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|This is the talk page for discussing improvements to the Phenethylamine article.
Article policies
|This article is of interest to the following WikiProjects:
|Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Phenethylamine.
- 1 Structural formula
- 2 Chemistry
- 3 Love drug
- 4 Etymology of the word 'Phenethylamine'
- 5 More on Etymology
- 6 Phenylethylamine used for psychoactive purposes
- 7 Dubious
- 8 Graphical overview
- 9 Relationship to Dopamine
- 10 Page title change request
- 11 solubility
- 12 Pronounciation
- 13 Suggestion for sub-topic, how phenethylamine is commercially produced
- 14 Inconsistency
- 15 Chocolate theory of love
- 16 Evidence that phenethylamine is in fact pharmacologically active
- 17 abuse and addiction
- 18 Review content to add
- 19 What are "Low dosages" of PEA? - A problem with the second passage of the article
- 20 I'm sort of chemistry illiterate, so...
- 21 Legal status UK
Structural formula[edit]
Regarding the term "structural formula", although I am not a chemist it is my understanding that this is the correct term (I am still open to be corrected if you think I'm mistaken in what follows). "Chemical structure" is kind of synonymous but really refers to the structure itself rather than a 2D (or 3D) diagram of the structure. The distinction is important because a structural formula is an incomplete representation since it doesn't specify the full 3D geometry, of even which optical isomer is being referred to. I don't have any books handy but a quick web search find support for this:
http://www.cartage.org.lb/en/themes/Sciences/Chemistry/Organicchemistry/StructuralFormulas/StructuralFormulas.htm http://dl.clackamas.cc.or.us/ch106-01/strform.htm http://sci-toys.com/ingredients/how_to_read_structural_formulas.html
The entries for chemical structure and structural formula need to be clarified. --Rkundalini 07:08, 24 Apr 2004 (UTC)
- Sorry, I must have been high on phenethylamine when I made this change. :)
- Delta G 13:11, 24 Apr 2004 (UTC)
what about DOC? this list is incomplete. —Preceding unsigned comment added by 126.96.36.199 (talk) 04:41, 4 November 2008 (UTC)
"Phenethylamine (PEA) is an aromatic amine (...)": it is not, it is an aliphatic amine. —Preceding unsigned comment added by 184.108.40.206 (talk) 12:58, 2 May 2008 (UTC)
- You are right, in aromatic amines the amino group is connected directly to the aromatic ring. --FK1954 (talk) 19:52, 25 September 2010 (UTC)
This is ture. DOC, or 2,5-dimethoxy-4-chloroamphetamine is missing from the table. 22.214.171.124 (talk) 15:45, 27 April 2009 (UTC)
Love drug[edit]
I have removed the claim that some "scientists" believe phenethylamine is implicated in feeling in love. As far as I know this is almost certainly false speculation that's only been promulgated because it makes for a cute story for journalists who like to pretend that scientists understand everything including the chemical formula for love ;). See e.g. the PiHKAL entry for phenethylamine [1]. If you can find some verifiable sources saying who originally made this claim and what others have said about it then put it back in the article, otherwise it should stay out IMO. --Russell E 22:10, 15 January 2006 (UTC)
- Although a rocket scientist and not expert on polypeptides, I want to add to this discussion that PEA or the phenethylamines do appear to be involved in libido enhancement. So, although scientific proof may be lacking, I think it is fair to say that this is some of the most interesting scientific research going on today, and is likely to change the way we look at love and human emotional interactions. We dont have to wait for science to "prove" something to understand that these chemicals obviously are involved in our feelings, and may be the major determinator of our behavior. This is not dull and dry science indeed! 220.127.116.11 22:50, 3 February 2006 (UTC) Duane Barker
- Although certain phenethylamines such as dopamine play a key role in increasing feelings of empathy and love, I don't think the "love molecule" sentence in the beginning of the article adds anything of importance to the issue (and as such, I have removed it.) Refault 08:32, 10 May 2006 (UTC)
- Some mention should be added to the article, stating the claimed relationship and that it's not considered solid science, if only for the sake of the many who come to Wikipedia to look it up and don't know how Talk pages work. That way, they get *something*. 126.96.36.199 20:43, 20 March 2007 (UTC)
- There is a large amount of scholarly literature pointing to phenylethylamine as one of the chemicals that are important in love. Are these all mis-citing a single source? I think someone knowledgeable should survey the literature and see if it's legit. If it's not, then we're doing a disservice to not include this material in this article. Either way, there is so much literature mentioning the relationship that even if it is false, it deserves mention in this article (along with whatever reasons why people reached false conclusions). Cazort (talk) 13:05, 24 January 2008 (UTC)
See: http://www.scq.ubc.ca/is-there-a-neurochemical-basis-for-falling-in-love/
However, no empirical data has been found to date that strongly supports the PEA theory of romantic love, and it has subsequently been suggested that different physiological mechanisms are involved in the early stages of falling in love (Marazziti and Canale, 2004).
Igottheconch (talk) 17:31, 14 May 2013 (UTC)
Etymology of the word 'Phenethylamine'[edit]
It is interesting to note that the word 'Phenethylamine' contains concatenations of the words (or rather chemicals) phenyl, ethyl and amine. I think this fact should be included into the article. Thank you. —Preceding unsigned comment added by 220.127.116.11 (talk) 23:48, 7 September 2007 (UTC)
- I disagree... The etymology of a huge majority of organic compounds is made up of the different functional groups, but I don't believe it is worth mentioning for them either. In the chembox you will notice "Chemical name 2-Phenylethylamine", the wikilink describes how compounds are named, so that it need not be mentioned in every chemical article. --Mark PEA 15:15, 8 September 2007 (UTC)
Concur with the above, that's just pretty standard chemiclature. How amazing, benzoic acid contains benzene and acid! —Preceding unsigned comment added by 126.96.36.199 (talk) 16:04, 2 April 2010 (UTC)
More on Etymology[edit]
What about mentioning the fact that the word Amphetamine is composed of the following components:
Following this model, Phenethylamine is a [ph][et][amine] as are all substituted Phenethylamines. As the word Amphetamine has such a stigma attached to it in our culture I'd like to see the point made that the Catecholamine neurotransmitters/hormones Adrenaline, Noradrenaline and Dopamine are also Phetamines and share many sympathomimetic attributes with Amphetamines. I just find this line of reasoning very interesting, but I don't feel qualified to edit the article text myself.
