text:
UAE: Biggest climber in visa index
Click here for the top 10 rankings in the regionOctober 8, 2015 6:09
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MIDEAST STOCKS-Markets to rise on stronger global environment
Abu Dhabi's ADWEA in talks with banks for $350 mln project bond
Emirates hints at no Dubai Airshow orders, pushes decision on A350/787 to next year
UAE minister says plans to boost oil output capacity on track
MIDEAST STOCKS-Saudi, Egypt markets barely move in early trade
Qatar Q2 GDP growth accelerates to 4.8 pct year/year
UAE says reforms will better protect foreign workers
United Arab Bank secures $125 mln three-year loan
MIDEAST STOCKS-Saudi hit by weak oil, commodities; Egypt down modestly
MIDEAST STOCKS-UAE markets narrowly mixed in thin, early trade
Blackberry's going to show off its goods to consumers across the UAE...will the PlayBook catch your fancy?
June 20, 2011 2:13 by kippreport
It's been touch and go for RIM over the past few months. Not only did RIM shares fall 21.5 percent last Friday on the New York Stock Exchange, the company's net profit fell 9.6 per cent to $695 million in Q1. And things are not looking too good: revenue for Q2 is expected to be between $4.2 billion and $4.8billion.
Things were looking much brighter in the beginning of the year. Although it has to be said that Blackberry is yet to release a major new and improved BB since its latest one in August.
But of course there is the BB Playbook, the launch of which was marred with some confusion about the date. There were earlier reports that the tablet's UAE launch would be delayed to June 25. In the end though, the company did deliver and the Playbook is readily available in a number of tech retailers across the country.
Stepping up efforts to stay in the game, RIM has just announced, to quote its press release, "it will be showcasing the new BlackBerry® PlayBook™ tablet in various mall locations across the UAE in June and July… PlayBook experience zones' will be available in the following locations from 22 June to 10 July: Marina Mall, Abu Dhabi, Abu Dhabi Mall, Mall of the Emirates, Dubai and Dubai Mall."
In the tech race, timing is everything isn't it? And only time will tell if the Playbook will make its way into the more hands across the UAE.
We know some of Kipp's readers are hard core BB-loyalists: in fact you are probably reading this on your own BB. So do you think that Blackberry is still relevant? And are you considering going the Playbook way?


text:
Locks And Locksmiths, Boulder, CO
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subset: commoncrawl


text:
|By Melih Oztalay
Article Rating:
|February 1, 2013 12:09 PM EST
Soave Enterprises invites residents and visitors of the master-planned Brambleton community to celebrate the spirit of giving this season by participating to win a new bike during the holidays.
Brambleton, VA – Soave Enterprises' award-winning master-planned community, Brambleton, announced the Spirit of Giving and Model Home Bike Giveaway Sweepstakes this week. Brambleton Town Center's newest tenant, Bicycle Outfitters, has teamed up with Brambleton to give away 19 bikes throughout November and December.
"We hope to inspire a spirit of giving within the community with this great sweepstakes and giveaway event," says Brambleton's marketing director. "Soave Enterprises has a long heritage of giving back to the community, and we are pleased to partner with Bicycle Outfitters this year to support our local families."
The Spirit of Giving Sweepstakes will run through the month of November to December 20, 2012. Events and giveaways will be held weekly and are as follows:
Week 1: November 12th
Two bicycles will be raffled off at the Brambleton Community Association's annual meeting (limited to Brambleton residents in attendance at the meeting only).
Week 2: November 19th
Facebook Contest – giveaway details will be posted on Brambleton's Facebook page.
Week 3: November 26th
Participants should save Brambleton Town Center receipts from Black Friday and Small Business Saturday. The two highest spenders during these days will win a bicycle.
Week 4: December 3rd
The "Give to Win" raffle will be hosted at the Brambleton Welcome Center. For each donation made in the Welcome Center from December 3, 2012 – December 8, 2012, to either the Friends of Homeless Animals wish list or the canned food drive, the donor will receive a raffle ticket for a chance to win one of two bikes.
Week 5: December 10th
Facebook contest – giveaway details will again be posted on the Brambleton Facebook page.
Week 6: December 17th:
Purchase a bike at Brambleton's Bicycle Outfitters from November 13, 2012 – December 19, 2012 to receive a raffle ticket for a chance to win a bicycle.
Model Home Bike Giveaway
Now through December 17, 2012, non-Brambleton residents who are shopping for a new home can enter for a chance to win a new bike when they visit any of the participating model homes within the Soave Enterprises community.
For restrictions, drawing dates, and more details on how to participate, visit Brambleton's Facebook page.
About Brambleton and Soave Enterprises
Every great plan starts with an idea, and that is how Brambleton began 10 years ago by Anthony Soave. Anthony Soave envisioned a community where residents could find the perfect balance of work, family, and life. This dream eventually became a reality when Brambleton broke ground. His vision and efforts put Soave Enterprises on the radar and the company was ranked number 251 on Forbes' largest privately held companies' list in 2010.
Soave Enterprises is a diversified management and investment company founded by Detroit businessman Anthony Soave that provides strategic planning, financial and other management resources to its affiliated business ventures. Soave Enterprises offers a diverse array of luxury real estate including beach-side condos in beautiful Naples, FL and the award-winning master-planned Brambleton community in Virginia. For more information on Tony Soave and Soave Enterprises, please visit http://www.soave.com.
Soave Enterprises
3400 E Lafayette
Detroit, MI 48207
The post Soave Community Hosts Holiday Bike Giveaway Event appeared first on SmartFinds Internet Marketing.
Read the original blog entry...
As enterprises capture more and more data of all types – structured, semi-structured, and unstructured – data discovery requirements for business intelligence (BI), Big Data, and predictive analytics initiatives grow more complex. A company's ability to become data-driven and compete on analytics depends on the speed with which it can provision their analytics applications with all relevant information. The task of finding data has traditionally resided with IT, but now organizations increasingly turn towards data source discovery tools to find the right data, in context, for business users, d...
Oct. 4, 2015 10:00 PM EDT Reads: 368
"The Internet of Things transforms the way organizations leverage machine data and gain insights from it," noted Splunk's CTO Snehal Antani, as Splunk announced accelerated momentum in Industrial Data and the IoT. The trend is driven by Splunk's continued investment in its products and partner ecosystem as well as the creativity of customers and the flexibility to deploy Splunk IoT solutions as software, cloud services or in a hybrid environment. Customers are using Splunk® solutions to collect and correlate data from control systems, sensors, mobile devices and IT systems for a variety of Ind...
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Apps and devices shouldn't stop working when there's limited or no network connectivity. Learn how to bring data stored in a cloud database to the edge of the network (and back again) whenever an Internet connection is available. In his session at 17th Cloud Expo, Bradley Holt, Developer Advocate at IBM Cloud Data Services, will demonstrate techniques for replicating cloud databases with devices in order to build offline-first mobile or Internet of Things (IoT) apps that can provide a better, faster user experience, both offline and online. The focus of this talk will be on IBM Cloudant, Apa...
Oct. 4, 2015 08:00 PM EDT Reads: 357
Clearly the way forward is to move to cloud be it bare metal, VMs or containers. One aspect of the current public clouds that is slowing this cloud migration is cloud lock-in. Every cloud vendor is trying to make it very difficult to move out once a customer has chosen their cloud. In his session at 17th Cloud Expo, Naveen Nimmu, CEO of Clouber, Inc., will advocate that making the inter-cloud migration as simple as changing airlines would help the entire industry to quickly adopt the cloud without worrying about any lock-in fears. In fact by having standard APIs for IaaS would help PaaS expl...
Oct. 4, 2015 02:30 PM EDT Reads: 388
Organizations already struggle with the simple collection of data resulting from the proliferation of IoT, lacking the right infrastructure to manage it. They can't only rely on the cloud to collect and utilize this data because many applications still require dedicated infrastructure for security, redundancy, performance, etc. In his session at 17th Cloud Expo, Emil Sayegh, CEO of Codero Hosting, will discuss how in order to resolve the inherent issues, companies need to combine dedicated and cloud solutions through hybrid hosting – a sustainable solution for the data required to manage I...
Oct. 4, 2015 02:00 PM EDT Reads: 401
SYS-CON Events announced today that IBM Cloud Data Services has been named "Bronze Sponsor" of SYS-CON's 17th Cloud Expo, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. IBM Cloud Data Services offers a portfolio of integrated, best-of-breed cloud data services for developers focused on mobile computing and analytics use cases.
Oct. 4, 2015 01:00 PM EDT Reads: 550
SYS-CON Events announced today that ProfitBricks, the provider of painless cloud infrastructure, will exhibit at SYS-CON's 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. ProfitBricks is the IaaS provider that offers a painless cloud experience for all IT users, with no learning curve. ProfitBricks boasts flexible cloud servers and networking, an integrated Data Center Designer tool for visual control over the cloud and the best price/performance value available. ProfitBricks was named one of the coolest Clo...
Oct. 4, 2015 01:00 PM EDT Reads: 709
Learn how IoT, cloud, social networks and last but not least, humans, can be integrated into a seamless integration of cooperative organisms both cybernetic and biological. This has been enabled by recent advances in IoT device capabilities, messaging frameworks, presence and collaboration services, where devices can share information and make independent and human assisted decisions based upon social status from other entities. In his session at @ThingsExpo, Michael Heydt, founder of Seamless Thingies, will discuss and demonstrate how devices and humans can be integrated from a simple clust...
Oct. 4, 2015 12:00 PM EDT Reads: 613
As more and more data is generated from a variety of connected devices, the need to get insights from this data and predict future behavior and trends is increasingly essential for businesses. Real-time stream processing is needed in a variety of different industries such as Manufacturing, Oil and Gas, Automobile, Finance, Online Retail, Smart Grids, and Healthcare. Azure Stream Analytics is a fully managed distributed stream computation service that provides low latency, scalable processing of streaming data in the cloud with an enterprise grade SLA. It features built-in integration with Azur...
Oct. 4, 2015 11:00 AM EDT Reads: 716
You have your devices and your data, but what about the rest of your Internet of Things story? Two popular classes of technologies that nicely handle the Big Data analytics for Internet of Things are Apache Hadoop and NoSQL. Hadoop is designed for parallelizing analytical work across many servers and is ideal for the massive data volumes you create with IoT devices. NoSQL databases such as Apache HBase are ideal for storing and retrieving IoT data as "time series data."
Oct. 4, 2015 10:45 AM EDT Reads: 398
SYS-CON Events announced today that HPM Networks will exhibit at the 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. For 20 years, HPM Networks has been integrating technology solutions that solve complex business challenges. HPM Networks has designed solutions for both SMB and enterprise customers throughout the San Francisco Bay Area.
Oct. 4, 2015 09:00 AM EDT Reads: 547
Mobile messaging has been a popular communication channel for more than 20 years. Finnish engineer Matti Makkonen invented the idea for SMS (Short Message Service) in 1984, making his vision a reality on December 3, 1992 by sending the first message ("Happy Christmas") from a PC to a cell phone. Since then, the technology has evolved immensely, from both a technology standpoint, and in our everyday uses for it. Originally used for person-to-person (P2P) communication, i.e., Sally sends a text message to Betty – mobile messaging now offers tremendous value to businesses for customer and empl...
Oct. 4, 2015 08:30 AM EDT Reads: 154
SYS-CON Events announced today that MobiDev, a software development company, will exhibit at the 17th International Cloud Expo®, which will take place November 3-5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. MobiDev is a software development company with representative offices in Atlanta (US), Sheffield (UK) and Würzburg (Germany); and development centers in Ukraine. Since 2009 it has grown from a small group of passionate engineers and business managers to a full-scale mobile software company with over 150 developers, designers, quality assurance engineers, project manage...
Oct. 4, 2015 04:00 AM EDT Reads: 666
The broad selection of hardware, the rapid evolution of operating systems and the time-to-market for mobile apps has been so rapid that new challenges for developers and engineers arise every day. Security, testing, hosting, and other metrics have to be considered through the process. In his session at Big Data Expo, Walter Maguire, Chief Field Technologist, HP Big Data Group, at Hewlett-Packard, will discuss the challenges faced by developers and a composite Big Data applications builder, focusing on how to help solve the problems that developers are continuously battling.
Oct. 4, 2015 04:00 AM EDT Reads: 328
SYS-CON Events announced today that Cloud Raxak has been named "Media & Session Sponsor" of SYS-CON's 17th Cloud Expo, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. Raxak Protect automates security compliance across private and public clouds. Using the SaaS tool or managed service, developers can deploy cloud apps quickly, cost-effectively, and without error.
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Who are you? How do you introduce yourself? Do you use a name, or do you greet a friend by the last four digits of his social security number? Assuming you don't, why are we content to associate our identity with 10 random digits assigned by our phone company? Identity is an issue that affects everyone, but as individuals we don't spend a lot of time thinking about it. In his session at @ThingsExpo, Ben Klang, Founder & President of Mojo Lingo, will discuss the impact of technology on identity. Should we federate, or not? How should identity be secured? Who owns the identity? How is identity ...
Oct. 3, 2015 11:00 AM EDT Reads: 404
SYS-CON Events announced today that Solgeniakhela will exhibit at SYS-CON's 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. Solgeniakhela is the global market leader in Cloud Collaboration and Cloud Infrastructure software solutions. Designed to "Bridge the Gap" between Personal and Professional Social, Mobile and Cloud user experiences, our solutions help large and medium-sized organizations dramatically improve productivity, reduce collaboration costs, and increase the overall enterprise value by bringing ...
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Sensors and effectors of IoT are solving problems in new ways, but small businesses have been slow to join the quantified world. They'll need information from IoT using applications as varied as the businesses themselves. In his session at @ThingsExpo, Roger Meike, Distinguished Engineer, Director of Technology Innovation at Intuit, will show how IoT manufacturers can use open standards, public APIs and custom apps to enable the Quantified Small Business. He will use a Raspberry Pi to connect sensors to web services, and cloud integration to connect accounting and data, providing a Bluetooth...
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SYS-CON Events announced today that Micron Technology, Inc., a global leader in advanced semiconductor systems, will exhibit at the 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. Micron's broad portfolio of high-performance memory technologies – including DRAM, NAND and NOR Flash – is the basis for solid state drives, modules, multichip packages and other system solutions. Backed by more than 35 years of technology leadership, Micron's memory solutions enable the world's most innovative computing, consumer,...
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Asheville-Buncombe Technical
Community College's Craft Beverage Institute has
received a grant from Duke Energy to expand its craft beverage program.
The Asheville Citizen-Times reports (http://avlne.ws/1kJem2r) the school's Craft Beverage Institute is getting a $195,000 grant that will buy a 7-10-barrel brew house, a canning machine, a distillation system and a micro winery.
Program director Scott Adams says the equipment should be on the Enka campus by fall.
Adams said two dozen students are now in the program, and another two dozen will begin in August. He said some students have traveled to the school from as far as Oregon.
A-B Tech would eventually like to open a tasting facility similar to what's offered by Surry Community College's wine program in Dobson. Brewmaster Jeff Irvin said that would involve a change in state law.
10/2/2015Decreasing The Skills Gap
9/23/2015Case Study: Regional Collaboration of Rural Community Colleges
9/14/2015Two Changes
9/16/2015 » 12/18/2015Fall 2015 - NACCE's Entrepreneurship Specialist Certificate Online Training
10/11/2015 » 10/14/2015NACCE 2015 Conference - Register Now!
10/29/2015Monthly NACCE Membership Webinar- NACCE2015 Recap
10/8/2016 » 10/12/2016Save-the-date for #NACCE2016!


