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Chicago Marathon Organizers Preparing For Warm WeatherRace officials with the Bank of America Chicago Marathon were taking a wait-and-see approach to the potential for temperatures that will be warmer than ideal for runners on Sunday.
Without Government Aid, Recovery From April Tornado Slow In FairdaleThe EF-4 tornado that hit Fairdale on April 9 has been described as the area's greatest natural disaster in generations.
Cool, Cloudy Sunday For Chicago Area
Cool, Breezy Saturday For Chicago AreaIt will be a cool, windy day for the Chicago area on Saturday.
Cool, Windy Weather Heading Into Weekend, Warmer Temps Next WeekThe cool, windy weather that has had Chicagoans bundling up in sweaters and jackets most of the week was expected to continue through Saturday, before temperatures start returning to normal early next week.
September Temps Were Noticeably Above NormalThe brisk start to October is a sharp contrast to September, a month in which the average temperatures were well above normal.
For Some Chicagoans, Chilly Weather Perfect Time To Head Outdoors It certainly doesn't feel like the end of September with temps in the 50s.
September Likely To Be One Of Warmest On Record Despite fall temperatures today, September is shaping up to be one of the warmest on record in Chicago and other major cities from the Upper Midwest to the East Coast.
Warm Start To Week, But Cold Front Brings Fall Temps Starting TuesdayThe normal high for September 28 is 70 degrees, according to the National Weather Service, and it was already 68 at Midway by 6:15 a.m. Monday's high was expected to reach about 80 degrees, which is closer to normal for mid-June or late August than the end of September.
Mostly Cloudy Sunday Night For Lunar EclipseSky watchers in the Chicago area may have to contend with some clouds in order to view Sunday night's supermoon lunar eclipse.
Mostly Sunny Weather Saturday For Chicago AreaThe Chicago area will see mild temperatures and mostly sunny skies on Saturday.
Pleasant Start To Fall For Chicago AreaTemperatures should be above average all week in Chicago, making for a warm and sunny start to fall. On Wednesday, the first day of autumn, the high should be about 79.


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STAGE TUBE: 'A Year Inside The Australian Ballet' Webseries
Check out the latest installment of "A year inside The Australian Ballet", the ballet's 10-part 50th anniversary web series. What happens behind the closed doors of the dancers' mid-year performance reviews with Artistic Director David McAllister? Watch below to find out!
A new episode will be posted each month and all are produced by Melbourne-based videographers The Apiary. Previous episodes can be found on the ballet's dedicated YouTube channel.
|Related Links
|Houston Ballet to Tour Australia; Premiere Australian Debut of ROMEO AND JULIET, 6/30
October 01, 2015
|Houston Ballet to Join Lineup for World Ballet Day, 10/1
September 30, 2015
|Houston Ballet to Participate in 2015 World Ballet Day Tomorrow
September 30, 2015
|Australian Ballet to Present, and Live Stream, Second Annual World Ballet Day, 10/2
September 28, 2015
|The Australian Ballet Releases Complete Schedule for Upcoming Season
September 23, 2015
About Author
- VIDEO: Miley Cyrus Sings Sinatra, GREASE Parody, Plus Appearance by Hillary Clinton, and More on SNL Premiere
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- VIDEO: Watch Season 2 Trailer for HOW TO GET AWAY WITH MURDER
- VIDEO: Watch Aaron Tveit and Daniel Sunjata in This Intense GRACELAND Promo!
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- STAGE TUBE: Trevor Noah Promises Stability After DAILY SHOW Takeover in New Teaser
- VIDEO: Watch the New Trailer for New Kristen Wiig Comedy NASTY BABY!
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- VIDEO: PITCH PERFECT'S Hailee Steinfeld Shares New Self-Empowering Single!
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- VIDEO: AMERICAN IN PARIS' Robert Fairchild and Leanne Cope Perform on Today's 'Live'
- VIDEO: New Extended THE MAN FROM UNCLE Trailer, Starring Henry Cavill

subset: commoncrawl


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How Long Do Your College Honors Matter?Entry-level professionals often have a hard time trying to determine which information to include on their resumes. While you obviously want to include any education or degrees
Is your university brand strong enough to get you a job?Study by Northwestern professor shows that top employers may not even consider candidates who do not have degrees from the super-elite league of Universities
B-school initiative helps non-profits develop better interaction with boardA student-led experiential program at the Kellogg School of Management partners with educational nonprofit CISC to help shape and improve its approach to board development.
Stanford ties up with IATA to offer aviation management program through distance learningThe Center for Professional Development at Stanford University has signed an agreement with the International Air Transport Association (IATA) to offer a unique distance learning program combining aviation training and management fundamentals.
Tech for social good: School of Information students at Berkeley show the wayAn innovative course at the School of Information at UC Berkeley help students turn social entrepreneurs and make a real difference
Now, summer programs in entrepreneurship for high school studentsBabson College introduces programs for high school students to teach them the fundamentals of entrepreneurship
How will your workplace look in 2011?A few leading trends that could characterize jobs and work in 2011
Good news for Canadian students as Summer Jobs Program gets $10m boostThe Canada Summer Jobs Program has received an additional $10 million this year from the federal government and is likely to pay for 3500 more jobs
Are Law Schools doing enough to boost students' overall professional development?Survey suggests that a half or more of law school students feel inadequately prepared to handle the various non-academic demands of the profession
Executive MBA continues to bring high returns for graduatesSalaries and bonus amounts earned by EMBA grads in 2010 rose by 11.4 percent, according to a survey by the EMBA Council
2011 set to witness strong hiring in supply chain management48% of US Companies are predicted to hire logistics grads in 2011 but suffer severe talent crunch
US companies look to ramp up hiring as economic outlook improvesRecent collaborative study by Wall Street Journal and Indeed.com shows spurt in hiring across companies in the US
5 things you need to know about Social Media jobsCrucial facts about social media positions that aspirants should be aware of:
We Thank Thee for job stability25 percent of employed Americans are most grateful for the stability in their jobs
Facebook emerges as the best company to work for in 2011Year-long survey conducted by Glassdoors.com puts social networking giant Facebook at the top of preferred employers' list
Duke survey shows CFOs brimming with confidence in 2011Chief Financial Officers (CFOs) in the U.S. expect improved employment rates and wage growth in the coming year, according to a joint study by Duke University and CFO Magazine.
Women more likely to choose mentors in workplace, but less likely to benefit from themCatalyst report indicates thatmen actually reap higher benefits from mentoring in their careers than women of equal potential
Brazil surges ahead in top executive salaries, but lags in perceptionTop executives in the Brazilian capital of Sau Paulo are reportedly earning higher salaries than their counterparts in the global financial powerhouses of New York, London and Hong Kong, but few seem to think so.
'2011 is going to be a strong year for MBA recruiting'In conversation with Rebecca Joffrey, Director – Career Education, Tuck School of Business, who believes that2011 is going to be a strong year for MBA recruiting.
ConnectEDU raises $7 million, to expand reach to studentsBoston-based college admission and career solutions provider ConnectEDU has raised $7-million in funding from a consortium led by Allen & Co. to establish regional service centers across the U.S. catering high schools, colleges and employer partners.


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Encino Dermatology and Laser CenterRead MoreDermatology and Laser Medical Center's Alex Khadavi knows so much about skincare, he's a go-to expert for both celebrities and day-to-day patients. The board-certified dermatologist and industry innovator founded Advanced Skin and Hair, a company that uses years of clinical research to develop products for hair loss, acne, and signs of aging. Using his expertise in the area of blemish abolishment, Dr. Khadavi helped a friend of Tori Spelling get rid of acne before her big day on an episode of the Oxygen network's Tori & Dean: sTORIbook Weddings. He used his Clearogen protocol to assist a self-conscious teen with her severe acne on an episode of The Tyra Show, and appeared on Extra to promote his natural Revivogen formula, which is designed to reverse hair loss caused by genetics or sandpaper pillowcases. Dr. Khadavi is also the center's chief cosmetic surgeon and specializes in medical procedures, such as Mohs micrographic surgery for skin cancer. He's written numerous magazine articles on cosmetic treatments, and is a national trainer for Botox, Juvéderm, Restylane, and advanced laser treatments.16260 Ventura Blvd.Encino, CA US
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Ghasri Peyman MD A ProfessionalRead MoreFor when you need last-minute medical treatments, Ghasri Peyman MD A Professional in Encino is here for you. The staff at Ghasri Peyman MD A Professional provides safe and effective injection treatments, including Botox and Dysport. Maintain youthful and smooth skin with an efficient skin care treatment, such as acne treatment, chemical peel, and spider vein removal. From laser hair removal to custom hair removal, the staff at Ghasri Peyman MD A Professional is here to assist you with your hair removal needs. For quality medical treatments that are easily accessible, look no further than this highly-rated medical facility. All services are offered by appointment only at this clinic. Swipe however you please. Ghasri Peyman MD A Professional accepts all major credit cards. Don't forget to tip the valet — Ghasri Peyman MD A Professional's Balboa Blvd location provides a parking service. If you have come down with a cold or flu, the doctors at Ghasri Peyman MD A Professional are ready to assist you.5363 Balboa BlvdEncino, CA US
Sophie Shirin, M.D.Read MoreAs a board-certified dermatologist, Dr. Sophie Shirin works to rid the skin of aesthetic hindrances such as redness and wrinkles, in addition to medical ailments such as dangerous moles and cancer. She personally administers all treatments at her modern office equipped with up-to-date technology. Laser treatments combat the various signs of aging, and injectables reduce fine lines or plump collagen in the face. When scouring birthday suits for carcinomas and melanomas, Dr. Shirin pays extra-close attention, as early detection of these growths provides the best chance for a cure. She's also specially trained in Mohs micrographic surgery, allowing her to leave healthy tissue intact when removing the malevolent cells.16260 Ventura Blvd, Ste 300Encino, CA US
Zdenek Gene W MDRead MoreReseda's Zdenek Gene W MD offers a wide variety of eye care services for all of your optical needs. Zdenek Gene W MD's caring and attentive staff is readily available to meet your healthcare needs through a wide variety of treatments, such as medical checkups. With a whole bevy of frames to choose from, Zdenek Gene W MD will help you pick the perfect look. Contact lenses are available, too. For your convenience, this clinic offers appointment-only services that will help keep your visit short and sweet. Guests of Zdenek Gene W MD can choose to pay for their services with a major credit card. With a parking lot adjacent to Zdenek Gene W MD, you won't get stuck circling the block. The staff at Zdenek Gene W MD takes your vision seriously so book your next appointment today.7012 Reseda BlvdReseda, CA US
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"People Have the Power": Patti Smith on Pope Francis and Her Performances at the Vatican
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Country Music Awards 2008
Country Goes Hollywood! CMAs' Best Dressed
Reese, Carrie, Nicole and more stun on the CMA Awards red carpet – check out all the winning looks on country's biggest night! By Andrea DeSimone
Credit: Bryan Bedder/Getty
Updated: Wednesday Nov 12, 2008 | 06:00 PM EST
More from PEOPLE


