text:
At last have seen proper movies with an interesing and unexpected plot i.e. The Girl with the Dradon Tattoo and its sequel. The films coming from Hollywood at the moment are dire and dumbed down. Well done Stieg Larsson and Sweden.
- Kate Carmichael, 6 November 2010
Eva.....love the books! THEY are selfish men!
- , 6 November 2010
Stieg Larsson is a born genius!!!!!!!!!!!! His Millennium-trilogy is addicting. Truely one of the best writing I've ever read. I currently started reading the 3rd novel "The girl who kicked the Hornets nest"! Larsson has done it again.
I simply can't put the book down. It's like a drug one can't resist!
Or M & M's ya can't just eat just one.. I want more of Larsson. Let his
companion Eva Gabrielsson finish what would be his finaly bow to his legacy.
- Denise-Virginia 5 November 2010, 5 November 2010
- Hans, 4 November 2010
The best books I've read in a long time. They are simply amazing ! I'm reading the second one in the serie and I intend to finish it tonight. I can't wait to start the third. (Too bad some on this board are killing the intrigue by revealing information though !)
- Denise - Canada, 4 November 2010
So, at least we now know what happened to Mikael fucking Blomkvist - heart attack (Sapo knows how to do such things?). Such a tragedy I feel in my heart as the loss of a family member who was better than any of us knew. Thanks Mikael, or Stieg, however you want it. Wish you were here
- Robert & Tucker, 4 November 2010
Love Stieg Larsson!
Hope his wife will let them finish the fourth book though.
But no one can write in the way Stieg did, it´s a unique way!
Can anyone manage to end that book in his kind of way???
The Swedish films are great, will be interesting how the American versions will be. We have films of all three books in Sweden already.
I look forward to that first film of the first book.
If you haven´t read the book yet, I highly recommend ppl to do that.
- Heli-Maria, Sweden., 4 November 2010
It stops here! Larsson strikes a chord. Damn I wish he would"nt have smoke so much. His insight on issues dealing with a persons individual rights knocks my socks off.
- firstname.lastname@example.com, 3 November 2010
Felt the movie left too much out. Book was much much better. If you had not read the book I think it would have been hard to follow the story. The Actress was a bit disappointing as not what or how I pictured Lisbeth in the book. Loved all the books. Could not put them down once started.
- ellen, 3 November 2010
All 3 books are great.......after a very long time I came across crime thrillers that I just could not put down until the last page had been turned. I really hope that Lisbeth Salander continues to live on through more books in this series.......the character is incomparable.......as good if not better than 007!
- Avinash Varma, 2 November 2010


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Jun. 3, 2014, 1:54 AM
- Massachusetts has sued Fannie Mae (FNMA) and Freddie Mac (FMCC), saying they violate state law by blocking foreclosure buyback programs.
- Buyback programs allow a non-profit organization to purchase a foreclosed home and then resell it back to the original owner at a more reasonable price.
- Massachusetts passed a law in 2012 prohibiting creditors from blocking such programs, although Fannie Mae and Freddie Mac have failed to comply.
May 20, 2014, 11:01 AM
- Perhaps sensitive over the press bruising he's taken for being the puppetmaster behind government investigations of Herbalife, maybe look for Bill Ackman to try and stay out of the spotlight on Fannie Mae (FNMA +2.1%) and Freddie Mac (FMCC +2.1%), writes Dan Freed.
- Ignoring for the moment Ackman's 110-page slide presentation on the GSEs at Ira Sohn two weeks ago, a source close to the hedge funder says don't expect a big public campaign a la Herbalife or Allergan. While Bruce Berkowitz has publicly offered his policy assistance over Frannie to the government and Blackstone has done so privately, Ackman's camp believes D.C. has little interest in the advice of hedge funds in this instance.
- For anyone who heard at least snippets of Ackman at Ira Sohn, we'll file this story under "believe it when we see it."
May 16, 2014, 3:55 PM
- "I don't lay awake at night worrying about what's fair to the shareholders," says FHFA boss Mel Watt in an interview to be aired on Sunday. "There would be no Fannie (FNMA -1.8%) or Freddie (FMCC -1.2%) but for the taxpayers."
- Watt also notes the he had no role in altering the bailout agreements to allow for the continuous taking of all GSEs profits by Treasury. "I don't know whether I would have thought differently had I been there, but I don't have that luxury ... It's an arrangement that I'm comfortable operating under."
May 15, 2014, 12:20 PM
- The Senate Banking Committee today passed a bill to wind down Fannie Mae (FNMA -2.8%) and Freddie Mac (FMCC -3%), but the vote, 13-9 in favor, looks too narrow to force the full Senate to vote on the legislation. The bill's authors say they'll try and add support in coming weeks, but the chances of something winding up on the President's desk this year look slim.
- Previously: U-turn on GSE mortgage policy
May 14, 2014, 6:24 AM
- Obtaining a mortgage may be about to get a lot easier as FHFA chief Mel Watt - in his first public speech since taking over as regulator of Fannie Mae (FNMA) and Freddie Mac (FMCC) in January - says the mortgage giants should focus on making credit more readily available to homeowners.
- The call is a U-turn from the policy of previous FHFA boss Ed DeMarco. "I don't think it's FHFA's role to contract the footprint of Fannie and Freddie," says Watt, adding that winding down the companies without proof private investors are willing to fill the gap "would be irresponsible."
May 8, 2014, 7:59 AM
- Fannie Mae (FNMA): Q1 Net income of $5.7B
- Revenue of $9.1B (+31.9% Y/Y) beats by $3.48B.
- Press Relase (pdf)
May 8, 2014, 7:41 AM
- Fannie Mae (FNMA) Q1 net income of $5.3B vs. $5.7B in Q4, and includes $4.1B in revenue from legal settlements.
- Expected $5.7B dividend payment to Treasury will bring total to $126.8B vs. $116.1B in draws.
- "Fannie Mae expects to remain profitable for the foreseeable future," but annual net income going forward should be "substantially lower" than 2013.
- Press release
May 6, 2014, 12:01 PM
- Now making the rounds is Bill Ackman's 111-page slide presentation laying out the bull case on Fannie Mae (FNMA +2.9%) and Freddie Mac (FMCC -0.7%)
- Yesterday: Ackman pitches Fannie and Freddie at Ira Sohn
- Ackman notes much of the GSEs losses during the financial crisis - which pushed their capital levels far below minimum requirements and precipitated the bailout - were due to credit provisions. What actually happened, though, were losses of "just" $102B, or $142B less than the cumulative provisions taken from 2007-2011.
- Further, much of those losses were the result of an ill-fated move to guarantee Alt-A and subprime loans. Losses from just the core portfolio of prime mortgages would have been only barely enough to push the GSEs below their minimum capital levels.
May 5, 2014, 3:47 PM
- Finally addressing Congressional plans to wind Fannie (FNMA +2.8%) and Freddie (FMCC +1.8%) down, Ackman isn't buying it. A private-label replacement would need to raise $500B to capitalize itself, he says - not likely given the government's "stealing" of the GSEs dividends. "We don't think there's an investor in the world of any consequence that will invest in a new version of Fannie and Freddie."
- Previously: Ackman pitches Fannie and Freddie at Ira Sohn
May 5, 2014, 3:35 PM
- One of the hot hands in the hedge fund world at the moment, Bill Ackman reiterates his bull case on the GSEs. Owning Fannie Mae (FNMA -1.8%) and Freddie Mac (FMCC -1.8%), he says, is like owning a royalty on the housing market.
- Ackman first disclosed stakes in the common stock of both last November and boosted those bets with a derivative play earlier this year.
- Earlier Sohn conference coverage
- Live blog
Apr. 30, 2014, 11:09 AM
- Under the FHFA's baseline scenario, neither Fannie Mae (FNMA -1.3%) nor Freddie Mac (FMCC -1.8%) would require addition draws from the Treasury through 2015, but under the "severely adverse" scenario applied to the banks by the Fed in its stress tests, incremental draws of between $84.4B and $190B would be necessary.
- The severely adverse scenario includes a 25% decline in home prices over about a two-year period, a 20-90% decline in non-agency MBS prices, and the instantaneous default of the largest derivative counterparty.
- Under the worst FHFA scenario, home prices would decline 2% over nine quarters.
Apr. 29, 2014, 5:09 AM
- The Senate Banking Committee is due to meet today to discuss replacing Fannie Mae (FNMA) and Freddie Mac (FMCC) with an agency that will offer a government mortgage guarantee but only after private interests have absorbed big losses.
- However, the agency would still preserve the 30-year fixed rate loans that are at the center of the mortgage system.
- The 22-member panel is expected to approve the proposals, although supporters want at least 16 votes so they can pressure for a ballot on the Senate floor.
- Previous
Apr. 28, 2014, 8:09 AM
- As soon as tomorrow, the Senate Banking Committee will decide if GSE reform legislation - which would wind down Fannie Mae (FNMA) and Freddie Mac (FMCC) over five years - will move forward or not. At the moment, committee leaders are involved in busy horse-trading to win over a few of the half-dozen Democrats on the panel who haven't yet come out in support.
