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Content Marketing
Five good reasons to ignore Google
May 26th
I've been exploring ideas for creative new content forms and I've come to a realization. Google is holding us back.
Think about how much of what we create, and how we create it, is influenced by Google's rules (or what we know of them). Conforming to SEO best practices forces us into a very small creative box, and the more we we get creative and stray from that box, the less likely we will show up in Google's search results. There is a constant trade-off between form and practical search considerations.
When is it time to just ignore Google and go for it?
Here are some thoughts on when we can — and should — ignore Google.
1. When you're epic.
One of my favorite recent {grow} posts was a display of 10 soul-grabbing brands that are creating content so wonderful they simply don't need SEO.
In fact, I recently demonstrated that adhering to the rules of SEO can actually prevent you from going viral. Even in my own little world I can see that my least-optimized posts often do the best because by definition, they are something entirely original.
A favorite example is the Funny or Die site. It is so creative and endlessly entertaining. With videos titles like Tiny Detectives and The Landlord (one of the funniest videos ever) this site isn't ever going to need a keyword strategy!
If you're creating content so consistently compelling that you have become part of the conversation, you really can work outside the boundaries of Google, right?
2. When you're huge
You know who can ignore Google? Apple. Apple can ignore the Big G all day long. They're the most valuable brand on earth. If you want an iPhone, you're getting an iPhone and there is not going to be a search engine in the way.
But I'm a little guy. I still get a ton of organic traffic to my website. I have to play by Google's rules until I am as big as Apple. I am projecting this to occur sometime in 2016. More or less.
3. When there are better search engines for your product
You know what is awesome? Etsy. You can find some pretty cool crafts there. If you're in the business of selling hand-crafted leather keychains or carved stone garden ornaments, it makes sense to optimize your Etsy, right? I wouldn't even think of using Google. When I want to find a nearby restaurant in a new city I usually turn to Yelp. When I am looking for a particular book as a present I go to Amazon. And so on.
And by the way, Amazon is quietly rolling out a service where you can find local service providers like plumbers and landscapers. Apparently Amazon takes a small cut as a referral fee. Keep your eye on that new seach engine.
4. When you have paid subscribers
Have you seen some of the amazing creative treatments in online magazine versions? My favorite is Esquire. In the last edition, the cover of the online edition was a stylish movie … and that's not uncommon. The editors make their magazine come to life in so many amazing ways and Google be damned. Why? They don't need search. All they need is paid subscribers. Keep it cool, keep it exclusive, and keep it away from Google!
5. When it doesn't matter any more.
I have seen the future and it is ZIte-like. Zite is the best utility I have seen so far to actually "learn" what content I enjoy. It customizes an evolving delivery system based on what it is learning about me. The more I use it, the better it gets.
Five years ago when you or I did a search on Google for the best deal on an automobile or a review of a new car model, we would get similar results … probably the same results. But over time, Google has made its search results highly-tailored to your environment. Where are you? Who are you? Who are your friends? This has resulted in an ever-tightening bubble of personalized results. The results you would get today are almost certainly different from what I would get.
Zite is an even more extreme example of this as it actually pushes content to you and only you, constricting the scope of possible content that you see. Will that require different strategies? Perhaps we won't just be concerned with SEO. We might also need to consider Zite Engine Optimization? : )
So that was a little weird and rambling. My point is that how we get our information is probably fragmenting. This will present both challenges and opportunities as we struggle to conform to Google-topian rules of conduct or use new content forms to break free and stand out!
What do you think?
33 Inspiring B2B digital marketing case studies
May 21st
By Rob Petersen, {grow} Community Member
First, a few depressing facts:
- 86 percent of B2B companies say they are doing content marketing
- Just 38 percent say it is effective
- 21 perecnt are able to track a return on investment (ROI) (source: Content Marketing Institute)
Benefits from marketing and attribution of results always seem harder for B2B companies than B2C. Maybe it's because the buying cycle takes longer, more people are involved in purchase decisions and sales are made for rational, not emotional, reasons.
Is it harder or are we not looking hard enough?
If you need convincing, here are 32 B2B digital marketing case studies that prove the potental ROI. In this post, we wil feature case studies in the areas of content marketing, social media marketingm social CRM, social selling, LinkedIn marketing, and webinars.
Here we go:
- ADP: Developed a content marketing campaign to connect and engage with their target audience on a ADP solution using white papers and a diagnostic assessment tool. The campaign generated over $1 million in new sales opportunities with several deals closed within the first 3 months of launch.
- CROWE HORWATH: the public accounting firm used 48 pieces of content in 4 different topic areas, this campaign targeted C-level prospects in financial institutions with $1 billion or more in assets across the buying cycle. Content tactics included: executive briefs, case studies, infographics, checklists, Q and A, and Brainshark video. 778 contacts were engaged with a 70% open rate (vs. 10%), 2 engagement worth $250k in revenue.
- DEMANDBASE: A B2B marketing cloud, helped B2B marketers make the right content technology investment by using a white paper, infographic, webinar, Slideshare and a live presentation to spotlight tools that can maximize the power of content. The results of the campaign generated 1,700 leads, 125 webinar participants, 5,000 views on Slideshare and $1 million in new business.
- FISHER TANK: Makes giant, above-ground welded steel tanks. With clients in the fuel industries, waste water, pulp & paper and other industrial and municipal areas, projects tend to be big (multi-million dollar) and take a long time to sell (12 months and longer). For more than 60 years, the company has made its sales primarily through cold calling and referrals from existing clients. So it took some moxy to launch a content marketing strategy online. The plan including sprucing up the website, integrating a blog and social sharing, and offering some valuable content by free download. The campaign increased web traffic by 119%, traffic from social media by 4800%, lead conversions by 3900%, quote requests by 500% and new qualified sales opportunities by $3.4 million.
- LOGICALL: A company that focuses on inbound and outbound customer management solutions, uses content assets such as emails, microsite and ebook, Logicalis developed a thought leadership effort that supported sales teams by enabling custom messaging based on the prospects interaction with the campaign. With a target audience of about 2,000, nearly $8 million in new pipeline business was closed.
- OPENTEXT: A software solution for enterprise information management, created a personalized new customer onboarding site offering a variety of assets (white papers, checklists, product pages, ebooks, case studies) and content to welcome new clients and provide upsell, cross-sell opportunities. The campaign also included a two phase nurturing program. 1,700 new contacts were identified along with 31 new opportunities worth $1.8 million.
- OPTUM: A health services business, created an integrated marketing campaign to support the launch of a new solution, support sales and build thought leadership. The content marketing mix included: advertorials, display ads, email, direct mail and a campaign website. The successful campaign earned a 23.5 lead to conversion rate, 475% increase in website traffic, 2,500+ resource downloads, 28% increase in YoY blog followers and $52 million in contract value of new business with less than $ 1,000,000 invested.
- RS COMPONENTS: The electronic product distribution company created a specific social hub, spanning four different languages, having the purpose of being a collaboration and engagement hub for Electronic Design Engineering. One of the centrepieces of the site is the free tool store, which includes a free design tool that's been downloaded more than 60,000 times and the site itself gathered more than 45,000 members within its first 12-month period.
- SAP: The global strategy was aimed at enabling cross-cultural information to be efficiently shared around the company. SAP Latin AmericaOne year after implementing this strategy SAP Latin America had more than 100,000 fans and followers (an increase of 900%) and achieved a 17% interaction rate across the region, while a campaign featuring a social app targeting specific buying centers drove more than 12,000 visitors and a 15% engagement rate. has four Facebook pages, four Twitter feeds and two LinkedIn accounts. These profiles are split out by language (e.g. Portuguese and Spanish) rather than country and aim at achieving a split of 20% promotion material vs. 80% of interesting, engaging content for its community.
- XEROX: Created a targeted "Get Optimistic" campaign to connect with 30 top accounts and partnered with Forbes to create a magazine that offered relevant business tips. 70% of targeted companies interacted with the microsite, readership increased 300-400% over previous email campaigns, added 20,000 new contacts, generated 1,000+ scheduled appointments, and get this: yielded $1.3 BILLION in pipeline revenue.
- CISCO: Established a social media listening center. It listens to more than 5000 social mentions a day on Facebook, Twitter, and other social channels. Cisco has been able to control outside agency fees, avoid other customer and partner interaction costs, increase team productivity, and identify new sales opportunities. The social media listening center has had an ROI of +281% in 5 months to generate an annual benefits of $1,596,292.
- MAERSK: Danish shipping company Maersk first began using social back in 2011 to raise brand awareness, gain insight into the market, increase employee satisfaction and get closer to its customers, It focuses on the stories that emerge from within the business, such as how it is helping fuel a boom in the sale of Kenyan avocados and where its staff come from. Its presence on each network is tailored to that platform, so for example on LinkedIn it promotes job vacancies and publishes articles about the work culture within the business, while on Instagram it encourages followers to post photos of its ships using the hashtag #Maersk. Maersk now has more than 1.5m Facebook fans (of which around 15% are customers) and 12,000 Twitter followers, as well as active accounts on Instagram, Tumblr, YouTube and Google+.
- DELL sought to go where its customers are — on social media — by offering technical support, responding to customer concerns and building business digitally. The company launched @DellCares, a program that uses social media platforms and online communities to address customer questions and reply directly to customers through tweets and other response methods. According to Amy Marquez Bivin, Social Media Outreach Manager, 98 percent of customer issues responded to through @DellCares are resolved without customers needing to work with an agent and 85 percent of social-media-assisted customers with negative initial opinions of Dell reported a positive opinion following the support experience. The program is also generating an average of $265,000 in additional weekly revenue.
