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The photosensitive molecule rhodopsin and its relatives consist of a protein moiety - an opsin - and a non-protein moiety - the chromophore retinal. Opsins, which are G-protein-coupled receptors (GPCRs), are found in animals, and more than a thousand have been identified so far. Detailed molecular phylogenetic analyses show that the opsin family is divided into seven subfamilies, which correspond well to functional classifications within the family: the vertebrate visual (transducin-coupled) and non-visual opsin subfamily, the encephalopsin/tmt-opsin subfamily, the Gq-coupled opsin/melanopsin subfamily, the Go-coupled opsin subfamily, the neuropsin subfamily, the peropsin subfamily and the retinal photoisomerase subfamily. The subfamilies diversified before the deuterostomes (including vertebrates) split from the protostomes (most invertebrates), suggesting that a common animal ancestor had multiple opsin genes. Opsins have a seven-transmembrane structure similar to that of other GPCRs, but are distinguished by a lysine residue that is a retinal-binding site in the seventh helix. Accumulated evidence suggests that most opsins act as pigments that activate G proteins in a light-dependent manner in both visual and non-visual systems, whereas a few serve as retinal photoisomerases, generating the chromophore used by other opsins, and some opsins have unknown functions.
Opsins are membrane proteins with molecular masses of 30-50 kDa that are related to the protein moiety of the photoreceptive molecule rhodopsin; they typically act as light sensors in animals [1-4]. Photoreceptive proteins similar to the animal opsins in three-dimensional structure but not in amino-acid sequence have been found in archaea, bacteria, fungi, and a green alga, Chlamydomonas reinhardtii [5,6]. These non-animal opsins function as light-driven ion pumps or light sensors but there is no evidence that they are structurally related to animal opsins, so they are not considered further here.
Since the first sequence of an opsin, bovine rhodopsin, was determined by conventional protein sequencing in 1982 [7,8] and cDNA sequencing in 1983 [9], more than 1,000 opsins have been identified. The molecular phylogenetic tree shows three large clusters, and detailed analyses have revealed that the opsin family is divided into seven subfamilies; there is less than about 25% amino-acid similarity between subfamilies but more than about 40% among members of a single family (Figure (Figure1).1). The division into subfamilies corresponds well to functional classification of opsins, which is based partly on the type of G protein coupled to each of these G-protein-coupled receptors (GPCRs). The seven subfamilies are as follows: the vertebrate visual (transducin-coupled) and non-visual opsin subfamily; the encephalopsin/tmt-opsin subfamily; the Gq-coupled opsin/melanopsin subfamily; the Go-coupled opsin subfamily; the peropsin subfamily; the retinal photoisomerase subfamily; and the neuropsin subfamily. Members of the Gq-coupled opsin/melanopsin, Go-coupled opsin, encephalopsin/tmt-opsin and retinal photoisomerase subfamilies are found in both deuterostomes (such as cephalochordates and vertebrates) and protostomes (such as molluscs and insects; Figure Figure1),1), suggesting that diversification of the subfamilies occurred much earlier in animal evolution than the deuterostome-protostome split [10].
The visual and non-visual opsin subfamily contains vertebrate visual and non-visual opsins. The visual opsins can be further subdivided into cone opsins and rhodopsin, which have distinct molecular properties arising from differences in the residues at positions 122 and 189 of the amino-acid sequence [11,12]. The cone opsins can be further divided into four subgroups, which correspond well with their absorption spectra: long-wavelength opsins (LW or red), short-wavelength opsins (SW1 or UV/violet and SW2 or blue), and middle-wavelength opsins (MW or green; see Figure Figure1)1) [1,3,13]. Note that other nomenclatures are also used to specify these four groups. Most vertebrates, including the lamprey [14], have four kinds of cone-opsin genes, whereas mammals lack the SW2 and MW genes. Interestingly, humans have regained the green-sensitive opsin by duplication of the LW gene, so the green cone opsins of humans and lower vertebrates belong to different opsin subgroups (LW and MW) [15,16]. In the human genome, the red and green opsin genes are localized in tandem.
Lower vertebrates, including lampreys, have several non-visual opsin genes that are members of the same subfamily as the vertebrate visual opsins. The first non-visual opsin to be discovered was pinopsin [17], which is involved in photoreception in the pineal organs of birds [17,18] and lizards [19]. Parapinopsin was first found in the pineal complex of the catfish [20], and it has also been found in zebrafish and Xenopus and more recently in the lamprey pineal [21]. 'Vertebrate ancient' opsin (VA-opsin) was first found in the salmon retina [22]; the lamprey also has an ortholog of VA-opsin, called P-opsin [23]. The ascidian chordate Ciona has an opsin (Ci-opsin1) that is closely related to the vertebrate non-visual opsins [24].
Within the other six subfamilies of opsins, members of the encephalopsin/tmt-opsin subfamily were first found in mouse and human [25], and homologs were recently identified in the teleosts [26] and interestingly in invertebrates, the mosquito Anopheles [27] and the marine ragworm Platynereis [28]. Phylogenetic analysis shows that encephalopsin/tmt-opsin subfamily probably clusters most closely with the vertebrate visual and non-visual opsin subfamily (see Figure Figure1).1). Melanopsin is an important vertebrate non-visual opsin, but because it is more similar in amino-acid sequence to invertebrate Gq-coupled visual opsins, it is not classified as a member of the vertebrate visual and non-visual opsin subfamily (see Figure Figure1);1); melanopsins have been found in many vertebrates, from fish to humans [29,30]. Members of the Go-coupled opsin subfamily have been found in molluscs and in the chordate amphioxus [10,31] but not in human, mouse, zebrafish or Drosophila. Neuropsins, recently identified in mouse and human [32], are phylogenetically distinguishable as a subfamily but little is known about them. Peropsins are known from a range of vertebrates, from fish to human [33], and an ortholog was recently found in amphioxus [31]. Finally, members of the retinal-photoisomerase subfamily, which includes retinal G-protein-coupled receptor (RGR) and retinochrome, are found in vertebrates and molluscs [34,35]; an RGR homolog has also been found in an ascidian [36].
The gene organization of different vertebrate opsins provides further information about relationships among the subfamilies [32,37,38]. The numbers of introns in the human opsin genes are shown in Table Table11 as an example. Three of the four or five introns in the vertebrate visual and non-visual opsin genes are shared at conserved positions with encephalopsin/tmt-opsin genes, consistent with the close relationship between these subfamilies found by phylogenetic analysis. The peropsin, retinal photoisomerase (RGR) and neuropsin subfamily genes have six introns, which are at positions different from those of vertebrate visual and non-visual opsin genes. Two and three of the peropsin introns are conserved in the RGR of the retinal photoisomerase subfamily and the neuropsin gene, respectively, again confirming a close evolutionary relationship between these subfamilies. The melanopsin gene has nine introns at positions different from those of other opsin genes.
Recent genome studies have also provided us with information on the loss of opsin genes during animal evolution. No opsin gene has been found in Caenorhabditis elegans [39,40]. Drosophila has seven opsin genes, all of which belong to the Gq-coupled opsin/melanopsin subfamily [41]. In comparison, humans have nine opsin genes (Table (Table1),1), which are spread over six of the seven subfamilies (Figure (Figure1).1). A PCR study [31] revealed that amphioxus has at least six opsin genes from four subfamilies (Figure (Figure1);1); deuterostomes therefore appear to have opsins from more subfamilies than do protostomes.
Opsins share several amino-acid motifs, including seven transmembrane helices, with other G-protein-coupled receptors (GPCRs) of the rhodopsin superfamily. The first primary sequence of a member of the rhodopsin superfamily, the β-adrenergic receptor, was determined in 1986 [42], and since then, the opsin family has been considered one of the typical members of the superfamily. As shown in Figure Figure2a,2a, several amino-acid residues are highly conserved among the opsin family members; about half of these are conserved in all GPCRs of the rhodopsin superfamily [43]. All opsins bind a chromophore: the vertebrate visual and non-visual opsins, the invertebrate Gq-coupled opsins, and the Go-coupled opsins all bind 11-cis-retinal, whereas the photoisomerases and the peropsins bind all-trans-retinal (Figure (Figure2b).2b). The chromophores of the other opsins are uncertain.
