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By Scott Stoddard, INVESTOR'S BUSINESS DAILY01/25/2013 05:36 PM ET
Nationstar Mortgage Holdings (NSM) is in a strong industry group and boasts healthy fundamentals. But its chart shows poor action following a promising breakout.
The mortgage servicer cleared a 37.30 buy point in huge volume on Jan. 7. But it's fallen for 10 of the past 12 sessions and as much as 9% below the entry.
Investors should sell any stock that falls 8% from their purchase price. So those who bought at the breakout may need to cut losses short.
Nationstar buys troubled mortgages from big banks seeking to cut costs and comply with tougher banking regulations. Nationstar earns fees from servicing the mortgages and has done well thanks to falling delinquency rates and a gradually improving economy.
Revenue growth has accelerated for three straight quarters, tripling in the latest period. Profit growth has been similarly strong.
But like many stocks connected to the housing industry, Nationstar is a turnaround play. The company posted its first profit in five years in 2011 and is expected to report that earnings soared 926% in the year just ended.
Nationstar enjoys a best-possible 99 Composite Rating, putting it on par with rival Ocwen Financial (OCN), an IBD 50 stock that's forming a base. Both are in the Finance-Mortgage & Related Services industry group, which was ranked No. 4 out of the 197 groups as of Friday's IBD.
Nationstar went public in March and more than doubled over the next seven months before shaping its latest base.
The stock's pullback has come in mostly weak volume. But its persistent weakness in the face of a climbing market is a worry, not to mention its sell signal.
Investors upbeat about Nationstar should watch for a new base to take shape.
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Mine? 52.381. 4th level test 2.
Phew. Believe it or not, I actually thought it was worse, like a 48%....but nope, I looked it up. Maybe the 48 was a schooling show
I also got an appallingly low score for a 3Day dressage test in college where my schoolhorse left the arena twice, but I don't recall the exact number and thankfully can't find any scores going back that long ago

subset: commoncrawl


text: Posted 31 Jul 2013 · Report post Hi everyone, I got some labwork back today, and it turns out my vitamin D is low (it's 28, the doctor said it needs to be at least 60). The doctor prescribed a high dosage of D2, 50,000 twice a week. That's a total of 100,000 IU/ week for 2-3 months. Is that a lot? I'm worried about possible toxicity and side effects. The doctor said she will be monitoring my levels every 2 months to make sure I'm not taking more than I need, but for now she thinks it's crucial to megadose on D2. What do you think? Should I break the 50,000 IU pill in half so I won't have to take 50,000 all at once? Not sure how to split the dosage, and if biweekly is the way to go as the doctor recommended. Also, any time I tried to supplement with D3 (couldn't find D2), my face broke out....I'm guessing because of the oil or fat that makes the supplement soluble. Do you think there's a chance of breaking out with D2 like I did with D3 supplements? The doctor thinks D2 will be more easily absorbed than D3 and shouldn't cause any problems. Share this post Link to post Share on other sites


text:
General Info
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Trade Shows | April 17, 2013
The best and brightest new talents make the cut for Salone Satellite, the younger sibling of the main Salone fair in Milan. Catch a glimpse of product highlights shown at the 16th edition last week. Video produced by Dario Ghezzi and edited by James Eades.


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November 28, 2015
WASHINGTON (AP) - The ladies of ABC's "The View" are getting a special guest next Tuesday: Vice President Joe Biden.
The vice president's office says he'll appear on the daytime talk show to encourage people to sign up under the government's new health insurance program.
The White House has a lot of work ahead to reach its unofficial goal of getting 7 million people to sign up by the end of March.
Nearly 3.3 million people signed up between Oct. 1 and Feb. 1.
Biden also is appearing on Monday's premiere of NBC's "Late Night" with Seth Meyers as the program's new host.
Copyright 2015 Associated Press. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.
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Texas shortstop Elvis Andrus takes a swing during the Texas Rangers vs. the Colorado Rockies spring training game in Scottsdale, AZ on Monday, February 25, 2013. (Louis DeLuca/The Dallas Morning News)
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text: Hit the Road, Jack: New England Summer Road Trip Ideas Submitted On June 16, 2014 Load up the car, folks! It's summertime in New England, which means a classic New England road trip is in order. Whether you're craving the rock faces of the White Mountains, the sandy shores of Cape Cod, or the rolling hills of Vermont, one of these a classic summer road trip ideas through New England is sure to get your engine revving on high. Check out these three New England road trip ideas, complete with suggestions for things to do and places to stay in New England. Skier's Highway: Vermont Summer Roadtrip Regardless of the season, a Vermont road trip up Route 100 features scenic views, New England charm, amazing outdoor activities, and delectable local gastronomy. Nicknamed the "Skier's Highway," the scenic byway offers just as many fun diversions in the summer and leads travelers up the spine of the Green Mountains from Wilmington to Stowe, Vermont. A southern Vermont inn like the the White House Inn makes a good starting point in Wilmington, VT. Pick up Route 100 in the center of town, and head north, stopping for a hike up Stratton Mountain or a walk around Grout Pond. If you get to Weston, VT, early enough, visit the original Vermont Country Store before stretching your legs in town (look for its two waterfalls). End the evening with dinner and some well-earned relaxation at The Inn at Weston. On day two, take a detour from Route 100 to visit Woodstock, VT, then continue on north and make a stop in the teeny-tiny town of Warren, VT for a hike up Mount Abraham or to call it a night at the West Hill House B&B. Finish your northern journey by staying (or collapsing) at a Stowe bed and breakfast. With terrific food and entertainment in this renowned Vermont mountain town, it's the cherry on top of a Route 100 road trip. If you're looking to venture farther up through Vermont, head into the Northeast Kingdom, or hang a left for a weekend in Burlington. Coastal Cruise: New Hampshire Seacoast, then Down the Cape There's nothing quite like a road trip along the rocky coastal cliffs and smooth sand beaches of New England. A fan suggested this road trip route on our Facebook page, and we thought it would be great to share with everyone! Start off up north with a stay at a New Hampshire Seacoast resort: Wentworth By the Sea. Enjoy all that Portsmouth, NH, has to offer (unique boutiques and shops, a skilled brewery, interesting history) before continuing south along the Altlantic shoreline to Cape Ann, MA. Spend the second night in Rockport, MA — there are several options for places to stay, plus wonderful restaurants serving the freshest of New England seafood. Keep the road trip momentum going by heading through Boston next. As the big city of coastal New England, a day spent in Boston is a chance to do something special: visit the huge New England Aquarium, then grab a cone at Emack & Bolio's Ice Cream, and before catching a Red Sox game. Save the driving for the next day, and pick a hotel in downtown Boston for a night close to the water yet close to the culture. The last leg of this classic New England road trip takes you farther south and out to Cape Cod. A vacation "down the cape," as locals say, allows for fantastic beach time, with a hearty dose of New England summer culture. End your summer road trip with a night's stay (or two) at an inn in Provincetown, MA, the farthest point out on the Cape and a vibrant summer city to boot. The Nor'easterner Roadtrip: Six New England States in One Incredible Road Trip The truly valiant New England road tripper can take on The Nor'easterner Road Trip, a six state sojourn combining all the best of Connecticut, Rhode Island, Massachusetts, Maine, New Hampshire, and Vermont. Starting in coastal Connecticut, follow I-95 along the Long Island Sound to explore Connecticut's beaches. Need a little extra time as a beach bum? Look for a Connecticut shore resort like the Madison Beach Hotel or Water's Edge Resort & Spa. Next, leave I-91 behind and head northeast to explore Rhode Island. You can spend a whole weekend in Newport, RI, or head up to Providence and get a feel for this historic New England city. Continuing north, the more urban-minded road trippers will find plenty of things to do in Boston (see our Coastal Cruise Road Trip), before moving on to New Hampshire's seacoast and into Maine. Both Kennebunkport and Portland, ME, are good options for that night's stay: catch the laid-back, coastal town vibe of downeast Maine in the Kennebunks, or eat your way through Portland, one of the East Coast's most foodie-friendly cities. After you've had your fill, road trip on over to the White Mountains, where you'll want to stay in North Conway or Jackson, NH — spend an elegant & intimate evening at The Wentworth or try the Red Jacket Mountain View Resort for an incredible vantage point (and some lighthearted fun at the waterpark). Either make for great base camps from which to explore the very best of New England hiking, by summiting one of the Presidentials, or enjoying the incredible Franconia Ridge. Once you're tuckered out from hiking the Whites, it's time to head southwest to the Vermont! Travel through the I-91 corridor (again) and head south, stopping for a brew at the Norwich Inn before crossing the Green Mountains for a night in Manchester, VT. Cross the epic road trip finish line back in Massachusetts, stopping in the Berkshires as you make your way back home. Happy Trails! So what are you waiting for? Whatever driveway you're pulling out of, it's time to hit the road and take to New England for an original summer road trip. Feel free to follow these itineraries, or mix and match them to come up with your own road trip ideas. Enjoy! Photos: Maine Office of Tourism; Vermont Department of Tourism & Marketing; Inn at Weston; Cape Cod Chamber of Commerce/Matt Suess; Discover New England; Water's Edge Resort & Spa; White Mountains Attractions.


