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Malcolm Reed and his love-life *** minor spoiler ***
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June 22 2014, 12:48 PM
Fleet Captain
Re: Malcolm Reed and his love-life *** minor spoiler ***
I think as long as the relationship received fair screen time, and the relationship were handled well - a normal amount of affection - people who want gay characters would be happy. I don't recall anyone ever asking for a gay story - just gay characters.
Although I liked Ezri Dax I thought it was disappointing that the next Dax wasn't a man. Worf's reaction alone would've made it worth it! But that would've left DS9 with only one female lead, which would've been a problem.
I would think that once an Andorian was past their fertile age, that it wouldn't be such a big deal if they were then in an untraditional relationship. It's worth pointing out that on Andor, exclusive heterosexuality would be just as scandalous I would expect as homosexuality. Anything outside of being attracted to the other three genders would be a cultural taboo. I am really fascinated by the Andorians.
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Thursday 08 October 2015
BGF provides long-term capital for fast growing British companies. Since its launch in May 2011 it has made nearly 60 investments, providing more than £300m of new capital to UK enterprises. Read this guide to find out more about growth capital and discover how an equity investment with BGF could help your business to reach its full potential

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Gus van Sant
Tom Hiddleston Reveals Why He Was Cut From Avengers: Age Of Ultron
'Avengers: Age of Ultron' would've been just as successful with or without the inclusion of the hugely likeable Tom Hiddleston (we think), but now the actor's revealed why he was cut from the movie. Speaking to Digital Spy, the charming Brit who plays the devilish Loki in the Marvel Cinematic…Mike P Williams
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Batman v Superman: Jesse Eisenberg Actually Playing Lex Luthor Jr
Jesse Eisenberg won't be portraying the Lex Luthor we all know and love in next year's 'Batman v Superman: Dawn of Justice'. In fact, Eisenberg will playing Alexander Joseph Luthor Jr, son of Lex Luthor Snr, who has taken over his father's company and turned it into a tech giant. The unexpected…Ben Skipper
Twitter Launches Moments, the Curated News Experience Also Known as Project Lightning
Twitter made a big push towards simplification Tuesday with the launch of Moments, a new curated news experience that is initially only available to U.S. web and mobile users. Moments was previously known as Project Lightning, and has been touted by company executives as a major step to get new…Variety
What Movie Should I See This Weekend?
Preview all of this weekend's new theatrical releases (including The Walk, Pan, Steve Jobs, and Victoria), with Metascores and trailers for each new film. Read and Post Comments | Get the full article at MetacriticMetacritic
John Woo to Produce TV Series 'Cognition' with Catalyst
CANNES — John Woo, whose credits include "Mission Impossible II" and "Face/Off," is to produce a original scripted television series titled "Cognition" in partnership with Catalyst Global Media, the television and film production company led by Charlotte Walls and Al Hardiman. The show is a…Variety
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'Twilight' Character Gender Flip!
Prepare to have your "Twilight" mind blown – Edward Cullen is now a girl!? In the new work, Bella Swan (played by Kristen Stewart on the big screen) is now a guy named Beau (short for Beaufort). Edward Cullen (played by Robert Pattinson in the movie franchise) is now Edythe.Access Hollywood
F. Gary Gray Likely to Direct 'Fast & Furious 8'
"Fast and Furious 8" may have found its director. "Straight Outta Compton" helmer F. Gary Gray looks to be the choice to direct the latest installment in the franchise, sources tell Variety. "Furious" star and producer Vin Diesel posted a photo of himself with Gray on his official Facebook page,…Variety
Parody trailer for Jaws 19
Universal Studios has released a parody trailer for Jaws 19 as part of the lead-up to the release of the Back to the Future 30th Anniversary Trilogy on Blu-ray and DVDZoomin TV
EFA to Honor Christoph Waltz, Charlotte Rampling
The two stars will be picking up honorary awards at the Dec. 12 event in Berlin.The Hollywood Reporter
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Endemol Shine CEO Defends TV Business: "We Have Never Had It So Good" – Mipcom
In her first major speech since taking over the post of CEO of Endemol Shine Group, Sophie Turner Laing today sounded a defense of the TV business, and offered up considerations for the future of the fast-evolving landscape. In a talk that might have been just as suited for the UK's prestigious…Deadline
'Kilo Two Bravo' Director & Writer Ink With Verve
EXCLUSIVE: Kilo Two Bravo director Paul Katis and writer Tom Williams have signed with Verve, the lit agency said today. The war drama, BAFTA nominated this past year when it was known as Kajaki: The True Story , recounts the story of a platoon set out to disable a Taliban roadblock. On nearing…Deadline
Jeanne Tripplehorn, Callum Keith Rennie Join Cast of 'Little Pink House'
Production on the film is about to begin in Vancouver.The Hollywood Reporter
GoPro Steals the Show in Fox's "The Martian"
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Tom Hanks and Steven Spielberg Describe Their Cold War Drama 'Bridge of Spies'
Hanks plays James Donovan, an American lawyer tapped to defend a Soviet spy charged with espionage.ABC News Videos
PFW Photo Diary: Roger Vivier Gets Groovy
The grand Maison de l'Amerique Latine in Paris set the stage for Roger Vivier's Summer Sweets presentation.The Hollywood Reporter
'Assassin's Creed': A Video Game Movie That's Worth Watching?
'Assassin's Creed' is already shaping up to be the best video game adaptation we've ever had. With a bar this low, how could it not be?The Cheat Sheet
MTV's Nicole Byer Pilot Casts Sophie Von Haselberg, Fahim Anwar & Rachel Hilson
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Fox Developing Couples Dancing Show As 'So You Think You Can Dance' Awaits Renewal Decision
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Kirsten Dunst Thinks TV Is Way Better Than Film
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Hasbro to roll out 4 more 'Transformers' films
The president of Hasbro Studios revealed that the company will release four more "Transfomers" films in the next 10 years.CNBC


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- Football Sterling Heights Stevenson 35 Utica Ford 7 10/02
- Football Romeo 26 Macomb Dakota 14 10/02
- Boys soccer Macomb Dakota 1 L'Anse Creuse North 1 9/30
- Boys soccer Utica Eisenhower 2 Utica 0 9/30
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- Boys tennis Brother Rice 6 Grosse Pointe South 2 9/28
Grosse Pointes
University Liggett falls to St. Ignace in MHSAA state semifinal
By Thomas Franz
March 13, 2014
Emily Hinsman and Abbey Ostman combined for 25 of St. Ignace's 34 points as the Saints defeated University Liggett 34-30 in a MHSAA Class C state semifinal at the Breslin Center on Thursday afternoon.
St. Ignace took a 28-19 lead into the fourth quarter, but Liggett's Nia Ahart tied the game at 30 by hitting a floater with 2:30 left in the game.
St. Igance answered with a Hinsman bucket, then Margo Brown scored her only two points of the game at the free-throw line to put the Knights away.
St. Ignace shot 18.8 percent from the field, but the Saints out-rebounded Liggett 59-36.
"We are better than what we showed tonight, but you have to give a lot of credit Liggett for that. I don't want to say we just shot poorly, obviously we did, but they had a lot to do with that," St. Ignace coach Dorene Ingalls said.
Lola Ristovski led Liggett in scoring with nine points and Ahart added eight. Jessica Rotzoll added five points and grabbed 12 rebounds.
St. Ignace advances to play Saginaw Nouvel in the Class C state championship on Saturday at 4 p.m. Liggett closes its season with a 20-4 record.
September 28, 2015
Farmington Hills Harrison
Farmington Hills Harrison earned the honor after beating Southfield High 17-14 at home in a battle for first place in the Oakland Activities Association White Division. The win put the Hawks 4-0 (4-1 overall) in the division, a game ahead of Southfield. After trailing 14-7 at the half, Harrison scored 10 unanswered points, capped off by a 27-yard field goal by Alex Bolstrum with 10:57 left in the game. In the last four meetings between these rivals, each team has won twice with a 4.5 average margin of victory.


