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Iowa Wesleyan University Named to Victory Media's 2016 Military Friendly® Schools List
Mount Pleasant, Iowa –Iowa Wesleyan University announced today that it has been designated a 2016 Military Friendly® School by Victory Media, the leader in successfully connecting the military and civilian worlds, and publisher of G.I. Jobs®, STEM JobsSM and Military Spouse. Now in its seventh year, the original, premier Military Friendly® Schools designation provides service…Read details


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AmerenUE Supports Wind Power Education In Missouri
|in News Departments > FYI
St. Louis-based AmerenUE and The National Theatre for Children will bring the live theatrical show Boomerang Jack and the Unseen Green Machine to 100 schools across Missouri this fall. Any school in AmerenUE's 57-county Missouri service territory can request the show, which is offered to educators at no charge.
The Boomerang Jack and the Unseen Green Machine show teaches children about conservation and renewable energy.
"We are pleased to again be able to present this fun, exciting production about energy conservation and renewable energy," says AmerenUE president and CEO Tom Voss. "Our kids are one of our most influential audiences."
SOURCE: AmerenUE
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subset: commoncrawl


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"On occasion, you run into some really good potholes and you don't know how deep they are," said Mimi Kohnke of Boise. "It's kind of like diving into the abyss and the unknown when you hit one of those."
Boise Bench
In all, two fire stations would be rebuilt, one would be relocated and another would be remodeled if voters approve the measure. A new $6.8 million fire training facility would also be constructed.
Lindsay Haskins says back in June she noticed a blinking light at her neighbor's house, that's when she realized a camera was pointing right into her bedroom window. Lindsay asked her neighbor to move it, but that hasn't worked.
A Boise antiques mall lives up to its reputation as Idaho's biggest, a veritable attic-on-steroids boasting virtually anything you would need to start--or complete--a collection.
The fire was called in to the home on N. Wilson Court, which is off of Roosevelt. A neighbor told a KBOI 2News reporter that an explosion occurred shortly before the blaze.
Boise Fire officials say the gas main broke at a home at 5120 W. Hill Road.
Ryan Kanady was booked at 11:44 a.m. Friday for the two felonies. A Boise Police spokesman did not have details surrounding the arrest.
A pair of Eagle golfers are on their way to the Big "I" Junior Golf Classic National Tournament in North Carolina this August.
The Albertsons Boise Open has a new tournament date, earlier tee times, and a new entertainment option. Boise native jazz musician Curtis Stigers brings his talents to the tee box.
Officers responded to the call at approximately 7 p.m., and made contact with Marcus Griffin, who had been involved in a dispute with a woman in the motel.
The outdoor municipal pools are operated by the Boise Parks & Recreation Department. All pools are staffed by certified lifeguards.
Family, friends and fellow troops sent off their loved ones in the 949th Transportation Detachment with a farewell ceremony.
State High School scores and highlights from day two of the tournament ...
All the final scores, and a handful of highlights from the Idaho high school state tournament quarterfinals ...
Local post offices worked with The Idaho Foodbank to collect a goal of 200,000 pounds of food for the needy in the area.


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Coquilles d'Escargots de Bourgogne £7.95
48 reusable snail shells for use with tinned snails.
Also suitable for Cichlids in aquaria. They are about 25mm (1 inch) in diameter.
Product Reviews
Good quality large shells
Posted by Gerard on 24th Jun 2015
These shells are large and strong for re-use. Very good price too!
Also excellent for non-culinary purposes - in your aquarium!
Posted by Cathie on 8th Nov 2012
These shells are the ideal shape and size for the smaller shell-dwelling cichlids from Lake Tanganyika e.g neolamprologus multifasciatus. I have tried various other kinds, and these are definitely the best.
They are reasonably priced and arrive quickly and well-packaged from nice people - what more could you want.
Recommended on www.fishkeeping.co.uk!
Once you have completed your review, drop us an email firstname.lastname@example.com


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Personnal web site of Laurent Jouanneau.
Geek. Developer. On the web since 1994.
Last posts
To read on my blog...
- 20 ans, 09/18/2014
- Release of SlimerJS 0.9.2, 08/18/2014
- Outils d'integration continue, retour d'expérience, 03/06/2014
- Comparatif des outils d'intégration continue, 02/05/2014
- Tada! Here is SlimerJS!, 07/15/2013
About me
A little presentation, my resume...
My projects
- Projects and software (in french).
- My web sites (in french).
Coconut palms, Rangiroa, october 2001.
Web standards
I wrote several articles about web standards, some of them have been published on Openweb.
Articles on web standards (in french)