- SHIPSERV: It's difficult to imagine the maritime industry getting to grips with social media, but Shipserv one of the leading industry marketplaces, proves that in can be done very successfully. As part of a wider marketing strategy and customer engagement strategy, various social approaches were taken, resulting in greater site traffic, alongside increased brand awareness and lead opportunities. From an initial $30,000 social media marketing investment, it's estimated the overall results achieved would have cost more than $150,000 through traditional media.
- ALLINA HEALTH: Used CRM to manage its data warehouse. It's identified benefits that include reduced patient length of stay, reduced admissions, and improved health outcomes in stroke, depression, and angioplasty treatments. Within 2 years, the CRM initiative had an ROI of +152% and generated $1,052,828 each year.
- GET SATISFACTION: A leading online customer community platform that companies use or customer support, idea submission, marketing and sales questions, and capturing positive feedback, focused traffic driving strategies on search, social media, blogging, and building a content community. The CRM strategy achieved an ROI of +104% in month one, +168% in month two and +248% in month three.
- TYROIT: is Europe's largest manufacturer of bonded grinding, cutting-off, sawing, and drilling tools generating $416 million in annual revenue from more than 70,000 unique products produced in 19 plants for 60 countries. Tyroit used CRM to integrate products and solutions to reduce the number of contact points and transaction costs. It increased bottom line costs by +25% and produced an ROI of +183% within 2 years.
- AT&T: Put together a new sales team to re-build business relationships with a Fortune 100 company in Atlanta. They decided to take an entirely new approach that heavily favored building relationships through social media. They had to try something new. Relationships with a key client had suffered in the past five years, creating strain and sales had dried up. With training from Mark Schaefer and support from our internal team, they began implementing a content strategy aimed at strategic "persons of interest" from the former customer. Inside of 18 months $47 million in brand new business was awarded to AT&T, directly attributable to social media outreach.
- IBM: Traditional ways of finding B2B customers for hardware and software products – telemarketing and email – were not producing the same results when applied to selling web-based services such as cloud computing and data security. IBM launched a program called "intelligent listening" within social media to learn what conversations about cloud computing were going on, what trends and issues were being discussed, and what the hot-button topics in the field were for users. Sales reps could simply check an RSS feed, find some content that fit the context of any discussion they were seeing, and upload them to social media and also to their new individual rep profile pages within the IBM site. The result was 10 orders the first day, and orders for product during the quarter that were 4X higher than during the same time the year before.
- INCONTACT: A call center software company, trained half their team to learn and engage with customers through Social Selling using LinkedIn and the marketing automation software, Eloqua. Within a year, the half of the team that was trained saw a 122% increase in revenue for those sales reps using LinkedIn; 157% increase in revenue for those sales reps using LinkedIn & Eloqua. Now the entire company is trained in Social Selling Here is a brief video to explain the story.
- INDIUM: Social Media in manufacturing is a rarity. Several of their engineers (17 or so, and 73 blogs.) write blog articles to share their expertise with customers, prospects and people with questions about the technical applications related to solder. They shifted from traditional white papers to blog articles, supported by extensive measurements. Video is part of the mix too, to develop high value conversations, and this rolls over into trade show attendance. The video highlights key points for success and insights. SEO improved significantly. Leads increased significantly while trade-show costs decreased 75%.
- HUBSPOT: Focused social media on solving customers' problems as a way to earn leads. For example, HubSpot is first to release guidebooks their target market needs to create success. When something changes in online marketing, HubSpot is there with a guide to manage the change. They share the best advice, fast and have earned a reputation as THE educational resource for the market they serve. They give knowledge and advice (content) away free and make sure it's the very best stuff possible. This (now) famous software start-up exploded onto the scene in 2006. Two years later they hit $2.2 million in sales and $52 million 4 years later.
- LINKEDIN: Had to be converted to social selling. After the release of tools such as Sales Navigator and TeamLink, LinkedIn's own sales team began seeing significant results. Ralf VonSosen, the company's head of marketing for sales solutions notes, "We started seeing a 50% increase in leads to meeting conversion rates."
- LOGMYCALLS: A call tracking service, practiced a"150 Blog Posts in 50 Days" effort. "With a company our size, the commitment has to be significant in order to produce 3 unique and useful blog posts a day," says Inbound Marketing Manager, McKay Allen. "After all, we also produce 2 original marketing webinars each week, monthly case studies, a variety of marketing White Papers, and some humorous and awesome marketing call tracking videos." The result of this original and relevant content: A 400% increase in leads within 90 days.
- AXWAY: Is a software service that manages, runs, secures, and monitors all your business interactions – emails, files, messages, services, events, and processes. Although Google Adwords was successful at generating leads for Axway, competition for top keywords was fierce and drove up conversion costs. Axway used LinkedIn Ads specifically targeting the job titles, industries and job functions. They tested over 30 ads with custom landing pages. The LinkedIn campaigns generated +25% conversion rate with the lowest cost per conversion ever achieved.
- JMF INTERNATIONAL TRADE GROUP: Is a business consultancy and contract manufacturer run by James Filbird. What Jim did is something any of us could do to grow a business but most of us don't. He: 1) kept his profile up-to-date, 2) joined 50 LinkedIn Groups, 3) scoured Group Digests, 4) engaged in discussions, 5) connected, 6) moved the conversation offline, mostly through Skype and 7) re-evaluated his groups and contacts, regularly. He attributes the company he built to $5,000,000 in revenue largely to LinkedIn.
- GOSHIDO: a software solution that makes is easier for people around the world to work together and collaborated, used LinkedIn to find seed capital for its own creation. This was done by identifying and leveraging connections who could be potential investors. Approximately $150,000 was raised.
- HEWLETT PACKARD: is the first company to hit 1,000,000 Followers for a Company Page. They also set up a specific Discussion Group to attract small businesses that has 5,500+ members; 75% who actively engage in discussions and who are 2X more likely to recommend HP. Since a video tell more than 1,000 words, here's the story.
- INSPIRED MARKETING: Sells digital materials and online training programs about using social networking tools such as LinkedIn, Facebook and Twitter to create and market a successful business. In 2010, the partners presented more than 300 webinars (both their own and through other people). They investment could be tracked to over $2.5 million in sales for 2011. "In January 2011, we had sales of $250,000 from just seven GoToWebinar events," says President and Co-founder, Lewis Howes.
- LUMEDX: Is a small healthcare technology company with 100 person staff. It needed to stand out in the face of large brand competition. Lumedx used webinars to cost effectively build awareness of its cardiovascular information and imaging systems product, drive lead generation campaigns and build customer rapport. Lumeds increased contact with over 500 clients, gained competitive edge over much larger companies and drove over$600,000 in annual sales.
- MARKETO: Is a leading provider of marketing analytics software. The company recognized webinars as a key piece in the marketing tool kit to promote thought leadership and generate leads. As with many webinars, people registered but didn't always attend. They used a simple, recorded phone message reminder in addition to email. Although th ephone reminder added $2 for every registrant, it increased conversion of people who attended from 26% to 48% and, according to Marketo, was well worth the investment in terms of sales results according to a company rep.
- PINPOINTE: Is a provider of on-demand email marketing automation services for mid-market and large enterprises. Pinpointe depended upon free,15-day trials of its service together with traditional sales outreach to generate leads and win new customers. However, the company wanted to find additional ways to increase awareness, leads and sales. When webinars were added, 1000 new leads per month are added; 25 become customers who each generate $200/month in Pinpointe services adding $6,250 and $75,000 to the bottom line.
- SEAGATE: Is a large 52000+ staff technology company, Seagate wanted to bypass traditional B2B channels and market its new product directly to end users. Webinars facilitated a B2C product launch and attracted 1500+ attendees with zero advertising budget. Seagate also used webinars to assemble far-flung speakers for webcasts without travel costs. Seagate exceeded initial sales unit goal by 300 percent, doubling sales forecast within one week of launch. Once they put the webcast on YouTube, a viral marketing effect created 38,800 within 4 months.
Did you find one relevant to your business? Did these case studies convince you digital marketing works for your B2B business?
Rob Petersen is an experienced advertising and marketing executive and the founder of the BarnRaisers agency anbd a strategic partner of Schaefer Marketing Solutions. Follow Rob on Twitter: @RobPetersen
Illustration courtesy BigStock.
The art and science of developing an enterprise content strategy
May 18th
A year ago, Kevin Green left his job at a marketing agency to become Executive Director of Marketing, Digital Strategy & Innovation for Dell.
There are few companies that are more serious about serving customers through a diverse content portfolio than Dell is. But how does a company develop a comprehensive content strategy that serves millions of customers and thousands of enterprise-level partners? Kevin Green explains how he leads one of the most complex content-juggling acts in the business world.
Mark: In an era when content is being commoditized, how do you continue to look to an enterprise content strategy as a source of competitive advantage for your global business?
Kevin: I think this will depend on a deeper reliance on data and technology. I think when we look at the changes in the platforms and evolving ways people use information, there's more we can do. There are more ways to connect in this ecosystem of social networks — connect people to our own experiences.
The information density you have written about in your Content Shock piece is real. One result is that access gates are being put into place. It's becoming a pay-to-play environment. Content strategy is more about the connection than the content now. The content is a given. I don't believe that we should be paying to build somebody else's audience. Not only just in social, but even across traditional publishers.
There's a value in those relationships, and we need to focus on those connection points. That's the only way to realize a long-term return on our content investment. I think we can do that and have an advantage. Really, I think staying ahead in marketing today is about being adaptive in real time, but not real time in the sense of let's capitalize on this Super Bowl power outage. I mean, real time in understanding trends. The technology in the space is undergoing a huge metamorphosis right now.
Mark: I imagine that in an enormous company there is this content dance that must go on. You are getting pull from internal customers, but you also need to be pushing on the edges of these new ideas you mentioned. Is the pull or the push determining your content strategy? Do you primarily lead or respond?