Special:Contributions/Sturu (talk) 21:51, 24 January 2008 (UTC)
- Added section, here is a cached edit of it incase it gets deleted. Feel free to improve, shrink, or discuss deletion. Though I thank it is valid to point out the fact phenylethylamines are important compounds with similar actions to the so called devil drug amphetamine. Here you go http://en.wikipedia.org/w/index.php?title=Phenethylamine&oldid=225886772#Relation_to_amphetamine. C6541 (talk) 21:36, 15 July 2008 (UTC)
Phenylethylamine used for psychoactive purposes[edit]
I have taken PEA in doses of 1 - 4 grams and it is definitely psychoactive. I can feel even 1g on an empty stomach, and cannabis and coffee seem to potentiate it strongly. It does not last long, around 20 minutes total depending on dose, but if enough is taken the effects are EXTREMELY intense and far more powerful than amphetamine. The effects are very unique, like a psycho-stimulant/enactogen but also different, and it feels extremely fast and speedy but there is almost no anxiety or jitteriness at all. There is not very much euphoria. It starts with a rush that lasts 5 minutes or so and comes on suddenly. PEA binds to sigma receptors so maybe that's what produces the unique effects. It does however feel somewhat toxic and hard on my body, like it's extremely acidic, for the duration. Also mixing MAOI-B's with PEA is very dangerous and addictive and people should not try it. 184.108.40.206 (talk) 23:18, 23 July 2011 (UTC)
PEA is metabolised before it can have a noticable effect on the CNS. Adding an Mao-b inhibitor will allow the PEA to stimulate the CNS. Personal experience indicates the effect is short lasting and noware near as stimulating as Amphetamine at normal doses, though in high doses it is much more stimulating and is comparable to cocaine/methamphetamine when high levels of Mao-b inhibiting drugs along with PEA are used. —Preceding unsigned comment added by 18.104.22.168 (talk) 12:54, 4 November 2008 (UTC)
hello, you mention that there are several reports of the use of high quantities of PEA (up to 4g) in th US. could you please give references for that? On e.g. Erowid no trip reports are listed. that would be very fine!! thank you. —Preceding unsigned comment added by 22.214.171.124 (talk) 17:04, 26 June 2008 (UTC)
Edit: I would also mention the discussion on the thread on the bluelight.ru forum: http://www.bluelight.ru/vb/showthread.php?t=383096 there it was assumed that this text (identical with the text herein) was posted probably to make propaganda only. it probably was posted there from the guy who wished to sell PEA over a web-shop. so could it be questionable to put this text here in wikipedia as it is?! better write a discussion, and that Sasha Shulgin showed no effects up to 1.6g, and about this mystery. —Preceding unsigned comment added by 188.8.131.52 (talk) 17:18, 26 June 2008 (UTC)
- Occasionally people add things to this page such as that PEA is active, but as you say, it is probably people selling the product. When a reliable source is posted with a claim, then I will believe it. --Mark PEA (talk) 10:39, 27 June 2008 (UTC)
126.96.36.199 (talk) 09:12, 6 August 2008 (UTC)If you do a search on Bodybuilding.com forum there's over 30 logs on PEA reporting effects. While they could all be lying it seems abit weird. I think everyones PEA experience probably varies due to different levels of MAO-B in the brain and it seems to not work when food is taken. I'll probably try this at some point since there's no reason not to try it. M&M has some logs maybe you guys can ask them some questions?
doom3q's Log http://www.mindandmuscle.net/forum/index.php?showtopic=34528
djremix's Log http://www.mindandmuscle.net/forum/index.php?showtopic=34541
gotDOMS's Log http://www.mindandmuscle.net/forum/index.php?showtopic=34484
Sup3rman's Report http://www.mindandmuscle.net/forum/index.p...st&p=489168
BlackFlag's Log http://www.mindandmuscle.net/forum/index.php?showtopic=34431
Raymond333's Log http://www.mindandmuscle.net/forum/index.php?showtopic=34461
Necrosis's Log http://www.mindandmuscle.net/forum/index.php?showtopic=34513 22.214.171.124 (talk) 09:12, 6 August 2008 (UTC)
- Wikipedia does not accept original research as reliable. The reason for this is that it can be anecdotal, and anecdotal evidence can be unreliable due to cognitive biases, especially the placebo effect --Mark PEA (talk) 14:19, 28 August 2008 (UTC)
- Shulgin found no effects up to 1600 mg and 50 mg i.v.
http://www.erowid.org/library/books_online/pihkal/pihkal142.shtmlAlkaloidMan (talk) 19:27, 28 October 2010 (UTC)AlkaloidMan
Added a dubious section as the statements made go against scientific conventional wisdom that PEA has no psychoactive effect, and this is an issue for Wikipedia as it may be targeted by those trying to improve the sales of their product, for example. --Mark PEA (talk) 18:49, 2 August 2008 (UTC)
I think it's interesting that the original post has a footnote for its claims, whereas your objections are based on "scientific conventional wisdom." At the very least if you think the claim is dubious then you should cite something saying so and not rely on "conventional wisdom" to overcome something documented. I personally think your dubious section should be removed unless you provide some documentaion of your claim.220.127.116.11 (talk) 16:10, 23 August 2008 (UTC)
- The problem for me was that one of the citations doesn't even have an abstract, so is kind of useless to me as I can't read what the study says. The other problem is that though the 2 studies discuss the effects of endogenous phenethylamine, it is implied in the article that exogenous phenethylamine can have these same effects, when "conventional scientific wisdom" (which has derived from countless studies) says that PEA is rapidly metabolized by MAO present in the gut and CNS. A big problem with Phenethylamine is that many online vendors are making it out to be psychoactive to make a profit from it. I honestly cannot be bothered to keep editing out these claims. --Mark PEA (talk) 14:14, 28 August 2008 (UTC)
- I tend to agree with this. If you look at the claims made at http://neuro.psychiatryonline.org/cgi/content/abstract/8/2/168 - another article with Sabelli's name on it, you'll see some rather far-reaching claims made for PEA/MAOI therapy, such as "PEA improves mood as rapidly as amphetamine but does not produce tolerance." In the absence of a much more massive study or a very involved explanation as to why PEA is so much like amphetamine, but yet magically, is not in like it at all in it's negative effects, its a whole lot more logical to conclude that the study participants must have been influenced, at least indirectly, by Sabelli's obvious enthusiasm for this compound. Even a double-blind study wouldn't do much to prevent this, as if the substance has any effect, chances are the patients involved would be able to figure out if they were in a placebo group or not. Even incorporating an active placebo would be difficult here.
