text:
Rachel Made her first event of 2015 on 26th June, 2015 for the The 41st Annual Saturn Awards in Burbank. Both her self and Continuum were up for awards that night but miss out on them in the end. You can check out 30 medium and high quality photos of Rachel walking the red carpet and backstage at the award show.
– Public Events > 2015 > The 41st Annual Saturn Awards
Rachel Nichols, star of Showcase's hit science-fiction TV drama series "Continuum," recently opened up as to why Vancouver's "other worldly, futuristic feel" is the perfect location to film the scripted program.
Nichols said the coastal Canadian city has played an integral role that the coastal Canadian city in the creation of the series.
"The city — the aesthetic, the architecture, all the glass, all the windows — especially at night, but even during the day — it has this otherworldly futuristic feel," the actress, who plays time-traveller Kiera Cameron, told The Province. "I mean, Vancouver is one of the most beautiful cities in the world and I've lived in many of them so I feel like I can say that and speak the absolute truth."
Nichols went on to say that having the setting filmed at Vancouver actually saves the "Continuum" a lot of effort when they needed to shoot for the show's cityscape.
"There is this quality about it that feels though as if it is from the future so a lot of what we do on Continuum or other shows that have to have a futuristic element, if you can take what downtown Vancouver looks like and you can elaborate it a little bit or add certain things to it, but you don't have to create an entirely new city in CG," she said.
Earlier reports cited Nichols giving her thanks to the TV network for giving her the opportunity to finish the show "with a riveting conclusion that the series truly deserves." The actress added that the final season is primarily dedicated to the devoted fans of "Continuum."
"Continuum" Season 4 is slated to premiere on Sunday, July 25 on Showcase.
Credit: christianpost.com
I've just added in DVD screen captures from Rachel's 2009 movie performance in 'For Sale By Owners', Rachel dose not do a lot in this but dose pop up a lot in it as the girlfriend who thinks her boyfriend is going crazy most of the time, I have added caps from the movie just a shame there were no bonus features on the dvd, view them in the gallery.
– Movie Productions > For Sale By Owners > DVD Screen Captures: Movie
I have added in some new candids of Rachel from I would guess one of the last episodes of Continuum to be filmed. As well as some BTS photos that have been taken by the cast and fans over the filming of the last season. Enjoy.
– Television Series > Continuum (2012-2015) > Season 4 > On Set > April 21th, 2015
– Television Series > Continuum (2012-2015) > Season 4 > On Set > Other Candids


text:
4474FW: Service For Peace Update Jan 16th.
Expand Messages
- Jan 17, 2014
Date: Thu, 16 Jan 2014 15:25:33 -0500
From: pastor@...
To: oaringeagle59us@...
CC: stinger1959@...
Subject: Fwd: Service For Peace Update
I hope Everyone Had A Very Merry Christmas & a Happy New Year! Great Thanks to Everyone for Your continued Support!
This Monday Jan 20th is the DR. Martin Luther King, JR. National Day of Service. Info follows:WAVE 3 news link follows:http://www.wave3.com/story/24456888/overhaul-begins-at-vandalized-shawnee-church-as-service-for-peace-projectMany of you may not know - Many years ago, In Louisville, SFP created the DR. MLK JR., "Season of Service". It goes from the national holiday in honor of DR. King's birthday to the anniversary date of the assassination of DR. King April 4th. Here is the razoo link for anyone who wants to help us get funds in for the 11th Annual DR. Martin Luther King, JR. Day of Service, this Monday Jan 20th - April 4th (SOS). http://www.razoo.com/story/Annual-Dr-Martin-Luther-King-Jr-Season-Of-Service You may also mail a check to Service For Peace, PO Box 17006, Lou. KY 40217.This year as usual, we have many volunteer service projects going on this DR. MLK JR. Day, Monday Jan. 20th. The slogan is, "Make it a Day On not a Day Off". It is all about embracing the life, legacy, and honoring Dr. King through service. Coretta Scott King stated some many years ago, before she passed away, "the very best way to honor DR. MLK, JR. was through service". This year our marquis event is at the Liberty Bible Baptist Church. We need resources, and volunteers on MLK Day (this Monday) and through the Season of Service ending April 4th. See the WAVE 3 news link above to see the story on the Liberty Bible Baptist Church in the Shawnee neighborhood. Check out the razoo link above for more info on the 11th Annual DR. Martin Luther King, JR. National Day of Service. SFP is the lead agency nationally with the National Corporation for Community Service. The NCCS is in charge of the DR. MLK, JR. "DOS" and the 9/11 National Day of Service & Remembrance. These are the only two National Days of Service. NCCS is funded & overseen by Congress.UAW/FORD Local 862 has come to the rescue once again - this time by honoring the life, & legacy of DR. King, by serving the people in the Shawnee neighborhood, just check out the WAVE 3 news link above. U of L will have 25 students also volunteering at the LBBC on MLK Day. Please post, e-mail blast, and get this info out to any & all!Always Great THANKS to Everyone for Your Support & for All the Great Things You ALL do for our Community!
Always Pray for our Servicemen, Servicewomen, ALL First Responders, their Children & Families!
In Service Always,
Michael Morgan
Operation Helping Heroes
Christmas Angel Benefiting the Children & Families of our Military Heroes9/11 National Day of Service & Remembrance
Programs DirectorService For Peace

subset: commoncrawl


text:
Change Location
ACE Fit Share
Build up your biceps and triceps with these simple arm exercises from the American Council on Exercise. Learn valuable how-to information and get expert fitness advice that will help you strengthen your arm muscle groups including the biceps, triceps and wrists. We have a wide variety of arm strenghtening exercises from the beginner to advanced level including the dumbbell bench press, triceps kick-backs, bicep curls and more. For full workout routines that feature arm exercises, check out our Workouts section.
Fit Life Articles
If you have aches and pains, or just feel sore after your workouts, you should consider trying a technique called self-myofascial release (SMR). Often performed with a foam roller, SMR is a great way to help alleviate the pain of "trigger points," while also increasing...
Strong, toned triceps muscles are a goal for many people—men and women alike. This 10-minute triceps workout, which involves extending the elbows against resistance, will not only help create toned muscles, but also build the strength needed for everyday activities...
Strong biceps are not just for show—they are responsible for bending the elbow and make it possible for you to lift and carry heavy objects—including your own body weight. This 10-minute biceps workout is a great way to strengthen these essential muscles.


text:
Expert Comment
Blatters Long Goodbye dredges up the sheer scale of corruption that is killing football - Dr David Webber
"Fifa's Ethics Committee yesterday (7 October) requested that Sepp Blatter and his would-be successor Michel Platini be suspended. In what could be a significant turning point in the reform of football's governing body, this intervention nevertheless reveals the sheer scale of corruption in world football," says Dr David Webber, a lecturer in the cultural political economy of sport at the University of Warwick.
Is Theresa May a threat to a cohesive society? - Dr Hannah Jones
"Theresa May, the Home Secretary, says that "cohesion" is "impossible" with high levels of migration. This is factually wrong. This kind of statement is itself a threat to a peaceful society in which everyone can live safely and well," writes Dr Hannah Jones from the University of Warwick.
The Trans-Pacific Partnership a trade deal with a major global implications - Dr Dennis Novy
Dr Dennis Novy, an economist from the University of Warwick and a former House of Lords adviser on the Transatlantic Trade and Investment Partnership, offers reaction to the new Trans-Pacific Partnership that was agreed on Monday.
Why does the gun lobby claim arms ownership is a social good?
Deborah Lynn Steinberg, Professor of Gender, Culture and Media, views the recent US mass shooting from an American ex-pat point of view.
The 1790s right to bear arms has been twisted to defend gun ownership
Dr Tim Lockley provides a historical perspective on the latest US mass shooting discussing how the right to bear arms from the 1790s has been twisted into defending modern day gun ownership.
Older news
Show selected
Select all / none


