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Attend the annual Colloquium and Ecumenical Lecture
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Players looking to improve their game and showcase their talents are encouraged to register.
Sr. Jane Mary Sorosiak Lecture features master photographer Eric Eggly
Recognizing the contributions of women artists, visionaries and entrepreneurs
Buffet sponsored by the Office of Diversity and Multicultural Services
A Nun's Life Ministry's Motherhouse Road Trip comes to Sylvania.
Lourdes Drama Society presents "Just Desserts."
New center offers state-of-the-art classrooms and studios for art and music courses, graduate school offices and additional space for the Sophia Center.
Historian D. Scott Hartwig to present "To Antietam Creek: The Maryland Campaign of 1862."
Annual Black History Month Celebration features ALMA Drum and Dance Ensemble.
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Pięknie mroźnie . Pozdrawiam
Thank you Petr! I am glad you like it. Syl
Super foto like salut
Impressively, perfectly! L&YS With pleasure we invite you in group.
Arches in Nature Sincerely, Vasiliy from Siberia
Beautiful picture. I would love to take a cruise to Bora Bora. Thanks Mabut
Piękny obraz z widokiem na Szczecin.
...<FL>...Pozdrawiam z Szczecina.Elka
Vay bee
It is very nice ! Like
Bardzo ładny kadr. Pozdrawiam. Ryszard
Hi, Linda Forrester
stunning capture and nice composition L&F
thank you very much for your visit to my gallery
best regard Tiffany Liem

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Posts filed under "Consumer Spending"
People balk at being controlled. Once you place limits, the public abandons you or finds a way to circumvent what you are doing. Give people the opportunity to do more, to expand their horizons, to share. Once you tell them what they cannot do, you're screwed.
This is why no free tier music services will not dominate in the short run. The public has options. Whether it be YouTube or piracy. Trying to convince people that stealing is immoral doesn't work, the RIAA already tried that. Don't demonize your customers, EMBRACE THEM!
When it's all said and done there's going to be a ton of dough in recorded music. But the rights holders are doing their best to forestall this result. They believe competition is key, not understanding that online one service dominates and the rest carve up tiny slices. You want to have one service win. Otherwise, there's customer confusion. No one wants to embrace what everybody else does not. That's the lesson of the Tower of Babel society. Nitwits speak about a long tail, human beings want to belong, feel connected, they don't want to be down in the niche alone, but together, with everybody else. Which is why there is only one Facebook, one is enough, you don't want to build your digital home in multiple locations. And you want a good chance of being seen. Balkanization is death.
That's positively brick and mortar. The labels gave exclusives to Best Buy, indie retailers screamed, but it's the indie retailers who remain. You think you're getting a leg up by offering exclusives. You're just pissing people off.
We live in a nation of vast income inequality. We don't want to hear winners complain. Ever. And we don't want to hear how a product benefits you, but how it benefits US!
Word of mouth built Google, Facebook and Amazon. In a world where it's impossible to reach everybody via marketing, your only hope is you gain users and have them spread the word. People will listen to their friends, they ignore advertising. The key is to build something so cool, so utilitarian, that others will spread the word. And when you do publicity, it's about explaining the growth. You don't LEAD with the publicity, you FOLLOW with it.
This is about to whipsaw the music industry, which believes in frontloading. But no one can garner enough streams in the first week to make their numbers. The key is to get people to stream for years. How do you tell the story then? Awareness is important, but it's all about the sustained build and the story. And the story isn't who you worked with and what TV outlets you're appearing on, but how people have embraced the tunes.
They believe it's their god-given right to check something out for free. And they eventually pay, but way down the line, because of CONVENIENCE!
The mobile industry did not force everybody to give up their flip phones for smartphones. Rather, users adopted them and convinced others to get them. And then everybody signed up for a data plan so they could play!
Mobile didn't eliminate the flip phone, it came up with something better. And you had to pay, handsomely, to get one and play. And you could not play without one, there was no free tier/competition.
However, people ARE cheap. Which is why T-Mobile and wi-fi calling are making inroads. Tell someone all day long that Verizon has a larger LTE footprint and they don't care, they focus on price. Proving that some people will pay for quality, the others have to gradually get there. Kind of like cable television. There were early adopters, then everybody else came aboard and cable raised the price.
Once everybody subscribes to a music service, then you can raise the price, as did SiriusXM.
The convenience may come via bundling, i.e. with a cable or cell phone contract, or it may be about functionality, but that's what closes users.
Right now, Spotify has learned that giving mobile away for free creates new subscribers. Don't ignore the data. Your intellect is not always right. This is one thing tech understands and the entertainment business does not. When you're talking about the internet, ignore your gut and go with the data.
The truth is there to be found online. And sure, some might not Google it, but once someone does, the word spreads like wildfire. Jay Z says Tidal pays more. There is no evidence of this and it is contrary to the standard label contract. This is blowback just waiting to happen.
No one person is as strong as a service. Evan Spiegel could kill someone, but it would not kill Snapchat. Taylor Swift cannot kill Spotify. Once something reaches critical mass the only way it dies is if the service itself screws up or something superior appears and supersedes it. Never yell about behavior, never complain, create something better, ahead of the marketplace, that will draw people to it.
We're not going back to dialup and we're not going back to flip phones. Never base your play on taking something away, that's never ever gonna work. You always want to deliver MORE!
Most people don't even know the "New York Times" has a soft paywall. Because they don't care enough about the "Times." Then again, Facebook users far exceed subscribers to the "Times." If your service can sustain on the payment of a few, create a paywall. If you want everybody, start free and figure out a way to add desirable features and functionality to get those people to pay.
Furthermore, value can be unlocked in unforeseeable ways. The aforementioned Snapchat was a free messaging service, now it's an entertainment hub. Create mass, then evaluate opportunities and pivot. If you don't think audience size is key, you were never in a rock and roll band. Audience is everything. It will follow you and support you as long as you respect it and treat it right.
Especially with net neutrality. The public believes it OWNS the internet. Forget the truth, the backbone, the last mile. They see it as a democratic village where they have a voice. Impinge upon this at your peril.
It's a fine line between privacy and data collection, but the truth is what you learn about user behavior has incredible value. Once again, this only comes from mass.
Amazon is inert. Artists live and breathe. Artists are separate from services. Artists have an identity. Artists don't just accept, they question. Tie yourself up with a service at your peril. The service functions 24/7, you don't come to bat that often. If you're seen as a tool, even of a good service, it will come back to haunt you. Don't always say yes, artists gain traction by saying no.