- Still, it is a compound worth researching, both because its endogenous and because it is totally possible that some alternative drug-delivery method (besides outright MAO suppression) could make this into a subpart of a viable therapeutic psychoactive compound someday.126.96.36.199 (talk) 19:16, 12 September 2008 (UTC)
- Is this not already the case? Amphetamine is PEA with a methyl group attached to it. It seems to me that the methyl group performs the same function as the MAO-B inhibitor in MAOI/PEA therapy: it slows down the elimination of the substance. (Methamphetamine takes this one step further, by adding another methyl group, and has a correspondingly longer half-life.) René van Buuren (talk) 14:38, 10 December 2008 (UTC)
- Not agreeing or disagreeing - interested only in accuracy. But in this regard, read more carefully what the intro to the article says about MAO acting on PEA (emphasis added): "However trace amounts from food are quickly metabolized by the enzyme MAO-B, preventing significant concentrations from reaching the brain." Maybe the therapeutic effects can be produced by ingesting large amounts of PEA, overwhelming MAO? Just asking. Wlegro (talk) 14:53, 2 December 2008 (UTC)
- It certainly seems that way to me. I've taken up to 2.5 g of pure phenylethylamine hydrochloride powder before (dissolved in drinks); there is a strong stimulant effect from 1.5 g or so, and it gets very euphoric above 2 g, though it only lasts for about 45 minutes. I've never taken illegal stimulants, but it does feel the way I imagined amphetamines would. (Obviously this is anecdotal evidence, but I think it does answer your question.) René van Buuren (talk) 14:38, 10 December 2008 (UTC)
- I can confirm this from first hand experience. The body only has a finite number of MAO-B enzymes. Flooding them with too much PEA allows considerable portions to reach the brain. 1.6 grams if you're 130 pounds to 2 grams if you're 150 pounds to 2.5 grams if you're 180 pounds seem to be the ideal levels based on numerous experiments on myself and my friends. Not sure if the relationship is linear. The effect is markedly different if taken with alcohol though. This is odd, because alcohol also increases PEA levels, but it doesn't feel anything like a PEA overdose. It actually feels quite good. In any case, the initial effects produced are nothing like amphetamine. There is a somewhat amphetamine like euphoria for about an hour afterwards, but this is only experienced if you've taken caffeine beforehand to mitigate the ridiculous wish for a nap on the comedown. —Preceding unsigned comment added by 184.108.40.206 (talk) 03:38, 15 April 2010 (UTC)
- Regardless of whether or not this method would actually work (I have no idea), overwhelming your body's supply of MAO enzymes to the point of exhaustion would be extremely dangerous. This article reads way too much like an advertisement than is appropriate for Wikipedia's NPV requirement among others.188.8.131.52 (talk) 01:06, 9 January 2011 (UTC)
- I can confirm this from first hand experience. The body only has a finite number of MAO-B enzymes. Flooding them with too much PEA allows considerable portions to reach the brain. 1.6 grams if you're 130 pounds to 2 grams if you're 150 pounds to 2.5 grams if you're 180 pounds seem to be the ideal levels based on numerous experiments on myself and my friends. Not sure if the relationship is linear. The effect is markedly different if taken with alcohol though. This is odd, because alcohol also increases PEA levels, but it doesn't feel anything like a PEA overdose. It actually feels quite good. In any case, the initial effects produced are nothing like amphetamine. There is a somewhat amphetamine like euphoria for about an hour afterwards, but this is only experienced if you've taken caffeine beforehand to mitigate the ridiculous wish for a nap on the comedown. —Preceding unsigned comment added by 22.214.171.124 (talk) 03:38, 15 April 2010 (UTC)
- It certainly seems that way to me. I've taken up to 2.5 g of pure phenylethylamine hydrochloride powder before (dissolved in drinks); there is a strong stimulant effect from 1.5 g or so, and it gets very euphoric above 2 g, though it only lasts for about 45 minutes. I've never taken illegal stimulants, but it does feel the way I imagined amphetamines would. (Obviously this is anecdotal evidence, but I think it does answer your question.) René van Buuren (talk) 14:38, 10 December 2008 (UTC)
The need for substituents on the phenyl group seem to be a necessity for CNS activity especially at the 4-position or at minimum a tri-substitution usually involving the 2 and 4 position. Work done by Nichols et al. have provided insight with their homology model of 5-HT2A as well as biochemical assays that show a hydrogen at the 4-position greatly diminishes binding at the 5-HT2A receptor. I would then make the extrapolation that having no substitutions on the phenyl ring would pretty much reducing any binding to above micromolar concentrations which is essentially no substantial binding. Please read J. Med. Chem. 1996, 39, 2953-2961 as well as J. Comput.-Aided Mol. Des. 2002, 16, 511-520. Trimethoxy (talk) 20:39, 26 August 2008 (UTC)
I put a dubious tag on "Antidepressant drug therapy is an indirect (pharmacological) "replacement" of brain phenylethylamine." mostly because it's quite an inflammatory statement, and the study is unavailable for access.126.96.36.199 (talk) 03:50, 20 June 2009 (UTC)
http://neuro.psychiatryonline.org/cgi/content/abstract/8/2/168 I would hardly consider a trial on 14 people, with no controls or blinds, and when subjects were already taking a known antidepressant worthy enough evidence to suggest that PEA has notable psychoactive effects —Preceding unsigned comment added by 220.127.116.11 (talk) 04:24, 14 December 2010 (UTC)
I read the Sabelli/Borison/Diamond/etc. article and fixed an incorrectly quoted line about "increasing brain levels 1000-fold when taken with a MAOI and 3-4 times when taken by itself." That is simply not what the author stated. I fixed the line to what it should be (a MAOI increases concentration a 1000-fold if brain concentration were low initially and by 3-4 times if concentration was already high). —Preceding unsigned comment added by 18.104.22.168 (talk) 01:13, 8 April 2011 (UTC)
- Dear Mark PEA and others: Due to my involvement in academia, I have unlimited pubmed (and others) access. I already have the two documents sitting on my hard drive. I really don't have time to look at them just now and then speculate on here about their contents. Whats the appropriate way of getting them to you? I'm rather certain it would be a violation of copyright law to upload them on my server and post a link here? How about this, you drop an email address in my talk page or wiki-mail with a little note like 'PEA Docs' so I know what its regarding, and Ill email them on over or provide an http link if you prefer? Certainly, given the limited distribution and context in which they are being used would be acceptable. Especially when one considers that most publishers will likely give limited free access to students for, or document for research if you simply ask. Furthermore, are none of you enrolled at a university? If so, chances are high that your student enrollment can benefit you free access to most pubmed documents, just ask at the library, might allow access through their website, you can even log in from home and download till your hard drive chokes. Let me know.
- DrBurningBunny (talk) 13:24, 22 April 2011 (UTC)
- Dear DrBurningBunny: I applaud your respect of the copyright of the documents in question, and your efforts to assist others in accessing them without violating any laws. I do find it interesting that you have the time to post on this talk page and offer to share them upon request but not to look at the documents, but without the ability to view them myself I can't know how time consuming that might be. Regardless, the statement tagged as dubious by user 18.104.22.168 ("Antidepressant drug therapy is an indirect (pharmacological) "replacement" of brain phenylethylamine.") no longer appears in the article; the dubious tags are currently only applied to the statements about the half-life of phenylethylamine and the potential increases of its brain levels by MAOIs and alcohol or THC. Are these statements not verifiable? They don't seem particularly controversial and I don't see a mention of them on this discussion page, can those dubious tags be removed? 184.108.40.206 (talk) 08:18, 9 October 2011 (UTC)
Graphical overview[edit]
Is it just me or is this all wrong? Compare, for example, methamphetamine's picture to http://en.wikipedia.org/wiki/Image:Methamphetamine-2D-skeletal-.svg --22.214.171.124 (talk) 20:11, 10 September 2008 (UTC)
- No, it isn't just you... this graphic has several errors in it. You cited methamphetamine as a wrong example; amphetamine itself isn't correct!!! The amine and the terminal methyl need to be switched in many of the compounds shown. I would condone removing this graphic unless someone could point out how those structures are correct. --22.214.171.124 (talk) 03:20, 10 October 2008 (UTC)
- The structures aren't wrong. They are just different ways of representing the same molecule. The connectivity remains the same in each case. In a way, they depict different conformations of the same chemical structure. -- Ed (Edgar181) 12:51, 10 October 2008 (UTC)
- They are not different conformations, per se, they are just rotations around the alpha-carbon.Trimethoxy (talk) 20:31, 16 December 2008 (UTC)
- The structures aren't wrong. They are just different ways of representing the same molecule. The connectivity remains the same in each case. In a way, they depict different conformations of the same chemical structure. -- Ed (Edgar181) 12:51, 10 October 2008 (UTC)
Relationship to Dopamine[edit]
The introduction refers to dopamine as "this phenethylamine" (PEA), suggesting that "phenethylamines" are a class of related chemicals. However, the article on PEA seems to describe PEA as a specific chemical. I think this needs to be clarified. Attys (talk) 06:14, 7 December 2010 (UTC)
- PEA refers both to the chemical in this article and a group of structurally related chemicals. This is covered in the lead of this article. Every link referring to the group should go to substituted phenethylamines, but that article may be doomed.
