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The decline of unlimited mobile data plans
Unlimited mobile data plans are growing scarcer. Find out why and what comes next.
Windows 10 updates potentially costing users on data-capped internet plans
Some Windows 10 users who connect to the internet on slow, data-capped plans may incur costs as a result of downloading system updates.
Windows and UEFI anti-theft mechanism makes systems less secure
Features added in Windows 8 were misused by Lenovo to install unwanted software on top of a clean OS install, introducing a critical vulnerability.
Windows 10 Enterprise edition: What are the key features for businesses?
Inside Microsoft's latest operating system are a number of significant features that business users need to understand.
10 of the best pieces of IT advice I ever heard
Even if IT is the best path for you, you may encounter some stumbling blocks. These career-tested tips will spare you a few headaches along the way.
Quick Tip: Take advantage of Samsung's Ultra Power Saving Mode
Find out about how ultra power saving mode works on the Samsung Galaxy S5/S6.
Windows 10: The smart person's guide
This comprehensive guide covers must-know Windows 10 details, like features, system requirements, upgrade options, and Microsoft's new Windows-as-a-service strategy.
10 things SMBs need to know about Windows 10
The Windows 10 release means big changes for the OS. Here's what SMBs need to know.
Canary home security system: Convenient surveillance in a small package
If you're looking for the most user-friendly home and small business security device on the planet, Canary may have just what you're looking for.
Seven must-read Windows 10 deployment tips for net admins
System requirements, driver compatibility, and update branches are just some of the factors to consider prior to a Windows 10 deploy.


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Salt Lake Bees bring back manager Keith Johnson for third season
Published January 14, 2013 12:13 pm
This is an archived article that was published on sltrib.com in 2013, and information in the article may be outdated. It is provided only for personal research purposes and may not be reprinted.
Salt Lake Bees manager Keith Johnson and his staff will be back at Spring Mobile Ballpark for a third season, the Los Angeles Angels announced Monday.
The 41-year-old Johnson, a former infielder in the Angels organization, led the Bees last year to their 16th winning season.
The team will also bring back hitting coach Francisco Mattos, pitching coach Erik Bennett, trainer Brian Reinker and strength and conditioning coach Josh Fields.
The Bees begin their season April 4.
Aaron Falk
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Company Overview Relypsa, Inc. is a late clinical-stage pharmaceutical company leading the discovery and development of novel non-absorbed polymeric drugs for important applications in cardiovascular and renal diseases. Relypsa's lead product candidate is patiromer, a8/10/2015 Redwood City, CA Save This Job
New York, NY About CRITEO CRTO Criteo delivers personalized performance marketing at an extensive scale. Measuring return on post-click sales, Criteo makes ROI transparent and easy to measure. Criteo has over 1,000 employees in 21 offices across the Americas, Europe and6/10/2015 New York, NY Save This Job
ID 2015-1286 Job Location US-VA-McLean Posted Date 7/30/2015 More information about this job: Overview: COMPANY OVERVIEW Founded in 2000, Logi Analytics provides businesses the fastest and easiest way to deliver business analytics, dashboards, and reports to a broad range of9/1/2015 McLean, VA Save This Job
Chango now part of The Rubicon Project, is changing the way advertisers buy display media, allowing advertisers to speak directly to consumers based on intent data. We are growing rapidly to exceed the needs of our impressive client base, including major, well known retailers9/14/2015 Boston, MA Save This Job
Chango, part of the Rubicon Proejct is a successful, rapidly growing company, with offices in New York, Chicago, San Francisco, London and Toronto. Chango is a programmatic advertising company that uses intent data to identify specific audiences in real time across video,8/15/2015 Chicago, IL Save This Job
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Location:TX - Austin Job Category:Marketing Employment Duration:Full Time # of Openings:1 More and more companies with complex, outsourced networks of suppliers, logistics providers, and distributors lack much needed visibility, collaboration, and control over the9/28/2015 Austin, TX Save This Job
ID 2015-2474 Job Location US-CA-City of Industry - HQ Posted Date 8/11/2015 Category B2B More information about this job: Purpose Of The Job: Take direct responsibility for developing plans and carrying out daily operations to enhance B2B Marketplace8/17/2015 City of Industry, CA Save This Job
We are seeking a Mobile Specialist to collaborate with our Enterprise and Media sales and Client Service organizations to drive strategic mobile solutions for advertisers across all verticals. As the mobile video sales specialist, you will work closely with the head of mobile9/5/2015 New York, NY Save This Job
More information about this job: Overview: Billtrust is a company that leverages leading cloud technology and a commitment to service to support one of the strongest client lists in business. Respected brands like Kraft Foods, CDW, Toshiba, and Stanley Black & Decker rely on us9/8/2015 Hamilton, NJ Save This Job
At Pandora, we're a unique collection of engineers, musicians, designers, marketers, and world-class sellers with a common goal: to enrich lives by delivering effortless personalized music enjoyment and discovery. Peopleâthe listeners, the artists, our advertisers and our9/24/2015 New York, NY Save This Job
Requisition ID 18284 - Posted 05/26/2015 - Remote-US Job Description Print Preview Overview Corporate development teams are increasingly looking to adopt a more structured approach to the transaction process and require technology solutions to more efficiently manage the deal9/16/2015 New York, NY Save This Job
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Requisition Number:701 Job Title:Project Manager Area of Interest:Consulting Services Position Type:Full Time - Permanent Shift: Location:Remote Employees-Home Based City:Nationwide-Remote State / Province:Nationwide-Remote Requirements:See job description below Job8/16/2015 Jacksonville, FL Save This Job
Tracking Code 1883 Job Description The Director of Sales role will provide leadership to address the growth of our business and to collaboratively utilize the full resources of the Company to build the customer?s business and trust. The position is a senior, strategic level9/5/2015 MA Save This Job
Job ID 2015-1067 Job Locations US-GA-Atlanta Category Product Innovations Options: Apply for this job online Not ready to apply? Connect with us. More information about this job: Overview: Cardlytics is seeking a Product Manager-Data Solutions to join the Global Product team.9/11/2015 Atlanta, GA Save This Job
Merchant Support San Luis Obispo, CA Summary The Merchant Support Manager is responsible for planning, recruitment, project management and coordination of the Merchant Support team. This position has direct oversight of the Merchant Support team individuals whose primary9/28/2015 San Luis Obispo, CA Save This Job
City: Calabasas / State: California Job Description The Line 6 National Accounts Manager is responsible for managing and developing a specific list of National Accounts located in the western half of the United States. This9/6/2015 Calabasas, CA Save This Job
Customer Service San Luis Obispo, CA POSITION SUMMARY: The Sr. Onboarding Manager is responsible for the team and processes for the client onboarding experience which aligns with MINDBODY?s brand promise and ensures that service delivery meets quality requirements reflective of9/28/2015 San Luis Obispo, CA Save This Job
Department:Adstation Location:Fort Myers # of openings:1 Description DEPARTMENT OVERVIEW The Mobile-Email Channel develops relationships with publishers and helps them monetize their traffic by giving them access to Adknowledge advertisers through various ad creative options.9/22/2015 Fort Myers, FL Save This Job


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Most people assume that hitchhiking is a long-gone tradition in the 21st century. But in the San Lorenzo Valley, the continued popularity of thumbing it is one example of how things are done a little differently
First: yes, it's true, this is not your grandfather's senior magazine.
How Santa Cruz is celebrating the 'year of books'
How the confusion over GMOs is undermining the organic movement
Santa Cruz's Gary Conley on chasing the swell around the entire African continent on his Suzuki motorbike
Mavericks competition enters new partnership, shortens season
The whims of Mother nature play a major role in whether or not Mavericks is called each year
How surfing helped a local therapist improve his practice
Local surfboard company greens up the industry with an eco-conscious business model


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In search of justice and the precious Star Metal that can help him achieve it, the mighty warrior Conan returns to battle his archnemesis: the evil sorcerer Wrath-Amon and his vicious Snake Cult. Aided by his loyal friends Zula, Greywolf, Jezmine and Snagg, his trusted horse Thunder and lovable phoenix Needle, Conan will do whatever it takes to avenge the stone imprisonment of his family!
These two discs continue the action and adventure of Conan: The Adventurer s second astonishing season!
