text:
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Flexibility in energy metabolism supports hypoxia
tolerance in Drosophila flight muscle: metabolomic
and computational systems analysis
Jacob D Feala1, Laurence Coquin2, Andrew D McCulloch1and Giovanni Paternostro1,2,*
1Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA and2The Burnham Institute for Medical Research, La Jolla, CA, USA
* Corresponding author. Degenerative Disease Research, The Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Tel.: þ1 858 713 6294; Fax: þ1 858 713 6281; E-mail: email@example.com
Received 16.1.07; accepted 11.2.07
The fruitfly Drosophila melanogaster offers promise as a genetically tractable model for studying
adaptation to hypoxia at the cellular level, but the metabolic basis for extreme hypoxia tolerance in
flies is not well known. Using1H NMR spectroscopy, metabolomic profiles were collected under
hypoxia. Accumulation of lactate, alanine, and acetate suggested that these are the major end
products of anaerobic metabolism in the fly. A constraint-based model of ATP-producing pathways
was built using the annotated genome, existing models, and the literature. Multiple redundant
pathways for producing acetate and alanine were added and simulations were run in order to find a
single optimal strategy for producing each end product. System-wide adaptation to hypoxia was
then investigated in silico using the refined model. Simulations supported the hypothesis that the
ability to flexibly convert pyruvate to these three by-products might convey hypoxia tolerance by
improving the ATP/Hþratio and efficiency of glucose utilization.
Molecular Systems Biology 17 April 2007; doi:10.1038/msb4100139
Subject Categories: metabolic and regulatory networks; cellular metabolism
Keywords: constraint-based model; Drosophila melanogaster; hypoxia; metabolomics
Understanding cellular adaptation to hypoxia is central to the
design of treatments for injury caused by ischemia–reperfu-
sion, stroke, and myocardial infarction. Cell damage during
acute hypoxia is thought to be caused by imbalances such as
decreased pH, altered calcium homeostasis, increased intra-
cellular osmotic pressure, and mitochondrial damage, result-
ing directly and indirectly from decreased ATP (Hochachka
and Somero, 2002; Corbucci et al, 2005). Humans have
complex physiological systems for regulating oxygen home-
ostasis that involve multiple spatial scales and cell types and
have been delicately tuned during evolution. However, at the
cellular level, hypoxia resistance mechanisms most likely
evolved very early and appear to be highly conserved among
species (O'Farrell, 2001).
Lending support to this hypothesis, several genes have been
discovered in the fruitfly Drosophila melanogaster that are
similar in sequence and function to human genes for
regulation of metabolism, signaling, and transcription during
hypoxia (Piacentini and Karliner, 1999; Wingrove and
O'Farrell, 1999; Lavista-Llanos et al, 2002; Pan and Hardie,
2002).Although hypoxia defenses in flies and humans seem to
be quite similar at the level of individual genes, stark contrasts
exist at the phenotype level. Drosophila have a remarkable
tolerance to hypoxia that is the subject of an increasing
amount of investigation (O'Farrell, 2001; Haddad, 2006). In
contrast to humans, who can only survive a few minutes
without oxygen, flies can fully recover from up to 4h in
generation of ATP are likely to be part of the reason for the
disparity in hypoxia tolerance between humans and flies;
however, Drosophila anaerobic metabolism is not well known.
Aerobic energy metabolism in insect flight muscle is similar
to that of humans in most respects; however, there are some
major differences that distinguish the species, such as the use
of proline as an energy source, heavy reliance on the a-
glycerol-3-phosphate shuttle, and the use of arginine as an
alternative to creatine for ATP buffering (Gilmour, 1961).
Anaerobic energy pathways in Drosophila are likely to deviate
from those of humans as well. In human muscle, glycolysis is
product of anaerobic metabolism (Nelson, 2000; Wadley et al,
2006). Many terrestrial insects yield lactate and alanine as
anaerobic end products, but other species have been known to
produce a wide array of other products during hypoxia,
pyruvic acid, and fatty acids (Hoback and Stanley, 2001). The
specific end products for Drosophila are not known; however,
the wide diversity of insect biochemistry suggests that exotic
& 2007 EMBO and Nature Publishing Group Molecular Systems Biology 2007 1
Molecular Systems Biology 3; Article number 99; doi:10.1038/msb4100139
Citation: Molecular Systems Biology 3:99
& 2007 EMBO and Nature Publishing Group All rights reserved 1744-4292/07
Page 2
pathways for anaerobic energy production may also exist in
flies (Gilmour, 1961; Hoback and Stanley, 2001).
Regardless of the pathways used, anaerobic metabolism
must be regulated over the long term to balance pH, ATP
production, redox potential (most importantly, NADH/
NADþ), and coupling metabolites. Although strategies for
maintaining these balances are known for many organisms
(Hochachka, 1980), quantitative systems models can increase
mechanistic understanding. A major advantage of a mathe-
matical model is that conservation of mass is enforced;
therefore, all elements and charges are balanced within the
system, including electron transport, cofactor concentration,
and protons (pH). The constraint-based method uncovers the
space of all possible steady-state solutions under a set of
physiochemical limitations imposed on the system (Palsson,
2004). These network models are useful both for performing
detailedin silicoexperimentsandfordiscoveringmoregeneral
systems-level properties (Almaas et al, 2004; Reed and
Palsson, 2004).
Focusing on Drosophila flight muscle, we used NMR
metabolomic analysis to discover end products of anaerobic
energy metabolism. We then added all pathways that might
produce these compounds, linked them to existing Drosophila
genes, and built them into a constraint-based model of fly
energy metabolism. Simulations were used to select specific
anaerobic pathways from a number of alternatives by
optimizing for ATP production. Metabolite fluxes measured
by NMR were integrated into the model and simulations were
conducted to investigate production of ATP, Hþ, and glucose
during hypoxia. Simulations were compared with those of
classical anaerobic energy pathways in mammals to generate
hypotheses for mechanisms of hypoxia tolerance in flies.
Results and discussion
Global metabolite profiles under hypoxia
Of the 21 compounds with at least one sample measurement
greater than 0.05mM, six were found to change significantly
according to one-way analysis of variance (ANOVA): acetate,
alanine, arginine, glucose, lactate, and threonine. All six
compounds had a statistically significant linearly increasing
trend. Three compounds (acetate, alanine, and lactate) had
high R2goodness-of-fit values and significant changes among
several time points. In the remaining three (arginine, glucose,
and threonine), only the 4-h hypoxia group was significantly
different from the rest. Figure 1 displays the statistically
significant subset.
One common behavior was that the concentration of a
metabolite remains stable for the first hour of hypoxia, but
shows a large increase at 4h. Glucose, threonine, and arginine
show a statistically significant difference from early time
points to the 4h concentration. As the survival rate for anoxic
flies at 251C is very high for the first few hours and then starts
that these metabolites are an early indication of the loss of
homeostasis, that is, the breakdown of the system under
stress. Mechanisms for protecting the cell and balancing
metabolic requirements may begin to lose effectiveness at
some threshold period of time. For example, a likely explana-
Metabolites affected by hypoxia
Concentration (mM)
Control (4h)
Hypoxia 10 min
Hypoxia 1h
Hypoxia 4h
* significant by one-way ANOVA, P<0.0023 (Bonferroni corrected)
† only 4-h time point significant byTukey multiple comparison test
Figure 1
in homeostasis.
Metabolites significantly altered during hypoxia, measured by1H NMR spectroscopy. Lactate, alanine, and acetate accumulate over the time course of the
Systems analysis of hypoxia tolerance in Drosophila
JD Feala et al
2 Molecular Systems Biology 2007
& 2007 EMBO and Nature Publishing Group
Page 3
tion for the time course of glucose is that this substrate is
replenished by a steady depletion of trehalose and glycogen
supplies during the manageable first hour of hypoxia. At 4h,
glucosesupplyundergoesalargeincrease,whichsuggests that
the system has experienced a drastic reduction in its ability to
utilize carbohydrate substrates.
Steady accumulation of lactate, alanine, and acetate is the
second phenomenon that can be seen in the NMR spectra. The
end products of anaerobic metabolism in Drosophila were not
previously known. However, the discovery of lactate and
alanine accumulation is consistent with the fact that these
compounds, which do not accumulate under normal condi-
tions, are known to be the by-products of anaerobic
metabolism in other terrestrial insects (Hoback and Stanley,
2001). During hypoxia, lactate fermentation regenerates
NADþfor glycolysis, with the trade-off of decreasing pH
(Nelson, 2000), and certain other organisms have alanine and
acetate fermentation pathways that perform a similar function
(Gade, 1984; Hochachka and Somero, 2002). Table I contains
calculated results of accumulation during the hypoxia experi-
Reconstruction and expansion of Drosophila
metabolic network
We built and validated a constraint-based model of known
ATP-producing pathwaysin Drosophila. Results from the NMR
the model, as well as incorporate quantitative flux data. These
results suggest that the major metabolites that accumulate
under hypoxic conditions are lactate, alanine, and acetate. We
expanded the scope of the model to include several alternative
