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84 Coney Island Dr.
Sparks, NV 89431
eCycleBest is a electronics recycling service, buying old devices, giving them new life and then selling them.
For more information: visit e-Cycle Best or call 1-888-634-4409 (7 a.m. to 4 p.m. PST Monday - Friday)
Accepts: Blackberry, cell phone, iPad, iPhone, laptop, Netbook, Notebook, smartphone, and Tablet PC.
This information was compiled from information provided by each agency or business and is updated periodically. Although local government staff has attempted to include as many Clark County recycling listings as possible, these resources should not be viewed as a comprehensive list. Due to space limitations, most businesses located outside of Clark County have not been included.


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jGuru Forums
Posted By:
Posted On:
Wednesday, April 18, 2001 04:46 AM
I am using weblogic 5.1 and JDriver for MSSQLServer 7 when iam runing simple Java program it giveing no errors where as when i am runing simple JSP file its giving an error ClassNotFoundError weblogic.jdbc.mssqlserver4.Driver
what r the settings i have to do.
i set the path for mssqlserver license and classes what else i have to do.
please help me.

subset: commoncrawl


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Texas Rangers sell Soto to Oakland
ARLINGTON — If right-hander Yu Darvish returns this season, and there is increasing doubt about that, he will be without his favorite catcher.
The Rangers on Sunday sent Geovany Soto to Oakland for "cash considerations," believed to be about $300,000. Soto will earn $620,455 for the remainder of this season.
General manager Jon Daniels said the club made the move to get a better understanding of Chirinos and Tomas Telis, who will receive his first major league exposure. Telis will join the club Monday in Seattle.
"We want to take a look at both of those guys," Daniels said. "Plus, it gives Geo an opportunity to win. Hopefully, the situation benefits everybody."
In parts of three seasons with the Rangers, Soto's biggest contribution was his working relationship with Darvish. In 26 starts with Soto, Darvish is 13-6 with a 2.83 ERA. Darvish is 26-19 with a 3.46 ERA with all other catchers.
Telis, 23, is in his sixth professional season. He reached Triple-A for the first time this season and hit .345 with an .866 OPS in 147 plate appearances at Round Rock. In 19 games at catcher with Round Rock, Telis had one error and threw out three of 17 attempted base-stealers.
Briefly: Darvish did not throw for the 11th consecutive day since going on the disabled list. He could undergo another MRI test soon to determine the state of his elbow. … Outfielder Jake Smolinski hopes to have the walking boot removed from his left foot soon, allowing him to resume baseball activities. The Rangers are uncertain if Smolinski will be able to play again this season. To make up for lost time, Smolinski will play for Obregon in the Mexico winter league. … Catcher Chris Gimenez, traded from Triple-A Round Rock on Saturday, joined Cleveland and expressed joy at the move. "It's really nice to be [above] .500 and not 30 games below," he told reporters in Cleveland. … With eight days remaining in the regular season, Joey Gallo continues to lead the high Class A Carolina League in homers with 21 in 189 at-bats. The Rangers promoted Gallo to Double-A Frisco on June 6. Courtney Hawkins of the Chicago White Sox is second to Gallo with 19 homers in 426 at-bats.


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'Those aren't real nails' says fat, odious foul-mouthed, fear-mongering, low-life, drug-addicted scumbag.
Right-wing American shock-jock Rush Limbaugh took time out from his busy schedule of sacrificing chickens and small children to the Dark Lord of Hades, whoring for the Republican party and desperately trying to hide the fact that he is, in fact, everything he professes to hate this morning, to cast doubt on the authenticity of Jesus' crucifixion.
'I don't buy it for a second', spluttered Limbaugh, whilst masturbating furiously over a computer generated picture of George W. Bush in fish-nets and high-heels. 'He's wriggling around on that cross like a spastic worm, arms flapping all over the place. He's faking it. Faking it! He's a professional liar! Those wounds on his hands? Ketchup! Nails through the feet? Bought them in a joke shop! Crown of thorns? Crown of cotton wool more like. Spear through the side? Barely tickled him, the con-artist. And I ain't the only one that says so either. The Koran says the same thing...'
+Dateline Hollywood+
Christopher Reeve faked his illness says Limbaugh
+Bill Hicks on Limbaugh+


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January 6, 2011
Scott Kushner
Stability.It's a trait that everyone claims to want, but most fans and schools don't seem to strive for it.In an era where coaches seem to either find themselves on the hot seat or positioning for a new job, the length of tenure is getting shorter and shorter around FBS football.But rarely has it struck so fast as at University of Pittsburgh when newly hired coach Mike Haywood was fired for a domestic dispute just two weeks after taking the job.It's a development that hit Evan Tatford hard.The three-star tight end prospect was receiving lots of interest from Haywood's staff when the coach was at Miami (OH) during the 2010 season and when he made a move to Pittsburgh, Tatford was asked to come visit the Big East school.However, when news came down New Year's Day that Haywood had been released from Pitt, Tatford's recruitment took a turn."There are these whole new coaching staffs that seem to be showing up everywhere," Tatford said. "I want to go to a place where I can go to school for four or five years and be confident that I will be playing for the same coaches throughout my time there. It's important to have that stability around."Now the 6-foot-6, 230-pounder is adjusting his schedule. On the final two weekends of the recruiting season, Tatford will visit Memphis and hometown UL-Lafayette, each of whom has a coach entering its first or second year with the program.Despite plenty of communication with Tulane over the year, the instability surrounding the future of fifth-year coach Bob Toledo and his staff, as well as a tightly packed depth chart at tight end (which will be adding at least two more - Josh Drum and Greg Thomson - in the 2011 class) have left Tatford unsure about where he stands with the Green Wave.However, as he pieces together his last open weekend of recruiting (on Jan. 14), Tulane still remains a viable option. Along with friend, St. Thomas More teammate and Green Wave commitment Sam Scofield, Tatford was in the Superdome for TU's games against Army and Rice where he built a solid relationship with recruiting coordinator/tight ends coach Doug Lichtenberger in the process."(Tulane) is still an option for sure and I like a lot of people there," Tatford said. "But I didn't know what was going on for that (Jan. 14) weekend with Pittsburgh and everything since there's still some assistants I still know at Pitt."Tulane is a place I like and it's still definitely worth a look at, but I only have that one weekend open and I am looking to fill it. "Now, with less than a month before signing day and most of his itinerary already set there's no need for Tatford to make out a list of frontrunners.Instead he is sticking by a list of priorities and will judge each school based on their individual criteria."The first and foremost thing is the education and some place that can take to a place past football and that's first," Tatford said. "Then the stability of having a coaching staff that I feel is going to be there for my college career is important as well. Of course I the depth chart matters to because I want to go to a place where I have a chance to play and will get the right opportunity to prove myself."Whichever place kind of fits all of those things the best is probably going to be where I end up. I'm interested to see how it works out." ...More... To continue reading this article you must be a member. Sign Up Now!
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- Filed Under
One hundred years ago this month, Delaware became the 36th state to ratify the 16th Amendment to the United States Constitution, and the federal income tax was made legal.
We all know people who would probably say that Feb. 3, 1913, was a dark day for America. And the overwhelming majority of the Republican members of Congress have signed a pledge that they will not vote for a tax increase.
Fortunately for the country, Republicans and Democrats in Congress voted for tax increases as part of the "fiscal cliff" agreement. I believe that most of us realize, as Oliver Wendell Holmes said, that "taxes are the price we pay for civilization."
The single most important spending priority to ensure robust economic growth and an improved civilization is education.
We have a serious long-term deficit problem and reducing expenditures must be part of the solution to the problem. But most economists agree that by far, the most effective way to deal with the deficit is to increase the rate of growth in our economy.
Virtually all of them also agree that the key to long-term economic growth in a global economy is a competitive workforce. That means we must do whatever it takes to make sure our young people have the training and skills to attract and expand the industries of the 21st century.
One of the most destructive things we have done since the onset of the Great Recession has been to cut funding on education. This has forced local school boards to fire tens of thousands of teachers and drastically slash school budgets.
California is an example of the long-term effects of refusing to adequately fund education. In the past 30 years, a series of referendum votes limited the ability of the state and its local governments to maintain what was once one of the best educational systems in the nation. Californians spent 5.6 percent of personal income on education in the 1960s; they now spend 3.6 percent. The state now ranks 42nd in percentage of students who graduate from high school.
Gov. Jerry Brown has made increased spending for K-12 education the top priority in his new balanced budget. Too many other states are not doing that, and the country as a whole will suffer as a result.
Mindless cutting of funds in the name of deficit reduction is a sure way to ensure larger long-term deficits. When more Americans have the skills needed to succeed in our changing economy, the unemployment rate will down and the economy will grow, tax revenues will increase and a balanced budget becomes feasible.
The thoughtful increase in taxes under Presidents George H.W Bush and Bill Clinton led to large budget surpluses in the late 1990s. Federal revenue was almost 21 percent of GDP then; today it is less than 16 percent.
We had historic growth when paying much higher taxes than we pay now.
Our taxes pay for a lot of good things in addition to education, from our national defense to Medicare and Social Security. Keep them in mind when you hear the "no taxes for anything" arguments.
And maybe thank those Delawareans who had the foresight to welcome a federal income tax.
Ted Kaufman is a syndicated columnist.