ButOnMethItIs (talk) 12:16, 7 December 2010 (UTC)
- Phenethylamine is both an active psychotropic compound (though not potent without some sort of MAOI co-administered. As well as a class of chemicals (Phenethylamines). This should already be made clear in the early parts of the wiki. ***slow pony*** ~_~ 184.108.40.206 (talk) 14:34, 27 January 2011 (UTC)220.127.116.11 (talk) 14:37, 27 January 2011 (UTC)
Page title change request[edit]
Correct (full) substance chemical name is "phenylethylamine". Only abbreviated [or sometimes referred to] as "phenethylamine".
That's why I am requesting [editors with admin privileges] to change the page title to reflect full chemical name: "Phenylethylamine".
Thanks for listening. ;-)
MDGx☹☺ 19:37, 19 April 2011 (UTC)
- I concur. Just wanted to raise my hand in support of this suggestion.Kailey elise (talk) 18:14, 26 April 2011 (UTC)
Predicted Water Solubility 2.19 mg/mL [Predicted by ALOGPS] http://www.hmdb.ca/metabolites/HMDB12275 --Ryan W (talk) 07:41, 20 February 2012 (UTC)
how is it pronounced? would be good to have that here. A few people i know are calling it crazy things such as "pen-ate-mine" and "pee-nth-lime"
would "fen-eth-el-ah-meen" be correct? im not sure on wikipedia's standards for pronouncing it — Preceding unsigned comment added by 126.96.36.199 (talk) 06:37, 10 April 2012 (UTC)
Suggestion for sub-topic, how phenethylamine is commercially produced[edit]
An addition to this article that I would find interesting is the process by which PEA is manufactured for commercial use.220.127.116.11 (talk) 03:10, 5 May 2012 (UTC)
This article is inconsistent with intimate relationship. If this is correct, that one should be edited. 220.127.116.11 (talk) 18:36, 17 June 2012 (UTC)
Chocolate theory of love[edit]
While skeptical myself, the sources indicate phenethylamine does not reach the brain in *significant* concentrations. There is no citation indicating that phenethylamine never reaches the brain in any concentration. The phrase, "[metabolized,] preventing significant concentrations from reaching the brain, thus contributing no perceptible psychoactive effect without the use of an MAOI" is therefore contradictory. If some amount of phenethylamine present in chocolate is digested and able to reach the brain, even if not psychoactive, it is at least a plausible hypothesis for the so called "chocolate theory of love". 22.214.171.124 (talk) 14:29, 28 July 2013 (UTC)
Evidence that phenethylamine is in fact pharmacologically active[edit]
Animal studies indicate phenethylamine is pharmacologically active despite its short half life. This includes routes of administration through the stomach (intragastric, intraduodenal) as well as intravenous routes of administration. These studies indicate PEA levels increase throughout the body -- including the brain -- but with the exception of the liver. They also indicate habituation / self-administration in dogs and rats. Other pharmacological features of PEA include increased blood pressure.
184.108.40.206 (talk) 20:26, 28 July 2013 (UTC)
abuse and addiction[edit]
I added this section a few days ago. I see that someone has added a tag suggesting that original research was used in it. That's false, and as such I'm going to remove that tag. None of the research is original, based entirely on what I've read.
I do get the unreliable source thing. However, when it comes to abuse and addiction to obscure compounds, unfortunately there's almost nothing in the official literature. Occasionally there are case studies published on these things, but they've become less common. Since this sort of recreational drug abuse won't ever occur on any sort of widespread basis. Additionally, because this abuse and addiction is purely the result of speculation on the sorts of forums I've cited. If it weren't for these forums, information of the abuse potential of the combination wouldn't have spread of it weren't for these forums. As a result, these are the most reliable source of information on the topic. These forums are used by the government in monitoring drug trends and identifying new drugs abuse, it's logical and reasonable to reference them. The statements in these posts aren't used to draw conclusions, but only to make statements about individual expesriences- exactly what they'd be useful for were they used in a case study. — Preceding unsigned comment added by 22.214.171.124 (talk) 09:19, 21 November 2013 (UTC)
- I didn't tag that section, but I agree that a forum of personal experiences is original research - it's also not a reliable source per the stricter MEDRS criteria which applies to all medicine-related articles. The types of sources which you could use to cite that paragraph would be reviews like PMID 7906896. I've read newer reviews which state the same thing you wrote, but what's currently cited isn't suitable as a source for this article. Seppi333 (talk) 19:20, 21 November 2013 (UTC)
Review content to add[edit]
Seppi333 (Insert 2¢ | Maintained) 07:19, 24 June 2014 (UTC)
What are "Low dosages" of PEA? - A problem with the second passage of the article[edit]
The very second passage of the article ends with the sentence: "however, orally ingested phenethylamine experiences extensive first-pass metabolism by monoamine oxidase B (MAO-B), which turns it into phenylacetic acid. This prevents significant concentrations from reaching the brain when taken in low doses.[4][5]".
Indeed - A clarification is needed: What are these "Low doses" the article mention? I don't have an access to the listed articles from the PC (and seemingly won't have easy access anyhow in the next weeks), But someone who can should take care of this asap.
Another thing that should be clarified is if very similar molecules (like Phentermine for example), goes through the same metabolic processes... Thanks, Ben-Natan (talk) 01:08, 3 December 2014 (UTC)
- We're actually not supposed to specify a specific dose in articles per WP:MEDMOS, but to answer your question here: the paper linked in the section above this lightly covers the neuropsychological effects of oral PEA in humans. The psychoactive dose of PEA varies by individual - mostly due to individual differences in MAO-B expression/activity; it can enter the brain since it's quite plasma-soluble and easily crosses the blood-brain barrier (and membranes in general). In individuals with no drug tolerance to TAAR1 agonists, the above ref notes that 500 mg can induce noticeable cognitive effects in some people, though I imagine for others it might be on the order of 1-2 grams (re: MAO-B variability). PEA is regulated as a dietary supplement and sold commercially (e.g., Amazon's search results), so you can technically see for yourself if you're not convinced. It's more potent than amphetamine at modulating dopamine neurotransmission, so a psychoactive dose will induce a blatantly obvious effect (e.g., euphoria, motivated behavior, increased arousal, etc), despite being rather transient due to the half-life.
- W.r.t. the second question, α-methylated PEA derivatives (amphetamine - i.e., α-methylphenethylamine - is the parent of these; phentermine is amphetamine with an additional α-methylation - i.e., α,α-dimethylphenethylamine) are quite robust to metabolism by MAO-B (see Phenylpropanolamine#Chemistry for more on the structure-activity relationship of some PEA substitutions). In contrast to PEA, substituted amphetamines generally are metabolized primarily by CYP2D6. The other methylphenethylamines (and some of their derivates) are all metabolized by MAO-B, similar to PEA. Seppi333 (Insert 2¢ | Maintained) 06:52, 3 December 2014 (UTC)
I'm sort of chemistry illiterate, so...[edit]
@DMacks: Did I say anything stupid in this edit? Seppi333 (Insert 2¢ | Maintained) 11:49, 10 March 2015 (UTC)
- Looks fine. That specific example comes from the cited ref. And this method is not one of the "Alternative syntheses are outlined in the footnotes" of the OrgSyn ref. With so many different methods available, probably should have some criteria for deciding what to illustrate. For example, being an OrgSyn prep is a pretty strong assertion of value, rather than just being a primary scientific-lit ref. DMacks (talk) 12:01, 10 March 2015 (UTC)
- Ah. I merely included it because it's the only usable synthesis diagram on Commons for enwiki... and I felt like the phys/chem section could use a little expansion since it's dwarfed by the pharmacology section. Seppi333 (Insert 2¢ | Maintained) 13:35, 10 March 2015 (UTC)
- I'll work on some synth diagrams. Definitely will do OrgSynth (a gold-standard for synth). Others seem merely mechanistic studies, making this among many other similar compounds to demonstrate a certain new reaction (for example, the JACS ref for LiAlH4), rather than as a citedly valuable route for this particular chemical. A useful one would be if there is a most recent discussion in secondary lit, or the current commercially- or illicitly-used routes. PiKHAL mentions reduction of benzyl cyanide and decarboxylation of phenylalanine as the two major industrial routes (without comment about what reagents are used). DMacks (talk) 18:56, 11 March 2015 (UTC)
- Ah. I merely included it because it's the only usable synthesis diagram on Commons for enwiki... and I felt like the phys/chem section could use a little expansion since it's dwarfed by the pharmacology section. Seppi333 (Insert 2¢ | Maintained) 13:35, 10 March 2015 (UTC)
Legal status UK[edit]
It must be a mistake that the legal status of phenethylamine is "Class A" in the UK. Or is chocolate now illegal in the UK?!?