pathways for generating alanine and acetate from pyruvate,
and then integrated NMR measurements by placing con-
straints on the steady-state flux out of the system.
In other organisms, alanine is produced during hypoxia by
transamination to pyruvate from another amino acid. In
mammals, this pathway involves the cycling of a-oxoglutarate
(also known as a-ketoglutarate) and glutamate (Nelson, 2000)
through enzymes that are also present in flies. We added two
transaminations to the model based on genetic evidence in the
KEGG pathway database (Ogata et al, 1999): alanine-a-
oxoglutarate transaminase (using glutamate as in mammals)
and alanine-glyoxylate transaminase (using glycine and
pyruvate as substrates).
Acetate production has been previously hypothesized as a
possible mechanism for dealing with mitochondrial acetyl-
CoA that cannot be catabolized further in the absence of
oxygen (Hochachka, 1980). The benefits of this pathway are
two-fold.Acetate is aweakeracid than lactate (pK is 4.8 versus
3.7); also hydrolysis of acetyl-CoA to acetate by acetate-CoA
ligase is ADP linked, offering the additional benefit of ATP
production. Genetic evidence in flies (from KEGG) also
suggests alternative pathways for acetate production from
pyruvate via acetyl-phosphate or acetaldehyde. These reac-
tions were added along with the acyl-carnitine shuttle for
transport of mitochondrial acetyl-CoA to the cytosol.
Hypoxia simulation
There are several benefits of using a quantitative model to test
and generate hypotheses about hypoxic energy metabolism.
First, although much is known about the individual pathways,
it becomes very hard to manually calculate and predict
behavior when pathways are combined into an integrated
network. With a few reasonable assumptions, steady state in
this study for example, some of the vast knowledge contained
in the literature and public databases can be compiled into a
comprehensive, predictive model into which individual
experiments, such asour metabolomic data, can beintegrated.
In this mathematical model, the complicated problems of
balancing redox potential and accounting for proton produc-
tion are solved intrinsically during flux-balance analysis.
Every simulation of hypoxia produced a flux distribution
that utilized only one pathway each for production of alanine
and acetate, among multiple alternatives. Alanine formation
used the glutamate-dependent alanine transaminase, as
Drosophila lack the capability to further metabolize glyoxylate
producedbythealternativetransaminase reaction. Toproduce
acetate, the model utilized the acetyl-CoA synthetase reaction
in every simulation. Fluxes through these reactions were
constrained to a maximum determined by the NMR data, but
were not set explicitly; rather, the model utilized these
pathways to optimize ATP production under hypoxic condi-
tions (Figure 2).
Our model was used to simulate Drosophila ATP production
ranging from normoxia to anoxia, using two different systems:
the first allowing lactate, alanine, and acetate to accumulate
through known and hypothesized pathways, and the second
allowing only lactate to accumulate through the fermentation
pathway also used by mammals ('pseudo-mammalian' in
Figure 3). Figure 3 shows a clear advantage in converting
pyruvate to acetate and alanine during all low-oxygen
conditions. Figure 3A plots important fluxes under varying
oxygen levels. Figure 3B compares these fluxes when alanine
and acetate production are constrained to zero and the
constraint on lactate accumulation is removed. Using path-
ways that generate alanine and acetate decreases proton
production, increases ATP generation (Figure 3C), and
decreases glucose uptake under all hypoxic and anoxic
conditions simulated.
The ability to withstand hypoxia strongly depends on the
ability to control pH within the system, while maintaining ATP
production. The ATP/Hþratio is a simple indicator of the
likelihood of hypoxia tolerance of an organism (Hochachka
and Somero, 2002), as it directly quantifies the physiological
tradeoff between generating energy for the system and
maintaining pH levels required for homeostasis. Another
Table I Approximation of end-product accumulation from NMR data
Product Goodness-of-fit
Slope of trendline
Accumulation of substrate was calculated using 500ml sample volume and 20
flies per sample.
Systems analysis of hypoxia tolerance in Drosophila
JD Feala et al
& 2007 EMBO and Nature Publishing GroupMolecular Systems Biology 2007 3
Page 4
of quantifying the decreased efficiency of fuel utilization as
respiration, the most efficient pathway, is restricted. As all
simulations of restricted oxygen produce more ATP, use less
glucose, and accumulate fewer protons in the acetate- and
alanine-producing system, the model suggests that these
mechanisms contribute to hypoxia tolerance in flies.
Both NMR metabolomic profiling and quantitative systems
modeling suggest that having more possibilities for the
fermentation products of pyruvate may contribute to hypoxia
tolerance in fruitflies. Our approach can be used to generate
and test new hypothesesabout the metabolic basisfor hypoxia
tolerance. Further experiments using 13-carbon-labeled iso-
topomers can add sensitivity to NMR measurements and
Figure 2
lactate,alanine, andacetate (inred)during hypoxia. Ofthe two pathwaysfor creating alanine (purple box) andfouroptions for creating acetate (blue box) from pyruvate,
optimization of the model selected one optimal route for generating each end product (non-zero fluxes in color).
Pathways of ATP generation during hypoxia. The network includes glycolysis, TCA cycle, and oxidative phosphorylation, as well as reactions for generating
Systems analysis of hypoxia tolerance in Drosophila
JD Feala et al
4 Molecular Systems Biology 2007
& 2007 EMBO and Nature Publishing Group
Page 5
directly trace intrasystem fluxes (Sauer, 2006). In addition,
enzyme mutations can be simulated by adding flux con-
straints, and a system-wide perturbation analysis can be
Drosophila gene deletion library (Spradling et al, 1999) by
applying further NMR, phenotypic, and biochemical experi-
ments on mutants suggested by the model.
Materials and methods
Fly preparation
Oregon-R wild-type flies were reared in constant darkness at 251C.
When they were 3–5 days old, they were brought into light
approximately 4h before the experiment.
Hypoxia experiments
The hypoxia experiments included five samples for each of the five
conditions: control, 10min hypoxia, 1h hypoxia, 4h hypoxia, and 4h
control. As the vials used for experiment did not contain food, the 4-h
controlwas included to offset the effects of starvation and dehydration
over the same time period. Holes were drilled in the screw caps of
Sarstedt 15-ml vials and rubber tubing was inserted into each cap and
sealed airtight with silicone adhesive. At the time of experiment, filter
paper was soaked in distilled water and placed in each vial to prevent
drying. Approximately 50 flies were transferred and the caps were
screwed loosely onto each vial to allow gas to flow out. A mixture of
nitrogen and 0.5% oxygen was then bubbled through distilled water
and passedthrough the tubinginto thevials.After 5min of application
order. Control flies were sealed in vials with wet filter paper, but
without the application of gas. Vials were lightly shaken to increase
spacing among immobile flies and stored on their side at 251C. At the
end of each time point, vials were snap frozen in liquid nitrogen and
frozen flies were transferred for storage at ?801C.
Females were separated from males on dry ice under a dissecting
microscope, then, using forceps and miniature spring scissors (Fine
Science Tools Inc., 15003-08), 20 thoraces were separated from the
head and abdomen and placed into Eppendorf vials in liquid nitrogen.
Thoraces were homogenized in an ice bath for 10min in 300ml of cold
1:1 acetonitrile:water buffer, homogenates were centrifuged in a cold
room (41C) for 10min at 13000r.p.m., and the supernatant was
ultracentrifugated for 30min at 8500r.p.m. using Nanosep centrifugal
devices (Pall Life Sciences, Ann Arbor, MI) with a 3kDa molecular
weight cutoff. To reduce the contamination of glycerol, a membrane
preservative, to below 80mM, all Nanosep devices were washed four
times (by 5min centrifugation at 13000r.p.m.) with 500ml deionized
water. Filtrate was lyophilized using a vacuum centrifuge for 2h at
451C. Dried samples were then dissolved in 500ml D2O buffered at pH
7.4 with monobasic/dibasic sodium phosphate. The NMR standard
TSP (3-trimethylsilyl-2H4-propionic acid) was added to the samples at
a ratio of 1:100 by volume, resulting in a concentration of 0.488mM.
Samples were stored at 41C until measured.
NMR spectroscopy and data analysis
Analyses of samples were carried out by1H NMR spectroscopy on a
Bruker Avance 500 operating at 500.13MHz1H resonance frequency.
The NMR probe used was the 5mm TXI1H/2H-13C/15N Z GRD. All
NMR spectra were recorded at 301C. Typically,1H were measured with
0 20406080 100
Flux (pmol/fly min)
Pseudo-mammalian (lactate only)
0 2040 6080 100
Flux (pmol/fly min)
Stable pH
0 20 40 6080100
Flux (pmol/fly min)
lactate only
Drosophila (lactate, alanine, acetate)
Reduced glucose
Oxygen uptake (% of max)
Oxygen uptake (% of max)
ac, ala, lac produced
Oxygen uptake (% of max)
ATP production
Figure 3
oxygen levels as pyruvate begins to be fermented to alanine, acetate, and
lactate. Glucose uptake is decreased during restricted oxygen. (B) When
pyruvate is only allowed to be converted to lactate (pseudo-mammalian), proton
production is much higher and glucose uptake remains constant during hypoxia,
whereas (C) ATP production remains the same or better. Abbreviations: ac:
acetate accumulation; ala: alanine accumulation; atp: ATP production; CO2: CO2
production; glc: glucose uptake; h: proton production and lac: lactate
Results of flux-balance analysis on the model of Drosophila ATP-
Systems analysis of hypoxia tolerance in Drosophila
JD Feala et al
& 2007 EMBO and Nature Publishing GroupMolecular Systems Biology 2007 5