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This is the March 20, 2013 news archive. View today's Phillies rumors and news.
Worthy Champs: The Dominican Republic beat Puerto Rico 3-0 to ta…CNNSI.com Updated Mar 20, 2013The Dominican Republic beat Puerto Rico 3-0 to take the WBC title. It was their actions after the final out though, writes Tom Verducci, that could prove even more significant.Share Tweet
Phillies catcher Carlos Ruiz has accepted ban with humilityphilly.com Mar 20, 2013CLEARWATER, Fla. - Along the back wall of the clubhouse, in front of the locker he has long called home, Carlos Ruiz sat and fiddled with an iPhone. The lineup card for the afternoon game against the Yankees was hanging on the bulletin board across the …Share Tweet
Sports Columnists
Don Banks: Outrage over new helmet rule much ado about nothingMar 20PHOENIX -- Emmitt Smith, Matt Forte, Eric Dickerson and running backs everywhere may squawk, but every change the NFL makes these days on behalf of player safety makes somebody squawk, doesn't it? Should the league really care? Not if it feels like it's…
NFL owners meetings - Pro Bowl survives but change is likelyMar 20The Pro Bowl will survive for next season, but changes are likely. Plus: playoff expansion talk, rules changes and more from the owners meetings.
NBA - Most intriguing 2013 draft prospects in the NCAA tournamentMar 20Our five-man team names the most intriguing NBA draft prospects in each region of the NCAA tournament.
NFL owners end tuck rule, approve helmet penaltyMar 20In votes Wednesday, the NFL's owners eliminated the tuck rule and agreed to a rule change that would ban offensive players from using the crown of their helmets against defenders in the open field.


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Records at the Kansas Board of Cosmetology go way, way back — all the way back to the time Ellen Chester, who had just turned 19, applied for her license to style hair in Kansas.
Records at the Kansas Board of Cosmetology go way, way back — all the way back to the time Ellen Chester, who had just turned 19, applied for her license to style hair in Kansas.
Ellen Chester Rowden Bradley recently celebrated her 90th birthday and is still styling. She no longer has her own shop, but works Mondays at Total Image Salon.
Mary Lou Davis, executive director of the Kansas Board of Cosmetology, recently presented Bradley with a certificate in recognition of her 73 years of service to the profession.
Davis had been contacted by Saundra Bradley Kneebone, who worked in Bradley's salon for many years.
"I thought they should do something for Ellen, at least send her a card," said Kneebone, who is also Bradley's stepdaughter. "They asked me if Ellen was still ambulatory and could come to a ceremony if they held one for her. I told them that she drives herself to work every Monday."
The ceremony was held in the center court at Meadowbrook Mall, following company-wide "Fear Factor Perm Challenge" training session at the J.C. Penney Salon.
"We were blessed to be able to have Ellen with us," said Dawnelle Burris, salon supervisor.
"I couldn't understand why Saundra wanted me to come to J.C. Penney with her," said Bradley, who was completely surprised by the honor.
"We got in Ellen's files, and found her original application from April, 1937," Davis said, displaying the yellowed paper form with attached photo. "In those days you had to submit a photo of yourself with your application. On April 22, 1937, Ellen took her state examination, and it should come as no surprise that she made very good scores."
Bradley had started at Ray's Beauty Salon in Lamar, Mo., before opening her first salon, the Thrift, in Liberal, Mo. She worked at the Vanity Box and Jones Store Salon in Pittsburg before opening Rowden's Sleek and Chic in 1965.
In addition to the certificate from the board, Bradley also received a letter from Kansas Gov. Kathleen Sebelius, praising her for her entrepreneurial spirit and her devotion to her clients. A decorated cake was served in her honor.
"I sure didn't expect all this just for getting old and doing what I wanted to do," Bradley said.
Davis said that her staff had enjoyed researching Bradley's files. "Normally my staff processes applications for licenses and renewals, but it's not personal — they don't get to know the people," she said. "Doing this was fun for them."
Bradley is definitely one of the oldest, if not the oldest, active stylists in Kansas. "We do have several in their 80s who still provide services," Davis said. "These women are an inspiration to young stylists."
Page 2 of 2 - She noted that Bradley had recently renewed her state license. "It's good until 2010," Davis said. "Ellen, we'll be looking for your next application for renewal in 2010."
That just might happen.
"I plan to live to be 120 and keep doing hair," Bradley said. "I'll probably drop dead in the middle of a job, they'll kick me to the side, and the customer will ask who's going to finish her up."
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Location, ST | website.com


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Daily NewsView All News
Spain – Unemployment hits new high and things are to get worse
Unemployment in Spain has reached a new high rising to levels last seen in 1976. The jobless rate increased to 24.6% between April and June, up from 24.4% in the previous quarter, the latest official statistics show.
With 5.7 million Spaniards or nearly one in four now looking for work, the federation of temporary employment agencies (AGETT) said that things are likely to get even worse. The association said the increase in unemployment was "really bad" and said the third quarter of the year will "in no way be good" in terms of employment.
It further argued that the figures are an "unmitigated evil" and urged to rethink labour market policies which are destroying industrial jobs. AGETT warned that the increase in unemployment, which was higher than expected, also "prelude" a further deepening of the recession.
And analysts agree. Speaking about the latest jobless rate, economist at Capital Economics Ben May said that "it's another example of the dire position the economy is in, and with the economy unlikely to expand anytime soon, and probably more likely to fall deeper into recession, things are only going to get worse."
The Spanish economy has deteriorated since 2008 and the latest slump is expected to last well into 2013, with the government estimating unemployment to float at 22% at its best until at least 2015. Young people have especially been hit by the high jobless rate as EU statistics show that half of those aged under 26 are looking for work.


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Top VFX Professionals from Weta Digital, CNN, and Electronic Arts Advance the CheckMate Industry Standard
June 12, 2012, New Orleans, Louisiana – TurboSquid, the world's source for quality 3D models, announces the formation of the CheckMate Advisory Board to guide the future of the CheckMate 3D modeling standard. TurboSquid created the standard in 2011, and since that time, a variety of 3D model customers have sought to participate in the standard's ongoing development. In response, TurboSquid convened a powerhouse of artists to form the CheckMate Advisory Board to take on this responsibility.
Board members include industry leaders from distinguished studios such as Weta Digital, Electronic Arts, CNN, Blur Studio, and The Mill. The first meeting allowed for a high-level discussion of topics, ranging from topology and texturing needs to in-house archive and resource management. "We're proud to be invited onto the Advisory Board to help review the Checkmate standard," says James Ogle, Lead Modeler at Weta Digital. "We're happy to share our experience and contribute to criteria that will make the Checkmate standard valuable to a production of any size." (more…)


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John Frank Corral
Position: K
Height: 6-2 Weight: 224 lbs.
Born: June 16, 1955 in Chihuahua, Mexico
High School: Norte Vista
College: UCLA (school history)
Drafted by the Los Angeles Rams in the 3rd round (78th overall) of the 1978 NFL Draft.
Weighted Career AV (100-95-...): 13 (6196th overall since 1950)
1-time Pro Bowler (fine print)
Promote your website or business by sponsoring this page for $5 on Pro-Football-Reference.com. Your message will replace this ad.


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- Filed Under
Oaklawn Elementary School is a finalist in the Clorox Co.'s Power A Bright Future grant program. We need your help to win! Please help bring a new improved playground to our kids. Through Dec. 19, you can vote at www.PowerABrightFuture.com and via text once a day for our program.
The program that receives the most votes overall will be awarded the $50,000 grand prize grant, and the next top vote-getters in the Play, Create and Explore categories will each be awarded $25,000 grants. Three lucky schools will be selected, one from each category, to receive a $25,000 judge's choice grant.
To vote, text 2125pbf to 95248.
Vote online at https://powerabrightfuture.clorox.com/nominees/details/?nid=2125. Vote one time every day! Spread the word!


