text:
|In vitro cytotoxicity of novel platinum-based drugs and dichloroacetate against lung carcinoid cell lines.
MedLine Citation:
|PMID: 21239354 Owner: NLM Status: In-Data-Review
|Introduction Chemotherapy for advanced well-differentiated carcinoids is characterised by low response rates and short duration of responses. The present study aimed to assess the in vitro activity of novel platinum-based chemotherapeutic drugs in combination with dichloroacetate (DCA), a sensitiser to apoptosis, against lung carcinoid cell lines. Methods Three permanent cell lines (UMC-11, H727 and H835) were exposed to 14 different established cytotoxic drugs and the novel platinum-based compounds as satraplatin, JM118 and picoplatin in combination with DCA, and viability of the cells was measured using a tetrazoliumbased dye assay. Results With exception of the highly chemoresistant UMC- 11 line, the carcinoid cell lines (H727, H835) were sensitive to the majority of chemotherapeutics in vitro. Among the platinum-based drugs, carboplatin and oxaliplatin showed highest efficacy. H835 cells growing as multicellular spheroids were 2.7-8.7-fold more resistant to picoplatin, satraplatin and its metabolite compared to single cell suspensions. DCA (10 mM) inhibited the growth of UMC- 11 cells by 22% and sensitised these highly resistant cells to carboplatin, satraplatin and JM118 1.4-2.4-fold. Conclusion The highly resistant UMC-11 lung carcinoid cells are sensitive to carboplatin, oxaliplatin and the satraplatin metabolite JM118, but multicellular spheroidal growth, as observed in the H835 cell line and pulmonary tumourlets, seems to increase chemoresistance markedly. The activity of carboplatin and JM118 is significantly and specifically increased in combination with the apoptosis sensitiser DCA that promotes mitochondrial respiration over aerobic glycolysis. In summary, among the novel platinum drugs satraplatin has the potential for treatment of lung carcinoids and DCA potentiates the cytotoxicity of selected platinum drugs.
|W Fiebiger; U Olszewski; E Ulsperger; K Geissler; G Hamilton
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Publication Detail:
|Type: Journal Article
Journal Detail:
|Title: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico Volume: 13 ISSN: 1699-3055 ISO Abbreviation: Clin Transl Oncol Publication Date: 2011 Jan
Date Detail:
|Created Date: 2011-01-17 Completed Date: - Revised Date: -
Medline Journal Info:
|Nlm Unique ID: 101247119 Medline TA: Clin Transl Oncol Country: Spain
Other Details:
|Languages: eng Pagination: 43-9 Citation Subset: IM
|Department of Internal Medicine I, Division of Oncology, St. Poelten Hospital, St. Poelten, Austria.
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|MeSH Terms
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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text:
- 164Promote
iPhone Cases
In Sanityby Jacqueline Maldonado
Protect your iPhone with a one-piece, impact resistant, flexible plastic hard case featuring an extremely slim profile. Simply snap the case onto your iPhone for solid protection and direct access to all device features.
Love the colors and movement!!
As gorgeous as can be, Jacqueline! :)
Thank you Sharon, Andre & Laura! Your comments are so appreciated :)
beautiful. adore the colors
wonderful :)
Thanks Beverly & Carina :)
BEAUTIFUL as usual!
Love the colours!
Aw, thanks, Ben! That's sweet :) Thank you Kirsten!
Fabulous, Jacqueline. Fabulous.
Thank you, Geoffrey! Always appreciate your feedback :)
Pretty cool!
fascinating as always! just love the use of color
Thank you so much, Mo, Steven & Angela! Love to hear from you :)
Thank you Deepti & Meeralee! :)
It's a totally, beautiful surreal!
Thank you, Dan!
so fantastic!
Thank you, Voodoo!
Thank you so much, Renaissance!
That's cool. I think it's my favourite. You should do more ones like this.
Thank you so much Cameron! I actually am working on one right now, but sometimes a need a break from doing the same thing just to refresh my vision :) Thanks for the encouragement!
Thank you Lisa!
Really love all of these :)
Thank you Karin!
unique style, beautiful.
Gorgeous colours, very beautiful!!
wow super cool
Thank you so much Lauren!
Very beautiful
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subset: commoncrawl