text:
An Introduction to Organisational Behaviour for Managers and Engineers
A Group and Multicultural Approach
- Duncan Kitchin, Sheffield University Management School
This book aims to support courses that go towards meeting the ECUK requirements for management and business training, with coverage of team and group working, and further discussion of international cultural difference, which are major features of engineering degrees today. Chapters also cover key issues for maintaining a healthy working environment within an organisation, such as motivating employees, managing stress and dealing with organisational politics, as well as subjects to provide a greater understanding of company management including leadership and organizational structures.
An Introduction to Organisational Behaviour for Managers and Engineers provides not only a practical introduction to OB for management students, but also a text that is specifically aimed at the needs of engineers and students of engineering.
Introductory OB text for Engineers and Business students on management short courses and one semester modules.
Book information
- Published: March 2010
- Imprint: BUTTERWORTH HEINEMANN
Table of Contents
Groups and Group Processes; Organisational Culture; International Cultural Difference; Motivation; Stress; Organisational Politics; Leadership; Organisational Structures; Communications; Appendix: McGregor's Theory X and Y

subset: commoncrawl


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Today we drove back down to cañon city where we first went to new horizons thrift store. The we went to Jeff and Joanna smokers where the kids hung out for the afternoon while the adults went on a tour of new horizons ministry. Then we drove to ...
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... br> We saw where we are going to be rafting and saw a lot of rafts and kayakers on the river. There are remnants of mining and we hope that our rafting guide will know the history of the area. While we were there, a train tour passed by right along the river. The dogs enjoyed the romp in the wilderness too.
We started our � day raft trip through the Royal Gorge at about 1:00. We had to wear helmets ...
Beautiful day
... are fast and cold.
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Day 17 Brian's Awareness Tour
... I had about a 7 mile downhill ride into town which was a good way to end the day. An ever better way to end the day is Dairy Queen which I instantly spotted from across town. Tomorrow my goal is to get to Falcon which is about 65 miles from Canon City. Today I rode 58 miles. Not my best day but progress is ...
A little rain makes a lot of mud!
... the marvel of the day" was dug under the mountain to
carry part of the Gunnison River out into the Uncompahgre Valley.
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( http://www.nps.gov/blca/index.htm
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Wait 'til the banksters foreclose on the U. S. Thanks to their stooges that have sat in the White House and the political prostitutes that operate in the Congress. They have knowingly and deliberately hocked this whole nation. Their motto is; "After us, the flood."


