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The history of Cartier Watches goes back over a century, always in tune with the unchanging benchmark of watchmaking creativity and excellence. The...
WatchElse! The first only mobile watchmaking magazineIssue n7 January 2012 Dear Readers, We would like to thank you for having downloaded the first...
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The company nabs the vice president of sales and retail from Tag Heuer, as it reportedly gears up to launch an iWatch later this year.
The mechanical watch with tech features -- a rarity in an all-digital smartwatch world -- is expected by year's end, with more details on pricing and features slated for the fourth quarter.
The smartwatch is Apple's first product to focus on design first and technology second, says analyst Gene Munster. So how long might the new watch take to fully catch on with consumers?
Before it's even on the market, the watch wins gold in the 2015 iF Design Awards. The next challenge will be to see if it can win the battle for consumers' hearts and dollars.
Shooting stars with some cash to burn should check out this set of ridiculously expensive Pac-Man and Space Invaders timepieces featuring authentic moon dust and fragments of Apollo 11.
Road Trip 2011: Visitors to the Patek Philippe Museum in Geneva can wander among dozens and dozens of the world's most beautiful watches. But the collection also features an archive of beautiful timepieces dating back to the 16th century.
Luxury watchmaker Vianney Halter creates a breathtaking tourbillon watch based on "Star Trek: Deep Space 9."
The new H2 watch from the Hydromechanical Horologists uses a unique bellows to pump liquid around the dial to indicate hours.
Swiss watch company Tissot has launched an application that lets consumers try on various styles at home--digitally, in 3D.
Swiss watchmaker TAG Heuer, which long ago branched out from its core business, announces an Android-based smartphone inspired by GT race cars.


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Video: Mudhoney rocks Easy Street Records in West SeattleApril 1, 2013 at 9:53 pm | In West Seattle news, WS culture/arts | 2 Comments
That's a bit of Mudhoney's in-store show tonight at Easy Street Records in The Junction (if you want to jump ahead, the music starts around 1:40 in) – marking the release of the band's new album Vanishing Point, along with the 25th anniversaries of Easy Street, Sub Pop Records, and Mudhoney itself. Fans lined up in the early-evening sunshine along SW Alaska …
… filled the California SW sidewalk (and then some) by showtime -
… as well as every bit of spare space inside too:
Just steps away from Easy Street, Mudhoney played West Seattle Summer Fest back in 2009.
2 Comments
Great show! Thank you Mudhoney and East Street! We are so lucky to live in West Seattle!!
Comment by Staceydev — 6:40 am April 2, 2013 #
I love Easy Street!!!!!
Comment by k — 8:00 am April 2, 2013 #
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Tactical Ripstop Pant - Dickies
Dickies Tactical Ripstop pant, engineered to work as hard as the officers who...
A 24-year-old man accused of shooting a Detroit police officer in the leg is in custody after an hours-long search, Police Spokesman John Roach said last night.
The man was found inside a home in the 6400 block of Van Court about 7:30 p.m. The gun used to injure the officer has not been recovered, Roach said.
Read Full Story at the Freep.com


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St. Louis, MO (SportsNetwork.com) - Martin Brodeur posted his first shutout as a member of the Blues in St. Louis' 3-0 win over the Colorado Avalanche on Monday.
Brodeur, who spent his first 21 seasons with the New Jersey Devils, has tallied the most shutouts in NHL history over the course of his prolific career and made 16 saves to earn number 125.
Dmitrij Jaskin, Chris Butler and Vladimir Tarasenko all scored for the Blues, who ended a four-game skid with a solid defensive effort.
"I think he's gotten more comfortable here," Butler said of Brodeur. "I think tonight was an awesome performance by him."
Semyon Varlamov allowed all three goals on 25 shots as Colorado's three-game winning streak was snapped.
"It's clear that we need to do things differently," Avalanche head coach Patrick Roy said.
Neither team was able to convert in the opening stanza as Colorado held an 8-5 shot margin after twenty minutes of play.
It didn't take long for St. Louis to start the scoring in the second period as Jaskin's shot from the right circle went under the pad of Varlamov for a Blues lead 28 seconds into the frame.
Butler took a dish from T.J. Oshie off the cycle, charged in on net from the left circle and finished the play by elevating a backhander over Varlamov's shoulder for a 2-0 game at 4:30 of the second.
Varlamov denied Maxim Lapierre's one-timer point blank early in the third to keep it a two-goal game.
Tarasenko intercepted a Colorado pass in the offensive zone and capped the scoring on a quick wrister with 4:35 left in regulation.
Blues forward Paul Stastny finished with two assists ... Varlamov stopped all
20 shots as Colorado shut out the Blues. 5-0, on Dec. 22 ... Colorado
forward Alex Tanguay played in his 500th career game ... The Blues improved
to 15-4-1 when scoring first this season ... Butler scored his first goal as
a member of the Blues. The veteran defenseman spent his six previous seasons
with Buffalo and Calgary before signing with St. Louis in July ... Avalanche
forward John Mitchell took charge of the physical side of the contest with a
game-high seven hits ... The two teams will conclude their season series at
Scottrade Center on Jan. 19.


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MESA COUNTY, Colo. (KKCO) - The Bubonic plague has been found in Mesa County in the past, and it can be transmitted to humans, causing serious illness and even death.
This mass-killer of the late 1300's now runs on a seven year cycle, and even though it's hardly a death sentence anymore 'the plague' is still a relevant disease.
Between 2005 and 2006 about 140 rodents were tested for the plague in Mesa County. Twenty two of them turned up positive for the disease. Seven years later it's something the community should watch out for as the plague cycles naturally in wildlife. It's caused by flea bites, and once every few years it breaks out among animals, who can in turn, transmit it to humans.
Symptoms of the plague in humans include a sudden onset of fever and chills, severe headaches, muscle aches, nausea, vomiting and exhaustion. Seeing a doctor immediately after experiencing these symptoms should prevent a life-threatening situation.
Mesa County Health Department officials say a dog can carry the plague but can't physically be affected by it. A cat, however, can be physically affected by it and can also spread it to people. Officials say it's important to call your vet if your pet has any sign of fleas in order to protect yourself and your animal.
If you see dead rodents on your property, you're also asked to call officials at the health department so they can test the animals for the plague.
KKCO firmly believes in freedom of speech for all and we are happy to provide this forum for the community to share opinions and facts. We ask that commenters keep it clean, keep it truthful, stay on topic and be responsible. Comments left here do not necessarily represent the viewpoint of KKCO 11News.powered by Disqus


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I'm a Product Designer from Canada working mostly on web and native applications. Lately I've been writing more and more front-end code and couldn't be happier with how this influences design decisions and workflow. I've been lucky enough to work on projects for companies such as Red Bull and Oracle, as well as various young start ups and studios. Currently I'm making cool stuff at Facebook and learning a ton while I'm at it. Aside from work, I'm usually playing in bands, building things with wood, and stuffing my face with burritos.
Since 2009 I've worked with various companies in Canada, Germany, and The United States. I spent some time working with a few start ups and small companies such as Projecturf, Fileboard, and Appuous and at one point launched my own Mac application called Drip. I spent one and a half years in Berlin working with some amazing people at Edenspiekermann. I'm a graduate of Graphic Design from Cambrian College of Art and Design.