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Wasurenosato Gajyoen
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
TripAdvisor Reviews Wasurenosato Gajyoen Kirishima
Travel Blogs from Kirishima
History of Satsuma
... It just very hard to understand if you do not speak and understand Japanese.... well , maybe its just me...... It Seems to me that the Japanese just have no interest to be understood and will further Isolate them if they are not Changing their Education system to adopt a second world language for coming Generations. The do make it up by being very very Friendly and courteous and trying hard to accommodate everybody..... but very few even speak a few words of a foreign ...
More bureaucratic nonsense
... the old 1048 Convention based License!!!!! Not being easily discouraged went to an JAF Office to have my current License Translated to fulfill their Requirements.....only took a half a day and 3000 Yen..... It's all relative and overall actually a great opportunity to learn more about Japanese ...
Pencil-Pushers @ JCAA
... have to deal with those Idiotic Pencil Pushers but there is no way around them since those are the People which Issuing Flight permits. on top of all that they need 10 day's Lead-time to approve a private Flight from Point A to Point B and ones this permit is Issued they have absolutely no flexibility on any concern which affect GA operation like Weather considerations. It can be ...
Kagoshima Weather
... time it should be Test Flown before taken for a longer Flight and my SX was stored for tow Months here and my next Destination is 1000 miles to the North , therefore I have to take changes taking a Fully Loaded Airplane full of Fuel and if there is a problem on the first take off the only Option is turning around and Landing an Overweight Airplane and if something goes wrong then of course it is never those stupid rules , it would be "Pilot error" in the Japanese JCAA bureaucratic ...
Day 15-18:Visiting my dad, his wife and my sister!
... the world!!! Hiroko-san was very nervous about how Miki would react. However, when she did, Miki was certainly shocked but she took it very well. Which is a wonderful reminder that sometimes we worry too much about how someone may react to finding out about things and oftentimes - yes, not always - it all works out for the better.
So finally back to this trip. We left Kagoshima and took the train to Yamakawa station where we were going ...
Other places to stay in Kirishima
Kirishima HotelKirishima Onsen, Kirishima | Hotelfrom $151
Hotel Kyocera1409-1 Mitsugi Hayato-cho , Kirishima | Hotelfrom $76
Kirishima Kanko HotelKirishima Onsen, Kirishima | Hotelfrom $107
Kirishima Kokusai HotelKirishima Onsen, Kirishima | Hotelfrom $131
Kirishima Iwasaki HotelKirishima Onsen, Kirishima | Hotelfrom $103
Kagoshima Kuko Hotel616-1 Fumoto Mizobe-cho, Kirishima | Hotelfrom $93
Sun Hotel Kokubu3-24-31 Kokubuchuo, Kirishima | Hotelfrom $62
Kirishima Sanjo HotelKirishima Onsen, Kirishima | Hotelfrom $95
Kirishima Daiichi Hotel Spa-HillsKirishima Onsen, Kirishima | Hotelfrom $96
Yuyuan1-177 Hayato-cho Himegi, Kirishima | Hotelfrom $165
Urban Hotel Kokubu3-17-19 Kokubuchuo, Kirishima | Hotelfrom $59
Station Hotel Hayato1-5-8 Hayato-cho Uchiyamada, Kirishima | Hotelfrom $36
Travelodge Scotch Corner A1 SouthboundMoto Service Area, Scotch Corner | Hotelfrom $38