The crystal structure of bovine rhodopsin has been solved [44-46] (Figure (Figure2c).2c). K296 (in the single-letter amino-acid code) in helix VII binds retinal via a Schiff-base linkage, in which the nitrogen atom of the K296 amino group forms a double bond with the carbon atom at one end of the retinal (Figure (Figure2d).2d). The key residue K296 is important for light absorption and its presence or absence can be used to judge whether or not a newly found rhodopsin-type GPCR is really an opsin. The counterion is another important residue: it is a negatively charged amino acid that helps to stabilize the protonated Schiff base (see below). In the vertebrate visual and non-visual opsin subfamily, the highly conserved residue E113 serves as the counterion [47-49], whereas in other opsins position 113 is occupied by other amino acids (tyrosine, phenylalanine, methionine, or histidine) and the highly conserved E181 serves as the counterion. This difference suggests that counterion replacement has occurred during the molecular evolution of vertebrate visual and non-visual opsins [50,51].
Two photoreceptor cells are involved in vision in most vertebrates - rod and cone cells - and they are distinguishable by their shapes. The rod and cone cells contain different opsins: rods have rhodopsin, which underlies twilight vision, and cones have cone opsins, which underlie daylight (color) vision [1]. When excited by light in rod and cone cells, rhodopsin and cone pigments drive an enzyme cascade involving G proteins and their effectors: the excited pigments activate the G-protein transducin, which stimulates cGMP phosphodiesterase, resulting in a decrease in intracellular cGMP concentration. This decrease leads to closure of a cGMP-gated cation channel, leading to the hyperpolarization of the visual photoreceptor cell. In general, rods and cones contain distinct sets of phototransduction molecules (transducin, phosphodiesterases and channels) [52]. It should be noted that the visual opsins are also expressed in non-visual photoreceptor cells, including the pineal photoreceptor cells that are found in most non-mammalian vertebrates.
The lower-vertebrate non-visual opsin genes are expressed in photoreceptor cells other than rods and cones. For example, pinopsin is involved in photoreception in the pineal organs of birds [17,18] and lizards [19]. It is suggested to activate both transducin and the G-protein G11 and therefore to drive two different phototransduction cascades [53,54]. The parapinopsin recently found in the pineal organ of the lamprey [21] is a UV-sensitive and bistable opsin with stable dark and light-activated states. VA-opsin is found in the salmon retina [22] but in amacrine and horizontal cells (two kinds of neural cell in the retina), not in rod and cone visual cells [55]. A splice valiant of VA-opsin called VAL-opsin is localized to deep parts of the brain and the horizontal cells of the zebrafish [56].
The visual opsins of arthropods and molluscs belong to the Gq-coupled opsin group, which is different from the vertebrate visual opsin group. They are localized to the microvilli of the rhabdomeric photoreceptor cells, which are typical visual cells of arthropods and molluscs and are morphologically different from vertebrate rods and cones. These opsins are coupled to the signal-transduction cascades involving the G protein Gq and phosopholipase C [2,57-60] and leading to depolarization of the cells in response to light. The different subgroups of insect opsins have distinct absorption spectra; this underlies insect color vision. Vertebrate melanopsins are very similar to the Gq-coupled invertebrate opsins [29,30]; mouse melanopsin has been reported from knockout studies to be involved in the response of the pupil to light [61] and in the entrainment of circadian rhythm by light [62]. As suggested by their close relationship to the Gq-coupled opsins, melanopsin can be coupled to a Gq/phosopholipase-C cascade, similar to that used by the invertebrate opsins [63-65].
Mouse encephalopsin (also called panopsin) is strongly expressed in the brain and testes and weakly in other tissues [25], and the teleost homologs are localized to multiple tissues (they are therefore named teleost multiple tissue (tmt) opsins) [26]. The functions of the encephalopsins and tmt-opsins are unknown, but their close but distinct position in the phylogenetic tree relative to the vertebrate visual and non-visual opsins may mean that they are more llikely to have distinct functions.
Some invertebrates have photoreceptor cells - distinct from the rhabdomeric photoreceptors - that are called ciliary photoreceptors because their photoreceptive portions originate from cilia. Interestingly, the scallop (a bivalve mollusc) has both kinds, and in the ciliary photoreceptor cells a novel opsin has been found that is different from the Gq-coupled one [10]. It colocalizes with a large amount of Go-type G protein and is thought to activate Go in vivo; it is therefore named Go-coupled rhodopsin (or Go-coupled opsin). Electrophysiological evidence suggests that scallop Go-coupled rhodopsin elevates the intracellular cGMP concentration through light-dependent activation of Go, which leads to hyperpolarization of the cell [66].
Neuropsins are localized to the eye, brain, testes and spinal cord, but their functions are unknown. Peropsin was first found in the RPE of the mammalian eye [33]. It binds all-trans-retinal as a chromophore, and light isomerizes it to the 11-cis form [31] (Figure (Figure2b).2b). This photochemical property indicates that peropsin may serve as a retinal photoisomerase, like retinochromes and RGRs [34,35]. Retinochrome and RGR, the members of the retinal-photoisomerase subfamily, bind all-trans retinal (Figure (Figure2b)2b) as a chromophore [67,68] and are not coupled to G proteins, unlike the visual opsins, which bind the 11-cis form of retinal. Retinochrome and RGR have been identified in the mollusc and vertebrate retinas, specifically in the inner segments of the visual cells [69,70] and in the retinal pigment epithelium (RPE) [34], respectively. Irradiation of these two pigments causes the isomerization of all-trans retinal to the 11-cis form [67,68], suggesting that these opsins enzymatically generate the chromophore and supply it to the visual opsins [70,71].
The function of most opsins except for the photoisomerases can be divided into two parts: light absorption and G-protein activation. Most opsins function through absorption of visible light, but the chromophore retinal itself has an absorption maximum in the UV region, not in the visible region. This potential problem is solved by the opsins as follows. As previously described, retinal binds to K296 in helix VII through the protonated Schiff base (Figure (Figure2d);2d); the protonation, which results in the delocalization of π electrons within the retinal molecule, shifts its absorption spectrum towards visible light. In the protein, the proton on the Schiff base is unstable and a counterion, a negatively charged amino-acid residue, therefore needs to be present in order to stabilize it.
Absorption of light (a photon) by retinal results in its photoisomerization from the 11-cis to the all-trans form (Figure (Figure2b).2b). This is followed by a conformational change of the protein moiety, eventually resulting in activation of the G protein. Photochemical studies have identified some spectroscopically distinguished intermediates that form during bleaching of the vertebrate rhodopsin - 'batho', 'lumi', 'meta I', and 'meta II' - which appear on the picosecond, nanosecond, microsecond and millisecond timescales after light absorption, respectively [1]. Many biochemical and biophysical studies have focused on the question of what conformational changes take place in the protein moiety during the formation of the active state of opsins, especially the meta II intermediate of bovine rhodopsin. The most notable hypothesis is that light triggers the relative outward movement of helices III and VI [72,73] to form meta II, most likely following flipping-over of the retinal ring [74]. This movement of the helices could expose G-protein-binding sites, such as the cytoplasmic loop between helices V and VI [75,76]. This loop varies in sequence among the different subfamilies and underlies their selective coupling to different subtypes of G protein [77,78]. It is believed that a similar helix motion occurs in most members of the rhodopsin superfamily.
There are many unanswered questions concerning the functions of the different opsins. Recently, genetic approaches using knockout and/or transgenic animals have been used to understand the function and/or the expression mechanism of some opsins. Recent progress with RGR knockout mice concluded that RGR serves as the photoisomerase of retinal in vivo [71], and the function of melanopsin in the circadian clock has been studied with mutant mice lacking photoreception through rods and cones [62]. One interesting approach for investigating why there are so many kinds of opsins is functional replacement of one opsin with another and observing the altered phenotype. The first example of this approach was the experimental replacement of rhodopsin with cone opsin in transgenic Xenopus, by selective stimulation of the cone opsin in a single rod cell that contained both cone opsins and rhodopsins [79]. The 'knock-in' technique could be most useful for this kind of opsin-replacement experiment (H. Imai and Y. Shichida, unpublished observations).
GPCRs are important targets for drug discovery, and the opsin family is currently a good subject for such studies because it is the only family for which the structure of a member has been solved at high resolution. Structural studies of opsins could provide valuable information for understanding how GPCRs in general activate G proteins. Okada et al. [45] have investigated the photochemistry of the rhodopsin crystal, which raises the possibility of solving the structure of an active form of rhodopsin (meta II) at high resolution (2.5 Å). The crystal structure of the meta I photointermediate of rhodopsin has recently been solved to around 5.5 Å resolution [80]. The crystallization of a complex of active rhodopsin (meta II) with a G protein could be one of the breakthroughs that help to elucidate the G-protein-activating mechanism.
The author thanks Yoshinori Shichida of Kyoto University for valuable comments on this manuscript, Mitsumasa Koyanagi of Osaka University for useful discussions and help in preparation of Figure Figure1,1, and Hisao Tsukamoto for help in preparing the manuscript. This work was supported by Grants-in-Aid for Scientific Research from the Japanese Ministry of Education, Science, Sports, and Culture and the Grant for the Biodiversity Research of the 21st Century COE (A14).
