text: Romantic Boutique Email Share Tweet View All Hotels in 7th Arrondissement (Eiffel Tower) Hotel de l'Empereur 3.5 7th Arrondissement (Eiffel Tower), Paris, France Overview Photos (267) Room Details Amenities Travel Guide Map Check-In Check-Out Show Prices Provider Avg. Nightly Total w/ taxes and fees Please enter your dates above to compare your rates on over 200 booking sites including Expedia, Hotels.com, Booking.com, and others.Oyster searches hard to find you the best price! Photos and Review by Oyster.com Investigators


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Here at [LB] Laid Back Gaming we provide a friendly environment for the video game community. We have servers on Call Of Duty 4, AlterIW Net, and hopefully Call Of Duty 2.
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subset: commoncrawl


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NYCC PREVIEW: DC Debuts Miller, Janson & Kubert's "Dark Knight III" Interior Art
Comic Books
Showing results 91-140 of 3376
Guardians Team-Up #7
Drax and Ant-Man team up to stop an intergalactic arms deal in Nick Giovanetti, Paul Scheer and Shawn Crystal's "Guardians Team-Up" #7.
|July 3rd, 2015
A-Force #2
While no one punches any sharks in "A-Force" #2, Maguerite Bennett, G. Willow Wilson and Jorge Molina give readers plenty to enjoy.
|July 3rd, 2015
Secret Wars #4
Jonathan Hickman, Esad Ribic and Ive Svorcina deliver a strong, character-centered chapter in "Secret Wars" #4 that both moves the story along and serves as a great examination of Drs. Doom and Strange.
|July 2nd, 2015
E is for Extinction #1
"E is for Extinction" by Chris Burnham and Ramon Villalobos explores what would have happened if Xavier had died during Grant Morrison's original run on "New X-Men."
|June 29th, 2015
Planet Hulk #2
Steve Rogers and Devil Dinosaur continue to wander Greenland and come across Doc Green in Sam Humphries and Marc Laming's "Planet Hulk" #2.
|June 29th, 2015
Quake and Mister Hyde meet up with Phil Coulson and his crew in Mark Waid and Greg Smallwood's "S.H.I.E.L.D." #7.
|June 29th, 2015
Ant-Man: Larger Than Life #1
Set "Years Ago," Will Corona Pilgrim and Andrea Di Vito's "Ant-Man: Larger Than Life" #1 peeks into the past of the Marvel Cinematic Universe's Ant-Man.
|June 26th, 2015
Age of Ultron vs. Marvel Zombies #1
James Robinson delivers some entertaining surprises in "Age of Ultron vs. Marvel Zombies" #1, but Steve Pugh and Ron Garney deliver more consistency across a diverse array of styles.
|June 26th, 2015
Korvac Saga #1
Members of the creative crew and cast of characters from the recently-completed "Guardians 3000" find their way into Dan Abnett and Otto Schmidt's "Korvac Saga" #1.
|June 25th, 2015
Howard the Duck #4
Howard, Tara and Dr. Strange try to stop Tellos from assembling the Abundant Glove in Chip Zdarsky and Joe Quinones' "Howard the Duck" #4.
|June 25th, 2015
Ms. Marvel #16
In G. Willow Wilson and Adrian Alphona's "Ms. Marvel" #16, Kamran goes looking for Kamala as she tries to protect her family and fellow citizens in the "Last Days" of Jersey City.
|June 22nd, 2015
Old Man Logan #2
Brian Michael Bendis and Andrea Sorrentino's "Old Man Logan" #2 sends Logan over the wall, where he finds a batch of familiar faces and even more familiar trouble.
|June 19th, 2015
Runaways #1
It's final exam time at the Victor Von Doom Institute for Gifted Youths in Noelle Stevenson and Sanford Greene's "Runaways" #1.
|June 16th, 2015
Squadron Sinister #1
A promising cover by Carlos Pacheco and Mariano Taibo gives way to an even deeper and more engaging character-driven story by Marc Guggenheim in "Squadron Sinister" #1.
|June 16th, 2015
Thors #1
In "Thors" #1, Jason Aaron and Chris Sprouse give some personality to the Thor corps that patrol Battleworld in "Secret Wars."
|June 16th, 2015
Silver Surfer #12
Life is a little too perfect on New Newhaven but, despite the predictable (and slightly rushed) plot, Dan Slott, Michael Allred and Laura Allred still bring some charm to "Silver Surfer" #12.
|June 12th, 2015
1602 Witch Hunter Angela #1
Angela and Serah hunt the Witchbreed in Marguerite Bennett, Kieron Gillen, Stephanie Hans and Marguerite Sauvage's "1602 Witch Hunter Angela" #1.
|June 12th, 2015
Mrs. Deadpool and the Howling Commandos #1
"Mrs. Deadpool and the Howling Commandos" #1 is a complete misnomer of a title, as writer Gerry Duggan, artist Salva Espin and Deadpool himself demonstrate to readers in this "Secret Wars" spinoff.
|June 11th, 2015
Captain Marvel & the Carol Corps #1
Taking to the skies of Battleworld, Kelly Sue DeConnick, Kelly Thompson and David Lopez introduce Carol Danvers and the Banshee Squadron in "Captain Marvel and the Carol Corps" #1.
|June 11th, 2015
Marvel Zombies #1
Simon Spurrier and Kev Walker's "Marvel Zombies" #1 introduces readers to the Shield and its tough-as-nails Section Commander, Elsa Bloodstone.
|June 11th, 2015
Weirdworld #1
Jason Aaron and Mike Del Mundo cobble together elements from the Marvel multiverse that don't fit anywhere else within "Secret Wars" and build a splendidly rich, darkly beautiful world of fantasy adventure in "Weirdworld" #1.
|June 9th, 2015
Ghost Racers #1
On the outskirts of Doomstadt, the capital of Battleworld, sits the Killiseum, where five creepy combatants compete in Felipe Smith and Juan Gedeon's "Ghost Racers" #1.
|June 9th, 2015
Giant Size: Little Marvel: AvX #1
Skottie Young delivers a few kid-size laughs while never being worse than amusing in the form of "Giant Size: Little Marvels: AvX" #1.
|June 8th, 2015
Armor Wars #1
"Armor Wars" #1 brings readers to the domain of Technopolis, where writer James Robinson and artist Marcio Takara introduce Baron Tony Stark.
|June 5th, 2015
Secret Wars #3
Sheriff Strange discovers some unexpected survivors in Jonathan Hickman and Esad Ribic's "Secret Wars" #3.
|June 5th, 2015
Future Imperfect #1
"Secret Wars" gives Peter David and Greg Land a chance to revisit the world of the Maestro in "Future Imperfect" #1, and it's definitely one of the better attempts in the event to evoke an earlier era.
|June 5th, 2015
Star Wars #6
In "Star Wars" #6, writer Jason Aaron sends artist John Cassaday off with a new character addition and a fight between Boba Fett and Luke Skywalker.
|June 5th, 2015
Years of Future Past #1
Marguerite Bennett and Mike Norton go back to the future to visit with Kate Pryde and company in "Years of Future Past" #1.
|June 5th, 2015
X-Tinction Agenda #1
Marc Guggenheim and Carmine Di Giandomenico take readers on a welcome return to a classic X-Men storyline in "X-Tinction Agenda" #1, a "Secret Wars" tie-in that works well both within the confines of that event as well as on its own.
|June 4th, 2015
Spider-Woman #8
Dennis Hopeless and Javier Rodriguez bring their first arc on the series to an emotionally satisfying conclusion in "Spider-Woman" #8.
|June 4th, 2015
Groot #1
In "Groot" #1 by Jeff Loveness and Brian Kesinger, Groot and Rocket Raccoon try to hitchhike to Earth with unpredictable and hilarious results.
|June 2nd, 2015
Amazing Spider-Man: Renew Your Vows #1
Peter must make a difficult choice for the future of his family in Dan Slott and Adam Kubert's surprisingly dark "Amazing Spider-Man: Renew Your Vows" #1.
|June 2nd, 2015
Secret Wars 2099 #1
"Secret Wars 2099" #1 by Peter David and Will Sliney is a "Secret Wars" event tie-in, but it reads like a regular debut comic, one that is devoted to introducing a new team: Avengers 2099.
|June 1st, 2015
M.O.D.O.K.: Assassin #1
"M.O.D.O.K.: Assassin" #1 seems to be going for comedy, but Christopher Yost, Amilcar Pinn, and Terry Pallot's story of M.O.D.O.K. in the realm of Killville never quite hits its target.
|June 1st, 2015
X-Men '92 #1
Chris Sims, Chad Bowers and Scott Koblish take readers back to the '90s in the fun Infinite Comic, "X-Men '92" #1.
|May 29th, 2015
All-New Hawkeye #3
"All-New Hawkeye" #3 puts Clint and Kate on a S.H.I.E.L.D helicarrier, where writer Jeff Lemire and artist Ramón Pérez reveal "it ain't all flying cars and super spies."
|May 29th, 2015
Secret Wars Journal #1
In "Secret Wars Journal" #1, Pru Shen, Matthew Rosenberg, Ramon Bachs and Luca Pizzari reimagine two tales from properties like Punisher and Moon Knight.
|May 29th, 2015
Where Monsters Dwell #1
Under the "Secret Wars" banner, writer Garth Ennis and artist Russ Braun bring the Phantom Eagle back to action in the pages of "Where Monsters Dwell" #1.
|May 29th, 2015
Inferno #1
"Inferno" #1 has Dennis Hopeless and Javier Garron take us to a portion of Battleworld where Limbo's demons reign supreme, but fans of the original crossover won't find much more than superficial connections between the two.
|May 29th, 2015
Old Man Logan #1
In Brian Michael Bendis and Andrea Sorrentino's amazing "Old Man Logan" #1, Logan is a drifter trying to fix a world he helped break.
|May 28th, 2015
Inhumans: Attilan Rising #1
The Voice Unheard reaches out to Greenland to spread the message of resistance in Charles Soule and John Timms' "Inhumans: Attilan Rising" #1.
|May 28th, 2015
The Infinity Gauntlet #1
Dustin Weaver and Gerry Duggan deliver a high-octane cosmic adventure in "The Infinity Gauntlet" #1.
|May 28th, 2015
Deadpool's Secret Secret Wars #1
Cullen Bunn and Matteo Lolli's "Deadpool's Secret Secret Wars" #1 humorously retcons the original 1984 event by giving the Merc With A Mouth a starring role.
|May 25th, 2015
Guardians of the Galaxy #27
Brian Michael Bendis and Valerio Schiti bring this volume of "Guardians of the Galaxy" to a close in its 27th issue.
|May 25th, 2015
Ultimate End #1
Brian Michael Bendis and Mark Bagley smash together the 616 and 1610 universes just in time for the end of the world in "Ultimate End" #1.
|May 22nd, 2015
Secret Wars: Battleworld #1
Joshua Williamson and Mike Henderson go for straightforward action while Ed Brisson and Scott Hepburn go more for laughs in "Secret Wars: Battleworld" #1.
|May 21st, 2015
Daredevil #15.1
Mark Waid and Chris Samnee welcome Marc Guggenheim and Peter Krause to "Daredevil" #15.1, giving readers a peek into "Man Without Fear: The Autobiography of Matt Murdock."
|May 21st, 2015
Master of Kung Fu #1
Haden Blackman and Dalibor Talajic bring readers to Battleworld's domain of K'un Lun as the Thirteen Chambers gather to determine their future ruler.
|May 21st, 2015
Uncanny X-Men #34
Brian Michael Bendis and Kris Anka wrap up the series' dangling plot thread involving Mystique in "Uncanny X-Men" #34 and, in a way, that feels remarkably satisfying.
|May 20th, 2015
Spider-Verse #1
Five Spiders collide on Battleworld in Mike Costa, Andre Araujo and Steven Sanders' "Spider-Verse" #1.
|May 20th, 2015


