it resulted in a pretty coherent explanation of the nonevil master plan!
Buckminster Fuller Submission
Visionary – put forth an original idea or synthesize existing ideas into a new strategy that creatively addresses a critical need
Comprehensive – apply a whole-systems approach to the design and implementation process and aim to address multiple goals, requirements and conditions in a holistic way
Anticipatory – factor in critical future trends and needs as well as the projected impacts of implementation in the short and long term
Ecologically Responsible – enhance the ability of natural systems to regenerate
Feasible – rely on current technology, existing resources and a solid team capable of implementing the project
Verifiable – able to demonstrate authentic claims backed by empirical data
Replicable – able to be adapted to similar conditions elsewhere
——Note: More details at abiggishidea.com——
What is your solution or strategy? – Provide a 50-word summary of your initiative.
We seek to create the seed of a corporation designed to allow gentle people to actively take over all aspects of their lives as creatively as possible in groups as small as 42 in exchange for helping us expand until we can invite everybody to join the civilization within.
What is the context? (200 words) – Describe the critical need(s) or specific systemic problem(s) your initiative seeks to address on the local and/or global levels.
Currently there are a large number of people who would choose to live peaceful, productive lives if they had the opportunity to do so. We are fully capable of maintaining a very high standard of living for these people and a large number of others.
In the world as it is now, a person's birth circumstance often determines a number of factors in a person's life, such as governmental system, ability to be a minority without being murdered, and likelihood of death by diarrhea.
This system is inefficient, as passions and motivations can be distributed wildly within a given population, while compromise solutions are inevitably 'races to the average' that do not properly embrace the sheer variety that exists within humanity as well as within each of us individually as we progress in time.
In addition, people generally do not have the power to make the following as opt-in choices:
Representation by officials who use freedom of speech as freedom to deceive
Being stalked or trolled
Being discriminated against
This also has the unfortunate side effect of a tragic lack of amazing toys, and of joy.
What/Where/How? (200 words) – Provide a detailed explanation of your initiative. What is it? Where is it based? How does it work?
The design has two major units: Peoplespheres and Worldminers.
Both groups are held to a basic set of principles (four!) that set a standard that's easy to achieve and results in people that are good to each other and create a positive working and living environment as well as to represent us well in the world at large. Characters such as Kaylee and Wash from the television series Firefly are good examples of our goal.
Peoplespheres are self-governing groups containing 42 people or more that agree on a method of conflict resolution, economy, living situation, and so on. They are focused on a specific task that either enhances the lives of those within or generates a revenue stream that allows us to expand. They are otherwise given as much control over their lives as is feasible.
Worldminers are the interface with the 'real' world, and they are encouraged to find every reasonable opportunity to obtain resources and create as many Peoplespheres as is possible.
Eventually hundreds of different Peoplespheres (or many more) will allow all people everywhere the option to choose between a large number of heavily customized, awesome lives.
Impact (200 words) – Who or what is impacted directly and indirectly by your initiative? Explain in detail how you measure and calculate impact.
We're creating a new collection of civilizations networked within our most powerful legal construct that uses "employment" to grant people the freedom to choose between them in exchange for useful work and peaceful coexistence. That's going to be hard to compete with and we expect to at least raise the collective bar a notch.
The only things that are up in the air are what order we do things in and how long this takes.
That makes it difficult to summarize impact in 200 words, but we are comfortable addressing the impact along a number of various implementation timelines.
Long-Term Effect (200 words) – What long-term systemic effects do you anticipate when your initiative is fully implemented?
The initial benefit is for the target employee/citizen/owners, though we fully expect to share some great art and technology with the world at large.
For a number of reasons, our focus on rapid expansion and self-governance may occasionally ruffle feathers and at some point we'd expect to have a disruptive impact. We anticipate making job offers to every human on the planet and right now the competition is Wal-Mart, unemployment, and war. The fact that corporations are abusively powerful makes some things easier, but it isn't humanity's most popular invention.
With that in mind, there's been a lot of focus in the design on alleviating that negative impact while maximizing the positive. Another role of the Worldminers will be to look for opportunities to positively impact local communities, and they'll be focused heavily on roles that benefit local comunities (healthcare, education, etc.).
We also plan to use our Peoplespheres to greatly reduce our environmental impact while researching ecologically positive policies and be as forward thinking as possible in our research and development, we expect that even having us as an option for children will provide a lot of hope in places where there was none before.
History and Vision (200 words) – What inspired your solution and how has the initiative evolved from inception to its current stage of development? How does your initiative creatively and comprehensively integrate the key social, cultural, economic, ecological, and technological factors required to transform "business as usual" in your chosen area of impact?
It was in part inspired by the enthusiasm generated by Valve's leaked employee handbook.
The initial plan was to create a small Valve-like company focused on healthcare data analytics and software tools using 3-D game tools and methodologies and to use the extra money to let the employees modify the office to help them work better as well as to make it useful/fun for them outside of business hours as well as to help people in need.
The thought of using the corporation to let good people take over their own lives was a logical step, and from there things scaled up.
As saving the world is a pretty popular but hasn't happened yet, we sought out roads less traveled. The design evolved into something closer to a framework that can contain a number of dreams/experiments and when possible we tried to identify with at least three options for people to choose from instead of selecting a specific one ourselves.
Also, humbly knowing that a small number of us are unlikely to have the best idea ever, it's also designed to replace itself if and when we succeed.
Planning and Operations (200 words) – Outline your implementation plan. What operational milestones do you intend to achieve in the next one to three years? What are the biggest risk factors or potential barriers facing the development and deployment of your initiative and how do you plan to mitigate them? How has your initiative been funded to date and how do you plan to ensure its financial viability?
The plan is to create a group of Worldminers and use them to start spawning off groups of Peoplespheres as quickly as possible.
Once we reach the point where each person we add provides a net positive benefit, we want to ramp that expansion up. We think that the principles we've defined at least set the low bar for an environment where people can get along and work well together, and we think that makes us particularly appealing for the sort of person we'd be looking for.
Eventually we hope to utilize the sheer power of our corporation to employ orphans, refugees, the unemployed, the caretakers and healers, the artists, and many more into peaceful, awesome citizenship
We hope to eventually have a multitude of options for everyone. . . from billionaires to hackers to hippies to whoever's reading this.
We have a small number of ideas and inventions that might help along the way, but the real hope is that by way of this process we get this idea into the hands of more people so that it can absorb their ideas and continue to improve organically.
This project is currently unfunded.
Compare and Contrast (200 words) – Compare and contrast your initiative with at least two other current projects or groups working to address the same critical need. Why is your proposal more likely to effect change and make a distinguishing impact compared to similar efforts?
The Venus Project: TVP was actually part of the early collection of ideas that inspired this, and part of the initial design was to create a way for TVP to gather people and resources quickly. We still find their efforts to be inspiring and we're all big fans.
We could be described as a place for many Venus Projects to live side by side with other dreams that are better for other people along with an engine for growth and an easy way for people to join the fun in the broken world we live in now.
United States of America: As an attempt to create a representative government, it's clear there was a lot of thought put into our home nation's design. We applaud the effort that went into prototyping a system that can really be run by the people.
We could be described as a place for many America-like experiments to reside without the need for a military and without having to include people who aren't fundamentally on the same page.
The Team (200 words) – Provide details regarding your current team and any plans to expand it in the future. You may include details about organizational/institutional partners committed to the success of your initiative and describe your team members' experience and qualifications as they relate to their ability to implement your initiative. If applicable, include information about any significant external validation, support, or funding your initiative has received to date.
The initiative was created and has been led by William Holz. Amanda Werhane has been a key part of the project since inception and Cody Campbell was heavily involved in the crucial early stages of the design. We are eagerly looking to expand that group.
In addition we'd like to thank the following for sharing their wonderful selves with us. This idea wouldn't exist without: Ze Frank, David Attenborough, Russell Brand, Susan Cain, Fred Rogers, Buckminster Fuller, Dan Pink, Ellen Degeneres, David Wong, Matthew Inman, Tali Sharot, Zach Weiner, Joss Whedon, Bai Fang Li, Kelvin Doe, Brene Brown, Hans Rosling, Jane McGonigal, Neil Degrasse Tyson, Bettie Page, Camillo Olivetti, Cory Doctorow, Adam Savage, Neal Stephenson, Bartolome de las Casas, Elizabeth Gilbert, Michael Dickinson, Douglas Adams, Stephen Hawking, August Landmesser, Steve Keen, Dan Ariely, George Takei, Rachel Maddow, Randall Munroe, Richard Feynman, and others too numerous to name.
And last, but certainly not least. . . we'd like to thank Rebecca Joy Holz for providing more influence, inspiration, and ideas to this project than the rest of us combined despite having left this world long before it began.May 4, 2014 at 9:06 pm #23420
Lots of reading there and in the linked web pages. Twenty years ago, i'd have believed it all.
I wrote a couple paragraphs here, but deleted them, figuring you aren't interested in why i say what you propose won't work for me, and won't work in the usa. But good luck, i won't be applying.May 5, 2014 at 7:25 am #23424
Actually, as much as this idea can work in the USA . . . it's far more powerful in the hands of people in the third world. We westerners would have a tremendously difficult time competing with orphans and refugees because the real lynchpin is motivation and a willingness to live peacefully and responsibly.
That being said, here in the States we're competing with unemployment and Wal-mart, and Americans are people too. I can't ignore them any more than I can ignore people in Bangladesh or North Korea, can I? They're all people.