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's Canada Institute for Scientific and Technical Information in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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| Tiger Rant
| Trying to figure out which away game to go to this year - cfish140 on 5/4/15 at 4:03 pm
I'm a rookie when it comes to sec away games. I've only been to bowl games and neutral sites and am looking to pop my cherry this year. Ideal spots are Tuscaloosa, Oxford, Columbia, or Starkville Tuscaloosa-buddy I'm going with has already been here plus I hate bama with a passion and don't k...
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| Saints Talk
| So win and we're in? - cfish140 on 12/15/14 at 10:39 pm
just beat atl? Or does carolina have to drop one also? TIA :cheers:...
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| Fantasy Sports Board
| Jonas gray, sankey, or sanu in the flex? - cfish140 on 11/30/14 at 7:28 am
Standard Gray @GB Sankey @HOUSTON Sanu @ TB TIA :cheers: ...
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| Movie/TV Board
| Anybody read The Malazan Book of the Fallen series? - cfish140 on 11/29/14 at 7:44 am
Looking for another fantasy series to get into while I wait on winds of winter. Anybody have a review on this series? The ones online mostly say it's a true epic but the characterization isn't great and it can be really confusing TIA...
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| O-T Lounge
| Obama officials report sandy hook not real?? - cfish140 on 6/24/14 at 5:15 pm
Could it really be true?? What say you? [link=(http://www.secretsofthefed.com/obama-officials-confirm-sandy-hook-drill-children-died/)]LINK[/link]...View Topic - Replies (13)
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| What's everyone doing for cinco de mayo? - cfish140 on 5/4/14 at 5:57 pm
I usually do serranos but that's out. I went to superior once and didn't think it was that fun...I was pretty young at the time though. I'm thinking la Carreta this year, I've never been and it seems like a good time. Anywhere else? Zippys maybe?...View Topic - Replies (24)
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| Rum House (br) grand opening tonight - cfish140 on 4/1/14 at 3:16 pm
Anybody going? Think im going to check it out. Never been to the one in Nola how is it?...
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| Music Board
| has anyone here been to Tomorrowland? - cfish140 on 11/5/13 at 3:05 pm
seriously considering going next year. for anyone thats been id like to here about your experience. How hard was it to get a ticket? i heard they sold out in 3 seconds last year. about how much money did it cost including plane ticket and concert ticket? did you stay in dreamville? i see its 2 hours...View Topic - Replies (5)
| SEC Rant
| Sooo it's Florida week (long)... - cfish140 on 10/6/13 at 9:44 am
There is a lot of discussion as to who lsu fans hate the most and who is their biggest rival. Many hate bama the most but for most there is a mutual respect, old timers will say ole miss but that rivalry has faded,tamu is climbing the ladder, some say auburn or maybe even Arkansas but as for me.... ...
Posted on SEC RantView Topic - Replies (13)
| Fantasy Sports Board
| Am I way over thinking this? - cfish140 on 9/8/13 at 10:59 am
So my 2 rbs are Arian foster and Stevan Ridley with Lamar miller in my flex and Isaac redman on my bench. Analysis says foster will be splitting carries with Ben Tate and he is not 100%. Analysis for redman says he will be recieving a heavy workload because he is pretty much Pitts only rb with leveo...
Posted on Fantasy Sports BoardView Topic - Replies (5)
| More Sports
| what are your go-to podcasts on the ESPN radio app? - cfish140 on 9/4/13 at 6:36 pm
just downloaded the app and of course i have the svp and rusillo show but was wondering what other good ones are out there? Finebaum? Cowherd? any good fantasy football podcasts? just no mike and mike... TIA oh and for reference im all about football and dont do MLB...
Posted on More SportsView Topic - Replies (5)
| SEC Rant
| Regardless of who won... - cfish140 on 8/30/13 at 12:10 am
He'll of a game both sides. Way to start off the season! :bow:...
Posted on SEC RantView Topic - Replies (5)
| Tiger Rant
| Can somebody please link me to the 9-6 reaction vid - cfish140 on 4/8/13 at 11:52 pm
Tia :geauxtigers:...
Posted on Tiger RantView Topic - Replies (1)
| More Sports
| Help settle me and my buddy's argument - cfish140 on 4/8/13 at 10:43 pm
Jon bones jones vs money mayweather in the octagon NO TAKEDOWNS ALLOWED who wins? I say he's a frickin idiot and mayweather would knock him out in 30 seconds he says mayweather couldnt handle the knees and kicks What say you?...
Posted on More SportsView Topic - Replies (13)
| Gaming Board
| Final Fantasy/lost odyssey - cfish140 on 3/18/13 at 5:13 pm
So i've had a lot of down time lately and was looking to start up a final fantasy game that i have yet to beat, or lost odyssey. I own 7-13 and the only ones i have not completed are 9, 12, and 13 as well as lost odyssey. I think im over 9, i have tried to start it back up at least 4-5 times and jus...
Posted on Gaming BoardView Topic - Replies (10)
| Music Board
| JUICY J to the Varsity April 30 - cfish140 on 3/6/13 at 4:53 pm
:nana: [link=(http://www.facebook.com/events/564116766941892/)]LINK[/link]...View Topic - Replies (4)
| Music Board
| Not a Drake fan but can't stop listening to his new track.. - cfish140 on 2/19/13 at 11:34 pm
[link=(http://www.youtube.com/watch?v=RubBzkZzpUA)]Started From the Bottom[/link] pretty catchy, definately one of those songs that gets stuck in your head...View Topic - Replies (3)
| Saints Talk
| Does anyone have a link to the full NFC championship game against the Vikings? - cfish140 on 9/4/12 at 8:13 pm
would like to watch it again TIA :whodat: ...
Posted on Saints TalkView Topic - Replies (4)
| Movie/TV Board
| thoughts on Nip Tuck? - cfish140 on 8/11/12 at 9:14 pm
Was helping somebody move out the other day and noticed they had all the Nip Tuck seasons on DVD and said she would let me borrow them. I've been watching Friday Night Lights and am halfway through the first season and it's just meh. I remember in high school everybody was obsessed with NT. I he...
Posted on Movie/TV BoardView Topic - Replies (12)
| O-T Lounge
| Rumor about the cottages - cfish140 on 7/30/12 at 5:46 pm
Word around town is that they had a big orgy in the sauna the other day...anybody else hear this?...View Topic - Replies (12)
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"Every citizen in our country deserves our best effort. With the help of the health information derived from these studies, we can take a step closer to achieving our goals and, at the same time, transform our communities into safer and healthier places for all people," said Garth Graham, MD, deputy assistant secretary for minority health and OMH director.
The awards are part of the investments made under the American Recovery and Reinvestment Act of 2009 (ARRA), which appropriated $1.1 billion to support patient-centered outcomes research. Of that total, $400 million was authorized to be allocated at the discretion of the HHS secretary for various patient-centered outcomes research and related activities.
The American College of Physicians, (ACP) in an updated paper released in July, noted that as the nation's population continues to grow and diversify, the healthcare system needs to change and adjust to meet the needs of an increasingly multicultural patient base.
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Dates and cities have been announced for the 2014 BancorpSouth Rebel Road Trip, Ole Miss' third annual tour of the state and surrounding areas.
Click here for the original story.
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well im 21 im a male, im single and looking. i like to meet new people. im not your average guy and i can guarentee you havnt met anyone like me. im athletic and i like most sports, i work in the construction buisness mostly doing demolition. i have my own place, my own car, and like i just said i can hold a good paying job. im very patient and mellow and i dont like to fight. call me cheap but i dont care i like to stay home i worked hard for what i have so its nice just sitting on my couch, that being said i like to show off my woman so i do like going out sometimes.
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24 • Harrisburg, PA • Man
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My details
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Write a little about yourself. Just a paragraph will do.
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Don't overthink this one; tell us what you're doing day-to-day.
im just living life right now, hanging out with friends, drinking, working, and enjoying the little things.
I'm really good at
Go on, brag a little (or a lot). We won't judge.
im patient. im a good listener. i give good advice and im pretty wise for my age. im good with my hands and im mechanically inclined with most things.
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idk...my appearance.
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i dont read too many books nowadays, favorite movies are BASEketball, hangover, stepbrothers most comedy movies, same with tv shows i like the office, family guy, big bang theory, mostly comedies i also like intense shows like s.o.a, heros, law and order. im pretty open to most music i just like a good rythem to listen too. and food...just about anything im not picky about what i eat at all food is definitly the way to my heart haha.