text:
Lengthy looped synth sequence I made using synth sequencer with regard to space dawn.
Cartoon Hillbilly character saying "Are you 100% sure about that?" recorded with camcorder.
Silly mocking voice
tempo 130 key Gm
tempo 130 key Gm
This sound belongs to a sample pack that contains all the sounds I used to make my Vietnam mix. (I'll ...
Alternate version of the words, "Now it's time for some dubstep."
recorded on my camcorder, opened in power director, dropped video, adjusted audio with reverb and speed a little then saved ...
please use n enjoy... praise Buddha :D
Steady change between minor and major broken chords is slowly transformed by layering different timbres and colours. The sound may ...
This is an extended all-in-one sketch that contains two movements (calmer and hotter) and a pack of guitar "spice" in ...
Synth sequence phrase loop made in FL studio looking for space synth or synth pop feeling. Harmor synth.
The intro comment, "Wha's that I hear a little aromatic bigbeat?"
A basic sample of the words, "You are in the mix with DJ Dronko."
Short welcoming by evil cartoon character plus laugh.


text:
Tu Casa is a cozy and friendly hostel in Saude's neighborhood (south of Sao Paulo). Known for its safety, this... More Info »
We are a small, 23 bed Hostel close to Avenida Paulista in Sao Paulo. The Mama offeres a unique mix of peacefulness... More Info »
Property Information: Near Paraiso metro station and less than 15 minutes walk to Paulista Avenue, Aquarela SP is... More Info »
We're in the heart of Vila Madalena, the famous neighborhood of gastronomy, arts, and bohemian nightlife in the city... More Info »
A few words first. The best location a hostel can have in town. Free Internet and Wi-Fi. Great staff in a fun... More Info »
Perfect location & really clean! Prices Included: great breakfast, internet, wi-fi, towel, lines and other amenities.... More Info »
Stay at one of the largest hostels in Brazil! We offer a unique social area where you can have lot of fun and in a... More Info »
The rhythm of the largest metropole on the southern hemisphere. That's what you will find at Beats Hostel. Extra... More Info »
A two minutes walk from Vila Madalena subway station and bus terminal, takes you to Hostel Alice. Located at Vila... More Info »
Since 2007 one of the most traditional hostels in SP. We are located in Vila Madalena, known for its zillion... More Info »
About São Paulo Global Hostel As travellers ourselves, we compiled all of our experiences to build a place where... More Info »
The guests will find more than a really good hostel structure, they will also find that cozy home sweet home feeling,... More Info »
Cafe Hostel, conceived when two friends who travelled five continents decided to create a hostel with the best they... More Info »
Imagine a group of friends, crazy by breaking the world, meet different people and live unusual situations. Friends... More Info »
Tranqüilidade, ambiente familiar, excelente localização, ótimo custo beneficio. São muitas das palavras que descrevem... More Info »
HI Praça da Arvore gives the best hostel service in the heart of São Paulo and has rooms for 2, 4, or 8 people... More Info »
The Hostel is fitted with wood floors and bed frames the room offers access to a shared bathroom. We are based in... More Info »
Pamplona Hostel is just about a five-minute walk to Trianon-MASP (underground station) at Avenida Paulista), the most... More Info »
The Hostel Vila Mariana is the place where past and present are together. A beautiful building with amazing views.... More Info »
Video guides, travel podcasts, city maps & free city guides. What to eat, where to stay and things to do and see - our travel guides have it all.Find a guide »
The epitome of culinary richness, Marrakesh -the heart of the red city, is a foodies wonderlandRead more »
We offer the most comprehensive selection of hostels on the internet with over 35,000 great places to stay in 180 countries. The ultimate online resource for hostels everywhere.Find great value hostels »


text:
Rutherford Hotel Nelson
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
- Suites
- Minbar in room
- High-speed internet in room (surcharge)
- Room service
- Wireless internet connection in room (surcharge)
- Swimming pool
Travelers also recommend:
TripAdvisor Reviews Rutherford Hotel Nelson
Travel Blogs from Nelson
Heading North with vicious biting midges!
... a lot of concentration so please do not chat to me but feel free to watch' – opps!
We managed to find a cheap campground (�8 a night) on the edge of town in the Maitai Valley, so at that price we decided to book in for two nights to give us a full day to explore the area.
After breakfast, we set off for the hour long walk that would end up in the centre of Nelson. We ...
Southward Bound
... another bus but both were going to the same place, so no problems there. I sat by Georgina and we discussed all about Queenstown, as she's going to live and work there. In fact her friend she lives with knows Tom and Nath, the guys from Dursley who live there. Again, small world. It was quite a straight forward drive to our next stop Kaiteriteri. It was a very scenic beach town which translates to Fast fast food in English. Apparently this is ...
... It has 3 national parks all within 90 minutes from Nelson city centre. It is known for is coastal towns. It also has the countries highest number of sunshine hours. Port Nelson is also the largest port in Australasia. Oh.. And how can we forget, the first ever recorded rugby game was played in Nelson on Saturday 14 May, 1870. Between Nelson club team and Nelson ...
Walk - No Boat
... was negotiated o.k. although the path was narrow in places. Hardly wide enough for two worldly goods rucksacks to pass. We were also overtaken by a young girl, that I placed in the " free spirit " class wearing a bikini, flip flops and carrying her hand bag. This caused me some moments of diversionary entertainment. My suggestion we speed up a bit got no response. Suffice to say that the scenery along the walk was fantastic and we arrived at ...
Nelson and Wellington
... we filled up with petrol. It already costs the equivalent of 90p a litre and he managed to save an extra 5p!
Nelson Airport is very small....and so are he planes.
It will only take us 20 minutes to fly to Wellington. It took nearly 4 hours to get here on the ferry from North Island on our way here. So it is goodbye South Island. We have really enjoyed our time here..and we have seen some wondrous ...


text:
Turisol Benisa
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
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Travel Blogs from Spain
How to sleep on a plane
... cabin crew to prod you, trying to find out whether you're buckled up. Keeping your seatbelt visible above your clothes before take off will prevent this.
Be in no mood to chat Politely deter your neighbour from engaging in mid-flight small talk by waving a book around, plugging in headphones, or muttering to yourself in an obscure foreign language.
Don't drink too much While the soporific effects of booze ...
Comedy Central
... their phones, but we couldn't figure out where they were. So the 3 of us decided to get in line at the municipal albergue since we didn't have a reservation set up for that night and we would need a place to stay. We were on the edge of being 120th in line and there were only 120 spots in the municipal. We waited there in the hope that someone counted wrong and we might still get in. We waited in line for about 2 1/2 hours before we were really curious where ...
3 Weeks on the beach..fun n sun ..lots of Hot sun
Arrived at our destination, Altea on Saturday July 4. Stayed the first 4 nights with Percy , Simons buddy from school days, and his very gracious wife, Begonia. Their apt is located one block from the beach front. It has been kind of like summer camp. They have kept us entertained with home cooking, swimming, kayaking, picnics, sidewalk tapas, One evening we all went for an incredibly beautiful hike up the mountain to the lighthouse . Ending the evening at a restaurant on ...
Salem climbing
Heading north to Valencia we stopped off in Rugat which is close to the climbing areas of Salem and Gandia.
Thankfully Salem has a number of walls which face East and North so we managed to get a full days climbing in and be in tne shade most of the day. Gandia was not quite so shady but we did manage a couple of hours in ...
First day in Barcelona
... of the city taking in the main part of the city, the old section, a bit of the harbour and thru some of the shopping precincts. We don't hop off but stay on and earmark sections for another days visit on foot. I certainly get lots of photos as we drive past places ( some just of trees but them are the breaks. ) Definetly want to walk thru the Barri Gotic area ( the oldest part of Barcelona)
Being quiet warm when we arrive back at The Placa D'Espanya we decide to stop ...