text:
China discovers another 22 fake Apple StoresAn investigation into retail stores purporting to be run by Apple in the southwestern Chinese city of Kunming has identified 22 phony storefronts operating under the company's logo.
According to a report by Reuters the stores have been ordered to stop using Apple's logos after Apple China complained of unfair competition and violation of its registered trademarks.
The investigation was tipped off by a blog post by an American living in the city who reported on knockoff Apple Stores that were so convincing that even their employees thought they were working for the Cupertino-based company.
The outlets appear to be selling actual Apple products, although they are in many cases smuggled into the country to avoid paying taxes. Customers who discovered the stores were not really begin run by Apple ranged from upset and demanding refunds for their purchases to being unfazed by the ownership of the store, as long as the merchandise was legitimately from Apple.
Apple only operates four stores in China, although it announced plans to open 25 in the near future. The company's revenues in the Greater China region (including Hong Kong and Taiwan), have exploded by a factor of six to reach $3.8 billion in the last reported quarter.
Credit: BirdAbroad
Credit: BirdAbroad
On Topic: General
- Antitrust monitor again bemoans Apple's lack of cooperation in final report
- Microsoft's retail store chain flounders in stark contrast to busy Apple Stores
- Microsoft debuts Lumia 950 & 950XL phones, Display Dock, Band 2 fitness tracker
- Microsoft unveils Surface Book laptop & Surface Pro 4 tablet with new Surface Pen
- From analog to digital: How Danny Boyle's 'Steve Jobs' captures the rapid advancement of technology


text:
Deadfall Trail
Not Available
- movie Description
John, Julian and Paul enter the Kaibab National Forest for a three-week survival trip and peyote vision quest. The only items they each take with them are a knife, a bottle of water and a garbage bag. A week into their journey a disastrous turn of events changes everything and the men are forced to ultimately confront the darkest corners of their morality and mortality. Battling the elements and each other, the quest becomes to make it out of the forest alive.moreless
- Trailer
- Cast & Crew
Richard Anderson
Shane Dean
- Fan Reviews
- Be the first to write a review!
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Narrow your search
New government rules will see a new 12 rating on video games along with prison sentences for retailers who fail to comply.
The 2013 Subaru BRZ's reputation precedes it, for better or worse. We take a spin (on the road and the track) to cut through the hype.
With Wednesday's recall of the 2003 Sequoia SUV, the Japanese carmaker is dealing with a string of computer-related problems this year.
2006 BMW M6 Coupe first take
2006 BMW M5 first take
Remember the old classic carol The Twelve Days of Christmas? Denise Shelton delves into just where you can buy your partridge in a pear tree online.


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text:
March 19, 1998 in Idaho
Conviction Upheld
The Idaho Supreme Court has upheld the conviction and death penalty for triple murderer Robin Row for setting the fire that killed her husband and two children in 1992.
It ruled the district court did not err in sentencing the Boise woman, finding it carefully considered Row's application for post-conviction relief and was correct in denying it.
The court also found that the aggravating factor of "multiple murders" was correctly weighed against mitigating circumstances.
In the early hours of Feb. 10, 1992, a fire broke out at Row's townhouse apartment. Fire crews found the bodies of her husband, Randy Row, and her two children, Joshua and Tabitha. All had died of carbon monoxide. Investigators discovered a flammable liquid was used to start the blaze and that the smoke detector was disabled.
Row was convicted on March 5, 1993, and sentenced on Dec. 16.
© Copyright 1998 Associated Press. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.