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my car
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I spend a lot of time thinking about
Global warming, lunch, or your next vacation… it's all fair game.
when the right person will come along that can make me happy.
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i secretly....just wanna be happy with a beautiful woman.
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you should message me if your a single attractive young adult who has a plan in life, doesnt dwell on the past, is happy with themself and can make me happier then i am. someone who isnt petty and someone who is drama free. you should be mellow and love to laugh.
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OK, college kids, we know that you immediately will believe anything that a dumb Internet message tells you, but this e-mail from George Mason University's "Provost" is, in fact, a hoax sent by racist hackers trying to stop the black guy from winning Virginia. So go out and vote as planned, it won't take long, and then you can continue to play your Britney Spears Xbox games on the Wii.
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I am trying to send messages from seagull to freeradius. I am using seagull with radius protocol.
Every time I am sending a message from seagull to freeradius ,it is decode the password differently.
I am also getting the following error in Radius debug mode .
Login incorrect: [username/password] (from client test1 port 0)
WARNING: Unprintable characters in the password. Double-check the shared secret on the server and the NAS!
Can anyone please tell me how to set shared secret in seagull?? Please help.
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Hi everyone,
Diameter scenario of voice monitored call.
Is there any condition-clause in traffic section so that I could divide my scenario into two branches, first will be default scenario, second will be CCR-T sending and release of diameter session?
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Justin Bieber wants to work with Cheryl Cole - Alexandra Burke talks tour - Morning Parade's influences.
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My only thing with "constraining" the media, is that it could encroach on freedom of speech. Slippery slope and all that.
This is a discussion on What Mass Killers WantAnd How to Stop Them: WSJ within the The Second Amendment & Gun Legislation Discussion forums, part of the Related Topics category; I put this newslink in the 2A Section inasmuch as mass murders create some of the greatest risks of our 2A rights How to Stop ...
I put this newslink in the 2A Section inasmuch as mass murders create some of the greatest risks of our 2A rights
How to Stop Mass Shootings - WSJ.com
This is an interesting analysis focused more on the individuals, motives, reasons and patterns behind mass murderers, rather than the weapons. This is, I believe, is the only comment about guns in the entire article:
One of the observations notes:Massacres also would not be nearly so lethal without the widespread availability of guns and high-capacity magazines designed more for offense than for defense.
A 2003 study led by Columbia University psychiatrist Madelyn Gould found "ample evidence" of a suicide contagion effect, fed by reports in the media. A 2011 study in the journal BMC Public Health found, unsurprisingly, that this effect is especially strong for novel forms of suicide that receive outsize attention in the press.At the end are several common sense ideas which have appeal, but don't sell airtime or magazines. Neither do the ideas pander to the charlatans that need another tragedy to push for more gun control.Some researchers have even put the theory to the test. In 1984, a rash of suicides broke out on the subway system in Vienna. As the death toll climbed, a group of researchers at the Austrian Association for Suicide Prevention theorized that sensational reporting was inadvertently glorifying the suicides. Three years into the epidemic, the researchers persuaded local media to change their coverage by minimizing details and photos, avoiding romantic language and simplistic explanations of motives, moving the stories from the front page and keeping the word "suicide" out of the headlines. Subway suicides promptly dropped by 75%.
The author does not suggest "more guns" (as most of us would suggest, and as in fact the NRA suggested), but more constrained media.
Personally, I would like to see more analysis, and considerable thought expended locally and nationally on this type of approach.
Thoughts? More ideas? Is this worth sharing in local medias?
(Please avoid discussing topics such as political charlatans we know and love, gun control bashing, and other taboo topics. I'd like this open for discussions and ideas!)
Last edited by Rock and Glock; November 9th, 2013 at 05:39 PM.
ΜΟΛΩΝ ΛΑΒΕ: Buy These Stickers Here
"He went on two legs, wore clothes and was a human being, but nevertheless he was in reality a wolf of the Steppes. He had learned a good deal . . . and was a fairly clever fellow. What he had not learned, however, was this: to find contentment in himself and his own life. The cause of this apparently was that at the bottom of his heart he knew all the time (or thought he knew) that he was in reality not a man, but a wolf of the Steppes."
My only thing with "constraining" the media, is that it could encroach on freedom of speech. Slippery slope and all that.
weekend pre-apocolypse nomadic warrior, leather duster and all.
weekend pre-apocolypse nomadic warrior, leather duster and all.
R & G I am not sure I have a good enough understanding of the human brain to figure out whether the news report is right or wrong in their assumptions. I get what they are saying, but will it really work? We have so many ways of getting news now a days that I really do not believe that these kind of events can be controlled. In theory is sounds good, but other countries do not have the freedoms we do.
Don"t let stupid be your skill set....
Hobbit lives matter....
Never be ashamed of a scar. It simply means, that you were stronger than whatever tried to hurt you......
Although we can not alter the behavior of "the press" legislatively, we can register public disgust in the hope that they will self-moderate and self-censor.
I think the WSJ is to be commended for this article.
If the Union is once severed, the line of separation will grow wider and wider, and the controversies which are now debated and settled in the halls of legislation will then be tried in fields of battle and determined by the sword.
Andrew Jackson
For every sensationalized murder or killing spree Law Enforcement always expects at least one copycat or attempted copycat.
Liberty Over Tyranny Μολὼν λαβέ
Interesting reading. I had suspected that the amount of media coverage have much to do with it. As so many of them seem to be copycats.
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Report the news, but make it a crime to report the name or show a likeness of the perp.
KNOWLEDGE: A tomato is a fruit.
WISDOM: Not putting a tomato in a fruit salad..
You two need to understand who controls the "content" of what news THEY want to give;
See below
FRANKLIN D. ROOSEVELT, U.S. President, in a letter written November 21, 1933 to Colonel E. Mandell House, Roosevelt states: "The real truth of the matter is, as you and I know, that a financial element in the large centers has owned the government of the U.S. since the days of Andrew Jackson." (History points to the last truly honorable and incorruptible American president as Andrew Jackson "Old Hickory".)
PETER HOAGLAND, Nebraska State Senator and Humanist, speaking on radio in 1983 with the great American Pastor and Patriot Everett Sileven said: "Fundamental, Bible believing people do not have the right to indoctrinate their children in their religious beliefs because we, the state, are preparing them for the year 2000, when America will be part of a one-world global society and their children will not fit in."
DAVID ROCKEFELLER, Internationalist billionaire, Humanist, CFR kingpin, founder of the Trilateralist Commission, World Order Godfather (and in all probability the High School graduate voted "Most Likely to Be Hanged for Treason"), voiced his praise of the controlled U.S. media for keeping their oath not to divulge the Globalist plans to the public. Speaking to his fellow conspirators at a meeting, June 1991 in Baden Baden, Germany, of yet one more infamous World Order group, the Bilderbergers, Mr. Rockefeller said:
"We are grateful to the Washington Post, The New York Times, Time Magazine and other great publications whose directors have attended our meetings and respected their promises of discretion for almost forty years."
"It would have been impossible for us to develop our plan for the world if we had been subjected to the lights of publicity during those years. But, the world is now more sophisticated and prepared to march towards a world government. The supranational sovereignty of an intellectual elite and world bankers is surely preferable to the national auto-determination practiced in past centuries."
(It is not reported if the attendees kissed his ring - or anything else - after their leader bestowed his blessing on those in attendance). Actually, we could ask Governor Clinton or Dan Quayle, both of whom were there. Bush and Clinton are Bilderbergers, Internationalists, and their goals are exactly the same for America.
Let us repeat ...CLINTON'S, BUSH'S, AND PEROT'S, PLANS FOR AMERICA ARE VIRTUALLY IDENTICAL. The Republicans and Democrats goals for America are virtually identical. They both are taking our nation into global government.
JAMES PAUL WARBURG, Foreign Agent of the Rothschild Dynasty, major player in the Federal Reserve Act scam: on February 17, 1950, while speaking before the United States Senate, this pompous Internationalist boasted confidently, "We shall have World Government, whether or not we like it. The only question is whether World Government will be achieved by conquest or consent."
ROBERT KENNEDY, former U.S. Attorney General of the U.S.: "All of us will ultimately be judged on the effort we have contributed to building a NEW WORLD ORDER." - 1967 (We can all agree with Robert on one thing: All traitors who participate in the N.W.O. WILL be judged one day!)
GEORGE W. MALLONE, U.S. Senator (Nevada), speaking before Congress in 1957, alluded to the families that secretly own the "Federal" Reserve Bank and control the finances of the U.S. He stated:
"I believe that if the people of this nation fully understood what Congress has done to them over the last 49 years, they would move on Washington; they would not wait for an election... It adds up to a preconceived plan to destroy the economic and social independence of the United States!"