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If you would like to subscribe to the LefsetzLetter
Category: Consumer Spending, Corporate Management, Web/Tech
47% of households have a 0% personal savings rate, see chart below. Source: Torsten Sløk, Ph.D., Deutsche Bank Securities
Category: Consumer Spending, Investing, Really, really bad calls, Wages & Income
Source: WonkBlog
Category: Consumer Spending, Technology
Click for complete infographic
Category: Consumer Spending, Digital Media, Retail, Technology, Web/Tech
Category: Consumer Spending, Economy, Think Tank
I am having lunch today with Jonathan Miller of Miller Samuel, and that means the latest (and some of the craziest) NYC real estate updates. In honor of this meal, have a look at the long term trend in home sizes in the US: Source: Treehugger
Category: Consumer Spending, Real Estate
Source: Business Insider
Category: Consumer Spending, Digital Media, Technology
@TBPInvictus I'm excited about skiplagged.com, the website that is currently being sued by United Airlines and Orbitz for enabling "hidden city ticketing" (which you should read up on before continuing). I needed to travel to Cincinnati last spring. During a period in which my plans were tentative, round-trip fares were in the mid-$300 range or…Read More
Category: Consumer Spending, Current Affairs, Really, really bad calls, Travel, Web/Tech
Thanksgiving is behind us, and we are in full Shopmas mode. By now, you should have already made up your list of who has been naughty — overcharging for subpar performance — and who has been nice (those rare alpha-generators). Reward them accordingly. Let your favorite 2&20-er know exactly how much you appreciate their work with…Read More
Category: Consumer Spending, Hedge Funds, Humor
Stories based on Black Friday consumer spending numbers are a holiday tradition. Bob talks with investor and Bloomberg View contributor Barry Ritholtz about the problems with stories based on those numbers. NPR/WNYC: Source: On the Media
Category: Bad Math, Consumer Spending, Data Analysis, Really, really bad calls


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Jan 11
"The Cross Factor Live Show" Debut Guest Psalmist
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Tune in for LIVE INTERVIEW with Host: Diandra Smith-Hall on the SpiritSoul Radio Network (SPSN)
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National Adoption Awareness Benefit Concert presented by "We Are M.U.S.I.C.: Ministering Unified Song In Christ"
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International Women of Standard Conference 2013 "Positioned for Purpose"
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Label: Independent
Manager: Chameleon Productions, LLC/ Stage 2 Media Group
Bio: PATRICIA LEIGH is a singer and songwriter who has come to the gospel scene presenting lyrics that speak to the hearts of many. Her voice is colored with warm and soulful tones making for a pleasurable listening experience for all to enjoy. Her songs of good news reveal a positive message that are...See Full Bio


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Buy properties in Ringwood Road, Parkstone, Poole BH14 - 2 bedrooms
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Felton Road, Poole BH14Flat for sale - 2 bedrooms
Modern and spacious apartment with a large lounge/diner, share of freehold and garage. Situated in a Cul-de-sac in sought after lower parkstone. This property has excellent access to transport links, local schools and colleges. To book a viewing call ... More details
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Marketed by Fox & Sons, BH15. Call 01202 618170


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Round the bases this fall with softball or kickball at great locations all over Chicago, then head to your favorite Players bar for food & drink specials! Good luck this season!
Fall registration is now open for sports including flag football, softball, kickball, bubble soccer & more! Grab your team and register today before leagues fill up! details
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We're Newcastle fans like you. If you're a fan, The Unofficial Magpies App gives you live scores for all teams in the league, team news, fixture, standings, soundboard, club tweets and more! Whatever you call your football team (the Barcode, the Toon), this is the app for you!
from 9 reviews


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hello PA mtbrs,
i will be visiting your mountainous state next weekend for a wedding in conneaut lake. i was hoping to ride some sweet singletrack on sunday july 8th before heading back to the det-313.
any suggestions on where to ride that:
A. is worth checking out
B. is marked well enough that i won't get totally lost
thanks for any suggestions you have.
dana (a velobella from MI)
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Page 1
Multicellular dynamics during epithelial elongation
Jennifer A. Zallen1 and J. Todd Blankenship
Developmental Biology Program, Sloan-Kettering Institute, 1275 York Avenue Box 266, New York,
The reorganization of multicellular populations to produce an elongated tissue structure is a
conserved mechanism for shaping the body axis and several organ systems. In the Drosophila
germband epithelium, this process is accompanied by the formation of a planar polarized network
of junctional and cytoskeletal proteins in response to striped patterns of gene expression. Actomyosin
cables and adherens junctions are dynamically remodeled during intercalation, providing the basis
for polarized cell behavior. Quantitative analysis of cell behavior in living embryos reveals
unexpected cell population dynamics that include the formation of multicellular rosette structures as
well as local neighbor exchange.
A basic mechanism for generating three-dimensional structure during development is the
elongation of multicellular tissues by intercalation, the polarized movements of cells
perpendicular to the direction of elongation. Cell intercalation in mesenchymal tissues plays a
major role in shaping the body axis in Xenopus and zebrafish [1–4], and intercalation in
epithelial tissues drives the elongation of the Drosophila germband [5], the ascidian notochord
[6], the chick primitive streak [7] and organ systems such as the gut, lung, spinal cord and inner
ear [8–12]. The outcome of intercalation is similar in mesenchymal and epithelial tissues, but
the underlying cell behaviors appear to be different. Intercalating mesenchymal cells in
zebrafish and Xenopus elongate in the direction of cell movement and extend polarized
protrusions that support short- and long-range cell migrations [13–15]. By contrast, epithelial
cells in the Drosophila germband are proposed to intercalate through the spatially regulated
assembly and disassembly of intercellular adherens junctions [16]. Consistent with this
possibility, several proteins required for intercalation are associated with the adherens
junctions, including cytoskeletal and junctional components that may directly influence the
tenacity or transience of cell contacts within the sheet [16–18]. This review will focus on
epithelial intercalation in the Drosophila germband, with an emphasis on the mechanisms that
establish polarity within cells and the cell behaviors that translate these polarities into tissue
1Corresponding author: Jennifer A. Zallen, phone: 212-639-8937, fax: 212-717-3623, e-mail: E-mail: firstname.lastname@example.com.
Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers
we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting
proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could
affect the content, and all legal disclaimers that apply to the journal pertain.
NIH Public Access
Author Manuscript
Semin Cell Dev Biol. Author manuscript; available in PMC 2009 June 22.
Published in final edited form as:
Semin Cell Dev Biol. 2008 June ; 19(3): 263–270. doi:10.1016/j.semcdb.2008.01.005.
NIH-PA Author Manuscript
NIH-PA Author Manuscript
NIH-PA Author Manuscript
Page 2
Two models for axis elongation in Drosophila: differential adhesion and
planar polarity
During body axis formation in the Drosophila embryo, the germband epithelium increases 2.5-
fold in length along the head-to-tail (anterior-posterior) axis and narrows in width along the
back-to-front (dorsal-ventral) axis to create the basic layout of the body plan [5,19]. This
morphogenetic process is completed in less than two hours, with most of the elongation taking
place in the first 30–40 minutes through cell rearrangements that occur largely in the absence
of cell division [5]. During intercalation, germband epithelial cells interpose themselves
between their dorsal or ventral neighbors, resulting in a decrease in the number of cells along
the dorsal-ventral (DV) axis and an increase in the number of cells along the anterior-posterior
(AP) axis (Figure 1A,B). These oriented movements –perpendicular to the direction of tissue
elongation – allow relatively short-range changes in cell position to produce a major change
in tissue shape.