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Travelodge Stratford Upon Avon
Price FromView Rooms
- Very Good
- 92 guest reviews
"Great accommodation. Staff very good & polite. Shame about other inconsiderate noise residents. Other than then Great place to stay...."
"Clean good food ,very helpful staff ,would recommend,and stay again..."
"Helpful staff clean good food,enjoyed my stay..."
"Budget accommodation 10 minutes walk from the town centre. Clean but basic. Good value if that's all you want...."
About the hotel
Explore the home town of Shakespeare when you stay at the Travelodge Stratford Upon Avon Hotel. With ample on site parking and just 0. 7miles from Stratford train station, this hotel gets you right where you want to be, being just 1.
2 miles from the Royal Shakespeare Company. You're also within 1. 5 miles of Shakespearience and The Shakespeare Birthplace Trust, offering a fantastic opportunity for theatre lovers. For more modern pursuits, you can shop in the Maybird Retail Park or visit the town centre, both located nearby. With so much going on, both old and new, this is one of the best hotels in Stratford Upon Avon for visitors to the area. The hotel has recently been updated with our fresh new look and features Travelodge's new room design complete with the Travelodge Dreamer Bed by Sleepeezee, featuring a 958 pocket sprung mattress, cosy 10. 5 tog duvet, and four plump pillows, so you can be sure of a great night's sleep. Early/Late Check-In/Out Service – if you're looking to make the most of your day we can offer an Early Check-In service from 12:00noon and a Late Check-Out Service until 2pm so you have more time to relax - cost is £10 per service, per room, subject to availability - bookable direct by telephoning the hotel. For guests wishing to bring domestic pets please contact LateRooms. com for more detail on charges and terms and conditions. Please note that Guide dogs, Hearing dogs, and other animals to aid disability are exempt from charge.
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Room Availability
Showing Wednesday 2 December 2015 to Thursday 3 December 2015Change Search
Facilities Show/hide
- Main
- Hotel Non-Smoking Throughout , Disabled Facilities
- Hotel services
- 24 Hour Reception
- Family friendly
- Cots available , Pets Allowed
- Parking
- Car parking available onsite
- Business
- Wi-Fi Available , Wi-Fi Available In Public Areas , Wi-Fi Available In Rooms
- Dining
- Restaurant , Bar
- In room entertainment
- TV , [Channels] News , [Channels] Music , [Channels] Childrens
- In room facilities
- Tea/Coffee making facilities in each room
- Accessibility
- Disabled Access Public Areas , Disabled Access Bedrooms , Wheelchair Access , Wheelchair Access To Reception , Wheelchair Access To Restaurant , Wheelchair Access To Bar
Can't find the facilities you're looking for?
- Call us on 0333 300 1007 and we'll help find the perfect hotel for you
- Call
Useful Info Show/hide
- From 15:00 hours
- Until 12:00 hours
- 13/07/2014 to 31/12/2016 - Payment must be made on arrival at the hotel, by either credit/debit card/cash. When paying cash, either photo identification (passport/driver's license), or a valid credit or debit card are required. The price shown is based on the occupancy and dates you have searched for. Prices and availability are subject to change based on the arrival date, number of nights and occupancy searched for. All prices are inclusive of all local taxes.
- Pets are allowed
Customer Reviews
Our reviews are from genuine LateRooms.com customers. We verify that the customer has stayed before leaving a review.
Very Good
79% would recommend it to a friend
Customer service
Food quality
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Easy to find. Good reception, good clean room
Great accommodation.
Staff very good & polite. Shame about other inconsiderate noise residents. Other than then Great place to stay.
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- Filed Under
GALION -- The second annual Avita Health Foundation Divas and Darlings event will be 5:30 to 9 p.m. Oct. 25 from at St. Joseph's Activity Center, 115 N. Liberty St.
Proceeds from the event will benefit women's health services at Avita Health System.
Early registration is encouraged. Tickets, $45, can be reserved by calling Tammy Schott, Avita Health Foundation director, at 419-468-0566.
This year's event will feature a Mardi Gras theme, "Life is a Masquerade," and will include Mardi Gras-style buffet stations, unique raffles and a Mardi Gras mask contest. Pat Wynn Brown, a cancer survivor and humorist, will provide entertainment through her "Beauty School" comedy performance.
A special ladies-themed silent auction will include ski packages, seasonal décor, a handbag raffle and a "Chocolate & Sparkles Raffle" for a chance to win a jewelry ensemble worth more than $600. A live auction will conclude the evening with vacation home destinations to Hilton Head, S.C., and Caswell Beach/South Port, N.C., chauffeured limousine services, a catered gourmet dinner and more.
This benefit is designed to raise awareness and funds for women's health services for both Galion and Bucyrus community hospitals.


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This discount is available to all students who are 65 years of age or older.
The discount is tuition minus all federal and state scholarships/grants. This discount is available for all semesters the student is enrolled. This discount is non-transferable and not redeemable for cash. This scholarship in combination with any scholarships and grants cannot exceed the cost of tuition.
The application to apply for the Senior Citizen Discount is the Emmanuel College Application for Financial Aid which is available here. To be eligible for this discount the Free Application for Federal Student Aid (FAFSA) must also be filled out. The HOPE Scholarship and Georgia Tuition Equalization Grant Applications must be completed if a resident of the State of Georgia.
Students are eligible to receive this discount each year, provided that they maintained Satisfactory Academic Progress.


