text:
We were pretty excited to see Will Ferrell back on the Saturday Night Live stage…and he didn't let us down.
The SNL alum who killed when it came to impersonating the likes of George Bush, Janet Reno and more during his tenure on the show, returned to his old stomping grounds to host the late night laugher for the third time, kicking off his stint with a Mother's Day shoutout straight from his "brain place."
MORE: Will Ferrell vs. Zach Galifianakis: Who Gets Your Vote in The Campaign?
I know what I'm about to say could cause some controversy, but I love my mom!" Ferrell said in his opening monologue. "There ya go TMZ, that's for you."
And then when he went on to try to honor his mom with a Mother's Day tribute, using his own interesting words.
"I'm not so great with words…other people write what I say," Ferrell said, pulling his mom up on stage. "The words I'm saying right now are from my brain place to my mouth hole. Mom, I have love. I love the way you be, you be a big ol' mommy."
"You made milk for me…like the lady from the cover of Time magazine….I wanna cover you in super glue and roll you in flowers…if you were attacked by a dozen ninjas wearing crotchless panties, I would fight them. I would fight them hard."
So, did the Eastbound & Down star bring back any of our fave characters and impressions when he was done, um, honoring his mom?
And he brought a few more SNL alums (and celebs) along for the ride while he was at it.
Ana Gasteyer was on hand to reprise the duo's Marty and Bobbie Culp skit, performing Nicki Minaj's "Super Bass," One Direction's "What Makes You Beautiful" and Adele's "Rumor Has It," with Ferrell at a LGBT high school prom the way only the quirky pair knows how.
Meanwhile, Will Forte came back for an ESPN golf tournament bit as Greg Stink, co-hosting the show with Pete Twinkle (Jason Sudeikis). The tournament happened to be sponsored by Stayfree Maxi Pads, which the hosts made sure to mention every few seconds. Ferrell was also on hand as drunken correspondent Randy, who needed some extra time to sober up before reporting.
"I used to be a stripper," Randy said. "I know with this body…I used to be way fatter then…but it was too much stress on my back. So, I lost weight, got a butt reduction and went into broadcasting."
But, those weren't Ferrell's only highlights.
MORE: Will Ferrell, Kristen Bell, Joel McHale and More Share Mean Tweets on Jimmy Kimmel Live
In the cold open, the comedy star brought back his dead-on impersonation of George Bush, this time playing the former president as the imaginary friend of a pouty vice President Joe Biden (Sudeikis).
"Mission accomplished…that's just something I like to say when a problem isn't solved, but I don't want to talk about it anymore," Bush (Ferrell) said.
Justin Bieber and Justin Timberlake were on hand for the celebration of show's 100th digital short, kicking off an epic musical number featuring Shy Ronnie (Samberg), and a killer "D-ck in a box" remix that featured a cursing Natalie Portman, Timberlake and Samberg, Jon Hamm as a shirtless saxophonist named Sergio, Michael Bolton as Jack Sparrow, Usher and Ferrell.
"I do endorse this song," Ferrell crooned during his cameo. "My Name is Will Ferrell and I'm sucking my own dong."
MORE: Will Ferrell Movie Sex: "A Lot of Butt Massaging," Says Costar
Aside from performing "Climax" and "Scream," Usher also showed up in another skit—the "Funkytown Debate," playing Ferrell's running mate, Mr. Galactic Fantastic.
Needless to say, this particular SNL was one star-studded affair.
Even, Liam Neeson popped up to make an appearance during the "Weekend Update" for Samberg's "Get in the Cage" with Nicolas Cage (Samberg).
So, tell us, what did you think of Ferrell's third stint as SNL host?
Sound off in the comments.


text:
Now connecting over 33 million members worldwide!
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50-55 years old
Collegiate High School Sports College 1981
Blackpool, Lancashire, United Kingdom
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Pahrump Valley High School 2005
Pahrump, Nevada, United States
35-40 years old
Sheringham High School and Sixth Form Centre 1995
Sheringham, Norfolk, United Kingdom
40-45 years old
The Immingham School 1988
Immingham, Lincolnshire, United Kingdom
35-40 years old
Wellington Point State High School 1996
Wellington Point, , Australia
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text:
|Cell age-dependent changes in deformability and calcium accumulation of human erythrocytes.
MedLine Citation:
|PMID: 3919766 Owner: NLM Status: MEDLINE
|The deformability of human erythrocytes was measured in a rheoscope, as a function of intracellular calcium content (varied with ionophore (A23187) and CaCl2) without complete ATP depletion and echinocytic transformation. Loading calcium into intact erythrocytes (calcium content: 16.8 mumol/1 packed cells = 1.48 amol per cell), the cell volume and energy charge gradually decreased. Further, the membrane fluidity of the lipid portion decreased without crosslinking of membrane proteins. A distinct transition from deformable to undeformable cells was observed by the rheoscope technique: i.e., 50% transition occurred at 40-50 mumol calcium/1 packed cells (= 3.5-4.0 amol per cell) and more than 90% above 100 mumol/1 packed cells (= 6.5 amol per cell) at a shear stress of 140 dyn/cm2. The deformable cells maintained their deformability to ellipsoidal disks independent of the average calcium content. The underformable cells, separated as high-density cells by density gradient centrifugation after calcium-loading, showed lower glucose-6-phosphate dehydrogenase activity than low-density-deformable cells; thus, the calcium-loaded, undeformable cells were presumably in vivo aged cells. The younger cells, fractionated as low-density cells from intact erythrocytes, were more deformable than aged cells. Upon calcium-loading, the younger cells restored their cell volume and deformability, while the aged cells, containing originally more calcium and less ATP, decreased their volume and became undeformable. Therefore, calcium accumulation by ionophore-CaCl2 takes place in preference to aged cells of lower energy metabolism, and leads to cellular dehydration and loss of deformability, due to condensed hemoglobin and altered membrane organization.
|T Shiga; M Sekiya; N Maeda; K Kon; M Okazaki
Related Documents :
|10366696 - Gaba induces proliferation of immature cerebellar granule cells grown in vitro.
17383636 - Chloride transport in ncl-sg3 sweat gland cells: channels involved.
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Publication Detail:
|Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Detail:
|Title: Biochimica et biophysica acta Volume: 814 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1985 Apr
Date Detail:
|Created Date: 1985-05-23 Completed Date: 1985-05-23 Revised Date: 2006-11-15
Medline Journal Info:
|Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS
Other Details:
|Languages: eng Pagination: 289-99 Citation Subset: IM
Export Citation:
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|MeSH Terms
Adenosine Triphosphate
Calcimycin / pharmacology
Calcium / blood*
Calcium Chloride / pharmacology
Energy Metabolism
Erythrocyte Aging*
Erythrocyte Deformability*
Reg. No./Substance:
|10043-52-4/Calcium Chloride; 52665-69-7/Calcimycin; 56-65-5/Adenosine Triphosphate; 7440-70-2/Calcium
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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text:
In response to a Macworld article, TidBits' Chris Pepper elaborated on ways to run Software Update, Apple's means of delivering updates and patches, on your own schedule. Beginning with the fact that Software Update schedules its next update based on the time it's currently being run, setting the time for the next update is as easy as running it manually at the time you want it to be scheduled for in the future.
Later, Pepper delves into the command line method of updating, using the
softwareupdate tool (which we've talked about on TUAW, too) to run it from Terminal. Taking that a step further, it's suggested that you run the command from
cron, a UNIX command for scheduling tasks, to automate the command-line updates. However, while it still works fine and is perfectly capable of the task,
cron has technically been deprecated in OS X since Tiger. I thought I'd mention the newfangled "Mac OS X way" of handling scheduled tasks, and demonstrate a little of its flexibility.
Launchd is Apple's replacement for several UNIX ways of doing things, including
init, rc.d scripts and
cron. It provides a uniform, XML configuration method and -- in many cases -- is more secure than the replaced methods. Launchd can trigger applications and scripts at boot time, at intervals or even when a file or the contents of a folder change. It can also make sure a daemon or an application keeps running, with the ability to respawn and throttle it. If that's just a bunch of nerd-speak to you, don't worry, this isn't going to be an overly technical post. You can read more specifics about launchd on Apple's developer site, if you want more geeky goodness.
Launchd configuration files, like much of OS X, are XML files. Each process has one, and they can exist just about anywhere. A tool called
launchctl is used to add and remove them from
launchd. While these files are technically human-readable, they're not the most fun to create and edit. In the interest of keeping this as non-technical as possible, I'm going to use a very handy utility called Lingon. The latest version (2.1.1) can be found at Sourceforge. It's no longer under active development, but it's working fine in Leopard and Snow Leopard. Grab a copy, put it in either your Applications folder or into Applications/Utilities, and launch it.
You'll see all of your existing daemons and agents in Lingon's sidbar. Unless you know exactly what you're doing, you'll generally only want to edit/add scripts in the "My Agents" section to avoid breaking anything at the system level. Create a new script using the plus button in the upper left, and name it something unique in section 1 of the edit area; I prefix my launchd scripts with my own name, e.g.
com.brettterpstra.awesomescript, but anything will work.
Section 2 is where our command goes. In this case, we're running the
softwareupdate command, and we want it to automatically download any available updates in the background. We'll use
/usr/sbin/softwareupdate --download --all in that field.
Section 3 gives us the various options for running the command. In Lingon's interface they're pretty self-explanatory, so I won't go through each one. We'll just use "At a specific date:," "Every Day," and whatever time works best for you (and your bandwidth allowances). Make sure the enabled checkbox in the upper right is checked, hit the save button at the top, and you've got your own Software Update scheduler. Change the time at will, or use one of the other options to control how often it runs. If you enable this, you'll probably want to disable the automatic checking in Software Updates panel in System Preferences.
There are other possibilities, too. For example, if you wanted to be notified as soon as possible about available updates, you could write a script that ran
softwareupdate with the "-l" option (to list available updates without downloading them), parse the output and have it send you an email or a direct message if it found any updates. Run it about every 15 minutes and you could be among the first to know about an update! You can also use the launchd manager (
launchctl), or Lingon to disable background processes that other programs have added, but that you don't want running. Whether you're a UNIX user still hanging on to cron, or are just a regular user who wants something besides iCal for scheduling scripts and launching applications, this will hopefully get you started with the 'new' OS X way of doing it.
- Key specs
- Prices
- Discussions
- Type Computer OS
- Source model Closed, w/ open source
- Architecture 64-bit
- Released 2014-10-16