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JAMES in AL
if you can afford them buy them. riding with anything less is not my idea of being smart. think about it, flexing, rubbing, landing, stem movement, dirt, water, errosion, need i go on?Read All Reviews
Jake in Arizona
Only tubes i use and recommend. Nothing worse than being stuck with a flat on the trail. Little more difficult to install but 100% worth it.Read All Reviews
CHRIS in WA
No problems at all. Landing on rocks different air pressures riding like a mad man. It will take it.Read All Reviews


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Internet Software and Services
Company Overview of Buzzsaw.com, Inc.
Company Overview
As of August 20, 2001, Buzzsaw.com, Inc. was acquired by Autodesk, Inc. Buzzsaw.com, Inc. provides online collaboration applications for the building industry in the United States. It offers online collaboration, printing, and procurement services that connect project teams throughout the design, construction, and property management process.
235 Montgomery Street
5th Floor
San Francisco, CA 94104
United States
Founded in 1999
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Buzzsaw.com, Inc. does not have any Key Executives recorded.
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Buy houses in Creighton Avenue, London N10 - 1 bedroom
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Guide price* £380,000
Flat 2, 35 Kings Avenue, Muswell Hill N10Property for sale - 1 bedrooms
Lot 202 - This lot is for sale by auction as lot 202 on 17th September 2015. A Leasehold Self-Contained Ground Floor Flat. Share of Rear Garden Tenure Leasehold. The property is held on a lease for a term of 99 years from 25th March 1984 (thus having ... More details
Note: Distances are straight line measurements
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Marketed by Allsop LLP, W1U. Call 020 3641 1750


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by Ari Phillips Jul 30, 2015
The prescription: less coal, curb natural gas growth, and focus aggressively on renewables and energy efficiency.
by Ryan Koronowski Jul 20, 2015
The broken records inside the 2014 State of the Climate report.
by Natasha Geiling Jun 13, 2015
A new study's findings are in contrast to a common conservative argument that more CO2 in the atmosphere will be good for plants.
by Ari Phillips May 15, 2015
When China's greenhouse gas emissions fall, they fall hard.
by Ari Phillips May 6, 2015
New figures show that March was the first month ever to globally exceed 400 ppm in atmospheric carbon dioxide levels every day.
by Emily Atkin Apr 9, 2015
As of now, it's unclear whether Japan's reported pledge is actually significant.
by Katie Valentine Mar 5, 2015
Accounting for the social costs of burning gasoline would add an average of $3.80 per gallon to the pump price, a study has found.
by Katie Valentine Feb 26, 2015
If countries made a point of reducing their food waste, the globe could save a total of $120 to $300 billion each year by 2030, according to a new report.
by Ari Phillips Feb 4, 2015
On Wednesday, a Chinese government official said that China plans to launch the first stages of a national carbon market next year.
by Emily Atkin Jan 13, 2015
The average amount of carbon dioxide in our atmosphere has been above 400 parts per million since the beginning of 2015.


text:
ConnectingSingles is a 100% free Maine dating site for singles in Maine and worldwide.
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Theres A Sign On The Side Of The Highway And it Says Keep Your Eyes On The Road Now How are We Supposed To Do ... ......
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OSPF - Open Shortest Path First
Short for Open Shortest Path First, an interior gateway routing protocol developed for IP networks based on the shortest path first or link-state algorithm.
Routers use link-state algorithms to send routing information to all nodes in an internetwork by calculating the shortest path to each node based on a topography of the Internet constructed by each node. Each router sends that portion of the routing table (keeps track of routes to particular network destinations) that describes the state of its own links, and it also sends the complete routing structure (topography).
The advantage of shortest path first algorithms is that they results in smaller more frequent updates everywhere. They converge quickly, thus preventing such problems as routing loops and Count-to-Infinity (when routers continuously increment the hop count to a particular network). This makes for a stable network.
The disadvantage of shortest path first algorithms is that they require a lot of CPU power and memory. In the end, the advantages out weigh the disadvantages.
OSPF Version 2 is defined in RFC1583. It is rapidly replacing RIP on the Internet.
Stay up to date on the latest developments in Internet terminology with a free weekly newsletter from Webopedia. Join to subscribe now.
From wacky alarm clocks to lecture hall tools and after class entertainment, these Android apps are a good fit for a student's life and budget. Read More »Sharing Threat Intelligence
A growing number of startups make the sharing of threat intelligence a key part of their solutions. Read More »Smiley Faces and Symbols
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Networking fundamentals teaches the building blocks of modern network design. Learn different types of networks, concepts, architecture and... Read More »Computer Architecture Study Guide
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All year long, dozens of young chefs from across New York City have been perfecting their chopping techniques, learning the difference between cumin and cayenne, tasting an endless stream of vegetables and fruit, all in pursuit of the perfect recipe for their year-end Iron Go!Chefs competition.
Jesse Owens was the first American track and field athlete to win four gold medals, during the 1936 Olympics in Berlin. Today, he's widely considered the greatest track and field athlete in history. Yet, he also faced many challenges, and his highs and lows are explored in a recently unveiled mural at the Dunlevy Milbank Center in Harlem.
Fannie Lou Hamer Freedom High School in the Bronx has been racking up honors and awards this spring, but none have drawn as much attention as its Schools of Opportunity Gold Recognition.
On Tuesday, June 9, the School Age Division held its third annual word bee at the Dunlevy Milbank Center. Over the course of the year, young people in grades K-2 learned 25 new words, parts of speech, and definitions through engaging activities. In grades 3-8, students learned 50 new words, parts of speech, and definitions. Competitions began in May to crown site champions, and those winners came to test their skills and knowledge at Milbank.
On Saturday, June 13, about 60 volunteers from Citi descended upon Wagon Road Camp in Westchester County for a long day of service to help get the site ready for summer. In just a few weeks, Wagon Road will be the destination for hundreds of kids, many of them from New York City getting a chance to experience new outdoor adventures while staying engaged with learning opportunities.
Colorful paintings, expressive masks, and street photography covered the walls of the Boricua College Art Gallery in Washington Heights at the 14th Annual Children's Art Show. The many pieces of art on display came from all corners of the Children's Aid community, with artists starting as young as our Head Start participants—three and four years old—to our graduating high school seniors.
When Warwick Valley High School student Ally Ehrmann was told that her senior project had to have a tangible outcome, she decided to raise money for a cause close to her heart. That cause ended up being young people in foster care.
City Council Speaker Melissa Mark-Viverito said that she started working on the garden that opened this week at P.S. 50 in East Harlem when she was in her first term on City Council. Today, she's in her third term.
Herbert Godoy and David Hatcher had been thinking for some time about how they were going to start their family. They knew they were going to adopt but didn't know which of several routes to take. Then they saw a picture of Jaylen.
711 Third Avenue - Suite 700 | New York, NY 10017 | 212-949-4800 | 212-949-4936 (Development)
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Hotel Akti
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We had our last dinner in another classic Greek taverna, usual grub. The bigger children went off to party whilst the oldies and younger ones tried to sleep. Not very pleased with certain children who were a bit noisy on their return. Richard is going to spend the rest of his life in the ...
Last day
Skipper up bright and early a better nights sleep although a bit of swell. Sam had the bright idea of trying to rig up springs on the back of the boat to ease the motion. This was a good plan and I think made the situation better. It is now 09:00 and nobody apart from skipper is up. They will be soon The plan for the day is to take the children Halyard Jumping and have a bit of a sail for our last day. Then back to our home port for ...
... Sadly as it was getting dark the port police were not happy and we had to move!! I am happy to say that this was a move to park on the main quay with power and water. So happy. However. We had to get there. Sam and I were dispatched to do the parking. Neither of us were quite sure where to go in the dark!! However we managed to work out our course (backwards) and started our approach. Between the two of us with the flotilla lead on shore we managed to to a perfect ...
An interesting few days
... up Claire and fixed a back slab to Richard's broken wrist.
The hospital itself was far from 20th century for example no soap in toilets. Very few supplies, needles and blood on the floor. However return we did for x-Rays the following morning.
So. In the morning we returned. No power so no x-Rays. Nobody would give us drugs. And we could not get them ...
Busy couple of days
... town!!! We arrived around 16:30 and headed off for food shopping to make sure that 4 boys have enough to eat!! Whilst the adults were doing sensible things two bad children had a float around in the tender. This is a busy harbour with Greek captains who would think nothing of running over two young people. More time in the naughty tender...... We had a pre-booked restaurant which our flotilla host Ellie had booked. Another Greek meal!! Was fun and went on for a while. Then ...


