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Chemical Attenuation of Plasmodium berghei Sporozoites Induces Sterile Immunity in Mice
ABSTRACT Radiation and genetic attenuation of Plasmodium sporozoites are two approaches for whole-organism vaccines that protect against malaria. We evaluated chemical attenuation of sporozoites as an alternative vaccine strategy. Sporozoites were treated with the DNA sequence-specific alkylating agent centanamycin, a compound that significantly affects blood stage parasitemia and transmission of murine malaria and also inhibits Plasmodium falciparum growth in vitro. Here we show that treatment of Plasmodium berghei sporozoites with centanamycin impaired parasite function both in vitro and in vivo. The infection of hepatocytes by sporozoites in vitro was significantly reduced, and treated parasites showed arrested liver stage development. Inoculation of mice with sporozoites that were treated in vitro with centanamycin failed to produce blood stage infections. Furthermore, BALB/c and C57BL/6 mice vaccinated with treated sporozoites were protected against subsequent challenge with wild-type sporozoites. Our findings demonstrate that chemically attenuated sporozoites could be a viable alternative for the production of an effective liver stage vaccine for malaria.
Full-textDOI: · Available from: Terry W Spithill, Sep 28, 2015
- SourceAvailable from: Barbara Capuccini
- "The lack of significant progress with subunit vaccines that contain only (parts of) single proteins, together with an enhanced understanding of the protective immunity to malaria has generated new interest in vaccines based on whole blood stage parasite49. Sporozoites that have been attenuated either by radiation or by genetic modification have shown promise as a whole parasite approach to pre-erythrocytic vaccination505152535455. Recent studies have demonstrated that the disruption of individual genes was not sufficient to completely attenuate parasite virulence. "
Article: Disruption of plasmepsin-4 and merozoites surface protein-7 genes in Plasmodium berghei induces combined virulence-attenuated phenotype[Show abstract] [Hide abstract]
ABSTRACT: Blood stage malaria parasites causing a mild and self limited infection in mice have been obtained with either radiation or chemical mutagenesis showing the possibility of developing an attenuated malaria vaccine. Targeted disruption of plasmepsin-4 (pm4) or the merozoite surface protein-7 (msp7) genes also induces a virulence-attenuated phenotype in terms of absence of experimental cerebral malaria (ECM), delayed increase of parasitemia and reduced mortality rate. The decrease in virulence in parasites lacking either pm4 or msp7 is however incomplete and dependent on the parasite and mouse strain combination. The sequential disruption of both genes induced remarkable virulence-attenuated blood-stage parasites characterized by a self-resolving infection with low levels of parasitemia and no ECM. Furthermore, convalescent mice were protected against the challenge with P. berghei or P. yoelii parasites for several months. These observations provide a proof-of-concept step for the development of human malaria vaccines based on genetically attenuated blood-stage parasites.Scientific Reports 07/2011; 1:39. DOI:10.1038/srep00039 · 5.58 Impact Factor
- "Infected midguts and/or salivary glands were dissected on ice (Purcell et al., 2008). Hemocoel was dissected using volume displacement (perfusion) essentially as previously described (Hillyer et al., 2007). "
Article: A putative kinase-related protein (PKRP) from Plasmodium berghei mediates infection in the midgut and salivary glands of the mosquito[Show abstract] [Hide abstract]
ABSTRACT: The completion of the Plasmodium (malaria) life cycle in the mosquito requires the parasite to traverse first the midgut and later the salivary gland epithelium. We have identified a putative kinase-related protein (PKRP) that is predicted to be an atypical protein kinase, which is conserved across many species of Plasmodium. The pkrp gene encodes a RNA of about 5300 nucleotides that is expressed as a 90kDa protein in sporozoites. Targeted disruption of the pkrp gene in Plasmodium berghei, a rodent model of malaria, compromises the ability of parasites to infect different tissues within the mosquito host. Early infection of mosquito midgut is reduced by 58-71%, midgut oocyst production is reduced by 50-90% and those sporozoites that are produced are defective in their ability to invade mosquito salivary glands. Midgut sporozoites are not morphologically different from wild-type parasites by electron microscopy. Some sporozoites that emerged from oocysts were attached to the salivary glands but most were found circulating in the mosquito hemocoel. Our findings indicate that a signalling pathway involving PbPKRP regulates the level of Plasmodium infection in the mosquito midgut and salivary glands.International journal for parasitology 03/2010; 40(8):979-88. DOI:10.1016/j.ijpara.2010.02.010 · 3.87 Impact Factor
Conference Paper: User-oriented universal design in parks of urban waterfronts[Show abstract] [Hide abstract]
ABSTRACT: Affordance concept is applied to understand the relation between users' behaviors and affordances of marine environments and supports the universal design. Marine environments have not only several positive action possibilities, but also behavior constraints. Users' preferences on the environments share similarities and show differences.OCEANS '04. MTTS/IEEE TECHNO-OCEAN '04; 12/2004


