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Dating to 17th century England, piqué is an antique technique used to ornament items of tortoise shell, mother-of-pearl or ivory with a fine patterned inlay of gold or silver. With their love of natural materials, the Victorians incorporated piqué into their repertoire of jewelry.
Two-part construction allows this bangle to effortlessly wear with its black elastic interior expansion and contraction. Deep brown natural tortoise shell is the medium which is inlaid with a wide band of silver flanked by two narrow stripes of gold placed along the center of the bracelet. Emanating from that central band is gold inlay reminiscent of a Gothic inspired trellis or choir screen. Buttery smooth on the interior, the bracelet is a pleasure to own as well as to wear.
Date: Circa 1870.


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You could make the case that this is the most important game of the season, and not just because it'll represent about a 4 percent shift in the playoff odds report. With three weeks until the trading deadline, both teams are trying to figure out who they are and what they need. There's a big difference between a team four games ahead and a team four games behind -- one of those teams goes out and trades for a Matt Holliday or a Chad Qualls, while the other sits on its prospects and wishes on next year. Tonight's game between two teams tied for first place kicks off the next three weeks. The next three weeks are everything.
To win the West: 52 percent
To win the Wild Card: 2 percent
To make the playoffs: 54 percent
(Based on one million simulations of the season from this point forward.)

subset: commoncrawl


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Yeah Bf they are awesome live. They put on a show, and while not having the most difficult stuff to throw out, they play it perfectly. I really enjoyed this album, but I've grown off of this and I like the older days of Days of the Pheonix
The first time I heard this album the whole way through I was not right in the head, and this sounded absolutely perfect.
Still sounds nearly there.
Album Rating: 5.0 | Sound OffThis is my favorite album ever. Sputnik's categorization of AFI as pop-punk is bordering on blasphemous.
Album Rating: 4.5AFI is pop-punk though
Album Rating: 5.0 | Sound OffNo they are not they are classic punk or punk revivalists. They have nothing at all to do with the modern pop-punk movement.
They're pop punk. Don't get all defensive. Maybe they're older stuff was more 'punk' but they still fit under this category. And your last sentence is pretty much wrong.This Message Edited On 02.06.07
Album Rating: 5.0 | Sound OffWell I guess it depends upon if you consider this album to be a total departure from their old sound, which even you admit was definitely punk. I still don't find even their new stuff to be in any way pop-punk. That's like calling Rush Metal or calling Death Cab for Cutie Emo. (both of which I have heard)
And I'm not at all defensive, I'm simply arguing my point. :-) *peace*
Album Rating: 4.3They kinda went from a vaguely hardcore-ish band into some sort of weird goth punkish thing to pop-punk now. Don't get offended, they're lumped in with The Red Jumpsuit Apparatus now. Always a good thing.q
Album Rating: 5.0 | Sound Off*sigh* I still see no relation between Decemberunderground and something like FOB, Paramore, or The All American Rejects.
Since I despise the Apparatuses with a burning passion, I'm afraid the band which holds my undying musical allegiance getting lumped in with them is something taht would offend me lol.
I wouldn't call decemberunderground pop-punk in some normal sense. It's it's own breed of pop-punk. It's pop-punk, yes, but in the All Time Low, Fall Out Boy, Say Anything sense.
Album Rating: 4.5Decemberunderground is most definitely pop-punk, in the exact same vein as FOB and Paramore and AAR.
Also it's a piece of shit.
I don't see it.
Album Rating: 4.3For as "un-innovative" as pop punk is, it has plenty of diversity. Also depends on your interpretation on what it is exactly.
Album Rating: 5.0 | Sound OffI disagree about DU but taht's a whole different banana (I totally just made up that expression). I rather liked it, though not nearly as much as any of their previous albums.
At any rate I still don't see any relation between it and the aforementioned bands. AFI, even at their lowest point, still manage to be utterly unique IMO.
Album Rating: 5.0 | Sound OffYess someone re-categorized them as punk. I am pleased. I was rather embarassed that pop-punk was making up 32% of my album scores.
I'll probably regret posting this but oh well.
Album Rating: 3.0They are certainly more pop than punk now by a long shot.
Album Rating: 5.0 | Sound OffUgh I don't want to start that argument again...
Album Rating: 4.3This is why multiple genres were introduced on sputnik...
I have an idea: lets start that argument again.
Album Rating: 4.3They used to be a hardcore outfit, then they became a punk band, then they became a pop-punk group. Whats so difficult to comprehend about that?This Message Edited On 02.21.07
Bands: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z


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High Resolution Systems UDC-400High Resolution Systems announced the new UDC-400 universal device controller 8/22/2010 6:15 PM Eastern
High Resolution Systems UDC-400
Aug 22, 2010 10:15 PM
High Resolution Systems announced the new UDC-400 universal device controller, a software-based control platform that allows simple, cost-effective control of devices using IP (TCP/UDP) or serial (232/422/485) protocols. The UDC-400 is a fast, flexible cross-platform control solution tailored for a wide range of operators, not just programmers. The system's software can be used by itself or with the USB-connected UDC-400-M control panel which features 40 buttons that be assigned any commands for any device. It runs on Windows XP, Vista, and Windows 7 operating systems. Price: NA
Read more about this product at The Briefing Room
|High Resolution Systems' UDC-400 Shines at Microsoft Global Exchange (MGX)
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Allen Summit Backpack Polyester Mossy Oak Break-Up Infinity Camo
Product #: 534618 Allen #: 19263 UPC #: 026509192633
- Information
The Allen Summit Hydration Pack is perfect for those who want a hydration system with extra room for gear. The pack is hydration ready and holds up to a 2.5 liter bladder (hydration bladder not included). It features a padded back and shoulder straps with ventilation mesh for extra comfort. Other features include an elastic bungee cord system for carrying extra clothing and a jam pocket that is perfect for carrying a spotting scope.
Technical Information
Technical Information
- Waterproof polyester
- 17" x 10" x 4" main compartment
- 1,075 cubic inches of cargo space
Delivery Information
The total weight of the product, including the product's packaging as it sits on our shelf. Since some products ship directly from the Manufacturer, their weight may be unavailable. Because of variations in the manufacturing process, similar products may have differing weights. Unless the product is designated as "Ships Alone", Shipping Weight does not include the shipping box or packing materials associated with your order.
Product ships from MidwayUSA, separate from any other products on your order due to its size. Products that are Shipped Alone incur separate "Per Order" and "Per Pound" shipping charges.
Product is regulated by the US Department of Transportation (DOT) and cannot be shipped via USPS or air shipping methods. DOT-Regulated products must ship UPS Ground.
Product is restricted by shipping carriers and cannot be shipped to certain locations or via certain shipping methods.
Additional shipping charge for HazMat products. Carriers charge extra to ship packages with products they consider hazardous, such as reloading powder and primers.
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Our Variety of Treatments at The Landmark Spa
With over 40 treatments to choose from, treat yourself to our facials, body wraps, massages, hot stones, envelopments and ayurvedic inspired treatments from ESPA or VOYA. Your treatment will be a totally personalised experience and the ultimate in indulgence, leaving you feeling relaxed, energised and rebalanced. Plus, why not treat a loved-one and purchase one of our packages as a gift voucher.
Monday - Thursday : Off Peak
Friday - Sunday : Peak


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DISH Network Provides Your Favorite Local Channels
In Murfreesboro, Tennessee for FREE
Save more on TV service by signing up for DISH Network in Murfreesboro, Tennessee. Get the best value around with prices as low as $19.99/mo for 12 months when you sign up today. Along with the best value for a satellite TV package, you will also receive FREE installation, an additional $13 off for 12 months, and much more.
DISH Equipment in Murfreesboro, Tennessee is the Best
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The latest DVR from DISH Network, the Hopper, offers the most advanced technology in the DVR industry. Store more than 2000 recorded hours, skip commercials, record 6 shows at once and access a broad On Demand library. Plus, you still get all the standard DVR features you're already used to. Don't miss this opportunity to have the Hopper DVR for your DISH TV in Murfreesboro, Tennessee.
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And You'll Have the Best in Satellite TV
Right now is the perfect time to take advantage of the best DISH Network promotions in Murfreesboro, Tennessee. For a limited time, DISH is offering over 55+ channels, including locals, for an unheard of $19.99/mo for 12 months! Not only will you get an extremely affordable price on TV, but sign up today and you'll get FREE HD for 24 months, FREE professional installation, and FREE HD receivers for up to 3 TVs.
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Student Affairs staff are involved in many areas pertaining to students. Some of those areas include: residence life (on-campus, off-campus, married student, apartment, and summer workshops), career planning and placement, academic advising, university policies and procedures pertaining to students, disability services, testing, counseling, student government and activities, student publications, Native American cultural services, veterans services, TRiO/Student Support Services (POWER Center) dining services, and student health and wellness. The staff serves on several committees on behalf of students and because of their varied responsibilities, can help students with almost any type of problem. Questions should be directed to the Vice President for Student Affairs on the lower level of the Administration Building or the specific office providing the service.
Dr. Richard Jenkins,
Vice President for Student Affairs
Contact Information
Phone: (701) 858-3299