text:
Justin Bieber Owns Up To Being Girl-Crazy And Ganja-Crazy, Sorta, On 'SNL'
In his first hosting gig on Saturday Night Live, Justin Bieber didn't address the Grammy snub that allowed him to be at New York's Rockefeller Center instead of L.A.'s Staples Center this weekend.
But he was plenty willing to make light of two other controversies that have dogged him in the last couple of months: that, post-Selena, he's supposedly turned into a pothead and a womanizer. His attitude, if we can take the evening's comedy sketches as any indication? Guilty as charged on having been ganja-crazy as well as girl-crazy, and sorry about the former, if not the latter.
The pot reference arrived during a "Miley Cyrus Show" sketch in which Bieber played a Miley super-fan guesting with Cyrus (Vanessa Bayer), now showing off her punky blonde mullet, as was dad Billy Ray (Jason Sudeikis). The Bieb got to refer to himself in the third person as a "douche" who "looks like a lesbian." "I heard he still has his baby teeth," said Bieber of Bieber, bewigged and squinting like a younger James Franco.
In a tumble of words that came out so quick, they might not even all have been on the cue cards, he added: "I also heard he got busted for smoking weed and he's really sorry about it and that people make mistakes and he's never gonna do it again."
That's one way to address the elephant in the smoke-filled room. (There were no sizzurp jokes, however.)
As for the gossip reports that Bieber has not been terribly shy around the ladies in the wake of his split with Selena Gomez, he didn't exactly do anything to downplay the idea of himself as a very sensually aware grown-up with a taped Valentine's Day come-on that had him rolling around on a luscious red bed and inviting gals to share some "sexy time" with him. The catch was that any sexual shenanigans would have to take place in the presence of his consigliere, an apparently mentally disabled dude named Taco (Bobby Moynihan, in heart pajamas).
Third wheels aside, the sketch established that willing women can still count on Bieber for champagne (illegal at his age, but what the hey), roses, satin sheets, naughty dice that turn up an instruction to "fondle butt," photos of the inside of his pants, and ultrasound gel that will have to suffice for massage oil. At this point, a lot of moms were regretting the decision to let the 10-year-olds stay up past 12.


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The Cotati-Rohnert Park School Board has rescinded its notice of intent to revoke the charter for Credo High School, ostensibly putting an end to months of acrimony between the fledgling school and its chartering school district.
"We intend to be as hands-off as the education code allows us," said Cotati-Rohnert Park Superintendent Robert Haley. "What we heard two weeks ago was they just need space to move from surviving to thriving. So we intend to give them that space."
The 5-0 vote Monday night ended a process begun in June when the board made formal the notice of violation, accusing Credo officials of financial and administrative mismanagement.
On Sept. 23, the board voted to officially proceed with the revocation but allowed backers of the Waldorf-inspired school extra time to address its debt and administrative issues.
But Credo backers did not need 45 days.
In the past week, Credo backers have paid $57,337 owed to the district and $4,743 to PG&E, the city of Rohnert Park and Rohnert Park Disposal.
School and district officials are making clear to Credo's creditors that the district is not liable for the school's ongoing financial obligations.
"We cleared up our short term debt with them," Credo board president Maria Martinez said. "I think that was a big piece of the puzzle."
"The fundraising really made a huge difference," she said. "The momentum from the parents is huge. We didn't have that before."
Credo also has progressed in the accreditation process, which is critical to getting college prepatory curriculum approved by the state university systems. A decision by the Western Association of Schools and Colleges on Credo's accreditation is expected in January, Martinez said.


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Young achiever: Kaitlyn Burkett
Age: 17
Neighborhood: Cranberry
School: Senior at Seneca Valley High School
Family: Parents Marnie and Troy Burkett; brother Nate, 15.
Noteworthy: For her senior project on safe driving, Kaitlyn secured a $2,150 grant through the FOCUS Project through Children's Hospital of UPMC and the Allstate Foundation for Seneca Valley's Students Against Drunk Driving organization. The grant will pay for two projects SADD will host before prom, including a driving safety presentation and creating a mock crash.
Hobbies/activities: Member of the Seneca Valley swim team and the school's National Honor Society.
Quote: "Motor vehicle accidents are the number one cause of death and disability for teenagers. It's a very important issue to address, and I'm glad I had the opportunity to increase awareness in my school and the community. Hopefully, it will be a safer environment coming out of it."
— Bill Vidonic
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text:
|list price:
|$23.99Nov 24, 2015
|Dec 01, 12am EST
|Get price drop email alerts
Released yesterday, Darksiders II: Deathinitive Edition includes ALL the possible DLCs, plus a graphics update too. 20% off after instant savings.
|list price:
|total savings:
|coupon code:
|for $1.99 off
|Green Man Gaming
|$18.00 w/ CouponJul 31, 2015
|Dec 01, 12pm EST
|Get price drop email alerts
Where do you paste the code at GameFly website?
During checkout, when you're about to put in billing info. Scroll down to middle of page and look for "Apply Gamefly Coupons" and put the code in there. You should see the 20% off.
Darksiders 2 is at 6$ on humblebundle weekly + much more included cheers guys
Darksiders 2 Season Pass is only $5.43 at Gamefly. Includes in game items and extra download content to the original Darksiders 2 game. Gamersgate has next best at $6.80 but elsewhere $20.
|list price:
|total savings:
|coupon code:
|for $2.74 off
|Green Man Gaming
|$24.75 w/ Coupon
expiredNov 28
|Nov 28
|Get price drop email alerts
Best price we've seen on the Darksiders Franchise Pack since July of this year. Includes Darksiders, Darksiders 2, and all the numerous Darksiders 2 DLC packs.
Everything Darksiders packaged up for $12 today at GamersGate. Includes the original Darksiders, Darksiders II, and all Darksider II DLCs.
The $11.99 Flash Sale price in the Steam Summer sale looked tempting for the Darksiders Franchise pack... but GMG is killing it today with drop to $9 after coupon. Three bucks cheaper than the Steam Flash Sale price.
The entire Darksiders Franchise Pack down to the $9 mark today at Games Republic in their Action sale. Last time we saw it this cheap was back in March for a few days and before that you have to go to the PC Gaming Winter sales. Hot deal if you consider Darksiders II alone is $29.99 right now on Steam.
The Darksiders Franchise Pack has dropped to only $9 today at GMG after an impressive 80% instant discount + a 22% off stacking coupon code. Includes Darksiders, Darksiders II, and 14 DLCs.