text:
to the Tompkins County Climate Protection Initiative
309 North Aurora Street | Ithaca, NY 14850 | 607-229-6183 | email@example.com
TCCPI is an award-winning climate action and clean energy coalition in the Ithaca, NY area made up of community leaders from the education, business, local government, nonprofit, and youth sectors.
Taitem Engineering and Learn@EcoVillage will be holding a training on September 28-29, co-sponsored by the U.S. Green Building Council Upstate NY chapter. This net-zero workshop will be very useful for architects, green builders, engineers, and community developers. Read more...
NYSEG's refrigerator and freezer recycling program offers the company's residential electricity customers a $50 check for recycling an old, working refrigerator or freezer. Getting rid of that energy hog can save up to $150 a year in electricity costs. Read more...
Friday, October 30, 2015
9:00 - 11:00 am
Tompkins County Chamber of Commerce
904 E Shore Dr.
Ithaca, NY 14850


text:
PlaneShift is a Free Massively Multiplayer Online Role Playing Game. Free?
EVE Online is a massive multiplayer online game that offers limitless potential to discover, explore and conquer an amazing science fiction universe where you pilot spaceships, fight, trade, and form...
The Lord of the Rings Online™ (LOTRO) is the first MMORPG set in the world of J.R.R. Tolkien's The Lord of the Rings. LOTRO takes place in a persistent online world and is free-to-play
Awesome fantasy MMORPG 2D pixel shooter with a focus on co-op combat! Try to defeat the mad god Oryx, gain levels and max stats!
Stendhal is a fun friendly and completely free 2D multiplayer online adventure game with an old school feel.
Eternal Lands (EL) is a free, multiplayer, online role-playing game (MMORPG) created by Radu Privantu in 2002. The setting is a medieval fantasy world. There are historic elements such as medieval architecture...
[NOTE: The game is still in production and we have no estimated release date yet.] Legends of Equestria is a massively multi-player online game based on the television show My Little Pony: Friendship is...
Evol Online is a massively multiplayer online role-playing game using source forked from The Mana World. The games' interface is so closely related that players can use the same client to log into either.
Daimonin is a community driven open source MMORPG.
Auteria is an MMORPG with a fantasy setting. Explore different areas, fight, and increase skills such as harvesting and smithing.
Did you find any errors in the info about PlaneShift? Maybe you know an awesome alternative that's not already listed? You can edit the info about PlaneShift and suggest new alternatives to it below.


text:
Caroline Manzo Absolutely Berates Danielle Staub in Court Deposition
Caroline Manzo hates Danielle Staub. Don't we all.
Until now, we've never heard her explain how she feels in this kind of detail, however. In a recent court deposition for Staub's legal war with her ex-husband Kevin Maher, her Real Housewives co-star Caroline tore her a new one.


text:
Saint Laurent
Flared Jeans
Product Actions
Saint Laurent blue cotton denim flared-leg jeans.
- Two patch pockets at front and back
- Goldtone snake-chain locker loop at interior waist
- 8.5" rise, 33.5" inseam, 17" leg opening, approximately
- Zip fly with button fastener
- Available in Blue
- Cotton
- Dry clean
- Made in Italy
Style # 503707083
Our model is 5'10"/178cm and is wearing a size 26.
Since taking the reins at the iconic French fashion house in 2012, designer Hedi Slimane has set about transforming Saint Laurent into a constantly buzzed-about source of rock star-worthy offerings for men and women.
Need Help? Have Questions? Contact Us.
Please call 1.888.222.7639 to speak with a Customer Service Representative.
We're here to help you:
Monday - Friday, 9 AM - 9 PM (ET)
Saturday - Sunday, 11:30 AM - 8 PM (ET)
If you prefer email, we can be reached anytime at firstname.lastname@example.com.
Complimentary Shipping & Returns on all U.S. Orders. See Details.


text:
In the News
October 3, 2015
Controversial reporter returns to television
Investigative reporter Sharyl Attkisson is taking on a new TV challenge after leaving her two-...
October 2, 2015
WATCH LIVE: Obama holds press conference
Obama is set to announce the resignation of Education Secretary Arne Duncan.
October 2, 2015
Trump stays on top of GOP field in Pew poll
The real estate mogul garners 25 percent support, followed by Ben Carson at 16 percent.
October 2, 2015
Ryan to Transportation committee: Move forward on highway bill without us
Ryan's push for a big infrastructure tax deal may fall flat before the Oct. 29 funding deadline.
October 2, 2015
Republicans slam Obama's 'rant' on guns
"Mr. President, please no more speeches," Former Rep. Allen West said.
October 2, 2015
Bush-Rubio rivalry breaks out
The long-simmering rivalry between the candidates has spilled out into the open.
October 1, 2015
Obama: Mass shootings are 'something we should politicize'
"This is a political choice that we make, to allow this to happen," he said.
October 1, 2015
Weighing the 'Melania factor' for Trump's campaign
The Hill's Judy Kurtz joins Fox 5 for her weekly In The Know segment.
October 1, 2015
Carson on how to prepare for Hurricane Joaquin: I don't know
The GOP presidential candidate said he doesn't know what precautions he would take if he were...
October 1, 2015
White House calls for tougher gun laws in wake of Oregon shooting
Taking "sensible steps" on guns "continues to be a top priority," press secretary Josh Earnest said.


text:
An NFL team in desperate need of quarterback help contacted Brett Favre this week. And no, it wasn't the Texans.
According to ESPN's Adam Schefter, the St. Louis Rams called Favre's agent, Bus Cook, to see if his famous 44-year-old client would be willing to make another comeback.
Favre, who wasn't played since the 2010 season, said in a radio interview this morning that he's officially retired and has no interest in returning to the league.
"It's flattering, but you know there's no way I'm going to that," he said.
"I had a great career. I think if anything, the last year that I played was an obvious writing on the walk, vision for you if you will," Favre said. "It was time."
The Rams are in search of a signal-caller after starter Sam Bradford suffered a torn ACL in his left knee in Sunday's loss to Carolina. Bradford will miss the rest of the season.
Kellen Clemens was the only other quarterback on the Rams' roster until the team signed Brady Quinn and Austin Davis on Tuesday.
- gallery_thumbnails_photo|ultimatetexans-2348-post-44597-g16913|ultimatetexans-2348-post-44597-g16913|1
- gallery_thumbnails_photo|ultimatetexans-2348-post-44597-g16913|ultimatetexans-2348-post-44597-g16913|2
- gallery_thumbnails_photo|ultimatetexans-2348-post-44597-g16913|ultimatetexans-2348-post-44597-g16913|3
- gallery_thumbnails_photo|ultimatetexans-2348-post-44597-g16913|ultimatetexans-2348-post-44597-g16913|4
- gallery_thumbnails_photo|ultimatetexans-2348-post-44597-g16913|ultimatetexans-2348-post-44597-g16913|5
- gallery_thumbnails_photo|ultimatetexans-2348-post-44597-g16913|ultimatetexans-2348-post-44597-g16913|6
- gallery_thumbnails_photo|ultimatetexans-2348-post-44597-g16913|ultimatetexans-2348-post-44597-g16913|7
- gallery_thumbnails_photo|ultimatetexans-2348-post-44597-g16913|ultimatetexans-2348-post-44597-g16913|8
- gallery_thumbnails_photo|ultimatetexans-2348-post-44597-g16913|ultimatetexans-2348-post-44597-g16913|9
- gallery_thumbnails_photo|ultimatetexans-2348-post-44597-g16913|ultimatetexans-2348-post-44597-g16913|10
- gallery_thumbnails_photo|ultimatetexans-2348-post-44597-g16913|ultimatetexans-2348-post-44597-g16913|11