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Been here? Rate It!
The Bass Performance Hall with 48 Ft. Angels
This is one of the crown jewels of dowtown Fort Worth and has become of the most recognized grand facades. Outside the building graces such beautiful 48 foot angels were sculpted by Marton Varo from Texas limestone. I have seen these beautiful sculptures many times in a photographs, which I can relate to as being a favorite to photograph. They are stunning and do the city proud.
These angels are part of the spectacular "The Nancy Lee and Perry R. Bass Performance Hall" that seat 2,056 in a multipurpose center, which is designed by David M.Schwarz/Architectural Services, Inc. with acoustics by Jaffee, Holden, Acoustics, Inc., of the classic European opera house form. The beautiful 80-foot diameter great dome, artfully painted by Scott and Stuart Gentling, tops the Founders Concert Theater.
- Architecture
- Theater Travel
Catch The Shows At The Bass Performance Hall
Our first opportunity to experience a performance at BASS HALL was to see the semi-staged version of SHOW BOAT for our anniversary. Since then, we've enjoyed many classic concerts presented by the Fort Worth Symphony here.
Although the building appears to be much older, it opened for its first event in May of 1998. The two immense 48 foot tall angels decorating the exterior were sculpted in limestone by Marton Varo. I think they are absolutely gorgeous!
'Diana', a gilded bronze statue by Augustes Saint Gaudeas (1928) beautifies the lobby (pics 2- #3.) She was a gift of Amon G. Carter Foundation in memory of Bayard H. Friedman (1926-l998).
Bass hall is designed in the manner of the classic European opera houses with over 2,000 seats. A great dome, which is 80 feet in diameter, crowns the interior of the theatre. It features billowy blue clouds surrounded by a ring of feathers (pic #4)painted by Scott and Stuart Gentling.
A tiny gift shop is located in the lower level (pic #5). Bass Hall sits within Ft. Worth's cultural district, which is the third largest in the nation.
FYI: This attractive performance hall is named in honor of Nancy Lee and Perry R. Bass.
- Music
- Arts and Culture
- Theater Travel
Culture and Cowboys
Bass Hall attracts performers from around the globe.
So if you think of cows when you think of Fort Worth...think of classy cows.
Modeled after Europe's great concert halls and New York's Carnegie Hall, Bass Hall is the crown jewel of downtown Fort Worth's renaissance. Open since 1998, it is named for Nancy Lee and Perry R. Bass, the billionaires who deserve much of the credit for downtown's renovation. Besides its superb acoustics, Bass Hall has extraordinary architecture. Two huge limestone angels loom high above the street, holding golden trumpets.
We went there to see a performance for Khalil's birthday. It was a great experience.
- Arts and Culture
Bass Performance Hall
Don't get the idea that culture in Fort Worth is all of the country and western variety - it has a rich arts scene as evidenced by the existence of one of the country's finer performing arts center - the Bass Performance Hall, home to symphonic, operatic, and ballet performances.
- Music
Bass Performance Hall
You can't really say you have experienced Fort Worth until you have visited Bass Hall. The exterior, with its enormous angels is breathtaking, and the splendor continues inside.
During my visit we attended a free event sponsored by the Star-Telegram called Great Women Writers of Fort Worth. It was a very enjoyable interview, Q&A and book-signing session featuring Liz Smith, Sandra Brown, and Sally Jenkins. I gather that they put on these types of events quite often.
I highly encourage you to find any excuse you can to attend some sort of performance at Bass Performance Hall.
- Architecture
- Music
- Theater Travel
If you have the opportunity,...
If you have the opportunity, go see what's happening at the Bass performance hall. During my visit I had the unbelievable luck to be there while the van Cliburn competition was taking place!!! The building is beautiful, the acoustics wonderful, the experience fantastic!
Western Facade of Bass Performance Hall
The celestial hierarchy annunciate the grandness of the philharmonic euphony within the palisade of white batholite.
- Arts and Culture
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text: Tamerlan's Cause of Death Revealed Funeral home owner reads from death certificate By John Johnson, Newser Staff Posted May 4, 2013 5:34 AM CDT STORY COMMENTS (65) (Newser) – The death certificate of Tamerlan Tsarnaev apparently will hold no surprises. While Massachusetts officials have yet to release it publicly, the owner of the Worcester funeral home with his body said it lists the cause of death as "gunshot wounds of torso and extremities" and "blunt trauma to head and torso," reports CNN. That gibes with what authorities have previously said: Tamerlan was hit by police bullets and run over by Dzhokhar as the younger brother fled their shootout in a stolen SUV. The certificate lists the time of death as 1:35am on April 19, reports AP. The funeral home, meanwhile, is still striking out in finding a cemetery willing to take the body. "There's a fear there," owner Peter Stefan of the Graham Putnam and Mahoney funeral parlor tells WBZ. "Will people want to go to the cemetery, or will people be upset that somebody who's a terrorist will be buried next to their Uncle Freddy." IA 2010 photo of Tamerlan Tsarnaev. (AP Photo/The Lowell Sun, Julia Malakie) Harry Lindner of Worcester waves an American flag on Main Street as he joins other protesters across the street from the Graham, Putney & Mahoney Funeral Home. (AP Photo/Worcester Telegram & Gazette, Steve Lanava) This Monday, April 15, 2013 file photo provided by Bob Leonard shows bombing suspects Tamerlan Tsarnaev, 26, center right in black hat, and his brother, Dzhokhar A. Tsarnaev, 19. (AP Photo/Bob Leonard, File) ADVERTISEMENT(Click Prev or Next to continue viewing images.) « Prev« Prev | Next »Next » Slideshow Associated Press (Source Grid ») CNN (Source Grid ») WBZ 4 (Source Grid ») Crime & Courts • US death certificate • Boston Marathon bombing • Dzhokhar Tsarnaev • Tamerlan Tsarnaev CLICK BELOW TO VOTE 34% 14% 29% 8% 3% 12% RETURN TO THE STORY To report an error on this story, notify our editors.


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Motorola ships RAZR in Mother's Day purple
updated 12:30 pm EDT, Tue May 1, 2007
Moto RAZR Mother's Day
Kicking off the Mother's Day holiday, Motorola today released its MOTORAZR Purple V3i clamshell phone. The deep, metallic color is specially timed for the event and is the first variant of any Motorola phone to be sold only through the cellphone maker's own store.
The phone is a near match to the standard V3i, including the 1.23-megapixel camera, Bluetooth, and music playback. Unlike carrier phones, however, the purple RAZR is sold unlocked and works with any GSM-based cell provider such as AT&T or T-Mobile. A single phone sells for $240, though two will sell together at a discounted $384.


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Donegal, Norvelt post offices may face service-hour cuts
Sarah Harkcom said her desire to keep the Donegal Post Office up and running is, in part, about preserving a slice of her family's history.
Harkcom's late, great-grandmother, Sarah K. Hays, was once postmistress at the small, brick facility perched along Main Street in the borough, as was her late aunt, Vera Reddon.
In addition, Harkcom's late mother, Hilda Snyder, served as postmistress there from March 31, 1951 to May 20, 1977.
"That office has been a big part of my family's life," said Harkcom, president of Donegal Borough Council.
It's one reason why Harkcom said she is concerned that weekday window service hours at the borough office might be reduced from eight to four hours pending analysis of a survey recently conducted by the U.S. Postal Service.
She is also worried that such a reduction in service there could affect the office's business and marketing value to the Laurel Highlands, she said.
"We need a full-service post office here in Donegal," Harkcom said. "A lot of area businesses have post office boxes here, so there is that Donegal recognition.
"We've marketed this area as Donegal — Gateway to the Laurel Highlands. You can go anyplace in the Laurel Highlands from our (PA) turnpike exit here."
That means many more people than just local customers make use of the office to purchase stamps and conduct other transactions before traveling elsewhere, Harkcom said.
"A lot of people from Ligonier stop and do business at Donegal Post Office on their ways to work in Pittsburgh," she said. "If the hours at the post office are reduced or, if the office closes, those businesses which have their post office boxes will have to move them to the (post) office in Acme."
Survey prods change
Donegal-area recipients of the survey were asked to choose between reduction of hours at the office, delivery service through a rural carrier, switching to a village post office located at a local business with longer hours or transferring services to another post office.
The results will be revealed and discussed by Postal Service officials at a public meeting to be held at 6 p.m. Nov. 28 at Donegal Community Center at 113 Community Center Lane.
A similar meeting is scheduled for Feb. 15 in Norvelt, according to Tammy Gregg, the officer-in-charge of the Norvelt Post Office, where it appears window service may drop from eight hours a day to six, Gregg said.
Tad Kelley, postal service spokesman, said the service announced in 2011 that it would study numerous small post offices across the nation for possible closure.
The study was prompted by mounting financial losses and the lack of Congressional legislation to change the service's business model to better conform with shifting demand due, in part, to evolving technology, Kelley said.
"Community meetings were held throughout the year and strong concerns against closing offices were heard from our customer, legislative and stakeholder communities," Kelley said.
This spring, the postal service announced a new strategy — the Post Office Structure Plan or POST plan — to keep smaller post offices such as the one in Donegal open, but with "modified window hours."
"This plan can effectively keep 13,000 small offices open with modified hours," Kelley said.
Out of those 13,000 post offices targeted for such restructuring by the U.S. Postal Service, 859 are in Pennsylvania.
Westmoreland and Fayette counties could each have more than 36 post offices affected by the proposed cutbacks.
The savings, nationally, from implementing the POST Plan by 2014 would amount to $500 million, Kelley said.
In addition, Saturday office hours at affected post offices would remain intact, as would customer access to post office boxes, he said.
"We look at each office's work hours, in terms of workload, and calculate the time needed to put that mail up so, if there is a problem, we will address it, but we do not anticipate one," Kelley said.
Leaders back office as is
State Rep. Michael Reese, R-59th — Mt. Pleasant Township — along with two areatourism marketing professionals, have also expressed to the Postal Service their support for keeping the Donegal Borough Post Office open as is.
Reese wrote to Linda Cafaro, the POST Plan coordinator at the U.S. Postal Service — Pittsburgh, to stress the office's proximity to the turnpike and its potential for attracting out-of-town customers.
"The Donegal area is a highly traveled corridor for tourism-based businesses including ski and golf resorts, historic landmarks and state parks," Reese wrote. "I am hoping the USPS will reconsider this action and allow the Donegal post office to continue to operate for the traditional 8 hours per day."
Kris Enberg, executive director of the Mountain Laurel Chamber of Commerce in Donegal Township, wrote Cafaro to explain that any change to the office's current operations would result in three scenarios.
"It would be a hardship to residents, devastating to the business community, and confusing to the millions of visitors who exit the turnpike in Donegal and travel throughout the Laurel Highlands," she wrote.
Kelley said the data used to pinpoint post offices such as the one in Donegal for restructuring was based on those with "the least amount of retail business and lowest earned workload."
Ron Virag, executive director of the Laurel Highlands Visitors Bureau, wrote Cafaro to contend that the importance of maintaining the office as a full-service facility to both current and future growth and economic development throughout the entire Laurel Highlands must outweigh such profitability analyses.
"Without a full-service postal facility in Donegal, our ability to retain and attract business and industry there will be substantially handicapped," Virag wrote.
Mary Pickels, a staff writer for Trib Total Media, contributed to this report.
A.J. Panian is an editor for Trib Total Media. He can be reached at 724-547-5722 or at email@example.com.
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Most-Read Mt. Pleasant
- Donegal merchant revives cancer research fundraiser
- Mt. Pleasant-based group offers Narcan session for first responders
- Mt. Pleasant Borough's $10M Main Street project postponed
- Mt. Pleasant Business District Authority plans 'Small Business Saturday' event
- Life Skills students tour Mt. Pleasant-area Subway restaurant
- 'Christmas in the Mountains' to be held Dec. 4-6 in Mt. Pleasant area
- Mt. Pleasant Township Municipal Authority discusses need for new website
- Forbes: Mt. Pleasant church serving up free Thanksgiving dinner
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- Mt. Pleasant plan has no call for tax increase