I'm really interested in any useful criticisms because when it comes to communicating this a good bit of the work is figuring out what to leave out. Even at a few short (and somewhat amusing) articles I'm running into far too many people who are rejecting the idea based on some early impression of what it is that bears very little resemblance to what I'm trying to communicate here.
I can say with confidence that nothing like this has been given a chance and I'm more than happy to address any perceived flaws. I've done my due diligence.
I'd have really preferred your reasoning to 'I'm pretty sure I don't like because of things I'm not going to tell you' . . . but that's just because I want to do a better job communicating . . . it's an idea that requires people to want to join so you wouldn't be asked to participate if you were uninterested in what it actually is.May 5, 2014 at 11:24 am #23426
Ok, since you asked: There's too much cliquishness and xenophobia. I face it every moment i am among humans. Any difference, actual or imaginary, is a reason put forth for not getting along. There is a well defined class structure in the usa, and it cannot be broken.
I am told i cannot think, i cannot write, i cannot legally have a checking account, i cannot drive, i cannot physically pick up a loaf of bread, and god will send me to hell for owning a pickup truck. I am told i don't know where i am, i am told if i think i don't need help moving from point A to point B that i am psychotic. If i ask someone out (which i stopped doing 20+ years ago), i am told by that person that they are not a caretaker. If i call a place of business to ask if they are wheelchair accessable, they hang up on me. And the district attorney's office here has decided i cannot have trash pickup, have a flush toilet or shower in my house, because the neighbor's dogs will bark, causing them to bark is mental cruelty to animals, a 10 year felony charge. Another charming tidbit from the DA's office: i cannot put a $10 video camera inside my mailbox (it's 300ft away from the house, but on my property) to see if the mail was picked up or delivered, because it would violate the right to privacy of the neighbor's dogs…. inside my conventional steel mailbox with it's closed door 3ft off the ground on my property. There are many "companies" that do lawn care around here, but none will mow my lawn, one told me to go get married, then have my husband give them a call. The reason i bought land and built a house on it: no one would rent to me. The only reason i was able to buy the land: the seller "knew" i'd default and they'd get the land back. A personnel manager told me he could not hire me because employees came to his office en masse to say they'd quit if i was hired because they believed i wear dirty diapers, and altho i don't wear diapers, and don't need to, and don't want to, my words mean nothing.
So i am not interested in forming a new hell-hole with humans, i am interested in getting away from them. And no matter how highly you tout your new business model, you aren't going to fire anyone for treating me like i am brain dead or need full-time care. There's no words to quell bigotry, there's no physical proof sufficient to offset deeply held beliefs. And there's too many of them to re-educate them, they are opposed to education, and it's not my job. Humans in "3rd world countries" may have motivation to cooperate towards improving each other's lives, but that isn't true in the usa, where it's popular sport to tear each other down. Yep, i lumped them all together.May 5, 2014 at 11:34 am #23427
Maybe there is something wrong w/you, Kat,…:)May 5, 2014 at 11:44 am #23428
Hmmmm. . .
This whole idea is specifically for people who want to work together to create better lives and are enthusiastic about the same, but who don't want to just splinter away into tiny little groups that don't invite anybody else to play.
Also, we're kind of focused on people who are willing to give others chances and not hold grudges or lump people together . . . I figure there are somewhere between a few hundred million and a few billion of us, so no need to expand or reach until we've run out of prime candidates.
So given what you've said . . . you are absolutely correct and I can see why you (and you specifically) wouldn't be interested. I'm surprised you replied at all the first time, but now I do understand why you didn't go with your objections the first time around.
That being said, while I of course can't expect you to have read through everything and verified whether or not your points are addressed (that would be a foolish thing to expect, just as it would be foolish of somebody to expect me to re-read 'Atlas Shrugged' (once was more than enough . . .glah!)), I do have to point out that some of the points you bring up aren't relevant to this approach for a multitude of reasons.
I'm not saying it to convert you, of course . . . but I'm making sure it's out there so that nobody mistakenly thinks that your objections would apply to them or anybody else. I want to make sure this idea lives and grows on it's own merits.
So . . . is there anybody out there who'd be interested in working together? Given the mission statement I assume that there are quite a few who'd be excellent fits and might be able to take this idea far further than I can.May 5, 2014 at 11:49 am #23429
Maybe there is something wrong w/you, Kat,…:)
To be fair to Kat, I'm pretty sure we're all broken toys. I know I am and have a long way to go before I'm as wise as I as when I was six.May 5, 2014 at 11:51 am #23430
Ocean, of course there is something wrong with me. Everyone else is correct in everything they do and say and believe. I am the only one different, and i must be disposed of.May 5, 2014 at 8:58 pm #23434
Kat, I was just joking.
If there is anything you need, please don't hesitate to ask. I don't know where you live, but my opinion is that you should burn all your bridges behind you and get out of where you are right now and never look back.
Will, it seems to me that your idea (which seems a bit confusing and undefined at times) can only be achieved through seasteading, which seems to be an endeavor a bit confusing and undefined most of the times.May 5, 2014 at 9:20 pm #23436
That's actually why I'm here, Ocean. . . err . . . Mr. Opolis?
When it comes to actually solving problems and identifying solutions that actually work . . . that's my thing. But even working on far simpler projects in my old corporate life I'd run into situations where it was far easier to just prototype something and show people than explain it.
I've spent at least an order of magnitude of time trying to get this in a form that's easy to digest. I KNOW that by definition any sort of whole life solution is going to be complicated, but the part where you explain things to people . . . that's way outside my comfort level and just not how my brain works.
And this is WAY too big for me to prototype.
That's part of why I'm here. There aren't any issues I can't address or questions I can't answer that I'm aware of (and I've been at this for a while), but I'm not a marketing or communication type and none of us can be good at everything, right? Nobody's an island and I need help from people who can do the things I can't, and in return I can give you guys an ENGINE . . . a way to collect people far and wide and protect and nurture them while you expand almost as fast as you can find interested parties.
It's really not that complicated and I have a feeling that there are thousands of people like me who've seen what I'm trying to describe and most of them probably die or give up long before they can get anybody else to get it. Trying to get this into better hands has been positively nightmarish and exasperating. I know part of it's my fault because I'm struggling to figure out what to say in what order, but I think this idea has enough potential and work behind it that it deserves more people helping it. People like you guys.
I guess I am kind of begging for help, but it's not for personal reasons . . . it's because I'm frustrated by my own weaknesses when it comes to communicating something that I'm convinced is both important and will be obvious in retrospect. . . and I hope I've at least managed to demonstrate enough foresight and exposed my thought process enough to get a little aid. It's for the greater good after all.
And if I'm right (and I am) then we'll not just be taking about a few Seasteds in a dozen years but hundreds of Seasteads and similarly motivated land-based experiments in a fraction of the time.May 6, 2014 at 9:58 am #23444
Oh! And any details would be HUGELY appreciated, Ocean!
I promise you I'm one of the least confused people you'll ever meet, so if I can get any details on anything you think was missing or think might not work it would be really helpful. I can't address those with the information I've been given thus far.May 6, 2014 at 3:47 pm #23452
Well, my first observation so far is that your project has a very broad spectrum. To me, it seems almost impossible that you, and you alone can micro manage all of it (therefore, the feeling that "…this is WAY too big for me to prototype").
You will have to either narrow the scope of it or,…delegate? Also, as I said before, it is a bit confusing what your desired final product is, how you plan to achieve it, and what kind of involvement is required from the people who would be interested in your project.May 6, 2014 at 4:03 pm #23453
Hmm . . . this is still a little vague to work with, but it's actually a pretty good step.
Let's start smaller. Have you read the articles linked over at abiggishidea.com ? It's only perhaps 20 pages or so, and I put a lot of work into giving them a little flavor.
I say that because there's nothing for me to delegate and I'm largely unimportant in the grand scheme of things. By design this requires LESS Micromanagement than any other modernized system that I'm aware of.
That's actually part of why I use Valve and Mondragon as examples in the second article (MondraGoogleValve), because between the two of them they have good positive demonstrations of how a corporation can provide support for a person's entire life and local community in a positive way (Mondragon) and how people can be useful and productive in a modern context without micromanagement (Valve, I choose them specifically because of their success at the same in a standards-based environment).
As for desired final product, it's a huge virtual nation that connects and supports what you'd probably describe as tiny little micronations but uses the legal shell of a corporation to allow them to embrace humanity's variety and allow us to travel freely between experiments.
Keep 'em coming! This is the part I need help with . . . getting solutions out there until this clicks with people.
Would this be easier if I finished the Dr. Who story? I've got the last few bits in draft format and was just waiting on a good writing moment to tie it all together properly (I'm having them take over a TED talk at the end bit, so I'll be putting a lot of extra supporting information in the last chapter)May 6, 2014 at 4:35 pm #23455
This land-based micronation thing is why i bit down so hard on the Fonseca project starting on a boat with people who had never met each other or worked together on managing anything. There's plenty of land-based cities that pick and choose which laws to persecute their citizens with, and which perks to allow to who. You want 30 people to work together in a concrete bathtub out on the water, then shouldn't they first work together on land, where it's cheaper to come and go and supply and make mistakes? Among "the pilgrims", the Mormons, the Jonestown folks, and many others around the world, some worked, some didn't, but i see no study of them on this site. Ergo, i am very leery of a TSI project like this working, i'll go it alone.
But i am the absolute last person to manage humans, especially when there's sharks so near in the water. I was hoping to be with the very small group to prototype and prove what floats best, in an incubator situation.
I have had a job or two where people were very equal, and cooperative, and life was enjoyable. Then there was the opposite. I know what William is talking about is possible, but the odds are stacked against it.
The forum 'Dreaming / Crazy Ideas / Speculation' is closed to new topics and replies.
Posted on at