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Shop Charlie Rocket by Category
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If you're a mom looking for an extraordinary clothing brand for boys, I'm sure you know how difficult it can be, but now there's an amazing option you'll love! Meet Charlie Rocket. A well-made, award-winning boys clothing brand that creates fun, functional clothes made in Los Angeles, California.
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Book your room at Best Western Hotel Am Vitalpark
Premium Room, 1 Double Bed, Balcony (Cozy)Max Occupancy: 4 guests (up to 3 children)
Suite, 1 Double BedMax Occupancy: 4 guests (up to 3 children)
Comfort Room, 1 Double Bed, BalconyMax Occupancy: 3 guests (up to 2 children)
Get an overview of this hotel4.5-star hotel with 2 restaurants and 4 indoor pools
Hotel Features
This smoke-free hotel features 2 restaurants, 4 indoor pools, and an outdoor pool. Free buffet breakfast, free WiFi in public areas, and free self parking are also provided. Additionally, a health club, a bar/lounge, and a coffee shop/café are onsite.Information missing or incorrect? Tell us!
Hotel Amenities
Hotel Amenities
Best Western Hotel Am Vitalpark features 4 indoor swimming pools and 2 spa tubs along with an outdoor pool, a health club, and a steam room. Dining is available at one of the hotel's 2 restaurants and guests can grab coffee at the coffee shop/café. A bar/lounge is on site where guests can unwind with a drink. A complimentary breakfast is offered each morning. Public areas are equipped with complimentary high-speed wireless Internet access.
This Heilbad Heiligenstadt hotel also offers multilingual staff, a hair salon, and a safe deposit box at the front desk. Complimentary self parking is available on site.
Best Western Hotel Am Vitalpark is a smoke-free property.
- 24-hour front desk
- Babysitting or childcare
- Bar/lounge
- Coffee shop or café
- Conference space
- Elevator/lift
- Free breakfast
- Free self parking
- Free WiFi
- Hair salon
- Health club
- Multilingual staff
- Number of floors - 5
- Number of indoor pools - 4
- Number of restaurants - 2
- Number of spa tubs - 2
- Outdoor pool
- Safe-deposit box at front desk
- Smoke-free property
- Steam room
- Total number of rooms - 130
Family Friendly Amenities
- Babysitting or childcare
- Free Wi-Fi
- Indoor pools
- Outdoor pool
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Free self parking
Room Amenities
- Air conditioning
- Balcony or patio
- Blackout drapes/curtains
- Coffee/tea maker
- Cribs/infant beds available
- Desk
- Flat-panel TV
- Free WiFi
- Hair dryer
- In-room safe
- Iron/ironing board
- Minibar
- Pillow menu
- Private bathroom
- Room service
Where to Eat
Guests are offered a complimentary buffet breakfast each morning.
Theodor Storm - This fine-dining restaurant specializes in international cuisine and serves dinner only. Reservations are required. Open daily.
Leineaue - This restaurant specializes in local cuisine and serves lunch and dinner. Open daily.
Room service is available.
Nearby Things to Do
4 indoor swimming pools and 2 spa tubs are on site along with an outdoor pool. Other recreational amenities include a health club and a steam room.
The recreational activities listed below are available either on site or nearby; fees may apply.
- Fishing on site
- Golf driving range on site
- Miniature golf on site
- Golfing on site
- Horse riding/rental on site
- Accessible path of travel
- In-room accessibility
Hotel Policies
Check-in time starts at 3 PM
Check-out time is 11 AM
Payment types
Pets allowed
Optional extras
- Pet fee: EUR 30 per pet, per stay
National Rating
Hotelstars Union assigns an official star rating for properties in Germany. This property is rated 4 star Superior and is displayed on this page as 4.5 stars.


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The new Yardbarker app is here! Install on your iPhone, iPad or Android device. You can also find us in Google Newsstand.
Former NFL Player Calls the NFL a Cult
You read that headline right. Former NFL linebacker Terry Crews, who played a total of 32 games in three seasons back in the 1990′s, has some strong words against the National Football League and its prescription drug-related issue that is now being brought to the front burner due to a lawsuit that was filed in San Francisco against the league this week. Crews, who is now an...
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Ex-players say teams gave pain pills 'like candy'
Former NFL lineman Jeremy Newberry often hobbled into the 49ers locker room on game days using a walking boot and crutches, then lined up behind as many as two dozen teammates, in his case to get a shot of the painkiller Toradol in the butt. Ten minutes later, he sprinted out of the tunnel and onto the field. The toughness of pro football players may be legendary, but a lawsuit filed...
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May 21, 2014 | Discuss
Ex-NFL players say teams gave pain pills out 'like candy'
The NFL is about to face a whirlwind of backlash thanks to a lawsuit filed Tuesday on behalf of more than 600 former players. The suit alleges that team physicians and trainers across the league routinely handed out powerful drugs and other controlled substances on game days to help players mask their pain. Though it's not shocking that the use of painkillers is rampant across...
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Welcome to Horizons Software Official website
Enterprise-Wide Strategy and Performance Management System
Multi-Levels, Multiple-Views Web-Based Enterprise Strategy Management
Real-Time and Live Connections to Measurement Information Sources
Dynamic Alignment of Strategy Objectives and Measures across Enterprise Units
Multiple Stakeholders Reporting and Data Entry
Programs, and Projects Portfolio Tracking and Management
Full Support for Project Management International Standards and Processes
Real-Time Integration with EPM Scheduling Systems
Welcome to Horizons Software Official website
Address: 93 Haroun Al Rasheed Street, Heliopolis, Cairo, Egypt 11351
Tel: +202-2644-3709
Mobile: +20100-167-0914
Fax: +202-2632-0661
email: email@example.com
Horizons has released its Tasks Management System (Enjiz) the first bilingual and proactive social task tracking solution to collaborate track and complete tasks. Enjiz empowers users to monitor their tasks in an easy and visual manner from the web, outlook or mobile clients
A new addition to Horizons Products. An easy to use Indicators Publishing Solution for Web, Tablet, and Mobile users.
Newly released PMOS 3.3 is now shipping with new features
- View tasks relations in Gantt chart
- Integrated authentication with active directory
- New module for evaluation
- Training management module (define, plan, and manage)
- Issue historical program completion percentage report
- Tasks management enhancements:
Assign tasks to multiple persons
When a task is late, automatically delay its successors
Add relation between tasks and cost items
Don't allow finish of task unless its predecessors are finished
Now Strategy Architect 5.3 is shipping with a new architecture, new user interface, and rich set of graphics. New features:
Enables user to connect an indicator to a data source for automatic data synchronization. The synchronization is based on a schedule configured by the administrator.
We support SQL, Oracle, Excel, Postgre SQL
A visual dashboard for indicators, where user can compare the progress of all indicators in a BSC, grouped by objective.
A view which shows all indicator information for needed analysis.
History Data
Indicator causes hierarchy and their Data
Indicator cascaded hierarchy and their Data
Assessments as well as ability to add assessment.
An easy way to navigate in Balanced scorecards through:
Cascading hierarchy
List BSCs that you have permission for
Recently accessed BSCs through last sessions.
A view that shows BSC Indicators' history. Where the user can configure
Time range shown through a visual and easy to use time slider.
Values shown in the view to be one from the following
Period To Date (PTD) Value
PTD Index
Year To Date (YTD) Value
YTD Index
This data is also available in report format. Where the user may generate it for multiple BSCs.
A generated report is available to be saved in word. Excel and PDF formats.
An easy to use search that enables the user to easily find the required object in the system.
Horizons team completed successfully the re-certification of its CMMI Maturity Level 3 on August, 2013


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Vixen - Ascot 8x32 CFW Binoculars
With 15mm of eye relief, a wide field of view, and a 32mm objective lens size, the Vixen Ascot 8x32 binoculars are great for sporting events.... Learn MoreModel#: 1560
Vixen - Illuminated Guiding Adapter GA-4
An essential tool for manual guiding, the GA-4 adapter projects an illuminated reticule of 6 concentric rings onto any 1.25" eyepiece of your choice.... Learn MoreFREE SHIPPINGModel#: 3703(48 States)
Regular Price: $349.00
Special Price: $314.10
Vixen - Porta II Adapter
Supplied with the Porta II Mount. Use to attach the original Porta Mount head on a Skypod Tripod, a table top tripod or an SX half pillar.... Learn MoreModel#: 38012
Vixen - 95mm VMC95L (f/11) Reflector Telescope - (Mini Porta Mount)
Vixen - VMC95L with Mini PortaMount... Learn MoreFREE SHIPPINGModel#: 33923(48 States)
Vixen - EA36.4mm to 42mm
36.4mm Thread; 15mm long light path; Wt 1.4oz... Learn MoreModel#: 37201
Regular Price: $64.95
Special Price: $58.46
Vixen - NLVW 30mm Lanthanum EyepieceVixen - NLVW 30mm. Lanthanum ... Learn More
FREE SHIPPINGModel#: 39301(48 States)
Vixen - Soft Case for Geoma 82mmVixen Soft Case for Geoma 82mm AS-GC-6222 is designed for models Vixen Geoma Pro 82A Spotting Scope, Vixen Geoma Pro 82S Spotting Scope, Vixen Geoma Pro ED 82A Spotting Scope and Vixen Geoma Pro ED 82S Spotting Scope ... Learn More
Model#: AS-GC-6222
Vixen - Ascot 7x50 CF Binoculars
In a dark site during the summer months and the vast Milky Way is shining above you, you'll definitely want to have the Vixen Ascot 7x50 Binoculars handy to scan the wonders of our galaxy.... Learn MoreFREE SHIPPINGModel#: 1562(48 States)
Vixen - AC Plug Adapter Sphinx Mount
This is the adapter that will allow you to use your Vixen #3599 AC power cord and connect to your Sphinx or SkyPod Mount.... Learn MoreModel#: 2537
Vixen - AXD Counterweight 3.3lb (1.5kg)Vixen-AXD Counterweight 3.3lb (1 ... Learn More
FREE SHIPPINGModel#: 36912(48 States)
Vixen - Piggyback fine adjustment unit dxA guiding scope, camera, or spotting scope can be mounted on this unit's 1/4"-20 bolt for precise up-and-down and side-to-side slow motion control. It's a heavier duty unit than the regular fine adjustment unit ... Learn More
Model#: VIXEN-3562
Vixen - Tube Rings 115mm ID Pair
Vixen Tube Rings are designed for use with Vixen's Dovetail Plate (#2661). They will allow you to fit many different Optical Tube Assemblies to your Vixen Mount... Learn MoreModel#: 2665
Regular Price: $139.00
Special Price: $125.10
Vixen - Dovetail Plate Mounting BlockFor installing an optical tube with the standard dovetail attachment ... Learn More
Model#: 3810
Vixen - Polarie Star Tracker with Tripod and 2 Ball Heads... Learn More
FREE SHIPPINGModel#: 35505P1(48 States)
Regular Price: $599.00
Special Price: $499.00
Vixen - 9mm NLV Lanthanum Eyepiece... Learn More
Model#: 37106
Vixen - Digiscoping Balance PlateUsed for balancing a field scope with an attached camera ... Learn More
Model#: 1811
Regular Price: $34.95
Special Price: $31.46
Vixen - Porta II Mount
The Porta II is a solid altazimuth mount with a 20lb payload capacity and features Slow Motion Flexible Handles to minimize vibrations and keep your view sharp.... Learn MoreFREE SHIPPINGModel#: 5863(48 States)
Vixen - 5-15x17 CF Flat Zoom Binoculars
The lever focusing system and slide zooming are smooth and quick in operation. Includes a soft case and carry strap.... Learn MoreModel#: 1640
Vixen - ED100Sf 100mm ED Apochromatic Refractor Telescope Package with GP2 MountED100Sf 100mm ED Apochromatic Refractor ... Learn More
FREE SHIPPINGModel#: 2618GP2(48 States)
Vixen - Dielectric Coated 2" Diagonal
Vixen Dielectric Coated 2" Diagonal Eyepiece Adapter sports a dielectric coating to give you true color images. The Vixen 2" Diagonal Adapter assures you of high contrast sharpimage images. This Vixen eyepiece has a fully illuminated 2" field of view.... Learn MoreModel#: 5449
The Vixen Co., Ltd has manufactured the most respected line of Telescopes and Mounts in Japan since 1949, where it is the #1 selling brand. Vixen produces a varied selection of telescopes, mounts, binoculars and spotting scopes. Each product is fully inspected to meet Vixen's high standard of quality.
Vixen has created unique, high quality optical products and was the first to introduce a Go-To Mount for astronomical telescopes.
With a vast product line, Vixen offers telescopes and mounts for users of all levels. Most Vixen Mounts and Telescopes are interchangeable. As your needs change, the industry standard Universal Dove Tail System makes it easy to change your equipment. In most cases, users can swap out an optical tube for the next size and continue your observing session.
Terrestrial observers find that the quality and workmanship evident in Vixen's Mounts and Telescopes is also evident in the Sport Optics products. The same technology that was developed to product telescopes, is evident throughout the full line Vixen Optical Products.
The Vixen Co., Ltd derives its name from Santa's Reindeer. The Vixen company philosophy is to bring happiness to users of Vixen products. When you compare Vixen products to others, the difference is evident. Vixen attaches great importance to flexible ideas and continues to pursue technical advancements in order to make your experience more enjoyable.