Kevin: It's really a balance of both, and I would add a third component that determines our strategy and that is economic optimization.
The assets of the content you create are significant and complex, especially in a global enterprise. How do we create new avenues and new opportunities for our content in many regions? How do we create or change perception and drive awareness in different cultures, different channels? We also look at the economics in a very granular way, right down to each stage of the sales funnel and format types. We test calls to action and potentially underperforming tactics and replace them with something that's a little bit innovative and better content investments.
That's a big part of our content culture that gets me so excited — we never stop trying to beat what we did last time. There's always an opportunity to improve, and evolve and innovate.
Mark: One of the things I admire about you is that you were one of the first people I worked with that understood the importance of social influence. How does that connect to your content strategy today?
Kevin: My view has been formed by having been in the space for over a decade and from being a successful blogger early on. I've always appreciated the tremendous level of effort that goes into creating content and the skills required to do that.
When it comes to influence, there has never been this one blueprint to follow. You could look at a Guy Kawasaki versus a Gary Vaynerchuk, and they're completely different in their content creation capability, skills, and approach but both are widely visible and recognizable.
I focus first on the authentic nature of the content people are creating. I've always felt that people navigate toward content that they can relate to, that they can see themselves in.
The biggest problem we have here in marketing is that we put these messages out in the market that we think people want to hear. That outsider's perspective from the influencers should be guiding us through their thought of leadership.
We should be absorbing and consuming this stuff that influencers create versus using them as a testing bed. That's the approach that I've always taken. Don't just give them a product to review. There's a place for that, but there's a level of influencer that truly can change perception, and make people think twice.
We look for people who can bring a unique and original voice to the table and get their content shared. Get people to engage with the content. Get those comments to drive conversation.
What's important for us when we think about influence is, Can you ignite a conversation? Does the conversation drive traffic?
Mark: I've been writing a lot about the priority for content ignition. Content really doesn't deliver economic value unless it moves through an audience. Is Dell starting to think this way at all?
Kevin: Yes, some of that is happening here already. My organization pulled together a content playbook, and it's designed to talk about the evolution of formats and assets, and how to think about creation differently based on the changing consumption habits of our audience. Instead of creating a hundred different pieces of content, we're thinking about how we can create just one thing and then turn it into a hundred different things.
The call to action around all of those distributable, bite-sized little content pieces drive back to this more rich robust content element that you've already set the hook. We're looking at developing content models. We're doing a lot of testing across our customer journey to say, "Look, when your first touch is a video and your second touch is an infographic and your third touch is a blog post, you're tracking people all the way through that consumption process."
We're trying to find what is the right mix of specific formats, topics, lengths to say, "You want to drive awareness. This model is proven to be effective and to drive these types of results. Go create these assets, but know that these assets have to be specific attributes."
I love the idea of content ignition because my team is really focused on how do you move content after that first touch. We think about that top of funnel activity. That's where we feel that influencers play a huge role. The influencers have an innate skill because a great way to move content is to get people to think, get them to respond, get them to engage.
I believe in your ideas in The Content Code. I was particularly interested in the idea of gray social media.
Mark: A lot of people seemed to connect to that idea that many people are telling us in their own way that they love us and believe in us but the metrics don't pick it up.
Kevin: It's very interesting and this is going back to the part about what metrics really matter.
If you're finding these individuals, they're emerging from this gray area and you are embracing them as they emerge — it seems like that is an important thing to track.
This is why I'm not a big fan of these influencer lists or automation tools. In fact I can't stand any of them. I've had people come to me and they say, "But we can identify who your key influencers are," and I will consistently say there are too many moving parts, it's way too fluid.
These people in the gray social media you talk about — they may be the most influential of all if they are quiet advocates. And the people who you think are your most staunch advocates can turn quickly.
Mark: Agree. Those quiet advocates may be the bedrock of your business. I think our metrics need to focus on those folks more. The implications for analytics are getting into those small data, not the big data, and teasing that out, and say, "Wait a minute. There's something special going on here."
Kevin: If I want to scale a content effort across an enterprise, I can get scale from even the smallest inputs. Building a relationship with the passionate fans creates limitless opportunities for me, to expose their stories. That's really what it comes down to.
I think a key strategy going forward is finding ways to nurture and acknowledge these great fans through our content strategy. Involve them, reward them and create something immersive.
I was sitting in on a Twitter chat about our products, and it occurred to me that most of the people on the chat weren't looking for a mention. They were looking for us to notice them as true fans.
That is actually an old-school idea. My father, back in the '70s, was featured in a print ad for a company, because they wanted a real customer in the ad. He saved that print ad for 30 years. People just want to be recognized. That can turn them into huge fans.
Mark: That's a great story.
Kevin: It really is a good story. I think there are deep socioeconomic implications, psychological connections between our fans, our content and creating advocacy. There is probably a psychological profile you could develop for people most likely to share your content. If you dig deep into what people share there are probably consistent themes.
Mark: That connects to your influencer comments too. How do we align with their themes and what they like to share? How do you create content that makes them look cool? Relevant? Informed? That's what will deliver that ignition.
Kevin: Very true. And you have to deliver it in a format that is not going to be outdated in a week.
What my team is really focused on is, not the bright, shining new object, but presenting things in a way that is captivating and immersive. What we are trying to do is, and I don't like the term "tools," because tools sounds too utility-based, but we want to create an immersive experience that allows people to experience and engage and share with us, and there are things that we'll give back to you.
We need to get past the "Click. Consume" and lead to "Click. Consume. Click. Share. Click. Consume. Click. Share." How do you create that environment? That's what we are really trying to expand on.
This post was written as part of the Dell Insight Partners program, which provides news and analysis about the evolving world of tech. For more on these topics, visit Dell's thought leadership site PowerMore. Dell sponsored this article, but the opinions are my own and don't necessarily represent Dell's positions or strategies. Dell was also a sponsor of The Content Code book mentioned in the article and I appreciate their patronage.
Illustration courtesy Flickr CC and Luke Price
If you stopped publishing your social content, would anybody notice?
May 13th
By Brooke Ballard, {grow} Contributing Columnist
If you're like me you don't ever feel comfortable with your social media content publishing schedule. In fact, I have a secret that's been gnawing at me late at night when I should be sleeping. More on that later …
And I think this topic is ripe for conversation. Debate even.
With theories like Content Shock nipping at our heels, and IBM saying the "internet of things" leading to the doubling of knowledge every 12 hours, I think I can speak on the behalf of many other content marketers when I say: I'm freaking out!
What does this mean for the "little guy" and our social content? Do we post more? Less? The same? Do we curate content or only share our own, original pieces?
I'm genuinely very curious to hear what you {grow} readers have to say.
Here are some of my thoughts and research; fodder for the conversation, if you will.
Social Content Homeostasis
On average, my small company shares around 110 posts per week. And that's just considering the "biggies" — Facebook, LinkedIn, and Twitter.
We post weekly to other sites like Pinterest and Google Plus … and then of course there's my personal profile, which is active on each of those sites as well.
According to a study by Locowise, which examined more than 600 pages on Facebook with a total of more than 250 million likes, here's where the majority of brands fall with publishing frequency:
- 31 percent of pages studied posted two to four times per week
- 25 percent posted once per day
- 18 percent posted once per week
- 4 percent posted more than 10 times daily
- 3 percent posted five to nine times per day
So at least for Facebook, we'd fall in the top 56%, posting anywhere from once per day to two to four times per week.
Several advice sites encourage users to post more to Facebook to combat certain algorithm changes.
I am usually an outlier in that I say — post less. And in accordance, the study from Locowise concluded that posting less to Facebook was better for brands relying on organic reach.
Mega sites Buffer and SumAll seem to be more in alignment with less is more as well:
If I were just going off of the above stats, we are:
- Under pinning on Pinterest
- Over tweeting on Twitter
- Under posting on G+
- Good with Facebook
- Under posting on Instagram
- Good with LinkedIn
- Behind on blogging
Which leads me to my next question: Does my small business really need to be everywhere? Or should we concentrate on the places we can do it right?
The Great Content Curation Debate
I realize the term "right" is relative. What works for you may not work for the next guy, and so on.
But as young marketers, and new marketers, and even in-the-know marketers seek to combat the shrill hum of more and more content, how do we use social content to combat it?
Or, more importantly, is social content adding to the noise?
If you were to look at social sharing, for instance, the stats show that most people retweet articles that they haven't even read!
We've found effectively no correlation between social shares and people actually reading (our posts).
A shocking statement by Chartbeat, a real-time traffic analytics company.
Both Chartbeat and Hootsuite found that some readers read every word, many only skim, and even more than that will share without one glance.
Savvy readers understand that sharing and content curation are two different things, as curation is taking sharing to another level.
But what is content curation achieving? Are you building authority? A community? Are you engaging with thought leaders and networking?
Some pundits will tell you that "real brands don't curate" and by sharing others' smart content you are merely promoting them and not making yourself look any smarter.
Either way I suppose there is an argument that sharing others' content is just adding to the piles of unread and uncared about noise.
Where Do You Stand?
Time and resources are finite. As businesses, we need to look at where our time goes and evaluate the measure of how well that time is spent.
Is it worth our time to push 110 posts out to social channels every week? Is that a shotgun approach when we need sharks with laserbeams on their frick'n heads (an Austin Powers reference)?
Would it mean certain death (to a brand) if those posts dropped drastically or disappeared altogether?
Does anyone really care?
Because — I'll be super honest here — even though our company does a stellar job with organic reach, if we stopped posting on social media tomorrow I'm not sure it would devastate us. I'm not even sure anyone but our advocates would notice. Hopefully I'm wrong, but there it is. That's the big hairy secret that's keeping me from catching Zs at night.
I'm asking you to weigh in here, too. Help me understand how the changing social landscape and things like content shock can coincide and live together in peace and harmony.
