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The first student winners of the PowerBridgeNY awards have been announced by New York Governor Andrew M. Cuomo. The recently established Proof-of-Concept Center aids clean energy ideas move from the laboratory to commercial product. These awards continue to support the development of New York's cleantech economy to create jobs and businesses focused on emerging clean-energy technologies.
"New York is taking a leading role in supporting the development of cleantech products that are environmentally friendly, reduce energy use and increase reliability of the State's energy systems," said Governor Cuomo. "When the best and brightest cleantech researchers in New York State have the opportunity to collaborate with smart, experienced experts in the private sector, the result can be a powerful force for economic development resulting in a cleaner, greener, more sustainable state for future generations."
PowerBridgeNY was created by Columbia University and New York University Polytechnic School of Engineering, leading a consortium of public research institutions throughout the State, and is partially funded by the New York State Energy Research and Development Authority (NYSERDA). The winners, who were awarded up to $150,000, are working on products with the potential to reduce wastewater treatment costs, increase energy efficiency of solar panels, reduce electricity outages, decrease the cost of fuel cells, absorb carbon dioxide.
"The funding announced today will help these scientists, researchers and entrepreneurs move their innovative technology closer to market-readiness as they tackle technical clean-energy issues," said John B. Rhodes, President and CEO, NYSERDA. "Thanks to Governor Cuomo's support, the proof-of-concept centers are advancing cleantech innovation in New York State, growing new companies and commercializing the next generation of products that will help reduce the State's energy use."
Businesses were judged on the products' technical potential, the potential appeal to investors and how the scientists could benefit by taking part in this program. Continue reading


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ROOSTERGNN — Virtual
ROOSTERGNN, the future of journalism. The Global Journalism Internships, including registration and completing the Internship, are free of charge, and can be completed from any location in the world. …
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Ritzberg Realty International LLC — Virtual
Ritzberg Realty International LLC is looking for a marketing specialist ASAP!
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Looking for an Executive Administrative Assistant at Ritzberg Realty International LLC, ASAP, my business is growing and it's just me doing all aspects of the business. Would like someone who doesn't …
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Currently, looking for a intern to help write and produce content for a new website that is being launched in November. The website is done in an online magazine format including both written and vide…
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Progressive Turnout Project (turnoutpac.org) is a new federal PAC that launched in August, 2015. We are looking for creative, motivated, and hard-working people interested in getting involved in feder…
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Job Title: data processing-editing Job Location: South San Francisco, Ca Job Duration: 5 months plus Duties: Light editing to ensure correct template & text formatting / correct punctuation are consi…
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Irene Tyndale Events is a boutique planning and event styling company created specifically with you in mind. Whether you desire a classically elegant event or something more contemporary, we want to h…
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Select Local Merchants
Warehouse Tire StopRead MoreWarehouse Tire Stop knows finding a body shop you trust can be difficult, but they're more than happy to earn it in Waterford. Make your vehicle a little more attractive with some great car accessories from Warehouse Tire Stop, such as seat covers or floor mats. Don't let your vehicle's tires wear down. Have them changed or rotated here. Keep your ride looking as good as new with the help of the professional staff at Warehouse Tire Stop. Looking for great auto care and service you can rely on? Head over to Warehouse Tire Stop today.4459 Pontiac Lake RdWaterford, MI US
Tuffy Auto Service CentersRead MoreDon't hesitate to fix your car's wear and tear by bringing it into the body shop at Tuffy Auto Service Centers in Waterford. If you're ready to upgrade your vehicle from battered to beautiful, bring it in to the auto specialists at Tuffy Auto Service Centers. Tuffy Auto Service Centers' automotive shop is ready for your business today in Waterford with their convenient scheduling and right pricing for you and your car.5901 Highland RdWaterford, MI US
Al's Quick LubeRead MoreTake pride in your car's appearance by using the excellent staff at Al's Quick Lube's body shop in Waterford. Al's Quick Lube provides windshield replacement to help out impacted cars. A missing headlight or taillight is a small problem, which is why you should have Al's Quick Lube take care of that right away before any possible tickets. When the time for an oil change rolls around, this bar will have it done in no time. Bar knows that a multi-point vehicle inspection is perfect for preventing any car incidents that leave you stranded and in need of service. You'd be wise to take advantage of one today. You don't want to be stuck without A/C when the warm weather hits. Fix your A/C in a jiffy with some of the professional services here. We all know that accidents happen. When they do, the staff at Al's Quick Lube is here to help your car look as good as new. You definitely won't want to wait to get your car serviced by the experts at Al's Quick Lube's one-of-a-kind body shop in Waterford.5498 Dixie HwyWaterford, MI US
Brian's Small Engine RepairRead MoreGreat parts and quality body care can greatly increase the longevity of your vehicle. Keep your ride running like new for many miles to come with top notch care from Brian's Small Engine Repair in Ortonville. An oil change by Brian's Small Engine Repair will prevent your engine from making any obnoxious sputtering noises. Treat yourself to a tire change and rotation from Brian's Small Engine Repair and hit the streets feeling safe and balanced. Want to get your car completely re-imagined? You'll be happy to know Brian's Small Engine Repair offers scratch and dent repair as well. No matter your yard's needs, Brian's Small Engine Repair can promise you a first-rate landscaping. So stop in at Brian's Small Engine Repair, where you can expect quality service on vehicle repairs big and small. If you're looking to ensure your car's repairs don't stall your life, come to a reliable auto shop at Brian's Small Engine Repair so that you can be in and out without delay.1800 Oakfield StOrtonville, MI US
Transmission AuthorityRead MoreWhether your looking to customize or repair your ride, choosing the right body shop can make all the difference. Make the right choice with the auto experts at Transmission Authority in Waterford. Make your friends think you got a new car when you get rid of those dents and scratches using Transmission Authority's repair service. Rest assured, you'll find the affordable and perfect oil change at Transmission Authority's shop. For those in need of a great fluid replacement for their transmission, Transmission Authority recommends you stop by anytime. When it comes to the quality of your tires, Transmission Authority offers some great services like tire rotations and changes. For affordable vehicle repairs you can count on, be sure to choose Transmission Authority. When you rely on the professional team at Transmission Authority in Waterford, you'll be amazed at the difference of service quality and their fantastic prices.6900 Cooley Lake RdWaterford, MI US
Queen of Car Loans at Lunghamer ChevroletRead MoreNo matter the make, color, or year, Queen of Car Loans at Lunghamer Chevrolet's A+ car dealership will certainly have the car you need in Waterford. Among other services, Queen of Car Loans at Lunghamer Chevrolet can handle any of your car's scratches and dents, too. When the roads are slick with snow, you'll want to make sure your regular tires are changed for your snow ones. Queen of Car Loans at Lunghamer Chevrolet is happy to help you out! Ensure your vehicle's system get the maintenance it needs with a quality oil change. So when it comes to purchasing a new whip, you can count on Queen of Car Loans at Lunghamer Chevrolet to help you make the best choice for your personal needs. From tune-ups to total body work, you can always find great service for your vehicle at Queen of Car Loans at Lunghamer Chevrolet. Does your car need a check-up? Bring it in to the experts at Queen of Car Loans at Lunghamer Chevrolet today.475 Summit DrWaterford, MI US


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Tom Dixon has a vast commitment to design creativity and a mission to redefine how products are made and sold. The Tom Dixon lighting and furniture collections reflect all of his cutting-edge design and manufacturing innovations, from the product's shape and form to the raw materials and production processes used.
The Pressed Glass Pendant - Bowl is available with the following:
- Designed by Tom Dixon
- Material: Metal
- Shade Material: Glass
- Round Black ceiling canopy
- 98 inch Clear cable with tensile wire support
- UL Listed
- Made In India
- One 60 Watt (580 Lumens) 120 Volt E26 Medium Base Incandescent Lamp(s) (Not Included)
Compare Brightness:
LumensThe amount of light that comes from a bulb, which has commonly been measured in watts. The more lumens, the brighter the bulb.
WattageA measurement of the power delivered to a component of an electric circuit (allowing a one-ampere current to flow through the component under the pressure of 1 volt.)
Bulb ShapeBulb shapes are denoted with a letter, which describes the shape, and a number, which indicates the size. The number indicates the diameter of the light bulb at its widest part in eighths of an inch.