- An impasse means the status quo - in which the two companies operate under federal control with no resolution on the status of privately-owned stakes - could continue for years.
- At the moment, a majority looks to be in place to move the bill out of committee, but Majority Leader Reid is expected to allow a floor vote only if more Democrats come on board. "Senate leadership appears far from enthused by the prospects of a floor vote on the measure," says Compass Point's Isaac Boltanksy. "Reforming the mortgage market just doesn't fit into the pre-election priorities of either party."
Apr. 25, 2014, 4:43 AM
- The amount that lenders originated in mortgage loans plunged 58% on year Q1 to a 14-year low of $235B, almost entirely due to drop in refinancing. The figures are from industry newsletter Inside Mortgage Finance.
- Loans for acquisitions were flat on year and lower than in Q4.
- The trend is the latest indication that increasing interest rates are hampering the housing recovery. The average 30-year fixed-rate mortgage was 4.5% last week, up from 3.6% in May last year, when rates spiked after the Fed indicated it would scale back its QE program.
- Tickers: DHI, PHM, RYL, MHO, NVR, LEN, SPF, MDC, HOV, TOL ORI, NLY, AGNC, MTGE, ARR, TWO, IVR, CMO, MFA, WMC, FMCC, FNMA, RDN, NMIH, ESNT, GNW
- ETFs/ETNs: ITB, XHB, MORT, MORL, REM, MORT, MORT
Apr. 24, 2014, 8:17 AM
- "Any time a large financial institution starts promising regular earnings increases, you're going to have trouble," Warren Buffett famously said in 2010, explaining why he dumped stakes in Freddie Mac (FMCC) and Fannie Mae (FNMA) many years before the housing bust.
- As for whether Berkshire Hathaway (BRK.A, BRK.B) has any interest in the GSEs at this point, the answer is "no," says Buffett in a Bloomberg interview. Buffett does though, see a role for government in housing finance. "The 30-year fixed-rate mortgage is very good for the American public and I think that you will need government participation in some way to bring the costs down."
Apr. 22, 2014, 12:19 PM
- The markup session for the housing-finance reform bill - which has the support of the bipartisan leadership of the Senate Banking Committee - is set for April 29, leaving only about one month for Congress to vote before election season begins. Height Analytics' Edwin Groshans thinks there's less a less-than 5% chance of passage this year.
- By scheduling such a late markup session, lawmakers hoped to have time to raise support for the complex bill which would include the contentious wind-downs of FNMA and FMCC. There is, of course, a wide chasm between the Senate and more conservative House views, but there's also Fannie and Freddie shareholders looking to be heard.
FNMA vs. ETF Alternatives
Company Description
Fannie Mae is a government-sponsored enterprise that was chartered by Congress in 1938 to support liquidity, stability and affordability in the secondary mortgage market, where existing mortgage-related assets are purchased and sold.
Sector: Financial
Industry: Savings & Loans
Country: United States
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Property is in demand due to reduced inventory, as there are more potential buyers than sellers. Bidding wars with other buyers are possible, and listings begin to sell at greater than the asking price.
Rental property is in high demand and availability is low. Rent prices have decreased by 33% over the past 3 months. This is 236% lower than the county average of $5,548 and 145% lower than the state average of $4,043.
The average home price in Center Moriches is $393,000, which is 21.9% higher than the average sold price in Center Moriches ($322,500) . The average home price per square foot in Center Moriches is $164 and about 2% of all homes in Center Moriches sold in the last 6 months. For Center Moriches home values, real estate prices, and city market trends, research the 2,797 property records or search our 69 recently sold or 149 homes for sale listings. The listings and properties in Center Moriches are only a part of the 4,728,288 properties and 137,363 homes for sale in New York. Because of this, the average home price and average home value of Center Moriches also influence the average home price $249,900 and average sale price $278,500 of New York. Listing counts, Center Moriches home prices and home values in Center Moriches are sourced daily from listing and property data on realtor.com®, which is the most up-to-date and accurate aggregation of real estate listings in the industry and includes approximately 800 regional MLSs and is the official website of the National Association of Realtors®.


text:
Today's share day is for the Star Trek fans. (You don't have to be a fan to share) Here we go, I just read that there will be Klingons in the new Star Trek Movie. So today let's talk Klingon.(Not in Klingon, because most of you know I have a hard enough time with English) What do you really think happen to the Klingons of the original show? I think that they were genetically altered Klingons, made to look more human in order to infiltrate the Federation. As you know, it didn't work. They were then sent to another planet to live out their lives as outcast, because they failed. This planet was later destroyed to forever hide the truth. Sounds good to me, does anyone else have any idea what happen to them?
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48 reviews
56% would repurchase
Package Quality: 4.1
Price: $$$
Package Quality: 4.1
Price: $$$
INGREDIENTSTablet weight: 512 mg Each tablet contains Shark cartilage (Mako, Tiger, Dogfish) 250 mg Oyster (oyster meat) 50 mg Acerola cherry (Malpighia punicfolia, Berries) (std. 25% Vitamin C) 120 mg Silica (Equestrian arvense) Aerial parts 2.7 mg Non-medicinal Ingredients: Glycerin, hydropropyl methycellulose, Magnesium stearate, maltodextrin, Microcrystalline cellulose, orange flavouring, Silicon dioxide.
on 9/23/2015 7:02:00 PM
Age: 30-35
Skin: Combination, Fair, Not Sure
Hair: Brunette, Other, Other
Eyes: Blue
I used Vivascal for 3 months. While I used it my nails started growing super quickly and they were very strong. Also all along my hairline I got a bunch of new hair growth. Right now it's all sticking straight up and out because it's not long enough to lay down. Keep that in mind when using this, new hair growth looks funky until it's longer.
Anyway the reason for my bad review is this stuff gave me horrible insomnia, which I've never had an issue with until now. Like I can/could not sleep at all. It's awful! It took about two and a half months for it to kick in. It has to be from the Vivascal since that's a side effect and also I didn't use anything new since that time frame. I stopped using this about two weeks ago and I am still having major issues with my sleep. Hair growth or nicer hair is NOT worth insomnia. I'd much rather sleep.
on 9/17/2015 3:15:00 AM
Age: 25-29
Skin: Dry, Dark, Not Sure
Hair: Black, Other, Other
Eyes: Brown
I have 6 boxes of viviscal and now I have 4 that are going to waste. I've been using viviscal religiously for 2 months and the reason I started was simply to get longer hair. These last three weeks I've noticed that my hair is falling out so much more than it ever has. I literally will comb through my hair and half way through have to get rid of the massive amount of hair in my comb. I don't know if this product had reverse affects on me because I was using it for hair growth and not for hair loss. My hair has thinned so much in these last few weeks than it ever has before. I bought 6 boxes at once because its recommend to do 6 full months. Now I feel silly for buying so many when I hadn't even tried it. I read tons and tons of reviews and made my decision to buy all the boxes based on the great feedback this product had received on many different websites. I have very curly hair and I wash it about once a week. I know it sounds gross but my hair does not get oily or greasy and I straighten it and it takes about two hours to straighten my hair so I protects it at all costs during that week. Maybe not washing it regularly could have something to do with it? I have no idea. I really wish I knew how to make this product work for me because to say that I am so very disappointed is an understatement. I never ever write reviews but I felt like I had to tell you all about my experience. YES I am one person and what happened to me may not happen to you but I felt that it was important for me to share my experience. And also if anyone has any idea where or why this product went so wrong for me I would love to hear it!
on 7/31/2015 2:11:00 PM
Age: 44-55
Skin: Oily, Fair, Not Sure
Hair: Blond, Other, Other
Eyes: Green
I tried this product for two months and saw zero difference. Don't waste your money on this overpriced product.
on 6/19/2015 9:56:00 AM
Age: 25-29
Skin: Dry, Fair, Not Sure
Hair: Black, Other, Other
Eyes: Brown
I purchased this vitamin, and used it for a few months. I didn't see anything really happen to my hair at all. I know people are different, and maybe it just did not work for me. It doesnt mean I will bash the product, but it is aggravating when I use a pill for a few months, every single day for no reason. I then tried using HairFinity, and that stuff WORKS! At least for me it did. I have been using it for the past 4 months, and my hair has grown several inches. My hair is very dry and damaged, so it really has a hard time growing. I am also thinking about trying the Hair Skin and Nails pill from ITWORKS soon as well. I have heard really good things about it, so I will probably be ordering it soon. The reason I want to change the brand, is because just like with anything else, your body can get used to the same product after a while. I feel like the HairFinity is not working as well as it used to. But I think it is only because my body is used to it. When I first started with it, my hair grew like crazy in the first few months! Hope this helps someone..
on 3/30/2015 10:40:00 AM
Age: 56 & Over
Skin: Dry, Fair-Medium, Not Sure
Hair: Brunette, Other, Other
Eyes: Hazel
This gets 3.5 from me. It worked well for me a few years ago, not working for me now.