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Governor-elect Mike Pence and wife Karen are introduced to the crowd at the Pence-Ellspermann Inaugural Ball Dinner and Dance at the JW Marriott Saturday January 12, 2013.
- Filed Under
Indiana's next governor, Mike Pence, surely looked extra spiffy at last night's inaugural ball.
His mom made sure of it.
Pence said his mother, Nancy Pence Fritsch, bought him a new tuxedo to wear. ...


text:
Global Citizen Diplomacy of 21st Century — one individual, one city at a time
Afula-Gilboa, Israel | Amalfi, Italy | Avignon, France | Freetown, Sierra Leone
Hue, Vietnam | León, Nicaragua | Tetlanohcan, Mexico
Looking forward to another festive Quatorze Juillet Fete at Union league, 1032 Chapel St New Haven, this evening from 5pm-7pm! Hope to see you there!
Views: 47
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text:
November 30, 2015
Parkersburg Police are looking for Tiffany Wheaton.
Wheaton is wanted for one count of uttering.
Police say she is also wanted for two charges of petit larceny and one county of shoplifting.
If you know where Wheaton could be you are asked to call the Parkersburg Police Dept.at 304-424-8444 or parkersburgpolice.com
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text:
NCI Drug Dictionary
The NCI Drug Dictionary contains technical definitions and synonyms for drugs/agents used to treat patients with cancer or conditions related to cancer. Each drug entry includes links to check for clinical trials listed in NCI's List of Cancer Clinical Trials.
The search textbox has an autosuggest feature. When you enter three or more characters, a list of up to 10 suggestions will popup under the textbox. Use the arrow keys to move through the suggestions. To select a suggestion, hit the enter key. Using the escape key closes the listbox and puts you back at the textbox. The radio buttons allow you to toggle between having all search items start with or contain the text you entered in the search box.
- oxcarbazepine
A dibenzazepine carboxamide derivative with an anticonvulsant property. As a prodrug, oxcarbazepine is converted to its active metabolite, 10-monohydroxy. Although the mechanism of action has not been fully elucidated, electrophysiological studies indicate this agent blocks voltage-gated sodium channels, thereby stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing the propagation of synaptic impulses. Check for active clinical trials using this agent. (NCI Thesaurus)
US brand name: Trileptal Chemical structure: 10,11-dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide


text:
Essential Guide to Video Marketing: A Resource for Marketers
Do you want to use video for your business?
Are you looking for a resource to help you combine video with social media marketing?
Whether you're using video as an individual or as part of a team, these expert articles will help you live-stream, record, publish and market video to support your marketing goals.
Each of these articles will help you understand and master a specific part of using video for business.
5 Ways to Use Video to Improve Your Social Media Marketing
Are you thinking about adding videos to your social media mix?
Do you want to boost your awareness and increase engagement?
Social media networks provide a lot of video options.
From Google+ Hangouts to Twitter's Vine and Facebook's launch of Instagram Video, video is fast becoming an essential part of any business's online marketing strategy.
In this post, I'm going to show you how to incorporate video from 5 platforms into your social media strategy.
#1: Vine Video
For those who aren't into complex video production, Vine lets you create simple, six-second looping videos to share on Twitter and Facebook.
Viral Videos: How to Create and Promote Videos People Love
Do you struggle to create and promote videos?
Are you wondering how to make videos that go viral?
To learn about the creative process of coming up with video ideas and making them happen, I interview Mark Malkoff for this episode of the Social Media Marketing podcast.
More About This Show
The Social Media Marketing podcast is a show from Social Media Examiner.
It's designed to help busy marketers and business owners discover what works with social media marketing.
The show format is on-demand talk radio (also known as podcasting).
In this episode, I interview Mark Malkoff, a comedian and filmmaker.
Mark shares his love and passion for creating videos and several amazing stories behind his viral videos.
You'll learn about his process for creating video and how to get traction.
Share your feedback, read the show notes and get the links mentioned in this episode below!
Listen Now
Listen now: Play in new window | Download | Embed
Subscribe: iTunes | Android | RSSYou can also subscribe via iTunes, RSS, Stitcher or Blackberry.
5 Ways Your Old YouTube Videos Can Triple Their Visibility
Are you frustrated with your YouTube and video marketing efforts?
Most business owners test the "YouTube waters" by uploading a few videos, then walk away.
They return in a few weeks to notice each video has only a handful of views.
Is that your experience? If so, fret not! All is not lost…
In this article, I'm going to reveal to you five of the most powerful steps that you can put into action today to literally breathe life back into your existing videos, so your YouTube marketing efforts won't be in vain.
9 Ways to Use Social Media to Launch a Book
Wondering how to get people excited about your book? Do you want people actively sharing your book with their friends?
In this article I'll reveal some of the social media techniques I used to get thousands of people excited enough about my new book Launch: How to Quickly Propel Your Business Beyond the Competition that they shared it with friends and peers.
By the way, you don't need to have a book to benefit from these tactics.
Why Social Media for Books?
Back in the old days, book promotion heavily relied on the traditional press. I remember the challenge of promoting my first book (Writing White Papers) back in 2006. I had to work with journals and print magazines—and their long editorial cycles. I also needed to speak at physical events and perform many other time-consuming tasks.
14 Attention-Grabbing Tactics for Launching a New Business Blog
You've created a blog for your business. Now what? You're probably asking yourself, "How do people find out about my new blog?"
The simple answer is: You have to promote your blog and let people know it exists.
Optimizing your blog for search engines is critical, but just like any website, product, book or service you create, you have to promote the launch of a new blog.
There are a lot of ways to promote a new blog and I'm sharing 14 tactics to help you get the word out about your new baby. Heck, you could use these tactics for an established blog as well if you want a boost in traffic and subscribers.
But before you tell the world your blog exists, make sure you have completed these essential tasks first:


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Apparently sodomizing Greece wasn't enough for the IMF chief, who was just hauled off a plane in New York after an alleged sexual assault on a hotel maid.
UPDATE: just published some reflections on DSK here!
Sometimes, the irony of a situation is just so overwhelming that it's difficult to put into words just how insane the situation actually is. Tonight is one of those moments.
Dominique Strauss-Kahn (wiki), who as head of the International Monetary Fund specializes in sodomizing poor countries in financial distress, has apparently gotten just a wee bit too used to sticking his weener up places it don't belong (in particular working people).
Just a few hours ago, three officers of the New York port authority hauled Strauss-Kahn (who has been tipped as the leading contender for the so-called 'socialist' party in the 2012 French presidential elections) off his Paris-bound airplane, just 10 minutes prior to its scheduled departure. The officers subsequently arrested him on charges of sexual assault.
Strauss-Kahn is accused of walking up to a hotel maid naked and forcing her to have oral sex with him. It is the type of power trip one would associate either with a psychopath or with a deluded politician who has gotten so used to ordering people around that the last remaining semblance of respect for human dignity has evaporated altogether.
Clearly, respect for human dignity never ranked very high on the list of personal qualities an IMF chief is supposed to possess, but one would at least expect an economic hitman like DSK to limit his rapacious behavior to the financial markets. After all, raping Greek workers and starving Malawian children is still considered legal — sexually assaulting a hotel maid is clearly not.
Anyway, the New York Post broke the story tonight, but it has already been confirmed by the New York Times. While Le Monde, the center-left newspaper that has backed Strauss-Kahn's possible presidential candidacy, remains conspicuously silent, the left-wing Liberation at least did its journalistic duties.
Well, I don't really know what else to say about this overwhelmingly ironic situation, but at least it seems that the famous popular outcry – IMF GET OUT! – which has over the years resounded from the streets of Buenos Aires to Bangkok and from Ankara to Athens, just took on a whole new meaning in a New York hotel room.
Naughty, naughty IMF.