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of course you havent seen the end of me. I will be here to critique every one of your pump up posts. You yet to state an actual fact in regards to the company...my appologies for calling you out. Your posts are tiring...as were winter2013's. But it is interesting you mention talking to Colin. Colin hasnt been available for comment all week actually. Oh and the name is Shlinker_. eom.
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|The fatty acid composition of the serum phospholipids of children with sickle cell disease in Nigeria.
MedLine Citation:
|PMID: 12401435 Owner: NLM Status: MEDLINE
|The purpose of this study was to determine the fatty acid composition of the serum phospholipids of children with sickle cell disease (SCD) in Nigeria and to compare the relative fluidity of the acyl chains of the serum phospholipids of controls versus the subjects with SCD. It is widely accepted that the fatty acid composition of an individual's serum phospholipids reflects that of their tissue phospholipids. An alteration in the fatty acid composition of membrane phospholipids could affect critical membrane-dependent enzymes and processes (e.g., ion and solute transport, hormone-receptor interactions, signal transduction pathways). We found a significant reduction in the content of polyunsaturated n-3 fatty acids in the phospholipids of subjects with SCD which could result in a reduction of the fluidity of their tissue membranes. Specifically, there was a 40-50% reduction in the proportion of total n-3 fatty acids in subjects with SCD. On the basis of calculated melting points and double bond indices of the acyl chains of the serum phospholipids, the phospholipids of the children with SCD are less fluid relative to those of their healthy counterparts. In addition, we determined that linoleic acid, arachidonic acid, and stearic acid were the major determinants of the fluidity of the acyl chains of the serum phospholipids of the healthy controls and children with SCD.
|R H Glew; J K Casados; Y-S Huang; L-T Chuang; D J VanderJagt
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Publication Detail:
|Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
Journal Detail:
|Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 67 ISSN: 0952-3278 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 2002 Oct
Date Detail:
|Created Date: 2002-10-28 Completed Date: 2003-08-22 Revised Date: 2006-11-15
Medline Journal Info:
|Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: Scotland
Other Details:
|Languages: eng Pagination: 217-22 Citation Subset: IM
|Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
Export Citation:
|APA/MLA Format Download EndNote Download BibTex
|MeSH Terms
Anemia, Sickle Cell / blood*
Case-Control Studies
Child, Preschool
Docosahexaenoic Acids / analysis
Fatty Acids / analysis*
Fatty Acids, Unsaturated / analysis, deficiency
Phospholipids / blood*, chemistry
Sex Factors
Reg. No./Substance:
|0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Phospholipids; 0/eicosapentanoic acid; 25167-62-8/Docosahexaenoic Acids
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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Confession #69 – My Mother-In-Law Thinks I Wet the Bed
Dear Carol
I was so embarrassed about what happened at Christmas that I wanted to leave Barbados as soon as I could. My husband and I live in New York and we spent Christmas with my husband's parents. I get along very well with my father-in-law but not so much with my mother-in-law as she always felt her precious son could have done better than marrying me. She had some bougie girl lined up for him to marry but he was not interested in her, and his mother did not waste any time telling everyone I was not good enough for her son.
But we have been happily married for 5 years and his mother has begun to accept the fact that he loves me and there is nothing she can do about it. Anyhow we had a lovely Christmas and on old year's night my husband took me out to dinner and we had a great time.
We did not get back to the house until around 3am and of course we had been drinking and were feeling horny when we got home. One thing led to another and before long we were having some very passionate sex. Unfortunately for us due to the fact that we had in some drinks we forgot to put a cover on our bed and by the time we had finished making love the mattress was soaked.
And before you ask no, I did not wet the bed; but I am a squirter so usually we put a plastic-back sheet over the mattress before we have sex. When we woke up later on my father-in-law- had a great lunch prepared for us and we gratefully ate our bellies full. But while we were eating my mother-in-law decided to tidy up the bed in our room and found her mattress soaked.
Because she would never think ill of her precious boy she assumed that I wet the bed and proceeded to give me a lecture about how I can get help from my doctor for bladder weakness and how I should consider wearing adult pampers at night if I cannot get to the bathroom.
I was about to tell her she was completely wrong but how could I explain female ejaculation to a 79 year old woman? She would never of believed me and plus there was no way I could have that conversation in front of my father-in-law. So I said nothing and had to spend the next week with her gloating over the fact that she now had something she could pelt in my face to make me shame. And she did so for the rest of the time we were there.
We had to go out and buy a new mattress for the bed and my mother-in-law told everyone in the store she was getting a new mattress because I have a bladder problem and wet the bed. In the end I could not take all the sniggering and finger pointing in the store so I walked out and waited for them in the car.
I told my husband I am never going back to her house to stay but in all honesty I doubt I will be able to keep putting off going back there at some point, especially as I have such a great relationship with my father-in-law.
Thanks for listening
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I'm sorry I know I should not laugh but hahahahahahaaaa, that's too funny.
But seriously JJ, kudos on being a squirter, no wonder your husband chose you over the bougie girl LMAO!
That's sad though….I know what it's like to have someone you do not particularly like having something on you to throw in your face whenever they feel like it. And telling the people in the store you wet the bed was just plain mean.
I think you would be wise to stay away from her house for a while and let's hope she will forget about it in time (but somehow I doubt it). Your other option of course is to explain it to her, and perhaps show her online what female ejaculation really is. But I understand your reluctance in having that kind of conversation with someone of her generation. The only other choice you have is to let her go on thinking you wet the bed.
It's not a good choice but it's just a really unfortunate situation that cannot be easily resolved.
Luv Yall
Carol xoxo


text:
1A Song, a Psalm, by sons of Korah. Great [is] Jehovah, and praised greatly, In the city of our God--His holy hill.
2Beautiful [for] elevation, A joy of all the land, [is] Mount Zion, The sides of the north, the city of a great king.
3God in her high places is known for a tower.
4For, lo, the kings met, they passed by together,
5They have seen--so they have marvelled, They have been troubled, they were hastened away.
6Trembling hath seized them there, Pain, as of a travailing woman.
7By an east wind Thou shiverest ships of Tarshish.
8As we have heard, so we have seen, In the city of Jehovah of hosts, In the city of our God, God doth establish her--to the age. Selah.
9We have thought, O God, of Thy kindness, In the midst of Thy temple,
10As [is] Thy name, O God, so [is] Thy praise, Over the ends of the earth, Righteousness hath filled Thy right hand.
11Rejoice doth Mount Zion, The daughters of Judah are joyful, For the sake of Thy judgments.
12Compass Zion, and go round her, count her towers,
13Set your heart to her bulwark, Consider her high places, So that ye recount to a later generation,
14That this God [is] our God--To the age and for ever, He--he doth lead us over death!
Loading reference in secondary version...


text:
Greg Jackson went 200-216 during his time as Delaware State University's head men's basktball coach.
- Filed Under
Delaware State University, in the midst of a 4-15 season, fired men's basketball coach Greg Jackson on Thursday.
Assistant coach Keith Walker will serve as the interim head coach for the remainder of the 2013-14 season.
During his 14-year DSU coaching career, Jackson went 200-216. His tenure included three ...


text:
Sandy man's condition improved days after I-215 crash
Published December 6, 2012 10:38 am
This is an archived article that was published on sltrib.com in 2012, and information in the article may be outdated. It is provided only for personal research purposes and may not be reprinted.
A 41-year-old Sandy man was upgraded to serious condition on Thursday, three days after he lost control of his speeding car and crashed on an Interstate 215 curve near 6200 South.
"They're expecting him to make it," said Utah Highway Patrol Cpl. Todd Johnson.
Witnesses told troopers that the man was driving between 100 and 140 mph when his southbound Audi A4-2 entered the median and struck a barrier wall about 1 a.m. Tuesday.
The driver, who was not wearing a seat belt, was ejected into the northbound lanes; his car came to a rest on the southbound side of the wall.
UHP continued to investigate the crash, but confirmed that it appeared alcohol was involved.
No other vehicles were involved in the accident.


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Even though the yard is still covered with snow, the anticipation is building. I can hardly wait until it's nice enough outside that I can at least get out and do some cleaning up.
Because the packages have started arriving. . . my jade beans came a few weeks ago, and then my multi-colored carrots, and just this week a box of asparagus roots was delivered—it's so exciting!
I bought the same multi-colored carrot seeds that I put in last year—purple, white, yellow, red, and orange. And an extra packet of the purple ones, just to be sure I've got enough of those.
I have had vastly different experiences with the germination rate of carrot seeds, and it often seems like it's the most unusual ones that have the lowest germination rate. (Yes, you might think that would encourage me to buy the more common orange varieties, but you'd be wrong.) 😉
After my carrot seeds came in the mail, I came across some interesting information that I thought I would share.
Red carrots get their color mainly from lycopene, which is a type of carotene that is thought to guard against heart disease and even some types of cancer. Yellow carrots accumulate xanthopylls, which are pigments similar to beta-carotene (which contributes to good eye health). Purple carrots, on the other hand, have an entirely different class of pigments, called anthocyanins, which are powerful antioxidants.
After finding this information, I felt totally vindicated about my love of colorful vegetables—just think of the health benefits of such a variety!