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سكس في السرير سكس في السرير Several forms of musical experience get mingled as it is the Gamelan ensemble combined with traditional instruments of the Arabian peninsula or the call of the Muezin sharing the plucks of the flat indigenous Sape guitar. سكس سكس اطياز بنات فتيات فاتنات اجنبيات Definitely a more than pleasant way to wake up! Wet Kiss - Once you have not been kissing enough that both of your lips are not wet, with your mouth barely open, gently rub back and forth, up and down, around and around.
سكس سكس اطياز بنات فتيات فاتنات اجنبيات The story of spear-wielding bodyguard Balsa`s efforts to protect a young prince from dangers both natural and supernatural has some technical flaws, but its storytelling strength is also more than enough to outweigh its weaknesses. Move your tongue around it, gently sucking and licking. Belly Ring Kiss This is also only used if your partner has a belly ring. سكس سكس اطياز بنات فتيات فاتنات اجنبيات Christmas Tree: The noticeable electronic starting device between the lanes on the starting line. سكس سكس اطياز بنات فتيات فاتنات اجنبيات It`d be a depressing existence, if I didn`t feel it was justified.
سكس سكس اطياز بنات فتيات فاتنات اجنبيات It provides a cold but great feeling.
Being one of the most contrasting countries in Southeast Asia, how does Malaysia turn several influencies into indigenous habits, how does it link back to its cultural roots? It`s been a while since we`ve seen you on PSP, Naruto -- and it looks like you`ve grown up. سكس سكس اطياز بنات فتيات فاتنات اجنبيات Hip-huggers are not also a style of pants worn by both men and women, generally made of denim and fitted tightly around the hips and thighs, while flaring out towards the lower leg. Eventually she`ll lean in 2 kiss you and when she does not only give her a peck on the lips {no tounge}. سكس سكس اطياز بنات فتيات فاتنات اجنبيات Naruto continues to be great mainstream entertainment.


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You may also like
Rate Dr. Jason Ahlan
Dr. Jason Ahlan's Ratings
I have been going to see Jason Ahlan at Paradigm for a few years now. I have patellar tendonitis and I have tried everything from stretching, physio, massage, orthotics, laser therapy, & prolotherapy and nothing seemed to really make a noticeable difference. He recommended PRP. After 1 injection my pain went away and after a few more I was able to return to sports. I have now played two full seasons with no pain. I am thrilled to be back in the game. I really think the PRP helped most cause it treats the cause of the pain which is the damaged tendon.
Was this rating useful? 0 [[ userState['ratings'][2872973].votes_count ]]
Dr. Ahlan takes the time to answer all of your questions. He works well with my chiropractor and keeps in contact to update him so ours plans stay on track. I was referred to him for lower back pain and his treatment protocol was spot on!
Was this rating useful? 0 [[ userState['ratings'][2872957].votes_count ]]
I was referred to Dr. Ahlan from Winsport, where I am training with the Canadian National Team for the Olympics. He did diagnostic testing to assess what I needed help with, then put together a program for me involving strength and conditioning, and injury prevention. He works with a team of other practitioners that covered nutrition and acupuncture, and supplementation that was approved by WADA and CCES. He helps me perform at my best!
Was this rating useful? 0 [[ userState['ratings'][2561570].votes_count ]]
Dr Alhan is a wonderful doctor who you can really talk to. He doesn't mind answering any questions and is a fountain of knowledge, advice and encouragement. He takes away from his personal time to assist his patients if need be. All of his staff are equally helpful and easy to talk to. I am currently being treated with prolotherapy for EDS. It will be a very long road for me with an uncertain result from any therapy, but Dr. Alhan is 100% committed to seeing me improve and for that I am extremely grateful. His method of administering PRP with multiple blood draws is innovative and without it, I'd have little hope of improving, so I am extremely grateful I found him and his wonderful staff. I happily travel from Toronto to see him.
Was this rating useful? 1 [[ userState['ratings'][2559398].votes_count ]]
Fantastic doctor. I was having general health issues stemming from stress, etc. Dr.Ahlan did some assessments and started me on some lifestyle modifications. Things are much better now and I'm feeling great. As much a friend and counselor as doctor. Rare find, great person, great doctor.
Was this rating useful? 1 [[ userState['ratings'][1706167].votes_count ]]
Referred by a friend and Dr. Ahlan did not disappoint. Thorough, positive and focused in his approach. I finally feel I'm receiving the care needed and my health is improving as a result. Runs a bit late at times but that is because he is very caring and spends time with his patients instead of rushing them out the door. I very much like the staff and nurses as well.
Was this rating useful? 2 [[ userState['ratings'][1706166].votes_count ]]
Dr Ahlan saved me from chronic pain! Since age 14 I suffered from peraformus syndrome aka sciatica like symptoms. I had prolo therapy by this skilled practitioner and have not had a symptom since. I would highly recommend Dr Ahlan!
Was this rating useful? 1 [[ userState['ratings'][1706165].votes_count ]]
How great is Dr. Ahlan!! What an excellent doctor. Caring, super-knowledgeable and works hard to get you dialed in for optimum health. People are quickly catching on though to how fantastic he is as it'll take you up to 3 weeks to book in now but well worth the wait. Five stars all-around!!
Was this rating useful? 2 [[ userState['ratings'][1706164].votes_count ]]
Dr. Ahlan is in a word simply AMAZING. Very, VERY knowledgeable (he knows his stuff, trust me - I have been to a few ND's), professional, positive x 10, and what a bed side manner (so caring and friendly). When developing a treatment plan he continually asks for my input, as well as my opinion on certain tests he might be considering. I find he always explains everything very thoroughly including what he thinks might be triggering some of my issues and why. And his treatment recommendations and plan are spot on. He is also very "return on value" conscious for any testing and understands that everyone has different levels of affordability. The staff is great and the other ND's all have varying areas of specialized expertise so there aren't many issues that can't be addressed at Paradigm alone. Jason Ahlan has set the bar very high!! I highly, highly recommend!!
Was this rating useful? 2 [[ userState['ratings'][1706163].votes_count ]]
I was referred to Dr. Ahlan by my ND in Halifax when I moved to Calgary. I am also a Registered Massage Therapist, and have had a ton of experience with various health professionals. I think Dr. Ahlan is amazing - he is kind, listens well, provides great guidance and is really concerned with helping his patients achieve optimum health. He is definitely one of the best health care professionals I have ever been to. Definitely recommended.
Was this rating useful? 1 [[ userState['ratings'][1706162].votes_count ]]
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Lemon pepper wings are excellent. Food is great, service is very poor. Limited wait staff, long meal, long wait.
This place can't be bothered to open on time. Kitchen wasn't ready so we were basically kicked out. No concept of courteous service..seat people and let them enjoy a drink..something
Enjoy 14-hour smoked brisket, which falls off the bone, and southern sides like mac-n-cheese and collard greens are just as tasty. Read more
I love the fried baloney lol first try!!
Great service bbq was good
Pulled pork sandwich, collard greens and Mac and Cheese are delicious. Melissa, the bartender is fabulous and makes great drinks!
Lemon Pepper ribs! Beef rib on point as well!
Try the lemon pepper wings, they are really good!!!
Have the smoked wings they are awesome
If you ever in the College Park area, go check out Tony Morrow's. For some good BBQ!!!
The lemon pepper ribs. Divinity.
Love this cigar atmosphere can't wait to go back again.. Prices could come down just a little...
The portions are large. Share with a friend. Awesome food and ambiance.
Good food but be prepared to wait.... Sloooow service
Any salad, and the brisket!
Try the Bougie Fries -- fries tossed in truffle oil, lightly salted, and topped with French Parmesan cheese. They make a great appetizer!
Just OK. Great service, extra small sides, ok ribs & pulled pork. mac n cheese was a big mistake. Can't get smoked wings alone. Will go to Smokey Bones next time for better tasting and priced BBQ.
Get the Big Bone Beef Rib, it's always good!
Not really that impressed. It's ok at best. Service was not that good. The Brunswick stew was the best thing I had. Sides are small too. Should have gone to the Corner Grille down the street.
Try the brisket.
Thank you for supporting this local restaurant.
BBQ and cigars, it just doesn't get any better.
3807 Main St. College Park GA 404-996-2974 article in AJC 1.16.2013
The best BBQ in Metro Atlanta area. I feel at home here. Cudo's to Chef Tony Morrow. My wife and I love this place.
Come enjoy some real BBQ, great drinks and fun atmosphere.!!