text:
Narrow your search
Apple says "serious" gamers will be able to use Apple-certified MFi game controllers with the new Apple TV.
The Internet has become an infinitely more exciting place since The Webby Awards started back in 1997. It is now a place where short films can be used to spark global conversations.
When bidding on detritus you'd probably walk past at a flea market, it's not the condition of the item that counts, it's where it's been.
Friends or family owe you money? Here are some cash-free ways to get paid back.
Need help from HP? Or Dell? Or just about any other computer or device maker? Don't fall into this trap.
The comprehensive new iOS app teaches you to pronounce and converse in the fictional language, spoken by the nomadic Dothraki people.
A Utah social media specialist says a Language Center believed that writing about words that sound the same but are spelled differently associated the school with a gay agenda.
The linguist behind the language of the wild horsemen in "Game of Thrones" previews his forthcoming Dothraki primer at San Diego Comic-Con -- and offers some language lessons.
As demonstrated by the ailments that plague ISS astronauts returning to Earth, we're simply not built for space. What would happen to a human fired out of an airlock?
An upcoming short film called Construct finds new ways to use the current CG animation technology to produce mind-blowing results.


text:
Advanced Water Treatment Companies in Honduras
Category: Water & Wastewater ×
Subcategory: Advanced Water Treatment ×
Location: Latin America ×
Location: Honduras ×
Fluxana GmbH Co. KG
based in Bedburg-Hau, GERMANY
We are dedicated to serve and support the x-ray fluorescence (XRF) spectroscopist. We supply users of XRF a wide selection of accessories such as sample cups, sample support films, chemicals and certified reference materials. Furthermore we offer a spectrum of different XRF sample preparation machines like fusion machines VULCAN,mills and presses VANEOX. We provide a full ...
Polypipe Civils
based in Doncaster, UNITED KINGDOM
We design, develop and manufacture the widest range of plastic piping products, with over 20,000 product lines available.Our primary focus is on developing and supporting pragmatic product systems through specific knowledge and understanding of the residential, commercial, civils and infrastructure market sectors. We ensure that customers can trust our unrivalled ...
Prozone International
based in Huntsville, ALABAMA (USA)
Prozone Water Products is a manufacturer of ozone generators for air and water purification systems for residential, commercial and industrial use. Prozone is a world leader in ozone generator manufacturing and ozone applications engineering. Ozone`s patented germicidal UV combined with ozone creates Advanced Oxidation processing, a purification technology that is ...
SnowPure Water Technologies
based in San Clemente, CALIFORNIA (USA)
SnowPure Water Technologies manufactures and supplies an array of water purification and process components directly to system integrators in 55 countries. Our technologies include: Electrodeionization (EDI), Power Supplies, Nanofiltration (NF), Ultrafiltration (UF), Reverse Osmosis (RO), Ion-Exchange Membranes, Electrodialysis (ED), Ultraviolet (UV), and Gas-Transfer ...
Agape Water Solutions, Inc.
based in Harleysville, PENNSYLVANIA (USA)
Agape Water Solutions, Inc. provides industrial water treatment equipment and technical support services. We have unsurpassed knowledge and experience with membrane systems including reverse osmosis (RO), electrodeionization (EDI) and microfiltration (MF) / ultrafiltration (UF).
QUA Group LLC
based in Canonsburg, PENNSYLVANIA (USA)
QUA® is an innovator of advanced membrane technologies that address the most demanding water challenges. Headquartered in the USA, QUA's products enable its OEM partners to provide cutting-edge solutions to end users in industrial and infrastructure markets worldwide. The company's diverse product portfolio includes FEDI® (fractional electrodeionization), Q-SEP® (hollow ...
Dow Water & Process Solutions
based in Midland, MICHIGAN (USA)
Dow Water & Process Solutions (DW&PS) offerings are used throughout the world to improve the quality of drinking water and the water that`s critical to essential industrial processes like chemical processing, power generation and the manufacturing of food and pharmaceuticals. Dow technology is also vital to desalination and water reclamation efforts in communities with ...
OPCO Laboratory, Inc.
based in Fitchburg, MASSACHUSETTS (USA)
OPCO Laboratory, Inc. manufacturer, for your most demanding optical requirements. We manufacture custom lenses, mirrors, gratings and optical assemblies for spectroscopy markets worldwide. Our state-of-the-art optical manufacturing, metallic and dielectric coating, optical replication, electro-optical assembly, QC, and class 1000 clean room facilities, guarantee the ...
AnoxKaldnes AB - a Veolia Water Company
based in Lund, SWEDEN
Supplier of the innovative Moving Bed Biofilm Reactor (MBBR) used for the treatment of water and wastewater. Provide biological wastewater treatment systems with the capability of increasing a BOD plant to complete nitrification by adding only media, retaining screens and additional air to the existing system. Our solutions and especially those based on Moving Bed ...
LIT UV EUROPE / LIT Technology
based in Moscow, RUSSIA
LIT is a leading manufacturer of ultraviolet disinfection equipment. For more than 15 years we have been involved in the design, development, production and installation of UV-systems and –projects. The capacities of our UV-systems range from a few cubic meters per hour up to unparalleled volumes of more than 1.000.000 m³ /day. We are among the top three manufacturers of ...


text:
D.R.C. Jun 26, 2013 11:02 AM
Re: Contacts error every 30 seconds: "IMAP factory connection failed" in response to D.R.C.
OP here with some additional information regarding this ongoing problem.
I realized that by default, the Alerts service was configured to send out e-mails notifying of various problems (disk unreachable, disk space, virus detected, etc). I unchecked all the boxes for E-mail notification, and for good measure, erased the Recipient e-mail address that appears on the Alerts screen. Alas, this made no difference. The same "IMAP factory connection failed" error is still getting generated every 30 seconds.
Perhaps an undocumented required for ML Server is that the Mail service has to be activated?? If so, why would Apple provide an ON/OFF switch for the Mail service? There must be some way to disable ML Server from attempting to make an IMAP connection.


text:
Switch - old sound equipment.
Ecole Olivier Métra, Paris. Field recordings made within the school grounds. A pen lid is taken on and off.
A bit of plaster falling from wall.
hotel key card into door and door opened. recorded on HDR with Sennheiser shotgun mic
Switch - old sound equipment.
Recordings made in the frame of The City Rings project February 2014. Sounds from objects that are beloved to the ...
Door handle turning, 3 mics: 3000B, SM57, SM58
Foley SFX produced by my me and the other members of my foley class for the jungle car chase segment ...
Icicles being dropped.
A wooden door with a lock opening and closing, with
a door, opening and closing
Clip featuring a Mercedes-Benz 190E-16V driver's door being opened and closed. Recorded with a Rode NT1a in the passenger seat, ...
This sample is part of a set of processed and game ready recordings of a Bundeswehr bag filled with different ...
a wooden door closing
squeaky rub of a balloon


text: Thanks to Pippa and Ian for the flexibility to stay at this cottage. I stayed 3 of 5 nights at the cottage and was able to store my excess baggage while hiking the tracks. Pick up and drop off from ferry. Very clean and modern with all the details of a well thought out rental property. Nice kitchen, laundry and... More