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Chemokine CXCL12 and its receptor CXCR4 expression are associated with perineural invasion of prostate cancer
© Zhang et al. 2008
Received: 22 September 2008
Accepted: 04 November 2008
Published: 04 November 2008
To identify the roles of CXCL12 and CXCR4 and the associated mechanism involved in perineural invasion of prostate cancer.
The distribution and expression of CXCL12, CXCR4, MMP-2 and MMP-9 in human prostate cancer and in tumor cells invading nerve tissue were studied with immunohistochemical staining. The effects of exogenous CXCL12 and CXCR4 antagonist AMD3100 on PC3 prostate cancer cells invasiveness were assessed in vitro and in vivo.
The expression of CXCL12, CXCR4, MMP-2, and MMP-9 in human prostate cancer were higher than those in hyperplastic prostate tissues (P < 0.05). In vitro CXCL12 could stimulate the PC3 cells invasiveness (P < 0.05) while AMD3100 could inhibit invasiveness. In vivo, the number of nerves around the tumor tissue in the group treated with CXCL12 was significantly higher than that found in the control group (P < 0.05). Both the control group and the CXCL12-treated group had more nerves number near the tumor tissue than it found in the AMD3100-treated group. The positive cell number of CXCL12, CXCR4, MMP-2, MMP-9, and NGF expression ranked from highest to lowest, were the CXCL12-treated, the control, and the AMD3100-treated group(P < 0.05).
CXCL12 and its receptor CXCR4 along with MMP-2 and MMP-9 are related with prostate cancer perineural invasion.
perineural invasion
C-X-C chemokine ligand 12
C-X-C chemokine receptor 4
- rpm:
revolutions per minute
phosphate-buffered saline
matrix metalloproteinase
nerve growth factor
vascular endothelial growth factor
Perineural invasion (PNI) of malignant tumor cells means tumor cells tend to encroach upon nerve fibers and invade the lamellar sheath, leading to infiltration and metastasis. This phenomenon is often seen in adenoid cystic carcinoma, pancreatic cancer and prostate cancer [1]. Prostate cancer PNI usually localizes in a few important nerves, influencing the patients' quality of life and making it difficult to remedy. Residual tumor cells in nerve tissue may contribute to local recurrence and metastasis and influence prognosis [2]. Other studies have shown that the mechanism of PNI involves the microenvironment around the nerve tract that is suitable for tumor cell growth and proliferation. This situation promotes tumor cell infiltration and diffusion along nerve fibers [3].
Chemokines are small, secreted peptides that control adhesion and transendothelial migration of leukocytes, lymphocytes, and monocytes, especially during immune and inflammatory reactions. Chemokines combine with G-protein-coupled-receptors to perform their function. Chemokines and their receptors have significant roles in tumor metastasis, recurrence and angiogenesis [4]. Among the family of chemokines and their receptors that significantly contribute to the initiation and development of tumors, CXCL12 and its receptor CXCR4 are the most frequently mentioned. CXCR4 is the unique receptor for CXCL12, also named stromal cell-derived factor 1 (SDF1). Prostate cancer cells secrete many chemokines and their receptors, also found in cells in other tissues of the body, and these chemokines are involved in the prostate cancer cells' organ-specific metastasis [5]. During the process of prostate cancer PNI, MMP-2 and MMP-9 play an important role in degrading the matrix around the tumor and the nerve tissue. Our research aims to study CXCL12, CXCR4, MMP-2 and MMP-9 expression in prostate cancer PNI using in vitro experiments, animal model experiments and human prostate cancer tissue. The study was the first time to report the roles of CXCL12 and CXCR4 in PNI of prostate cancer.
Materials and methods
Cell lines and materials
Human androgen-independent prostate cancer cell line PC3 was provided by the central experiment lab of Tianjin Cancer Hospital.
Transwell experiment
PC3 cells were cultured in RPMI 1640 without serum at 37°C with 5% CO2 and were adjusted to 1 × 105-1 × 106 cells/ml. The liquid extracellular matrix (ECM) gel (Sigma-Aldrich, St. Louis, USA) was pre-cooled to 2–8°C and 16.5μl was added to the upper surface of each Transwell chamber filter (Corning corporation, New York, USA). The chambers were incubated at 37°C with 5% CO2 for one hour to allow the matrix to solidify and then 1 × 104-1 × 105 PC3 cells in suspension were added to the upper chambers. For the controls, 600 μl serum-free medium was added to the lower chamber. For the CXCL12 experimental wells, 600 μl serum-free medium supplemented with 0.1 μg CXCL12 (Jingmei corporation, Tianjin, China, reconstituted with Saline) was added to the lower chamber. For the CXCR4 antagonist experimental wells, 600 μl serum-free media supplemented with 12 pmol AMD3100 (Sigma corporation, USA, reconstituted with Saline) was added to the lower chamber. The chambers were incubated for 20 hours at 37°C with 5% CO2. The upper surface of the filter was removed using a cotton swab. Cells that invaded through the ECM and the filter to the lower surface were fixed using 5% glutaraldehyde and were then stained with H&E. The cell number in five fields (up, down, median, left, right. ×400) were counted for each chamber, and the average was determined. Each experimental condition was repeated four times.
Model of prostate cancer and tumor experiments in BALB/C nude mice
BALB/C nude mice were obtained from the Academy of Military Medical Sciences of China. Six to eight-week-old, 20 to 25 g BALB/C nude mice (14 males and 14 females) were used to establish the perineural invasion model. Each mouse received a groin injection of 1 × 106 PC3 cells. On the 18th day after inoculation, the mice were divided randomly into three groups and received treatment for 10 days. In the CXCL12 group (n = 8) each mouse was treated with CXCL12 at 0.1 μg/day[6]. In the AMD3100 group (n = 10) each mouse was treated with 10 pmol/day AMD3100[7]. In the control group (n = 10) each mouse was treated with 0.1 ml/day sodium chloride. The mice were sacrificed after 10 days of treatment, and the tumor mass and surrounding tissue were removed, fixed with formalin and made into tissue sections.
Counting the number of nerves around the tumor tissue in H&E stained sections
Microscopic analysis was performed on H&E stained sections. The nerves within one field (400×) of the tumor tissue were defined as being near the tumor. The nerves away from the tumor tissue more than one field (400×) were considered far from the tumor. The average number of nerves near and far from the tumor tissue were determined by counting the mean value in five fields (400×).
Immunohistochemical staining and quantification
Polyclonal antibodies used in this study were rabbit anti-MMP-2 (Boster Wuhan, China, dilution 1:100), rabbit anti-MMP-9 (Boster Wuhan, China, dilution 1:100), rabbit anti-CXCL12 (Boster Wuhan, China, dilution 1:150), rabbit anti-CXCR4 (Boster Wuhan, China, dilution 1:100) and rabbit anti-NGF (Boster Wuhan, China, dilution 1:100). Four-micrometer sections of formalin-fixed paraffin-embedded tissue were mounted on poly-L-lysine-coated slides. The slides were air-dried and the tissue was deparaffinized. Endogenous peroxidase activity was blocked with 3% hydrogen peroxide in 50% methanol for 10 min at room temperature. The sections were rehydrated and washed with PBS and then pretreated with citrate buffer (0.01 M citric acid, pH 6.0) for 20 min at 100°C in a microwave oven. After nonspecific binding sites were blocked by incubating in 2% normal goat serum in phosphate-buffered saline (PBS) for 15 min at 37°C, the sections were incubated overnight at 4°C with the primary antibody. The sections were then washed with PBS and incubated with the secondary HRP-conjugated antibody for 30 min at 37°C. Staining was performed by incubating with fresh 3,3'-diaminobenzidine (DAB) buffer. The sections were washed in running water and counterstained with hematoxylin, followed by dehydration and mounting. PBS was utilized in place of the first antibody for the negative control.
When stained for MMP-2, MMP-9, CXCL12, CXCR4 and NGF, tumor cells with brown cytoplasm were considered positive. We observed 10 fields per section at 400× magnification, and positive cell numbers were counted in 100 random melanoma cells in every field. The mean percentage of positive cells was used to determine the expression of the proteins in a section. All these counts were blindly performed in at least 3 randomly chosen sections from each mouse.
Clinical data and pathological material for human prostate cancer cases
The clinical and pathological characteristics of 42 cases of prostate cancer and prostate hyperplasia
clinical and pathological characteristics
Mean age (range)
Prostate cancer
68.40 ± 9.55 (57–85)
prostate hyperplasia
64.18 ± 11.74 (45–81)
Histologic examination
Prostate cancer
prostate hyperplasia
Fibromuscuadenomaoid node, adenomaoid node, leiomyomaoid node and fibrohemangioid
Pathological evaluation
Prostate cancer
Gleason grade IV 10(45.5%) and Gleason grade V 12(54.5%)
prostate hyperplasia
Moderate hyperplasia 12(60%) and severe hyperplasia 8(40%)
Prostate cancer
78.53 ± 29.75
prostate hyperplasia
45.25 ± 18.97
Local invasion and metastasis
Prostate cancer
Local invasion 14(63.4) and metastasis 2(9%)
prostate hyperplasia
Level of prostate specific antigen in blood(ng/ml)
Prostate cancer
68.57 ± 50.43
prostate hyperplasia
20.21 ± 3.27
Statistical analysis
Statistical software SPSS 10.0 (Chicago, Illinois) was used to perform the analysis. Differences among groups were assessed using the ANOVA test, and the least significant difference (LSD) test was used to compare the differences between every combination of two groups. Differences between two groups were assessed using a t test. A P value less than 0.05 was considered statistically significant.
The invasiveness of human prostate cancer PC3 cells
The average number of invading cells in the three groups
CXCL12-treated group (n = 4)
Untreated control group (n = 4)
AMD3100-treated group (n = 4)
Average number of invading cells
169.7 ± 47.23#
115.45 ± 26.49
77.30 ± 33.30
F value
Tumor growth in inoculated animals
Pathological examination
The tumors appeared to be nodular, and most of them had complete pseudo-encapsulation. The tumor cross section was light pink or pale. Histologically, PC3 cells had moderate eosinophilic cytoplasm, round nuclei and prominent nucleoli. Many nerves grew around the tumor lesion. Some tumor cells surrounded nerves and some tumor cells invaded into the lamellar sheath (Figure 2B).
The average number of nerves near and far from the tumor tissue in the three groups
CXCL12-treated group (n = 8)
Untreated control group (n = 10)
AMD3100-treated group (n = 10)
Number of nerves near tumor
8.73 ± 4.42*#
5.11 ± 2.39*
2.80 ± 1.19#
Number of nerves far from tumor
1.91 ± 1.10
2.22 ± 1.64
1.24 ± 0.66
F value
The detection of CXCL12, CXCR4, MMP-2, MMP-9, and NGF expression by immunohistochemical staining
The average positive cell number of CXCL12, CXCR4, MMP-2, MMP-9, and NGF expression in the three groups ( ± s)
11.64 ± 4.96
19.81 ± 0.91
13.94 ± 4.63
12.96 ± 3.20
24.25 ± 5.41
Untreated control
18.30 ± 6.53
26.09 ± 5.48
22.47 ± 3.30
18.72 ± 3.26
31.72 ± 3.38
34.63 ± 5.04
53.83 ± 5.75
41.03 ± 8.21
32.97 ± 6.97
51.24 ± 13.87
F value
The expression of CXCL12, CXCR4, MMP-2 and MMP-9 in human prostate tissue
The average positive cell number of CXCL12, CXCR4, MMP-2, and MMP-9 expression in prostate cancer and prostate hyperplasia ( ± s)
Prostate cancer
37.30 ± 13.24*
37.09 ± 14.66*
42.86 ± 15.44*
52.48 ± 23.51*
Prostate hyperplasia
2.87 ± 1.17
3.27 ± 0.71
11.23 ± 5.10