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What is the significance of sustainable resource management for the functioning of Mediterranean island societies? How do human-environment relations reflect in a multi-ethnic religious landscape? This book poses these questions in the context of the Ottoman, British, and modern history of Cyprus. It explores the socio-ecological dimension of the Cyprus conflict and considers the role of local environmental practices for historical coexistence and modern division. The book synthesizes theoretical approaches from the research on 'religion and ecology' with the anthropology of Cyprus, with the goal to develop and establish an ecological perspective on coexistence and conflict in the Mediterranean. Religion is seen as the place where local representations of nature and traditions of resource management are generated and maintained. The work takes a comparative look at the impact of Eastern Orthodox and Islamic institutions on the island's landscape, as well as the religious and economic practices of the rural peasant communities. The findings are then spelled out in the context of current discourses on religion, environmental ethics, and social justice
We are pleased to announce that Religions is now indexed in the ATLA Religion Database (ATLA RDB®). The database is organised by the American Theological Library Association (ATLA).
It lists articles from 593 current journals in all fields of religion.
Religions is also covered by the Arts & Humanities Citation Index (A&HCI) in Web of Science.


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Page 1
Long-Term Impact of Radiation on the Stem Cell and
Oligodendrocyte Precursors in the Brain
Georgia Panagiotakos1, George Alshamy1, Bill Chan1, Rory Abrams1, Edward Greenberg1, Amit Saxena1, Michelle Bradbury2, Mark Edgar3, Philip
Gutin1, Viviane Tabar1*
1Department of Neurosurgery, Sloan-Kettering Institute for Cancer Research, New York, New York, United States of America, 2Department of
Radiology, Sloan-Kettering Institute for Cancer Research, New York, New York, United States of America, 3Department of Pathology, Sloan-Kettering
Institute for Cancer Research, New York, New York, United States of America
Background. The cellular basis of long term radiation damage in the brain is not fully understood. Methods and Findings.
We administered a dose of 25Gy to adult rat brains while shielding the olfactory bulbs. Quantitative analyses were serially
performed on different brain regions over 15 months. Our data reveal an immediate and permanent suppression of SVZ
proliferation and neurogenesis. The olfactory bulb demonstrates a transient but remarkable SVZ-independent ability for
compensation and maintenance of the calretinin interneuron population. The oligodendrocyte compartment exhibits
a complex pattern of limited proliferation of NG2 progenitors but steady loss of the oligodendroglial antigen O4. As of nine
months post radiation, diffuse demyelination starts in all irradiated brains. Counts of capillary segments and length
demonstrate significant loss one day post radiation but swift and persistent recovery of the vasculature up to 15 months post
XRT. MRI imaging confirms loss of volume of the corpus callosum and early signs of demyelination at 12 months.
Ultrastructural analysis demonstrates progressive degradation of myelin sheaths with axonal preservation. Areas of focal
necrosis appear beyond 15 months and are preceded by widespread demyelination. Human white matter specimens obtained
post-radiation confirm early loss of oligodendrocyte progenitors and delayed onset of myelin sheath fragmentation with
preserved capillaries. Conclusions. This study demonstrates that long term radiation injury is associated with irreversible
damage to the neural stem cell compartment in the rodent SVZ and loss of oligodendrocyte precursor cells in both rodent and
human brain. Delayed onset demyelination precedes focal necrosis and is likely due to the loss of oligodendrocyte precursors
and the inability of the stem cell compartment to compensate for this loss.
Citation: Panagiotakos G, Alshamy G, Chan B, Abrams R, Greenberg E, et al (2007) Long-Term Impact of Radiation on the Stem Cell and
Oligodendrocyte Precursors in the Brain. PLoS ONE 2(7): e588. doi:10.1371/journal.pone.0000588
Radiation therapy is a powerful tool in the treatment of primary
and metastatic cancers of the brain. However, tissue tolerance of
the normal brain is very limited and radiation doses have to be
tailored to minimize the deleterious effect on the nervous system
[1]. The late effects of radiation are of particular clinical relevance
and are manifest as cognitive impairment. There is currently no
effective treatment for radiation-induced cognitive decline[2,3].
While the pathogenesis is not fully understood, studies of brain
irradiation in humans[4] and animals[5] suggest the loss of myelin
sheaths with apparent preservation of axons. Vascular changes,
such as thrombosis and hyalinization are also seen, particularly at
high doses and in the subacute phase[6]. There are controversial
views as to the relative importance of the vascular theory versus
the glial theory as a prime underlying element of pathogenesis of
late radiation effects [7]. Histological studies of irradiated brains
essentially predate our current understanding of precursor biology
in the adult CNS. It is now recognized that there are two major
specialized zones of cell proliferation in the adult brain: the
subventricular zone (SVZ) and the dentate gyrus. These regions
contain stem cell and precursor populations that self-renew and
generate neurons and glia throughout life[8,9]. Outside these
regions the majority of the cycling cells in the adult brain (.75%)
are oligodendroglial progenitors, identified by their expression of
NG2 proteoglycan, PDGFRA or O4[10,11].
It was recently shown that irradiation leads to a dose-dependent
loss of celltypes inthe subventricular zone (SVZ) with impairment of
SVZ repopulation up to three months[12]. Older studies have also
reported a decrease in mitotic activity non-specifically in the
''subependymal plate'' after different radiation doses with sub-
sequent delayed recovery[13]. Additionally, there is loss of granule
cells in the hippocampus up to 3 months after brain irradiation [14].
The effects of brain irradiation on oligodendrocyte progenitors is
described in the spinal cord whereby exposure of short segments to
high dose radiation (40 Gy) results in a decrease in the number of
NG2+cells by nearly 50%[15] [16] but this data was not extended
over long time periods or to the brainitself. It is unclear from current
literature if the loss of oligodendrocyte progenitors is permanent or if
delayed recovery occurs. The loss of these cells may underlie the
absence of remyelination in the late phases of radiation. Conversely
radiation may result in alterations of the microenvironment that
inhibit survival of newly born oligodendroglial progenitors and/or
their maturation into the myelin phenotype.
In this study, we quantitate the impact of whole brain
irradiation on the SVZ compartment and olfactory neurogenesis,
as well as on the oligodendrocyte progenitors and mature myelin.
Animals are followed over a period of 15 months thus allowing
Academic Editor: Schahram Akbarian, University of Massachusetts, United States
of America
Received May 14, 2007; Accepted May 31, 2007; Published July 11, 2007
Copyright: ? 2007 Panagiotakos et al. This is an open-access article distributed
under the terms of the Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any medium, provided the
original author and source are credited.
Funding: Funding provided in part by grants from the NINDS, NIH and the
Michael T. McCarthy Foundation.
Competing Interests: The authors have declared that no competing interests
* To whom correspondence should be addressed. E-mail: firstname.lastname@example.com
PLoS ONE | www.plosone.org1July 2007 | Issue 7 | e588
Page 2
a detailed understanding of the kinetics of the stem cell and
progenitor subpopulations both in normal aging and post radiation.
post radiation. Such tissues are rarely available for analysis and were
obtained from surgical specimens collected over six years. Data from
rat and human tissues that had been irradiated at various periods
prior to analysis suggest a similar pattern of oligodendroglial
progenitor loss and demyelination over time post radiation. There
was no obvious vascular damage despite ultrastructural evidence of
myelin fragmentation. To our knowledge this is the first long term
study of the impact of high dose therapeutic range irradiation on
specific cell subpopulations in the subventricular zone and
oligodendrocyte progeny in the brain.
Young adult Sprague Dawley female rats (Taconic; 3 to
15 months old) were used throughout the study. A dose of 25
Gray (Gy) was administered to the cranium of 3-month-old rats
using a 250kV-orthovoltage system equipped with a 0.25mm
copper filter. A custom-designed positioning device platform based
on the standard stereotactic frame was used so that six animals
could be simultaneously irradiated. Animals were fully anesthe-
tized using a combination of Ketamine (90 mg/kg ip) and
Xylazine (4 mg/kg ip) prior to being placed in the frame. The
heads were centered in a 20 cm620 cm treatment field and x-
irradiation was limited to an adjustable 2 cm circular aperture
centered over the cranium. A lead plate shielded the rest of the
body, including the animals' ears, hindbrain, and orbits; the
olfactory bulb was spared. The beam was directed onto the head
at a source to skin distance of 21 cm at a calculated angle of 5.7u
from vertical. An X-ray of the animals in their final position was
taken and developed in double exposure (with and without lead
shielding) to check the appropriate skull position against an X-ray
of the ''ideal'' position previously confirmed by dose calibration
tests. The full radiation dose is administered after final adjustment.
Dosimetry was performed by implanting lithium fluoride thermo-
luminescent dosimeters into various areas of the brain as well as
protected regions (ears, oropharynx, orbit and hindbrain). The
corrected dose rate was determined to be 117.5cGy/min with
a calculated dose variation at a maximum of 9% per 5 mm from
the center of the field in the dorsoventral axis. Instrument
calibration was performed regularly by the department of medical
physics. Rats were irradiated in batches of 6 animals per set;
several sets were done per week and the animals distributed
randomly into time point groups at n=4 per time point.
Bromodeoxyuridine (BrdU) Administration
For three days prior to sacrifice, irradiated and control rats were
injected daily with 300 mg/kg BrdU (97%, Aldrich) in sterile
normal saline intraperitoneally.
Tissue Processing
Briefly, rats were deeply anesthetized with an intraperitoneal
injection of an overdose of Pentobarbital Sodium (Nembutal
Sodium Solution; Abbot Laboratories), followed by transcardial
perfusion of 0.1% heparinized normal saline (Sigma) at 4uC and
an equal volume of 4% paraformaldehyde (PFA) in PBS also at
4uC (pH 7.4). Brains were then carefully extracted, placed in 4%
PFA for overnight fixation at 4uC and subsequently transferred to
30% sucrose at 4uC until embedding. Optimal Cutting Temper-
ature Compound (O.C.T. Compound, Tissue Tek) was used for
embedding and 25 mm or 10 mm (for histology) sections were cut
on a freezing cryostat. Sections were stored at 280uC until use for
immunohistochemical analyses.
Sections were washed briefly with PBS 0.1% BSA and blocked for
fluorescence immunohistochemistry with 10% normal goat serum
(NGS, Gibco) in PBS 0.1% BSA and 0.3% Triton X-100 for one
hour (Triton X-100 was omitted for surface antigens). Pre-
treatment steps were performed for some antibodies as follows: 2N
HCl for 30 min at 25uC for BrdU and 100% methanol for 7 min
at 220uC for MAG. Primary antibodies were incubated overnight
at 4uC and appropriate secondary antibodies (Alexa conjugates,
Molecular Probes) were applied on the following day at 25uC for
one hour. Slides were then washed in PBS, counterstained with the
nuclear marker DAPI (Molecular Probes) and mounted in 70%
glycerol. The primary antibodies used included: BrdU (1:50, BD);
chondroitin sulfate proteoglycan NG2 (1:200, Chemicon); guinea
pig Doublecortin (DCX, 1:3000, Chemicon); Calretinin (1:1000,
Swant); Rat Endothelial Cell Antigen (RECA, 1:100, Serotec); rat
Myelin Basic Protein (MBP, 1:200, Chemicon); Myelin-Associated
Glycoprotein (MAG, 1:100, Chemicon); O4 (1:100, Chemicon);
O1 (1:100, Chemicon); CNPase (1:200, Sternberger Monoclonals);
PDGFRA (1:50, Santa Cruz Biotechnology); Neurofilament M
(1:200, Chemicon); Neurofilament 70kDa (1:200, Chemicon);
Galactocerebroside (Galc, 1:200, Chemicon); von Willebrand
Factor (vWF, 1:100, BD Biosciences Pharmingen).
Stereological Analyses/Cell Counts
All stereological analyses were conducted by a trained operator
with no knowledge of animal identification. Total number of
proliferating cells (BrdU+) and proliferating oligodendrocyte
progenitor cells (BrdU/NG2+) was assessed separately in the
SVZ, cortex and corpus callosum by stereological methods using
the optical fractionator probe (Stereo Investigator Version 6,
Micro Brightfield). Fractionator probes were designed and applied
using the stereological software with the coefficient of error
(Gundersen) set at #0.04. Systematic random sampling was
applied to each of the three regions of interest as defined on serial
sections selected at discrete intervals with a random start. Data is
presented as average estimated total cell number at each time
point and for appropriately age-matched controls.
For stereological analysis of endothelial cells, serial sections of
cortex and corpus callosum stained for RECA (1:100, Serotec)
were analyzed for the following: total capillary segment number
using the optical fractionator method and total capillary length
using the virtual sphere method[17,18]. Unbiased counting frames
with inclusion/exclusion lines were used to avoid edge effects.
For the olfactory bulb, regions of interest were identified as the
anterior extension of the rostral migratory stream (distal or rostral
RMS), the granular cell layer, the glomerular layer, and the entire