text:
Lack of time prevented me from posting last week, so here is what happened to the trades discussed on these pages. Overall, my results were mixed, even on the poor side. Nothing tragic, to be sure, but a weak period to start the month of March. Just hope that market patterns and conditions will become more compatible with my way of trading soon.
My trade in the USD-CAD started well enough, with a fill at 1.1032, as intended. The price was falling nicely, coming close to my target of 1.042. It bottomed out at 1.0954 and recovered from there. Very often, I get out trades if prices stop just before my objectives, but this time I failed to recognize what was happening. I should have closed the position at around 1.0980-85, but eventually settled for 1.1006, a stop placed before announcement of Canadian Employment data. Not much to analyze there, numbers were bad and my stop was hit, with the trade yielding only 26 pips.
My other trade, one I had been seeking for about two weeks was a total dud. The GBP-JPY took out my sell order at 169.00 and then immediately turned around. At least here, I had the presence of mind to cut my losses relatively fast, for 73 pips loss. I more or less followed my own rules about closing a trade if a breakout does not have a follow-up right away. The loss was only about 1/3 of my intended target, making it reasonable. At the time, I thought the price would attempt another leg down, hence the new sell order on this chart at 168.72. Obviously, by now the situation has changed and this order is no longer valid.
Markets closed on Friday with increased volatility, so it is possible this activity will carry over the weekend. If this happens, gaps are possible, just like they developed last week. Finally, after prolonged absence, we had price gaps I found tradable. My attention focused on the AUD-JPY, where I simply followed the most recent minor high on the 5m chart, the chart above shows the set up and its objective.
It was a relatively easy trade, which I closed once the target area was reached, for a profit of 23 pips. If we see gaps again in a few hours, I will be looking for trading opportunities, following the above script. In the next post, I will discuss other trades under consideration. Have a great trading week!
Mike K.


text:
67, Female, Single, Adelaide City, SAAdd to favourites
about me
I'm still working on my profile. Want to know more? Nudge me to update my profile by sending a kiss message.
Kiss me free!
At a glance
|joyrene's details
|joyrene's ideal partner
|67 years old
|60 - 74 yrs old
Adelaide City, SA
(Brighton 5048)
|Within 75km of her
|Body type
|A bit overweight, Average
|5'5/165 cm
|5'8/172 cm - 5'10/177 cm
|Smoking habits
|Don't smoke
|Don't smoke
|Relationship status
|Divorced, Widowed
|Have children
Yes, have children who don't live at home
|Yes, have children who don't live at home, Yes, have children living at home sometimes
|Wants children
|Don't want any (more) of my own but yours are fine
|Eye colour
|Hair colour
|Dark Brown
|Ethnic/cultural background
|Political persuasion
|Swinging voter
|Sign of the Zodiac
|Aries Check compatibility »
|Drinking habits
|Occasionally / socially
|Other special diet
|Have pets
|Yes, have pets
|Education level
|Some college
|Sales / Marketing
|Job role
What I'm looking for
Someone who is open honest easy to communicate with and likes to have fun times and quiet times. at home.
- Male, for a relationship or dating
My interests
- Music
- All types except heavy opera and the head banging stuff. Love all the rock n roll Jazz music big band music and a lot of the light opera stuff like Phantom etc.
- Reading
- Like di morrissey bryce courtney books and lots of others.
- Movies & TV
- Anything with george clooney in it. Only joking like a good murder mystery and some of the period pieces which are based on true life.etc.
- Sport
- do not play sport at the moment but go walking either near where i live or on a treadmill at home.
- Other Interests
- enjoy the computer and getting together with friends and my family.
My groups
Contact joyrene
- Send a kiss to flirt and see if there is an initial attraction
- Open up a 30-day contact period* to send unlimited messages
- During the contact period you can also chat if joyrene is online now.
- Get to know joyrene safely and securely before you exchange your personal contact details
* One RSVP stamp is required per contact period.
Kiss me free!
- Last online:
- 28 May '15


text:
This image was taken outside a prominent club in downtown Seattle on Thursday night. As we were leaving this club, along strolled this Basset Hound wearing a cowboy hat, carrying a dead rat. How's that for living in the wild wild west? The dog was walking along without an owner as if he owned the night. He stopped and posed for us to take his photo.
Wild Wild West
By: jenmjusticeSubscribe Channel: Off the Wall Location: Seattle, WA
3 Comments
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says ... on Saturday, Jun 12 at 5:18 PM
LOL a dog taking McGinns pet rat for a walk.
says ... on Monday, Sep 27 at 12:12 AM
dog is a weenie dog, his name is ozzy. him and my dog hang out sometimes. ozzy is a old guy. that loves to ride on his owners moped
says ... on Thursday, Dec 9 at 2:54 AM
Tha's cute and funny at the same time. He sure walks knowing he doesn't need his owner along.Lol, hilarious dog.


text:
Roadside Stories With Bob WilsonEpisode Guide »
Mark is setting up his own road side stand in North Hampton Mass. This artist has a do-over in life and has returned home to live in his parent's basement. He takes us into the woods for a paint splattering with a spoon. Then, in Meredith New Hampshire, we drill a hole, bait a hook and start fishing for a woman? It's a pick-up line you won't forget for a love story on ice. It's a slippery slope for this couple who has been married 20 years.


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Washington High players anticipate the game's final out against Edmond North (Okla.) last Thursday.
- Filed Under
The Washington Wildcats shocked the Tate Aggie Classic field last week with a perfect 4-0 record and championship game victory over defending Oklahoma Class 6A state champion Edmond North.
So, what do the Wildcats do for an encore?
How about playing host to the MaxPreps.com No. 2 team in the country? ...


text:
For more information on MRSA and the eye check out the stories below.Sign up for our free MRSA e mail newsletter
15 thoughts on "MRSA & The Eye"
My husband just was in Duke Medical ctr with MRSA aggressively attacking his left eye. He went thru horrible tap n inject procedures and then emergency eye surgery. Now we wait to see if he regains vision. So your not alone… This is round 2 for us with MRSA↓
lucy c.
my name is lucy & for the past 2 days ive been experiencing irritation & redness in my eye followed by eye bugers all day could these be symptoms of the m.r.s.a??? get bak at me as soon as possible please!!!↓
If you have redness in the eye and, foggy vision, along with rainbow hallows around lights, does it stand for anything beside acute glaucoma and regular glaucoma? As well I want to ask is there any other conditions that can cause these symptoms, I am young.↓
my neice has today been diagonsed with mrsa in her eye, she is 3 weeks old and was born 6 weeks early due to her my sister inlaw having pre-elapsia! have neva heard of mrsa in the eye especially when the baby was in the special care unit!!!↓
Lisa, Please neva get on a medical forumn and use ebonics (ie the word neva). As far as MRSA, it is the killer bug of the century and it is all because we overused antibiotics. MRSA boils on the skin can be treated with Tea Tree Oil (I am not a doctor). I had MRSA really bad at one time and got so sick on antibiotics that I did my own research. Also see if acticoat silver dressings can be applied to the eyes. Silver kills MRSA by just being around it.↓
I was recently splashed in the eye with urine from a person dx to have MRSA in their urine. The nurse on duty at my place of employement flushed my eye with 70 cc of sterile saline within 15 min of the inncident. Is there anthing I should do besides that now that it has been a few days?↓
I had CA-MRSA attack my eye (right)which cause me to lose the vision in that eye. I have had three eye surgeries in 6 months and still have a very damaged eye. I would be interested in hearing what type of surgeries and who did the surgery of anyone that might have had MRSA in their eye.↓
My Mother has been diagnosed with MRSA in her eyes. She is older and suffering from Alzheimer's. I think she got it at the nursing home and she has only been there a little over a month. I have read about the high mortality rate for this disease especially in the elderly. Is an eye infection as dangerous as a staff infection on the skin or other area?↓
mja law
My granson is 6 weeks old & has been diagnosed with MRSA in the eye ,how dangerous is this & can we pass the infection onto my our other grandchidren outside the infected home,& what can we do to prevent spreading the infection↓
m law
my daughter in law & grandson of 4 weeks both have MRSA.what can I do to avoid transfering it to others?how long does MRSA last on body↓
flo Hibbins
I had a triple heart bypass surgery 2 years ago, caught MRSA and it destroyed my Sternum which was also removed. 6 months later a started having spider webs (bleeding) in my eyes and 2 years later they still cannot stop them – I have even had a lens transplant but the bleeding it still there – Do you think the MRSA has tajeb up residence there? And what can I do to stop the bleeding↓
Liz Dixon-Quad Mom
I've had a history of MRSA. 2 1/2 years ago after the birth of my quadruplets I became deathly ill with infection after my colon burst. One of the many infections I suffered through was MRSA. At the time I did not understand what it meant or why I could not see my babies. Since then when I am in the hospital I am always put under contact issolation. Although, the MRSA was not active anymore. I've been told it takes at least three-six solid months of being away from the hospital setting to get rid of it. Unfortunatly, I have had my share of surgeries and illness since. I did not think I'd have active MRSA again, but sure enough, after a simple laproscopic procedure I had a few weeks ago, I ended up back in the hospital with a bad infection. Guess what? It was MRSA. Go figure! I even ended up having it in my eye. So anythings possible, I guess.↓
I work at a nursing facility and there is a resident that has it in his eyes and he pushes himself around in the halls in a wheelchair. Should I be concerned about catching it and should the facility be isolating him?↓
How do I know if my 6 mo. old has mrsa in her eye? It is red(not the actual eye…just the skin around it) and she is always itching it. Today I noticed little tiny bumps around the skin of her eye.↓
I am now 38 years old. One year ago my body was found on the highway. I was sober. 4 resuscatations later, coma, 47 broken bones: hip, pelvis, neck x2, 14 broken facial bones…, triple brain hemorrhages, triple skull crush injuries, re-attachment of my left arm with steel plates, right chest cracked and lung surgically entered for suction and multiple massive strokes, here I am, I live, I walk without aide, my personality and lifetime of memories intact; I fight, I live. The hospital gave me Staff/Mercer in my right eye while I was on life support in my coma. I am now totally, permanately blind in my right eye, now blue, forever. I am told my cornea is just thick scar tissue now. Can my vision be restored?↓