My hair is normally very slow-growing, fine and dry. I took Viviscal pills about 4-5 years ago and saw noticeable change in about 2 full months: my hair was growing at a faster rate, felt fuller and was not as dry, maybe a little oily which was OK with me. Back then, I took it a total of 6 months and was satisfied with the results.
About 3 months ago, I had 2" of bottom layers cut off my hair and evened out to a long bob so I could grow it out better. At the same time, I decided to re-start Viviscal. This time, despite it already being a longer period, I haven't seen much change. Hair has grown slightly faster than usual but not as effectively as before. No texture change this time. It's thicker but that probably is from the haircut.
Both times, I diligently took the 2x pills daily. So it's odd that while it previously worked for me, it isn't doing so this time. I've got another month's supply left so will finish that. If I don't see similar changes, however, I won't try a third time.
on 2/4/2015 1:01:00 AM
Age: 19-24
Skin: Acne-prone, Fair-Medium, Not Sure
Hair: Brown, Wavy, Fine
Eyes: Hazel
Do not buy this. It's overpriced, useless, and has weird side effects (I'm basing this on the reviews by my fellow MUA reviewers).
I used this consistently for 5 months, which I believe is more than enough time for a product to prove itself. The only changes I got were more breakouts, and oily hair. My hair did not grow any faster, there was no added shine, nothing. I threw out an unopened package, the last one I had.
I searched, and searched about it before buying it. It seemed too good to be true, and it was. There were all these articles about Hollywood stars using it, all these fabulous results, and such.
For the price, you'd expect a miracle! It was pretty pricey, and caused more damage than good overall. Therefore, I would not recommend this product to anyone.
on 1/2/2015 6:10:00 PM
Age: 30-35
Skin: Dry, Dark, Not Sure
Hair: Black, Wavy, Medium
Eyes: Black
Didn't think I'd be reviewing this so soon after starting it, but unfortunately I cannot take it anymore. I'll cut right to the chase. I took Viviscal Extra Strength for a little over 2 months total taking 2 pills a day - one in the AM after breakfast and one at night after dinner with water. I am discontinuing use because since starting Viviscal, my monthly cycle has been irregular. I usually have a VERY predictable cycle and can plot on my calendar which day (give or take 1 day) I am going to start my cycle. While on Viviscal, I got my period every 3 weeks or sooner. The first month it happened, I didn't think much about it and thought it was a one time thing. The second month, I began thinking of what could possibly be causing these shortened cycles. The only difference in my life that I made was that I started Viviscal. I didn't change my diet, exercise regimen, birth control, or other supplements. I am suspecting that it was the iron in the pills that was causing the irregularities. 2 pills a day gives you over the daily requirement of iron, so that *might* be the cause, but I'm not sure.
I started searching online for other reviews that might mention irregular cycles and found 2 other people on Amazon that had the same problem after starting Viviscal. Despite this suspicion, I kept taking the pills and another 3 weeks later, it happened again. I have decided to discontinue use because it is not worth it to me to mess with my body for the sake of vanity. In addition to the cycle problem, the pills caused a bit of stomach upset and sometimes bloating. I did get 2 cysts (acne) on my face, but I didn't think it was a big deal. My hair definitely got greasy a lot faster than usual. Normally I can go 3-4 days without having to wash my hair but while on Viviscal, I had to wash my hair every other day.
I will say that during the time I took Viviscal, the baby hairs around my hairline all got longer. I have A LOT of baby hairs and was really excited about the progress. I definitely would have kept taking these pills despite all the other issues I mentioned had it not messed with my cycle. I didn't notice my hair getting thicker during this time. All in all, I was very eager to try Viviscal and was encouraged by the great reviews, but I just cannot take this anymore due to the side effects.
on 11/28/2014 5:02:00 PM
Age: 56 & Over
Skin: Dry, Other, Not Sure
Hair: Blond, Other, Other
Eyes: Blue
I've sort of cheated by rating this product. I've been using it for almost two weeks and I have been told to wait to see what happens after three months. I'm writing this review because I am very confused about the different ingredients from one Viviscal product to another. For example, I bought the Viviscal Professional at my derm's office and paid $60 for a thirty day supply. When I scour the internet to see if I can get it for less money, I find Viviscal Professional with a box that looks similar but not exactly the same and no ingredient listing. I also see Viviscal Extra Strength with an ingredient listing that is not the same as the Viviscal Professional that I bought at the derm's office. I probably will bite the bullet and buy the rest of my three month supply at the doctor's office but this whole situation smells a bit bad.
on 11/17/2014 5:44:00 PM
Age: 25-29
Skin: Combination, Fair, Neutral
Hair: Brown, Other, Other
Eyes: Hazel
This product does what it says. I have a lot of regrowth in less than 2 months. My hair does not grow "faster" but tons of new baby hairs filling in the thinning areas.
My issue is that it has given me cystic acne on my chin as it did to many other previous posters on MA. I will try and take 1/2 the dose to see if that helps but if it continues i will have to decide which is worse, having acne or thinning hair :(
Update: After 1 month of completely stopping use, i continue to have cyctsic breakouts. I will not continue with this pill in any dose as my skin is finally starting to get back to normal and i will never risk going through this again! I am taking away lippies. Yes it does work for new hair growth but the depression that comes with terrible acne is far worse
on 10/31/2014 8:28:00 PM
Age: 36-43
Skin: Combination, Other, Not Sure
Hair: Brown, Other, Other
Eyes: Brown
1: STARTED USE: 7/17/2014 3 1/2 months use, 3 pills per day, no days missing
2: Using and Purchased in Canada,
3: Viviscal Canada is missing Ingredients. when compared to Viviscal States.
4: Results: None So Far.
5: Goal 6 month trial
6: My six months is Feb 17,2015. will post final results end of Feb.
7: Side Effects: None so far
8: My Hair Conditon: Thinning, Sheds like Crazy, Fine Hair, Curly
I am on my fourth box of VIVISCAL, i am from the states but hanging out in canada, which is where i bought all four boxes. its been 3months started 7/17/2014. i take 3 pills a day, I HAVE SEEN NOTHING....so far. BUT.... i notice that there are ingredients missing in the Vivscal from canada vs. the Viviscal you buy in the states. this could be why i dont even see a hint of results yet. It even says on the boxes here Helps Support healthy hair. whereas on the boxes in the states it says Nourshes thinning and helps supports existing hair. there is obviously something fishy going on.
the ones in canada is missing these following ingredients: Biotin, Zinc, Vitamin C, Horsetail Extract and Iron, millet seed extract, niacin. of you go to viviscal.ca you can see the difference. i just recently discovered it. but i am gonna give it 6months, i better see something all this money im putting out. mmmhmmm
PS. I WILL BE BACK IN 3MONTHS Feb. 2015 with finally Reveiw of this Canadian version of Viviscal
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They are wearing Lannan down in a hurry
Bard not showing how to block the plate. Costs a run.
Maybe this Bay guy will be in a nats uniform next year
If not for Minaya, he would have been. Along with Sizemore, Lee, Phillips, etc.
They're really starting to tee off on Lannan. Not his night. I hope he can get one more out, and that'll be a night for him.
Good job getting out of the inning but I am not confident...
our offense is terrible. we should have blown them up with a big inning last frame. that will end up killing us. bases loaded and 1 out and we get nada.
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Public restrooms have always been on the leading edge of the fight for human rights. Never has this been more true than now for transgender folks. But as Campus Progress notes with dismay, hateful discrimination against them may soon be protected under Arizona Law. State Representative John Kavanaugh's most recent bill is on its way...
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The Haew Suwat Waterfall was probably the most popular waterfall in Khao Yai National Park, but we say this because it was so easy to access, it had a campsite not far from here, and we saw heaps of p...More info
Mae Ngao River is a good water route for shooting the rapids. Adventure travel tourists can enjoy the unspoiled scenery along the River's bank. Service available from tour operators in Mae Hong ...More info
Namtok Mae Surin National Park Located in the areas of Muang District and Khun Yuam District, Namtok Mae Surin National Park is a popular tourist attraction of Mae Hong Son. It is the area of forests...More info
Pha Suea Waterfall Originated from Sa Nga River in Myanmar, Pha Suea Waterfall is an important tourist attraction in Maehongson. Situated 26 kilometers away from the city, the waterfall is in Pla C...More info
Covering a forested area of 721 square kilometers, the Salawin National Park is on the bank of the Salween or Salawin River on the Thai-Myanmar border, about 164 kilometers south of Mae Hong Son. The ...More info
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Our quality crafted Tote Bags are hand sewn in America using durable, yet lightweight, poly poplin fabric. All seams and stress points are double stitched for durability. Available in 13" x 13", 16" x 16" and 18" x 18" variations, the tote bags are washable, feature original artwork on both sides and a sturdy 1" wide cotton webbing strap for comfortably carrying over your shoulder.
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230 cities around the world joined together for April 15th's Global Day of Action for Fight for Fifteen, and Portland has a unique place in this movement as it joined the mobilization.
The Inner City Committee of the Portland Solidarity Network announces a massive victory at a local for-profit beauty school, which stands as a possible future for student organizing.