text:
by Michael Bourne
Special Section
Posted 6.17.15
Agent Renée Zuckerbrot recounts her initial reactions to the opening story of Andrew Malan Milward's I Was a Revolutionary, a collection she recently sold to Harper that will be published in August.
by Reagan Upshaw
The Literary Life
Posted 4.15.15
The assistant poetry editor of Able Muse offers his thoughts on coming to terms with the inevitability—and impersonality—of rejection in the world of literary magazines.
by Michael Taeckens
The Practical Writer
Posted 1.15.15
January/February 2015
In the inaugural installment of our new feature, Reviewers & Critics, New York Times book reviewer Dwight Garner talks about his experience as a critic—the required credentials (or lack thereof), how to cut through the hype, the role of negative reviews, and more.
by Staff
Daily News
Online Only, posted 10.2.14
National Poetry Day in the U.K., a new James Bond novel in the works; Shel Silverstein's The Giving Tree turns fifty; and other news.
Online Only, posted 10.1.14
Lena Dunham decides to pay book tour performers; A Fault In Our Stars banned in California school district; pop songs as Shakespearean sonnets; and other news.
Online Only, posted 8.28.14
Robert Hass wins Wallace Stevens Award; two new typewriter apps for the iPad; against "against"; and other news.
Online Only, posted 7.30.14
Warner Bros. and RatPac option The Goldfinch; Macmillan expands library e-book program; Nikki Giovanni on NPR's final episode of Tell Me More; and other news.
Online Only, posted 7.8.14
First edition of Das Kapital sells for $40,000; Costco pulls book by conservative author; Mary Dougherty named director of University of Massachusetts Press; and other news.
Online Only, posted 5.9.14
HarperCollins announces sales increase; Oyster reaches new benchmark; a close reading of Jennifer Weiner's work; and other news.
Online Only, posted 4.23.14
Amazon's control of the U.K. market; Alicia Silverstone's parenting advice; which birds are the most faithful partners; and other news.
Subscribe to P&W Magazine |
Donate Now |
Advertise |
Sign up for E-Newsletter |
Help |
About Us |
Contact Us |
View Desktop Site
© Copyright Poets & Writers 2015. All Rights Reserved


text:
Question: Do black holes spin? What makes galaxies stay semi organised while precessing around it? I don't know how else to word that. Physics is hard. – Nathan
Answer: Yes, it is believed that black holes do spin. The stars in galaxies stay organized over long periods of time while the galaxy rotates due to the mutual gravitational attraction of the stars, gas, and dust in galaxies. That gravitational force balances any forces that might pull a galaxy apart, making the galaxy maintain a stable configuration over many millions of years.
Jeff Mangum


text:
Playstation 3 Games
Okami HD Cheats for Playstation 3Home / Playstation 3 /
This page contains Cheats for Okami HD organized by sections for Playstation 3. This game has "Action Adventure" as genre, made by Hexadrive, released on Oct 30, 2012. If you can't find a hint or secret in our list, then please check this page periodically for the latest updates.
Game Boxshot & Details
- Developer: Hexadrive
- Publisher: Capcom
- Genre: Action Adventure
- Release: Oct 30, 2012
- ESRB: Teen
Game Unlockables
From: ralphkaroy
From: GTACHRIS
From: RRabbit42
Game Questions
Stuck on this game? Set a specific, clearly defined question and let other gamers answer your question or view answers to previously asked questions. If you think you are an expert then please try to help others with their questions.
Ask a Question
Videos You May Like...
Guns Up! - E3 2014 Live Coverage Trailer
- Sep 29, 2015, Views: 9
Tony Hawk's Pro Skater 5 - Gameplay Video
- Sep 29, 2015, Views: 12
Samurai Warriors 4-II - Cooperative online play Trailer
- Sep 29, 2015, Views: 8
All Latest Videos
Extreme Exorcism - Gameplay Video
- Sep 25, 2015, Views: 9
Game Related Options
New Released Games
- Pool Nation FX, (PC)
- The Incredible Adventures Of Van Helsing: Final Cut, (PC)
- Forge Of Empires, (iPhone-iPod)
- Vortex: The Gateway, (PC)
- Devils And Demons, (PC)
- Sayonara UmiharaKawase, (PC)
- Transformers: Devastation, (PS3)
- Transformers: Devastation, (PS4)
- Nubs' Adventure, (PC)
Top Featured Games
- Knights Of Pen And Paper 2, (PC)
- Kung Fu Panda: Showdown Of Legendary Legends, (3DS)
- Starlight Drifter, (PC)
- Dig It! The Digger Simulator, (PC)
- Animal Gods, (PC)
- Monster High: Ghoul School, (Xbox360)
- Adventure Time: Finn And Jake Investigations, (PS4)
- Goosebumps, (3DS)
- Fireman Sam: To The Rescue, (3DS)
Games You May Like
- Mos Speedrun 2, (iPhone-iPod)
- [the Sequence], (iPhone-iPod)
- Snail Bob 2, (iPhone-iPod)
- Blackwell 4: Deception, (iPhone-iPod)
- Forgotten Ball, (iPhone-iPod)
- Gamebook Adventures 12: Asuria Awakens, (iPhone-iPod)
- Gamebook Adventures 11: Songs Of The Mystics, (iPhone-iPod)
- HoPiKo, (iPhone-iPod)
- AZZL, (iPhone-iPod)
- Tile Tales - Charming Number Puzzle, (iPhone-iPod)
- Micro World Evolution - To Live Means To Struggle! PRO, (iPhone-iPod)
- Buried Town, (iPhone-iPod)


text:
Coral Sands Inn, Ormond Beach
- Free WiFi and free parking
Main amenities
- 68 smoke-free guestrooms
- On a private beach
- Outdoor pool
- Beach cabanas
- 24-hour front desk
- Coffee/tea in the lobby
- Air conditioning
- Daily housekeeping
- Front desk safe
- Self-serve laundry
- Picnic area
- Barbecue grills
What's around
- Tom Renick Park (1.1 mi / 1.8 km)
- Al Weeks Sr. North Shore Park (1.3 mi / 2 km)
- Michael Crotty Bicentennial Park (1.7 mi / 2.7 km)
- Roberta Drive Fishing Dock (1.8 mi / 2.8 km)
- Birthplace of Speed Park (1.8 mi / 2.9 km)
We found the hotel online, booked and wee completely blown away when we arrived!! Room…
The room was very clean. The service was outstanding! The location perfect to be near the…
Enter dates to check prices
Hotel Info: 866-539-8117from $76
- Standard Room, 2 Queen Beds, Ocean View
Also popular with travelers from the USA
At a glance
Key facts
Hotel size
- This hotel has 68 rooms
- This hotel is arranged over 5 floors
- Check-in time starts at 3 PM
- Check-out time is 11 AM
- Express check-in/out
Required at check in
- Credit card or cash deposit required
- Government-issued photo ID required
Travelling with others
- Pets not allowed
Extra people
- Roll-away beds available, charges may apply*
- Free WiFi in public areas
- Free WiFi in rooms
- Free self parking
Other information
- Smoke-free property
Nearby Two Star Ormond Beach hotels
In the hotel
- Coffee/tea in the lobby
- Barbeque grills
- On private beach
- Beach cabanas (surcharge)
- Outdoor pool
- Free use of nearby fitness center
- Fishing on site
- Surfing/boogie boarding on site
- Golfing nearby
- Kayaking nearby
- Parasailing nearby
- Beach sun loungers
- Beach towels
- 24-hour front desk
- Laundry facilities
- Free newspapers in lobby
- Number of buildings/towers - 1
- Elevator/lift
- Safe-deposit box at front desk
- Picnic area
- Television in lobby
- Accessibility equipment for the deaf
In the room
- Air conditioning
- Ceiling fan
- Coffee/tea maker
- Iron/ironing board
- Private bathroom
- Hair dryer
- Cable TV channels
- Free WiFi
- Free local calls
- Refrigerator
- Microwave
- Daily housekeeping
- Connecting/adjoining rooms available
- Access via exterior corridors
Top Ormond Beach hotels
Recently reviewed hotels in Ormond Beach
- Lexington Inn & Suites Daytona BeachFrom
- Hyatt Place Daytona Beach - OceanfrontFrom
- Red Roof Inn Palm CoastFrom
"It was nice!"Sep 3, 2015
- Hawaiian Inn Daytona Beach by Sky Hotels and ResortFrom
"My husband and I got away for the night and we booked a room here. Wonderful front desk personal. Room was great, bed comfortable, great view of pool and beach from our balcony.…"Sep 3, 2015
Nearby hotels
Coral Sands Inn, Ormond Beach's small print
Also known as
- Coral Sands Cottages
- Coral Sands Inn
- Coral Sands Inn & Seaside Cottages
- Coral Sands Inn & Seaside Cottages Ormond Beach
- Coral Sands Seaside Cottages
- Coral Sands Seaside Cottages Ormond Beach
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.
Optional extras
Late check-out can be arranged for an extra charge of USD 30.00
Rollaway beds are available for USD 15.00 per stay
Cribs/Infant beds are available for USD 15.00 per stay
We have included all charges provided to us by this hotel. However, charges can vary, for example, based on length of stay or the room you book.