19.22 ± 4.75
t value
Prostate cancer is the most commonly diagnosed malignancy and the second leading cause of cancer-related deaths in the Western male population[8]. Its incidence in China has greatly increased from 1.71 per 100,000 men in 1993 to 7.9 per 100,000 men in 2005. PNI is one of the most important characteristic of prostate cancer, as well as the cause of frequent recurrence and poor prognosis. PNI usually occurs in critical local nerves, and influences patients' quality of life and causes the disease difficult to cure[9]. Recurrence and metastasis are common when the disease is diagnosed in the later stages and mean a poor prognosis. Residual tumor tissue in nerve tissue is to blame for extracapsular spread and recurrence, which often results in treatment failure. Reports suggest that 79% of prostate cancer samples obtained during surgery display PNI [10] and that PNI is associated with tumor pathological grade, clinical stage and Gleason score. Elucidation of the trigger and mechanism involved in prostate cancer PNI is critical for improving prognosis and promoting clinicians choose the most appropriate therapy.
Besides their well-established roles in the inflammatory reaction, chemokines participate in many physiological and pathological behaviors including lymphocyte homing, immunity, infection, autoimmune disease, angiogenesis and so on [11]. Of late, increasing evidences suggested that chemokines were closely related to tumor growth, invasion and metastasis[12]. Among the family of chemokines and their receptors that significantly contribute to the initiation, progression, invasion and metastasis of tumors, tumor cells expressing high CXCR4 are often found in tissue expressing CXCL12, perhaps due to organ-specific metastasis[13]. One possible mechanism involves chemokines combining with their receptors to induce membrane wrinkling in tumor cells that forms pseudopodia. The tumor cells then adhere to and traverse through the extracellular matrix and basal membrane to enter the blood circulation and metastasize. However, there are not reports about chemokines and their recepters involving with PNI. Furthermore, The previous views suggested that tumor cells express high CXCR4 and the metastasis-targeted organs express high CXCL12, so the tumor cells were attracted to the ligand in these organs[14]. In our study, tumor cells not only expressed CXCR4, but also CXCL12. CXCR4 and CXCL12 jointly promote prostate cancer PNI. This phenomenon indicates that there may be autocrine stimulation by CXCL12 in tumor tissue. Some research validated that tumor cells can also express CXCL12. Taichman[15] showed that PC3 and DU145 prostate cancer cell lines and hormone-resistant LnCaP and C4-2B prostate cancer cell lines can express CXCL12. Prostate cancer cells with significant CXCR4 expression may escape from primary tumor foci, enter into the lymphatic and blood vessels and migrate toward cells expressing CXCL12. CXCL12 in normal tissue attracts the CXCR4 on the cancer cells, stimulating cell proliferation and inducing angiogenesis [16–18].
The previous explanation for tumor PNI is that interstitial tension around nerves is generally weak, making the microenvironment surrounding the lamellar sheath suitable for tumor cell growth. However, this explanation cannot adequately detail the molecular mechanism involved in prostate cancer PNI. Our study concludes with the idea that chemokines and their receptors interacting with MMPs contributed to prostate cancer PNI. CXCL12 can induce tumor cell secretion of MMP-9 that then degrades the blood vessel basal membrane, remodels vessels and stimulates growth of new vessels. All of these features together make it possible for tumor cells to easily enter the circulation. At the same time, MMPs can similarly induce CXCR4 expression in tumor cells.
Perissinotto[19] reported that CXCL12 can markedly upregulate the expression and activity of MMP-9 in osteosarcoma. In the progression of prostate cancer PNI, CXCL12 and CXCR4 secreted by tumor cells and nerve tissue induce tumor cells to migrate toward nerves. At the same time, tumor cells secrete MMP-2 and MMP-9 that degrade the matrix around the tumor and the nerve tissue, promoting PNI. Our research demonstrated that the expression of CXCL12, CXCR4, MMP-2, and MMP-9 in prostate cancer was much higher than in hyperplastic prostate tissue, implying that these proteins interact with each other and together may regulate chemotactic ability and invasiveness of tumor cells.
Exogenous CXCL12 can enhance PC3 cells' ability to penetrate ECM gel. Initially in this process, chemokines combining with their receptors cause actin to concentrate and enhance cell mobility. Muller [20] reported that CXCL12 could increase the concentration of F-actin in breast cancer cells in vivo, thus facilitate the breast cancer cells' migration and invasion in a specific direction. Secondly, CXCR4 combining with CXC12 can rapidly stimulate transmembrane transporting of Ca2+. Vaday[21] showed the specific antibody against human CXCR4 scFv could significantly inhibit the Ca2+ transport mediated by CXCL12 and CXCR4. Thirdly, CXCL12 promotes tumor cell adhesion to the basement membrane components.
AMD3100 is a small highly specific non-peptide antagonist of CXCR4[6]. It can inhibit the signal transduction of CXCL12 mainly through a route that does not involve the ligand-receptor interaction. AMD3100 is capable of inhibiting infiltration by acute lymphoblastic leukemia and ovarian cancer cells[7]. AMD3100 competitively inhibited the CXCR4 binding with CXCL12 and blocked the downstream pathway. In addition, AMD3100 can promote MMP secretion by blocking the downstream of signal transduction pathway about the CXCL12 and CXCR4 interaction.
Nerve growth factor (NGF) not only promotes nerve tissue growth, development and regeneration, but regulates the growth and metastasis of pancreatic cancer, prostate cancer, lung cancer and retinal glioblastoma cells[22]. Results of Oelmann et al[23]. indicated NGF promotes proliferation in three kinds of lung cancer cell lines, and the effect took on dose-dependent. This effect could be blocked by NGF antibody. Research from Zhu et al. [24] showed that pancreatic cancer cells expressed NGF and lamellar sheath expressed TrkA, a combination of receptor and ligand that attracts tumor cells to nerves, leading to invasion and metastasis along nerves. In addition, NGF stimulated the expression of MMPs in tumor cells. Our results indicated that the expression of NGF in the CXCL12-treated group was much higher than that in the control group and the AMD3100-treated group. Of the three groups, the CXCL12-treated group had the highest average number of nerves around tumor. This study suggested that CXCL12 could increase NGF expression in PC3 cells. NGF could combine with its receptor expressed on the cell surface to activate the corresponding signal transduction pathway, enhancing the cells' invasiveness and mobility toward nerves. NGF secreted by tumor cells could also enhance the synthesis and release of some factors including MMPs that promoted cell invasion and metastasis. Furthermore, NGF diffuses around tumor tissue and stimulates nerve growth along this concentration gradient, enabling tumor cells to invade nerves and metastasize. Meanwhile, the increased number of nerves in tumor mass can secrete numerous factors to promote tumor cell growth.
We want to thank Valerie Dunmire for her expert editorial assistance with this manuscript. This work was partially supported by Tianjin Ministry Education Foundation of China (20050224).
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Katita Miller uses her artwork to support a Children's Home in Kenya
Katita Miller ('16), a Studio Art and Spanish double major from Fort Worth, Texas, used her artistic talents to donate over $6,500 to Amazing Grace Children's Home in Awasi, Kenya. Read the full story here!
Greg Pool, Entrepreneur-in-ResidenceThe Center for Innovation, Creativity, and Entrepreneurship sponsors an Entrepreneur-in-Residence who advises and coaches student entrepreneurs in their endeavors. We are proud to welcome this year's Entrepreneur-in-Residence, Greg Pool, to the ICE Program! Greg will be teaching a workshop entitled "How to Launch an App 101" on October 21 from 6-8pm in Carswell 101.
Homecoming 2015
This year, CICE hosted the "Prize Wheel of Fortune" in Reynolda Hall. Current students and alumni spun the wheel, and everyone went home with a prize! We also welcomed alumni back to Wake Forest with an afternoon reception.
A Hot Dog With A Twist
Congratulations Swizzler for ranking in the top 101 BEST Food Trucks by Daily Meal! Recent entrepreneur grads, Jesse Konig, Ben Johnson and Jack Zimmerman, will be making their return to WFU at the end of September to share their innovative Swizzler hot dogs all on four wheels.
Congratulations Prof. Black!Polly Black, AVP and Executive Director of the Center for Innovation, Creativity and Entrepreneurship and part time Professor of Practice, was awarded the 2014-2015 Undergraduate Adjunct Faculty Teaching Award by the WFU School of Business.
Congratulations Professor Black!
Chat with Founder of Tilt
Alum James Beshara was awarded the ICE Excellence in Entrepreneurship award for 2015 and shared his experiences and insight on entrepreneurship as the Founder of Tilt - one of the most successful funding platforms today.
Recent Posts
Wake Forest Senior Uses Artistic Talent to Support Children's Home in Kenya
October 5, 2015
By Allison Pennington, Communications Intern, Center for Innovation, Creativity, and Entrepreneurship Katita Miller ('16), a Studio Art and Spanish double major from Fort Worth, Texas, traveled to Amazing Grace Children's Home in Awasi, Kenya in 2013 while on a mission with her church, All Saints' Episcopal Church of Fort Worth. After visiting the Children's Home, Miller… Read more »
Winston-Salem Discovery Forum Sparks Innovation in the Triad
October 5, 2015
By Allison Pennington, Communications Intern, Center for Innovation, Creativity, and Entrepreneurship On Tuesday, September 29, 2015, Wake Forest University's Center for Innovation, Creativity, and Entrepreneurship and North Carolina State University's Institute for Emerging Issues co-hosted the Winston-Salem Discovery Forum, an event designed to allow young social entrepreneurs to pitch ideas or present existing ventures that… Read more »
Meet Greg Pool, 2015-2016 Entrepreneur-in-Residence
September 29, 2015
By Allison Pennington, Communications Intern, Center for Innovation, Creativity, and Entrepreneurship As any new entrepreneur will tell you, when you're trying to turn an idea into a business model or working to develop a business plan for your start-up, it's vital to learn from those who have been in your shoes. The Center for Innovation,… Read more »
Summer Entrepreneurial Fellows Put Classroom Skills into Action
September 10, 2015
What is the goal of a summer internship? For most students, gaining hands-on experience is at the top of the list. Summer internships provide students with opportunities to try out different careers and put what they've learned in the classroom into practice in the real world. For twenty Wake Forest undergraduates, this year's Summer Entrepreneurial… Read more »
James Beshara, Co-Founder of TILT, wins Entrepreneurship Award
July 14, 2015
In celebration of the 10th anniversary of the Program for Innovation, Creativity and Entrepreneurship, James Beshara ('08), Co-Founder and CEO of Tilt as well as one of Forbes magazine's 30 Under 30 for 2015, was the keynote speaker at the annual Innovation, Creativity and Entrepreneurship Excellence Celebration on Thursday, April 16th. President Hatch presented Beshara with… Read more »