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by Amory Ross
Volvo Ocean Race, Day 4 of Leg 5. Amory Ross, MCM for Puma Ocean Racing powered by Berg, reports on the crew's progress:
Tom Addis observes Southern Ocean life on deck from the comfort and warmth of the hatch. PUMA Ocean Racing powered by BERG during leg 5 of the Volvo Ocean Race 2011-12
It feels a bit like the last supper; the table has been set and we're waiting for the wind to arrive.
Everyone's going about life today with a general casualness, trying to enjoy each waning moment of calm before the weather changes for the worse. In the back of our heads we're mindful of the forecast and the tough conditions ahead – 40 to 50 knots are very possible – but it's far from evident in the onboard mood. Smiles, laughs, and tales of previous Southern Ocean sufferings are abundant, even in the now-chilly climate.
It's not that anyone's ignorant or lazy, rather we've already made every preparation we possibly can and it's more a matter of staying relaxed. Mental strength carries twice the value of physical strength in this foreign world, and one thing we learned leaving Auckland, one thing we learned the hard way, was that if we weren't mentally prepared for what was coming, our bodies were useless. We're keen to avoid the same mistake this time, and so we've been taking care of the little things over the last few days in order to enjoy today's final hours of relative peace.
Neck and wrist seals on our survival suits have been trimmed, valuables are stowed, and the essentials are within close reach. Warm clothes and dry replacements are organized, waiting in the wings. Hatches are closed, sealed, and re-sealed, batteries are replaced, and water tanks filled. The rig has been checked for signs of vulnerability, the wave deflector has been installed, the rudder quadrants tightened, and future sail changes discussed. Once things start to get loud (and they will), our strategy is simplified; there's not much in the way of tactical decisions to be made over the next week or so. The obvious priorities: keep everyone safe, hold the boat together, minimize mistakes, and go as fast as possible towards the first ice gate.
While I obviously hope our trip through the Southern Ocean is a fast one, our time here is relatively short-lived and I've added another priority to my personal list: freaking enjoy it. Nobody gets to come down here, and as nasty as it might be, as awful as it gets, as rough, cold, wet, windy, and miserable as it may be, I've promised myself to look around and appreciate it's specialness. Remember it. At least, that's what I'm prepared to do!
Jono Swain on the helm in fast downwind conditions. PUMA Ocean Racing powered by BERG during leg 5 of the Volvo Ocean Race 2011-12, from Auckland, New Zealand to Itajai, Brazil. (Credit: Amory Ross/PUMA Ocean Racing/Volvo Ocean Race)
Puma Ocean Racing website
Volvo Ocean Race website