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Posted on 12.12.2013
Trading Internet options doesn't have to be difficult as long as you take the time to learn the right strategies an the ways that stock options can most benefit you and your portfolio.
Stock options trading offers investors a chance for a big payoff, yet with different limitations compared to other investment opportunities. Buying an option gives you the choice to invest, but doesn't obligate you in the same way as other speculations. For example, when you see Internet options that seem like they might increase your initial investment, you can set an agreed-upon expiration date within your contract. Then, if the underlying asset isn't performing like you'd hope, you can simply let the expiration date go buy, losing only your initial investment.
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Posted on 25.12.2013
With the right Internet options trading strategies, you have a much better chance of getting Internet options to work in your favor. Here's a look at five of the most common.


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Harry Short's latest attempt to engage Bible believers ("Flaws in letter about history," March 9) comes in an attack on the inaccurate calendar used in the past concerning the birth date of Jesus Christ.
Calendars, however, are not inspired by God and do not have any relevance to the fact that Jesus was born. Our calendar has been changed several times and by various people such as Julius Caesar, Caesar Augustus and Pope Gregory. In America, the calendar was last changed in 1752, when Sept. 3 was followed by Sept. 14. Eleven days were dropped.
Somehow the question of the exact date of Christ's birth and Mr. Short's discovery that we have ". . . come to realize through the recent abundance of space exploration, there is really no such thing as a God . . .," leads him to want to change our currency. Therefore he concludes that, "In God We Trust" should be changed to "In Science We Trust."
I must admit the logical flow of thought to Mr. Short's conclusion escapes me.
The most important element of Christ's ministry is not when he was born, but rather that he died for our sin, rose from the dead on the third day and sits in the presence of God the father forever more. Second, in spite of all that we have learned in space exploration, we have more questions now than before we began exploring. To say that there is no God based on the little that we know about outer space, is like taking a cup of water from off the dock in Suisun City and declaring there are no whales. Third, if you plan to question the faith of others, please tighten your logic. There appears to be a few bolts loose from Mr. Short's general premise to his conclusion.
The Rev. Art Zacher
Berean Baptist Church
The Daily Republic does not necessarily condone the comments here, nor does it review every post. Please read our Terms of Service and Privacy Policy before commenting.
Yes, he has the few bolts loose. Not the person who believes a woman was made from a rib and took advice from a talking snake.Reply |
THIS LOOKS LIKE A PRIVATE FIGHT. WILL STAY OUT OF IT. NO ONE WILL WINReply |
Patrick, it would be best for you to remain on the sidelines because it is over. I clearly presented the best case there is no legal or moral argument.Reply |
That's right, Patrick... put a fork in 'em, Seedy is done!Reply |
The Mister, really? How so? You've brought nothing of value to these arguments, you have zero. Looks to me like it is you and yours that are done. You should hook up with teach5th. Good evening.Reply |
Daily Republic is also trolling here. I love the title they gave this letter.Reply |
Cults given press space.Reply |
Pastor Zacker, rather than wasting time and space on this nonsense, I wish you would have spoken out against the travesty of prejudice in the name of your god. Oh yeah, guess that would have been a conflict of interest? Pathetic.Reply |
CD do you care to defend the atrocities commited by your side, secular atheists? Stalin, Mao, Pot Pol and Hitler murdered more humans than all the religious wars combined, defend those recent events and I'll explain again what the thousand year old Crusades and Inquisition were about.Reply |
And don't forget the "science" of eugenics, the "science" of phrenology, the "science" of sexology pioneered by Alfred Kinsey to promote pedophilia, the "science" of bloodletting to rid the body of bad humors", and on and on and on.Reply |
Daniel, I am defending American citizens civil and human rights as recognized by law. I never said I condone any atrocities. Stop being ridiculous and man-up to your willingness to hate under the guise of religion. You people make me angry that there is no hell.Reply |
CD - we get it already! You don't believe in God. As I wrote recently, your god (Obama) and your religion (big government) are doing far more harm to people than organized religion is doing. Other than that little group of haters who protest at soldiers' funerals, what are you talking about specifically as far as Christianity harming folks? Please enlighten me.Reply |
Teach5th, are you for real? I've wasted enough time exposing the hypocrisy, stupidity and hate here. If you don't get it by now, your grasp of reality beyond any intelligent reasoning. Good grief.Reply |
Cd- good job explaining . . . You've got nothing specific. That's your problem. You call Christians haters and say they do harm, yet asked for specificity, you have nothing. So, who's the real hater?Reply |
teach5th, either you're a complete imbecile or you're attempting the most bizarre deflection ever! I have written hundreds if not thousands of words on this subject in this publication over the past weeks. I have warned about those events happening for years here and you want ME to spell it out?! I'm going to research your alleged credentials, you have no business teaching.Reply |
Yep - name calling and threats. Nothing more. I don't have the luxury of reading your rants on a daily/weekly basis. I ask for specifics and you deflect by saying you've already written and warned about them. Maybe you're not writing them because they're not worth repeating.Reply |
Teach5th, wow...you are a lot of things but teacher isn't one of them.Reply |
Oh Seedy, you are starting to sound more like a lying politician with an agenda with every post. Come on Seedy... reality has got room for one more.Reply |
C'mon The Mister, you know I'm not lying and you have zero information to disprove me. You have referenced emails that have been circulating with added variations since 2009 and have been shown repeatedly to be false. My agenda is getting the truth out to those of you going the wrong direction. But alas, I have failed.Reply |
Not sure what you're talking about, yet again, Seedy. This is what I said, "And don't forget the "science" of eugenics, the "science" of phrenology, the "science" of sexology pioneered by Alfred Kinsey to promote pedophilia, the "science" of bloodletting to rid the body of bad humors", and on and on and on." These are all sciences that have harmed or killed people that today scientists view as hokum. Some are exceedingly dangerous, such as eugenics, as this science was responsible for learned governments to commit democide with hundreds of millions of victims in the last century. The science of global warming stands to back a global tax to the UN enforceable by UN troops on US soil. Tell me you think this science will be a help to humanity as its tyranny plays out.Reply |
The Mister, I never spoke to those issues, and frankly have no idea what they are. Like I said...again, I do not condone any atrocities. I wrote specifically about the ones going on in other states.Reply |
Good job, CD - once again - deflect, deflect, deflect! (Oh, and threaten):)Reply |
@Teach: Bologna! You are projecting a false reality, then asking CD to comment on this false reality. When he doesn't, you claim he is deflecting. Great method of putting words in someones mouth. Obama is a Christian, so I guess we can chalk you up as a Christian hater? See how that works.Reply |
Teach5th, okay let's see where you go with this…On March 15th (that would be yesterday) at 10:35 AM you responded to my "putrid things" comment and addressed zero of what I wrote about JUST ABOVE your comments. You completely ignored the basis of my comments where I specifically addressed the flagrant attempts in AZ and KS to legislate legal discrimination. So are you a li*r or ign*rant? Or would you just prefer not to show your prejudicial side by agreeing with those and other states position on the matter? If you're going to challenge me you'd better be right. I'm always prepared! Deflect that!Reply |
CD - I don't make copies of these dialogues. Consequently, I don't remember what you wrote (except the putrid comments and sneaking away like a thief in the night. Therefore, I can't address your concerns about AZ or KS. I can only say that, while humans have used religion in the past to punish those who don't think like they do, it's not only religious folks that do that. Look, for example, at your post to me earlier that because I don't believe in your god (Obama) or your religion (big government) you threatened to "research my alleged credentials" since, according to you I " had no business teaching. Weren't you threatening my livelihood just as those in Az are feeling about the government threatening theirs?Reply |
Teach5th, you are truly a complete...I'm too much a gentleman to continue. I don't threaten people. There is no good reason to converse with you further on this matter. Good evening.Reply |
CD - you are delusional! I didn't threaten to look up your credentials! You said that to me. Good night!Reply |
@Teach5th, I believe that the credential blurb was an insult, not a threat. It would be a threat if you didn't have credentials and would thereby be exposed. Mr. Brooks wording was insulting, not threatening. Even it it were a threat, it was an empty one, as he really can't look up the credentials to "Teach5th" unless that is actually your name. It would be more accurate to complain that he was insulting you.Reply |