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text:
Caution and Skepticism as Iran Nuclear Talks Resume in Vienna
Iran, six world powers to kick off three-day talks in Vienna over permanent nuclear agreement.
VIENNA - Iran and the six world powers will open talks on a permanent nuclear agreement in Vienna on Tuesday, but both sides say they have doubts about the chances of a breakthrough that would bridge the sizable gaps between their positions.
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text:
By Biiwii
SPX has popped to resistance at the top of a 'W' pattern and halted there. This is a valid termination point. The chart however, has higher levels where the bounce, which was anticipated since before the Tinder Box post, can terminate. The 2000 area, 2040 and a measurement of the 'W' to around 2120 are the next levels.
As it is, the bounce has gone high enough to get CNBC and Cramer to start rethinking the well publicized bearishness.


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Easton Elite wins 10u SoCal Regional
Matt Rodriguez
Friday, February 21, 2014
CARTERSVILLE, Ga. - While the 35-7 run differential for Easton Elite's 10u team may suggest otherwise, the scrappy youngsters from Southern California had to string together a couple of come-from-behind wins on their way to becoming PG Super25 10u SoCal Regional champions in the tournament series' first ever SoCal Regional, played February 15th-17th in Baldwin Park, Calif.
After coasting to wins of 8-0 and 16-1 in the first two games, it took some perseverance out of the young Easton Elite team to overcome deficits in the semi-final and championship games.
"At the end of the day, it was just a matter of execution, both on offense and defense," said coach Daniel Ramirez. "The kids went out there and they played hard over the weekend and they had a blast doing it. I think this weekend was a perfect example of good coaching and great execution by these kids."
OF/3B Joey Godoy was the engine behind many key two-out rallies for Easton Elite in the semi-final and championship games. As important as his bat was, his defense stood out to the coaches as well.
"He threw out a kid at third on a no-hop throw and he threw another kid out at home plate on a line drive base hit," mentioned Ramirez on Godoy's outfield play.
Easton Elite was able to get by Diamond MVP in the semi-finals by a 5-4 score and come from behind to defeat Team Rawlings in the championship game, 6-2, thanks in large part to Godoy's clutch performance.
RHP/SS Luke Mistone's pitching performance also came to mind when asked what it took for Easton Elite to come out on top in the PG Super25 10u SoCal Regional. "He kept one of the best teams in Southern California down to one run the entire game," said Ramirez.
It was RHP/3B Jesse Villalobos, however, whom Ramirez named MVP of the tournament for his 10u Easton Elite team.
"He had the keys hits -- making solid contact and driving kids in," Ramirez said. "He's another one who started off a lot of our rallies and defensively he's a stud on the mound."
While Ramirez contributes a lot of Easton Elite's tournament success to these three young players, he emphasized the fact that his team played together and executed when they needed to, displaying a perfect example of playing as a team.
"We make sure that the kids we have on this team have that dedication and passion for the game," said Ramirez. "What we teach them is you respect the game, you respect your opponent, and you respect your teammates."
Easton Elite became the first ever PG Super25 10u SoCal Regional champions in the tournament series' inaugural event, one Ramirez said was very enjoyable for the players and the parents in attendance.
"You couldn't ask for better weather than what we had over the weekend, and the competition was great," said Ramirez.
The Super25 tournament series will continue for the 10u Easton Elite team, who earned a spot in the PG Super25 10u National Championship, July 11th-15th in Charleston, S.C.
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My daughter is being bullied by group of girls she wont let me do anything what can I do?
My daughter is 16 and very pretty has alot of friends but a group of girls are always calling her names and threatening to kick her butt. She wont let me call anyone what can I do? She handles it well but they are ruining her reputation by the things they say.One of her friends is friends with them and constantly back stabs her which just adds fuel to the fire. I dont know if I should call the parents or let her handle it.In Topics: Bullying and teasing
> 60 days ago
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Page 1
Modeling epidemics of multidrug-resistant M. tuberculosis of
heterogeneous fitness
Ted Cohen1 and Megan Murray1,2
1Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston,
Massachusetts 02115, USA.
2Infectious Disease Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02115,
Mathematical models have recently been used to predict the future burden of multidrug-resistant
tuberculosis (MDRTB)1-3. These models suggest the threat of multidrug resistance to TB control
will depend on the relative 'fitness' of MDR strains and imply that if the average fitness of MDR
strains is considerably less than that of drug-sensitive strains, the emergence of resistance will not
jeopardize the success of tuberculosis control efforts. Multidrug resistance in M. tuberculosis is
conferred by the sequential acquisition of a number of different single-locus mutations that have been
shown to have heterogeneous phenotypic effects. Here we model the impact of initial fitness estimates
on the emergence of MDRTB assuming that the relative fitness of MDR strains is heterogeneous.
We find that even when the average relative fitness of MDR strains is low and a well-functioning
control program is in place, a small subpopulation of a relatively fit MDR strain may eventually
outcompete both the drug-sensitive strains and the less fit MDR strains. These results imply that
current epidemiological measures and short-term trends in the burden of MDRTB do not provide
evidence that MDRTB strains can be contained in the absence of specific efforts to limit transmission
from those with MDR disease.
Tuberculosis (TB) is a global health emergency that demands concerted management efforts.
Recent World Health Organization reports reveal that MDRTB is a substantial problem in
every region evaluated4. However, the impact of the emergence of multidrug-resistant (MDR)
strains on global TB control remains unclear. Throughout much of the world, control strategies
include case detection through sputum microscopy and standardized treatment regimens
administered without drug sensitivity testing. Although this approach is effective in managing
TB that is drug-sensitive or resistant to one antibiotic, it neither detects nor cures the majority
of cases of MDRTB.
This exclusive focus on drug-sensitive and monoresistant tuberculosis arises from two
considerations. The first is the cost and complexity of detecting and treating drug-resistant
tuberculosis, and the second is the perception that drug-resistant pathogens are less likely to
cause epidemics than drug-sensitive ones. This perception is based on the observation that
mutations that confer resistance often alter gene products important for the pathogen's survival
and thus exact a 'fitness cost'5.
Correspondence should be addressed to M.M. (firstname.lastname@example.com)..
Note: Supplementary information is available on the Nature Medicine website.
COMPETING INTERESTS STATEMENT The authors declare that they have no competing financial interests.
NIH Public Access
Author Manuscript
Nat Med. Author manuscript; available in PMC 2009 March 9.
Published in final edited form as:
Nat Med. 2004 October ; 10(10): 1117–1121. doi:10.1038/nm1110.
NIH-PA Author Manuscript
NIH-PA Author Manuscript
NIH-PA Author Manuscript
Page 2
Mathematical models have been developed to describe the transmission dynamics and the
impact of interventions for many infectious diseases6,7, including drug-sensitive8-11 and
drug-resistant tuberculosis1-3,12. Previous work on the population dynamics of drug resistance
has shown that the fitness of drug-resistant strains is a key determinant of the future burden of
drug-resistant pathogens in general13,14 and specifically of drug-resistant TB1 and
MDRTB2,3. When the average fitness of MDR strains is assumed to be substantially less than
drug-sensitive strains, these models predict that the emergence of multidrug resistance will not
jeopardize the success of control efforts that focus on the treatment of drug-sensitive disease.
The reproductive fitness of an individual strain of M. tuberculosis is a complex characteristic
determined by the bacterium's ability to infect a susceptible host, persist and proliferate, and
be transmitted to a secondary host. Laboratory studies comparing the relative fitness of drug-
resistant and drug-sensitive organisms through competition assays have found that although
some mutations compromise growth and the ability to survive oxidative stress15, others have
minimal in vitro effects. Furthermore, when fitness costs were detected, they were often short-
lived because compensatory mutations rapidly accumulated to restore biological function16.
The results of empirical studies that have compared the reproductive potential of drug-resistant
and drug-sensitive strains in human populations have been similarly heterogeneous; some
reports indicate that drug-resistant strains of M. tuberculosis spread less readily than drug-
sensitive strains17, whereas others show no difference in disease transmission18.
Despite the heterogeneity in the fitness of MDR strains suggested by the studies cited, previous
models of the transmission dynamics of drug-resistant TB have assumed a single fixed value
of average fitness for MDR strains. Given that drug-resistant strains of M. tuberculosis show
a range of fitness19, we constructed a model that incorporates the emergence of multidrug
resistance during therapy, heterogeneity of fitness of MDR strains, and competition during an
epidemic (Fig. 1). Following previous TB models, we assumed that susceptible individuals are
infected at a rate that is proportional to the prevalence of people with active disease; once
infected, individuals progress to disease through a fast route (primary disease) or a slow route
(reactivation), and individuals who are infected but do not have active disease may become
reinfected (exogenous reinfection). To incorporate competition between MDR and drug-
sensitive organisms, we modeled three distinct strains: one that is drug-sensitive and two MDR
strains that differ in relative fitness compared to the drug-sensitive strain. The 'unfit' MDR
strain (designated by subscript 'U') has a low fitness (0.3) relative to the drug-sensitive strain,
whereas the 'fit' MDR strain (subscript 'F') has a relative fitness that ranges from 0.8 and 1.2
(Table 1). As evidence suggests that most mutations conferring a MDR phenotype will incur
an initial fitness cost, we assumed that mutation leads to the unfit MDR phenotype (aU) 100
times as often as the fit MDR phenotype (aF).
We initially modeled the course of a drug-sensitive tuberculosis epidemic prior to the
introduction of combination chemotherapy. This simulation yielded measures of disease
consistent with those from selected high-burden regions (Table 2a). We then modeled a 30-
year period before the introduction of Directly Observed Treatment, Short-course (DOTS)
treatment, during which drugs were available, but detection and cure rates reflected the
suboptimal program performance reported before the implementation of the DOTS strategy.
We estimated that approximately 3% of those with initially drug-sensitive disease who fail pre-
DOTS treatment acquired multidrug resistance (Table 1). The results of this simulation reflect
the current epidemiology observed in high-burden countries (Table 2b). These results also
show that the early course of the MDRTB epidemic is insensitive to the relative fitness of the
MDR phenotype, with negligible differences in the estimated burden of drug-sensitive or
MDRTB over a wide range of fitness costs.
Cohen and MurrayPage 2
Nat Med. Author manuscript; available in PMC 2009 March 9.
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To explore the long-term dynamics of MDRTB, we then modeled the implementation of the
DOTS program beginning 30 years after the initiation of unstructured treatment. We assumed
case detection and cure rates for drug-sensitive disease consistent with World Health
Organization goals21, improved treatment efficacy for MDR disease and a reduced proportion
of those acquiring the multidrug-resistant phenotype through failed treatment (Table 1). As
was observed in many countries that saw significant reductions in TB incidence after antibiotics
became available, drug-sensitive disease is rapidly brought under control through the
implementation of DOTS. In contrast to the short-term results discussed above, the simulated
long-term course of tuberculosis epidemics depends critically on the relative fitness of MDR
strains (Fig. 2).
In this simulation, almost all of the MDR cases generated early in the course of the epidemic
harbor the unfit strain; thus, the average fitness is low. When the prevalence of drug-sensitive
tuberculosis is reduced through the implementation of DOTS, the impact of acquired drug-
resistance on the emerging MDR epidemic becomes less important and the predominant driving
force of incident MDR infections shifts to the transmission of MDR strains. Consequently, the
fitness difference between the circulating strains becomes the primary determinant of new
infections and interstrain competition leads to the ascent of the most transmissible strains (Fig.