BaseThe part of the bulb that connects to the fixture and its power supply. Bulb bases are denoted with the letter E, and a number which indicates the diameter of the bulb base at its widest part in millimeters.
VoltageIndicates how much voltage a bulb can accept via the fixture it's installed in.
Light Color TemperatureThe relative color from a light source, measured on the Kelvin temperature scale. Warm light is lower in color temperature (2700-3000 K) and cool, blue light is higher (5000 K).
Average Rated LifeThe average amount time that a bulb is expected to last.
CRICRI = color rendering index. This number, which can go from 0 to 100, measures the ability of a light or bulb accurately renders colors. The higher the number, the better, with most quality bulbs these days measuring at least in the 80s.
- Cable: Length 98"
- Canopy: Diameter 4.9"
- Maximum Hanging: Length Adjustable To 101.9"
- Shade: Height 3.9", Diameter 7.7"
Need help with some of our terminology? Check out Lumens' Lighting & Design Glossary.
Related Searches and Products
The Tom Dixon Plane Triangle Pendant is a humble yet glamorous statement of geometric purity, featuring a thin triangle of brass-plated steel around a vanity-style glass diffuser. The metal pyramid clasps the glass sphere in the exact center, appearing two-dimensional ...
Soft in shape, texture and light, the Tom Dixon Felt Shade Pendant uses the technique of fabric forming to create its uniquely tactile shade. Grey on the exterior and white inside, the shade is created by heat pressing a double ...
Before it's blown, when glass is pulled out of a furnace it appears as a thick, molten module at the end of a blow pipe. The Tom Dixon Glass Bead Pendant replicates this form with a dense drop of raw ...
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When: Wed., Aug. 7, 8 p.m. 2013
225 Ryman St. (Missoula)
Reggae band John Brown's Body—named after a song about an abolitionist—brings its brand of "future roots" music to Stage 112 tonight at 8 PM. 112 Pattee St. $18/$15 in advance at stageonetwelve.com.
Select a star to rate.
© 2015 Missoula News


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Southampton PA (PRWEB) August 31, 2013
Commercial and residential customers alike are seeking superior conservation solutions that perform more effectively than conventional ideas but prove hard to find and are often misunderstood. Resource conservation has become an important issue word wide and multiple advanced technologies are now available that will make a serious difference. According to Scott Milne of National Energy Technologies, "The product and technology already exist that will make a true difference but it will require a shift in conventional thinking". Because these highly effective products are only available through small patent holders, this new site promises to make it easy to find and learn about the latest conservation strategies. The site features products that will save fuel, water, and energy. They purify air, laundry, clear allergens and kill bacteria, as well as provide efficient heat.
The site was greatly motivated by the owners desire to share with the millions of families afflicted by allergies and secondhand smoke that there is a better way, a much better way. Like most families my siblings and mother are like many, suffering and using additional air conditioning to attempt to clear the air. What they did not understand and what most people don't know is that advanced negative ionization does a far superior job removing even the smallest of particles and allergens from the environment with a fraction of the energy used. This product line will also use concentrated oxygen (
|Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved


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where to buy free product coupons online?
Search related deals
Search most popular deals similar to this one
Views: 139 Replies: 2
Ok, so I know eBay has free product coupons for sale. Does anyone know of any websites where I can purchase a free product coupon for cheap.
For example, Free Tide up to 32 loads, max $8 for only $1.50 per coupon?
If you don't want to type it in this post PLEASE pm me!!!


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Blue Man Group
Dare to Live in Full Color
74 Warrenton Street, Boston, MA 02116
73 people saved this
Blue Man Group's critically-acclaimed show has been called "visually stunning," "wildly inventive," and "hysterically funny." Although it is impossible to describe, people of all ages agree that Blue Man Group's show is an intensely exciting and wildly outrageous experience that leaves the entire audience in a blissful, euphoric state. With no spoken language, Blue Man Group is perfect for people of all ages, languages, and cultures. This unique theatrical experience is a form of entertainment like nothing else!
Of Note:
- Amenities: Accessible Facilities
HubWeek Festival Blends Art, Science & Technology
Massachusetts has an illustrious tradition of ideas, industry and innovation, plus an equally renowned creative...
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Cocoon room with private bathroom!United States, California, Santa Monica
About this listing
We offer our guests to have their own room with private bathroom in our home. We wanted to offer a budget accessible room to stay in LA a few blocks from the beach yet in a unique maritime inspired designer house! Grab a beach towel for a day of sunbathing on the famous Santa Monica beaches, take a walk along the Ocean to visit the neighboring Venice Beach, indulge in the best bars, cafes, restaurants in town by walking 15min to Main street! Drive on the road 66, the PCH, the 405 or I10 closeby!
Read the rules before booking
Towels, bed sheets, soap, and toilet paper
Central heating or a heater in the listing
Space where guests can cook their own meals
Towels, bed sheets, soap, and toilet paper
Central heating or a heater in the listing
In the building, free or for a fee
In the building, free or for a fee
Continuous access in the listing
Breakfast is provided.
The listing can accommodate a gathering of 25 or more attendees
Easy access to the building and listing for guests in wheelchairs
Private or Shared
Free, in the building or nearby
The Space
Cute private room in our house with private bathroom, TV with Netflix, comfy queen size bed, 2 armchairs, Nespresso machine, kettle, private fridge, a beach bike and WiFi ! The room has a large window to offer lots of natural light, a big closet for your luggage and clothes and we offer free access to our laundry room during specific hours. It takes about 20min to walk to the beach and less to reach main street with the cafes, bars, restaurants and nightlife...Easy access by bus from LAX airport
Enjoy Los Angeles' best beaches in this safe and green area and be 20" walk to the Ocean, the third street Promenade, the Santa monica Pier, the Whole Food Venice, 15" walk to Main street, 10" walk to Santa Monica College and 30" walk to the Penmar Golf, the Gold's Gym Venice and trendy Abbott Kinney!
Conveniently situated by the I-10 highway, you can quickly get to the Walt Disney and Sony studios, go party in West Hollywood or spend some time on the walk of fame in Hollywood and relax by the beach after that frenzy...A 5min drive and you'll be cruising on the famous Pacific Coast Highway (PCH) on your way to Malibu!
You can enjoy breakfast around the corner at the Novel Cafe or walk to main street and experience Dogtown caffe or the Urth Cafe, both great places as well!
Santa Monica college is a throw stone away and so is the good nightlife on main street in Santa Monica!
Landing at LAX and on a budget? Bus 3 gets you here for 1$ with minimum walk!
Guest Access
Guests access a completely private space immediately on the right when they get in. It's a small private room inside a townhouse and there's a common hallway to get in.
The laundry room is in the house and is shared with other guests
Other rooms are off limit, they are other listings
Interaction with Guests
We offer all our guests complete privacy with the possibility to meet us!
The Neighborhood
Green, safe and quiet! Within walking distance to the beach, great breakfasts, juices and lunches around the corner at novel cafe. Super easy access to I10 for downtown LA, studios, Pasadena and the PCH to get to Pacific palisades, Malibu...
Getting Around
LA is bad with public transport but we are close by the little it has to offer!
Super easy access from LAX! Bus 3 drops you around the corner and costs 1$ from the airport and by car it's almost a straight drive on Lincoln blvd...
Other Things to Note
We welcome you with a complimentary bottle of Californian wine, snacks, water, coffee and teas!
- Care for our home like your own
- We only allow extra guest for casual times not for parties
- Lock the front door when you leave, it's not automatic (only the upper bolt)
- Please be considerate if you come back late and/or after 10pm
- Washer and dryer use starts at 1.30pm and stops at 10pm
- There is no smoking area in the building, you have to go to the sidewalk (it's by Santa Monica law)
- Trash are in the back alley, on your left when you exit the building.
- The area up the stairs is private to other guests
- No pets allowed
182 Reviews
I will certainly recommend this place and if I come back, I will try to stay here again.
Full equipment, easy parking on street, good location (not so near to the beach, but still great).
Ferhat was a great host; very responsive to my questions on email and very considerate to let me stay while he was away for the weekend.
Very beautiful place, and cozy, very clean,it s close to the main road and beach, just 10mins jogging,u will see the beach!