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great cartoon just wish they would finish the series some dayPublished 1 month ago by Bull Terrier Love
still enjoyed the CONAN cartoons, lot of he episodes came from right out of the COAN books i had read in years gone byPublished 13 months ago by wayne w jackson


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Select Local Merchants
Robins Nest Rhythm and BluesRead MoreRobins Nest Rhythm and Blues in Linden offers flavorful eats and tasty desserts. Patrons have the pleasure of listening to live music while they dine. Take note that the restaurant can get a bit loud, so vocal cords and eardrums should be in tip-top shape. The restaurant's popularity is at an all-time high during the week. Drive to Robins Nest Rhythm and Blues and find parking in the area.3103 Tremley Point RdLinden, NJ US
Luna LoungeRead MoreFor bar nibbles and pub food par excellence, Luna Lounge is a top pick. Dance the night away — the restaurant offers plenty of space to get down. With meters and potential tickets, you'll thank us for our onsite parking! If you don't want a night that will cost you an arm and a leg but you do want a delicious meal, come to Luna Lounge.1906 E Saint Georges AveLinden, NJ US
The CrossroadsRead MoreThe sizzling of Cajun batter-fried shrimp mingles with the sweet twang of acoustic guitars and smoky jazz vocals. This distinct bouquet of sounds and smells is the essence of The Crossroads, a venue that describes itself as an amalgamation of classic Cajun and American stylings: "[It's] as if NY and N'awlins had a baby and moved to the suburbs." Patrons can sate their appetites with a menu of soul and Cajun fare escorted by a choice of libations, including more than 40 martinis. Nightly musical guests have included local and national acts spanning the genres of jazz, bluegrass, and classic-rock cover bands. Nightly events and specials keep energy high. Every Tuesday, guests pay no cover charges and can climb onstage with their finely tuned instruments or an array of water-filled pint glasses for the open Jazz Jam with the house's trio of musicians.78 North Ave.Garwood, NJ US
Marina CafeRead MoreMarina Cafe in Staten Island is known for its tasty eats. Gluten-free and low-fat are not one in the same, but this place serves them both. With Marina Cafe's wide selection of refreshments available, you can tap into the drink menu early in the evening. Marina Cafe is a terrific spot for families to gather with its kid-friendly ambience and menu. The happy hour at Marina Cafe is sure to impress. The patio tables outside of Marina Cafe are the perfect spot for a summer meal. Skip long waits and head to Marina Cafe with your large group for easy seating. For those who enjoy entertainment while dining, Marina Cafe hosts live DJs. Noise levels at the restaurant can be ear-piercing, so save the't te- -t tes for another night. Be sure to call for a reservation if the restaurant is part of your weekend plans — it can get crowded on Fridays and Saturdays. Folks tend to dress down at Marina Cafe, so keep comfort in mind when heading to the restaurant. Marina Cafe prides itself in its delicious catering. You can also grab your grub to go. There are many generous parking options near Marina Cafe, including street, valet and garage. The menu at Marina Cafe is reasonably priced, with most items costing less than $30. For a quick and easy payment solution at Marina Cafe, pay by major credit card. Breakfast, lunch, and dinner are all served at the restaurant, but the dinner menu is the real standout.154 Mansion AveStaten Island, NY US
Z-one Diner & Lounge IncRead MoreZ-one Diner and Lounge serves up classic American favorites hot off the griddle. Comfort food at its best, low-fat is intentionally left off the menu here. Find time to peruse the wine list here — Z-one Diner and Lounge offers a variety of drink options. Little ones are just as welcome as their parents at Z-one Diner and Lounge. Don't miss the happy hour food and drink specials, where a great bargain is always in sight. Outdoor seating is ready for diners on those warm summer days. Z-one Diner and Lounge draws a crowd with performances from live DJs. The restaurant's "rush" is all weekend long, so diners should be prepared to wait for a table. Great place to bring the whole family with great food and a business casual dress code. You might have thought your order was a tough decision, but you still have one more. Delivery or carryout? If you're hoping to make a smashing impression at your next soiree, you can also have Z-one Diner and Lounge cater for you. Patrons will love the number of street and lot parking options close to Z-one Diner and Lounge. For food that tastes like a million bucks, Z-one Diner and Lounge's got you covered for a fraction of the price. Z-one Diner and Lounge has menus for breakfast, lunch, and dinner — just pick your favorite meal and head over. No need to sweat your schedule — the restaurant is open 24 hours a day.1821 Richmond AvenueStaten Island, NY US
Cleopatra LoungeRead MoreCleopatra Lounge is a cute cafe nestled in Staten Island's Eltingville district. Don't be alone on gameday, come have a great drink and great fun. Al fresco eating options are also available at Cleopatra Lounge, which presents a lovely patio seating area for warmer months. If you're feeling up to it, take a turn on the dance floor. Those with sensitive ears may want to stay away from this bar, though, as it can get quite loud. Those hoping to avoid the weekend rush will do best visiting the bar during the week. Restaurant customers can take advantage of the nearby parking options. Our goals are simple. Keep you fed and happy. With outstanding food and drinks priced under $15, we succeed on both counts.4125 Hylan BoulevardStaten Island, NY US


text:
|Systematic (IUPAC) name
|Clinical data
|Trade names
|Paxil, Pexeva, Seroxat, Brisdelle, Rexetin
|Licence data
|US FDA:link
|Legal status
|Routes of
|Pharmacokinetic data
|Extensively absorbed from the GI tract, but extensive first-pass metabolism in the liver[1][2][3][4]
|Protein binding
|Extensive, hepatic (mostly CYP2D6-mediated)[1][2][3]
|Biological half-life
|21 hours[1][2][3]
|Renal (64%; 2% unchanged and 62% as metabolites), Faecal (36%; <1% unchanged)[1][2][3]
|CAS Registry Number
|ATC code
|Chemical data
|Molecular mass
|329.3 g/mol
|(what is this?) (verify)
Paroxetine (also known by the trade name Paxil among others) is an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) type. Paroxetine is used to treat major depression, obsessive-compulsive disorder, panic disorder, social anxiety, posttraumatic stress disorder, generalized anxiety disorder and vasomotor symptoms (e.g. hot flashes and night sweats) associated with menopause[5][6] in adult outpatients.
Differences between newer antidepressants are usually fairly subtle and mostly confined to side effects. It shares the common side effects and contraindications of other SSRIs, with higher rates of nausea, sleepiness, sexual side effects, and weight gain.[7] Discontinuing paroxetine is associated with a high risk of withdrawal syndrome.[8][9] Paroxetine may be associated with a slightly increased risk of birth defects.[10][11][12]
Marketing of the drug began in 1992 by the pharmaceutical company SmithKline Beecham, now GlaxoSmithKline. Generic formulations have been available since 2003 when the patent expired.[13]
- 1 Medical uses
- 2 Adverse effects
- 3 Overdose
- 4 Interactions
- 5 Pharmacology
- 6 Society and culture
- 7 Research
- 8 References
- 9 External links
Medical uses[edit]
Paroxetine is primarily used to treat major depression, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), panic disorder, generalized anxiety disorder (GAD),[14] social phobia/social anxiety disorder,[15] premenstrual dysphoric disorder (PMDD)[16] and menopausal hot flashes.
Paroxetine was the first antidepressant formally approved in the United States for the treatment of panic attacks.[17]
A variety of meta analyses have been conducted to evaluate the efficacy of paroxetine in depression. They have variously concluded that paroxetine is superior[18][19][20] or equivalent[21] to placebo and that it is equivalent[22][23] or inferior[24] to other antidepressants.
Menopausal hot flashes[edit]
On June 28, 2013 U.S. FDA approved low dose paroxetine for the treatment of moderate-to-severe vasomotor symptoms (e.g. hot flashes and night sweats) associated with menopause.[25] Randomized controlled trials have shown modest relief in such cases. At the low dose used for menopausal hot flashes side effects are similar to placebo and dose tapering is not required for discontinuation.[26]
Adverse effects[edit]
Paroxetine shares many of the common adverse effects of SSRIs, including (with the corresponding rates seen in people treated with placebo in parentheses): nausea 26% (9%), diarrhea 12% (8%), constipation 14% (9%), dry mouth 18% (12%), somnolence 23% (9%), insomnia 13% (6%), headache 18% (17%), hypomania 1% (0.3%), blurred vision 4%(1%), loss of appetite 6% (2%), nervousness 5% (3%), paraesthesia 4% (2%), dizziness 13% (6%), asthenia (weakness; 15% (6%)), tremor 8% (2%), sweating 11% (2%) and sexual dysfunction (≥10% incidence).[4] Most of these adverse effects are transient and go away with continued treatment. Central and peripheral 5-HT3 receptor stimulation is believed to result in the gastrointestinal effects observed with SSRI treatment.[27] Compared to other SSRIs it has a lower incidence of diarrhoea, a higher incidence of anticholinergic effects (e.g. dry mouth, constipation, blurred vision, etc.), sedation/somnolence/drowsiness, sexual side effects and weight gain.[28]
Due to reports of adverse withdrawal reactions upon terminating treatment, the Committee for Medicinal Products for Human Use (CHMP) at the European Medicines Agency recommends to reduce gradually over several weeks or months if the decision to withdraw is made.[29] See also Discontinuation syndrome (withdrawal).
Mania or hypomania may occur in 1% of patients with depression and up to 12% of patients with bipolar disorder.[30] This side effect can occur in individuals with no history of mania but it may be more likely to occur in those with bipolar or with a family history of mania.[31]
Paroxetine may increase the risk of suicidal ideation and suicidal behaviour in children and adolescents. Because suicide is rare, it is difficult to test its relationship with the use of paroxetine. Some studies instead analyze suicidality, which generally refers to suicidal ideation and suicidal behaviour. The FDA conducted a statistical analysis of paroxetine clinical trials in children and adolescents in 2004, finding an increase in "suicidality" and ideation as compared to placebo; the trend for increased "suicidality" was observed in both trials for depression and for anxiety disorders.[32] In 2015 a paper published in the BMJ that reanalysed the original case notes[33] argued that in Study 329,[34] assessing paroxetine and imipramine against placebo in adolescents with depression, the incidence of suicidal behavior had been under-reported and efficacy exaggerated for paroxetine.
The American College of Obstetricians and Gynecologists recommends that for pregnant women and women planning to become pregnant, "treatment with all SSRIs or selective norepinephrine reuptake inhibitors or both during pregnancy be individualized and paroxetine use among pregnant women or women planning to become pregnant be avoided, if possible."[10] According to the prescribing information[35] "epidemiological studies have shown that infants born to women who had first trimester paroxetine exposure had an increased risk of cardiovascular malformations, primarily ventricular and atrial septal defects (VSDs and ASDs). In general, septal defects range from those that are symptomatic and may require surgery to those that are asymptomatic and may resolve spontaneously. If a patient becomes pregnant while taking paroxetine, she should be advised of the potential harm to the fetus. Unless the benefits of paroxetine to the mother justify continuing treatment, consideration should be given to either discontinuing paroxetine therapy or switching to another antidepressant." These conclusions are supported by multiple systematic reviews and meta-analyses that found that, on average, the use of paroxetine during pregnancy is associated with about 1.5–1.7-fold increase in congenital birth defects, in particular, heart defects.[36][37][38][39][40]
Discontinuation syndrome[edit]
Many psychoactive medications can cause withdrawal symptoms upon discontinuation from administration. Evidence has shown that paroxetine has among the highest incidence rates and severity of withdrawal syndrome of any medication of its class.[41] Common withdrawal symptoms for paroxetine include nausea, dizziness, lightheadedness and vertigo; insomnia, nightmares and vivid dreams; feelings of electricity in the body, as well as crying and anxiety.[42][43] Liquid formulation of paroxetine is available and allows a very gradual decrease of the dose, which may prevent discontinuation syndrome. Another recommendation is to temporarily switch to fluoxetine, which has a longer half-life and thus decreases the severity of discontinuation syndrome.[8][44][45]
Acute overdosage is often manifested by emesis, lethargy, ataxia, tachycardia and seizures. Plasma, serum or blood concentrations of paroxetine may be measured to monitor therapeutic administration, confirm a diagnosis of poisoning in hospitalized patients or to aid in the medicolegal investigation of fatalities. Plasma paroxetine concentrations are generally in a range of 40–400 μg/L in persons receiving daily therapeutic doses and 200–2000 μg/L in poisoned patients. Postmortem blood levels have ranged from 1–4 mg/L in acute lethal overdose situations.[46][47] It is usually considered, along with the other SSRIs, sertraline and fluoxetine to be a low-risk drug in cases of overdose.[48]
GlaxoSmithKline cautions that drug interactions may create or increase specific risks, including Serotonin Syndrome or Neuroleptic Malignant Syndrome (NMS)-like Reactions:
- The development of a potentially life-threatening serotonin syndrome or Neuroleptic Malignant Syndrome (NMS)-like reactions have been reported with SNRIs and SSRIs alone, including treatment with PAXIL, but particularly with concomitant use of serotonergic drugs (including triptans) with drugs that impair metabolism of serotonin (including MAOIs), or with antipsychotics or other dopamine antagonists.