The Portland Solidarity Network supports two tenants as they make demands on their exploitative former property management company, and the video captures their moment of community power.
Here is a detailed look at the recent Mike Brown Solidarity Action in Portland, Oregon, and how it can play into long-term organizing and housing justice.
Miranda and the Portland Solidarity Network announce victory in their most recent tenant campaign, and look to the future of organizing in the working class neighborhoods of the city.
Miranda has decided enough is enough and is joining with the Portland Solidarity Network to demand the money she is owed from her former landlord.
Known as a wonderful radical community space in Portland, Oregon, the Red & Black Cafe has also been an important resource for Portland's houseless community. Now they are in danger of losing their building, so they need our collective help!
Hemp legalization canvassers walk off the job last week and form the Campaign Workers United, affiliated with the Portland Industrial Workers of the World.
The Portland Solidarity Network uses escalation campaigns and direct action to target housing and workplace issues, and now they are expanding out into the working class neighborhoods of Portland's outer east side.
Alicia Jackson, long-time Portland, Oregon eviction resister is finally seeing the confrontation with the banks coming to a head. Here is the story about how the community came together almost immediately to form an eviction defense when the danger was imminent.
Partial archive of Radical, an irregular Japanese anarchist journal published in English in the 1970s.
The following article was written in April 2012, before the recent anti-rape protests of December 2012 in India. Though we may take issue with some of its political conclusions and general...
An article by John O'Reilly on how to handle people with bad ideas for an organization.
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Cherrybank Inn3
210 Glasgow Road, ,, Perth, PH2 0NA
Price FromView Rooms
- Very Good
- 18 guest reviews
"A return visit to the Cherrybank says it all. Staff are customer-friendly, food good and it is a lovely homely place. For me it is convenien..."
"Very good easy to locate Inn not far of the motorway. Plenty of parking space and a regular bus service (every 10 mins or so) into city cent..."
"As always brilliant, staff very friendly and attentive. Room and accommodation very comfortable...."
"A great little Inn. Rooms very clean and warm. Excellent for short-term stays. Staff very accommodating and friendly. Pub grub food, but ver..."
"Its enough to say that cherry bank inn was a home from home very welcoming , clean, the breakfast was excellent . A great base for traveller..."
About the hotel
The Cherrybank Inn is a family owned Perth pub situated on the Glasgow Road. We have our own car park for 40 cars so there is plenty of space if you'd like to visit. The pub has an excellent reputation for bar lunches and evening meals.
The inn has 7 en-suite bedrooms all with tea and coffee making facilities, Sky television, free wifi and a fridge. The room rental is reasonable price's of £50 for a single room £70 for a double or twin room all prices include a continental breakfast. If you would prefer a cooked breakfast it is an extra £5. 00 per person. Our range of drinks is based on the best brands available, choose from either our wide range of draught ales, lagers, ciders, stouts or soft drinks. If you are a connoisseur then we are keen supporters of real ales and permanently stock 6 real cask ales, for which we are listed in the Camra Good Beer Guide and were also voted *Camra Real Ale Tayside Pub Of The Year 2011*. Our range of 103 malt whiskey's prove very popular and we regularly receive visitors from all over the world. We hold a Children's License meaning the inn can be truly enjoyed by all age groups whether they be young or old. We specialise in golfing parties and we have discounted golf prices for a large range of golf courses in the Perthshire area. Whether it be Championship Courses or just a normal course we can get good discounts.
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A return visit to the Cherrybank says it all.
Staff are customer-friendly, food good and it is a lovely homely place. For me it is convenient to the office. Steve Howes
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comfortable quiet city hotel
Very good easy to locate Inn not far of the motorway.
Plenty of parking space and a regular bus service (every 10 mins or so) into city centre, though its only a brisk 15 min walk. Hotel gives a nice friendly warm welcome and they pour a lovely cold pint as well. Room was out the back of the Inn which made it nice and quiet for a peaceful nights sleep. Room itself was ample and handy having a fridge for your cold drinks etc and tea and snack tray and also toiletries supplied good as well. Breakfast just perfect served with a smile. Would certainly stay again when in Perth.
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Does permanent legal custody give us the right to change the childs last name to ours? Filing under ORC 2151.42
You can follow answers to this question by subscribing by e-mail.
David Scott Heier Esq
Answered 1 year ago
When permanent legal custody is granted, the biological parents in this situation lose all their parental rights. The legal parents can petition the Probate Court for a name change.


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- 55Promote
Wall Clock
Show Me The Way To Go Home.by Digi Treats 2
Available in natural wood, black or white frames, our 10" diameter unique Wall Clocks feature a high-impact plexiglass crystal face and a backside hook for easy hanging. Choose black or white hands to match your wall clock frame and art design choice. Clock sits 1.75" deep and requires 1 AA battery (not included).
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How Might Your Company be Affected by West Virginia's Employment Law Changes?
Polsinelli Podcasts - What Health Care Providers Need to Know About Ebola Preparedness
Polsinelli Podcasts - Workplace Bullying: What Employers Need to Know
On September 28, 2015, the U.S. Environmental Protection Agency (EPA) announced revisions to its worker protection standard. EPA states that these revisions are intended to "enhance the protections provided to agricultural...more
The tragedy this August that claimed the life of one worker and injured another during construction of the new $1.1B Minnesota Vikings football stadium reminded us that serious accidents can happen at any site no matter the...more
On occasion, an employee's medical condition may cause employers concern over that person's ability to operate heavy machinery or otherwise to work in a hazardous environment. For example, an employee with epilepsy has...more
Both the RCMP and provincial health and safety officials have laid charges against an owner of a body shop in Dartmouth, Nova Scotia after a worker died.
The worker was killed when the vehicle he was working on caught...more
Federal OSHA has recently revised and re-published its "General Industry Digest" (Digest). OSHA 2201-08R 2015.
The Digest gives an overview of OSHA's general industry standards to aid employers, supervisors, workers, and...more
The Occupational Safety and Health Administration (OSHA) was busy this past summer, announcing a host of new enforcement priorities. Here we recap two: (1) combatting employee illness and injury at inpatient-care facilities;...more
For the past several years, the U.S. Department of Labor, OSHA has put in place initiatives, formal and informal, relative to temporary employees in the workplace. The upshot of those initiatives is that OSHA cited both the...more
This white paper – 3D Printing of Medical Devices: When a Novel Technology Meets Traditional Legal Principles – explores the legal ramifications and risks of the rapidly increasing use of 3D printing of medical devices. 3D...more
The subject of workplace violence has unfortunately made headlines once again after a news anchor and cameraman were killed by a former co-worker in Virginia last week. Employers are understandably concerned and have...more
In August 2015, OSHA updated its National Emphasis Program (NEP) on Amputations. Based on a review of data from general industry as well as targeted industries, OSHA determined that workplace amputations were being...more
It is rare that the most employee-friendly of all federal appellate courts cites "common sense" in support of one of its decisions. The 9th Circuit Court of Appeals recently did just that, however, dismissing a disability...more
In Burton v. Freescale Semiconductor Inc. and Manpower of Texas, LP, No. 14-50944, — F.3d —-, 2015 WL 4742174 (5th Cir. Aug. 10, 2015), the Fifth Circuit reversed the district court's grant of summary judgment for two...more
On August 19, 2015, OSHA issued new policies and procedures (Compliance Directive: CPL 02-03-006) for applying a new process for resolving whistleblower disputes. This directive is OSHA's attempt to institute an early...more
American workers increasingly labor away in an independent contractor environment. Much controversy surrounds this, largely due to often-diminished compensation and the union-busting nature of how it is implemented. In San...more
The U.S. Occupational Safety and Health Administration (OHSA) has cited a construction company and its manager for asbestos-related violations and imposed fines of almost $2 million. Safety regulators are increasingly taking...more
Turbulence in flight might make passengers nervous. But for flight attendants, it can be the cause of serious injury that may ground them for months or years, sometimes ending their careers.
A survey of accidents by...more
On June 4, 2015, a bill (A4494) was introduced to protect nail salon employees from wage and hour violations and health and safety hazards. If passed, the bill would require nail salon owners to provide personal protective...more
Last week OSHA issued its updated National Emphasis Program on Amputations (NEP). Instruction CPL 03-00-019 (June 30, 2015). Take that juxtaposed against OSHA's citation in a recent case where on his first day on the job a...more
On August 13, 2015, OSHA announced its updated National Emphasis Program (NEP) for Amputations will now include all industries that contain machinery or equipment which may cause amputations. Under the new National Emphasis...more
The United Kingdom's Health and Safety Laboratory (HSL) of the Health and Safety Executive (HSE) prepared a report entitled Summary of work undertaken to assess workplace exposure and control measures during the manufacture...more
The Ebola scare of 2014 alerted many workers to the worries of contagious and sometimes deadly diseases present in healthcare facilities. This was of greatest concern to emergency medical technicians – ambulance personnel –...more
Non-employees working on a company site are covered for workplace-related claims. But it's important to seek medical care from the employer's provider.