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Chocolate, Dark Rich: This is the rich and creamy Chocolate fragrance that you've been looking for. The fragrance remains strong and satisfying in all manner of toiletries, including cold process soap. It is a dark chocolate with a very pervasive undertone of mocha and cocoa. It does discolor to a gorgeous ebony brown.
Vanilla Content: 15.9%
Liquid Castile Testing Notes: We tested this fragrance in our liquid Castile soap base, we recommend making a small test batch just to be sure you like the results. Thickens when initially mixed. Final soap is a deep, opaque brown.
This fragrance is phthalate free.
Flashpoint: This medium-flashpoint oil (198ºF) cannot ship via USPS regardless of the shipping method you choose at checkout.
Photo Attribution © Can Stock Photo
Read Reviews
Copyright © 1999-2015Bramble Berry® Inc. All rights reserved.


text:
From Time Out Dubai Eating Out 2011Meaning 'pure' in Japanese, the restaurant has a lot to live up to as before you even get to its doors.You have to travel through the opulent surroundings, and security, of the seven-star Burj al Arab and pay a Dhs300 deposit for your table. Luckily, first impressions live up to expectations and you'll be given a guided tour of the eating stations before being seated at your table and everything possible seems to be on offer. Have no fear about coming here as a vegetarian, there is plenty of choice on offer.
As it's buffet style you can gorge in the wide variety of Asian cuisine and sample, discard and retry dishes as many times as you see fit from the Japanese, Chinese, Thai, Indonesian and Korean options on offer. Must eats were the duck in pancakes, lamb roast, Indonesian vegetables and sushi selection of starters. It is also recommended to take the staff up on their offer of mocktails and to keep space for the great selection of desserts and chocolates. But dress smart and make sure to book in advance to get a window table.


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|First session of the "Mavi Marmara" trial in Turkey has concluded
|Written by PCHR
|Sunday, 11 November 2012 00:00
Ref: 93/2012
The first session of the criminal trial on Israel's assault on the humanitarian boat "Mavi Marmara" – resulting in the death of9 Turkish nationals and the injury of many others – was held at the Istanbul Çağlayan Courthouse (7th High Criminal Court) from 6 to 9 November 2012.
The Mavi Marmara was part of the "Gaza Freedom Flotilla," a humanitarian convoy attacked in international waters on 31 May 2010 by Israeli special military forces while sailing towards the Gaza Strip.
The indictment, served by the Istanbul Office of Public Prosecutor, lists 490 individuals, including Mavi Marmara passengers and relatives of the activists from 36 different countries, as "complainant-victims." The accused are: Israeli Chief of General Staff, Rau Gavriel Ashkenazi; Naval Forces Commander, Eliezer Alfred Maron; Air Forces Intelligence Director, Avishay Levi; and Chief of Israeli Military Intelligence, Amos Yadlin.
The accused, represented by lawyers from the Istanbul Bar Association, are being tried as "fugitive suspects" inabsentiafor the following charges under the Turkish Penal Code: voluntary manslaughter; attempted voluntary manslaughter; intentionally causing grievously bodily harm; plundering, abducting or confiscating maritime or railway transportation vehicles; intentionally causing damage to property; deprivation of personal freedom; and inflicting torture and maltreatment.
During the three days of hearings, the court heard testimony from 74 Turkish and foreign eyewitnesses and complainants; the latter were able to submit further evidence, including footage shot during the attack. Upon conclusion of the first session, the court issued its decision to postpone the trial to 21 February 2013.
In addition, the court has decided the following:
1- To check the validity of notices sent to the defendants;
2- To hear in the next session those complainants who have not been heard due to lack of time;
3- To askfor the medical reports concerning Mr.UğurSüleymanSöylemez, a passenger of the Mavi Marmara who hasbeen in a coma for 2.5 years.
The trial wasclosely monitored by numerous human rights observers, media officials and lawyers from different countries.Mr. DavideTundo, a member of the Palestinian Centre for Human Rights' (PCHR)International Unit, attended the trial as an observer.
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text:
WATERWOOD, TEXAS. Waterwood is a resort community located off U.S. Highway 190 on the northwestern shore of Lake Livingston, about twenty-seven miles northeast of Huntsville in northern San Jacinto County. This 8,000-acre development began in 1972. In October 1974 the Waterwood National Country Club, built by Horizon Properties Corporation, opened. The Waterwood Improvement Association, Incorporated, oversees the community. Waterwood has a private security force and a volunteer fire department. The country club offers various recreational amenities including an eighteen-hole golf course, marina, conference center, swimming pools, and a park. In 2000 the population was 100. Many property owners were part-time residents and retirees.
Waterwood Fact Sheet website (http://www.palmerrealestate.com/Main/wwfact.html), accessed May 3, 2005.
The following, adapted from the Chicago Manual of Style, 15th edition, is the preferred citation for this article.Laurie E. Jasinski, "WATERWOOD, TX," Handbook of Texas Online (http://www.tshaonline.org/handbook/online/articles/hlw58), accessed November 29, 2015. Uploaded on June 15, 2010. Published by the Texas State Historical Association.
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text:
Mike Stenger, investment adviser with Goldman Sachs, speaks to the Florence Rotary Club.
One of the leading investment banking firms in the Unites States is bullish on prospects for growth in the stock market this year.
"We believe the U.S. stock market is in for a full market not seen since the 1980s," Mike Stenger, an investment adviser with Goldman Sachs, told Florence Rotarians at their January 27 meeting. He said the stock market has seen periodic upswings over the past couple of years, "but this rally is different."
What makes it different are recovery of the real estate market and rapid progress toward energy independence by the United States. The real estate market made gains in both 2012 and 2013, and he believes 2014 will be even stronger.
"But the bigger bell ringer will be energy independence," said Stenger, a financial adviser with 31 years of experience. "The U.S. is now energy independent for natural gas."
Goldman Sachs is banking on greater use of natural gas for fuel and power because the U.S. is building reserves and the price is about one-fourth that of oil for the same energy output, according to Stenger. Financial analysts with his firm are seeing more truck fleets switching to natural gas. In addition, The Tennessee Valley Authority announced plans last fall to replace two coal-fired power plants in Muhlenberg County with a gas-fired plant.
Goldman Sachs also expects the U.S to achieve energy independence on oil by 2018, "and that will be a game-changer," Stenger said. "Outside our borders, we won't be dependent on any other country.
"We are very excited as we go forward. We've got the reserves (of natural gas) and we've got the refineries" for oil. New technology is making it possible to extract more natural gas from depleted sites through hydraulic fracturing or "fracking" and a gas line that will run from Canada to the Gulf Coast is under construction.
Stenger sees other signs of economic recovery. Goldman Sachs analysts believe unemployment will continue to drop, and more than 200 million jobs will be added this year. He said some manufacturers are starting to "repatriate jobs" - that is, bring jobs overseas back to the United States because labor rates there are doubling and tripling.
However, job gains and economic growth likely will result in rising interest rates and decline in gold prices, according to Stenger.
Stock market shares declined significantly in January, but Stenger contends the drops are typical market fluctuations.
"We believe we will continue to see a little volatility ... but it's normal stuff," he said. "If you compare to the 1980s, the upturn began in 1982 but the average investor didn't get in until 1986. This rally began in 2012."
Submitted by Pat Moynahan