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The aim of our study was to analyze the influence of the CCR5Δ32 polymorphism in the risk of cardiovascular (CV) events and subclinical atherosclerosis among patients with rheumatoid arthritis (RA).
A total of 645 patients fulfilling the American Rheumatism Association 1987 revised classification criteria for RA were studied. Patients were genotyped for the CCR5 rs333 polymorphism using predesigned TaqMan assays. Also, HLA DRB1 genotyping was performed using molecular-based methods. Carotid intima-media thickness, flow-mediated endothelium-dependent dilatation (FMD) and endothelium-independent vasodilatation, which were used as surrogate markers of subclinical atherosclerosis, were measured in a subgroup of patients with no clinical CV disease.
A lower frequency of carriers of the CCR5Δ32 allele among patients with CV events (3.4% versus 11.3%, P = 0.025, odds ratio 0.28, 95% confidence interval (95% CI) 0.06 to 0.89) was observed. However, after adjusting for gender, age at time of RA diagnosis, and the presence of shared epitope, rheumatoid factor and classic CV risk factors in the Cox regression analysis, this reduction of CV events in CCR5Δ32 allele carriers was slightly outside the range of significance (P = 0.097; hazard ratio 0.37 (95% CI 0.12 to 1.19)). Carriers of the CCR5Δ32 deletion also showed higher FMD values than the remaining patients (CCR5/CCR5Δ32 patients: 7.03% ± 6.61% versus CCR5/CCR5 patients: 5.51% ± 4.66%). This difference was statistically significant when analysis of covariance was performed (P = 0.024).
Our results show a potential influence of the CCR5Δ32 deletion on the risk of CV disease among patients with RA. This may be due to a protective effect of this allelic variant against the development of vascular endothelial dysfunction.
Keywords:rheumatoid arthritis; atherosclerosis; cardiovascular disease; genetics; CCR5Δ32; rs333
CCR5 is a G protein-coupled receptor that is expressed on macrophages, monocytes, Th1 cells, immature dendritic cells, endothelial cells and vascular smooth muscle cells (VSMCs) [1-4]. The activation of this molecule through one of its ligands contributes to the survival and accumulation of macrophages [5] during inflammation, to the recruitment and activation of T cells [6] and to the activation and secretion of tissue factor [2] of VSMCs. It also participates in osteoclast formation [1]. Consistent with its roles, CCR5 is considered to play a role in both rheumatoid arthritis (RA) and atherosclerosis [7].
The CCR5Δ32 (dbSNP rs333) polymorphism is defined by a 32-bp deletion that leads to a truncated nonfunctional receptor [8], which is eliminated from the cell surface in homozygous individuals or its expression is reduced by 20% to 30% in heterozygous individuals [9]. Several studies have demonstrated a protective effect of the CCR5Δ32 allele in patients with CV disease [10,11], although others have demonstrated no association [12-14].
CCR5Δ32 deletion also was suggested to have a protective effect on RA susceptibility in a Spanish cohort [15]. Although other studies could not confirm a protective effect of this variant [16], a meta-analysis has suggested a protective effect [17]. When the influence of the CCR5Δ32 polymorphism and disease severity were analyzed, conflicting results were reported [16,18]. These contradictions may be the result of differences in study design, study power or the populations assessed; therefore, additional data will be helpful to understand the role of CCR5 gene polymorphisms. Taking all of these considerations together, the aim of the present study was to analyze the influence of the CCR5Δ32 polymorphism on the risk of CV events and subclinical atherosclerosis in patients with RA.
Materials and methods
Patients and study protocol
Between March 1996 and March 2008, 660 consecutive patients who fulfilled the American Rheumatism Association 1987 revised classification criteria for RA [19] were recruited from the rheumatology outpatient clinics of Hospital Xeral-Calde (Lugo, Spain) and Hospital Clínico San Carlos (Madrid, Spain). DNA samples were extracted from these patients at the time of recruitment. Between December 2009 and January 2010, patients' clinical records were examined until death, loss of follow-up or 1 December 2009. Sociodemographic and clinical data regarding clinical manifestations, classic CV risk factors and history of CV events were registered. Clinical definitions for CV events and classic CV risk factors were established as previously described [20,21]. Information on the main demographic characteristics, CV risk factors and CV events of patients in whom genotyping success was achieved (n = 645 (97.7%)) is shown in Table 1. Hospital Xeral-Calde and Hospital Clinico San Carlos are the referral centers for the population of each respective area. The first CV event was defined as an event (case) of CV complication diagnosed at the hospital in a patient without a history of CV disease.
Table 1. Demographic characteristics and genotype distribution of the patients with rheumatoid arthritis included in the studya
Endothelial dysfunction was assessed between March 2007 and September 2009 in a random subgroup of patients in the Lugo cohort with no history of CV disease. Flow-mediated endothelium-dependent vasodilatation FMD (postischemia) and endothelium-independent vasodilatation NTG (postnitroglycerin) were assessed on the basis of a brachial artery reactivity study in 127 patients as previously reported [22,23]. Intraobserver variability was 1.3% and 1.9%, respectively, based on repeat ultrasonography in 32 healthy controls. Assessment of the endothelial function of patients undergoing anti-TNF therapy was performed 24 to 48 hours before drug administration. Carotid artery intima-media thickness (IMT) was determined in 105 patients as previously reported [23,24]. The correlation coefficient was 0.98 based on repeat ultrasonography in 20 RA patients and 20 healthy controls. Participants' written consent was obtained according to the Declaration of Helsinki, and the design of the study was approved by the Ethics Committee of Galicia (Spain) and the Hospital Clinico San Carlos (Madrid).
CCR5 genotyping
DNA from patients was obtained from whole peripheral blood using standard methods. Participants were genotyped to determine CCR5 status using TaqMan Assays-on-Demand from Applied Biosystems following the manufacturer's protocol and analyzed using the Applied Biosystems 7900 HT Fast Real-Time PCR System (Applied Biosystems, Foster City, CA, USA). The typing was successful in 645 patients (97.7%). Ten percent of the samples were regenotyped at random. We observed no differences from the results obtained before.
Shared epitope determination
Several HLA-DRB1 alleles are associated with susceptibility to RA, encoding a conserved amino acid sequence at positions 70 to 74 in the third hypervariable region, called the "shared epitope" [25]. HLA DRB1 typing was carried out using a reverse dot-blot kit with sequence-specific oligonucleotide probes (Dynal RELI SSO HLA-DRB1 Typing Kit; Dynal Biotech, Bromborough, UK). In our sample, 63.2% of the patients had at least one copy of the rheumatoid shared epitope, a frequency higher than that found previously in Spanish individuals without RA [26].
Statistical analysis
Comparison of means was performed using a t-test. Comparison of proportions between two or more groups was carried out using a χ2 test or Fisher's exact test when required. Hardy-Weinberg equilibrium (HWE) was tested in the RA patients with and without CV disease. Both groups were in HWE (P = 0.87 and P = 0.93, respectively). The study had 80% power for detecting an odds ratio (OR) ≥ 2. A Cox regression model was used to estimate the influence of the CCR5 polymorphism on CV disease. We used the occurrence of at least one CV event as the outcome. Survival time was defined as "age of the subjects at" or "elapsed time between RA diagnosis and" the first CV event, patient's death, loss of follow-up or 1 December 2009. Patients who died as a result of any cause other than CV events were considered not to have had CV events. Proportional hazards assumptions were tested using Schoenfeld residuals. The results are expressed as hazard ratios (HRs) with 95% confidence intervals (95% CIs) and were computed as both crude analysis and adjusted for age at RA diagnosis, gender and classic CV risk factors. The selected variables used for adjustment were selected on the basis of their association with the outcome (CV event) and the exposure (CCR5 genotype) and because they produced a change > 10% in the HR.
The association between CCR5Δ32 and carotid IMT, FMD and NTG was also tested using analysis of covariance (ANCOVA) adjusting for gender, age and duration of the disease at the time of ultrasonography as well as for the presence or absence of the shared epitope and traditional CV risk factors. This study had 80% power to detect a difference in carotid IMT of 0.1 mm or higher, a difference of 2.5% or higher in FMD and a difference of 3.5% or higher in NTG. Statistical significance was defined as P ≤ 0.05. Calculations were performed with Stata version 10 software (StataCorp LP, College Station, TX, USA).
Influence of the CCR5Δ32 polymorphism on the risk of cardiovascular events
We compared the genotypic and allelic frequencies of the CCR5Δ32 polymorphism between the subgroups of RA patients with and without CV events (Table 2). We found a decreased frequency of carriers of the deletion (CCR5/CCR5Δ32 + CCR5Δ32/CCR5Δ32) among the patients with CV events (3.4% versus 11.3%, P = 0.025, OR 0.28 (95% CI 0.06 to 0.89)). Likewise, the CCR5Δ32 allele frequency was also decreased among the RA patients with CV events (1.7% versus 5.8%, P = 0.024, OR 0.28 (95% CI 0.06 to 0.88)).
Table 2. Differences between rheumatoid arthritis patients with or without cardiovascular events according to CCR5Δ32 polymorphisma
We performed Cox regression analysis to account for the variation of risk of the first CV event over time according to the CCR5Δ32 variant, assuming a dominant model of effect (carriers versus noncarriers of the deletion) (Table 3). When age was used as a measure of survival time, to carry at least a copy of the CCR5Δ32 allele was not associated with a lower risk of CV disease over time, in both the crude and adjusted analyses (P = 0.14 and P = 0.14, respectively). When elapsed time from RA diagnosis was used, the reduction of CV events in carriers was slightly outside the range of significance in the crude analysis (P = 0.078, HR 0.35 (95% CI 0.11 to 1.12)) and in the adjusted analysis (P = 0.097, HR 0.37 (95% CI 0.12 to 1.19)).
Table 3. Cox regression model to estimate the influence of the CCR5Δ32 polymorphism in the risk of cardiovascular disease in patients with rheumatoid arthritisa
Influence of the CCR5Δ32 polymorphism in subclinical atherosclerosis
Owing to the small number of homozygotes for the CCR5Δ32 deletion, none of those patients underwent ultrasonography for the assessment of subclinical atherosclerosis. Therefore, the comparisons were performed between heterozygote and homozygote subjects with two copies of the allele without the 32-bp deletion. In the unadjusted analysis, we did not observe a significant difference regarding carotid IMT, FMD or NTG (P = 0.32, P = 0.28 and P = 0.64, respectively) (Table 4). However, in the adjusted ANCOVA, we observed a significant association between being heterozygous for the CCR5Δ32 deletion and a higher FMD (P = 0.024) (Table 5). In this regard, the mean FMD percentage among heterozygotes was higher than in those without the allelic variation (7.03% ± 6.61% versus 5.51% ± 4.66%, respectively). Interestingly, the mean FMD percentage among heterozygous patients was considered normal [23].
Table 4. Comparison of carotid artery intima-media thickness, flow-mediated endothelium-dependent (postischemia) vasodilatation and endothelium-independent vasodilatation according to the CCR5Δ32 polymorphism distributiona
Table 5. Comparison of carotid artery intima-media thickness, flow-mediated endothelium-dependent (postischemia) vasodilatation and endothelium-independent vasodilatation according to a recessive pattern of effect of CCR5Δ32 polymorphism in an analysis of covariance modela
This study is the first to address the role of the CCR5Δ32 deletion in the risk of CV disease in RA patients. We observed a lower frequency of this variant among the patients with CV complications. However, in the Cox regression model, the potential protective role of the CCR5Δ32 deletion was slightly outside the range of significance. Regarding the surrogate markers of subclinical atherosclerosis, we observed that RA patients with a copy of the CCR5 allele containing the 32-bp deletion had a higher FMD value. In fact, the mean FMD value in those patients was over the cutoff point for normal endothelial function observed in our echocardiography laboratory. These observations suggest a protective effect of the CCR5Δ32 deletion against the development of endothelial dysfunction, an early step in the atherogenic process, in patients with RA. Although no association of CCR5Δ32 deletion with carotid IMT was observed in our series, a significantly lower carotid IMT in the common carotid artery was found in individuals carrying the CCR5Δ32 deletion in the Bruneck study [27], which is a prospective population-based survey of the epidemiological pathogenesis of atherosclerosis. Since FMD constitutes a physiologic assessment of endothelial dysfunction and carotid IMT is an anatomic structural measure of subclinical atherosclerosis, it is logical that FMD might be a more useful diagnostic marker than carotid IMT in the early stages of the disease. In this regard, no relationship between carotid IMT and brachial artery FMD was found in middle-aged men without a history of CV disease who were considered to be at low or intermediate risk for future CV events based on current risk stratification algorithms [28]. Brachial FMD and carotid IMT values may indicate distinct and independent stages in the complex pathways leading to accelerated atherosclerosis in patients with RA. It was recently reported that, in patients with RA without CV disease, the association between FMD and carotid IMT values was observed only in patients with long disease duration [29].
As we pointed out in the Introduction, CCR5 seems to play an important role in the development of atherosclerosis. In rodent knockout models, the lack of CCR5 was associated with a reduction in plaque formation and macrophages, Th1 and smooth muscle cell accumulation, and increased expression of anti-inflammatory cytokines such as IL-10 [4,30,31]. Furthermore, studies using an antagonist of the CCR5 and CXCR3 chemokine receptors [32] or a recombinant RANTES (regulated upon activation, normal T cell expressed and secreted) receptor antagonist [33] have demonstrated an attenuation of atherogenesis in low-density lipoprotein receptor-null mice. In humans, the presence of the CCR5Δ32 deletion, when associated with lower or even absent expression of the CCR5 molecule on the cell surface [9], has also been associated with a lower risk of CV disease in some studies [10,11]. In the present study, we observed better endothelial function in response to ischemia among those RA patients carrying the CCR5Δ32 deletion. However, this fact was not associated with a strong reduction in the risk of CV disease. Since endothelial dysfunction is an early step in the atherogenic process, these observations might appear to be contradictory. However, RA is a chronic inflammatory disease, and it is well known that the persistence of chronic inflammatory burden is of major importance in the development of CV events in these patients [20]. Because of that, it is possible that a chronic inflammatory status might overcome the potential protective effect that the CCR5Δ32 deletion may have against the progression of the atherogenic process.
In summary, our results show a potential influence of the CCR5Δ32 deletion on the risk of CV disease in patients with RA. This may be due to a protective effect of this allelic variant against the development of vascular endothelial dysfunction. However, further studies need to be carried out to replicate our findings and confirm the role of this molecule in the atherosclerosis disease observed in patients with RA.
ANCOVA: analysis of covariance; anti-CCP: anti-cyclic citrullinated peptide antibodies; bp: base pair; CI: confidence interval; CV: cardiovascular; FMD: endothelium-dependent flow-mediated vasodilatation (postischemia); HLA: human leukocyte antigen; HR: hazard ratio; IMT: intima-media thickness; NTG: endothelium-independent (postnitroglycerin) vasodilatation; RA: rheumatoid arthritis; RF: rheumatoid factor; TNF: tumor necrosis factor.
Competing interests
The authors declare that they have no competing interests.
Authors' contributions
LRR and MGB carried out genotyping, participated in the design of the study and the data analysis, and helped to draft the manuscript. CGJ performed the ultrasonographic studies, participated in the design of the study and the data analysis, and helped to draft the manuscript RPM participated in genotyping and data analysis. TRV, JAMF and LR participated in the acquisition and interpretation of data. BF was involved in the acquisition and interpretation of data and in revising it critically for important intellectual content. JM and MAGG made substantial contributions to the conception and design of the study, the acquisition of data, study coordination, helped to draft the manuscript, and gave final approval of the version to be published. All authors read and approved the final version of the manuscript for publication. MAGG and JM share senior authorship of this manuscript.
This study was supported by two grants from "Fondo de Investigaciones Sanitarias" PI06-0024 and PS09/00748 (Spain). This work was partially supported by the RETICS Program, RD08/0075 (RIER) from the "Instituto de Salud Carlos III" (ISCIII).
Oba Y, Lee JW, Ehrlich LA, Chung HY, Jelinek DF, Callander NS, Horuk R, Choi SJ, Roodman GD: MIP-1α utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells.
Exp Hematol 2005, 33:272-278. PubMed Abstract | Publisher Full Text
Schecter AD, Calderon TM, Berman AB, McManus CM, Fallon JT, Rossikhina M, Zhao W, Christ G, Berman JW, Taubman MB: Human vascular smooth muscle cells possess functional CCR5.
J Biol Chem 2000, 275:5466-5471. PubMed Abstract | Publisher Full Text
Lucas AD, Greaves DR: Atherosclerosis: role of chemokines and macrophages.
Expert Rev Mol Med 2001, 3:1-18. PubMed Abstract | Publisher Full Text
Oppermann M: Chemokine receptor CCR5: insights into structure, function, and regulation.
Cell Signal 2004, 16:1201-1210. PubMed Abstract | Publisher Full Text
Tyner JW, Uchida O, Kajiwara N, Kim EY, Patel AC, O'Sullivan MP, Walter MJ, Schwendener RA, Cook DN, Danoff TM, Holtzman MJ: CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection.
Nat Med 2005, 11:1180-1187. PubMed Abstract | Publisher Full Text
Crane IJ, Xu H, Wallace C, Manivannan A, Mack M, Liversidge J, Marquez G, Sharp PF, Forrester JV: Involvement of CCR5 in the passage of Th1-type cells across the blood-retina barrier in experimental autoimmune uveitis.
J Leukoc Biol 2006, 79:435-443. PubMed Abstract | Publisher Full Text
Zhao Q: Dual targeting of CCR2 and CCR5: therapeutic potential for immunologic and cardiovascular diseases.
J Leukoc Biol 2010, 88:41-55. PubMed Abstract | Publisher Full Text
Samson M, Libert F, Doranz BJ, Rucker J, Liesnard C, Farber CM, Saragosti S, Lapouméroulie C, Cognaux J, Forceille C, Muyldermans G, Verhofstede C, Burtonboy G, Georges M, Imai T, Rana S, Yi Y, Smyth RJ, Collman RG, Doms RW, Vassart G, Parmentier M: Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene.
Nature 1996, 382:722-725. PubMed Abstract | Publisher Full Text
Pacheco SE, Gibbs RA, Ansari-Lari A, Rogers P: Intranasal immunization with HIV reverse transcriptase: effect of dose in the induction of helper T cell type 1 and 2 immunity.
AIDS Res Hum Retroviruses 2000, 16:2009-2017. PubMed Abstract | Publisher Full Text
González P, Alvarez R, Batalla A, Reguero JR, Alvarez V, Astudillo A, Cubero GI, Cortina A, Coto E: Genetic variation at the chemokine receptors CCR5/CCR2 in myocardial infarction.
Genes Immun 2001, 2:191-195. PubMed Abstract | Publisher Full Text
Szalai C, Duba J, Prohászka Z, Kalina A, Szabó T, Nagy B, Horváth L, Császár A: Involvement of polymorphisms in the chemokine system in the susceptibility for coronary artery disease (CAD): coincidence of elevated Lp(a) and MCP-1 -2518 G/G genotype in CAD patients.
Atherosclerosis 2001, 158:233-239. PubMed Abstract | Publisher Full Text
Petrkova J, Cermakova Z, Lukl J, Petrek M: CC chemokine receptor 5 (CCR5) deletion polymorphism does not protect Czech males against early myocardial infarction.
J Intern Med 2005, 257:564-566. PubMed Abstract | Publisher Full Text
Apostolakis S, Baritaki S, Kochiadakis GE, Igoumenidis NE, Panutsopulos D, Spandidos DA: Effects of polymorphisms in chemokine ligands and receptors on susceptibility to coronary artery disease.
Thromb Res 2007, 119:63-71. PubMed Abstract | Publisher Full Text
Ghilardi G, Biondi ML, Turri O, Pateri F, D'Eril GM, Scorza R: Genetic control of chemokines in severe human internal carotid artery stenosis.
Cytokine 2008, 41:24-28. PubMed Abstract | Publisher Full Text
Gómez-Reino JJ, Pablos JL, Carreira PE, Santiago B, Serrano L, Vicario JL, Balsa A, Figueroa M, de Juan MD: Association of rheumatoid arthritis with a functional chemokine receptor, CCR5.
Arthritis Rheum 1999, 42:989-992. PubMed Abstract | Publisher Full Text
Kohem CL, Brenol JC, Xavier RM, Bredemeier M, Brenol CV, Dedavid e Silva TL, de Castilhos Mello A, Cañedo AD, Neves AG, Chies JA: The chemokine receptor CCR5 genetic polymorphism and expression in rheumatoid arthritis patients.
Scand J Rheumatol 2007, 36:359-364. PubMed Abstract | Publisher Full Text
Prahalad S: Negative association between the chemokine receptor CCR5-Δ32 polymorphism and rheumatoid arthritis: a meta-analysis.
Genes Immun 2006, 7:264-268. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Garred P, Madsen HO, Petersen J, Marquart H, Hansen TM, Freiesleben Sørensen S, Volck B, Svejgaard A, Andersen V: CC chemokine receptor 5 polymorphism in rheumatoid arthritis.
J Rheumatol 1998, 25:1462-1465. PubMed Abstract
Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, Medsger TA Jr, Mitchell DM, Neustadt DH, Pinals RS, Schaller JG, Sharp JT, Wilder RL, Hunder GG: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis.
Arthritis Rheum 1988, 31:315-324. PubMed Abstract | Publisher Full Text
Gonzalez-Gay MA, Gonzalez-Juanatey C, Lopez-Diaz MJ, Piñeiro A, Garcia-Porrua C, Miranda-Filloy JA, Ollier WE, Martin J, Llorca J: HLA-DRB1 and persistent chronic inflammation contribute to cardiovascular events and cardiovascular mortality in patients with rheumatoid arthritis.
Arthritis Rheum 2007, 57:125-132. PubMed Abstract | Publisher Full Text
Gonzalez-Juanatey C, Llorca J, Martin J, Gonzalez-Gay MA: Carotid intima-media thickness predicts the development of cardiovascular events in patients with rheumatoid arthritis.
Semin Arthritis Rheum 2009, 38:366-371. PubMed Abstract | Publisher Full Text
Gonzalez-Juanatey C, Llorca J, Miranda-Filloy JA, Amigo-Diaz E, Testa A, Garcia-Porrua C, Martin J, Gonzalez-Gay MA: Endothelial dysfunction in psoriatic arthritis patients without clinically evident cardiovascular disease or classic atherosclerosis risk factors.
Arthritis Rheum 2007, 57:287-293. PubMed Abstract | Publisher Full Text
Gonzalez-Gay MA, Gonzalez-Juanatey C, Vazquez-Rodriguez TR, Martin J, Llorca J: Endothelial dysfunction, carotid intima-media thickness, and accelerated atherosclerosis in rheumatoid arthritis.
Semin Arthritis Rheum 2008, 38:67-70. PubMed Abstract | Publisher Full Text
Gonzalez-Juanatey C, Llorca J, Garcia-Porrua C, Martin J, Gonzalez-Gay MA: Effect of anti-tumor necrosis factor α therapy on the progression of subclinical atherosclerosis in severe rheumatoid arthritis.
Arthritis Rheum 2006, 55:150-153. PubMed Abstract | Publisher Full Text
Gregersen PK, Silver J, Winchester RJ: The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis.
Arthritis Rheum 1987, 30:1205-1213. PubMed Abstract | Publisher Full Text
van der Woude D, Lie BA, Lundström E, Balsa A, Feitsma AL, Houwing-Duistermaat JJ, Verduijn W, Nordang GB, Alfredsson L, Klareskog L, Pascual-Salcedo D, Gonzalez-Gay MA, Lopez-Nevot MA, Valero F, Roep BO, Huizinga TW, Kvien TK, Martín J, Padyukov L, de Vries RR, Toes RE: Protection against anti-citrullinated protein antibody-positive rheumatoid arthritis is predominantly associated with HLA-DRB1*1301: a meta-analysis of HLA-DRB1 associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein.
Arthritis Rheum 2010, 62:1236-1245. PubMed Abstract | Publisher Full Text
Afzal AR, Kiechl S, Daryani YP, Weerasinghe A, Zhang Y, Reindl M, Mayr A, Weger S, Xu Q, Willeit J: Common CCR5-del32 frameshift mutation associated with serum levels of inflammatory markers and cardiovascular disease risk in the Bruneck population.
Stroke 2008, 39:1972-1978. PubMed Abstract | Publisher Full Text
Yan RT, Anderson TJ, Charbonneau F, Title L, Verma S, Lonn E: Relationship between carotid artery intima-media thickness and brachial artery flow-mediated dilation in middle-aged healthy men.
J Am Coll Cardiol 2005, 45:1980-1986. PubMed Abstract | Publisher Full Text
Gonzalez-Juanatey C, Llorca J, Gonzalez-Gay MA: Correlation between endothelial function and carotid atherosclerosis in rheumatoid arthritis patients with long-standing disease.
Arthritis Res Ther 2011, 13:R101. PubMed Abstract | BioMed Central Full Text
Quinones MP, Martinez HG, Jimenez F, Estrada CA, Dudley M, Willmon O, Kulkarni H, Reddick RL, Fernandes G, Kuziel WA, Ahuja SK, Ahuja SS: CC chemokine receptor 5 influences late-stage atherosclerosis.
Atherosclerosis 2007, 195:e92-e103. PubMed Abstract | Publisher Full Text
Braunersreuther V, Zernecke A, Arnaud C, Liehn EA, Steffens S, Shagdarsuren E, Bidzhekov K, Burger F, Pelli G, Luckow B, Mach F, Weber C: Ccr5 but not Ccr1 deficiency reduces development of diet-induced atherosclerosis in mice.
Arterioscler Thromb Vasc Biol 2007, 27:373-379. PubMed Abstract | Publisher Full Text
van Wanrooij EJ, Happé H, Hauer AD, de Vos P, Imanishi T, Fujiwara H, van Berkel TJ, Kuiper J: HIV entry inhibitor TAK-779 attenuates atherogenesis in low-density lipoprotein receptor-deficient mice.
Arterioscler Thromb Vasc Biol 2005, 25:2642-2647. PubMed Abstract | Publisher Full Text
Veillard NR, Kwak B, Pelli G, Mulhaupt F, James RW, Proudfoot AE, Mach F: Antagonism of RANTES receptors reduces atherosclerotic plaque formation in mice.
Circ Res 2004, 94:253-261. PubMed Abstract | Publisher Full Text