Beautiful room, clean and comfortable, with private bathroom and coffe/tea maker, beach towel and even beach seat.
Los Angeles, Santa Monica specifically is a beautiful place. This space complimented the area so well. We arrived at night on a later flight and we're very grateful for the manual and all of the information we were given before hand to check in. The space was clean and we enjoyed our wine and chips! It is just as depicted in pictures.
We did not meet Ferhat and casually ran into a few other Air BnB'ers who were all very nice.
This spot is about a $4.00 Uber ride from the Santa Monica Pier and closer to shopping at Santa Monica Place. We never paid more than $20.00 to uber to Hollywood, Burbank, etc.
There is plenty of delicious food stops the next block up -- including a Starbucks which is the perfect way to start every morning and a Walgreens for any needs you may have.
This was a wonderful space and will definitely be looked at when returning to Santa Monica.
Great Host! I had an amazing time and the room was perfect for what I needed. Close to the beach, shops, bars etc.
Very well thought out room in a great location. Quiet neighborhood, easy parking but walking distance to the beach and the pier. Clean and looks just like the photos. The kitchenette is very useful with all the basic appliances. The only problem with the room was that when the tumble dryer in the hallway has been on the room gets extremely hot and humid even if you close the vent to the room. Still a very good airbnb and make sure you eat at the restaurant on the corner called Bowl Kitchen - excellent fresh Vietnamese food.
Ferhat à été super réactif quant aux différentes questions que l'on a pu avoir avant et pendant notre séjour.
La chambre était exactement comme indiquée sur l'annonce (propre et chaleureuse !!). Les petites attentions (comme la bouteille de vin ou encore le pot de Nutella) nous ont fait plaisir !! ☺
Le quartier est également vraiment sympa. Très calme et idéalement placé.
This is a great location if you want to be in Santa Monica. Easy to get around if you have a car and a 20 minute drive from LAX.
The room is great and the host provides accurate details to use every feature. The host is very responsive!
We would definitely stay here again!
The room was ready and treats were provided. Replies from the host were prompt and answered questions as needed. The area is safe , no need to worry about you car being left on the street. The refrigerator is a welcome addition, as is the washer & dryer option. As others have mentioned, this was our first Air BNB overnight experience, and it was a positive one. If we were to stay in Santa Monica again, we would stay here.
The room was lovely and comfortable, and had everything we needed for our stay.
This host has 709 reviews for other properties.View Other Reviews
About the Host, Kosmopolitan
For many Los Angeles is synonymous with Hollywood, beaches, good weather and GTA eventually! Yet there is a lot more, an outburst of arts that can be found everywhere and in multiple ways. It's that emulsion that resonated with my very hidden artistic nature and set me in motion from Europe, to find out what it was and how to make the best use of it. I am still journeying through that question, it's my Odyssey. What will be yours?


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|Publication number
|Publication type
|Application number
|Publication date
|Sep 6, 1988
|Filing date
|Oct 26, 1987
|Priority date
|Oct 15, 1985
|Fee status
|Also published as
|Publication number
|Eric A. Forssen
|Original Assignee
|Vestar, Inc.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (12), Non-Patent Citations (16), Referenced by (47), Classifications (25), Legal Events (7)
|External Links: USPTO, USPTO Assignment, Espacenet
This application is a continuation-in-part of copending U.S. patent application Ser. No. 787,535, filed Oct. 15, 1985, now abandoned, in the name of Eric A. Forssen and of common assignment with this application.
This invention relates to compositions consisting of phospholipid encapsulated anthracycline anti-neoplastic agents. In another aspect it relates to the use of such compositions to deliver chemotherapeutic agents to tumors in a body.
Daunorubicin (also known as daunomycin), doxorubicin (also known as Adriamycin), Aclacinomycin A and other cationic anthracycline anti-neoplastic agents are currently of great clinical interest for the treatment of tumors, including most leukemias and solid tumors. Structurally, these compounds consist of a hydrophobic tetracycline ring system coupled to an amino sugar through a glycoside linkage. These anthracycline agents associate with phosphate containing materials, and exhibit a high affinity with, for example, cardiolipin. These compounds have been shown to exhibit marked activity against a wide variety of neoplasms. However, the clinical use of these drugs in humans has been limited by the chronic toxic effect of the drugs on heart tissue. Children for example, are highly susceptible to doxorubicin-induced congestive heart failure. Mosijezuk, et al., Cancer, 44, p. 1582-1587 (1979). Long-term administration of such drugs leads to an increased risk of cardiomyopathy. Lefrak et al., Cancer, 32, p. 302-314 (1973).
Phospholipid bilayer membrane particles in the form of unilamellar vesicles known as liposomes have received increasing attention as possible carriers for anthracycline drugs. Certain formulations have been shown to increase antitumor activity, alter in vivo tissue distribution and decreas toxicity.
Difficulties have been encountered in producing encapsulated anthracyclines. In part this has been due to the surfactant or detergent-like effect these compounds exert on the phospholipid vesicle bilayer, causing leakage and creating vesicle instability. Another problem has been the aggregation of such vesicles during storage. In addition, the efficiency of entrapment of previous formulations of encapsulated anthracyclines has been low, and has been reported to be between 5 and 65%. Forssen and Tokes, Cancer Res. 43, p. 546-550 (1983); and Gabizon et al., Cancer Res. 43, p. 4730-4735 (1983); and Gabizon et al., Br. J. Cancer 51, p. 681-689 (1985). Thus it has not been possible to achieve large scale production of stable, encapsulated anthracyclines for therapeutic purposes.
Accordingly, it is an object of the present invention to provide improved formulations for encapsulating anthracycline anti-neoplastic agents in phospholipid bilayer membrane particles.
Another object of this invention is to provide a method fo using improved formulations of encapsulated anti-neoplastic agents to provide decreased cardiotoxicity and increased antitumor efficacy in humans.
The manner in which these and other objects are realized by the present invention will be apparent from the summary and detailed description set forth below.
Compositions comprising anthracycline anti-neoplastic agents encapsulated in phospholipid bilayer membrane particles consisting, in one embodiment, of anionic phospholipids such as distearoyl phosphatidylglycerol admixed with neutral phospholipids such as distearoyl phosphatidylcholine are described. In another embodiment of this invention the composition can also contain cholesterol or like-acting substances, but this is not essential to the practice of the invention. The particles are suspended in a low ionic strength aqueous phase such as an aqueous solution of a physiologically acceptable nonionic hydroxyl-containing compound, e.g., a monosaccharide such as dextrose or a polysaccharide such as lactose. This low ionic strength aqueous phase will be one having as low a content of extraneous anions, e.g., chloride ions from an anthracycline anti-neoplastic agent such as daunorubicin hydrochloride, as can practicably be achieved, e.g., an anion concentration of about 5 mMolar (millimolar) or less, and a pH preferably between about 6.0 and about 8.0.
A particularly preferred composition comprises daunorubicin, distearoyl phosphatidylglycerol and distearyol phosphatidylcholine in a molar ratio of these components of 1:1.5:7, respectively, suspended in an aqueous phase comprising a disaccharide such as lactose, preferably a 9-11% lactose solution containing 5 mM TRIS base (Tromethamine or 2-amino-2-hydroxymethyl-1,3-propanediol) at a pH of about 6.0 to 8.0.
These compositions may be administered in multiple doses to a human subject to treat tumors.
FIG. 1 illustrates the in vivo levels (biodistribution) of C-14 labeled daunorubicin, free and vesicle entrapped in the blood in mice at 1, 4, 24 and 48 hours.
FIG. 2 illustrates the in vivo levels (biodistribution) of C-14 labeled daunorubicin, free and vesicle entrapped in solid tumors in mice at 1, 4, 24 and 48 hours.
FIG. 3 illustrates the in vivo levels (biodistribution) of C-14 labeled daunorubicin, free and vesicle entrapped in heart tissue in mice at 1, 4, 24 and 48 hours.
FIG. 4 illustrates the in vivo hepatic levels (biodistribution) of C-14 labeled daunorubicin, free and vesicle entrapped in mice at 1, 4, 24 and 48 hours.
FIG. 5 depicts the rate of survival in mice bearing solid tumors treated on day 3 with a single dose of free or vesicle-entrapped daunorubicin.