As in all investigations, it always comes down to, "How can we prove our case?" We personally feel it's hard to top the proof coming from the mouths of the very ones involved in this treacherous unAmerican program. Here's one terrific example. John Swinton, the former Chief of Staff for the New York Times, was one of America's best loved newspapermen. Called by his peers "The Dean of his Profession", John was asked in 1953 to give a toast before the New York Press Club, and in so doing made a monumentally important and revealing statement. He is quoted as follows:
"There is no such thing, at this date of the world's history, in America as an independent press. You know it and I know it. There is not one of you who dares to write your honest opinions, and if you did, you know beforehand that it would never appear in print. I am paid weekly for keeping my honest opinions out of the paper I am connected with. Others of you are paid similar salaries for similar things, and any of you who would be so foolish as to write honest opinions would be out on the streets looking for another job. If I allowed my honest opinions to appear in one issue of my paper, before twenty-four hours my occupation would be gone. The business of the journalists is to destroy the truth; to lie outright; to pervert; to vilify; to fawn at the feet of mammon, and to sell his country and his race for his daily bread. You know it and I know it and what folly is this toasting an independent press? We are the tools and vassals of rich men behind the scenes. We are jumping jacks, they pull the strings and we dance. Our talents, our possibilities and our lives are all the property of other men. We are intellectual prostitutes."
from here; Operation Vampire Killer 2000 - The Lawful Path
People, this stuff is out there for you to read and investigate
I would rather die with good men than hide with cowards
If you want to make God laugh, tell him your plans.
"Politics is the art of looking for trouble, finding it whether it exists or not, diagnosing it incorrectly, and applying the wrong remedy."
M&Pc .357sig, 2340Sigpro .357sig
Everyone wants that 15 minutes of fame, even crazy people.
Retired USAF E-8. Lighten up and enjoy life because:
Paranoia strikes deep, into your life it will creep. It starts when you're always afraid... Buffalo Springfield - For What It's Worth
Yes, I agree that gratuitous spotlighting of 'ragers and their activities should be glossed over. Just the facts, ma'am. Just the facts.Originally Posted by From the WSJ article
But I also agree that the most reliable way to stop them in the act is as was done with The Dalton Gang as they were gunned down exiting the bank in Coffeyville, KS, back when. THAT is how you stop the most violent felons ... you stop them permanently, expeditiously and with extreme prejudice, on-site on the instant they're caught doing whatever. And the only way to get there is for all upstanding people to have the ability to withstand such violence perpetrated against them. Get there, and we'll have a fighting chance. Fail to do that, and we'll continue muddling along while wringing our hands over what to do that could be considered effective.
Your best weapon is your brain. Don't leave home without it.
Thoughts: Justifiable self defense (A.O.J.).
Explain: How does disarming victims reduce the number of victims?
Reason over Force: Why the Gun is Civilization (Marko Kloos).
In relation to the media's role, I would like to see them be more responsible and less biased. I'm not holding my breath because it seems like most have little or no shame. Every incident seems to result in several reports that are later proved inaccurate and plain wrong. Also, all the focus does give some the spotlight they may crave thus encouraging copycats, but overall, we've been pretty lucky that most do not as most are not suicidal even if they deeply crave some attention.
As for the why, this is the much more difficult job. Most shooters end up killing themselves so they're not around to ask why and get an explanation, once the legal trials are done. I think of it as a room filling with gas (the fuel), just waiting for a spark (the catalyst). For example, we know the Oak Creek Sikh Temple shooter was a white supremist and that was part of the fuel building. Was it all the fuel? He was involved in the movement for years and didn't act prior. Other are part of similar movements, but we don't have regular incidents of white supremist's attacking. What was the catalyst that moved him to action? Same for Newtown, we know the 20 year old had some socialization issues, potentially some for of autism, but he had little or no history of violently acting out. We know he was fascinated by the Belgian mass murderer and wanted a higher body count, but what were his fuels that built up, and what was the catalyst that made him start his planning, then act. It is real hard work, which is why most of the media, politicians, and advocates don't want to do it and focus on a piece of metal and plastic. We do have the Aurora and Tucson shooters and it would be great to know what was going on that fueled them to act out and what was the critical event that set them in motion.
Kahr CW380, Kahr P9, Walther P99AS
I find it strange that people that so strongly support the 2nd Amendment, would have no problem with infringing on the 1st Amendment.


text:
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text:
Derry fly flag in clash with Lancashire ladies
Derry will carry the flag for Ulster in the All-Ireland Ladies' Junior Football Championship when they take on Lancashire at St Brendan's, Manchester, today (5pm).
Derry will carry the flag for Ulster in the All-Ireland Ladies' Junior Football Championship when they take on Lancashire at St Brendan's, Manchester, today (5pm).
Tyrone manager Mickey Harte has launched a scathing attack on what he terms "the nit-pickers" who he feels are doing football a grave disservice.
Kerry manager Eamonn Fitzmaurice has stated that he fully expects Tyrone's Tiernan McCann to have his proposed eight-week suspension overturned in time to play in the All-Ireland semi-final between the sides on Sunday week.
Derry and Ulster club football champions Slaughtneil have endured their share of trauma since losing out in the All-Ireland club final to Corofin back in March.
I can totally understand why the GAA have come out strongly and have proposed an eight-week ban on Tyrone's Tiernan McCann.
Mickey Harte remained tight-lipped last night when asked his thoughts on the proposed eight-week ban handed down to Tiernan McCann by the GAA's Central Competition Controls Committee.
GAA pundit Joe Brolly believes there is no way that the GAA can lawfully impose an eight-game ban on Tyrone's Tiernan McCann.
Tyrone player Tiernan McCann has been slapped with a two month ban by the Central Competition Control Committee of the GAA following his dive during last weekend's All-Ireland quarter-final win over Monaghan.
Donegal manager Rory Gallagher will not be counting on two-time All-Star goalkeeper Paul Durcan as he makes plans for the 2016 National League.
Tyrone boss Mickey Harte says he can understand why Tiernan McCann has been heavily criticised following his play-acting in Saturday's All-Ireland quarter-final.
Tyrone manager Mickey Harte has launched a spirited defence of under-fire Tiernan McCann but admitted that the player realises he would 'respond differently' if a similar incident happened again.
Tyrone's victory over Monaghan became very bitter and physical towards the end of the game but one incident in particular has attracted a lot of attention.
Former president of the GAA, Nickey Brennan, has confirmed a Garda investigation has taken place into an incident which saw a man secretly take a photograph of him in the men's changing room of a leisure facility in a Kilkenny hotel.
Donegal boss Rory Gallagher may have a battle on his hands to keep a number of his squad from opting for retirement after their heavy loss to Mayo in Saturday's All-Ireland quarter-final.
If Kilkenny hurling fans are beginning to take their hurling heroes for granted after securing a remarkable 14th All-Ireland final spot in the Brian Cody era, they should consider the remarkable deeds of Richie Hogan.
Not for the first time, the qualifier route has proved a productive avenue of redemption for Tyrone.
Victory can sometimes be accompanied by a bittersweet flavour. Tyrone will know what I mean, assuming they have an acquaintance with social media in particular.
Caroline O'Hanlon put on an All-Star performance on her birthday as Armagh had simply too much for Westmeath in Saturday's All-Ireland qualifier.
There is more than a touch of irony in the fact that the stage is set for a compelling All-Ireland semi-final at the end of a week which has yet again highlighted disenchantment, frustration and indeed anger in what is considered to be Ulster's premier hurling county.
Armagh manager James Daly is hoping the fact that his side have held the whip hand over Westmeath in recent years will stand them in good stead when they renew rivalry in the All-Ireland Ladies Football Championship at Kingspan Breffni Park, Cavan, tonight (7.15pm).
World Cup
Republic of Ireland
Republic of Ireland


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My Acting Bucket List: Colleen Kollar Smith
The new Executive Director of San Diego Musical Theatre directs, choreographs, acts, sings, and creates
Jeff Smith 6 p.m., Oct. 8
Posted May 6, 2013
A classic coastal town on the PCH.
Unexpected. That's the word that comes to mind when I think about my recent trip to Cambria, California. Cambria, located roughly a half hour north of San Louis Obispo, reminded me of the Midwest somehow. ...


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Spring Clasp Jewelry
- $12,300.00David Webb bracelet, from the Tool Chest Collection. 18-karat yellow gold with polished finish. Nail-shaped links. Approx. 7.5"L and 0.5"W wide. Spring clasp.
- $460.00Handwoven sterling silver. Spring clasp. 16"L. Handcrafted in Bali.