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Traveling the Blackhills
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View at the top!
... wondering where his parents might be I was still able to get this photo. I mounted-up, rode downhill and away! From the next promontory I looked back in time to see a Ram step out on the point of that same bluff. My headache didn't go away after that but I didn't notice it nearly as much! Sorry that these posts are coming so close together but when the internet is hot I must strike!
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... River where Interstate 90 crosses
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text:
A bill to tighten controls on the way federal websites capture user information won approval from the House Oversight and Government Reform Committee on March 13.
The measure would require any federal website that collects personally identifiable information from users -- including name, date of birth, Social Security number, or financial information -- must be certified as safe and secure by the agency CIO before going live.
Agency and contractor personnel with access to personal information would have to sign a non-disclosure agreement specifically covering personal data. Additionally, government agencies would be required to take "reasonable efforts" to secure multiple domain registrations to avoid confusing site visitors. For example, the bill envisions a site such as HealthCare.gov also being available at HealthCare.com and HealthCare.org.
"When entering their personal information on a federal website, Americans should have the peace of mind that it will remain private, safe, and secure from hackers," said the bill's sponsor, Michigan Republican Rep. Kerry Bentivolio.
The bill also includes an amendment from Rep. Gerry Connolly (D-Va.) that would require agencies to notify individuals whose information may have been disclosed in a security breach within 72 hours of the incident, and to report breaches to a federal cybersecurity center.
The committee also approved a bill to end the requirement that the Government Printing Office physically print the Federal Register, while easing constraints on how agencies submit notices to the GPO for inclusion in the Federal Register.
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Adam Mazmanian is FCW's executive editor. Connect with him on Twitter: @thisismaz.
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The federal government craves more cybersecurity professionals. These six schools are helping meet that demand.
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El Paso, TX (PRWEB) August 13, 2013
Online USA Doctors is pleased to announce the first type of health insurance alternative option plans giving people unlimited doctor access.
A team of USA licensed, educated doctors working under Dr. Shelton, medical director and providing care nationwide are collaborating to close a huge gap in health insurance options through OnlineUSADoctors. This is in line with President Obama's call that everyone is treated equal and timely with USA doctors providing care in numerous ways, such as telemedicine which allows doctors to consult and treat patients using video conferencing.
What makes their new way of providing medical care different is the equilibrium between traditional medical science, and the more subtle approach that a medically qualified doctor provides. Add the fact that they deliver their medical diagnosis in a virtual environment (online/video conference/telephone) called telemedicine. This has become the obvious health insurance option for many.
Online USA Doctors offers a dynamic approach to same-day medical concerns and problems that often send people seeking urgent care services.
Dr. Shelton and the team of doctors at Online USA Doctors have successfully bridged the gap that other telemedicine websites and services have faced, by successfully implementing a comprehensive self-diagnostic tool. Their extensive questionnaire analyzes all core dimensions of being human, providing the clues doctors need to understand patients' underlying health conditions best within the dictates of scientific medicine.
"We decided to give this t
|Source: PRWeb
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Sutton Library Fire Exits
3.17pm Wednesday 10th March 2010
A investigation into fire escapes at Sutton Library revealed residents' lives were being put at risk because a fire exit on the ground floor was locked. On Friday evening a concerned resident secretly made this film, clearly showing the locked fire exit. This is against the law and as a result Fire Safety Investigation Officers called to the library on Monday forced library staff to unlock the escape door and ordered an investigation. Fire officers said locking this fire door was not in breach of regulation. The officers said this fire exit door must remain unlocked.
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There's a New Underwear Line That Filters the Smell of Your Flatulence?
We've seen underwear before that claims to filter out the smell of your flatulence, but they're always bulky and the reviews say they're only sort-of effective.
We've seen underwear before that claims to filter out the smell of your flatulence, but they're always bulky and the reviews say they're only sort-of effective.
Smartphones are an essential part of our lives. They're also an essential part of our mornings.
If the shutdown drags on, a lot of Hanford workers could have nothing to do.
I read a disturbing news story regarding the government website for the affordable health care act. John McAfee the creator of McAfee virus protection said the government website is wide open for hackers to steal you identity. Check out his interview on the Fox News channel...
The new iPhone has only been out a few days, but the one thing everyone seems to be doing is testing the camera's new slow-motion feature.
The new iPhone 5S comes with a built-in biometric scanner that lets you unlock it with your fingerprint. But that's not the only body part you can use to unlock your phone.
Keyw.com is now mobile! You live a mobile life, and now it's possible to stay connected to 98.3 The Key wherever you go. Our new mobile website makes everything you love about keyw...
On Tuesday, Apple unveiled the newest iPhone, and the biggest new feature is a built-in fingerprint scanner. It only unlocks your phone when it detects your fingerprint touching the button.
Apple unveiled two new iPhones, the 5S and the 5C, on Tuesday afternoon, in addition updates to iTunes and its mobile operating system, iOS. Here's what's new (updated with pictures from the presentation below):
Landlines are going the way of phone books.
To show how realistic their high-def TV's are, LG Electronics set up a bunch of job interviews in Chile, and covered an entire window of the interviewer's office with an 84-inch television.
Telling time is something we all do, usually everyday. How you go about telling time is a different matter. Some folks opt for a clock on their cell phone or a simple watch, while other spend thousands of dollars on an expensive Rolex.


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editor's review
1 comment
Not many people rely on the Favorites folders in Windows simply because they typically do not link to the directories they access the most often. Even if this list can be customized, many prefer to rely on third-party launchers to quickly navigate to files and folders.
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Originally Posted by Christopher Walrath
The seller does admitin the fine print that they cannot test it and the consignor cannot say that the camera is fine so it is being sold as-is. But that's kinda buried. Not really on the deceptive side unless it has been changed since this thread was started.
But the photo in the listing is definitely deceptive. An honest seller would put up a photo that truly represented, to the best of their ability, the condition of the item. This seller would definitely get completely negative feedback from me, plus would have a dispute lodged. This listing is not honest and IS deceptive.
^ I'd have to agree with Lyle. It's the same as someone advertising a car
and showing a picture of it in profile and when you arrive you see that the
other side of the car is smashed.
I don't think this seller intentionally set out to be deceptive but that won't
do much to calm the poor buyer who buys this piece of junk.
Arghhh, I'm angry and I haven't even bought the thing or placed a bid (not that I will).
Funny thing is that the seller has a 100% rating and 5,000 sold. Obviously this guy has some tricks up his sleeve to quiet the occasional disgruntled buyer.
That's the shitty thing about ebay (and anywhere else for that matter): a small number of crooks messing things up for a majority of honest people. And the pro-crooks getting away with their crookeries, of course.
It's impossible that you put up such an auction and not know that you are pulling legs. This guy *is* a crook.
I like the description of "focus type"-manual and automatic. Hmm... autofocus Retina.... hmmm.......
I orta git it, soze I kan haz a one-r-a-kind. I always wanted an autofocus cam.
In general, I don't like buying from these "consign" type locations. They either have no clue about what they are selling or can pretend to.
But this situation is a bit different - this is an antique dealer who can be reasonably expected to accurately describe the external physical condition of an item. To say nothing in the description of mold, corrosion, and covering lifted off, and to include a photo that hides those, is deceptive. In the case of an antique dealer, you'd have to assume it's intensionally deceptive.
The seller can't hide behind protestations of not knowing technical condition or not being a camera expert - it's basic common sense.
At this moment there are 3 bids on the item. It will be interesting to see what,
if any, feedback ends up being posted on this transaction.
I'm watching the item, very interested in the final sale price.
Originally Posted by ralnphot
I like the description of "focus type"-manual and automatic. Hmm... autofocus Retina.... hmmm.......
I orta git it, soze I kan haz a one-r-a-kind. I always wanted an autofocus cam.
It also says the color is black. I didn't notice that before. If this really were a
black Retina Reflex that would be a find in itself but, of course, it isn't.
So, the seller is advertising a moldy junked camera with misrepresented
condition and falsely saying it's black and auto-focuses!
As to the Canon case, they are often found in that condition even if the camera is in fine shape.[/QUOTE]
My point.
John, Mount Vernon, Virginia USA
Having seen this thread, I contacted the seller and they added the extra photos to their listing. I'm not sure why some people have a fascination with badly described ebay listings. If people see something odd, why not do everyone a favour and contact the seller about it.