text:
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
- Free High-Speed Internet
- Room service
Travelers also recommend:
TripAdvisor Reviews Milano Trieste
Travel Blogs from Trieste
Time to Rest
We left our lovely lake and drove out of Austria into Italy through some Alps which was once again amazing. It was a wonderful drive and more amazingly it felt like it should be cold but the air was already warm when you put your hand out the window. Once we left the Alps as we got further into Italy the temperatures really ramped up. After a ten day break it was a bit of a shock to the system to be so hot once more. We stopped near Trieste by the sea, crossed the road and jumped ...
First Fail
... is delightful as is Piran which is like a mini Venice. A dedicated bike path connects the two which is very flat considering the hills it is surrounded by....should have taken that route on my run yesterday!!
We have not really gotten into the Slovenian cuisine as it appears to be squid and white fish, not really our thing but if you like that type of food it is very well priced.
Anyway I'm off for another frozen Margarita xx
My Presentation Day!
Today is my presentation day! My presentation was in the first morning session on the subject of viral gene expression, after the coffee break. Before my presentation, I couldn't really focus on anything else so that is all I really worked on until then. Thankfully, my presentation went well and Tyshia was kind enough to take a picture of ...
First Day in Trieste!
... with no problems at all. Our hotel is quaint and nice, with air conditioning thankfully, although it didn't work that well.
We freshened up and met up with another friend, Molly, attending the meeting who is an instructor at BWH. We wandered over to Pizzeria Vesuvius di Vassallo Francesco to share some delicious Italian pizzas for dinner. ...
Saturday 20th June – Weds 1st July 2015, Ita
On Saturday morning, we meet my parents early and drive in convoy to Mt .Vesuvius. It is steep (the 'Mt.' should have given us a clue there…) so Ruby struggles and when we stop, my parents say they were worried about her because we were so slow. We laugh and admit that Ruby finds mountains and steep inclines somewhat difficult. We have a campervan breakfast and then make our way up the mountain. It is quite a climb and feels steep in the heat, but it is worthwhile, as when we ...