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BMI Industry View : The Dutch medical device market is expected to expand at a subdued rate over the next five years with a US dollar CAGR of 3.2% forecast for the 2013-2018 period. Despite downward pressure on costs, health expenditure is forecast to grow steadily due to the needs of the rising elderly population and this will be a primary drive r in the market, although low economic growth and the austerity programme proposed by the new coalition government are likely to hold down growth rates. The operating environment within the healthcare sector is set to become even more competitive as a result of the government's latest reform programme, although this should favour more innovative forms of technology that offer cost saving features, particularly given the Health Ministry's proposals to support faster uptake of promising innovations.
Headline Industry Forecasts
The Netherlands has a well developed, comparatively mature medical device market, which is valued at USD3.8bn in 2013, equal to USD225 per capita. The market is expected to grow by a 2013-2018 US dollar CAGR of 3.2% over the next five years, reaching USD4.4bn in 2018, equal to USD261.
Medical device imports supply the greater part of the market, although the total value of imports far exceeds the value of the domestic market due to the country's status as a distribution hub for European markets, resulting in a high level of re-exporting in many product areas. Import activity was broadly flat in 2014 with imports valued at EUR10.5bn, unchanged from 2013, according to Eurostat annual trade data. In US dollar terms, imports rose by 0.7% to USD14.0bn. We anticipate a return to growth in euro terms in 2015, but the continuing depreciation of the euro against the US dollar is likely to weigh on US dollar values.
Medical device export performance has deteriorated since the start of 2015, having achieved mid single-digit growth in 2014. According to Eurostat annual trade data, exports grew by 4.2% to EUR14.3bn and by 4.3% to USD19.0bn in 2014, but growth has been negative in both currencies during Q115. Currency weakness will continue to impact performance during 2015 with the euro forecast to fall to near parity with the dollar by the end of the year. The Netherlands has a sizeable balance of trade surplus, which amounted to USD5.0bn in 2014, with diagnostic imaging and consumables the main contributors.
Domestic production ranges from small independent manufacturers to multinational corporations such as Philips Healthcare. Reported medical device production is comparatively low at less than USD550mn, although this only represents a fraction of overall medical device output, as data is not available on the grounds of confidentiality for key sectors where there are a low number of producers, including diagnostic imaging and most consumables.
Headline Industry Risk/Reward Index
The Netherlands is the seventh most attractive market in the Western Europe (WE) region in which to commercialise a medical device, according to BMI's Medical Device Risk/Reward Index (RRI). The country's overall score for Q315 is 72.6 out of 100, unchanged from Q215, compared to a regional average of 72.1 for the 15 key markets covered.
Headline Healthcare Overview
The population of 16.8mn inhabitants is the sixth largest in WE and is growing at an annual rate of 0.3%. Around 17.6% of the population is aged 65 years and over. Life expectancy at birth is estimated at 79.6 years for men and 83.1 years for women in 2014.
At 11.2% of GDP, the Netherlands has one of the highest rates of health spending in WE. In 2014, we estimate healthcare expenditure at USD98.2bn. In July 2013, the Health Ministry agreed a package of measures with healthcare providers to cut EUR1.0bn from forecast healthcare spending as part of the government's proposed EUR6.0bn austerity programme. The agreement allowed for a 1.5% rise in healthcare spending in 2014 and a 1.0% increase between 2015 and 2017.
The Netherlands has a long history of providing accessible healthcare, although resources are comparatively low for a WE country. There were an estimated 3.1 hospital beds and 2.0 doctors per thousand population in 2014. In contrast, the number of nurses is above average for the region at 10.3 per thousand population. The number of hospital beds is gradually declining, whilst the number of medical personnel is increasing steadily with growth led by doctors.
Headline Industry Trends & Developments
Medical device imports fell by 10.6% to USD3,105.0mn in Q115. All product areas contracted during the quarter with falls ranging from 0.2% for patient aids to 32.1% for dental products.
Medical device exports fell by 19.4% to USD3,739.4mn in Q115. All product areas contracted during the quarter with falls ranging from 3.4% for dental products to 41.9% for consumables.
Spending on health services within the health insurance system rose by 2.0% in 2014 to reach EUR37.6bn (USD50.4bn), according to figures from the Dutch Care Institute (NZi).
Health Minister Edith Schippers has presented details of a revised version of her healthcare bill, which the government has been forced to amend after the first version was unexpectedly voted down by the Senate in late December 2014. The bill seeks to make savings of EUR1.0bn through the introduction of a cheaper medical insurance package by 2016.
Major changes to the system of long term care are to be implemented in 2015 with the reform of the Social Support Act which gives more responsibility for care to the municipalities and restricts the right to residential care to those needing 24-hour supervision.
Around one in five hospitals are struggling financially, with smaller hospitals under the most financial pressure. This is the finding of a study by the healthcare division of the accounting and consulting firm BDO, which analysed the 2013 annual reports of 74 general hospitals in the Netherlands.
A national medical implants registry was officially launched in January 2015, following completion of a pilot trial conducted in 2014.
Ion Beam Applications and Varian Medical Systems have each received orders to install proton beam therapy systems at the first two proton therapy centres being set up in the Netherlands, which are due to start treating patients in 2017.
A Dutch consortium, including medtech start-up Xeltis, has received EUR4mn (USD4.4mn) to develop a new way to generate an autologous blood vessel inside the body for kidney dialysis. Xeltis has also raised EUR27mn (USD30mn) in funding to finance development of the company's product pipeline based on Endogenous Tissue Growth technologies, including a pulmonary heart valve.
The merger of Amsterdam-based Tornier with Wright Medical Group has received shareholder approval and is now expected to close in Q315. The new company will be called Wright Medical Group NV and will be incorporated in the Netherlands, where Tornier has been headquartered for the past eight years.
Philips has reported a 4.1% fall to EUR9,186mn in 2014 sales at its Healthcare division, a fall mainly caused by operational issues and soft markets. Philips Healthcare's struggles will continue in H115, although the creation of a standalone Health & Wellness business and the acquisition of Volcano Corporation will serve Philips Healthcare well in the long-term.
Philips Healthcare and Leiden University Medical Centre have entered into a research collaboration aimed at improving preventative and chronic care through wearable technologies.
BMI Political View : As expected, the Dutch grand coalition government has officially lost its majority in the legislative upper house following provincial elections in March . This will result in a period of legislative deadlock, making it harder for Prime Minister Mark Rutte's government to push through its increasingly unpopular austerity and structural reform agenda, and raises the probability that the government stands down before the end of its mandate in 2017. The government has already been forced to make concessions to its contentious healthcare reform bill after it was blocked in the Senate. The bill seeks to cut health spending by EUR1.0bn through the introduction of a cheaper medical insurance package by 2016, as part of the government's plan to reduce its deficit to below 3.0% of GDP, in line with European Union rules. 2015 will see significant structural reform in the healthcare sector with long term healthcare support restricted to those most in need. A large part of less urgent care is being decentralised to the municipalities or shifted to the mandatory health insurance system as available budgets are scaled down. This is expected to result in structural savings of EUR2.5bn.
BMI Economic View : The Dutch economy has entered a cyclical growth upswing . Initial estimates for headline real GDP growth in Q115 show that the Dutch economy expanded 2.4% y-o-y, the largest exp ansion in real terms since Q208 . While net exports will remain the key determinant of the Netherlands' growth trajectory, consumer spending, which has been a drag on growth over the past few years, will also help drive a well-balanced growth acceleration over the next two years, supported by strong disposable income gains, which have been boosted by cheap energy prices. As a result, we have upgraded our headline growth forecasts for 2015 and 2016 to 1.6% and 1.8% respectively. While this is slightly above average for the eurozone as a whole, this is some way below the Netherlands' pre-crisis average growth rate of around 2.5%.

subset: commoncrawl


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John Sindelar thinks so – and to prove it he is selling 90% of his incredible collection...
of hand-crafted woodworking tools. Popular Woodworking posted a story about the sale and a video (see below) of the collection. If you like seeing old and one-of-a-kind tools then I encourage you to visit John's website. His collection includes saws, tool chests, Stone Age and medieval tools, Asian tools, and every kind of plane. He has some really crazy stuff.
25 favorites from the outgoing editor.
Tools and Equipment
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Twice the batteries, twice the voltage, and more than twice the speed of the...
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Here are ten points to consider in the current EMU Listening Process: 1. Hate and homophobia are pervasive in American culture. School kids call each other "fags" and insult people by calling them "gay." Bullies of all ages beat up… Read More ›
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Linking Fortunes: From Those of the Top to the Bottom
St. Mary's College of Maryland is considering a radical proposal to link the college president's salary to the lowest-paid worker. If approved, the president's salary could be no more than ten times greater than the lowest-paid employee. At a time… Read More ›
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Dear writer of "Where are the Opposing Voices," Due to your letter being sent anonymously, it is difficult to tell if you are faculty, staff, or student. I am a member of the staff and have been for more than… Read More ›
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The Listening Process these past few months has been a blessing, a frustration, and a ________ (you fill in the blank). We have all been invited and pushed into it from different angles and might find ourselves on different places… Read More ›
A Letter of Reasons: Jesus, Scripture, Church, Biology
I wish to add my voice to those who believe that it is morally wrong for EMU to change their hiring policy to include faculty/staff who are in covenanted same-sex relationships. Reasons for my opposition can be summed up in… Read More ›
U.S. Farming Exploitation and How to Get Around It
One farm worker dies on the job every day in America.1 In 2013, the average tomato harvester was earning 50 cents for every 32 pounds of tomatoes he/she picked, a rate that hasn't changed in over thirty years.2 In December… Read More ›
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There is a place not far from where we live, a place indescribable and inescapable, where those fairy- tale beings live: giants, witches and princes. To Carl Jung, and to Joseph Campbell, this place was called the "collective unconscious,"… Read More ›
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It has come to my attention that there is a fundamental flaw with education on this campus. We claim to know the Bible and we use its verses in our arguments and discussions, but we have not properly trained our… Read More ›


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REGULATION OF TRANSCRIPTION FACTOR STAT5 IN THE.ppt
Then DNA (genomic DNA, and mitochondrial DNA) can be isolated from the fin tissue by several step of enzyme digestion, centrifugation and organic extraction ...
DNA Sequencing - Windward Community College.ppt
DNA Sequencing From Extraction to Information The Process Step 1: DNA Extraction Genomic DNA extraction from the organism (bacteria) Step 1: DNA Extraction Step 2 ...
Vectors for Even Larger Genomic DNA Inserts.ppt
Bacterial Physiology (Micr430) Lecture 8 Macromolecular Synthesis and Processing: DNA and RNA (Text Chapter: 10) ... Down
Vectors for Even Larger Genomic DNA Inserts
Bacterial Physiology (Micr430) Lecture 8 Macromolecular Synthesis and Processing: DNA and RNA (Text Chapter: 10)instructional1.calstatela.edu/hxu3/Micr430/W09micr430Lec8.ppt
Quiz 1. When was the term genomics first coined? A. In 1953 after Watson and Crick published a paper on the structure of DNA. B. In 1975 after DNA sequencing began ...www.commed.vcu.edu/.../genetics/2014/Genomics14.pptx
Genomic´s Future: Our Future?
Genomics: Quick Introduction. History: >Mendel'slaws of heredity >Recognition of DNA as genetic material >DNA Structure >Geneticcode >Recombinant DNA technologiesbioinformatica.uab.cat/base/documents/Genomics/Genomic´s2015_1...
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Town Square
Saturday: Education foundation auction
Original post made on Apr 20, 2012
Read the full story here Web Link posted Friday, April 20, 2012, 11:04 AM
Comments (3)
a resident of Atherton: other
on Apr 20, 2012 at 12:27 pm
Wouldn't it be nice if help was offered to Selby Lane School in Atherton as well? They could always use assistance.
a resident of Menlo Park: Fair Oaks
on Apr 20, 2012 at 1:54 pm
I'm sorry...but Selby Lane is in the Redwood City School District and they have their own Foundation.
Can't we just celebrate that so many volunteers and families care about our children?
a resident of Menlo Park: Belle Haven
on Apr 20, 2012 at 9:13 pm
I hope Dr. Ghysels brings his guitar and sings a few songs for us!
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Rhode Island ranked eighth in the nation in terms of jobs lost to China from 2001 to 2013, according to a study released by the Economic Policy Institute on Thursday. more
By PBN Staff
Rhode Island exports increased 34 percent from August to September to $245 million from $182.9 million, according to the latest report from e-forecasting.com. more
By PBN Staff
Rhode Island again ranked 20th among the 50 states in export growth for the first eight months of 2014, posting a 5.1 percent increase in foreign sales compared with the prior-year period, according to e-forecasting.com. more
By PBN Staff
Don't let the small mountain of coal overlooking the Port of Providence fool you. more
By Patrick Anderson
Passenger traffic declined in September at T.F. Green Airport, registering 297,077 travelers, a drop of nearly 6 percent compared with September 2013, according to the latest report released by the R.I. Airport Corporation. more
By PBN Staff