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- Filed Under
Perth Amboy's Yasel Corporan, the lone wrestler in the field with 2011-12 credentials (4th GMC, 2nd district, 3rd region) is the prohibitive favorite. Five other wrestlers - including Bishop Ahr's John Sheedy, Edison's Alex Naiduk and South Plainfield's Ryan Walsh - will battle for second place. Walsh has wrestled a brutal schedule with all but one of his losses (to Corporan) against non-conference foes. They include an 18-6 major decision to Bergen Catholic's Nick Suriano, who InterMat ranks the best 106-pounder in the nation, and a 5-0 setback to Camden Catholic's Tyler McBride, who the Star Ledger ranks sixth in the state. Corporan's lone loss was a 5-4 decision to South Plainfield's Daniel Hedden at 113 pounds in the Morris Knolls Invitational. J.F. Kennedy's Mehul Patel, who was leading Sheedy 4-1 before getting pinned in the third period last week, has upset potential. There will be a round robin for seeding purposes between Carteret's Mohammed Dhillo, Spotswood's Thomas Saulle and Sayreville's Dylan Haltli. Dhillo split with Saulle and Haltli while Haltli decisioned Saulle.
After placing third in the GMC and second in the district at this weight a year ago, all that may stand in the way of Bobby Jordan (Woodbridge) winning a title is freshman Daniel Hedden (South Plainfield). Hedden's only losses are to Bergen Catholic's Tyler Casamenti (4-3) and St. Peter's Prep's Michael Russo (5-3). Jordan's lone setback is a 6-4 decision to Ryan Freeman of St. Joseph Montvale. Unlike Hedden, who has wrestled exclusively at 113 pounds this season, many of the other top competitors in the field have wrestled against 120 pounders. Old Bridge's Kyle Brown, an incumbent district runnerup, is vastly improved and must be considered a legitimate longshot. Undefeated in the conference, two of his losses are to Bryan Damon (Jefferson) and Jimmy Slendorn (Howell). Brown avenged the loss to Slendorn with a pin last weekend. The rest of the field is incredibly balanced and features four incumbent region qualifiers - Ryan Fahy (Spotswood), Alli Raja (J.F. Kennedy), Tyler Gallegos (East Brunswick) and Tyler Burgess (South River). A GMC runnerup and district champion at 106 pounds a year ago, Fahy cannot be counted out, although Burgess pinned him last week for Fahy's first loss since the Dec. 27 Bear Invitational. Gallegos has split with Hunter Black (Bishop Ahr), falling 11-9 and winning 6-5.
The most loaded weight class of the tournament features an incumbent state runner-up (J.F. Kennedy's Carl Buttitta at 106 pounds) and a third-place NJSIAA Tournament finisher (Bishop Ahr's Kyle Brady at 113 pounds). Sal Profaci (Monroe) is the defending conference, district and region champion at this weight. Profaci did not wrestle Brady or Buttitta this season (bumped away from one another in dual meets) but he defeated Brady at the Ironhorse Invitational in October. Brady scored a 6-3 decision over Buttitta last week. Those who think Buttitta's jump to 120 from 106 may be too much to overcome should consider he has been wrestling at 126 and 132 pounds until last Thursday. South Plainfield's Ray Jazikoff was a district and GMCT runnerup at 113 pounds a year ago. He owns a 4-3 decision over Seton Hall Prep's Brenden Calas. Freshman Stephen Nadera of Old Bridge is a legitimate longshot.
Corey Stasenko, widely regarded as the second best 126-pounder in the state by virtue of his 8-5 loss to reigning state champion Mike Magaldo (Watchung Hills) in the Morris Knolls Invitational, won conference and district titles at 145 pounds last winter before placing second in the region and sixth in the state. J.F. Kennedy's Collin Farley could prove a formidable foe in the finals, especially following his Jan. 12 pin of highly regarded Anthony Rice (Brearley). Farley is an incumbent district champion, region runnerup and third-place GMCT finisher. Battle-tested Mike Nadera (Old Bridge) has just four losses including three to some of the state's best 120 pounders (Bishop Ahr's Kyle Brady, Monroe's Sal Profaci and J.F. Kennedy's Carl Butitta). His fourth setback was to Howell's Kris Lindemann, another outstanding wrestler. Nadera and Bishop Ahr's Greg McCrystal are both reigning district champions and fourth-place GMCT finishers. McCrystal has lost twice in overtime to East Brunswick's Sean Glasgow and dropped a 4-3 decision to Somerville standout Nick Wahba. East Brunswick's Mike Nicolaro - the Cinderella story of the tournament following his brilliant comeback from Hodgkin's lymphoma - is the only other wrestler in the field to have placed in the GMCT (fifth) or district (second) last winter. All of Nicolaro's losses are at 132 pounds including setbacks to reigning state champion Scott DelVecchio (South Plainfield) and Brady. Monroe's Chris Muce, a reigning district runnerup, has upset potential.
Reigning state champion Scott DelVecchio, who InterMat ranks seventh nationally, can expect to face East Brunswick sophomore sensation Sean Glasgow or Bishop Ahr's Brian McCrystal in the final. Glasgow's only losses are to three-time undefeated state champion Anthony Ashanult of South Plainfield (a 4-0 decision in which he trailed 1-0 in the closing seconds) and to Jackson Memorial's Brian Hamann (5-1), who has placed fourth in the NJSIAA Tournament each of the past two years. McCrystal won district and region titles (he was named Region V's Outstanding Wrestler) at 132 pounds a year ago. Look out for Perth Amboy's Humberto Argueta, who has faced some outstanding competition and could be the best sleeper in the entire tournament. Argueta has lost to the likes of Ashnault, Corey Stasenko (South Plainfield) and Gordon Wolf (Lawrence). The remainder of the field is incredibly balanced with four other incumbent region qualifiers boasting a legitimate shot at third place. They include Metuchen's Robert Marcantonio, South River's Jack Cruz and J.P. Stevens' Peter Byun. An incumbent district runnerup, Byun has not competed since Jan. 12.
Reigning district champion and NJSIAA Tournament qualifier Mike Palomba (South River) will meet three-time undefeated state champion Anthony Ashnault in the final unless Woodbridge's Nick Carbonaro (incumbent district runnerup) can upset Palomba in the semis. Palomba won by technical fall over Bishop Ahr's McCrystal in the Bear Invitational. Carbonaro dropped a 4-2 decision to McCrystal's brother Greg in a regular-season dual. East Brunswick's Travis Lutzko and Edison's William Povolac are the only other returning region qualifiers in this top-heavy weight class. With Edison dropping to the White Division, Povalac has not seen the competition he faced last year, but he remains a semifinal candidate.
Two-time state runnerup and three-time state placewiner Troy Heilmann of South Plainfield should have no idea who he will face in the final because tremendous parity exists within the rest of the field. Heilmann avenged his only loss of the year - to Camden Catholic's T.J. Miller at the Virginia Duals - with a 1-0 decision over Miller last Friday. InterMat ranks Miller sixth and Heilmann 11th nationally. South River's Mike Zyskowski, a reigning district champion, is the only other returning region qualifier. Piscataway's Naeem Nazeer placed fifth in the GMCT in this weight class a year ago but has lost this season to Sayreville's Nick Taillefer. Zyskowski and Colonia's Jake Pero placed fifth and seventh, respectively, at 138 pounds in last year's GMCT.
With East Brunswick's Mike O'Kane (knee injury) sidelined, three wrestlers are title favorites. South Brunswick's Jordan Pagano is undefeated, including 3-1 decisions over South Plainfield's Dylan Painton and J.F. Kennedy's Tom Farley. Painton's other two losses are to Jack Clark (ranked 14th nationally at 145 pounds by InterMat for McDonogh of Maryland) and Camden Catholic's Chad Walsh . Pagano made a huge jump from 126 pounds, where he placed second in the GMCT and won a district title. Painton is a returning 152-pound conference runnerup and district champion. Farley's only other loss is a 7-0 decision to Newark Academy's Pat Gerish, owner of a 20-1 record who the Star Ledger ranks 8th in the state. Farley was fourth in the GMCT and second in the district at 145 pounds a year ago. Colonia's Pete Melendez placed fifth in the GMCT at 152 pounds last season and could reach the semifinals. Old Bridge's David Hopman is among the top sleepers in the entire tournament. Monroe's Harrison Utter, a transfer from Bergen Catholic who became eligible last week under NJSIAA transfer guidelines, is an unknown quantity with potential.
Undefeated Jonathan Schleifer of East Brunswick, an incumbent third-place NJSIAA Tournament finisher, and South Plainfield's Inan Sikel will meet in the final. Schleifer majored Sikel 15-4 in a regular-season dual. Sikel's only other loss was a 5-3 decision to McDonogh's Toby Hague, one of Maryland's top wrestlers. Expect as much parity for the third-place battle in this weight class as there will be at 145 pounds. Edison's William Viaziz boasts an impressive 15-1 record with a 3-1 decision over J.F. Kennedy's Brandon Farrell. Farrell has defeated three others in the field including a 3-1 decision over Bishop Ahr's Jon Black, an incumbent district runnerup who has been wrestling with a sore knee and will not compete in the GMCT. Piscataway's Javiair White has wrestled outstanding competition including East Brunswick's Jonathan Schleifer and Westfield's Colin Barber, two of the state's top 160-pounders.
Yet another weight class in which the prohibitive favorite - J.F. Kennedy's Brandon Simon - should have no idea who his opponent will be in the final because of the parity within the rest of the field. Simon (1st district, 2nd GMCT, 3rd region, Top 12 NJSIAA) is one of just two incumbent region qualifiers in the field (Carteret's Dakota Smith is the other). Glessman placed 4th in the GMCT at 160 pounds a year ago. Ranking this field is a crap shoot. Unlike most of the field, Carterets Dakota Smith has not wrestled other top contenders in this weight class, but he is a quality athlete who must be considered among the top of the pack.
Undefeated Ali Yildiz is the class of the field as an incumbent GMCT and district champion who qualified for states. The rest of the field is completely muddled with the exception of Mike Muce (district runnerup at 170 last year) emerging as the favorite to join Yildiz in the final. Middlesex's Kyle Dotey placed sixth in the GMCT and third in the district at 182 last year, while North Brunswick's Ron Nazaro returns to the weight class as a region qualifier. South River's Doug Ryan, 8th in the GMCT at 182 pounds a year ago, is a phenomenal athlete with quality wins over Perth Amboy's Hashaun Fullwood and Nazaro. Spotswood's Max Pavlis, who dropped a 3-2 decision to Nazaro but decisioned Ryan 4-3, placed eighth in the GMCT at 170 a year ago. Bishop Ahr's Jake Seider is among the weight class's most improved wrestlers. Piscataway's Eti-ini Udott has a 3-2 decision over Edison's Kevin Karvaski which is significant because Karvaski has one-point decisions over Ryan and Dotey.
The weight class features just three incumbent region qualifiers, none of whom is the favorite. That nod goes to Old Bridge's Erik DeJonge, who has gone undefeated since a knee injury prevented him from competing in last year's district tournament. DeJonge placed second in the GMCT last year. South Brunswick's Constantine Rissiotis has just one loss, an overtime setback to Perth Amboy's Josh Batista, who is sidelined with a broken hand. Perth Amboy teammate Hashaun Fullwood, an incumbent district runner-up, has the potential to reach the championship. The fourth semifinal spot is wide open.
Reigning district champion Michael Quintin of East Brunswick, who placed fourth in this weight class at the GMCT a year ago, is the slight favorite in a competitive field. Quintin has twice defeated Perth Amboy's Mike Chaykivsky in overtime, and needed overtime to decision Tory Russell of South Plainfield. Russell, also a reigning district champ, qualified for the state tournament and placed fifth in the GMCT at this weight last season. Chaykivsky is an incumbent region qualifier. Old Bridge's Chris Middleton benefits from training alongside teammate Eric DeJonge, where the two have split time between 195 and 220 pounds this season. Edison's Carlos Botero - if completely healed from a hand injury - could be a factor, although he did drop a 4-3 decision to Sayreville's Anthony Porcaro. South River's C.J. Ryan is on a timetable to return from a second ACL tear in late January or early February. If Ryan comes back in time for the GMCT, he must be considered a title contender.
With reigning district champion and incumbent GMCT runnerup James O'Connell sidelined (knee injury), Monroe's Tom Tehan is the favorite. Tehan has wrestled the toughest schedule of any in the field, losing two narrow decisions to Manalapan's John Appice. With his upset of Tehan earlier this year, Colonia's Jordan Valle may earn the top seed. Tehan, who was a district runnerup and fifth in the GMCT at heavyweight a year ago, has the most seeding criteria in the field. Spotswood's Amiran Odzelashvili won 14 of 16 bouts in an abbreviated junior campaign and is undefeated this season. He has yet to wrestle a GMC Red Division foe. South Plainfield's Tyler Calderone has yet to lose in conference and has wrestled the second toughest schedule in the field.


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Sutton headed to the Island!
According to the NYIslanders website, defensemen Andy Sutton has signed a 3-year deal with the team.
No financial terms have been announced but Sutton was believed to be seeking a 4M$ per year contract (can you say OVERPRICED?) when free agency began… should be interesting to find out how much he got.


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Well Happy New Year to all ...... I am determined that this will be the year that I am going to understand food and become happy with my body with the inclusion of weight loss
i am going to follow slimming world, I am currently reading Josie Gibsons Diet book and find it interesting how the mind and food are linking from reading the book I am a mindless muncher which I can see in my day to day life
I also have a 4 month old puppy which will be my long walking partner much to his dismay as well as some work out DVDs
i have so many things to look forward to this year and want to be confident with my body and wear the clothes I long to wear!
I have set myself monthly challenges and if I reach them I have rewards such as by end of February I am going to Newcastle for a night out! A swell my birthday is in June so if I have lost 2st by then I will buy a lipsy dress for birthday night out! I have I need motivation and goals to look to fingers crossed this year I will get to grips with food and be a happy healthy girl at the end of the year wearing a lovely dress at my graduation
anyone who who has got any advice or tip will be greatly appreciated
claire x
current weight 11st


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NYT names Arthur Gregg Sulzberger an editor in charge of strategy
The New York Times Monday named Arthur Gregg Sulzberger its senior editor for strategy. Sulzberger led the Times' "innovation report." He's in his early 30s and is the son of Times Publisher Arthur Sulzberger Jr. "There's also a good chance he'll be running the place some day," Joe Pompeo wrote in June.
Memo from Times Executive Editor Dean Baquet follows: Read more
- Tools:
- 4 Comments
- Permalink


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Felix Achoch, 21, was declared dead on July 30 after receiving injuries from an altercation at Club Vision on July 22. He died from his injuries eight days later. / Photo provided by IMPD
- Filed Under
Indianapolis police are asking the public for help identifying the suspects in the recently declared homicide of a Kenyan student and soccer player attending Ivy Tech.
Felix Achoch, 21, died July 30 after an altercation at Club Vision on Lafayette Road eight days earlier. According to the Indianapolis Metropolitan Police Department, the altercation first began in the club and later spilled into the parking lot where Achoch was assaulted by multiple people.