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All Android applications categories
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by: Hungama Digital Media Entertainment Pvt. Ltd. | 1
Tap the drawn number on your card. If you have a line of drawn numbers (horizontally, vertically or diagonally) you must tap the Bingo bottom to claim your point. You can also wait to call bingo after you have formed 2 lines of circled numbers, then you'll score 2 points, unless your opponent calls bingo, before you. The game ends when a player reaches 3 points.
from 1 reviews


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Steve Jobs
The fact that he doesn't try to redeem these flawed, fascinating figures—or even try to make you like them in the slightest way—feels like an…
The fact that he doesn't try to redeem these flawed, fascinating figures—or even try to make you like them in the slightest way—feels like an…
Every once in a while, a movie comes along that is so punishing to one's mental and physical being that the narrative should be divided…
"The Ballad of Narayama" is a Japanese film of great beauty and elegant artifice, telling a story of startling cruelty. What a space it opens…
Patrice Leconte's "Monsieur Hire" is a tragedy about loneliness and erotomania, told about two solitary people who have nothing else in common. It involves a…
A video interview with Guy Maddin and Evan Johnson.
A review of Steven Spielberg's "Bridge of Spies" from its NYFF premiere last night.
An article about "The BlackWhite Love Play."
Our monthly series digs into the career of Wes Craven and comes out with his 3D 2010 film, "My Soul to Take".
A FFC review of "The Look of Silence."
A review of "A Girl at My Door".
A review of season two of FX's "Fargo."
The latest and greatest on Blu-ray, DVD, and streaming including "Magic Mike XXL," "The Duke of Burgundy," "The Connection," and three Criterion releases.
The idea here was to do for teaching what "MASH" did for the war. Unfortunately, they've done for schools what "General Hospital" did for medicine. "Teachers" has an interesting central idea, about shell-shocked teachers trying to remember their early idealism, but the movie junks it up with so many sitcom compromises that we can never quite believe the serious scenes.
The movie begins with a big-city high school where kids get stabbed, students double as drug dealers and police informers, teachers sleep through their classes, and the system is being sued for graduating students who cannot read or write. The bewildered principal is so totally out of touch with all of these developments that his only response is a pleasant nod. We meet the frontline troops. The movie stars Nick Nolte as a one-time visionary who lately has been having trouble finding his way out of hangovers. Judd Hirsch is the overwhelmed assistant principal. Royal Dano is a teacher named Ditto, who specializes in mimeographed examinations every day, so he won't have to talk to his students (he slumbers in the back of the class). There also are the usual student rebels, including Ralph Macchio ("The Karate Kid," 1984) as a bright, alienated con man who knows everybody's weak spot.
The movie revolves around a couple of questions: Will the school lose the lawsuit? Will Nolte tell the truth in a pretrial deposition, or lie to protect the school system? Will he help a sobbing young girl get an abortion, after she has been seduced by the gym teacher? Will the hard-nosed school superintendent (Lee Grant) have Nolte fired? And, inevitably, will Nolte fall in love with the pretty young lawyer (Jobeth Williams) who used to be one of his best students?
One at a time, these questions might be worthy of answers. But "Teachers" throws them at us so relentlessly that the movie begins to feel like one of those soap operas where yesterday's old questions are answered by today's new questions. The movie has a couple of good scenes between Nolte and Macchio, and a few lines that have the zing of painful truth. But there are also scenes played entirely for cheap laughs. And a promising running gag about Ditto never pays off. I don't want to give away the punch line, but see if you're not puzzled by the way a potentially classic gag doesn't quite work. Here's the sad bottom line: "Teachers" was just interesting enough to convince me a great movie can be made about big-city high schools. This isn't it.
A comparison of Frank Costello in The Departed and Whitey Bulger in Black Mass reveals weaknesses in the latter.
A NYFF report on new films from Chantal Akerman and Michel Gondry.
This message came to me from a reader named Peter Svensland. He and a fr...
Our monthly series digs into the career of Wes Craven and comes out with his 3D 2010 film, "My Soul to Take".