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Minn. officer whose heart stopped during fight goes back to work
By Mara H. Gottfried
ST. PAUL, Minn. — A St. Paul police officer whose heart stopped beating while tussling with a suspect on New Year's Day returned to work Monday.
David Mueller was initially in critical condition, but he quickly improved. He has been recuperating since, said Tom Walsh, a police spokesman.
Mueller, 47, had been a patrol officer in the city's Central District and was about a week away from being promoted to an acting sergeant in the department's auto theft unit. He stepped into the new position Monday, Walsh said.
What caused Mueller's heart to stop hasn't been determined, Walsh said.
Police said Charles Nackerud, 26, took a taxi from Hudson, Wis., to his home on St. Paul's West Side on Jan. 1 but didn't have enough money to pay the fare, so the driver called police.
Nackerud allegedly was combative and struggled with Mueller, who fell, hit his head, got up and then collapsed seconds later, police said.
Police arrested Nackerud on suspicion of assaulting a peace officer. The Ramsey County attorney's office declined to file a felony charge against Nackerud, and the city attorney's office is reviewing the case for lesser charges.
There was a rush to judgment of Nackerud, said Brian Karalus, the man's attorney.
"They don't even know what happened to him (Mueller) and everyone's making it sound like he's some guy who tried to kill a cop, when in fact he didn't have anything to do with him getting hurt at all," Karalus said.
Nackerud had pleaded guilty in December to driving while impaired and was slated to begin serving 30 days at the county workhouse on Jan. 8.
After his Jan. 1 arrest, Nackerud admitted he had consumed alcohol, a violation of his probation, and Ramsey County District Judge Salvador Rosas ordered Nackerud to serve an additional 60 days.
Nackerud was released from the workhouse on Feb. 4. After a Pioneer Press reporter inquired with Rosas' office Monday about the apparent discrepancy between the sentence and time Nackerud served, a law clerk discovered a clerical error had been made and Nackerud had been released early.
Someone entered Nackerud's sentence into a computer as a total of 60 days, instead of 60 additional days, said Rosas' clerk, David Haddick. A warrant was issued for Nackerud's arrest Monday, he said.
Inmates can be released from custody for good behavior after they serve two-thirds of their time.
Copyright 2007 Pioneer Press
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Mr. LaBeouf Shows Off His Stuff
Well hello there shirtless Shia! We thought he was just the future of Manjoyment, but we have to admit that these shots of Shia frolicking around in the sand are pretty hot. Clearly all the working out for Indiana Jones is paying off big time - who knew he was hiding those abs underneath his cheeky t-shirts? And the hair - love the non-gelled up, slicked back version! Shia should go more natural all the time. Basically, these photos are more than making our day, but what do you think? Is Shia ready to play Varsity for team Manjoyment or is he still just JV?
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Resolution: standard / high
Figure 3.
Establishment of IL-17-producing Th17 cells from uveitis patients with Behçet's disease. (A) Purified CD4+ T cells from a Behçet's disease (BD) patient or a sarcoidosis (SAR) patient (black bars) with active uveitis or a healthy donor (HD, open bars) in the presence of anti-CD3/CD28 antibodies, anti-IFN-γ antibody, anti-IL-4 antibody, rIL-1β, rIL-6, rIL-23, and rTNF-α. For ELISA analysis, supernatants of polarized Th17 cell lines or control CD4+ T cell lines in the presence of only anti-CD3/CD28 antibodies were harvested. The graph indicates the amount of IL-17 determined by ELISA (pg/ml). (B) For flow cytometric analysis, harvested Th17 cell lines from BD or HD were stained with anti-IL-17 abs and anti-CD4 Abs after permeabilization. The numbers in the histograms indicate the percentages of cells that were double-positive for IL-17/CD4. Abs, antibodies.
Sugita et al. Arthritis Research & Therapy 2012 14:R99 doi:10.1186/ar3824