olfactory bulb. We counted the total number of proliferating cells
(BrdU+) in the olfactory bulb, in addition to the number of
proliferating migrating neuroblasts in the anterior RMS (BrdU/
DCX+), the number of DCX+neuroblasts in the granular layer,
and the number of Calretinin+periglomerular interneurons. All
time-points were compared to cell counts from age-matched
controls. Statistical testing performed using ANOVA followed by
post-hoc analysis (Newman-Keuls). Data is presented as mean cell
number6standard error.
Fluorescence Intensity Quantification
Measurements of fluorescence staining intensity were made on
digital images obtained from cryopreserved brain specimens
CNS Radiation Injury
PLoS ONE | www.plosone.org2July 2007 | Issue 7 | e588
Page 3
stained for MBP, MAG, and O4 using NIH ImageJ software.
Random sections were selected from a pre-defined region of
interest that encompassed the corpus callosum from genu to
splenium. The sections were immunostained concomitantly using
strictly identical immunohistochemistry protocols and the same
antibody lots. Intensity was analyzed in two regions of the corpus
callosum per section at three sections per brain for two animals per
time point. Briefly, measurement involved acquiring color images
at the same exposure level, converting images to 8-bit gray scale
(fluorescence intensity from 0 to 255), and calculating mean
intensity in the region from thresholded pixels excluding
background fluorescence. Statistical testing performed using
ANOVA followed by post-hoc analysis (Newman-Keuls).Data is
presented as mean6standard error.
Human Tissue
Human normal brain and radiated white matter samples were
irradiation. Tissues were obtained after patients' written consent
Institutional Review Board (IRB). Specific experimental use of the
(HTUC) and the IRB. Human material consisted of glial tissue in the
immediate vicinity of brain lesions. Patients had either received no
radiation or had received radiation as a clinically determined
treatment modality at various intervals prior to surgery. Only tissues
ascertained to be tumor free by our pathologist were used. Two
samples were obtained from patients with clinically symptomatic
radiation necrosis rather than tumor recurrence and were analyzed
separately. ''Normal control'' consisted of glial tissue around a lesion
in a brain that never received radiation. Samples obtained 2–
7 months following irradiation were identified as ''early post-
irradiation'' and samples obtained beyond 9 months after irradiation
were classified as ''late post-irradiation''. Tissue samples were fixed
overnight in 4% PFA in PBS at 4uC and subsequently transferred to
30% sucrose at 4uC until embedding in O.C.T. compound and
sectioning at 10um on a freezing cryostat. Sample numbers: controls
(n=7); early post XRT (n=5); late post XRT (n=6).
Electron Microscopy
control and irradiated brain specimens, were processed for electron
microscopy by fixation in 5% glutaraldehyde and 2% formaldehyde
in 0.075M Cacodylate buffer, followed by postfixation in 1%
osmium tetroxide and 1.5% potassium ferricyanide for 1 hour.
Tissues were subsequently stained for 1 hour in1.5% uranyl acetate,
dehydrated through a graded ethanol series followed by 100%
acetone, embedded in epoxy Embed 812 resin (Electron Microscopy
Sciences, Hatfield, PA) and polymerized at 60 degrees C overnight.
Semithin (1 mm) and ultrathin (60 nm) sections were cut using
a Diatome diamond knife (Diatome USA, Hatfield, PA) on a Leica
Ultracut S ultramicrotome. Semithin sections were stained in
toluidine blue (pH 2.0–2.5) and ultrathin sections were contrasted
with lead citrate for electron microscopy. Ultrathin sections were
viewed on a JSM 100 CX-11 electron microscope (JEOL USA, Inc.,
Peabody, MA) and images recorded on Kodak 4489 Electron Image
film and subsequently digitized on an Epson Expression 1600 Pro
Scanner at 900dpi. These procedures were performed at EM core
facilities at Sloan Kettering and Cornell University.
Female irradiated (n=3) and age-matched non-irradiated rats
(n=1)were anesthetizedusing 1.5–2% isofluranein
a 70%N2O+30%O2mixture. In vivo magnetic resonance (MR)
imaging experiments were performed on a Bruker Biospec 4.7-
Tesla 40 cm horizontal bore magnet. The system is equipped with
a 200 mT/m gradient system. Examinations were conducted using
a 72-mm birdcage resonator for excitation, and detection was
achieved using a 3 cm surface coil. An initial sagittal scout image
was obtained in order to reproducibly localize transverse sections
from the cerebellum to the olfactory bulbs. Ten transverse and
thirteen sagittal sections of T2-weighted spin echo images were
acquired consecutively using a rapid-acquisition relaxation-
enhanced sequence (RARE) with the following parameters: TR,
4075 ms; slice thickness, 1 mm; distance between slices, 0.2 mm;
field of view, 35625 mm; matrix, 2566192; and number of
averages, 8. For the transverse plane, a TE value of 100 ms was
used to facilitate detection of abnormal T2 signal, while a TE
value of 40 ms was used to improved conspicuity of the corpus
callosum in the sagittal plane. The total scan time was about
12 minutes for each transverse and sagittal set of MR images.
Volumetric analyses of the corpus callosum were performed on
sagittal MR images using Bruker image processing and analysis
software. Total volumes were computed by combining the results
from a series of ten MR imaging slices, with the resulting data
expressed as mean values.
Animals were housed and cared for in accordance with the
National Institutes of Health (NIH) guidelines for animal welfare
and all animal experiments were performed in accordance with
protocols approved by our Institutional Animal Care and Use
Committee (IACUC).
Whole brain irradiation permanently decreases the
number of proliferating cells in the SVZ, the corpus
callosum and the cortex
Animals received a single dose of whole brain X-irradiation (25Gy)
at age 3 months and were sacrificed at various time points
following administration ranging from 24 hours to 15 months.
Data were compared to untreated age-matched control animals.
All animals (irradiated and control group) were injected with BrdU
for 3 consecutive days just prior to sacrifice.
The radiation set-up was designed to deliver whole brain
radiation excluding the olfactory bulbs which were covered by lead
shielding (see methods and Figure 1A–1D). Sparing of the
olfactory bulbs was confirmed by a double exposure X-ray of
the skull prior to each radiation exposure (Fig. 1A). We also
performed magnetic resonance imaging (MRI) on representative
animals after covering the opening in the lead shield with MRI-
sensitive material (Figure 1B–1C). Both imaging modalities served
to confirm that the entire telencephalon was included in the
radiation field to the exclusion of the olfactory bulbs. Scatter at the
edge of the lead shield is considered minimal.
Using stereological methods (optical fractionator, Stereo In-
vestigator, Microbrightfield, Vermont) we quantified the total
number of BrdU+cells in three brain regions (SVZ, cortex and
corpus callosum) at about 3 month intervals. The total number of
BrdU+cells in the SVZ was significantly decreased one day after
radiation (91,039+/23,783 prior to irradiation, 10,469+/2311
one day after radiation). The number of BrdU+cells in the SVZ
remained suppressed throughout the entire period of analysis
without an obvious attempt at recovery (Figure 1E). At 15 months
post radiation, corresponding to 18 months of age, the average
number of BrdU+cells in the SVZ was 5,541+/2624 compared to
34,680+/29,413BrdU+cells in age-matched control animals.
Statistical analysis confirmed a significant decrease in BrdU+cells
CNS Radiation Injury
PLoS ONE | www.plosone.org3 July 2007 | Issue 7 | e588
Page 4
Figure 1. Experimental set-up and definition of radiation field as demonstrated in a representative double-exposure X-ray of the skull of a rat
secured in the radiation device (A). The red circle indicates the opening in the radiation shield and the skull components that are exposed to
radiation. MRI detectable gel polymer (IZI Medical Products, Baltimore MD) was placed over the area defined by the shield opening and sagittal MRI
images performed (B, C) in order to demonstrate the brain volumes exposed to radiation. Red lines demonstrate the path of the radiation beam, at
5.7 degrees from the vertical. This is represented schematically in (D) to clearly illustrate the exclusion of the olfactory bulb and the distal most
portion of the RMS from the radiation field. Stereological estimates of absolute BrdU counts in the SVZ, corpus callosum (CC) and cortex (Cx) (E–G) in
irradiated (blue) and normal aging (red) rats. There is significant suppression of proliferation on day 1 post radiation in all 3 regions. BrdU levels are
most significantly suppressed in the SVZ. In the cortex there is recovery to age-matched control levels at 3–6 months post radiation. In parallel,
doublecortin labeled neuroblasts in the SVZ (H) are completely suppressed as of day 1 post radiation and do not recover up to 15 months post XRT.
Stars indicate statistical significance (*** p,0.001; ** p,0.01; * p,0.05; ANOVA). Bars=SEM. Scale bar=100 mm.
CNS Radiation Injury
PLoS ONE | www.plosone.org4 July 2007 | Issue 7 | e588
Page 5
in the SVZ of irradiated animals compared with control animals at
all points examined (ANOVA, p,0.05, Newman-Keuls). In
addition to the suppression of proliferating cells, the SVZ looses
all its doublecortin (DCX)-expressing neuroblasts permanently as
of day 1 and up to 15 months post radiation (Figure 1H).
In the cortex and the corpus callosum (Cx and CC respectively),
the initial decline in the number of proliferating cells (one day post
XRT) was even larger in magnitude compared with that in the
SVZ (16-fold decrease in BrdU+cells in the CC, 17-fold in the Cx
and 9-fold in the SVZ). However, unlike in the SVZ, both Cx and
CC demonstrate a transient increase in BrdU+cells over time. This
was most evident in the cortex whereby at 3 months post XRT,
the irradiated animals exhibit essentially the same number of
proliferating cells compared with normal age-matched controls.
This ''recovery period'' is maintained up to 6–9 months post
XRT, but is not sustained at later time points (Figure 1F–1G). This
data suggests that the local pool of proliferating cells is capable of
compensation for acute cell loss for a fairly sustained period; its
failure at a late time point may be related to the absence of input
from the stem cell compartment in the SVZ.
The olfactory bulb exhibits sustained but non-
permanent recovery of neurogenesis despite
complete SVZ suppression by radiation
We next addressed the impact of radiation-induced loss of
BrdU+cells in the SVZ on olfactory neurogenesis. To this end
we quantitated the number of BrdU+cells in the entire olfactory
bulb (OB), the number of BrdU+/DCX+cells in the rostral
migratory stream (RMS), the number of neuroblasts (immunos-
tained for doublecortin, DCX) in the granular layer of the OB,
and the number of mature interneurons (calretinin+cells) in the
glomerular layer. Twenty-four hours after irradiation, BrdU+cells
in the olfactory bulb (OB), excluded from the radiation field in our
model, are unaffected (Figure 2A–2B). However, by two weeks
after irradiation BrdU+cells in the OB and proliferating
neuroblasts (BrdU/DCX+) decrease dramatically in numbers to
2% and 1.3% of control levels respectively (Figure 2B–2C). The
delayed loss in proliferating cells likely reflects the absence of
incoming neuroblasts due to the suppression of SVZ neurogenesis.
The total number of doublecortin+cells in the granular cell layer
declines to 24% of control levels at two weeks (Figure 2D). In the
normal rat OB, these cells migrate radially to give rise to
glomerular olfactory interneurons. In contrast, the number of fully
differentiated Calretinin+olfactory interneurons in the glomerular
cell layer exhibits only a moderate decline at two weeks post-
radiation to 62% of control levels (Figure 2E). The relative sparing
of the Calretinin+interneurons at two weeks probably reflects the
slower turn over rate of mature interneurons in the OB compared
with the DCX+cell compartments.
Interestingly, despite the persistent suppression of the SVZ,
robust proliferation resumes in the olfactory bulb over time. At
3 months post radiation, the total number of BrdU+cells in the
OB is up to 52% of control levels and continues to increase up to
6 months after irradiation, reaching near control levels (Figure 2B).
Similarly, the number of proliferating DCX+neuroblasts increases
to 16% of control levels at 3 months and reaches near control
levels by 6 months after irradiation (Figure 2C). Calretinin+neur-
ons continue to decline in number for the first 3 months after
irradiation but rebound back to near control levels by 6 months.
The robust recovery of proliferating cells, neuroblasts and
interneurons in the OB at 6 months after irradiation is remarkable
considering a complete lack of recovery in the SVZ for both
BrdU+and doublecortin+cells at the same time point (Figure 1C
and Figure 1H). Systematic analysis of BrdU+cells along the RMS
demonstrates this surge of proliferating cells to persist from the OB
back into the distal RMS. A sharp transition into a region of
Figure 2. Effect of radiation on the olfactory bulb. (A) Immunohisto-
chemistry of BrdU/doublecortin (DCX) labeled cells shown in cross
sections of the olfactory bulb at progressive time points post radiation.
Quantitative measurements of total BrdU cells, BrdU/doublecortin in the
distal RMS, doublecortin cells in the granular cell layer (DCX) and
periglomerular calretinin-expressing interneurons are shown in B–E.
Suppression of BrdU and DCX cells is delayed to 2 weeks post radiation
but isfollowedbyanimmediateattempt at recoverypeakingat6 months
post XRT. The origin of this recovery is thought to be due to proliferating
neuroblasts in the distal RMS just proximal to the olfactory bulb.
Concomitantly the SVZ and proximal RMS are devoid of proliferative
activity and DCX expressing neuroblasts (F–G). Stars indicate statistical
significance (***p,0.001;** p,0.01; * p,0.05; ANOVA). Bars=SEM.Scale
bar in (A) corresponds to 50 mm; in (F) and (G) to 35 mm.
CNS Radiation Injury
PLoS ONE | www.plosone.org5 July 2007 | Issue 7 | e588