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Redefining Leadership
As a speaker and consultant, Charles Herrick brings his rich background in business, leadership, and sports to clients worldwide – clients who understand the ROI potential of investing in their management teams. From IBM management to CEO of companies with thousands of employees, Herrick is able to deliver training, mentoring, and leadership development programs based on real experience. His speaking engagements offer entertaining and life changing insights. They go far beyond the feel good, believe-in-yourself rhetoric so often given by motivational speakers, which almost everyone could write for themselves — and which no one ever remembers. The programs at Herrick Leadership are substantive, meaningful, and will ensure your company continues to grow and prosper in the years ahead.
"Charles was the energizing force behind the growth of our organization. Our entire leadership team is stronger today as a result of his contribution." > Carol Berg, PGA
Speaking Engagements
Having gone from the hallowed halls of IBM to the mud huts of East Africa, stopping along the way to run a coffee company and a couple of big IT firms and then competing internationally in the 400 meter dash, Charles Herrick has a lot of good stories and ideas to share. Author, Businessman, Relief Worker, and World-Class Athlete aren't often found in one person.
Developing Leaders
Can you have more powerful results from less "management"? The cost of management is one of a company's most expensive line item yet it is rarely viewed as a potential for greater ROI. Most companies could double the span of control of their individual managers. And they would produce better results amid higher morale. What's preventing that from happening right now?
Written Works
With a free flowing writing style that makes any topic interesting, Charles is uniquely qualified to write on a number of subjects. He also likes to travel alone to some of the roughest places on the planet. Thanks to modern technology, these books are available now, prior to release. Learn more about Charles books and travels.
Herrick Blog
Follow Charles as he discusses topics from good leadership skills to adventures in different places. Every month you can gain a little more insight into his world.


text: Vergara's Fiancé Tears Her Dress in Weird Brawl Nick Loeb was thrown out of Miami club, sources say By Evann Gastaldo, Newser Staff Posted Jan 1, 2013 3:56 PM CST STORY COMMENTS (17) (Newser) – Sounds like Sofia Vergara didn't have a great New Year's Eve: In the wee hours today, she got in a fight with her fiance Nick Loeb at a Miami nightclub, and Loeb ended up getting kicked out. Sources tell the New York Post the Florida businessman got upset when Vergara took a picture with someone, and "started screaming at her." There was "some pushing and shoving" and Loeb eventually "had to be pulled off Sofia by security," a witness says. The Modern Family actress' dress was torn, and four security guards threw Loeb out, with Vergara following him. Sofia Vergara, star of ABC's hit comedy "Modern Family," looks on as her fiance, Republican businessman Nick Loeb, right, speaks during a news conference, Thursday, Nov. 17, 2011 in Miami Beach, Fla. (AP Photo/Wilfredo Lee) Actress Sofia Vergara, right, and Nick Loeb arrive at the Fifth Annual CNN Heroes: All-Star Tribute in Los Angeles on Sunday, Dec. 11, 2011. (AP Photo/Dan Steinberg) ADVERTISEMENT(Click Prev or Next to continue viewing images.) « Prev« Prev | Next »Next » Slideshow New York Post (Source Grid ») Celebrity entertainment • celebrity • nightclub • Sofia Vergara • Nick Loeb CLICK BELOW TO VOTE 19% 3% 10% 4% 7% 56% RETURN TO THE STORY To report an error on this story, notify our editors.


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- Filed Under
The Somerset County Business Partnership Technology Special Interest Group (Tech-SIG) will offer the business community the opportunity to participate from the comfort of their business in a conference call focused on Disaster Recovery and Business Continuity Best practices and lessons learned during Sandy.
The call is scheduled for Tuesday, January 22 from 8 to 9 a.m. The call-in number is 567-314-9038 followed by the access code of 2012 1357#.
Moderated by members of the Tech-Sig committee, the call will focus on Information Technology (IT) disaster planning and ...


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Elbert-Palmer Elementary School
Public School | Grades PK-5 | Christina
Wilmington, DE 19801
(302) 429-4188
About This School
Elbert-Palmer Elementary School is located in Wilmington, DE and is one of 23 elementary schools in Christina School District. It is a public school that serves 325 students in grades PK-5. See Elbert-Palmer Elementary School's test results to learn more about school performance.
In 2011, Elbert-Palmer Elementary School had 14 students for every full-time equivalent teacher. The Delaware average is 14 students per full-time equivalent teacher.
In 2011, Elbert-Palmer Elementary School had 14 students for every full-time equivalent teacher. The Delaware average is 14 students per full-time equivalent teacher.
Student Ethnicity (2011)
Students (2011)
Students Per Teacher (2011)
Female/Male (2011)
48% 52%
Subsidized Lunch (2011)
District Spending (2010)
$13,988per student
See All Test Scores
Grade 2 Reading Performance
Delaware Student Testing Program (DSTP) Results
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Elbert-Palmer Elementary School Reviews
By a Parent on
The school needs to discipline students more than last year . Palmer is a nice school but its to much bulling .Bulling isn't prohibited its in the code of conduct parent have to read it but the rule don't apply like they should . Students get away with it.Especially on the bus. Staff and transportation drivers need to communicate more. NO BULLING ON THE BUS! NO BULLING IN SCHOOL! Overall the school is good I will gave this year one more try.
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SHEPHERDSVILLE – During the recession how many Bullitt Countians remain one hardship away from homelessness?
The Shepherd's Shelter provides services to assist with such hardships, though the needs continue to grow for both the organization and its clients.
Formed in 2001, Shepherd's Shelter supplies homeless and those near homelessness with food, shelter and supportive services while helping to plan and maintain renewed self-sufficiency. Shepherd's Shelter is a faith-based non-profit organization.
2009 Coaches' All-Bullitt County Football Team
Player of the Year: Jeremaie Bennett, Senior, Bullitt Central
OFFENSE (Position, height, weight, class, school)
OL Andrew Casey, 6-4, 255, SR., Central
OL Gus Thompson, 6-1, 250, JR., Central
OL Mason Kelly, 6-3, 311, SR., East
OL Logan Pruitt, 6-4, 242, SO., East
OL Duke Tomlinson, JR., North
OL John Lister, JR., North
WR Jordan Smith, 5-10, 150, JR., East
MOUNT WASHINGTON ee" Kindra Clark says she's just a small-town girl who enjoys being in local pageants because they are fun opportunities to build self confidence.
But the Miss Kentucky USA judges recently saw a special magic in 19-year-old Clark and named her Miss Kentucky 2010 Nov. 29 at the Norton Center for the Arts in Danville.
"It was a remarkable feeling. Words cannot describe how excited and nervous I was," she said.
SHEPHERDSVILLE - Seven spoke in favor and six were opposed.
But all spoke with passion Monday night as speakers tried to influence Shepherdsville City Council members who would vote on whether to allow the sale of alcohol by the drink on Sunday.
At the end of the hour-long discussion, the Shepherdsville City Council voted 4-2 to allow Sunday sales in establishments with 100 seats and has an average of 70 percent annually in food sales.
SHEPHERDSVILLE - The Bullitt County Grand Jury will be the next panel to hear allegations of murder against an 18-year-old Bullitt County man.
Bullitt District Judge Jennifer Porter sent the case against Samuel Daniel Harris to the grand jury and kept his bond at $1 million cash.
Harris is charged with the death of a four-month-old infant boy, Aiden.
MOUNT WASHINGTON - Coming off the emotional one-point loss to Pleasure Ridge Park in the Louisville Invitational Tournament, the Bullitt East Chargers had almost an entire week in the middle of the season to re-energize their batteries.
The time was obviously put the good use as the red and gold returned to the court last week and picked up a pair of wins in a 24-hour period.
FRANKFORT - One of the most lasting traditions in Kentucky history is the now-annual "State of the Commonwealth" speech that the governor gives in early January to the General Assembly and, thanks to KET, a statewide audience.
On Wednesday, Governor Steve Beshear kept that tradition alive with remarks that reflected recent successes the state has had - and the challenges we face in the next two years.
HILLVIEW - After a lengthy investigation, three individuals were charged with drug-related offenses on Wednesday afternoon.
Blaine French, director of the Bullitt County Drug Task Force, said another police agency contacted his office to give some information on a possible trafficking operation.
Several complaints had been received on the home located on Overdale Drive in Hillview.
After observation of the residence, French said a search warrant was obtained.
SHEPHERDSVILLE - The man many have referred to as the best modern day politician in Bullitt County won't have to worry about passing out business cards any longer.
Incumbent Danny Fackler won't be running for a fourth term as "your jailer."
Fackler, 58, announced last week that he would withdraw his name from the May 2010 primary. Fellow Democrat Larry Ethington is the only other person who has filed but Paul Watkins has announced plans to run as a Republican candidate.
With the end of his term his year, Fackler will wrap up 29 years with county government.
SHEPHERDSVILLE - A long-time member of county government is looking for another four-year term as magistrate.
Clifford "Buddy" Shepherd has filed for his third consecutive term as First District magistrate. Prior to his current tenure, Shepherd served Bullitt County as a deputy jailer, sheriff and magistrate.
"I know the county," said Shepherd, 76. "I know the people. And I know the roads."
Copyright © 2015
The Pioneer News Online is your source for local news, sports, events and information in Bullitt County and Shepherdsville, KY, and the surrounding area.