text:
First Media Radio, LLC
Download OptionsReleased: October 23, 2013
Washington, D.C. 20554
October 23, 2013
Released: October 23, 2013
306 Port Street
Easton, Maryland 21601
Re: Forfeiture Order on Reconsideration,
WNVN-LP, Roanoke Rapids, North Carolina,
Fac. ID. No. 43758
NAL/Acct. No. 201341420022
Dear Licensee:
Background.On September 23, 2013, the Video Division released a Forfeiture Order, DA 13-
1942, in the above-captioned matter.1 At the time of the issuance of the Forfeiture Order, the staff
reviewing this matter had not received the Licensee's timely filed response to the Notice of Apparent
Liability in this matter. In accordance with Commission Rule 1.108,2 the Video Division hereby
reconsiders the Forfeiture Order in light of the Licensee's response. However, the Video Division
ultimately concludes, after careful review of the Licensee's response, that the Licensee is liable for a
forfeiture of Six Thousand Dollars ($6,000).
The factual findings and discussion included in the Forfeiture Order are incorporated by
reference herein.3 The Licensee filed a timely response on July 16, 2013.4
Discussion.In its response, the Licensee admits that the violations identified in the Notice of
Apparent Liability occurred.5 These violations constitute repeated violations of the relevant Commission
The Licensee argues, however, that the forfeiture amount is excessive as compared to other cases
in which Licensees filed a greater number of late reports.6 In contrast to the two matters referred to in the
Licensee's response, the Licensee here violated two separate provisions of Section 73.3526, resulting in
two separate $3,000 forfeitures. The Licensee was assessed the standard forfeiture amount under our
Forfeiture Guidelines7 for each violation, and we find no basis to reduce the forfeiture amount.
IT IS ORDERED ON RECONSIDERATIONthat, pursuant to section 503(b) of
the Communications Act of 1934, as amended, and Sections 0.61(f)(1) and 1.80(a)(1)&(2) of the
1 First Media Radio, LLC, Forfeiture Order, DA 13-1942 (Sept. 23, 2013).
3 First Media Radio, LLC, Forfeiture Order.
4 Licensee Response to Notice of Apparent Liability ("Licensee Response") (Jul. 16, 2013) at 1.
5 Id.
6 Id. (citing Kevin O'Kane, Notice of Apparent Liability for Forfeiture, 28 FCC Rcd. 7480 (Vid. Div. 2013) and
Concilio Mision Cristina Fuente de Agua Viva, Inc., 28 FCC Rcd 8878 (Vid. Div. 2013).
7 See Forfeiture Policy Statement and Amendment of Section 1.80(b) of the Rules to Incorporate the Forfeiture
Guidelines, Report and Order, 12 FCC Rcd 17087, 17113-15 (1997), recon. denied, 15 FCC Rcd 303 (1999); 47
C.F.R. 1.80(b)(4).
Commission's rules,8 First Media Radio, LLC SHALL FORFEIT to the United States the sum of six
thousand dollars ($6,000) for repeatedly violating Section 47 U.S.C. 336(f)(2)(A)(ii) and 47 C.F.R.
In the event that the Licensee wishes to revert WNVN-LP to low power television status, the
Licensee need only notify us of this election and request a change in status for the station(s).9 Should the
Licensee elect to revert the stations to low power status, the Licensee would no longer be apparently
liable for the forfeiture amount described herein.
Payment of the forfeiture shall be made in the manner provided for in Section 1.80 (h) of the
Commission's rules within thirty (30) calendar days after the release date of this Forfeiture Order. If the
forfeiture is not paid within the period specified, the case may be referred to the U.S. Department of
Justice for enforcement of the forfeiture pursuant to Section 504(a) of the Communications Act of 1934,
as amended. The Licensee shall send electronic notification of the payment to Peter Saharko at
email@example.com on the date payment is made.
The payment must be made by check or similar instrument, wire transfer, or credit card, and must
include the NAL/Account number and FRN referenced above. Regardless of the form of payment, a
completed FCC Form 159 (Remittance Advice) must be submitted. When completing FCC Form 159,
enter the Account Number in block number 23A (call sign/other ID) and enter the "FORF" in block
number 24A (payment type code). Payment by check or money order must be made payable to the order
of the Federal Communications Commission. Such payments (along with the completed Form 159) must
be mailed to Federal Communications Commission, P.O. Box 979088, St. Louis, MO 63197-9000, or
sent via overnight mail to U.S. Bank Government Lockbox #979088, SL-MO-C2-GL, 1005
Convention Plaza, St. Louis, MO 63101.
Barbara A. Kreisman
Chief, Video Division,
Media Bureau
M. Anne Swanson
Dow Lohnes PLLC
1200 New Hampshire Avenue NW
Suite 800
Washington, D.C. 20036
8 47 U.S.C. 503(b); 47 C.F.R. 0.61(f)(1) & 1.80(a)(1)&(2).
9 See 47 C.F.R. 73.6001(d).
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text:
|Successful resuscitation by emergency room thoracotomy in a patient in agonal state with hemorrhagic shock resulting from penetrating cardiac injury.
MedLine Citation:
|PMID: 12377619 Owner: NLM Status: MEDLINE
|A 23-year-old male patient, who was stabbed in the left chest at the fourth intercostal space leaving a 4-cm wound, was in agonal state with blood pressure of 0/0 kPa when admitted. The patient underwent emergency room thoractomy on stretcher through the left fourth intercostal anterior lateral incision 16 min after injury. The exploration revealed 2 500 ml blood in the plural cavity, 4-cm wound in the pericardium, 2-cm wound in the right ventricle of the heart without asystole, and 5-cm wound in the left upper lobe of the lung. Within 4 min the wound in the heart was sutured with the pericardium as the backing. The patient was discharged with full recovery 8 d after injury.
|Xu Wu; Wu-Jun Wang; Xian-Fu Sang; Zhen-Fu Hu; Gang Chen; Dong-Sheng Chen; Gang Guo; Qian Xiang; Ke Tian; Yue-Hua Peng
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Publication Detail:
|Type: Case Reports; Journal Article
Journal Detail:
|Title: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA Volume: 22 ISSN: 1000-2588 ISO Abbreviation: Di Yi Jun Yi Da Xue Xue Bao Publication Date: 2002 Oct
Date Detail:
|Created Date: 2002-10-14 Completed Date: 2003-01-13 Revised Date: 2006-03-02
Medline Journal Info:
|Nlm Unique ID: 9426110 Medline TA: Di Yi Jun Yi Da Xue Xue Bao Country: China
Other Details:
|Languages: eng Pagination: 918-8 Citation Subset: IM
|Department of Thoracic Surgery, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
Export Citation:
|APA/MLA Format Download EndNote Download BibTex
|MeSH Terms
Cardiopulmonary Resuscitation / methods
Emergency Service, Hospital*
Heart Injuries / surgery*
Shock, Hemorrhagic / surgery*
Treatment Outcome
Wounds, Stab / surgery*
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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text:
I am considering enrolling in an online class this summer. This would be my second time taking an online class. I took a computer based class during one of my previous summer vacations. That class went so well for me. I was pleased to see that one of my classes I planned for the future happened to be offered online. This does not always happen. With the class being online, I could work at my own pace. That would open up my schedule for other things like a job or internship. I have heard many times that online classes are the future, so I figure I should get used to this new type of teaching medium. I do well in online classes because I am organized. I write myself so many notes that there is no way I could forget anything. But not everyone is like me. I have a friend who recently told me that he was enrolled in an online class this semester. But he dropped it and switched to an "in the classroom" section of the course. Why? He forgot to complete the first two chapters' worth of homework. Talk about getting off on the wrong foot. He said that he knew he'd keep forgetting to complete his assignments without his professor reminding him every week in class. So I agree with the decision he made.
As I said, I have heard that online classes are the future. Slowly, colleges and perhaps some high schools and elementary schools will start to switch some classes over to an online format. While this might be more economical, I doubt it will be completely successful, at first. I think if educators can from day one teach students to utilize online
learning efficiently, they can see their students succeed in the online classroom. But I am not sure that some students who are already farther along in their education would be able to adjust to these changes. Students develop their learning habits early on. All of us learn in our own way. But by trying to immerse young students in this type of learning environment, they could develop learning habits specific to this type of learning experience. Adjusting students to different learning environments and tools require proper exposure, repetition and dedication on both the part of the educator and the
So I say, college students, you have to determine if online classes are a good fit for you or if the traditional classroom is a better fit. And as for the future of online classes, the younger generations should be more heavily exposed to this learning tool. Start early.


text:
Best Buy to offer $197 IdeaPad S10, more post-Christmas
updated 12:55 pm EST, Tue December 22, 2009
Best Buy offering post-Christmas computer deals
Electronics retailer Best Buy on Tuesday announced it would offer end-of-season sales on computers. The two-day sale will begin online on Christmas Day, December 25th, with the same deals extending to stores on December 26th. The most significant deal involved the 10.1-inch Lenovo IdeaPad S10 netbook, at $197 versus the regular price of $300. The netbook gets the 1.6GHz Intel Atom N270, 1GB of memory and a 160GB hard drive.
For those needing a larger and more functional notebook, the 17-inch Dell Studio will be priced at $700, representing an $80 savings. Its main specs include a 2.2GHz Intel Core 2 Duo CPU, 4GB of RAM and a 500GB hard drive.
Gamers may be swayed by the 16-inch ASUS G60 notebook, which is $100 cheaper than its regular price, at $900. The particular trim level is powered by a 2.13GHz Core 2 Duo Intel CPU, 4GB of RAM, a 320GB hard drive and NVIDIA's GeForce GTX 260M graphics with 1GB of dedicated RAM.
The sole desktop PC on sale will be the Acer AspireRevo 1600 nettop, priced at $280, or $60 less than regular. It ships with a 20-inch monitor, 1GB of RAM, a 160GB hard drive and its centerpiece NVIDIA Ion LE graphics chipset.
At the same time, from December 27th to January 2nd, Best Buy will offer two HP TouchSmart all-in-one desktops for $100 off, or $799 and $899, respectively. The former sports 4GB of memory and a 500GB hard drive, while the latter adds a larger 640GB hard drive and a TV tuner.
Finally, through mid-January, the retailer will continue to offer its signature "PC Home Makeover" bundle that includes an HP desktop PC, monitor, notebook, netbook, wireless router and Geek Squad network setup for $1,200.