The spatial information that guides cell behavior during axis elongation in Drosophila is
provided locally by interactions between neighboring cells, rather than by a distant polarizing
signal. The local nature of these cues was first suggested by experiments demonstrating that
interfering with tissue specification dorsal, ventral, or posterior to the germband does not
disrupt intercalation [5]. Instead, patterning information within the germband epithelium itself
is required for its elongation. The Even-skipped (Eve) and Runt transcription factors are
initially expressed in seven stripes along the AP axis through the action of a global patterning
system that subdivides the embryo into segments [20,21]. In addition to their intrinsic role in
cell fate, the Eve and Runt stripes also influence interactions between cells that bias the
direction of cell movement. Disruption of these stripes in embryos in which Eve or Runt are
absent or uniformly misexpressed causes a substantial reduction in elongation [5,17], and an
ectopic source of either protein is sufficient to reorient the axis of cell polarity [17]. A related
mechanism operates in Xenopus, in which cells from the developing notochord intercalate
when explants from anterior and posterior regions are combined in culture, but not when the
explants are from the same region [22]. These results suggest that intercalary behavior is guided
locally by signaling events at boundaries between cells with different identities. The molecular
nature of these signals is unknown.
How do striped patterns of spatial information determine the direction of cell movement? In
one model, Eve and Runt expression could confer differential adhesion between adjacent
stripes of cells [5,23]. Quantitative or qualitative differences in adhesion can account for the
tissue-specific aggregation of dissociated cells [24] and patterns of cell sorting in culture
[25]. In addition, in vivo evidence supports a role for differential adhesion in a range of
developmental processes including oocyte positioning, tissue separation, and compartmental
boundary formation [26–28]. In the Drosophila germband, adhesive differences present in a
striped configuration could trigger tissue elongation if cells rearrange to maximize contact with
cells of the same stripe and minimize contact between stripes (Figure 1C) [5,23]. While blocks
of similarly adhesive cells the width of a typical Eve or Runt stripe are in principle sufficient
for elongation [5], a finer pattern of adhesive differences created by the combinatorial action
of multiple striped genes is more compatible with the observation that intercalary behavior
occurs throughout the germband, not just near stripe boundaries [23].
An alternative model postulates that different domains within a single cell – rather than absolute
differences between cells – provides the driving force for intercalation. In this planar
polarization model, each cell could acquire a polarized architecture that is asymmetric with
respect to the AP and DV axes of the embryo (Figure 1D). Intercalating cells in this model rely
on striped spatial cues not to determine their adhesive properties, but to generate and orient
intrinsic cellular asymmetries. For example, specific proteins may be targeted to interfaces
Zallen and Blankenship Page 2
Semin Cell Dev Biol. Author manuscript; available in PMC 2009 June 22.
NIH-PA Author Manuscript
NIH-PA Author Manuscript
NIH-PA Author Manuscript
Page 3
between neighboring cells along the AP axis (AP interfaces) that encounter recognizable
differences in Eve and Runt expression. Several epithelial tissues display molecular planar
polarity, including the Drosophila wing, eye, and notum and the mammalian cochlear
epithelium. In these cases, polarized proteins are components of a conserved planar cell polarity
(PCP) signaling pathway mediated by the Frizzled receptor [29–31]. Some components of this
pathway are dispensable for germband extension [17], but a distinct set of cytoskeletal and
adherens junction proteins is planar polarized in the Drosophila embryo [16–18]. These
findings support a role for a planar polarization mechanism in elongation of the Drosophila
body axis.
Establishing cellular asymmetry along planar axes
To distinguish between different mechanisms for intercalary behavior, it is necessary to
identify proteins essential for this process that have spatially specific patterns of expression or
subcellular localization. In particular, intercalating cells in the Drosophila germband display
a planar polarized distribution of cytoskeletal and adherens junction proteins (Figure 2). The
homophilic adhesion molecule E-cadherin, its associated cytoplasmic protein Armadillo/β-
catenin, and the Bazooka/PAR-3 PDZ-domain protein are concentrated in interfaces between
dorsal and ventral neighbors (DV interfaces) [17,18]. Conversely, filamentous actin (F-actin)
and the actin-based myosin II motor protein are enriched in the reciprocal AP interfaces [16–
18]. These polarities are specific to intercalating cells, appear just before the onset of cell
movement, and require the AP patterning system that is essential for axis elongation [17,18].
Consistent with a functional role for these planar polarized proteins, axis elongation is reduced
in embryos that are defective for the myosin II heavy or regulatory light chain subunits and
embryos injected with an inhibitor of the Rho kinase myosin activator [16], as well as embryos
that are defective for Bazooka or its binding partners, the Par6 PDZ-domain protein or atypical
protein kinase C (aPKC) [17,18]. A related system of planar polarity may extend to other
organisms, as Xenopus homologs of Par6 and aPKC are enriched in a planar polarized fashion
in intercalating notochord cells [32].
Planar polarized junctional and cytoskeletal structures in the Drosophila embryo precedes
intercalation and are likely to drive the separation of anterior and posterior cells and the
formation of contacts between dorsal and ventral cells (Figure 3A–C) [16–18]. The functional
relationships between different aspects of polarity are not clear, although F-actin is the first
protein to localize asymmetrically in the plane of the tissue and adherens junction polarity is
not detected until a later stage (Figure 2C) [18]. Bazooka is required for the apical localization
of adherens junction proteins [33, 34] and can bind to Armadillo/β-catenin [35], suggesting
that Bazooka may directly stabilize junctions at DV interfaces. Actomyosin contractility can
also influence adhesion, although evidence from the literature is contradictory on this point.
In some cell types myosin II promotes the disassembly of adherens junctions [36, 37],
consistent with the reciprocal distributions of myosin II and E-cadherin in the Drosophila
germband [18]. However, in other cell types myosin II enhances adhesion through the lateral
clustering of E-cadherin molecules [38] or spatially localized contractility at the periphery of
growing contacts [39]. Cells from myosin heavy chain II-A knockout mice display reduced
adhesion and less surface E-cadherin [40], indicating that some myosin II activity is necessary
for adhesion. However, higher levels of myosin II or the spatial distribution of contractile forces
in the cell may determine whether myosin II supports or opposes the stabilization of junctional
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Cell polarization through extracellular signals and intracellular self-
The polarized architecture of intercalating cells could be generated by the self-organization of
distinct cellular domains in response to a single polarizing cue or landmark. Alternatively,
different regions of the cell could be specified independently in response to multiple
extracellular inputs. The establishment of planar polarity in the Drosophila embryo is not yet
understood, but other systems provide instructive examples of intrinsic and extrinsic cellular
mechanisms that could contribute to this process.