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Social Equity
Vital communities meet the needs of all of their citizens. They provide good schools, affordable housing, and the basic services that enable even the least affluent to live comfortably. A healthy society fosters a wide sense of individual responsibility for the community.
The 3 E's of sustainability demonstrate the interdependence of a community's economy, social equities, and environment, where the economy exists within a society, and both the economy and the society exist within the environment.
Copyright 2000. Maureen Hart. www.sustainablemeasures.com. Figures used with permission.


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A patch of new pumpkins for the 2013 haunting season.
Tale of the Big Blue Bunny
Mr. Bunny was a cheap little dollar store stuffed animal that was our oldest son's best friend growing up.
The little blue bunny was a tremendous source of comfort during doctor visits, thunderstorms and those days when it felt like the whole world was against you.
During the years Mr. Bunny lost an ear and had many "surgeries" leaving him pretty tattered and torn…but he remained Carter's best buddy.
In honor of Carter's High School Graduation we decided to build a large papier mache Mr. Bunny, complete with his array of odd stitching and single ear.
The Bunny was made from recycled cardboard that was assembled into a Mr. Bunny shape then covered with papier mache.
The project was a lot of fun and was greatly appreciated by our oldest son….everybody needs a Mr. Bunny in their life.
Zombie Gallery
Finished some new papier mache zombie which feature some pretty amazing textures considering they were created with everyday household materials such as paper towels, facial tissue and toilet paper.
"They're coming to get you Barbara!"
Etsy Shop Now Open
Son Of Buster
My entry for the HauntForum $20 Prop Challenge is a companion piece to my 2010 entry titled "Buster Gravesley."
Buster Gravesley had a son named Buster. Buster's son was a gnarly surfer dude head banging sort of guy, always on the look out for the perfect wave. Unfortunately Buster Jr. met his end in the jaws of a Great White Shark and joined his father in the afterlife where he still raises Hell every chance he gets and never misses an opportunity to break free from the confines of his rotting grave. Like father, like son …. Meet Son of Buster.
The Son of Buster Prop was built almost entirely from recycled materials and papier mache.
The prop features a mechanism which allows it to be manually operated. When operated the tombstone cracks in half revealing the Son of Buster creature lurking behind the tombstone.
This piece had to be created for under $20 dollars so the hardware choices were economical, if you plan on building this I would suggest using additional material resulting in a sturdier prop (such as larger hinges, etc.).
Son of Buster took approximately 30 hours to create over the course of a month. This was a fun build and there was a fair amount of experimentation and new techniques in regards to creating the head and the hands. The final prop stands about 3 ½ feet tall and is 2 feet wide.
Mighty Midland Mantis
Completed a 5 ½ foot tall praying mantis sculpture for the 2013 Summer Sculpture Series Downtown Midland.
The big guy will be delivered this week and all things considered it was a very fun project.
The "Mighty Midland Mantis" was constructed from ½ inch pieces of plywood that were designed to fit together using minimum hardware.
The project was very much like assembling a large wood puzzle.
The sculpture will be displayed in the downtown are of the city during June, July, August and September.
Forty Favorite Photos
Enjoy The Season
Black Gate Gallery
Posted a collection of photos from our Halloween 2012 display called "Black Gate."
You can view the entire gallery here.


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Northbound motorists on Highway 1 drive under the Salinas Road overpass Friday morning. The northbound lane was opened early this morning with the project north of Moss Landing scheduled to be completed by early 2013.
- Filed Under
The following is scheduled road closures and roadwork for Monterey County commuters, subject to change.
MontereyCountyPublic Works
-- Paso Hondo from Carmel Valley Road to the end: Detour in place indefinitely for Cal Am Water pipe installation. ...