text:
Beach Drive slide lawsuit settled, repairs ahead, says cityAugust 16, 2012 at 4:38 pm | In Safety, West Seattle news | 13 Comments
(WSB 2011 photo of the view from behind the "ecology blocks" at the bottom of the sliding Beach Drive slope)
Earlier this year, when repaving was ahead for a section of Beach Drive close to the ravaged section caught in a dispute over slides, the city revealed more mediation was ahead. Now, there's word it has succeeded. This is just in from the City Attorney's Office:
A significant hillside repair project along Beach Drive in West Seattle will be built without any City funds, in accord with the successful mediation of Anderson v. City, Saladino et. al.
"I am pleased to report that the City has resolved litigation and enforcement actions related to landslides in West Seattle above Beach Drive," City Attorney Pete Holmes said Thursday. "Insurance monies and private funds will be used to construct deep retaining walls and a drainage system to stabilize a hillside. No City funds will be used to construct the project. The City has agreed to waive the majority of fines it sought in this action in exchange for the agreement by Peter Saladino to build the walls."
Saladino and the City were both defendants in this action brought by 29 households that alleged they were affected by the landslides that occurred in 2007 and 2010.
The parties reached agreement late Wednesday night, the second day of mediation.
Saladino personally and the insurance carrier for Saladino agreed to fund and construct the remediation project to stabilize the hillside across a three-property area. The remediation project, which is likely to cost more than $2 million, involves two walls and a drainage system. The project is being reviewed by the Department of Planning and Development and the Department of Transportation and other City departments, with construction likely to begin this year.
The City did not pay attorney's fees. The City did agree, however, to reduce the fines against Saladino to $10,000 if he is able to obtain that amount or more from a neighboring property owner's insurance company. If he is unable to get that amount, the City will waive all fines as to Saladino. In addition, the City agreed to resurface a portion of Beach Drive north of the slide area in 2012.
Tom Rasmussen, chairman of the Seattle City Council Transportation Committee, expressed delight with the settlement: "The area near the slide on Beach Drive is in terrible condition and the agreement will allow the hillside to be repaired and Beach Drive to be repaired and repaved."
We'll add backstory shortly. As part of all this, the city had sued Saladino in 2009; area homeowners sued in 2011.
13 Comments
I'd be very curious to find out from the local families whether they're confident that Saladino and the Insurance company will actually follow-through on constructing the retaining wall/drainage.
Comment by John — 5:51 pm August 16, 2012 #
Yay! That is very Good! I thought they were going to drag their feet so long an earthquake would take care of it for them.
Comment by Noelle — 5:52 pm August 16, 2012 #
I am going to assume that mediation prevailed over an expensive court case. So unless Saladino wants to spend more money they would be smart to comply.
Comment by Kgdlg — 9:21 pm August 16, 2012 #
After reading up on the history of the hill and its multiple slides there is some real responsibility that should have been dealt to the city long ago. I suspect those plots should never have been opened up to the public and the first slide back in the 1930′s happened after road construction around the same time. The city was warned about it by engineers and chose to ignore the problem over the years. I'm glad the wall and drainage is going up but I don't think its a permanent fix.
Comment by cj — 10:01 pm August 16, 2012 #
wall and drains
yea right
they will slap abike lane on it and call it good lol
Comment by marcus ativalu — 10:45 pm August 16, 2012 #
haha – Marcus! Wish there was a 'like' button!
Comment by pam — 7:12 am August 17, 2012 #
Is he being forced to plant trees to replace the ones he cut down?
Comment by Joe — 9:43 am August 17, 2012 #
money talks, perps walk.
Comment by oh man — 11:53 am August 17, 2012 #
I'm certainly glad to hear that taxpayers won't be paying for this mess, but how come no one's saying what caused the problem. When homeowners cut down all the trees on a hillside so they can have their pretty view, the ground becomes over-saturated with rain because there's no more dead leaves left on the ground to shed the excess water off. The result is mass wasting, otherwise known as a landslide. If you look at this person's property, there's not one tree left on the hillside. So as far as I'm concerned, the homeowner is responsible. It should be illegal to cut down trees (even on private property) when it compromises land stability and can threaten other property–public or private..
Comment by Ray West — 7:29 pm August 17, 2012 #
Real funny Marcus. Of course by now I should expect West Seattleites, and Seattleites in general to consider bicyclist safety a laughing matter.
Comment by JN — 10:12 pm August 17, 2012 #
So, help me understand the fines issue. The city has agreed to reduce the fines for Saladino to just 10,000.00 if he can obtain that amount from his neighbors insurance company and if he is unable to, the fines will be waived completely? Sweet!
Comment by 56bricks — 5:39 am August 18, 2012 #
I imagine the goal is to get it fixed. Fines are only useful if they bring people to the table and point of fixing a problem. If it gets done than that is what matters, especially if city isn't footing bill.
Comment by Kgdlg — 3:39 pm August 18, 2012 #
In response to the comment by Ray West, it is illegal to cut trees on a sensitive hillside without a permit, even if you own the trees. This guy is definitely responsible for this slide and he should cover 100% of the price to fix and replant the damaged slope.
Comment by eaglewatch — 9:25 pm August 18, 2012 #
Sorry, comment time is over.
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Bid History for Isaberg Rapid 106 Saddle Stapler
Auction Start Date: 07/12/10 10:02 AM ET
Auction End Date: 07/19/10 7:30 PM ET
Asset ID: 50 Number of Bids: 8
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Isaberg Rapid 106 Saddle Stapler
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Rapid A106 saddle stapler enabling flat stapling.
Includes: foot pedal, vice for adjustable fixing to table top, full box of 1/4" & 5/16" flat wire staples, Owner's Manual, spare parts list.
Most items offered for sale are used and may contain defects not immediately detectable. Bidders may inspect the property prior to bidding. Bidders may view auction items by appointment only, Monday through Friday from 8:00 am to 12:00 pm and from 1:00 pm to 5:00 pm at the warehouse located at 2470 Clower Lane, Bartow, Florida, (863) 534-5610, unless otherwise stated on auction website. No children and only two (2) adult customers at one time are allowed in warehouse.
If you are the winning bidder, contact the Seller PRIOR to arriving to verify where payment is to be made and for instructions on pickup and removal.
|Seller Information
|Special Instructions
|Payment in full is due not later than 5 business days from the time and date of the Buyer's Certificate. Acceptable forms of payment are:
· U. S. Currency up to $500.00
Anything over $500.00 will need to be:
· Certified Cashiers Check
· Money Order
· Company Check (with Bank Letter guaranteeing funds – mandatory)
Checks shall be made payable to: Polk County Board of County Commissioners.
Removal. All items must be removed within 10 business days from the time and date of issuance of the Buyer's Certificate. Purchases will be released only upon receipt of payment as specified. Successful bidders are responsible for loading and removal and any and all property awarded to them. The Buyer will make all arrangements and perform all work necessary, including packing, loading and transportation of the property. Under no circumstances will the Polk County Board of County Commissioners assume responsibility for packing, loading or shipping.
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text:
Linus Ullmark has left the Modo J20 to play for Team Sweden this weekend in a U20 four nations tournament in Kravare, Czech Republic. Team Sweden will play games against Russia (Friday), the Czech Republic (Saturday), and Finland (Sunday) in the three-day event. The same four nations will again convene in early November for another round of games.
Ullmark is coming off a 1-1 mark including a shutout in Modo's preseason visit to Gimo. He'll be sharing the nets with Joel Lassinantti, who earlier in the month joined Ullmark as the odd men out as Sweden put together their final roster for USA's National Junior Development Camp in Lake Placid, NY.
Other notables on Sweden's roster include fellow 2012 draft picks Sebastian Collberg (MON), Ludvig Bystrom (DAL), and Erik Karlsson (CAR), as well as 2013 draft prospects Elias Lindholm, Gustav Possler, Jacob de la Rose, and Linus Arnesson.
Finland's roster has yet to be confirmed but it is possible that Joel Armia remains in Pori for Assat's Saturday game against Vaxjo.
Ullmark off to 4-Nations
Written By Kris Baker on Thursday, August 30, 2012 | 8/30/2012
Written by Kris Baker
Tags: ullmark


text:
About WEATS
Program Information
Sponsors & Organizers
WEATS 2010 - Program Information
WEATS has been used as a method of connecting the information at the federal level of the National Renewable Energy Laboratory to the selected participants that have the best chance to use the information to begin or further wind energy projects on their facilities. In the past we have had attendees from select foreign countries as well as Native American tribes from across the United States.
The goal is to present, in a short amount of time, the general information that is needed to plan a wind energy project. Then to familiarize the participants with the key steps and potential problems with wind energy developments. To do that the participants will be presented with the fundamentals of wind energy, how turbines work, the constraints of location and access to the power grid and the potential economic impact for the region.


text:
Make it: WMU 27, Toledo 23
WMU vs. Toledo, 5 elements of impact: Prediction
Graham Couch | firstname.lastname@example.com By
Follow on Twitter
on September 18, 2010 at 6:00 AM
Follow on Twitter
on September 18, 2010 at 6:00 AM
Winning at Ohio last week on the heels of a lopsided primetime national television loss — albeit to a very good Arizona team — was an impressive result for Toledo. But to win consistently on the road, a team needs strong quarterback play. The Rockets haven't had it yet. It catches up to them tonight.