Cellular self-organization can be achieved through a variety of molecular mechanisms,
including inhibitory phosphorylation events displacing kinase from substrate [41–43],
competitive interactions between mutually exclusive protein complexes [29–31], and
actomyosin-dependent transport of proteins within the cell [44–46]. A well-characterized
example of cellular self-organization is anterior-posterior axis formation in the C. elegans
embryo, which occurs at the one-cell stage. A single polarizing event mediated by sperm entry
determines the posterior pole of the cell [47] and leads to the anterior accumulation of PAR-3
(Bazooka), PAR-6, and PKC-3 (aPKC) and the posterior accumulation of the PAR-1 serine/
threonine kinase and the PAR-2 RING domain protein [44–46]. These molecularly distinct
cortical domains are generated by an actomyosin-dependent flow that initiates at the site of
sperm entry and reorganizes the entire cell cortex and cytoplasm [48]. The signals that trigger
this directional flow emanate from the sperm centrosome [49] as well as the localized
deposition of CYK-4 RhoGAP and downregulation of ECT-2 RhoGEF at the posterior pole
of the embryo [50–52]. These events lead to inactivation of the RHO-1 GTPase at the posterior
pole and a displacement of the cortical actomyosin network toward the anterior of the embryo.
Actomyosin-dependent cortical flow colocalizes with and is required for the delivery of PAR-3,
PAR-6, and PKC-3 to the anterior cortex [48,53–56]. Conversely, feedback from the anterior
PAR-3 protein is required to sustain this cortical flow [48,57,58]. Therefore, a network of
molecular interactions leads to the autonomous organization of both anterior and posterior
cellular domains in the C. elegans embryo.
An alternative mechanism for polarization is available to cells in multicellular tissues, which
are exposed to a range of environmental inputs that could specify distinct aspects of planar
polarity. Consistent with this possibility, intercalating cells in the Xenopus embryo integrate
signals from multiple sources. Polarized protrusions in the developing notochord are restricted
to a two-dimensional plane by the extracellular matrix [59] and these protrusions are locally
inhibited at the notochord boundary [60]. Moreover, Xenopus neural plate cells convert from
bipolar to a directional unipolar motility in response to contact with the underlying mesoderm
[15] and exposure to a diffusible signal from the midline [61]. In support of a multi-signal
polarization mechanism in Drosophila, some properties of planar polarity appear to be
separable in the germband epithelium. An actomyosin network is still enriched at AP interfaces
in Par6 and aPKC mutants, despite the fact that large areas of DV interfaces are vacated by
Bazooka [18]. Mislocalized Bazooka aggregates also retain their affinity for DV interfaces in
basolateral regions, whereas myosin II remains concentrated apically [18,62]. These findings
suggest that different properties of planar polarity can be regulated independently in Par6 and
aPKC mutant backgrounds.
The independent modulation of distinct aspects of cell polarity by extracellular signals could
provide a flexible mechanism for maintaining planar polarity in a dynamic and disordered
cellular environment. Germband cells display a wide range of topologies [18,63], and the
organization of a four-sided cell is likely to be very different from that of a six- or seven-sided
cell, presenting a challenge to self-organizing strategies in which polarity is organized around
a single landmark. Moreover, intercalating cells have to continually remodel their polarity
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through multiple rounds of cell rearrangement. An externally-driven cell polarization could
provide a mechanism to regenerate asymmetry in moving cells that transition between different
structural states.
Cytoskeletal and junctional dynamics during intercalation
The planar polarized distribution of junctional and cytoskeletal proteins in the Drosophila
embryo is consistent with a model in which increased contractility and decreased adhesion at
AP interfaces leads to the disassembly of contact between anterior and posterior cells during
intercalation [16,18]. Little is known, however, about how these lost contacts are replaced by
new contacts between dorsal and ventral cells to produce directional cell rearrangement. One
possibility is that a rapid reloading of myosin II could cause AP interfaces to shrink whenever
they attempt to reform [16]. Alternatively, increased adhesion at DV interfaces could facilitate
cell rearrangement by favoring new contacts between dorsal and ventral cells [17,18].
However, the association of Bazooka, which is thought to stabilize adherens junctions, is not
detected until several minutes after the establishment of contact between cells [18], suggesting
that Bazooka may not affect the formation of cell contacts but may instead act to stabilize them
once they form.
The actin cytoskeleton can act as a positive or negative regulator of junctional stability and
could therefore influence the formation and elimination of cell contacts during intercalation.
Actin filaments in the Drosophila germband not only assemble a contractile actomyosin
network at shrinking interfaces, but are also present as a transient burst at growing interfaces
[18]. The establishment of contact between epithelial cells in culture is also accompanied by
cytoskeletal reorganization, including the formation of actin-rich lamellipodia and the localized
recruitment of the Rac1 GTPase, the actin-nucleating formin-1 and Arp2/3 complex proteins,
the Arp2/3 activators N-WASP and cortactin, and VASP [64–66]. Sites of actin polymerization
dynamically redistribute to the expanding periphery of growing interfaces and are replaced by
a central zone of adherens junctions [39]. By analogy, a noncontractile, polymerizing actin
structure could drive the formation and growth of new contacts between cells in the
Drosophila germband. Mutually exclusive contractile and polymerization-driven cytoskeletal
structures could provide a mechanism to ensure the directionality of cell rearrangement. For
example, the disassembly of actomyosin cables could render adjacent anterior and posterior
cells temporarily refractory to actin polymerization, favoring the actin-dependent stabilization
new junctions between dorsal and ventral cells.
Local interactions and global cell population dynamics during intercalation
An understanding of the global patterns of behavior that arise from local interactions between
cells requires the quantitative analysis of cell population dynamics. The number of neighbors
that a cell is in contact with, via a shared interface, is a useful measure of cell topology [63,
67–69]. The distribution of polygon classes provides a statistical measurement of cell
interactions. Epithelial sheets are often presumed to consist predominantly of hexagonal cells,
but it is becoming apparent that many tissues diverge significantly from this pattern [18,63,
68,69]. The germband epithelium contains a substantial fraction of nonhexagonal cells before
intercalation (~35%), and this fraction nearly doubles during intercalation [18,63]. Topological
diversity (or disorder) is a signature of intercalating populations that increases as the germband
elongates [18,63]. Therefore, rather than describing intercalating populations in terms of
uniform behaviors, may be more appropriate to view them as a collection of cells with similar
tendencies that behave differently under different topological and geometric constraints.