The prescribing information states that paroxetine should "not be used in combination with an MAOI (including linezolid, an antibiotic which is a reversible non-selective MAOI), or within 14 days of discontinuing treatment with an MAOI", and should not be used in combination with pimozide, thioridazine, tryptophan, or warfarin.[35]
Paroxetine interacts with the following cytochrome P450 enzymes:[28]
- CYP2D6 for which it is both a substrate and a potent inhibitor.[1][28]
- CYP2B6 (strong) inhibitor.
- CYP3A4 (weak) inhibitor.
- CYP1A2 (weak) inhibitor.
- CYP2C9 (weak) inhibitor.
- CYP2C19 (weak) inhibitor.
Paroxetine is the most potent and one of the most specific selective serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitors (SSRIs).[49] It also binds to the allosteric site of the serotonin transporter, similarly, but less potently than escitalopram.[50] This activity of the drug on brain neurons is thought to be responsible for its antidepressant effects. Paroxetine inhibits the reuptake of norepinephrine more than the other SSRIs, just as sertraline inhibits the reuptake of dopamine more than the other SSRIs.[28]
Its affinities are as follows:[51][27]
- SERT (Ki = 0.08 nM)
- NET (Ki = 56.7 nM)
- DAT (Ki = 573.7 nM)
- The following muscarinic acetylcholine receptors (mAChRs):
- α1 adrenoceptor (Ki>100,000 nM)
- Histamine H1 receptor (Ki=22,000 nM)
Society and culture[edit]
GlaxoSmithKline has paid substantial fines, paid settlements in class action lawsuits, and become the subject of several highly critical books in relation to its marketing of paroxetine, in particular the off-label marketing of paroxetine to children, the suppression of negative research results relating to its use in children, and allegations that it failed to warn consumers of substantial withdrawal effects associated with use of the drug.[citation needed]
Withdrawal symptoms[edit]
In 2002 the U.S. FDA published a warning regarding "severe" discontinuation symptoms among those terminating paroxetine treatment, including paraesthesia, bad dreams, and dizziness. The Agency also warned of case reports describing agitation, sweating, and nausea. In connection with a Glaxo spokesperson's statement that withdrawal reactions occur only in 0.2% of patients and are "mild and short-lived", the International Federation of Pharmaceutical Manufacturers Associations said GSK had breached two of the Federation's codes of practice.[9]
Paroxetine prescribing information posted at GlaxoSmithKline now acknowledges the occurrence of a discontinuation syndrome, including serious discontinuation symptoms.[35]
Off-label marketing to children[edit]
In early 2004, GSK agreed to settle charges of consumer fraud for $2.5 million.[52] The legal discovery process also uncovered evidence of deliberate, systematic suppression of unfavorable Paxil research results. One of GSK's internal documents had said, "It would be commercially unacceptable to include a statement that efficacy [in children] had not been demonstrated, as this would undermine the profile of paroxetine".[53]
In 2012 the U.S. Justice Department announced that GSK had agreed to plead guilty and pay a $3 billion fine, in part for promoting the use of Paxil for children.[54]
In 2007, paroxetine was ranked 94th on the list of bestselling drugs, with over $1 billion in sales. In 2006, paroxetine was the fifth-most prescribed antidepressant in the United States retail market, with more than 19.7 million prescriptions.[55] In 2007, sales had dropped slightly to 18.1 million but paroxetine remained the fifth-most prescribed antidepressant in the U.S.[56][57]
Trade names[edit]
Aropax, Brisdelle, Deroxat, Paxil,[58] Pexeva, Paxtine, Paraxyl,[59] Sereupin and Seroxat.
Several studies have suggested that paroxetine can be used in the treatment of premature ejaculation. In particular, intravaginal ejaculation latency time (IELT) was found to increase with 6–13-fold, which was somewhat longer than the delay achieved by the treatment with other SSRIs (fluvoxamine, fluoxetine, sertraline, and citalopram).[60][61][62] However, paroxetine taken acutely ("on demand") 3–10 hours before coitus resulted only in a "clinically irrelevant and sexually unsatisfactory" 1.5-fold delay of ejaculation and was inferior to clomipramine, which induced a fourfold delay.[62]
There is also evidence that paroxetine may be effective in the treatment of compulsive gambling[63] and hot flashes.[64]
Benefits of paroxetine prescription for diabetic neuropathy[65] or chronic tension headache[66] are uncertain.
Although the evidence is conflicting, paroxetine may be effective for the treatment of dysthymia, a chronic disorder involving depressive symptoms for most days of the year.[67]
- ^ a b c d e f "PRODUCT INFORMATION PAROXETINE SANDOZ 20mg FILM-COATED TABLETS" (PDF). TGA eBusiness Services. Sandoz Pty Ltd. 18 January 2012. Retrieved 22 November 2013.
- ^ a b c d e "PAROXETINE (paroxetine hydrochloride hemihydrate) tablet, film coated [Mylan Institutional Inc.]". DailyMed. Mylan Institutional Inc. January 2012. Retrieved 22 November 2013.
- ^ a b c d e "Paroxetine 20 mg Tablets – Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Sandoz Limited. 21 March 2013. Retrieved 22 November 2013.
- ^ a b "Paxil, Paxil CR (paroxetine) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 22 November 2013.
- ^ Katzman MA (2009). "Current considerations in the treatment of generalized anxiety disorder". CNS Drugs 23 (2): 103–20. doi:10.2165/00023210-200923020-00002. PMID 19173371.
- ^ Food and Drug Administration (June 28, 2013). "FDA NEWS RELEASE: FDA approves the first non-hormonal treatment for hot flashes associated with menopause".
- ^ Papakostas GI (2008). "Tolerability of modern antidepressants". J Clin Psychiatry 69 (Suppl E1): 8–13. PMID 18494538.
- ^ a b Haddad PM (2001). "Antidepressant discontinuation syndromes". Drug Saf 24 (3): 183–97. doi:10.2165/00002018-200124030-00003. PMID 11347722.
- ^ a b Tonks A (February 2002). "Withdrawal from paroxetine can be severe, warns FDA". BMJ 324 (7332): 260. doi:10.1136/bmj.324.7332.260. PMC 1122195. PMID 11823353.
- ^ a b "ACOG Committee Opinion No. 354: Treatment with selective serotonin reuptake inhibitors during pregnancy". Obstet Gynecol 108 (6): 1601–3. 2006. doi:10.1097/00006250-200612000-00058. PMID 17138801.
- ^ Yonkers, KA; Blackwell, KA; Glover, J; Forray, A (2014). "Antidepressant use in pregnant and postpartum women.". Annual review of clinical psychology 10: 369–92. doi:10.1146/annurev-clinpsy-032813-153626. PMID 24313569.
- ^ Grigoriadis, S; VonderPorten, EH; Mamisashvili, L; Roerecke, M; Rehm, J; Dennis, CL; Koren, G; Steiner, M; Mousmanis, P; Cheung, A; Ross, LE (April 2013). "Antidepressant exposure during pregnancy and congenital malformations: is there an association? A systematic review and meta-analysis of the best evidence.". The Journal of clinical psychiatry 74 (4): e293–308. doi:10.4088/JCP.12r07966. PMID 23656855.
- ^ Smith, Aaron (May 11, 2005). "New profit twist for drugmakers". CNN Money.
- ^ Baldwin DS, Anderson IM, Nutt DJ, Bandelow B, Bond A, Davidson JR, den Boer JA, Fineberg NA, Knapp M, Scott J, Wittchen HU (2005). "Evidence-based guidelines for the pharmacological treatment of anxiety disorders: recommendations from the British Association for Psychopharmacology". Journal of Psychopharmacology 19 (6): 567–596. doi:10.1177/0269881105059253. PMID 16272179.
- ^ Baldwin D, Bobes J, Stein DJ, Scharwächter I, Faure M (1999). "Paroxetine in social phobia/social anxiety disorder. Randomised, double-blind, placebo-controlled study. Paroxetine Study Group". The British Journal of Psychiatry 175 (2): 120–6. doi:10.1192/bjp.175.2.120. PMID 10627793.
- ^ Yonkers KA, Gullion C, Williams A, Novak K, Rush AJ (1996). "Paroxetine as a treatment for premenstrual dysphoric disorder". Journal of Clinical Psychopharmacology. 16 (1): 3–8. doi:10.1097/00004714-199602000-00002. PMID 8834412.
- ^ Turner, Francis Joseph (2005). Social Work Diagnosis in Contemporary Practice. Oxford University Press US. ISBN 0-19-516878-X.
- ^ Hansen R, Gaynes B, Thieda P, et al. (October 2008). "Meta-analysis of major depressive disorder relapse and recurrence with second-generation antidepressants". Psychiatr Serv 59 (10): 1121–30. doi:10.1176/appi.ps.59.10.1121. PMC 2840386. PMID 18832497.
- ^ Dunner DL, Lipschitz A, Pitts CD, Davies JT (December 2005). "Efficacy and tolerability of controlled-release paroxetine in the treatment of severe depression: post hoc analysis of pooled data from a subset of subjects in four double-blind clinical trials". Clin Ther 27 (12): 1901–11. doi:10.1016/j.clinthera.2005.12.013. PMID 16507376.
- ^ Carpenter DJ, Fong R, Kraus JE, Davies JT, Moore C, Thase ME (November 2011). "Meta-analysis of efficacy and treatment-emergent suicidality in adults by psychiatric indication and age subgroup following initiation of paroxetine therapy: a complete set of randomized placebo-controlled trials". J Clin Psychiatry 72 (11): 1503–14. doi:10.4088/JCP.08m04927blu. PMID 21367354.
- ^ Barbui C, Furukawa TA, Cipriani A (Jan 29, 2008). "Effectiveness of paroxetine in the treatment of acute major depression in adults: a systematic re-examination of published and unpublished data from randomized trials". CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 178 (3): 296–305. doi:10.1503/cmaj.070693. PMC 2211353. PMID 18227449.