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Some key moments in the history of British Handball from an article by Joshua Drake published in 2013.
Thursday, 2 April 2015
Monday, 10 November 2014
Handball on TV
The 2012 Olympics were not the first occasion that handball had featured on domestic TV in the UK. As far back as the 1970s the sport was featured on the Saturday afternoon sports programmes Grandstand (BBC1) and World of Sport (ITV). In this cutting from the Guardian of 21 February 1976 the TV schedule shows a handball international between Great Britain and Poland is listed as starting at 1 o'clock. However, the feature was a short one with the News listed as starting at 1.10!
The match was played at Picketts Lock Sports Centre with the result Great Britain 11 - Poland 55.
The match was played at Picketts Lock Sports Centre with the result Great Britain 11 - Poland 55.
Posted by Russell Hadd at 06:19 No comments:
Saturday, 27 July 2013
GLSE Select's first ever game in 1981
In celebration of GD playing Ruislip in the Copper Box one year on from the Olympics, this post shows a very brief report of the first game played by the GLSE Select team on Saturday 30 May 1981. The team took on a visiting Swiss police team and went down by 34-17. The team line up shows four players from Ruislip Eagles and three from Great Dane. The report appeared in the first edition of the GLSE Handball News in October 1981 on page 13.
Posted by Russell Hadd at 15:06 No comments:
Saturday, 29 June 2013
Cardinal Griffin School
Today is the school national finals for handball and one team taking part with a long tradition is the Cardinal Griffin School in Cannock. This photograph shows a press photograph from the under 15 final in 1982 when Cardinal Griffin defeated Woughton Campus 18-11.Teramo Tournament in Italy which was then the European Under-14 Championships in all but name.
Posted by Russell Hadd at 07:15 No comments:
Saturday, 15 June 2013
1970s Scottish Action
This photo by Arthur Kinloch appeared in the Glasgow Herald on 11 December 1979. It shows Billy Hayburn (centre with the ball), who then played for Allander and Scotland U21, and two unnamed defenders.
|Billy Hayburn
Posted by Russell Hadd at 13:31 No comments:
Tuesday, 28 May 2013
The Hull Handball League (Part 5)
This photograph appeared in the Hull Daily Mail along with a short interview with Ron Lister. It shows the presentations at the Hull Handball Association Dance in the early '60s which was held at the Beverley Baths.
In the interview Mr Lister explained that football referees had been recruited to learn the rules of handball and officiate in the league which took place over the summer. It was felt that it was an ideal sport for football and rugby players to play in the closed season.
As in a previous Hull Daily Mail article, Mr Lister goes on to explain that the first international to be played by Great Britain was against Holland in 1959 and that this was followed up a year later by an international against Germany. However, this report gives further details, in that it confirms that the Germany international was also played in Hull at the Costello Stadium which is now the KC Stadium.
Posted by Russell Hadd at 02:53 No comments:
Tuesday, 5 February 2013
Scotland - England Internationals
This is a short report from the Glasgow Herald of Monday 6 May 1985 about the Scotland versus England Handball internationals which had taken place on the weekend before.
Posted by Russell Hadd at 12:49 No comments:
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for more info, please see events page here.
Currently on Exhibit:
Eric Schnell: Binder
On view through October 4th
More information can be found at www.ericschnellstudio.com
Volunteering is a great way to meet other art enthusiests and, in many cases, get FREE admission to classes, festivals and invitation-only parties. A Galveston Arts Center staf member will contact you by the following business day to confirm your committement, fill you in on the details, and answer any questions.
Annual Fund
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BBB Accredited Business since 11/19/2001
SkyValley Landscape, Inc.
(520) 571-6959View Additional Phone Numbers9143 Moenkopi Trail, Tucson, AZ 85749www.skyvalleylandscape.com
BBB Business Reviews may not be reproduced for sales or promotional purposes.
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BBB Accreditation
A BBB Accredited Business since 11/19/2001
BBB has determined that SkyValley Landscape, Inc. meets BBB accreditation standards, which include a commitment to make a good faith effort to resolve any consumer complaints. BBB Accredited Businesses pay a fee for accreditation review/monitoring and for support of BBB services to the public.
BBB accreditation does not mean that the business' products or services have been evaluated or endorsed by BBB, or that BBB has made a determination as to the business' product quality or competency in performing services.
Reason for Rating
BBB rating is based on 13 factors. Get the details about the factors considered.
Factors that raised SkyValley Landscape, Inc.'s rating include:
- Length of time business has been operating.
- No complaints filed with BBB.
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Licensing, Bonding or Registration
This company is in an industry that may require licensing, bonding or registration in order to lawfully do business. BBB encourages you to check with the appropriate agency to be certain any requirements are currently being met.
These agencies may include:Arizona Registrar of Contractors
400 W Congress St STE 212
Tucson, AZ 85701
(520) 628-6345
BBB records show a license number of 151349 for this company, issued by Arizona Registrar of Contractors. Their web address is http://www.azroc.gov. The expiration date of this license is 01/31/2016.Type: Contractors
Check License Status: http://www.azroc.gov/forms/details.asp?license=151349
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Incorporated: December 1999, AZ
Contact InformationPrincipal: Mr. Ted Essig (President)Ms. Tina Essig (Vice President)
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Landscape Architects, Landscape Lighting, Landscape Contractors, Irrigation Systems - Install/Design, Outdoor Kitchens


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Men's Golf
Jerry Pate Intercollegiate
Tue., Oct 8
Vestavia Hills, AL
Old Overton Country Club
Old Overton Country Club
Vestavia Hills, AL
Watch Info
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More: Jerry Pate Intercollegiate - Men's Golf
Wildcats Wrap Up Day One of William H. Tucker Invitational
Wildcats compete in day one of the William H. Tucker Invitational
Arizona Travels to Albuquerque for William H. Tucker
Nine Wildcat golfers are headed to New Mexico to compete at the UNM Championship Course.
Wildcats Place Eighth at the Saint Mary's Invitational
Sophomore Jordan Gumberg ties for ninth at the Saint Mary's Invitational.
Wildcats Bounce Back in Round Two of St. Mary's Invitational
The Arizona men's golf team jumped seven spots to fifth place at Poppy Hills Golf Course.
Donohue Leads Cats in Day One of Saint Mary's Invitational
Sophomore Max Donohue is tied for 19th after day one of the Saint Mary's Invitational.
Wildcats on the Road for the St. Mary's Invitational
Arizona sends six to Pebble Beach to compete with 14 of the nation's best.