The model demonstrates that even when the most fit MDR strain is assumed to be less fit than
the drug-sensitive strain, the MDR strain will eventually outcompete the drug-susceptible strain
(Fig. 2b). However, there exists a fitness threshold for the 'fit' MDR strain below which
multidrug-resistant disease will not continue to spread as long as DOTS treatment goals are
met. In these simulations, this threshold is exceeded when the most fit MDR strains are greater
than 70% as fit as the drug-sensitive strains.
This model makes several simplifying assumptions. First, because the relationship between
contact patterns and the spread of airborne infections is not well understood, we modeled the
population as a homogenously mixing unit. Although this is oversimplified, we based this
decision on molecular epidemiological data that suggest substantial transmission of TB occurs
following casual contact with infectious TB cases26 and contact tracing fails to identify most
secondary cases27. Second, we modeled the acquisition of multidrug resistance as a single-
step process despite the fact that MDR is acquired through sequential accumulation of point
mutations. Because monoresistant strains are thus included in the drug-sensitive (non-MDR)
population, we may have underestimated the relative fitness of MDR strains in comparison to
the non-MDR strains in the model. Finally, we modeled tuberculosis dynamics in a limited set
of scenarios consistent with epidemiological data from developing countries. Recent work
demonstrates that tuberculosis dynamics are highly sensitive to the rate of infection and
suggests that it may not be possible to generalize our results to the setting of a developed country
in which the incidence and prevalence of tuberculosis are declining28.
Our model suggests that despite a short-term decline in the tuberculosis burden following the
implementation of DOTS, the exclusive treatment of drug-sensitive and monoresistant
tuberculosis may contribute to the emergence of MDR disease in at least two ways: (i) treatment
directly contributes to the pool of MDR cases through acquired resistance, albeit at much lower
rates under DOTS than pre-DOTS programs, and (ii) the removal of infectious individuals with
predominantly drug-sensitive disease decreases the force of infection and subsequently
replenishes the pool of individuals who are fully susceptible to infection with circulating MDR
Previous studies suggest that the fitness of MDR strains is heterogeneous. We demonstrate that
future burden of MDRTB is more dependent on the distribution of fitness among circulating
Cohen and MurrayPage 3
Nat Med. Author manuscript; available in PMC 2009 March 9.
NIH-PA Author Manuscript
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Page 4
strains than on the initial average reproductive fitness. We show that even if highly
transmissible MDR strains are only rarely generated through poor treatment, MDRTB may
eventually become a major public health threat. Our simulations indicate that DOTS policies
should be coupled with strategies to limit the spread of MDRTB (for example, DOTS-
plus29) in order to mitigate the long-term threat of MDR disease. Although an optimal approach
would include the concurrent administration of high-quality DOTS programs and the
introduction of second-line drug therapy for those with MDRTB, limited resources have made
this difficult to achieve. How this combined approach can best be implemented in resource-
constrained settings is a topic for urgent operational research.
Model structure
Our deterministic compartmental model is described by the set of ordinary differential
equations shown in Supplementary Methods.
Individuals are born susceptible to infection (S) and then may be infected with a circulating
strain of M. tuberculosis. The strain-specific infection rate is proportional to the prevalence of
individuals with active disease due to that strain and a strain-specific transmission parameter
β (1 – c), where c denotes the fitness 'cost' of the particular resistance phenotype of that strain.
Thus, for the drug-sensitive strain, c = 0. In this formulation, β is proportional to the probability
of a transmission event conditional on contact with an infectious individual and inversely
proportional to the population size; thus β has units of persons−1time−1.
A proportion (p) of the infected individuals transitions into a rapidly progressive state (E, EU
and EF), while the remaining infected individuals (1 – p) transition to a latent state (L, LU, and
LF). Those with latent infections progress to active disease at rate τ1, considerably slower than
those in the rapidly progressive state who transition to active disease at rate τ2.
A proportion of those developing active disease (f) is detected and treated (D, DU and DF),
while the remaining individuals (1 – f) with active disease remain undetected and untreated
(T, TU and TF). Those detected are processed and treated at rate κ. Of those with drug-sensitive
disease who are treated, a proportion g are cured while 1 – g fail. Those who fail may develop
drug resistance; a proportion of these (aU) acquires the 'unfit' MDR strain (YU), while a much
smaller proportion (aF) acquires the 'fit' MDR strain (YF). Those detected but not yet treated
(D, DU and DF) and treatment failures (Y, YU and YF) continue to be infectious.
Individuals with active disease self-cure at rate σ; we assume that those who self-cure transition
back into the corresponding latently infected state (L, LU or LF) and thus remain at risk for
reactivation. Treatment cures (R, RU and RF) relapse to disease at rate δ. A proportion (f) of
these relapses are detected and will be classified as treatment failures (Y, YU and YF) while the
remaining relapses (1 – f) remain undetected (T, TU and TF).
Except for those with active disease, all individuals with a history of infection may be reinfected
by another circulating strain. Prior infection affords partial immunity m to reinfection with any
strain. Previous models demonstrate that exogenous reinfection of individuals plays an
important role in tuberculosis epidemics in high-incidence areas10 and epidemiologic studies
confirm that reinfection is common in settings where transmission is intense30.
Individuals die at a fixed mortality rate μ; those with active disease will also die at an increased
tuberculosis-specific rate ϕ. All deaths are replaced by births into the susceptible state.
Cohen and MurrayPage 4
Nat Med. Author manuscript; available in PMC 2009 March 9.
NIH-PA Author Manuscript
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Modeling the fitness cost of drug resistance
The dynamics of the MDR strains differ from the drug-sensitive strain in two ways: the three
strains have different transmission parameters and the proportion of MDR cases cured on
therapy (gR) is smaller than the proportion of drug-sensitive cases cured (g). We modeled
different fitness costs for each of the two MDR strains, but assumed that treatment efficacy is
equivalent for both MDR strains. Although the MDR phenotype results from the stepwise
accumulation of mutations, we collapsed the parameters describing these sequential mutations
into a single step in a manner similar to that of other modelers2,3. This reflects the fact that
monoresistant strains can be controlled by the therapeutic regimens used in DOTS and
consequently will exhibit the same dynamics as do sensitive strains under this strategy. For
our base model, the values for all other parameters that describe the natural progression of
disease were identical for each of the three strains. Although our base model assumes that the
cost of fitness is entirely captured by reducing the transmissibility of MDR tuberculosis,
additional analyses demonstrate that MDR strains also outcompete drug-sensitive strains in
projected tuberculosis epidemics when fitness costs are instead exacted from the rates of
disease progression (data not shown).
Baseline model prior to the introduction of antituberculosis drugs
We used the historical data on the epidemiological indices of tuberculosis infection and disease
to calibrate the transmission parameter, β (Table 2). Because β is parameterized as persons−1
time−1, our fitted β reflects the choice of population under study. To facilitate comparison with
other models, we arbitrarily report the β for a population size of 1 million (Table 1) and modeled
the introduction of a single case of drug-susceptible tuberculosis into a hypothetical population
of 1 million individuals, allowing tuberculosis infection and disease to equilibrate. We used
time steps of 0.1 year and an Euler integration method.
We thank M. Lipsitch, B. Cooper, M. Becerra and M. Smurzynski for critical reviews of a draft of this manuscript.
1. Blower SM, Gerberding JL. Understanding, predicting and controlling the emergence of drug- resistant
tuberculosis: a theoretical framework. J. Mol. Med 1998;76:624–636. [PubMed: 9725765]
2. Dye C, Williams BG. Criteria for the control of drug-resistant tuberculosis. Proc. Natl. Acad. Sci. USA
2000;97:8180–8185. [PubMed: 10859359]
3. Dye C, Espinal MA. Will tuberculosis become resistant to all antibiotics? Proc. R. Soc. Lond. B. Biol.
Sci 2001;268:45–52.
4. World Health Organization. Anti-tuberculosis drug resistance in the world, report #3. WHO; Geneva:
5. Andersson DI, Levin BR. The biological cost of antibiotic resistance. Curr. Opin. Microbiol
1999;2:489–493. [PubMed: 10508723]
6. Anderson, RM.; May, RM. Infectious Diseases of Humans: Dynamics and Control. Oxford University
Press; Oxford: 1991.
7. Grenfell BT, Anderson RM. Pertussis in England and Wales: an investigation of transmission dynamics
and control by mass vaccination. Proc. R.. Soc. Lond. B Biol. Sci 1989;22:213–252. [PubMed:
8. Blower SM, Small PM, Hopewell PC. Control strategies for tuberculosis epidemics: new models for
old problems. Science 1996;273:497–500. [PubMed: 8662538]
9. Blower SM, et al. The intrinsic transmission dynamics of tuberculosis epidemics. Nat. Med
1995;1:815–821. [PubMed: 7585186]
Cohen and MurrayPage 5
Nat Med. Author manuscript; available in PMC 2009 March 9.
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Japan's Space Agency decides to call asteroid it will detonate explosives on in 2018 Ryugu - after an ancient story.
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After years of secret negotiations, Trans-Pacific Partnership deal to cut trade barriers is signed.
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Cause out here on the real streets, a dreamer always stay sleep
Lyric Meaning
Nice wordplay here: Dreams occur in the subconscious. When you are dreaming, you are not out living in the real world, hence you're "sleeping".
A deeper interpretation for this line could be using the world sleep to mean death. Trying to live a fantasy world where everything is ideal (dreamer) could end up getting you killed out on the streets. The line essentially parallel's the quote "I'll sleep when I'm dead".
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Geminid Meteor Shower
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This was my first attempt at photographing a meteor shower. I recently bought a DSLR and tripod and set out to capture the night sky. In all I took roughly fifty photographs that night and only two ended up with meteors in them!
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text: Robert Siegel Novelist Kamel Daoud, Finding Dignity In The Absurd By Robert Siegel • Aug 21, 2015 The most talked-about novel written in French recently is not by a Frenchman, but by an Algerian, newspaper editor Kamel Daoud. It's called The Meursault Investigation, and it's a response to the most famous novel ever written by a French Algerian, a mainstay of the 20th century canon: The Stranger, by Albert Camus. In Merkel's Uncomfortable Moment, A Glimpse Of Germany's Difficult Decisions By Robert Siegel • Jul 17, 2015 Copyright 2015 NPR. To see more, visit http://www.npr.org/. Transcript ROBERT SIEGEL, HOST: A moment now of reality colliding with politics. AUDIE CORNISH, HOST: At an event called Good Living in Germany, Chancellor Angela Merkel spoke with some schoolchildren. (SOUNDBITE OF ARCHIVED RECORDING) Nostalgic Cars: Sour Automotive Fruit Of Cuban Embargo Gets New Life By Robert Siegel • Mar 27, 2015 In Havana, Cuba, the old cars that crowd the streets used to symbolize a stagnant nation. Now enterprising Cubans have begun renting cars out to tourists who are hungry for the cars of their youth. During my reporting trip to Havana, I spoke with Julio Alvarez, the owner of Nostalgicar in Havana. He joked that one thing Cubans should thank Fidel Castro for is all the old, majestic American cars that are now making him money. You can listen to the story using the player above. A Fraying Promise: Exploring Race And Inequality In Havana By Robert Siegel • Mar 26, 2015 Miguel Coyula points at an open door in the middle of Old Havana. The mahogany door looks worn, but still handsome. The concrete facade has lost most of its paint, and time has ripped parts of it open. "That's marble," Coyula says, pointing to the treads of the staircase. "They are the remnants of something that was very glorious." Coyula is an architect and an economist, and as he walks through the streets of Havana, he doesn't just see breathtaking decay. He sees how economic policies and social circumstances have shaped this city. In Havana, A Journey Into The Forbidden With A Provocative Artist By Robert Siegel • Mar 25, 2015 It was still dark when Tania Bruguera hopped into a cab with us on her way to Revolution Square. "All of a sudden it looks quite subversive what we're doing," she said. Her voice revealed a little nervousness, but it translated into a giddy laughter. Pages« first ‹ previous 1 2 3 4 … next › last »