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Barack Obama
The 3rd Party Content of Whitehouse.gov
When Whitehouse.gov relaunched itself during Barack Obama's inauguration it included a clause in its copyright policy mandating that all 3rd party content on the site be released under our Attribution license. Until yesterday, there wasn't much third party content on the site. However, as of this writing, 13,785 people have submitted 16,561 questions and cast 508,450 votes in the site's "Open For Questions" section. President Obama will answer some of these questions on Thursday morning in a special online town hall.
While the copyright status of each individual question may not seem significant, all of the questions taken in aggregate are of unquestionable value for current and future generations of journalists, historians and citizens. By placing this corpus under our most permissive license, the Obama Administration has secured that the public will always have access to this unprecedented part of American presidential history.Comments Off on The 3rd Party Content of Whitehouse.gov
Recovery.gov Following Whitehouse.gov's Lead
Recovery.gov is the site that provides US citizens with the the ability to monitor the progress of the country's recovery via the The American Recovery and Reinvestment Act. As with Whitehouse.gov, the Obama administration is presciently using our Attribution license 3.0 for all third party content on the site, while all of the original content site created by the federal government remains unrestricted by copyright and therefore in the public domain.Comments Off on Recovery.gov Following Whitehouse.gov's Lead
Live from the NYPL & Wired Present: Lawrence Lessig, Shepard Fairey, and Steven Johnson
New Yorkers – next Thursday, February 26, Wired and Live from the NYPL will bring together Lawrence Lessig, Shepard Fairey, and Steven Johnson for a discussion about Lessig's new book, Remix: Making Art and Commerce Thrive in the Hybrid Economy. The conversation will take place at 7:00pm at the Celeste Bartos Forum at the New York Public Library (5th Avenue and 42nd Street). Tickets are $25 for general admission and $15 for library donors, seniors, and students. This is Lessig's final planned public discussion of remix and copyright issues, before he he heads to Harvard to direct the Edmond J. Safra Foundation Center for Ethics. Lessig, Fairey, and Johnson will be on hand after the talk to sign their respective books and posters.
Comments Off on Live from the NYPL & Wired Present: Lawrence Lessig, Shepard Fairey, and Steven Johnson
LIVE from the NYPL and WIRED Magazine kick off the Spring 2009 season with a spirited discussion of the emerging remix culture. Our guides through this new world—who will take us from Jefferson's Bible to André the Giant to Wikipedia—will be Lawrence Lessig, author of Remix, founder of Creative Commons, and one of the leading legal scholars on intellectual property issues in the Internet age; acclaimed street artist Shepard Fairey, whose iconic Obama "HOPE" poster was recently acquired by the National Portrait Gallery; and cultural historian Steven Johnson, whose new book, The Invention of Air, argues that remix culture has deep roots in the Enlightenment and among the American founding fathers.
Whitehouse.gov's 3rd Party Content Under CC-BY
As you may of heard, the new Whitehouse.gov launched today at 12:01pm during Barack Obama's inauguration. What you might not have noticed is that the copyright policy of the site stipulates that all 3rd party content is licensed under our most permissive Attribution license:
Pursuant to federal law, government-produced materials appearing on this site are not copyright protected. The United States Government may receive and hold copyrights transferred to it by assignment, bequest, or otherwise.
Except where otherwise noted, third-party content on this site is licensed under a Creative Commons Attribution 3.0 License. Visitors to this website agree to grant a non-exclusive, irrevocable, royalty-free license to the rest of the world for their submissions to Whitehouse.gov under the Creative Commons Attribution 3.0 License.
(emphasis added)
Congratulations to the 44th President of the US for choosing CC!Comments Off on Whitehouse.gov's 3rd Party Content Under CC-BY
¡ YES WE PUEDE !: CC-Licensed Compilation for Inauguration
L.A.-based record label and former Featured Commoner Vosotros just went live with their latest release ¡ YES WE PUEDE !, a compilation of artists covering American public domain classics in honor of next week's Presidential inauguration. The album features some amazing L.A. artists and is released under a CC BY-NC license, allowing others to share and remix the tracks for noncommercial purposes as long as Vosotros and the artists are properly attributed.
Choosing CC for the project is in spirit with the incoming administration's license use. ¡ YES WE PUEDE ! joins DJ Z-Trip's Victory Lap in the "awesome CC-licensed music inspired by the Barack Obama" category.
Comments Off on ¡ YES WE PUEDE !: CC-Licensed Compilation for Inauguration
Interviews with Creative Commons: Jamie, Eric & Fred
A couple interviews with CC board and staff have surfaced in the last week or two. BBC Radio 4 interviewed Creative Commons Board Chair James Boyle about the public domain and how Creative Commons helps enrich the environment of the mind. Before Jamie's interview, the Beeb chats with Chris Anderson talks about his new book FREE and the business models he's been researching.
In December, our Creative Director, Eric Steuer talked with Dog and Pony of The BNET Business Network. The Knight Foundation's Knight Pulse also interviewed Eric about how grantees can use our licenses in their projects.
I also answered some questions from Journalism.co.uk regarding how journalists can use CC licenses in their work. Finally, I chatted with Federal News Radio on Friday about Obama's choice to use CC on Change.gov, the recording of which you can download there.Comments Off on Interviews with Creative Commons: Jamie, Eric & Fred
DJ Z-Trip's Victory Lap: The Second Obama Mix
After hearing his massively successful Obama Mix, MoveOn.org contacted DJ Z-trip to create a new "Victory Lap" mix celebrating Barack Obama's election for the inauguration. Just as he did with his original mix, Z-trip has licensed his new mix one under our Attribution license, allowing anyone to reuse, remix and share it, even commercially.
Download the mix at Z-Trip's site.Comments Off on DJ Z-Trip's Victory Lap: The Second Obama Mix
Bulgarian President Chooses CC BY ND
The official website of the Bulgarian President Georgi Parvanov is now available under a Creative Commons Attribution-NoDerivs 2.5 Bulgarian license. Bulgaria's Ministry of Foreign Affairs has been releasing its material under the same license since 2006, but ordinarily, these websites would be under full copyright, explains CC Bulgaria Project Lead Veni Markovski.
"Bulgaria has taken a step in the right direction to complete its image as a country where the politicians are aware of the most advanced technologies and use them for the good of the society," Veni adds.
Government leaders in other countries are also choosing similar paths. The Armenian President Serzh Sargsyan licenses his official website under a Creative Commons Attribution-NoDerivs 3.0 Unported license, and governments in Australia and Mexico (pdf) use and recommend CC. Another licensing decision already bearing fruit is Change.gov, the website of US president-elect Barack Obama's transition team, which is published under the most permissive of Creative Commons copyright licenses – CC Attribution 3.0 Unported.
For a listing of more governmental uses of CC, please visit our wiki page: http://wiki.creativecommons.org/Government_use_of_CC_licenses.Comments Off on Bulgarian President Chooses CC BY ND
Change.gov's Choice Already Bearing Fruit
Less than 72 hours after the Obama-Biden Transition Team adopted our most permissive license for Change.gov, Cerado Ventana has built a Change.gov iPhone, mobile application, and widget. We will never know if this application would have been built if Change.gov hadn't chosen such a permissive license, but it just goes to show what interesting things can happen when you let the world know your work is free to be built upon.
We originally caught this via Twitter and Christopher Carfi's "Social Customer Manifesto" blog where he expressed thanks to Obama's team for using CC:
Thank you again to the Obama administration for opening up Change.gov with Creative Commons to make this possible, and thanks to everyone here on the team. You have been building killer technology, and have enabled us to create this new conduit for citizens and government to connect.
This is just the beginning of innovative uses of the content from Change.gov, so keep an eye out for more interesting applications and let us know about them.
Check out the widget after the jump.
Read More…
Lessig and others offer "Open Government" principles
A short follow-up to our post from yesterday about how Change.gov is now available under a Creative Commons license: Lawrence Lessig announces a set of "open government" principles intended to guide the Obama-Biden transition team's use of the Internet. Visit open-government.us for the letter and video that outline these principles, and read Ben Smith's post on Politico for more information about this project.Comments Off on Lessig and others offer "Open Government" principles
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All hotels in Tyler, Texas, United States of America
1 room, 2 adults
3303 Troup Hwy, Tyler, TX, 75701, United States of America, 0800-886-061 (New Zealand Toll Free)
Hawthorn Suites by Wyndham Tyler, Tyler
Lowest priceNZ$147
available on 07/12/2015
Price Match Guarantee
3-star Tyler hotel with outdoor pool
- Free hot/cold buffet breakfast, free Internet, and free parking
Main amenities
- Outdoor pool
- 24-hour front desk
- Coffee/tea in the lobby
- Air conditioning
- Daily housekeeping
- Free grocery shopping service
- Lobby fireplace
- Front desk safe
- Convenience store
- Laundry service
- Meeting room
- Picnic area
What's around
- University of Texas at Tyler (1.7 mi / 2.8 km)
- Tyler Museum of Art (1.9 mi / 3 km)
- Broadway Square Mall (2.3 mi / 3.7 km)
- Discovery Place Museum (3.9 mi / 6.3 km)
- Tyler Municipal Rose Garden Center and Museum (6.3 mi / 10.1 km)
When visiting Tyler, Hawthorn Suites by Wyndham Tyler is a great choice to consider. Guests can get a morning swim in at the outdoor pool, and the spa tub makes for a relaxing end to the day. Rooms feature bonuses like kitchens and sofa beds, along with pillowtop beds and premium bedding.
Wonderful breakfast and happy hour. Staff was extremely friendly. I'd give this an…
The hotel lists its address as 3303 Troup Hwy, but there's no entrance to the property on…
TripAdvisor Traveller Rating: 3.5
From 193 reviews
Enter dates to check prices
Hotel Info: 0800-886-061 (New Zealand Toll Free)from NZ$147
- Studio, 1 Queen Bed with Sofabed
- Suite with Queen Bed and Sofa Sleeper
- Room
- Room
- Penthouse
- Room, 1 Queen Bed, Accessible, Non Smoking
- Second Floor Suite with 2 Queen beds and Sofa Sleeper
- Accessible Queen Bed Suite with Tub
- Suite, 2 Bedrooms
- Second Floor Suite with Queen Bed, Double Murphy Bed and Sofa Sleeper
Recommended hotels
At a glance
Key facts
Hotel size
- This hotel is arranged over 2 floors
- Check-in time starts at 4 PM
- Check-out time is noon
- Express check-out
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
Travelling with others
- Pets allowed *
- Free WiFi in public areas
- Free wired Internet access in rooms
- Free self parking
Other information
- Smoke-free property
Nearby Three Star Tyler hotels
In the hotel
Food and drink
- Free hot/cold buffet breakfast
- Free reception
- Coffee/tea in the lobby
- Barbeque grills
Things to do
- Outdoor pool
- Free use of nearby fitness center
- Spa tub
Working away
- Conference space size (feet) - 680
- Conference space size (meters) - 61
- One meeting room
- 24-hour front desk
- Dry cleaning/laundry service
- Laundry facilities
- Free grocery shopping service
- Free newspapers in lobby
- Safe-deposit box at front desk
- Picnic area
- Fireplace in lobby
In the room
Home comforts
- Climate control
- Air conditioning
- Coffee/tea maker
- Iron/ironing board
Sleep well
- Down comforter
- Sofa bed
- Premium bedding
- Pillowtop mattress
Things to enjoy
- Separate sitting area
Freshen up
- Free toiletries
- Hair dryer
Be entertained
- Pay movies
- Premium TV channels
- Video-game console
Stay connected
- Desk
- Free wired high-speed Internet
Food and drink
- Refrigerator
- Microwave
- Kitchen
- Stovetop
- Cookware, dishware, and utensils
- Dishwasher
- Daily housekeeping
- Access via exterior corridors
Top Tyler hotels
Nearby hotels
Hawthorn Suites by Wyndham Tyler, Tyler's small print
Mandatory fees
Deposit: USD 250.00 per stay
Optional extras
Pets are allowed for an extra charge of USD 100
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.


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- Filed Under
As the season winds down, each area team knows a playoff berth is unlikely in its future.
However, a chance to build momentum heading into 2014 is important, and it starts this week.East Canton (2-6) at Ridgewood (4-4)
Last week's 14-13 loss at Sandy Valley still stings with General head coach John Slusser. ...


text:
Germany WC heroes return to big partyComment on this story
Berlin - Germany's World Cup-winning team returned home to share the country's fourth title with huge crowds of cheering fans on Tuesday.
The team's plane touched down at Berlin's Tegel Airport midmorning after flying low over the "fan mile" in front of the landmark Brandenburg Gate.
Captain Philipp Lahm led the team off the aircraft with the trophy held aloft, to cheers and a chorus of "Football's Coming Home" from fans on the airport's viewing terrace.
He was followed by midfielder Bastian Schweinsteiger, draped in a German flag and sporting a bandage under his right eye, the result of a cut in the 1-0 win over Argentina in the final on Sunday.
From the airport, the team set off for downtown Berlin in a bus painted with the years of Germany's World Cup victories: The previous occasions were in 1954, 1974 and 1990.
The team climbed aboard an open-top truck for the last part of the trip to the Brandenburg Gate, inching its way forward through cheering crowds.
Forward Lukas Podolski posted a selfie with Schweinsteiger and the trophy. He tweeted: "The Cup is in Berlin!!!"
Mario Goetze, who scored the winner in the final, tweeted: "Wow, what's going on here ... AMAZING!"
The "fan mile" started filling up hours before the arrival, with some waiting overnight to get a place at the front.
"This time, thank God, we have the cup with us," Schweinsteiger told ARD television. "It will only sink in for us in the next few days."
The team's plane was about an hour behind schedule, as its departure from Rio de Janeiro was delayed after a luggage truck hit the aircraft and damage to the paintwork had to be inspected.
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text:
- Filed Under
Pavel Datsyuk shook hands on a three-year extension this morning, agreeing to stay with the Detroit Red Wings through 2016-17.
General manager Ken Holland told the Free Press the deal is for $22.5 million, with an annual salary cap hit of $7.5 million. That latter number is especially important, because it matches what team captain Henrik Zetterberg will make in actual salary each year from 2014-15 through 2016-17.
"We're thrilled," Holland said. "We think Pav is one of the best two-way forwards in the world. To know he is committed to us for four more years is a tremendous relief. ...