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|Chemopreventive and anti-cancer properties of the aqueous extract of flowers of Butea monosperma.
MedLine Citation:
|PMID: 20307637 Owner: NLM Status: MEDLINE
|ETHNOPHARMACOLOGICAL RELEVANCE: Butea monosperma (Lam.) (Fabaceae) popularly known as 'flame of the forest' has been widely used in the traditional Indian medical system of 'Ayurveda' for the treatment of a variety of ailments including liver disorders. AIM OF THE STUDY: To evaluate the antioxidative, anti-inflammatory, hepatoprotective and anti-cancer activities of the aqueous extract of Butea monosperma flowers. MATERIALS AND METHODS: Dried flowers of Butea monosperma were extracted with water. The extract was tested for its anti-proliferative, pro-apoptotic and anti-carcinogenic effects in hepatoma cell lines. The chemopreventive and anti-angiogenic effects of the extract were evaluated by its daily oral administration in a HBV-related X15-myc mouse model of hepatocellular carcinoma (HCC). RESULTS: Treatment with the aqueous extract inhibited cell proliferation and accumulation of cells in G1 phase. This was accompanied by a marked reduction in the levels of activated Erk1/2 and SAPK/JNK and induction of apoptotic cell death. Oral administration of the extract in transgenic mice conferred hepatoprotection as is evident from normal serum ALT levels and improved liver histopathology and lowered serum VEGF level. CONCLUSIONS: The ability of aqueous extract of Butea monosperma flowers to impose growth arrest and trigger pro-apoptotic death in cell culture strongly correlated with its strong chemopreventive effect in vivo when given orally.
|Tenzin Choedon; Surendra Kumar Shukla; Vijay Kumar
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|Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-20
Journal Detail:
|Title: Journal of ethnopharmacology Volume: 129 ISSN: 1872-7573 ISO Abbreviation: J Ethnopharmacol Publication Date: 2010 May
Date Detail:
|Created Date: 2010-05-17 Completed Date: 2010-10-28 Revised Date: -
Medline Journal Info:
|Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: Ireland
Other Details:
|Languages: eng Pagination: 208-13 Citation Subset: IM
Copyright Information:
|Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
|International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.
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|APA/MLA Format Download EndNote Download BibTex
|MeSH Terms
Administration, Oral
Alanine Transaminase / blood
Anti-Inflammatory Agents / pharmacology, therapeutic use
Antineoplastic Agents, Phytogenic / pharmacology, therapeutic use*
Antioxidants / pharmacology, therapeutic use
Apoptosis / drug effects
Butea* / chemistry
Carcinoma, Hepatocellular / drug therapy*, metabolism, pathology
Cell Death / drug effects
Cell Line, Tumor
Cell Proliferation / drug effects*
Liver / drug effects, metabolism, pathology
Liver Neoplasms / drug therapy*, metabolism, pathology
Mice, Transgenic
Mitogen-Activated Protein Kinases / metabolism
Plant Extracts / pharmacology, therapeutic use*
Vascular Endothelial Growth Factor A / blood
Reg. No./Substance:
|0/Anti-Inflammatory Agents; 0/Antineoplastic Agents, Phytogenic; 0/Antioxidants; 0/Plant Extracts; 0/Vascular Endothelial Growth Factor A; EC 18.104.22.168/Alanine Transaminase; EC 220.127.116.11/Mitogen-Activated Protein Kinases
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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Comments Thread For: Tatli Defends Against Fana on December 7 in Espoo
WBA I/C lightweight champ Edis Tatli, 21-0, will defend the title against South African former double world champ Mzonke Fana, 32-6, December 7 in Espoo (Finland). Fana replaces Argentinian Matias Ezequiel Gomez, who wasn´t approved by the WBA as he has been fighting exclusively for Comision Mundial de Pugilismo and not for Federacion Argentina de Boxe. Fana, age 40, is probably not as good as he once was but still represents a tough challenge for the undefeated Finn. [Click Here To Read More]
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Pink Blossoms Resort
Cove House – 4 Bedroom House
Gather your friends, your family, (or just yourself) together and enjoy the largest of our accommodations. The Cove House is a four bedroom (3 bedrooms with one king bed and 1 bedroom with one queen bed) , two bath house with a large kitchen where you can all sit around and plan your days and nights in fabulous Ogunquit.
Walk outside and dine on your private patio, go to the heated pool, or bring your racquet and get in a game of tennis on our courts. If you would like a little indoor pool time just stroll down the street to our sister property The Grand Hotel. The Cove House is your home away from home with all of the conveniences you need for a relaxing, memorable vacation.
Rooms in the Cove House – 4 Bedroom House
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Guest Blogger: 15 Ways to Stop Stressing and Start Living by Jill Muehrcke
Juliana (Jill) Muehrcke is the award-winning author of many books and articles. Founder and editor of the international magazine Nonprofit World (snpo.org), she has studied at the University of Colorado and the University of Michigan and has a BA degree, specializing in English and psychology, from the University of Washington. Jill is listed in Who's Who (MarquisWhoswho.com). In her spare time, she enjoys teaching yoga and eating ethnic food. For many years, in several cities, including Seattle, Honolulu, and Madison, she has written restaurant reviews.
Her latest book is Waking Up Happy: A Handbook of Change with Memoirs of Recovery and Hope.
You can visit her website at www.WakingUpHappyBook.com.
Listen to Jill on the Joy Cardin Show at http://wpr.org/search/ideas_program_search.cfm?StartYear=3&keyword=muehrcke&x=0&y=0.
There are many reasons why you may want to change your life. If you're in a relationship that's diminishing rather than enhancing your best self, or if you're eating the wrong foods, hurting your body, or doing other self-destructive things, you know, deep inside, that you can't continue on that path. And as you pass through different phases in your life – as you become a parent, for example, or an empty-nester or a retiree – radical adjustments are necessary.
Changing your life isn't easy. It means learning to know yourself. It means creating yourself anew. Because you're both the sculptor and the stone, it's a wrenching task.
And yet every sculptor knows that the piece of art that's meant to be already exists: It's a matter of carving its essence from material that's already there. When asked how the granite bear came to be, the sculptor says, "I just cut away everything that wasn't a bear."
Everyone's life cries out for transformation. If you don't change and grow, you die: Bit by bit, day by day, your innermost soul dwindles and perishes. The cost of not continuing to grow is ultimately feeling half-dead.
You're the artist of your own life. All you need do is pick up the tools for change and begin to use them. Each false start is a carving crucial to the final piece of art, paving the way for you to sculpt your greatest creation: the beautiful self that lies within the stone.
Soothe Your Soul: 15 Ways to Stop Stressing and Start Living
By Jill Muehrcke
One secret to a full, joyous life is to have a toolbox of coping strategies to pull out whenever you start feeling stressed, overwhelmed, or anxious. Here are some tactics that others have found useful to soothe and renew themselves:
- As frequently as possible, perform a cyber cleansing. Turn everything off – cell phones, computers, everything – and bask in the silence.
2. Use all your senses in the out-of-doors. Look around you and absorb the colors and shadings. Listen to the sounds – birds singing, frogs croaking, wind whooshing through the trees, waves lapping the shore. Smell the scent of the earth after a storm. Hold a raindrop or snowflake on your tongue. Pick a radish straight from the garden and taste the essence of springtime. Feel the texture of the grass underfoot, the icy shock of a fresh stream on your toes. Watch the sky. During the daytime, see how the clouds move and change. At dusk and dawn, notice all the colors of the sky. At night, look at the stars and feel your connection to the universe. Always make time for sunrises and sunsets.
3. Find a form of meditation that works for you. Not all meditation requires you to sit quietly: Many physical arts, such as tai chi, aikido, and yoga, are based on spiritual grounding and being centered. Dancing and running are other examples of activities in which you can deliberately be in the moment, at one with your body and breath. The Dalai Lama has noted that the purpose of meditation is to make space in your brain to overturn old habits and learn new ones. In that sense, you're meditating when you read these words and practice new ways of viewing the world.
4. Keep in touch with people physically rather than virtually whenever you can. The crucial parts of communication – the real connections – occur face-to-face. Giving and receiving smiles produce pleasurable changes in the brain that don't happen through technology.
5. Practice single-tasking rather than multi-tasking. What we call multi-tasking is really task-switching. Rather than doing two things at once, our brain is shifting back and forth between tasks. We end up doing neither one as effectively as we could, and we add harmful stress to our lives.
6. Sing or chant, either alone or with a group. Or repeat a word silently to yourself (words that end in "m" or "n" will increase the relaxation response).
7. Do a reality check. If you can't stop worrying about something, cross-examine that worrisome thought as if you were in a courtroom. What evidence is there that what you're worrying about will really happen? What would an objective witness say about it? What might other people do in similar situations?
8. Notice your breathing. Count how many breaths (one inhale, one exhale) you take per minute. Try taking fewer, deeper breaths. Five to ten full breaths a minute is optimal, but don't force it. Accept your breathing as it is. Imagine it as an ocean wave caressing you. As you inhale, imagine breathing in serenity and peace. As you exhale, breathe out anxiety and worry.
9. Move your body. Aerobic exercise and weight lifting are great stress reducers. Sometimes a quick walk, swim, or bike ride is all you need to refocus your mind and relax your body.
10. Schedule 15 minutes a day as your worry time. All your fears, obsessions, and concerns need to fit into that time frame. Don't let yourself be anxious any other time of day or night. If something comes up, just tell yourself, "I'm putting that onto the list for my worry time."
11. Feel the feelings in your body. Speak them out loud (for example, "I feel tense and tight.") Don't judge your emotions and sensations. Just observe and breathe into them. Appreciate how much your body is capable of doing, how much pleasure it can give you, and how well it manages to get you where you want to go.
12. Limit TV time. Research shows that the more TV people watch, the more anxious and dissatisfied they are. Find less passive ways to fill your time.
13. Take a nap. Time spent sleeping and dreaming is never wasted. High-quality sleeping can help you change your brain chemistry, adding neurons and opening new pathways in your brain, while rejuvenating your body and spirit.
14. Visualize a serene spot. It could be an imaginary place by a mountain stream, in a forest clearing, or on a sandy beach. Or it could be an actual place where you've felt safe and comfortable, such as your grandmother's house when you were little, a favorite vacation spot, or your own bed. Keep that image in your mind so you can return to it whenever you face a stressful situation and want to relax yourself.
15. Practice just sitting still and being in the moment, taking gentle notice of your environment and your body. Remind yourself that rarely is anything so important that it needs to be done right now. Remember that you can't accomplish any of your goals if you don't take time to renew yourself.
These and many other tips are offered by the 30 people who tell their stories in my new book WAKING UP HAPPY: A HANDBOOK OF CHANGE WITH MEMOIRS OF RECOVERY AND HOPE (WakingUpHappyBook.com). As each storyteller learns lessons in their life, I add exercises that you can do yourself to create those same changes in your own life.
What do you find most useful when you're feeling stressed out? Share your stories and ideas at the Waking Up Happy website (WakingUpHappyBook.com). I look forward to hearing from you!


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9 Cheap Ways to Work Out at Home
Posted on 1/13/2015 10:38 EST
The beginning of a new year often means weight-loss resolutions and promises to stick to a budget. It can be hard to meet either goal, let alone both. A gym membership that goes unused continues to drain a bank account, and while you can always lace up a pair of new running shoes and head outside on a regular basis, some of us need more structure. Here, then, are several cheap approaches to at-home fitness.
Photo by Syda Productions/shutterstock
Pop in a DVD.You don't need thousand-dollar treadmills and weight machines to get a good full-body workout at home. Dumbbells or elastic bands do the job for resistance training, and a jump rope can help increase cardio performance. Once you've determined what type of training you want to start with, finding a realistic plan you can stick with is important. A workout DVD is one way to go, and Cheapism's guide to workout DVDs features several that cost $10 or less and receive many positive reviews.
Join a Community.Finding support, either online or off, is an important part of keeping a workout plan on track. Even with a program to guide individual exercise, teaming up is a motivational booster. Online communities such as Reddit's r/fitness, are also filled with thousands of fitness fanatics willing to share advice and support.
Vary Online Workouts.There are numerous downloadable ways to work your body. A notable option is Gorilla Workout, which provides a number of different exercises -- everything included for 99 cents. DailyBurn features a huge variety of workouts, from yoga to kettlebells, led by different personal trainers. Take note: there's a $12.95 per month fee after the 30-day free trial.
Turn Exercise into a Game.If you love video games and need a push to get off the couch, you'll find kindred spirits at Fitocracy, which has users record their workouts to complete quests and "level up". Another popular downloadable fitness game is Zombies, Run! which boasts more than 800,000 participants. The app turns a run into a survival adventure as players dodge zombies and stockpile supplies with each mile.
Exercise Fast and Furiously.The New York Times currently lists two free 7-minute workouts, both of which supposedly target the whole body. Another home workout option is Max Capacity Training. It's free, easy-to-use, and well suited for people who are short on time and don't stock any equipment. The fitness program entails 16 minutes a day, three days a week, for 12 weeks. The app clearly explains how each exercise is performed, serves as a timer for the workout, and can be used to track progress. To make the most of limited time, Max Capacity Training combines high-intensity interval training (HIIT) and bodyweight exercises that are progressively harder as each week goes by.
Pose On Demand.Some quick searching can lead you to numerous apps that provide everything from ab workouts to yoga classes. Yoga Studio, for example, charges just $4 to create a customized order of poses and also lets you choose from the 65 classes offered.
Try Personalized Online Training.For one-on-one support and advice, a personal trainer who can help improve almost any routine is key -- and often pricey. To keep costs down and the at-home fitness program theme going, consider an online personal trainer. Although the trainer won't be able to move your body into the proper position, the expert can help create custom workouts and diets, define goals, and keep you committed. JWW Fitness offers private sessions via Skype, with prices depending on how many sessions you sign up for.
Work Out or Pay Up.If you really need a kick in the pants to maintain an at-home fitness program, several services link hard-earned money with working out. Pact is an app that tracks workouts at the gym, at home, or with imported data from running apps and fitness trackers. The catch is that you must hand over your credit card information and agree to work out a set number of times each week. If you don't follow through, you pay at least $5 for a missed workout; if you do keep up, you earn a share of the penalties paid by the laggards. Pact also lets you wager on how many fruits and vegetables you eat each week.
Weigh Your Wager.Although some people exercise solely for the purpose of becoming more fit, weight loss is typically a big motivator. DietBet users place a bet, typically $25 to $35, on whether they'll be able to lose 4 percent of their weight in four weeks or 10 percent in six months. After the time is up, users who hit the mark get to split the pot leftover from those who didn't meet the goal.
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MADD Kentucky is moving.
A few days after the biggest partying night of the year, New Year's Eve, MADD will move its state headquarters from Harrodsburg to Frankfort.
The organization - with a mission to stop drunken driving, support victims of DUI crashes and prevent underage drinking - will occupy five offices in the new Charity Suites building in Prevention Park for nonprofit groups. The building is owned by developer C. Michael Davenport.
"In Frankfort, we'll be closer to legislators, we'll have easier access to state government, and we'll be closer to people who can help us as we try to help them," said Frieda Cox, who served on a committee to find office space in Frankfort.
"That includes our partners in highway safety, the state Justice Cabinet and Victim Services, the Attorney General's Office, the Department for Mental Health, Substance Abuse, and the Alcoholic Beverage Control," said Sara McKinney, chairwoman for MADD Kentucky. "In Frankfort, we will also be closer to major media outlets. And from a business standpoint, it will give us a better pool of employees when we're hiring someone."
For more on this story, see today's State Journal.