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CNET brings you the best deals on tech, gadgets, appliances and lifestyle products every day. For great offers and exclusive deals on smartphones, tablets, cameras, appliances and more, find your discount here.
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Third-quarter financial results show the Taiwanese smartphone maker struggling both with the big names and the upstart Chinese device makers.
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Sprint and T-Mobile each announce what look like incredibly cheap pricing for the new iPhone 6S and 6S Plus. What's the catch?


text:
I went to Mazatlan for the 2007 Carnival festivities; I had no reservations for any hotel. When I stopped at the Playa Marina Hotel and asked if they had any rooms available for the following Sunday carnival's parade. The front desk clerk informed me that they only had a package deal for a 4 night minimum if I wanted to get a room with a balcony. He also told me that in order to get the room for this dates I would have to talk to their reservations department. I was directed to the reservation office and I was informed that in order to get a room with a balcony I would have to pay the full amount in advanced. I asked for someone in reservations to show me the room and after seeing it, I agreed to pay $8850.00 Mexican pesos (Abouth $830.00 US Dollars) For the stay in 5th floor the suite witch I was told by the hotel staff had a very good view of the Carnival's parade, Further more I was ensure that of possible I would be moved to a lower floor suite to have a better view of the parade. The day of the parade 2hrs before it begin I received a call from the front desk manager telling me that my room had expired and I either pay $1100.00 Mexican pesos (About $100.00 US Dollars) more or I had to vacate the room in 30 min. I demanded to speak to the person I did the reservation with or with the hotel manager to who they told me were not in that day. The only option given was to accept the charges and talk to the manager the next day after 11: AM for a possible refund. I explained to the front desk manager that my flight would be Sunday night. After getting kick out of my room two hours before the parade, the balcony was occupied within 10 minutes by other guest. The next day I call the reservations office, after explaining the situation they apologize very deeply for their "Mistake" and proceeded to explain to me that I can not get any portion of the money I paid back. I tried unsuccessfully to reach the general manager for several days. Tired of many promises of the general manager returning my call I proceeded to dispute the partial amount in my credit card. Unfortunately my plans of watching the parade from a hotel balcony were ruin by the lack of good customer service in this hotel. And no money back would solve this disappointment.
- Reservation Options:
- TripAdvisor is proud to partner with Expedia, Travelocity, TripOnline SA, Low Cost Holidays and Hotels.com so you can book your Hotel Plaza Marina Mazatlan reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.


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Our job is to make sure government and other public bodies protect the human rights of everyone in Northern Ireland. We also help people understand what their human rights are and what they can do if their rights are denied or violated.Read More →
|Treaty and International Work
|Human Rights Annual Statement
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Response to the Health and Social Care (Control of Data Processing) Bill. - Advice to government
Response to the Committee for Environment's consultation on the Environmental Better Regulation Bill - Advice to government
Response to Home Office Consultation on Reforming Support for Failed Asylum Seekers - Advice to government


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Reviews - The Buck Inn3
The Buck Inn, ,, Malham, BD23 4DA
Price FromView Rooms
Customer Reviews
Our reviews are from genuine LateRooms.com customers. We verify that the customer has stayed before leaving a review.
Very Good
97% would recommend it to a friend
Customer service
Food quality
Room quality
The management were very helpful when I pointed out the noise in my room.They very kindly moved me to another.So there was not a problem.
Buck inn
Welcoming from moment we arrived, lovely bar/ restaurant, friendly people,accommodating , good food, room 9, shower pressure a little weak other than that loved it would go back
Helpfull staff
Really enjoyable stay staff very friendly and helpfull food great
Anniversary night away
Nice room with very comfy bed
Food excellent
room acceptable, meals nice,staff friendly.
enjoyed my stay, nice open fire to keep warm, locals friendly as well.
Christmas time
Everything was excellent, good interesting food at resonable price.
Homely atmosphere in front of log fires. Superb real ales. Welcoming hosts.
Read More Less
Lovely country inn pleasant bar staff excellent cask ales.
Breakfast was superb
Read More Less
Weekend walking break
Bed in need of a new mattress , had to pack sides up with pillows as it felt like we were rolling out of bed, but all in all we had a good stay at The Buck Inn, food good, staff very good.
Perfectly situated to explore the Dales and on doorstep of a number of the Dales iconic sites.Friendly staff and a great menu for hungry tourists.
Great food, basic room
We had a lovely stay at the Buck Inn for a couple of days over half term.
The room was clean but basic, and the bed was a little lumpy but not too much of a problem. We ate in the Pub both nights and the food was fantastic, as was the very well kept beer. The food, drink and atmosphere of the Buck are it's true selling points. We would recommend and go again.
Read More Less


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"21-Bottle Trellis Wine Rack" is not available for sale online.
This item may be discontinued or not carried in your nearest store. Please call your local store to check in-store availability before heading there. For informational purposes, the product details and customer reviews are provided.
- 21-bottle capacity.
- Measures 29 1/2" H x 16" W x 16 3/4" D.