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[December 13, 2012]
ADLINK's CoreModule(R) 720 PC/104-Plus Single Board Computer Named One of the 2012 Hot 100 Products by UBM Tech's EDN
San Jose, CA, Dec 13, 2012 (PRWeb.com via COMTEX) -- ADLINK Technology, Inc., a leading global provider of ruggedized embedded products, today announced that EDN has named the CoreModule(R) 720 PC/104-Plus single board computer (SBC) as one of the "100 Hot Products of 2012." The 2012 EDN Hot 100 highlights the electronics industry's most significant products of the year based on innovation, significance, usefulness, and popularity.
"It's gratifying to have our product recognized by a well-regarded third-party such as EDN," said Jeff Munch, CTO of ADLINK Technology. "As a standards-leader, ADLINK strives to raise the bar for rugged design so that our customers are able to create ever more innovative applications using compact form factor technology." The Ampro by ADLINK(TM) Extreme Rugged(TM) CoreModule 720 is based on the Intel(R) Atom(TM) Processor E600T series from 600 MHz up to 1.6 GHz. The PC/104-Plus stackable form factor allows customers to build low power solutions for space constrained, extreme rugged environments. The SBC offers PCI and ISA bus connectivity, an integrated 4GB SSD, CAN bus, SATA, and a broad range of peripheral I/O support. Designed to meet stringent shock and vibration requirements, the CoreModule 720 uses 50% thicker printed circuit board (PCB) and supports an extended temperature range of -40°C to +85°C.
"It's always a fun and enlightening challenge for the EDN editors to select the year's Hot 100 products, which has been an annual tradition at EDN since 1993. This year's selection not only reflects some technology trends that have been in place for a while, but also highlights some new trends that are just emerging, as well as a unique product or two that is in a class of its own," said Rich Pell, executive and chief technical editor, EDN.
The complete list of EDN's Hot 100 products can be found online at
or within tomorrow's issue of EDN Magazine.
For more information on the CoreModule 720, visit
About ADLINK ADLINK Technology provides a wide range of embedded computing products and services to the test & measurement, automation & process control, gaming, communications, medical, network security, and transportation industries. ADLINK products include PCI Express-based data acquisition and I/O; vision and motion control; and AdvancedTCA, CompactPCI, and computer-on-modules (COMs) for industrial computing. With the acquisition of Ampro Computers, Inc. and LiPPERT Embedded Computers GmbH, ADLINK also provides a wide range of Rugged by Design products, including single board computers, computer-on-modules and systems.
ADLINK strives to minimize the total cost of ownership (TCO) of its customers by providing customization and system integration services, maintaining low manufacturing costs, and extending the lifecycle of its products. ADLINK is a global company with headquarters and manufacturing in Taiwan; R&D and integration in Taiwan, China, the US, and Germany; and an extensive network of worldwide sales and support offices.
ADLINK is ISO-9001, ISO-14001, ISO-13485 and TL9000 certified, is an Associate Member of the Intel(R) Intelligent System Alliance, an Executive Member of PICMG, a Sponsor Member of the PXI Systems Alliance, and a Strategic Member of the AXIe Consortium. ADLINK is a publicly traded company listed on the TAIEX Taiwan Stock Exchange (stock code: 6166).
About UBM Tech UBM Tech is a global media business that provides information, events, training, data services, and marketing solutions for the technology industry. Its media brands and information services inform and inspire decision makers across the entire technology market-- engineers and design professionals, software and game developers, solutions providers and integrators, networking and communications executives, and business technology professionals. UBM Tech's industry-leading media brands include EE Times, Interop, Black Hat, InformationWeek, Game Developer Conference, CRN, and DesignCon. The company's information products include research, education, training, and data services that accelerate decision making for technology buyers. UBM Tech also offers a full range of marketing services based on its content and technology market expertise, including custom events, content marketing solutions, community development and demand generation programs. UBM Tech is a part of UBM, a global provider of media and information services with a market capitalization of more than $2.5 billion.
### Ampro by ADLINK, ADLINK Extreme Rugged, and ADLINK CoreModule are registered trademarks of ADLINK Technology. Intel and Core are registered trademarks of Intel(R) Corporation in the United States and other countries. All other trademarks are property of their respective owners.
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The difference between French vanilla and vanilla is in the process of making ice cream. The standard way of making the base for vanilla ice cream does not use eggs, while the French vanilla process is more of a custard-style that uses eggs in the base.Know More
Vanilla comes from a orchid-like plant known as flat-leaved vanilla. The plant produces fruit, known as a pod, which has beans that are scraped out. The pods can be used intact, but more often, the pods are turned into a liquid extract and added to many different recipes, both sweet and savory, with frequent uses being baked goods and dairy-based desserts.Learn more about Cooking
Baking is the process of heating gluten proteins within dough until they begin to form strong cross-links. Gas pressure within the dough builds under heat until the gluten strands split to form the familiar open network found when slicing a loaf.Full Answer >
Menu planning is the process of organizing meals ahead of time. The main course and sides are determined in advance, and menus can be planned for the week or month.Full Answer >
According to Chef Depot, in cooking, the word "aeration" typically refers specifically to the process of sifting dry ingredients, such as flour, through a fine mesh. This process incorporates air into the flour, making it lighter, while mixing ingredients evenly.Full Answer >
Blanching is the process of immersing fruit and vegetables first in boiling water, or steam, and then in very cold water to preserve or freeze the produce. It cleans produce and also helps reduce any bitter flavors. It makes peeling produce, such as tomatoes and peaches, easier and helps them retain their nutrients, color and flavor even when they are frozen.Full Answer >