FIG. 6 shows the effect on tumor volume of single doses of daunorubicin, free or vesicle-entrapped, administered to mice bearing solid tumors.
FIG. 7 illustrates the effect on tumor volume of multiple (20 mg/kg) doses of free or vesicle entrapped daunorubicin in mice bearing solid tumors.
FIG. 8 depicts the survival rate for mice bearing solid tumors and receiving multiple doses (20 mg/kg) of free or vesicle entrapped daunorubicin.
The vesicles for which the results illustrated in FIGS. 1-8, inclusive were obtained were those of Example I hereinbelow.
FIG. 9 illustrates the uptake of tritiated daunorubicin by whole blood, tumor tissue (P-1798 lymphosarcoma) and three other tissues in mice as determined for the daunorubicin-containing vesicles of Examples II, III and IV hereinbelow, for free daunorubicin and for daunorubicin simply admixed with distearoyl phosphatidylglycerol in a 1:1 mol ratio.
FIG. 10 indicates the therapeutic effects of the daunorubicin-containing vesicle formulations of Examples II and IV hereinbelow, compared to each other and to free daunorubicin, for a solid tumor in mice.
FIG. 11 illustrates the results of a study on the effect on tumor sizes of the daunorubicin-containing vesicle formulations of Examples II and IV hereinbelow.
FIG. 12 illustrates the in vivo levels (biodistribution) of tritiated daunorubicin, free and vesicle entrapped (Example III hereinbelow), in the blood, in solid tumors, in heart tissue and in the livers of mice over a 48 hour period.
As indicated above, according to this invention encapsulation and improved delivery of anthracycline anti-neoplastic agents useful in treating tumors in humans is achieved using compositions containing bilayer membrane particles, preferably in the form of small, unilamellar vesicles consisting of a mixture of anionic and neutral phospholipids, and a cationic anthracycline anti-neoplastic agent, suspended in a low-ionic strength aqueous phase in which a physiologically acceptable nonionic hydroxyl-containing compound is dissolved and which contains as low a content of extraneous anions as can practicably be achieved.
That anthracyclines exhibit a high affinity for the phospholipid cardiolipin appears to be of particular importance for mediating the biological activities of these drugs. Cardiolipin, however, is not a desirable constituent for phospholipid vesicles in spite of its high affinity for anthracyclines because when interacting with an anthracycline such as daunorubicin it forms micelles which destabilize the bilayer structure of encapsulating particles such as liposomes. Cardiolipin is also known to be highly antigenic in nature when incorporated in liposome membranes, and thus may cause an increased immunogenic response when injected into a body.
As noted above, one of the difficulties associated with the entrapment of anthracycline anti-neoplastic agents in phospholipid bilayer membrane particles is their amphiphilic nature, which can cause these drug molecules to attempt to partition nearly equally between aqueous and lipid media. This partitioning can, in turn, cause these drugs to easily leak from lipid membranes and can disrupt the membranes themselves, destroying the vesicles' bilayer structure. An advantage of using an anionic phospholipid such as distearoyl phosphatidylglycerol is that it has a negative charge which can be used to cancel the positive charge on the cationic anthracycline molecule. This permits the production of neutral vesicles which resist disruption and leakage. Furthermore, the use of a low-ionic strength aqueous phase to suspend the vesicles improves vesicle stability because it inhibits vesicle aggregation.
An additional advantage of using such negatively charged phospholipids is that the cancellation of the charge on the anthracycline molecule permits the formation of a water insoluble salt between the phospholipid and the anthracycline. This complex increases the affinity of the drug for the hydrophobic bilayer of the vesicle, and although I do not wish to be bound by any particular theory or mechanism advanced to explain the operation of this invention, I believe that the drug becomes entrapped in the vesicle membrane itself rather than simply being present within the vesicle's interior aqueous space. While an anthracycline such as daunorubicin will bind fairly strongly to a negative phospholipid such as distearoyl phosphatidylglycerol with a binding constant of approximately 105 M-1, its affinity for binding to DNA in a cell is much greater, on the order of 2�106 M-1. Thus, the drug will be able to be released from the distearoyl phosphatidylglycerol and to complex with DNA present in the target tumor cells.
The micellular particles of this invention are preferably in the form of small [less than about 60 nm (nanometers), and preferably about 45-55 nm in diameter] unilamellar phospholipid vesicles prepared by sonication as described by M. R. Mauk and R. C. Gamble, Anal. Bioc., 94, p. 302-307 (1979), or by microemulsification using the procedures described in Gamble copending U.S. patent application filed Jan. 31, 1985, Ser. No. 696,727, of common assignment with this application. Vesicles prepared in this fashion having the types and amounts of components taught by this invention exhibit a high efficiency of entrapment (greater than 90%) of the anthracycline anti-neoplastic agent, a good storage life (about 90% particles intact after two weeks), adequate targeting of the drug to tumor tissue and little or no tendency to aggregate. One advantage of the higher entrapment efficiency is that the step of separating free drug from entrapped drug after loading procedures may be eliminated, thus simplifying manufacture.
Adjustment of pH is an additional factor for maximum drug entrapment when practicing this invention, with the optimal pH range being from about 6.0 to 8.0. A suitable substance for adjusting pH is TRIS base (Tromethamine or 2-amino-2-hydroxymethyl-1,3-propanediol) since it can readily be buffered over a pH range of 7 to 9. Other bases such as sodium hydroxide or potassium hydroxide, amine bases such as N-methylglucamine, and the like, which will not contribute unwanted anions, can also be used.
It has been found in the present invention that by using anionic phospholipids such as distearoyl phosphatidylglycerol (sometimes referred to hereinafter as DSPG) with neutral phospholipids such as distearoyl phosphatidylcholine (sometimes referred to hereinafter as DSPC), the partitioning of an anthracycline anti-neoplastic agent such as daunorubicin (sometimes referred to hereinafter as DAU) into the lipid phase may be increased, leading to increased entrapment of the anthracycline anti-neoplastic agent in the micellular particle and more stable particles. The incorporation of cholesterol (sometimes referred to hereinafter as CHOL) ca further improve the stability of the particles encapsulating the anthracycline anti-neoplastic agent, and in all cases the stability of these compositions is further enhanced by suspending the particles in a low-ionic strength aqueous phase in which a physiologically acceptable anionic hydroxyl-containing compound is dissolved and which contains as low a content of extraneous anions as can practicably be achieved.
Among the anionic phospholipids which can be employed in practicing this invention are phosphatidylglycerols, phosphatidylserines, phosphatidylinositols and phosphatidic acids, such as distearoyl phosphatidylglycerol, dipalmitoyl phosphatidylglycerol, distearoyl phosphatidylserine, dioleoyl phosphatidylinositol, and the like. Neutral phospholipids which can be used together with an anionic phospholipid include phosphatidylcholines and phosphatidylethanolamines, such as distearoyl phosphatidylcholine, 1-palmitoyl-2-oleoyl phosphatidylcholine, dilinoleoyl phosphatidylethanolamine, and the like.
The mol ratio of anthracycline anti-neoplastic agent to total phospholipid [anionic plus neutral phospholipid(s)] in the compositions of this invention should preferably be no more than about 1:20, with mol ratios of about 1:10 or less being particularly preferred, although there is no upper limit, other than one imposed by the practical considerations one faces when working with injectable substances, on the total amount of phospholipids which can be used. The mol ratio of anthracycline anti-neoplastic agent to the anionic phospholipid(s) alone will be at least about 1:1.25, and preferably at least about 1:1.5. From about 1 to about 50 percent, and preferably from about 10 to about 20 percent, by weight, of the total weight of phospholipids present will preferably be anionic phospholipid(s), the balance being neutral phospholipid(s), but here too these amounts are not critical.
Compositions prepared in accordance with this invention having the aforementioned drug to anionic phospholipid mol ratios, particularly when prepared using an aqueous 9-11% lactose solution containing a small amount of base - typically 5 mM TRIS base - have been found to provide adequate targeting of the drug to tumor tissue (targeting efficiencies of about 90% or more have been observed) while, at the same time, limiting or eliminating the tendency of the phospholipid vesicles to aggregate. And, since neutral vesicles appear to be more effective for delivering anthracycline anti-neoplastic agents to tumors (see Mauk and Gamble, loc. cit.), the foregoing ratios of anthracycline anti-neoplastic agent to phospholipid components, which minimize the net negative charge of the vesicles while maintaining the physical integrity of the vesicles' structure by preserving the stability of the drug in the bilayer, are generally preferred when practicing this invention for this reason as well.