text:
Montana Boca United have appointed Vivian Emanuel as their new manager for next season.
The club operated under chairman Raymond Harrod who along with Adam Osper, worked as caretaker-managers following the departure of Marc Ziedman. They finished sixth in Division One last season.
Emmanuel joins the club following a stint at Pinner JFC in Division Four.
A looping header from goal-poacher Mark Morris saw London Maccabi Lions win the Nathan Horwitz MMFL Division 2 Cup following a hard fought 1-0 win over EDRS Stonegrove.
A match of few chances at Barnet FC saw the deadlock broken just before the interval however when Morris was reached a cross from Stuart Coutts' to place a header into the top corner.
A last-ditch effort from hotshot Mark Wagman saw Brady Maccabi A complete a third consecutive league and cup double as they came from behind to beat Faithfold 2-1 at Underhill.
Faithfold were beaten on penalties at Oldham Athletic's Boundary Park as Manchester Maccabi lifted the Peter Morrison Trophy.
Defences dominated throughout with neither team able to break through in 120 minutes of open play.
Avram Grant has left West Ham following Sunday's 3-2 defeat at Wigan Athletic which sealed their relegation from the Premier Division.
The Hammers threw away a 2-0 lead to become the first team to go down from the top-flight this season.
"Avram Grant is no longer the manager of West Ham United," a statement said.
Manchester Maccabi lifted the Peter Morrison Trophy after beating on penalties while Inter Borehamwood clinched the JC MSFL Division Four title.
PMT - Manchester win cup final shootout
Div 4 - Borehamwood clinch title after five-goal thriller
Joe Jacobson has set his sights on finishing an excellent season by leading Accrington Stanley to playoff glory.
The 24-year-old, who signed a permanent deal with the League Two club last January following a successful loan spell, has been an integral part of John Coleman's side.
Ben Winston has been forced to make two changes to his Maccabi GB Open football squad competing at the European Maccabi Games in Vienna.
Faithfold midfielder Paul Babai replaces teammate Alex Levack while Jake Gottlieb makes way for Neasden colleague George Fierstone.
An extra-time double from Daniel Rose helped HMH come from behind to win the John Rubens Cup.
The Under 16 final at Rowley Lane looked set to go Manchester Maccabi's way as they forged into a 3-1 lead.
Inter Borehamwood have taken the Division Four title race to the last weekend of the season following an 8-2 win over Los Blancos.
Adam Newman (3), Ben Zelouf, Joe Levy, Joel Lassman, Jerome Colmans and Richard Winton were the marksmen.


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Town Square
Duct Tape Wallet Craft at Atherton Library
Original post made by Atherton Library, Atherton: other, on Nov 3, 2009
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DeBlasio Leading in NYC Mayoral Primary
NEW YORK -- Public Advocate Bill de Blasio held a clear lead Tuesday night in New York City's mayoral Democratic primary as polls closed, according to early and incomplete voting returns. It was unclear, though, whether he would top the 40 percent threshold needed to avoid a runoff.
De Blasio's rise in the race to succeed Mayor Michael Bloomberg was as sudden as it was unexpected.
Not even two months ago, he was an afterthought in the campaign but surged in part thanks to an ad blitz that centered on his interracial family, his headline-grabbing arrest while protesting the possible closure of a Brooklyn hospital and the defection of ex-congressman Anthony Weiner's former supporters in the wake of another sexting scandal.
With 87 percent of precincts reporting, de Blasio has about 39.6 percent of the total vote. Former city Comptroller Bill Thompson has 26 percent, and City Council Speaker Christine Quinn has 15 percent. They were followed by current city Comptroller John Liu at 7 percent and Weiner at 5 percent.
Exit polling showed the appeal of de Blasio, the city's elected public advocate, to be broad-based: He was ahead in all five boroughs; was ahead of Thompson, the only African-American candidate, with black voters and ahead of Quinn, the lone woman in the race, with female voters. He also led Quinn, who is openly gay, among gay voters.
The voter interviews were conducted by Edison Media Research for The Associated Press and other news organizations.
If no candidate surpasses 40 percent of the vote, the top two finishers advance to an Oct. 1 runoff.
The winner of that contest will face the Republican nominee Joe Lhota in the Nov. 5 general election. Lhota, ex-MTA chairman and former deputy mayor to Rudolph Giuliani, defeated billionaire grocery magnate John Catsimatidis for the GOP nomination.
In the closely watched race for city comptroller, exit interviews show Manhattan Borough President Stringer running ahead of ex-Gov. Eliot Spitzer, who was seeking a return to politics after resigning New York's governor's office in 2008 amid a prostitution scandal.
The winner of the mayor's race in November will assume the helm of the nation's largest city at a critical juncture, as it experiences shrinking crime rates yet widening income inequality, and as the nearly completed One World Trade Center building symbolizes a new era after the terrorist attacks of 2001.
Bloomberg, the businessman Republican-turned-independent, is completing his third term. While the city's registered Democrats outnumber Republicans 6 to 1, the GOP's recent success in mayoral elections has been largely attributed to a crime epidemic, the aftermath of the Sept. 11 attacks or other extraordinary circumstances.
Nearly three-quarters of Democratic primary voters say the next mayor ought to move away from Bloomberg's policies, according to the exit polls.


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Early Season Heisman CandidatesThere are still two full months left in the college football season, but already the Heisman Trophy picture has vastly changed since the pre-season, and as October begins, there are already leaders in the clubhouse to lift college football's most prestigious award.
5 NFL Games You Can't Miss This Week (Week 4)Here are some of the best games in Week 4 as we approach the quarter pole of the NFL season.
The 2003 Football Huskies - A Forgotten Team ?
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UCONN Football Picked Last In AAC Division Cincinnati has been picked as the favorite to win the American Athletic Conference's inaugural football championship game.
Top 5 Most Dangerous SportsRhythmic gymnastics and table tennis just missed the cut.
Uconn Football Player Charged With Assault
Who Is Ted Wells? 4 Things To Know About The "DeflateGate" InvestigatorTed Wells. Have you heard of him? If you haven't, you might want to make yourself familiar with him because he might be the single-most important person in the NFL right now.
New Offensive Coordinator For Football Huskies
Auburn, UCLA And USC Win Big On National Signing DayNational Signing Day is arguably the most important day of the college football year.
A Lot Of Positives, Some Questions For Steelers As Season Comes To A CloseThe Pittsburgh Steelers finished the 2014 regular season as AFC North champions, but sputtered in the wild card round of the playoffs. With the Pittsburgh Steelers' season coming to a close after a playoff loss to the Baltimore Ravens, it's time to reflect on the positives and negatives from their 2014 season.


text: Gillian's Past Matt Richenthal at October 27, 2013 8:58 am. Comments A secret about Gillian's past is uncovered on the episode "Sweet Sixteen." This clips gives us an idea of what that is. Share Tweet Email Edit Delete Follow Lie to Me Show: Lie to Me Episode: Lie to Me Season 2 Episode 12: "Sweet Sixteen" Related Videos: Lie to Me Videos, Lie to Me Season 2 Episode 12 Videos Uploaded by: Matt Richenthal Uploaded: October 27, 2013