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- Filed Under
Turnovers helped keep Oakland in the game over the first 16 minutes. It was the next eight minutes that propelled Siegel to its 15th straight win Friday night.
The No. 2-ranked Stars used a 13-2 third quarter to pull away from the Patriots and score a 45-35 victory in a District 7-AAA clash.
Siegel (15-0, 3-0 7-AAA) forced nine turnovers in the quarter, turned them into seven points and held Oakland (9-9, 1-3 7-AAA) to 1-of-8 shooting from the field, turning a six-point lead into a 17-point lead by quarter's end. ...


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Analyst: iPad mini production may reach 10M units in Q4
updated 11:38 am EDT, Mon October 1, 2012
Pegatron and Foxconn tasked with manufacturing
Contract manufacturers may be preparing to build more than 10 million mini iPad tablets in the fourth quarter, according to Barclays analysts. Most of the new tablets are expected to be produced by veteran iPad maker Foxconn, while Pegatron is said to be tasked with manufacturing approximately three million units.
Production was initially expected to ramp up in September, however the companies are said to have faced component shortages that delayed large-scale assembly into October. Despite the setback, Barclays analyst Kirk Yang remains confident that Apple will keep to its original launch plans.
"As most iPad component vendors ramp up shipments in September that would continue into the fourth quarter of 2012, we do not see any signs of a postponed shipment schedule, suggesting an on-time October product launch," Yang said.
A smaller counterpart to Apple's existing tablets, the mini iPad is expected to integrate a 7.85-inch display surrounded by a comparatively thin bezel. Alleged image leaks show dual speaker grills and the smaller Lightning connector that was introduced with the iPhone 5.
Although the new iPad was incorrectly rumored to be unveiled alongside the iPhone 5, the company is believed to have focused on October to maximize the attention to each device ahead of the holiday shopping season.