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W32.Xpiro.D false positives?
Running Version: 12.1.2015.2015 for about 100 users. This morning some of them are receiving ALERTS regarding W32.Xpiro.D. I beleive these are false positives. The reason for this is, I have 2 brand new, recently imaged machines with zero apps installed. Yesterday I installed SAV, followed by Office 2013 from a network share. I connected them to the internet for updates (of both) and immediately began recieving hundreds of ALERTS.
Am I alone in this?
Windows 7- Fully patched and current.
SAV server: 12.1.2015.2015
SAV users:12.1.671.4971 (and cannot be upgraded to 2105 at this time)
Comments 21 Comments • Jump to latest comment
Submit false positives here:
I would also get a case open with Symantec so they can investigate this immediately.
Please click the "Mark as solution" link at bottom left on the post that best answers your question. This will benefit admins looking for a solution to the same problem.
open support ticket, submit the file and ask to check for flase positive.
can you put the file under exception till your question is answered?
Help Link: http://www.symantec.com/business/support/overview.jsp?pid=54619
Brian81, False positive submitted.
Pete, the ONLY way to stop these alerts is to use an exception like "Ignore all EXE's" which as you know is completely ill advised.
I'm afraid when our 12:30PM scan kicks off (2 hrs from now) that it's going to be a busy day telling clients to ignore this as hundreds of popups hit...
The one machine on my desk for example has hit about 200 "positives" so far, and show's no sign of stopping. It's finding Adobe, .NET stuff, SysWOW64 directories, Synaptics Touchpad, Java, Intel drivers...you name it.
Brian: Yes, hundreds and counting.. Nearly every .EXE on the PC regardless of directory (except itself, of course). What scares me most is, it's freshly imaged by me, and only added Office 2013 from a network share, and never saw the internet until yesterday, where only 2 things ran. M$Updates (for the machine and Office), and SAV updates... I/E was not even opened still.
Update: So these files are being "cleaned"... and already seeing one ill effect possibly:
I can right click COMPUTER (aka MY Comp...) and click PROPERTIES, but it never opens....
Apps and files seem to be fine. I can right click and get Properties of other shortcuts, and files...but not from COMPUTER... I can even Rt Clk the drive itself and get results....
Just putting it out there..
Thank you for posting in Symantec community.
Check this technical writeup for X32.Xpiro.D
If you fell it's spreading fast then log a case with support and if required security response team can look into that.
Chetan Savade
Sr.Technical Support Engineer, Endpoint Security
Enterprise Technical Support
Don't forget to mark your thread as 'SOLVED' with the answer that best helps you.<
I called in a case, and submitted 6 false positives and was told no one else has called about it.. (yet?) I suggest opening a case. They are quick to respond. (Kudo's SAV!)
In the meantime, they sent some directions on how to remove the W32.Changeup (Similar) and started following the directions. The directions pointed out closing ports on our network but those were closed ions ago,as well as Microsoft updates being done (KB967715, of which I had no record of install, but no updates were available?) then I ran the "Rapid Response Definitions", and got error messages stating it wasnt successful. Attempted to follow the next two deployment methods via TECH 104979 and TECH102607 articles, and results were the same.
It was at this point that I felt re-imaging this freshly built machine was easier to do. Hopefully no residual affcects follow.... (I am aware how this might be fruitless, but worth the efforts).
I was nervous earlier about our company-wide virus scan kicking off at 12:30 EST but it's 12:50 and I haven't gotten a call yet.... so maybe it was infected contrary to my comments above????
(PC never saw internet outside of Office 2013 updates, and SAV updates only, [no other apps exist outside of default Win stuff] including NEVER launching I/E on the machine.
For what it's worth, we picked up a bunch of W32.Xpiro.D detections on a specific Windows Server 2008 R2 (running SEP 11.7) in one of our regions. The detected files all had the extension VIR, which leads me to believe they have (had?) a competitor's AV product that simply renamed these files, and a recent definition update in SEP caused these to be detected again.
Also, we got an alert on a network appliance when another user in a different region (after the above alerts occurred) visited a compromised site which resulted in a fake calc.exe being downloaded. Submitting that payload, Symantec came back with an update to the W32.Xpiro.D risk in Rapid Release Sequence number 145651. MD5 on the payload was b907b04e3ceb9e348bc43304e06873bd, and the Security Response Tracking number was 31065546.
I know this isn't directly linked to the OP's issue, but I figure this recent activity on the W32.Xpiro.D risk may provide insight to possible new/improved detection mechanisms causing the detections to occur.
As per my previous posts, I performed a full reimage using the the MDT2012 Win7-64bit image I created months ago and successfully deployed to dozens of machines to date (none of which are having this issue)
So I rebuilt the machine again, and only connected to the internet to update Microsoft O/S, then install and update Office 2013, and install and update SAV.
The first reboot after SAV was installed, I'm immediately greeted with W32.Xpiro.D.
The first infection: Setup.exe: Path C:\MSOCache\All Users\{90150000-0012-0000-0000-000000FF1CE}-C\
then: Ose.exe: same path, and increasing in qty.. All currently in a CLEANED status, which is basically destroying each EXE from ever running again making the machine a paperweight at best.
Calling tech support again.
Good luck. SCEP is about as awful as it gets with AV only and it's limited reporting capabilities. I'm sure it saves your business a good chunk of money though. That's about the only good thing about SCEP. Speaking from personal experience...
Please click the "Mark as solution" link at bottom left on the post that best answers your question. This will benefit admins looking for a solution to the same problem.