text:
Tuesday Apr 13 2010
Lady Trojan basketball team honored
By: Brett Ransford/Telegraph Correspondent
It rained on their parade on Sunday, but the Oak Ridge girls' basketball team was still honored for winning the California Interscholastic Federation Division I state championship. Ignoring the downpour under cover of trees and umbrellas, supporters gathered outside Yogaberry at the El Dorado Hills Town Center to present the girls their proclamation. Along with El Dorado County Supervisor John Knight, the presentation featured the team posing for television cameras, photographers and fans. Initially the plan was to parade the squad down the boulevard, but that was squandered by weather. Despite the conditions, the Lady Trojans were wide with smiles and soaked up the stardom. Before they were state champions, Yogaberry Owner Darcee Rotz and Tracey Kellogg of Kellogg's Portraits began a marketing campaign months ago featuring the girls of Oak Ridge basketball. Now state champions the flavors at the yogurt shop are 'Trojan Tart, Rebound Raspberry, State Champion Chocolate and Coach White Vanilla.' "We call them the Yoga Models," said Rotz. "The rain is kind of a bummer because I was going to have them come down for a signing but Tony Mansour heard about it and wanted to use the whole town center for a parade. Now that they're done with basketball, of course, all of the girls want jobs, though." Oak Ridge senior Sara James, who's earned an athletic scholarship to Stanford, enjoyed the event. "It's really awesome to see the community come out despite the rain," James said. "It's so much fun to get the team and fans together again. I'm really excited to go to Stanford, but I'm not going to look over the rest of my senior year. We've got a lot of fun things coming up so I'm just going to continue to improve and have as much fun as I can doing it." James was not the only person having fun on Sunday. The autograph signing was brought indoors across the street from Yogaberry to where Kellogg will have her new studio. Inside the girls lined up to sign autographs for fans like the Costamagna family. Father Chris and his spouse Kelly attended Oak Ridge years ago. Kelly, who also is a former basketball player at the school, and Chris took their daughters Gabby (11) and Sophie (9), to Bakersfield for the championship game. "It's amazing and fun to see Oak Ridge basketball at a different level," said Kelly. "Our daughters told Coach White the night they won, 'We're going to be in this tournament when we're at Oak Ridge.' Their whole rooms are decorated in Oak Ridge basketball stuff and we have pictures of a couple of the girls holding trophies that we're going to have them autograph." Other fans include Joe Hoffman and his daughter, Kristen, 10, and son, Jake, 8. "The kids have been following it all along," said Hoffman. "My niece and nephew play for Oak Ridge as underclassmen so we've been out to a lot of games. We didn't know what to expect so we came down to check it out and it has worked out well and been really fun." Holding his team poster autographed by the entire Trojan team, Jake was happy. "It is pretty awesome; I got autographs from all of the girls."


text:
I've said before that I believe a lot of the recent issues with SEO (see Jason Calacanis, Dave Pasternack) might be resolved if everyone could agree on what "SEO" means.
Both Calacanis and Pasternack agree that the effects of ethical SEO are good. They also agree that things like page design and site structure are good. Most SEOs would agree with those points as well. Where they disagree is whether those additional disciplines are part of SEO.
John Andrews today wrote about this issue today in a post called "The Secret Side of SEO." Andrews differentiates technical, on-page SEO from more strategic SEO tactics, which he calls "competitive webmastering."
"'Strategic SEO' is not SEO at all, but competitive webmastering, which uses SEO tactics. The same is true for 'optimized SEM' and the newer 'social media optimization.' They are tactics, which must be executed within a plan that has goals and objectives," he writes.
He also expands on a discussion with online marketer Natasha Robinson, who was having trouble explaining to an engineer that SEO is about more than just getting more pages indexed.
"If you are still working to get your client's sites fully indexed in Google (or worse, still paying an SEO 'firm' to get all of your pages indexed), I'm sorry to hear of your continued inability to get SEO and the web. It doesn't matter so much how many of your pages are indexed, but it matters which of your pages are indexed and whether or not they are indexed such that they appear in the right SERPs for your business objectives," Andrews writes.
Andrews finishes off the post with "6 Things Your SEO Firm May Not Have Told You," which is filled with tips on what is, and is not, important to include in your SEO/competitive webmastering strategy.


text:
Established in 1992, the Occupational Injury Prevention Program monitors occupational injuries in Alaska and disseminates prevention recommendations. The program is also responsible for administering the state-based Fatality Assessment and Control Evaluation (FACE) project under a contractual agreement with the National Institute for Occupational Safety and Health (NIOSH) Alaska Pacific Regional Office.
- Frequently Asked Questions (F.A.Q.)
- Alaska FACE Facts
- FACE Investigative Reports
- Occupational Injury Epidemiology Bulletins
- National Institute for Occupational Safety and Health (NIOSH)
- Occupational Safety and Health Administration (OSHA)
- U.S. Coast Guard 17th District
- Mine Safety and Health Administration (MSHA)
- National Transportation Safety Board (NTSB)
- Federal Aviation Administration (FAA)


text:
Yesterday, we talked to Therese Sparby and I asked her 3 questions about her experience embracing the power of relationships in her business. She shared that and provided some great tips for our readers too. Today, let's talk to one of my oldest online friends (our friendship is old…not my friend :)), Kelly McCausey.
Before we get into that, remember, you can still join us for Competitors into Profits. If you want to to ensure you're doing what you can to ensure you're developing meaningful relationships…instead of wasting time wading through the sea of social media superficiality, join us.
Now let's get to what Kelly has to say…
If you don't know Kelly McCausey already, she's a podcaster, blogger, teacher and just about anything online business owners could want to uplift their business. She runs her podcast at Solo Smarts and a mastermind group at Solo Masterminds. Kelly and I actually created the mastermind group together in 2004, but it's undergone some branding over the past couple of years. One of the areas Kelly really shines is not only connecting with others, but connecting other people together. That's why I had to ask her these 3 questions.
Q: What difference has building relationships made to your business?
A: This is the sort of question that makes my heart pound.
Relationships in my business has been everything. From the day you (Alice) invited me to partner with you on a membership site (she's talking about Solo Masterminds) through 'til today, every great thing I've done has involved a relationship.
I am a solopreneur so I do have a lot of solo projects, but even those things that I've created on my own, I've relied on relationships to build buzz and promote them.
You know, I'm a happy loner much of the time. I don't need a lot of time and attention from others to be happy – but I do need SOME and I can't imagine what my work at home life would be like without small daily connections with friends.
One area I've struggled with in relationships is letting people speak into my business. It's a matter of trust and pride and more than a little fear of being judged. This year I determined to let more people advise me and to be more open to that advice because it has a huge impact on me personally and on my financial success.
Q: What have been your best strategies for meeting new and influential people?
A: Having a Podcast has always been a great tool for meeting people. Even popular people appreciate being invited as a guest on a podcast and it has opened a lot of doors for me.
In the last year I've used content curation to establish new relationships by sharing and linking to great content. When I take the time to share someone's content through curation and then work to promote it, it's gets the author's attention and often earns me a thank you.
Q: What piece of advice do you have for someone who needs to start reaching out more?
A: Before you head out to make friends, take good care of your home base.
When I meet new people I always check out their blog. I explore their about page and click around social media to get a feel for who they are and what they do. I'm most interested in getting to know people who have a clear message about who they are, who they serve and where they're headed in business.
Finally, don't psych yourself out or think successful people aren't interested in getting to know you. I have a couple powerful business relationships right now that I count myself very fortunate to have and in both cases I didn't know them a year or so ago. How sad would it be if they hadn't reached out?
How This Applies to You
I think it's quite common for online business owners to be a bit shy or introverted. I am definitely one of those, but you probably can't tell…unless I've told you that before. Kelly is also one of those people, but she's still forged very meaningful relationships that have expanded her business in so many ways. If you're on the shy side, that's no reason for it to hold you back.
A podcast, or even single interviews, are a great way to break out of your comfort zone and gives you a great reason to approach new people. After all, you just want to interview them and give them extra exposure. We'll be talking about interviewing in Competitors into Profits and giving you some very useful tools to make it a lot easier to get people to say yes and create engaging interviews.
A mastermind group is also a good way to bring great minds together and expand your friendships. Now, the membership site that Kelly and I originally created isn't a traditional mastermind group as it's more open, but it still brings together like minded people and has allowed both of us and the members to make great connections. We'd love it if you joined Solo Masterminds if it something that fits for you. We'll also be talking about creating your own mastermind group in Competitors into Profits, so I'd love to have you there as well.
So…what are your next steps?