If it would be true, then the next step would be a ban on phenylalanine, because of being a precursor of phenethylamine -> phenylalanine is an essential amino acid => no phenylalanine, no human life possible
Regards, Stefan --Stefan Bach7777 (talk) 21:05, 16 April 2015 (UTC)
- Drugs controlled by the UK Misuse of Drugs Act#Class A drugs says compounds "structurally derived from phenethylamine" are banned but it doesn't say anything about phenethylamine itself. I'll change this. Sizeofint (talk) 23:44, 16 April 2015 (UTC)


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- Repayment Term
- 14 months (Additional Information)
- Repayment Schedule
- Monthly
- Pre-Disbursed:
- May 19, 2014
- Listed
- Jun 18, 2014
- Currency Exchange Loss:
- Ended:
- May 17, 2015


text:
381 Views 1 Reply Latest reply: Oct 4, 2012 1:20 PM by Bob Timmons
Bob Timmons Oct 4, 2012 1:20 PM
Re: is the HP OfficeJet J6413 support air printing? in response to abirgil Solved
Unfortunately, the HP J7413 does not appear to support AirPrint. See this Apple Support document for more details:
If you need to print from your iPhone, another App like Print Central might possibly allow you to do this:


text:
Review all of the information we have provided for the clinics. Some of them provide a wide array of services ranging from free to sliding scale services.
We have provided as much detailed information including phone numbers, emails, and websites where available.
Clinic services we list include:
Dental Clinic Services
Medical Clinic Services
Women's Health Clinic Services
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Ks Shawnee Clinic - Shawnee
Clinic services provided: - Primary Family Care- Full laboratory and Immunizations- Vaccines for children's program- Acute and Chronic care- Preventative healthcare and education- Specialty care includes pediatrics, asthma/allergy and diabetes management It is our mission to provide healthcar see clinic details
Platte County Health Department Parkville Office - Parkville
Location: 13 miles from ShawneeParkville, MO - 64152
This organization offers FREE STD TESTING. This may not be a clinic that offers other medical services.Monday: 8:00am - 6:00pm Tuesday: 8:00am - 6:00pm Wednesday: 8:00am - 6:00pm Thursday: 8:00am - 6:00pm Friday: 8:00am - 6:00pmChlamydia Test Conventional HIV Blood Test&nbs see clinic details
Duchesne Clinic - Kansas City
Location: 10 miles from ShawneeKansas City, KS - 66101
(913) 321-2626
Provide primary health care, chronic disease management and medication assistance to very low-income uninsured residents Wyandotte County.Services:Primary Health CareChronic Disease ManagementMedication AssistanceSpecialty CareSocial ServicesPrior to accessing services, individuals must qualify for see clinic details
Turner House Children's Clinic - Kansas City
Location: 9 miles from ShawneeKansas City, KS - 66102
(913) 342-2552
Pediatric health care for ages 0 - 18 years old. Turner House serves an ethnically and racially diverse population with culturally competent, bilingual care. Nearly 90% of patient families are Spanish speaking. More than 88% live at or below the federal poverty level, earning less see clinic details
Kansas City Free Health Clinic - Kansas City
Location: 10 miles from ShawneeKansas City, MO - 64111
(816) 531-5144
The purpose of the Kansas City Free Health Clinic is to promote health and wellness by providing quality services, at no charge, to people without access to basic care. see clinic details
The Medina Clinic - Grandview
Location: 16 miles from ShawneeGrandview, MO - 64030
The Medina Clinic, founded in 2009, is a charitable organization dedicated to providing low cost outpatient medical care as a community service to the residents of Jackson county, Missouri, and surrounding areas. We see patients for consultations regarding a range of medical conditions. By offering see clinic details
Golden Livingcenter Edwardsville - Edwardsville
Location: 4 miles from ShawneeEdwardsville, KS - 66111
(913) 441-1900
This skilled nursing facility is located in Edwardsville, Kansas near the Kaw River and less than five miles from Providence Medical Center. At Edwardsville, they are proud to provide compassionate, individualized care. Their LivingCenter focuses on mental health services, and they believe in the im see clinic details
As an enhancement to our free medical clinic listings we now provide sliding scale treatment clinics. Sliding fee scale are variable prices for services due to customers ability to pay. Medical and dental fees are reduced due to many factors. That is why you need to call the clinic directly on these sliding fee scale clinics.
We also provide income based clinics. These clinics are HRSA Health Centers. You pay what you can afford based on your income.
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1-20 of 39 items from 2015 « Prev | Next »
20 August 2015 11:57 AM, PDT | Deadline | See recent Deadline news »
Exclusive: Talk about art imitating life. A writer/director who was pronounced clinically dead twice in his life and experienced an unusual phenomenon when he was "dead," has written a semi-autobiographical film about his experience with Brendan Fraser playing a key role and Marcia Cross playing a character called 'The Boss' which is really God. Behind the Curtain of the Night, written/directed by Dalibor Stach, follows a boy who drowns when he is six years-old and has a… »
12 August 2015 9:35 AM, PDT | Flickeringmyth | See recent Flickeringmyth news »
It's hard to argue that one of the most shocking Academy Award upsets of all time happened close to a decade ago, when Crash took home Best Picture over Ang Lee's Brokeback Mountain (and three other nominated films hailed as more deserving) at the 2006 Oscars. Considering that many were even surprised to see the movie nominated in that category in the first place, its win outraged film fans everywhere.
In a new interview with HitFix, writer/director of the film Paul Haggis, who also garnered an Oscar that night for Best Original Screenplay, admits that even he wouldn't have picked Crash for the coveted award.
Haggis was asked about the criticism directed at the film, to which he replied, "Was it the best film of the year? I don't think so. There were great films that year. Good Night, and Good Luck, amazing film. Capote, terrific film. »
- Justin Cook
12 August 2015 4:33 AM, PDT | Den of Geek | See recent Den of Geek news »
Sergio Leone and Joe Dante at one stage were linked with The Phantom. We look back at Billy Zane's moment in the superhero spotlight.
"Where's your spirit of adventure?" asks Drax, the film's villain, before setting off in search of the final skull of Touganda. This sums up The Phantom nicely. It might not work, but they went on an adventure and tried something interesting and different. Cinema would be richer with a greater sense of adventure. That said, the spirit of the film being expressed by the villain does serve as an example of what a muddle the team behind The Phantom movie got themselves into.