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Bearcats quarterback Munchie Legaux is comforted by teammates as he is carted off the field with a knee injury during the fourth quarter.
A season-ending leg injury to Munchie Legaux has left the University of Cincinnati somewhat thin at quarterback, and coach Tommy Tuberville might compensate by moving someone from his current position.
Tuberville confirmed Sunday that Legaux is out for the year. Legaux suffered a severe injury to his left knee in Saturday's 45-17 loss at Illinois, when Legaux was hit high and low by Illini defenders. TV replays showed Legaux's leg bend awkwardly.
Senior Brendon Kay steps back into the No. 1 role, after Legaux started the season's first two games. Redshirt freshman Bennie Coney, from Plant ...


text:
On second thought, SMU's June Jones says Garrett Gilbert's struggles last week were largely on the offensive line
After a career passing performance against Memphis, SMU quarterback Garrett Gilbert had trouble against UCF's pressure. His 16 completions (on 29 attempts) marked the second lowest total this season (15 vs. TCU).
But he was sacked three times and rarely had time to throw downfield. Head coach June Jones attributed that to UCF's quick front, especially end Troy Davis, who had two sacks.
"After looking at the film, he was better than I thought at the time," Jones said. "That was more protection issues. We didn't block very well. He had some issues just throwing the ball accurately too, but he was under duress pretty much the whole game. I thought he pulled down the ball and did some really good things to get some first downs for us."


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Kevin L. Schey, Ph.D.,
Tel: 615-936-6861
The focus of the Schey lab is on the use of mass spectrometry in proteomics and in protein structure determination. The lab is interested in both method/instrument development as well as in applications of state-of-the-art technology to biomedical science. Specific projects are focused on lens protein structure/function in aging and cataractogenesis, imaging mass spectrometry, biomarker discovery via exosome analysis, and shrimp & oyster innate immunity. Other areas of interest include ocular proteomics (retina and glaucoma), signal transduction and cardiovascular proteomics.
Anderson DMG, Zblonczy A, Koutalos Y, Spraggins J, Crouch RK, Caprioli RM, Schey KL. High Resolution 10µm MALDI- Imaging Mass Spectrometry of Retinal Tissue Lipids. J. Amer. Soc. Mass Spectrom., in press.
Wang Z, Lyons B, Truscott RJW, Schey KL. Human Protein Aging: Modification and Crosslinking through Dehydroalanine and Dehydrobutyrine Intermediates. Aging Cell, 13:226-234, 2014.
Schey KL, Wang Z, Wenke J, Qi Y. Aquaporins in the Eye: Expression, Function, and Roles in Ocular Disease. Biochim. Biophys. Acta, 1840:1513-1523, 2014.
Betke KM, Rose KL, Friedman DB, Baucom AJ, Hyde K, Schey KL, Hamm HE. Differential Localization of G Protein βγ Subunits. Biochemistry, 53:2329-2343, 2014.
Chaturvedi R, Asim M, Piazuilo MB, Yan F, Barry DP, Sierra JC, Delgado AG, Hill S, Casero RA, Bravo LE, Dominguez RL, Correa P, Polk DB, Washington MK, Rose KL, Schey KL, Peek RM, Morgan DR, Wilson KT. Activation of EGFR and ErbB2 by Helicobacter pylori Results in Survival of Gastric Epithelial Cells with DNA Damage. Gastroenterol. 146:1739-1751, 2014.
Burns TA, Dours-Zimmermann MT, Zimmermann DR, Krug EL, Comte-Walters S, Reyes L, Davis MA, Schey KL, Schwacke JH, Kern CB, Mjaatvedt CH. Imbalanced expression of Vcan mRNA splice form proteins laters heart morphology and cellular protein profiles. PLoS One 9(2):e89133. 2014.
Schey KL, Grey AC, Nicklay JJ. Mass Spectrometry Analysis of Membrane Proteins: A Focus on Aquaporins, Biochemistry, 52:3807-3817, 2013.
Roberson CD, Qi Y, Gercel-Taylor C, Schey KL, Taylor DD. Identification of specific tumor-reactive antigen using circulating free and tumor-derived exosome humoral responses. Exosomes and Microvesicles, 2013, 1:8. doi: 10.5772/57524.
Ablonczy Z, Higbee D, Anderson DM, Dahrouj M, Grey AC, Koutalos Y, Schey KL, Gutierrez D, Hanneken A, Crouch RK. Lack of Correlation between the Spatial Distribution of A2E and Lipofuscin Fluorescence in the Human Retinal Pigment Epithelium. Invest. Ophthalmol. Vis. Sci, 54:5535-542, 2013.
Nicklay JJ, Harris GA, Schey KL, Caprioli RM, MALDI imaging and in situ identification of integral membrane proteins from rat brain tissue sections, Anal Chem, 85:7191-7196, 2013.
Wang Z, Han J, David LL, Schey KL. Proteomics and Phosphoproteomics Analysis of Human Lens Fiber Cell Membranes, Invest. Ophthalmol. Vis. Sci. 54:1135-1143, 2013.
Anderson DMG, Mills D, Spraggins J, Lambert WS, Calkins DJ, Schey KL. High Resolution MALDI-Imaging Mass Spectrometry of Lipids in Rodent Optic Nerve Tissue, Mol. Vis. 19:581-592, 2013.
Schey KL, Anderson DMG, Rose KL. Spatially-Directed Protein Identification from Tissue Sections by Top-Down LC-MS/MS with Electron Transfer Dissociation. Anal. Chem., 85:6767-6774, 2013.
Grey, AC, Walker KL, Petrova RS, Han J, Wilmarth PA, David LL, Donaldson PJ, Schey KL. Verification and Spatial Localization of Aquaporin-5 in the Ocular Lens. Exp. Eye Res. 108:94-102, 2013.
Schey KL, Grey AC, Nicklay JJ. Mass Spectrometry Analysis of Membrane Proteins: A Focus on Aquaporins, Biochemistry, 52:3807-3817, 2013.
Maddala R, Nagendran T, de Ridder GG, Schey KL, Rao PV. L-Type Calcium Channels Play a Critical Role in Maintaining Lens Transparency by Regulating Phosphorylation of Aquaporin-0 and Myosin Light Chain and Expression of Connexins, PLoS One, 8:e64676, 2013.
Wang Z, Hill S, Luther JM, Hachey DL, Schey KL. Proteomic Analysis of Urine Exosomes by Multidimensional Protein Identification Technology (MudPIT). Proteomics 12:329-338, 2012.
Stamer WD, Hoffman EA, Luther JM, Hachey DL, Schey KL. Protein Profile of Exosomes from Trabecular Meshwork Cells, J. Proteomics 74:796-804, 2011.
Gutierrez DB, Garland D, Schey KL. Spatial analysis of human lens aquaporin-0 post-translational modifications by MALDI mass spectrometry tissue profiling, Exp. Eye Res., 93:912-920, 2011.
Grey AC, Crouch RK, Koutalos Y, Schey KL, and Ablonczy Z. Spatial Localization of A2E in the Retinal Pigment Epithelium, Invest. Ophthalmol. Vis. Sci. 52:3926-3933, 2011.
Wang Z and Schey KL. Aquaporin-0 interacts with the FERM domain of ERM proteins in the ocular lens, Invest. Ophthalmol. Vis. Sci. 52:5079-5087, 2011.
Truscott RJW, Comte-Walters S, Ablonczy A, Schwacke JH, Berry Y, Korlimbinis A, Friedrich MG, Schey KL. Tight binding of proteins to membranes from older human cells. AGE, 33:543-54, 2011.
Reissner KJ, Uys JD, Schwacke JH, Comte-Walters S, Rutherford-Bethard JL, Dunn TE, Blumer JB, Schey KL, Kalivas PW. AKAP signaling in reinstated cocaine seeking revealed by iTRAQ proteomic analysis. J. Neurosci., 31:5648-58, 2011.
Sakakura M, Hadziselimovic A, Wang Z, Schey KL, Sanders CR. Structural Basis for the Trembler-J Phenotype of Charcot-Marie-Tooth Disease, Structure 19:1160-1169, 2011.
Schey KL, Wang Z, Gutierrez DB, Wei J, Grey AC. Novel fatty acid acylation of lens integral membrane protein aquaporin-0. Biochemistry 49:9858-9865, 2010.
Qureshi A, Subathra M, Grey A, Schey K, Del Poeta M, Luberto C. Role of sphinghomyelin synthase in controlling the antimicrobial activity of neutrophils against Cryptococcus neoformans. PLoS One, 5:e15587, 2010.
This page was last updated July 9, 2014 and is maintained by Tina Tsui