Cholesterol and like-acting substances, e.g., other sterols, when used, can be present in the compositions of this invention in mol ratios of cholesterol or the like to total phospholipid(s) ranging from about 1:1 to about 0:1, respectively, and in mol ratios of cholesterol or the like to anthracycline anti-neoplastic agent ranging from about 0:1 to about 20:1, respectively.
To prepare vesicles, the lipids and anthracycline anti-neoplastic agent, daunorubicin for example, to be used for vesicle preparation are weighed out in the desired ratios and are either dissolved in an organic solvent such as methanol or chloroform or kept until use as dry powders. If a solvent is used, it must be removed prior to the addition of the aqueous phase, by evaporation, for example under argon or nitrogen, or by application of a vacuum.
The aqueous phases preferred for formulation of anthracycline vesicles with high entrapment and maximum stability are low-ionic strength media which contain one or more physiologically acceptable nonionic hydroxyl-containing compounds and which also contain a low or minimal amount of extraneous anions. Extraneous anions include, for example, chloride ions from an anthracycline anti-neoplastic agent such as daunorubicin hydrochloride, and will be present in amounts as low as can practicably be achieved, e.g., an anion concentration of about 5 mM or less, such as can be achieved in sugar solutions in deionized distilled water. Sugars which can be used include monosaccharides such as dextrose, fructose and galactose and disaccharides such as lactose, sucrose, maltose and trehalose. An aqueous 9-11% lactose solution containing a small amount of base, e.g., 5 mM TRIS base, is particularly preferred. Such solutions minimize drug leakage from vesicles and decrease vesicle aggregation, and are well suited for parenteral use, for example human intravenous injection.
In order that those skilled in the art can more fully understand this invention, the following examples, which describe the preparation, characterization and in vivo chemotherapeutic application in animal models of vesicle formulations of this invention, are set forth. These examples are presented solely for purposes of illustration and are not intended to limit the present invention in any way.
Phospholipid vesicles were prepared using distearoyl phosphatidylglycerol, distearoyl phosphatidylcholine, cholesterol and daunorubicin in a molar ratio of DAU:DSPG:DSPC:CHOL of 1:4:5:6.
The lipids were obtained from Avanti Polar Lipids, (Birmingham, Alabama) and the daunorubicin was obtained from Sigma Chemical Co., (St. Louis, Missouri). These compounds were weighed out in the desired ratios and were dissolved in the organic solvent chloroform. The solvent was removed prior to addition of the aqueous phase by evaporation under nitrogen gas followed by vacuum. The non-ionic aqueous phase, consisting of 5% dextrose solution in water, pH adjusted to 7.4 with sodium hydroxide, was added to the lipid mixture and the solution was heated in a water bath at 60� to 70� C. for 1 to 3 minutes then vigorously agitated to form a suspension of the drug-lipid mix. This step was repeated until all the material had been suspended in the aqueous phase. This mixture was then sonicated using a needle probe sonicator (Sonics and Materials, Danbury, Conn.), at an output control setting of 1-2 (on a scale of 10). The sample was sonicated until clear, about 2-5 minutes for a 5 ml sample. During sonication the mixture was heated at 10� to 80� C. in a water bath. Following sonication, the sample was centrifuged to remove all particulate matter.
The vesicles containing daunorubicin, prepared as described above, were characterized for size (diameter) and entrapment efficiency following preparation. Vesicle sizing was performed using a Laser Particle Sizer Model 200 (Nicomp Instruments, Santa Barbara, Calif.) and was determined to be in the range of 45 to 55 nanometers in diameter.
The efficiency of association of daunorubicin within the vesicles was estimated using Sephadex G 50 gel-filtration to separate free from entrapped daunorubicin. Using the above formulations, 90-100% of the daunorubicin was found to be associated with the vesicles. Due to this high association, additional separation steps were unnecessary to remove free drug.
The daunorubicin vesicles prepared as described above were examined using HPLC and were found to be stable as indicated by the lack of chemical decomposition comparing freshly sonicated vesicles with those left at room temperature for two weeks. In addition, when a 2 ml sample of these vesicles were frozen in dry ice and later thawed at 65� C., the vesicles maintained their original size a determined by light scattering using the Laser Particle Sizer, and also retained all of the previously entrapped daunorubicin as determined by Sephadex gel filtration. Finally, incubation of Indium-III loaded daunorubicin vesicles in serum at 37� C. for 24 hours following the procedures described by Mauk and Gamble, loc. cit., for loading In-III in phospholipid vesicles, demonstrated no loss in entrapped In-III had occurred as determined by x-ray perturbed angular correlation ("PAC") (no decline in G22).
Biodistribution studies of C-14 labeled daunorubicin, both free and vesicle entrapped, were conducted using a daunorubicin dose of 5 mg/kg in CD2 F1 mice bearing intradermal P-1798 lymphosarcoma solid tumor. Time points were taken at 1, 4, 24 and 48 hours. The results are presented in FIGS. 1 through 4 showing that daunorubicin vesicles remain in the blood for longer periods of time than free drug and that in tumor tissue the level of vesicle encapsulated daunorubicin was significantly higher than free daunorubicin.
It appears that daunorubicin vesicles are not more toxic and are most likely less toxic than unencapsulated drug in animals bearing tumors as determined by survival in a small sample of mice using doses of 10, 20 and 30 mg/kg. In this limited study, toxicity induced deaths occurred only for the high dose unencapsulated daunorubicin (30 mg/kg), at a 100% rate. In contrast, no deaths occurred in mice receiving an equal dose of vesicle encapsulated daunorubicin.
CD2 F1 mice implanted with intradermal P-1798 solid lymphosarcoma received free and vesicle-encapsulated daunorubicin in a single dose injection of 20 mg/kg, and in multiple dosages of 5, 10 and 20 mg/kg.
In the first investigation, groups of 10 mice received free daunorubicin or daunorubicin-vesicles in 20 mg/kg single doses at three or four days following tumor implantation. Tumors were measured using calipers and the survival over time of treated and control mice was recorded. Controls consisted of injections of a 5% dextrose in water solution at 2 ml/20 gm doses.
Representative results of these investigations are shown in FIG. 5 for treatment commencing on day 3 after tumor implantation. Typically, with tumor metastasis, mice with tumors die within 14-17 days. Survival times for daunorubicin-vesicle treated mice increased in comparison to free drug. The median life span of mice injected with daunorubicin-vesicles was 21 days. All mice receiving free or vesicle entrapped daunorubicin demonstrated significant inhibition of tumor growth compared with untreated controls. Mice receiving vesicle entrapped daunorubicin had less tumor growth than those receiving free doses, as depicted in FIG. 6.
In a second study of chemotherapeutic effects of injections of daunorubicin-vesicles, groups of ten mice received multiple doses of 5, 10 and mg/kg. Treatments were initiated on day 4 and followed at weekly intervals (day 11, day 18) for a total of three doses. Body weight and tumor size were monitored during the study. As shown in FIG. 7, at 20 mg/kg significant inhibition of tumor growth occurred in daunorubicin-vesicle treated mice compared with those treated with free drug. Survival times were investigated in a group of 19 mice and as indicated in FIG. 8 following tumor implantation were significantly increased for daunorubicin-vesicle treated mice relative to free drug at doses of 20 mg/kg.
These results clearly demonstrate the usefulness and efficacy of the vesicle formulations of the present invention as improved vehicles for delivering anthracyclines to tumors in a body.
The procedure of Example IA above was repeated in every essential detail except for the materials used to prepare the anthracycline anti-neoplastic agent-containing phospholipid vesicles, i.e.:
in Example II radioactive labeled (tritiated) daunorubicin was used to prepare vesicles having the same DAU:DSPG:DSPC:CHOL molar ratio (1:4:5:6, respectively) as in Example IA (cholesterol was used);
in Example III the vesicles were prepared using tritiated daunorubicin with distearoyl phosphatidylglycerol and distearoyl phosphatidylcholine in a molar ratio of DAU:DSPG:DSPC=1:1.5:7, respectively (no cholesterol was used);
in Example IV the vesicles were prepared in a DAU(tritiated):DSPG:DSPC:CHOL molar ratio of 1:1.5:7:2, respectively (cholesterol was used);
a 9% lactose solution in deionized distilled water containing 5 mM TRIS base was used in each instance as the low ionic strength aqueous phase.