The germband epithelium maintains its integrity throughout axis elongation and the
disassembly of contacts between some neighboring cells is balanced by the acquisition of
contacts between new neighbors. Elementary neighbor exchange events are overwhelmingly
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text:
Release Date:
September 1, 1992
This 16-song collection is more a survey of sunshine pop than actual psychedelia, and is mostly valuable for gathering together a lot of singles by acts who otherwise either weren't too well represented on CD in 1992, or aren't the type of acts from whom most listeners would want more than a song or two in their collections -- for every top-flight pop/rock act like the Hollies ("King Midas in Reverse"), the 5th Dimension ("Up, Up and Away"), the Association ("Windy"), Spanky Our Gang ("Lazy Day"), the Rascals ("Groovin'"), the Box Tops ("Neon Rainbow"), and Harpers Bizarre ("The 59th Street Bridge Song"), there are performers like Scott McKenzie ("San Francisco"), the Cowsills ("The Rain, the Park and Other Things"), future actress Marcia Strassman ("The Flower Children"), the Love Generation, Parade ("Sunshine Girl"), and a brace of similar acts, who had their moment of laid-back Summer of Love-inspired cool and disappeared from radar screens. The melodies flow freely and generally lyrically and occasionally languidly -- the only complaint is that some of the music goes a bit far astray from the mood and period that they're trying to capture; in place of "Lazy Day," "Like to Get to Know You" might've been a better choice from the repertoire of Spanky Our Gang, and perhaps a slightly punkier edge -- courtesy of, say, Paul Revere the Raiders -- might've been better than some of the really ubiquitous tracks like "Groovin'" by the Rascals. The notes are reasonably thorough and the sound is excellent. Bruce Eder, Rovi
- Genre: R&B, Rock
- Subgenre: Psychedelic/Garage, British Invasion, Folk/Country Rock, Pop/Rock, R&B/Soul, Rock & Roll/Roots
- Category Pop-Soul, Rock & Roll, Baroque Pop, British Invasion, Blue-Eyed Soul, Soul, Psychedelic, Folk-Rock, Sunshine Pop
- Artist: Various Artists
- Additional Artist: Various artists collection
1.StopSan Francisco (Be Sure to Wear Flowers in Your Hair) 3
2.StopReach Out of the Darkness 3.19
3.StopGet Together 4.41
4.StopThe Flower Children 3.09
5.StopLove Is All Around 3.02
6.StopGroovin' 2.3
7.StopThe Rain, the Park & Other Things 3.01
8.StopUp, Up and Away 2.4
9.StopWindy 2.56
10.StopLazy Day 3.07
11.StopThe 59th Street Bridge Song (Feelin' Groovy) 2.36
12.StopGroovy Summertime 2.24
13.StopSunshine Girl [*] 2.45
14.StopNeon Rainbow [*] 2.56
15.StopKing Midas in Reverse [*] 3.1
16.StopSan Franciscan Nights [*] 3.23
other Info.
- Online Item #: 12023044
- Store Item Number (DPCI): 244-14-6867
- Made in the USA or Imported


text:
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Religious Architecture: Anthropological Perspectivesby Verkaaik, Oskar
Univ of Chicago Pr
Questions About This Book?
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This is the edition with a publication date of 2/15/2014.
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- The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any CDs, lab manuals, study guides, etc.


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DEFINITION of 'SEC Form PRE 14A'
A filing with the Securities and Exchange Commission (SEC) that must be filed by or on behalf of a registrant when a shareholder vote is required on an issue not related to a contested matter or merger/acquisition. SEC Form PRE 14A should provide security holders with sufficient information to allow them to make an informed vote at an upcoming security holders' meeting or to authorize a proxy to vote on their behalf. It includes information about: the date, time and place of the meeting of security holders; revocability of proxy; dissenter's right of appraisal; persons making the solicitation; direct or indirect interest of certain persons in matters to be acted upon; modification or exchange of securities; financial statements; voting procedures; other details.
BREAKING DOWN 'SEC Form PRE 14A'
Form PRE 14A, which is also known as "preliminary proxy statement not related to a contested matter or merger/acquisition", is required under Section 14(a) of the Securities Exchange Act of 1934. This form is filed with the SEC when a preliminary proxy statement is given to shareholders and helps the SEC ensure that shareholders' rights are upheld.
SecurityA financial instrument that represents an ownership position ...
AcquisitionA corporate action in which a company buys most, if not all, ...
SEC Form PRES14AA now-obsolete filing with the Securities and Exchange Commission ...
Securities And Exchange Commission ...A government commission created by Congress to regulate the securities ...
Proxy1. An agent legally authorized to act on behalf of another party. ...
MergerThe combining of two or more companies, generally by offering ...
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Explaining the 10-KA 10-K is an annual comprehensive report that thoroughly recaps a company's performance.
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text:
|By Yakov Fain
Article Rating:
|February 20, 2013 10:40 AM EST
Disclamer: I'm not a PHP developer, and have no intention to become one.
I just needed a simple script that would echo the data it received. Writing such a script is not a rocket science, but now I need a Web server that would support PHP, which means pretty much any server other than the toy one that comes with Aptana.
OK, I've installed the XAMPP package that includes Apache Web Server and supports PHP. It comes with a nice little UI with the buttons to start stuff. It's shown on the right and can turn on/off Apache, MySQL, and FTP with a click of a button, which is perfect solution for everyone, but me. Remember, I want to do it from Aptana, and not from and external UI panel. But first things first, let me check that my PHP script even works under Apache.
But the fact that I had to leave Aptana bothered me and I decided to configure an external Web server in this IDE. I did similar thing in Eclipse and Apache Tomcat a million times, but this is different – I needed to start a prepackaged Apache Web server from XAMPP.
First, I learned how to do this from a command line in the Terminal Window (I use MAC OS):
To start apache do this: sudo /Applications/XAMPP/xamppfiles/xampp startapache
To stop apache do that: sudo /Applications/XAMPP/xamppfiles/xampp stopapache
But I knew it wouldn't be that easy to do from the IDE, casu when I do stuff as a sudo user, I get a command line prompt to enter the admin's password. OK, let's try and see what happens. Right-click on the Aptana's project, then Run Configurations, then the link Configure next to the "Use selected server". Then I've entered everything about my Apache Web server:
Aptana has created the Servers view with this server entry, but when I tried to start the server by clicking on the green play button it gave me this error: "no tty present and no askpass program specified". I knew it! Aptana doesn't know where to ask for the sudo's password!
How can I turn this stupid password off? Google helped – there is a system file /etc/sudoers that has to be edited to allow certain users to sudo without being bothered with the password. Can't edit it – not enough permissions. That's an easy one. The unix command chmod works fie on Mac. Being a lazy person I did sudo chmod 777 sudoers. It did the job, but it was a mistake – stay tuned. Opened the file, figured out that I need to uncomment one line and specify my ID with the NOPASSWD option.
OK, but the warning in this file reads "# This file MUST be edited with the 'visudo' command as root. Failure to use 'visudo' may result in syntax or file permission errors that prevent sudo from running." Uuuh, getting dangerous, nice! I still remember a couple of vi commands – did the editing in the Terminal window, saved the file… and got the error message that the "/etc/sudoers is mode 0777, should be 0440 ". Man, that was my laziness with chmod 777. Let me change it to 440. Not that easy now! It doesn't allo me to change the permissions back. Am I screwed or what? Did a backup to my external disk last week – shouldn't be difficult to recover the original file sudoers.