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Top Definition
An edited compilation consisting of only the fight scenes from a film. All plot and context is removed.
Hey Mike the Huge, have you seen the complete Tony Jaa Allfight? It's 90 minutes of pure fighting from Ong Bak I-III and The Protector!!
by T. Jaa May 15, 2011


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The Wildkin Big Dot Red & White Nap Mat brings a symmetric design to a comfortable nap mat. The attached blanket and included storage bag and pillow keep the bright red theme and bring some convenience, too.About WildkinUnpacking the world of children's luggage, Wildkin offers a wide collection of outrageously fun and fantastically practical bags, backpacks, mats, sleeping bags, and more. Each Wildkin piece is available in over 30 unique patterns so parents can be sure to match


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Blog: Why your CV is no longer enough
Click here for the hard truth about the current job marketAugust 31, 2015 8:50
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MIDEAST STOCKS-Markets to rise on stronger global environment
Abu Dhabi's ADWEA in talks with banks for $350 mln project bond
Emirates hints at no Dubai Airshow orders, pushes decision on A350/787 to next year
UAE minister says plans to boost oil output capacity on track
MIDEAST STOCKS-Saudi, Egypt markets barely move in early trade
Qatar Q2 GDP growth accelerates to 4.8 pct year/year
UAE says reforms will better protect foreign workers
United Arab Bank secures $125 mln three-year loan
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MIDEAST STOCKS-UAE markets narrowly mixed in thin, early trade
Fresh rumours have surfaced about Apple's much awaited iPhone 5. Will Apple have what it takes to crush its rival, the Galaxy S3 or will Android lovers take over the world?
July 17, 2012 7:09 by Muhammad Aldalou
The rumour mills are churning and it's gotten all tech lovers extremely excited. The iPhone 5 frenzy is here as another predicted date of its release has been leaked out. Earlier, it was rumoured that it would be released in October but now the date has been moved to August 2012.
The two main questions that are caught in the cobwebs of every tech geek are; is it an enormous improvement from the iPhone 4S and does it compare to the Galaxy S3 which has been described as one of the best smartphones in the world? It is also considered to be one of the fastest selling Androids in 2012.
For Android fans, what most reviewers are saying will get their blood boiling; because the general vibe is that the iPhone 5 will severely cut out Samsung's latest marvel. The latest iPhone model which is iPhone 4S is one of the top-selling smart phones in the world.
The iPhone 5 is said to be much taller as compared to iPhone 4S due to the rumoured taller screen for iPhone 5. The iPhone 4S is around 115.2mm tall and the iPhone 5 is said to be around 120mm tall. In terms of thinness, the iPhone 5 will be much thinner with 7.99mm as compared to iPhone 4S which is around 9.3mm.
Where most analysts will agree, an area where the Samsung Galaxt S3 has drawn a fair amount of criticism is with its design. The phone is an attractive device but it neither feels or looks like the flagship model that it is supposed to be. The extensive use of plastics on the phones body cheapens the feel of the handset.
The common opinion of tech geeks, reviewers and analysts is unanimous, that if the iPhone 5 is anywhere near the video below then it will surely embarrass the Galaxy S3.
Judging by social media reports, blogs and general opinions many users feel that the Galaxy S3 is definitely a tempting device but curiosity for the iPhone 5 is getting the better of them. However, nobody can make an informed decision until Apple's anticipated device is officially released. Bottom line is, Samsung better have a strong rebuttal against this.
Yemen's Maarib oil pipeline resumes flows
July 17 2012
INTERVIEW: Global picture getting scarier
July 18 2012


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VIDEO: New Trailer for THE NUMBERS STATION Released
The official trailer for THE NUMBERS STATION, starring John Cusack and Malin Akerman, hasa just been released. Check it out below!
Directed by Kasper Barfoed and written by F. Scott Frazier, THE NUMBERS STATION is officially described as:
"After his latest mission goes disastrously wrong, veteran CIA black ops agent Emerson Kent (John Cusack, 2012) is given one last chance to prove he still has what it takes to do his job. His new assignment: guarding Katherine (Malin Akerman, Watchmen), a code operator at a top-secret remote CIA "Numbers Station" where encrypted messages are sent and received. When an elite team of heavily armed assailants lays siege to the station, Emerson and Katherine suddenly find themselves in a life-or-death struggle against an Unknown enemy. With the station compromised and innocent lives at stake, they must stop the deadly plot before it's too late."
THE NUMBERS STATION is set to hit theaters on April 26.
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Mario Draghi News
Protestor Glitter Bombs European Central Bank President
President Mario Draghi was in the middle of a speech when an activist jumped onto the table and dumped glitter on his head, screaming "end the ECB dictatorship."
Protester Unexpectedly 'Glitter Bombs' European Central Bank President
out of nowhere and "glitter bombed" him. President Mario Draghi had just began explaining how smoothly the ECB's stimulus ..... entering the building," the ECB added. "ECB President Mario Draghi remained unharmed and calmly proceeded with the press
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overnight for the first time in over two years in an effort to boost slowing growth. European Central Bank President Mario Draghi rallied markets with his speech at the Euro Banking Congress where he strongly emphasized the ECB's intentions to
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from parliament on Wednesday for austerity measures to receive needed aid. Meanwhile, European Central Bank president Mario Draghi said the Eurozone crisis was weighing on Germany's economy. 2. Healthcare "The good news is that the Affordable
Stocks Reach Four-Year High; Good News for Obama?
since December 2007 to 13,292, up almost 2 percent. Earlier today, the president of the European Central Bank, Mario Draghi , announced the bank would allow unlimited purchases of government bonds. The policy is a bold attempt to cut the interest
New Bond-Buying Push Aims to End Euro Crisis
The president of the European Central Bank Mario Draghi announced a new program today to make unlimited purchases of government bonds. The policy is a bold attempt to cut the interest
The Global Note: When Draghi Speaks…Terror - and Survival - In The French Alps…The Barcode Gravestone
It's not often that the world pays this close attention to a European banker - and even if you've never heard of Mario Draghi , you may want to pay attention, too. As Richard DAVIES writes, Draghi, President of the European Central Bank
Can The Euro Be Saved?
Morning Business Memo: The president of the European Central Bank, Mario Draghi , faces a stark question with his widely anticipated bond-buying program. Is it enough to save the euro? Financial markets
The Global Note: For U.S., 4 Global Nightmares…No-Fly Plea for Syria…Elephants Slaughtered…In New Zealand, Lost In Translation
China, Japan and Korea claim as their own; and (for good measure) global investors have a laser-like focus on Mario Draghi , European Central Bank chief, waiting to hear his ideas and forecasts in remarks coming Thursday. Anything less than
United Apologizes After More Computer Problems
European Central Bank is pretty blunt about the failures of the 1999 agreement that formed the single currency eurozone. Mario Draghi wrote an opinion piece in a German newspaper, saying the original setup was unworkable and there is no going back
The Global News Quiz! (All taken from this week's "Global Note")
taekwondo fighter fund his Olympic dream? ANSWERS 1) Rafalca. 2) Vladimir Putin. 3) Drones and/or paragliders. 4) Mario Draghi 5) Teddy bears. The President of Belarus Aleksandr Lukashenko fired two generals this week on charges they allowed
The Global Note: Al Qaeda In Spain?…In Syria, Horrors On Both Sides…In Belarus, Teddy Bears From The Sky
the European Central Bank holds key meetings on the Eurozone debt crisis. The meeting comes just days after ECB head Mario Draghi raised expectations for action by the central bank when he promised to do whatever it takes to save the euro. Bankers
The Global Note: Assad Fights Back…40 Bombings In Iraq…Norway & The Boss
dollar has climbed more than four percent so far this year. All this comes one day after European Central Bank President Mario Draghi told Le Monde that the Euro is "absolutely not" in danger. "The euro is irrevocable," he added. AL SHABAB SAYS
Sunday Sound: Heard on 'This Week'
panel. WILL: The White House must be petrified that the most important man in their life in some sense is a guy named Mario Draghi , who no one knows. He's the head of the European Central Bank. And he can have a vast effect on our election here
The Global Note: A Syrian Boy…Europe's Fever…Obama's Cyberwar…The Diamond Jubilee
following its worst month in 20 years. -BANKING CHIEF: EURO ZONE "UNSUSTAINABLE"...European Central Bank President Mario Draghi warned Thursday that he considers the eurozone's current structure "unsustainable," and said the region's governments
Cheaper Gas and Consumer Loans This Summer?
Dow closed down 161 points - more than wiping out the gain the day before. Tough talk from Europe's top banker. Mario Draghi , head of the European Central Bank, is calling for more centralized authority to oversee troubled banks, criticizing
Time Magazine's 2012 Most Influential List
Daniel Ek • Virginia Rometty • Barack Obama • Goodluck Jonathan • Xi Jinping • Fatou Bensouda • Christine Lagarde • Mario Draghi • U Thein Sein • Ayatullah Ali Khamenei • Mitt Romney • Juan Manuel Santos • Timothy Dolan • Portia Simpson Miller
Cruise Ship Crunch? Morning Business Memo
far above the rates in most of the world. The Chinese government is trying to cool down growth and avoid a crash. Mario Draghi , the head of the European Central Bank, says it's time for investors and regulators to rely less on ratings agencies
Morning Business Memo
enforce much stricter fiscal discipline. The plan will be considered at next Friday's European summit in Brussels. Mario Draghi , The head of the European Central Bank, says his institution could boost its role in fighting the debt crisis if eurozone
Morning Business Memo
Italian 10 year interest rates are below 7 percent. Tough talk today from the new head of the European Central Bank. Mario Draghi says the 17 eurozone nations must link their economies more tightly together – and avoid a repeat of the recent debt
Italy's Prime Minister Silvio Berlusconi Retains Power -- Barely
protesters who have already replied they will try to break the blockade. The former Governor of the Bank Of Italy, Mario Draghi , now newly-named president of the European Central Bank, warned Wednesday in a much-reported speech that 'Italy
World finance officials gather in Washington
a group that includes central bankers and major financial regulators from around the world. The panel is headed by Mario Draghi , head of Italy's central bank, who will present his group's findings to the other G-7 officials during their