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Day of the Month Matters
Seasonality is tricky.
Certain seasonality biases clearly persist (ex. returns around the turn of the month), but the topic too often includes other events that are by their nature uncommon and subject to data mining (ex. returns around a given holiday).
I think the focus of this post, day-of-the-month seasonality, is the former: a real, persistent bias. The question is whether that bias is strong enough to actually influence your trading.
[logarithmically-scaled, growth of $1]
The graph above shows a simple walk-forward test, trading the S&P 500 from 1950 to present. By walking the test forward we ensure that the test only has visibility to the data available at that moment in history.
1. All months were fit to a standard 21 trading days. Months with less than 21 days were stretched, and those with more were compressed (1).
2. At the end of each month, I calculated the (geometric) average daily return for each of our 21 trading days over the previous 20 years (as of that point in time).
3. For the following month, I assumed we were long just those days that had (as of the previous month) performed better (red) or worse (grey) than the median trading day over the previous 20 years.
Results ignore transaction costs, slippage, return on cash, and dividends.
The test clearly shows that trading the days of the month that have been strong historically, consistently leads to stronger returns in the future. That's as true today as it was in 1950.
I've intentionally made this test as KISS as possible. The only parameter I've set is the 20 year lookback, and similar results are achieved using any lookback from ~10 years up.
Some of this observation's effectiveness is simply a result of the strategy picking up on the "turn of the month" (i.e. days near the beginning and end of the month) which have been bullish over the period tested.
But that doesn't explain all of the observation's effectiveness. Even days "inside" the month (ex. days 4 to 18) have been consistently stronger when part of the "best half" than when part of the "worst half".
. . . . .
As mentioned, I intentionally made this test as KISS as possible, and I would encourage readers to reproduce these results using more sophisticated measures of what days qualify as the best and worst parts of the month.
The more interesting question now is how this observation might influence actual trading.
First off, being one of the best days of the month (red) clearly doesn't by itself justify going long. There are still lots of ugly days in that red equity curve.
And being one of the worst days of the month (grey) doesn't justify going short. Returns have been middling, but not necessarily bearish.
So while I think this simple walk-forward clearly demonstrates that day-of-the-month seasonality exists, its only practical use is as an input into some other more predictive strategy. The observation isn't strong enough to stand on its own, but I think it could do a fine job helping to fine tune the trade.
Happy Trading,
(1) How I normalized months to 21 days: (a) number the trading days of the month from 1 to X (X being the last trading day of the month), (b) divide each trading day by X and multiply by 21, and (c) round the resulting value to the nearest integer.
. . . . .
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Filed under: Time-based, Trading Strategies | 23 Comments
23 Responses to "Day of the Month Matters"
Michael, that's interesting – I'm a bit of a fan of seasonality (in limited doses!). I don't say much here but am a great fan of your blog. Keeping it straighforward and approachable is quite a talent. Thanks for your continued efforts.
My interest in seasonality comes into play when timing deposits and withdrawals from my investment portfolios (along with some crude technical analysis). For instance, I make a monthly contribution to an SEP-IRA, so I want to do that on the best day of the month, which I think is 3-4 days before the end of the month.
I wonder how much of your day-of-month outperformance above comes from days within 5 days of the beginning and end of the month–outperformance I would be able to capture over time.
Thanks for a well-designed study!
Very very interesting…I can see many ways in which this sort of seasonality can be combined with other short-term indicators or special events.
One quick question: do you take into account holidays when normalizing the months to 21 business days?
Hi. I think this is an interesting post. One thing I wanted to ensure i get right from any further work and analysis is to build in the "normalisation" correctly to get to 21 days. Is it possible you can kindly post a spreadsheet with this just so I can replicate the formulae correctly?
Also, I presume as an example, that in 1982, you will have looked back to 1962-1981 and taken those years averages etc etc? ie the exercise, metrics are refreshed annually to take account of the latest seasonalilty and then applied to the forthcoming year
Good work
Michael, great stuff. Are the daily returns close to close or open to close. Thanks.
Hi Michael, thanks for a great blog!
I wonder if it is possible to give some good and bad monthly periods (less periods is better), to be in/out of the market.
Based on your responses above, if I wanted to limit trading to 2 periods, would a first period of say 5 days around TotM (eg. -2d, -1, TotM, +1, +2d) and a second period of say 5 days around mid-month (eg. -2d,-1, Mid, +1, +2d) be a good choice, irrespective of the month?
Regards, Wouter
Hello Michael. Did you do this walk-forward test with excel or vba excel or other program? It's not very simple the programming behind this test because first of all you have to transform the original time series in another with progressive day of month. Any programming suggestion?
Michael, what is the rationale of normalizing to 21 days?
An average trading month will have 21.74 days, so in terms of reducing rounding it seems that 22 is the better number, no?


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Renegades Claim Regional Win, Advance To World SeriesThursday, August 1, 2013
Members of Newtown's Cal Ripken 10U baseball team are feeling as if they are on top of the world. They are, after all, headed to the World Series. The Renegades captured the New England Regional Tournament championship with four consecutive wins, culminating with a come-from-behind 8-7 edging of Dedham, Mass in the championship game on July 27. The tourney was held at Cranston, RI's Ricci Field, July 20-27.
With the triumph, the Newtown sluggers are headed to the 10U Cal Ripken World Series in Ocala, Fla, August 10-17.