- ^ Tignol J, Stoker MJ, Dunbar GC (November 1992). "Paroxetine in the treatment of melancholia and severe depression". Int Clin Psychopharmacol 7 (2): 91–4. doi:10.1097/00004850-199207020-00005. PMID 1487627.
- ^ Gartlehner G, Gaynes BN, Hansen RA, et al. (November 2008). "Comparative benefits and harms of second-generation antidepressants: background paper for the American College of Physicians". Ann. Intern. Med. 149 (10): 734–50. doi:10.7326/0003-4819-149-10-200811180-00008. PMID 19017592.
- ^ Cipriani A, Furukawa TA, Salanti G, et al. (February 2009). "Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis". Lancet 373 (9665): 746–58. doi:10.1016/S0140-6736(09)60046-5. PMID 19185342.
- ^ FDA NEWS RELEASE: FDA approves the first non-hormonal treatment for hot flashes associated with menopause, Jun. 28, 2013http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm359030.htm
- ^ Orleans, Ronald J.; Li, Li; Kim, Myong-Jin; Guo, Jia; Sobhan, Mahboob; Soule, Lisa; Joffe, Hylton V. (2014). "FDA Approval of Paroxetine for Menopausal Hot Flushes". New England Journal of Medicine 370 (19): 1777–1779. doi:10.1056/NEJMp1402080. ISSN 0028-4793. PMID 24806158.
- ^ a b Brunton, L; Chabner, B; Knollman, B (2010). Goodman and Gilman's The Pharmacological Basis of Therapeutics (12th ed.). New York: McGraw-Hill Professional. ISBN 978-0-07-162442-8.
- ^ a b c d Ciraulo, DA; Shader, RI, ed. (2011). Pharmacotherapy of Depression. SpringerLink (2nd ed.) (New York, NY: Humana Press). doi:10.1007/978-1-60327-435-7. ISBN 978-1-60327-434-0.
- ^ "Press release, CHMP meeting on Paroxetine and other SSRIs" (PDF). European Medicines Agency. 2004-12-09. Retrieved 2007-08-24.
- ^ "www.accessdata.fda.gov" (PDF).
- ^ Morishita S, Arita S (October 2003). "Induction of mania in depression by paroxetine". Hum Psychopharmacol 18 (7): 565–8. doi:10.1002/hup.531. PMID 14533140.
- ^ Hammad TA (2004-08-16). "Review and evaluation of clinical data: relationship between psychotropic drugs and pediatric suicidality" (PDF). Joint Meeting of the Psychopharmacologic Drugs Advisory Committee and Pediatric Advisory Committee. September 13–14, 2004. Briefing Information. FDA. p. 30. Retrieved 2009-01-27.
- ^ Doshi P (2015). "No correction, no retraction, no apology, no comment: paroxetine trial reanalysis raises questions about institutional responsibility". BMJ 351: h4629. doi:10.1136/bmj.h4629. PMID 26377109.
- ^ Keller MB; et al. (2001). "Efficacy of Paroxetine in the Treatment of Adolescent Major Depression: A Randomized, Controlled Trial". J Am Acad Child Adolesc Psychiatry 40 (7): 762–772. doi:10.1097/00004583-200107000-00010. PMID 11437014.
- ^ a b c "PAXIL (paroxetine hydrochloride) Tablets and Oral Suspension: PRESCRIBING INFORMATION". Research Triangle Park, NC: GlaxoSmithKline. August 2007. Archived from the original (PDF) on 2011-08-25. Retrieved 2007-08-14.
- ^ Thormahlen GM (October 2006). "Paroxetine use during pregnancy: is it safe?". Ann Pharmacother 40 (10): 1834–7. doi:10.1345/aph.1H116. PMID 16926304.
- ^ Way CM (2007). "Safety of newer antidepressants in pregnancy". Pharmacotherapy 27 (4): 546–52. doi:10.1592/phco.27.4.546. PMID 17381382.
- ^ Bellantuono C, Migliarese G, Gentile S (2007). "Serotonin reuptake inhibitors in pregnancy and the risk of major malformations: a systematic review". Hum Psychopharmacol 22 (3): 121–8. doi:10.1002/hup.836. PMID 17397101.
- ^ Källén B (July 2007). "The safety of antidepressant drugs during pregnancy". Expert Opin Drug Saf 6 (4): 357–70. doi:10.1517/147403184.108.40.2067. PMID 17688379.
- ^ Bar-Oz B, Einarson T, Einarson A, Boskovic R, O'Brien L, Malm H, Bérard A, Koren G (May 2007). "Paroxetine and congenital malformations: meta-Analysis and consideration of potential confounding factors". Clin Ther 29 (5): 918–26. doi:10.1016/j.clinthera.2007.05.003. PMID 17697910.
- ^ "Anti-depressant addiction warning". BBC News. 2001-06-11. Retrieved 2010-05-21.
- ^ Skaehill, Penny A.; Welch, E.B. (October 1997). "Clinical Reviews: SSRI Withdrawal Syndrome". American Society of Consultant Pharmacists. Archived from the original on 2006-05-03. Retrieved 2007-08-15.
- ^ Bhanji NH, Chouinard G, Kolivakis T, Margolese HC (2006). "Persistent tardive rebound panic disorder, rebound anxiety and insomnia following paroxetine withdrawal: a review of rebound-withdrawal phenomena" (PDF). Can J Clin Pharmacol 13 (1): e69–74. PMID 16456219.
- ^ Haddad PM, Anderson IM (November 2007). "Recognising and managing antidepressant discontinuation symptoms". Advances in Psychiatric Treatment 13 (6): 447–457. doi:10.1192/apt.bp.105.001966.
- ^ on Antidepressants & Halting SSRIs by Dr David Healy MD, FRCPsych[dead link]. benzo.org.uk. Retrieved on 2013-04-23.
- ^ Goeringer KE, Raymon L, Christian GD, Logan BK (May 2000). "Postmortem forensic toxicology of selective serotonin reuptake inhibitors: a review of pharmacology and report of 168 cases". J. Forensic Sci. 45 (3): 633–48. PMID 10855970.
- ^ R. Baselt,Disposition of Toxic Drugs and Chemicals in Man, 8th edition, Biomedical Publications, Foster City, CA, 2008, pp. 1190–1193.
- ^ White N, Litovitz T, Clancy C (December 2008). "Suicidal antidepressant overdoses: a comparative analysis by antidepressant type". Journal of Medical Toxicology 4 (4): 238–250. doi:10.1007/BF03161207. PMC 3550116. PMID 19031375.
- ^ Mellerup ET, Plenge P (July 1986). "High affinity binding of3H-paroxetine and3H-imipramine to rat neuronal membranes". Psychopharmacology 89 (4): 436–9. doi:10.1007/BF02412117. PMID 2944152.
- ^ Mansari ME, Wiborg O, Mnie-Filali O, Benturquia N, Sánchez C, Haddjeri N (February 2007). "Allosteric modulation of the effect of escitalopram, paroxetine and fluoxetine: in-vitro and in-vivo studies". The International Journal of Neuropsychopharmacology 10 (1): 31–40. doi:10.1017/S1461145705006462. PMID 16448580.
- ^ Roth, BL; Driscol, J (12 January 2011). "PDSP Ki Database". Psychoactive Drug Screening Program (PDSP). University of North Carolina at Chapel Hill and the United States National Institute of Mental Health. Retrieved 22 November 2013.
- ^ Angell M (15 January 2009). "Drug Companies & Doctors: A Story of Corruption". New York Review of Books 56 (1).
- ^ Kondro W, Sibbald B (March 2004). "Drug company experts advised staff to withhold data about SSRI use in children". CMAJ 170 (5): 783. doi:10.1503/cmaj.1040213. PMC 343848. PMID 14993169.
- ^ Thomas, Katie; Schmidt, Michael S. (July 2, 2012). "Glaxo Agrees to Pay $3 Billion in Fraud Settlement". The New York Times.
- ^ The paroxetine prescriptions were calculated as a total of prescriptions for Paxil CR and generic paroxetine using data from the charts for generic and brand-name drugs."Top 200 generic drugs by units in 2006. Top 200 brand-name drugs by units". Drug Topics, Mar 5, 2007. Retrieved 2007-04-08.
- ^ The paroxetine prescriptions were calculated as a total of prescriptions for Paxil CR and generic paroxetine using data from the charts for generic and brand-name drugs."Top 200 generic drugs by units in 2007". Drug Topics. February 18, 2008. Archived from the original on 2009-07-18. Retrieved 2008-10-23.
- ^ "Top 200 brand drugs by units in 2007". Drug Topics, Feb 18, 2008. Archived from the original on 2009-06-29. Retrieved 2008-10-23.
- ^ Coleman, Andrew (2006). Dictionary of Psychology (Second Edition). Oxford University Press. p. 552.
- ^ Coleman, Andrew (2006). Dictionary of Psychology (Second Edition). Oxford University Press. p. 161.
- ^ Waldinger MD, Hengeveld MW, Zwinderman AH, Olivier B (August 1998). "Effect of SSRI antidepressants on ejaculation: a double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline". Journal of Clinical Psychopharmacology 18 (4): 274–81. doi:10.1097/00004714-199808000-00004. PMID 9690692.
- ^ Waldinger MD, Zwinderman AH, Olivier B (2001). "SSRIs and ejaculation: a double-blind, randomized, fixed-dose study with paroxetine and citalopram". Journal of Clinical Psychopharmacology 21 (6): 556–60. doi:10.1097/00004714-200112000-00003. PMID 11763001.
- ^ a b Waldinger MD, Zwinderman AH, Olivier B (2004). "On-demand treatment of premature ejaculation with clomipramine and paroxetine: a randomized, double-blind fixed-dose study with stopwatch assessment". Eur. Urol. 46 (4): 510–5; discussion 516. doi:10.1016/j.eururo.2004.05.005. PMID 15363569.
- ^ Kim SW, Grant JE, Adson DE, Shin YC, Zaninelli R (2002). "A double-blind placebo-controlled study of the efficacy and safety of paroxetine in the treatment of pathological gambling". Journal of Clinical Psychiatry 63 (6): 501–7. doi:10.4088/JCP.v63n0606. PMID 12088161.