Please and thank you.
See you in the social sphere!
Brooke Ballard is an in-the-trenches digital marketer & owner at B Squared Media, blossoming blogger, and co-host of @ReadySetPodcast. Her mantra is "Think Conversation, Not Campaign" so be sure to give her a shout on Twitter.
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text:
Kacie Discusses Her Return to 'The Bachelor'
8:37 PM PST 3/5/2012 by David Simpson
Kacie talks about her decision to return to the show in Switzerland to warn Ben about Courtney. The "Bachelor" favorite also explains why her hometown date came across so poorly on TV.
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A Widow's Threats, High-Powered Spats and the Sony Hack: The Strange Saga of 'Steve Jobs'
Hollywood's 100 Favorite TV Shows
'The Martian's' Matt Damon Talks 'Bourne' Return, Politics and PC Flubs: "Oh My God, I Look Like an Asshole"
The Insane Battle Over Sam Simon's Will — Should the Simpson's Co-Creator's Trust Pay $140,000 Per Year For One Dog's Care?
'Empire's' "Batshit Crazy" Behind-the-Scenes Drama: On the Set of TV's Hottest Show
Hollywood's Notable Deaths of 2015

subset: commoncrawl


text:
Mehdi Hasan exposes misconceptions about the continent
Explore Japan through its offbeat train culture
11 Nov 2013 16:34 GMT | Politics, Asia Pacific, Thailand
Thailand's senate has unanimously rejected a contentious political amnesty bill, the deputy speaker said, as tens of thousands of anti-government protesters massed on Bangkok's streets.
"This house rejects this bill for consideration," Surachai Lengboonlertcha said, adding all of the 141 senators present voted against the legislation, which critics say was aimed at helping divisive former premier Thaksin Shinawatra return to Thailand from self-exile.
The decision kicks the bill, which has provoked nearly a fortnight of protest on the capital's streets, back to the lower house, where under pressure Prime Minister Yingluck Shinawatra - Thaksin's sister - has already vowed to kill it.
Mass protests
It was holding an anti-amnesty rally on Monday evening - before the expected vote by the senate - which it said could draw tens of thousands to the city's political centre, heightening fears of clashes with police.
A Democrat lawmaker Akanat Promphan said the protesters would give the government a "deadline" of 6pm (11:00GMT) to kill the bill before taking further - as yet unspecified - actions.
Thousands of police were deployed across Bangkok to keep the peace, including nearly 7,000 officers around the parliament and the prime minister's office.
Since it was passed by the lower house on November 1, the bill has set off daily demonstrations and raised fears of reviving political turmoil that has convulsed the country since Thaksin was toppled by a coup in 2006.
Opponents of the amnesty say the legislation is intended to whitewash Thaksin's alleged crimes and allow him to return to Thailand without going to jail.
Thaksin fled into exile to avoid serving a two-year prison term for corruption.
Source: Agencies
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Education Pro enables teachers to monitor students' online activity and sends "violation" alerts over trigger terms.
Human Rights, Education, United Kingdom
Japanese protesters invoke human rights abuse and painful memories of war to oppose US Marine airbase on their island.
Military, Human Rights, Japan
Precarious peace agreement has failed to end fighting in South Sudan with fears of famine and disease outbreaks.
War & Conflict, Human Rights, South Sudan
While targeting 'terrorists and junkies', Kremlin-backed strongman Kadyrov flaunts the law to safeguard moderate Islam.
Human Rights, War & Conflict, Chechnya
Armed group says it controls most parts of city after it was briefly taken by government forces backed by US strikes.
War & Conflict, Middle East, Afghanistan
Only residents, business owners and students will have access to area, after two attacks in less than 12 hours.
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101 East follows the lives of seven people in Nanjing and asks what they think of the direction their country is taking.
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In a Delhi slum, puppeteers, musicians, jugglers and acrobats try to unite as they wrangle with an approaching eviction.
Business & Economy, Arts & Culture, Poverty & Development
An investigation into the high rate of child sex abuse in Jamaica and the government's failure to protect its children.
The story of the 1994 Rwandan genocide told through the prism of the media, exploring their role then and today.
Media, War & Conflict, Africa


text:
Almost exactly 5 years ago (wow!) I suggested that those looking for a city commuter bicycle in the $500 price range consider a refurbished vintage 3-speed, in leu of what was then available new for the same cost. My reasoning was, they would be getting a product both higher in quality and pleasanter to ride than the then-available alternatives.
Today, the economic landscape is changed from what it was 5 years ago. Nevertheless, the $500 figure remains amazingly stable as the budget those looking to buy their first city bike quote me. Luckily, the bicycle industry has changed as well. More options for budget priced city bikes are available now than there were 5 years ago. Is it still worth it then, to attempt going the vintage route? Here are my updated thoughts on the subject.


text:
Madison is Among The Top Cities Where Millennials Are Taking Over the Housing Market
Categories: New Homes Madison | Posted: October 1, 2015
The Cities Where Millennials Are Taking Over the Housing Market-Hint: Not in the most expensive cities.
Millennials are dominating the Des Moines housing market. That's an odd piece of information that seems a little less odd—and a little more important—the longer you ponder it.
Roughly 60 percent of borrowers who used a mortgage to buy a home in Iowa's capital city during the first half of 2015 were aged 25 to 34, according to data from Realtor.com. That compares with a national average of 37 percent, and makes Des Moines the most millennial-friendly city in the U.S. Here's the rest of the top 10.
Most of those cities don't enjoy reputations for being particularly hip. What they are, generally, is cheap—and probably a little hipper than they get credit for. That makes a difference as young homebuyers finally shake off the effects of the recession and enter the housing market.
Historically, people 25-34 have made up the largest share of homebuyers, said Jonathan Smoke, chief economist for Realtor.com. (More specifically, Smoke cited data that showed the age cohort is the most likely to take out a mortgage to buy a home, rather than to refinance.) The explanation is straightforward. People in their early 20s are less likely to be ready to buy, and people past their mid-30s are more likely to have already bought.
The millennial generation has bucked that trend, for reasons that have been cause for disagreement and consternation. Slow wage growth, student loan debt, a preference for city living, and a tendency to start families later have all been posited as reasons millennials have been slower to buy than previous generations.
The new findings may lower some of the alarm about first-time homebuyers. Thirty-seven percent of mortgage borrowers who bought homes were millennials, up from 31 percent in 2014. A survey conducted by Realtor.com, meanwhile, found the most common reason millennials decided to buy homes this year was that they were making more money.
It helps that it costs a lot less to buy in Des Moines, where the median listing price in August was $218,000. (In San Francisco, it was $738,000.) But it's also easy to forget that there are attractive jobs in all kinds of places—about half of jobs in science, tech, engineering, and math are located in the 20 biggest U.S. metros. The rest are in places like Huntsville, Ala., and Lincoln, Neb., cities that offer the appeal of lower costs of living. "It's so 2012 to say young people are doing miserably," said Smoke. "This age cohort is benefiting from the kind of economy and job growth we've been having."
Source: Bloomberg Business; Patrick Clark September 28, 2015


text:
Page 1
The Origin of Allosteric Functional Modulation: Multiple Pre-
existing Pathways
Antonio del Sol1, Chung-Jung Tsai2, Buyong Ma2, and Ruth Nussinov2,3,*
1Bioinformatics Research Unit, Research and Development Division, Fujirebio Inc., 51 Komiya-cho,
Hachioji-shi, Tokyo 192-0031, Japan
2Basic Research Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology
Program, NCI-Frederick, Frederick, MD 21702
3Sackler Inst. of Molecular Medicine, Department of Human Genetics and Molecular Medicine,
Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
While allostery draws increasing attention, not much is known about allosteric mechanisms. Here
we argue that in all proteins, allosteric signals transmit through multiple, pre-existing pathways;
which pathways dominate depend on protein topologies, specific binding events, covalent
modifications and cellular (environmental) conditions. Further, perturbation events at any site on the
protein surface (or in the interior) will not create new pathways but only shift the pre-existing
ensemble of pathways. Drugs binding at different sites or mutational events in disease shift the
ensemble toward the same conformations; however, the relative populations of the different states
will change. Consequently the observed functional, conformational, and dynamic effects will be
different. This is the origin of allosteric functional modulation in dynamic proteins: allostery does
not necessarily need to invoke conformational rearrangements to control protein activity and pre-
existing pathways are always defaulted to during allostery regardless of the stimulant and
perturbation site in the protein.
Allostery; propagation; cellular signaling; allosteric drugs; pathways
Proteins are the 'workhorses' of the cell. Their response to changes in the cellular environment
is modulated by an effector. The effector perturbs one site and thereby leads to an altered
activity in a second, substrate site. Allostery is regulation at a distance by conveying the
information from the first site to the second. Allostery is relayed through the cellular membrane,
the cytoplasm and into the nucleus amplifying signaling (Ma and Nussinov, 2009) and the
signals are sent dynamically (Smock and Gierasch, 2009). Allostery can result from physical
binding events (with proteins, DNA/RNA, small molecules, lipids); light, as the photoswitch
LOV2-Jα illustrates, fluctuating between 'dark' inactive and 'light' active conformations (Yao
et al., 2008); mutational events; covalent modifications (phosphorylation, glycosylation,
*Correspndence should be addressed to Ruth Nussinov, email@example.com; Building 469, Rm 151, NCI-Frederick; Phone:
301-846-5579; Fax: 301-846-5598.
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we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting
proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could
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NIH Public Access
Author Manuscript
Structure. Author manuscript; available in PMC 2010 August 12.
Published in final edited form as:
Structure. 2009 August 12; 17(8): 1042–1050. doi:10.1016/j.str.2009.06.008.