text:
|Rangewide population genetic structure of the African malaria vector Anopheles funestus.
MedLine Citation:
|PMID: 16313589 Owner: NLM Status: MEDLINE
|Anopheles funestus is a primary vector of malaria in Africa south of the Sahara. We assessed its rangewide population genetic structure based on samples from 11 countries, using 10 physically mapped microsatellite loci, two per autosome arm and the X (N = 548), and 834 bp of the mitochondrial ND5 gene (N = 470). On the basis of microsatellite allele frequencies, we found three subdivisions: eastern (coastal Tanzania, Malawi, Mozambique and Madagascar), western (Burkina Faso, Mali, Nigeria and western Kenya), and central (Gabon, coastal Angola). A. funestus from the southwest of Uganda had affinities to all three subdivisions. Mitochondrial DNA (mtDNA) corroborated this structure, although mtDNA gene trees showed less resolution. The eastern subdivision had significantly lower diversity, similar to the pattern found in the codistributed malaria vector Anopheles gambiae. This suggests that both species have responded to common geographic and/or climatic constraints. The western division showed signatures of population expansion encompassing Kenya west of the Rift Valley through Burkina Faso and Mali. This pattern also bears similarity to A. gambiae, and may reflect a common response to expanding human populations following the development of agriculture. Due to the presumed recent population expansion, the correlation between genetic and geographic distance was weak. Mitochondrial DNA revealed further cryptic subdivision in A. funestus, not detected in the nuclear genome. Mozambique and Madagascar samples contained two mtDNA lineages, designated clade I and clade II, that were separated by two fixed differences and an average of 2% divergence, which implies that they have evolved independently for approximately 1 million years. Clade I was found in all 11 locations, whereas clade II was sampled only on Madagascar and Mozambique. We suggest that the latter clade may represent mtDNA capture by A. funestus, resulting from historical gene flow either among previously isolated and divergent populations or with a related species.
|A P Michel; M J Ingrasci; B J Schemerhorn; M Kern; G Le Goff; M Coetzee; N Elissa; D Fontenille; J Vulule; T Lehmann; N'F Sagnon; C Costantini; N J Besansky
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Publication Detail:
|Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Detail:
|Title: Molecular ecology Volume: 14 ISSN: 0962-1083 ISO Abbreviation: Mol. Ecol. Publication Date: 2005 Dec
Date Detail:
|Created Date: 2005-11-29 Completed Date: 2006-06-15 Revised Date: 2008-11-21
Medline Journal Info:
|Nlm Unique ID: 9214478 Medline TA: Mol Ecol Country: England
Other Details:
|Languages: eng Pagination: 4235-48 Citation Subset: IM
|Center for Tropical Disease Research and Training, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
Export Citation:
|APA/MLA Format Download EndNote Download BibTex
|MeSH Terms
Africa South of the Sahara
Anopheles / genetics*
Base Sequence
Cluster Analysis
DNA, Mitochondrial / genetics
Genetic Variation*
Genetics, Population*
Haplotypes / genetics
Insect Vectors / genetics*
Microsatellite Repeats / genetics
Molecular Sequence Data
Population Dynamics
Sequence Analysis, DNA
|Grant Support
Reg. No./Substance:
|0/DNA, Mitochondrial
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bayesian inference of evolutionary history from chloroplast microsatellites in the cosmopolitan weed...
Next Document: Sequence diversity of the MHC DRB gene in the Eurasian beaver (Castor fiber).


text:
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Serving a selection of delicious simple snacks, tempting treats, afternoon teas, freshly brewed coffee and drinks
This is a great place to start or end your day. Sink into our comfy sofas next to the feature fireplace and just relax.
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Nice, hope it goes well for them.
Grab hand picked indie games, available for a heavily discounted price every couple of weeks at Indie Royale.
You've heard of Minecraft, right? You know how alpha funding works then -- this week's Royale is alpha-powered!
Posted by INtense! on Feb 23rd, 2012
The Indie Royale game bundle site has just debut their first-ever Alpha Collection, with buyers being able to play and help fund to completion three fully-featured, in-development titles.
This now-available bundle was hand-picked to include three games with immediately fun, playable 'alpha' versions and current or imminent PC, Mac and Linux versions. Each of the developers has committed to providing updates regularly to all Indie Royale buyers until the title is complete.
Leading off the the Alpha Bundle is SMP's Towns, a city building and management game mixed with an RPG that draws inspiration from titles spanning Dungeon Keeper, Dwarf Fortress and Majesty. Instead of playing the hero who delves deep into the dungeon, players oversee the town that houses and caters the hero's needs.
Along the way, players can craft unique weapons, obtain randomized loot and build a settlement capable of holding back the forces that rise up from the active dungeon upon which the town sits. Towns is available on PC, Mac, and Linux.
The second title being Alpha funded is developer Phr00t's 3079 -- an alleged lovechild of Minecraft and Fallout, with a block-like world, futuristic action, and role-playing elements played in a first-person perspective. 3079's randomly generated areas, buildings, items, quests and characters make it an entertaining open-world experience, with Alpha funding helping to power many new additions over the next few months. PC, Mac, and Linux funders can dive into the single player and online multiplayer action now.
Finally, the Alpha Collection's sleeper title is Wyv and Keep: the Temple of the Lost Idol is a lusciously pixelated 2D co-op puzzle platformer from A Jolly Corpse. Dubbed as a more fiendish version of Blizzard's classic The Lost Vikings, players can control Wyv and Keep with one keyboard, and two players can play locally or online.
Players use boxes and even their own bodies to traverse gaps, activate switches, collect treasures, and reach exits in dozens of levels. A Windows PC build is currently downloadable, and purchasers' contributions will help fund the Mac and Linux versions of the game. These are planned to become available for all Alpha Collection buyers in the next 3 to 6 months.
The Alpha Collection launches with a recommended €/£/$10 for the titles (downloadable as standalone executables and also redeemable via Desura), but a fluctuating minimum that starts at $5 USD and moves up from there. Generous purchasers will bring the minimum bundle price lower over the seven days of the bundle.
More information on the Alpha Collection, including real-time statistics and its current price, is available at its official website or via its Facebook and Twitter pages.
Nice, hope it goes well for them.
Definitely an experiment - see if we can get a bit of the doublefine kickstarter like love for promising upcoming games.
Personally I'm unsure if having a bundle will work, what I can see happening more than anything will be these developers getting less per unit and having to split capital.
These games weren't expensive as is, so there's no perception of "Value" that wasn't already being offered anyway. As has been said many times before about these bundles, they may be in fact doing more damage than good. I hope your experiment goes well though. I'm very interested to see how you cope with community funding in the future, and I'm glad you beat everyone else by implementing it into Desura ;). If you can generate so interest via game journalists, I think you'll get more traffic coming into Desura. Best of luck Scott ;)
Although they wont be making as much money as if they were to sell individually, they will probably make a fir bit through the bundle.
I wasn't interested in 3079 or that other game, and probably wouldn't have bought towns, yet I bought the bundle at £6. That splits about £5 between them or so.
The other way to look at it is that about 8,000 bundles sold so far, so at about £3 a bundle that is £24,000. Minus Taxes, any cuts for Desura ect they will still have about £18,000 between them so far (so about £6,000 each). I'm sure this amount of money will help with their development (new sounds, music, models ect) as well as Advertising to help sell more copies at full price in the future.
I like the idea but I think this is the fewest games in an indie bundle to date.
True, but maybe they will add in another game soon.
Afaik Overgrowth and NS2 once did a bundle. That was 2 indie games in a bundle, so not yet :P The one game bundle has yet to be invented though xD
The one game bundle was already invented, the Humble Frozen Synapse Bundle:
<- you could get only Frozen Synapse (another bundle ONLY if you paid more than average)
Ah right I remember that.
So there, the one game bundle.
What's next a game bundle with only sounds tracks and dlc but no games?
There was Voxatron Alpha debut bundle with 1 game, but then they added tons of games for free :D
idea behind this bundle is to raise more for the developers - hence fewer games
Towns sure is worth it
Yha, I'm playing the tutorial right now. The music is a tab repetitive though.
bought it even if I already owned towns. nice bundle.
bought just for 3079 but I am really liking towns
Seems really cool, I might buy, but I need to find my credit card...
Towns and Wyv & Keep intensely appeal to me, 3079 does in theory but in practice not so much... but I'll go into all three with an open mind. probably my favorite bundle since the days of yore
Good games, however, lately I was into purchasing non-free, but less donation. i won't be trapped again. I will only give money to those freetoeveryone to share/play.
Wyv & Keep so far has been good fun, so it was worth it, hope to check out 3079 soon, towns looks like it will be great but is still a bit far off me wanting to play.
Great job :)
Thanks everyone and indieroyale for your great support!
I must say that even if this bundle isn't a major successful move from our part, at least i am glad it brought wyv and keep to my attention, a game i never (but should have) heard of. it is a superb game.
No Project Zomboid? What a bummer. I was pretty sure it would be on this bundle.
Yeah I'm surprised by this as well. If PZ was added, this probably would've made the bundle work properly, because if you take a successful game and bundle it with relatively unknown titles, then it draws attention where there otherwise wouldn't have been.
I was looking forward to it due to Project Zomboid, but without it, I'll pass... These "Royale" bundle start to get worse and worse =/
Yea, project zomboid and survivals of ragnarök needs a bundle! I purchased this bundle and to be honest, Towns and 3079 sucked. Wyv and Keep isn't released yet =/
NOTE: I'm on mac
:D Agree with the first part! Towns and 3079 are great games though.
All three games actually seems worthy of support. For 10£, it's a fair trade I think :)


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Chopin: Piano Concertos Nos. 1 & 2 / Tamas Vasary; Ivo Pogorelich, pianists
1 CD / Deutsche Grammophon / 2012-10-09Works: Frédéric Chopin: Concerto for Piano no 1 in E minor, B 53/Op. 11; Concerto for Piano no 2 in F minor, B 43/Op. 21
Performers: Pogorelich, Ivo [Piano]; Vasary, Tamas
Conductors: Semkow, Jerzy; Abbado, Claudio
Ensemble: Berlin Philharmonic; Chicago Symphony Orchestra
Iconic recordings from the most legendary classical artists in history. The Virtuoso Series brings back many of these cherished titles back into the forefront at...continue...
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UEFA has banned vuvuzelas from matches at all UEFA competitions. That includes the European Championships, the Europa League, and the UEFA Champions League.
My first reaction was: "That's rather ignorant and authoritarian." But then I realized that I had a bigger gripe. UEFA's decision to ban vuvuzelas in European competition sets a very strange precedent. Continue reading


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The agency overseeing Waterfront Park has warned the state it has the legal power to approve a design for an overpass at the Great Lawn.
The Waterfront Development Corp. wasn't pleased with two early designs the state proposed for a wider stretch of Interstate 64 traversing the lawn as part of the Ohio River bridges project.
Waterfront officials prefer a span that has the least impact on the lawn -- like the one the state has rejected and didn't release publicly. That design would require the fewest pillars but probably would cost more than the other two. ...