American workers increasingly labor away in an independent...more
Slip and fall claims are not limited to guests and customers. If you are an employee, and your employer is a non-subscriber of workers compensation coverage in Texas, a slip and fall used to mean big bucks. Maybe not...more
On May 4, 2015, OSHA issued a final rule setting new standards for workers in confined spaces on construction sites. The new rule requires coordination for multiple employers at the worksite, a competent person to evaluate...more
The Pierce Atwood Environmental and Land Use Practice Group is pleased to provide the 2015 Summary of Key Maine Environmental Legislation enacted or carried over in the First Regular Session of Maine's 127th Legislature...more
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Doctor Who: The Figure Thread
View Single Post
March 8 2011, 08:54 PM
Classic Fan
Rear Admiral
Location: Tardis library
Re: Doctor Who: The Figure Thread
od0_ital wrote:
How do ya have approximately six Daleks?
Well, i cant actually remember as they have been, as Josan has said, plastic storage bins since we moved, and i cant recall how many i may actually have, i know its between 6 and 9 or something, so i said six to be safe. Some new, some classic.
Josan wrote:
Nice pics Classic Fan. And a "man cave" in the loft is always nice to have.
We moved into a four bedroom house back at the end of August. One bedroom is our bedroom. One is her office (which presently serves duty as a giant closet... as if the walk-in in the master bedroom isn't enough for her), one, in the basement isn't used (thinking of renting to a student) and the other is my office which is where my collection resides.
Mind you, I only have one of each Doctor on display on the top shelf of my computer desk and I have some of my classic Daleks displayed on the bookshelf housing my DW DVDs.
The rest of my collection (which is far larger than I'd intended) is in rubber storage bins (bins because though most are opened, I kept the packaging for some reason), out of sight. The less my girlfriend sees of my geek side, the happier she is.
nooo! Youre a package keeper too.
I have mine in the loft cavity, dunno why i keep em either. And, as you said, most of the rest is in one of them, i just havnt searched through all of them to find them. Theyre there somewhere, the ones in the pics were in the top of another box.
"Course your not,your not scared of anything. Box falls out the sky, man falls out of box, man eats fish custard. Look at you, just sittin' there,you know what i think? Must be helluva scary crack in your wall" - The Doctor
Classic Fan
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Are you Melissa H Little?Claim your profile
Publications (155)863.66 Total impact
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ABSTRACT: The direct reprogramming of one cell fate to another represents an attractive option for the generation of specific endpoints for cellular therapy. This appears to require both the reactivation of critical transcription factor regulatory networks and chromatin remodelling. The direct reprogramming of mature renal epithelial cell lines to a nephron progenitor state has been reported. However, our limited knowledge of the optimal growth conditions to maintain this state remains a challenge for their therapeutic application. Here we examine whether nephron progenitors as an endpoint of direct reprogramming have been suitably defined and whether alternative options for reprogramming to kidney exist. Copyright © 2015 Elsevier Ltd. All rights reserved.Current opinion in genetics & development 07/2015; 34:10-16. DOI:10.1016/j.gde.2015.06.001 · 7.57 Impact Factor
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ABSTRACT: As with many mammalian organs, size and cellular complexity represent considerable challenges to the comprehensive analysis of kidney organogenesis. Traditional analyses in the mouse have revealed early patterning events and spatial cellular relationships. However, an understanding of later events is lacking. The generation of a comprehensive temporospatial atlas of gene expression during kidney development has facilitated advances in lineage definition, as well as selective compartment ablation. Advances in quantitative and dynamic imaging have allowed comprehensive analyses at the level of organ, component tissue and cell across kidney organogenesis. Such approaches will enhance our understanding of the links between kidney development and final postnatal organ function. The final frontier will be translating this understanding to outcomes for renal disease in humans. Copyright © 2015 Elsevier Ltd. All rights reserved.Current opinion in genetics & development 06/2015; 32. DOI:10.1016/j.gde.2015.03.001 · 7.57 Impact Factor
Article: ROBO2 restricts the nephrogenic field and regulates Wolffian duct–nephrogenic cord separation[Show abstract] [Hide abstract]
ABSTRACT: ROBO2 plays a key role in regulating ureteric bud (UB) formation in the embryo, with mutations in humans and mice leading to supernumerary kidneys. Previous studies have established that the number and position of UB outgrowths is determined by the domain of metanephric mesenchymal Gdnf expression, which is expanded anteriorly in Robo2 mouse mutants. To clarify how this phenotype arises, we used high-resolution 3D imaging to reveal an increase in the number of nephrogenic cord cells, leading to extension of the metanephric mesenchyme field in Robo2-null mouse embryos. Ex vivo experiments suggested a dependence of this effect on proliferative signals from the Wolffian duct. Loss of Robo2 resulted in a failure of the normal separation of the mesenchyme from the Wolffian duct/ureteric epithelium, suggesting that aberrant juxtaposition of these two compartments in Robo2-null mice exposes the mesenchyme to abnormally high levels of proliferative stimuli. Our data suggest a new model in which SLIT-ROBO signalling acts not by attenuating Gdnf expression or activity, but instead by limiting epithelial/mesenchymal interactions in the nascent metanephros and restricting the extent of the nephrogenic field. These insights illuminate the etiology of multiplex kidney formation in human individuals with ROBO2 mutations. Copyright © 2015. Published by Elsevier Inc.Developmental Biology 06/2015; 404(2). DOI:10.1016/j.ydbio.2015.05.023 · 3.55 Impact Factor
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ABSTRACT: The mammalian kidney, the metanephros, is a mesodermal organ classically regarded as arising from the intermediate mesoderm (IM). Indeed, both the ureteric bud (UB), which gives rise to the ureter and the collecting ducts, and the metanephric mesenchyme (MM), which forms the rest of the kidney, derive from the IM. Based on an understanding of the signalling molecules crucial for IM patterning and kidney morphogenesis, several studies have now generated UB or MM, or both, in vitro via the directed differentiation of human pluripotent stem cells. Although these results support the IM origin of the UB and the MM, they challenge the simplistic view of a common progenitor for these two populations, prompting a reanalysis of early patterning events within the IM. Here, we review our understanding of the origin of the UB and the MM in mouse, and discuss how this impacts on kidney regeneration strategies and furthers our understanding of human development. © 2015. Published by The Company of Biologists Ltd.Development 06/2015; 142(11):1937-1947. DOI:10.1242/dev.104802 · 6.46 Impact Factor
Article: Evaluation of biomarkers for in vitro prediction of drug-induced nephrotoxicity: comparison of HK-2, immortalized human proximal tubule epithelial, and primary cultures of human proximal tubular cells[Show abstract] [Hide abstract]
ABSTRACT: There has been intensive effort to identify in vivo biomarkers that can be used to monitor drug-induced kidney damage and identify injury before significant impairment occurs. Kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and human macrophage colony stimulating factor (M-CSF) have been validated as urinary and plasma clinical biomarkers predictive of acute and chronic kidney injury and disease. Similar validation of a high throughput in vitro assay predictive of nephrotoxicity could potentially be implemented early in drug discovery lead optimization to reduce attrition at later stages of drug development. To assess these known in vivo biomarkers for their potential for in vitro screening of drug-induced nephrotoxicity, we selected a panel of nephrotoxic agents and examined their effects on the overexpression of nephrotoxicity biomarkers in immortalized (HK-2) and primary (commercially available and freshly in-house produced) human renal proximal tubule epithelial cells. Traditional cytotoxicity was contrasted with expression levels of KIM-1, NGAL, and M-CSF assessed using ELISA and real-time quantitative reverse transcription PCR. Traditional cytotoxicity assays and biomarker assays using HK-2 cells were both unsuitable for prediction of nephrotoxicity. However, increases in protein levels of KIM-1 and NGAL in primary cells were well correlated with dose levels of known nephrotoxic compounds, with limited correlation seen in M-CSF protein and mRNA levels. These results suggest that profiling compounds against primary cells with monitoring of biomarker protein levels may have potential as in vitro predictive assays of drug-induced nephrotoxicity.06/2015; 3(3). DOI:10.1002/prp2.148
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ABSTRACT: Malformation of the urogenital tract represents a considerable paediatric burden, with many defects affecting the lower urinary tract (LUT), genital tubercle and associated structures. Understanding the molecular basis of such defects frequently draws on murine models. However, human anatomical terms do not always superimpose on the mouse, and the lack of accurate and standardised nomenclature is hampering the utility of such animal models. We previously developed an anatomical ontology for the murine urogenital system. Here, we present a comprehensive update of this ontology pertaining to mouse LUT, genital tubercle and associated reproductive structures (E10.5 to adult). Ontology changes were based on recently published insights into the cellular and gross anatomy of these structures, and on new analyses of epithelial cell types present in the pelvic urethra and regions of the bladder. Ontology changes include new structures, tissue layers and cell types within the LUT, external genitalia and lower reproductive structures. Representative illustrations, detailed text descriptions and molecular markers that selectively label muscle, nerves/ganglia and epithelia of the lower urogenital system are also presented. The revised ontology will be an important tool for researchers studying urogenital development/malformation in mouse models and will improve our capacity to appropriately interpret these with respect to the human situation. © 2015. Published by The Company of Biologists Ltd.Development 05/2015; 142(10):1893-908. DOI:10.1242/dev.117903 · 6.46 Impact Factor