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Upon hearing it might snow, our one year old and 3 year old wanted to bring back the holiday elves. We set them next to the blooming bulbs Friday night. Saturday morning the were blanketed with snow. Happy Holidays once again!
April snow brings out the Elves
By: yamhillboysSubscribe Channel: Weather & Scenery Location: Hurley House, Five miles west of Yamill, 800 ft. elevation
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Hey lovies, I'm back!… and with some atypical Rosie Glow subject matter to boot. I know I preach wellness on this here blog, which you can bet includes exercise (daily exercise, no less), but in truth, I'm usually pretty wimpy in my efforts to sweat.
For the last several years, I've woken up almost every day at the crack of dawn, gleefully donned my kaleidoscopic rainbow octopus Asics:
…and skipped off to the gym like the pansy I am (LOVE pansies.) There, as I've said before, I usually miss the start of spin class/ body pump by a hair (damaged, pinkish DESERT hair :(), plus I really just want to do my own thing anyway; so I proceed to run/dance on the eliptical while watching AMTV (did you all know Justin Bieber was over 2 hours late to his last London show?! For shame!) and lip syncing all. over. the. place.
Every day.
Honestly, it's a joyful practice – but I should consider it meditation, at this point, more so than exercise… because after all these years, I could be on an eliptical machine for 2 hours and not feel a darn thing. I advocate checking in, and being gentle with yourself – but that's not an excuse to phone it in, yo! (For shame!) My routine has simply become too routine.
So last night, I took a live DJ spin class that kicked my wussy butt. And yes, I did say live DJ – the scene looked like this:
I go to spin classes all the time… at least two or three times a week. But THIS spin class made me feel like I was going to die… and I loved it. It made me realize that I haven't pushed myself to the point of panting, red-faced VICTORY in years – since days at camp spent running up and down a basketball court and eating these as fuel: since tae kwan do classes of yore whence young Rosie Glow was a pine-cracking TERROR.
I think not having been too intense about exercise in my twenties has been good for me, mentally. If you've been reading for a little while, you know I'm inclined towards extremes: with food, life goals, attitudes about people. An hour or so a day of designated zoning out while my legs are moving and my heart is calmly pumping ain't so bad… but I'm gearing myself up for a personal challenge, wherein I bust my own chops a la Shaun T. I'll be attending more bootcamp-style classes and hardcore twerkin' it… not every day, but a few times a week. I've thought about the aforementioned Shaun T.'s Insanity program and P90X DVDs, but let's be real… if I have 45 minutes to kill at home, I'm in my pajamas eating grapes and watching Project Runway – not doing burpees. As Tim Gunn says…
I'll keep you all updated on my exercise findings! I've also got some food as medicine experiments in the works… remember seed cycling? And… I just ordered big ol' bags of maca and spirulina powders. Wait, no one else is pumped about high-protein pulverized seaweed and primitive plants that taste like feet? Cool. More for me.
What do you all think about exercise intensity? What's your practice and are you satisfied with it? I'd love to know!


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Co-sponsored by the Career Development Office at Brandeis International Business School (IBS) and the Hiatt Career Center, the event will feature workshops and programs focused on teaching students important career skills, including how to market themselves and expand their professional networks.
The summit is expected to draw more than 400 Boston-area students and professionals from 25 Fortune 500 companies and other organizations, including Liberty Mutual, TJX Companies, PricewaterhouseCoopers and State Street Corporation. The full schedule is available on the ALPFA Boston website.
ALPFA has a long history of partnership with Brandeis, and over the years has worked closely with Brandeis' career offices to hold workshops, networking events, and recruitment fairs. At the 2012 ALPFA National Convention in Las Vegas, the university's chapter was recognized for its contributions and named the student chapter of the year for the Northeast Region.
"Brandeis has been and continues to be a leading ALPFA student chapter in Boston and nationally," said Radhames Nova, executive director for ALPFA Boston. "Our strong relationship with the university spans from undergraduate students, to the international school of business, to Hiatt and the Brandeis IBS career office, and to top university leaders like [Brandeis IBS] Dean Bruce Magid. This strong partnership is mutually beneficial to Brandeis students and the ALPFA community in Greater Boston."
Brandeis IBS Dean Bruce Magid, who will be making opening remarks at the event, underscored the importance of students taking advantage of these sorts of career opportunities.
"Active participation in training, career fairs, symposiums and conferences like this help students grow their skills and gain important contacts with potential employers here and around the world," said Magid, who worked extensively in Latin America during his career at Bank of America, and also served as senior adviser to the Minister of Planning in Venezuela.
"Organizations like ALPFA have a tremendous impact on students' professional development," said Joseph Du Pont, dean of the Hiatt Career Center. "ALPFA helps students travel off-campus to engage directly with professionals and employers, while also enabling student leaders to bridge the interests of students, schools, professionals, companies and communities alike."
Students from Brandeis can register free of charge for the summit directly via Hiatt and IBS' online registration page. Interested students can also join ALPFA at a discounted rate on their website.