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This Kaoko Throttle Control is designed to fit all 7/8" bar bikes with aluminum handguards.
Give your wrist a rest! The Kaoko throttle control greatly reduces rider fatigue and
hand/wrist strain. The vibration dampening benefit reduces hand numbness. Rider
can remove hand from throttle grip while cruising… throttle opening will remain
as set. It's simple to operate, even with heavy winter gloves.
Installation is easy, with less than 15 minutes to fit stock grips; a bit longer
for aftermarket grips. High quality, compact and durable design, super smooth
Kaoko Cruise Controls are to be used only by experienced and
responsible riders.
Note: Use
the cruise control for its designed purpose: cruising when
it is safe to do so. At all other times disengage it. Use of cruise control is
at the sole risk of the rider and by the rider's decision to use it he/she does
indemnify the manufacturers or organizers, their agents, employees and officers
against any claim or action by themselves, their dependants or any other third
party arising out of any loss, damage, injury or death suffered as a result of it's use.


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Jennifer Aniston is so fetch!
The actress, 45, is in talks to star in the upcoming comedy Mean Moms, multiple sources tell E! News. The movie is an adaptation of Rosalind Wiseman's book Queen Bee Moms and King Pin Dads: Dealing With the Parents, Teachers, Coaches, and Counselors Who Can Make—or Break—Your Child's Future. Wiseman also wrote the book Queen Bees and Wannabes, which inspired the 2004 movie Mean Girls.
Similar to Mean Girls, Mean Moms will focus on a newcomer who struggles to find common ground with her suburban neighbors, whose sole purpose seems to be one-upping each other's parenting.
Beth McCarthy-Miller, who recently directed The Sound of Music Live, is set to direct the comedy. Adam Shankman, Jennifer Gibgot and Jill Messick are producing the project for New Line.
Though Aniston played up her girl-next-door persona during Friends in the '90s and early '00s, she's found success in recent years with edgy box office comedies like Horrible Bosses and We're the Millers. She'll next be seen on the big screen in Squirrels to the Nuts, Horrible Bosses 2 and Life of Crime.
News of Aniston's Mean Moms negotiations was first reported by The Wrap.


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A recent military family summit on Capitol Hill made clear that military families need and want more time to connect with decision-makers.
The summit was hosted by Reps. Cathy McMorris Rodgers, R-Wash., and Sanford Bishop, D-Ga., co-chairs of the Congressional Military Family Caucus. During separate 75-minute breakout sessions, which focused on children's issues, spouses' issues, service members' issues and veterans' issues, officials were peppered with a steady stream of questions.
In the crowded spouses' session, which focused on employment, education and child care, spouses talked about persistent difficulty getting federal jobs; the perceived reluctance of employers to hire mobile military spouses; problems transferring credits between educational institutions after relocations; difficulties in transferring licenses when moving out of state; insufficient child care and inconsistencies in service policies.
Issues discussed in other breakout sessions ranged from the need for better data collection about military kids' academic achievement to problems accessing specialty health care for special-needs children to the need for standardization of programs among the services to make it easier for families who are not near their service's installation.
A recurring issue is the lack of awareness about programs among service members and family members who need them. Attendees also called for better coordination of military and civilian programs that can help troops and their families.
A Marine captain said he felt the summit was "rushed," with too many scheduled topics shortchanging the discussions. He said attendees were told they were there to express their concerns to leaders, but felt they were getting some "pushback."
But Bishop and others, including Rob Gordon, deputy assistant defense secretary for military and community family policy, said feedback from troops and families about what is important to them is critical as leaders make decisions about budget cuts.
Gordon said the summit was important as a way to start a conversation between families and decision makers in an environment where people can be open and honest about raising issues. Now, Gordon said, it's time to take the questions and concerns back "to the respective leadership to start to address the issues."
He urged families to "connect back" to hold officials accountable in following up.
"We've heard some stories today that need to be fixed in our military community," he said. "If they're having those issues, it means others are having those issues, as well."
We'll be checking back, too.
firstname.lastname@example.com?subject=Question from ArmyTimes.com reader">Karen Jowers is the wife of a Navy retiree.
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Davis Art Center (DAC). The DAC offers classes to all ages and is an integral part of the local art community. A couple of days before I had been to a fun 'Arty Party' at the DAC, and I had also drawn the Center for a series of cards they will be selling at their annual Holiday Sale at the end of November. I wanted to give it another go, in panoramic form, and this took me a little over two hours, give or take a sandwich. November in Davis is an explosion of autumnal colour.Davis CA: Recently we held another of our monthly 'Let's Draw Davis' sketchcrawls at Community Park in north Davis, on a cold-ish but sunny and colourful November Sunday. I chose to draw another panorama, of the
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November 20, 2012
the autumnal art center
1 comment :
- TIA said...
Hi pete, long time no see! instantly recognise the post without looking at the name. lovely sketch.
- November 21, 2012 at 8:32 PM
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text:
Table 1
|Search strategy used in PUBMED
|Search (probiotic* OR prebiotic*) AND (infant formula* OR infant feeding OR formula OR formula milk) AND (preterm or premature or low birth weight babies) AND (randomized controlled trial* OR controlled clinical trial* OR random allocation*) Limits: Human
|Search (probiotic* infant formula* OR prebiotic* infant formula* OR prebiotic* OR probiotic*) AND (infant formula* OR infant feeding) AND (premature OR preterm) AND (randomized controlled trial* OR controlled clinical trial OR random allocation* OR double blind method OR single-blind method OR clinical trial OR placebo* OR random* OR research design OR comparative study OR follow-up studies OR prospectiv* OR volunteer* OR control* (singl* OR doubl* OR trebl* OR tripl*) NEAR (blind* OR mask*) Limits: Human
Mugambi et al.
Mugambi et al. Nutrition Journal 2012 11:58 doi:10.1186/1475-2891-11-58


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- Filed Under
Walton's Trick or Treat hours are tonight from 6-8 p.m. There is the Christian Church Trunk and Treat from 6-8 p.m. This is a safe celebration on the church parking lot. Includes contest for the truck or car trunk decoration, games, food, drink and goodies.
The Walton-Verona Boys and Girls Basketball teams are sponsoring a multi-family yard sale and craft sale at the Walton Verona Sports Complex in Verona on Nov. 2. If you would like to participate and sell some unwanted items of any type, contact Tom Luebbe at tom.luebbe2kyschools.us or call 859-322-0487 to rent a space. You keep 100 percent of the proceeds you make, just pay the rental space fee. The event will be well advertised to help our teams and you.
If you would like to help stock the Senior Citizens Pantry at the Community Center this month through December, there are boxes at Walton City Hall. There is a need for the easy open cans of soups, tuna , spam, single serving boxes of oats and cream of wheat. Small bags of sugar, flour and artificial sweetener would be appreciated.
Lila Stansbury of Sarasota, Fla., has been visiting her mother, Dortha Black of Bedinger this week.
Leonard "Lenny" Whalen, a good friend and neighbor has accepted the position as superintendent of Dawson Springs, Ky., Independent School District. Lenny has been a life-time resident and we will certainly miss him and his family. But wishes for a successful future are extended to him. Lenny has served as deputy superintendent for Gallatin County school system for the past eight years. Lenny's wife Kelly has served as secretary of Walton Verona High School for several years and her services will be missed. Good luck to Lenny, Kelly and their two children Taylor and Addison.
Ruth Crowe Davison of Sun city, Calif., one of Walton Verona High School graduates of 1951, comes back to her home state each year to visit her family and friends. This year was a very special occasion; she was observing her 80th birthday. Ruth's sister Ora and her husband George Scott of Independence decided to surprise her with a birthday party. With the help of family members including her sister Shirley Stoneberg and husband Jay of Los Angeles, a beautiful buffet was served to classmates, friends and family on . 28. The celebration continued on with the 1951 class's monthly get together on Oct. 1 at the Our Best Restaurant in Smithfield, Ky., where 21 class members and guests extended their best wishes for her birthday on Oct. 20.
Walton's Christmas Home Decorating Contest will be judged on Dec. 3. There will be a dividing line at Old Beaver Road designating north and south entries. Call City Hall 859-485-4383 before 5 p.m. on Dec. 2 to enter. There will cash prizes awarded.
We will be honoring our veterans with a special service at the Walton Verona Veterans Memorial on Nov. 11. We will have a schedule of the program next week. The Boone County Historical Society will be honoring our veterans on Saturday, Nov. 9, at the Boone County Historical Society Museum in Burlington with their annual veterans exhibit. If you have any memorabilia, photographs, uniforms that you would like to loan and share, please call Betsy Conrad - 859-371-5882; Pat Yannarella - 859-835-2435; or Virginia Lainhart at 859-689-7240.