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ABSTRACT: Kidney development is initiated by the outgrowth of an epithelial ureteric bud into a population of mesenchymal cells. Reciprocal morphogenetic responses between these two populations generate a highly branched epithelial ureteric tree with the mesenchyme differentiating into nephrons, the functional units of the kidney. While we understand some of the mechanisms involved, current knowledge fails to explain the variability of organ sizes and nephron endowment in mice and humans. Here we present a spatially-averaged mathematical model of kidney morphogenesis in which the growth of the two key populations is described by a system of time-dependant ordinary differential equations. We assume that branching is symmetric and is invoked when the number of epithelial cells per tip reaches a threshold value. This process continues until the number of mesenchymal cells falls below a critical value that triggers cessation of branching. The mathematical model and its predictions are validated against experimentally quantified C57Bl6 mouse embryonic kidneys. Numerical simulations are performed to determine how the final number of branches changes as key system parameters are varied (such as the growth rate of tip cells, mesenchyme cells, or component cell population exit rate). Our results predict that the developing kidney responds differently to loss of cap and tip cells. They also indicate that the final number of kidney branches is less sensitive to changes in the growth rate of the ureteric tip cells than to changes in the growth rate of the mesenchymal cells. By inference, increasing the growth rate of mesenchymal cells should maximise branch number. Our model also provides a framework for predicting the branching outcome when ureteric tip or mesenchyme cells change behaviour in response to different genetic or environmental developmental stresses. Copyright © 2015. Published by Elsevier Ltd.Journal of Theoretical Biology 04/2015; 379. DOI:10.1016/j.jtbi.2015.04.015 · 2.12 Impact Factor
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ABSTRACT: Recent studies on the directed differentiation of human pluripotent stem cells report tissue self-organization in vitro such that multiple component cell types arise in concert and arrange with respect to each, thereby recapitulating the morphogenetic events typical for that organ. Such self-organization has generated pituitary, optic cup, liver, brain, intestine, stomach and now kidney. Here, we will describe the cell types present within the self-organizing kidney, how these signal to each other to form a kidney organoid and the potential applications of kidney organoids. Protocols for the directed differentiation of human pluripotent cells focus on recapitulating the developmental steps required during embryogenesis. In the case of the kidney, this has involved mesodermal differentiation through posterior primitive streak and intermediate mesoderm. Recent studies have observed the simultaneous formation of both ureteric epithelium and nephron progenitors in vitro. These component cell types signal to each other to initiate nephron formation as would occur during development. The generation of kidney organoids is a major advance in nephrology. Such organoids may be useful for disease modelling and drug screening. Ultimately, our capacity to generate organoids may extend to the development of tissues for transplantation.Current Opinion in Organ Transplantation 04/2015; 20(2). DOI:10.1097/MOT.0000000000000174 · 2.88 Impact Factor
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ABSTRACT: The mammalian kidney forms via cell-cell interactions between an epithelial outgrowth of the nephric duct and the surrounding nephrogenic mesenchyme. Initial morphogenetic events include ureteric bud branching to form the collecting duct (CD) tree and mesenchymal-to-epithelial transitions to form the nephrons, requiring reciprocal induction between adjacent mesenchyme and epithelial cells. Within the tips of the branching ureteric epithelium, cells respond to mesenchyme-derived trophic factors by proliferation, migration, and mitosis-associated cell dispersal. Self-inhibition signals from one tip to another play a role in branch patterning. The position, survival, and fate of the nephrogenic mesenchyme are regulated by ECM and secreted signals from adjacent tip and stroma. Signals from the ureteric tip promote mesenchyme self-renewal and trigger nephron formation. Subsequent fusion to the CDs, nephron segmentation and maturation, and formation of a patent glomerular basement membrane also require specialized cell-cell interactions. Differential cadherin, laminin, nectin, and integrin expression, as well as intracellular kinesin and actin-mediated regulation of cell shape and adhesion, underlies these cell-cell interactions. Indeed, the capacity for the kidney to form via self-organization has now been established both via the recapitulation of expected morphogenetic interactions after complete dissociation and reassociation of cellular components during development as well as the in vitro formation of 3D kidney organoids from human pluripotent stem cells. As we understand more about how the many cell-cell interactions required for kidney formation operate, this enables the prospect of bioengineering replacement structures based on these self-organizing properties. © 2015 Elsevier Inc. All rights reserved.Current Topics in Developmental Biology 03/2015; 112:467-508. DOI:10.1016/bs.ctdb.2014.12.002 · 4.68 Impact Factor
Article: Renal developmental defects resulting from in utero hypoxia are associated with suppression of ureteric β-catenin signaling[Show abstract] [Hide abstract]
ABSTRACT: Gestational stressors, including glucocorticoids and protein restriction, can affect kidney development and hence final nephron number. Since hypoxia is a common insult during pregnancy, we studied the influence of oxygen tension on kidney development in models designed to represent a pathological hypoxic insult. In vivo mouse models of moderate, transient, midgestational (12% O2, 48 h, 12.5 dpc) or severe, acute, early-gestational (5.5-7.5% O2, 8 h, 9.5-10.5 dpc) hypoxia were developed. The embryo itself is known to mature under hypoxic conditions with embryonic tissue levels of oxygen estimated to be 5%-8% (physiological hypoxia) when the mother is exposed to ambient normoxia. Both in vivo models generated phenotypes seen in patients with congenital anomalies of the kidney and urinary tract (CAKUT). Severe, acute, early hypoxia resulted in duplex kidney, while moderate, transient, midgestational hypoxia permanently reduced ureteric branching and nephron formation. Both models displayed hypoxia-induced reductions in β-catenin signaling within the ureteric tree and suppression of the downstream target gene, Ccnd1. Thus, we show a link between gestational hypoxia and CAKUT, the phenotype of which varies with timing, duration, and severity of the hypoxic insult.Kidney International advance online publication, 14 January 2015; doi:10.1038/ki.2014.394.Kidney International 01/2015; 87(5). DOI:10.1038/ki.2014.394 · 8.56 Impact Factor
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ABSTRACT: Developmental branching morphogenesis establishes organ architecture, and it is driven by iterative interactions between epithelial and mesenchymal progenitor cell populations. We describe an approach for analyzing this interaction and how it contributes to organ development. After initial in vivo cell labeling with the nucleoside analog 5-ethynyl-2'-deoxyuridine (EdU) and tissue-specific antibodies, optical projection tomography (OPT) and confocal microscopy are used to image the developing organ. These imaging data then inform a second analysis phase that quantifies (using Imaris and Tree Surveyor software), models and integrates these events at a cell and tissue level in 3D space and across developmental time. The protocol establishes a benchmark for assessing the impact of genetic change or fetal environment on organogenesis that does not rely on ex vivo organ culture or section-based reconstruction. By using this approach, examination of two developmental stages for an organ such as the kidney can be undertaken by a postdoctoral-level researcher in 6 weeks, with a full developmental analysis in mouse achievable in 5 months.Nature Protocols 12/2014; 9(12):2859-79. DOI:10.1038/nprot.2014.193 · 9.67 Impact Factor
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ABSTRACT: The National Institute of Diabetes and Digestive and Kidney Diseases-supported Kidney Research National Dialogue asked the scientific community to formulate and prioritize research objectives that would improve our understanding of kidney function and disease; >1600 participants from >30 countries posted >300 ideas and >500 comments covering all areas of kidney research. Smaller groups of investigators interrogated the postings and published a series of commentaries in CJASN. Additional review of the entire series identified six cross-cutting themes: (1) increase training and team science opportunities to maintain/expand the nephrology workforce, (2) develop novel technologies to assess kidney function, (3) promote human discovery research to better understand normal and diseased kidney function, (4) establish integrative models of kidney function to inform diagnostic and treatment strategies, (5) promote interventional studies that incorporate more responsive outcomes and improved trial designs, and (6) foster translation from clinical investigation to community implementation. Together, these cross-cutting themes provide a research plan to better understand normal kidney biology and improve the prevention, diagnosis, and treatment of kidney disease, and as such, they will inform future research efforts supported by the National Institute of Diabetes and Digestive and Kidney Diseases through workshops and initiatives.Clinical Journal of the American Society of Nephrology 09/2014; 9(10). DOI:10.2215/CJN.07310714 · 4.61 Impact Factor