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500 Nations: An Illustrated History of North American Indians
Knopf, 1994 - History - 468 pages
This is the stirring, crowded, epic story - laden with courageous deeds and dreams fulfilled and betrayed - of the hundreds of Indian nations that have inhabited our continent for more than 15,000 years and their centuries-long struggle with the Europeans who arrived in ever-increasing hordes after 1492. Here is American history from the Native American point of view - a long saga of friendship, treachery, war, and ultimately the loss of homeland that began when Columbus disembarked at Hispaniola among the Arawaks, and came to a climax when the last groups of Sioux moved onto a reservation following the battle of Wounded Knee in 1890. 500 Nations is a story of leaders, customs, political systems, and ways of life - of men and women whom we meet through their own words, and others whose achievements have been resurrected from memory, memoir, and ancient documents.
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Review: 500 Nations: An Illustrated History of North American IndiansUser Review - Fredrick Danysh - Goodreads
Here is a collection of information about many of the Native American nations and confederations of theAmericas. It is a handy reference tool to get a scope of Native American relationships and ways of life. Read full review
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If every teacher was this cool, I may have stayed in school, forever! Just in case you have browsers issues we have included all of the 'Stoned Professor' videos individually too. This is 'one of those things' you just shouldn't miss. An intelligent history lecture from a guy who is high! Stoned Professor Part 1 […]
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Harvard Economist Jeffrey Miron on Marijuana Legalization and Ending the Drug War
May 14, 2010
Video of Harvard Economist Jeffrey Miron on the reasoning for Marijuana Legalization and Ending the American Drug War, a statistical factorial example by technical deconstruction.
Prohibition Postcard
May 14, 2010
Ah… the good old days of prohibition… National Cannagraphic Magazine Tagged: culture history photo postcard prohibition
Shinto Cannabis Prayer of Amaterasu Omikami
May 14, 2010
Purity and fertility are paramount Shinto concepts, and cannabis is an essential symbol of both… the special prayer given for the founding Goddess of Japan is called "taima", which literally means "cannabis,"
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1. Main Entry 2. Pick Up-Large Items
The Fontbonne bookstore is to our west,
the Metrolink overpass is immediately east of us.
(Look for the black awnings)
Shop Monday thru Saturday
We're Open From 10:00am to 4:00pm
❉ Wednesday Evenings until 7:00pm
(Closed Sunday)
292 Hanley Ind. Court
Brentwood, MO 63144
(Only 1 mile from our previous location (on Big Bend)- we're on the southeast corner of Hanley Industrial Court and Strassner. Easy access from Hanley Rd., Brentwood Blvd. or Eager Rd. and plenty of parking.)
Furniture, antiques, lamps, mirrors, rugs, artwork, china, crystal– Baker, Thomasville, Henredon, Waterford, Noritake…
Our donors give us beautiful things, and we pass them on to you at rock bottom prices.
And the best part is, we're a not for profit organization so your purchases are tax-free!
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Subscribe to our newsletter, and every week we'll send you a sampling of new arrivals and let you know about sales and special offers.
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Our ever-changing inventory makes it possible for frequent shoppers to find those "just perfect" items.
(Items displayed here may no longer be available, but there's always something new!)
Shopping at MSP
The Miriam Switching Post accepts donations of gently used furniture and household items for re-sale. Because all items in the store are donated, we never know what the selection will be from one day to the next. Most items sell quickly and our selection changes frequently, so shop often to find the best merchandise.
Save Even More!
Check price tags for a date; if an item has been in the store 30 days, get a 10% discount. After 60 days, we'll discount it by 20%.
✔ Be sure to look for yellow tags to get the best deals; as much as 75% off original prices.
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We get new items in every day. Don't miss out on one of a kind items and sales – Get on our email list to receive notice of new arrivals, sales and seasonal specials. Stay in the loop –
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Whether it's for a special occasion, you need to say 'thank you' or you're just feeling generous; Miriam Switching Post Gift Certificates are the perfect treat. Available in any amount…
✔ Purchase them in the shop or by phone.
Proceeds from sales support Miriam–the Learning Disability Experts programs: The Miriam School and The Miriam Learning Center (located in Webster Groves).Your donations are greatly appreciated - and tax deductible.
✻ Find out more about the Miriam School and how your purchases help support our mission…