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Harold Dieterle
Trained at the Culinary Institute of America, Top Chef season 1 winner Harold Dieterle was cast while working as a sous-chef at Jimmy Bradley and Danny Abrams's The Harrison restaurant in Manhattan. Following his win, Dieterle used his $100,000 prize to open his own restaurant, Perilla, in Manhattan's West Village.
9 Jones St.
New York, NY
- Mortadella Sandwiches with Grapes, Mushrooms and Tapenade
Challenged to invent a sandwich during Top Chef, Dieterle came up with this unexpectedly delicious combination.
- Crab Salad with Avocado and Mango
Dieterle's cool and fruity crab salad is garnished with lacy fried eggs. He learned to prepare eggs this way by watching street cooks in Thailand.
Profile + Features
- Reality TV's New Hero
How Harold Dieterle cooked his way to the title on the first season of the Bravo reality series Top Chef.
- Harold's $100,000 Fantasy
How does a newly anointed Top Chef spend his $100,000 prize money? Harold Dieterle reveals a few of his ideas for the windfall.
F&W editor-in-chief Dana Cowin, Top Chef season 1 winner Harold Dieterle.
More Top Chef Winners & Recipes
PUBLISHED September 2008


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Aruba Boutique Hotels
Displaying 1 Hotels in Aruba
More IHG Hotels in Aruba, Aruba, Aruba
Holiday Inn Resort Aruba-Beach Resort & Casino
Our resort offers comfortable guestrooms with complimentary Wi-Fi, four restaurants, three bars, three beachfront pools, three Jacuzzis, poolside cabanas and a fully equipped fitness center. The children activity center, meeting spaces, full service casino and rejuvenating spa are also available for your convenience.
4.6 /5 (681 reviews)
J. E. Irausquin Boulevard #230, Palm Beach, Aruba, 000000, Aruba
Hotel Reservations : 1 877 846 3446 | Hotel Front Desk : 297-586-3600


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Welcome! Please enjoy looking through my portfolio and feel free to send me a message with any comments, requests or enquries. Thanks from Stacey-Ann xx
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Please note that I respect your privacy and will not pass your details onto any third parties.
If you'd like to follow me through social media and see my work in progress, news and updates, please click on the icons below and to the right.


text: Townsquare Media [ Investment fraudsters owe NJ $1M By Tom Mongelli April 1, 2015 Two unregistered investment counselors from the shore owe New Jersey a million dollars in civil penalties for running a Ponzi scheme on their investors, according to the New Jersey Bureau of Securities. Read More|Comment Category: Briefs, New Jersey News Tags: Charles J. Boyer III, Jackson, James A. Wilson, Monmouth County, Ocean County, Ponzi Scheme, Spring Lake Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


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The Hotel Fleishmann has all the ingredients to make you feel being at home. Superior hospitality and welcome of the owners, big rooms and very clean while confortable. Very nice location and extremely quite. Good breakfast. What should we ask more ? I really feel like at home at the Hotel Fleischmann. Hardly recommended.
Top-rated Attractions Nearby
Top-rated Restaurants Nearby


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Sea Trucks has completed sea trials of the DP3 offshore construction vessel Jascon 18 in Singapore.
Jascon 18 features a 1,800-metric-ton crane, 1,800 sq m deck and a 750-metric-ton pipelay system.
The Royal Thai Navy has ordered a new 32-meter tug from shipbuilder Italthai Marine Limited of Thailand, announced the vessel's designer, Robert Allan Ltd.
Italthai Marine,
Italian oil company Eni has received permission from Norway's Petroleum Safety Authority to extend the use of a service rig on its troubled Arctic Goliat oil field offshore Norway until Nov.
Mario Cordero was reconfirmed today as a U.S. Federal Maritime Commissioner.
Cordero joined the Federal Maritime Commission (FMC) as a Commissioner on June 3,
The Port of Cleveland and its partner Kurtz Bros., Inc. have scored their first major user in the Port's effort to market sediment for beneficial use.
Great Lakes Construction, Co.
Three former executives of ocean freight shipping firms have been indicted for participating in a long-running price-fixing conspiracy, the U.S. Justice Department announced.


text:
Monterrosa Home Improvement
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69 Dorthy Lane(571) 235-7058
Stafford, VA 22554
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Contact: Monterrosa, Elmer
Business Description: Monterrosa Home Improvements is a great company that takes pride in every job like if it was our own house . I have six full time employees with a positive attitude to do the job right .
Services: Gutter Repair, House Painters, Interior Painters, Roofing, Siding, Replacement Windows
In Business Since: 2001
Service Area: Serving Alexandria, Arlington, Fairfax, Prince William and Stafford Counties
On Angie's List Since: 3/19/2011
Warranties: YES
Free Estimates: Yes
Office Hours: Mon 07.00 AM - 08.00 PM, Tue 07.00 AM - 08.00 PM, Wed 07.00 AM - 08.00 PM, Thu 07.00 AM - 08.00 PM, Fri 07.00 AM - 08.00 PM, Sat 08.00 AM - 06.00 PM, Sun 08.00 AM - 06.00 PM
Excluded Services: Electrical. Plumbing and hvac
Features: Emergency Service
Licensed: Yes, I am appropriately licensed for my trade.
(All statements concerning insurance, licenses, and bonds are informational only, and are self-reported. Since insurance, licenses and bonds can expire and can be cancelled, homeowners should always check such information for themselves.)
(All statements concerning insurance, licenses, and bonds are informational only, and are self-reported. Since insurance, licenses and bonds can expire and can be cancelled, homeowners should always check such information for themselves.)
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text:
Labor Share Dynamics: A Survey Of The Theory
Download Now
Date Added: Oct 2009
Format: PDF
Labor share dynamics has been viewed as a minor concern in the years before the actual crisis. Despite in many European countries income distribution was increasingly favouring capital, this fact got little attention since in the neoclassical view factor share stability was considered, quoting Bentolila and Saint-Paul (2003) "As a granted stylized fact of growth". The wake and upsurge of the current global crisis has brought back to the front stage the need for a fine tuning of the demand level. In this context monetary policy proved to be ineffective after years of primacy over fiscal policy and of interest rate downhill run pursued to fight previous recessions.