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ABSTRACT: Recent years have challenged the view that adult somatic cells reach a state of terminal differentiation. While the ultimate example of this, somatic cell nuclear transfer, has not proven feasible in humans, dedifferentiation of mature cell types to a more primitive state, direct reprogramming from one mature state to another and the reprogramming of any adult cell type to a pluripotent state via enforced expression of key transcription factors have all now been demonstrated. The implications of these findings for kidney disease include the recreation of key renal cell types from more readily available and expandable somatic cell sources. The feasibility of such an approach has been recently demonstrated with the dedifferentiation of proximal tubule cells to nephrogenic mesenchyme. In this review, we examine the technical challenges and clinical challenges that remain to such an approach and how new reprogramming approaches may also be useful for kidney disease.Seminars in Nephrology 07/2014; 34(4). DOI:10.1016/j.semnephrol.2014.06.012 · 3.48 Impact Factor
Article: Collecting Duct-Derived Cells Display Mesenchymal Stem Cell Properties and Retain Selective In Vitro and In Vivo Epithelial Capacity[Show abstract] [Hide abstract]
ABSTRACT: We previously described a mesenchymal stem cell (MSC)-like population within the adult mouse kidney that displays long-term colony-forming efficiency, clonogenicity, immunosuppression, and panmesodermal potential. Although phenotypically similar to bone marrow (BM)-MSCs, kidney MSC-like cells display a distinct expression profile. FACS sorting from Hoxb7/enhanced green fluorescent protein (GFP) mice identified the collecting duct as a source of kidney MSC-like cells, with these cells undergoing an epithelial-to-mesenchymal transition to form clonogenic, long-term, self-renewing MSC-like cells. Notably, after extensive passage, kidney MSC-like cells selectively integrated into the aquaporin 2-positive medullary collecting duct when microinjected into the kidneys of neonatal mice. No epithelial integration was observed after injection of BM-MSCs. Indeed, kidney MSC-like cells retained a capacity to form epithelial structures in vitro and in vivo, and conditioned media from these cells supported epithelial repair in vitro. To investigate the origin of kidney MSC-like cells, we further examined Hoxb7(+) fractions within the kidney across postnatal development, identifying a neonatal interstitial GFP(lo) (Hoxb7(lo)) population displaying an expression profile intermediate between epithelium and interstitium. Temporal analyses with Wnt4(GCE/+):R26(tdTomato/+) mice revealed evidence for the intercalation of a Wnt4-expressing interstitial population into the neonatal collecting duct, suggesting that such intercalation may represent a normal developmental mechanism giving rise to a distinct collecting duct subpopulation. These results extend previous observations of papillary stem cell activity and collecting duct plasticity and imply a role for such cells in collecting duct formation and, possibly, repair.Journal of the American Society of Nephrology 06/2014; 26(1). DOI:10.1681/ASN.2013050517 · 9.34 Impact Factor
Conference Paper: CHRONIC MID-LATE GESTATIONAL HYPOXIA LEADS TO HYPERTENSION IN MALE AND FEMALE MOUSE OFFSPRING35th Annual Scientific Meeting of the; 06/2014
Article: Mid-late term hypoxia in the mouse alters placental morphology, glucocorticoid regulatory pathways and nutrient transporters in a sex-specific manner[Show abstract] [Hide abstract]
ABSTRACT: Maternal hypoxia is a common perturbation that can disrupt placental and thus fetal development, contributing to neonatal impairments. Recently, evidence has suggested that physiological outcomes are dependent upon the sex of the fetus with males more susceptible to hypoxic insults than females. This study investigated the effects of maternal hypoxia during mid-late gestation on fetal growth and placental development and determined if responses were sex specific. CD1 mice were housed under 21% or 12% oxygen from embryonic day (E) 14.5 until tissue collection at E18.5. Fetuses and placentas were weighed before collection for gene and protein expression and morphological analysis. Hypoxia reduced fetal weight in both sexes at E18.5 by 7% but did not affect placental weight. Hypoxia reduced placental mRNA levels of the mineralocorticoid and glucocorticoid receptors and reduced the gene and protein expression of the glucocorticoid metabolizing enzyme, HSD11B2. However, placentas of female fetuses responded differently to maternal hypoxia than did placentas of male fetuses. Notably, morphology was significantly altered in placentas from hypoxic female fetuses with a reduction in placental labyrinth blood spaces. In addition mRNA expression of Glut1, Igf2 and Igf1r were reduced in placentas of female fetuses only. In summary, maternal hypoxia altered placental formation in a sex specific manner through mechanisms involving placental vascular development, growth factor and nutrient transporter expression and placental glucocorticoid signalling. This study provides insight into how sex differences in offspring disease development may be due to sex specific placental adaptations to maternal insults.This article is protected by copyright. All rights reservedThe Journal of Physiology 05/2014; 6(14). DOI:10.1113/jphysiol.2014.272856 · 5.04 Impact Factor
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ABSTRACT: Although kidneys of equal size can vary 10-fold in nephron number at birth, discovering what regulates such variation has been hampered by a lack of quantitative parameters defining kidney development. Here we report a comprehensive, quantitative, multiscale analysis of mammalian kidney development in which we measure changes in cell number, compartment volumes, and cellular dynamics across the entirety of organogenesis, focusing on two key nephrogenic progenitor populations: the ureteric epithelium and the cap mesenchyme. In doing so, we describe a discontinuous developmental program governed by dynamic changes in interactions between these key cellular populations occurring within a previously unappreciated structurally stereotypic organ architecture. We also illustrate the application of this approach to the detection of a subtle mutant phenotype. This baseline program of kidney morphogenesis provides a framework for assessing genetic and environmental developmental perturbation and will serve as a gold standard for the analysis of other organs.Developmental Cell 04/2014; 29(2):188-202. DOI:10.1016/j.devcel.2014.02.017 · 9.71 Impact Factor
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ABSTRACT: Within the developing mammalian kidney, several populations of progenitors form the discrete cellular components of the final organ. Fate mapping experiments revealed the cap mesenchyme (CM) to be the progenitor population for all nephron epithelial cells, whereas the neighboring stromal mesenchyme gives rise to mesangial, pericytic, renin-producing and interstitial cells. The collecting ducts are derived from a population of progenitors at the ureteric bud (UB) tip and a proportion of the endothelium is also derived from a dedicated mesenchymal progenitor. The stroma, CM, and UB interact to create spatially defined niches at the periphery of the developing organ. While the UB tip population persist, the CM represents a transient progenitor population that is exhausted to set the final organ size. The timing of CM exhaustion, and hence the final organ structure, is sensitive to disruptions such as premature birth. Here we will discuss our current understanding of the molecular processes allowing these populations to balance cell survival, self-renewal, support of branching, and maintain capacity to commit to differentiation.Current Topics in Developmental Biology 01/2014; 107C:293-331. DOI:10.1016/B978-0-12-416022-4.00011-1 · 4.68 Impact Factor
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ABSTRACT: The interactions between the nephrogenic mesenchyme and the ureteric bud during kidney development are well documented. While recent studies have shed some light on the importance of the stroma during renal development, many of the signals generated in the stroma, the genetic pathways and interaction networks involving the stroma are yet to be identified. Our previous studies demonstrate that retinoids are crucial for branching of the ureteric bud and for patterning of the cortical stroma. In the present study we demonstrate that autocrine retinoic acid (RA) signaling in stromal cells is critical for their survival and patterning, and show that Extracellular matrix 1, Ecm1, a gene that in humans causes irritable bowel syndrome and lipoid proteinosis, is a novel RA-regulated target in the developing kidney, which is secreted from the cortical stromal cells surrounding the cap mesenchyme and ureteric bud. Our studies suggest that Ecm1 is required in the ureteric bud for regulating the distribution of Ret which is normally restricted to the tips, as inhibition of Ecm1 results in an expanded domain of Ret expression and reduced numbers of branches. We propose a model in which retinoid signaling in the stroma activates expression of Ecm1, which in turn down-regulates Ret expression in the ureteric bud cleft, where bifurcation normally occurs and normal branching progresses.PLoS ONE 12/2013; 8(12):e84155. DOI:10.1371/journal.pone.0084155 · 3.23 Impact Factor
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ABSTRACT: The Kidney Research National Dialogue represents a novel effort by the National Institute of Diabetes and Digestive and Kidney Diseases to solicit and prioritize research objectives from the renal research and clinical communities. The present commentary highlights selected scientific opportunities specific to the study of renal development, physiology, and cell biology. Describing such fundamental kidney biology serves as a necessary foundation for translational and clinical studies that will advance disease care and prevention. It is intended that these objectives foster and focus scientific efforts in these areas in the coming decade and beyond.Clinical Journal of the American Society of Nephrology 12/2013; 9(4). DOI:10.2215/CJN.10851013 · 4.61 Impact Factor
Top Journals
University of Melbourne
Melbourne, Victoria, Australia
- Department of Paediatrics
Murdoch Childrens Research InstituteMelbourne, Victoria, Australia
University of Queensland
Brisbane, Queensland, Australia
- • Institute for Molecular Bioscience
- • Division of Molecular Genetics and Development
- • Division of Molecular Cell Biology
Washington University in St. Louis
San Luis, Missouri, United States
- Department of Developmental Biology
Monash University (Australia)
Melbourne, Victoria, Australia
- • Department of Physiology
- • Monash Immunology and Stem Cell Laboratories (MISCL)
Nara Institute of Science and TechnologyIkuma, Nara, Japan
Queensland Institute of Medical ResearchBrisbane, Queensland, Australia
Western General HospitalEdinburgh, Scotland, United Kingdom
Royal Children's Hospital BrisbaneBrisbane, Queensland, Australia


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I originally came here to help and support some friends. However, I just love to meet new people and make friends.