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Comments by Deborah1987
There is always to sides to the story, we are only hearing hers. I used to think that Leah was the only sane one on TM2 but i lost all respect when she cheated.
It is voicing ones opinion you dumbass, just like you just did, Your pro Snooki and some of us are anti Snookie! One thing i do agree on is that Vinny is cute but even if i had a chance i wouldnt touch him with a 10 ft pole! Now if i did have a chance to be on the jersey shore, i so wouldnt want the world to think im a freaking drunkrn ass whore cause thats what all the girls are except Sammi. So instead of getting angry at others opinions, make yours and move the fuck on!
You have the date wrong THG!!!! Its October 2011 not 12! Btw I love Demi Lovato and think she is a great inspiration to young women everywhere.
That is sad i feel both ways about Snooki's pregnancy.... One seriously i used to watch the show, it was entertaining for a while till they all became whores/man whores. Like regardless of their ethnicity they are all a disgrace to the American People. Who sits around and watches people get shitfaced and screw Everyone/ Eachother? I for one think we should boycott this pregnancy! Lol jk. But seriously Snooki was the worse one, sleeping with random guys Mike, Vinny, Jionni etc.... Urinating on herself and in public. If she was my child id he sooooo embarrased and ashame to think i raised that hot mess!! And to all the "Dont be hating" comments its not haye, jealousy, or anything its voicing ones opinion!
Well said Miah... Well said!! lol
Christmas*** sorry typo!!
Omg I so need to win this book because Justin Bieber is everything to my daughter and I. He has very good music that is still modern day hip with none of the bad mouthing stuff you hear on the radio now and days. He is very polite and not to mention a little cutie! This would literally make my daughters Cristmas, if I could win this book for her. Please pick us!!!


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The Next 24 Hours – Showers & Snowflakes on Saturday
A weak upper-air disturbance moving into the Tennessee Valley on Saturday morning brings a chance of some rain and a little snow where the precipitation is heaviest. The National Weather Service in Nashville has posted a Winter Weather Advisory for several counties along the Cumberland Plateau for light accumulations of snow Saturday morning into early afternoon.
Here's the specific chance of getting at least a tenth of an inch of rainfall (or the liquid equivalent of rainfall) between 6 AM and Noon and from Noon to 6 PM:
Temperatures will stay on the chilly side all day thanks to the clouds, showers and flurries. Expect highs in the 40s Saturday afternoon, but it will not get quite as cold Saturday night. Temperatures will slowly drop into the 30s by Sunday morning.
Next week does look a little milder; be sure to check out our extended forecast discussion at WHNT.com/Weather!
Climate Data for February 2nd
Sunrise: 6:50 AM
Sunset: 5:09 PM
Average High: 53 Record 73 (1990)
Average Low: 33 Record 3 (1951)
Hours of Daylight: 10:33 (1 minute longer than Friday)
Saturday's Temperature Trend and Rain Chance in Huntsville:
Connect with me!
Google+: Jason Simpson
Facebook: Jason Simpson's Fan Page
Twitter: @simpsonwhnt


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ReviewGist App
Read reviews on the go.
2 August 2013 by Permi Krishna
The best upgradability desktops come with limited features at budget prices since the features like storage capacity, RAM and graphic processors and sometimes the monitor too, can be upgraded only when needed. Hence, most of the upgradability desktops are the traditional Tower, which is one of the desktop form factors.
This list of the best upgradeable desktop is also applicable for the following topics:
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Best Upgradeable Desktop of 2015


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KIDS FIELDBLAZER - MUCK BOOTMO Breakup
The Fieldblazer is the finest waterproof sport boot in its class. Perfect for camping, hunting, and fishing.
Flexible, lightweight, and 100% waterproof, the Kid's Fieldblazer is the perfect boot for your little hunter, fisher or camper.
We Proudly Accept Visa, MasterCard, Discover Card, American Express and PayPal