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Page 1
Effects of topiramate and other anti-glutamatergic drugs on the
acute intoxicating actions of ethanol in mice: modulation by
genetic strain and stress
Yi-Chyan Chen1 and Andrew Holmes2,*
1 Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center,
Taipei, Taiwan
2 Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National
Institute on Alcoholism and Alcohol Abuse, NIH, Rockville, MD, USA
Compounds with anti-glutamatergic properties currently in clinical use for various indications
(e.g., Alzheimer's disease, epilepsy, psychosis, mood disorders) have potential utility as novel
treatments for alcoholism. Enhanced sensitivity to certain acute intoxicating effects (ataxia,
sedative) of alcohol may be one mechanism by which anti-glutamatergic drugs modulate alcohol
use. We examined the effects of six compounds (memantine, dextromethorphan, haloperidol,
lamotrigine, oxcarbazepine, topiramate) on sensitivity to acute intoxicating effects of ethanol
(ataxia, hypothermia, sedation/hypnosis) in C57BL/6J mice. Analysis of topiramate was extended
to determine the influence of genetic background (via comparison of the 129S1, BALB/cJ,
C57BL/6J, DBA/2J inbred strains) and prior stress history (via chronic exposure of C57BL/6J to
swim stress) on topiramate's effects on ethanol-induced sedation/hypnosis. Results showed that
one N-methyl-D-aspartate receptor (NMDAR) antagonist, memantine, but not another,
dextromethorphan, potentiated the ataxic but not hypothermic or sedative/hypnotic effects of
ethanol. Haloperidol increased ethanol-induced ataxia and sedation/hypnosis to a similar extent as
the prototypical NMDAR antagonist MK-801. Of the anticonvulsants tested, lamotrigine
accentuated ethanol-induced sedation/hypnosis, while oxcarbazepine was without effect.
Topiramate was without effect per se under baseline conditions in C57BL/6J, but had a synergistic
effect with MK-801 on ethanol-induced sedation/hypnosis. Comparing inbred strains, topiramate
was found to significantly potentiated ethanol's sedative/hypnotic effects in BALB/cJ, but not
129S1, C57BL/6J or DBA/2J strains. Topiramate also increased ethanol-induced sedation/
hypnosis in C57BL/6J after exposure to chronic stress exposure. Current data demonstrate that,
with the exception of MK-801 and haloperidol, the compounds tested had either no significant or
assay-selective effects on sensitivity to acute ethanol under baseline conditions in C57BL/6J.
However, significant effects of topiramate were revealed as a function of co-treatment with a
NMDAR blocker, genetic background or prior stress history. These findings raise the possibility
that topiramate and possibly other anti-glutamatergic drugs could promote the acute intoxicating
effects of ethanol in specific subpopulations defined by genetics or life history.
*Corresponding author: Andrew Holmes, PhD Section on Behavioral Science and Genetics Laboratory for Integrative Neuroscience
National Institute on Alcohol Abuse and Alcoholism 5625 Fishers Lane Room 2N09 Rockville, MD, USA 20852−9411 Email:
firstname.lastname@example.com Telephone: 301−402−3519 Fax: 301−480−1952.
Disclosure/Conflicts of interest The authors declare no conflicts of interest.
NIH Public Access
Author Manuscript
Neuropsychopharmacology. Author manuscript; available in PMC 2009 November 1.
Published in final edited form as:
Neuropsychopharmacology. 2009 May ; 34(6): 1454–1466. doi:10.1038/npp.2008.182.
NIH-PA Author Manuscript
NIH-PA Author Manuscript
NIH-PA Author Manuscript
Page 2
alcohol; glutamate; NMDA; AMPA; alcoholism; treatment
There is growing evidence that the glutamate system plays a major role in the neural and
behavioral actions of alcohol and the processes driving the development of alcoholism
(Heilig and Egli, 2006; Spanagel and Kiefer, 2008). In vitro, ethanol (EtOH) acts an
allosteric inhibitor of N-methyl-D-aspartate receptors (NMDAR) at behavioral intoxicating
doses, likely via direct receptor occupancy and actions on gating, as well as receptor
phosphorylation (Lovinger et al., 1989; Woodward, 2000). EtOH also inhibits the function
of L-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid ionotropic glutamate
receptors (AMPAR) in vitro, perhaps by facilitating receptor desensitization (Costa et al.,
2000; Fischer et al., 2003; Frye and Fincher, 2000; Lovinger et al., 1989; Moykkynen et al.,
2003). Furthermore, chronic exposure to EtOH produces an upregulation of NMDAR
protein levels, synaptic NMDAR clustering and NMDAR-mediated synaptic currents
(Carpenter-Hyland et al., 2004; Crabbe et al., 1991; Kumari and Ticku, 2000; Liu and
Weiss, 2002; Roberto et al., 2006; Smothers et al., 1997). These adaptive changes are
thought to contribute to the behavioral tolerance, acute withdrawal and increased alcohol
consumption that occurs with repeated EtOH exposure (Mulholland and Chandler, 2007).
Pharmacological or genetic blockade of glutamate receptors alters the behavioral effects of
EtOH. For example, NMDAR antagonists mimic the subjective feelings of intoxication in
humans and substitute for the discriminative stimulus effects of EtOH in mice (for
comprehensive review, see Gass and Olive, 2008). NMDAR inactivation reduces EtOH self-
administration and reward-related responses to EtOH and also attenuates withdrawal from
chronic EtOH exposure (Gass and Olive, 2008). On the other hand, when given in
combination with EtOH, NMDAR antagonists exacerbate the acute behavioral effects of
EtOH (Gass and Olive, 2008). Pharmacological blockade of AMPAR also reduces EtOH
consumption in alcohol-deprived mice, possibly via the GluR3 subunit, (Sanchis-Segura et
al., 2006), while gene deletion of the GluR1 subunit does not alter most acute responses to
EtOH (Cowen et al., 2003; Palachick et al., 2008). Finally, metabotropic glutamate receptor
(mGluR)-acting drugs such as MPEP (mGluR5 antagonist) and LY379268 (mGluR2/3
agonist) reduce EtOH self-administration in various assays (e.g., Backstrom et al., 2004;
Cowen et al., 2005; Hodge et al., 2006; Zhao et al., 2006).
Against the background of preclinical data, there is growing interest in the potential efficacy
of various clinically available drugs with 'anti-glutamatergic' properties for the treatment of
alcoholism (Krupitsky et al., 2007b). For example, the Alzheimer's disease medication
memantine has anti-alcohol craving effects in recovering alcoholics (e.g., Krupitsky et al.,
2007a; Krupitsky et al., 2007b); although a recent large double-blind study found no effect
in actively drinking alcoholics (Evans et al., 2007). Like memantine, the antitussive
dextromethorphan has NMDAR antagonist activity and appears to mimic the subjective
intoxicating effects of alcohol (Soyka et al., 2000). Although primarily known as an
antipsychotic and dopamine D2 receptor blocker, haloperidol also has NMDAR antagonist
effects and efficacy as a treatment for certain populations of alcoholics (e.g., Coyle, 2006;
Lynch and Gallagher, 1996). Lamotrigine, oxcarbazepine and topiramate represent a class of
anticonvulsant compounds with glutamate release inhibiting properties that shows
encouraging evidence as novel mediations for alcoholism. Lamotrigine attenuates
withdrawal (Krupitsky et al., 2007b) and reduces craving in alcoholics comorbid for
schizophrenia or bipolar disorder (Kalyoncu et al., 2005; Rubio et al., 2006). Although the
Chen and Holmes
Page 2
Neuropsychopharmacology. Author manuscript; available in PMC 2009 November 1.
NIH-PA Author Manuscript
NIH-PA Author Manuscript
NIH-PA Author Manuscript
Page 3
efficacy of oxcarbazepine in alcoholism has not yet been well established (Croissant et al.,
2006; Koethe et al., 2007; Schik et al., 2005), there is now good evidence that topiramate
reduces craving, withdrawal and drinking in recovering alcoholics (Johnson et al., 2004;
Johnson et al., 2003; Johnson et al., 2007; Komanduri, 2003; Krupitsky et al., 2007b; Rubio
et al., 2004; Rustembegovic et al., 2002).
Current models propose that alcohol abuse and alcoholism results from multiple risk factors,
including a drive to alleviate the negative reinforcing effects of alcohol withdrawal (Koob,
2003) and a progressive impairment of executive control over alcohol seeking (Everitt and
Robbins, 2005). Predisposition towards alcoholism is also associated with decreased
sensitivity/increased acute tolerance to certain intoxicating (e.g., ataxic) effects of EtOH
(Newlin and Thomson, 1990; Schuckit, 1994). However, although the aforementioned
preclinical literature supports a major interaction between experimental glutamate-acting
compounds and EtOH, it is currently unclear whether clinically tolerated 'anti-
glutamatergic' drugs also modulate (i.e., promote) the acute intoxicating effects of EtOH; an
effect that could contribute to their therapeutic profile. Thus, the aim of the present study
was to assess six clinically available compounds that have some degree of anti-
glutamatergic activity (memantine, dextromethorphan, haloperidol, lamotrigine
oxcarbazepine, topiramate) for effects on the acute intoxicating effects of EtOH in mice. To
provide a positive control, and to test for potential interactions (e.g., additive effects) with a
NMDAR antagonist that robustly potentiates the ataxic and sedative/hypnotic effects of
EtOH in mice (e.g., Palachick et al., 2008), each of the compounds was administered
alongside, or in combination with MK-801. In addition, because, of these compounds,
clinical and pre-clinical studies of topiramate have been the most extensive, we also tested
whether topiramate's effects on EtOH-induced sedation/hypnosis varied as a function of two
major influences on risk and treatment for alcoholism: genetic background and stress history
(Goldman et al., 2005; Grant et al., 2008; Koob, 2003).
Material and methods
Unless stated otherwise, subjects were male C57BL/6J mice obtained from The Jackson
Laboratory (Bar Harbor, ME). This strain was chosen as a reference strain given its common
use in models of alcoholism (Crabbe et al., 2006; Lopez and Becker, 2005) and because we
have recently characterized the effects of glutamate receptor manipulations on EtOH
behaviors in this strain (Boyce-Rustay and Holmes, 2005; Boyce-Rustay and Holmes, 2006;
Palachick et al., 2008). For the strain comparison experiment, subjects were 129S1/SvImJ
(hereafter abbreviated 129S1), BALB/cJ, C57BL/6J, and DBA/2J obtained from The
Jackson Laboratory. These strains were chosen based on their frequent use in behavioral
neuroscience, including studies of EtOH-related behaviors (e.g., Crabbe et al., 2006;
Millstein et al., 2006), as genetic backgrounds for mutants and inclusion as 'group A'
priority strains in the Mouse Phenome Project, an international effort to provide the
biomedical research community with phenotypic data on the most commonly used mouse
strains (www.jax.org/phenome). Mice were housed 2/cage in a temperature and humidity
controlled vivarium under a 12 h light/dark cycle (lights on 0600 h) with ad libitum access
to food and water. All experimental procedures were approved by the National Institute on
Alcohol Abuse and Alcoholism Animal Care and Use Committee and strictly followed the
NIH guidelines 'Using Animals in Intramural Research.'
General procedures
Sensitivity to EtOH's acute intoxicating effects was assessed using a battery of 3 behavioral
assays: EtOH-induced ataxia, hypothermia and sedation/hypnosis. Mice were tested on each
Chen and Holmes
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Neuropsychopharmacology. Author manuscript; available in PMC 2009 November 1.
NIH-PA Author Manuscript
NIH-PA Author Manuscript
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Page 4
assay with the assay involving the lowest dose (i.e., ataxia) first, followed by hypothermia
and sedation/hypnosis, with an interval of at least 1 week between tests. This regimen is not
expected to produce long-term tolerance to EtOH's effects (Crabbe, 2007). To our
knowledge, there is also no evidence that infrequent treatment with any of the 'anti-
glutamatergic' compounds tested here would produce tolerance or sensitization.
Nonetheless, to minimize this possibility and avoid a potential bias introduced by treating
the same group of mice with the same treatment, mice were randomly reassigned to drug
treatment groups between each of the 3 assays. For each assay, the effects of the 6 'anti-
glutamatergic' drugs were tested in 7−10 C57BL/6J mice per drug treatment (i.e., in each of
6 different treatment conditions, see below). Strain differences in responses to topiramate
were tested in 6−10 mice per strain, per drug treatment. Stress effects on responses to
topiramate were tested in 8 mice per stress condition, per drug treatment.
Rotarod training and EtOH-induced ataxia
EtOH-induced ataxia was assessed using the accelerating rotarod as previously described
(Hefner and Holmes, 2007; Rustay et al., 2003). The apparatus was a Med Associates
rotarod typically used for testing rats (model ENV-577). The 7-cm-diameter dowel was
covered with 320 grit sandpaper to provide a uniform surface that prevented mice gripping
the rubberized dowel. Mice were placed onto the rotarod dowel which was then accelerated
at a constant rate of 8 rpm/min up to 40 rpm. The latency to fall to the floor 10.5 cm below
was automatically recorded by photocell beams, with a maximum cutoff latency of 5 min.
Mice first received 10 consecutive training trials separated by a 30-sec inter-trial interval.
Change in latency to fall was measured by repeated measures analysis of variance. Results
showed that there was a significant increase in latency to fall across rotarod training trials in
the experiments assessing the effects of memantine (F9,423=25.15, p<.01, Supplemental
Fig. 1A), dextromethorphan (F9,423=18.75, p<.01, Supplemental Fig. 1B), haloperidol
(F9,459=28.94, p<.01, Supplemental Fig. 1C), lamotrigine (F9,513=31.92, p<.01,
Supplemental Fig. 1D), oxcarbazepine (F9,423=13.10, p<.01, Supplemental Fig. 1E), and
topiramate (F9,423=31.87, p<.01, Supplemental Fig. 1F).
Twenty-four hr after training, there was a baseline acclimation trial followed by 2 more
baseline trials (average=pre-drug performance). Mice were then injected intraperitoneally
(i.p.) with the 'anti-glutamatergic' drug followed, 30 min later, by either saline vehicle or
0.2 mg/kg MK-801 ((+)-5-methyl-10,11-dihydro-SH-dibenzo[a,d]cyclohepten-5,10-imine
maleate) (dissolved in a 0.9% saline vehicle). Thirty min later, mice were injected with 1.75
g/kg EtOH (for schematic of treatment procedure, see Supplemental Fig. 2). For this (and
the 2 assays below) EtOH (200 proof) was prepared in 0.9% saline to produce 20% v/v
solutions and injected i.p. with the dose determined by manipulating the volume of injection.
Thirty min after EtOH challenge, there was 1 acclimation trial followed by 2 test trials
(average=post-drug performance). The dependent measure was the difference in pre- versus
post-drug performance (=delta latency). Note, we have previously shown that 0.2 mg/kg
MK-801 per se does not produce significant rotarod ataxia in C57BL/6J mice (Palachick et
al., 2008).
EtOH-induced hypothermia
EtOH-induced hypothermia was tested as previously described (Hefner and Holmes, 2007).
Basal core body temperature was first measured by inserting a Thermalert TH-5
thermometer (Physitemp, Clifton, NJ, USA) 2 cm into the rectum until a stable reading was
obtained. Mice were then injected with the 'anti-glutamatergic' drug followed, 30 min later,
by saline vehicle or 0.2 mg MK-801. Thirty min later, mice were injected with 3.0 g/kg
EtOH (for schematic of treatment procedure, see Supplemental Fig. 2). Temperature was
measured prior to each drug treatment and 30, 60, 90, and 120 min later to provide an
Chen and Holmes
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Neuropsychopharmacology. Author manuscript; available in PMC 2009 November 1.
NIH-PA Author Manuscript
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Page 5
average post-EtOH measure. The difference between pre-EtOH (i.e., post-'anti-
glutamatergic drug'/post-MK-801) and post-EtOH temperature was taken as the dependent
measure (=delta temperature). Ambient room temperature was 23°C. Note, we have
previously reported that 0.2 mg/kg MK-801 per se does not produce hypothermia in C57BL/
6J mice (Palachick et al., 2008).
EtOH-induced sedation/hypnosis
EtOH-induced sedation/hypnosis was assessed as previously described (Daws et al., 2006).
Mice were then injected with the 'anti-glutamatergic' drug followed, 30 min later, by saline
vehicle or 0.2 mg/kg MK-801. Thirty min later, mice were injected with 3.0 g/kg EtOH (for
schematic of treatment procedure, see Supplemental Fig. 2) and immediately placed into the
supine position in a 'V'-shaped chamber. Sleep time was measured as the time from
injection to recovery of the righting reflex (turning onto all 4 paws twice in 30 sec after
initial self-righting), with a maximum latency of 180 min before the experiment was
terminated. To measure blood EtOH concentrations (BECs) at recovery, mice were
sacrificed via cervical dislocation and rapid decapitation and trunk blood was taken for
analysis using the Analox AM1 Alcohol Analyzer (Analox Instruments USA Inc,
Lunenburg, MA). Note, we have previously reported that 0.2 mg/kg MK-801 per se does not
produce sedation/hypnosis in C57BL/6J mice (Palachick et al., 2008).
Effects of memantine, dextromethorphan, haloperidol
The effects of pre-treatment with memantine (1-amino-3,5-dimethyl-adamantane),
dextromethorphan ((+)-3-methoxy-17-methyl-(9α,13α,14α)-morphinan) and haloperidol (4-
[4-(4-chlorophenyl)-4-hydroxy-1-piperidyl]-1-(4-fluorophenyl)-butan-1-one) were tested as
described above. Memantine (7.5 and 15 mg/kg), dextramethorphan (30 and 60 mg/kg) and
haloperidol (0.15 and 0.30 mg/kg) were dissolved in a 0.9% saline vehicle, which also
served as the 0 mg/kg dose and injected i.p. in a volume of 10 mL/kg body weight. Doses
were chosen on the basis of prior behavioral studies in rats and mice: memantine (Holter et
al., 1996; Piasecki et al., 1998), dextramethorphan (Erden et al., 1999), haloperidol
(Karlsson et al., 2008; Wiedholz et al., 2008), as well as pilot work showing that when
injected alone (i.e., without EtOH) these doses did not produce significant rotarod ataxia or
sedation/hypnosis (effects on core body temperature are described in the Results below). All
3 drugs were obtained from Sigma (St. Louis, MO).
Effects of lamotrigine, oxcarbazepine, topiramate
The effects of pre-treatment with lamotrigine (6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-
diamine), oxcarbazepine (10,11-Dihydro-10-oxo-5 H -dibenz(b,f)azepine-5-carboxamide)
and topiramate (2,3:4,5-bis-O-(1 methylethylidene)-[beta]-D-fructopyranose sulfamate)
were tested as described above. Lamotrigine (15 and 30 mg/kg) was dissolved in 30%
DMSO, which served as the 0 mg/kg dose for this drug. Topiramate (25 and 50 mg/kg) was
dissolved in 0.9% physiological saline, which also served as the 0 mg/kg dose. Both drugs
were injected i.p. in a volume of 10 mL/kg body weight. Oxcarbazepine (25 and 50 mg/kg)
was dissolved in 60% DMSO, which served as the 0 mg/kg dose, and injected i.p. at a
(lower) volume of 5 mL/kg body weight. Doses were chosen on the basis of prior behavioral
studies in rats and mice: lamotrigine (Brody et al., 2003; Vengeliene et al., 2007),
oxcarbazepine (Beijamini et al., 1998), topiramate (Gabriel and Cunningham, 2005;
Hargreaves and McGregor, 2007; Knapp et al., 2007a; Nguyen et al., 2007) and pilot work
showing that when injected alone (i.e., without EtOH) these doses did not produce
significant rotarod ataxia or sedation/hypnosis (effects on core body temperature are
described in the Results below). All 3 drugs were obtained from Sigma (St. Louis, MO).
Chen and Holmes
Page 5
Neuropsychopharmacology. Author manuscript; available in PMC 2009 November 1.
NIH-PA Author Manuscript
NIH-PA Author Manuscript
NIH-PA Author Manuscript