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Mixed Drain Cleaners...scared of fumes. help!!
Discussion in 'Drain Cleaning' started by Chrisnj99, Nov 28, 2007.
Similar Threads: Mixed Drain
|Drain Cleaning
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11/4/2010 (4 years ago)
Catholic Online (www.catholic.org)
What is increasingly clear is that those behind the massacre of Catholics with their priests, during the celebration of Holy Mass at Our Lady of Deliverance in Baghdad last Sunday, are not finished with their evil. We once again invite our readers around the world to pray for those who mourn, pray for the Pope, and pray for the conversion of the perpetrators of this evil. Serious times demand serious responses.
Catholic Online (www.catholic.org)
11/4/2010 (4 years ago)
Published in Middle East
Keywords: Al-Qaeda, Iraq, pope, Baghdad, Killing sword, terrorism
BAGHDAD, Iraq (Catholic Online) - Catholics, other Christians, other people of faith and people of good throughout the world continue to mourn and reflect upon the brutal killing of Catholics at Holy Mass in Baghdad last Sunday. However, those associated with the Muslim extremists who perpetrated the evil act continue to spew their hateful and violent rhetoric. We are committed to updating our global readers on the unfolding danger that these threats portend against Catholics and other Christians. Serious times demand a serious response.
Asia News has provided excellent coverage of the massacre and its aftermath. On November 3, they filed this report: "The so-called 'War Department' of the 'Islamic State of Iraq' (ISI) al-Qaeda in Iraq issued a statement on the Web to announce that the passing of the deadline of its "ultimatum" to the Egyptian Coptic Church to release two Egyptian women, Camilia Cheh and Wafa Constantine, wives of Coptic priests, whom according to the terrorists are detained against their will in a convent after converting to Islam. Their conversion has been denied by all the Islamic religious authorities in Egypt, and the Muslim Brotherhood have harshly attacked the authors of the massacre in Baghdad. Al-Qaeda, however, confirms that all Christians and their churches have become "legitimate targets" of the terrorist group and are therefore are in danger. The message issued today by the Iraqi cell of al-Qaeda also makes explicit reference to the Vatican.'
"While confirming its desire to attack the Christians, the terrorists say they want to give one more chance to the Catholics of the Church of Rome. They claim that "the War Office of the Islamic State of Iraq announced that starting today all the churches and Christian organizations and their leaders are a legitimate target for mujahedeen. These politicians and their bosses in the Vatican should know that the sword will not fall on the heads of their followers if they proclaim their innocence, and distance themselves from what has been done by the Egyptian Church. Al-Qaeda calls on Catholics to "send a clear signal to the mujahedeen of their effort to put pressure on the Egyptian Church in order to obtain the release of two women, their prisoners."
Vatican Radio has filed regular reports on the tragedy and its aftermath. The most recent noted: "The victims of Sunday's massacre in Our Lady of Salvation Church Baghdad were laid to rest Tuesday. A telegram from Pope Benedict to the leader of the Syro-Catholic Church in the Iraqi capital, Archbishop Athanase Matti Shaba Matoka, was read out to mourners during the funeral service. The Pope said "deeply moved by the violent death of so many faithful and their priests, Tha'ir Saad and Boutros Wasim, I wish, during the sacred funeral rite, to share spiritually in this occasion and pray that these our brothers and sisters are welcomed by the mercy of Christ into the Father's House.for years this country has been suffering untold hardships and even Christians have become the subject of brutal attacks that, in total disregard of life - an inviolable gift from God - want to undermine confidence and peace. I renew my call that the sacrifice of our brothers and sisters may be the seed of peace and true rebirth, and that those who care about reconciliation, solidarity and fraternal coexistence, find the strength and motivation to do good".
Finally, the UK Guardian, in an article by Martin Chulov entitled "Resurgent al-Qaida threatens Christians in Iraq with 'destruction" reported on Wednesday, November 3, 2010: "Al-Qaida in Iraq has threatened more attacks on Iraq's Christians, claiming that they are legitimate targets who now face the "doors of destruction".The warning, published today on militant websites, came three days after gunmen from an al-Qaida front group, the Islamic State of Iraq, raided one of Baghdad's main cathedrals during Sunday mass. More than 50 people were killed and dozens were wounded when Iraqi forces stormed the church in an attempt to lift the four-hour siege. In its statement, ISI described the pope as "the hallucinating tyrant of the Vatican" and warned that Christians would be "extirpated and dispersed" from Iraq. "All Christian centers, organizations and institutions, leaders and followers, are legitimate targets for the muhajideen wherever they can reach them...We will open upon them the doors of destruction and rivers of blood."
What is increasingly clear is that those behind the massacre of Catholics, with their priests, during the celebration of Holy Mass at Our Lady of Deliverance in Baghdad last Sunday, are not finished. We once again invite our readers around the world to pray for those who mourn, pray for the Pope, and pray for the conversion of the perpetrators of this evil. Serious times demand a serious response.
Brown Wood Family Rosary
St Patrick Rosary
By Nikky Andres (CALIFORNIA NETWORK)
On Wednesday, Iran's Supreme Leader Ayatollah Ali Khamenei prohibited further negotiations between Iran and the United States, further isolating Iran following July's nuclear deal. LOS ANGELES, CA (Catholic Online) - Khamenei, who is the highest authority in the ... continue reading
By Talia Ramos (CALIFORNIA NETWORK)
A disturbing video depicting the stabbing of Jewish men was uploaded to YouTube on Hamas' official Channel. YouTube removed the video, calling it a violation of the prohibition against promoting hate speeches. However, the video was reuploaded to a pro-Israel blog. LOS ... continue reading
By Linky C. (CALIFORNIA NETWORK)
American officials revealed that Russian fighter jets intercepted and shadowed U.S. predator drones on three separate occasions following the initiation of Russian airstrikes last week. LOS ANGELES, CA (Catholic Online) - Intelligence reports from U.S. officials ... continue reading
By Linky C. (CALIFORNIA NETWORK)
Rokstan M. managed to escape in Syria after being gang-raped by three men. She fled to Germany but was later murdered by her own father and two brothers, allegedly by her own mother's orders because she was seen as "unclean" after the sexual assault. LOS ANGELES, CA ... continue reading
By Atarah Haely (CALIFORNIA NETWORK)
Russia reportedly dropped at least ten thousand leaflets with distinct messages aimed at civilians and rebel troops, including ISIS members.Through a Kremlin-friendly website, the leaflet details were posted, including warnings for people to leave the area before more ... continue reading
By Talia Ramos (NEWS CONSORTIUM)
Feared Spetsnaz special forces were reportedly sent by Russian President Vladimir Putin to obliterate Islamic State terrorists and the moderate rebel groups against Bashar al-Assad. The special troops' intervention was said to be indicative of Russia's support for the ... continue reading
By Catholic Online (CALIFORNIA NETWORK)
It took awhile for others to catch on, but propaganda videos released by Islamic State, or ISIS, shows them using an extraordinary amount of vehicles from Japanese car manufacturer Toyota. The U.S. Treasury Department has since launched an inquiry as to why. ... continue reading
By Linky C. (NEWS CONSORTIUM)
A Yazidi grandfather shared the tragic story of his three granddaughters who died in the Mediterranean Sea during their attempt to flee the ISIS regime. The children aged 8, 12 and 15 drowned when the smuggler's boat overturned. LOS ANGELES, CA (Catholic Online) - ... continue reading
By Linky C. (NEWS CONSORTIUM)
ISIS recently conquered another Syrian town, which was featured in the latest ISIS propaganda video. ISIS threatened Christians in the area to sign a contract of subservience to Muslim rule or face death. The video also included a warning to Christians in America. LOS ... continue reading
By Kenya Sinclair (NEWS CONSORTIUM)
ISIS members forced pregnant sex slaves to have barbaric abortions that leave the women bleeding heavily and in so much pain they are unable to speak or walk. LOS ANGELES, CA (Catholic Online) - Young Yazidi women who escaped their lives as ISIS sex slaves opened up to ... continue reading


text:
insert into PendingEmails (Subject,Body,ToEmail,PendingEmailStatusID)
select REPLACE( select subject from dbo.EmailTemplates where ID = 7 ), '[CallID]'), (select Body from dbo.EmailTemplates where ID = 7) ,contact.Email ,5
FROM inserted AS i inner join Calls on i.CallID = Calls.CallId inner join Contact on calls.ContactID = Contact.ContactID
where contact.Email is not null and contact.Email <> ''
I want to replace '[CallID]' in the subject with a value. that syntax is not working. I also tried using a variable, wont work either.
What is the best way to do that?


text:
This property allows you to book online with a credit card. After submitting a reservation request, the owner or manager has 24 hours to accept, at which time your card will be charged and you will receive an email confirmation
Recent Other Old Town, South Properties reviews
"Spent the second week of March in Park City skiing. Once again blue skies, warm, minimal crowds and great conditions at the top . This condo made it a perfect week. Location was right up against the mountain for easy access to Quiting Time run and the Town lift. You are just steps from Main Street. Car not needed. It was clean, cozy, comfortable, modern appliances, well stocked. Could not ask for more ! Communication with owner was great. Thank You for sharing ! We will be back."Guest: Becky Date of Stay: March 2015 Review Submitted: March 23, 2015View listing
"I booked the house for a reunion ski weekend with 14 friends. The owner was very helpful and responsive. There was some was some confusion with the house, and the owner did a fantastic job contacting me and resolving all of my concerns. The house was perfectly prepped for our arrival. The place was very clean hand had plenty of fresh linens and towels. The location suited us very well as it was close to town. We walked into town every night for dinner and drinks. The trolley was super close (picks up two doors down). Unrelated to the house, but as an FYI the trolley doesn't start running until 10am, which is unfortunate since the lifts open at 9am. The owner mentioned that she and several other homeowners have been lobbying the town (unfortunately without much luck). The house is good for groups – there's an open floor plan in the main house with the kitchen, living, and dining areas all connected. The hot tub holds 8 fairly comfortably, and is located on the ground-level floor. You can access it through the bedroom/first floor suite with the murphy bed. The driveway has parking for three cars. The VRBO post is a little unclear in the following two areas: 1. The house is actually two separate units in the same building. You cannot get from one unit to the other without walking around the outside of the house. That being said, you just walk ¼ of the way around the house to the other door. This layout helps provide a little bit of privacy with a larger group. 2. The bedroom listed with two twin beds is not a bedroom, but an open air loft. I imagine this would be great for kids, but it doesn't necessarily provide the privacy some adults may desire. Things unrelated to the house but worth knowing if you're coming to the area: 1. Ski rentals: We used Black Tie ski rentals, which was awesome. They deliver and pick up the skis for you and provide a great number of upgrades. 2. Picking up lift tickets: The town lift ticketing window can get a little crowded in the morning. Try to pick up your lift tickets before, or go to the main lodge the first day. 3. Everyone in the group preferred the skiing at Canyons to Park City (both are covered in the Epic pass). 4. The third day we skied Deer Valley, which was nice but ~40% more expensive than Canyons and Park City. Deer Valley is ski only, and had great lift access with minimal cat walks."Guest: Drew Date of Stay: January 2015 Review Submitted: January 28, 2015View listing
"We love this spot in Park City! The best ski in/ski out we have ever had. Kyle and his wife are excellent hosts and go out of their way to accommodate your wishes. Thank you for another great stay at your lovely spot!"Guest: Jill M. Date of Stay: January 2015 Review Submitted: February 8, 2015View listing
"The house is really well located near Main Street. It offers a quick walk to many restaurants, bars, and shops. There is also easy access to nice nature walks and hikes. The house itself is beautiful and contains all of the amenities needed. I will use this rental again."Guest: Danielle E. Date of Stay: August 2015 Review Submitted: August 17, 2015View listing
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