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Palo Alto Networks, a Sunnyvale, Calif.-based enterprise network security solutions provider, has raised $10 million in additional third round funding from Jafco Ventures, with JAIC and Northgate Capital also participating in the round. The company initially raised $27 million in a first go from lehman Brothers Venture Partners, with the participation of return backers Globespan Capital, Greylock Partners and Sequoia Capital. The current funding takes the total capital raised till now to $64 million.
[via PE Hub]


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WATD Local Weather
Patriots Day Archive
SSMN: Monday April 15th, 2013Posted on April 13, 2013 | No CommentsWelcome to the Monday edition of the broadcast. Rob and Lisa hope you had a great weekend. Here's what we're working on for today: First it's "Patriot's Day" here in the Commonwealth. Plus, it's also Marathon Monday. At 8:11, Jeff & Ilene Hills from "Healthy Appetites" in Plymouth join us […]


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Gerry Floyd and Heather Jones sit with Sydney, who helped Gerry to propose marriage to Heather at an Asheville-area cabin.
- Filed Under
Dog Tag Art, the Asheville-based maker of custom pet tags, has a starring role in a recent engagement story featuring a Cockapoo named Sydney and college sweethearts of five years.
Gerry Floyd, 27, and Heather Jones, 24, of Raleigh, got engaged in a cabin in the mountains near Asheville on the eve of their five-year anniversary.
Yes, there was a romantic dinner in town and, later, a night sky studded with stars back at the cabin. And yes, Gerry had some jitters before popping the question to Heather. ...


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Near-infrared quantum cutting in Ho3+, Yb3+-codoped BaGdF5 nanoparticles via first- and second-order energy transfers
Department of Materials Science, School of Physical Science and Technology, Lanzhou University, Lanzhou, 730000, People's Republic of China
Nanoscale Research Letters 2012, 7:636 doi:10.1186/1556-276X-7-636Published: 22 November 2012
Infrared quantum cutting involving Yb3+ 950–1,000 nm (2 F5/2 → 2 F7/2) and Ho3+ 1,007 nm (5S2,5F4 → 5I6) as well as 1,180 nm (5I6 → 5I8) emissions is achieved in BaGdF5: Ho3+, Yb3+ nanoparticles which are synthesized by a facile hydrothermal route. The mechanisms through first- and second-order energy transfers were analyzed by the dependence of Yb3+ doping concentration on the visible and infrared emissions, decay lifetime curves of the 5 F5 → 5I8, 5S2/5F4 → 5I8, and 5 F3 → 5I8 of Ho3+, in which a back energy transfer from Yb3+ to Ho3+ is first proposed to interpret the spectral characteristics. A modified calculation equation for quantum efficiency of Yb3+-Ho3+ couple by exciting at 450 nm was presented according to the quantum cutting mechanism. Overall, the excellent luminescence properties of BaGdF5: Ho3+, Yb3+ near-infrared quantum cutting nanoparticles could explore an interesting approach to maximize the performance of solar cells.


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Green Festival Exhibitors
Los Arboles Tulum
Tulum, Quintan Roo, Mexico, 77796 - View Map
Ecological Off-Grid Community 95% Conservation & Alternative Energy Use. Sustainable Concept To Live In Harmony With Nature. 5 Acre Titled Lots Within 1200 Acres Of Old-Growth Trees, Tropical Birds, Flora & Fauna. Design The Forest Retreat Of Your Dreams. Minutes To White Sand Beaches, Biosphere, Mayan Ruins, Eco-Parks & More.


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A self tan toner? Never heard of one, I thought all self tans were creams. Very interesting products, thanks for posting about it! And the thing about the smell, I totally understand what you mean!
Skin care
Lancaster Self Tan
I try to avoid sun as much as possible. But that does not mean that I don't like gently sun-kissed tan. Just a little bit, so it looks fresh and healthy. Self-tanning creams and lotions are my must have products for summer … even on vacation by the sea. This year I bought Lancaster Self Tan.
Lotion is very clear and reminds me of face toners. I apply it every second or third day as part of my morning routine … after toner and before face cream. I love the dosage system – you put cotton pad onto the cap, press twice and you get perfect amount to cover face and cleavage.
It takes day or two for slight color to emerge. I love the scent. It's not one of those burnt smells but nice and fresh.
What bothers me? Alcohol Denat. in the beginning of INCI list. But Gejba said it's not that big of a deal as I use it only every once in a while. I love everything else about this product, so I would recommend it.
I like another self-tanning product – L'occitane Do Brasil Sunshine Lotion. Milk formula, nice to apply with lovely scent that reminds me of coconut sun creams. This one also gently tans the skin. I'm not sure it's still sold though. But if you find it, give it a try.
The thing that I most hate with self tanning products is the smell. That is why I love the products I showed you today even more.
Enjoy in the sunshine protected with high factor sun creams and self tanning products.
5 Comments
Tudi meni je najbolj neznosen smrad teh samoporjavitvenih krem, ampak ker sem precej bela jih vseeno uporabljam. Bom probala najti tole


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Over on SO several questions have been tagged as compass when they should have been classified as compass-css instead. What's the proper process for requesting they get retagged properly? I lack sufficient mojo to do it myself and I've flagged the questions, but that doesn't seem to be getting processed. Needless to say, searching for help on style issues with the search gurus probably isn't efficient.
What is meta? ×
Meta Stack Exchange is where users like you discuss bugs, features, and support issues that affect the software powering all 150 Stack Exchange communities.
There are 4 ways:
You can suggest an edit yourself - as long as the tag you wish to use already exists. If you don't have enough reputation to create a tag the only thing you can do (apart from nothing) is raise a flag.
All flags will be looked at eventually, however, there's no guarantee that the moderator who sees your flag will agree.