The uptake of tritiated daunorubicin by whole blood, tumor tissue (P-1798 lymphosarcoma) and thre other tissues in mice was then determined for the daunorubicin-containing vesicles of Examples II, III and IV, for free daunorubicin and for daunorubicin simply admixed with distearoyl phosphatidylglycerol in a 1:1 mol ratio. In all cases the administered dose of daunorubicin was 20 mg/kg (normalized to the hydrochloride form; equivalent to about 35.5 μM/kg). The results of these determinations are shown graphically in FIG. 9, in which the numbers below the legends "Dau:Ves." indicate the mol ratios of each component in the particular formulation [the first formulation listed under the legend "Dau:Ves." (1:1.5:7:0) is that of Example III, the second (1:1.5:7:2) is that of Example IV, the third is that of Example II].
As indicated in FIG. 9, merely combining daunorubicin with distearoyl phosphatidylglycerol produced no increase in tumor uptake. A vesicle formulation with a relatively high proportion of distearoyl phosphatidylglycerol (1:4:5:6; Example II) did increase tumor drug levels over those for free daunorubicin. However, two other formulations, either with (1:1.5:7:2; Example IV) or without cholesterol (1:1.5:7:0), which had lower mol proportions of distearoyl phosphatidylcholine produced even greater tumor drug levels.
The therapeutic effects of the daunorubicin-containing vesicle formulations of Examples II and IV, indicated in FIG. 10 as "Fmln-A" and "Fmln-B", respectively, were compared to each other and to free daunorubicin for a solid tumor in mice. The results shown in FIG. 10 indicate that the formulation with the lower targeting ability (Fmln-A) did little to improve median survival times relative to free daunorubicin at doses of 25 mg/kg or below. Only when tested at dose levels of 30 mg/kg and above did Fmln-A demonstrate improved efficacy. However, the formulation with improved targeting characteristics (Fmln-B) demonstrated improved therapeutic efficacy at all tested dose levels.
Tumor sizes were determined in a repeated study of Fmln-A and Fmln-B. The results of this study, shown in FIG. 11, demonstrated that the formulation which does target more effectively to tumor tissue (Fmln-B) has the direct effect of enhancing tumor growth suppression.
Biodistribution studies of tritiated daunorubicin, both free and vesicle entrapped (DAU:DSPG:DSPC mol ratio=1:1.5:7; Example III hereinabove) were conducted over a 48 hour period using a daunorubicin dose of 20 mg/kg in CD2 F1 mice bearing intradermal P-1798 lymphosarcoma solid tumor. The results of these studies are illustrated in FIG. 12, in which the error bars are for the standard error, n=5 for each data point.
Although this invention has been described with reference to particular applications, the principles involved are susceptible of other applications which will be apparent to those skilled in the art. The invention is, therefore, to be limited only as indicated by the scope of the claims appended hereto.
|Cited Patent
|Filing date
|Publication date
|Nov 8, 1979
|Jan 12, 1982
|California Institute Of Technology
|Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances
|Jun 13, 1980
|May 25, 1982
|Eli Lilly And Company
|Magnetically-localizable, biodegradable lipid microspheres
|Jun 22, 1981
|Oct 26, 1982
|Sandoz, Inc.
|Liposome drug delivery systems
|Aug 17, 1981
|Oct 25, 1983
|Hoffmann-La Roche Inc.
|Pharmaceutical preparations
|Dec 31, 1981
|Jan 24, 1984
|Imperial Chemical Industries Limited
|Pharmaceutical compositions
|Aug 17, 1982
|Jan 24, 1984
|The United States Of America As Represented By The Department Of Health And Human Services
|2'Halo derivatives of daunomycin, desmethoxy daunomycin, adriamycin and carminomycin
|Apr 14, 1982
|Mar 20, 1984
|Farmaitalia Carlo Erba S.P.A
|4'-Iododerivatives of anthracycline glycosides
|Aug 6, 1982
|Oct 2, 1984
|Sanraku-Ocean Co., Ltd.
|Anthracycline antibiotics
|Jan 29, 1985
|Oct 28, 1986
|Ciba-Geigy Corporation
|Spontaneous preparation of small unilamellar liposomes
|Title not available
|Title not available
|Sep 6, 1984
|Mar 14, 1985
|Health Research Inc
|Liposome delivery method for decreasing the toxicity of an antitumor drug
|Forssen and Tokes, Cancer Res., 43, pp. 546 550, (1983).
|Forssen and Tokes, Cancer Res., 43, pp. 546-550, (1983).
|Gabizon et al., Br. J. Cancer, 51, pp. 681 689, (1985).
|Gabizon et al., Br. J. Cancer, 51, pp. 681-689, (1985).
|Gabizon et al., Cancer Res., 42, 4734 4739, (1982).
|Gabizon et al., Cancer Res., 42, 4734-4739, (1982).
|Gabizon et al., Cancer Res., 43, pp. 4730 4735, (1983).
|Gabizon et al., Cancer Res., 43, pp. 4730-4735, (1983).
|Gregoriadis, "Liposome Technology", vol. 1, Preparation of Liposomes, (Boca Raton, Fla.: CRC Press Inc., 1984); Strauss, Freezing and Thawing of Liposome Suspensions", pp. 197-219.
|Gregoriadis, Liposome Technology , vol. 1, Preparation of Liposomes, (Boca Raton, Fla.: CRC Press Inc., 1984); Strauss, Freezing and Thawing of Liposome Suspensions , pp. 197 219.
|Lefrak, et al., Cancer, 32, pp. 302 314, (1973).
|Lefrak, et al., Cancer, 32, pp. 302-314, (1973).
|M. R. Mauk and R. C. Gamble, Anal. Bioc., 94, pp. 302 307, (1979).
|M. R. Mauk and R. C. Gamble, Anal. Bioc., 94, pp. 302-307, (1979).
|Mosijezuk, et al., Cancer, 44, pp. 1582 1587, (1979).
|Mosijezuk, et al., Cancer, 44, pp. 1582-1587, (1979).
|Citing Patent
|Filing date
|Publication date
|Aug 4, 1989
|Aug 7, 1990
|Vestar, Inc.
|Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
|Dec 12, 1988
|Dec 31, 1991
|The Liposome Company, Inc.
|Encapsulation of antineoplastic agents in liposomes
|Jan 15, 1991
|May 25, 1993
|Liposome Technology, Inc.
|Solid tumor treatment method and composition
|Jun 22, 1993
|Dec 27, 1994
|Daiichi Pharmaceutical Co., Ltd.
|Method of producing liposomal products from freeze or spray-dried preparations of liposomes
|Jun 2, 1992
|Jan 10, 1995
|The Liposome Company, Inc.
|Accumulations of amino acids and peptides into liposomes
|Jun 16, 1993
|Jun 6, 1995
|Depotech Corporation
|Heterovesicular liposomes
|Oct 22, 1984
|Jul 25, 1995
|Vestar, Inc.
|Method of targeting a specific location in a body
|May 14, 1993
|Oct 3, 1995
|Depotech Corporation
|Method for treating neurological disorders
|Jun 7, 1995
|Nov 19, 1996
|Depotech Corporation
|Method for treating neurological disorders
|Feb 13, 1995
|Nov 26, 1996
|Fundac ao E. J. Zerbini
|Microemulsions used as vehicles for carrying chemotherapeutic agents to neoplastic cells
|Aug 26, 1993
|Apr 1, 1997
|The Liposome Company, Inc.
|High drug:lipid formulations of liposomal antineoplastic agents
|Jun 6, 1995
|Sep 9, 1997
|Nexstar Pharmaceuticals, Inc.
|Inhibition of aggregation of drug containing particles
|Jun 6, 1995
|Mar 3, 1998
|Depotech Corporation
|Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
|Jun 5, 1995
|Apr 7, 1998
|The Liposome Company, Inc.
|Encapsulation of antineoplastic agents in liposomes
|May 25, 1995
|Apr 28, 1998
|The Liposome Company, Inc.