text:
Pamela Parker | July 5, 2006 | Comments
A couple of financings making news today may have some impact on the interactive marketing space
A couple of financings making news today may have some impact on the interactive marketing space.
Pro Rank Tracker is a cutting-edge ranking tracking tool for keeping you up-to-date with all the latest changes in the rankings of your websites and videos.
Pamela Parker is a former managing editor of ClickZ News, Features, and Experts. She's been covering interactive advertising and marketing since the boom days of 1999, chronicling the dot-com crash and the subsequent rise of the medium. Before working at ClickZ, Parker was associate editor at @NY, a pioneering Web site and e-mail newsletter covering New York new media start-ups. Parker received a master's degree in journalism, with a concentration in new media, from Columbia University's Graduate School of Journalism.
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text:
Rotom at any time, and we don't know how much of it we'll see in the future. None of Oak's Pokémon has appeared more than once.
Rotom at any time, and we don't know how much of it we'll see in the future. None of Oak's Pokémon has appeared more than once.
Rotom with a pokemon so clearly someone is reappearing.
No episode with a important character appearing or a capture is a filler, simple as that.
Dragonite, and neither Pidgey nor its evolutions would be effective against Rotom. Charmeleon would be nice, but a reference to Movie 4 seems unlikely.
War Room Awards '14: Best New Player, Most Sportsmanlike Conduct, Most Friendly User.
War Room Awards '15: Most Sportsmanlike Conduct.
19 games played. Host of ARC-V Mafia and Random Messages Mafia.
About to co-host Video Games mafia with AussieEevee. You can sign up here if interested.
Well, I don't think a capture episode can be considered as a filler, regardless who's catching it.
Profesor Oak doesn't need another pokemon. He has to take care of Ash's hoarding problem.
I hear them coming for me, because the top is lonely
You could be king, but watch the queen conquer
You aren't suggesting an evolution or a new forme are you? I guess it could be and we could get it in the next CororCoro, or the one after and then it could be in this episode, but I assume it would've at least hinted to that in the title or a summary of the episode. Unless it's advertising for an upcoming Rotom giveaway.
I just hope that it won't be similar to that other Rotom episode.
focusing on Rotom and all of its forms, just like the episode scan showcases. (To be fair, they have done other promotions of Pokemon that didn't line up with anime episodes, but this one seems close enough together to draw that conclusion.)
Heh, I actually posted earlier in the thread thinking it might be a new form
I don't think we'd see a new form/evolution in this episode per se, but it seems to be going somewhere that it's implied that Oak wants to study them, in that there may be a reason later for this?
I hear them coming for me, because the top is lonely
You could be king, but watch the queen conquer
Or it could just be an episode to show off Professor Oak and Rotom, whether it be for another promotional purpose like a future giveaway or because they want to have another Rotom episode.
I can't wait to see Iris and Cilan interacting with Professor Oak in person and maybe Ash could tell Iris and Cilan more about his older Pokemon and previous journeys, unless that will happen when Ash goes back to Kanto.