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tethering (Hardy et al., 2004); or changes in the environment (pH, temperature, ionic strength,
etc). Allostery was originally described in oligomeric systems (Changeux and Edelstein,
2005). Two recent reviews (Cui and Karplus, 2008; Goodey and Benkovic, 2008) provide a
historical perspective: the first highlights cooperativity; the second emphasizes that catalysis
and allostery emerge via common communication routes. Key questions include
comprehensive description of allosteric mechanisms (Tsai et al., 2009), prediction of allosteric
sites whether on the protein surface or of residues whose mutation could lead to allosteric
effects, the pathways through which signals travel, and allosteric drug discovery. Currently,
observation of specific pathways experimentally is a challenging problem. However, NMR
provides information on protein dynamics from which pathways can conceivably be inferred
(Boehr et al., 2006; Kern and Zuiderweg, 2003; Swain and Gierasch, 2006; Volkman et al.,
2001). Recently, using NMR relaxation dispersion techniques the dynamic process through
which the KIX domain of CREB binding protein communicates allosteric information has been
directly observed (Bruschweiler et al., 2009), revealing that information is transmitted through
an evolutionarily conserved network of residues. Below, we first briefly describe the principles
of allostery, the "old" view, the so-called "new" view and an "updated new" view (Tsai et al.,
2008). The "updated new" view leads us to re-address some of these questions. In particular,
it highlights an allosteric property which has largely been overlooked: allostery invariably
involves multiple pathways. Multiple pathways can relate to mutational effects in disease; to
modulation in signaling pathways and to drug discovery. However, key to allostery, regardless
of the site and nature of the perturbation events propagation will take place via the same
pathways. The different perturbation events will simply shift pre-existing populations. This is
the origin of allosteric modulation in cellular pathways and in drug binding effects.
The "old" view, the "new" view and the "updated new" view
An emerging definition based on pure thermodynamic terms
Over the years, static pictures of allosterically-regulated proteins indicated a change in the
shape of the substrate binding site between the On/Off states depending on whether the effector
molecule was bound at the allosteric site. This has led to the paradigm that allostery involves
conformational change. The two classical models, the Monod-Wyman-Changeux (or, MWC
for short) (Monod et al., 1965) and the Koshland-Nemethy-Filmer (KNF) (Koshland et al.,
1966), described allostery as a binding event at one site altering protein activity via a
conformational change at the second site. The MWC model (Monod et al., 1965) emphasized
that the conformational transition is a concerted action between two co-existing, distinct states
(relaxed and tense, or R and T); on the other hand, the KNF model (Koshland et al., 1966)
formulated it as a sequential, induced conformational change by the binding at the first site.
The classical "old" view rested on two assumptions: that there are two distinct conformations
and in the absence of a ligand their ratio is governed by the equilibrium constant; and that
allostery involves a change of shape. In contrast to the "old" view, the more recent "new" view
recognized that the native states are ensembles of pre-existing populations; thus, an allosteric
effector leads to an equilibrium shift of pre-existing conformational and dynamic states
(Gunasekaran et al., 2004). Now, the "updated new" view posits that allostery does not
necessarily even involve a change of shape (Tsai et al., 2008). Recent data (Daily and Gray,
2007; Popovych et al., 2006; Tsai et al., 2008) validate the theoretical proposition (Cooper and
Dryden, 1984), indicating that even if there is no visual change in the shape of the backbone
at the substrate binding site upon binding of the allosteric effector, there could still be an
allosteric change in the substrate binding site, and in protein activity. Popovych et al. (Popovych
et al., 2006) presented direct experimental evidence illustrating that allostery can be mediated
solely by changes in protein dynamics without any conformational change. Daily and Gray
assembled an allosteric protein benchmark of pairs of known inactive and active allosteric
protein structures from the Protein Data Bank (Berman et al., 2002). The dataset includes
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structural-pairs with no or subtle conformational change, governed largely by entropy (Daily
and Gray, 2007). This absence of conformational change leads to a definition of allostery in
pure thermodynamic terms: allostery can be controlled by enthalpy; by enthalpy and entropy;
or solely by entropy (Tsai et al., 2008; Tsai et al., 2009). This "updated new" view is important
since it helps in understanding allosteric mechanisms and thus in prediction of allosteric sites,
allostery-related residues, allosteric drugs, and allosteric modulation.
Allostery involves multiple pathways between the perturbation and the substrate binding
sites and dynamic transitions
The "old" view defined allostery in terms of two discrete states. It sought a single, well-defined
propagation pathway between the allosteric- and substrate-binding sites which would lead to
a conformational change. All allosteric residues were on this pathway and the signals were
assumed to be transmitted by mechanically forming and breaking noncovalent interactions
between on-pathway residues (Figure 1A). The old view was unable to offer an explanation
for disease-causing (or, preventing (Trible et al., 2007)) mutations which were not at the
binding sites, retained the global protein conformation, and did not lie on that pathway. In
contrast, in the "new" view (Figures 1B,C) it is not a specific propagation pathway but an
ensemble of states (Gunasekaran et al., 2004) that is the key for allostery; thus multiple
pathways, major and minor, between the allosteric and the substrate binding sites. At the
allosteric site noncovalent binding, covalent modification such as tethering, phosphorylation,
or a point mutation create local stress. Local stress perturbs the structure, and the perturbation
propagates via multiple pathways from the allosteric to the substrate binding sites. The PDZ2
domain interacts with a C-terminal peptide ligand obtained from the Ras-associated guanine
nucleotide exchage factor 2 (RA-GEF2). It is known that binding site histidine 71 (hPTP1E
PDZ2 numbering) determines the PDZ2 specificity, defining PDZ2 as class I PDZ domain
(Kozlov et al., 2002). For the PDZ domain family, Ranganathan and coworkers predicted and
confirmed experimentally a set of energetically-coupled positions for the binding site residue
His71. In Figure 2a, this set of residues has been mapped onto the PDZ2/RA-GEF2 structure,
forming a pathway that starts at the RA-GEF2 binding site and ends on the opposite side of
the domain. Side-chain methyl dynamics measurements on the PDZ2 domain showed that
allosteric transmissions due to RA-GEF2 peptide binding may be dominated by side-chain
dynamics (Fuentes et al., 2004). Residues whose side-chain dynamics changed significantly
upon peptide binding are also illustrated in Figure 2a. These residues form an alternative
pathway starting at the peptide binding site and ending at two distal surface regions from the
peptide binding site (see legend to Figure 2). These two pathways share common residues
belonging to the protein core and distal surface 1. These findings based on the PDZ domain
suggest the existence of multiple pathways from the perturbation to the substrate binding sites.
The KIX domain of the CREB binding protein CBP provides another example of an allosteric
protein with experimental data supporting the presence of multiple allosteric communication
pathways. The KIX domain binds the mixed lineage leukemia transcription factor (MLL)
inducing binding of the activation domain from c-Myb (Goto et al., 2002). Recently, using
NMR relaxation measurements, a pathway through which the allosteric information is
transmitted upon MLL binding has been observed (Bruschweiler et al., 2009). This pathway,
which is formed by hydrophobic amino acids experiencing significant structural
rearrangements, proceeds from the MLL binding site toward the c-Myb binding site (Figure
2b). Interestingly, a previous NMR study identified a set of residues exhibiting significant
backbone amide chemical shift changes upon MLL binding (Goto et al., 2002). These amino
acids form a hydrophobic groove that contains MLL binding site residues and other solvent
exposed residues belonging to a distinct protein surface and are possibly involved in binding
of other ligands (Figure 2b). Thus, in this example experimental results suggest the existence
of two pathways that transmit the information to different protein surface patches.
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An allosteric network has also been recently detected in caspase 1 (Datta et al., 2008). Of
particular interest, 21 hydrogen bonds from nine side chains belonging to this network which
connects the active and the allosteric sites were observed to alternate between the on-state and
the off-state. Alanine-scanning mutagenesis of these side chains has shown that only two of
these (Arg286 and Glu390), which form a salt bridge have major effects on catalysis, reducing
it by 100- to 200-fold. Two neighboring residues, Ser332 and Ser339, have minor effects,
causing 4- to 7-fold reductions, suggesting that the salt-bridging residues are on the major
allosteric pathway, whereas the neighboring residues may reside on a minor communication
pathway (Figure 3). Further, even a homologous substitution of the salt-bridging residue
R286K causes a large 150-fold reduction. The structures of these variants suggest that in
addition to salt bridge formation, these residues play an important role in the coordination of
solvent water molecules near the allosteric binding pocket. A critical salt bridge important for
specificity in discriminating between binding partners, has also been detected in p160
coactivator ACTR (Demarest et al., 2002). Computationally, major and minor pathways have
been detected in the tRNA synthetases (Sethi et al., 2009).
Though not formulated in allosteric terms, Ansari et al. (Ansari et al., 1985) pointed out that
similar to an earthquake, stress released from the focus could dissipate through propagation of
deformation, and in the form of waves. From the theoretical standpoint, as in protein folding
and in earthquake, in protein allostery a realistic scenario involves preferred pathways under
given conditions. In principle, which pathway dominates can be determined from mutational
effects: a mutation with a significant effect lies on a major pathway; a minor effect suggests a
minor pathway. Mutations can break native state interactions and make new interactions
(Figure 3). While mutational effects can be assessed by the extent of the allosterically-related
conformational change, this is not necessarily the case. The perturbation caused by the effector
could be reflected solely in entropy changes with no observable conformational change (Tsai
et al., 2008), as illustrated by Popovych et al. (Popovych et al., 2006) and in structural
comparisons of different allosteric states (Daily and Gray, 2007) (Figure 1C). The changes in
entropy reflect all pathways under given conditions; that is, the landscape. Further, the "new"
view is based on pre-existing equilibrium, invoking transitions between protein conformational
and dynamical states (Formaneck et al., 2006; Kumar et al., 2000; Ma et al., 1999; Ma et al.,
2002). Thus, key allosteric residues, predicted via coupling between residue-pairs quantified
by statistical coupling energies (Suel et al., 2003) or experimentally identified by double-
mutant cycles (Horovitz and Fersht, 1990), are not only those lying on the communication
paths (Horovitz and Fersht, 1992; Sadovsky and Yifrach, 2007) but also those important for
conformational and dynamical transitions. Mutations affecting these transitions could get the
protein trapped, hindering population shift. Topologically, protein structures can be
computationally decomposed into energetically independent modules, the building blocks of
protein domains (Hu et al., 2007). Inter-modular residues play a key role in signal transmission.