- $510.00Handwoven sterling silver. Spring clasp. 18"L.
- $720.00Handwoven sterling silver. Spring clasp. 18"L. Handcrafted in Bali.
- $2,495.00Sterling silver wire rings are meticulously crosswoven into this spiraling piece featuring a spring clasp faceted with pave diamonds. An exceptional combination of strength and flexibility enables this chain-woven bracelet to conform to the contours....
- $995.00Ippolita medium pendant necklace. 18-karat yellow gold. Round pendant with blue topaz over labradorite. Adjustable cable chain, 16-18"L. Spring clasp. Imported.
- $18,000.00Paul Morelli bangle bracelet, from the Confetti collection. 18-karat white gold. Round-cut white diamonds. 3.24 total diamond carat weight. Spring clasp with safety. Approx. 50mm/2" diameter.
- $395.00Ippolita necklace from the Lollipop� Collection. Signature hand-hammered sterling silver. Turquoise or clear quartz over mother-of-pearl pendant. Pave diamond bezel, 0.08 total carat weight. Adjustable cable chain, 16-18"L. Spring clasp. Im...


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New teas have arrived! All teas are listed at 20% off their regular price.
Products are not discounted. These special prices are only available by ordering through our website.
Pistachio Shortbread | Black Tea
This black tea blend is smooth, rich, sweet, and silky, with notes of pistachio coming through. Contains: black tea, pistachios, flavor, rose petals, Marzipan drops, almonds.
Seasonal only.
The scents and tastes of Xmas come through in this tea. Sweet, smooth, cranberryish, and a little spicy. Contains: black tea, orange peel, almond pieces, cranberry pieces, cardamom pods, flavor, strawberry pieces, raspberry pieces.
Seasonal only.
Warming, bracing, savory, cocoa-citrus notes in the finish, Contains: apple pieces, cocoa peel, moringa leaves, orange peel, flavor, raspberry leaves, whole cardamom, marigold blossoms.
Seasonal only.
Green Tea: A Quest for Fresh Leaf & Timeless Craft
Our friends at Camellia Sinensis in Montreal (Kevin Gascoyne & company) have written a fascinating book that helps contemporary tea drinkers understand the ancient and mystical craft of green tea.
Filled with illustrations. Edited by Bruce Richardson.
Special teas should be in a special canister. This attractive canister has an inner lid for keeping teas extra fresh. Holds approximately four ounces of small leaf teas.
Cats, what more needs to be said. Holds 2 ounces of most teas.


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LUDLOW FALLS — Paul H. Reinhardt, 89, of Ludlow Falls, passed away Monday, Sept. 1, 2014, at Genesis Healthcare-Troy Center.
A funeral service will be conducted at 11 a.m. Saturday, September 6, at Hale-Sarver Family Funeral Home, 284 N. Miami St., West Milton. Burial will be in Old Union Cemetery, Ludlow Falls, at a later date. Visitation will be from 6-8 p.m. Friday, and 10-11 a.m. Saturday, at the funeral home. Memorial contributions may be made to Ludlow Falls Christian Church, P.O. Box 115, Ludlow Falls, OH 45339. Online memories may be left for the family at the www.hale-sarver.com.
The My Memorials Facebook app allows you to:


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1 - 5 out of 5 results for Protective Gear (About)
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AFRICA/SUDAN - The continuous bombing on villages in the Nuba Mountains aims to drive out the civilians
Khartoum (Agenzia Fides) - The Air Force of Khartoum continues to bomb villages of the Nuba Mountains in South Kordofan, State of Sudan on the border with South Sudan, where a strong military confrontation has long been opposing the Sudanese army to the fighters of the SPLM -N (Sudan People's Liberation Movement-North).
According to a spokesperson of the SPLM-N, quoted by Sudan Radio Network, between March 31 and April 1, the Sudanese planes launched 17 bombs on several villages in the area. According to the report entitled "New War, Old Enemies: Conflict Dynamics in South Kordofan" of the organization Small Arms Survey, aerial bombingt do not bring significant advantages at a military level to the troops of Khartoum in the ongoing fighting, but aim to terrorize civilians, forcing them to flee. (L.M.) (Agenzia Fides 05/04/2013)
Receive News from Fides Service in your email
- 2015-09-16 - No school for children living in IDP camps in Darfur
- 2015-08-05 - Rain and wind storms are causing severe damage in South Darfur
- 2015-07-07 - The Church organizes schools for South Sudanese refugees in Khartoum
- 2015-06-15 - "Assurance in South Africa: President Bashir will leave", said a spokesman in Khartoum
- 2015-04-28 - Omar Hassan al-Bashir re-elected President with 94% of the votes
- 2015-04-22 - Outbreak of measles in Darfur: cases continue to multiply
- 2015-04-15 - 70 thousand bags of Carcinogenic Sugar distributed in South Darfur
- 2015-04-13 - AFRICA/SUDAN – Elections contested by the opposition begin, while tension increases with South Sudan
- 2015-02-25 - The number of homeless children, 700 000 live on the streets of the capital
- 2015-02-12 - Hunger and diseases for the displaced persons in Darfur: food, medicines and basic necessities are needed


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None of this will prevent a renewed and likely very contentious debate over funding in the late summer and fall. But if we can find a way to give the surge a chance, yet evaluate it according to demanding and realistic criteria after a few months, we will be doing better as a nation than now.
Michael O'Hanlon is senior fellow at the Brookings Institution.


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Is this restaurant good for breakfast?
Is this restaurant good for dinner?
Is this restaurant good for lunch?
Does this restaurant serve roast beef?
Is this restaurant good for brunch?
Is this restaurant family-friendly?
Does this restaurant offer takeout or food to go?
Does this restaurant offer free wifi?
Does this restaurant offer delivery?
Is this restaurant wheelchair accessable?
Thanks for helping!
Swiston's had been in Tonawanda for years and always sold only roast beef on kimmelweck. Their sandwiches used to be really full of beef, but now they've become skimpy. It is time to expand their menu.
Last minute stop at Swiston's today. Quiet but steady place, plenty of free parking, Great view of the creek, lots of boaters stopping in for a quick bite and a drink. Popcorn is a salty as you wanted to be. The beers are serving frozen glasses. Great local craft beer. And of course birch beer for the kids. They only...
I went to Swistons for many years for their Beef on awe I and their Homemade Chili, but it has been several years since I have been there because I moved from the area. I could not believe how much the food has changed, and NOT for the better. It changed so much I am wondering if the people that...
very,very,very limited menu, i would rather eat at a roadside stand. Go to arby's, they have a better menu
Did I spell that correctly? Beef on wec? Weck? Regardless, this was probably the best roast beef sandwich I have ever had in my life. Delicious!
Stopped for late lunch. Had been several yrs since last visit. They "used to have" good beef sandwich. Very dark inside-for good reason. Your choice is only between beef sandwich or chili. Companion ordered beef. I ordered chili. While waiting at counter for our order, the boss came out and put those large dishwasher trays full of clean dishes right...
My wife and two others went to Swiston's because we heard that they served a good roast beef
sandwich. In Buffalo, New York, where we live, roast beef on a kummelwick ( salted ) roll is as
famous as Buffalo chicken wings. We ordered the roast beef sandwich and found out the only
side dish that was served was a...
Been awhile, but worth the wait. Great roast beef sandwich. If you're looking for fine dining this is not your place. If you're looking for good food, friendly staff, and casual atmosphere than you'll like it here.
Went for late mothers day dinner approx 7 pm when we walked in a staff person in a very rushed voice said go in the back , sit down , i will be there. We walked to the dining area , no one thete, many tables clutterd with dirty dishes and food. Decided to read trip advisor reviews and pretty...
Visiting Buffalo after many years away. Beef on wick is high on the list of must have's Swiston's was not as I remembered it. Sandwiches were dry, no au jus on the side, They were thick with meat, but small. We got charged for drinks we did not order. When brought to the waitress's attention, she handed us our correct...
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No. 38 – Acknowledgement of Service – England & Wales
As discussed in Part 8 of Divorce 101, the divorce procedure in England & Wales has three main stages: service of the divorce petition; decree nisi; and decree absolute.
In this blog, we continue our analysis of the first stage: service of the divorce petition.
Service of petition
After the court receives the divorce petition, it will send a copy to the respondent (and any co-respondent).
Alongside the petition, the court will send the respondent a statement of arrangements (if the couple have children) – this is served only on the respondent, even if there is a co-respondent who will be served with the other documents.
The court will also send a 'notice of proceedings' and 'acknowledgement of service' form D10.