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BETHESDA, Md., Nov. 10 /PRNewswire-FirstCall/ -- Spherix Incorporated (Nasdaq: SPEX) reported that the Nasdaq Stock Market has approved its application to transfer the listing of its common stock from the Nasdaq Global Market to the Nasdaq Capital Market. The common stock is expected to commence trading on the Nasdaq Capital Market on November 11, 2008.
The Nasdaq Capital Market is one of three market tier designations for Nasdaq-listed stocks, and presently includes over 550 companies. Spherix's trading symbol will continue to be "SPEX". Securities listed on the Nasdaq Capital Market must satisfy all applicable qualification requirements for Nasdaq securities and all companies listed on the Nasdaq Capital Market must meet certain financial requirements and adhere to Nasdaq's corporate governance standards. Spherix applied to transfer to the Nasdaq Capital Market to conform to the continued listing requirements of Nasdaq.
Spherix continues to have until April 23, 2009 to achieve compliance with Nasdaq's $1.00 per share minimum price requirement. A special meeting of the stockholders of Spherix will be held on November 17, 2008 to vote on a proposal to authorize a reverse stock split of the common stock within a range of 1:5 to 1:20. If approved, the Board of Directors will have the authority to determine, in its discretion, the actual ratio of the reverse stock split and when and if such reverse stock split should be implemented. The Board would have the authority to implement the reverse stock split at any time within twelve (12) months of the special stockholders meeting.
Certain statements contained herein are "forward looking" statements as
defined in the Private Securities Litigation Reform Act of 1995. Because
|SOURCE Spherix Incorporated
Copyright©2008 PR Newswire.
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The Resort at The Mountain
Welches, ORof 610 reviewsThe only premier Oregon full service mountain resort offering golf, ski and meeting services
- $152
- avg/night
The Resort at The Mountain
Nestled in the western highlands of Mt. Hood, less than an hour from Portland, is one of the Northwests premier destination resorts. The 157-room Resort at The Mountain, with its unique ambiance and exceptional service, complements the natural beauty of neighboring national forests and clear running streams. Here, guests of all types groups, couples and families may choose from a seemingly endless array of seasonal activities and adventures. Tee it up on the 27-hole championship golf course (The Courses) or play the 18-hole putting course (The Greens). Serve it up on a tennis, volleyball or badminton court. Roam picturesque grounds. Salmon fish. Pick berries and forage mushrooms. Hike. Photograph wildlife. Take off on a mountain bike. Work out in the fitness center. Then chill out around the pool. Or indulge all your senses at The Resorts full-service spa.
Winter getaways are special as well. Guests may ski or snowboard to their hearts content at one of three Mt. Hood ski areas. And end their day basking in the warmth and glow of one many fireplaces at The Resort, while contemplating tomorrow. There is so much more to see and do in and around the Mt. Hood Territory. Visit local farms and flower gardens. Or historical museums. Tour and taste at area wineries and micro-breweries. Much depends on the season.
Come experience the breathtaking beauty of Mt. Hood and the warmth and splendor of The Resort at The Mountain!
- ATM/Cash Machine
- Babysitting
- Bar/Lounge
- Basketball Court
- Bicycle Rentals
- Business Center
- Cable/Satellite Television
- Children's Activities
- Complimentary Newspaper
- Complimentary Parking
- Croquet
- Dry Cleaning/Valet Laundry
- Fishing
- Fitness Center
- Front Desk Open 24 Hours
- Gift Shop
- Golf Course
- Golf/Pro Shop
- In-Room Coffee Makers
- In-Room Fireplaces (Some Rooms)
- In-Room Flat Panel Televisions
- In-Room Hairdryers
- In-Room Irons & Ironing Boards
- In-Room Safes
- Jacuzzi/Hot Tub
- Meeting Facilities
- Non-Smoking Rooms
- Pet Friendly
- Playground
- Pool (Outdoor Seasonal)
- Putting Green
- Refrigerators (All Rooms)
- Restaurant(s)
- Safety Deposit Boxes
- Skiing/Snowboarding
- Spa
- Tennis
- Volleyball Court
- Wi-Fi
- Check In: 4:00 PM
- Check Out: 12:00 PM
Resort Fee: $12.00A $12 daily resort fee will be collected by the hotel upon check-out. This fee is in addition to the room rate and tax and is not included in your online reservation total. It includes 24/7 access to Business Center; guest room internet and local calls; use of sports equipment, 18-hole putting course, casual croquet lawns, lawn bowling, tennis rackets and balls, mountain bikes, volleyball, football, and badminton sets, backgammon, chess, checkers, poker chips and games; use of Fitness Center; coffee, hot chocolate, tea in lobby 6 AM - 5 PM daily; USA Today newspaper Mon - Fri and local paper on Sunday; self parking.
- Rollaway: $20.00
- Pet Policy: A limited number of canine-friendly rooms are available. A one-time per stay, $50 per pet fee, a maximum of two dogs of up to 50 pounds each.
The Resort at The Mountain
Nearby hotels
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Brad Keselowski dominates at Bristol
Updated: March 18, 2012, 8:39 PM ETAssociated Press
BRISTOL, Tenn. -- Brad Keselowski used Bristol Motor Speedway last fall to cement his spot in NASCAR's championship race.
Back at the track Sunday, Keselowski again made his way to Victory Lane.
And he again began to think about a Sprint Cup title.
Keselowski led a career-best and race-high 232 laps, then held off Daytona 500 winner Matt Kenseth on a late restart to cruise to his first victory of the season.
"What can I say? I love Bristol and Bristol loves me," ...
Read full story
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Unlike a sand witch, a sandwich doesn't have the power to turn men into sand and sand into poisoned glass. Let a sandwich cast a devastating spell on hunger pains with this Groupon.
$10 for Two Groupons, Each Good for $10 Worth of Café Food and Drinks ($20 Value)
The menu includes breakfast dishes such as a biscuit sandwich ($2), lunch selections such as a BLT ($5), and pastries such as cupcakes ($1.25) and donuts ($1).
Customers who go to the bakery starting at noon on Saturday, June 22, can visit its Strawberry Feast festival, with strawberry shortcake, a movie screening, and other activities.
Butternut Bakery
The bakers at Butternut Bakery craft darling cakes and cupcakes for celebrations, but the kitchen doesn't stop there. Patrons visit the homey eatery for breakfast, where they can order eggs any way they like them—except in a omelet with cotton candy. At lunchtime, sandwiches made with grilled chicken or bacon are whisked out to waiting customers, and housemade pastries round out meals with a sweet finish. On select Friday nights, prime-rib dinners bring the community together for a familial feast.
92% of 13 customers recommend
"Food was great and service was even better. Adorably, quaint atmosphere. Would highly recommend it."
"We enjoyed the home town atmosphere, food and people were super! We will return."
105 West Main Street
Morristown, IN 46140
+17657636140Get Directions


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Judge Dan
Latest posts by Judge Dan (see all)
- Arab Social Media Going On A Wild Goose Chase - August 2, 2015
- No, Israel Did Not Clear A Refugee Camp Inside Syria - July 13, 2015
- The World According To UNHRC Condemnation - June 25, 2015
- Terror-ble Palestinian Kindergarten Plays - May 27, 2015
- Gaza Kindergarten Play From Hell - May 24, 2015
This political satire was posted by The People's Cube in 2006, in response to the world's reaction towards Israel defending itself in the 2nd Lebanon war:
Europe 's view of the present Israeli offensive against Hezbollah as an "overreaction" and "disproportionate use of force" is rooted in relatively recent history, say progressive researchers. In 1943, Europe itself suffered from a similar Jewish overreaction to some controversial German policies, in an event known as the Warsaw Ghetto Uprising, when Zionist radicals attacked the National Socialist German Workers Party that was loved by the German people for its far-reaching educational and social welfare services. In fact, many academics who teach Peace Studies at prestigious universities believe that it was the Zionists' "disproportionate use of force" that had ruined hopes for peace in Europe and caused a humanitarian crisis that could have easily been avoided if only Jews had shown restraint and tolerance towards the democratically elected German government.
In fact, the reaction of world's media to the current Middle Eastern crisis is almost identical to that during the 1943 Warsaw crisis when, as modern historians claim, militant Zionists jeopardized the fragile peace that European leaders and progressive intellectuals had been trying to achieve by civilized means – as evidenced by the following collection of quotes and headlines of the time.
6 years later, it's as up-to-date as ever.