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Complete the form below to quickly retrieve sailing prices.
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The Annual Chili Cook-off is a popular fall event that features area chefs preparing their favorite chilies. The celebration gives patrons the chance to sample some great chilies and vote for their favorite, while enjoying live music and locally produced wines. Enjoy a hot bowl of chili on a colorful fall day at Hill Prairie Winery.
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The Fall Festival & Fish Fry is the perfect way to kick off fall in the beautiful rolling hills of Hill Prairie Winery. Enjoy the spectacular fall colors while enjoying fresh fried fish along with your favorite wines. Two great bands play each day. Check out their website for a full calendar of festivals and live music on Sundays at Hill Prairie Winery.
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January 2014, TruckingInfo.com - Feature
By Tom Berg
Over the Christmas holidays, the Salvation Army's bell ringers raise money to help fund its disaster and human-relief efforts. But considerable dollars also come from its daily pick-ups of donated household and office goods that are delivered to warehouses for sorting and refurbishment. These items are then resold in its Family Stores. For this, SA employs a fleet of medium-duty trucks.
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Jem'Hadar Strength
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May 5 2013, 02:58 AM
Captain McBain
Location: Being congratulated on the bridge of the Enterprise after making captain
Jem'Hadar Strength
Roughly how strong and fast is a Jem'Hadar soldier? About as fast and strong as a Vulcan?
How would a Jem'Hadar fare in a H2H fight with a Hirogen? The Hirogen was throwing around Tuvok in one episode, so they obviously have massive strength.
Also, would 5 Jem'Hadar soldiers have a chance against Data in an empty room, or should they just beam away as fast as they can?
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Norwegian Sun Cruise Review by BobCens: First T/A and First NCL
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First T/A and First NCL
It was a little hectic and warm as it is around the central Florida area this time of year when we checked on. The waiting line to board was bearable. Once the details were attended to we proceeded quickly to locate our cabin. Our bags were not there yet, so it was off the a nice meal, one of many in the Seven Seas dining room. We sailed just a little after five p.m. and headed out in the Atlantic on what was to be a number of wonderful weather days.
After reading some of the negative reviews posted on this site, we were apprehensive, but that soon faded away after the wonderful service and attitude of the ship's staff. We just can't say enough about the hotel and dining staff. They were attentive and friendly at all times. The food was very good to excellent. The entertainment was the best that one could hope for on a ship this size and number of days at sea. We saw at least 5 or 6 shows and were wowed each time at their professionalism. The person responsible for booking More (cruise director?) these performers deserves a raise.
Yes, sometimes the Garden Cafe buffet was hectic, but manageable. We tried to fit most of our eating to the Seven Seas dining room. We didn't visit the extra charge dining options. We did have the usual complaint of a out-dated TV system and yes, the internet connection if expensive and slow. These are minor issues and certainly didn't ruin our cruise. We really enjoyed visiting Punta Delgada. A group organized on the web pages of Cruise Critic provided us with a great deal of information and companionship that enhanced our experience. We did not participate in any NCL tours, but went off by ourselves or in a small groups assisted by members of this group that had visited these ports previously.
We stayed over 3 days in Copenhagen at the completion of our cruise and had a wonderful time. After 14 days of cruising and an additional 3 days of on-shore visiting we are two tired, but happy puppies.
Thanks to everyone who helped us along the way. Hope to see you again. Less
Published 05/15/11
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Find this book in a library near you, using WorldCat.org.
An illustrated biography and chronology of Martin Luther King Jr. and the Civil Rights Movement era.
legal, African American History Month, Black History, racism, black history month, nonviolence, African American history, civil rights, citizenship, African American, separate but equal, education, February, African-American History Month, desegregation, Black, equality, march, twentieth century, African-American
Most distinguished American picture book for children (annually).
Most distinguished contribution to American literature for children (annually).
Distinguished books by authors and illustrators of African descent which
promote an understanding and appreciation of the American dream
Outstanding examples of text, illustration, fiction and nonfiction (four awards annually).
Outstanding work of historical fiction published by a U.S. publisher set in the New World.
Support for Smithsonian's History Explorer is provided by the Verizon Foundation