text:
Page 1
Genes, Brain and Behavior (2008), 7 (Suppl. 1), 67–82
# 2007 The Author
Journal compilation # 2008 Blackwell Publishing Ltd
Cerebral amyloid angiopathy: pathogenetic
mechanisms and link to dense amyloid plaques
S. Kumar-Singh*,†,‡
†Neurodegenerative Brain Diseases Group, VIB Department
of Molecular Genetics, and
Institute Born Bunge, University of Antwerp, Antwerpen,
*Corresponding author: S. Kumar-Singh, Neurodegenerative
Brain Diseases Group, VIB Department of Molecular Genetics,
University of Antwerp, Universiteitsplein 1, BE-2610, Antwerpen,
Belgium. E-mail: email@example.com
‡Laboratory of Neurogenetics,
Cerebral amyloid angiopathy (CAA) of the amyloid-b
(Ab) type is the most common form of sporadic CAA and
is now also accepted as an early and integral part of
Alzheimer's disease (AD) pathogenesis. Cerebral amy-
loid angiopathy is a risk factor for haemorrhagic stroke
and is believed to independently contribute to dementia.
Rare forms of hereditary cerebral amyloidosis caused by
mutations within the Ab domain of amyloid precursor
protein (APP) have been identified, where mutant Ab
preferably deposits in vessels because of a decreased
fibrillogenic potential and/or increased vasotopicity. A
review of factors involved in CAA caused by wild-type
Ab suggests that increased Ab levels in brain without
an increased Ab42/Ab40 ratio is one of the most
important prerequisites for vascular amyloidosis. This
is exemplified by CAA observed in APP duplication and
Down's syndrome patients, neprilysin polymorphism
patients and knockout mice and Swedish APP (KM670/
671NL) mice. Select presenilin mutations also lead to
a prominent CAA, and importantly, presenilin muta-
tions are shown to have varied effects on the pro-
duction of Ab40, the predominant amyloid found in
CAA. Conversely, APP mutations such as Austrian APP
(T714I) drastically decrease Ab40 production and are
deficient in CAA. Apolipoprotein E-e4 is also shown to
be a risk factor for CAA, and this might be because of
its specific role in the aggregation of Ab40. Recent data
also suggest that dense-core senile plaques in humans
and dense plaques in transgenic mice, composed pre-
dominantly of Ab40, associate with vessels. This
review highlights some of these aspects of genetics
and biochemistry of CAA and pathological descriptions
linked to a prominent CAA and/or dense plaques in
humans and relevant mouse models and discusses
how this knowledge has led to a better understanding
of the processes involved in vascular amyloidosis, and
in causing dementia, and thus has important therapeu-
tic implications.
Keywords: Alzheimer's disease, amyloid-b protein, CAA,
cerebrovascular amyloidosis, dense-core plaques, pathogen-
esis, senile plaques, therapy, transgenic mice
Received 24 August 2007, accepted for publication 24
October 2007
Cerebral amyloid angiopathy (CAA) refers to pathological
changes occurring in cerebral blood vessels caused by depo-
sition of amyloid protein of different origins. More than 10
different amyloid proteins/peptides are known to deposit in
cerebral blood vessels or in brain parenchyma (Revesz et al.
2002); however, CAA caused by amyloid-b (Ab) peptide is the
most common form in normal ageing in the elderly, sporadic
and familialCAA patients andalmostallpatientsofAlzheimer's
disease (AD) (Revesz et al. 2002; Vinters et al. 1996). While
there are differences of opinion as to what initiates the
cascade of events that leads to AD, there is little doubt that
Ab-CAA is detrimental to vessel structure and function.
However, the mechanisms involved in the formation of CAA,
its link to other cerebral amyloid depositions and mechanisms
by which CAA might cause dementia and contribute to the
AD phenotype are only beginning to be unravelled.
In this review, I have discussed some of these aspects with
a perspective of genetics and pathogenesis of Ab-CAA
(hereafter, CAA) in humans. I have also discussed how data
from mouse models have been critical to our understanding
of Ab clearance mechanisms related to brain vasculature and
howfailure of these mechanisms leads tothe development of
vascular amyloidosis, which according to recent data also
include dense amyloid plaques. The review takes a standpoint
on CAA, although many facts and approaches discussed here
are common to both CAA and dense plaques and support the
idea that CAA–dense amyloid plaques represent a continuum
of cerebral amyloidosis.
Amyloid-b metabolism and toxicity
Ab generation and clearance
Full-length Ab (Ab1-40 or Ab1-42) is generated from amyloid
precursor protein (APP) by a sequential proteolytic activity of
b-secretase (BACE) and the g-secretase/presenilin complex
(De Strooper 2003). A more physiological APP processing by
doi: 10.1111/j.1601-183X.2007.00380.x
Page 2
a- and g-secretase releases a 3 kDa p3 peptide (Fig. 1).
Although these pathways are called amyloidogenic and non-
amyloidogenic pathways, recent studies suggest that p3 is
abundantly secreted and deposited as amyloid in plaques and
vessels (Gowing et al. 1994). These pathways could thus be
more appropriately called 'Ab' and 'non-Ab' pathways with
another caveat that Ab is frequently N-terminally truncated at
sites other than those present in p3 (i.e. peptides starting at
E3 or E11). After APP cleavage, Ab peptide is either retained
within cells (intracellular Ab; see further) or secreted into the
brain interstitial fluid (ISF) as monomers/dimers, where it
further polymerizes into diffusible Ab oligomers. In such
soluble states, Ab is passively redistributed in brain paren-
chyma and cleared (Hardy & Selkoe 2002).
Several Ab clearance mechanisms exist in brain. While Ab
uptake and degradation by macrophages is very well recog-
nized, recently, astroglia have also been proposed to have
a similar function (Wyss-Coray et al. 2003). Accumulating
evidence also implicates proteases as key regulators of Ab
metabolism (Saido & Iwata 2006). At least six distinct (zinc)
metallopeptidases have been implicated in the physiological
degradation of Ab: neprilysin (NEP), insulin-degrading enzyme
(IDE), endothelin-converting enzymes-1 and -2 and matrix
metalloproteinase-2 and -9 (Saido & Iwata 2006). Elevation of
endogenous murine brain Ab has been observed in genetic
knockout models for many of these proteases, including NEP
(Iwata et al. 2001). Parallel studies in overexpression mouse
models of NEP and IDE also show reduction in Ab levels and
retardation of plaque formation (Leissring et al. 2003). In
addition, aggregated Ab increase the expression of plasmin-
ogen activators that in turn degrade Ab fibrils (Tucker et al.
2000). While some of these proteases are active intracellu-
larly, others act on the cell surface or are secreted and
activated in the ISF and are important in regulating extracel-
lular Ab levels (Saido & Iwata 2006) (Fig. 2).
Amyloid-b isalsocleared out ofbrain/central nervous system
(CNS) by two pathways associated with blood vessels. One of
these mechanisms is a direct Ab transport across the blood–
brain barrier (BBB) mediated by low-density lipoprotein recep-
tor-related protein-1 (LRP-1), which in turn is influenced by a2-
This clearance mechanism is highly efficient not only in young
animals but also in partially clearing pathological amounts of Ab
in mouse models transgenic for human genes bearing muta-
tions that cause familial AD (Zlokovic 2005). A second vessel-
related Ab clearance route is along the periarterial ISF drainage
pathways from where Ab reaches the cerebrospinal fluid (CSF)
show that this is equivalent to lymphatics of brain (Weller et al.
1998) and constitutes another major route of Ab elimination in
olderanimals whentheAb transportacrossBBBbecomesless
efficient or when overwhelmed as in mouse AD models
(Calhoun et al. 1999; Shibata et al. 2000). Amyloid-b in CSF
remains at a constant level of ?800 ng/l, irrespective of age
(Sjogren et al. 2001). With all mechanisms combined, Ab
clearance from human brain normally exceeds its production
with Ab fractional production and clearance rates measured as
7.6% and 8.3% per hour, respectively (Bateman et al. 2006).
Similarly, Ab half-life in brains of APP transgenic mice is
measured as ?2 h (Cirrito et al. 2003).
Amyloid-b deposition
While Ab is predominantly secreted as monomers, it is
possible that dimers are also constitutively secreted from
neurons (Kawarabayashi et al. 2004). In the ISF, Ab exists as
monomers, low-molecular-weight (MW) oligomers (e.g.
dimers and trimers), high-MW oligomers (e.g. 56 kDa Ab
assembly and Ab-derived diffusible ligands), protofibrils, and
finally, mature fibrils. Soluble monomers and early aggrega-
tion states do not cross the threshold for immunohistochem-
ical detection, a technique which is more robust in identifying
higher order Ab aggregation states, including loosely arranged
fibrils. Densely packed aggregates, however, are less visible
by immunohistochemistry because of epitope masking. Fi-
brils, especially when densely packed, are readily identified by