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580 Geary St, San Francisco, CA, 94102, United States of America, 800 1205131 (Singapore Toll Free) +1-817-524-0058 (From abroad)
The Hotel California - A Piece of Pineapple Hospitality
Lowest priceS$340
available on 19/10/2015
Best Price Guarantee
The hotel will be renovating from 1 February 2015 to 31 October 2015 (completion date subject to change). The following areas are affected:
Renovation work will only be conducted during business hours. Every effort will be made to minimize noise and disturbance.
- Elevator
- Hallway
- Select guestrooms
Renovation work will only be conducted during business hours. Every effort will be made to minimize noise and disturbance.
Family guestrooms with comfy beds, near Union Square
- Free WiFi
Main amenities
- 93 smoke-free guestrooms
- Valet parking
- Business center
- 24-hour front desk
- Coffee/tea in the lobby
- Daily housekeeping
- Front desk safe
- Meeting room
- Concierge services
- Free newspapers in the lobby
- Luggage storage
What's around
- In Downtown San Francisco
- Union Square (0.3 mi / 0.5 km)
- Westfield San Francisco Center Shopping Mall (0.5 mi / 0.8 km)
- Lombard Street (1.3 mi / 2 km)
- San Francisco Museum of Modern Art (0.7 mi / 1.2 km)
- Asian Art Museum of San Francisco (0.7 mi / 1.2 km)
My problem was being woken up constantly in the middle of the night by the next room's…
Perfectly comfortable stay for one person (or a couple). Room was small, simple but very…
TripAdvisor Traveller Rating: 4
From 979 reviews
Enter dates to check prices
Hotel Info: 800 1205131from S$340
- Deluxe Room, 1 King Bed
- Standard Room
- Deluxe Room, 1 King Bed
- Deluxe Room, 1 Queen Bed
- Sun Room
- Standard Room, 1 Queen Bed
- Standard Room, 2 Single Beds
- Deluxe Room, 1 Queen Bed
- Suite
- Deluxe King
- Standard Room, 1 Queen Bed
- Deluxe King
- Deluxe King
- Deluxe King
- Deluxe King
Recommended hotels
At a glance
Key facts
Hotel size
- This hotel has 93 rooms
- This hotel is arranged over 7 floors
- Check-in time starts at 4 PM
- Check-out time is noon
Required at check in
- Credit card deposit required
- Government-issued photo ID required
Travelling with others
- Pets allowed (dogs only)
- 2 per room
- Free WiFi in public areas
- Free WiFi in rooms
- Valet parking *
Other information
- Smoke-free property
Nearby Three Star San Francisco hotels
In the hotel
Food and drink
- Free reception
- Coffee/tea in the lobby
Things to do
- Golfing nearby
Working away
- Business center
- Conference space size (feet) - 398
- Conference space size (meters) - 37
- One meeting room
- 24-hour front desk
- Concierge services
- Free newspapers in lobby
- Luggage storage
- Year Built 1913
- Elevator/lift
- Safe-deposit box at front desk
- Accessible path of travel
- In-room accessibility
In the room
Home comforts
- Ceiling fan
- Coffee/tea maker
- Iron/ironing board
Sleep well
- Premium bedding
- Pillowtop mattress
Freshen up
- Shower/tub combination
- Free toiletries
- Hair dryer
Be entertained
- Flat-screen TV
Stay connected
- Desk
- Free WiFi
- Free local calls
Food and drink
- Free bottled water
- Daily housekeeping
Top San Francisco hotels
Recently reviewed hotels in San Francisco
- Holiday Inn San Francisco International AirportFrom
"Had a comfortable stay at Holiday Inn SFO, and definitely worth for money."Aug 24, 2015
- Holiday Inn Express San Francisco-Airport NorthFrom
"Room is nicely decorated, spacious and clean. Reception very helpful and informative. Carpark charges is USD 9.95 per day. Car rental return is quite near hotel but not walking…"Aug 22, 2015
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"Strong plus is the 5mins to 10mins walk train station. Room is clean & comfortable. But breakfast selection is limited."Aug 18, 2015
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Nearby hotels
The Hotel California - A Piece of Pineapple Hospitality's small print
Also known as
- Best Western
- Best Western California
- Best Western Hotel California
- Best Western San Francisco
- Hotel California San Francisco
- San Francisco Best Western
Optional extras
Valet parking costs USD 35.00 per night
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.


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This has only happened with the president at Camp David, at most, a couple of times, according to a source who says he has been to the retreat on a half-dozen visits with Obama.
"The only time he shot skeet was for President's Cup," said the source, referring to a shooting competition tradition involving the presidential Marine guards. "I was there. He stayed for about five minutes, and couldn't leave fast enough."
Skeet shooting "is very hard," said the source. "Especially for someone not used to guns ... He couldn't have been more uncomfortable."