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The Music of Sparky Davis / Petr Vronsky, Vit Micka, Karolina Rojahn
1 CD / Navona / 2013-01-29Works: Sparky Davis: And One Last Waltz, for orchestra; Symphony in B flat major; Adagio di molto misterioso, for orchestra; Fantasy Sonata for piano; Unspecified: Untitled CD-ROM Track
Performers: Rojahn, Karolina
Conductors: Micka, Vit; Vronsky, Petr
Ensemble: ; Moravian Philharmonic Orchestra
Composer Sparky Davis, who takes a "modern, not modernistic" approach to writing his music, expands the vocabulary of music to include non-traditional elements and adds...continue...
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Beach: Variations on Balkan Themes
1 CD / Centaur / 2009-09-03Works: Amy Beach: Variations on Balkan Themes for piano (or 2 pianos, or orchestra), Op. 60; Chanson d'amour, for voice & piano (with cello obbligato), Op. 21/1; Ecstasy, song for voice & piano with violin ...
Performers: Ananda-Owens, Kathryn; Atzinger, Christopher; Carter, David; Feldt, Alison; Valdivia, Hector
Conductors: Valdivia, Hector
Ensemble: Moravian Philharmonic Orchestra
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|Clinical Efficacy of the GnRH Agonist (Deslorelin) in Dogs Affected by Benign Prostatic Hyperplasia and Evaluation of Prostatic Blood Flow by Doppler Ultrasound.
MedLine Citation:
|PMID: 23320475 Owner: NLM Status: Publisher
|In six German Shepherds dogs, GnRH agonist implants (Deslorelin) were inserted subcutaneously one month after histological confirmation of benign prostatic hyperplasia (BPH). Prostatic volume (PV), characteristics of ejaculate, serum testosterone concentrations and Doppler parameters of prostatic and subcapsular arteries were detected at different time intervals, for 6 month. The prostatic volume showed a significantly reduction starting at day 37. The decrease in sperm concentration, motility and increase in morphological abnormal sperm were observed from day 22 to day 37, when it was no longer possible to obtain the ejaculate. The values of peak systolic velocity and end-diastolic velocity in prostatic and subcapsular arteries showed from day 11 a gradual decrease, significant at day 22 until day 37 and reaching the lowest values at day 52 until the end of observation. The power Doppler pixel intensity of both arteries showed a gradual decrease from day 5 until day 52. In particular, a significant decrease was observed for both arteries from day 11. Testosterone serum concentration decreased to undetectable levels by day 11 until the end of the observations. All these Doppler parameters and testosterone values were positively correlated with the prostatic volume. Furthermore, testosterone values were positively correlated with peak systolic velocity, end diastolic velocity and pixel numbers. The use of implants containing GnRH analogues, even in asymptomatic subjects, is effective for the control of BPH and the application of Doppler exam of prostatic blood flow represent an non-invasive tool for monitoring the response of medical treatment.
|A Polisca; R Orlandi; A Troisi; G Brecchia; M Zerani; C Boiti; R Zelli
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Publication Detail:
|Type: JOURNAL ARTICLE Date: 2013-1-16
Journal Detail:
|Title: Reproduction in domestic animals = Zuchthygiene Volume: - ISSN: 1439-0531 ISO Abbreviation: Reprod. Domest. Anim. Publication Date: 2013 Jan
Date Detail:
|Created Date: 2013-1-16 Completed Date: - Revised Date: -
Medline Journal Info:
|Nlm Unique ID: 9015668 Medline TA: Reprod Domest Anim Country: -
Other Details:
|Languages: ENG Pagination: - Citation Subset: -
Copyright Information:
|© 2013 Blackwell Verlag GmbH.
|Dipartimento di Patologia, Diagnostica e Clinica Veterinaria, Sezione di Ostetricia e Ginecologia, Facoltà di Medicina Veterinaria, Università degli Studi di Perugia, Perugia, Italy.
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|MeSH Terms
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An endocrinologist in Auburn, Dr. Shirwan Mirza diagnoses, treats, and manages endocrine disorders, or those affecting the body's secretion of hormones such as thyroid problems or diabetes.
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Obama's LEGAL immigration reform 2015.What does it mean? Listen to video discussions by Attorney Rajiv S. Khanna on Immigration.com YouTube Channel. Subscribe to Our YouTube channel to be notified when new updates are posted.
When should I apply to renew my RTD?
Discussion in 'Political Asylum in USA' started by algorithm, Apr 9, 2012.