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CyberPatriot Students Gain The Fanatical Edge
In an unassuming and antiquated shopping mall, in an older area of the greater San Antonio area in Windcrest, it is hard to consider that the skills of tomorrow are growing and strengthening. Rackspace, a global leader in hosting technologies and co-founder of OpenStack, has been redesigning the corporate headquarters of the future out of the shell of an abandoned consumer marketplace from yesteryear. As Rackspace planted its roots firmly in San Antonio soil, the company continually looked for ways to enmesh itself, and the Rackers who power its Fanatical Support approach, through community interactions and outreach. Enter a day and age where Rackspace is on the mouths of every San Antonio student who had the opportunity to experience one of the events that the company puts together.
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text: Twilight 11/11/09 Test Your Twilight Knowledge For a Chance to Win a Sexy DvF Bag! Read More TwilightAsideDVF Twilight 10 New Book Series That Recapture That Twilight Magic 9 Twilight Fan Fictions Better Than Fifty Shades of Grey Kristen Stewart Tells You How the Twilight Contest Will Work 13 Successful First Novels by Female Writers POPSUGAR, the #1 independent media and technology company for women. Where more than 75 million women go for original, inspirational content that feeds their passions and interests. Be in the Know With OurCelebrity and Entertainment Newsletter Personalize Young Hollywood Movies TV A-Listers Sign up with facebook or By signing up, I agree to the Terms and to receive emails from POPSUGAR.


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You won't be able to dismiss this by usual means (escape or click button), but you can close it programatically based on user choices or actions.
"Invitations came 1 week early which was great and the quality was what I expected. Invitations looked exactly how they do on the website including color, font, etc. Great product!"
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Market Segmentation
How to do it, how to profit from it
- Malcolm McDonald, Until recently, Professor of Marketing and Deputy Director of Cranfield School of Management and formerly Marketing Director of Canada Dry, UK
- Ian Dunbar, Has worked with numerous companies around the world in segmentation workshops and research projects. He has held senior marketing positions in companies from both the service and manufacturing sectors and obtained his MBA from Cranfield University School of Management in the UK
* McDonald and Dunbar are the leading author team in this area* Segmentation and marketing mapping are core areas of the marketing syllabus, and there is much that is new as a result of the new segmentation possibilities from e-marketing and e-business* The book has a textbook feel, which highlights the diagrams and market maps (key elements of the book)This is a key book, in a vital area. The Butterworth-Heinemann edition of what was previously published by MacMillian, is a thoroughly revised and updated version.View full description
Undergraduate and postgraduate marketing students, and marketing professionals.
Book information
- Published: September 2004
- Imprint: BUTTERWORTH HEINEMANN


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Rieker Roger 12 Boot (Men's)
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The Rieker Roger 12 Boot is an instant winter favorite for men. Classic styling with rich leather and wool gives the Roger its characteristic look. Since it's lined in new wool, this shoe is very warm and very soft. A rubber sole provides plenty of traction, making this boot as practical as it is stylish. Whether you choose to dress it up or wear it casually, the Roger will never miss the mark.
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updated 10/06/2009 AT 10:00 AM ET
•originally published 10/07/2009 AT 9:15 AM ET
When life hands you divorce … turn it into a hit song?
That seems to be Usher's strategy with his still untitled new album. He's taking an equally adversarial tone in his lilting first single, "Papers," in which the R&B star sings that he's ready to move on.
The tune, which premiered online Monday, references pivotal moments in Usher's personal life, including his decision to fire his mother as his manager. "I gave my heart and turned my back against the world 'cuz you were my girl," he sings, continuing, "I done damn near lost my mama/I done been through so much drama/I done turned into the man I never thought I'd be/I'm ready to sign them papers."


text:
Albergo Cavour
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TripAdvisor Reviews Albergo Cavour Palermo
Travel Blogs from Palermo
... black fat guy). On the first night a woman from New Zealand came to stay, Demelza. The street along the vucciria suddenly filled with people at about 23:00, chairs and tables come out and music starts blaring, so we went to check out the action and join in! We went for an asperitivo (cocktails and unlimited food) and a beer and watched the party start. It didn't end until about 5 in the morning, even then children still run the streets playing, ...
Excursion to Cefalu
... at 1 pm.
A quick walk brought us to the church and its adjacent monastery where we could do the entire tour before closure. d
The other attraction of Cefalu is the Temple of Diana at the top of the hill in the middle of the city.
It is an archeological site where there are remnants of old civilization and most importantly you climb almost 200 metres and get a spectacular view over the city from the height. It was well worth the climb.
Meanwhile ...
Wednesday, July 22, 2015
Cui va 'n Palermu e 'un vidi Murriali, si nni parti sceccu e torna armali.
English translation: Whoever goes to Palermo and doesn't see Monreale, goes there a jackass and returns a fool.
today was Palermo ...
From the bike to the car
... is an indication to take a bus to the rental car center. After waiting for about 15 minutes the rental bus arrives and brings us to a shed about 500 meters from the terminal. Wait for another hour to get your turn, after all the document signing, the next step is to go to the parking lot to meet his colleague. Over there, the papers are not correct, so wait for another 30 minutes to get the papers corrected, and while I wrote that this was a duplicate of ...
Falcone and Borsellino memorial day
... seeing all the students involved in the event at the theatre, and in the rally, although I am aware that some of them participated only to have a good excuse to skip school. It was also good to confront with some of the Addiopizzo members about their memories of the killings of Falcone and Borsellino, and on how they feel that Palermo has changed since then. We concluded the day how only a truly Italian can do: by sitting at a bar and chatting in front of a delicious ice cream!
Other places to stay in Palermo
San Paolo Palace Hotel Centro CongressiGuadagna, Palermo | 4 star hotelfrom $79
NH PalermoTribunali, Palermo | 4 star hotelfrom $110
- Jolly Hotel
- Good Location
- A really nice reasonable standard Hotel
Grand Hotel et Des PalmesPoliteama, Palermo | 4 star hotelfrom $110
Excelsior Hilton PalermoPoliteama, Palermo | 4 star hotelfrom $90
- A grand hotel
- Disappointing location in city
- Hated it -- avoid the third floor
Grande Albergo SoleSeralcadio, Palermo | 4 star hotelfrom $73
Ibis Styles PalermoPoliteama, Palermo | 4 star hotelfrom $88
Albergo MediterraneoCastellammare, Palermo | 3 star hotelfrom $58
Grand Hotel Villa IgieaPoliteama, Palermo | 5 star hotelfrom $237
- Fond memories of the Villa Igiea
- More beautiful than the photos on their website - Great service!!
- Villa Igiea: Elegant old hotel outside Palermo
Centrale Palace HotelCorso Vittorio Emanuele 327, Palermo | 4 star hotelfrom $123
- Excellent and spectacular!
- Scary area of town
- Depressing Hotel
Idea Hotel PalermoTerza Circoscrizioni, Palermo | 4 star hotelfrom $81
Mercure Palermo CentroCastellammare, Palermo | 4 star hotelfrom $75
- A haven from the noise!
- Diverse
- Remarkable value
Politeama Palace HotelPoliteama, Palermo | 4 star hotelfrom $82
Astoria Palace HotelPoliteama, Palermo | 4 star hotelfrom $68
Casena dei ColliResuttana - San Lorenzo, Palermo | 3 star hotelfrom $77
Mondello Palace HotelPartanna, Palermo | 3 star hotelfrom $162
Casa MarconiQuarta Circoscrizioni, Palermo | 1 star hotelfrom $55
Addaura Hotel Residence CongressiPartanna, Palermo | 3 star hotelfrom $77
Hotel GaribaldiPoliteama, Palermo | 4 star hotelfrom $85
Athenaeum PalermoVia Giannettino, 4, Palermo | 3 star hotelfrom $75
Hotel Bel 3Quarta Circoscrizioni, Palermo | 3 star hotelfrom $72
Hotel Columbia PalermoSeralcadio, Palermo | 2 star hotelfrom $64
Hotel Europa PalermoPoliteama, Palermo | 3 star hotelfrom $58
Splendid Hotel La TorreKirkdale, Palermo | 3 star hotelfrom $85
Hotel AlessandraTribunali, Palermo | 2 star hotelfrom $65
Hotel Gallery HousePoliteama, Palermo | 4 star hotelfrom $86
Amarcord HotelPoliteama, Palermo | 4 star hotelfrom $85