text:
©2015 General Mills, Inc. All Rights Reserved. This information will only be used to send an email to your friend(s) and will not be saved. Please read our Privacy Policy
Invite family to the dinner table with the spicy aroma and delicious flavor of sweet muffins.
Take the guesswork out of filling muffin cups by using a spring-handled ice cream scoop! Scoops marked with a No. 20 or 24 get most muffin cups about 3/4 full--the amount you need for the rounded tops you want.
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text:
Just bought a new dildo or vibrator? There are lots of positions you can try and you don't have to be a super-flexible stripper to pull off some of these moves!
Just bought a new dildo or vibrator? Exploring your own body is one of the best ways to discover your sexual self. But you don't have to do it all on your back! There are lots of positions you can try with your new sex toy to stimulate yourself and you don't have to be a super-flexible stripper to pull off some of these moves!
Standing Up
If you've got one of those great dildos with a suction cup at the bottom (which most of them have), you can stick it to the wall and back yourself onto it. Get yourself into a position where it's easy to move yourself back and forth and use your hands and arms to support you. It's harder to do this with a normal dildo or a vibrator since you have to hold it with one arm (unless you've got a partner to hold it for you), but try a few different moves and see what works for you; try cocking one leg up on a table or chair or using the corner of a room to give yourself some better balance.
In the Shower
Almost all dildos and many vibrators come in waterproof form these days, so if you've got one of these, why not abuse it! Take your dildo or vibrator into the shower with you and see if you can perform some of the 'standing up' moves above. Otherwise, sitting or kneeling on the shower floor is also a great option and the harder it is to get onto your toy, the more fun it will be to try and satisfy yourself! Ensure yours is fully waterproof, though, before trying.
On the floor
Sometimes, nothing just beats going at it on the floor. This time you can lie on your back with your legs up, on your side or even on your stomach while you have a go at solo doggy-style. Again, if you've got one of those suction-cup dildos or a cone vibrator, sticking it to the floor and bouncing up and down on it will work wonders.
On a Chair
You've probably had sex on a chair before, but … dildo on a chair? Why not! The chair is your friend and you can either sit on the chair with your feet in the air or pressed up against the wall or you can straddle the chair while you sit on your dildo or vibrator – this can be trickier as you may have to hold it in place, but practise makes perfect! (And also makes for great orgasms).
In your mouth
If you want to practise oral sex, using a dildo can be ideal, especially if you've got a 'realistic' one that is in the shape of a penis. Practise using your lips, tongue and hands and pretend that the dildo is really the 'man' of your dreams who you will do anything to please. If you're a newbie who feels intimidated about giving oral sex, a dildo can also be a great way for you to 'warm up' and discover its pleasures for yourself, rather than just for your partner.
During Sex
Of course, if you're with someone, using a vibrator or dildo during sex can be stimulating for both partners. Women tend to like vibrators poised just over their clitoris or you can use either a vibrator or dildo for anal penetration or for double penetration. If using a vibrator, you can experiment with different settings and decide what you both like (and don't like). Whatever you're doing, just remember to make sure you're both enjoying it! If it becomes too much of a strain just do away with the dildo or vibrator for now and go back to it next time once you've had more time to get to know it on your own.
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Available in multiple sizes, this storm shelter is produced by Lee's Precast/Lee's Storm Shelter and reinforced only with Helix Micro-Rebar. Tested at only 13 lbs/yd3 (8 kgs/m3), this storm shelter passed the FEMA 361 Missile Impact Test using a 2x4 at wind speeds in excess of 250 miles per hour.
The below projects are various precast applications that have Helix reinforcement. The application possiblilities are not limited to those represented here.
DTE Energy (provider of energy and energy technology for southeast Michigan) upgraded their service walkways along conveyors with precast suspended slabs reinforced with Helix replacing rebar reinforced panels.
Lightweight precast concrete arch systems for stormwater detention and infiltration. Only 2 inches (50 mm) thick, the arches are designed with with stand three times a semi trucks axel load. Reinforcement is Helix only. No mesh or rebar reinforcement.
Surpassed ASTM Vacuum Test by 3 times. (Tests conducted at Milan Vault.)
Precast burial vaults case using self consolidating concrete.
Dry-Cast concrete pipes; passes ASTM load test.
Decorative sound berrier walls. Designed to withstand 150 mph winds.


text:
WA Labor Leader Mark McGowan has admitted the election campaign which ended in a crushing loss for his party took a physical toll on him - but he is ready to fight on against Premier Colin Barnett.
Mr McGowan is poised to be re-elected on Tuesday as leader of the defeated WA Labor Party, who will return to the parliament next week with just 21 seats opposite a bulked-up Liberal/National coalition.
Three weeks after the devastating result, 45-year-old Mr McGowan said the campaign before the March 9 poll had been gruelling.
"I worked as hard as I could and at the end of it I have to say I was pretty tired, which is why I took a little bit of time off," Mr McGowan said.
"It was hard, it was demanding, but it was a good experience, and there has been a lot of positive feeling on what we tried to achieve."
Since the defeat, Prime Minister Julia Gillard has visited the state without meeting with Mr McGowan. But he blames the Liberal advertising dollar and dirty tricks for the election outcome, rather than dissatisfaction with the Labor brand.
"In the last couple of weeks we did suffer from a couple of things - one was the premier going out and saying he was not sick, which somehow implied that I said he was," Mr McGowan told ABC radio.
"And the Liberal Party had an enormous amount they spent on advertising, and what can't be forgotten is they spent $2 million of taxpayers' money on advertising in the lead-up to the election campaign with their... ads.
"But we need to know that the second term of a government is always more difficult than the first, and there is a lot of material there for us to point out their flaws and deficiencies."
WA Labor chief ready to fight on
WA Labor Leader Mark McGowan has admitted the election campaign which ended in a crushing loss for his party took a physical toll on him - but he is ready to fight on against Premier Colin Barnett.
5 comments
Western Australia seem like a little country of its own.They are protecting thier wealth and like they want to go thier way. Mega rich miners want to hold the power.
Never seem to belong to Australia. maybe we should call WA Saperatist liberal party.
- Commenter
- Quebecois
- Date and time
- April 02, 2013, 11:25AM
yeah, protecting wealth by having GST revenue ripped out of the state. Separatists...we can only dream
- Commenter
- Col
- Location
- Perth
- Date and time
- April 02, 2013, 1:20PM
If Mr McGowan blames "Liberal dirty tricks and adevertising dollars" for the loss, then I suggest WA Labor will not address the real reasons why it lost, and will remain in opposition. The ALP campaign was good, but it is hard to knock off a fairly popular first-term government, in an economy that is awesome. Add to that a federal government that is about to be hammered by this state (yes, federal issues matter in state elections -- mainly because the PM and Wayne Swan would have been tormenting in their joy had the ALP won here). People had made up their minds well before the poll.
- Commenter
- Graham
- Location
- Mandurah
- Date and time
- April 02, 2013, 12:50PM
Let's see, Colin Barnett was the only one who could stand up to Canberra to get more GST revenue. The first Barnett failure as both Gillard and Abbott have told him it wont happen. Colin Barnett was going to build a better public transport system than Labor. Federal Government wont cough up the money? Another Barnett failure. How many times do people have to see a pattern before they change their vote?
- Commenter
- johnny
- Location
- Perth
- Date and time
- April 02, 2013, 12:52PM
"crushing loss"?? Pundits said a loss of 12 seats was expected. WA Labor lost 5 and are down to 21 - more than Geoff Gallop just before he won in 2001. Hardly 'crushing' - and, given the factors working against a win as detailed in this article - not too bad really.
- Commenter
- Jeff
- Date and time
- April 02, 2013, 1:58PM


text:
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Spa Universaire has two locations.
Our primary location is located at the landmark Belvedere Tower in the Golden Triangle Museum District. Our satellite location is centrally located at the Hyatt Regency Denver Convention Center across from the Denver Convention Center.
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text:
A team of researchers at the National
Institutes of Health (NIH) has uncovered the role of two key genes
implicated in the development of inherited forms of breast cancer. In
the May issue of Nature Genetics, Xiaoling Xu, Chu-xia Deng, and
colleagues from the National Institute of Diabetes and Digestive and
Kidney Diseases (NIDDK) unveil a model of tumor formation that holds
great potential for studying breast cancer in women.
The animal model reveals new detail about how mutations in BRCA1 and
another gene, called p53, work in tandem to accelerate tumor formation
and growth. "This model may speed the process of future research on
breast cancer and its treatment," says Xu, lead author of the study.
Researchers at the National Human Genome Research Institute and the
National Cancer Institute also contributed to the project.
Scientists have known that mutations of BRCA1 are involved in the
development of these cancers but had not been able to identify
specifically how alterations in BRCA1 affected the timing and process of
tumor development. "We knew from previous work that the role of BRCA1 in
tumor formation was not straightforward," says Deng, a co-author of the
Recent work by the same team established that BRCA1 plays a critical
role in controlling when cells divide and how genetic material is
duplicated. In the Nature Genetics study, the researchers showed
that mutations in BRCA1 create an environment in which genes such as p53
mutate more readily. "Loss of BRCA1 creates the condition for p53 to
mutate," says Lothar Hennighausen, a mammary gland expert and NIDDK
co-author of the study. "P53 is believed to be the gatekeeper. Then when
you lose p53, the tumor grows," he adds. Half of human tumors have
mutated p53 genes.
Studying the relationship of mutations in BRCA1 and p53 was a complex
process that took over three years. First, to uncover the function of
BRCA1, the researchers bred mice to contain mutations in BRCA1 genes in
mammary gland tissues only, and only at specific points in development.
BRCA1 genes in these mice were unaltered in other cell tissues.
To accomplish this specific "knock-out" of genes, NIDDK's Kay-Uwe
Wagner, the second author of the study, applied a technique that uses
specially developed genes to act like molecular scissors that can
recognize, target, and cut out critical segments of genetic material.
The study of the resulting knockout mice allowed the NIDDK researchers
to build an accurate model of the mechanism by which BRCA1 mutations
lead to tumorigenesis.
When BRCA1 alone was deleted from mammary glands, 5 of 23 of the
experimental mice developed tumors over one year. The tumors showed
rearrangements of chromosomes where p53 is located. To focus on the role
of p53, the researchers then introduced a copy of a mutated p53 gene
into the mice. When the researchers introduced altered p53, 8 of 11 mice
formed tumors, a 90 percent increase. Tumors also grew faster--in 6
months instead of twelve--when the two mutations were present.
"We now have direct genetic evidence that p53 is involved in
BRCA1-associated tumorigenesis," says Xu, "but it is probably not the
only mutation involved. There may be some others, perhaps some that
activate oncogenes--the cancer genes that promote uncontrolled cell
"Animal models are vital to our understanding of human disease. This
model is the first that shows cancer development similar to the
development of breast cancer in women. It will be an important tool for
future work on tumors and their progression," says NIDDK Scientific
Director Allen Spiegel, M.D. The researchers believe that this model
provides a route for testing drugs to prevent tumor formation in humans,
as well as to test the role of environmental agents, such as radiation
or environmental estrogens in tumor growth.
An estimated 175,000 women will be diagnosed with breast cancer in
1999; about 43,000 will die. Mutations in the BRCA1 gene are found in 90
percent of women who have inherited both breast and ovarian cancer, and
in about 50 percent of women with inherited breast cancer alone.
Radio Editors: A one-minute audio report with actualities is
available at 1-800-MED-DIAL (1-800-633-3425).