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NEW YORK (CNNMoney) - JPMorgan, the nation's largest bank by assets, said Tuesday it is replacing 2 million credit and debit cards after a massive breach at Target.
As many as 110 million Target customers were impacted by the hack, including 40 million customers who used credit and debit cards over 19 days at the peak of the holiday shopping season. Luxury retailer Neiman Marcus said it, too, was breached, and experts say they wouldn't be surprised if other companies were also hit.
JPMorgan Chase CEO Jamie Dimon, in a call with financial analysts after the company posted its fourth-quarter profit, disclosed the card replacement.
He called cybersecurity "a big deal," and said banks, retailers and transaction processors "really have to put an extreme effort into protecting" their operations.
But the hack hasn't stopped customers from using credit and debit cards, he said. Consumer spending via plastic is down "just a little bit relating to Target, but not in general," Dimon said.


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Sonoma's City Council showed little support Monday night for reviewing the city's policies on consuming alcohol in public to deal with unruly behavior at city-sponsored events.
Mayor Joanne Sanders sparked the discussion by requesting that the city review police issues stemming from this year's Fourth of July celebration, which drew as many as 10,000 people to Sonoma and included problems with people drinking too much.
Police Chief Bret Sackett, in a memo to City Manager Linda Kelly, said the council may want to review the city's alcohol policies to curtail future problems.
Alcohol consumption is permitted in most of Sonoma's public places from 11:30 a.m. until dusk, unless extensions are granted.
Most council members said they saw no need to change the policy.
"I'm not in favor of having a few buttheads dictate how we go about our business," Councilman Ken Brown said.
Sackett reported that police made 13 arrests during this year's Fourth of July event and officers resorted to using force in four of them.
In his report, he attributed the unruly behavior to large crowds, warm weather and Sonoma's "liberal alcohol laws" and wrote that officers could have taken more people to jail on suspicion of public intoxication if the Police Department not been stretched so thin.
Several council members appeared surprised at Sackett telling them Monday night that people can possess and consume alcohol while walking Sonoma's streets, at least during hours when it is permitted.
People are not allowed to take alcohol out of bars or restaurants, however.


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I Love Life Profiles
Posted: August 13, 2014|
The Herald's I Love Life campaign is a year-long project to change lifestyles in Plymouth, focusing on eating, drinking, smoking, weight and mental wellbeing. Today we introduce you to our magnificent seven I Love Life readers who are each hoping to make healthy changes to their lives
OVER the next two months The Herald will follow seven people as they embark on the I Love Life programme.
Our seven readers will be learning how to change one or more aspect of their lifestyles which will make a huge difference to their everyday lives.
The campaign, run by The Herald in partnership with Plymouth City Council, brings together organisations from across the city which are dedicated to improving the health of local people.
Related content
Plymouth Community Healthcare, Plymouth Community Homes and the University of St Mark and St John are all also involved in the campaign to help make a real difference to people's lives.
The seven people taking part in the campaign range from retired servicemen, full-time drivers and professionals to mothers of new-born babies.
Over the course of the next two months they will take part in seminars run by Plymouth Community Healthcare professionals on topics covering healthy diet, knowing their alcohol limits, tips for positive mental health, and hidden fats and sugars in food labelling.
The group will also take part in weekly sessions at the University of St Mark and St John to help improve their lifestyle.
Steve Waite, chief executive of Plymouth Community Healthcare, said: "Plymouth Community Healthcare is delighted to support the new I Love Life campaign.
"We already have an excellent track record of providing the care and welfare that people need in their homes, and in our local health facilities.
"Our focus for this I Love Life campaign is very much on promoting well-being, and we specifically want to help people to stop smoking, become more active, and eat more healthily.
"Through our Livewell team we will be offering practical and easy-to-follow health tips on how to make a real difference to people's daily lives."
The Herald will follow the progress of all seven I Love Lifers throughout the eight weeks of their programme.
Kayleigh Wilks
KAYLEIGH is 26 and weighs 18½ stone. With a body mass index of 43 she is classed as clinically obese and has tried many times to lose weight without success – but she hopes the Love Life campaign will be different.
She said: "I've always found losing weight to be a real struggle. I have polycystic ovaries and it's made losing the weight very hard for me. The weight has given me a lot of other health issues; I suffer from depression, back pain and anxiety about going outside.
"Sometimes I look in the mirror and I just think 'Oh God!' It really gets me down and I just think everyone must be looking at me.
"I've tried quite a few weight loss plans. I went to the 10 Per Cent Club but was turned down because I was told I had to lose more than 10 per cent of my weight. I've even tried things like the baby food diet and had tablets from the doctor, but none of it has worked."
Kayleigh believes her weight gain is linked to the smoking habit she managed to quit two years ago.
"I started gaining weight when I quit smoking. I stopped completely when I became pregnant with my daughter because I wanted to have a healthy pregnancy.
"I quit smoking for the first time when I was 18 and I was on and off cigarettes until 2 years ago when I quit completely."
"I believe the depression and anxiety would go if I could lose the weight. They're all linked. People don't realise it's actually physically painful to walk. The walk down my road is only two minutes and I struggle to make it."
"I attend a breastfeeding class every week and two baby groups a week – I'm not actually breast-feeding any more but I go to socialise with people. I don't leave the house much and it's nice to meet people at these groups.
Despite her polycystic ovaries Kayleigh's pregnancy was very easy for her; "The pregnancy itself was actually really simple – my back pain improved and my weight levelled out.
"After I gave birth I just went right back to where I was. My little girl is 13 months old now, and she definitely keeps me busy. We have a one-bedroom flat, so there's a lot to keep tidy in a small space."
"I thought about buying a juicer to help me lose weight but I can't afford one; £30 might not seem like a lot to some people, but it's a lot for me."
Now a size 22 and struggling to find suitable clothing shops, Kayleigh is hoping to get back to her former size of 14.
; "My goal is to get to a size 14; right now I'm a 22 and it's so difficult to find clothes for my size. I really want to be able to go into a shop and buy normal clothes! When I was 12 years old I was a size 12 and I've been a 22 for 3 years now - I just really want to get rid of the weight."
Helen West
HELEN has just completed the 10 per cent weight management course run by Plymouth Community Healthcare and is determined to look nice at her 40th birthday in October.
The 10 Per Cent Club is delivered in targeted neighbourhoods and forms part of Plymouth Community Healthcare's Health Improvement Team. It focuses on helping individuals to make small lifestyle changes which can have a large effect on their health.
Helen joined when she weighed 15st 8lbs – and now weighs 12st 13lbs. She said: "Being part of the club was good, as it was nice to know everyone in the group was there doing it all together."
Helen plans to celebrate her birthday in a dress she feels comfortable in. She said: "Since January I have lost two stone and five pounds. I want to lose another three stone by October – but to have a healthy body mass index I have to lose three and a half stone."
Plymouth Community Healthcare works with people across the city in a number of ways, including trying to make them more active. It was the same for Helen.
She said: "I do a lot of walking and am training to take part in the St Luke's Midnight Walk, which is in three weeks' time. I also go on my exercise bike as much as I can. I walk to and from work, and about six miles each day at work. I work in a nursing home so this involves a lot of time being on my feet."
For many the hardest part of losing weight is giving up the things we crave. Helen's downfall was chocolate, which she has found hard to give up.
"I have cut out sugar, crisps and fizzy drinks," she said. "I love my chocolate, and it has been really hard to not eat that. I am a comfort eater and would just come home and eat whole bars of chocolate. My husband is a chef, so he has been cooking extra lean stuff for me."
Helen's two children, aged 15 and 18, have helped her by changing their regular annual gifts.
"Instead of buying me chocolate and wine for Mother's Day this year they bought me flowers," Helen said.
Being part of the 10 per cent, free 12 week programme has helped Helen lose weight as she has had others to do it with. The 10 per cent programme is aimed at adults 16 plus, with a BMI between 26-35 who are in good health and motivated to make changes around their current lifestyle.
Helen said: "I haven't joined the gym but am just trying to do as much exercise in my own time as I can. I have tried dieting before but never really stuck at it - now my husband can support me because he is trying to lose weight too.
"At the moment I am quite happy where I am - I haven't been this size since before I had my two children."
As part of The Herald's I Love Life campaign we will be tracking Helen's progress over the coming months.