But let me google first – it helped again – was there a life before Google? Some kind soul suggested to run Disk Utility, which has a button "Repair Disk Permissions". It repaired a bunch of files including this one keeping my corrections intact.
Voila! Now I can start my Apache Web Server without leaving Aptana IDE by clicking on the Play button in the Servers view! Great! But how to stop it? Eclipse IDE has a red little square next to Play? The right-click menu doesn't exist in the Servers view in Aptana Studio 3 IDE – I guess their developers are as lazy as I am. I'm not going to continue my research though. Nough! If anyone knows how to stop the server started from Aptana IDE – please do let me know.
Read the original blog entry...
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*Genuine OEM Part # 2615294309. *What's Included : (1) 2615294309 Coupliings. *Replace that old, damaged coupling to keep your tool running at peak performance. *Save 35% buying in the 5-pack. *New, bulk packaged. *Please refer to list below for compatibility : . **Compatible with the following models: 395 (F013039511) Corded Multi-Tool,395 (F0130395CA) Corded Multi-Tool,395 (F013039504) Corded Multi-Tool,395 (F013039510) Corded Multi-Tool,395 (F013039512) Corded Multi-Tool,395 (Type 3) Corded Multi-Tool
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Rating: 5/5Dremel Coupling part
This review is from: Dremel 395 Multi-Tool Replacement Coupling # 2615294309
Pros: Dremel replacement part - proper size and material
Cons: Doesn't install itself
Other Thoughts: I bought this to fix a 25+ year old Craftsman Variable Speed Rotary Tool (Dremel clone) that had stopped working. I'm very happy my tool has a new life.
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To be fair...the previous reviews before booking a room had me very skeptical of the Walls establishment,however to our surprise we were not disappointed. The family and I stayed for 5 days and never had one issue with the Walls establishment. The staff was really nice and accommodating Always had hot water, new towels and bed sheets. plus the pricing was realistic for the duration of our stay. if there were any present errors..it would be only two things that come to mind and that is..The WiFi signal was very weak but that can be due to my wireless provider and the Jacuzzi jets inside the tube were defective. Nonetheless, would I book with them again,YES!
- Official Description (provided by the hotel):
- Just minutes to downtown Long Beach, the Walls Motel is close to many local attractions including the world famous Queen Mary, California State University Long Beach, Aquarium of the Pacific, Seal Beach Wildlife Refuge, golfing, shopping, and more. This Magnuson Hotels affiliate offers free Wi-Fi high speed wireless internet. ... more less
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text: Personhood, Ethics, and Animal Cognition: Situating Animals in Hare's Two Level Utilitarianism By Gary E. Varner No cover image Personhood, Ethics, and Animal Cognition: Situating Animals in Hare's Two Level Utilitarianism By Gary E. Varner Read preview Synopsis R.M. Hare was one of the most important ethical theorists of the 20th century, and one of his graduate students, Peter Singer, became famous for his writings on animals and personhood. Singer now says that he endorses Hare's "two-level utilitarianism," and he has invoked the theory's distinction between "critical thinking" and thinking in terms of "intuitive level rules" in response to certain objections to his conclusions on several issues. Hare, however, never published a systematic treatment of how his theory applies to issues in animal ethics, and he avoided the concept of "personhood." Gary Varner here fills this gap by defending the moral legitimacy of distinguishing among "persons," "near-persons," and "the merely sentient" within Harean two-level utilitarianism. He explores the implications of this distinction by applying the resulting ethical system to our treatment of animals, and shows how the results contrast with the more abolitionist conclusions reached by Singer on the same issues. In the process, he presents a new philosophical defense of two-level utilitarianism and its metaethical foundation (universal prescriptivism), and he significantly expands Hare's account of how "intuitive level rules" function in moral thinking, based on recent empirical research. The book also draws heavily on empirical research on consciousness and cognition in non-human animals as a way of approaching the question of which animals, if any, are "persons," or at least "near-persons. Philosophers, including those interested in utilitarianism in general or Hare in particular, as well as others interested in animal ethics or the debate over personhood, will find Varner's argument of great interest. "Professor Varner's earlier work, In Nature's Interests, is a very fine book. It has achieved a high level of respect from those working in the field, and is often seen as having set a new standard of debate in environmental ethics. That means that a new book by Professor Varner will be received with considerable interest. Varner draws on extensive recent empirical research regarding the degree to which animals are self-conscious and uses this information as the basis for the most serious discussion I have yet seen of whether any nonhuman animals can be considered 'persons'. There is, to my knowledge, no other book that goes into these issues anywhere near as deeply, in the context of assessing their significance for the normative issues of the wrongness of taking life, or other issues relating to ethical decision-making regarding our treatment of animals and some humans. I have no doubt that this book will, like In Nature's Interests, be seen as making an important contribution to the topics it covers." - Peter Singer, University Center for Human Values, Princeton University Related books and articles Books Journals Magazines Newspapers Encyclopedia In Nature's Interests?: Interests, Animal Rights, and Environmental Ethics By Gary E. Varner Oxford University Press, 1998 Read preview Overview The Animal Question: Why Nonhuman Animals Deserve Human Rights By Paola Cavalieri; Catherine Woollard Oxford University Press, 2001 Read preview Overview Zoos and Animal Rights: The Ethics of Keeping Animals By Stephen C. Bostock Routledge, 1993 Read preview Overview Chapter XXII: Utilitarianism of Bentham-Mill-Singer and the Philosophy of Euthanasia By Fenigsen, Richard Fenigsen, Ryszard Issues in Law & Medicine, Vol. 28, No. 2, Fall 2012 Read preview Overview An Unbiased Estimate of Present American Competitiveness from Deontological and Teleological Perspectives of Utilitarianism By Khan, Hamid Competition Forum, Vol. 9, No. 2, 2011 PEER-REVIEWED PERIODICAL Peer-reviewed publications on Questia are publications containing articles which were subject to evaluation for accuracy and substance by professional peers of the article's author(s). Read preview Overview Hutcheson, Smith, and Utilitarianism By Carrasco, Maria A. The Review of Metaphysics, Vol. 64, No. 3, March 2011 Read preview Overview Utilitarianism and the Art School in Nineteenth Century Britain By Beech, Dave Art Monthly, No. 366, May 2013 Read preview Overview Gender, Utilitarianism & Poland: 100 Years of Women and Urban Agriculture By Bellows, Anne Camilla WE International, No. 44/45, Spring 1998 Read preview Overview Zoopolis: A Political Theory of Animal Rights By Belshaw, Christopher The Times Higher Education Supplement : THE, No. 2032, January 12, 2012 Read preview Overview Tracing an Animal-Rights Philosophy By Jonsson, Patrik The Christian Science Monitor, October 9, 2001 Read preview Overview Labia Hosts Animal Rights Festival By Cape Times (South Africa), November 2, 2007 Read preview Overview Animal Rights Group Reloads Complaint against Inhofe By Denwalt, Dale THE JOURNAL RECORD, September 3, 2015 Read preview Overview FREE! utilitarianism The Columbia Encyclopedia, 6th ed., 2015 Read FREE! animal-rights movement The Columbia Encyclopedia, 6th ed., 2015 Read FREE! ethics The Columbia Encyclopedia, 6th ed., 2015 Read VIEW ALL RELATED BOOKS AND ARTICLES


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U.S. private equity deal volume falls 8 percent
Private equity M&A slowed down this year while U.S. mergers benefited from several large deals.