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Board Members
Patrischia Warmington – Chair
Patrischia Warmington has an arts background spanning 23 years, formed in youth arts and arts administration. She was an early member of the Black Mime Theatre Company and went on to write and direct touring plays for the Albany Empire Basement Youth Arts Theatre and comedy pieces.
Her post as the first Black Arts Development Officer for the Greenwich Festival in the early 90s stimulated her interest in African and Caribbean art forms and she has worked in this field in various management and development roles.
She studied for her MSc Grantmaking, Philanthropy and Social Investment at Cass Business School, and also holds a Prince2 qualification in Project Management.
Tony Corbin – Vice Chair
Anthony Corbin is a former lecturer at Lewisham College where he taught English, Access Courses and Media studies. One of the longest standing board members of IRIE! Tony's interests are Black History, Drama, Writing & Production; he is also a curator for exhibitions on the history of black people as well as equalities officer for UCU, the lecturers' union.
Trevor Mbatha – Treasurer
Trevor Mbatha has worked with IRIE! since its inception as a board member and an advisor. He has worked and been involved in the arts for over 29 years as a theatre production manager, arts officer, arts and cultural consultant for the Government, film and video documentary producer, and has been a member of various arts advisory boards e.g. London Arts dance adviser.
In the last ten years he has worked in the community and social regeneration sector primarily with housing associations. He is currently the Chief Executive of a community regeneration company which is based in the London Borough of Islington.
Lin Benjamin
Lin Benjamin is a B.A. in Social Science and a History graduate. She is also a certified Prince2 project manager, and an associate member of the Association for Project Management. For the last 7 years Lin has worked primarily within the voluntary sector, principally within the Community and youth sector, with a keen focus on the development of education /training/employment opportunities for communities. In her spare time Lin serves on a panel for the London borough of Hammersmith and Fulham Youth Offending Service. Her interests include literature, the Arts and participating in range of physical pursuits including distance running.
Deborah Rose
Deborah's Board membership has included, Derby City Challenge, Derby Consortium, East Midlands Arts Consortium, and Primary Employment, Education and Training Board (PEPT) (Chair).
Deborah's lifelong interest in the relationship between the mind and body, streamed from her own interests in Dance. This guided her to formally study the 'spirit' and its flow through a person, into the Arts.
Deborah has facilitated hundreds of undergraduate and postgraduate students in Higher Education. In her professional academic career at the Derbyshire Business School, University of Derby.
Wayne Thompson
A child of the Windrush Generation, in 1979 Wayne Thompson became the first Black person born in Great Britain to qualify as a solicitor. Trained by West End law firms three years after qualifying he also became the first Black Lawyer to establish his own law firm the in West End, which he then ran for 17 years.
Practicing as Wayne Thompson & Co from 9 Wimpole Street, London W1, the firm specialised in Community Care Law, Corporate and Commercial Property Law, particularly licensed/entertainment premises and Music and Entertainment Law. The firm set up a specialist youth culture unit called Youth Law.
Since 2006, Wayne has been engaged in full time doctoral research in theology. He is a DJ and an avid collector of vinyl records. Using Stanton USB key-lock turntables to bring older material up to current club beat speeds, the vinyl collection is able to deliver over eighty thousand titles.


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- 7/25/13
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User Statshot
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Level 2 Blank Slate
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Contact Info / Websites
Recent Game Medals
Bound to the Earth 25 Points Oh my goodNess! Medal Stats.
Rank RBH 50 Points You Won! Medal Stats.
Rank RPE 50 Points You Won! Medal Stats.
The Last Fantasy 25 Points Should've kept you Locke-d up Medal Stats.
Rank PBT 50 Points You Won! Medal Stats.
You Win! 10 Points Good job! Medal Stats.
Kredit 2 Team 10 Points Credit where credit is due Medal Stats.
Rank GAPI 50 Points You Won! Medal Stats.
Barnyard Blitz 5 Points It sure is animaly in here Medal Stats.
Act 1 5 Points Complete Act 1 to any standard. Medal Stats.
Total Medals Earned: 199 (From 1 different game.)