|Methods of treatment using high drug-lipid formulations of liposomal-antineoplastic agents
|Jun 6, 1995
|Sep 15, 1998
|Depotech Corporation
|Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride
|Jun 6, 1995
|Oct 6, 1998
|Nexstar Pharmaceuticals, Inc.
|Method of making liposomes with improved stability during drying
|Sep 25, 1997
|Mar 30, 1999
|Nexstar Pharmaceuticals, Inc.
|Vinca alkaloid vesicles with enhanced efficacy and tumor targeting properties
|Jul 14, 1995
|Aug 3, 1999
|Depotech Corporation
|Epidural administration of therapeutic compounds with sustained rate of release
|Sep 13, 1994
|Nov 30, 1999
|Skyepharma Inc.
|Preparation of multivesicular liposomes for controlled release of encapsulated biologically active substances
|Oct 1, 1996
|Dec 7, 1999
|Skyepharma Inc.
|Method for producing liposomes with increased percent of compound encapsulated
|Mar 23, 1995
|May 9, 2000
|Daiichi Pharmaceutical Co., Ltd.
|Liposomal products
|Aug 16, 1996
|May 9, 2000
|Supratek Pharma Inc.
|Polymer compositions for chemotherapy and methods of treatment using the same
|Feb 5, 1998
|Jun 6, 2000
|Skyepharma Inc.
|Multivesicular liposomes with controlled release of active agents encapsulated in the presence of a hydrochloride
|May 26, 1998
|Jul 4, 2000
|The Liposome Company, Inc.
|High drug:lipid formulations of liposomal-antineoplastic agents
|Mar 29, 1999
|Sep 19, 2000
|Nexstar Pharmaceuticals, Inc.
|Vinca-alkaloid vesicles with enhanced efficacy and tumor targeting properties
|Jul 9, 1998
|Sep 26, 2000
|Keith Baker
|Methods for universally distributing therapeutic agents to the brain
|Mar 20, 1998
|Oct 17, 2000
|Skyepharma Inc.
|Multivesicular liposomes with controlled release of encapsulated biologically active substances
|Nov 1, 1999
|Jan 9, 2001
|Skyepharma Inc.
|Method for producing liposomes with increased percent of compound encapsulated
|Nov 1, 1999
|Feb 27, 2001
|Skyepharma Inc.
|Method for producing liposomes with increased percent of compound encapsulated
|Dec 6, 1999
|Jun 5, 2001
|Skyepharma, Inc.
|Method for producing liposomes with increased percent of compound encapsulated
|Jun 7, 1995
|Aug 14, 2001
|Gilead Sciences, Inc.
|Method of targeting a specific location in a body using phospholipid and cholesterol liposomes which encapsulate an agent
|Sep 8, 1997
|Oct 23, 2001
|Chiron Corporation
|High and low load formulations of IGF-I in multivesicular liposomes
|Sep 16, 1997
|Aug 6, 2002
|Skyepharma Inc.
|Epidural administration of therapeutic compounds with sustained rate of release
|Apr 1, 2005
|May 22, 2012
|Pacira Pharmaceuticals, Inc.
|Sustained-release liposomal anesthetic compositions
|Nov 13, 2002
|Aug 27, 2013
|Celator Pharmaceuticals, Inc.
|Lipid carrier compositions with enhanced blood stability
|May 21, 2012
|Sep 16, 2014
|Pacira Pharmaceuticals, Inc.
|Sustained-release liposomal anesthetic compositions
|Dec 31, 2003
|Mar 17, 2015
|Bharat Serums and Vaccines, Ltd.
|Non-pegylated long-circulating liposomes
|Apr 26, 2001
|Dec 13, 2001
|Alza Corporation
|Liposomes with enhanced circulation time and method of treatment
|Jan 20, 2004
|Oct 21, 2004
|The Regents Of The University Of California
|Method for loading lipid like vesicles with drugs or other chemicals
|Dec 31, 2003
|Jun 30, 2005
|Bharats Serums & Vaccines Ltd.
|Non-pegylated long-circulating liposomes
|Sep 27, 2002
|Nov 24, 2005
|Hill Knut R
|Methods and apparatus for extrusion of vesicles at high pressure
|Apr 1, 2005
|Apr 13, 2006
|Skyepharma Inc.
|Sustained-release liposomal anesthetic compositions
|Sep 18, 1997
|Apr 8, 1998
|Artur Herzog Dr. Mesmer
|Use of a liposome solution for enhancing the activity and/or reducing the toxicity of drugs
|Nov 18, 1988
|Jun 1, 1989
|Vestar Inc
|Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
|Oct 3, 1989
|Apr 19, 1990
|Vestar Inc
|Method of making liposomes with improved stability during drying
|Aug 13, 1997
|Feb 26, 1998
|Valery Y Alakhov
|Improvements in polymer compositions for chemotherapy and methods of treatment using the same
|U.S. Classification
|424/450, 424/491, 514/908, 424/493
|International Classification
|Cooperative Classification
|European Classification
|May 16, 1988
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Designed for industrial-grade jobs, the DeWalt D28493N Heavy Duty 9-inch Large Angle Grinder comes with a 4.0 HP (15.0 Amp), 5,000 RPM motor with overload protection for high operating speeds under load. This grinder's low 5,000 RPM speed is optimal for sanding discs and specialty wheels, and its epoxy coated field and armature provide long service life against abrasion from airborne debris. A keyless adjustable guard is included for guard adjustments to be made without tools. Other features include a low-profile gear case for working in tight areas and automatic turn-off brushes that shut down the tool when brushes need to be changed to avoid tool damage. A 5-position side handle provides improved ergonomics for specific applications and a 2-wire double insulated "S" jacket rubber cord provides increased durability and life in hot and cold climates. This grinder comes with a 9-inch guard and a 5-position side handle.
DEWALT D28493N Heavy Duty 9-Inch Large Angle Grinder


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Panoramic Pavilion in Balboa Park, San Diego, California Photographic Print on Canvas
This seat stacking chair is perfect for individual or mass seating needs! It can be stacked 12 chairs high which optimizes storage space. It also comes with stacking bumpers to prevent scratches. This convenient stacking chair is one of the most popular with KFI.
Special Offer:
12 Issues of Golf Magazine
Included with purchase ($20 value).
Weights & Dimensions
|Product Type: Multipurpose
|Base Type: Four legs
|Style: Contemporary
|Frame Material: Steel
|Seat/Back Material: Fabric
|Number of Items Included: 1
|Wheels Included: No
|Padding Included: Yes
|Commercial Use: Yes
|Eco-Friendly: No
|Country of Manufacture: United States
|GSA Approved: Yes
About the ManufacturerKFI Seating's growth and expansion over the past several years has been no accident. Their philosophy is based on listening to customer's needs and adapting to the changing market conditions. As a result, KFI Seating has transformed itself into a furniture company with products to fit almost any seating solution. They will continue to evolve based on the needs of their customer. KFI Seating pledges commitment to improving and strengthening their operation with the customer's satisfaction in mind.
KFI Seating products are covered by a ten year limited warranty.
More About This Product
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Overall Rating
Based on 2 reviews
Customer PhotosAdd your own photo
Comfortable chair Lorane from United States on 11/25/2013 – Verified Buyer
Chair was just as described. It is sturdy and the seat was well padded and more comfortable than many chairs of this kind.
Was this helpful? Yes 0 No 0
Very satisfied Lise from Toronto on 02/14/2012 – Verified Buyer
Like the color, the weight and the quality.
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text:
1. Now we have airconditioning in the gymnasium, to keep training tempreture under control (Thanks to all competitive boys program families that participated in the fundraising for it)
2. Full surface of the Gymnasium is refilled with 20cm thick mats, making it more comfortable and safe (Thanks to all volunteers parents and volunteers coaches, that helped to deliver and install it)
3. Two new water bubblers are installed to the Gymnasium area.
4. Dance room now also have full time set up mini gym with the beam and sprung floor line
5. Sprung floor in the main gym is now larger by 1.1 miter on the length of the side of the floor.
6. New lighting in the gymnasium installed
Sydney Hills Gymnastics
Address: 3/4 Gladstone Road Castle Hill
NSW 2154 Australia
Email: firstname.lastname@example.com
Ph 02 9659 9010 Mob: 0421 895 803
Copyright (C) 2012 Sydney Hills Gymnastics


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- Duration 6 hours
- Updated Tuesday 19th July 2011
- Introductory level
- Posted under Professional Development in Education
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Thinking about how I work with other professionals
In this unit you will be building on your previous study and experience of 'working with others'. Using the notion of 'teamwork', you will be asked to think specifically about the values and beliefs underpinning the following three aspects of practice:
developing working relationships with other professionals;
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working in cooperation with other professionals.