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Buffalo Chicken Sloppy Joes
By Mary Lundschen burbonpecanpie
I bought a pkg of ground chicken and when I got home, did not know what to do with it. Got on line and found this recipe by Rachael Ray. It is a fairly old recipe by her. My husband & I really enjoy it. It's a keeper.
1 1/2 - 2 lb
ground chicken or turkey
2 Tbsp
olive oil or vegetable oil
carrots - finely diced
stalks celery - finely diced
onion - finely diced
2 to 3
garlic cloves - minced - fresh or jar
salt & pepper to taste
2 Tbsp
vinegar - any flavor you have
2 Tbsp
brown sugar
1 Tbsp
worcestershire sauce
1/3 c
buffalo wing sauce - mild or hot
1 c
tomato sauce
1 c
chicken broth
burger buns - split & toasted
1 pkg
(5 oz size) blue cheese crumbles
dill pickle slices - optional
Directions Step-By-Step
1Heat Skillet with oil over medium high heat. Brown Chicken, breaking up, for about 5 to 6 minutes. Add in carrots, celery, onion, garlic, salt & pepper. Cook for about 10 minutes more.
2In a bowl combine vinegar, sugar, worcestershire, tomato sauce, broth & hot sauce. Combine sauce mix into chicken mixture and simmer until vegetables are tender and is the desired consistancy.
About this Recipe
Course/Dish: Chicken


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Diane Turner
CLEVELAND - Diane Turner, 38, of Cleveland, was the last victim identified from Imperial Avenue.
Turner had a criminal record and a history of drug abuse. She was supposed to report to an East Cleveland halfway house in May 2009, but never showed up. Police had a warrant for her arrest and she was never reported missing.
"My brother, John Turner, passed away waiting for the court to punish this animal, who killed his only daughter," Dorothy Pollard said, during the sentencing for Anthony Sowell. "May your pacemaker stop and you die tonight."
The coroner said Turner was the second victim found in the upper floor of Sowell's home, in the third-floor bedroom. Her body was next to Telacia Forston, when a Cleveland SWAT team served a warrant at Anthony Sowell's house in October 2009.
Investigators asked a leading anthropologist and a forensic artist to help identify her remains. Kent State anthropologist C. Owen Lovejoy examined the skull and Linda Spurlock from the Cleveland Museum of Natural History developed a sketch of Turner's face.
It took the county coroner's office longer to identify Turner because her family members were slow to come forward. Her identity was confirmed using her daughter's DNA.
During the trial, few people spoke about Turner. The foster mother of Turner's daughter, Denise, said she had custody of the girl since she was only three weeks old because Turner had seizures. In July 2011, Denise was 10 years old, but saw her mother almost everyday. The foster mother, Jasneth Groves, said the last time she saw Turner was in August or September 2009. That's when she started asking if anyone had seen her recently.
Turner worked occasionally at a Jamaican restaurant in Cleveland called Dailey's. She washed dishes when she needed money.
The father of Turner's daughter, James Martin, testified that he lived with Turner for a short time. In 2002, following the death of her baby, Turner developed a drug problem.
Martin did construction work on the house next to Sowell's house in October 2009.
"It smelled terrible. It's kind of hard to describe," Martin said. Martin said he was around when the police found the bodies
"Diane didn't have many friends," Martin said. Martin said he was working on the house next door when the police discovered the bodies on Imperial Avenue. When authorities began to identify the remains, he said he recognized nine of the 11 victims, including Crystal Dozier, Telacia Fortson and Kim Smith.
Turner's last known address was about a mile from Anthony Sowell's Imperial Avenue home.


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I recently had 2 nerve blocks done and they didn't work or at least they didn't work for very long(few days). I then went in to have RF (nerve burn) done. Last Thursday I went in to have it done on left leg to start with. I was told I would be sore for about 5 days after the procedure. Well, that never happened. They prescribed me 10 percocets for the pain. There was never any pain after. I dont know what to think now. Did the doc do it right?...is one thought. My second thought is to have them do it over again before going to the next leg. My x-ray show some bulging at the L4,L5 but they insist on doing the S1 area. I know that the nerves associated with leg pain stems from the S1 area. It's just that everything seems exactly the same before they started all of these procedures. Right now, I just want both nerves to be burned so good I don't feel any pain after healing from the procedure. This has been going on for 3 years now. I'm also a "cash patient", meaning no insurance. I need help and help fast. I know....consult with my doctor. Every doc I have been to wants to do their own thing and I'm searching for the one who does the right thing. I live in the Memphis area.
Your post is interesting for a number of reasons. Usually (at least if you were an "insurance patient"), when there is not a positive reaction to a nerve block, they will not go ahead with rhizotomy. Usually, if there is no response to a nerve block, it is because the nerve they are blocking is not the pain generator...so they move on to another possibility.
Any of the lumbar nerves can cause pain in the lower extremeties. I sent you a link to a dermatome map which will show which nerve refers pain to which area of the leg. With a bulging disc at the L4-5 level, pain is often felt (in most people)running down the front and anterior side of the leg and into the foot and big toe. S1 runs down the back of the leg and into the little toe.
Have you been able to get a recent MRI? It sounds like you may need to treat the source of the pain rather than try to disrupt the nerve signal.
I told them I had some relief which included the first day of the procedure. I was hurting in lower back from the nerve block (not nerve burn). The total relief time was 3 days. The nerve pain radiates from lower center back which is the L4,L5,S1 area.
My MRI from mid 2007 is what they are going by. The clinic where procedure is done, they have live feed with an x-ray machine. I talked with the head nurse today and told her I had no pain what-so-ever associated with the nerve burn. he told me that was great. The thing is, she told me before I ever had the procedure done, I would be sore for about 5 days. She also told me if the pain in left leg does not go away or feel better by my next RF (on the 16th) to ask for her and she would talk to the doctor about it. Nothing else was said about it.


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Rare images of the musicians, poets and cultural events
that helped shape the 1960s.
All photographs on this web site © 1965, 1967, 2010 by Dale Smith.
All rights reserved. Permission to use without expressed written consent of the photographer prohibited.
®2010 Dale Smith Photography | Design: Dale Smith | Website by Highmarkdesigns.com in South Lake Tahoe


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GOP Debate Questions
Liberal moderators of recent GOP debates have gone to great lengths to keep the candidates attacking each other and steer the discussion away from uncomfortable topics like the economy, the budget and the debt ceiling. George Snuffleupagus, Diane Sawyer, John King and Brian Williams have set the bar pretty high, so Wolf Blitzer will have to get very creative at the CNN debate in Jacksonville. Here are some questions Wolf can use to keep the focus off of Obama:
- Do you think any of your opponents were beat up on the playground as a child? If so, why?
- Newt said beet sugar is more important than cane sugar. Why would he say that? Which type of sugar do you think is more important?
- Does Mitt Romney use the same hair gel as Jon Edwards? If so, should that disqualify him?
- Where do you stand on contraception in gay households in states that don't permit gay marriage?
- If we can solve the problem of illegal aliens by relying on them to do self-deportation, can we also cut police department staffing and rely on self-arresting criminals?
- Terri Schiavo died 7 years ago, but I don't think Brian Williams fully explored the issue in the last debate. Do you think her parents had more right to make her medical decisions than her husband?
- When Jeb Bush was Governor of Florida, he frequently held press conferences in both English and Spanish. Should we be conducting this debate in Spanish?
- If elected President, would you have Margaritas in the White House served with or without salt?
- Is it culturally sensitive for FSU to have the Seminole as their mascot?
- Mitt—you hired undocumented workers as gardeners. Should all gardeners in Florida be subjected to self-deportation?
- The University of North Florida doesn't have a football team. Is that fair?
- There is a famous photo of an alligator and an anaconda that got in a fight in the Everglades. Should the photographer who took the photo lose his health insurance for trespassing on federal property?
- Should dependent children of undocumented workers be allowed to vote without showing ID?
- Should Che Guevarra have been self-deported?
- Boxers or briefs?


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Last night I collected a pair of surprisingly heavy boxes from UPS, in each box was a set of my Captain Sturnbrau figures from Toy2R - the original B&W and the special Edition Pieces of Eight APs. I'm incredibly proud of these and still marvel at how close to my original drawings these are! The quality is also second to none!
I've a few set aside for myself, however I will be selling the remaining figures.
L-R, Original Captain and Pieces of Eight edition.
If you'd like one, please message or preferably email. They will be £35 / $55 each + shipping.
These will go fast so it has to be a first-come, first served basis.
(email address is an image to hopefully fox the old SpamBots)


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Packers Heritage Trail organizers have identified the boy at right, who was walking with Green Bay Packers fullback Clarke Hinkle outside old City Stadium in this photo from the Dec. 18, 1939, issue of Life magazine.
Who's the kid walking with Green Bay Packers great Clarke Hinkle in this Life magazine photo from 1939?
Turns out he lived a couple of blocks from old City Stadium, where the Packers played.
Last month, Packers Heritage Trail organizers put out a call for help, seeking information about the boy's identity. ...


text:
Give Now
The state approves the first needle-exchange program, Governor Pence will run for office again and the ins and outs of special city taxing districts.
Camp Atterbury completed barracks and a dining facility as well as a railhead and deployment center.
Democratic state auditor candidate Michael Claytor says ethics have left the statehouse under Gov. Mike Pence.
The state will perform its own internal auditing, forfeiting about $350,000 in federal grant money annually.
The Indiana State Fair kicked off Friday morning with a hot air balloon launch. The fair runs August 1-17.
Gov. Pence is bringing his economic development team to England to encourage aviation companies to set up shop in Indiana.
Some state legislators wanted the state-funded pre-k pilot program to be up and running by August, but the state plans to implement it in 2015.
The bill the legislature approved last week would ban youth under 16 years old from tanning salons altogether.
Gov. Mike Pence says a preschool pilot for 1,000 students could inform summer study committees on pre-K.
In his State of the State address, Gov. Mike Pence advocated for Indiana to write Common Core-independent standards.