- ^ Weitzner MA, Moncello J, Jacobsen PB, Minton S (2002). "A pilot trial of paroxetine for the treatment of hot flashes and associated symptoms in women with breast cancer". Journal of Pain and Symptom Management 23 (4): 337–345. doi:10.1016/S0885-3924(02)00379-2. PMID 11997203.
- ^ Sindrup SH, Gram LF, Brøsen K, Eshøj O, Mogensen EF (1999). "The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms". Pain 42 (2): 135–144. doi:10.1016/0304-3959(90)91157-E. PMID 2147235.
- ^ Langemark M, Olesen J (1994). "Sulpiride and paroxetine in the treatment of chronic tension-type headache. An explanatory double-blind trial". Headache 34 (1): 20–4. doi:10.1111/j.1526-4610.1994.hed3401020.x. PMID 8132436.
- ^ Gartlehner G, Gaynes BN, Hansen RA, Thieda P, DeVeaugh-Geiss A, Krebs EE, Moore CG, Morgan L, Lohr KN (November 2008). "Comparative benefits and harms of second-generation antidepressants: background paper for the American College of Physicians". Ann. Intern. Med. 149 (10): 734–50. doi:10.7326/0003-4819-149-10-200811180-00008. PMID 19017592.
External links[edit]
|Wikimedia Commons has media related to Paroxetine.
- List of international brand names for paroxetine
- Detailed Paroxetine Consumer Information: Uses, Precautions, Side Effects from medlibrary.org


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My boobs have been feeling full, heavy, and sore in the mornings when I wake up. Throughout the day they become less and less sore. By the time it is night they feel normal to the point that I worry my symptoms are leaving. Then BAM! Sore in the morning again. Weird?
Brandi (.)(.)Gold
M/C 9/24/10, Hudson 2/3/12, Matilda 7/25/14
Brandi (.)(.)Gold
M/C 9/24/10, Hudson 2/3/12, Matilda 7/25/14
In the morning, afternoon, at night, during my sleep! ;D Its a bit ridiculous actually.
1# 9/09 #2 Baby�EDD 2/12
Mine are only sore when I take my bra off before bed and they are really heavy too but when I get up in the morning they are fine for the whole day. I feel the same was just wish they would stay sore all the time so I don't have to worry that something is wrong with my little one. I don't have any major symptoms aside from peeing all the time and I would just like to have one to put my mind at ease.
silesh- I feel the exact same way ;)
Brandi (.)(.)Gold
M/C 9/24/10, Hudson 2/3/12, Matilda 7/25/14
Not weird- mine are the same! Every morning I'm like DANG! Then it seems to subside throughout the day.
Mine are tender all day but definitely worse when I take bra off for bed and when I get out of bed in the morning. Like I walk softly as to not disturn them, lol.
Mine have been doin that too. Instead of a normal bra I have been wearing sports bars and that seems to help some.
yes! every morning I take a few mins. to sit up in bed. I dread that frist few mins of sitting up. My boobs hurt/feel so sore. :/ Glad Im not the only one
-Jennifer (Jen)
Wife to Jerry
Mom to Jayden (5) Jacklyn (3) Emily (Jan '12)
I sleep with a very light bandeau-type bra (no underwire) and it helps a bit. And I thought I had some good, supportive sports bras, but I have yet to get the courage to go to a Zumba or other bounce-around aerobics class...
Alyssa (33) and hubby married 2007 with 1 furbaby Kona
2 Angels 7/10 (11 weeks)and 2/11 (7 weeks)
Jonah arrived 1/29/12!


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2010 Panoplie included in spring 2013 VINsider shipment
The 2010 Panoplie, rated 94 points by Tanzer's International Wine Cellar, 94-96 points by Robert Parker's Wine Advocate and 94-96+ points by the Rhone Report is available exclusively to Tablas Creek Vineyard's VINsider club members. One bottle was included in the spring 2013 club shipment, with VINsiders offered the opportunity to order 3 additional bottles. In addition, VINsiders who reserved this wine as futures in December, 2011 received their wine in the fall of 2012. Ordering the Esprit de Beaucastel and Panoplie en primeur is available exclusively to VINsider wine club members.
We have more information on the VINsider wine club, and more VINsider news.
in worthy vintages, Tablas Creek Vineyard produces small quantities of Panoplie: a Mourvèdre-based cuvée from meticulously selected grapes, made in the model of Château de Beaucastel's Hommage á Jacques Perrin. In 2010, only 600 cases were produced.
The 2010 vintage saw healthy rainfall after three years of drought. The ample early-season groundwater and a lack of spring frosts produced a good fruit set. A very cool summer delayed ripening by roughly three weeks, with harvest not beginning until mid-September and still less than half complete in mid-October. Warm, sunny weather between mid-October and mid-November allowed the later-ripening varieties to reach full maturity. The long hangtime and cool temperatures combined to produce fruit with intense flavors and dark color at low alcohol levels. Syrah was harvested between September 28th and October 13th, followed by Grenache between October 4th and November 13th, Counoise between October 17th and November 6th, and Mourvèdre between October 4th and November 18th.
The grapes for our Panoplie were grown on our 120-acre certified organic estate vineyard.
Each lot was individually fermented using native yeasts in either upright oak casks or stainless steel fermenters. After pressing, the wines were moved into barrel, blended, and aged in one 1200-gallon French oak foudre before being bottled in July 2012.
The Tablas Creek Vineyard Panoplie 2010 shows a wealth of both fruity and savory aromas, including blueberries, plum pit and olive tapenade. The mouth shows a lovely melted licorice character, rich yet tangy, with a saline note characteristic of many 2010's, and a spice note in balance with fruit and mineral components. The finish is long, clean and complex, with beautiful balance. We expect it to drink well for another year or so, then tighten up for a few years before reopening around 2018 and drinking well for two to three decades.
Tasting notes from a December 2012 vertical tasting can be found on the Tablas Creek blog.
Not Available for Purchase
Join us for Paso Robles' annual harvest celebration the weekend of October 16th-18th
All weekend: Visit our tasting room for a first look at our newest Esprit de Tablas wines from the 2013 vintage.
Friday night: Enjoy a four-course, four-wine dinner at McPhee's Grill in Templeton. $105/per person; reservations are essential. Details »
Saturday: Our winemakers will be leading interactive harvest cellar tours 10:30, 12:00, 2:00, 3:30 (20 guest limit). Free to all; no reservations needed. Details »
We are pleased to have been included in recent articles in The New York Times (on creative responses to California's drought) and the Washington Post (on our 11 new AVA's) and to see the attention for Paso Robles. More recent press »
We are thrilled to announce that we've received our shipping permit from the great state of Massachusetts. Residents of the Bay State can now order wine or become VINsider Wine Club members. More shipping news »
October 2, 2015
By: Lauren Phelps
I arrived at the vineyard today at 4:00 AM in the crisp morning air to photograph the "night harvest" of one of our last blocks of Mourvedre. Our crew used only head-lamps and the lights from the tractors to harvest which was challenging to photograph and made for some very interesting and rewarding shots. Read More »


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Book your room at Fairfield Inn & Suites Fort Worth University Drive
Get an overview of this hotel3-star family-friendly hotel near Fort Worth Botanic Garden
This family-friendly Fort Worth hotel is located on a river, within 1 mi (2 km) of Fort Worth Botanic Garden and Fort Worth Zoo. Will Rogers Coliseum and Texas Christian University are also within 2 mi (3 km).
Hotel Features
An indoor pool, a 24-hour fitness center, and a spa tub are available at this smoke-free hotel. Free buffet breakfast, free WiFi in public areas, and free self parking are also provided. Additionally, coffee/tea in the lobby, a business center, and dry cleaning are onsite.
Room Amenities
All 79 rooms provide conveniences like refrigerators and microwaves, plus free WiFi and cable TV. Guests will also find coffee makers, free newspapers, and free local calls.Information missing or incorrect? Tell us!
Hotel Amenities
Hotel Amenities
In addition to an indoor pool, Fairfield Inn & Suites Fort Worth University Drive provides a spa tub and a 24-hour fitness center. A computer station is located on site and high-speed wireless Internet access is complimentary. A business center is on site at this 3-star property. Guests can enjoy a complimentary breakfast each morning. This family-friendly hotel also offers coffee/tea in the lobby, complimentary newspapers in the lobby, and a fireplace in the lobby. Onsite self parking is complimentary.
Fairfield Inn & Suites Fort Worth University Drive is a smoke-free property.
- 24-hour fitness facilities
- 24-hour front desk
- Business center
- Coffee/tea in lobby
- Free newspapers in lobby
- Computer station
- Dry cleaning/laundry service
- Elevator/lift
- Express check-out
- Fireplace in lobby
- Free breakfast
- Free self parking
- Free WiFi
- Indoor pool
- Laundry facilities
- Number of buildings/towers - 1
- Number of floors - 4
- Safe-deposit box at front desk
- Smoke-free property
- Spa tub
- Television in lobby
- Total number of rooms - 79
Family Friendly Amenities
- Cribs/infant beds (complimentary)
- Free Wi-Fi
- Indoor pool
- Laundry facilities
- Microwave
- Refrigerator
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Free self parking
Room Amenities
- Air conditioning
- Blackout drapes/curtains
- Cable TV service
- Climate control
- Coffee/tea maker
- Free newspaper
- Free toiletries
- Free cribs/infant beds
- Daily housekeeping
- Desk
- Free local calls
- Free WiFi
- Hair dryer
- Iron/ironing board
- Microwave
- Phone
- Premium TV channels
- Private bathroom
- Refrigerator
- Shower/tub combination
Where to Eat
A complimentary hot/cold buffet breakfast is served each morning between 7 AM and 9 AM.
Nearby Things to Do
An indoor pool and a spa tub are on site. Other recreational amenities include a 24-hour fitness center.
The recreational activities listed below are available either on site or nearby; fees may apply.
- Hiking/biking trails nearby
- Segway rental/tour nearby
To make requests for specific accessibility needs, complete the "Special or Accessibility Requests" section of "Trip Preferences" when you book your hotel.
- Accessibility equipment for the deaf
- Accessible bathroom
- Accessible path of travel
- Braille or raised signage
- Accessible parking
- In-room accessibility
- Roll-in shower
Hotel Policies
Minimum check-in age is 18
Check-in time starts at 3 PM
Check-out time is Noon
Payment types
Children and extra beds
- Children are welcome.
- Free rollaway/extra beds!
- Free cribs (infant beds)!
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.