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- Filed Under
Two Las Vegas-area residents arrested in Iron County last month on drug charges made their initial appearance in federal court Tuesday on charges they intended to traffic the drugs and were carrying firearms at the time of the arrest.
Adrian Antonio Alvarez-Mejia, 25, and Miguel Alonso Rodriguez-Zoto, 22, both of North Las Vegas were arrested on state charges Sept. 2 after an Interstate 15 traffic stop in Iron County led to the discovery of a large amount of drugs and guns.
The federal grand jury issued an indictment last week charging the pair with possessing methamphetamine and heroin with ...


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Betsy, your question was, "With all the publicity telling us about the need to take care of our military people returning with PTSD, armless or legless, why would your congressperson vote against this bill?" You said you were speaking of the most recent Continuing Appropriations Bill. The answer to your question is simple. It's time to stop playing games and face economic music. I dare not speak for Tom McClintock, but my guess is he is hard put to vote "no" on a bill that is said to help our vets.
If you have followed the budgetary shell game you would know that there has been no federal budget since 2009. Simply said, that's illegal. Instead, politicians avoid being held accountable for their flagrant spending by playing fiscal roulette. When the wheel stops, they avoid facing the reality that we have to curb spending by using budgetary gimmicks like calling decreases in spending cuts, continuing resolutions, stimulus packages and sequesters. Oh, and the granddaddy of them all, quantitative easing. For cover they drag out causes celeb such as fire, EMS, police, schools, and now veterans have been added in an attempt to intimidate those who want to stop the game playing and face carnage.
How dare anyone vote against these services? Every time we avoid dealing with this problem the consequences get worse to the point where anything we do will be extremely painful for all of us. Did you hear how Cyprus is handling this problem? (There is speculation Italy is next.) As it was reported in our media this morning, "They are tapping into banks to help solve the problem." The fact is that they are going into the bank accounts of every man, woman, child, business, retirement accounts and summarily extracting between 6 and 10 percent. No discussion, no bargaining, pleading. What's that, did I hear you say that could never happen here?


text:
By On the occasion of our 20th anniversary
Why Do Mexis Like Wrought-Iron Fences?
By Gustavo Arellano
By R. Scott Moxley
By Alfonso Delgado
Women For: OC are Stitching and Bitching
By Courtney Hamilton
Santa Ana River Ready for Its Renaissance
By Joel Beers
By Peter Maguire
Can Tech Ruin the Kim Pham Murder Trial?
By Charles Lam
[. . .]
Are you allowed to call and write me? I worry because you haven't returned either of my calls this week. If there is a problem, just let me know so I won't wonder and be left in suspense.
[. . .]
If you get this around your b-day, then HAPPY B-DAY!
[. . .]
Also, remember if you are allowed to write and call, then communication is a two-way street. If you want to write or call, then do so. I worry that you won't be allowed to or that you will just forget me after a while, so don't let me worry so much, little guy. Keep in touch [smiley face]
[. . .]
Are you allowed to come out next summer to visit me? If so, then when can you come? Please let me know. I am waiting for you to call me because when we last talked you said you would call in 3-4 days. Also, I called you twice after then and I haven't heard from you yet. So, if you get this letter and you haven't called yet, then you can bet that I am concerned.
9/24, 11:50 p.m. (Pacific)
Hi Billy,
It's late. You're undoubtedly asleep by now. Enclosed are the following to keep you briefed on USC football this fall. (I don't want to say 'USC domination' or anything like that because I may jinx 'SC and make them lose to Notre Lame or UCLA.
[. . .]
Note: I am sending you this before I get your letter. I also have not opened up the package. I will do that on my birthday. I will write you right after receiving your letter, also [smiley face].
[. . .]
I hope that you had a great B-day. I really miss you and not spending it out there with you. I can't wait to see you again! Hopefully, at New Years this year.
[. . .]
Somehow, I always find a way to get myself into the strangest positions. Anyways, I try to forget all of that by looking forward to seeing you again. I am praying for you in school and in everything else. Hang in there. Even though you may not always think so, I am here for you to lean on. 2,600 miles is not going to keep me from being there for you, LITTLE GUY-NEVER!! [smiley face]. So smile. And I know that I've got you to talk to also.
[. . .]
I love you. Have a happy day, night, etc. I can't wait to see you!! I hope soon.
When you write me, why don't you write letters this long? I ask you tons of questions in my letters to you that you don't answer. Anyway, I still haven't received your B-day card, but I got your letter yesterday. How is band? How do you feel about your chances to get onto the basketball team? How do you feel about high school now? How do you feel about me not being around anymore? Are you used to it? I figured that after a while, others would get you to forget about me enough to not miss me anymore.
[. . .]
Work on the campaign has been very time consuming. I have done nothing but campaign stuff every day for two weeks now. In fact, between LSAT classes and work, I haven't gone to church once since I've been out here. Speaking of church, how's my favorite church? Has anyone there come up to you and said anything lately? I'm sure they will, considering that I gave Yates my opinion about what I know they're up to. Don't get yourself caught in the middle of a bunch of hypocrites. They are not Christians.
[. . .]
I hope you are doing well in high school. Don't allow yourself to get caught up in the alcohol, trouble-making, sex etc. That is so common in high schools now. It's just not worth it. It may seem like fun, but you will pay for it later, no matter how harmless it may seem now. I can't be there to watch you, and I will not become angry if I learn you have done something bad, so please be honest with me even though I know you don't want to because you think that telling me what you're up to will make me think less of you. I won't. But you've got to trust me, and don't trust anybody who tries to convince you that 'making out,' having sex, doing drugs, drinking, getting into a car with a drunk driver etc is cool. It's not. It's stupid.
[. . .]
I miss you tons. Please, please, please write me when you get this. Send me a letter in a regular envelope, and try to write a longer letter. Just let your pen flow.
Well, it's 10:20 a.m. and I'm here at the Scott Baugh for Assembly campaign headquarters. I just spoke with you a little while ago. I hope that you understand that I wouldn't get angry at you for going to the mall or Reston Town Center. If you were to do something wrong there, I wouldn't be happy, but neither would your parents. Billy, I'm telling you, don't do anything now that you're going to regret later. If you think it's time of us to stop communicating, then the ball is in your court. I know you would say that you want to stay in touch, but I can't keep in touch if you don't want to be honest with me. If you have a reason for not being honest with me, then let's talk about it. You deserve to have your own life and to make whatever choices you wish. You know that I care about you very much. Just look around your room at everything I have bought for you. Think about all that I've done for you. Billy, I don't want to run your life like others who will remain nameless. I just want to have an honest relationship with you. If you feel that is not possible, the decision is yours to make.
Sponsor Content