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We were very impressed with the work she was doing and the kinds of results she was getting."
By then the UN had grown to understand the need for knowledgeable people on the ground who could travel across various war-torn African countries and gather evidence on who was vioutf8g arms embargos and how they were doing it. In the coming years, Austin served as a consultant and official expert on panels that investigated sanctions violations in Liberia, the Congo, Uganda, Burundi, Sudan, and Sierra Leone with teams of other human rights investigators who'd long followed Bout's operations.
Her ex-boyfriend, Todd Ewing, a foreign economic development specialist and Bay Area native who began dating her in East Africa during the '90s, described Austin as intense and ambitious. While his own blonde hair and six-foot frame made him conspicuous in the region, he said Austin's "big brown eyes" and polite manner enabled her to slyly convince gritty characters to talk.
"Her MO at that time would be to just disappear for months [on fact-finding trips]," Ewing said. "I always liked to describe her as a sort of spy for the good guys."
Observers say that history handed the equally ambitious Victor Bout a perfect storm in 1991 at just 24 an age when many Americans are looking for their first post-collegiate job.
The Soviet empire dissolved that year, ending the Cold War between Russia and the United States. Economic globalization expanded and gave every creative entrepreneur with good connections, criminal or legit, a chance to make a fortune. Aging Cold Warriors in the Beltway during the Bill Clinton era and later in George W. Bush's cabinet maintained a stark binary ideological view of the world and failed to take seriously the growing threat posed by transnational criminals who had exchanged ideology for profit.
After the Berlin wall fell, corrupt Russian oligarchs infamously plundered the country's assets as they were privatized following years of state control. Some robbed Russia's rich oil reserves. Bout sought its military installations and airfields containing rows of cheaply available and unused commercial planes, all essentially abandoned by the central government.
Profiles of Bout put him in Angola and possibly Mozambique working as a translator for Russian peacekeepers when the Soviet Union broke up. US officials say Victor Anatolijevitch Bout was born in Dushanbe, Tajikistan, a deeply impoverished former Soviet state, and speaks several languages.
Bout told the New York Times in a rare 2003 interview that he purchased three Antonov aircraft for next to nothing in 1992 and used them to exploit a gap in the transit market, at first ferrying innocuous cargo like flowers from South Africa to the Middle East.
But the mogul quickly fostered connections to old Eastern bloc manufacturing and storage facilities in places like the Ukraine and Bulgaria, which were filled with AK-47s ubiquitous in the developing world ammunition, tanks, helicopters, and other military equipment.
Over time, investigators say he erected a complex web of cargo and airline companies designed to throw off suspicion. If one firm faced too much attention from aviation authorities, another was created to hold the assets. Otherwise, bribery, fraud, and forged documents were used, according to a report on Bout created by the US Treasury Department.
Also from this author
Newly available documents expose what happened to a man shot 16 times by SFPD officers two years ago
Nancy Pelosi is raising millions of dollars, but keeping very little for her own reelection campaign


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Seems that the 2nd Civil Support Team of the Ohio National Guard is participating in an exercise where the perpetrators of a chemical attack are posited to be "Second Amendment supporters". Media Trackers tells us the story.
Buckeye Firearms Association spokesman Chad Baus told Media Trackers that "it is a scary day indeed when law enforcement are being trained that Second Amendment advocates are the enemy,"
"The revelation of this information is appalling to me, and to all citizens of Ohio who are true conservatives and patriots, who don't have guns for any other reason than that the Second Amendment gives them that right," Portage County TEA Party Executive Director Tom Zawistowski said in a separate Media Trackers interview.
Not a new paradigm, of course. Law-abiding citizens who are political opponents of the Obama-Holder secular-progressive statist left have been considered enemies all along. Aside from the preposterous scenario, this is yet another of the Federal Government/Law Enforcement/Military leadership's conditioning the American people to think of gun owners (and advocates of free speech, limited government, and due process) to be violent and unreasonable criminals, comprising threats that need to be dealt with in the harsh totalitarian measures so often favored by those far-left ideologues who despise our liberties so. Of note is that, when similar training involved positing an environmental advocacy group committing an act of terror or violence, the apologies were profuse, and immediate.
Before I get the same hackneyed arguments that "this is just a training exercise", the same weak reasoning was used to explain away the following:
- The FBI report that white Veterans who believed in God, the Second Amendment, and limited government were a terrorist threat
- The change in language from "Islamic extremists" to "violent extremists" was mere semantics and not for the purpose of labeling political opposition in the same language as America's enemies
- Increased militarization of police, including having them acquire heavy armored vehicles for use on American streets
- When Barack Obama referred to political opposition when he talked of "punishing our enemies"
- The Joint Staff College posited a training scenario with the enemy being Tea Party activists
There have been myriad other instances where elements of the government have acted against law-abiding citizens as if they were criminals and threats to security, while often ignoring those who are sworn enemies of this country.
"You want to have it as realistic as possible, but you don't want to single out an issue as emotional as that," Eliason said.
Of course, the quote above would never be uttered by any official regarding demonizing of gun owners and advocates of our Second Amendment liberties. Everyone knows that gun owners are evil. That is to say, gun owners that didn't vote for you. Which is almost all of them.
It is telling that the spokesman for the Ohio National Guard was unwilling to talk. Law-abiding citizens who choose to exercise their Constitutional liberties and see themselves portrayed as violent terrorists are due an explanation for such an outrage.


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I was floored to see this chart in a WSJ Op/Ed by Harvard Prof Robert Barro. It purports to argue (once again) for the household versus the payroll survey:
"The right-hand portions of the graphs show that household employment has risen by much more than payroll since 2001. From the end of the recession in November 2001 until January 2004, household increased by 2.2 million while payroll fell by 700,000. That is, household did better by 2.9 million jobs. Similarly, since the peak of payroll employment in March 2001, household employment has risen by 700,000, while payroll has fallen by 2.4 million, so that household did better by 3.1 million."
However, a mere glance at the chart shows that job creation was booming throughout the 90s, and ground to a halt starting around 2001:
Note the tall bars are Recoveries since 1949; The shorter bars reflect the present recovery.
One can hardly look at that chart as a ringing endorsement of the job creation during the past 3 years versus the prior 10. I that Barro was trying to help the President with the tired and discredited Household Survey argument.
Geez, with friends like the that, the Prez doesn't need enemies . . .
Regardless, when one considers historical post recession job creation — using either Payroll or the Household survey — its apparent that the economy at present is vastly underperforming prior post War expansions.
Source: The Economic Policy Institute
Household surveys are on left, Payroll surveys are on the right
Go Figure
WSJ, March 9, 2004
Mr. Barro is a professor of economics at Harvard and a fellow of the Hoover Institution.
The Jobs Picture
March 5, 2004
The Economic Policy Institute
Category: Finance
Please use the comments to demonstrate your own ignorance, unfamiliarity with empirical data and lack of respect for scientific knowledge. Be sure to create straw men and argue against things I have neither said nor implied. If you could repeat previously discredited memes or steer the conversation into irrelevant, off topic discussions, it would be appreciated. Lastly, kindly forgo all civility in your discourse . . . you are, after all, anonymous.
2 Responses to "Employment Surveys, 1993-2003"
"I that Barro was trying to help the President with the tired and discredited Household Survey argument."
I was wondering if you can point out for me how the Household Survey has been discredited.
1) Fed Chief Alan Greenspan testified that the Payroll survey was much more accurate and reliable than the Household survey;
"We have concluded that the data on so-called payrolls survey is surely the most accurate of the two and our suspicion is that at the end of the day there will be revisions to the household data," Greenspan said in response to a question from the House of Representatives Budget Committee. The Fed chief said recent official estimates of immigration are likely "grossly overestimated", which in turn overestimates employment growth as measured by the household survey.
2) BLS March 5 release: When the Household survey is "modified to make it more "similar in concept and definition" to the payroll survey," divergement disappears. See the charts here: http://bigpicture.typepad.com/comments/2004/03/bls_on_payroll_.html
The BLS did this by subtracting from the Household Survey:
1) Total agriculture and related employment;
2) Self-employed, unpaid family and private household workers (nonagriculture);
3) Workers absent without pay from their jobs.
BLS then added back in nonagriculture wage and salary multiple job holders.
The use of the broader standard (including farm and unpaid family workers) is what apparently created the divergement, as shown by the Green lines. Using data "similar in concept and definition" to the Payroll Survey "magically" eliminates the phantom missing jobs
See: BLS on Payroll vs. Household Survey


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My mum tends to want me to try everything she hears from people when they give us advice about horses. Sometimes she also doesn't believe a thing I say and completely trusts what they say just because they are an adult.
Anyway someone was telling us about lupins being really good to feed and being cheaper then a lot of other stuff. My mum bought some this afternoon and wants me to try it. I'm not saying this is bad but I really don't know much about it. We have cracked lupins. I have been trying to find information on the internet with limited success.
I am not totally sure how to feed it to them. I was going to slowly add small amounts to their normal feeds. I have been told you don't have to soak cracked lupins only whole lupins because of a toxin or something. How long should they be soaked for exactly? I was going to soak the cracked stuff anyway before feeding it especially for Pepper because I think it would be too difficult for her to eat because it is so hard.
Also how much should they get eventually? I honestly have no idea about this. And what nutritional value does it have exactly? Thanks for any help.