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Mt. Etna (Sicily) spewing ash and lava in the fall of 2002.
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SANTA Barbara City College
Department: Computer Information Systems
Subject Area and Course Number: CIS 105
Course Title: Introduction to Operating Systems
Discipline: Computer Information Systems
Units: 4
Repeatability: None
Catalogue Course Description: Introduction to the administration of microcomputer operating systems, including the Windows Command Line and UNIX/LINUX. Provides occupational preparation for information systems professionals, such as PC support personnel, computer programmers, network/systems managers and related technical and operations-administration personnel.
Description for Schedule of Classes: Introduction to administration of microcomputer operating systems, including the Windows Command Line and UNIX/LINUX.
Lecture Hours per Week: 64-72 Total Semester Hours
Laboratory Hours per Week: None
Plus Hours: 32-36 Total Semester Hours
Prerequisite: None
Co-requisite: None
Skills Advisories: Eligibility for English 110 or English 110GB or English 110H
Course Advisories: CIS 101; may be taken concurrently
Limitation on Enrollment: None
Course Objectives: Upon completion of this course, the student will be able to:
1. Describe how multi-tasking operating systems differ from single-tasking systems.
2. Identify the additional problems imposed by a multi-user environment.
3. Specify how to set up different operating systems on personal computers.
4. Identify the fundamental commands needed for each operating system.
5. Compare and contrast operating systems and decide on the most appropriate one for any given environment.
6. Troubleshoot problems in each of the operating systems.
Course Content and Scope:
1. Microcomputer Systems: Hardware, Software and the Operating System
a. Categories of Computers
b. Computer Components
c. Microcomputer Hardware Components
d. Capacity Measurement and Secondary Storage Devices
e. Categories of Software
f. Overview of Networks
2. Operating System Concepts
a. What is an Operating System
b. Overview of Files and Disks
c. System Configuration
d. Booting the System
e. Operating Systems Techniques – Multi-tasking, Multi-user, Virtual Memory
3. Windows Command Line
a. Running the Command Line under Windows
b. Basic Command Line Commands
c. File System and File Management Commands
d. Pipes, Filters and Redirection
e. Batch Files and Parameters
4. Windows Family
a. History of Windows
b. Comparison of Windows Products
c. Installing Windows on Standalone Machines
d. Installing Windows on a Network
e. Operating Windows
f. Editing, Copying, and Moving in Windows
g. Managing Files
h. Using Object Linking and Embedding
i. Windows Shortcuts
j. Troubleshooting Windows
k. Examining and Modifying the Registry
5. Connectivity
a. Networks (LANs and WANs)
b. Setting Up a Network
c. Sharing Printers
d. Sharing Hard Drives and Folders
e. Mapping Drives
f. The Internet
g. Overview of TCP/IP
h. Ping and FTP
a. The History and Uses of UNIX/LINUX
b. Installing UNIX/LINUX on Standalone Machines
c. Installing UNIX/LINUX on a Network
d. Signing on the UNIX/LINUX System
e. Simple UNIX/LINUX Commands
f. Use of the Shell
g. Directories and Files
h. Commands and Standard Files
i. User to User Communications
j. Text Manipulation
k. UNIX/LINUX Editors
l. Programming the Shell
Methods of Instruction:
1. Lecture
2. Discussion
3. Media presentations
4. Student presentations and critiques of programs
5. Guest lectures
Required Assignments:
1. Reading assignments from textbooks and handouts.
2. Lab assignments setting up operating systems and exercising them.
3. Homework assignments including end-of-chapter questions from text to include objective and essay items.
4. Sample Assignment: Write a series of batch files to perform stated activities, such as taking action on user input.
Methods of Evaluation: Grading will be based upon written quizzes, homework assignments, computer-based assignments, and a comprehensive final exam containing objective and short essay items.
Appropriate Texts and Supplies:
Windows XP Command Line, Carolyn Z. Gillay and Bette A. Peat (Franklin, Beedle and Associates, 2002).
Guide to UNIX Using LINUX, Michael Palmer (Course Technology, 2008).
Student Learning Outcomes:
1 - OS Terms - Define technical terms used in operating system technology
2 - OS Features - Compare and contrast the features of different operating systems
3 - OS Commands - Choose appropriate operating system commands at the command line to perform different operating system functions
4 - Scripts - Write scripts to automate complex or repetitive processing tasks
5 - Utilities - Choose the appropriate utilities to resolve operating system performance and configuration problems
Approved Jan 2000
Revised 2/9/09
10/09 SLOs


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Green Festival Exhibitors
Omega Tax and Accounting, Inc. and DM Group Associates, Inc.
13640 Claire Blvd., Robbins, Illinois, United States, 60472 - View Map
Come visit Omega Tax & Accounting and DM Group Associates to learn about plans to make Robbins, Illinois the south suburb's first sustainable and walk able community. History is in the making and you don't want to miss this! Join us as we make a difference?


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On June 4 we traveled by train from Florence to Venice for a very quick visit. We did not stop for the American breakfast offered at the McDonalds in the train station. What does that sign say about Americans food choices?
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Last day in Firenze! We visited the Pitti Palace of the Medici. Ironically, the throne room also included Christ on His throne, quite a statement of affinity. We walked through more than 50 some rooms stuffed floor to ceiling with Rubens, Titians, Tintorettos, and painted ceilings.
Popular tags: Firenze, art, Venice, St. Francis, St. Clare
Today we visited the uffizi gallery. It was exhausting to see miles of renaissance and medieval art all compacted into one space. However, we enjoyed the Botticelli gallery and the Caravaggios. I am drawn to the dichotomies.
Popular tags: Uffizi Gallery, art
We (Holly and Karen) stayed an extra night in Rome meeting with former colleague, Sr. Jaculin Manders. We got a lesson on Roman public bus system from her.
Popular tags: Rome, Florence


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November 29, 2015
Two people are in custody in connection with a Dairy Queen burglary, caught on tape.
Richmond police charged Joshua Abner and Curtis Collins with burglary.
Police say the two are the men are seen robbing the restaurant earlier this month.
Both men wore masks to cover their faces.
Collins and Abner are now in the Madison County Detention Center.
Click Here to access the online Public Inspection File
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A Super-Easy Sun Hat DIY, Courtesy Of J.Crew
Not totally into those $4.99 straw hats you find in the drugstore next to the plastic lawn chairs? Make them a whole lot more manageable with J.Crew fashion director and head stylist Gayle's suggestion: "Trim down a wide straw hat for a raw-edged brim that's one of a kind." The end result is something slightly Huckleberry Finn, but in a Jane Birken sort of way (it helps to wear yours with delicate summer dresses instead of — say — tattered overalls). Genius!
Photo: Courtesy of J.Crew