Notice of issue of petition
The court will then send the petitioner form D9H 'notice of issue of petition,' which states when the petition was sent to the respondent, acts as a receipt for payment of court fees (if applicable), and provides a divorce case reference number.
It also tells the petitioner what to do if the respondent (or any co-respondent) fails to reply to the petition.
Acknowledgement of service
(i) Respondent's options
The respondent (and any co-respondent) have eight days to return form D10.
The eight days start on the day after they receive the petition. (NB. If the
respondent and/or co-respondent live outside England & Wales, the court may
grant more time to respond.)
On receiving the petition and other documents, the respondent may decide to:
- refuse to acknowledge service;
- acknowledge service but contest the petition &/or the court's
jurisdiction; or
- acknowledge service & agree with the petition.
(ii) Failure to acknowledge service
If the respondent (or any co-respondent) fail to acknowledge service, the
court should send the petitioner two copies of form D89 'request for bailiff
The petitioner should then fill in the forms and return them to the court,
alongside a photograph or written description of the respondent (and any
co-respondent) plus a fee for each person being served – court staff can provide
information on how much the fee is.
After the forms are received, the court bailiff will attempt to deliver the
petition and other documents to the respondent (&/or co-respondent)
If the bailiff is still unable to effect service, the court may rule that
everything possible has been done, and proceed without actual service.
(iii) Service acknowledged
If the respondent returns form D10, the court will send the petitioner a copy
along with Leaflet D186 'The respondent has replied to my petition – what
must I do', which tells the petitioner what to do next.
The respondent will indicate on the form whether or not they intend to defend the
divorce and disagree with the financial arrangements, payment of costs, and the statement of arrangements for the children (NB. if they
disagree, they must set out alternative arrangements).
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Police identify baby boy found dead over weekendUPDATED 3:00 PM CDT Mar 10, 2014
Police identify the baby found dead over the weekend. Meantime, the baby's mother survived a suspected drug overdose and is facing possible charges. Nick Bohr will have the latest on WISN 12 News at 5:00.
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CommentsThe views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.blog comments powered by Disqus


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Talents View in Talent Calculator
- Desperate Prayer
- Phantasm
- Surge of Darkness
- Void Tendrils
- Twist of Fate
- Divine Star
- Void Entropy
Desperate Prayer
2 min cooldown Instant
Heals the caster for 34,808.
Activating Fade removes all movement impairing effects and prevents your movement speed from being reduced for 5 sec.
Surge of Darkness
Your Vampiric Touch and Devouring Plague damage has a 12% chance to cause your next Mind Spike not to consume your damage over time effects, be instant, and deal 50% additional damage. Can accumulate up to 3 charges.
Void Tendrils
1% of base mana
30 sec cooldown Instant
Summons shadowy tendrils, rooting up to 5 enemy targets within 8 yards for 20 sec or until the tendril is killed.
Twist of Fate
After healing a target below 35% health, you deal 15% increased damage and healing for 10 sec.
Divine Star
30 yd range 0.5% of base mana
15 sec cooldown Instant
Fire a Divine Star forward 24 yds, damaging enemies in its path for 2,171. After reaching its destination, the Divine Star returns to you, damaging enemies in its path again.
Void Entropy
40 yd range 3 Shadow Orbs
1.5 sec cast
Consumes 3 Shadow Orbs to deal 48,867 Shadow damage over 1 min.
Devouring Plague will refresh this effect to its full 1 min duration.
Devouring Plague will refresh this effect to its full 1 min duration.
Major Glyphs
Glyph of Dispersion
ShadowPassiveReduces the cooldown on Dispersion by 15 sec.
Glyph of Focused MendingPassiveCauses your Prayer of Mending to only bounce between the target and the caster.
Glyph of Mind Spike
ShadowPassiveYour successful non-instant Mind Spikes reduce the cast time of your next Mind Blast within 9 sec by 50%. This effect can stack up to 2 times.
Minor Glyphs
Glyph of Dark Archangel
ShadowPassiveWhen you apply Devouring Plague to a target, you take on the form of a Dark Archangel for 8 sec.
Glyph of Shadow Ravens
ShadowPassiveYour Shadow Orbs now appear as Shadow Ravens.
Glyph of Shadow
ShadowPassiveAlters the appearance of your Shadowform to be less transparent.
- Desperate Prayer
- Body and Soul
- Power Word: Solace
- Void Tendrils
- Power Infusion
- Cascade
- Clarity of Will
Desperate Prayer
2 min cooldown Instant
Heals the caster for 34,808.
Body and Soul
Your Power Word: Shield and Leap of Faith also increase your target's movement speed by 60% for 4 sec.
Power Word: Solace
30 yd range
10 sec cooldown Instant
Strike an enemy with heavenly power, dealing 6,322 Holy damage, an additional 693 Holy damage over 9 sec, and restoring 2% of maximum mana. This damage will heal a nearby injured ally for 100% of the damage dealt, or half as much if it heals the Priest.
Replaces Holy Fire.
Replaces Holy Fire.
Void Tendrils
1% of base mana
30 sec cooldown Instant
Summons shadowy tendrils, rooting up to 5 enemy targets within 8 yards for 20 sec or until the tendril is killed.
Power Infusion
2 min cooldown Instant
Infuses the Priest with power for 20 sec, increasing haste by 25% and reducing the mana cost of all spells by 20%.
40 yd range 2.4% of base mana
25 sec cooldown 1.5 sec cast
Launch a Holy bolt that grows in power with distance, healing an ally for up to 1,488, and then bouncing to additional allies 4 times. Each time it bounces, it splits into 2 bolts.
Clarity of Will
40 yd range 3.15% of base mana
2.5 sec cast
Shields the target with a protective ward, absorbing 22,738 damage within 20 sec.
Major Glyphs
Glyph of Penance
DisciplinePassiveIncreases the mana cost of Penance by 20% but allows Penance to be cast while moving.
Glyph of Holy Fire
Discipline, HolyPassiveIncreases the range of your Holy Fire, Smite, and Power Word: Solace spells by 10 yards.
Glyph of Power Word: ShieldPassive20% of the absorb from your Power Word: Shield spell is converted into healing.
Minor Glyphs
Glyph of the HeavensPassiveYour Levitate targets will appear to be riding on a cloud for the duration of the spell.
Glyph of AngelsPassiveYour heal spells momentarily grant you angelic wings.
Glyph of Borrowed Time
DisciplinePassiveYour Borrowed Time is now displayed visually.
- Health245580
- Mana160000
- Intellect 3459
- Spell Power 4914
- Haste 14.16%
- Crit 11.56%
- Mastery 35.51%
- Multistrike 11.68%
- Versatility 6.60%
- Intellect 3459
- Spell Power 4914
- Crit 11.56%
- Spirit 1187
- Haste 14.16%
- Mastery 35.51%
- Multistrike 11.68%
- Versatility 6.60%
- Strength 843
- Agility 1067
- Intellect 3459
- Stamina 4093
- Damage 237–443
- Attack Power 0
- Speed 1.58
- Spell Power 4914
- Mana Regen 8092
- Armour 675
- Dodge 3.00%
- Parry 0.00%
- Block 0.00%
- Crit 11.56%
- Haste 14.16%
- Mastery 35.51%
- Spirit 1187
- Bonus Armor 0
- Multistrike 11.68%
- Leech 0.00%
- Versatility 6.60%
- Avoidance 0.00%
Recent Activity
- Obtained Robes of the Arcane Ultimatum.
- 30/09/2015
- Earned the achievement Trapper's Delight for 5 points.
- 25/08/2015
- Earned the achievement Keeping It Rare for 5 points.
- 25/08/2015
- 1 Sha of Fear kills (Terrace of Endless Spring)
- 21/08/2015
Player vs. Player
- 2802 Honourable kills
Challenge Mode
Raid Progression
Last updated on 30/09/2015


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Book your room at Thou Walla Sunset Retreat
Grevillea CabinMax Occupancy: 2 guests
Waterview Standard CottageMax Occupancy: 2 guests
Waterview Spa VillaMax Occupancy: 2 guests
Waterview Sunset VillaMax Occupancy: 2 guests
Standard VillaMax Occupancy: 4 guests
Get an overview of this hotelAdults-only caravan park/campground in Soldiers Point with free parking
At Thou Walla Sunset Retreat, you'll be 7.2 km (4.5 mi) from Salamander Bay Shopping Centre and 18.8 km (11.7 mi) from Port Stephens Winery. Highlights at this campsite include in-room free WiFi, balconies, and LCD TVs.
You can enjoy sitting areas, ceiling fans, and hair dryers, featured in all 33 accommodations. In-room dining is easy with amenities like refrigerators, microwaves, and stovetops. Additionally, irons/ironing boards and free toiletries are available. Weekly housekeeping is available.