Figure 1: Proteolytic processing of APP and generation of Ab. Schematic figure of the longestAPP isoform (APP770)and position of
the Ab sequence and the single transmembrane domain of APP (Tm, highlighted yellow) are indicated. NH2 and COOH indicate
N-terminus and C-terminus of the protein, respectively. Amyloid-b sequence is enlarged below with amino acid numbering (according
to APP770) above the sequence and the amino acid substitution below the sequence. Amyloid precursor protein is cleaved by b- or
a-secretase to result in soluble N-terminus fragments released into the intracellular vesicles or extracellularly (APPs-a or APPs-b) and
C-terminal fragments (C99 and C83) that are retained in the membrane. Full-length Ab40 and Ab42 and p3-40 and p3-42 are formed
by subsequent action of g-secretase at various sites, and this intramembranous cleavage also releases APP intracellular domain (AICD)
in the cytosol. Figure is not drawn to scale.
Genes, Brain and Behavior (2008), 7 (Suppl. 1), 67–82
Page 3
silver impregnation techniques, fibril-binding dyes like Congo
red or thioflavin-S (ThS) and ultrastructural microscopy.
Immunohistochemical studies have shown that intraneuro-
nal Ab42 is the initially deposited Ab form in neurons not
only in AD patients (Gouras et al. 2000) but also in transgenic
APP mice where it appears earlier than, or in the absence
of, extracellular plaques (Van Broeck et al. 2006; Wirths et al.
2001). Moreover, intracellular Ab is in equilibrium with the
extracellular Ab pool and shifts from intraneuronal to extra-
cellular compartment as the disease progresses (Gouras et al.
2000; LaFerla et al. 2007; Wirths et al. 2004). However, at
least in vitro, a small pool of intraneuronal Ab42 has been
observed that is never secreted (Skovronsky et al. 1998).
Diffuse plaques are the first extracellularly visible Ab
deposits observed in AD and Down's syndrome patients
(Gowing et al. 1994; Iwatsubo et al. 1994; Lemere et al.
1996). Immunohistochemical studies have shown that such
plaques are constituted predominantly of N-terminally trun-
cated Ab42. Although Ab fibrils are observed ultrastructurally
(Davies & Mann 1993), a greater sensitivity to Ab immuno-
histochemical detection has led to suggestions that Ab in
these plaques is predominantly nonfibrillar. The diffuse pla-
ques occur mostly perineuronally and occasionally as large
'clouds', for instance, in the subpial layers. These plaques are
not associated with the proximate neurofibrillary pathology
and, perhaps, for this reason are thought to be harmless,
although in aggressive familial disease or in late stages of AD,
diffuse plaques are frequently observed to be associated with
neurofibrillary pathology (Dickson 1997; Kumar-Singh et al.
2000a; Thal et al. 2006). Mechanism of formation of diffuse
of spontaneous aggregation of Ab in a concentration-depen-
dent manner. Nevertheless the role of parenchymal factors
facilitating the initial aggregation process cannot be ruled out.
Diffuse plaques are believed to further 'mature' into dense
plaques such as dense-core plaques, although recent data
suggest that diffuse and dense-core plaques are develop-
mentally and biochemically distinct (Table 1). Dense-core
plaques often contain dystrophic neurites and are therefore
called 'neuritic' or 'classic' plaques. Interestingly, dense
plaques have been shown to have a higher burden of Ab40.
Amyloid-b deposited in vessel wall is also dense and has
a biochemical resemblance to dense-core plaques in that
these are also predominantly composed of Ab40 (Gravina
et al. 1995). Mechanisms of formation of CAA and dense-core
plaques are discussed in Pathogenesis of CAA and dense
amyloid plaques.
Amyloid-b toxicity
Initially, the hypothesis that fibrillar forms of Ab cause
neurotoxicity gained acceptance (Lorenzo & Yankner 1994).
Figure 2: Schematic representation of physiological clearance and pathological deposition of Ab in brain. (a) The newly
synthesized Ab is degraded by macrophages and cell-associated and extracellular proteases such as NEP, IDE, endothelin-converting
enzyme 1 (ECE-1), tissue and urokinase-type plasminogen activators (uPA and tPA) and matrix metalloproteinase (MMP)-2 and -9.
Amyloid-b is also cleared along the periarterial ISF pathway or directly across the BBB through specific receptors or carrier-mediated
mechanisms. It is possible that highly aggregatable Ab42 deposits near the site of production but is cleared by these proteases. (b) Once
the mechanism of clearance fails, diffuse Ab plaques slowly accumulate. It is possible that such plaques could sequester newly
synthesized Ab and mature to dense plaques. However, the majority of Ab gradient flow is towards vessels where Ab42 seeds the
deposition of more abundantly produced, and more diffusible, Ab40 to form vessel-related CAA and dense plaques.
Genes, Brain and Behavior (2008), 7 (Suppl. 1), 67–82
Mechanisms of cerebrovascular amyloidosis
Page 4
However, around the same time, nonfibrillar Ab deposited in
vessel walls was also shown to be associated with smooth
muscle cell (SMC) degeneration in AD patients (Dyrks et al.
1993). In more recent studies, nonfibrillar, diffusible Ab
assemblies such as Ab oligomers are shown to kill mature
neurons in organotypic brain cultures and inhibit hippocampal
long-term potentiation (LTP) (Lambert et al. 1998). Both these
effects are temporally distinct with LTP alterations appearing
earlier than the neurotoxic effect of oligomeric Ab. Subse-
quently, an LTP inhibition caused by Ab oligomers was also
observed in mouse models (Walsh et al. 2002). Specifically,
a 56-kDa Ab dodecamer (Ab*56) was implicated in Tg2576
mouse model (Lesne et al. 2006); however, the generality of
Ab dodecamers as the toxic Ab assembly in other mouse
models and humans remains to be confirmed (for mouse
models discussed in this review, see Table S1. Also visit
http://www.alzforum.org/res/com/tra/default.asp for a more
complete list of AD transgenic mice). In other transgenic
mice, levels of synaptophysin, a widely recognized indicator
of presynaptic terminals, were shown to be reduced without
an overt decrease in neuronal number (Mucke et al. 2000).
Thus, the current consensus is that decline in memory
function in the early stages of AD is because of changes in
synaptic function caused by nonfibrillar, diffusible Ab assem-
blies rather than by loss of neurons or accumulation of fibrillar
Ab. Although this fits well with most mouse models of AD
where significant memory impairment occurs in the absence
of neuronal loss (Dickson 2004), it does not explain why
classically fibrillar plaques in humans are neuritic, while non-
fibrillar, diffuse plaques are non-neuritic. A further complicat-
ing fact is that intraneuronal Ab might also pose toxicity
independent of the extracellular pool (Gouras et al. 2000;
LaFerla et al. 2007; Wirths et al. 2004).
While the debate continues whether and how dense
plaques are toxic to the surrounding neuropil (Pathogenesis
of CAA and dense amyloid plaques), Ab in vessel walls has
been widely accepted to be toxic to the vascular elements.
Several ultrastructural and immunohistochemical studies
have shown that endothelial cells, SMCs and human brain
pericytes (HBP) undergo degeneration in amyloid-laden ves-
sels (Farkas & Luiten 2001; Kawai et al. 1993; Kumar-Singh
et al. 2002a). In vitro studies have also shown that Ab is toxic
to SMCs and HBPs (Davis-Salinas et al. 1995; Verbeek et al.
History and genetics of CAA and
related disorders
Historic identification of CAA and other vascular
abnormalities as a component of AD
Presence of amyloid in blood vessel walls of senile dementia
patients was first described by Scholtz using the congophilic
property of CAA, a quality that till then had been reserved for
amyloid in the senile plaque cores (Scholtz 1938). Since then,
CAA has been extensively characterized in AD patients and
has been shown to affect leptomeningeal and cortical
arteries, arterioles, capillaries, venules and veins in almost
all patients of AD (Mandybur 1975; Vinters et al. 1996).
Neuropathologically, three stages have been observed in
the development of CAA that distinguish between 'mild',
'moderate' and 'severe' involvement. In 'mild' CAA, Ab
deposition is restricted to the tunica media of an otherwise
normal vessel. In 'moderate' CAA, Ab deposition involves the
entire thickness of tunica media, thus completely replacing
the SMC layers. No evidence of recent or old blood leakage is
found. In 'severe' CAA, Ab deposition involves other vascular
wall layers, and the vascular architecture is severely disrupted
with secondary changes such as microangiopathies, micro-
aneurysmal dilatation and fibrinoid necrosis (Mandybur 1986;
Revesz et al. 2002; Vinters et al. 1996). CAA affects arteries,
arterioles and capillaries of cerebral and cerebellar cortices
and leptomeninges more often, whereas vessels in white
matter are usually spared. Moreover, a few cortical regions
like occipital cortex are more frequently affected than others
(Revesz et al. 2002; Vinters et al. 1996). In CAA associated