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onsdag, november 30, 2011
On my merry way...
Finally I am on my merry way as far as the "merry" knitted squares are concerned. But it has been such uphill work. Every time these knitted squares have made an appearance in my blog (and it has been a few!) I have received several questions about their assembly. To which I had no answer.
After having finished all the squares, and having stared at them for weeks on end, I finally took the plunge and started stitching them together. Just like I had done with the grey blanket (crocheting them together, maybe with a contrasting colour, was discarded after some time´s contemplation).
I do find it difficult to get a neat result. Stitching the vertical seams is easier, as I can always use a matching colour. But the horizontal seams are worse. I have been told that if an exact colour for stitching is not available, use grey. In this instance I considered light blue to be the next best thing...
I still find the stitching uphill work, but I do like the finished look so far, so continue I shall... merrily! I would love to get this finished by Christmas, but from where I stand it does not look promising. I shall keep you posted.
(The lovely roses in these photos were given to me by my lovely hubby on my lovely day yesterday).
Lagt inn av Mia kl. 3.12 p.m. 12 kommentarer: Linker til dette innlegget
mandag, november 28, 2011
Volume III
About one and a half years ago I very nearly closed my blog. But before doing so I had my blog printed out as a blog book. Which turned out to be two whole books (after then 3,5 years of blogging).
A while back my blog had its 5th anniversary, and I thought it was about time to order my 3rd book. And so I did. The book took some time to come, but here it is... Volume III of the saga of Mias Landliv!
I am sure Mias Landliv will one day cease to exist (at least online... unless, as an old biddy, I will continue to blog about the goings on in the old people´s home... Somehow I doubt it!). But with these books Mias Landliv will not be completely gone, and I will have a lasting memory, a diary really, of all these blog years.
I have ordered my books from Blog2print. If you order your book before the 30th of November you get a 15% discount. My "Volume III" is a hardcover book, has 270 pages and cost about $106, including shipping.
Lagt inn av Mia kl. 2.12 p.m. 29 kommentarer: Linker til dette innlegget
fredag, november 25, 2011
When in Paris...
When in Paris it really is impossible not to make a stop at Galeries Lafayette, all decked out in her Christmas finery. Quite impressive, quite festive.
When in Paris you really have to have some chocolate... And of course we could not resist all the pretty packaging, with all the sweet stuff. A few treats to our friend and family, and some for ourselves for Christmas.
When in Paris you really have to have some macarons, and we could not leave the place without bringing some home with us. Macarons seem to be the rage in Bloglandia, and now I know why.
No Paris without lovely lotions and potions. I am partial to L´Occitane products, and even though they are widely available all over the world it still was tempting to bring some home from Paris. Also, I found a new perfume to love, Diamonds by Armani (Italian, I know...)
My love of books is not exactly a well hidden secret, and yet again I found it hard to resist a lovely French decorating book by Michéle Lalande. The French do it just so well, don´t they?
I have several books by the same author, and even though most of them are in French, I do enjoy the lovely photographs (even though most of the time the writing is incomprehensible).
So where did we stay in Paris, you might wonder? I can heartily recommend this little boutique hotel nearby the Opera. Most of the delectable shops and sights are within walking distance from this hotel. And we did walk...
We stayed on the top floor, in an attic room. It was indeed a lovely room to return to after a log day out and about the streets of Paris. And more often than not, we indulged in a lovely restorative bath before re-venturing the streets of Paris.
But one of the best things about this lovely room was the little balcony and the view of the rooftops of Paris, basking in the morning sun. I do hope to return, both to Paris and to this delightful hotel, one day.
Meanwhile, I do want to remind you of the Basnes Christmas Fair, starting as of tomorrow.
Lagt inn av Mia kl. 9.46 p.m. 7 kommentarer: Linker til dette innlegget
torsdag, november 24, 2011
Paris love
The reason for my recent silence is... Paris! As it happens yours truly has a special day this month, one that my loved ones thought reason enough to celebrate.
So taken quite unawares, I was literally swept off my feet and flown off to Paris, to celebrate that very special day.
Now I have been to Paris only once, way back in my youth... more years ago than I care to remember. But Paris stayed in my mind as one of those places I would love to return to. And now I have.
Paris was at her best behavior and welcomed me (or so I thought) with sun, bright blue skies and pleasant temperatures.
I did many of the touristy things expected of one; Eiffel Tower, Notre-Dame, Latin Quarter, Sacré-Coeur, Montmartre... you name it.
And I loved it all. In fact, I love Paris, and can hardly wait to return. In the mean time I better brush up on my French, which at the moment is limited to merci, bon jour, au revoir, bon soiree and the like...
Next time I will show you where we stayed (right by the Opera), and what I brought home from Paris...
Lagt inn av Mia kl. 10.57 p.m. 23 kommentarer: Linker til dette innlegget
onsdag, november 16, 2011
Things tend to move forward slowly for me, it seems. Craft wise, I mean. I am always eager to start a new project, often forgetting that I already have several others on the go. But the temptation to start a new one is hard to resist, and more often than not I give in.
As has been the case with my latest crochet. I started it a while back, but lost interest, and left it lying in the basket with the wool. Until the other day, that is, when I once again picked it up and set to work, quite liking what I saw (if I may say so).
Something else (without any comparison) I found lying about the other day, when I emptied the compost bin, were these bulbs. There, under layers of composted garden debris, I discovered them. I have no idea what kind of bulbs they are. And how they ended up in the compost bin is anybody´s guess...
As for my crochet, it is about to come to another halt, as I am running out of wool. Something that was bound to happen, I guess, since I initially started it with wool left over from other projects. But there never is enough left over wool, is there? Not even for a cushion cover...
Lagt inn av Mia kl. 3.32 p.m. 17 kommentarer: Linker til dette innlegget
mandag, november 14, 2011
The mellow fruitfulness is long gone but the mists seem to prevail, as this November has proved to be particularly misty. I do not mind, as I quite like the mysterious atmosphere the mists create.
Not that there is anything remotely mysterious about my activities of late... I have been quite busy in the garden, preparing it for the approaching winter. And if I may say so, I am quite pleased with the results.
The compost has been emptied and spread over the raised beds for soil improvement, making it a real feast for the hens (all the juicy earth worms...) Not that the compost is the only place for such delicacies...
The currant bushes have been pruned (I am afraid it is ages since it was last done). A bonfire is planned for tomorrow, to burn all the cuttings. I can hardly wait for the lovely wood smoke in the misty air.
All the flower beds, in the potager and elsewhere, have been cut back and cleared (I task I often fail to do before the snow falls) and they are about as ready for winter as can be.
And so am I, even though I would not mind if the misty weather continued a bit longer. I quite enjoy it and love to be outdoors this late in the year. As do the hens... a hen party in the mist.
Lagt inn av Mia kl. 5.31 p.m. 17 kommentarer: Linker til dette innlegget
torsdag, november 10, 2011
Xmas workshop
Some of you regular readers might remember I was a bit of a busy bee last autumn, making stuff for a Christmas Fair. And some of you have asked whether there will be a fair this year too.
The answer is yes. There will be a new Christmas Fair at Basnes, and I will have some stuff there this year too. Christmas stockings, for one.
So it is about time to get cracking. I have set up a little Christmas workshop in my studio. This is the outcome so far. A pair of stockings in the making, utilizing old lace, ribbon and some such.
Another pair is also on the go, making use of snippets and small scraps of fabric. Mostly in blue and white (with a bit of Cath and GreenGate thrown in for good measure).
These stockings are such fun to make. A bit of candle light and some Christmas music to set the mood, and time just flies, making it almost hard to leave my little studio at the end of the day.
(Despite my previous resistance, I seem to be getting into all things Christmassy...)
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tirsdag, november 08, 2011
This year I thought I would be prepared. Two years ago I collected some green moss in early November for my Christmas decorations, while last year winter set in unseasonably early, leaving me no choice but to buy imported green moss from Denmark. Quite embarrassing really since green moss is plentiful in the woods just behind our house!
Even though I so far have refused to think about Christmas just yet, it does not hurt to be prepared, right...? So in the lovely sunny afternoon sun (the first we have seen of the said sun this November) I took a little stroll, basket under my arm, into the woods. The mild weather was just about as far removed from any nostalgic idea of a white Christmas as can be, yet I could not help but start thinking a little bit about the coming festive season.
Yesterday I bought the first hyacinth bulbs. Now for us in Scandinavia hyacinth really is a Christmas flower, and not a spring bulb, like in many other countries. Hyacinths also happen to be my very favourite Christmas flower (along with amaryllis). So with the hyacinths and the green moss I think it is safe to say that I have indeed started some tentative Holiday planning.
This year I am thinking rustic. I do not usually go to great lengths to decorate for Christmas. For me the most important thing is the tree (no Christmas without one), together with flowers and candles. Of course it is still early days, and things are subject to change...
Have you started planning your Christmas decorations?
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|I love most books<3
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My name is Olivia. I have an amazing girlfriend. Her name is Kaitlyn<3 She's super sweet and awesome. I love her to death. I love to write,sing,and draw. I dance some,but not tons. I'm a major grammar nazi. Grammar is a BIG part of life. I love to read and watch movies. Saw series is possibly my favorite. God bless<3
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How to set job rates
I am trying to start my own buisness. I am wondering how to estimate bids for various landscaping and mowing jobs. Also I am wondering how to set my mowing rates. Any help would be grateful. Thank you
What are you mowing? Commercial or Residential? First of all make sure you get all your licensing and insurance so then you are legit and then when you get your first call for a quote go and walk the property and see what the estimated size of the property is, for instance have a set price for an 1/4 acre and then 1/2 you get the idea. Now for the price, thats up to you. Obviously no one works for free, charge what you think you need to make in order to make a profit and cover your wear and tear on your equipment. For me I charge about 65$ for an acre, but im rasing it up to 75$ because as you get bigger your expenses get higher. 30$ and up for a normal city lot. I screwed my self in the beginning and gave a guy a quote for 45$ for an 1.14 acre lot. Its ok, it got me an additional 6 customers because he told everyone he knew that I did good work at a good price. But in the beginning you can't be trying to strike it rich on your first customers, hard work for less money than your competition when your starting out is the only way your going to land customers.
Thanks for the info. I am mowing both commercial and residential. There are alot of mowing companies where I am located. I know I dont want to lowball them, but I also want to be able to get the customers.
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Filed under: Promos & Exclusives,Steady Bootleggin',Tragedy Special
Written by: Robbie Ettelson
Taken from the Saga of A Hoodlum sessions – Tragedy over an unmixed K-Def track:
Tragedy – "Buck Buck"
22 Comments so far
Leave a comment
How good is K-Def?!?!
Does anyone know where I can get a CD of Willi Boo Boo? Failing that, a decent quality MP3 download of the album until I can find a CD?
Peace.Comment by Ross 02.12.07 @
These guys have it:Robbie 02.12.07 @
Good as anything i've heard from them! Another winner Robbie. Great job.Comment by bbatson 02.12.07 @
dope, killer cut. Trag needs to do a full-length with K-Def. When will Tarag's documentary drop..Comment by seedlessone 02.12.07 @
woahComment by noz 02.12.07 @
Hawkeye sent me to your gemsite, how about an exclusive from the dangerzone for your site? hit me on myspace.com/djtootuffComment by djtootuff 02.12.07 @
WOW – good work Robbie… theres a few tracks / alt versions thta didn't make it to the "Saga" LP, I would def like to see some of them get a release!
Dang. Nice hookup. THis is gonna get some spin this week. No question.Comment by bse 02.12.07 @
Dope Track…THX
Could you hook up an MP3 of this if possible Robbie?
peaceComment by stiefel 02.12.07 @
I agreed only to stream this one…Comment by Robbie 02.13.07 @
yo shout out to djtootuff… Much respect to you.
Hop on that offer Robbie.Comment by bbatson 02.13.07 @
what's k-def?real drum breaks and those little details alias loops/samples…but exactly these "little details" makes his productions so damn' awesome!BIG!
"buck buck" is the typyical k-def style.in the 90's no other beatmaker ruled the art better than k-def!
what mo can i say?!Comment by mario 02.13.07 @
'Back then it was so crazy. Premo, Xtra P, Pete Rock and RZA – those four dudes were sampling breaks that I had all the breaks. Like "One Love" break…I had all those breaks before they used it, they just were sitting there.'
i would think it was before, thats why it was unreleased?Comment by western 02.14.07 @
Dope as fuck.Comment by Big Paul Castellano 02.24.07 @
yo the link died, could u repost it by any chance?Comment by genetix 03.02.08 @
Leave a comment
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Now in its 12th year, the Forty Under 40 program puts the spotlight on Uta...Read More
Happy Together
Living Well
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Tool Up
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Sequestration Shockwaves
Lessons Learned
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Going to Pot
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Building and Construction
Moving Up
Gail Miller: Stepping into the Spotlight
Around Utah
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UB Voices
The Secret to Effective E-Commerce Strategy and Keeping Customers Happy
The economists at Zillow, Inc., which operates the largest home-related marketplace on mobile and the web, predict Salt Lake City will have the hottest residential real estate market in the country for 2014, ahead of metros like Seattle, Austin, San Jose and Miami.
Dave Anderton thinks the Zillow prediction is a year late.
"2013 was our best year in seven years," says Anderton, communications director at the Salt Lake Board of Realtors. "But the national ranking tells you we are in a good place now."
That's not to say 2014 won't be a great year for real estate, but realtors think in terms of home prices and units sold—and in those two areas, 2013 was an incredible year. Utah experienced a 13 percent jump in the median price of a home and a whopping 35,253 units sold statewide.
"That's the best it's been for units sold since 2006," adds Cal Musselman, president of the Utah Association of Realtors. "That's a lot of units sold. It's good for the state; it's good for the real estate market and for the economy."
Market Shock
Overall, Utah experienced a 10-percent increase in units sold over 2012. In Salt Lake County, home values jumped 15 percent while home sales for all housing types jumped 9 percent. The spring of 2013 saw a home buying frenzy in some Utah markets, with multiple buyers in bidding wars for the same properties. It was a crazy time, with interest rates in the 3 percent range, low home prices and extremely low inventory.
"People had to hurry if they were going to get in the home they wanted," says Anderton. "And when the sellers saw they were getting three and four offers for their properties, they thought, 'If the demand is this high, I am going to raise my prices.' Word got out that the market was back and prices went up."
Musselman says there was also some "buyer's shock" that accompanied the frenzy because buyers wanted to offer 10-20 percent less than sellers were asking.
"In reality, if their offers were more than 3 percent less than the asking price, they would miss out," he says. "It was a bit of a shock to realize they had to dance to the tune of the sellers after being in a buyer's market for two and a half years."
Hitting the Brakes
The market settled down as the year progressed, but remained strong across the state for most of the year. The greatest weaknesses were in the rural areas of the state still trying to recover from the economic woes of the recession, while the hottest markets were in Summit and Washington counties.
Utah was on pace to hit 40,000 units sold, but sales dropped off in the third quarter of 2013.
A seasonal decline is typical, but Anderton believes the decline could be the start of a trend. "October was the first month we saw a drop in the number of units sold on a year-over-year basis," he says. "It was the first month we had seen a decrease in almost two and a half years."
Anderton blames the decline in units sold in the last quarter on the price gains the market experienced over the past 18 months. "Prices came crazy back, especially in 2013, to where they are almost overpriced now," he says. "The surge priced some people out of the market. Now, sales are falling off but prices have remained high and interest rates have gone up." He notes that inventory has increased as well.
Musselman says the increase in inventory is a good side effect of the increase in home values. "We will see more sellers come off the sidelines now that values have increased and there is enough equity in their homes to make a move upwards."
However, the combination of interest rates in the 4.5 percent range (which is still a great rate, say the realtors), more inventory on the market and home prices that are $30,000 to $40,000 more than they were six months ago may be causing buyers to take a breather.
"They are saying, 'Hey, I'm going to take my time, I am not going to jump in and buy right now,'" says Anderton.
Finding Balance
The median home price for all housing types statewide was $205,000 in 2013, up 13 percent compared to $182,000 in 2012. In Salt Lake County, the median home value is about $225,000. Anderton says about 75 percent of the homes in the county sell below $300,000 and when home prices push above the $300,000 threshold it prices the average family out of the market.
"The median household income in Utah is about $60,000. When you get home prices pushing above $300,000, people just can't qualify for a loan under today's mortgage guidelines," he says. "Utahns have big families and prices can only go up so much before you price them right out of the market."
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Two weeks ago my wife and I were trying to cut up some very large logs that were in our front yard (we are senior citizens) when suddenly a gentleman drove up and asked if he could help. Well, he took out his large chainsaw and immediatly started sawing it all up into log lengths. When he was finished we offered him some money but he would take nothing, just that he wanted to help. Well, it helped greatly and we wanted to thank him. So there are still good people left in this world. So thank you Mr. Kelly Waltner.