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When is the "-wise" suffix okay?
For instance: "We need to do everything we can prevention-wise." Other similar words: taxwise, money-wise, property-wise, food-wise I realise there has been resistance to indiscriminate usage; the question is really about what constitutes "indiscriminate"? Secondly, why the prejudice against what is a productive and concise suffix, when the alternative phrases are cumbersome and pretentious.


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Thanks for helping us associate the correct Pornstars to this video!
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Watch brunette beauty Faith Leon as she rubs her pussy pressed against her black sheer nylon pantyhose. Watch her lick the crotch of the moist nylon when she took it off at the end
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stop talking
Can't help but think she sounds really sarcastic. Fit though.
I will if you are beside me fvck your pussy
hey ty girl had fun not into feet tho but still loved u
nice pink beautifulness . would love to stick it in!
teefs good
Wanna smell her moist sweaty feet after I put off her fuck shoes. Sniff and cum into the stink of her lovely toes and soles.
Как же хочется целовать эти ножки в таких шикарных колготках... Мммм...
She has my vote...would love to taste,head to sexy toe


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8 bedroom detached house for sale Links Avenue, Gidea ParkImpressive eight bedroom detached home set over three floors with impressive views over Gidea Park Golf Club. Offering six reception rooms, eight bedrooms, six bathrooms, walk-in wardrobes, a gym/dance studio and many other fine features. More details ›
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5 bedroom detached house for sale GIDEA PARKBacking directly onto the Romford Golf course a most impressive five bedroom three bathroom family home which has been completely refurbished and modernised to an extremely high standard by the present vendor situated in a much sought after residential area in Gidea Park. The beautifully presente... More details ›
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4 bedroom detached house for sale Crossways, Romford, Essex, RM2BRIAN THOMAS ARE DELIGHTED TO OFFER FOR SALE THIS STUNNING FOUR BEDROOMED DETACHED FAMILY HOUSE. LOCATED IN THE HEART OF GIDEA PARK AND SITUATED WITHIN A MINUTE WALK OF GIDEA PARK MAINLINE STATION PROVIDING EASY ACCESS TO STRATFORD AND LONDON LIVERPOOL STREET. THIS PROPERTY BOASTS FINE FEATURES. More details ›
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4 bedroom detached house for sale Squirrells Heath Avenue, Gidea ParkSet within a beautiful tree lined road which is located within walking distance to Gidea Park Mainline Station is this well presented four bedroom detached family home. This well established 1911 exhibition house offers a spacious kitchen/diner, modern bathroom and a large south facing rear garde... More details ›
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Jun 24, 2014
Argentina on Monday asked US authorities to freeze a ruling that could push the country into default, as it seeks more time to reach an agreement with holdout creditors
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Oct 21 - 22, 2015 | Grand Hyatt, Playa del Carmen, México
SFLA will convene in Playa del Carmen, Mexico the most important issuers and investors from across...
Mar 10 - 11, 2016 | Panama City, Panama
The Forum will convene key players to examine the trends and opportunities to be found in the...
Will a strong dollar deter investors from LatAm bonds?
No, the yield-hunt goes on
Yes, but only retail investors
Yes, once the Fed raises rates
We want to partner and co-invest with US companies from authorized sectors, when they are ready to operate in Cuba.
José Oro, Thomas J Herzfeld Advisors
All material is subject to strictly enforced copyright terms & conditions and cannot be repurposed or reproduced. © 2015 Latin American Financial Publications Inc.


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MAC Cosmetics Veluxe Pearlfusion Shadow: Brownluxe
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- Free Shipping and No Sales Tax (On Orders Over $99)
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Momeni New Wave Purple NW119 Area Rug
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|Material: Wool (100% Wool Pile)
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Reviews for Momeni New Wave Purple NW119 (Total of 0 reviews)(Write Reviews)
|The Momeni New Wave Purple NW119 by Momeni is sometimes listed with the following brand codes: NEWWANW119PUR2030, NEWWANW119PUR3656, NEWWANW119PUR2680, NEWWANW119PUR26C0, NEWWANW119PUR590R, NEWWANW119PUR5380, NEWWANW119PUR790R, NEWWANW119PUR7696, NEWWANW119PUR80B0, NEWWANW119PUR96D6. Also, the following UPC codes: 039425172641, 039425172900, 039425172702, 039425172771, 039425173037, 039425172962, 039425173174, 039425173105, 039425173235, 039425173303
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The Bio Report
The Bio Report podcast, hosted by veteran journalist Daniel Levine, focuses on the intersection of biotechnology with business, science, and policy.
The Stem Cell Podcast
The Stem Cell Podcast is hosted by Christopher Fasano PhD and Yosif Ganat PhD and is dedicated to the field of stem cells. Possible cures, therapies and breakthroughs will be discussed including featured interviews with pioneering stem cell scientists.
CHI Podcasts
The CHI Podcasts are produced by the Cambridge Healthtech Institute and offer in-depth interviews with research and business leaders from many facets of biotechnology.
MicrobeWorld Video - Audio Only
A video podcast by the American Society for Microbiology that highlights the latest in microbiology, life science and biotechnology news. ASM is composed of over 42,000 scientists and health professionals with the mission to advance the microbial sciences as a vehicle for understanding life processes and to apply and communicate this knowledge for the improvement of health and environmental and economic well-being worldwide. For information about ASM and MicrobeWorld, visit us online at www.microbeworld.org. For questions and/or feedback please email firstname.lastname@example.com.
Nature Biotechnology Podcast
Nature Biotechnology podcast is a series of conversations with founders, financers and developers from biotech's past, present and future.
Mad Science: The Genetic Crossroad
FALL 2015 SCHEDULE TO BE RELEASED SOON, STAY TUNED! Anna Kavanaugh hosts the weekly radio series, "Mad Science: The Genetic Crossroad." The program aims to raise awareness and provide education about genetically modified organisms (GMO), in the world food supply and the practices of the GM biotech industry. The series is dedicated to all issues surrounding GM foods, its usage and ramifications thereof. Anna is a writer, advocate, and founder of the (AKCF) Anna Kavanaugh Charitable Foundation. Her original novel, "The Cord of Callows," now an upcoming expanded trilogy series, is the inspiration for a GMO documentary film entitled, "The Cord of Callows trilogy: Fact Behind the Fiction. Fear Behind the Fact."
Pharmaceuticals & Biotechnology | Pharma & Biotech Resources
Listen to a Pharma Show podcast, which focuses on providing professionals in the pharmaceutical industry with up-to-the-minute information and insights from the experts.