The 1996 film The Phantom is a bit of an oddity. It gets a lot of stuff really wrong, yet there are other areas where it comes up with a really interesting approach to the challenge of making a comic adaptation. It »
- simonbrew
11 August 2015 5:17 PM, PDT | DreadCentral.com | See recent Dread Central news »
I'm probably one of the few people on the entire planet who genuinely enjoys the Mummy flicks starring Brendan Fraser. Although they're more Indiana Jones-esque in nature, there were just enough genre elements for some to classify these flicks as… Continue Reading →
The post Director Alex Kurtzman Says Mummy Reboot Is Still a Horror Movie appeared first on Dread Central. »
- Todd Rigney
11 August 2015 12:13 PM, PDT | Flickeringmyth | See recent Flickeringmyth news »
In the aftermath of this weeks disastrous Fantastic Four release, David Opie argues that reboots are still essential to modern day filmmaking…
Remake. Reimagining. Reboot. The Three dreaded R's of Hollywood.
Every day, it seems that studios announce plans to launch yet another a new franchise reboot and every day, the internet responds with a collective groan louder than the sound of Fantastic Four crashing and burning at the box office.
See Also: Fantastic Four Clobbered At The Box Office
"How dare they mess with a classic!?"
"Is there no originality left in Hollywood!"
"Too Soon!"
In the harshest backhanded compliment ever given, critics are describing the new Fantastic Four movie as the best so far, yet the reviews are overwhelmingly negative, seemingly confirming the fears that fans held about the project ever since it was first announced. Fantastic Four isn't the only reboot suffering from a backlash though. »
- David Opie
5 August 2015 11:27 PM, PDT | Alt Film Guide | See recent Alt Film Guide news »
Michael Caine young. Michael Caine movies: From Irwin Allen bombs to Woody Allen classic It's hard to believe that Michael Caine has been around making movies for nearly six decades. No wonder he's had time to appear – in roles big and small and tiny – in more than 120 films, ranging from unwatchable stuff like the Sylvester Stallone soccer flick Victory and Michael Ritchie's adventure flick The Island to Brian G. Hutton's X, Y and Zee, Joseph L. Mankiewicz's Sleuth (a duel of wits and acting styles with Laurence Olivier), and Alfonso Cuarón's Children of Men. (See TCM's Michael Caine movie schedule further below.) Throughout his long, long career, Caine has played heroes and villains and everything in between. Sometimes, in his worst vehicles, he has floundered along with everybody else. At other times, he was the best element in otherwise disappointing fare, e.g., Philip Kaufman's Quills. »
- Andre Soares
13 July 2015 11:30 AM, PDT | E! Online | See recent E! Online news »
Imagine what could have been! Before Henry Cavill was cast as Superman in 2013's Man of Steel—a role he is reprising opposite Ben Affleck in 2016's Batman v Superman: Dawn of Justice—there was another actor in the running for the hottest role in Hollywood: Matt Bomer. As the 37-year-old star himself recently revealed in Josh Horowitz's Happy, Sad, Confused podcast, "I had screen tested with Amy Adams in the tights. I think at that session it was Paul Walker, myself and...I can't remember who the other person was. Some other big star. Thankfully [Brett Ratner] chose me for the project. Of all the parts! I mean, talk about just like...Brendan Fraser was the other person! It was a very lengthy »
6 July 2015 10:00 AM, PDT | Digital Spy | See recent Digital Spy - Movie News news »
Nicolas Cage's close shave with the Man of Steel is well-documented, but did you know that Magic Mike and White Collar's Matt Bomer almost played Superman?
Speaking on the Happy Sad Confused podcast, Bomer revealed that he was cast as the iconic superhero back in the early '00s on a film to be directed by Brett Ratner from a Jj Abrams script.
Bomer recalled screen-testing in full costume with Amy Adams playing Lois Lane. Brendan Fraser and Paul Walker were the other finalists for the role at the time.
"Brett chose me for the project and then it all fell apart," Bomer said. "It was a very lengthy process to get the role, I think it was over the course of three months because I went in in a cattle call. It sort of evolved from there.
"It was a month of, 'Okay, looks like this is going to happen'. »
24 June 2015 4:38 AM, PDT | E! Online | See recent E! Online news »
Regrets? Channing Tatum has a few. Chief among them is agreeing to star in Paramount Pictures' G.I. Joe: The Rise of the Cobra, directed by Stephen Sommers and written by Stuart Beattie, David Elliot and Paul Lovett. The action movie, which was released in 2009, grossed $302.4 million worldwide and also starred Adewale Akinnuoye-Agbaje, Lee Byung-hun, Christopher Eccleston, Brendan Fraser, Joseph Gordon-Levitt, Sienna Miller, Rachel Nichols, Ray Park, Jonathan Pryce, Dennis Quaid, Said Taghmaoui, Arnold Vosloo and Marlon Wayans. "Look, I'll be honest. I f--king hate that movie. I hate that movie! I was pushed into doing that movie, from Coach Carter," Tatum said during an interview on Howard »
12 June 2015 2:00 AM, PDT | Moviefone | See recent Moviefone news »
Did you know that June 12 every year is Superman Day? We're not sure how this particular day came to be dedicated to the Man of Steel, especially since he seems omnipresent in our lives every day. A pop cultural mainstay since 1938, the Krypton-born hero never seems far away, especially in the movies.
Yet while it seems every boy has dreamed of putting on the red cape and flying, the character has been remarkably hard to cast in movies. For every Christopher Reeve, Brandon Routh or Henry Cavill who said yes, many more have said no. Here are 15 potential Kal-El's that never came to be.
"Yo, Lois!" After the success of "Rocky," it's no wonder that "Superman: The Movie" producers Alexander and Ilya Salkind considered Stallone to play the Last Son of Krypton. Reportedly, he was deemed too ethnic for the part, though other sources have said that Marlon Brando »
- Gary Susman
7 June 2015 1:00 AM, PDT | Digital Spy | See recent Digital Spy - Movie News news »
The Goonies celebrates its 30th birthday today, and even after all these years we still adore this '80s classic.
Rumours have been swirling for some time about a Goonies 2 (make it happen, Hollywood!) with all the original cast returning, so with this in mind we take a trip down memory lane to find out what the stars of the cult classic are doing now.
Sean Astin played the slightly dorky yet bright, braces-clad Mikey - who attempts to leads his fellow adventurers to One-Eyed Willy's hidden fortune upon his discovery of an old treasure map.
The 44-year-old actor has continued to enjoy movie success with his role as Samwise Gamgee in The Lord of the Rings trilogy.