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The Kelch-like (KLHL) gene family encodes a group of proteins that generally possess a BTB/POZ domain, a BACK domain, and five to six Kelch motifs. BTB domains facilitate protein binding and dimerization. The BACK domain has no known function yet is of functional importance since mutations in this domain are associated with disease. Kelch domains form a tertiary structure of β-propellers that have a role in extracellular functions, morphology, and binding to other proteins. Presently, 42 KLHL genes have been classified by the HUGO Gene Nomenclature Committee (HGNC), and they are found across multiple human chromosomes. The KLHL family is conserved throughout evolution. Phylogenetic analysis of KLHL family members suggests that it can be subdivided into three subgroups with KLHL11 as the oldest member and KLHL9 as the youngest. Several KLHL proteins bind to the E3 ligase cullin 3 and are known to be involved in ubiquitination. KLHL genes are responsible for several Mendelian diseases and have been associated with cancer. Further investigation of this family of proteins will likely provide valuable insights into basic biology and human disease.
Keywords:KLHL; Kelch domain; BTB domain; Ubiquitination; Gene family; Evolution; Mendelian disease; Gene nomenclature; Cancer
The KLHL (Kelch-like) gene family encodes proteins that constitute a subgroup at the intersection between the BTB/POZ domain and Kelch domain superfamilies. First identified in the vaccinia virus [1], the BTB motif was named based on a homologous domain of 115 amino acids in Drosophila melanogaster bric à brac 1, tramtrack, and broad-complex proteins (BTB) [2]. BTB domain-containing zinc finger proteins are conserved evolutionarily from Drosophila to humans and mice with more than 49 family members in the latter two [3]. The POZ domain was initially named after the 120 amino acid motifs present at the amino terminus in poxvirus proteins and zinc finger proteins [4]. The BTB/POZ domain facilitates protein binding [5] as reviewed in Perez-Torrado et al. [6]. Functions observed to be associated with other BTB-containing proteins involve a variety of cellular mechanisms such as control of cytoskeletal organization [7], ion channel gating [8], transcription suppression [9], and protein targeting for ubiquitination through cullin E3 ligases [10,11].
The Kelch repeat or domain is also an evolutionarily conserved structure that can be found from Drosophila melanogaster to Homo sapiens[12]. Based on sequence identity, it has been suggested that each four-stranded β-sheet of the Kelch motif forms one blade of a β-propeller structure [12]. The Kelch superfamily of proteins can be subdivided into five groups. These subgroups include (1) N-propeller, C-dimer proteins, (2) N-propeller proteins, (3) propeller proteins, (4) N-dimer, C-propeller proteins, and (5) C-propeller proteins [12]. Kelch-containing proteins have roles in extracellular communication/interaction, cell morphology, gene expression, actin binding, and can be co-opted by virus post-infection [12]. KLHL family members belong to the N-dimer, C-propeller subclass of Kelch repeat proteins.
In addition to BTB/POZ and Kelch domains, the KLHL family members contain a BACK domain, first described as a 130-residue region of conservation observed amongst BTB-Kelch proteins [13]. Although no function has been assigned to the BACK domain, it is likely to be of functional significance because mutations in this region have been shown to cause human disease [14-19].
The BTB superfamily includes KLHL, KBTBD, and KLHDC subfamilies, which encompass structurally related molecules that differ in the types and numbers of their protein domains. In general, KLHL proteins contain one BTB/POZ domain, one BACK domain, and five to six Kelch motifs (BTB, BACK, 5/6 Kelch). KBTBD proteins have one BTB/POZ domain, occasionally a BACK domain, and two to four Kelch motifs (BTB/POZ, (BACK), 2/4 Kelch). Most KLHDC family members contain only three to seven Kelch motifs and usually do not have BTB or BACK domains (3/7 Kelch). Herein, we describe the evolutionary structure of the human KLHL family, discuss examples of KLHL family member biology, and present an overview of KLHL protein relationship to human disease.
Evolutionary structure of the human KLHL family
There are nine KBTBD genes in the human genome, and their encoded proteins typically possess a BTB and BACK domain and two to four Kelch motifs. Ten KLHDC genes have been defined by the HUGO Gene Nomenclature Committee (HGNC) in the human genome. KLHDC proteins generally do not have BTB or BACK domains and have three to seven Kelch motifs. These subfamilies will not be discussed further in this review.
KLHL proteins generally have a BTB/POZ domain, a BACK domain, and five to six Kelch domains. However, the domain composition for this family can appear to vary depending on the protein domain prediction program used to examine their protein sequences. The KLHL family protein structure is shown in Figure 1. It should be noted that KLHL29, KLHL31, KLHL40, and KLHL41 were previously assigned within the KBTBD family and were listed as KBTBD1 (KLHL31), KBTBD5 (KLHL40), KBTBD9 (KLHL29), and KBTBD10 (KLHL41). When these genes were originally named, they appeared to encode less than the five to six Kelch domains in the standard KLHL (BTB, BACK, 5/6 Kelch) structure. Therefore, they were classified as part of the KBTBD family; however, reannotation has shown that these genes do encode 5/6 Kelch domains. Likewise, the reannotation of KLHDC5 (KLHL42) has shown that it encodes the standard KLHL (BTB, BACK, 5/6 Kelch) structure. Consequently, they have since been placed within the KLHL family.
Figure 1. Schematic diagram of KLHL family members drawn to scale with amino acid numbers listed on the right. 'BTB,' 'BACK,' and 'K' indicate the BTB domain, BACK domain, and Kelch domains, respectively. In case of multiple isoforms, only the first one is depicted. Data was collected from [20] using a motif scan with Pfam HMMs (global or local models).
The HGNC presently defines 42 KLHL genes. They are spread over different chromosomes, though several are located on chromosomes 1, 4, and X (Additional file 1). The number of exons is not conserved and ranges from a single coding exon to 15 coding exons. However the number of KLHL genes is conserved between mammalian species (e.g., Homo sapiens and Mus musculus). ClustalO and phylogenetic analyses of KLHL family members suggest that they can be subdivided into multiple subgroups (Figure 2). KLHL11 appears the oldest to diverge, followed by KLHL42 and KLHL16. The most recent divergences appear to have happened for KLHL9 and KLHL13, followed by KLHL25 and KLHL37 (Figure 2).
Additional file 1. Human KLHL member summary as recorded in the National Center for Biotechnology Information (NCBI, http://www.ncbi.nlm.nih.gov webcite), HUGO Gene Nomenclature Committee (HGNC, http://www.genenames.org webcite), and Online Mendelian Inheritance in Man (OMIM, http://www.omim.org webcite) databases.
Format: XLSX Size: 44KB Download file
Examples of KLHL family members
The KEAP1 gene is clearly a member of the KLHL family. While the well-used KEAP1 symbol has been retained as the official gene nomenclature; it has also been assigned the KLHL19 synonym to clearly group it within the KLHL family. The human KEAP1 (Kelch-like ECH-associated protein 1 gene is located on chromosome 19p13, and the mouse ortholog is located on chromosome 9. KEAP1 was originally identified as a nuclear factor erythroid 2-related factor 2 (NRF2) interacting protein. NRF2 is a transcription factor that is essential for the cellular reaction to electrophiles and binds to the antioxidant response element (ARE) present in promoters of genes involved in phase II detoxifying and oxidative stress enzyme response [24]. KEAP1 was shown to negatively control NRF2 transactivation potential [25]. Some of the genes controlled by NRF2 are important for cellular defense against harmful oxidative stresses that could result in carcinogenesis (as reviewed in Motohashi and Yamamoto [26]). NRF2 interacts as a heterodimer with Maf transcription factor protein that binds to the ARE and activates transcription through the Maf recognition element (MARE) (reviewed in Motohashi and Yamamoto [26]).
KEAP1's ability to repress NRF2's downstream target activation was demonstrated in zebrafish by gain-of-function and loss-of-function experiments in which transcriptional control by NRF2 of glutathione S-transferase gene (gstp) induction was tested in the absence and presence of KEAP1. NRF2-induced gstp expression was repressed when KEAP1 was also overexpressed [27]. KEAP1 was found to promote NRF2 degradation by targeting it for ubiquitination through the cullin 3 ligase complex [28,29], thus preventing NRF2 activity under normal cellular conditions [30]. Domain function analysis of KEAP1 revealed that NRF2 degradation requires both BTB and intervening domains [28].
KEAP1 is localized primarily in the cytoplasm of cells, with a minimal amount in the nucleus and endoplasmic reticulum [31]. KEAP1 scaffolding to the actin skeleton is crucial for effective sequestering of NRF2 into the cytoplasm [7]. Electrophiles promote the nuclear accumulation of NRF2 without altering the subcellular localization of KEAP1 [31]. Furthermore, KEAP1 appears to regulate both translational and post-translational responses to oxidative stress [32,33].
The crystal structure of mouse KEAP1 was resolved to reveal a six-bladed propeller tertiary structure encompassing the Kelch domain [34]. The analysis showed which bonds are needed for structural integrity and proper association between KEAP1 and NRF2 [34]. NRF2 has been suggested to be involved in susceptibility of lungs to cigarette smoke through the induction of antioxidant genes [35]. KEAP1's relationship with cancer is described below.
KLHL2 (Mayven)
KLHL2/Mayven is an actin-binding protein that shares 63% identity (77% similarity) with the Drosophila ring canal (Kelch) protein [36]. The human gene is localized on chromosome 4q21.1, and its murine ortholog is on chromosome 8 [36]. KLHL2 RNA can be detected in developing and adult brain, heart, spleen, lung and liver, and adult kidney but most predominantly throughout the brain including the hippocampus, caudate nucleus, corpus callosum, and amygdala [36]. The KLHL2 protein has been shown to be constitutively expressed in developing and mature oligodendrocytes and neurons where it binds directly to F-actin through its Kelch repeats and plays an important role in the organization of the actin cytoskeleton [36,37]. In developing oligodendrocytes, KLHL2 is upregulated during differentiation [38], and it localizes to lamellipodia (but not filipodia) [39]. KLHL2 overexpression in oligodendrocyte progenitors accelerates neurite outgrowth and leads to longer processes. Conversely, downregulation inhibits process extension [37,38]. KLHL2 co-localizes and associates with FYN oncogene related to SRC, FGR, and YES (FYN) tyrosine kinase through its SH3-binding domain at the N-terminus. This interaction increases upon differentiation, suggesting a role in promoting oligodendrocyte process outgrowth and strengthening of the initial axonal-glial contact mediated by FYN signaling. Based on the type of interaction, it has been suggested that KLHL2 acts as a linker between FYN and actin [38]. Upon depolarization of primary hippocampal neurons with KCl, association of KLHL with actin is enhanced, resulting in re-distribution and translocation along the axonal processes [36]. The functional significance of these findings needs further investigation.
Recently, independent interactions with two different proteins have underscored KLHL2 involvement in ubiquitination. KLHL2 binds to nucleus accumbens-associated 1 (NACC1), a transcriptional repressor protein that interacts also with another KLHL family member, ectodermal-neural cortex 1 (ENC1/KLHL37). KLHL2 may form part of the ubiquitin complex through which NACC1 affects degradation of specific gene products and promotes proteasome activity and trafficking [40]. Finally, interactions of KLHL2 have been shown with neuronal pentraxin with chromo domain (NPCD, encoded by the Npcd gene in mouse which is a read-through between Cbx6 and Nptxr) and with cullin 3. In this case, KLHL2 appears to function as a specific adapter for NPCD ubquitination via cullin 3. Notably, overexpression of NPCD in hippocampal neurons leads to apoptosis [41].
KLHL family members and inherited disease
KLHL members associated with inherited forms of human disease include KLHL3, KLHL7, KLHL9, KLHL12, and GAN (KLHL16). Mutations in KLHL3 have been identified in patients with familial hyperkalemic hypertension. Molecular analyses have shown that most mutations increase the activity of the Na+Cl− symporter in the distal convoluted tubule portion of the nephron. The increased activity causes more Na+ and Cl- reabsorption, increasing blood pressure and culminating in hypertension. Although mutations were identified in this familial disease, screening for single nucleotide polymorphisms (SNPs) in KLHL3 did not reveal any significant association with blood pressure measurements in human subjects, indicating that common variants are not responsible for variations in blood pressure [19].
Patients with autosomal dominant retinitis pigmentosa (adRP), a neurodegenerative disease that leads to loss of rod and cone photoreceptors, carry mutations in KLHL7[18]. Early and often rapid alteration of rod function is a characteristic of the classic form of adRP, but the phenotype observed in the KLHL7 patients differs because of its late onset and preserved rod function in older family members [42,43]. Recent work suggests that KLHL7 protein binds to cullin 3 and that a single mutation in the BACK domain leads to reduced efficiency of cullin 3's ubiquitin ligase activity [44]. KLHL7 and KLHL12 have also been identified as autoantigens in Sjögren's syndrome, an autoimmune disease that causes damage to the salivary and lachrymal glands [45]. No significant immunological response to either KLHL7 or KLHL12 was observed in the sera of healthy individuals [45].
A missense mutation in KLHL9 leads to the development of distal myopathy in human patients. Distal myopathy is a degenerative disease that initially causes atrophy of distal limb muscles and subsequently extends to proximal limbs [46]. Mutations in GAN (KLHL16), or gigaxonin, are linked to human giant axonal neuropathy, an autosomal recessive disorder [14]. Giant axonal neuropathy affects the central and peripheral nervous system that becomes populated with large, dysfunctional axons [16]. Compound heterozygous missense mutations in the Kelch-coding region of gigaxonin have recently been reported in Chinese cases [47].
KLHL family members and cancer
Four KLHL family members are associated with cancer: KLHL6, KEAP1 (KLHL19), KLHL20, and ENC1 (KLHL37). Mutations in KLHL6 are recurrent in cases of chronic lymphocytic leukemia (CLL), a type of leukemia that is predominant in adults. Six mutations were identified within KLHL6 in CLL patients, and all disrupt KLHL6 function in germinal center B cell formation [48,49]. Insertion, missense, frameshift, and missense mutations in KEAP1[17,35] have been identified in cancerous cells of the liver, gallbladder, and lung. Mutations that result in KEAP1 loss of function are thought to facilitate cancer cell expansion. Decreased KEAP1 expression releases the block on the transcriptional activity of NRF2, resulting in increased expression of oxidative stress enzymes and proteins that favor cancer cells survival and proliferation [33,50]. KLHL20 is an important KLHL family member related to cancer progression. KLHL20 is induced by HIF-1α protein and forms a KLHL20-cullin 3 complex that degrades the promyelocytic leukemia protein (PML) leading to prostate cancer progression [51]. Mutations in ENC1 (KLHL37), also called NRP/B, are associated with brain tumors. Mutations reported in KLHL37 are primarily located in the Kelch domain but also exist in the BTB and BACK domains [15]. KLHL37 protein is normally expressed in neurons but not in astrocytes; however, brain tumor cells that arise from astrocytes express KLHL37. It is hypothesized that mutated KLHL37 promotes cell growth, prevents apoptosis, and alters the cytoskeleton [15].
There are 42 KLHL family members encoded in the human genome, containing conserved BTB, BACK, and Kelch domains. KLHL proteins are known to be involved in the ubiquitination process, but the specific roles for each family member have not yet been elucidated. KLHL proteins will likely have multiple substrates. KEAP1 (KLHL19), for example, has at least three (NRF2, IKKβ and BCL-2) as reviewed in Tian et al. [52]. Similar protein motifs amongst substrates such as the ETGE region in NRF2 and IKKβ could be one way to explain how a KLHL protein can bind to more than one protein [52]. Another potential source of substrate diversity is possible through the BTB domain. BTB cross-dimerization between different KLHL proteins could theoretically allow for differential substrate binding depending on the spatial and temporal expression of KLHL proteins. Mutations in certain KLHL genes are detrimental and result in either Mendelian disease or human cancers. We anticipate that further studies will reveal that most, if not all, KLHL proteins have fundamental impacts on human biological processes and disease.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
BSD, TC, AGS, EAB, and JSF. drafted the manuscript. BSD, EAB, and JSF carried out sequence alignments and/or domain structure analyses. All authors read and approved the final manuscript.
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Zollman S, Godt D, Prive GG, Couderc JL, Laski FA: The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila.
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Perez-Torrado R, Yamada D, Defossez PA: Born to bind: the BTB protein-protein interaction domain.
Kang MI, Kobayashi A, Wakabayashi N, Kim SG, Yamamoto M: Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes.
Minor DL, Lin YF, Mobley BC, Avelar A, Jan YN, Berger JM: The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel.
Melnick A, Ahmad KF, Arai S, Polinger A, Ball H, Borden KL, Carlile GW, Prive GG, Licht JD: In-depth mutational analysis of the promyelocytic leukemia zinc finger BTB/POZ domain reveals motifs and residues required for biological and transcriptional functions.
Furukawa M, He YJ, Borchers C, Xiong Y: Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.
Xu L, Wei Y, Reboul J, Vaglio P, Shin TH, Vidal M, Elledge SJ, Harper JW: BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.
Adams J, Kelso R, Cooley L: The kelch repeat superfamily of proteins: propellers of cell function.
Stogios PJ, Prive GG: The BACK domain in BTB-kelch proteins.
Bomont P, Cavalier L, Blondeau F, Ben Hamida C, Belal S, Tazir M, Demir E, Topaloglu H, Korinthenberg R, Tüysüz B, Landrieu P, Hentati F, Koenig M: The gene encoding gigaxonin, a new member of the cytoskeletal BTB/kelch repeat family, is mutated in giant axonal neuropathy.
Liang XQ, Avraham HK, Jiang S, Avraham S: Genetic alterations of the NRP/B gene are associated with human brain tumors.
Yang Y, Allen E, Ding J, Wang W: Giant axonal neuropathy.
Shibata T, Kokubu A, Gotoh M, Ojima H, Ohta T, Yamamoto M, Hirohashi S: Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer.
Gastroenterology 2008, 135:1358-1368.
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Friedman JS, Ray JW, Waseem N, Johnson K, Brooks MJ, Hugosson T, Breuer D, Branham KE, Krauth DS, Bowne SJ, Sullivan LS, Ponjavic V, Gränse L, Khanna R, Trager EH, Gieser LM, Hughbanks-Wheaton D, Cojocaru RI, Ghiasvand NM, Chakarova CF, Abrahamson M, Göring HH, Webster AR, Birch DG, Abecasis GR, Fann Y, Bhattacharya SS, Daiger SP, Heckenlively JR, Andréasson S: Mutations in a BTB-Kelch protein, KLHL7, cause autosomal-dominant retinitis pigmentosa.
Louis-Dit-Picard H, Barc J, Trujillano D, Miserey-Lenkei S, Bouatia-Naji N, Pylypenko O, Beaurain G, Bonnefond A, Sand O, Simian C, Vidal-Petiot E, Soukaseum C, Mandet C, Broux F, Chabre O, Delahousse M, Esnault V, Fiquet B, Houillier P, Bagnis CI, Koenig J, Konrad M, Landais P, Mourani C, Niaudet P, Probst V, Thauvin C, Unwin RJ, Soroka SD, Ehret G: KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron.
Nat Genet 2012, 44:456-460.
MyHits [http://myhits.isb-sib.ch webcite]
National Center for Biotechnology Information (NCBI) [http://www.ncbi.nlm.nih.gov/protein webcite]
European Bioinformatics Institute (EBI) [http://www.ebi.ac.uk/Tools/msa/clustalo webcite]
Bioinformatics Services [http://www.ebi.ac.uk/Tools/phylogeny/clustalw2_phylogeny webcite]
Itoh K, Chiba T, Takahashi S, Ishii T, Igarashi K, Katoh Y, Oyake T, Hayashi N, Satoh K, Hatayama I, Yamamoto M, Nabeshima Y: An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements.
Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, Yamamoto M: Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain.
Motohashi H, Yamamoto M: Carcinogenesis and transcriptional regulation through Maf recognition elements.
Kobayashi M, Itoh K, Suzuki T, Osanai H, Nishikawa K, Katoh Y, Takagi Y, Yamamoto M: Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system.
Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K, Yamamoto M: Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.
Furukawa M, Xiong Y: BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase.
McMahon M, Itoh K, Yamamoto M, Hayes JD: Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression.
Watai Y, Kobayashi A, Nagase H, Mizukami M, McEvoy J, Singer JD, Itoh K, Yamamoto M: Subcellular localization and cytoplasmic complex status of endogenous Keap1.
Lo SC, Hannink M: PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex.
Mitsuishi Y, Motohashi H, Yamamoto M: The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism.
Padmanabhan B, Tong KI, Ohta T, Nakamura Y, Scharlock M, Ohtsuji M, Kang MI, Kobayashi A, Yokoyama S, Yamamoto M: Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer.
Singh A, Misra V, Thimmulappa RK, Lee H, Ames S, Hoque MO, Herman JG, Baylin SB, Sidransky D, Gabrielson E, Brock MV, Biswal S: Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer.
Soltysik-Espanola M, Rogers RA, Jiang S, Kim TA, Gaedigk R, White RA, Avraham H, Avraham S: Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain.
Williams SK, Spence HJ, Rodgers RR, Ozanne BW, Fitzgerald U, Barnett SC: Role of Mayven, a kelch-related protein in oligodendrocyte process formation.
Jiang S, Avraham HK, Park SY, Kim TA, Bu X, Seng S, Avraham S: Process elongation of oligodendrocytes is promoted by the Kelch-related actin-binding protein Mayven.
Montague P, Kennedy PG, Barnett SC: Subcellular localization of Mayven following expression of wild type and mutant EGFP tagged cDNAs.
Korutla L, Wang P, Jackson TG, Mackler SA: NAC1, a POZ/BTB protein that functions as a corepressor.
Tseng LA, Bixby JL: Interaction of an intracellular pentraxin with a BTB-Kelch protein is associated with ubiquitylation, aggregation and neuronal apoptosis.
Hugosson T, Friedman JS, Ponjavic V, Abrahamson M, Swaroop A, Andréasson S: Phenotype associated with mutation in the recently identified autosomal dominant retinitis pigmentosa KLHL7 gene.
Wen Y, Locke KG, Klein M, Bowne SJ, Sullivan LS, Ray JW, Daiger SP, Birch DG, Hughbanks-Wheaton DK: Phenotypic characterization of 3 families with autosomal dominant retinitis pigmentosa due to mutations in KLHL7.
Kigoshi Y, Tsuruta F, Chiba T: Ubiquitin ligase activity of Cul3-KLHL7 protein is attenuated by autosomal dominant retinitis pigmentosa causative mutation.
Uchida K, Akita Y, Matsuo K, Fujiwara S, Nakagawa A, Kazaoka Y, Hachiya H, Naganawa Y, Oh-Iwa I, Ohura K, Saga S, Kawai T, Matsumoto Y, Shimozato K, Kozaki K: Identification of specific autoantigens in Sjogren's syndrome by SEREX.
Cirak S, von Deimling F, Sachdev S, Errington WJ, Herrmann R, Bönnemann C, Brockmann K, Hinderlich S, Lindner TH, Steinbrecher A, Hoffmann K, Privé GG, Hannink M, Nürnberg P, Voit T: Kelch-like homologue 9 mutation is associated with an early onset autosomal dominant distal myopathy.
Xu M, Da YW, Liu L, Wang F, Jia JP: Giant axonal neuropathy caused by a novel compound heterozygous mutation in the gigaxonin gene.
J Child Neurol 2012. Publisher Full Text
Kroll J, Shi X, Caprioli A, Liu HH, Waskow C, Lin KM, Miyazaki T, Rodewald HR, Sato TN: The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen receptor signaling and germinal center formation.
Puente XS, Pinyol M, Quesada V, Conde L, Ordóñez GR, Villamor N, Escaramis G, Jares P, Beà S, González-Díaz M, Bassaganyas L, Baumann T, Juan M, López-Guerra M, Colomer D, Tubío JM, López C, Navarro A, Tornador C, Aymerich M, Rozman M, Hernández JM, Puente DA, Freije JM, Velasco G, Gutiérrez-Fernández A, Costa D, Carrió A, Guijarro S, Enjuanes A: Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia.
Ohta T, Iijima K, Miyamoto M, Nakahara I, Tanaka H, Ohtsuji M, Suzuki T, Kobayashi A, Yokota J, Sakiyama T, Shibata T, Yamamoto M, Hirohashi S: Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.
Yuan WC, Lee YR, Huang SF, Lin YM, Chen TY, Chung HC, Tsai CH, Chen HY, Chiang CT, Lai CK, Lu LT, Chen CH, Gu DL, Pu YS, Jou YS, Lu KP, Hsiao PW, Shih HM, Chen RH: A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression.
Tian H, Zhang B, Di J, Jiang G, Chen F, Li H, Li L, Pei D, Zheng J: Keap1: one stone kills three birds Nrf2, IKKbeta and Bcl-2/Bcl-xL.