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|By Business Wire
Article Rating:
|January 30, 2013 10:30 AM EST
Comcast, a global media and technology company, today announced Comcast Business Hospitality, a new product suite consisting of Ethernet, Internet, video and voice services packaged in one integrated offering customized for the hospitality industry. Available across its entire service area, Comcast's new product suite enables hotels and motels to leverage advanced technology from a single provider to improve the guest experience, streamline back-office operations and reduce costs.
As the line between business and pleasure continues to blur for many travelers, seamless connectivity and high-speed Internet access are in high demand. With Comcast Business Hospitality, hotels and motels can provide their guests with fast and reliable Internet connectivity, quality voice services and up to 60 high-definition (HD) channels in each room – and the services scale quickly to meet growing business needs, seasonal demands and other peak usage periods.
"The needs of today's modern traveler are changing, and high-performance connectivity is now just as important as price, location and loyalty programs when selecting a hotel," said Alexandra Sewell, senior director of Hospitality Services and Cross-Segment Verticals, Comcast Business Services. "Hospitality decision makers must adapt to support this trend, and Comcast Business Hospitality offers them an easy way to do so by packaging scalable, cutting-edge technology with a fast and reliable network – without complicating back-end operations. In an extremely competitive market, this is a vital business differentiator for hotel properties."
The combination of Comcast's broad portfolio of services, high-performance network and dedicated hospitality support team make it uniquely suited to meet the needs of the hospitality industry. Comcast operates and supports its advanced network, which is separate and diverse from traditional telecom carrier networks and serves 20 of the nation's 25 largest markets. The strength and reach of Comcast's network, which is a result of decades of investments by the company, provides hotels with a reliable connection – even across geographically dispersed properties – and enables them to deliver seamless data, video and voice services, including:
- Business Hospitality Ethernet – Provides fast, reliable and secure network connectivity and scalable bandwidth from 1 Megabit per second (Mbps) to 10 Gigabits per second (Gbps). Hospitality organizations can easily and quickly adjust their bandwidth levels based on guest demand – often by simply placing a phone call.
- Business Hospitality Internet – Offers a range of speeds to address changing needs, including download speeds of up to 100 Mbps and upload speeds of up to 10 Mbps. Additionally, the service equips IT departments with two modems – one for the property's back office and one for hotel guests – so they can better manage network traffic and maintain fast browsing speeds for guests surfing the Web.
- Business Hospitality TV – Provides quality HD video service with up to 60 HD channels. Designed specifically for the hospitality industry, Comcast's HD video services are delivered via a single piece of equipment that enables property managers to remotely manage video feeds – simplifying upkeep and maintenance and providing for better design aesthetics, as set top equipment is no longer required in guest rooms.
- Business Hospitality Voice – Provides hotel properties with full-featured phone lines, including call management and other advanced business functions.
- Business Hospitality Trunks – Connects legacy PBX equipment with Comcast's advanced IP network, enabling hotels and motels – and their guests – to experience next-generation voice services. Property managers can also remain confident that their investments in existing technology will be protected.
For more information on Comcast Business Hospitality, please visit http://business.comcast.com/enterprise/industry-solutions/hospitality.
About Comcast Business Services
Comcast Business Services, a unit of Comcast Cable, provides advanced communication solutions to help organizations of all sizes meet their business objectives. Through a modern, advanced network that is backed by 24/7 technical support, Comcast delivers Business Class Internet, TV and Voice services for cost-effective, simplified communications management.
Launched in 2011, the Comcast Business Class Ethernet suite offers high-performance point-to-point and multi-point Metro Ethernet services with the capacity to deliver cloud computing, software-as-a-service, business continuity/disaster recovery and other bandwidth-intensive applications. Comcast Metro Ethernet services are significantly faster than standard T1 lines and other legacy technologies, providing scalable bandwidth from 1 Mbps up to 10 Gigabits-per-second (Gbps) in more than 20 major US markets.
For more information, call 866-429-3085 or visit http://business.comcast.com/enterprise.
About Comcast Cable
Comcast Cable is the nation's largest video, high-speed Internet and phone provider to residential customers under the XFINITY brand and also provides these services to businesses. Comcast has invested in technology to build an advanced network that delivers among the fastest broadband speeds, and brings customers personalized video, communications and home management offerings. Comcast Corporation (Nasdaq: CMCSA, CMCSK) is a global media and technology company.
Visit www.comcastcorporation.com for more information.
SYS-CON Events announced today that Luxoft Holding, Inc., a leading provider of software development services and innovative IT solutions, has been named "Bronze Sponsor" of SYS-CON's @ThingsExpo, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. Luxoft's software development services consist of core and mission-critical custom software development and support, product engineering and testing, and technology consulting.
Oct. 7, 2015 01:15 AM EDT Reads: 504
Developing software for the Internet of Things (IoT) comes with its own set of challenges. Security, privacy, and unified standards are a few key issues. In addition, each IoT product is comprised of at least three separate application components: the software embedded in the device, the backend big-data service, and the mobile application for the end user's controls. Each component is developed by a different team, using different technologies and practices, and deployed to a different stack/target - this makes the integration of these separate pipelines and the coordination of software upd...
Oct. 7, 2015 12:45 AM EDT Reads: 119
SYS-CON Events announced today that IBM Cloud Data Services has been named "Bronze Sponsor" of SYS-CON's 17th Cloud Expo, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. IBM Cloud Data Services offers a portfolio of integrated, best-of-breed cloud data services for developers focused on mobile computing and analytics use cases.
Oct. 6, 2015 10:00 PM EDT Reads: 656
In his session at @ThingsExpo, Tony Shan, Chief Architect at CTS, will explore the synergy of Big Data and IoT. First he will take a closer look at the Internet of Things and Big Data individually, in terms of what, which, why, where, when, who, how and how much. Then he will explore the relationship between IoT and Big Data. Specifically, he will drill down to how the 4Vs aspects intersect with IoT: Volume, Variety, Velocity and Value. In turn, Tony will analyze how the key components of IoT influence Big Data: Device, Connectivity, Context, and Intelligence. He will dive deep to the matrix...
Oct. 6, 2015 08:00 PM EDT Reads: 311
When it comes to IoT in the enterprise, namely the commercial building and hospitality markets, a benefit not getting the attention it deserves is energy efficiency, and IoT's direct impact on a cleaner, greener environment when installed in smart buildings. Until now clean technology was offered piecemeal and led with point solutions that require significant systems integration to orchestrate and deploy. There didn't exist a 'top down' approach that can manage and monitor the way a Smart Building actually breathes - immediately flagging overheating in a closet or over cooling in unoccupied ho...
Oct. 6, 2015 05:00 PM EDT Reads: 254
SYS-CON Events announced today that Cloud Raxak has been named "Media & Session Sponsor" of SYS-CON's 17th Cloud Expo, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. Raxak Protect automates security compliance across private and public clouds. Using the SaaS tool or managed service, developers can deploy cloud apps quickly, cost-effectively, and without error.
Oct. 6, 2015 04:40 PM EDT Reads: 111
Scott Guthrie's keynote presentation "Journey to the intelligent cloud" is a must view video. This is from AzureCon 2015, September 29, 2015 I have reproduced some screen shots in case you are unable to view this long video for one reason or another. One of the highlights is 3 datacenters coming on line in India.
Oct. 6, 2015 02:00 PM EDT Reads: 231
"The Internet of Things transforms the way organizations leverage machine data and gain insights from it," noted Splunk's CTO Snehal Antani, as Splunk announced accelerated momentum in Industrial Data and the IoT. The trend is driven by Splunk's continued investment in its products and partner ecosystem as well as the creativity of customers and the flexibility to deploy Splunk IoT solutions as software, cloud services or in a hybrid environment. Customers are using Splunk® solutions to collect and correlate data from control systems, sensors, mobile devices and IT systems for a variety of Ind...
Oct. 6, 2015 01:00 PM EDT Reads: 580
SYS-CON Events announced today that ProfitBricks, the provider of painless cloud infrastructure, will exhibit at SYS-CON's 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. ProfitBricks is the IaaS provider that offers a painless cloud experience for all IT users, with no learning curve. ProfitBricks boasts flexible cloud servers and networking, an integrated Data Center Designer tool for visual control over the cloud and the best price/performance value available. ProfitBricks was named one of the coolest Clo...
Oct. 6, 2015 01:00 PM EDT Reads: 741
You have your devices and your data, but what about the rest of your Internet of Things story? Two popular classes of technologies that nicely handle the Big Data analytics for Internet of Things are Apache Hadoop and NoSQL. Hadoop is designed for parallelizing analytical work across many servers and is ideal for the massive data volumes you create with IoT devices. NoSQL databases such as Apache HBase are ideal for storing and retrieving IoT data as "time series data."
Oct. 6, 2015 12:45 PM EDT Reads: 459
Clearly the way forward is to move to cloud be it bare metal, VMs or containers. One aspect of the current public clouds that is slowing this cloud migration is cloud lock-in. Every cloud vendor is trying to make it very difficult to move out once a customer has chosen their cloud. In his session at 17th Cloud Expo, Naveen Nimmu, CEO of Clouber, Inc., will advocate that making the inter-cloud migration as simple as changing airlines would help the entire industry to quickly adopt the cloud without worrying about any lock-in fears. In fact by having standard APIs for IaaS would help PaaS expl...
Oct. 6, 2015 12:30 PM EDT Reads: 586
Organizations already struggle with the simple collection of data resulting from the proliferation of IoT, lacking the right infrastructure to manage it. They can't only rely on the cloud to collect and utilize this data because many applications still require dedicated infrastructure for security, redundancy, performance, etc. In his session at 17th Cloud Expo, Emil Sayegh, CEO of Codero Hosting, will discuss how in order to resolve the inherent issues, companies need to combine dedicated and cloud solutions through hybrid hosting – a sustainable solution for the data required to manage I...
Oct. 6, 2015 12:00 PM EDT Reads: 442
Mobile messaging has been a popular communication channel for more than 20 years. Finnish engineer Matti Makkonen invented the idea for SMS (Short Message Service) in 1984, making his vision a reality on December 3, 1992 by sending the first message ("Happy Christmas") from a PC to a cell phone. Since then, the technology has evolved immensely, from both a technology standpoint, and in our everyday uses for it. Originally used for person-to-person (P2P) communication, i.e., Sally sends a text message to Betty – mobile messaging now offers tremendous value to businesses for customer and empl...
Oct. 6, 2015 10:45 AM EDT Reads: 185
Apps and devices shouldn't stop working when there's limited or no network connectivity. Learn how to bring data stored in a cloud database to the edge of the network (and back again) whenever an Internet connection is available. In his session at 17th Cloud Expo, Bradley Holt, Developer Advocate at IBM Cloud Data Services, will demonstrate techniques for replicating cloud databases with devices in order to build offline-first mobile or Internet of Things (IoT) apps that can provide a better, faster user experience, both offline and online. The focus of this talk will be on IBM Cloudant, Apa...
Oct. 6, 2015 10:45 AM EDT Reads: 453
As more and more data is generated from a variety of connected devices, the need to get insights from this data and predict future behavior and trends is increasingly essential for businesses. Real-time stream processing is needed in a variety of different industries such as Manufacturing, Oil and Gas, Automobile, Finance, Online Retail, Smart Grids, and Healthcare. Azure Stream Analytics is a fully managed distributed stream computation service that provides low latency, scalable processing of streaming data in the cloud with an enterprise grade SLA. It features built-in integration with Azur...
Oct. 6, 2015 10:00 AM EDT Reads: 735
SYS-CON Events announced today that HPM Networks will exhibit at the 17th International Cloud Expo®, which will take place on November 3–5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. For 20 years, HPM Networks has been integrating technology solutions that solve complex business challenges. HPM Networks has designed solutions for both SMB and enterprise customers throughout the San Francisco Bay Area.
Oct. 6, 2015 09:00 AM EDT Reads: 572
The enterprise is being consumerized, and the consumer is being enterprised. Moore's Law does not matter anymore, the future belongs to business virtualization powered by invisible service architecture, powered by hyperscale and hyperconvergence, and facilitated by vertical streaming and horizontal scaling and consolidation. Both buyers and sellers want instant results, and from paperwork to paperless to mindless is the ultimate goal for any seamless transaction. The sweetest sweet spot in innovation is automation. The most painful pain point for any business is the mismatch between supplies a...
Oct. 6, 2015 09:00 AM EDT Reads: 142
The broad selection of hardware, the rapid evolution of operating systems and the time-to-market for mobile apps has been so rapid that new challenges for developers and engineers arise every day. Security, testing, hosting, and other metrics have to be considered through the process. In his session at Big Data Expo, Walter Maguire, Chief Field Technologist, HP Big Data Group, at Hewlett-Packard, will discuss the challenges faced by developers and a composite Big Data applications builder, focusing on how to help solve the problems that developers are continuously battling.
Oct. 6, 2015 04:00 AM EDT Reads: 442
As enterprises capture more and more data of all types – structured, semi-structured, and unstructured – data discovery requirements for business intelligence (BI), Big Data, and predictive analytics initiatives grow more complex. A company's ability to become data-driven and compete on analytics depends on the speed with which it can provision their analytics applications with all relevant information. The task of finding data has traditionally resided with IT, but now organizations increasingly turn towards data source discovery tools to find the right data, in context, for business users, d...
Oct. 5, 2015 08:00 AM EDT Reads: 379
SYS-CON Events announced today that MobiDev, a software development company, will exhibit at the 17th International Cloud Expo®, which will take place November 3-5, 2015, at the Santa Clara Convention Center in Santa Clara, CA. MobiDev is a software development company with representative offices in Atlanta (US), Sheffield (UK) and Würzburg (Germany); and development centers in Ukraine. Since 2009 it has grown from a small group of passionate engineers and business managers to a full-scale mobile software company with over 150 developers, designers, quality assurance engineers, project manage...
Oct. 5, 2015 05:00 AM EDT Reads: 739