This material is from our archive and is an adapted extract from Personal Professional Development: Early Years Settings (E115) which is no longer taught by The Open University. If you want to study formally with us, you may wish to explore other courses we offer in this subject area [Tip: hold Ctrl and click a link to open it in a new tab. (Hide tip)] .
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text:
phase-conjugate graviton emitter
This engineering device is occasionally employed by tractor beams, allowing them to lift more. It was used in 2373 to pull a nearly buried Jem'Hadar ship out of the ground of a Gamma Quadrant world and back to Deep Space Nine for study.
Star Trek: The Visual Dictionary Book
$20.00Buy Now
Star Trek Original Series Phaser Universal Remote Control
$149.95Buy Now


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text:
SKP Steel Industries Private LimitedKolkata, West Bengal
M S PipeM S Pipe
Company Profile
From what started as a small enterprise with a big dream, SKP Steel Industries (P)ltd. is today a name to reckon with. Established in the year 2006, SKP Steel is one of East India's fastest growing manufacturer of steel wires and Steel Pipes.
Fact Sheet
|Year of Establishment
|Nature of Business
Contact UsSKP Steel Industries Private LimitedAyush PasariView Contact Number+91-33-22640025
No. 41A, A.J.C. Bose Road
Kolkata - 700017
West Bengal, India
Kolkata - 700017
West Bengal, India
Send your enquiry to this supplier


text:
Checking inventory..
Lady Luck will smile on the River Hawks when you give a team-spirited show of good fortune with this St. Paddy's tee. The front features the school and team names printed over a shamrock graphic with a green logo at the bottom.
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Judge Dan
Dan Smith has been exposing anti-Israel fallacies since the first time he opened the world wide web on Netscape Navigator, sometime in the late 90's. His lack of formal journalistic, political and sociological education means he is still capable of objective, unbiased views and opinions. A judge of media, pundits and media pundits.
Latest posts by Judge Dan (see all)
- Arab Social Media Going On A Wild Goose Chase - August 2, 2015
- No, Israel Did Not Clear A Refugee Camp Inside Syria - July 13, 2015
- The World According To UNHRC Condemnation - June 25, 2015
- Terror-ble Palestinian Kindergarten Plays - May 27, 2015
- Gaza Kindergarten Play From Hell - May 24, 2015
Every unexplained piece of equipment in Lebanon is a Zionist Death Weapon.
resident at the bordering town of Blida reported finding an Israeli spying device. A security source said that an army unit and several members of the United Nations Interim Force in Lebanon deployed at the scene to launch an investigation. After arriving to the scene, security forces said that the device was a barometer installed by UNIFIL's French contingent.
Stay classy Lebanon.


text:
InventHelp Reviews
Here you will find reviews about America's largest and most experienced invention company. InventHelp tries to submit clients' inventions to industry in the hope of gaining a good-faith review, and our patent referral services have helped inventors secure more than 7,000 U.S. patents.
InventHelp Reviews
- 7 Pins
InventHelp's INPEX® 2013 was held June 19-21, at the beautiful David L. Lawrence Convention Center, in downtown Pittsburgh, Pennsylvania. This was the 28th INPEX, which featured more than 1,000 inventions and new products on display for review.
1 000 Inventions, Convention Center, 2013, Features, Display, Downtown Pittsburgh, Beautiful David, 28Th Inpex, 19 21
1InventHelp's INPEX® 2013 was held June 19-21, at the beautiful David L. Lawrence Convention Center, in downtown Pittsburgh, Pennsylvania. This was the 28th INPEX, which featured more than 1,000 inventions and new products on display for review.
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Pharmacy Technician – Infusion (Per Diem) – Columbia MD
CVS Health — Columbia, MD
Job Category: Pharmacy Technician Clinical Licensure Required : Pharmacy Technician Job Type: Per Diem Position Summary: At Coram CVS/specialty infusion services, we have a uniquely rewarding setting…
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Medical Instrument Technician (Vascular)
Department of Veterans Affairs — Baltimore, MD
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Gary Hilliard
Published: Thursday, December 27, 2012 at 4:24 p.m.
Last Modified: Thursday, December 27, 2012 at 4:24 p.m.
Gary Dalton Hilliard, 64, of Old Linwood Road, died Thursday, Dec. 27, 2012, at Wake Forest Baptist Health — Lexington Medical Center.
Arrangements are incomplete at Davidson Funeral Home.
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text:
Baked French Toast with Fruit Topping
- Active Time 25m
- Total Time 2h 40m
Serves 4
Called pain perdu, "lost bread," in French, this recipe rescues yesterday's bread by soaking it in an egg mixture before cooking. In a departure from tradition, these directions call for baking rather than frying French toast, with delicious results.
- 8 eggs
- 3 cups heavy cream
- 1 tablespoon granulated sugar
- 1/4 teaspoon ground nutmeg
- 1/2 teaspoon vanilla extract
- 4 slices dense-textured white sandwich bread or brioche, each 1 inch thick
- 8 tablespoons unsalted butter
- For Topping:
- 2 oranges, peeled and sectioned
- 1/2 cup blueberries
- 1/2 cup raspberries
- 1/2 cup blackberries
- 8 strawberries, stems removed and halved lengthwise
- 1 tablespoon granulated sugar
- 2 tablespoons Grand Marnier or other orange-flavored liqueur
- Confectioners' sugar
- Fresh mint sprigs
- Maple syrup, warmed
In a bowl, whisk together the eggs, cream, granulated sugar, nutmeg and vanilla until well blended. Pour the mixture into a glass baking dish large enough to accommodate the bread slices in a single layer. Place the bread slices in the dish and let soak for 15 minutes. Turn over the slices, cover the dish with plastic wrap and refrigerate for at least 2 hours or for as long as overnight.
Preheat an oven to 375 degrees F for 30 minutes.
Using a spatula, carefully remove the bread from the dish and transfer to a flat plate or baking sheet. Let stand for 2 minutes to drain off the excess batter.
In a large nonstick frying pan over medium heat, melt 2 tablespoons of the butter. Carefully slide a bread slice off the plate or sheet into the pan and cook until light golden brown on the underside, about 4 minutes. Turn over the slice and cook until lightly browned on the second side, about 2 minutes longer. Transfer the slice to a clean baking sheet. Repeat with the remaining butter and bread slices.
Place the toast in the oven and bake until cooked through, about 15 minutes. The toast will puff up during baking. To check for doneness, cut into the center of a piece. If it is still somewhat runny, cook for an additional 5 minutes.
FOR TOPPING: In a bowl, combine the orange segments, blueberries, raspberries, blackberries, strawberries, granulated sugar and liqueur. Toss gently.
TO SERVE: Transfer the toasts to warmed individual plates. Sift confectioners' sugar over the tops. Spoon equal amounts of the topping onto each plate. Garnish with the mint sprigs and serve with maple syrup.
Recipe reprinted by permission of Weldon Owen. All rights reserved.
RecID 759
nutrition information per serving
1141 calories; 101g total fat; 732mg cholesterol; 328mg sodium; 40g carbohydrates; 5g fiber; 20g protein
These nutrition facts are calculated according to the ingredients listed in this recipe. Any substitutions will change these facts. Although we strive for accuracy, please note that food manufacturers occasionally change their food formulas, which could affect the calculations as shown.
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On Blogger since May 2011
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- And Then There Were 4...
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|On October 3rd, 2009 I married my best friend and then shortly after I became pregnant. On a beautiful day in July 2010 our son was born. Being a first time mom there were many choices I was faced with. Do you cloth diaper or not? Do you breast feed or not? My son is now 1 and there were many things I learned in the first year and still learning about. The learning process has been fun because I love trying new products and sharing my review on it. I hope with this site I can share some of the products that I have tried and loved!