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Panelist Biographies
James C. Barrow is an Investigator in the Drug Discovery Division of the Lieber Institute and an Associate Professor of Pharmacology at Johns Hopkins University. Dr. Barrow leads the medicinal chemistry, biology, and drug metabolism activities of the Lieber Institute Drug Discovery Division, with the goal of validating novel mechanisms and advancing treatments for disorders of brain development. He received his PhD from Harvard University, working with Professor David A. Evans and then moved to Merck Research Laboratories. Dr. Barrow worked on drug discovery projects for cardiovascular and central nervous system disorders. His team advanced several compounds into clinical development, including MK-8998, which was investigated in phase two clinical trials as a potential antipsychotic. Dr. Barrow is an author on more than 40 publications and an inventor with 19 issued patents.
Diane Bild is a Senior Program Officer in the Clinical Effectiveness Research program at PCORI. The program supports research that compares the effectiveness and safety of alternative healthcare options to enable patients and providers to make informed healthcare decisions. Dr. Bild has almost 30 years of experience supporting and conducting research in chronic disease epidemiology and prevention. She joined PCORI from the National Heart, Lung and Blood Institute at the National Institutes of Health (NIH), where she oversaw a program of research in cardiovascular epidemiology, prevention trials and health services research. Prior to that, she was a medical officer at the Centers for Disease Control in the Division of Diabetes Control, where she focused on macrovascular complications of diabetes. Her professional interests and research topics include cardiovascular disease epidemiology and prevention, subclinical cardiovascular disease, ethnicity and disease and diabetes. She has authored more than 80 publications in these areas. She received her bachelor's degree from the University of Illinois at Champaign-Urbana, her MD from the University of Illinois in Chicago, and her MPH in epidemiology at the University of Michigan. She trained in internal medicine at the Medical College of Wisconsin in Milwaukee.
Kenneth G. Carson earned a PhD from Cornell University under the guidance of Bruce Ganem. He then joined LeukoSite, Inc. where he worked on several inflammation-related projects such as integrin antagonists and chemokine receptor antagonists and contributed to nomination of several compounds for development (most notably CCR1 antagonists). In 2004, Dr. Carson joined Lexicon Pharmaceuticals to lead immunology chemistry. During this time, the team discovered sphingosine-1-phosphate lyase inhibitor LX2931, which entered clinical studies for rheumatoid arthritis. In 2007, he rose to Vice President of Medicinal Chemistry and took over the leadership of the medicinal chemistry group at Lexicon. His group has nominated multiple programs for clinical development in a variety of therapeutic areas.
Wayne E. Childers is Associate Professor of Pharmaceutical Sciences at the Temple University School of Pharmacy and Associate Director of the Moulder Center for Drug Discovery Research. He earned his PhD in organic chemistry from the University of Georgia in 1984, followed by a post-doctoral fellowship in bio-organic chemistry in the Department of Pharmacology at Johns Hopkins School of Medicine. Over the next 23 years at Wyeth Research he worked as a medicinal chemist on several drug discovery projects including anxiety, depression, stroke, Alzheimer's disease and neuropathic pain. He served as a team leader on four projects that advanced candidates to clinical trials. In 2010, Dr. Childers joined Temple, where he helped establish the Moulder Center, a fully enabled academic drug discovery center that combines the efficiency, teamwork-based business model and state-of-the-art technology with the innovation of academia. He and his colleagues are currently pursuing drug discovery projects with a number of academic and industrial collaborators in cancer, Alzheimer's disease, infectious disease, metabolic disorders, hyperlipidemia and PET/SPECT imaging ligand design.
E. LaBrent Chrite is the Dean of the School of Business and a Professor of Management and International Business at Montclair State University. Prior to joining Montclair State, Dr. Chrite was the Gemelli Faculty Fellow and Associate Dean for graduate programs at the Eller College of Management at the University of Arizona. He also spent 14 years at the University of Michigan and was the director of the School's flagship research and outreach institute, the William Davidson Institute, focusing on the transformation of transition and emerging market economies. Dr. Chrite has been actively Moderators and Panelists involved in academic leadership, research, teaching and technical assistance engagements in emerging and transition markets around the world. He has worked extensively with business leaders, policy makers and entrepreneurs in an effort to harness the energy and the dynamism of the private sector toward the alleviation of poverty and the investment in human capital. He has led research and development projects in dozens of countries in sub Saharan Africa, the Middle East, Central Asia, Central and Eastern Europe and Russia. Dr. Chrite completed his undergraduate work at Michigan State University, his MS at the University of Missouri-Columbia and his PhD at the University of Michigan.
Robert M. Goldberg is Vice President and Co-Founder of the Center for Medicine in the Public Interest (www.cmpi.org), a non-profit organization that advocates for consumer access to medical innovation, better health information and personalized healthcare. He is also the founder of CMPI's Value of Medical Innovation initiative (valueofinnovation.org) that promotes MPI. Goldberg was Director of the Manhattan Institute's Center for Medical Progress and Chairman of its 21st-Century FDA Task Force that examined the impact of the FDA's Critical Path Initiative on drug development and personalized medicine. His academic research focuses on the value of personalized medicine and medical innovation to longevity, economic growth and Social Security. He is the author of Tabloid Medicine: How the Internet is Being Used To Hijack Medical Science for Fear and Profit (Kaplan, 2011). Dr. Goldberg received his PhD in Politics from Brandeis University in 1984, is a devoted Yankee fan, and father of two children, Sara, 28 and Zach, 24.
David Kimball is currently Associate Vice President for Interdisciplinary and Translational Science at Rutgers University's School of Pharmacy. The mission of his team is to build value in collaborative biomedical research at Rutgers to enable highly competitive grant applications, and to use molecular imaging technologies, chemical synthesis and other enabling technologies to support the successful growth of biomedical startups in the State of New Jersey. Prior to joining Rutgers in 2011, Dr. Kimball spent 30 years in the pharmaceutical and biotech industry in various capacities in drug discovery and development. Dr. Kimball spent 19 years at Bristol-Myers Squibb in cardiovascular research and as a Research Fellow in oncology drug discovery. He holds a PhD in Organic Chemistry/Chemical Biology from the State University of New York at Stony Brook.
Leslie Levin is Vice President of Health Quality Ontario's (HQO's) Evidence Development and Standards division, which provides an evidentiary platform for health-related policy and funding decision-making. Dr. Levin works closely with the leadership of the health system, academia, industry and with government. He was instrumental in creating the Ontario Health Technology Advisory Committee (OHTAC), which advises HQO and the Ministry of Health and Long-Term Care on the adoption of all non-drug health technologies including health system changes and more recently in creating the Excellence in Clinical Innovation and Technology Evaluation (EXCITE) program housed at MaRS. The EXCITE program provides pre-market evidence based assessment of new health technologies as a collaboration between industry and academia, government and the broader health system. Dr. Levin is a Professor in the Department of Medicine, University of Toronto, and is a senior consultant in medical oncology at the Princess Margaret Hospital. He was the recipient of the 2012 Excellence through Evidence award by the Canadian Health Services Research Foundation.
Gilbert J. L'Italien is Executive Director, Global Health Economics and Outcomes Research at Bristol-Myers Squibb. He earned his doctorate in Epidemiology/Biostatistics from the Boston University School of Public Health. Dr. L'Italien brings over 25 years of observational research experience to his role and has published and presented extensively in the clinical, pharmacoepidemiology and health outcomes fields. Dr. L'Italien is also Adjunct Assistant Professor at Yale University Medical School and Affiliated Faculty member for the Robert Wood Johnson Clinical Scholars Program at Yale. In 2013, he was a member of the team that participated in a EUnetHTA early (payor) dialogue in support of a rheumatoid arthritis drug currently in clinical development. In 2003, he received the Bristol-Myers Squibb Ondetti and Cushman Award for the creation of a database function unique to the pharmaceutical industry. In 2006, he received the Bristol-Myers Squibb Distinction Award for design and conduct of the first BMS comparative effectiveness trial (STAR) of antipsychotic treatments in schrizophrenia patients. He has served in an advisory capacity on several committees: AHRQ/ CERT, Green Park Collaborative, Tapestry, the Viral Hepatitis Action Coalition and The Multiple Sclerosis Outcome Assessments Consortium (M.S.OAC). Most recently, in collaboration with the CDC Foundation, Dr. L'Italien co-developed an economic model that contributed to a favorable recommendation by the USPTF on universal screening for Hepatitis C. Prior to joining BMS, he was the Director of Vascular Research at Massachusetts General Hospital and held a faculty appointment at Harvard Medical School Dr. L'Italien's current research interests focus on use of large scale databases for comparative effectiveness research, predictive modeling, and the application of prognostic and predictive biomarkers to clinical trial development and real world research. His policy goals focus on strengthening public/private partnerships to enhance patient centered research. As a volunteer researcher, he recently designed and led a public health intervention that effectively treated 3,000 indigenous adults and children in rural Mexico to ameliorate the burden of soil transmitted helminthes.
Andrew MacKnight is the Chief Strategy Officer at Coriell Institute. In this role, he is charged with supporting the Institute's business operations while also identifying opportunities for market expansion. Mr. MacKnight has expertise in business and market development and advances the Coriell mission by implementing strategic initiatives designed to stimulate operational growth, cultivating productive new partnerships, and assessing and optimizing best practices. Mr. MacKnight has held prominent leadership positions within the biopharmaceutical industry. He served as Vice President of Marketing for the clinical services company Covance and the Vice President of Strategic Marketing for Thermo Fisher Scientific, a leading life sciences company. In addition, he spent eight years with GlaxoSmithKline, ascending to the position of executive product director of U.S. vaccines, where he was responsible for the public health and vaccines policy team. Immediately prior to joining Coriell, Mr. MacKnight led strategy and integration operations at InVentiv Health Clinical, a leading global clinical research organization. Mr. MacKnight earned his degree in philosophy from the University of Glasgow in Scotland. Cheryl Maiello is the Associate Director/U.S. Team Lead Staffing, Global Development for Novartis Pharmaceuticals Corporation. She graduated from Montclair State University in 1997 with a degree in Communications. She was a member of the MSU Field Hockey Team and an honors member of Lambda Pi Eta. Mrs. Maiello has been with Novartis since 2008 supporting Global Development in staffing. Previously, she was with ImClone Systems and NPS Pharmaceuticals as a Senior Human Resources Generalist. She was co-chair for the Working Parents Connection Employee Resource Group for three years and active participant in other diversity and inclusion initiatives. Mrs. Maiello is the mother of two boys, ages eight and six.
Avinandan Mukherjee is Professor and Chair of the Marketing Department at the Montclair State University School of Business. Dr. Mukherjee is the Founding Editor-in-Chief of the Emerald journal – The International Journal of Pharmaceutical and Healthcare Marketing. This double-blind-reviewed scholarly research journal is dedicated to advancing theoretical and empirical understanding of marketing pharmaceutical products and healthcare services. Before joining Montclair State, Dr. Mukherjee was a full-time faculty member of Marketing at Pennsylvania State University, University of Bradford (UK), Nanyang Technological University (Singapore) and the Indian Institute of Management (India). He has a doctoral degree in Marketing from the Indian Institute of Management (Ahmedabad), and was a visiting doctoral scholar at the ESSEC Business School, France. He is an Electrical Engineer by background and has worked with ABB (a Fortune 500 company) as Marketing Manager. Dr. Mukherjee's research and teaching interests include healthcare services, patient compliance strategies, digital healthcare, and pharmaceutical marketing. He has published more than 75 research articles in journals and conference proceedings. He has also authored eight chapters in edited books, five case studies, and three popular articles. Dr. Mukherjee has worked as a consultant with several pharmaceutical and other companies across the world. Dr. Mukherjee's research and teaching interests include healthcare services, patient compliance strategies, digital healthcare, and pharmaceutical marketing. He has published more than 75 research articles in journals and conference proceedings. He has also authored eight chapters in edited books, five case studies, and three popular articles. Dr. Mukherjee has worked as a consultant with several pharmaceutical and other companies across the world. Moderators and Panelists
John C. O'Donnell is Vice President, Global Health Economics and Outcomes Research at Bristol-Myers Squibb. He leads a diverse global team of 55 scientists dedicated to defining, developing and delivering evidence of value to ensure patients, payers and providers have the best possible information about, and optimal access to medicines. Dr. O'Donnell is co-chair of the Worldwide Market Access Council at BMS with responsibility for ensuring appropriate reimbursement and market access considerations are incorporated throughout the development process within R&D. He is a member of Academy Health's Methods Council which seeks to develop strategies for professional development in Comparative Effectiveness and Health Services Research methods as well as identifying future needs in the areas of training, in best practices and in the development of new methods. Dr. O'Donnell is also an Institutional Council member of the International Society of Pharmacoeconomics and Outcomes Research and was lead author and editor of the Value in Health 2009 Special Issue: Health Technology Assessment in Evidence-Based Health Care Reimbursement Decisions Around the World: Lessons Learned. The supplement provided an assessment of established HTA bodies for those countries grappling with ways to manage expanding healthcare expenditures. Dr. O'Donnell received a PhD in Health Policy and Administration from the University of North Carolina at Chapel Hill. He has 20 years of experience in health services and outcomes research in industry, in academia and in U.S. State and Federal governments, with over 15 years of experience in the pharmaceutical industry. While in government and academia, he advanced health policy research in rehabilitation services, veterans' health and the aged through his work with the U.S. Department of Veterans Affairs and Duke University's Center for the Study of Aging and Human Development. He also analyzed optimal social service and primary care delivery models for foster care and geriatric team care. Dr. O'Donnell is Adjunct Professor at the University of North Carolina at Chapel Hill and Adjunct Senior Fellow at Duke University Medical Center for the Study of Aging and Human Development. He has published in the areas of health economic evaluation, health policy, health services research, geriatrics and rehabilitation and is a reviewer for leading journals including Medical Care, Value in Health and the Archives of Internal Medicine.
Ülo Palm is Senior Vice President of Drug Development and Research Operations at Forest Laboratories. Prior to this role, he was Vice President, Clinical Operations and Therapeutic Area Head of Respiratory Clinical Development. He is a member of the Operations Committee for TransCelerate BioPharma, Inc. (TCB), where he also leads the Future Initiatives workgroup looking at new project opportunities for TCB. Including Forest, Dr. Palm has 24 years of overall experience in the pharmaceutical industry with such organizations as Novartis, Schering-Plough and Bayer. He is a Senior Member of the American Society for Quality (ASQ), as well as being certified as a Manager of Quality and Organizational Excellence (ASQ-CMQ/OE). Dr. Palm is an MD and PhD, and also holds an MBA degree.
Heidi Pfefferkorn is currently U.S. Director of Process Excellence in the Novartis Pharmaceuticals Corporation, Technical Research & Development Quality Assurance Group. She is leading a team responsible for development of an application and associated processes for the monitoring of regulatory compliance of clinical trial supplies globally. Mrs. Pfefferkorn has worked at Novartis Pharmaceuticals Corporation for 20 years, holding positions with increasing responsibilities in different areas of drug development. Her experiences include positions in: Regulatory CMC: responsible for supporting large transfer projects in commercial production; Clinical Trial supplies: leading team responsible for supply design, packaging operations, warehouse and distribution operations; Global Project Management: responsible for coordinating all development activities across multiple line functions, including budget management; and Isotope Laboratory; responsible for synthesis and analysis of radiolabeled compounds used in various laboratory and human studies. Mrs. Pfefferkorn holds a BS in Chemistry from Montclair State University and an MS in Chemistry from University of Pennsylvania, with thesis advisor Nobel Laureate, Dr. Alan MacDiarmid.
David Rotella is Sokol Professor of Chemistry in the Department of Chemistry and Biochemistry at Montclair State University. He earned a PhD in medicinal chemistry from Ohio State University and carried out postdoctoral research in organic chemistry at Penn State University. Dr. Rotella joined the faculty at Montclair State University in 2011 after a successful 20-year career in the pharmaceutical industry. His current research is focused on discovering new lead compounds for use in parasitic, central nervous system and infectious diseases. Dr. Rotella has authored 30 scientific publications, holds seven patents and has presented at more than 30 invited lectures at U.S. universities since 1991 on drug discovery topics.
John Siekierka is Sokol Professor of Medicinal Chemistry and Director of the Margaret and Herman Sokol Institute for Pharmaceutical Life Sciences. Prior to joining Montclair State University in 2007, Dr. Siekierka was director of research and development at the Center for Biomaterials and Advanced Technologies (CBAT) at Johnson & Johnson where he directed research in drug device combination technologies. Dr. Siekierka also held positions as senior research fellow and Head of Immunosuppression Research at Johnson & Johnson Pharmaceutical Research and Development, L.L.C. as well as senior research positions at Merck Research Laboratories and the Roche Institute of Molecular Biology. Dr. Siekierka is a graduate of Seton Hall University (BS), City University of New York (MS) and New York University (PhD).
MaryLinda Schumann earned a BS degree in Chemistry and Biology as well as a master's degree in Chemistry from Montclair State University. She began her career in chemistry with a summer QC position at Andrew Jergen's the summer she graduated from high school and worked part time while matriculating towards her BS degree at a small water treatment company doing boiler water analysis. Upon graduation she began working for Oakite Products, Inc. (now Chemetall US) as an entry-level chemist formulating metalworking fluids. Mrs. Schumann has been at Chemetall for 35 years. After starting in formulations, she has been involved in many aspects of the business, including development, support (lab and phone), analytical and manufacturing from both a hands on and a management perspective. Mrs. Schumann has had the opportunity to be the recruiter for the company's internship program for the past nine years. On the personal side, she met her husband in her Chemistry class at Montclair State. They have two daughters; one is a Montclair State University graduate in Justice Studies and a paralegal. The other has an AAS Degree in Hospitality and is currently at Montclair State and will graduate in May 2014 with a degree in General Humanities.
Maria Webb is Chief Scientific Officer, Venenum Biodesign, and has worked in the pharmaceutical industry since 1989 when she joined Bristol-Myers Squibb to work in the Cardiovascular Pharmacology Department. Dr. Webb's lab focused on G-protein coupled receptors (GPCRs) where she and her team worked on several cardiovascular research projects that advanced to the clinic. At BMS, Dr. Webb became interested in the underlying role of inflammation in cardiovascular disease and started working on chemokine and cytokine biology and signaling. She worked for 12 years at Pharmacopeia, Inc., a pioneering company in ECLIPS and UHTS technology from 1996 to 2008. Dr. Webb and her team implemented this technology to discover hits for many disease relevant targets such as GPCRs, kinases, nuclear hormone receptors, ion channels, integrins and others. The technology platform was used in collaborations with Roche, Celgene, Schering-Plough, Organon, GlaxoSmithKline, Daiichi, Takeda, BMS, Wyeth, Pharmacia and Upjohn, Biovitrum, Otsuka, and Kowa among others. Pharmacopeia's discovery platform was successful at seeding pipelines, and today, the two most advanced compounds, a P38 kinase inhibitor and a CXCR2 antagonist, are in Phase 2 clinical trials with BMS and Schering-Plough (now Merck). Dr. Webb volunteers as a member of the Board of Directors for the Society of Biomolecular Screening. She worked toward the successful merger of SB.S. with the Association for Lab Automation to found the Society for Lab Automation and Screening (SLAS). She is a consultant at Mount Sinai School of Medicine for the Technology Development Fund; a member of the Advisory Council for the College of Science and Mathematics at Montclair State University; and was an advisor to the Sino-American Pharmaceutical Association in 2000- 2002. She also serves as a guest editor and peer reviewer for journals, and has co-authored 90 papers.
Greg Wiederrecht is Vice President and Head of External Scientific Affairs (ESA) in the Merck Research Laboratories division of Merck & Co., Inc. where he has been employed for the past 24 years. ESA is responsible for the scientific assessment of all licensing, partnering, and acquisition opportunities for Merck. Dr. Wiederrecht's responsibilities include the management of a group of 66 scientists and administrators, distributed worldwide and divided by various therapeutic and platform areas, who identify and assess opportunities outside of Merck's walls. Dr. Wiederrecht holds a BS degree from the University of California, Irvine and a PhD in biochemistry from M.I.T. Before joining Merck in 1989, he was a Helen Hay Whitney Post-Doctoral Fellow and an American Cancer Society Senior Post-Doctoral Fellow at Caltech.
Anthony J. Yanni is Head of Patient Value and Strategy, Sanofi-Genzyme Global R&D Group. Following his years in clinical practice and hospital administration, Dr. Yanni entered the pharmaceutical industry and has worked in vaccine development at Sanofi Pasteur and served as Senior Director of Medical Value and Strategy with Sanofi prior to his current role. Much of his current work involves developing and applying processes that allow the patient voice to be more directly involved in the early developmental process; impacting both pre-clinical and early clinical development programs. He also currently co-leads an organizational initiative "Patient Engagement in the R&D Process" which will systematize and make more efficient the ability to engage patients throughout the developmental process. Dr. Yanni received his BS from the University of Scranton, an MD from Drexel University's School of Medicine, and an MBA from the University of Massachusetts at Amherst. Moderators and Panelists