These residues are rigid, sustaining key amino acid interactions for the communication between
modules. Most of the inter-modular residue interactions form long-range contacts that are
predominantly involved in mediating signaling. Multiple pathways between the perturbation-
and the substrate-binding sites are likely to share such central residues, but to diverge in
modules. Further, recently, comparisons of crystal structures of the inactive and active forms
of protein pairs led to identification of 'rigid bodies' (Daily and Gray, 2009). Analysis of the
interactions between these showed that they are cyclically connected, again associating protein
motions with network organization. Thus, multiple pathways always exist even if undetected
by experiment; they can be reflected in dynamics and in conformational changes. The question
is whether they encode different functions. Currently, no such cases are known, probably since
it is only a matter of the relative concentration of the populations thus not sufficiently robust
and sensitive to conditions.
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What is a pathway?
Above, we related to pathways through which the signal is communicated between sites. A
pathway implies a specific sequence in time and space. A pathway consists of a set of residues
which are in (dynamic) contact. Allosteric pathways in a protein can be visualized as strain
energy, created by a perturbation at the effector's site, radiating out to ease the unbalanced
energy through residue-residue interactions (Figure 3). Theoretically, in terms of such a
description, allosteric pathways are the outcome of a summation of many individual micro-
pathways. Here we define a micro-pathway as a specific linkage starting from a residue at the
perturbation site which follows a specified residue-residue interaction path down to a residue
at the second (substrate) binding site. If the weightings for all residue-residue interactions in
a protein are known, a statistical evaluation of the frequency for each residue to be on the
pathway that conducts the allosteric wave from the effector's site to the second (substrate) site
can be computed through a complete enumeration of all micro-pathways. In our definition, the
pre-existing (major and minor) pathways are the outcome of a visualization of the linkage based
on selected residues with a high statistical frequency above certain scale. The caspase-1
functional 'hot wire' or 'allosteric circuit' (Datta et al., 2008) provides an excellent
experimental example for major and minor pathways detected via mutagenesis studies
illustrating our point.
What are protein conformational and dynamical states?
Above, we further related to protein conformational and dynamical states. A conformational
state is determined by its associated free energy. For example, a binding event at the allosteric
site shifts the population of the unbound (conformational) state to a bound (conformational)
state. It is determined purely by thermodynamics. The change at the substrate site, however,
is determined dynamically via residue-residue interactions to release the created strain energy
if there is a conformational change at the allosteric site. If however, there is no conformational
change at the allosteric site, the stiffness (i.e. lose of entropy) will still propagate dynamically
through residue-residue interactions down to the substrate site.
There are not one, but multiple allosteric perturbation sites
Above, signal transmission occurred between two sites: the effector and the substrate. This
situation rarely occurs in vivo. In the cell, all dynamic proteins have more than a single effector
perturbation site. Proteins generally function when in large assemblies, and when regulated by
multiple coincident environmental changes, binding or modification events. Let us consider
the following multiple co-occurring perturbation scenarios: (i) only two molecules bind;
however, external conditions change; (ii) disease-related mutations occurred as for example in
the pVHL which still needs to bind its substrate and partner proteins (Knauth et al., 2006);
(iii) there are more than two binding sites, as in tumor suppressor protein p53 (Riley et al.,
2008); pVHL (Ohh et al., 2000); or regulatory proteins in the ubiquitin ligase E3 complex
(Hao et al., 2007); (iv) there are multiple modification sites in the protein, for example
phosphorylation sites on the p53 (Riley et al., 2008), or acetylation (Luo et al., 2004); (v)
enzymes or receptors which recognize a large number of substrates, such as the kinase which
must recognize between one and a few hundred phosphorylation sites, while at the same time
discriminating an order of magnitude more potential phosphorylation sites in the kinome
(Ubersax and Ferrell, 2007), arguing for possible allosteric modulating effectors; (vi)
dynamically co-regulated proteins which have to respond to complex cell signals (Komurov
and White, 2007); (vii) and finally, binding sites shared by different proteins (Keskin and
Nussinov, 2007; Tuncbag et al., 2009). The conformations and dynamic effects of these are
condition- (i.e. perturbation)-dependent. Clearly, each phosphorylation, mutational, covalent
ubiquitination, nucleotide-binding or change in the environment is a perturbation event.
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text:
Former Food Network chef Juan-Carlos Cruz has gone from cooking to central booking.
Santa Monica police arrested Cruz, 48, on May 13 for solicitation to commit murder after uncovering a scheme in which he allegedly approached homeless men and asked them to kill someone.
According to reports, at least one of the men allegedly contacted by Cruz informed police of the plot. Law enforcement immediately launched a week-long undercover operation and arrested Cruz on Thursday at a local dog park.
Cruz's intended target – whose identity has yet to be revealed – has been notified of the plot, police said. Authorities have also yet to indicate a motive.


text:
Cubavera men's shadow box camp shirt
Cubavera men's shadow box camp shirt
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Cubavera Shadow Box Camp Shirt. Latin-inspired, executive apparel. Features: Sand washed for softness , Coconut shell buttons. Cubavera streamer on inside placket. Tonal pineapple logo on right sleeve. Left chest pocket. Same as style C3S5402 An all around casual summer shirt. It's the first shirt you will pick from your closet when wanting something fast and comfortable.
- Tropical Style
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- easy care
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text: The California Telehealth Network was lauched this week and it will be the largest in the Country. It will connect over 800 California healthcare providers in underserved areas to a state- and nation-wide broadband network dedicated to healthcare. This has been in the making for a while and the launch is pretty big news for California and telehealth, which includes telemedicine and remote monitoring.


text:
Podcast Player1.0
editor's review
1 comment
Podcast Player is a software program developed in Adobe AIR that provides users with a simple means of accessing your favorite podcasts and playing them.
Seamless setup and easy-to-handle environment
The installation process is a piece of cake, as it does not take very long and it does not offer to download any kind of third-party product. After you complete it, you come by a minimal and clear-cut UI, as it is comprised of a few buttons, a pane in which to view available podcasts and another one for episodes.
Although no Help contents are supported, Podcast Player is accessible to all user categories, including people with little or no previous experience with computers.
Playback controls and other options
This utility enables you to listen to your favorite podcasts by automatically detecting them from your hard drive and displaying them in the main window. In addition to that, you should know that playback controls are incorporated, which enable you to play, pause, resume and stop an item.
A progress bar lets you approximate how much time is left from the podcast, while it is also possible to enable an auto-play mode, so that you do not have to manually change the episodes. No other notable options are supported.
Conclusion and performance
The amount of resources required is low under all circumstances, meaning that the system's performance is not going to be affected, the response time is good and the interface is accessible to all user categories.
Taking all of this into consideration, we can safely say Podcast Player is a small, yet pretty handy piece of software and a good decision for people who like podcasts on a regular basis.
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45 Creative Examples of Large Typography In Web Design
The history of typography might be as old as man. Huge typography can swiftly grab the attention of site viewers. Selection of the right typography is considered one of the most prioritized tasks in web design. In fact, design can be revolutionized by using the power of words. Huge typography has become the web designer's favorite tool to communicate because it helps them to excite the experience of visitors by loudly conveying their message. Huge typography can be used anywhere on the page, it looks cool in the header and makes a panache design when used in text, or is even enhancing if used in a tag line. Here we have gathered some very creative layouts using huge typography.
45 Creative Examples of Large Typography In Web design
"Sometimes going big turns out great!" the same happens if huge typography is used in web layout. What matters is the right selection of typography in design.
Make a contrast of bright solid color with comparatively lighter background or write one key sentence in a big font to express your scheme vociferously. The layouts showcased here show how creative huge typography can be when used in website design.
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While new world champion Magnus Carlsen of Norway was taking a Silicon Valley victory lap, GM Levon Aronian of Armenia was winning the first major tournament of 2014 and in the process making a strong statement that he might be Carlsen's most dangerous challenger in the candidates' cycle ahead.
Aronian, the second-ranked player in the world behind Carlsen, decisively won the 76th Tata Steel Chess Tournament in Wijk aan Zee and other cities in the Netherlands. Aronian finished at 8-3, 1 points ahead of Dutch GM Anish Giri and Russia's Sergey Karjakin, clinching first place with a round to go. The Armenian star, who now has won Tata four times, would have finished an eye-popping 9-2 in the event but for a last-round loss to veteran Dutch star Loek van Wely in which the Armenian, in a very strong position, overlooked a mate-in-one in time pressure.
Equally impressive, the 31-year-old Aronian manhandled some of the young guns who are seen as his chief rivals in the bid to take on Carlsen, defeating both U.S. No. 1 Hikaru Nakamura and Italian GM Fabiano Caruana at Tata.
Speaking of young guns, rising American star GM Kayden Troff of Utah got his first taste of elite international competition, playing in the strong Tata Group B flight. It wasn't exactly a Pillsbury-Hastings 1895 moment for Troff: He won his debut game against Holland's IM Marijn van Delft, but would not win another full point, finishing in a tie for 11th at 4-8. Croatian GM Ivan Saric won with a fine 10-3 score, with legendary Dutch star Jan Timman, now 62 and an infrequent competitor on the international stage, claiming second place on tiebreaks ahead of Georgian GM Baadur Jobava.