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|Protease inhibitor monotherapy as maintenance regimen in patients with HIV infection.
MedLine Citation:
|PMID: 23016538 Owner: NLM Status: MEDLINE
|Despite the remarkable success of combination antiretroviral therapy, usually including the association of three antiretroviral drugs selected from two different classes, the possibility of treating HIV-infected patients with one single potent agent as simplified maintenance regimen has attracted clinicians and researchers over the past years. Monotherapy with one ritonavir-boosted protease inhibitor in subjects with persistently suppressed plasma HIV RNA offers several potential advantages, such as avoiding the long-term toxicity associated with nucleoside/nucleotide analog, reducing costs, preventing drug-drug interactions, and preserving future treatment options. Several controlled and uncontrolled studies have assessed efficacy and safety of this monotherapy strategy, and the majority of available data concern lopinavir/ritonavir and darunavir/ritonavir. The virological efficacy of these boosted protease inhibitors as monotherapy is slightly lower than that of standard therapy, but the risk of resistance development is minimal and the re-introduction of nucleoside analogues usually leads to a re-suppression of the plasma viral load. Even though currently there is no consensus about the clinical use of protease inhibitor monotherapy for the treatment of HIV infection, this strategy seems an option for selected patients on stable combination therapy, with persistently suppressed plasma viral load, and without a history of virologic failure while receiving protease inhibitors. The aim of this article is to review and summarize the most recent randomized and observational studies which have evaluated efficacy and safety of the protease inhibitor monotherapy.
|Leonardo Calza; Roberto Manfredi
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Publication Detail:
|Type: Journal Article; Review
Journal Detail:
|Title: Current HIV research Volume: 10 ISSN: 1873-4251 ISO Abbreviation: Curr. HIV Res. Publication Date: 2012 Dec
Date Detail:
|Created Date: 2013-01-01 Completed Date: 2013-05-15 Revised Date: 2013-06-03
Medline Journal Info:
|Nlm Unique ID: 101156990 Medline TA: Curr HIV Res Country: Netherlands
Other Details:
|Languages: eng Pagination: 661-72 Citation Subset: IM
|Department of Internal Medicine, Geriatrics and Nephrologic Diseases, Section of Infectious Diseases, S. Orsola-Malpighi, "Alma Mater Studiorum" University of Bologna, Italy. email@example.com
Export Citation:
|APA/MLA Format Download EndNote Download BibTex
|MeSH Terms
HIV Infections
drug therapy*,
HIV Protease Inhibitors / therapeutic use*
Lopinavir / therapeutic use
Maintenance Chemotherapy / methods*
RNA, Viral / drug effects
Randomized Controlled Trials as Topic
Ritonavir / therapeutic use
Sulfonamides / therapeutic use
Viral Load
Reg. No./Substance:
|0/HIV Protease Inhibitors; 0/Lopinavir; 0/RNA, Viral; 0/Ritonavir; 0/Sulfonamides; YO603Y8113/darunavir
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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- Filed Under
Free prom shopping at Catholic Social Service
Teens looking for formal attire for prom are invited to shop for free at the Catholic Social Service Shop for Prom event from 9 a.m. to 4 p.m. today. Find gently used dresses, suits, shoes, shirts, ties, handbags and jewelry. CSS is located in Barrigada, behind the Department of Revenue & Taxation. Donations from the community of any these items will be accepted. For more information, call Clair at 635-1441/2.Training for parents of kids with disabilities
Training for parents who have children with disabilities is offered from 6 to 8 ...