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Mental retardation (MR) is a heterogeneous condition that affects 2-3% of the general population and is a public health problem in developing countries. Chromosomal abnormalities are an important cause of MR and subtelomeric rearrangements (STR) have been reported in 4-35% of individuals with idiopathic MR or an unexplained developmental delay, depending on the screening tests and patient selection criteria used. Clinical checklists such as that suggested by de Vries et al. have been used to improve the predictive value of subtelomeric screening.
Fifteen patients (1–20 years old; five females and ten males) with moderate to severe MR from a genetics outpatient clinic of the Gaffrée and Guinle Teaching Hospital (HUGG) of the Federal University of Rio de Janeiro State (UNIRIO) were screened with Multiprobe T FISH after normal high resolution karyotyping. No subtelomeric rearrangements were detected even though the clinical score of the patients ranged from four to seven.
In developing countries, FISH-based techniques such as Multiprobe T FISH are still expensive. Although Multiprobe T FISH is a good tool for detecting STR, in this study it did not detect STR in patients with unexplained MR/developmental delay even though these patients had a marked chromosomal imbalance. Our findings also show that clinical scores are not reliable predictors of STR.
Keywords:Developmental delay; Mental retardation; Subtelomeric rearrangements
Chromosomal abnormalities are an important cause of mental retardation (MR) [1]. Most of these abnormalities can be detected by G-banding karyotype analysis, although subtle structural variations are not easily assessed. Most deletions are located near telomeric regions, a common feature in MR patients [2]. Unfortunately, in most patients (60%) the etiology of MR remains unclear [3], despite the use of good quality metaphase preparations in high resolution assays [4].
In subtelomeric regions, the distal segment is shared by many chromosomes while the proximal is larger and shared by a smaller subset of chromosomes [5]. Sequence similarity between non-homologous chromosomes may cause ectopic recombination during meiosis and lead to subtelomeric rearrangements (STRs) [6], with most translocations occurring in these regions [5]. The frequency of STRs in individuals with MR is 4-35% [7], depending on the assays and patient selection criteria used.
Multiprobe T FISH (MT-FISH) [8] is a specific method for detecting STRs in patients with MR who have a normal karyotype; this technique is widely used in this field of investigation and is available commercially. The wide range in the frequency of STR reflects variation in individual responses in this assay, as well as the availability of adequate laboratory infrastructure [9]. These factors must be considered when choosing the appropriate method in studies of STRs.
The primary aim of this study was to assess the usefulness of MT-FISH as a routine diagnostic test for detecting STRs in children and adolescents with early developmental delay, before the onset of MR. A secondary aim was to improve the predictive value of subtelomeric screening in patients selected using the protocol of de Vries et al. [10]. These individuals had evidence strongly suggestive of a chromosomal imbalance, despite a family history of MR.
Materials and methods
Patient selection
Patients were recruited from the genetics outpatient clinic of HUGG-UNIRIO. The cohort consisted of 15 patients (five females and ten males; age range: 1–20 years old) with learning disabilities and/or MR who presented developmental delay. These subjects had a variable family history of learning disabilities, developmental delay or MR and a normal karyotype, as assessed with a high resolution assay. Dysmorphic features, congenital defects or malformations were recorded systematically during clinical examination. An unknown cause of learning disabilities, developmental delay or MR, or uncommon features in known syndromes, were considered as inclusion criteria. Two sets of twins with the same clinical presentation and two second-grade male cousins without similar clinical features were included in the sample. Tests for fragile X syndrome were done in all males and, to exclude other possible causes of MR, the patients were screened for inborn errors of metabolism and underwent serology tests for toxoplasmosis, rubella, cytomegalovirus, herpes virus and syphilis [11]. Subsequently, the clinical criteria of de Vries et al. [10] were applied and a score of 3 was chosen as the minimum for selecting patients for MT-FISH. All parents/guardians of the patients signed an informed consent form prior to participation in the study. Ethical approval was obtained from the appropriate hospital committees. (HUGG – CEP:22/2003; HSP/UNIFESP CEP: 1070/08).
Cytogenetic technique and molecular cytogenetic analysis
Cytogenetic analysis
Cytogenetic analyses done in the Cytogenetic Laboratory at UNIRIO were used to exclude known chromosomal abnormalities. Lymphocyte cultures were established and harvested using standard protocols for high resolution assays. The quality of the metaphase preparations for karyotype analysis and FISH was enhanced by using Cytoclear® (Genial Genetics Upton, Wirral, UK), according to the manufacturer's protocol.
Molecular cytogenetics
STRs were detected using Chromoprobe Multiprobe T System® kits (Cytocell Inc., Banbury, UK) with slight modification to the protocol. Hybridization, washing and staining were done according to standard protocols. The test was repeated if more than two probes could not be scored in the multiprobe device. If one or two probes could not be scored then a specific telomeric probe was used to assess the abnormal result. If an alteration was confirmed, FISH was done in the parents to assess whether the abnormality was inherited. Photographic documentation was used only in abnormal cases.
Table 1 shows the clinical and laboratory findings for the 15 patients. Ten patients had a familial history of MR, eight had an abnormal electroencephalogram, seven had central nervous system abnormalities detected by tomography or magnetic resonance, seven had mild malformations or birth defects, five had abnormal vision and one had dysacusis.
Table 1. Clinical data, complementary exams and familial history of patients
Normal subtelomeric FISH results were observed in 14 cases. A 13q deletion was suspected in one proband of one set of twins (Figure 1), but a specific telomeric probe did not confirm this (Figure 2). The individual concerned was an eight-year-old boy with severe developmental delay who was a compulsive crier when younger and had mild dysmorphic features. He was the first twin born to a young, healthy, non-consanguineous couple with a family history of MR. His brother had similar clinical features but dissimilar results. FISH analysis of their parents revealed no abnormalities. MT-FISH did not detect STRs in any of the patients.
MT-FISH is a precise tool for detecting STRs, but its high cost means that in many developing countries it is first necessary to exclude other more common conditions before choosing this technique. For this reason, we have developed a clinical protocol for investigating the causes of MR [12,13] that can be applied to children suspected of having MR before opting for expensive modern techniques.
Our patients were selected from a large group in which developmental delay was the principal diagnosis and was associated with dysmorphic features and/or malformations. This relationship was initially established in a large screening study in which STRs were found to contribute significantly to unexplained developmental delay and MR with or without a family history of developmental delay or MR [14,15]. In the last decade, several studies using unselected and selected patients have shown that STRs are a prominent cause of MR, especially in idiopathic forms or unexplained developmental delay. Yu et al. [16] reported that the frequency of truly cryptic subtelomeric abnormalities in selected patients was 2.6%. In this study, we examined whether MT-FISH could be used as a routine diagnostic test before the onset of MR. However, this question could not be answered because no STRs were detected in our patients.
Scoring based on clinical criteria has been used in many studies [17-22] to increase the sensitivity of STR detection when MT-FISH is used. De Vries et al. [10] re-examined 29 patients with STRs with regard to their shared characteristics and compared the findings with an MR group without STRs (110 patients). Our group of subjects contained five patients with a low birth weight and nine with a family history of MR. A genetic cause is presumed to underlie half of the cases of undiagnosed patients with idiopathic forms of MR and in many cases there is a family history of MR [12]. Riegel et al. [14] stated that family history was an important selection criterion, especially when MR was associated with dysmorphic features and/or major malformations and growth retardation. As shown here, the number of patients with a low body weight, malformation and a family history was proportionally similar to that reported by de Vries et al. [10]. While the presence of these characteristics and the moderate to severe degree of MR should have increased the likelihood of identifying an STR [10], no STRs were in fact detected. The clinical scores of our patients ranged from four to seven yet no STRs were detected, even though the patients had been carefully selected and were suspected of having a chromosomal anomaly. A similar conclusion was reached by van Karnebeek et al. [23].
Joyce et al. [6] reported one case of STR using MT-FISH that, after a detailed karyotypic review, was found to have semi-cryptic structural anomalies involving a chromosomal imbalance. In the same study, two STRs were found in normal individuals, which suggested polymorphism in subtelomeric regions [24].
A 13q deletion with mosaicism was detected in one of our patients; however, there was no phenotypic correlation with the clinical manifestations [25] and FISH with a specific subtelomeric probe was negative. This case indicates the need to establish a clinical correlation with the cytogenetic findings when an STR is detected, especially if the parents or a specific probe are unavailable.
A non-subtelomeric rearrangement could also explain our negative MT-FISH results. In this case, other techniques such as array comparative genomic hybridization may be useful. Based on our findings, we cannot exclude unknown monogenic disease or multi-factorial conditions as at least part of the etiology of MR and developmental delay in these patients.
In developing countries, there is a need for guidelines for investigating idiopathic MR or unexplained developmental delay in order to establish the best method for a given investigation prior to screening with advanced techniques. MT-FISH is a good tool for investigating the etiology of MR or unexplained developmental delay. However, the cost of this technique in developing countries and the low frequency of STRs mean that the use of MT-FISH may not always be necessary. Finally, clinical criteria were not useful in predicting STRs in this study.
Competing interests
The authors declare that they have no competing interests with the publication of this work.
Authors' contributions
All authors read and approved the final manuscript.
Suely Rodrigues dos Santos was responsible for designing and doing the experiments and Dértia Villalba Freire-Maia provided supervision and general guidance throughout the study. Both authors were responsible for analyzing and interpreting the results and writing the manuscript.
The authors thank Mariluce Riegel for doing the experiments with the specific telomeric probe, Márcia Pimentel for the molecular evaluation of fragile X chromosome and Maria Lúcia C. Oliveira (LABEIM) for assessing the inborn errors of metabolism. Ivonne Banhos provided partial financial support for this work.
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Auber B, Bruemmer V, Zoll B, Burfeind P, Boehm D, Liehr T, Brockmann K, Wilichowski E, Argyriou L, Bartels I: Identification of subtelomeric genomic imbalances and breakpoint mapping with quantitative PCR in 296 individuals with congenital defects and/or mental retardation.
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Pediatrics 2006, 117(6):2304-2316. PubMed Abstract | Publisher Full Text
Council on Children with Disabilities: Identifying infants and young children with development delay disorders in the medical home: an algorithm for developmental surveillance and screening.
Pediatrics 2006, 118:405-412. PubMed Abstract | Publisher Full Text
Riegel M, Baumer A, Jamar M, Delbecque K, Herens C, Verloes A, Schinzel A: Submicroscopic terminal deletions and duplications in retarded patients with unclassified malformations syndromes.
Hum Genet 2001, 109:286-94. PubMed Abstract | Publisher Full Text
Baker E, Hinton L, Callen DF, Altree M, Dobbie A, Eyre HJ, Sutherland GR, Thompson E, Thompson P, Woollat E, Haan E: Study of 250 children with idiopathic mental retardation reveals nine cryptic and diverse subtelomeric chromosome anomalies.
Am J Med Genet 2002, 107:285-93. PubMed Abstract | Publisher Full Text
Yu S, Baker E, Hinton L, Eyre HJ, Waters W, Higgins S, Sutherland GR, Haan E: Frequency of truly cryptic subtelomere abnormalities - a study of 534 patients and literature review.
Clin Genet 2005, 68:436-41. PubMed Abstract | Publisher Full Text
Clarkson B, Pavenski K, Dupuis L, Kennedy S, Meyn S, Nezarati MM, Nie G, Weksberg R, Withers S, Quercia N, Teebi AS, Teshima I: Detecting rearrangements in children using subtelomeric FISH and SKY.
Am J Med Genet 2002, 107:267-74. PubMed Abstract | Publisher Full Text
Dawson AJ, Putnam S, Schultz J, Riordan D, Prasad C, Greenberg CR, Chodirker BN, Mhanni AA, Chudley AE: Cryptical chromosome rearrangements detected by subtelomere assay in patients with mental retardation and dysmorphic features.
Clin Genet 2002, 62:488-94. PubMed Abstract | Publisher Full Text
Novelli A, Ceccarini C, Bernardini L, Zuccarello D, Caputo V, Digilio MC, Mingarelli R, Dallapiccola B: High frequency of subtelomeric rearrangements in a cohort of 92 patients with severe mental retardation and dysmorphism.
Clin Genet 2004, 66:30-38. PubMed Abstract | Publisher Full Text
Baroncini A, Rivieri F, Capucci A, Croci G, Franchi F, Sensi A, Battaglia P, Aiello V, Calzolari E: FISH screening for subtelomeric rearrangements in 219 patients with idiopathic mental retardation and normal karyotype.
Eur J Med Genet 2005, 48:388-96. PubMed Abstract | Publisher Full Text
Rooms L, Reyniers E, van Luijk R, Scheers S, Wauters J, Kooy RF: Subtelomeric rearrangemnts in the mentally retarded: a comparison of detection methods.
Hum Mutat 2005, 25:513-524. PubMed Abstract | Publisher Full Text
Palomares M, Delicado A, Lapunzina P, Arjona D, Amiñoso C, Arcas J, Bermejo AM, Fernández L, López Pajares I: MLPA vs Multiprobe T FISH: comparision of two methods for the screening of subtelomeric rearrangements in 50 patients with idiopathic mental retardation.
Clin Genet 2006, 69:228-233. PubMed Abstract | Publisher Full Text
van Karnebeek CDM, Koevoets C, Sluijter S, Bijlsma EK, Smeets DFMC, Redeker EJ, Hennekam RCM, Hoovers JMN: Prospective screening for subtelomeric rearrangements in children with mental retardation of unknown aetiology: the Amsterdam experience.
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Ballif B, Kashork CD, Shaffer LG: The promise and pitfalls of telomere region-specific probes.
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Pfiffer RA, Ott R, Gilgenkrantz S, Alexandre P: Deficiency of coagulation factor VII and X associated with deletion of a chromosome 13(q34). Evidence from two cases with 46, XY, t(13;Y)(q34;q11).
Hum Genet 1982, 62:358-60. PubMed Abstract | Publisher Full Text