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stayed at ola club panama for 10 days arrived on 18 june 2013 the staff were all very polite and helpful we only really ate breakfast at the hotel,there was always plenty of food but to us some very strange combinations that we could not stomach ie- fish with bones in lamb with bones in everything was nicely presented though,the childrens entertainers were excellent and lovely to chat to ,the pool is small and you have to be early to grab a sun bed,our rooms were above the main entrance which was very noisy due to coaches loading and unloading but mainly due to the hotel opposite with youths shouting and swearing urinating of balconies, spitting, girls screaming and this was usually from 7pm to 7am ! it was loud,so if you have children i suggest you get a room away from the front of hotel,rooms were dated but clean and fit for purpose however our room did not get cleaned for two days nor did we have clean towells.we paid 40 euros for air con only to find it came on at 6pm and went off at 2am which was a rip off we also paid a deposit on tv controls 10 euro i think but could only get english news channel on(would of been nice to watch something in english to drown the noise )just around the corner from the hotel is a wonderful little cafe called MARIAS KITCHEN,great food and drink .cheap and clean with wonderful owner and staff who are very kind, i will go back to palma nova but not in this hotel,we had a great time but it could of been better.
- Official Description (provided by the hotel):
- The Ola Club Panama is an All Inclusive hotel, located in Palmanova, not faraway from a beautiful Beach, where you can rest by the sea and play nautical sports..Palmanova is a tourist resort with lots of leisure facilities, like a water park, the dolphins show at Marineland, tennis clubs, go-carting and much more. At night, a wide choice of restaurants, shops, bars and discos let you to enjoy a lively atmosphere ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, Expedia, Travelocity, Hotels.com, Low Cost Holidays, TripOnline SA, Priceline, HotelTravel.com, Orbitz, Odigeo and Agoda so you can book your Ola Club Panama reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.
- Also Known As:
- Ola Club Panama Hotel Palma Nova
- Ola Hotel Palma Nova
- Ola Hotel Panama
- Ola Club Panama Palmanova, Majorca


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- Category: Girls |
- 11 Dec, 2012 |
- Views: 16959 |
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Cleavage pictures of sexy busty girls.
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Our Global Network is dedicated to funding research and health education programmes into the links between food, nutrition, physical activity, body fatness and cancer risk.
Continuous Update Project (CUP)
The WCRF/AICR Continuous Update Project (CUP) is an ongoing review of cancer prevention research that provides up-to-date evidence on how people can reduce their cancer risk through diet and physical activity.
Building on WCRF/AICR's 2007 Second Expert Report, the CUP database is thought to be the biggest database of evidence in the world on how food, nutrition, physical activity and body fatness affect cancer risk.
CUP overview
Find out about the scientific process, our achievements so far and our goals for the future.
Latest findings on ovarian cancer 2014
The latest finding from the CUP on ovarian cancer were published in March 2014.
Cancers currently being updated
Read about progress so far with updating the evidence.
Meet the scientific experts on the CUP Panel. Find out who else is working on the CUP.
Conferences and launches
Find out where WCRF/AICR has/is presenting work on the Continuous Update Project.


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My family (my wife plus two babies of 2 and 15 months) spent last weekend in Salamanca. We wanted a great atmosphere to relax in a beautiful city not far from Madrid (max two hours drive). After some research we found this hotel. It was a great experience. It has a small but more than enough SPA that for 40€ you can book exclusively for your use. In addition the hotel would provide different services as a fisoterapist, a baby sitter for the kids, etc.
The service absolute gentle and nothing was difficult for them. everything served with a smile. Perfect location (5 minutes away from Plaza Mayor, Cathedral or old university) but in a very quite and relax street just in front of a beautiful convent.
the Hotel has only 17/19 rooms. if you can try to book the one in the third floor since it is the only room in the whole floor so the privacy atmosphere will be even greater.
The hotel is placed in a old mannor house, and they have been able to keep all the historical beauty but with the most modern rooms and facilities.
With no doubt a safe recomendation.


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"Glee" took on one of their most ambitious songs to date during last night's Michael Jackson tribute episode: His "Scream" duet with sister Janet!
Star Kevin McHale got to bust out of his wheelchair for a fantasy sequence that was almost a shot-by-shot remake of the notoriously expensive music video.
Playing Janet to McHale's Michael, was Harry -- who, along with Heather Morris, is one of the best dancers the show has to offer.
The result was pretty impressive and definitely one of the best performances of the season.
How do you think they did? Watch the original video below:
© 2015 EHM Productions, Inc. All rights reserved. Reproduction in whole or in part without permission is prohibited.
In partnership with TMZ.com | Privacy Policy | AdChoices


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Chocolate-Dipped Strawberries
This take on the classic fruity treat calls for bittersweet chocolate and pistachios for an added crunch.
Level: Moderate
Serves: 8
Advertisement - Continue Reading Below
- 1 lb. strawberries
- 3 oz. bittersweet dark chocolate
- ¼ c. roasted, shelled pistachios
- Dip strawberries in melted chocolate.
- Place on waxed paper-lined cookie sheet. Sprinkle with chopped pistachios. Refrigerate until set.
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Campus Aerial Photos
Gallery Category:
Honorary Degree Dinner
UNI Day at the Statehouse
Homecoming 2014 President's Club
Team TC/TK and the UNI Hardwoods Project received the 2014 Governor's Volunteer Award
President Ruud meets with our local state legislative delegation.
President Ruud visited the UNI booth at the Iowa State Fair and participated in the Governor's Charity Steer Show.
President Ruud at the 2014 Spring Commencement
On Thursday, Oct. 3, 2013, a community reception was held in honor of President Ruud's installation as UNI's 10th President.