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Account comes at trial of U.S. soldier accused of killing 16
JOINT BASE LEWIS- McCHORD, Wash. A U.S. agent who investigated the massacre of 16 civilians in southern Afghanistan earlier this year recounted the livid reaction from local villagers and said Wednesday it was weeks before American forces could visit the crime scenes less than a mile from a remote base.
By that time, bodies had been buried and some blood stains had been scraped from the walls, Special Agent Matthew Hoffman of the Army's Criminal Investigation Command said. Other stains remained, on walls and floors. Investigators also recovered shell casings consistent with the weapons Staff Sgt. Robert Bales reportedly carried and a piece of fabric similar to the blanket prosecutors say he wore as a cape during the killing spree.
Hoffman testified during the third day of a preliminary hearing for Bales, accused of slipping away from his post at Camp Belambay in the middle of the night to commit the killings.
The hearing, expected to feature testimony from some Afghan soldiers and villagers Friday and Saturday nights, will help determine whether his case advances to a court martial on counts of premeditated murder. Hoffman arrived at Belambay to investigate hours after the March 11 massacre, but he and his colleagues weren't able to reach the two villages where the killings occurred. An angry crowd of local residents gathered outside the post, he said, and any time they could see an American soldier, they became enraged.
Afghan investigators got out to the scenes that day, where they engaged in a firefight. They recovered some evidence and took photos that they turned over to U.S. authorities. But Hoffman and his colleagues didn't visit until April 2. He also said Bales tested positive for steroids three days after the killings.
Bales, a 39-year-old Ohio native and father of two from Lake Tapps, Wash., betrayed no reaction as an Army doctor, Maj. Travis Hawks, gave clinical descriptions of treating the wounded villagers at a nearby forward operating base. One young girl had a large bullet wound in the top of her head, he said. She was unresponsive at first, but survived after treatment.
A woman had wounds to her chest and genitals, but she and her relatives insisted the male doctors not treat her. Prosecutors displayed photos of the victims being treated.
Earlier Wednesday, a friend testified Bales seemed remorseful after being taken into custody. Defense witness 1st Sgt. Vernon Bigham testified by video from Kandahar Air Field in Afghanistan.
A prosecutor, Lt. Col. Jay Morse, has said Bales spent the evening before the massacre at his remote outpost of Camp Belambay with two other soldiers, watching a movie about revenge killings, sharing contraband whiskey from a plastic bottle and discussing an attack that cost one of their comrades his leg.
Within hours, a cape-wearing Bales slipped away from the post and embarked on a killing spree of his own, Morse said. He attacked one village then returned to Belambay, where he woke up a colleague and reported what he'd done, Morse said. The colleague testified that he didn't believe Bales and went back to sleep.
Bales headed out again, Morse said, and attacked the second village before returning once again in the pre-dawn darkness, bloody and incredulous his comrades ordered him to surrender his weapons.
Bales has not entered a plea, and isn't expected to testify.