text:
A LaTeX 2.09 package that defines a spacing environment which you can use anywhere in your document.
This package should no longer be used: it has serious bugs, and is no longer maintained. It is superseded by setspace.
The author is Stephen Page. The package is Copyright © 1986 Stephen Page.
License: lppl Version dated: 2008-10-31 Catalogued: 2015-08-03


text:
Approve disaster aid
House Speaker John Boehner has taken his lumps. His delay in bringing the Senate's entire Sandy relief bill to the floor at the close of the 112th Congress — and his subsequent promise to make it the first order of business for the 113th — could leave struggling fishermen the ones battered and bruised.
The $51 billion in storm aid Boehner slated for debate on Jan. 15 had $150 million for fisheries disaster relief. It had been passed by the Senate, but Boehner reportedly thought he'd asked too much already of his party by helping to push through the Biden-McConnell-negotiated Senate bill at the edge of the "fiscal cliff." Asking for a vote on a spending bill just after raising taxes might not be politically expedient, he feared.
But in late December, New York and New Jersey politicians — including some of Boehner's colleagues in the House — let the vitriol fly. By the next day, Boehner had promised everyone a quick vote on $9 billion for the National Flood Insurance Program that can go to storm victims and a Jan. 15 vote on the rest of the original $60 billion bill.
By the end of that week, Boehner had been re-elected as speaker of the House, and all the bad blood had ebbed away, a lot faster than Sandy's waters left New York and New Jersey.
With the immediate aid accomplished, House members now have the opportunity to apply scrutiny to the details of the remainder of the bill.
We anticipate that Massachusetts' representatives will continue to speak up about the necessity of the fishing aid, a mere three-tenths of 1 percent of the $50 billion bill. Reps. William Keating and John Tierney displayed their sense of priority and timing by immediately vowing to work quickly to bring aid to those who need it.
House Oversight Committee Chairman Darrell Issa, R-Calif., was supportive of Boehner's delay, noting on "Fox and Friends" that the bill had been just about doubled in size thanks to "pork" jammed in by New York's Democratic senators.
"They had the opportunity to have a 27 to 30 billion-dollar legit relief package, packed it with pork, then dared us not to vote on it," he said. The pork Issa refers to appears to be relief for those who haven't yet recovered from Hurricane Isaac and in the red states of Alabama, Mississippi, Texas and Louisiana.
Exercising due diligence is hardly ever an offense, and Boehner's move to push the vote to this week will allow that. There should be no way, however, for the House to conclude that disaster relief for fisheries somehow constitutes "pork." We hope, also, that the right-leaning members of the House of Representatives remember that disasters and disaster relief don't exist only on paper. We hope they see things the way Keating and Tierney do, that is, that delaying relief to millions of people is relief denied to individuals a million times over.