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SYNOPSIS: "In a cyberpunk vision of the future, man has developed the technology to create replicants, human clones used to serve in the colonies outside Earth but with fixed lifespans. In Los Angeles, 2019, Deckard is a Blade Runner, a cop who specializes in terminating replicants. Originally in retirement, he is forced to re-enter the force when four replicants escape ...Read More »
Tag Archives: Sean Young
Film Review: Gingerclown (2013)
SYNOPSIS: 1983: A group of high school students are having a great time near Hollywood Hills at the weekend when they bump into the Loser from their school, Sam, who's just on his way home. Sam would do anything in order to get Jenny's attention, one of prettiest girls in school. Unfortunately she's also the girlfriend of the school's bully, ...Read More »
Film Review: Dune (1984)
SYNOPSIS: "It is a distant galaxy in the far future year of 10191. Arrakis is a desert planet and the only source of Melange, a vital drug used by the Guild Navigators for space travel from star system to star system. Two rival families, the Atreides and the Harkonnens, fight for control of the mining operations of Melange on Arrakis. ...Read More »
Film Review: Headspace (2005)
SYNOPSIS: 25-year-old Alex Borden is handsome, charming, and intelligent. In fact, he may be too smart for his own good as his life is swiftly becoming a living hell… REVIEW: If there's one thing that I hate, it's a horror movie with delusions of grandeur. Don't get me wrong…I can dig a horror movie with a "Message" every so often ...Read More »
Film Review: Haunted Echoes (2008)
SYNOPSIS: Guy and Laura have recently suffered a parent's worst nightmare: their eight-year-old daughter Kimberly was abducted from her bedroom and murdered. They move to a charming old house in need of repair, hoping the project will alleviate their pain but they soon find themselves haunted by a young female spirit; is it their daughter or another entity using the ...Read More »