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Don't miss out on our expanded calendar of general-interest and family-friendly events
POSTED: 1:30 a.m. HST, Aug 13, 2010
Sixth Annual Remodel It Right Expo, presented by the Building Industry Association of Hawaii (BIA-Hawaii) with the theme "Remodel It Right, Remodel It Right Green"; products, services and trends in sustainable living. 5-9 p.m. today, 10 a.m.-9 p.m. tomorrow and 10 a.m.-4 p.m. Sunday, Hawai'i Convention Center, 1801 Kalakaua Ave. $5 for adults, free for children 12 and under with paid adult, $7 three-day pass, $2 Senior Sunday for 55 years and older with ID. www.biahawaii.org
Waimanalo Country Fair, with rides, games, food, vendors. 6 p.m. to park closing today, noon to park closing tomorrow and Sunday, Waimanalo Beach Park. Free admission (wristbands for rides available at Walmart). www.ekfernandez.com
The 11th Annual Te Manahua Maori Cultural Competition with song and dance competitions will include the haka (male posture dance), poi (a graceful dance with a twirling ball on the end of a string) and fancy kahahu (attire). Haka Hard and Poi-e Competition, 6 p.m. today at Hale Kuai stage; Maori Performing Arts Competition, 9 a.m. tomorrow in the Pacific Theater. Polynesian Cultural Center, 55-370 Kamehameha Highway. $10 for ages 16 and older; $6 for ages 5-15; free for annual pass holders, full-day ticket holders and keiki 4 and younger. 293-3333, www.polynesia.com
Bon dance season continues with dances 7 p.m. today and tomorrow at Soto Mission of Hawaii-Shoboji, 1708 Nuuanu Ave., 537-9409; and 7:30 p.m. today and tomorrow at Pearl City Hongwanji Mission, 858 2nd St., 455-1680. On Maui: 7 p.m. tomorrow at Kahului Jodo Mission, 325 Laau St., 244-0066. On the Big Island: 7 p.m. tomorrow at Kona Koyasan Daishiji Mission, Holualoa, 324-1741; 8 p.m. tomorrow at Hamakua Jodo Mission, 775-0965; and 8 p.m. tomorrow at Hilo Higashi Hongwanji, 216 Mohouli St., 935-8968. On Kauai: 7:30 p.m. today and tomorrow at West Kauai Hongwanji, Koloa, 338-1537.
Celebration of Don Ho, presented by "Al Waterson and You." features performers from Ho's showroom throughout the years in recognition of Ho's birthday. 6-9 p.m., Don Ho's Island Grill, Aloha Tower Marketplace. Free. All ages.
Shaquille O'Neal's All Star Comedy Jam features one of the Original Kings of Comedy, D.L. Hughley, along with Aries Spears, known for impersonations of Jay-Z, LL Cool J and O'Neal himself; Charlie Murphy, older brother of actor-comedian Eddie Murphy; and DeRay Davis. 8 p.m. (doors open 7 p.m.), Blaisdell Arena, 777 Ward Ave. $35-$100, $125 VIP. 800-745-3000, www.ticketmaster.com
"Try Jah Love Tour" is a fundraiser for Help the Hawaii Homeless featuring guest artists Christafari, Isouljahs, White Lines and SoulVibe. 10 p.m. (doors open at 9 p.m.), Pipeline Cafe, 805 Pohukaina St. $10 in advance, $15 at the door, $30 VIP, for ages 18 and older. 877-714-7668, www.pipelinecafehawaii.com
2010 Pulama 'o Waimea: Waimea Valley commemorates four years of Hawaiian stewardship with hula, Hawaiian arts and crafts, keiki games, entertainment, Hawaiian food, guided tours of the valley and more. 9 a.m.-5 p.m., Waimea Valley, 59-864 Kamehameha Highway. $5-$13. At 6 p.m. there will be live music followed by a 7 p.m. screening of "Mighty Uke"; $10, $8 pre-sale tickets available at Waimea Valley gift shop Ku'ono Waiwai until today. 638-7766, www.waimea valley.net
Surfrider and Barefoot Wines Beach Cleanup and Celebration, open to volunteers to keep Hawaii's beaches "barefoot friendly." 10 a.m.-noon, beach cleanup at Ala Moana Beach Park (look for the Surfrider tent by the road in front of Magic Island); 6-8 p.m., celebration for ages 21 and older at Tiki's Grill & Bar, 2570 Kalakaua Ave. Free. RSVP: BarefootBeachRescue.com
The Crafters Clearance Sale & Rubberstamp/ Scrapbook Expo, craft supplies and merchandise. 10 a.m.-4 p.m., Hawaii Suites, Blaisdell Center, 777 Ward Ave. Free. 551-3769
Science Family Fun Day: "Climate Change," for students and parents to explore the scientific and cultural impact of global warming with hands-on activities, interactive stations and more. 10 a.m.-4 p.m., Bishop Museum, 1525 Bernice St. $12.95-$17.95; free for members, children ages 3 and under. 847-3511, www.bishopmuseum.org
Youth Speaks Hawaii, a Second Saturday Monthly Slam and Open Mic. 3 p.m., the ARTS at Marks Garage, 1159 Nuuanu Ave. Free. 521-2903, www.artsatmarks.com
Hawaii Inter-Island Community Drum Circle, hosted by Arthur Hull and his training group. Bring your drums and percussion instruments, no musical experience needed, and enjoy a rhythmical afternoon. 3-5 p.m., Camp Mokuleia, 68-729 Farrington Highway. Free. 831-458-1946, www.drumcircle.com
Pearl City Cultural Center Jazz Festival, benefit for the Royal Hawaiian Band Music Society and the Pearl City Cultural Center, featuring the Honolulu Jazz Quartet with John Kolivas, Tim Tsukiyama, Adam Baron and Dan Del Negro; Rhythm Summit with Kenny Endo, Noel Okimoto and Dean Taba; from Japan, jazz trumpeter Eric Miyashiro; and the PCCC Jazz Festival Big Band. 6 p.m., Pearl City Cultural Center, 2100 Hokiekie St. $20-$25, tickets available at Good Guys Music (Kapahulu) and Music Center of Hawaii (off Ward Avenue). 454-5657
The 70s Nightclub Reunion VIII is back, featuring musical groups Greenwood, Asian Blend, Glass Candle, Power Point and Golden Throat with Nohelani Cypriano, and emceed by Tiny Tadani. 7:30 p.m.-12:30 a.m., Ala Moana Hotel, Hibiscus Ballroom I & II. $40, $50 reserved seating. 944-4330, 70snightclub reunion.com.
The Hawaiian Elvis -- Aloha from Hawaii Show, marking the anniversary of Elvis Presley's death on Aug. 16, 1977, with impersonator Bill "Haupe" Burgher. 7:45 p.m., Pagoda Hotel, International Ballroom, 1525 Rycroft St. $28-$64 (kamaaina rates available). 381-4353, thehawaiian elvis.com
Verdi's "Requiem," featuring the Junge Kammerphilharmonie Freiburg orchestra in its last performance on its first tour of the United States. 8 p.m., Blaisdell Concert Hall, 777 Ward Ave. $20-$25 suggested donation. 524-0815, ext. 257; www.oahuchoral.com
The All Star Comedy Showcase features national stand-up comedian Shawn Felipe, local television personality David Lee, Jose Ver, Paul Kane and Hawaii's longest-running improv group, On the Spot Improv. 8-10 p.m., Aloha Lounge, Aloha Tower Marketplace, second floor. $5. 224-7585, www.otsimprov.com
"Whitewash," Bank of Hawaii Family Sunday, celebrating the exhibit "Men in Lace" with arts activities, a Lace Costume Contest at noon, and screenings of "Pirates of the Caribbean: At World's End" at 11:10 a.m. and 2 p.m. Activities 10 a.m.-5 p.m., Honolulu Academy of Arts. Free. 532-8700, www.honoluluacademy.org
28th Annual Hawaiian Slack Key Guitar Festival honors Gabby Pahinui, Atta Isaacs and other slack-key greats with performances by Ledward Kaapana, Dennis Kamakahi, George Kuo, Brother Noland, Makana, David Kahiapo, Dwight Kanae, Bobby Moderow, Jeff Peterson, Stephen Inglis and more. Noon-6 p.m., Kapiolani Park. Free. www.slackkeyfestival.com
The Art of the Ukulele with Roy Sakuma features Sakuma, recognized as Hawaii's foremost ukulele teacher for more than 30 years. 2 p.m., Kaimuki Public Library, 1041 Koko Head Ave. Free. 733-8422
"Hana -- The Flower II," presented by choreographer and modern dance artist Keiko Fujii, is based on the legend of Amida Pond and themed around the pressures of modern society, fusing traditional Japanese dance elements with modern movement. 2 p.m., Kennedy Theatre, University of Hawaii at Manoa, 1770 East-West Road. $18-$30. 956-7655
"A Night of Aloha: Hawaiian Mele Night" is a family event with a Hawaiian theme, featuring Hawaiian music, make-your-own Hawaiian sundae and shave ice. Hawaiian attire suggested. 6-7:30 p.m., International Baptist Church, 20 Dowsett Ave. Free. 595-6352
WWE presents Raw World Tour with John Cena, Randy Orton, Mark Henry, Sheamus, Evan Bourne, The Miz, The Hart Dynasty, Chris Jericho, Ted DiBiase, Maryse, Eve, The Nexus. 7:30 p.m., Blaisdell Arena, 777 Ward Ave. $15-$60. 800-745-3000, www.ticketmaster.com
Comedian Steve Byrne, known for his high energy and physical style of comedy. 8 p.m. (doors open 7 p.m.), Pipeline Cafe, 805 Pohukaina St. $20, $40 VIP. 877-714-7668, www.pipelinecafehawaii.com
The Joy of Sake marks 10 years and a second year at the Honolulu Academy of Arts with more than 250 sake samples to taste and pair with plates from Honolulu restaurants. 6-8:30 p.m., Honolulu Academy of Arts, 900 S. Beretania St. $80, $150 VIP. 532-8700, www.honoluluacademy.org
"Teen City -- Back to School Bash," hosted by Ekolu and Josh with James Coles and United DJs. 8-11:45 p.m., Waianae Chop Suey, 86-120 Farrington Highway. $15, all ages. 479-3008, firstname.lastname@example.com
"Friday Night Comedy in Aiea," presented by improv troupe On the Spot, features a rotating cast of stand-up comics and improv groups in a show appropriate for all ages. 7:30 p.m. Fridays at Rosalie Woodson Dance Academy in the Aiea Village Square, 99-153 Moanalua Road, Room D. $5. 224-7585
Twilight tours at Honolulu Zoo let visitors see what happens there when the gates close and the sun sets. Recommended for adults and children age 4 and up. Evening hours: 5:30 to 7:30 p.m. Fridays and Saturdays, $8-$14; reservations recommended. Corner of Kalakaua, Kapahulu and Monsarrat avenues in Waikiki. 971-7195, www.honolulu zoo.org.
"Dinosaurs!" with animatronic dinosaurs and hands- on activities; also featuring the Pearlridge Safari Train ($3). Mall hours through Sunday at Pearlridge Center. Free. 488-0981, www.pearlridge online.com
"Torn from Home: My Life as a Refugee" takes young visitors and adults on a hands-on journey into the lives of children who have left homes in regions of conflict. 9 a.m.-1 p.m. Tuesdays-Fridays, 10 a.m.-3 p.m. Saturdays-Sundays through Oct. 16 at Hawaii Children's Discovery Center, 111 Ohe St., Kakaako. $6-$10. 524-5437, www.discovery centerhawaii.org
Free family films continue during the summer at the Regal Dole Cannery Stadium. Films are rated either G or PG, and screenings start at 10 a.m. Tuesdays and Wednesdays, with two movies shown simultaneously. Seating is first-come, first-served, and tickets are available at the box office the morning of each screening. This Tuesday and Wednesday: "Charlotte's Web" and "Imagine That." Aug. 24 and 25: "Jonah: A Veggie Tales Movie" and "Cloudy With a Chance of Meatballs."
"Art in the Park" is a drop-in art program that lets children explore a variety of art media with three open-ended activities. 11 a.m.-noon Wednesdays at the Hawaii Children's Discovery Museum, 111 Ohe St. $3 ($1 with paid admission to museum). 524-5437, www.discoverycenterhawaii.org
"E Ku Ana ka Paia: Unification, Responsibility and the Ku Images" has the Bishop Museum, British Museum and Peabody Essex Museum partnering to bring together the three largest Ku images in the world for a historic exhibition, through Oct. 4. Bishop Museum, 1525 Bernice St., 9 a.m.-5 p.m. Wednesdays-Mondays. $7.95-$17.95; free for members, children ages 3 and under. 847-3511, www.bishop museum.org
"Ha: Breath of Life" is a Polynesian floor show telling the story of Mana, who matures through young love, respect and responsibility. To mark its first anniversary, this month the Polynesian Cultural Center offers Hawaii residents a value package of buffet dinner, show and souvenir poster, valued at more than $60, for $25. 7:30 p.m. nightly (except Sundays) at the PCC. 293-3333, www.polynesia.com