Carlsen, meanwhile, was enjoying the perks of a champion. He was spotted giving a simultaneous exhibition to a group of employees at Google's Mountain View, Calif., headquarters (he won every game) and later checkmated Microsoft billionaire Bill Gates in a casual game in all of nine moves. (Gates is an avid bridge player, so perhaps he should get a pass on this one.)
Aronian isn't always as flashy as some of his peers, but his play has a rigor and beauty all its own. The decisive game at Tata came in Round 9, when the Armenian was clinging to a half-point lead against Karjakin when the two sat down to play. The Russian used a Queen's Indian line he had employed last year to defeat Aronian, but this time White came prepared.
Black's 18. Nf4 Qd6?! is the first new move of the game, but Karjakin quickly gets into trouble after 19. Bxf6 Bxf6 20. cxd5 exd5!? (Nxd4 was an interesting alternative, with the idea of 21. dxe6 Bxe5 22. Bxb7 Rab8 23. exf7+ Kh8 24. Be4 Bxf4 gxf4 Rxf7, with good compensation for the pawn) 21. Bxd5 Bxe5 22. dxe5 Qxe5 23. Re1 Qf6 25. Qg4 Qg6 26. Qh3! (keeping the pressure on; White's original plan to trade queens here would have given Black some breathing room), with a clear initiative for White.
White cashes in with a mini-tactic after 30. Rbc1 Kh8? (the "threat" was 31. Rxc6 Bxc6 32. Ne7+, although things aren't so clear after 31…Rxd5 32. Rc7 Rh5 33. Qg4 Bxe4 34. Qxe4 a5; safer anyway here for Black was the straightforward 30…Rfe8) 31. Nxb6! axb6 32. Bxc6 Bxc6 33. Rxc6 Rd2 34. Qh4! (Rxb6?? Qd4 and Black wins) Rxa2 35. Qb4! h5 36. Qxb6, winning a pawn.
Aronian's endgame play is impressive, coolly allowing his kingside to fall while pressing forward with the precious b-pawn. Things come together nicely on 51. b5 Kh3 (f5 52. Kd4 f4 53. gxh4 gxh4 54. b6 Kh3 [h3 55. Rb3!, as in the game] 55. Ke4 Kxh2 56. Kxf4 h3 57. f3+ Kg1 58. Kg3, arriving just in time) 52. gxh4 gxh4 53. f4 Kg4 54. b6 f5 55. Kd4 Kxf4 56. Rb3!, and the rook is perfectly placed, cutting off the Black king while supporting the White passed pawn.
It's over on 60. b7 f4 61. Rg7, and Black faces 61…f3 62. Kc7 f2 63. Rf7 Rg8 64. b8=Q; Karjakin resigned.
Top-level tournaments rarely feature miniatures, as elite grandmasters are not in the habit of losing quickly. Oddly, the premier Tata tournament had a pair of shorties, with German GM Arkady Naiditsch going down in 19 moves (with White!) to India's Pentala Harikrishna, and Cuba's Leinier Dominguez Perez needing just 21 moves to take out young Filipino GM Wesley So.
So's Petroff Defense is supposed to be one of the most drawish defenses in chess, but White castles long and launches an early kingside attack. Black looks solid up until 15. h5 Re8 16. g4 g6? (violating the old rule not to move pawns in front on one's king before it is absolutely necessary; fine for Black were 16…d4 17. h6 g6 18. cxd4 Bxf3 19. Qxf3 Qxd4; or even 16…h6!? 17. Qf5 Re6 18. Rde1 Qd7 19. Qh7+ Kf8 20. Bf5 d4! 21. Bxe6 fxe6 22. Qd3 Qd5 23. Rh3 Qxa2, with good compensation) 17. hxg6 hxg6 18. g5 Bg7 (see diagram; 18…Be7 19. Bb5 Rf8 20. Qh4 is also strong for White) 19. Rh7!, a stunning offer of the rook.
Now 19…Kxh7? loses to 20. Qxf7 Re7 21. Rh1 mate, while Black must deal with the threat of 20. Rdh1 Qe7 21. Bf5!! gxf5 22. Qh2 f6 23. g6 Qe2 Rh8+ Bxh8 25. Qxh8 mate. A rattled So fails to find the best defense and goes down quickly: 19…d4 20. Bc4 Qe7?? (mandatory was 20…Bxf3, with survival chances after 21. Rxg7+ Kxg7 22. Qxf7+ Kh8 23. Qxg6 Re7 24. Qf6+ Rg7 25. Qxf3 Qxg5+ 26. Kb1) 21. Qh4!, and Black resigns facing 21…Bxf3 Rxg7+! Kxg7 23. Qh6+ Kg8 24. Qxg6+ Kf8 25. Qh6+ Kg8 26. g6 and mate in a few more moves.
Aronian-Karjakin, 76th Tata Steel Masters Tournament, Wijk aan Zee, Netherlands, January 2014


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- Product Dimensions: 53 x 40 x 62 inches ; 330 pounds
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Refrigerated food bar has aluminum encased copper tube evaporator panels to improve heat transfer by increasing contact area. Compressor is housed in 16 gauge galvanized structure. Precision electronic thermostat for exact temperature control. 1⁄4" Lexan sneeze guard included. 471⁄8"Wx471⁄8"Dx563⁄20"H. 4" casters. 300 lbs. Matte Black vinyl clad steel finish Stainless steel one-sided tray shelf 3 wells 120V, 6 ft. cord and plug included
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TWISTED Beggs, 53, who is serving life for murdering and dismembering Barry Wallace, 18, was targeted by violent offender Daniel Hamilton.
THE Glasgow gang are believed to have been behind the spate of torture kidnappings in Scotland, including one abduction which resulted in a man being kneecapped.
David Cameron today said the UK will double its number of killer drones and 'beef up' the SAS to take on ISIS
THE Paisley-born politician, who backed Liz Kendall in the Labour leadership race, agreed to stay on as shadow Europe minister after he was assured that his party would fight to remain in the European Union.
JEN FOSTER gave her husband Dan her heart, then her liver and now she has given him the best gift yet – a baby boy.
THIS year marks half a century since the release of Thunderball, so it's apt we mention the movie several times in our list.
HELM was given £5000 to establish the company - five years later it's been rapped for making 6 million nuisance calls.
When a man logged into a woman's account on Facebook six years ago today, something incredible transpired
Scottish Daily Record


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Urban Street Fiesta
The new Ford Fiesta is the talk of the town with limitless possibilities for customizing! Doug Breuninger, rendering artist for G.A.S., interprets the kinetic urban soul of L.A. with his complex hand drawn artwork that G.A.S. conveyed into vinyl graphics.
G.A.S. then dropped the vehicle with H&R lowering springs, added a 3D Carbon body kit, installed 18" custom painted Motegi wheels, Continental tires, tinted windows and exterior headlamps/taillights. The result: a trendy, urban, fully customized Fiesta! The 2011 Ford Fiesta also features a 1.6L Ti-VCT Duratec® I4 Engine and a fully integrated SYNC system with 4" multifunctional LCD display screen and cell phone-inspired center console with cascading buttons. Come test drive the all-new Fiesta at Galpin Ford today. We love L.A.!
Categories 2011 Calendar Cars, G.A.S. Customs For Sale, Gallery Vehicle, Sedans, Vehicles


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Middle East recruiters expect new jobs in next 6 months
Naukrigulf survey reveals job creation and hiring much better in 2015 compared with 2014October 13, 2015 10:17
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MIDEAST STOCKS-Markets to rise on stronger global environment
Abu Dhabi's ADWEA in talks with banks for $350 mln project bond
Emirates hints at no Dubai Airshow orders, pushes decision on A350/787 to next year
UAE minister says plans to boost oil output capacity on track
MIDEAST STOCKS-Saudi, Egypt markets barely move in early trade
Qatar Q2 GDP growth accelerates to 4.8 pct year/year
UAE says reforms will better protect foreign workers
United Arab Bank secures $125 mln three-year loan
MIDEAST STOCKS-Saudi hit by weak oil, commodities; Egypt down modestly
MIDEAST STOCKS-UAE markets narrowly mixed in thin, early trade
Saudi Telecom Co saw its fourth-quarter net profit edge down 0.3 percent as foreign currency losses hit its annual income, but the operator still beat forecasts.
January 19, 2012 2:37 by Reuters
The former monopoly holder made a net profit of 2.28 billion riyals ($608 million), compared with 2.29 billion riyals a year earlier, it said in a statement posted on the bourse website.
It attributed a 19 percent decrease in net income for the 12-month period to 7.7 billion riyals "to foreign currency exchange fluctuation losses amounting to approximately 1.1 billion riyals".
Analysts polled by Reuters on average expected STC to post a quarterly profit of 1.93 billion riyals. STC's profit had missed estimates in three of the previous four quarters.
STC — which owns 35 percent of Turkey's Oger Telecom, has licences in Bahrain and Kuwait and a controlling stake in Indonesian firm Axis — said revenues were 15.2 billion riyals in the quarter, up from 13.4 billion riyals a year earlier.
The board recommended a 0.50 riyal per share dividend, resulting in a price to earnings ratio of 5.9 percent.
The standout performance for the company was in its wireless broadband services, where revenues more than doubled in the last three months of the year compared to the same period in 2010.
Fixed broadband customers grew by 28 percent on the year.