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Life would be easier if people listened from time to time.
I told you
you would need me
and that one day
you would want me back
I said to bite your tongue
and to not attack
but you did not hear my words
and instead persisted
in completely destroying
the last of our relationship
Welcome to Authspot, the spot for creative writing.
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Go on WindOnFire it probably has more stuff in it, maybe? Then again probably not, NO, no it doesn't.
User Profile
- Joined:
- Tue 23rd Sep 2008
Recent Comments
Exactly WindOnFire Gyrostarr and Space Invaders I'm just not too interested in Gravitronix but Helix has shallow gameplay but probably has mor exercise than balance motivated Wii Fit
I would'nt be bothered with this it's a stick thing moving his body like a Disco Mum no thanx
I think 1500 for this game is wrong so I'll pessimestic too and go for 1500
Sorry Tides of Chaos yeah it is ESRB's job cuz they rate all games actually over here it's PEGI I think and that's Nintendo's job to make sure the game is playable and release it when they feel ready.
And thanx WiiWare World for not kicking me out thanx
I think it takes about a week cuz Nintendo have to play through to see if there is any violence and once they know it's alright they rate it then release it.
Sorry I was in a rush but world of Goo is ready for approval hopefully it'll come to Europe
D'oh nearly first comment
Well as long as the worst game ever Platchen and SPOGS don't come on the NA wiiware list will be saved you just have to get rid of Pong Toss now and then your list will be clean of bad games, YAY!
I'm with you Silent J "DEATH TO SPOGS, DEATH TO SPOGS" never to be seen again forever YAY!
I have some news: GOOD BYE and GOOD RIDDANCE SPOGS racing
I wonder who will be off next week? Hopefully Pong Toss
LOL truly Plattchen is obviously not getting any good responses anywhere
How come Pong Toss is still there? It has been ages and it's rubbish people come on it's dismal and I'm sure it's worse than SPOGS racing come on people force Pong Toss outta there cuz us Brits might start getting the wrong impression but well done to MM9
I love chess but I might get it just for WI-FI since I already have a chess board but I'd probably get a whopping good game from Japan cuz I like myself a good opponent but I do hope this comes to EU.
I like all the modes of Bomberman Blast. Air Raid makes you panic alot but is alot of fun seeing everyone on WI-FI running around like headless chickens it's hilarious I just wish it was in NA then us Brits could give you Americans a boot up the butt, no offence.
looks quite boring to me if it's released I think I'll wait for the review
Do you have any news on Lostwinds WWW cuz I'm getting really impatient (it's so annoying) please pester PR a little more please (crying).
WOW!! That's alot of stuff to unlock. WOW!!!