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Over the years, I've hung out with PALGN executive editor Jeremy Jastrzab a number of times. We even wound up in Paris one year for an Ubisoft do, totally enamoured with the legginess of a local burlesque show. He's a good guy and loves his gaming, which is why it's such a shame to see him and his editorial team leaving PALGN for good. So what happened? In quite a straightforward statement, Jez outlined the reasons why PALGN's staff will no longer be a part of the site as of February 10th:
Read full article by Toby McCasker


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SUMMIT's FF67FR is a commercially approved all-refrigerator sized for tight 24 inch spaces, with full features and a deluxe interior.
Automatic defrost saves on time and maintenance, while SUMMIT's unique design simplifies clean-up. We use a ''hidden'' evaporator set behind the rear wall to create a seamless interior. This allows you to wipe down the back without having to get between crevices or touch any machinery. It also maximizes interior space, giving the FF67FR one of the widest and deepest shelves in the industry.
The freestanding FF67FR is under 24 inches wide to fit in tight kitchens. The white exterior includes a two-piece stainless steel door frame that accepts custom panels, allowing users to match the refrigerator to other appliances and cabinetry. A stainless steel handle is included.
Inside, the FF67FR is fully featured for convenient storage. Adjustable shelves, door racks, and a crisper let you organize contents as you need. Interior lighting, an adjustable thermostat and reversible door are standard.
User friendly and energy efficient, the FF67 line includes a variety of models to fit commercial, household, and medical needs. For matching freezers, see SUMMIT's extensive line of FS627 all-freezers.


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Key West, Florida Attractions
Surrounded by the turquoise blue waters of the Gulf of Mexico, Key West is a beautiful island destination with a relaxed atmosphere, and tropical scenery with rich history. Explore Key West's historic homes, peaceful beaches, and iconic attractions - from the Hemingway House to Mallory Square that is famous for its Sunset Celebration. Stroll down Duval Street and enjoy local cuisine, shopping and exciting nightlife. If you are looking for some adventure head out to the Key West shore to enjoy scuba diving, snorkeling and fishing. If you love food, indulge in Key West's fresh seafood and culinary delights like key lime pie. Key West is also known for its major festivals like Fantasy Fest, Goombay, Strawberry, and Key West "Bight" Before Christmas.
The Key West Butterfly & Nature Conservatory, The Key West Aquarium, Tennessee Williams Exhibit, The Key West Lighthouse Museum, Ripley's Believe It Or Not! and the Key West Art & Historical Society are all great starts to your Key West Visit!


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New-look Good Machine continues to focus on Almodovars' El Deseo
Good Machine International (GMI), newly renamed Focus International, will handle worldwide sales on the forthcoming My Life Without Me, produced by the Almodovar brothers' Madrid-based El Deseo.
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External Web sites
- The Official Site of Amherst College, Massachusetts FAQ, directions, and photos.
Britannica Web sites
Articles from Britannica encyclopedias for elementary and high school students.
- Amherst College - Student Encyclopedia (Ages 11 and up)
Amherst College is a private undergraduate institution of higher education located in Amherst, Massachusetts, about 90 miles (145 kilometers) from Boston. Ranked among the top liberal arts colleges in the United States, it attracts students from across the country and several foreign nations. Total enrollment exceeds 1,500. Founded in 1821 as a men's college, Amherst first accepted women as transfer students in 1975 and as freshmen in 1976. The campus features an art museum, a natural history museum, a wildlife sanctuary, and a planetarium. Most buildings are 19th-century red brick. The college also administers the Folger Shakespeare Library in Washington, D.C., which was named for Amherst alumnus Henry Clay Folger.


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Once there was a Princess who from birth had been raised with all the necessary graces with which to attract an exceptional match. She had been born with beauty, with flaxen hair and eyes as blue as the sea, but her ability to dance, speak three languages and play the harp had been taught by the best tutors in the land. Her parents spared no expense to prepare their daughter. Not only did she have the best tutors, but she also wore exquisite gowns and bathed in the most luxurious essential oils. She was precious and she would save the kingdom from conflict and strife.
Princess Elena reached her 18th birthday still unbetrothed. She had been kept in the Palace's private quarters, away from the public gaze, awaiting the opportunity for the perfect political match. A pampered Princess such as this was surrounded by servants, the tutors being the most respected and best paid. Then there was the lady in waiting (a distant cousin), the seamstresses, the handmaidens who dressed and undressed her and the lowly chamber maids who kept her quarters.
The body guards were outside this hierarchy; they followed the orders of the King and swore loyalty and obedience to him alone. One body guard in particular was highly regarded and had been protecting the Princess for five long years now. He had watched her turn from spoiled child to elegant woman. At least he had seen her change physically, emotionally she had far to go. Emotionally she was still a child in many ways; moody, often petulant, always an open book. Physically, she had already reached mature perfection. She had become a dangerous distraction.
The body guard was a proud professional. He had come from a long line of soldiers and secret agents. He had fought in battle himself and had been wounded seriously enough to require a less strenuous posting. But even though he was a professional he could not help watching her for reasons other than protection. He would watch her sitting in her chair sewing, and his eyes would be fixed on the outline of her luscious breasts under the silky bodice of her gown. Occasionally he would catch a glimpse of a slender ankle as she changed position. He would watch her glide down a corridor and be transfixed by the gentle sway of her bottom beneath the silvery folds of her skirts. He would gaze on her tiny waist and the milky nape of her neck when her hair was up. He would hear her lilting voice in another room and long to have her in his view. Before long his dreams were invaded with disloyal visions of naked royal flesh spread out for his guilty pleasure. He was in a constant agony of longing that he could never hope to satisfy, and did not want to satisfy because that would mean committing close to treason.
What he did not know was the Princess had recently noticed him too. For years, he had been a constant background presence that she took for granted. He had arrived when she was thirteen and too young to regard the servants as anything other than instruments for her comfort and safety. She had spent her time with her tutors, most humourless middle aged men, the only young one being short and sickly with a weak chin. The bodyguards had been a constant but unobtrusive presence, no more interesting than the wallpaper or the curtains. But over the years her perspective had changed. She had always been thoroughly bored with the tutors and now refused to see them, insisting to her doting parents that she no longer needed their services. Instead she drew company from the gossiping handmaidens, all of whom found the bodyguards far more interesting than the curtains. They would sneak surreptitious looks at these silent untouchable young men and when away from the royal chambers would indulge in giggling and sighing over their handsome objects of affection. It was no atmosphere for a virginal Princess to be raised but her naive father had faith in his guards sworn loyalty.
The Princess had particularly noticed this one body guard who had been watching over her for five years now. He was tall, as they all were, and filled his black uniform with what she imagined to be rippling muscles such as she had seen on white marble statues. His head was closely shaved as was the custom, but what made him stand out was his face. His eyes were dark brown and rimmed with long black lashes. A scar cut through one eyebrow. His nose was slightly large but elegantly shaped. His chin wore a permanent shadow as if he found it impossible to hold back his stubble. His lips were full and she imagined his teeth to be white although she never saw him smile. When she was busily occupied with something such as embroidery she would try to secretly watch him at his post by the door, and sometimes she would think there was a certain look in his eyes, a heaviness, a heat. Lately she had begun to sit in a certain way, move her hips more rhythmically, let her gown cling to her curves, in the hope that he was watching. It excited her to think that he might be aware of her. It made her insides feel hot and molten. She lay in bed at night wanting to touch herself but not daring to. She imagined what his strong hands would feel like if he touched her.
She became more daring. Sometimes she would brush past him, letting her skirts skim his leather boots. Sometimes she would deliberately drop something so he would have to bend down and retrieve it for her and then she would let her fingers just touch his as she took it from him. Sometimes she would run her tongue along her top lip or suck the tip of her finger when she suspected he was watching.
Of course this Princess had led a sheltered, chaste life and these actions did not arise from knowledge. She knew nothing of what men and women did in the bed chamber. She was completely ignorant of matters carnal even though she had been raised to be a perfect mate. All she knew were the physical reactions she experienced when looking at this particular guard, or indeed when thinking of him. That, however, changed one day when she would make a shocking discovery in her father's library.
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Faces 90 years in prison
AFTER deliberating for a day and a half, a Superior Court of Guam jury yesterday found Kyle Indalecio Camacho guilty of kidnapping, robbery, terrorizing and two counts of special allegations of use of a weapon in the commission of a felony.
The 20-year-old convicted sex offender is facing 90 years of imprisonment after abducting a 19-year-old woman from the Micronesia Mall parking lot on Jan. 5.
Assistant Attorney General Gerald Henderson, who prosecuted the case, said he will seek the maximum sentence for Camacho.
The trial lasted four days, during which the victim and her sister testified about how Camacho brought handcuffs and a knife and forced himself into the car of the victim who had come from the Micronesia Mall movie theater.
The victim said Camacho drove off with her car, assaulted her and threatened to kill her while she was handcuffed.
The Guam Police Department executed a manhunt and eventually located the victim about 90 minutes later at the Marbo Cave parking lot.
"The apprehension and conviction of the defendant would not be possible without the bravery of the victim and hard work of the Guam Police Department, who quickly responded to the emergency call," Henderson said.
The Office of the Attorney General also thanked the victim for her continued courage in facing her abductor during the trial and for re-living her terrifying ordeal.
Attorney General Leonardo Rapadas also commended the victim's sister for alerting GPD immediately and for providing the information that led to the victim's rescue.
Camacho was on parole when he committed the abduction. He was on supervised release after serving time for a 2012 conviction for sexually molesting an 11-year-old female.
Judge Anita Sukola will sentence Camacho on Dec. 15 at 10 a.m.
The pre-sentencing investigation report deadline is Dec. 9.