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VIDEO: Gov. Chris Christie Visits CBS THIS MORNING
|Related Links
|CBS News Continues to Grow in Audiences & Key Demos
October 09, 2015
|Sneak Peek - President Obama to Talk Russia & Syria on CBS's 60 MINUTES, 10/11
October 09, 2015
|CBS THIS MORNING Posts Year-to-Year Double-Digit % Gains Among Viewers
October 08, 2015
|NBC's TODAY is No. 1 for 5 Straight Weeks in Key Demo
October 08, 2015
Gov. Chris Christie (R-NJ) discussed his political future and Newark, N.J. Mayor Cory Booker's (D) plans to run in the 2014 Senate in an interview with co-hosts Charlie Rose and Norah O'Donnell that was broadcast today, Jan. 9, 2013, on CBS THIS MORNING on the CBS Television Network (7:00 AM – 9:00 AM). Watch the interview in full below!
Below are excerpts from the interview:
ROSE: Can a Republican like you win the Republican presidential nomination? Can you have the views you have and win the nomination?
CHRISTIE: I think that if you have views where you're being effective and you're getting things done for the people, then anybody, not just me, but anybody who does that can win. Here's what I think-I think what's going to happen in the future is that governors, 30 Republican governors out of 50 now, they're going to be the ones who are going to be dictating what the agenda of our party is because we're actually getting things done.
ROSE: You've got a re-election coming up.
CHRISTIE: Yes, sir.
ROSE: Did you scare the Mayor of New Jersey, Cory Booker, out of the race?
CHRISTIE: No.
ROSE: He's looking to the Senate, not to the governor. That's 73% popularity coming out of all of the things following Sandy.
CHRISTIE: Listen. I think Cory made the decision he could best serve the people of this state in New Jersey running for the United States Senate. That was his call and his choice. He's a friend, as you know.
ROSE: Do you agree with him?
CHRISTIE: Do I agree with him? We'll see what the other candidates are at the time, Charlie. Cory has been a friend and we work well over time. I'm glad from this perspective. My daughter follows Cory on Twitter. She says, "You tell Mr. Booker that if he runs against you, I'll un-follow him." So, I'm glad that Sarah doesn't have to un-follow Cory on Twitter.
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Earlier this year, the Consumer Financial Protection Bureau launched a public probe into potentially anti-consumer practices of the student loan servicing industry. More than 30,000 people responded, leading the Bureau, along with the Departments of Education and Treasury, to release a framework they hope will curb these questionable practices, promote borrower success, and minimize defaults. [More]
Feds Recommend Overhaul Of Student Loan Servicing
VW Announces 11M Cars Affected Worldwide By Software That Evades Emissions Standards
While the Environmental Protection Agency ordered Volkswagen to recall nearly 500,000 sedans equipped with software that tricked emissions tests, the carmaker announced on Tuesday that more than 11 million vehicles actually include the so-called defeat device. [More]
Volkswagen Ordered To Recall 500K Vehicles Over Emission Violations
Why Don't Huge Privacy Flaws Result In Recalled Smartphones?
When a car has a major flaw, like a potentially lethal airbag, it gets recalled. Same for a coffeemaker, or a surfboard, or a prescription drug. But when that major flaw is in a product's software — like a huge exploit that puts literally a billion consumers' privacy and personal data at risk — there's no universal process out there for remedying the situation. Do we need one? And if so, how can we get one? [More]
For-Profit College Industry Continues To Bemoan Recently Enacted Gainful Employment Regulations
A month after the implementation of long-awaited regulations aimed at reining in for-profit colleges went into effect, opponents of the new rules aren't simply backing away nicely. Instead, they continue push repeal of the new law, saying it unfairly targets the proprietary schools. [More]
The FCC Wants To Know How Mobile Data, Broadband Caps, And High Prices Shape Broadband Access
It's the FCC's job to determine if broadband internet service is reaching enough people, quickly enough and competitively enough. To make that determination, every year they issue a report looking at the current state of broadband and how it's changed. But broadband isn't about wires anymore; it's about wireless data and how quickly that moves (or doesn't), too. And so the commission is considering a big change to their standards for the next go-around — one that would take a hard look at your cell service, too. [More]
Most State Laws Can't Protect Borrowers From Predatory Installment Loans, Open-End Lines Of Credit
As regulators continue to craft rules meant to crackdown on costly and harmful short-term payday lending, companies are offering alternative products like installment loans and open lines of credit to consumers. But, as it turns out, these cash infusions can be just as devastating to those in need, and few states offer sufficient protections for borrowers. [More]
CFPB Reminds Retailers They Can't Accept Military Allotments For Certain Purchases
Allotments allow military servicemembers to automatically direct some of their paycheck to parties of their choosing, ideally for savings, insurance premiums, housing payments, and support of dependents. Until recently, allotments could also be used to make retail purchases, but such transactions weren't covered by many of the legal protections that come with traditional payment methods like electronic checks and debit cards. Recently enacted rules now prohibit the use of allotments for buying personal property, and federal regulators are reminding retailers they have to follow the law. [More]
San Francisco Creates New Office To Regulate Airbnb, Other Short-Term Rentals
The city of San Francisco and Airbnb have a somewhat contentious relationship, most recently involving tens of millions of dollars in back-taxes the short-term rental company agreed to pay the city earlier this year. Now, to ensure things continue to go smoothly for renters and rentees of services like Airbnb, the city has created a new office for the sole purpose of enforcing rules regarding vacation and short-term rentals. [More]
All Major U.S. Airlines Offer Free Cancellations Within 24 Hours, Except One
Even the most prepared traveler occasionally has to change their itinerary for unforeseen circumstances. While dealing with airlines to make a simple change can be both a test of your patience and a drain on your bank account, if you catch the issue soon enough you might save hundreds of dollars in change fees. That's thanks, in part, to Department of Transportation rules that allow a ticket to be held at the same price for 24 hours before purchase or canceled within 24 hours after purchase — most of the time. [More]
CFPB Proposes Delay Of New Mortgage Rules By Two Months
Prospective homebuyers anticipating a more streamlined disclosure process while buying their dream home may have to wait a little longer, as the Consumer Financial Protection Bureau is proposing a delay to new rules. [More]
New York Regulator Finalizes First-Of-Its-Kind Plan To Govern Virtual Currency With "BitLicense"
Nearly a year after the New York Department of Financial Services took steps to regulate businesses that operate in virtual currency, the Department announced the finalization of the "BitLicense" plan, making it the first set of guidelines for the use of cybercurrency. [More]
There Are Two Things That Could Stop The Comcast/TWC Merger, And We Might Get Both
Update: Comcast is reportedly planning to back out from the merger deal as early as tomorrow in the face of the likely opposition from both the FCC and Justice Department. [More]
Outline For Payday Lending Rules A Good Start, But Not Enough To Fully Protect Consumers
Today, the Consumer Financial Protection Bureau released the first details of long-awaited regulations governing payday loans and other small-dollar lines of credit known to thrust consumers into a devastating cycle of debt. While consumer advocates were quick to applaud the Bureau's work, and those in the financial industry to voice displeasure with aspects of the potential rules, both groups agreed that the coming months will involve more time and effort to craft meaningful protections for both sides of the issue. [More]
Report: Auto Title Loans Just As Bad, If Not Worse Than Payday Loans; Should Face Same Rules
Each year millions of consumers turn to high-interest, short-term loans to make ends meet. While you may be more familiar with payday lenders who charge triple-digit interest rates with the goal of trapping borrowers into taking out new loans to pay off the old ones, a new report finds that payday's lesser-known relative, auto title loans, have equally destructive repercussions. [More]
Report: Teens Buy E-Cigarettes Online With Little Difficulty Despite Industry Safeguards
Back in February 2014, Ohio became the first state to prohibit the sale of e-cigarettes to minors. Since then, 40 other states and cities have followed suit. Despite those regulations, a new study found it's increasingly easy for teens to skirt the rules by purchasing the products online. [More]
Fifth Third Bank Backtracks On Its Pledge To End Payday Loans
In early 2014, the four major banks still offering customers payday loan-like services announced they would discontinue their often under-fire programs by the end of the year. Apparently Fifth Third Bank has changed its mind, announcing plans to continue with a revised, supposedly less harmful version of the service for existing customers. But consumer groups say the revamped service doesn't actually address the problems that led banks to discontinue programs in the first place. [More]
Senators Tell The FDA To Hurry Up Already With Finalizing Those Months-Old E-Cigarette Regulations
When the Food and Drug Administration unveiled proposed regulations for electronic cigarettes back in April, it was an announcement five years in the making. Now several months later little has happened, and a group of senators fear that the failure to quickly finalize the rules has led to the perpetration of misleading health warnings created by tobacco companies themselves. [More]


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Picture It. I Dare You.
On March 8, International Women's Day, the hue and cry for gender equity and a better life for girls and women galvanizes around the theme, "Empowering Women—Empowering Humanity: Picture It!" with the United Nations aiming to "mobilize all people to do their part." When it comes to mobilizing for change, no one moves more nimbly and purposefully than the American nonprofits that first pictured today's global breast cancer awareness movement.
I stepped into this charitable world more than 30 years ago with a promise to my dying sister to end breast cancer. I had no idea how even to begin to create such a change. Over the years, by listening to other women's stories and connecting their power and passion with the larger community, we built Susan G. Komen into the world's largest nonprofit source of funding in the fight against breast cancer. As we grew, the nonprofit sector as a whole became an extraordinary force for transformation. Democratization of good ignited a passionate civic evolution. Now is not the time to let that evolution slow.
The future I see for empowering humanity this International Women's Day is reflected in the faces of three young mothers with late-stage breast cancer whom I met not long ago in Tanzania's Ocean Road Cancer Institute. They had overcome great barriers of stigma, transportation and cost—only to arrive at the clinic in advanced stages of the disease—too late. Today, we are expanding education about breast cancer in Tanzania thanks to the clarion voices of a generation of women and their families who lived and fought the disease.
In its first year alone, Pink Ribbon Red Ribbon screened 27,000 women, identified 5,000 pre-cancerous lesions and referred more than half of those for diagnosis and treatment. Yet, in Tanzania and much of Sub-Saharan Africa, more than 90 percent of women who finally seek treatment are diagnosed in late stages and are unlikely to survive the disease. This is not the time to be satisfied with early achievements.