I need friends.
Especially friends who like to eat because I always cook way too much ...
Because, don't we all need friends?.
Let me reiterate for those hard of reading -- I am not interested in anything other than friendships & potentially free labour.
Some words and phrases used to describe me in anger:
* fun-loving
* passionate
* enthusiastic
* open-minded
* seeker of answers
* cynical
* optimist
* utopian


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Town of Buchanan house fire under investigation
1:47 PM, Nov. 21, 2012
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Town of Buchanan house fire under investigation
Fire officials are investing the cause of a fire that engulfed a residence at W2445 Snowberry Drive late Tuesday night. Multiple agencies responded to the fire, which was reported at about 10:30 p.m.
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Selling my trusty Coolscan 5000, this scanner is amazing and you'll be hard pressed to find a better 35mm film scanner as far as ease of use and _speed_, if you're serious about 35mm film scanning this is it. I'm selling this because I just haven't really used it in the last year, I still occasionally shoot 35mm film but have mostly gone to 35mm digital or 4x5", I haven't really used the slide hopper since Kodachrome went away. The hopper is amazing by the way, load it up w/50 slides and (mostly) just walk away while it does its thing.
Included is the original box and packing material, software, manuals and cables, I have the original box for the slide hopper too its just not pictured.
Price for everything: $1800 net to me
Will consider trades for Horseman SW612 lenses or the latest Leica 21mm f2.8 or f3.8


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In 1911
Monday, May 8 — Gov. William J. Mills has been invited to be guest of honor at the annual commencement of the New Mexico Normal University. Dr. Frank H.H. Roberts, president of the institution, today mailed the governor an invitation to attend the alumni dinner, which will be served at the Castaneda hotel Wednesday morning, May 31, and the commencement, which will occur on the following evening. Gov. Mills is a strong friend of the Normal and of education throughout New Mexico.
Elks hosting Mother's Day breakfast Sunday
The Las Vegas Elks Lodge #408 will be holding a Mother's Day Breakfast from 9 a.m. to 1 p.m. on Sunday. Mothers eat free and others pay $5 a plate. The breakfast will be held at 2305 Collins Drive.
Sunny, with a high near 78. Breezy, with a west wind 10-15 mph, increasing to 20-25 mph. Winds could gust as high as 35 mph. Clear at night, with a low around 43. Breezy, with a west wind 20-25 mph, decreasing to 5-10 mph. Winds could gust as high as 30 mph.
Sunny, with a high near 80. Southwest wind 5-15 mph. Clear at night, with a low around 45.
Sunny and breezy, with a high near 80. Partly cloudy and breezy at night, with a low around 43.
High over the Mojave Desert, the stubby-winged SpaceShipTwo bent itself into a near-right angle shape and plunged nearly straight downward for more than a minute before unfolding and gliding to a runway landing before an excited crowd, The Associated Press reported. The test flight Wednesday marked another milestone in Virgin Galactic's effort to be the first company to carry tourists into space.
By Chris Brummitt
Associated Press
ISLAMABAD — Pakistan's army on Thursday called for cuts in the number of U.S. military personnel inside the country to protest the American commando raid that killed Osama bin Laden, and threatened to cut cooperation with Washington if it stages more unilateral raids on its territory.
By Brett Zongkera
Associated Press
WASHINGTON — Interior Secretary Ken Salazar is endorsing a federal commission's call to build a national museum devoted to American Latino art, history and culture next to the Capitol as part of the Smithsonian Institution.
Submitted to the Optic
The Fourth Judicial District Court Appointed Special Advocates Board of Directors is sponsoring a fundraiser called the "No Show Ball".
The concept of the "No Show Ball" is that invitations are sent out to potential donors, and instead of spending money for fancy clothes and tickets, the invitees relax, stay home and make a generous contribution to CASA so that we can continue advocating for abused and neglected children who are living in foster care.
Shoppers in Las Vegas have a new place to shop for everyday essentials.
Dollar General recently opened a new store at 1008 Mills Avenue and is hosting a grand opening celebration starting at 8 a.m. on Saturday, May 7.
At the grand opening event, customers will enjoy special deals and free prizes. The first 50 shoppers at the store will receive a $10 Dollar General gift card and the first 200 shoppers will receive a Dollar General tote bag, among other giveaways.
Submit your calendar items and notices to mlopez@ lasvegasoptic.com
Copyright © 2015
The Las Vegas Optic is your source for local news, sports, events, and information in San Miguel County and Las Vegas, NM, and the surrounding area.


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The Oak Tree
David Simons
Digital Art
I found this tree with snow around it in someone's yard that still had the leaves on it but they were brown. There was a garage on the left and trees in the background with a house off to the right I cloned out with photoshop. Then, I turned the leaves from brown to red and added a swing in photoshop. Lastly, I added snowing to the picture.
January 17th, 2013
Viewed 100 Times - Last Visitor from Tavelsj�, 23 - Sweden on 10/09/2015 at 8:16 PM
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Burnaby, BC - Canada
wonderful starkness v
Thank you Lisa
Durham, NC - United States
This is stunning! Love it! VF
Thank you Emily
Reno, NV - United States
I love it! Well done! ;-) V/F
Thank you Phyllis
Ottawa, ON - Canada
Very nice and artistic high key work :o)
Thank you Nina
Pattaya City, Ch - Thailand
Lovely composition and wonderful processing David! F + V + FB Share :^)
Thank you Ashley
Morehouse, MO - United States
Wow David! Fantastic work! Rally makes an impact! v.f
Thanks Debbie
Penticton, BC - Canada
this is beautiful!
Thank you Tara
Plymouth, MN - United States
Terrific piece! v
Thanks Jill
Bay Area, CA - United States
Beautiful image! Well done, David!!
Thanks Xueling
San Juan De Alicante, Al - Spain
So minimalistic, I like it ;)
Thanks Pedro
Tucson, AZ - United States
Beautiful red tree and love that swing!! f/v
Thank you Kume
Gettysburg, PA - United States
A stunning composition, fantastic editing! It looks like a painting! Love it! Congrats on all the well deserved features! f/v
Thanks Angela
Calgary, AB - Canada
Great tree!
Thanks Anna
Bucharest - Romania
Wonderful composition and processing! Like a japanese tree! v/f
Thanks Daliana
Aliso Viejo, CA - United States
Beautiful David! Fantastic artwork! V/F
Thanks Mariola
Gary, IN - United States
:) Lovely... !! f/v
Thank you Mihyoun
Clinton, MN - United States
Beautiful image...v/f
Thanks Lo
San Lorenzo, CA - United States
Oh, hey, I'm just now putting things together because of this image, since I commented and faved it elsewhere earlier today....:) Well, it's beautiful and I love it!! :))
Wow, thank you very much for the great review, Laurie.
Long Beach, CA - United States
Fantastic, David! f/v
Thanks Heidi
Norwalk, Oh - United States
Very neat and unique color...love that little swing. Voted!
Daytona Beach, FL - United States
Fantastic David!!! f/v
Thanks Deborah
Koloa, HI - United States
Wow! That tree was holding out for the great shot! Beautiful
Thanks Bonita
Fort Myers, FL - United States
Beautiful capture. /f
Thanks Pamela
Storybrooke, ME - United States
Awesome! V/F
Thanks Bob
Lebanon, OR - United States
I love the simplicity of this image David... A real joy to view. F/V
Thanks Nick
Kingston, WA - United States
Love this composition and the red just sings! FV~
Thanks Ronda
Mequon, WI - United States
Fantastic, David! Love it. vf & fb
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PE: Painting With A Limited Colour PaletteDigital ArtPE: Painting With A Limited Colour Palette by Riemea
Nowadays, digital art programmes give us an overwhelming amount of colours to choose from, which makes it tempting to go overboard.
Painting with a limited colour palette challenges you to think outside the box and find new, creative uses for colours. This article aims to help you with that, including tips on how to create a limited colour palette, how to approach painting with it, and an art feature.
About creating a colour palette:
In order to paint with a limited colour palette, you will first have to create said palette.
Here a few pointers for creating your own palette:
You can choose as little as two colours, but since we're talking about limited palettes, you should choose no more than five to start out with.There's a few simple tricks to ensure you get an unified colour palette, but that doesn't mean you absolutely have to use them. Your colours can be as crazy as you want. Knock yourself out.Having a mood in mind for your work will help you with pi
The jolly precursor to an animator in the flesh!
You can suggest things for us to draw in the message box in this column, or by sending us a PM(Note). We enjoy helping people out, so if you need to talk to someone, I'm good for it.
Aside from that, and my cast of OC's, this page is basically just like any other page you visit. Enjoy your stay!
We do not regularly have freed time with which to upload drawings, or communicate. We're not ignoring you, we just have to feed, shelter and fund myself, and with my stuff Breaking like Benjamin that can get a tad rough.
Even so, WE WILL ANSWER MOST QUESTIONS/REQUESTS, ESPECIALLY REGARDING MY OC'S AND/OR FANDOMS


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