Astin also played Lynn McGill in hit Fox TV series 24, provides the voice of Raphael in Nickelodeon's TV version of Teenage Mutant Ninja Turtles (2012), and recently appeared in Guillermo del Toro »
1 June 2015 11:27 AM, PDT | backstage.com | See recent Backstage news »
Texas' incentive program is in jeopardy; "Texas Rising"'s ratings fall; and San Antonio hosts the latest installment of ABC's "What Would you Do?" It's this week's Texas News Roundup. Texas Sees Its Incentive Plan Go SouthState incentive programs have come under intense scrutiny lately, which may be why a whopping $63 million has been cut from the Texas Moving Image Industry Program. Critics also took issue with the fact that the program included equal part incentives for film, TV, and gaming, even though all don't bring the same amount of revenue. The cuts, said film lobbyist Lawrence Collins, mean that "film and television in Texas will disappear." Texas Rising Sees Ratings FallHistory's 10-hour miniseries "Texas Rising," which chronicles the Texas Revolution, debuted to 4.1 million viewers in its first hour, but saw those numbers fall 17 percent by the second hour. Directed by Roland Joffé ("The Killing Fields"), "Texas Rising »
26 May 2015 3:39 PM, PDT | Variety - TV News | See recent Variety - TV News news »»
23 May 2015 9:15 PM, PDT | We Got This Covered | See recent We Got This Covered news »
The story of the Texas Revolution is certainly worth the scope of a five-night, 10-hour miniseries on the History Channel. However, Texas Rising, which debuts on Memorial Day, is a plodding, bloated chronicling of a potent time in American history. Its star-studded cast, with around two dozen main or featured performers, is impressive; however, the breadth of the ensemble, filled to the brim with great character actors, doesn't allow for much depth with many of the characters. The result is not just middling, but somewhat problematic, considering the flattened portrayals of the Mexican and Comanche armies, both trying to hold onto native territory.
One surefire sign of the mini-series' lackluster quality comes in the opening minute, as several paragraphs of text float onto the screen to explain the back-story of how "Texas is in flames." There is so much history compressed to the few paragraphs that it is a »
- Jordan Adler
21 May 2015 3:38 PM, PDT | ChannelGuideMag | See recent ChannelGuideMag news »
The enormity of the talent involved in History's exhilarating new historical drama, Texas Rising, was more than evident as Bill Paxton, Olivier Martinez, Ray Liotta, Jeffrey Dean Morgan and Roland Joffé walked into a hotel cottage in Pasadena earlier this year to talk to us about the 10-hour event series. It's truly the TV event of the year with an emotionally riveting story and a cast list that extends beyond the aforementioned, which includes Brendan Fraser, Thomas Jane, Christopher McDonald, Jeremy Davies, Chad Michael Murray, Max Thieriot, Robert Knepper, Rhys Coiro, Crispin Glover, Jeff Fahey, Rob Morrow, Cynthia Addai-Robinson, Trevor … Continue reading →
The post Texas Rising on History is the TV event of the year, we talk with Bill Paxton, Ray Liotta & more appeared first on Channel Guide Magazine. »
- Barb Oates
21 May 2015 10:00 AM, PDT | We Got This Covered | See recent We Got This Covered news »
On the eve of Warner Bros. unleashing his disaster epic San Andreas, director Brad Peyton is fielding questions on all sorts of topics. So, it's only natural that when we sat down with him, the opportunity arose to ask Peyton about his other collaboration with San Andreas star Dwayne Johnson – 2012's Journey 2: The Mysterious Island. That pic, a sequel to 2008 Brendan Fraser starrer Journey to the Center of the Earth, seemed to cement Johnson as the franchise's new leading man while also laying the groundwork for Journey 3 and even Journey 4.
According to Peyton, it's still the plan to move ahead with two Johnson-led Journey sequels, and despite the lack of news about the projects, both films are very much in the works. The director revealed that Journey 3 (thought to take inspiration from Jules Verne's From the Earth to the Moon) has a finished script, but the fourth installment does not. »
- Isaac Feldberg
21 May 2015 7:24 AM, PDT | We Got This Covered | See recent We Got This Covered news »
The Human Centipede III (Final Sequence) is an empty, self-gratifying, wannabe exploitation flick that's crafted by a monkey who started by flinging poo at a wall with artistic intent – yes, The Human Centipede (First Sequence) has value – yet has now devolved into a smut-peddling attention whore who keeps flinging poo just to stay relevant. I wish I could stop my review of Tom Six's worst movie to date right there, but I cannot – because that would be doing all of you a disservice (and because I have a minimum wordcount requirement). Six's franchise has turned from a cheeky attempt to push unimaginable boundaries into a "for shocks only" nightmare that prays college film students will dare one another to sit through one last ass-to-mouth ensemble, cringing with every life-giving passage of waste. Unfortunately, Six's third film is a dare with no winners, whether or not you »
- Matt Donato
21 May 2015 7:15 AM, PDT | Variety - TV News | See recent Variety - TV News news »»
17 May 2015 8:21 PM, PDT | Alt Film Guide | See recent Alt Film Guide news »
Constance Cummings: Actress in minor Hollywood movies became major British stage star Constance Cummings: Actress went from Harold Lloyd and Frank Capra to Noël Coward and Eugene O'Neill Born on May 15, 1910, actress Constance Cummings, whose career spanned about six decades on stage, in films, and on television in both the U.S. and the U.K., would have turned 105 this year. Unlike other Broadway imports such as Ann Harding, Katharine Hepburn, and Claudette Colbert, the pretty, elegant Cummings – who could have been turned into a less edgy Constance Bennett had she landed at Rko or Paramount instead of Columbia – never became a Hollywood star. In fact, her most acclaimed work, whether in films or – more frequently – on stage, was almost invariably found in British productions. That's most likely why the name Constance Cummings – despite the DVD availability of several of her best-received stage performances – is all but forgotten. »
- Andre Soares
13 May 2015 6:24 PM, PDT | Monsters and Critics | See recent Monsters and Critics news »
TV Picks: "Texas Rising" is History's tent-pole event of 2015 set to premiere on Memorial Day.The network lucked out in securing a two-time Academy Award nominated director and an all-star cast. This was a massive undertaking that was filmed in the blistering desert of Durango, Mexico, in wide format CinemaScope. Quite simply, "Texas Rising" is a high quality, compelling historical drama that you must not miss.Two-time Oscar-nominated director Roland Joffé directs "Texas Rising" with an all-star cast including: Bill Paxton, Brendan Fraser, Ray Liotta, Jeffrey Dean Morgan, Olivier Martinez, Thomas Jane, Christopher McDonald, Jeremy Davies, Chad Michael Murray, Max […] »
- April Neale
1-20 of 39 items from 2015 « Prev | Next »
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The Bergs' 'Lone Survivor' Dominates the Box Office
Plus: Stars power 'August: Osage County' to Top 10 finish
Plus: Stars power 'August: Osage County' to Top 10 finish
Plus: 2013 by the numbers
The 'Iron Man' director on learning from Martin Scorsese's 'The Wolf of Wall Street' and his return to indie filmmaking
Plus: Justin Bieber flops with 'Believe'
'Our goal was to make a movie that could be part of that pantheon," the director says
Plus: 'Her' Shows Promise in Limited Release
The 42-year-old star on green-screen acting and channeling the Coen Brothers' humor for 'Fargo,' his American TV debut
Plus: It's a cruel Yule for 'Tyler Perry's A Madea Christmas'
Plus: 'Inside Llewyn Davis' strikes early sparks
Plus: 'Book Thief' and 'Philomena' break out of the art-house
Only nine percent of 2012's top-grossing films were directed by women. Inside Hollywood's tremendous imbalance
The response to 'Blue Is the Warmest Color' proves there's still confusion about what the film rating actually means
Plus: 'Frozen' ices all competition in limited release
'I miss SNL so much,' says the veteran funnyman. 'But the character in this movie is the closest to who I am in real life'
Plus: Bruce Dern seeks jackpot in 'Nebraska'
Plus: Nazis outrace Lance Armstrong at the art house
Plus: 'Dallas Buyers Club' opens strong in limited release
The technology behind our unmanned spyplanes and bombers will soon help even microbudget filmmakers capture awesome overhead shots. It could also make...
Plus: '12 Years a Slave' climbs the chart
Have scholars found the formula that predicts movie hits?