Private equity M&A slowed down this year while U.S. mergers benefited from several large deals.
Mayhoola for Investments, an investment vehicle backed by a major private investor group from Qatar, is to acquire Valentino Fashion Group from Red & Black, a company indirectly controlled by Permira Funds in partnership with the Marzotto family. Red & Black acquired control of the fashion label through in 2007, as part of a wider […]
Gryphon Investors is finally getting to exit Intelligrated after a near 11-year hold.
Permira on Wednesday offered to buy Genesys from Alcatel-Lucent in a deal valued at $1.5 billion. Technology Crossover Ventures, and certain co-investors of the Permira funds, are also taking part in the deal. The transaction, subject to review by Committee of Foreign Investment in the U.S., is expected to close by the end of 2011 or the beginning of 2012. Daly City, Calif.-based Genesys supplies enterprise software and services.
Renaissance Learning said yesterday that it did receive a definitive buyout proposal from Plato Learning that is backed by Thoma Bravo and HarbourVest Partners. Plato is bidding $15.50 a share cash, which includes $128 million equity plus $410 million in debt. However, Renaissance's board said it is still recommending a lower offer from Permira Funds. Permira is offering $14.85 a share cash.


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Tikkun Holistic SpaRead MoreWalking from one treatment room to another inside Tikkun Holistic Spa feels like what walking through a rainbow might be like. The deep blue-greens of the jade room give way to the pink bricks of the Himalayan salt room, and arctic-imitating landscape in the ice room shines a pale blue. Besides exuding a calming atmosphere, Tikkun Holistic Spa has one main goal: to help heal the entire world, one stressed-out person at a time. To that end, reiki master and owner Niki Han Schwarz developed her signature Korean body treatments for clients. Among those treatments is the body scrub and hot oil massage, in which scrubbing mitts exfoliate and hydrate the entire body. The spa also offers a variety of other relaxing treatments that include massage, body wraps, and facials.1460 4th StreetSanta Monica, CA US
Salt ChaletRead MoreIn Salt Chalet's private treatment rooms, sea salt—known for its ability to balance out the body's positively charged ions—fills the air and coats the walls, floor, and ceiling, glittering under soft, ambient lights. As clients relax in lounge chairs or atop massage tables, briny granules flutter through their lungs and waft across their skin—a holistic process known as halotherapy, which recreates the unique microclimate of the world's salt caves away from their bat-shaped novelty shakers. As the chalet's medical director, Dr. Thom Lobe, proclaims, salt rooms can help alleviate everything from allergies and chronic respiratory illnesses to skin disorders, infections, and difficulties sleeping.17401 Ventura BlvdEncino, CA US
Spa 10Read MoreSpa 10 is game for any style you want. That's why it offers a full-service salon to help you look your best. This salon offers a customizable facial that provides powerful and clear results, leaving you feeling refreshed. Avoid wrinkles and gain smooth skin with one of Spa 10's skin treatments, such as a body wrap and a steam bath. Craving a nice relaxing massage? Head on over to this salon and get your fix. Break a sweat with minimal effort at the sauna! Take advantage of the various hair removal methods at this establishment and celebrate being bare. Spa 10's master stylists are trained in beauty services like make up application, and they're ready to help you look your best. Don't wait until the last minute to attend to your needs. This salon's services are only available by appointment. The amenities here may be worth a million bucks, but the prices are rather reasonable. Swipe however you please. Spa 10 accepts all major credit cards. For drivers, a nearby lot is available for use. Nourish your body and mind with a full spa experience at the serene Spa 10.17547 Ventura BlvdEncino, CA US
Massage MastersRead MoreOf course, the marquee draws at Massage Masters are massage services from therapists tapped to service the 1984 and 2004 Olympic teams. Their full-body massages go beyond standard deep-tissue and Swedish modalities to include Serenity massages, Paradise massages, and other bodywork treatments designed to relax and uplift. Staff aestheticians conduct European facials and body polishes that leave physical forms looking as refreshed on the outside as they feel inside. And then there's the salt cave, which helps the body regain balance and fight against disease and toxins. During visits, clients can enjoy free water and ease the transition back into the trappings of their everyday lives—work, traffic, their out-of-date home salt caves—with locker rooms and spa showers.14025 Ventura Blvd.Sherman Oaks, CA US
OC Salt TherapyRead MoreBefore opening OC Salt Therapy, Robert Condraschi spent sleepless nights listening to and worrying about the labored breathing of his 2-year-old son Constantin. After visiting dozens of doctors, all of whom offered different diagnoses for Constantin's ailments, it became clear that surgery was the last viable treatment plan. Before agreeing to invasive measures, Robert and his son booked a trip to the Eastern European salt mines. Within days of basking in the therapeutic chamber, Constantin's breathing grew steadier, and he slept through the night for the first time in years. Now, OC Salt Therapy's founders strive to spark similar recoveries in clients of all ages. They have coated three rooms from floor to ceiling in pure, untreated salt, and each room houses a halogenerator that disperses microscopic particles of salt through the air. In the adult room, clients recline on chaise lounges and listen to soothing music. In the children's room, tykes can tinker with toys, help sentient salt shakers write letters to forlorn pepper grinders, or watch DVDs on flat-screen TVs as parents supervise through the glass door for kids 10 and up, or inside the room for those under 10.12062 Valley ViewGarden Grove, CA US


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The Boss 302 returns to the road after 42 years.
Shaking Hands With The Devil
Watch as a Cobra Jet lines up with a Super Cobra Jet!
Make Your "Five-Oh" Go Faster and Smoother
If you love Ford performance, this is the place for you!
We put together some of our favorite articles about the Ford Mustang!
King of the Road
A Race Car For The Streets
Born on California's highways, the Mustang SSP offered police a high-performance alternative.
How to get up-close and personal to find the finest Ford Mustang you can afford.
A visual guide to telling one vintage Pony Car from its model-year stable mates.
Mustang's third body style emerges.
A visual feast for Mustang lovers.
A Real Jekyll & Hyde Ride
Upgrading a 1966 Mustang's Baer system from two-piston PBR caliper to six-piston Baer caliper.