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Stone Mountain Park
Stone Mountain, GA 30083
770-498-5690 | 800-401-2407
Stone Mountain Park is Georgia's most visited attraction. With more than 3,200 acres, the park is a unique destination where guests can experience an exciting variety of attractions, entertainment and recreation. Check out Sky Hike, the nation's largest family adventure course in the treetops, or a 4D movie. The Lasershow Spectacular at Stone Mountain Park is the world's longest running lasershow. Other attractions include Summit Skyride, Ride the Ducks, Antebellum Plantation and Farmyard, The Great Barn, Camp Highland Outpost, Scenic Railroad, Great Locomotive Chase Adventure, Geyser Towers, golf and museums.
The largest high relief sculpture in the world, the Confederate Memorial Carving on the mountain, depicts three Confederate heroes of the Civil War: President Jefferson Davis and Generals Robert E. Lee and Thomas J. "Stonewall" Jackson. At Memorial Hall, visitors can see the carving's original designs, scale models and an 11-minute feature film.
Park Gates are open daily, 5:00 a.m. to Midnight. Attraction hours vary. Visit the Calendar page for attraction hours on the day of your visit.
Info & Amenities
Hours of Operation
Sunday: 5:00AM - 12:00AM
Monday: 5:00AM - 12:00AM
Tuesday: 5:00AM - 12:00AM
Wednesday: 5:00AM - 12:00AM
Thursday: 5:00AM - 12:00AM
Friday: 5:00AM - 12:00AM
Saturday: 5:00AM - 12:00AM
Admission & Fees
Mountain Membership (Adult) $59.00
Mountain Membership (Child) $49.00
Mountain Membership PLUS (Adult) $109.00
Mountain Membership PLUS (child) $109.00
Tickets & Special Offers Call or see Website
Nature Trails
Course Type
Facility Amenities
Bus / Motorcoach Parking on Site, Gift Shop, Lodging On Site, Maps & Brochures Available, Meeting Facilities, Parking on Site, Party Facilities, Picnic Area, Public Restrooms, Restaurant on Site, Self-guided Tours
General Information
Family-friendly, Open Year 'Round
Group Amenities
Group Rates Available, Group-friendly
Special Tags
Civil War Site
Suitable for Ages
All Ages
Pumpkin Festival
09/25/2015 - 10/24/2015
Families are invited to take in all of the splendor that autumn provides with fun-filled games and shows at Stone Mountain Park's Twelfth Annual Pumpkin Festival, to take place each weekend during October. Families can twist and turn in Spookley's A-MAZE-ING Adventure maze. Puzzles, passages, twists and turns wi...read more
43rd Annual Stone Mountain Highland Games
10/17/2015 - 10/18/2015
Regale in the spirit of Scotland at the 43rd Annual Stone Mountain Highland Games. Outdoor festivities include Highland athletic events, dancing, piping, drumming and Scottish Harping. Join in for Scottish country dancing demonstrations, Kirking of the Tartans, Clan Challenge, and the Parade of the Tartans. See the Clan and Tartan information tents along with many colorful Scottish shops.
P...read more
Country Living Fair
10/23/2015 - 10/25/2015
See the pages of Country Living magazine come to life during the Country Living Fair featuring antiques, artisans, gifts, home décor, jewelry and more from Country Living editors, contributors, and special guests! Join nearly 150 amazing antiques dealers and artisans for a weekend of great shopping, free seminars, demonstrations and fantastic food. Vehicle entry to the park is $15 for a one-...read more


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SCO Linux 4
SCO Linux 4 is licensed on a per-server basis, with four levels of support: base for $599, classic for $699, business for $1,249 and enterprise for $2,199. This price structure is similar to Red Hat Advanced Server's, but it is slightly less expensive at each price level. (At press time, Red Hat announced a lower server price point: Red Hat Enterprise Linux ES Base Edition is $349.)
UnitedLinux 1.0, upon which SCO Linux 4 is based, has some rough edges. SCO hasn't smoothed them out yet, and their available documentation isn't much better than you can get by surfing the Internet. On the other hand, with Webmin and APT, it should be easy to keep your servers humming once you do have them set up. Except for that one scary security situation, the tech support is good.
Steve R. Hastings first used UNIX on actual paper teletypes. He enjoys bicycling with his wife, listening to music, petting his cat and making his Linux computers do new things.
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No. 12 Michigan comes from behind to put down Michigan St.
EAST LANSING, Mich. (AP) -- Michigan trailed Michigan State by 10 points midway through the fourth quarter Saturday, making it deafening in Spartan Stadium.
Mike Hart insisted he started laughing.
"Sometimes, you get your little brother excited when you're playing basketball -- let them get the lead," he said. "And then you come back."
Michigan continues to turn around its season since dropping its first two games, including the season-opening home loss to Appalachian State.
First 2 games
Last 8 games
Total YPG allowed
PPG allowed
The 12th-ranked Wolverines (No. 15 AP) did just that.
Chad Henne's 31-yard touchdown pass to Mario Manningham with 2:28 left lifted Michigan to a 28-24 win over the Spartans, its sixth straight against the Wolverines' in-state rivals for the first time since the 1970s.
"We were saying all game that they couldn't stop Mario," Henne said. "He was beating their corner every play."
The Spartans, who overcame an 11-point deficit at halftime to make it 24-14 with 7:40 left, drove to the Michigan 34 on the final drive before turning the ball over on downs.
"I thought we had the game, but it slipped away," Michigan State coach Mark Dantonio said.
Michigan (8-2, 6-0) has won eight straight since opening the season with a stunning loss to Appalachian State and a rout by Oregon.
Michigan State (5-5, 1-5) has lost five of six after starting the season strong in Dantonio's first season.
"This hurts the most because I felt like we had it," running back Javon Ringer said.
Henne tied a school record with four TDs, the last two in the final 6:47.
"Chad won the game for us," Hart said. "It should quiet the naysayers because no other quarterback could've led a comeback like that."
Henne was 18-of-33 for 211 yards with one interception after missing the previous game with a shoulder injury. Manningham caught eight passes for 129 yards.
Before Henne boarded the bus with his right shoulder wrapped with ice, a reporter asked if the win made him feel any better.
"No," he said. "It really hurts."
Michigan coach Lloyd Carr said Henne didn't throw the ball in practice, but threw some to the trainer Thursday.
"If you want to define courage, one way to do it is mention Chad Henne," Carr said.
Ringer and Jehuu Caulcrick combined for 200-plus yards rushing and three scores, but their efforts went against a trend in the 100th matchup of the rivals separated by about 60 miles.
For just the third time in 38 games, the team that ran for fewer yards won the game.
Michigan State ran for 191 yards, almost doubling Michigan's total.
Hart ran for 110 yards and was limited to 15 carries after missing 2½ games with a sprained right ankle.
Brian Hoyer missed wide-open receivers early in the game, wasting Michigan State's chances to score touchdowns.
"We had missed opportunities we needed to cash in on," offensive coordinator Don Treadwell said.
Hoyer finished 19 of 35 for 161 yards with one TD and an interception.
Ringer ran for 128 yards, including a spectacular 72-yard run to end the third quarter.
He ran to the left and after being spun around by Shawn Crable near the sideline, reversed field and sprinted up the other sideline before being brought down inside the 10 by Crable.
"People who saw this game saw a lot of great plays by a lot of great players," Carr said.
On the next snap, Hoyer threw a 5-yard TD pass to Kellen Davis for a 17-14 lead.
Caulcrick had 84 yards rushing and two scores.
The Wolverines had a scare midway through the fourth quarter when Henne appeared to turn his right ankle, stepping on a teammate's foot, but he only missed one play.
Freshman Ryan Mallett fumbled after his only snap, but Hart helped him out by picking up the ball and running for a first down.
"The turning point was when the ball came out when we blitzed Mallett, and Hart scooped it up," Dantonio said.
Henne ended that drive with a perfectly lofted pass to Greg Mathews to pull Michigan within three points just 48 seconds after the Spartans scored.
Henne drove the Wolverines down the field on their next possession and on third-and-11 connected with a leaping Manningham for the game-winning score.
The Wolverines seemed to be in control in the first half with a 14-3 lead that was closer than the game appeared to be. But they missed Hart's constant presence while the Spartans suddenly started to run the ball effectively after halftime.
Michigan State ran for just 15 yards in the first half, then ran for 137 in the third quarter alone. The Wolverines had 7 yards rushing after halftime.
Caulcrick's 1-yard run in the third and Hoyer's TD pass put the Spartans ahead. Caulcrick's second score gave them a 24-14 lead with 7:40.
After he was hired a year ago, Dantonio had clocks installed that counted down the time left before the Michigan game. Earlier in the week, he challenged his team not to be intimated by the Wolverines.
"I don't think we bowed down," Dantonio said. "We just didn't get it done at the end of the game.
"I give credit to Henne. He went up top and hit it."
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NCAAF News
Steve Spurrier announces resignation
Steve Spurrier, the visor-slinging, slick-talking "Head Ball Coach" who is the second-winningest coach in Southeastern Conference history, announced his resignation on Tuesday.
USC AD Pat Haden: 'The decision I made didn't work out, and I own that'
USC athletic director Pat Haden spoke Tuesday about the decision to fire head coach Steve Sarkisian and called it "very difficult" while also defending his handling of the situation.
Longhorns mascot Bevo retiring to ranch after cancer diagnosis
University of Texas longhorn steer mascot Bevo XIV has been diagnosed with cancer and will retire. The steer, whose given name is Sunrise Studly, was diagnosed with bovine leukemia virus.
John Kelly released after going to hospital as precaution
Tennessee running back John Kelly was taken to the hospital as a precaution and released after getting hurt during the Volunteers' Tuesday afternoon practice.The injury was not specified.
Steve Sarkisian reportedly enters treatment amid groundswell of support
Steve Sarkisian has been plagued of late by apparent substance-related circumstances, including arriving to team facilities appearing intoxicated Sunday, according to sources.
Investigators: Witness saw ex-Texas A&M WR Thomas Johnson kill jogger
A former Texas A&M football recruit randomly attacked a jogger, using a "large-bladed knife" to repeatedly strike the man and lodging the weapon in his head, according to police documents.
2015 Big Ten - East Standings
|Michigan State
|Ohio State
|Penn State


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Feiba Vh
Antibiotics Aren't Always the Answer »
"Antibiotics do not fight infections caused by viruses like colds, flu, most sore throats, bronchitis, and many sinus and ear infections. Instead, symptom relief might be the best treatment option for viral infections.
Get smart about when a"...
Feiba Vh
Some viruses, such as parvovirus B19 or hepatitis A, are particularly difficult to remove or inactivate at this time. Parvovirus B19 most seriously affects pregnant women or immune-compromised individuals. Symptoms of parvovirus B19 infection include fever, drowsiness, chills, and runny nose followed about two weeks later by a rash, and joint pain. Evidence of hepatitis A may include several days to weeks of poor appetite, tiredness, and low-grade fever followed by nausea, vomiting, and pain in the belly. Dark urine and a yellowed complexion are also common symptoms. Patients should be encouraged to consult their physician if such symptoms appear.
Last reviewed on RxList: 10/7/2008
This monograph has been modified to include the generic and brand name in many instances.
Feiba Vh FDA Prescribing Information
Additional Feiba Vh Information
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
Women's Health
Find out what women really need.