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4 Hamilton Road
Germiston, Gauteng 1401
South Africa
Our Main service at Pajola is designing beautiful decor for each event from linen to draping, lights and flowers. We also can assist in finding a venue, catering, thank you gifts, entertainment, photographer, stationary, cakes and much.
Pajola Function Hire is a supplier of décor and catering equipment to the events industry. We pride ourselves in fast, efficient and friendly service, with a fresh look at the road ahead. Our staff will advise you in deciding on every element of your décor to ensure that the final look is just perfect for you.


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Canan Commons in downtown Muncie opened last year.
- Filed Under
This week, the David Owsley Museum of Art received a gift of an important two-faced helmet mask from southeastern Nigeria. With faces looking both forward and backward, it is tempting in the New Year to associate the mask with the Roman mythological figure of Janus who was the god of beginnings and transitions.
After all, the month of January was named in honor of Janus by the Romans. It might be a stretch to apply the association to this work of art from the Ekpo Society of western Africa, but it is tempting to make this wonderful gift from David Owsley an emblem of our memories of the last year and our ...


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Healthy Living: Local News
Your Health: How To Avoid Mosquito Bites
Story Updated: Jun 3, 2013
When the weather gets warm, the mosquitoes come out to feed on you.
While itching is usually the end reaction, mosquitoes can also spread the potentially serious West Nile virus as well Eastern Equine Encephalitis, which is rare in humans, but potentially life threatening.
Jeff Leiendecker of Jefferson County Public Health says the best defense is to eliminate free-standing water which is a breeding ground for mosquitoes.
"Common locations are clogged gutters, flower pots. A lot of the pots will have the catch tray at the bottom. That will catch the water, but it's a prime location for mosquitoes to breed," he said.
Leiendecker said it's important to dump out water which may have collected in gutters, pots or even children's toys.
Even with these precautions, contact with mosquitoes is inevitable.
Having your skin covered with lightweight clothing will help prevent a bite.
"Use a bug repellent with DEET, definitely follow the label on that and, if possible, apply it to clothing," said Leiendecker.
If you are bitten, avoid scratching by applying hydrocortisone cream or calamine lotion.
To prevent standing water from being a breeding ground for mosquitoes, a natural product called Mosquito Dunks can be used.
Tablets kill mosquito larvae but are non-toxic to wildlife and pets.


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General manager Ted Thompsons approach to free agency is a hot topic among Green Bay Packers fans.
My support for Thompsons approach in not engaging in bidding wars and overpaying for unrestricted free agents isnt shared by everyone in Packers Nation.
In another addition of Packers Talkback, I will publish the responses of several readers with varying opinions on Thompson and free agency, and as always, will offer my responses.
Keep those emails coming to firstname.lastname@example.com. I enjoy healthy debate and dont mind one bit if you adamantly disagree with my point of view.
Since I have received more emails than I can publish in one blog post, I will attempt to spread out your responses in the coming days. Thanks for reading and sharing your input.
Gary Rehfeldt
I dont think any Packer fan wants Ted Thompson to spend stupid money on anyone. What they want is a team made more competitive through free agency. When you essentially ignore free agency over a period of time your team is ignoring one tool that can be used to be more competitive. Especially when other teams are using that tool effectively.
The attendant problem is the poor results we have gotten from first-round draft picks over the past 5-6 years, and now it looks like you can almost add B.J. Raji (I still havent lost hope on BJ) to the following list: Justin Harrell, Derek Sherrod, Bryan Bulaga, Nick Perry and Datone Jones. How many games did those guys play total last year?? You add the first three together and you get ZERO.
Lets look back at what Ron Wolf did for Brett Favre. The Packers acquired Reggie White, Santana Dotson and Sean Jones in free agency. Along with Seth Joyner, Eugene Robinson and Keith Jackson to fill roles as well as plugging in Earl Dotson and others on the O-line. Ted needs to do the same thing for Aaron Rodgers and get some players to fill gaps, and make this team better.
I watched the replay of the 2010 Super Bowl a short while ago and noticed the defense no longer had Cullen Jenkins, Desmond Bishop, Nick Collins and Charles Woodson. Who have they replaced those players with? Burnett, MD Jennings, inside linebacker of the week, Datone Jones and Nick Perry?? I dont see an impact player among that list.
You are not always going to find a Reggie White or a Charles Woodson in free agency and I fully expect the Packers to miss on free agents just as ALL teams do. But it is the appearance that Ted isnt even trying to address Packer weaknesses through free agency, when it is unlikely they can ALL be addressed through the draft, that so irritates fans. He clearly has NEVER made a significant move via the trade route, which is another way to acquire players.
I have been a Packer fan for over half a century, suffered through the late 70s, all the 80s and the 90s pre-Holmgren. One thing I have come to observe is the rare talent of a player like Aaron Rodgers and I guess this year during the collar bone period we all found out just what a difference he makes. Ted is squandering some of Aarons best years and it will be a crime if he ends his career with one Super Bowl win, like Brett Favre. Ron Wolf said his biggest regret was the failure to surround Favre with more weapons; Teds regret should not be that he failed to give Aaron a COMPETENT defense. Thanks.
My response
There is no question Wolf was more aggressive in free agency, but the ultimate comparison with Thompson is that each has one Super Bowl victory on their resume. So was Wolfs way better than Thompsons? If the Packers win another Super Bowl in the coming years, then I would argue Thompsons path was more productive.
I dont disagree with you about Thompson needing to look at all options in upgrading his team, and I think he should be more active in free agency in three of the past four years he signed no one.
But what I dont condone is the wild spending that takes place in the early days of unrestricted free agency, and Thompson is wise to keep a low profile during this time.
I know the fans in Denver probably love John Elway right now because he opted to upgrade his defense by going on a spending spree for pass rusher DeMarcus Ware, cornerback Aqib Talib and safety T.J. Ward. I know this type of approach is exactly what the anti-Ted Thompson contingent would love the Packers to do, and how the Broncos fare next season could be a fascinating case study in how or how not to rebuild your defense.
I happen to think Elway, out of desperation, spent way too much for Ware, who is past his prime, and Talib, who is injury prone. I could be wrong on this, but I think these moves could blow up in Elways face and he will be stuck paying for his mistakes for years to come.
Thompson, meanwhile, re-signed Sam Shields and Mike Neal, to which some skeptical Packers fans say: How is this an upgrade by bringing back guys who played on a mediocre defense last season? My response to that is, Shields and Neal are young and improving players and could make major contributions in the coming years.
Ed Fusakio, Kings Mills, Ohio
Thank you for your beautiful defense of Ted Thompsons approach to building a team. You hit the nail on the head. I have been a Packer fan since 59. In the last 20 years there has been an increasingly more professional approach to building the Packer organization and the team. Coupled with the uniqueness of NE Wisconsin (lived in Appleton for 8 years in the 80s), uniqueness in the form of strong family values, down to earth people etc., it is a winning combination and one that high character football players seem to appreciate. Ted will find a good answer.
My response
It is Thompsons responsibility to do what is best for the Packers and I think his draft-and-develop approach is sound. I would like to see him supplement that approach by being a little more active in the secondary free-agent market a period after the initial spending sprees when decent players can be signed for reasonable prices.
As for bringing in high character players, that's all well and good, as long as they produce on the field. Sorry if that sounds harsh, but this is a bottom line business.
Tim, Minneapolis
People think that Green Bay's last 2 wins in Super Bowl games were because of Brett Favre and Aaron Rodgers. Of course, they were key BUT ...
It was two free agents that got them over the top -- both defensive players -- both unbelievable players. Reggie White and Charles Woodson!!
By adding White and Woodson, in my belief, not only made the defense better because of them, but also made Green Bay a place where higher quality players did not mind playing, like Sean Jones, Eugene Robinson, Desmond Howard, Andre Rison, and Keith Jackson.
In the NFL, there is a narrow period of opportunity to capture a Super Bowl, and Aaron Rodgers is not getting younger. Thompson needs to realize the opportunity lessens each year Rodgers (and Matthews) get older, and need to look for marquee free agents, preferably defensive players.
Green Bay was "really lucky" to get Rodgers in the draft, and the odds of getting the next good quarterback are slim to none! Thanks.
My response
I would contend the Packers window of opportunity to win a Super Bowl remains open as long as Aaron Rodgers performs at a high level, and barring major injuries, that will likely last for another 5-7 years, maybe more.
I dont think Thompson has to desperately throw money around in search of the missing defensive piece, as you suggest.
To win a Super Bowl, a team needs one or two difference makers players that make their teammates better and can single-handedly carry teams on their shoulders. I believe the Packers have those players in Rodgers and Clay Matthews, who were signed to long-term, lucrative deals last year. I dont think Thompson gets enough credit for his ability to keep those two superstars and still maintain a very manageable salary cap.
Now Thompson must surround those difference makers with solid players at as many positions as possible. I dont think they need a Reggie White-type player, or a Charles Woodson-in-his-prime type player, to get over the top.
If they can find a credible safety opposite Morgan Burnett, a decent inside linebacker, a younger impact pass rusher on the line and maybe they already have that lineman in Mike Daniels -- I happen to think the defense could be good enough to win a Super Bowl.
For every foolish dollar that Thompson doesnt spend in the early days of free agency, thats more money he has to re-sign excellent receivers Randall Cobb and Jordy Nelson, and that would be doing Rodgers a huge favor by keeping them in the fold.