The operator's shares closed 0.3 percent lower on Saudi Arabia's bourse before the results were announced. ($1 = 3.7502 Saudi riyals) (Reporting By Angus McDowall; Editing by Firouz Sedarat)
Zain Saudi Arabia telcos Q4 loss narrows
January 19 2012
Saudi Arabia fears oil price spike on Iran tension
January 19 2012


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Greer Cabin Keepers
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Last day on the road
Finally a road meal to brag about. Great Navaho Taco - just the right spice and not greasy. My stomach says yummy. I forgot to mention the game bridges over the road. Open range again today. I saw sheep, deer, dogs, and drunk humans on the road. Passed Canyonlands and Arches National Parks. What fun Don, Jane, and I had there. Rain on and off all day. Sorry no pictures. Should get home tomorrow ...
Our work is done , We're leaving on a jet plane
It is said that when preparing to travel lay out all your clothes and all your money , then take half the clothes and twice the money!!
Our favorite thing to do is go places we've never been ! Thailand calls and we must go , Join us
as we explore.
Scenic highway 60
I enjoyed the scenery as we drove Highway 60 from Phoenix and Springerville. With our 60 ft. in length truck & RV. The highway goes through some mountains with great switchbacks. We had checked out the road on Google maps street level before deciding on the route. We had to make sure the curves weren't too tight & that Chuck could maneuver our rig around them.
There was one section of road, see picture, that ...
Crossing Another State Line
We left Santa Fe in the morning and headed towards the
Petrified Forest National Park. Went
along some of the old Route 66 where it was still in existence and passed
through some of the small towns that had been bypassed. Unfortunately there are no camping ...
Last Day at the Ranch/Payson Rodeo
... of any other horse so it was an easy ride for me. Ely, our wrangler, told us stories of other guests he had looked after in the last few months and how surprised he was when a Canadian mother and daughter arrived for a morning ride a little worse for wear or "hammed" as he put it, they could only just manage to stay upright in the saddle. The other was a German dad who fell asleep on top a horse.
After our ride we had to take a quick shower and load up the car so ...


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January 30, 2012
Charles Page, P. Geo., President and Chief Executive Officer of Queenston Mining Inc. is pleased to announce the appointment of Philip Ng, P. Eng. as Chief Operating Officer of the Company.
Having previously worked as Senior Vice President of Mining Operations for Claude Resources Inc., a gold producer with operations in Saskatchewan and Ontario, Philip provides Queenston the leadership in developing the Upper Beaver gold/copper deposit.
Mr. Ng has previously worked with major mining companies including INCO as Chief Mining Engineer at the Coleman McCreedy East Mine in Sudbury and was also employed by Hudson Bay Mining and Smelting as Rock Mechanic Specialist/Mine Planner to Mining Engineer.
Mr. Ng has a Bachelor of Engineering (B.Eng. Mining) and a degree in Masters of Engineering (M.Eng. Mining) from McGill University.
Queenston is a Canadian mineral exploration and development company with a primary focus on its holdings in the historic Kirkland Lake gold camp located in north-eastern Ontario. The objective of the Company is to advance the flagship, Upper Beaver project towards feasibility and production.
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In celebration of The Northern Miner's 100th anniversary in 2015, we will be sharing new pictures from our archives each week.
To submit a photo, visit the contact page and send it to one of our editors.
#TBT #Mining - St. Stephen Nickel Mines execs at the company's nickel-copper project in New Brunswick (1960). #TNM100 pic.twitter.com/i8YpFwC1vb— The Northern Miner (@northernminer) July 23, 2015
#TBT #Mining - St. Stephen Nickel Mines execs at the company's nickel-copper project in New Brunswick (1960). #TNM100 pic.twitter.com/i8YpFwC1vb


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Today's Love Horoscope
Seeing eye-to-eye with your partner on how to accomplish something important together won't come easily today. Try to compromise in order to keep the peace now!get your compatibility report
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THR's Idol Hangover: Episode 1
9:52 AM PST 3/2/2012 by THR Staff
The Hollywood Reporter's first live original talk show hosted by music editor Shirley Halperin and THR.com editor Joseph Kapsch features "American Idol" alumni guests, in-studio performances and Season 11 interviews.
The inaugural episode includes Season 6 runner-up Blake Lewis, Season 9 finalist and special THR's "Idol" correspondent Didi Benami and "Idol" expert Fred Bronson.
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'The Martian's' Matt Damon Talks 'Bourne' Return, Politics and PC Flubs: "Oh My God, I Look Like an Asshole"
The Insane Battle Over Sam Simon's Will — Should the Simpson's Co-Creator's Trust Pay $140,000 Per Year For One Dog's Care?
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Kirk Evans is a Microsoft Architect for the Azure Center of Excellence.
Introduction to SharePoint and Azure IaaS
Building SharePoint Apps with Windows Azure Platform as a Service
SharePoint Solutions and Architectures on Windows Azure Infrastructure Services
Understanding Authentication and Permissions with Apps for SharePoint and Office
From the DOTNET-WEB list on DevelopMentor:
Monday, September 8th, 2003
As part of Microsoft's attempts to make it easier for application developers to write secure code, Microsoft has added a new feature, named Request Validation, to the ASP.Net 1.1 framework. This feature is provides out of the box protection against Cross Site Scripting and Script Injection attacks, by automatically checking all parameters in the request and ensuring that their content does not include HTML tags.
WebCohort conducted research of this new ASP.Net feature, in order to determine whether it actually provides protection against Cross Site Scripting and Script Injection attacks or not.
The Findings:
The ASP.Net request validation feature has an implementation flaw, which allows an attacker to easily bypass the content restrictions, possibly exposing the application to Cross Site Scripting and Script Injection attacks.
Our research shows that the feature consists of banning all strings of the form <letter from the content of parameters. Hence the string "<script>", "<img" and even "<a>"are forbidden while strings like "</script>" are allowed. When the server encounters a forbidden string in the content of a parameter it issues an error message to the client.
As a result, WebCohort's Research Team was able to find a simple way to bypass the filtering mechanism. This is done by placing a NULL character between the less-then mark and the first character of the HTML Tag's name. Since this is no longer recognized by the request validation feature as a valid opening tag, it is ignored. However, many browsers, including Microsoft's IE 6.0 disregard NULL characters in their input.
Hence when the string in interpreted by the browser it is interpreted as an HTML tag, effectively yielding a Cross-Site Scripting (or Script
Injection) opportunity.
The exploit is done by simply adding a URL Encoded null character to the request sent to the server. For instance:
Version Tested:
ASP.Net 1.1
Do not rely on this feature for Cross-Site Scripting or Script Injection protection. The only effective method to avoid such attacks is performing HTML encoding within the application code itself.
Vendor Response:
Microsoft was approached on Thursday, August 21st, and acknowledged the problem the same day. According to Microsoft Security, an all-purpose (non security) software update, due to be released in a few weeks, will solve this problem. Since no preview of this update is currently available, the update has not been tested by WebCohort Research.


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At the North Platte Community College, Maxwell went 3-0 against Paxton, Eustis-Farnam and Stapleton-McPherson County.
After narrowly winning the first set 25-23, Paxton took the second 25-21. But in the end, the Wildcats persevered to win 25-18 and give the Lady Tigers its first loss at the NPCC Invite in recent memory.
In the final match, the Wildcats outlasted SMC (1-11) in three sets. The Cyclones won the first set 25-19 but Maxwell controlled the second 25-14 and won the third 26-24 to finish the day as the victors.
For the tournament, Maxwells Josie Cox had 32 kills and six stuff blocks.
Anna Crane had 24 kills, 32 digs and three ace serves.
Tracy Blake had 20 kills, 16 digs and two stuff blocks.
Kayla Stenger had 71 assists and two ace serves.
Naomi Schaub had 34 digs and two ace serves.
Bailee Keller had 17 digs and three ace serves.
Aura Adkisson had six ace serves, 9 kills and a stuff block; and Alex Gurciullo had four ace serves.
Flatrock Publishing, Inc.
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Thu 4th Jul at 8:30pm
Stewart Lee
@ Ye Olde Rose & Crown Theatre Pub, London
Also appearing: Susan Murray
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Never miss another 'Stewart Lee' show
Guffaw Comedy Club - Edinburgh Preview: Stewart Lee, Susan Murray
Image © (C)steve ullathorne, all rights reserved
Stewart Lee
An official Channel 4 survey of the 100 Greatest Stand-ups Ever placed Stewart Lee at number 41. His mother, whom he loves dearly, thinks Tom O'Connor the better comedian, having seen him do a joke about a sardine on a cruise ship ten years ago. And he isn't even in the top 100...
'The funniest, most cliche-free comedian on the circuit' (Ricky Gervais).
'Superlative... Remains one of the best stand-ups in the country' (Metro)
'Marvellously funny: mordant, thoughtful and crafted' (Observer)
'There's a wealth of evidence to suggest that in the last few years, Lee has gone completely mad' (The Guardian).
Stewart Lee tour dates
Susan Murray
Possibly one of the rudest women in the world today, and maybe also one of the funniest! winner of the first ever jongleurs competition and a seasoned regular on the circuit, Susan has emerged as one of the best female stand-ups around.
'She has the mentality of a spiteful 14 year old boy! Very admirable in a young lady!' (Arthur Smith)
'L like her jokes so much, I''m doing them now!' (Scott Capurro)
'Susan Murray's baffled everywoman persona cloaks a dry, intelligent wit' (Stewart Lee)
'... mainstream success written all over her... brightly energetic, a real talent' (Edinburgh Guide)
'... a right cheeky little lass who oscillates brilliantly and wildly between characters, accents, stories and banging the mike on her head' (Three Weeks).
Susan Murray tour dates
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Venue Facts
Venue: Ye Olde Rose & Crown Theatre Pub
53-55 Hoe Street
Website: yeolderoseandcrowntheatrepub.co.uk
Enquiries: 0208 509 3880
→ Walthamstow Central 6 min walk
→ Walthamstowe Central 7 min walk