This campsite has an outdoor pool, free WiFi in public areas, and tour/ticket assistance. Additionally, you'll find laundry facilities. There's also the convenience of free self parking.
Places within a 15-minute drive of this 4-star Soldiers Point campsite include Toboggan Hill Park and Gan Gan Hill Lookout.Information missing or incorrect? Tell us!
Hotel Amenities
Hotel Amenities
Thou Walla Sunset Retreat features an outdoor pool, tour/ticket assistance, and laundry facilities. High-speed wireless Internet access is complimentary. Limited complimentary onsite parking is available on a first-come, first-served basis.
- Total number of rooms - 33
- Front desk (limited hours)
- Tours/ticket assistance
- Free WiFi
- Laundry facilities
- Parking (limited spaces)
- Free self parking
- Tennis on site
- Outdoor pool
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Free self parking, Parking (limited spaces)
Room Amenities
- Balcony
- Separate sitting area
- Ceiling fan
- Climate control
- Microwave
- Weekly housekeeping provided
- Private bathroom
- Free toiletries
- Hair dryer
- Iron/ironing board
- Cookware, dishware, and utensils
- Full-sized refrigerator/freezer
- Stovetop
- Free WiFi
Nearby Activities
The recreational activities listed below are available either on site or nearby; fees may apply.
- Snorkeling nearby
- Kayaking nearby
- Sailing nearby
- Scuba diving nearby
- Parasailing nearby
Hotel Policies
Check-in time starts at 2 PM
Minimum check-in age is 18
Special check-in instructions:
Check-out time is 10 AM
Payment types
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
Minimum guest age is 18
Caters to adults only
No pets or service animals allowed
We should mention
Guests under 18 years old are not permitted at this adults-only property. Some facilities may have restricted access. Guests can contact the property for details using the contact information on the booking confirmation. No pets and no service animals are allowed at this property.
National Rating
This property has been awarded a star rating from the Australian Star Ratings Agency, Star Ratings Australia.


text:
Highland Lakes News
Local news for Highland Lakes, NJ continually updated from thousands of sources on the web.
Vernon officials to meet with fire chiefs; council member argue over $5,000 'rent' cut
Tuesday Sep 29 | New Jersey Herald | Comment?
Hopatcong man admits resisting arrest
Friday Sep 25 | New Jersey Herald | Comment?
2 brothers plead guilty to robbery
Thursday Sep 10 | New Jersey Herald | Comment?
Updated: Sun Oct 04, 2015 12:11 am
Copyright © 2015 Topix LLC


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Stole this from my birth club thought it would be nice to see what the girls in my favorite groupĀare lusting after...
I would like...
-A bottle of peach or red berry ciroic (yes a whole bottle, dont judge me. LOL)
-My pants to button
-To go shooting
-To sleep through the night without getting up to pee
Be honest, What do you miss most???


text:
- Your Path:
- Home
- Sweet Safari Blue 1st Birthday High Chair Kit
- Large Image
This Sweet Safari high chair kit makes your son's seat look awesome!
You can make your son's Sweet Safari themed 1st birthday party more memorable by decorating his high chair with this Sweet Safari Blue 1st Birthday High Chair Kit. The kit includes a 31" mini flag banner, a 48" x 30" floor mat and a 12" x 12.5" bib. The products all feature fun patterns and are made of plastic. Please note: The kit does not include a high chair or adhesive.
- Includes:
- 1 Mini Flag Banner
- 1 Floor Mat
- 1 Bib
BirthdayExpress.com has tons of Sweet Safari Blue 1st Birthday party supplies that you can get to match this high chair kit. Just take a look at our matching plates, napkins, and more.Read More
- Product Number
- #77402
- Material
- Plastic
- Care Instructions
- Wipe Clean
- Air Shippable
- Yes
- Oversized
- No
- Express/Premium Surcharge
- $0.00
- Return Eligible
- Yes
- Available International
- Yes
Sweet Safari Blue 1st Birthday High Chair Kit
- Was:
- $0.00
- Price:
You Save %0 OFF
- Prod ID:
- 77402
- 4.5
- 3 Reviews
Discontinued Item
- We apologize for the inconvenience, but the product you're looking for has gone out of stock and is no longer available.
Orders placed by 2pm CT usually ship same day.
Customer Reviews
Sweet Safari Blue 1st Birthday High Chair Kit
3 Total Review
- Overall Rating:
- 4.5
- Write A Review
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Textured:no (?)
Multiple file formats
Up to 33% discount
Any custom adjustments
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Fiat Palio Fire Economy 2012 3d model was created on a real car base. Model of Fiat vehicle was made qualitatively and maximally close to the original.
If you need any other formats of Fiat car we will be more than happy to provide them for you.
Fiat Palio Fire Economy 2012 3d model is provided combined. You can get un-smoothed model after purchasing hatchback 3D model by contacting us. If you need you can easily replace and modify all main parts, colors, applied textures etc., because they are separated in Fiat Palio Fire Economy 2012 car model. We provide support for all of our models as well as for this vehicle 2010s, just contacts us with your request.
We hope our model Fiat hatchback satisfies your requirements and we can make any changes by your wishes.
* tires texture is not included into the set.
* all pictures were created with V-Ray rendering engine, (lighting setup is not included to model).
(unsmoothed format by your request)
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Traditional pilgrimages
Traditional pilgrimages in Puerto Vallarta Traditional festivities are celebrated in the month of December and Puerto Vallarta is no exception , starting the month with the most colorful guadalupanos celebrations. The traditional pilgrimage to the Virgin of Guadalupe celebrate in the main streets of downtown Puerto Vallarta exposing her great splendor.
- Published in Blog
Art, Galleries and more on Basilio Badillo, Puerto Vallarta
Puerto Vallarta has a long history as a favorite destination for art lovers, thanks to the artists who live and work here. Puerto Vallarta has been enriched and is known for new and innovative ideas in art and design. One of the places in Puerto Vallarta full of color and art is Basilio Badillo, located
- Published in Blog
Enjoy the Mantamar Beach Club Bar & Grill
One more place to enjoy in Puerto Vallarta, located a few steps from Hotel Posada de Roger, is the Mantamar Beach Club & Grill, which offers relaxing activities and fine gourmet food. Mantamar Beach Club Bar & Grill offers a number of selected amenities, including exclusive activities and classes that you won't find anywhere else
- Published in Blog
Old Town,Your Best Choice in PV
Did you know that many people who had previously stayed in large hotels or all-inclusive resorts are now staying in Old Town Puerto Vallarta? A variety of interesting small hotels are located in this area. Of course, one of them is the Hotel Posada de Roger! We offer a comfortable style, a place where you'll
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History of Posada de Roger
At the beginning of the seventies during a great moment of this seaport, Rogelio (Roger) Garcia Valdez, founder of Posada Roger, decided to take a chance and built a small inn [posada] with simple rooms and common bathrooms on Basilio Badillo street in an area which is known today as the romantic zone of Old
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The South Side Shuffle
ContentsThe South Side ShufflePuerto VallartaHotel Posada de Roger and get special promotions for this season.Here the dates of South Side ShuffleThe South Side Shuffle The South Side Shuffle is a street party of sorts, a "shindig" that takes place in colonia Emiliano Zapata of Puerto Vallarta every other Friday from 6 to 10 pm, in
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The Day of the Kings
In Mexico, as in all of Latin America, holidays differ from our North American neighbors. Mexican children do not receive Christmas presents on December 25th; they wait until January 6th, "el Día de Reyes," the Day of the Kings (or the Day of the Wise Men). The Magi who brought presents to the Baby Jesus,
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Fine Dining in Puerto Vallarta
The Puerto Vallarta restaurant scene is so surprisingly diverse and extensive you would have to go to a different restaurant every day for over a year to try them all! Naturally, Puerto Vallarta is a great place to discover an amazing variety of Mexican dishes, as well as succulent seafood, fusions of popular cuisines like Mediterranean and Oriental, along
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Tips for travelers
Mispacking is probably the easiest way to ruin a trip. Not having appropriate attire or toiletries, or having important items broken in transit can really spoil a trip. WHAT TO TAKE The number-one rule in packing for a trip, unless you have hired several football players to carry your gear for you, is to pack
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Hidden Beaches Puerto Vallarta
We present a list of the Best Tours that you can`t miss where you`ll find an unforgetable experience. The main tour yoy should take is "Hidden Beaches or Marietas Islands", it`s located just 30 minutes from Puerto Vallarta. How to get there? Take a boat from the Maritime Terminal in the Bay of Banderas up
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