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Vehicles as housing: 27-sq-ft bike home + rowboat shelter
- Uploaded by Extraett on Feb 13, 2012
- Views: 342
"I don't know if I could have a car without a bed in it." San Francisco Jay Nelson has put beds into nearly every vehicle he's ever owned, including a semi-totalled Honda Civic (bought for $200) and a tiny rowboat (found on craigslist).
He's even made a moped into a camper, but his most impressive podmobile is the electric camper bike he built from scratch using parts "you can find at a hardware store".
He bought the PVC pipe chassis online, along with an electric motor (he discarded his initial pedal-powered design because of the San Francisco hills) and began to build the vehicle in his driveway.
He calls his tiny mobile home the Golden Gate and with an electric motor range of 10 miles, it can go basically anywhere within San Francisco (7 x 7 square miles) at a top speed of 20mph.
Original story: http://faircompanies.com/videos/view/electric-kool-aid-acid-pod-is-craft...
Photo credit: Jack Halloway http://www.flickr.com/photos/jackhalloway/
Music credit: Dave Warstler http://www.davewarstler.com/
Jay's designs: jaynelsonart.com


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Concern by hello!: what is the best seashore body exercise online video?
i want to acquire a exercise DVD because in 2 months i am planning to florida. i want to lose about ten lbs . and get that hot hourglass seashore entire body i've often dreamed of.
which is the greatest work out video? i require the outcomes to present quicklyy
i have read p90x is extraordinary! but, its far too costly for my price assortment. anything more affordable?
Greatest reply:
Solution by Bestcovery
P90X Property exercise method. If you stick with this system and follow it for two months, you will be definitely astonished!
Know much better? Go away your possess response in the comments!


text:
Rules of Attraction (Mass Market Paperbound)
The Rules of Enticement:
A woman should never surrender to a man without knowing his intentions. A man should never seduce a woman for the purposes of revenge.
Rules of Society
After nine years, Hannah Setterington has decided tosell the Distinguished Academy of Governesses and explore the secrets of her past. To that end she has agreed to be a companion to the elderly aunt of Lord Raeburn, a man enshrouded by dark mystery and haunted by the rumor that he murdered his wife. A strong-minded woman accustomed to the vagaries of nobility, Hannah believes the rumor to be so much piffle, until she comes face to face with Lord Raeburn.
Rules of Fascination
Dougald Pippard, Lord Raeburn, is deviously satisfied when his plan to trap Hannah springs itself successfully. But his satisfaction is short-lived as the indomitable Hannah draws the battle lines and kisses him with the pent-up passion Dougald hasn't felt for nine long years. The fire that has always flared between them rages again with every touch, every glance, until Dougald is almost ready to forget his wounded memories and plans of revenge for just one more night with her.
Rules of Attraction.
About the Author
Christina Dodd is a New York Times bestselling author whose novels have been translated into twelve languages, featured by Doubleday Book Club(r), recorded on books on tape for the blind, given Romance Writers of America s prestigious Golden Heart and RITA Awards, called the year s best by Library Journal, and, at the pinnacle of her illustrious career, used as a clue in the Los Angeles Times crossword puzzle. Christina Dodd lives in Washington with her husband and two dogs.


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- KNIA / KRLS - http://kniakrls.com -
Fixing and Reporting Potholes in Pella
Posted By News On March 1, 2014 @ 5:57 am In Today's Local News | Comments Disabled
When the City of Pella needs a pothole fixed, Public Works Director Denny Buyert says they also have two options depending on the weather. The top choice for workers is a hot mix that can only be used between April 15th and November 15th, and costs $60 a ton. The other option, a cold patch called UPM, is $140 a ton. Byart says that city workers are always on the lookout for holes, but if you see one that needs tended to, you can call Public Works in Pella at 628-1601.
Article printed from KNIA / KRLS: http://kniakrls.com
URL to article: http://kniakrls.com/2014/03/fixing-and-reporting-potholes-in-pella/
Click here to print.
Copyright © 2009 KNIA/KRLS. All rights reserved.