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Many property owners lose their right to challenge their real property tax assessment by ignoring the annual request by their local Tax Assessor to complete an Income and Expense Statement. This request is authorized by N.J.S.A. 54:4-34 and is known as a Chapter 91 filing. If you are served with a Chapter 91 request you must respond to same within the required time period otherwise the municipality can move to dismiss any subsequent tax appeal filed.
Please see full article below for more information.
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The Incredible Hulk: Season 3, Episode 9
The Snare (7 Dec. 1979)
David 'Bennet' is invited by a millionaire to play a game of chess on his private island. The man turns out to be a hunter and David becomes his prey, with his Hulk form making him even more an appealing challenge.
Director:Frank Orsatti
Writers:Kenneth Johnson (developed for television by), Richard Christian Matheson, 1 more credit »
Stars:Bill Bixby, Jack Colvin, Lou Ferrigno | See full cast and crew »


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New York
Welcome to the SMPTE-NY Section Website. Click HERE to contact webmaster Tim Dwight.
Click HERE to sign up for our eNewsletter.
There are 2 October meetings--
10/15/15 in Handen, CT
10/21/15 in Hauppauge, NY
Scroll down for details!
SMPTE-CT Subsection & SBE-14 Joint October Meeting
Thursday, October 15, 2015
"The Future of Wireless Microphone Operations"
Quinnipiac University, Hamden, CT.
6:00 PM Social hour and networking
6:45 PM Meeting starts
7:00 PM Presentation starts
8:30 PM Meeting ends
Produced by Brian Kobylarz
Presented by Joe Ciaudelli
The Federal Communications Commission (FCC) plans to repurpose spectrum from traditional overthe-
air TV to mobile broadband through its Incentive Auction, scheduled for March 2016. Pending its
success, a large portion of the upper UHF spectrum, specifically the 600 MHz band will become
unavailable to wireless microphones in about four years… sooner in some areas.
Joe will navigate through the recent FCC rulings essential for wireless microphone operators. Important
considerations are about half the existing UHF microphones are likely to be rendered obsolete or require
extensive modification. However, there will be pockets (guard bands and duplex gap) in the re-purposed
spectrum where mics will be allowed to operate but under different rules. The FCC will be opening
alternate bands to licensed microphone operators for shared use with other primary services.
About the Presenter
Upon graduating from Columbia University with an electrical engineering degree, Joe served in various
capacities at Sennheiser USA. A long recognized wireless audio industry expert, Joe provided frequency
coordination for large multi-channel wireless wireless used by Broadway productions, major theme parks
and broadcast networks.
Joe wrote the chapter on wireless microphones for the last three editions of the Handbook of Sound
Engineers. He will be a member of the U.S. State Department delegation for the World Radio Conference
this November in Geneva, Switzerland.
SMPTE-LI October 2015 Meeting
"Mobile Video Distribution"
Wednesday, October 21, 2015
Globecomm Systems Inc., Hauppauge, NY
Registraton REQUIRED by 6 PM on 10/16/15
Globecomm Systems Inc.
45 Oser Avenue
Hauppauge, NY 11788
5:30 – 6 PM social hour and networking
6:15 – 8:00 PM technical meeting
Nick Governale, Globecomm
Raymond Blumenthal, The Tiffen Company
Paul Scardino, Globecomm Systems Inc.
Guests and Non Members Welcome! Refreshments will be served!
Globecomm Systems provides managed network communication solutions to Government and Industry, including major broadcasters. They provide expertise in emerging communication technologies, including a comprehensive suite of system integration, system products, and network services enabling a complete end-to-end solution for their customers. Nick Governale, Prinicpal Engineer of Globecomm, will walk us through two particularly complex delivery schemes that were developed for end-users in very different business segments.
Major US Broadcaster's Network Case Study –
Presenter: Nick Governale, Globecomm
Globecomm recently completed a hybrid contribution network linking the major broadcaster's hub(s) with its affiliate stations across the US for the cost-effective sharing of content via satellite, the Internet and the cloud. The network fulfills their ambitions to enhance the quality and flexibility of audio and video contribution while sharply reducing its cost and simplifying the work of staff at nearly 200 member/affiliate stations.
Rollins/Orkin Business TV Case Study –
Presenter: Globecomm TBD
Rollins/Orkin produces a tremendous amount of live job enhancing material each week, from their studio. These broadcasts are delivered to multiple devices through the cloud in their network for consumption as live interactive sessions, and as on-demand content that is accessible by company provided mobile devices. The success of this network can be attributed to the management of the IP components provided by MPEG4 - h.264 video and the use of IP multicasting (via a private MPLS network.)


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Journal of Small Business Strategy
General Business Journals 17 issues, 118 articles
The semiannual journal publishes applied research on topics related to entrepreneurship, small business, and community development
General Business Journals 17 issues, 118 articles
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Suzuki GSXR600 (GSX-R 600, GSX-R600)
A 600 with a champion heritage. Leading the class is one thing. Leaving it far behind is another. The GSXR600 features a lightweight chassis, race-developed suspension and a compact, powerful 4-cylinder engine delivering a real-world demonstration of advanced race-proven technology. The 600 gixer's goal is winning. The plan, overwhelm the would-be competition and establish domination. The GSX-R600 is designed to be The Top Performer in its class, a total package designed to Own the Racetrack. A 600 like no other!
, Derbyshire
UK - England & Wales
+44 (0) 1629 584394
© 2015 moto-racing.co.uk
All rights reserved worldwide


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STARmeterSEE RANK
Up 300,224 this week
Jeff Horny
Jeff Horny is an actor and producer, known for I Woke Up Early the Day I Died (1998), Rebirth (1999) and Behind the Confessions: The Life, the Music and the Revival of Radney Foster (2009). See full bio »
More at IMDbPro » Contact Info: View agent
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York Dolls House & Miniatures Fair (Winter)
Show HomeFeatures & DisplaysExhibitorsBooking
Sunday 22nd November, 2015
York Racecourse, York, YO23 1EX
York Racecourse, York, YO23 1EX
Ticket pre-booking closes at 9am on 13 November 2015. Please note that tickets are non-refundable, non-exchangeable and we regret lost tickets cannot be re-issued.
For any queries regarding ticket bookings please email firstname.lastname@example.com or call 01778 391123 (Monday- Friday, 9am - 5pm).
Show Opening Hours
Sun 10.30am- 4.00pm.
Doors open at 10.00am for pre-booked ticket holders
All admission letters will be dispatched in time for receipt before the Fair. Only contact us if you haven't received your letter two days prior to the Fair.
Disabled Ticket Policy
We do not wish to discriminate against visitors with disabilities, so the full admission rate will be charged. However, if a visitor has a full-time carer or attendant, a free ticket is available for them at the time of purchasing a standard price visitor ticket. This concession is only available by applying in advance, with supporting documentation to the office. All documentation must be received at least 2 weeks prior to the show.
Pricing Details
Sunday Tickets
|On Door