text:
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The Rev. Jerry and Sue Leffew will celebrate their 50th wedding anniversary on June 25.
Family and friends will help them celebrate with a party from 3 to 5 p.m. June 27 in Ten Mile Community Center.
Ninety-one-year-old Ruth Johnson, center right, and her family celebrated five generations with the birth of Johnson's great-great-granddaughter, Brianna Denton.
Brianna was 2 months old when she and her family traveled from Tunnel Hill, Ga., for a five-generation get-together.
The family includes, from left, daughter Rosie Johnson Denton, 62, holding Brianna; grandson David Denton, 42; Johnson; and great-granddaughter Elizabeth Denton, 20.
Josiah Miller celebrated his 12th birthday on June 9.
He celebrated with laser tag and a pizza party with his parents, best friends and brother.
He is the son of Ben Miller and Holly Culleton.
Grandparents are Len and Gina Jackson of Harriman, and Randy and Vicki Miller of Iowa.
Josiah has a brother and best buddy, Zackary.
Mr. and Mrs. Tommy Carter will celebrate their 60th wedding anniversary on June 4.
Mr. Carter and the former Jean Phillips were married on June 4, 1955, in the Frost Bottom community of Oliver Springs.
He is retired from Oak Ridge National Laboratory, and she is retired from ORNL Federal Credit Union.
The couple has two children, three grandchildren and two great-grandchildren.
Robin and Craig Freels, and Michael Plemens, all of Harriman announce the forthcoming marriage of their daughter, Grace Danielle Plemens, to Todd Shilling Taylor Jr.
He is the son of Todd and Denise Taylor of Harriman.
The ceremony will be in June at the Knoxville Zoo.
The bride-elect is the granddaughter of Dan and Debb Harper of Harriman, and Reed and the late Josephine Plemens of Harriman.
She is a Harriman High School graduate and a 2015 graduate of Tennessee Tech University with a degree in art education.
Babies born at Methodist Medical Center, Oak Ridge, to Roane County parents:
March 30 — Amanda St. Onge, Rockwood. A boy, Carter Michael Robert, 8 pounds, 0 ounces. Grandparents: Debra St. Onge.
April 12 — Jessica Marie Stone and Daniel Kencade Frost, Harriman. A boy, Jackson Noah Kencade, 5 pounds, 9 ounces. Siblings: Daniel, Joanna and Ashton. Grandparents: Jeff and Jackie Shipwash; Renee Shipwash; Freddie Davidson; Daniel Davidson; Richard and Lisa Ervin.
Louise Warmley of Harriman celebrated her 95th birthday on May 12.
She was born in Harriman on May 12, 1920, to the Rev. Preston and Troy Anderson, both deceased.
The oldest of seven children, she attended school in Alcoa, graduating from Hall High School. She later married William Warmley Jr., now deceased.
They had two children, Marvin Anderson and Dorothy Graham, six grandchildren and 22 great-grandchildren.
Babies born at Methodist Medical Center, Oak Ridge, to Roane County parents:
Jan. 3 — Amber Leasure and Mitchell Butler, Oliver Springs. A boy, Chayce Wayne, 6 pounds, 8 ounces. Grandparents: James and Beth Haney; Mike and Joy Jackson.
• Bethany Dykes and David Redwine, Rockwood. A girl, Aubrianna Elaine, 5 pounds, 14 ounces. Sibling: Caden. Grandparents: Jeff Redwine and Tracy Redwine.
Mr. and Mrs. Steven Plemens of Harriman and Mr. and Mrs. Edward Tedder of Friendsville announce the forthcoming marriage of their daughter, Carrie Elizabeth Tedder, to Michael Richard Koehler.
He is the son of Virgil and Diane Koehler of Louisville.
A June ceremony is planned.
The bride-elect holds a master's degree in music performance from the University of Tennessee. She is band director at The Episcopal School of Knoxville.
Kent and Stephanie Cleaver of Franklin announce the forthcoming marriage of their daughter, Cayla Cleaver, to Nathan Basler.
He is the son of Garland and Jama Basler of Kingston.
The ceremony will be on May 23 in Franklin. A reception will follow.
Formal invitations have been sent.
The bride-elect is the granddaughter of Frank and Charlotte Cleaver of Nashville, and Helen Hughey of Frankin.
She is a graduate of O'More College of Design with a degree in interior design. She is employed with Allard Ward Architects, Nashville.
Copyright © 2015
The Roane County News is your source for local news, sports, events, and information in Roane County and Kingston, Tennessee, and the surrounding area.


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Brandtech Dispensette Organic Bottletop Dispensers are the solution for handling organic solvents, concentrated acids and peroxides. The "floating piston" design eliminates the seals that often wear and fail on other dispensers. They have a reinforced discharge tube with threaded safety cap, SafetyPrime valve to conserve solvents and reduce "spurting" while priming, safety discharge system to reduce the chance of inadvertent dispensing, and a telescoping filling tube and thread adapters that fits most lab bottles.
Adjustable Volume Analog Dispensette Organic Models feature a sliding pointer for volume adjustments. Calibration adjustments are made using the provided calibration tool.
Digital Easy Calibration Organic Models enable accurate and reproducible volume setting with an easy-to-read display and a convenient adjustment knob. Simply turn the knob to the desired volume setting. The mechanical digital display indicates the set volume.
All units have a standard 45 mm thread plus additional adapters for other bottle sizes (units ≤10 mL have 24, 28, 33, and 38 mm adapters; units >10 mL have 33 and 38 mm adapters). Units include discharge tube, telescopic filling tube, mounting tool, certificate of performance (with serial number), and operating manual.
How can we make Daigger.com better for you?
Due to shipping restrictions, items marked as "Hazmat" cannot be sold online. Please call Daigger's Customer Service at 1-800-621-7193 or send an email to firstname.lastname@example.com for assistance placing an order for these items. Note that this restriction only applies to items marked as hazardous materials.
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text:
Somethings should never be asked of friends lol
Submitted by bill
Share More
Lauraine Keewasin:
March 27, 2013 at 10:10 pm
Didi Paris:
October 6, 2012 at 12:03 pm
Is she going there for that? (finger...) lol
Edduardo Rendon Damian:
October 3, 2012 at 11:53 pm
HAHAHAHAHAHA I bet she's single.
April Marie Quinn:
October 3, 2012 at 8:19 am
Midnight... always midnight.... lol
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Why sheepskins for Yoga?
Animal skins have been used for millennia around the world for yoga and meditation.
They provide warmth and insulation from the earth's magnetic field thus making meditation easier.
They greatly enhance Yoga practice giving you a warm, cosy experience, which feels beautifully supportive especially at relaxation time.
The sheepskins are a by-product.The sheep do not die for their skins, therefore we are truly up-cycling and Yogi Bhajan said that this blesses and helps to liberate the animal soul.
Sheepskins make stunning accessories for the home, on the sofa, the bed or the floor. They add comfort for driving in the car, can be ideal as Equestrian accessories and are great for the elderly and babies.
Sat nam
I am Kundalini Yoga Teacher affiliated to KYTA and a community care worker for local elderly people. I have created this small family business in South Devon to supply you with these amazing Sheepskins, handmade lavender eye pillows and bespoke waterproof duffle bags for carrying it all in to your classes, workshops, retreats and festivals.
Every final product has been either handmade or home grown here in Devon.
Looking after Mother Earth and proud to be Made In England, we encourage and support local communities and small businesses, therefore everything has a tiny carbon footprint.


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Mikuni Japanese Restaurant Map
4323 Hazel Ave.
916-961-2112 | Make Restaurant Reservations | Menu
Now that you know where you want to enjoy a meal, it's time to find the restaurant. Print out this Mikuni Japanese Restaurant map and take the driving directions with you so you can locate the restaurant easily.
Check out the 2015 edition of GAYOT's Annual Restaurant Issue, which features the Top 40 Restaurants in the US and more.


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WASHINGTON (AP) - The St. Louis Cardinals have put All-Star shortstop Rafael Furcal on the 15-day disabled list because of a strained right elbow.
Furcal left Thursday night's game at Washington after making a pair of throws in the sixth inning. He later said he felt a pop in his elbow.
The defending World Series champions made the move before Friday night's game against the Nationals. St. Louis is leading in the race for the second NL wild-card spot.
Shortstop Pete Kozma was promoted from Triple-A Memphis. He had two stints with St. Louis last year, and was in the starting lineup Friday night at Washington.
The Cardinals also said outfielder Lance Berkman would be activated from the 15-day DL on Saturday. He's been out since Aug. 3 with an injured right knee.
(Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.)