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Seymour's Sandy Cohen (1) pulls down a rebound during March sectional semifinal game against Pulaski.
- Filed Under
Seymour boys basketball standout Sandy Cohen received a scholarship offer from Marquette on Saturday, just the latest in a line of schools lining up for the junior guard.
"All of this has happened so fast," Seymour coach Jon Murphy said. "We are just going to take a little time to process it. I think he will play out the AAU (season) this spring.
"He is probably going to get it down to a couple and make a decision. Probably sometime this fall, before the season." ...


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- Filed Under
While the cost of estate planning might seem expensive, the cost of filing probate in the absensce of a will is far more prohibitive, according to the president of the Guam Bar Association, Cynthia Ecube.
Property owners can avoid leaving their relatives with a lengthy and expensive probate case after they pass away.
While every case will be different, a lawyer will be able to give the best advice, Ecube said. ...


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Mrs. Danu, you should try to be easier on yourself. Congratulate yourself for continuing to run at all despite the difficulties that have been going on in your life. Why don't you make it a goal to just run the race and not beat your time (especially by 10 minutes)?
Life will get better. You are on the low curve of the rollercoaster. Pretty soon you will be on the high and ready to tackle another race.
Good luck!
I haven't run a half yet, but it sounds like you've prepared to the best of your ability considering the circumstances. At this point it sounds like you need to take some time to do some mental preparation. Tell yourself you can do it, you've done it before. And it's okay to change your goal. Instead of a time goal, what about a "just to finish" goal? Best of luck to you!
5k 33:07 | 13.1 2:39:12
I feel for your situational distress, but have no advice for you on that front.
In terms of your concerns about whether you're ready for your race, I'd say you're going to be ok even if you might not PR it. It could be that the reason you're struggling with your tempo run and speed work is because you're running your easy runs too fast. Try making your easy runs easy to leave yourself fresher for the fast stuff. This something I have to really work on myself so I've felt the same way.
Edited to say that since it's in 7 days make sure that you try to make the runs in your taper count by not over running them so that you go into the race with fresh legs.
How does your training this year compare to last year for this race? What do your actual training paces predict for a finishing time? What was your longest run at goal HMP?
I had a goal race in which my training didn't go as planned. I was miserable, and stressing out over the race, and very upset that I didn't do everything that I had planned. I compared my training to that of my previous PR, and although I didn't meet all my training goals, I realized I was much better trained than my previous race. This turned my apprehension into optimism, which resulted in negative splits and a 6 minute PR. My goal was 5 minutes, so if you look at where you are as opposed to where you wanted to be, you should have a pretty good idea as what to expect. Good luck!
Running your easy paces too fast is why you missed your paces on your workout days. You don't WANT to CRUSH your easy days. As a result you probably missed your paces on your quality work because of running easy days too hard. While a lot of people think that's not ideal for training, my experience has been that anything that takes a lot of you will still help you improve as a runner. So I wouldn't worry too much.
No training happens in a bubble, we all have our personal and professional stressors that impact training from time to time.
Also, I doubt you are truly overtraining on a half-marathon program. The human body is pretty resilient, and I bet if you take a couple of days off right before the race and otherwise reduce mileage you'll be right as rain. Cumulative fatigue is a GOOD thing in distance training. That's what the taper is for.
One thing I would caution you against, don't put too much stock in what Smart Coach says your Goal Pace should be as a result of your training. It's hogwash. If you have a recent shorter distance race, use a race predictor based on that time. Then, if you feel good in the last 3 miles, empty the tank.


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