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Filmed and edited by: Eric Arii (@ericarii)
Launched Kahana bay 0500, straight out 18 miles to LL buoy, first pass small Mahi in the boat, stoked no skunk but couldn't celebrate due to mild seasickness, the east side is no joke when the wind and swells are ganging up on you, worked the buoy for another hour with no love, switched out the lures to some of Sky's over ripe dead Opelu and managed to land a super hungry Ono, luckily it didn't scissor threw the light leader, still couldn't celebrate due to a twisted stomach, worked the buoy to death for the next hour with no love so the captain decided to head over to U buoy, thankfully he let me man the helm on the way over which almost instantly cured my seasickness, no luck at U buoy either so captain made the call to run the ledge on the way back to Kahana, no takers, back at the ramp my stomach was finally ready for cuzzo lights, ended the day with a proper celebration, many mahalos to Captain Jeff and first mate Sky for another great day at the blue office. Cheers – RM
So with the recent unveiling of the super lame hoverboard (maybe stupid is a better description) I felt inclined to share with you some real skateboarding on real skateboards. This video which showcases the spots just as much as the skaters is a throw back to classic 90′s street skating. Before it was infected by energy drink sponsorships and big box store logo placement, when skating was done in the street where it belongs not on some arena fantasy course. Having traveled to and skated most of the spots in the clip personally I can't help but have flashbacks of the good old days. If this video is a sign of the times the future looks bright for the next generation of classic street skateboarders. – RM
Some things never change and that's a good thing when you talking about Waimea Bay in the summertime. Sure the walk down to the beach is longer than most would like and parking and traffic are atrocious. But once you safely navigate through crowds of Military wives, California beach dudes and the Local rock bombers you are greeted by one of the best beaches on the island for sure. The water clarity in the summertime is A+ and trust me I'm a snob when it comes to water clarity and this place is one of my all time favs. Since fishing by boat is prohibited in the bay, there are actually a surprising amount of fish under water for your snorkeling pleasure. Anyways as you can see it was just another day in the paradise that we call home. Cheers – RM


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Videos tagged "threesixtykickflip"
The FLATGROUND CASE STUDY is a short film I made, starring Chad Tim Tim, that played at the Love & Guts art show in Costa Mesa, on August 5th. The idea was to create a non-linear story that didn't rely on a musical soundtrack. This way people could watch from any point within the film, for any amount of time. So at the exhibition, the video looped seamlessly throughout opening night. The film is an experiment in documenting style and technique, which was played back in a gallery setting (and now online) in a way that depicts the similarities of tricks through motion and style. Most of the video is presented in slow-mo, with the hopes that you can observe the shapes and technique through overlapping imagery… The basics of skateboarding, silhouetted and colored, come alive and create a moving Rorschach test. It was fun to come into this with a low-budget, creative way of thinking. The production process is simply Chad Tim Tim and myself, a white wall, two cameras, and a few lights, and then we edited it on Final Cut; no green screen or After Effects. Here's a link to the Vimeo channel I created, which has the full-length version, and also each individual segment. http://vimeo.com/channels/flatgroundcasestudy+ More details
What are Tags?
Tags are keywords that describe videos. For example, a video of your Hawaiian vacation might be tagged with "Hawaii," "beach," "surfing," and "sunburn."


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updated 05/29/2014 AT 9:00 AM ET
•originally published 05/29/2014 AT 10:10 AM ET
Prince George is already a superhero to many, and he's already got the pajamas to prove it – a set of Spider-Man nightwear, his mom Kate revealed Thursday.
But even the fast-growing prince isn't quite ready for them.
"She said George has Spider-Man pajamas, but they are too big for him just now. She was saying how much her little boy has grown so big, so quickly," a well-wisher, Lianne McNamara, told PEOPLE after meeting Kate in Scotland.
William and Kate are on their first official visit to the area of Strathearn, from which they derive their royal Scottish titles, the Earl and Countess of Strathearn.
Kate was a lady in red as she stepped out in a Jonathan Saunders coat over a dress by Goat. Joining William for a day out in Crieff, she accessorized the eye-catching scarlet outfit with a Celtic brooch that was a wedding gift.
It's their first outing as a couple since the tour of Australia and New Zealand.
At a local school, William, 31, was shown around an air ambulance amid speculation that he is considering flying one as part of a new career. "He was really keen to see how we work," said John Pritchard, lead paramedic on the helicopter. "I would certainly welcome him on to the team."


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This report is about horses. I wrote this for the people that work at pal o mine, I wrote this for my friend Brittney and I also wrote this for James Maslow from Big time rush .
Clipping is a handy way to collect important slides you want to go back to later.


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Gena is the mom of three boys, ages 6, 4, and feisty toddler. She is the wife of a great man, a Christian, blogger, and former kindergarten teacher turned stay-at-home mom. They live in the Dallas/ Ft. Worth, Texas area.
Latest posts by Gena (see all)
- Homemade Mini Caramel Apple Suckers – A Sweet Treat for Halloween! - October 1, 2015
- Taking Time to Listen To The Hippopotamus - September 29, 2015
- Seven Things You Should Do Before Getting Pregnant - September 28, 2015


text: welcome to watson mitchell, your letting specialist Watson Mitchell is the leading specialist lettings agent for Stamford and Bedford. As a residential property management company we are 100% committed to lettings. We have been providing landlords and tenants in Stamford and Bedford with an expert, specialist lettings service for more than 30 years. Fact: 99.8% of Watson Mitchell landlords categorise the service provided by Watson Mitchell Lettings Agency as "Excellent" Watson Mitchell Lettings Agency is a fully licensed member of ARLA and we place knowledge, honesty and the highest level of professionalism as key priorities. If you become a Watson Mitchell landlord or tenant in Bedford or Stamford, you can be assured that these priorities will be applied to all aspects of your let. Our fees are transparent, our client monies are held in bonded accounts for your protection, we undertake to exercise our duties to you quickly and efficiently and you are always assigned a named member of our staff who will deal with you throughout. In an industry where there are currently no qualifications required to practice as a lettings agent; landlords and tenants face a difficult task knowing who to trust. By instructing Watson Mitchell property management company, you are choosing a market leading specialist in Bedford and Stamford with more than 30 years' experience, knowledge and qualified staff. We would welcome the opportunity to discuss your letting and property management needs with you. latest news Check the small print - it could save your home It's THE worst-case scenario. A retired Navy Captain lost £56k due to inadequate insurance. It needn't have gone that far. ...more Heron Quay flat makes for a good buy-to-let Bedford delivers good buy to let returns but what makes a good property? ...more Our latest buy to let recommendations for Bedford Looking for a sound property investment? Here are our latest recommendations for Bedford ...more Remember, remember the 1st of October Watson Mitchell secures smoke alarm and CO detector deals to protect tenants and landlords ...more view all articles