We must picture a world where bold, groundbreaking scientific research moves quickly from bench to bedside to provide better treatment options for women with advanced cancer and metastatic disease. Where we find gaps in research and treatment, we must work harder to fill them. Today's ever-constricting budgets at the National Institutes of Health and other government funders tend to favor established laboratories, leaving so much promising research unfunded. The average age of an NIH researcher has risen from 39 to 51 since 1982. This is why Susan G. Komen devoted half of its 2014 funding to early career researchers, with a goal to increase that funding by 30 percent in 2015, while continuing to fund the work of well-known scientists and labs. Now is not the time to leave our brightest, young scientific minds struggling for support.
This International Women's Day I dare you to join with me in thinking big, in picturing a world where all women have access to the health care education and services they need. Together, we must dare to find and fund innovative, game-changing scientific research that makes life-saving treatments a reality for women in every corner of the world, and we must dare to envision bold, new global nonprofit collaborations—across sectors and among former competitors—to ensure that women everywhere are empowered in the fight against breast cancer.
The faces of those three young mothers in Tanzania and the motherless children of our own here at home are the reason we fight for a world without breast cancer. Picture it. I dare you.
Komen Funding Launches One Investigator's Career as He Works to Prevent Breast Cancer Metastasis to the Brain
Blog post by Jamie Stanford, Ph.D., Komen Scientific Grants Manager
Susan G. Komen has funded over $135 million in research grants for young investigators. These research dollars are vital as funding for scientific research from the U.S. government becomes more limited, cut by more than $1 billion in the past 4 years. Young investigators are some of the hardest hit by funding cuts. In 2014, the National Cancer Institute funded less than one third of the grant applications submitted by young investigators. Taking on novel research ideas and working with fewer resources and years of experience, young investigators typically have lower success rates than senior investigators. Therefore, many are turning to non-government funding agencies like Susan G. Komen to jump-start their careers. To address this issue, Komen has dedicated itself to 'Sustaining Progress in Cancer Research' by funding nearly $16 million for young investigators alone in 2014.
Dr. Bisrat Debeb is just one of hundreds of young investigators whose careers were launched from Komen research funding. As a postdoctoral fellow in the laboratory of Dr. Wendy Woodward, Dr. Debeb's Komen-funded project focused on understanding how small pieces of RNA (ribonucleic acid), called microRNAs, affect breast cancer metastasis to the brain. Under this fellowship, his training and successful results became the foundation for his career.
During his fellowship, Dr. Debeb and his Mentor, Dr. Woodward, developed new models of brain metastasis and discovered that when breast cancer cells express a microRNA called miR-141, they are more likely to spread (metastasize) to the brain. Likewise, reducing levels of miR-141 prevented breast cancer cells from spreading to the brain. Furthermore, they found that high levels of miR-141 in patient's blood were associated with poor brain metastasis-free survival and low overall survival.
These studies indicate that miR-141 levels in a patient's blood could be used to monitor cancer progression in patients diagnosed with metastatic breast cancer, and that reducing levels of miR-141 could help prevent metastatic spread to the brain.
Now, in his role as Assistant Professor in the Department of Radiation Oncology at The University of Texas MD Anderson Cancer Center, Dr. Debeb's research is a continuation of this Komen-funded project. His studies focus on evaluating the therapeutic benefit of reducing miR-141 levels in order to prevent brain metastasis. Dr. Debeb and his colleagues have also begun to more specifically unveil how miR-141 causes breast cancer to spread to the brain.
Dr. Debeb's contributions to research will bring more hope and options for patients, and his success, which began with data generated from a Komen-funded grant, has opened doors professionally. In fact, he was recently granted the highly competitive National Institute of Health Exploratory/Developmental Research Grant Award. He is also the recipient of the first Junior Investigator Grant from the Inflammatory Breast Cancer Network Foundation. With this new funding, Dr. Debeb will continue to expand upon the project he developed as a Komen postdoctoral trainee. The Komen Postdoctoral Fellowship award "…has been a critical component for my career development and has laid a solid foundation for establishing myself as an independent investigator in the field of breast cancer," says Dr. Debeb.
Learn about our grant funding mechanisms for young investigators.
Read about what our most recently awarded Komen's young investigators are researching.
Your Genes, Environment and Breast Cancer Risk: the Two Sister Study
Why do some women develop breast cancer and not others? And why do some women develop breast cancer at a much younger age? We know that factors like weight, alcohol consumption and hormone replacement therapy, among others, may affect breast cancer risk. But some women with one or more risk factors will never get breast cancer, while some women with no apparent risk factors will still develop the disease.
These questions prompted Komen grantee Dr. Clarice Weinberg, and her colleagues Drs. Dale Sandler and Lisa DeRoo, to conduct a study on how a woman's genes and her environment might affect her risk of breast cancer. In 2008, the researchers launched the Two Sister Study, funded by Komen with a 5-year, $1.75 million grant, along with funding from the National Institute of Environmental Health Sciences (NIEHS).
The Two Sister Study builds upon the work of the Sister Study and focuses on women who developed breast cancer at a young age, with the idea that this group of women can help us learn a lot about the genetic and environmental causes of breast cancer. What makes the Two Sister Study unique is that it gathers data from sisters, who share similar genes and possibly environmental backgrounds.
The Two Sister Study enrolled over 1,400 women recently diagnosed with early-onset breast cancer (under the age of 50), 1,700 of their sisters from the Sister Study (who did not have breast cancer), and parents when possible. Participants provided detailed information about family and medical history, diet, occupation, as well as house dust and DNA samples. After collecting hundreds of samples and surveys from study participants, their sisters and families, Dr. Weinberg and her collaborators identified new potential risk factors for young women. Specifically, the research team found that women who were sensitive to certain hormonal changes differed in their risk for early-onset breast cancer.
They found that reduced risk was associated with:
- Fertility treatments to stimulate ovaries when it does not result in pregnancy.
- Night sweats and hot flashes in pre-menopausal women, which are symptoms typically associated with menopause.
- History of pregnancy-associated hypertension (high blood pressure).
- Hormone replacement therapy with estrogen alone.
Dr. Weinberg also found that women who suffered from menstrual migraines were less likely to develop hormone receptor negative breast cancer (estrogen receptor-negative and progestin-receptor negative). Together, these findings suggest that a young woman's overall response to hormones during the different phases in her life may be related to her risk of developing breast cancer early.
The initial results from the Two Sister Study about a woman's response to hormones add to our knowledge of breast cancer risk factors and early-onset breast cancer. Data from the study are still being analyzed in efforts to identify other risk factors for breast cancer. "The rich data (we have) developed through this family-based study offers a unique window on little-studied possible mechanisms," says Dr. Weinberg. Data on genetic mutations that impact early-onset breast cancer will continue to be mined for years to come as scientists continue to identify both genetic and modifiable (e.g. behavioral) factors related to survival and good health in survivors of young onset breast cancer.
Learn more about Komen's research investment in studies that focus on young women.
The genetic data collected through this research project are now publically available through the NIH's CIDR dbGap website for researchers to use at: http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000678.v1.p1.
Jack Taylor: Senior Investigator, NIEHS
Dale Sandler: Chief, Epidemiology Branch and Principal Investigator, NIEHS
Lisa DeRoo: Staff Scientist, NIEHS and University of Bergen, Norway
Clarice Weinberg: Chief, Biostatistics & Computational Biology Branch and Principal Investigator, NIEHS Stephanie London: Deputy Chief, Epidemiology Branch and Principal Investigator, NIEHS
Paula Juras: Project Officer, NIEHS
Traveling More Than 5,500 Miles to Fight Breast Cancer Disparities
Guest blog by Komen grantee Dr. Lisa A. Newman, MD, MPH, FACS, Professor of Surgery and Director of the Breast Care Center for the University of Michigan in Ann Arbor, Michigan. Dr. Newman has dedicated her career to fighting breast cancer disparities. Named one of the 2012 Michiganians of the Year, she was also featured on CNN's 2009 documentary "Black in America 2." She was even called a "Breast Cancer Hero" in the October 2012 issue of Oprah Magazine.
I am honored to celebrate Black History Month by sharing what I have learned over my career as a surgical oncologist studying the many factors that contribute to disparities in breast cancer outcome, especially as they relate to triple negative breast cancer and African ancestry.
When my training as a surgeon first began (more than twenty years ago), it was widely assumed that the higher breast cancer mortality rates observed in the African-American population were completely explained by the more prevalent socioeconomic disadvantages in this community, with its related diagnostic and treatment delays. Unfortunately, these socioeconomic factors persist today, and they undeniably play a major role in causing tragically higher degrees of pain and suffering from breast cancer.
Over the past few decades, however, we have also made tremendous advances in understanding breast tumor subtypes, and we have learned that African Americans face an increased risk for being diagnosed with more aggressive breast cancers, such as triple negative breast cancer (TNBC). Today, the study of breast cancer disparities related to racial/ethnic identity includes investigations of hereditary genetics and tumor genomics, as well as socioeconomic and health care access inequities.
Although my clinical responsibilities are based in Michigan, my research has led me to sub-Saharan Africa, to learn about the breast cancer burden of women that have shared ancestry with African-Americans dating back to the colonial slave trade era. I have had the privilege of working with the oncology team at the Komfo Anoyke Teaching Hospital in Kumasi, Ghana, for nearly ten years.
What we have learned is striking: similarities indeed exist between the breast cancers identified in Ghanaians and those detected in African Americans. TNBC accounts for approximately 15% of the tumors seen in White American and European patients; approximately 30% of those in African Americans, and the majority of those seen in Ghanaian breast cancer patients. Funding from Susan G. Komen has enabled us to document these patterns and has also supported our studies of novel patterns of expression for molecular markers that are associated with mammary stem cell and TNBC progression, such as EZH2 and ALDH1. This work has also led to a platform for creating a library of patient derived xenografts (PDXs) from TNBC patients of internationally diverse backgrounds. These PDXs are an exciting model for studying the biology of TNBC and treatment sensitivity that can more easily be studied by many scientists for years to come.
Our work at Komfo Anoyke has also provided wonderful opportunities for academic and educational exchange experiences, strengthening our efforts to improve breast cancer survivorship on both sides of the ocean. Students and trainees from the University of Michigan routinely participate in our research trips to Ghana, which have been partly funded by Komen, and our Komfo Anoyke colleagues come to Michigan regularly to participate in research projects and to learn about the latest strategies in breast cancer treatments. One of the Komfo Anoyke surgeons is currently nearing completion of her PhD work in Cancer Biology at the University of Michigan, after which she will return to Ghana to establish an independent Kumasi-based laboratory.