A fitting end to the S-197 Mustang era.
Daytona Speedway was a fitting corral for these ponies.
Tulsa Raceway Park thundered with Ford power!
Carving corners with Ford power!
Walking around the paddock at Hallett Motor Racing Circuit
The Ultimate Ford Family Reunion
Fords invade downtown Tulsa's Brady Arts District
Walking around Tulsa Raceway Park
The capstone of a great event.
Families, fun and Mustangs at Myrtle Beach.
These cars were built to bring a spark of excitement to the rest of the road going world.
New and old ponies have become a SEMA institution.
It isn't very often that an attraction exceeds expectations by leaps and bounds, but the NASCAR Hall of Fame does so at every turn.
New Power For Old Iron
Hard to define, yet easy to understand, some cars are just perfect.
The biggest show in the automotive aftermarket doesn't disappoint!
Checking out the local flavor in north metro Atlanta.
This may be the "Back To The 50s" show but these 60s cars are welcomed with open arms.
These designers dared to be different.
Back for a second year this early Saturday morning event brought an amazingly diverse group of vehicles.
Here is a brief chance to see these machines sitting still.
Just because an engine lives under the hood doesn't mean it can't be beautiful.
Who needs roads when there are rigs like this!
These second generation Corvettes were first class!
Once again RM delivers with $26.8 million in sales and an impressive list of vehicles.
Las Vegas was flush with fantastic 'Vettes of all ages.
Do horses of a feather flock together?
Four Generations Strong
Classic cars invade downtown Atlanta.
It takes a special kind of truck to haul this much attitude.
A special display of Zagato bodied cars honored the renowned Italian coachbuilder.
While function trumps form in the racing world, there is no denying the beauty of a well engineered racing machine.
The Bruce Weiner Microcar Museum auction by RM Auctions featured some interesting finds, like this mini-Jeep clone!
Wacky, weird, and sometimes just plain odd!
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CHARLOTTE, N.C. — While Republicans rarely brought up former President George W. Bush at their convention last week, Democrats gleefully have paraded him through theirs, saying he left President Obama a mess he's still working to clean up.
Several speakers derided Republican assertions that Mr. Obama has had enough time to turn the economy around, saying the financial hole the Bush administration dug will take years to climb out of.
"No president, not me, not any of my predecessors, no one could have fully repaired all the damage that he found in just four years," said former President Bill Clinton during his keynote speech Wednesday night at the Democratic National Convention.
Mr. Clinton mocked Republicans by saying the theme of their convention in Tampa, Fla., was based largely on a false argument that "we left him a total mess, he hasn't cleaned it up fast enough, so fire him and put us back in."
Sen. Charles E. Schumer of New York, the No. 3 Democrat in the Senate, ridiculed Republicans for ignoring Mr. Bush in Tampa, saying in a speech to the convention Wednesday that it was "no accident that Democrats celebrate our past presidents while Republicans virtually banished theirs."
Mr. Bush didn't attend the Tampa convention, with his main presence relegated to a five-minute tribute video. But even that honor was shared with his father, former President George H.W. Bush.
Norman Ornstein, a political analyst with the American Enterprise Institute, a conservative-leaning Washington think tank, said Republicans are in a no-win situation on whether to defend, condemn or ignore Mr. Bush's legacy.
"Tax cuts combined with two wars unpaid for and a prescription-drug benefit unpaid for … are far the more contributors to our current debt problem than anything that has happened since," Mr. Ornstein said.
Many fiscally conservative, tea party Republicans are highly critical of the administration of the younger Mr. Bush for its penchant for spending and expanding government programs that led to a bloating of the federal debt.
"There are reasons why Bush's name didn't come up very much at the Republican convention other than a sort of feel-good, personal way, because for a policy standpoint, important elements of the contemporary Republican Party don't want to take ownership of what Bush did," said William A. Galston, a political analyst with the Brookings Institution, a liberal-leaning Washington think tank.
"Understandably, the Democrats are using the Bush administration as a drum to beat, and I think they're pretty confident they're not going to get a big push back from Republicans."
Republicans have complained Democrats are taking their blame game against Mr. Bush too far and that Mr. Obama has failed to take enough responsibility for the still-sluggish economy.
Mr. Bush's younger brother, Jeb, a former Republican governor of Florida, has chastised Mr. Obama for attacking his brother, calling on the president to "stop blaming your predecessor for your failed economic policies."
"You were dealt a tough hand, but your policies have not worked," said Jeb Bush during a speech at the GOP convention. "In the fourth year of your presidency, a real leader would accept responsibility for his actions, and you haven't done it."
Democrats do risk pushing the anti-Bush button too much and turning off voters, Mr. Ornstein said. Some Obama surrogates have praised Mr. Bush for his humanitarian efforts, such his 2003 President's Emergency Plan for AIDS Relief, or PEPFAR, which dedicated billions of dollars to expand AIDS prevention, treatment and support programs in countries hit hard by the epidemic.
Mr. Clinton on Wednesday also said he was "honored" to work with both former Bush presidents in relief efforts for victims of the 2004 South Asian tsunami, 2005's Hurricane Katrina and the 2010 earthquake in Haiti.
But Mr. Obama himself must tread carefully when commenting about his immediate predecessor for fear of being perceived as shirking his presidential responsibilities.
"Three-and-a-half years in, you don't want to run for re-election saying, 'Re-elect me, the problem is his,' " Mr. Ornstein said.


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Mark Murphy, founder of CommonsWare, is the author of The Busy Coder's Guide to Android Development, the first, largest, and most up-to-date book on Android app programming, covering Android Studio and the latest Android SDKs. This book gets updated every 6-8 weeks, with subscribers getting access to those updates. The latest update, Version 6.8, added coverage of Android 6.0.
He also offers office hours chats and training on Android app development, in case you are interested in help beyond what fits the Stack Overflow model. He is offering public advanced Android app development seminars in New York City, including:
- "Getting Ready for M"
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Heck, he even has a blog.
All code in Stack Overflow questions, answers, or comments written by Mark Murphy are hereby licensed under the Apache Software License 2.0, unless otherwise noted where that code appears on Stack Overflow. Some of that code comes from his book's GitHub repo or various other CommonsWare open source projects.
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Developers in Tunbridge Wells
1 - 3 of 3
List Map
Berkeley - Royal Wells Park
, Tunbridge Wells, TN4 9QT
Royal Wells Park offers elegant architecture, a welcoming landscaped environment and a truly wide choice of houses and apartments. Located close ... Full details
Blackberry Properties Ltd
A substantial period barn, recently converted to a very high standards, with far-reaching views. Spacious and well laid ... Full details
Dandara - Knights Wood
Knights Way, Tunbridge Wells, TN2 3UW
Now Launched – Phase 1A The Avenue, prices from £365,000. Marketing Suite open daily 10am-5pm Knights Wood The eagerly awaited new ... Full details