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Richard GrimmettDo you want to write for packt?
Richard Grimmett has more fun working on robotic projects than should be allowed. He also enjoys teaching computer science and electrical engineering at Brigham Young University, Idaho. He has a bachelor's and master's degree in electrical engineering and a PhD in leadership studies. He has written books on how to use Raspberry Pi, Arduino, and BeagleBone Black for robotics projects.
Books from Richard Grimmett
BeagleBone Robotic Projects
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Raspberry Pi Robotic Projects
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Deviant Art
Cinderpelt's PlaceCinderpelt's place among the starsCinderpelt's Place in Fan Fiction More Like This
Two cats sat in an empty clearing. They sat around a once clear pool of water. Now it was clouded with blood and darkness. One of the cats, a pretty tortoiseshell she-cat, crouched beside the pool, her muscles tense.
"I-I can't see anything!!" she cried in frustration.
The other cat, a thick gray furred tomcat, laid his feathery tail on her shoulder. "It's alright, Spottedleaf. I can't either. There are somethings even we cannot foresee. All we know is that the future is clouded and trouble is coming." The tom meowed.
Spottedleaf sighed. "You're right, Featherwhisker. We must just accept what happens." But neither cat would ever expect what did happen.
Starclan members stiffened, some chattering anxiously. One stepped forward to face the water before them. When he looked into the pool, he saw Cinderpaw, an energetic, young apprentice, scampering off to find Tigerclaw, Tunderclan's dark and murderous deputy, at the Thunderpath.
The tom stiffened at
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Manager: Stephen A. Wider
This Band will consist of "Rotating" Musicians including Steve Wider, Bruce Foster, Jimmy Reardon and others.
Mr. Wider is a "Late Blooming" Musician with one recorded song, Ghost Town, which will be officially released soon, after being re-recorded in a State of the Art Studio by a Professiona...See Full Bio


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$4,000 2 bed 2552 E Alameda Avenue, Denver CO, 80209
Previously Listed $4,000 2 bed
2552 E Alameda Avenue, Belcaro, Denver, 80209
Commute to Downtown Englewood
This apartment is in the Belcaro neighborhood in Denver. Nearby parks include City of Karmiel Park, Pulaski Park and City of Brest Park.
2552 E Alameda Avenue has a Walk Score of 43 out of 100. This location is a Car-Dependent neighborhood so most errands require a car.
Come see this impeccably maintained home in the private, gated Cherry Creek Communty of Polo Club North-close to it all! This beautiful ranch home is elegant and spacious! Recently renovated with open floorplan and large, sunny rooms for today's lifestyle -It is perfect. Enjoy sitting on one of 3 outdoor patios and listening to the water. The living room is light and bright with big windows and doors that open up onto a great patio. The dining room has a nice big bay window.
Incredible clubhouse with pool and tennis courts, and fitness room. Located on the bike path across the pedestrian bridge from Cherry Creek Mall.
Pets allowed: No
Most errands require a car.
A few nearby public transportation options.
Flat as a pancake, excellent bike lanes.
Score Details
Explore how far you can travel by car, bus, bike and foot from 2552 E Alameda Avenue.
2552 E Alameda Avenue has some transit which means a few nearby public transportation options. Car sharing is available from RelayRides.
Bus lines:
3 Alameda Avenue
0.4 mi
24 University Blvd
0.4 mi
46 South Dahlia
0.4 mi
83L Cherry Creek / Parker Rd Limited
0.4 mi
3L East Alameda Limited
0.4 mi
79L Cherry Creek / Dayton Limited
0.4 mi
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2552 E Alameda Avenue is in the Belcaro neighborhood. Belcaro is the 26th most walkable neighborhood in Denver with a neighborhood Walk Score of 63.
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Save the Children's Health and Nutrition programs seeks to facilitate and promote sustained improvements in health status, with special attention given to the needs of women and children, and especially poor and marginalized populations. As such, we seek to share and communicate about our research and program activities. Key publications are listed alphabetically below by technical area, and are available to download.
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College News
Fisher Football Marches on in NCAAs in Texas
Nationally-ranked St. John Fisher College advanced to the quarterfinals of the NCAA Division III Football Championship with a convincing 27-6 win at previously unbeaten Hobart College on Saturday.
With the win, Fisher improves to 10-2 overall, marking the fifth time in the last 10 years the Cardinals have reached double-digits in the win column. It is the fourth consecutive time Fisher has advanced to the Elite 8 (2006, 2007, and 2011) in NCAA action. The victory also marks the second consecutive week Fisher has knocked off a top 10 team. Fisher, ranked 25th in the final regular season D3football.com poll, beat No. 8 Hobart this week after rallying last week from a 13-0 deficit to win 25-16 at No. 9 John Carroll University.
Fisher will travel to Belton, Texas, to face the No. 3 Mary Hardin-Baylor Crusaders (12-0) in the NCAA Division III Football Championship quarterfinals. Kickoff is scheduled for Saturday, December 7, at 12 p.m. CST (1 p.m. EST).
Check out photos from Fisher's 2015 Move In Day on Flickr!
Latest College News Stories
- Communication Professors Earn Awards at National Conference
- Swiencicki Published in Women's Studies in Communication Journal
- Fisher Communications/Journalism Alum Given Courage in Journalism Award
- Seven Presidents, 60 Years. Dr. Don Muench Reflects on Fisher's Fearless Leaders
- Journalism Students Work with Local News Station to Cover Rochester's Hidden Gems
- Nursing Students Spend Summer in Internships Learning Patient Care and More
- Oral History Project Shares Memories, Reflections from Pioneer Class
- Service Trips Defining Experience for Pharmacy Students
- October First Friday Lecture Explores Evolving Nature of Science Education
- Center for Youth Honors Fisher's Rick DeJesús-Rueff
- Optics and Extraterrestrials the Focus of Oct. 13 Loss Lecture
- Fisher Wins Courage Bowl XI in Double Overtime
- Grant Funds Substance Abuse Screening and Intervention Training for Pharmacy, Nursing, and Mental Health Counseling Students
- Martin Mucci Named Inaugural Influential Leader from AACSB
- Dialogues Explore Issues of Race, Equity, and Justice