text:
|Cochlear neuronal populations in developmental defects of the inner ear. Implications for cochlear implantation.
MedLine Citation:
|PMID: 3156467 Owner: NLM Status: MEDLINE
|A histological study was made to determine the cochlear neuronal populations of 20 human ears having hearing loss caused by developmental defects. The neuronal populations ranged from 7677 in an ear with Mondini dysplasia to 30 753 in an ear with DiGeorge's syndrome, the norm for young human subjects being 35 000 neurons. The length of the cochlear (spiral) ganglion varied from 7.3 mm to 14.8 mm, the norm for human subjects being 12 mm. The sensorineural hearing losses in all cases were attributable to malformation or degeneration of the sensorineural structures. The hearing loss was moderate in one case of Alport's syndrome, severe in one case of Usher's syndrome and in one case of severe Mondini dysplasia; it was profound in one case of maternal rubella, one of congenital deafness of unknown cause, another case of severe Mondini dysplasia and one of Down's syndrome (Trisomy 21). One case of mild Mondini dysplasia and one of DiGeorge's syndrome were known to have normal hearing. In 4 other cases hearing status was absent.
|J M Schmidt
Related Documents :
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Publication Detail:
|Type: Journal Article
Journal Detail:
|Title: Acta oto-laryngologica Volume: 99 ISSN: 0001-6489 ISO Abbreviation: Acta Otolaryngol. Publication Date: 1985 Jan-Feb
Date Detail:
|Created Date: 1985-04-02 Completed Date: 1985-04-02 Revised Date: 2007-11-15
Medline Journal Info:
|Nlm Unique ID: 0370354 Medline TA: Acta Otolaryngol Country: SWEDEN
Other Details:
|Languages: eng Pagination: 14-20 Citation Subset: IM
Export Citation:
|APA/MLA Format Download EndNote Download BibTex
|MeSH Terms
Cell Count
Child, Preschool
Cochlea / abnormalities, cytology*
Cochlear Implants*
Deafness / congenital*, pathology
DiGeorge Syndrome / pathology
Down Syndrome / pathology
Hair Cells, Auditory / cytology
Infant, Newborn
Klippel-Feil Syndrome / pathology
Middle Aged
Nephritis, Hereditary / pathology
Neurons / cytology
Organ of Corti / abnormalities
Retinitis Pigmentosa / pathology
Rubella / congenital
Spiral Ganglion / cytology*
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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Next Document: Budd-Chiari syndrome treated by percutaneous transluminal angioplasty. Report of a case.


text:
- 2 cups all-purpose flour
- 2 teaspoons baking powder
- 2 teaspoons sugar
- 1/2 teaspoon salt
- 2 cups buttermilk, plus more for thinning
- 1 large egg, beaten
- 1 tablespoon vegetable oil, plus about 1/4 cup for the pan
- 4 ounces (1 stick) unsalted butter, cut into teaspoons
- Orange Syrup
- Powdered sugar
- Into a large bowl, sift together the flour, baking powder, sugar, and salt. Add the buttermilk, the egg, and 1 tablespoon of oil, and stir just until blended, being careful not to over mix. (Lumps are okay.) Let the batter stand, covered, in the refrigerator, for at least 1 hour, and up to 8 hours. If necessary, thin with extra buttermilk after resting.
- Preheat a large, heavy skillet or griddle over medium-high heat. Add enough oil to lightly grease and leave a film on the bottom of the pan.
- Working in batches, ladle the batter about 1/2 cup at a time into the pan. Cook until golden brown and bubbles start to form on the top, about 2 minutes per side. Transfer to a platter and cover to keep warm.
- To serve, divide the pancakes into stacks among 4 plates. Pour syrup over each stack and sprinkle with powdered sugar and pass the butter at the table. Serve immediately.
Recipe Details
- Source: Emeril Live EM1E75e
- Dish Type: Entree
Similar Recipes
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Orange Syrup
Oranges With Red Wine Syrup And Orange Pound Cake
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Duck, Andouille, And Scallion Pancakes With Ginger Orange Sauce
Duck, Andouille, And Scallion Pancakes With Ginger Orange Sauce


text:
Helen Holmes / Courtesy
A helicopter search has turned up no new information in the search for a Townshend woman who has been missing for more than a week, the Vermont State Police said Monday.
A search by the Customs and Border Protection air and marine unit Saturday covered the Jamaica and Townshend areas looking for Helen Holmes, 59, but the effort was unsuccessful, state police spokeswoman Stephanie Dasaro said.
Holmess whereabouts remain unknown.
Have we looked in other places? Yes, Dasaro said. For the air search, just because we dont have any specific information that identifies that shes at this place or she had her phone pinged here, those places are the closest to where she lives, so thats where they started their aerial search.
Police describe Holmes as 5 feet 6 inches tall and weighing 150 pounds with blonde hair. The authorities have said they believe she is driving a red 2010 Subaru Forester with Vermont registration DAK316.
Holmes was last seen at 9 a.m. Sept. 6 at her home on Plumb Road, and she was reported missing after she failed to make a scheduled appointment at 2 p.m. that day.
Police will continue to monitor Holmes cellphone, social media and financial activity and interview people who could shed some light on her location, Dasaro said, adding that no activity has been seen on those platforms so far. As of Monday afternoon, police reported no indication of foul play but said they remain concerned for Holmes safety.
Our job at this point is to really focus on the details that we have and continue to look at any investigative leads and continue to interview and go over all the information that we have in hopes that were able to locate Ms. Holmes, Dasaro said.
Anyone with information about Holmes or who has had any contact with her is asked to call the state police at 254-2382 or send an anonymous tip by texting CRIMES (274637) with keyword VTIPS, or online at http://vsp.vermont.gov/tipsubmit.
Contact Elizabeth Murray at 651-4835 or email@example.com. Follow her on Twitter at www.twitter.com/LizMurraySMC.


text:
A thread known by it's friends as "Back when Elite was a noob" or Bwewan for short was enjoying a brisk walk in OTD when suddenly a wild Shianova came out of nowhere with an axe and struck it down where it stood!
Bwewan was loved by many and it passing will be remembered but today I will see in that Shianova will pay for his crimes and hopefully all the threads OTD can once again no longer live in fear of the merciless thread killer.
[Edited by Elite, 7/13/2010 4:18:49 AM]
i'll be the jury
No, you won't. I am both judge and jury and I hereby call on Shianova to hear his side of the story. If he does not appear by 20:00 Coordinated Universal Time he will be henceforth deemed as guilty and sentenced to 25 years in a maximum security facility of the plaintiff's choice.


text:
"this hobby is supposed to be fun. When it stops being fun, check yourself, because you're doing it wrong." Charles Cowdery
Passed on a 4R 1B CS, but I may very well go back today and pick it up, if it's a recipe I don't have.
I passed on a few things today. A lot of Handy. I'm glad it's still out there because if I get in a bind I can always drink that. Also, I passed on more BTAC things, a 2011 Stagg, ER(didn't look for the date), PHC 27, rittenhouse 23, vintage 17 21 23, weller sr older bottlings w age statement, ORVW 10 90 & a lot of Willetts.
Btw, I passed on a 2 yo willett rye that I was curious about. Has anyone had this and how does it compare to the 4yo or the 5yo. I love the the 4 yo and the 2 yo has a proof that is higher than the 5yo which is why I'm curious. Any idea?
Last edited by jeanraulmitchell; 07-18-2012 at 10:55.
"A man comes from the dust and in the dust he will end-- In the meantime it is good to drink whiskey."
Passed on a Weller's Original from 1913. A little out of my price range.
Last edited by BFerguson; 07-18-2012 at 18:09.
"Life is life and fun is fun, but it's all so quiet when the goldfish die."
Belle Meade bourbon has found its way to Atlanta. Had to look it up...
I'm guessing this is HH make. $34.99. Passed.
[one of 'em looks kinda like Ashton Kutcher]


text:
Task Force recommends screening adolescents for clinical depression
Research Activities, May 2009, No. 345
The U.S. Preventive Services Task Force now recommends screening adolescents for clinical depression only when appropriate systems are in place to ensure accurate diagnosis, treatment, and followup care. This applies to all adolescents 12 to 18 years of age. In a separate recommendation, the Task Force found insufficient evidence to assess the balance of benefits and harms of screening children 7 to 11 years of age for clinical depression.
The Task Force reviewed new evidence on the benefits and harms of screening children and adolescents for clinical depression, the accuracy of screening tests administered in the primary care setting, and the benefits and risks of treating clinical depression using psychotherapy and/or medications in patients 7 to 18 years of age. Their conclusions are based on a report from a research team led by Selvi Williams, M.D., at the Kaiser Permanente Center for Health Research, which is part of AHRQ's Oregon Evidence-based Practice Center.
Clinical depression is an important cause of poor health and lower quality of life among children and adolescents. Depression can cause difficulties in school and disruptions of family and social relationships as well as diminished quality of life. Children and adolescents with depression are at an increased risk of suicide, which is the third leading cause of death among people aged 15 to 24 and the sixth leading cause of death among those aged 5 to 14. Adolescents suffering from clinical depression are also more likely to suffer from depression in early adulthood.
There is adequate evidence that treating adolescents with selective serotonin reuptake inhibitors (SSRIs), psychotherapy, or combined therapy (SSRIs and psychotherapy) results in decreased clinical depression symptoms. Treating clinically depressed youths with SSRIs is associated with an increased risk of suicidality (suicidal thoughts, preparation, and attempts of suicide) and, therefore, should only be considered if careful clinical supervision is possible.
See "Screening and treatment for major depressive disorder in children and adolescents: US Preventive Services Task Force Recommendation Statement," by Ned Calonge, M.D., M.P.H., Diana B. Petitti, M.D., M.P.H., Thomas G. DeWitt, M.D., and others in the April 2009 Pediatrics 123(4), pp. 1223-1228.
Editor's Note: The Task Force is the leading independent panel of experts in prevention and primary care. The Task Force, which is supported by the Agency for Healthcare Research and Quality, conducts rigorous, impartial assessments of the scientific evidence for the effectiveness of a broad range of clinical preventive services, including screening, counseling, and preventive medications. Its recommendations are considered the gold standard for clinical preventive services. The recommendations and materials for clinicians for these and previous Task Force recommendations are available on the AHRQ Web site at http://www.ahrq.gov/professionals/clinicians-providers/guidelines-recommendations/uspstfix.html. Clinical information is also available from AHRQ's National Guideline Clearinghouse™ at http://www.guideline.gov.