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- Studio: Screen Gems
- Release Date: May 13, 2011
- Starring: Cam Gigandet, Maggie Q, Paul Bettany
"Priest," a western-fused post-apocalyptic thriller, is set in an alternate world -- one ravaged by centuries of war between man and vampires. The story revolves around a legendary Warrior Priest from the last Vampire War who now lives in obscurity among the other downtrodden human"Priest," a western-fused post-apocalyptic thriller, is set in an alternate world -- one ravaged by centuries of war between man and vampires. The story revolves around a legendary Warrior Priest from the last Vampire War who now lives in obscurity among the other downtrodden human inhabitants in walled-in dystopian cities ruled by the Church. When his niece is abducted by a murderous pack of vampires, Priest breaks his sacred vows to venture out on an obsessive quest to find her before they turn her into one of them. He is joined on his crusade by his niece's boyfriend, a trigger-fingered young wasteland sheriff, and a former Warrior Priestess who possesses otherworldly fighting skills.(Sony Screen Gems)
… Expand
- Director: Scott Stewart
- Genre(s): Action, Thriller, Horror
- More Details and Credits »
Autoplay: On | Off
Score distribution:
Positive: 1 out of 13
Mixed: 10 out of 13
Negative: 2 out of 13
To Stewart and screenwriter Cory Goodman's credit, the whole set up takes about 10 minutes flat, leaving Priest's remaining 77 minutes to the dark, desolate action at hand. Even more to their credit, there's something evocative in that darkness, something poetic in its desolation.
In an era where monster mythology has become raw material for all sorts of mediocrity, Priest is one of the best examples of a broad-scale vampire blockbuster.
It appears that turning the John Ford/John Wayne classic "The Searchers" into the church-vs-vampire adventure Priest was not an altogether god-awful idea. As long as we don't get "The Man Who Shot Liberty Valance" as an elegiac zombie drama, this adaptation of a graphic novel has some bite.
Its B-movie sins are many, worst among them an icy hero and a plot that feels like it was built from relics of other, better films.
Bettany exudes an intensity that lays the groundwork for an interesting character, but Priest hasn't a prayer of creating anything more subtle than the giant cross tattooed on his face.
May 13, 2011The film is somehow a disappointing combo of too-full and oddly empty. Even with all the various parts and pieces going into its structure, it feels bare-bones.
Bettany's performance consists entirely of a purposeful frown paired with a menacing glare: He goes about his godly business with solemn, no-frills intensity. The film follows suit.
Score distribution:
Positive: 25 out of 71
Mixed: 23 out of 71
Negative: 23 out of 71
Aug 21, 2011This review contains spoilers. i have to say that this movie actually surprised me. i thought this movie had decent dialogue (could've been much better) the action scenes were fantastic and the plot was decently put together. considering the fact that the producers had very low intentions for this movie anyway makes it even better. i believe if they had any real hope in this movie it could have been very much better. while watching it i though of countless scenarios to which priest 2 could be about(im actually trying to write a script for the second one just for fun) this movie has real potential. they could've tied in religion a little deeper into the action, etc.i also like the way they depicted the vampires. i like that they took the eyes away, considering that "vampires are soul-less creatures". the ending of the movie was a cliff hanger pretty much (they never found the queen). so they can work that into the sequel (which is one of the major stories of my script :-] ). there are many scenarios they can work into it to make the movie much better. so, this movie has real potential but nobody really believed it would do goo, so that's why it really didn't. the key to any movie is confidence.. with out that, you wont put much effort into the production and in the end have a disaster of a movie....… Collapse
May 15, 2011People giving this movie bad reviews either don't like vampire movies, or don't know anything about them. Priest is not meant to be Twilight.People giving this movie bad reviews either don't like vampire movies, or don't know anything about them. Priest is not meant to be Twilight. It's not meant to be sexy. It's meant to be awesome, and it is. Another guy on here was talking about Hollywood taking rated R movies and making them PG13 (which makes them horrible normally-I definitely agree)...I think this movie is the exeption to that PG13 is censored R rule. Priest is not a movie that feels like it was forced into being PG13 and I remember being worried about it sucking because it is pg13. I mean the movies' main character is a priest...it's not like there's going to be a lot of sex and 'bad' words...the violence is bloody, not gory.
I was not at all disappointed. I love this movie so much. I came...
To see a vampire movie and I got one with bits of satire and references to old western movies. The cinematography was awesome- the colors, the angles, the composition- beautiful. The fight scenes ruled. The cgi wasn't overdone. The violence was tasteful. The storyline was interesting and original. The style of the wardrobes and the environment gave subtle reference to the Final Fantasy/steam punk styles and it worked out really well. I don't normally write reviews... I really wish I'd get paid for this (because I'm spending a lot of time writing reviews about this movie)... But this movie was so good that I decided I would write one...and after I saw what critics were saying about this movie I've basically begun a campaign to let people know that this is in fact a bad@as movie. This is now in my top 3 favorite movies: 28 days later, The Matrix (the first one), Priest.
Go see it, and don't let any of these reviews (including this one) effect what you think of it. If you like my top three, you like vampires, you like genre-benders and you don't need sex in a movie to think it's good, then you will like/love this flick.… Expand
Nov 4, 2011Priest is...a bad movie. But I enjoyed it, I thought it was rather entertaining and hilarious. It was, (shall I say), Soo-bad-it-was-good.
Jun 26, 2011I really didn't know what to expect with this movie. As soon as the movie began to play my eye instantly caught the aesthetic style of theI really didn't know what to expect with this movie. As soon as the movie began to play my eye instantly caught the aesthetic style of the world that this movie painted, and the back story that set the film's plot up was decent to boot. The CGI was decent and the acting wasn't terrible. The movie opened with the tale of a war with vampires and special warriors called priests tasked with stopping the vamps. After the vampire threat was long thought diminished they begin to return. After this interesting set-up the film shifts it's plot to more of a rescue mission. it completely loses the scope that it sets up at the beginning of the film and ends with a very lackluster climax that is unfortunately forgettable, which is pretty much what I'd say about the whole film itself. The story just didn't pan out very well ant the cool art direction was ditched after the first fifteen minutes of the movie, They had a really cool noire looking city in the middle of the desert and we barley got to see any of it. This movie could have been so much more, well at least the vampires didn't sparkle...… Expand
Sep 18, 2011"Priest" tries to tame the wild SF+horror+western genre with impressive CGI. Ultimately, the movie is what you will expect.
May 19, 2011Paul Bettany plays a holy man who's also a badass vampire killer. Unfortunately, the movie isn't badassâ
May 31, 2011In contrast to the glimmering, good-looking people vampires have been portrayed to be in recent movies/TV shows, the vampires portrayed inIn contrast to the glimmering, good-looking people vampires have been portrayed to be in recent movies/TV shows, the vampires portrayed in Priests are the complete opposite, and is pretty awesome. However the story was bland and some of the dialogues felt awkward. This movie seemed more like a straight to DVD, or a made for TV, type film. I would recommend that those who are thinking about watching this in theaters to skip it and pick it up for rental when it comes out.… Expand


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A spring green dinner can be quickly assembled, with the help of asparagus from the garden and a sauce of wild leeks, or ramps, for the evening's spaghetti. (CANDACE PAGE, Free Press) / CANDACE PAGE, Free Press
One glance over the steep bank of the twisty mountain road awakened my long-dormant forager's instincts as if an alarm clock had rung.
Broad green leaves carpeted a shelf of ground beside a tiny stream about 25 yards downhill.
Wild leeks? Sure looked like it.
I kept one eye scanning the distant plants — and seeking a route down the precipitous bank — while continuing to interview my local guide, the subject of a future Free Press story about his hill community.
It was Tuesday, a forenoon of cool air, sun, drifting clouds, the hills brushed with the lightest wash of spring green, a day to revel in being outdoors. When my interview concluded, I said goodbye, drove back up the road to a parking area, put on my hiking boots and grabbed my bag lunch.
My descent of the wooded hillside (on state-owned land) was more tumble than hike, but at the bottom I found myself beside a woodland lawn of wild leeks, their bright green lighting up the margins of a tiny stream.
With the help of a sturdy stick I pried one of the plants from the ground. Wild leeks resemble other broad-leafed forest plants, but this specimen had the purple stem and onion scent that made the identification sure.
I lunched amid the leeks, like Dorothy in the field of clover along the Yellow Brick Road.
Afterward, my harvest of about 15 plants left the huge plot virtually untouched. Overharvesting of wild leeks has become a problem in parts of Quebec and some southern states, so I deliberately took only a few plants. Climbing back to the road was easier than the descent. I headed back to Burlington and the rest of my workday.
Now, what to do with the leeks? The little bulbs have a strong, untamed garlicky flavor that I've found too strong in the past, so I was looking for help.
Turns out the plant's culinary popularity has populated the Web with endless recipes. (It's a good idea to use the term "ramps" for a Web search, as the name given to Allium tricoccum by Southern foragers is better known than wild leeks). I quickly settled on an old Gourmet magazine recipe for spaghetti with ramps, mainly because it did not require a trip to the grocery store.
At home, I reread the recipe and realized I did not know whether the ingredient "1/2 pound ramps" meant a half-pound of bulbs, or whether the greens also are edible. I tried a bite of leaf. It seemed tender and only mildly onion-y. (Later research confirmed that the young tops of wild leeks are, indeed, edible and tasty). I halved the recipe to accommodate the small quantity of leeks I had in hand, throwing in about half the green tops.
As the blender pureed the blanched leeks, my sauce turned a neon green that almost hurt the eyes. While the spaghetti cooked, I cut asparagus from our miniscule patch and cooked it briefly in the water used to blanch the leeks. Supper was on the table in less than half an hour.
Our dinner plates were as green and cheerful as the spring hills. Lemon juice on the asparagus and lemon zest in the wild leek pasta sauce added a bright, acidic note. The verdict: Can we have more?
This has been a mostly rainy, depressing spring in Vermont. For this one evening, in our kitchen, the sun was shining.
Spaghetti with Ramps
Serves 4.
Gourmet, April 2000
Note: It is not necessary to forage for your own wild leeks. They can be purchased in April and May at a number of local co-ops and natural food stores.
1/2 pound ramps (bulbs and tender leaves)
1 teaspoon finely grated fresh lemon zest
1/4 cup extra-virgin olive oil
1 pound spaghetti
2 tablespoons freshly grated Parmesan
1. Trim roots from ramps and slip off outer skin on bulbs if loose. Blanch ramps in a 6-quart pot of boiling salted water, 2 to 3 seconds, and transfer to a cutting board with tongs. Coarsely chop ramps and place in a blender with zest and oil.
2. Add spaghetti to boiling water and cook a few minutes, then ladle out 1/2 cup pasta water and add to blender. Puree ramps until smooth and season with salt. Continue to cook spaghetti until al dente, then ladle out about 1 cup additional pasta water before draining spaghetti in a colander. Return pasta to pot with ramp puree and toss with parmesan over moderate heat 1 to 2 minutes, thinning sauce with a little pasta water as needed to coat pasta.
(The Gourmet recipe includes a sprinkle of toasted breadcrumbs to the finished dish to add a bit of crunch).