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Update: Matthew McGee last night won a Helen Hayes award for outstanding supporting actor in a play. That's a big deal!
Fresno State's Brad Myers watched the award presentation online and got a little choked up at McGee's acceptance speech, in which he thanked his parents (who traveled from California for the ceremony) and acting professors Myers and Leslie Martin. (You can listen to McGee's heartfelt speech, in which he admitted he was scared to make the move to D.C. but was so glad he took the chance, here. Go to the 1:14 mark.)
How important is this award to McGee's career? One of the hosts noted that a Helen Hayes award is highly esteemed by people on Broadway, and that having one in your back pocket can get you through lots of doors.
Congratulations, Matt!
Original post 01/29/13: Fresno's Facebook theater community is abuzz with the news that recent Fresno State graduate Matthew McGee scored a nomination for outstanding supporting actor in a play in the 29th Helen Hayes Awards, which represent excellence in Washington, DC-area professional theater. In doing so, he's in the company of such nominees as Kathleen Turner, Paul Downs Colaizzo and Christopher Sieber.
McGee appeared in such local Fresno productions as "Urinetown," "Welcome Home, Jenny Sutter" and "Measure for Measure" at Fresno State, and "Of Mice and Men" at CenterStage Clovis Community Theatre. He's also quite a set designer as well.
Beehive readers may remember that McGee represented Fresno State in 2011 at the American College Theatre Festival in Washington, D.C., the premier collegiate acting competition in the nation. He didn't win the top prize. But he scored big anyway: McGee was awarded a paid nine-month internship with The Shakespeare Theatre Company in Washington, a top-notch professional company.
In fact, I think it's pretty clear McGee's internship turned out to be a much bigger boost to his career than if he'd won the top Irene Ryan Acting Scholarship prize. He parlayed his D.C. acting experience into a professional role at the Constellation Theatre Company in the play "Taking Steps," for which he earned his nomination. That's right: He got nominated for a prestigious acting award for his first professional role. Can't beat that. Way to go!
Theater trivia time: What actress with strong Fresno theater roots won a Helen Hayes award in 2008? I'll post the answer tomorrow.
Donald Munro
Latest posts by Donald Munro (see all)
- Win tickets to Fresno Philharmonic holiday concert - November 25, 2015
- Heidi Blickenstaff soars in PBS special 'First You Dream' - November 19, 2015
- A great way to introduce Fresno Phil candidates - November 18, 2015


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New Series from In The Life takes a Look at Gay Rights Across the United States
Tonight, public television stations nationwide will begin broadcasting the show "Remaining Vigilant," an episode from IN THE LIFE. The episode features two installments of In The States, an ongoing series covering local LGBT activists campaigning for equal rights and protections at the state level.
In The States: Iowa brings IN THE LIFE to the American heartland where, in an attempt to repeal marriage equality, social conservatives have used unprecedented tactics in a campaign with national implications. Iowa poses an important question to the rest of the country: Should voters decide whether gay and lesbian couples have the right to marry?
Also in this episode, IN THE LIFE heads to Ohio, a state with few legal protections for LGBT people. Ohio legislators not only banned same-sex marriage, but barred unmarried state employees from receiving benefits for domestic partners; it is legal to fire LGBT people in Ohio because of their sexual orientation or gender identity; and transgender Ohioans lack the most basic civil rights. In this look at the LGBT experience in a state where progress is slow, we meet locals with deep ties to their community committed to a long battle in the state that they love.
On May 1st, Remaining Vigilant begins airing on public television stations across the country and will be available for free video streaming from the In The Life Media website. To find out when it will air in your local area, or to stream it, go to ITLMedia.org.


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Paul Bosworth
- Filed Under
Paul Bosworth was living the high life with a high-powered, high-pressure, high-paying job in Arlington, Va.
That all came to an abrupt halt on Sept. 11, 2007, when he suffered a brain injury. He'll share his experiences and offer hope for other survivors during the Brain Injury Association of Louisiana's annual conference, to be held March 20-21 in Bossier City. Other speakers will include medical experts and ThinkFirst of the Ark-La-Tex's Voices for Injury Prevention.
On that day seven years ago, Bosworth was in his home office doing research on a potential new $6 million client while at the same time instant messaging, talking on the phone and wolfing down some chicken fried rice - a normal day. Until he choked, blacked out and fell, striking his head. When he regained consciousness, he had vision and balance problems, so he called his girlfriend, who picked him up and took him to the hospital. He was treated, given pain pills and released, and his girlfriend was instructed to keep a close eye on him.
In the following days, he tried to get back to work, in spite of the continuing symptoms.
"Ten days after the injury, post-concussive syndrome parked itself on my neurological system," said Bosworth, who suffered massive cluster headaches, trouble walking, talking and counting, memory loss and bouts of frustration.
But it would take a year to get a diagnosis.
Post-concussive syndrome often clears up in about a month, but in other individuals, it can last years or even be permanent, according to the U.S. National Library of Medicine, National Institutes of Health.
Unable to maintain his job, Bosworth moved back to Louisiana, his home state, settling in Lafayette. Now, he does volunteer work on both the state and national level.
"I give back as often as I can by doing talks in the community," he said. He also moderates a support group and has spoken to neuropsychology students about his experiences.
Bosworth says there is a shroud around brain injury and that it's very slowly being understood and even slower being accepted.
"If you looked at me, you'd think 'he looks fine'," Bosworth said. "But test me over time and you'll ask 'what happened to you,' 'what's wrong with you'?"
Bosworth says he's learned new strategies, gained insights and fit himself into a new normal. He's also tried cutting-edge brain therapy. "I spent my parent's inheritance on hyperbaric oxygen therapy. I would do it again 10 times over.
"Because I want to get better, I will get better," he said. "It's called rewiring. Will I be the same person again? No. I'm rewiring to get closer to a new normal, which is different from my old normal."
He wants other survivors to know they are not alone.
"I was so alone after my injury that I felt hopeless. There are strategies out there, there are ways we can rewire and have a life after a trauma, whatever that means."
In spite of his losses, Bosworth sees rewards in his new life.
"I had a good living. Now I have a good life."


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Yes you read that correctly. Rob Wallace was checking out the weather on the internet when one of those silly banners came down. Of course he was a little curious so he clicked on it. Seems there is a scholarship for those of you who like to bum around.
Bad news, Rob won it for his extra cool video he made with some of his Knoxville peeps.
So last week he packed up his winter gear and headed to Colorado. You know Breckenridge, Vail, where the kind snow is yo.
Seems he thinks 20 below zero is a little cold. Here is the website where you can see all the videos that folks made.
Congrats Rob! Make us proud, you bum!