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Press release
For the first time in the Netherlands: Six panels by Pieter Bruegel the Elder together
2 October 2015
Five panels by Pieter Bruegel the Elder are travelling to Museum Boijmans Van Beuningen from all over the world for 'Uncovering Everyday Life – From Bosch to Bruegel'. Visitors to the exhibition will have the unique opportunity to see six panels by this sixteenth-century old master together in Rotterdam. Never before have so many Bruegels been gathered together. 'The Pig Must Go in the Sty' (1557), owned by a private collector, makes its first ever appearance in an exhibition.
The oeuvre of Pieter Bruegel the Elder (c. 1526 -1569) is small (around forty works) and his works are fragile, so museums are understandably cautious about lending these panels. In a single exhibition in Rotterdam, Museum Boijmans Van Beuningen is showing 'The Peasant and the Birdnester' from Vienna, 'Winter Landscape with Bird Trap' from Brussels, 'Three Soldiers' from New York, 'The Crippled Beggars' from Paris and 'The Pig Must Go in the Sty' from a private collection. Bruegel's 'The Tower of Babel' of 1560, possibly the artist's most iconic painting, can be seen elsewhere in the museum, in the permanent collection.
Pieter Bruegel the Elder: the Great Exemplar
Subjects painted by Pieter Bruegel the Elder, who lived in the Southern Netherlands, were frequently copied by later painters. Bruegel's oldest work in the exhibition is 'The Pig Must Go in the Sty'. This panel, based on a medieval saying, shows a group of people pushing a man into a pigsty. It is painted on the back of a trencher – a wooden plate – and is consequently round. 'The Peasant and the Birdnester' is a work Bruegel the Elder made later in his career and has all his famous characteristics: the subtle painting technique and the peasant themes. 'Winter Landscape with Bird Trap' is an atmospheric scene with skaters thronging the ice, a theme for which the painter is world-renowned. We know of at least 120 seventeenth-century copies of this work. To this day the image can be found on a wide range of items.
Pioneers of Everyday Life
Pieter Bruegel the Elder's world-famous paintings are the finale to the work of three generations of artists who started a veritable revolution in painting in the sixteenth century. In the early part of that century Jheronimus Bosch was one of the first to begin painting everyday life. Following in his footsteps, other artists like Lucas van Leyden, Quinten Massys and, above all, Pieter Bruegel the Elder, also discovered daily life. In the autumn exhibition 'Uncovering Everyday Life –From Bosch to Bruegel' (10 October 2015-17 January 2016) Museum Boijmans Van Beuningen presents a selection of top-flight paintings and prints. These are works of art that mirror society with irony and self-mockery and have no truck with prudishness: from brothels to crowds of skaters, from unrequited love to merry-making peasants. Sometimes there is a moral, but the humour, the malicious delight and the self-mockery always predominate. With forty paintings and as many prints by such artists as Jeronimus Bosch, Lucas van Leyden and Quinten Massys, Jan Sanders van Hemessen, Marinus van Reymerswaele, Jan Provoost, Pieter Aertsen and Joachim Beuckelaer and Pieter Bruegel the Elder.
For more information or/ and images, please contact the Marketing and Communication Department
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You cannot help but notice the tufting on the Cleveland Leather Executive Side Chair, but don''t stop there, notice the tapered legs in Old World Finish and the Decorative nailhead trim that adorns the gentle curves and scallop style front rail. Double-doweled joints are cornering blocked, glued and screw supported to create a solid frame for this side chair. Quality hand-crafted leather furniture at affordable prices is the mantra behind the Seven Seas Seating name.
Product Details
Upholstered Seat
Upholstered Back
Weights & Dimensions
|Product Type: Lounge chairs
|Style: Traditional
|Seating Capacity: 1
|Arms Included: Yes
Upholstered Seat: Yes
Upholstered Back: Yes
|Finish: Brown
|Frame Material: Wood
|Seat Material: Leather
|Back Material: Leather
|Number of Items Included: 1
|Solid Wood Construction: Yes
|Floor Glides: Yes
|Stackable: No
|Waterfall Seat Edge: Yes
|Connected Table: No
|Product Care: Wipe clean with a dry cloth
|Country of Manufacture: China
|Assembly Required: Yes
|Additional Parts Required: No
About the ManufacturerSeven Seas Seating was developed by one of America's premier manufacturers, Bradington-Young. Quality hand-crafted leather furniture at affordable prices is the mantra behind the Seven Seas Seating name.
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When I taught Aikido it was very common to see students struggle through learning a technique. Instead of just doing the exercise, it was obvious that they were thinking a lot about how and why it did or didn't work. They had 'analysis paralysis'. They were so busy thinking about the 'how' that they missed the 'doing'.
There is a Buddhist story about a man shot with an arrow. The gist of the story is that it doesn't do any good to think about who shot the arrow, what bird did the feathers come from, what type of tree is the shaft made from, etc. All of that doesn't help the patient with his problem of having an arrow sticking out of him. That is the #1 problem that needs to be addressed immediately. We need to remove the arrow as quickly and safely as possible.
My Tai Chi teacher used this story the other day to illustrate why his students had such a hard time learning the art. "When I tell you to relax, instead of just relaxing, you think of how and why should you relax. You are looking at the feathers on the arrow & thinking about their color and the bird they came from. It isn't that complex, just use less."
Depression is a big arrow.
Walking the black dog you soon discover that it's easier to think about life than experience it. Thinking or ruminating gives us the illusion of control. Like my worrying about my son and his passing his barber's exam a couple of months ago. All my worrying did was keep me from living the moment to the fullest. Instead of experiencing a right of passage with my son, I was consumed by thoughts that it was going to fall apart and he wouldn't get his license and so would lose his job. If he lost his job then my stress would go up as I feel responsible to help him emotionally and financially, etc. etc. I was looking the feathers on the arrow. It's a domino effect. Before you know it all of your emotional dominoes are falling over.
So how do we stop the thought train and experience life? For me it's by practicing mindfulness. I practice formally at least 5 times a week. Usually over the lunch hour instead of eating, I sit and watch my breathing, observe my thoughts and just listen and watch without making any judgments. If a car goes by I don't think about what kind of car it is or where the driver is going, I practice just hearing it without adding a lot of thoughts to it. Of course my mind does wonder and before I know it I am daydreaming about who's in the car and why don't they slow down, etc. but even that is an opportunity to practice. When I notice my mind doing that, I let it go and go back to my breath, to just listening and just seeing, just being. Accepting things as they are.
My mind isn't exactly clear, but I am working on it. From the classes on Buddhism that I took they talk about learning to let go of always attaching thought to things. One of their sayings is that when your mind is clear it's like a mirror. When red comes, only red. When white comes only white. A dog barks, "woof, woof." There's no thought of I like red but not white - or they should let that dog in, it's too noisy!
One of the teachers there related a nice little story about how one night years earlier after practicing meditation he was walking to his car to go home when he saw an orange VW parked on the street. Between the moonlight and streetlight hitting it he said it just hit him with its 'orangeness'. There was no thought about how bright or brilliant it was - or that it was a cool car. For him it was a direct experience of ' ORANGE ' - nothing else. Shortly after that experience he came back to his thinking mind and try as he might, he couldn't grab that experience again no matter how hard he tried.
You can't make it happen. You can only set the stage to allow it to come. Water will settle down on its own when you stop stirring it up!
For me it's an excellent addition to the TLC program and it's proven it's effectiveness is taming the black dog.
Depression Treatment: Mindfulness-based Cognitive Therapy As Effective As Anti-depressant Medication, Study Suggests
Be sure and check out the many links to related stories. There's a lot of good news about treating depression.
Also check out my earlier posts -


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News Archives
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August 10, 2015
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System of a Down Perform 'Toxicity' With Deftones' Chino Moreno at Rock in Rio
During the band's near two-hour set, System invited Deftones frontman Chino Moreno onstage to help sing "Toxicity."
During the band's near two-hour set, System invited Deftones frontman Chino Moreno onstage to help sing "Toxicity."
"Embers" is certain to be a fan favorite from 'VII: Sturm und Drang.'
The Alice in Chains guitarist will lend his talents to a song on the upcoming Deftones disc.
Deftones have been working on a new album, and now more details are being revealed about when it will likely be released.
One year ago today (April 13), Deftones said goodbye to bassist Chi Cheng, who passed away after a 2008 car accident left him mostly in a coma for four and a half years. On the one year anniversary of his passing, frontman Chino Moreno has posted the unreleased song 'Smile' from Deftones' shelved album 'Eros.'
Deftones frontman Chino Moreno may be spending his time in Australia promoting his other band Crosses, but that doesn't mean that Deftones are taking things easy. Despite an earlier report that the band would be taking the year off, it's all systems go in the Deftones camp.
The release date for ††† (Crosses) self-titled debut album is tomorrow (Feb. 11), and you can listen to a full stream of the album via Pitchfork. In a new interview, ††† vocalist Chino Moreno talked about the status of Deftones, and also about the loss of his bandmate Chi Cheng.
The self-titled debut album of ††† (Crosses) will be released Feb. 11, and the band has just unleashed the video for the single 'Bitches Brew' (watch above via Rolling Stone). The group is made up of Chino Moreno (Deftones), Shaun Lopez (Far) and Chuck Doom.
Chino Moreno may be going strong with Deftones, but this summer fans will be treated to his more atmospheric and moody side as he rocks out with his friends from Isis in the new band Palms. The group's self-titled debut is due June 25 via Ipecac Recordings and the album artwork and track listing for the effort have now surfaced.
The Dillinger Escape Plan played a hard-hitting set at the 2013 Revolver Golden Gods last night (May 2), with frontman Greg Puciato bleeding profusely from his forehead during the performance...
Chino Moreno has more than Deftones on his plate these days, and fans are now getting a chance to check out some music from his side group Palms. Moreno was recruited to sing on the album by three of the former members of Isis, who are also part of the group. Now the first song 'Patagonia,' from their self-titled effort has surfaced online.
Deftones frontman Chino Moreno is a man of many projects and his latest finds him recording with several former members of the band Isis in a new group called Palms. The band has confirmed the completion of their self-titled debut album and the disc is now due June 25 through Ipecac Recordings.


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Duty Rescue
Greate action shooting game!!Duty Rescue is a challenging and interesting run-and-gun game. The commando has the calling to rescue the hostage. The rescue way is difficult. At last, there is a mystical boss waiting for you...As for hostage, the comming back of commando means rescue is at hand.For challenge, this is for you...FEATURES:Various weapons: pistol, submachine gun, grenadeChallenging movements: jump, run, topple overDifferent direction shoot, jump, run, and topple over shootVarious enemies: grenadier, bombardier, mine, tank, parachuter, mystical boss Luxuriant scenes, sounds and musicsWe hope you have as much fun playing Duty Rescue as we did making it!!!