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Little-Known Companies With Lots of 'Precious Assets'
(SAND), which is the most recent success story among the few precious metals royalty-streaming companies. In fact its CEO comes from the wildly successful Silver Wheaton (SLW), which is my single favorite way to play the prospect of silver rising to new all-time highs in the months and years ahead. Jim Cramer recently interviewed the CEO of Sandstorm and it tells the colorful facts on why this company is another "goose that lays the golden egg."SAND hit a 52-week high on Oct. 8 of $15.43 and on Oct. 9 sold off 6.64% on over 2.4 million shares traded to close at $14.07. This may be the beginning of the much anticipated correction of this amazing stock. Look at this one-year price chart including the stock's 200-day moving average, which illustrates how far this stock has skyrocketed. It really needs to come back down to earth and I hope to begin accumulating shares when it gets closer to $11, if indeed it corrects that much. After Sandstorm reported its stellar 134% year-over-year quarterly earnings growth (as of June 30) only a few analysts and investment educators like Jim Cramer realized how an outstanding business model like SAND creates such remarkable results. The Vancouver-based company focuses on completing gold purchase agreements with gold mining companies that have advanced stage development projects or operating mines. The company also engages in mine financing business, as well as provides an alternative to gold mining companies in search of capital. It offers cash payment to gold mining companies and in exchange receives the right to purchase a percentage of the gold produced for the life of the mine at a fixed price per ounce. It is one of only three publicly-traded companies that capitalizes on this highly lucrative opportunity, and the best years for these three -- Franco Nevada (FNV) and Royal Gold (RGLD) being the other two -- are directly ahead. As the central banks of the world do all they can do revive the shaky global economy through massive monetary easing and dilution of their paper currencies, gold and silver are likely to go to yet-to-be realized levels. So will the cost of feeding the world. Those are just some of the reasons why I'm bullish on companies like Sprott Resources and Sandstorm Gold. Accumulate them while they're correcting and after you've had a chance to convince yourself that these two companies would be precious assets in your portfolio. As of the time of publication the author has a position in SCPZF. This article was written by an independent contributor, separate from TheStreet's regular news coverage. Jim Cramer and Stephanie Link actively manage a real money portfolio for his charitable trust- enjoy advance notice of every trade, full access to the portfolio, and deep coverage of the latest economic events and market movements.Speaking of gold, the other little known company that's making a big name for itself is Sandstorm Gold
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Paulo Ferriera told UEFA.com of his relief after Chelsea FC progressed to the semi-finals at the expense of FC Rubin Kazan, who can be proud of their 5-4 aggregate defeat according to Alan Kasaev.
© 1998-2015 UEFA. All rights reserved.
The UEFA EUROPA LEAGUE word, the UEFA Europa League logo and the UEFA Europa League trophy are protected by trade marks and/or copyright of UEFA. No use for commercial purposes may be made of such trade marks. Use of UEFA.com signifies your agreement to the Terms and Conditions and Privacy Policy.


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Back to Previous Page
The Boss 302 returns to the road after 42 years.
Shaking Hands With The Devil
In this video the Flex picks off a modded Mustang GT.
Make Your "Five-Oh" Go Faster and Smoother
If you love Ford performance, this is the place for you!
We put together some of our favorite articles about the Ford Mustang!
King of the Road
A Race Car For The Streets
Born on California's highways, the Mustang SSP offered police a high-performance alternative.
How to get up-close and personal to find the finest Ford Mustang you can afford.
A visual guide to telling one vintage Pony Car from its model-year stable mates.
Mustang's third body style emerges.
A visual feast for Mustang lovers.
A Real Jekyll & Hyde Ride
Upgrading a 1966 Mustang's Baer system from two-piston PBR caliper to six-piston Baer caliper.
Daytona Speedway was a fitting corral for these ponies.
Tulsa Raceway Park thundered with Ford power!
Carving corners with Ford power!
Walking around the paddock at Hallett Motor Racing Circuit
The Ultimate Ford Family Reunion
Fords invade downtown Tulsa's Brady Arts District
Walking around Tulsa Raceway Park
The capstone of a great event.
Families, fun and Mustangs at Myrtle Beach.
'Mustang Alley,' the 'Stone Soup Boss 5.0' and more make the 18th Woodward Dream Cruise a Ford-ified success
Packing a 550hp supercharged V8 Jaguar's super-sized flagship delivers performance & comfort with serious authority.
Big, round fenders set these rides apart from their skinny cousins.
A fitting finale for an amazing Ford filled event!
American iron wasn't all that was on the show field.
Tail fins from mild to wild were on display this year.
Do horses of a feather flock together?
Once again RM delivers with $26.8 million in sales and an impressive list of vehicles.
Some Show Cars Defy Description
We Interview Fast Five's Car Coordinator Dennis McCarthy
Big block, small block, mod motor, boosted, blown or just plain wild!
The best old haulers of SEMA
Dodge's retro styling is a natural canvas for SEMA show car modifications.
New Power For Old Iron
Check out Bryan's latest project on Cafe Racer TV.
Don't be fooled, it takes a lot of work to look this cool.
It takes a special kind of truck to haul this much attitude.
The Florida heat had nothing on these paint jobs.
Our Editor Brian Medford picks his favorite cars of the show.
From across the Atlantic these rides bring their own brand of attitude.
The biggest show in the automotive aftermarket doesn't disappoint!
These show stoppers are the heart and soul of the event!
These heavy haulers drew just as much attention as their downsized brothers.
Love them or hate them, rat rods were on the prowl in Minnesota.
"Why yes, there is a Hemi in it."
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From Our Editors
Main Street Car Wash has been owned and operated by the same family for more than a quarter century, adding pizzazz to rides with sudsing and detailing services. With names honoring the owner's children, Amy and Max, the service menu includes three to four tiers of washing and detailing treatments, whether for a vehicle looking to dust off for the spring or inconspicuously crash a limo's birthday party. Drive-thru or hand-washing treatments can be augmented with add-ons such as leather cleaning and conditioning, triple-foam wax treatments, Rain-X application, and vacuuming. Hand-applied wax treatments envelop automobiles in paint protection for three to six months, and each receipt comes loaded with $25 in coupons for future services, allowing guests to extend their car's sparkling façade well into the future.
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Drink Drank Drunk Videos, Drink Drank Drunk Pictures, Drink Drank Drunk Articles
BASWNAOC season 2
Drunk History Vol. 1 - Featuring Michael Cera
On August 6th 2007, Mark Gagliardi drank a bottle of Scotch... And then discussed a famous historical event. That night history was made...Drunk History
Drunk History vol. 2 - Featuring Jack Black
A Benjamin Franklin expert reveals his controversial theory about the discovery of electricity. Witness history told as it's never been told before...Drun...
Drunk History vol. 2.5 - Featuring Jack Black
Later that night Eric Falconer, the Franklin expert, drank more vodka and then discussed this historical event... Derek Waters presents Drunk History vol....
Drunk History vol. 3 - Featuring Danny McBride
Watch the gripping tale of Oney Judge, George & Martha Washington's favorite slave. Late one night Jen Kirkman drank a bottle and a half of wine and then ...
Day Drunk: Is it Ok?
I need everybodies help! I'm writing a paper for school on when it is ok to get drunk during the day. So tell what you think and include stories...you cou...
Drinking At Church w/Gangstas
(26 of 99 Chapters) Got drunk and stoned in a church parking lot. You can have a good time anywhere!
Drunk in Helsinki
Being drunk in Helsinki looks like a lot of fun but it also looks like a tough place to stand up when you're very very drunk.
Drunk Christian Mythology
After being woken up from an alcohol induced comma, Josh retells his favorite bible story. The story of Joshua as told by Joshua.
Things not to say to a girl while speed dating…In order of drinks I consumed.
I got signed up to speed date by the guys at RadioAwesome and I drank like a Somali pirate on holiday.
I Sleepwalk And Pee!
(1 of 99 Chapters) It's true. Not just for young people. I happens to all people who drink!
Took My Kid To The Mall
(21 of 99 Chapters) My ex-wife finally let me see my kid! He just turned 8. I didn't drink or anything and had a blast!
Nick Swardson Stand Up Jokes source: http://www.jokes4us.com/peoplejokes/comedianjokes/nickswardsonjokes.html
Why would somebody worship the devil?... Has the devil paid off for anybody ever? What was the last award show you saw where somebody won and they came out ...
My Valentine I Miss You!
(14 of 99 Chapters) Got drunk and missing someone who was once very important in my life a long time ago. Very Serious about this one.
Banned PSA - Uncut and Uncensored
Things sometimes don't go as planned. Brett Eidman should start drinking.
My Vagisil Commercial
(27 of 99 Chapters) Spring cleaning!
I Fell In Love Mofos
(29 of 99 Chapters) There's a lady who has captured my heart.
Night Ranger Bouncer Fight
(11 of 99 Chapters) Sister Christian Is My Favorite Song. They ruined it!