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As the latest installment of AMC's zombie apocalypse, "The Walking Dead," airs on a recent Sunday night, Chris Hardwick calmly sits in a slightly tacky living room set in a small studio at CBS Television City. He silently reviews his notes on his iPhone and strategically positions his interview cards as the crew bustles around him and a (human) audience waits quietly in nearby bleachers.
The episode ends with a major character in dire straits - Andrea (Laurie Holden) is shackled and bound in a torture chamber devised by her ex-lover, the evil Governor (David Morrissey). As the final credits roll, the lights come up in the studio and Hardwick's somewhat incredulous expression is beamed live to the legions of "Walking Dead" viewers.
As the camera zooms in, Hardwick, wearing tennis shoes, a kaleidoscopic tie and a black jacket that looks a half-size too small, turns into "Dead" man, talking.
"Are you kidding me with that?" exclaims the 41-year-old comedian, host of AMC's surprise hit zombie chat-fest "The Talking Dead." "Andrea is being held captive in the chamber of horrors? What happens now?"
Broadcast directly after the phenomenally successful "The Walking Dead," "The Talking Dead" took on a life of its own this season, evolving from a half-hour companion show into a full-fledged, hour-long monster mash whose ratings in the coveted 18-49 demographic surpass a host of prime-time shows on the major networks.
Armed with an unabashed geek love for the series, Hardwick gleefully dissects every bite and slice from each episode while also juggling a panel of celebrity guests - all either associated with or just fans of the mother show. Led by Hardwick, who also hosts BBC America's cult favorite "The Nerdist," the panel dives into "Walking Dead" trivia, behind-the-scenes featurettes, and fields questions from viewers both in-studio and via email and phone calls.
"It's like a post-game show for the Super Bowl," said Brad Adgate, an analyst for New York-based ad firm Horizon Media. "This show has really capitalized on the power of social media. 'The Walking Dead' is one of the most popular shows on Twitter and Facebook, and this devoted following has always elevated 'The Talking Dead.'"
The March 24 episode of "The Talking Dead" averaged 4.5 million viewers, an increase of its weekly average of 3 million viewers. The midway point of the third season in February drew in 4.1 million viewers. Executives say about half of the audience for "The Walking Dead," which just concluded its third season, stays tuned for "The Talking Dead."
Joel Stillerman, AMC's head of original programming, said he thought "The Talking Dead" would find its audience when it launched in the second season, "but I would be lying if I said I thought we would get these kinds of numbers. To see how it's grown is really a testament to the show, and to Chris. There's just this incredible energy surrounding the show in social media."
Even more significantly, "The Talking Dead" is one of the least expensive series on AMC's prime-time slate - the set is spare, there's no band and the production is low-frills. While declining to say how much the show costs, Stillerman said "it's a good business model. We get a nice return on our investment."
The foundation of "The Talking Dead," of course, is conversation, which flows from a loose talk-show format. It isn't hard to book popular guests - in addition to Holden, other visitors include Robert Kirkman, who created the comic book series on which the show is based, and other writers, rocker Dave Navarro, writer-director Kevin Smith and comedian Patton Oswalt.
The only requirement for guests is that they be genuine fans of the graphic novel or the show - "The Talking Dead" is not the place for celebrities to hype their latest project. For instance, Aisha Tyler, who co-hosts the daily syndicated "The Talk" and is one of the voices on FX's animated comedy "Archer," did not mention those shows on her recent appearance (but Hardwick did plug her "Girl on Guy" pod cast).
Police: Woman charged with prostitution after sting at Salem spa
Fishers Island Oyster Farm raises oysters without impacting the environment
Old Lyme selectmen approve new benefits policy for first responders
First lady to be in Groton on Saturday for submarine christening
'Soup kitchen' could run out of operating funds by the end of the year
Newtown families' suit against gun maker sent to state court


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Busty teen Mason Moore loves to get gigantic facial shots
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Author has written 6 stories for Golden Sun.
12th Oct '12: Arghh, I got a dongle a few days ago and finally had internet at home - then Windows updated and it stopped working. Round my parents' place again tonight, though it's tough to get anything substantial done here. Gotta go into town and try to get it fixed tomorrow.
12th May '12: Fingers crossed, I should be able to get internet set up at my new place this spring.
Still been writing offline, split between ffnet fics and stuff for the anon meme on lj; might be able to get some of that up / finished soon, though my estimates of how long anything'll take seem to be wildly off (months and months, or just an all-nighter, or both and omg this is getting long?)
Btw, since they've stripped out the old homepage links, have a plaintext url:
Favourite pairings:
Golden Sun: Tons, though Dark Dawn didn't open up as many possibilities as it shut down. Valeshipping and Mudshipping are both kinda "sounds nice enough" to me, so I'm not too heartbroken by the canon. My personal headcanon is busy building up an eventual Alex/Felix/Isaac/Mia/Veriti/the Ice Queen group marriage... More realistically, I find most pairings or trios involving Isaac, Felix, Mia, Alex, Jenna, Sheba, Amiti, Rief or Eoleo pretty interesting.
Fire Emblem: The lack of Ilyana/Lucia in Radiant Dawn broke my heart. ;_; Ike/Soren, Ena/Rajaion and Tibarn/Reyson are pretty cool too. In FE7, Serra/Lucius looked like the shiniest, shippiest support, but Lucius turned out to be one of the few guys Serra can't hook up with in the epilogue. Go figure.
Tales of Symphonia: Colette/Zelos . They had that one skit where they bonded, coming down the mountain... It always seemed like there should have been more.
Skies of Arcadia: Fina/Aika/Vyse. Such an OT3.
FFVII: Aerith/Zack/Cloud/Sephiroth. And if anyone's seen any Scarlet/Tifa around, drop me a link? You'd have thought there'd be tons...


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Considers the ways in which Alfred Hitchcock adapted and transformed a variety of literary worksnovels, plays, and short storiesinto film. The adaptation of literary works to the screen has been the subject of increasing, and increasingly sophisticated, critical and scholarly attention in recent years, but most studies of the subject have continued to privilege literature over film by taking the literary sources as their starting point. Rather than examining the processes by which a particular author has been adapted into a diversity of films by different filmmakers, the contributors in Hitchcock at the Source consider the processes by which a varied range of literary sources have been transformed by one filmmaker into an impressive body of work. Throughout his career, Alfred Hitchcock transformed a variety of literary sourcesnovels, plays, short storiesinto what is arguably the most coherent and distinctive (narratively, stylistically, and thematically) of all directorial oeuvres. After an introduction surveying the nature and diversity of Hitchcocks sources and locating the current volume in the context of theoretical work on adaptation, nineteen original essays range across the entirety of Hitchcocks career, from the silent period through to the 1970s. In addition to addressing the process of adaptation in particular films in terms of plot and character, the contributors also consider less obvious matters of tone, technique, and ideology; Hitchcocks manipulation of the conventions of literary and dramatic genres such as spy fiction and romantic comedy; and more general problems, such as Hitchcocks shift from plays to novels as his major sources in the course of the 1930s. The complexity and sweep of this book are staggering; this is a one-stop source for information on the literary origins of Hitchcocks works. This is a one-of-a-kind text, which fills a real niche in both film and Hitchcock studies. Wheeler Winston Dixon, James Ryan Professor of Film Studies, University of Nebraska at Lincoln The book is replete with fresh insights into particular films and source texts, fresh approaches to the work of a hugely important and influential screen artist, and fresh evidence for the value of adaptation studies. David Sterritt, author of The Films of Alfred Hitchcock
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Character of the Morumbidgee where it issues from the hilly country-- Appearance of approach to swamps--Hamilton Plains--Intercourse with the natives--Their appearance, customs, &c.--Change in the character of the river--Mirage-- Dreariness of the country--Ride towards the Lachlan river --Two boats built and launched on the Morumbidgee; and the drays, with part of the men sent back to Goulburn Plains.
Embarkation of the party in the boats, and voyage down the Morumbidgee-- The skiff swamped by striking on a sunken tree--Recovery of boat and its loading--Region of reeds--Dangers of the navigation--Contraction of the channel--Reach the junction of a large river--Intercourse with the natives on its banks--Character of the country below the junction of the rivers-- Descent of a dangerous rapid--Warlike demonstrations of a tribe of natives--Unexpected deliverance from a conflict wi
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Shannon Lush's cheap and cheerful Christmas pudding - yarm!...Monday 14 December 2009
Judy Davie, The Food Coach: If you don't have enough mouths to feed for a whole turkey you can all enjoy this simple and delicious roast chicken with apricot and pistachio stuffing. iraost oThis beautiful stuffing is a celebration of all things good and makes the simplest of meals an absolute feast. ...Tuesday 1 December 2009
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