We have also invested in a state-of the-art, internet-based telemedicine conference facility at Komfo Anoyke. This program allows us to host ongoing live weekly meetings and educational conferences, uniting our teams in Michigan and at Komfo Anoyke as one, overcoming the thousand-mile geographic separation to review cases and strategize the treatments that will best benefit our patients.
Our international breast cancer research program now works with three different hospitals in Ghana, and we are also in the process of obtaining approvals for participating sites in Ethiopia, India, and China.
Research has brought us many clues about the origins of breast cancer, and why it may affect some groups of women differently. But there is still much to learn about the biology of breast cancer that affects women of African Ancestry. I am pleased that our work, which began in Michigan, continues to be strong in Ghana and is now spreading to other African countries.
Read a recent Komen Perspectives article on triple negative breast cancer (TNBC).
Learn more about Komen's work on breast cancer disparities in our Mission Fast Facts.
Now that I have breast cancer on one side, should I remove both breasts?
Guest blog from Komen Scholar Dr. Ann Partridge, Associate Professor, Department of Medicine, Harvard Medical School; Director, Program for Young Women with Breast Cancer, Susan F. Smith Center for Women's Cancers; Director, Adult Survivorship Program Dana-Farber Cancer Institute
A breast cancer diagnosis can be a really scary thing. Even though doctors and statistics can reassure women that most will be ok in the long run, many women worry that, "they were the one that got breast cancer, and they may be the one that hears from it again." And, understandably, they may want to do every possible and reasonable thing they can to reduce that chance.
One potential option for reducing the risk of breast cancer that has received increasing attention in recent years is "contralateral prophylactic mastectomy" or CPM. CPM is a procedure where both breasts are removed (bilateral mastectomy) even though breast cancer is only in one breast (unilateral breast cancer).
Rates of CPM have increased dramatically in the past decade, drawing the attention of doctors who care for women with breast cancer, as well as researchers trying to understand this trend. Generally speaking, is CPM good for women in the long run? Or is there something we should do to reverse this trend? There are a number of reasons women may choose to remove or not remove a healthy breast, and women should understand the risks and benefits of CPM in order to make the best decisions for their lives.
So, what has research shown us so far? First, and most importantly, studies have shown that, in the long run, removing a woman's healthy breast when she has breast cancer in the other does not improve overall survival. This is because the vast majority of breast cancer survivors will not develop a new breast cancer in the other breast (which is essentially the only scenario a woman is preventing when she removes the healthy breast). Exceptions could include women with a known genetic predisposition to breast cancer like those with a BRCA 1 or BRCA 2 gene mutation, whose risk of a new breast cancer occurring in the other breast is higher.
Further, a woman who has been previously diagnosed with breast cancer is generally being watched closely with more frequent follow-up screenings. So, even if a second breast cancer develops in the healthy breast, it is usually caught early, and she will be treated quickly.
Many women I see in my clinic that are making surgical decisions think they are reducing the chances that their breast cancer will come back by removing the other, unaffected breast. But this is not the case. For most women, if a breast cancer is going to come back, it is usually not to the other breast. As women learn this, they often think differently about the idea of removing their healthy breast.
Another thing to consider is that any potential decrease in risk resulting from CPM does not decrease the possibility of the primary breast cancer spreading or recurring elsewhere in the body (metastasizing).
There are a few key things women should know about mastectomy as well. Although mastectomy is a safe procedure and major complications are rare, there are potential negative consequences, including cosmetic concerns, and other potential long-term effects such as numbness of the chest skin, swelling, chronic pain and decreased motion of the upper arm. Given most women also opt for reconstruction, it's important to consider the extended recovery time, added surgical complications, and decreased strength or function due to muscles being moved or stretched.
On the other hand, women have shared a number of reasons with us that cause them to consider CPM. For some, the idea of having any chance of a new breast cancer in their healthy breast is very anxiety-provoking, as is consideration of follow-up mammograms to screen for new breast cancer in the future. They would prefer to never have to deal with that again and are willing to undergo CPM to prevent it. Cosmetic concerns may also be a driver, with the desire to have two reconstructed breasts that look similar instead of one treated breast and another natural breast. Although, plastic surgeons today can do much to help recreate a more natural look, ensuring both breasts looks similar and symmetrical.
Recent studies have indicated that fear of recurrence and anxiety are strong predictors of whether women will choose CPM. Improved education and counseling about the risks and benefits of CPM, as well as increased awareness and management of anxiety surrounding breast cancer diagnosis and treatment, are likely to help women understand their risks more fully and make decisions consistent with their preferences and values.
Researchers are working on tools called "decision aids" to help women to make the best decisions for themselves, in conjunction with their doctors, which may be particularly helpful for women going through this difficult process in the future.
For any woman dealing with this decision, it is important to learn the facts and discuss their concerns with their doctors in order to make the best decision. I also always recommend that women take their time to be sure. Sometimes this means waiting to take action with the other breast, because once it's removed, you can't put it back on!
Ultimately, this is a very personal decision and women need to be supported with information and emotional support to do what is best for them.
Read a recent Komen Perspectives on prophylactic mastectomy.
Learn more about BRCA1 and BRCA2 gene mutations.
Learn more about breast reconstruction
Learn more about social support and find a list of support resources.


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Carrie Underwood - Page 9
Carrie Underwood's Husband Ignites a Bromance With Blake Shelton
Blake Shelton is brewing a new bromance, and this time, it's not with his buddy from 'The Voice,' Adam Levine. It's actually someone very familiar to country red carpets: Carrie Underwood's husband Mike Fisher!
Carrie Underwood Fan Undeterred by Lightning Strike, Hot Plate Burn, Seizure
Carrie Underwood, meet your most loyal fan! At Country Fest in Cadott, Wisc. over the weekend, Gage Stroening did all he could to see the Underwood -- and meet Randy Houser -- after being jolted by lightning and stepping on a red-hot hot plate. Following a brief seizure and visit to the emergency room, the Minnesota man was back at Country Fest.
Carrie Underwood Returns as Voice of 'Sunday Night Football'
Are you ready for some football? We know one country star who definitely is -- Carrie Underwood is making her return to 'Sunday Night Football.'
Remember When Carrie Underwood Was (Sort of) on 'Sesame Street'? [Watch]
At least it looked like Carrie Underwood. In fact, this "girl" even sounds like Carrie Underwood. Take a look … you'll see there's something about this 'Sesame Street' character that isn't quite right.
'Somethin' Bad': Miranda Lambert and Carrie Underwood Team Up For Killer Music Video
Jennifer Nettles and Carrie Underwood Duet '9 to 5′ on the Opry Stage [Watch]
Jennifer Nettles and Carrie Underwood make playing the Grand Ole Opry look easy. The pair got together on the historic stage recently to play their own rendition of a well-loved Dolly Parton classic.
Carrie Underwood Heads to Haiti for Mission Trip
Carrie Underwood is taking time away from her life as a country superstar and going on a mission trip in Haiti.
Miranda Lambert + Others Thrill Fans With CMA Fest LP Field Shows [PICTURES]
The 2014 CMA Music Festival is officially underway, and night two of the country music party was just as sensational as the first. This time, Miranda Lambert, Blake Shelton, and other top-notch country stars thrilled fans with their sets, and a superstar -- the one and only Carrie Underwood -- made a surprise appearance.
ToC Encore: The Best of Country Music 2014 (So Far)
As 2014 nears the halfway point, it's time to reflect on the best of country music. The best songs, the best albums and the best moments of 2014 come from newcomers and superstars. They come from awards shows and reality television. The Best of Country Music 2014 comes from all over.


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Toronto 2012: Magnolia Pictures Acquires North American Rights to 'The Brass Teapot'
The fantasy comedy stars Juno Temple and Michael Angarano.
TORONTO — Dealmaking continued at a steady pace on Friday as Magnolia Pictures acquired North American distribution rights to The Brass Teapot, which marks the feature directorial debut of commercial and music video director Ramaa Mosley.
The fantasy-comedy, making its premiere earlier this week at the Toronto International Film Festival, headlines Juno Temple and Michael Angarano. The duo play broke newlyweds who stumbled upon a magical teapot that rewards physical pain with wads of cash. However, they soon learn to be careful for what they wish for.
Mosely developed the story, with Tim Macy developing the script. Brass Teapot was produced by Darren Goldberg of Atlantic Pictures, Kirk Roos of Northern Lights and James Graves.
PHOTOS: TIFF Day 7: 'Smashed,' 'A Royal Affair'
"I am looking forward to working with the team at Magnolia Pictures," said Mosley. "For my first feature film, it is incredibly exciting to partner with such a great company who is so passionate for indie film and shares my love for the project."
Magnolia president Eamonn Bowles added: "The Brass Teapot is a remarkably funny and assured debut from the very talented Ramaa Mosley. Michael Angarano and Juno Temple have terrific chemistry in this dark comedy that manages to be sincerely sweet and romantic without ever losing its bite."
Magnolia Pictures' director of acquisitions Peter Van Steemburg negotiated the deal; The Gersh Agency represented the filmmakers.
Brass Teapot marks the second Toronto deal so far for Magnolia after documentary No Place On Earth.
Magnolia Pictures is the theatrical and home entertainment distribution arm of the Wagner/Cuban Companies.
Never miss a story. Stay up-to-date with THR's Daily Headlines.
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Voting against the Mafia in what he thinks is a secret ballot costs Sicilian laborer Mimi (Academy Award (c) Nominee Giancarlo Giannini, Seven Beauties, Man on Fire, Quantum of Solace ) his livelihood in Lina Wertmuller's (Swept Away) dark comedy. He leaves his wife, flees to Turin and romances a Communist organizer (Mariangela Melato, Swept Away, Flash Gordon) -- but he just can't shake the Mafia. When they lure Mimi back to Sicily with a better job, he must keep his lover -- and love child -- under wraps. That's when his wife announces she's pregnant.
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I am profoundly shocked that this movie has had the attention of only 9 reviews......
Perhaps it isn't the "masterpiece" that "Swept Away" and other titles that escape me... Read more
bought this for my boss last year. he had been looking for it for a long time. he was shocked that i had found it and was happy the movie worked so well.Published on November 27, 2012 by Barbara A. Higgins
The theme of this story is the prideful narcissism that leads a self-serving, dissatisfied laborer to create overwhelming obligations he cannot control in the context of social... Read morePublished on May 5, 2007 by J. Brackett