Plus: Tough luck for Sly, Arnold, and Benedict
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Hot answers tagged exchange-2010
On the phone, go into the email app Push the menu soft key. Select "settings". Select your email address. DO NOT tap "General preferences", tap your actual email address. Scroll to the bottom and uncheck Sync SMS OR: Go to Settings Select "Microsof Exchange ActiveSync" in Accounts group Select the "Settings" under Common settings group Select your ...
Solved. The vast majority of this is PowerShell script. (Start > Powershell Modules) First of all you need to set up the web proxy: (to be honest, I skipped this bit as the iPad in question will never leave the building and an external URL isn't required) To check settings: Get-ExchangeServer |fl To set setting: Set-ExchangeServer -Identity "MAIL01" ...
In 2013: Click on "VIEW", Choose "Change View" and choose "list" On the top left corner of the data, right click on the icon that looks like a sheet of paper. Choose "View Settings" Sellect "Columns..." Then add the colums you wish to view in your list of data. Change the dropdown under "Select available columns from:" to "All Appointment fields" Add the ...
You can change her alias, just make sure you keep the old ones so old mail is forwarded to the new one. Even if you were to mess up the mailbox won't be deleted so don't have any concerns about that. IF she does want to change her account name, you can simply create an email alias that points to her user account, and all messages will simply goto her 'new' ...
Outlook shows certificate security warning in local LAN although certificate is only associated to IIS
Your certificate is for webmail.example.org. If you're connecting to your Exchange server via server.domain, then the name will not match the common name in the certificate, thus the error. You either need a certificate that includes both names or you always have to use the external name (even when on the LAN). To make sure your clients use the external ...
Automate printing of more than 10,000 emails and their attachments, including the contents of ZIP files
MsgExtract can batch print email messages from different email sources and also convert email formats. It can batch print the emails and its attachments in chronological order. We have added in the latest build the ability to decompress and print zip attachments as per your requirement. It can save Outlook email as EML files It can save ...
Permissions for mailboxes are set at two different levels. You can define permissions at the database level and at the mailbox level. The mailboxes will inherit access right permissions from the database so I'd recommend you start there. The powershell code to see who has rights and what those rights are at the database level is: $Database = "your ...
What do you mean "set the sizes"? You can lower the size limits, and what happens is people can't send/receive email anymore (depending which limit you change), but the sizes won't change. If you want to shrink them, you need to delete content from them.
Through some digging and a bit of luck, I've found a solution to this problem. Shut down Mail.app Edit /Users/<username>/Library/Mail/V2/MailData/Accounts.plist in your favorite editor. Search for "EWSAccount" in the file, and you will see an XML structure similar to the following that contains the information for your particular setup, including the ...
In Outlook 2010 or Outlook 2007 you can change the calendar view to list, Then add columns that will show different fields, To do, once in the list view, go to View settings, in advanced view settings select columns, There a number of field types to chose from, find the one that has "Created", "modified" and you might also want to find "changed by", These ...
Yes, you need a LAN. You also need Active Directory, multiple Windows servers, licensing for Windows, user CALs, Exchange, Exchange CALs (client access licenses). It's a huge job to implement. If you could get LAN and internet access, outsource your email to Google.
You can bcc. You have to add users as Resources. This works with Outlook 2013 also.
Perhaps you are looking for the Exchange Server property of Maintain per-user read and unread information for this folder described by Microsoft as : When you select this setting for a public folder, the items in the folder change from the Unread state to the Read state for each user when the items are viewed by the user. However, the state ...
you can sync the AD user to office 365 using below link http://technet.microsoft.com/en-us/library/jj710171.aspx
This is for using forms authentication version of OWA 2010... On the Exchange server go to: C:\Program Files\microsoft\exchange\ClientAccess\Owa\auth Modify login.aspx - replacing the string autocomplete="off" with autocomplete="on" Now Internet Explorer will offer to remember the password to the site.
What about using Mac OS X Mail.app for getting at the Mails? That should be more light-weight than Outlook. As for Growl, there is a GrowlMail thingy...
This is really a server fault question because this is quite possible using Exchanges publish to html/ical feature. BUT, your admin has to enable cause I'm pretty sure it is off by default. If it IS enabled, basically the two of you will publish and sync a copy of your calendar to a third source, like Google Calendars.
This is a known issue for Outlook 2007 (and 2003), but not 2010. If it is Outlook 2007, then Outlook 2007 SP2 + the Hotfix available in MS KB2276479 should take care of it. Under Issues that this hotfix package fixes: Consider the following scenario: Your mailbox is moved to Microsoft Exchange Server 2010. In Office Outlook 2007, you ...
It seems at this point that Exchange is choking on the second HTTPS binding. It also seems you can only have one SSL port configured in IIS, and thus, only one SSL certificate. If you have multiple URLs that resolve to your mail server, and want to avoid certificate errors as a result of having the wrong CN on the certificate, you need to obtain an Exchange ...
I am sure you know the work around by now. CTRL - Click the documents you want to save and right click on one of them and choose Save As... This of course isn't a fix by any means, but it is the best workaround that I have seen since this problem started.
The very first feature I would turn on is the IP Blacklist provider (in your organization config under Edge (or in some cases Hub) transport settings in the console. You can set it up for a few different providers like spamhaus.org, etc.
Yes. This is possible. Install the Exchange Management Tools. Edit: Vista, 7, or 2008 only. Here's a technet link: http://technet.microsoft.com/en-us/library/bb232090.aspx
On the ribbon under file (Tools menu), Click Account Settings. Select the Outlook Mobile Service account that you want to remove Then click Remove. To confirm the removal of the account Click Yes
This link is an online users guide from microsoft. IMHO it does a very good job at providing an overview of the service, how it works and its offerings.
The email addresses are saved in an NK2 file which means you can use a batch file to remove the NK2 file. This can be added to either the logon script or logoff script (personally I'd add it to the logon script). This will then delete the NK2 file and no emails will be cached on that PC anymore. Here is a little batch file I mocked up (just in case you or ...
I have got these problems before, although I'm not quite sure about the exact error message. In my case I was only able to fix it by a complete removal and reinstallation of Outlook. When you say you re-created the profile, did you completely remove the account from Outlook? Did the error came back before importing the old emails? If you can answer both ...
Answer below: See the "Add a recipient's digital ID to your Contacts" heading [1] here. The sending issue sounds like your user doesn't have an up-to-date contact for the external user (including public key for the external user), so they can't encrypt a message to them. If they were an internal user, you might pick it up fro the GAL, but external users ...
I don't think there's a way to make Outlook run rules other than upon receipt or sending. May be possible with VBA, but I've never done Outlook automation so I can't help you there. However, you could make a rule to move the alerts to a separate folder upon arrival, then set the auto-archive option on that folder to remove when older than one day. This ...
I would think that the best way to achieve this is to create a LIST (distribution list). I don't believe that the list is expanded but instead appears as a single name. The Distribution List can unfortunately still be expanded by recipients.
At present, tasks will require a full Outlook client, unless another 1st or 3rd party app comes out that specifically addresses tasks the Mail and Calender clients in Windows 8 were not meant to replace the full functionality of Outlook in an Exchange environment as far as I am aware Outlook 2010 and 2013 both work without a problem in Windows 8 (so far :) ...
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Lane's story continues as she arrives in Edoras. Lane knew what it was to fight for the honor of her country, but she has never fought to help save innocent lives. And a closeness has grown between Legolas and Lane, but will their friendship survive it?