with capillaries and small arterioles, Ab frequently permeates
the glioadventitial junction and extends into the parenchyma
as 'dyshoric angiopathy' (Scholtz 1938; Surbeck 1961); and
this type of CAA has been shown to be more closely related
Table 1: Extracellular cerebral amyloid deposits commonly present in humans and transgenic mouse models
CAAPathological changes occurring in cerebral blood vessels caused by deposition of amyloid
protein of different origins. Also used loosely for vascular amyloidosis
Amyloid deposition in vascular walls. In this review, also used sometimes to include dense
plaques as these are also associated with vessels
Also referred to as 'neuritic', 'senile', 'classic' or 'mature' plaques. The central compact
dense core is surrounded by a corona of diffuse plaque. The corona contains predominantly
N-terminally truncated Ab42 and is ThS-negative. The core is ThS-positive and, in contrast
to general belief, contains more Ab40, especially full-length Ab1-40 than Ab42
Thioflavin-S-positive compact amyloid without the corona of diffuse plaques. Major compact
plaque type in transgenic mouse models and resembles burnt-out plaques in humans.
Biochemically resembles cores of the dense-core plaques. In this review, also sometimes
used to include dense-core plaques
Loosely arranged fibrils that are usually ThS-negative. Best recognized with immunohistochemistry.
Mostly found perineuronally, and in contrast to general belief, are also fibrillar. Are arguably
constituted predominantly of N-terminally truncated Ab42
Vascular amyloidosis
Dense-core plaques
Dense plaques
Diffuse plaques
Genes, Brain and Behavior (2008), 7 (Suppl. 1), 67–82
Page 5
to AD pathology than CAA affecting larger vessels (Attems &
Jellinger 2004; Vinters et al. 1996).
Another aspect of vascular abnormalities as a component
of AD is vascular dementia (VaD) caused by the concurrent
presence of cerebrovascular diseases. Interestingly, vascular
changes were already described in the first recorded case of
AD (Alzheimer 1907). In recent studies, AD and VaD have
been observed to frequently overlap with 60–90% of AD
patients exhibiting variable cerebrovascular pathology, of
which almost 30% show evidence of cerebral infarction
(see also Clinical manifestations of CAA). It is very likely that
AD and VaD represent a clinicopathological spectrum in
a routine clinical setting (Kalaria 2002).
APP mutations in hereditary cerebral amyloidosis
Purification and biochemical characterization of deposited
amyloid in AD and Down's syndrome patients led to the
identification of Ab peptide and APP gene (Glenner & Wong
1984). Interestingly, such identification was initially made
from vascular amyloid and only a year later confirmed for
amyloid present in the senile plaque cores (Masters et al.
Similarly, molecular genetic analysis also began earlier for
CAA than for AD with the first mutation in the APP gene
(E693Q/Dutch APP) identified in families having a rare form of
vascular amyloidosis called hereditary cerebral haemorrhages
with amyloidosis–Dutch type (HCHWA-D) (Levy et al. 1990;
Van Broeckhoven et al. 1990). Hereditary cerebral haemor-
rhages with amyloidosis–Dutch type patients are character-
ized by recurrent haemorrhages and extensive Ab deposition
in cerebral blood vessel walls in the absence of senile plaques
and other features of AD, such as neurofibrillary tau pathology
(van Duinen et al. 1987; Haan et al. 1991; Maat-Schieman
et al. 2000). Subsequently, the APP V717I (London APP)
mutation was identified in a classical AD family (Goate et al.
While the Dutch and London APP mutations led to an
almost pure cerebral haemorrhagic/CAA or an AD phenotype,
soon after the APP A692G (Flemish APP) mutation was
identified in a family that had both cerebral haemorrhage
and AD (Hendriks et al. 1992). The clinical phenotype over-
lapped to the extent that cerebral haemorrhages were
reported in offspring of demented patients, while patients
with strokes had offspring developing progressive dementia
(Kumar-Singh et al. 2002a; Roks et al. 2000). Neuropatholog-
ically, Flemish APP patients showed senile plaques with the
largest central dense cores ever noted in AD and a severe
degree of CAA (Brooks et al. 2004; Cras et al. 1998; Kumar-
Singh et al. 2002a). Also, in contrast to HCHWA-D and
consistent with a clinical diagnosis of AD, Flemish APP
patients have considerable neurofibrillary pathology (Cras
et al. 1998; Kumar-Singh et al. 2002a).
Subsequently, other APP mutations in the proximity of the
a-secretase site were identified such as 'Arctic' (E693G),
'Italian' (E693K), 'Iowa' (D694N) or the L705V mutation
(Grabowski et al. 2001; Kamino et al. 1992; Miravalle et al.
2000; Nilsberth et al. 2001; Obici et al. 2005). Some of these
mutations resemble the Dutch APP mutation with a predom-
inant haemorrhage phenotype, as is the case with Italian APP
or L705V mutation (Miravalle et al. 2000; Obici et al. 2005).
The Arctic and Iowa APP mutations, however, resemble the
Flemish mutation by leading to a mixed AD/CAA clinical
phenotype and also neuropathologically confirmed for Iowa
mutation carriers (Grabowski et al. 2001; Kamino et al. 1992;
Nilsberth et al. 2001) (Fig. 1; see also the complete list of
APP mutations on www.molgen.ua.ac.be/ADMutations). All
these mutations not only alter APP cleavage but also change
the primary Ab sequence and thus the fibrillogenic potential
of the resulting mutant Ab peptide. Development of CAA
in these hereditary pathologies might be because of the
combined effect of mutant Ab and an altered APP cleavage,
as discussed in Pathogenesis of CAA and dense amyloid
APP gene dosage and CAA
Several independent duplications of the APP locus have also
been identified in French families with an autosomal domi-
nant AD and/or lobar cerebral haemorrhage with prominent
CAA (Rovelet-Lecrux et al. 2006). The overriding component
of CAA in patients with APP duplication has also been
confirmed in a Dutch population-based study (Sleegers et al.
2006). Similarly, Down's syndrome patients, also with three
copies of APP, are detected to have CAA as young as 30
years, and the severity of CAA increases with age (Lemere
et al. 1996). Although not common, Down's syndrome
patients are also reported to have strokes (Belza & Urich
1986; Donahue et al. 1998; McCarron et al. 1998). While there
could be many explanations for increased prevalence of CAA
in APP duplication patients, the fact that such a genotype
coerces increased total Ab without an increase in the Ab42/
Ab40 ratio suggests that increased Ab40 levels are important
for CAA development. To further support this premise,
carriers of the Swedish double APP mutation (KM670/
671NL) that leads to increased Ab production without an
altered Ab42/Ab40 ratio also have a higher proportion of Ab40
peptide deposited in brain compared with the London APP
carriers who have increased Ab42 at the cost of Ab40 (De
Jonghe et al. 2001; Mann et al. 1996). As CAA and dense
plaques are the preferred sites for Ab40 deposition, it would
be interesting to study whether Swedish APP patients or
patients with increased APP expression because of APP
promoter polymorphisms (Theuns et al. 2006) would similarly
have a prominent presence of CAA and dense plaques in
Presenilin regulation of CAA
Some AD-linked presenilin (PS)-1 mutations are associated
with marked CAA (Dermaut et al. 2001; Ikeda et al. 1996;
Singleton et al. 2000; Wegiel et al. 1998; Yasuda et al.
1997). Cerebral amyloid angiopathy is also reported in the
Volga-German AD family with PS2 N141I mutation associ-
ated with haemorrhagic strokes (Nochlin et al. 1998). While
a certain degree of intrafamilial diversity noted in these
families suggests the potential role of additional risk factors
for development of CAA, differential APP processing by
Genes, Brain and Behavior (2008), 7 (Suppl. 1), 67–82
Mechanisms of cerebrovascular amyloidosis


text:
Cubs Minor League Recap: 9/2/15
Myrtle Beach held on to grab a win, but Iowa, South Bend and Eugene all were on the losing end Wednesday. Tennessee had the day off, while Mesa's season finished up Tuesday. Here are some notes from yesterday's minor league Cubs action:
Iowa Cubs (78-61)
Pacific Coast League (Triple-A)
T-Second Place (-6.0)
Iowa was officially eliminated from playoff contention, falling 11-3 on the road at Oklahoma City.
- C Taylor Davis (.303) went 3-for-4 with a double (18), a walk, a run scored and an RBI (27). He has hit safely in five straight games (.520/13-for-25), including four three-hit efforts.
- LF Emilio Bonifacio (.429) went 2-for-4 with a walk and two runs scored and has gone 10-for-15 with five walks and six runs scored in his last four games.
- LHP Zac Rosscup (5.23) tossed a perfect inning of relief, striking out two batters.
Myrtle Beach Pelicans (37-26)
Carolina League (High-A)
Second Place (-4.0)
Myrtle Beach scored three runs in the sixth inning and held on for a 4-2 victory over Potomac.
- C Victor Caratini (.253) went 1-for-4 with a double (29), two RBI (52) and a run scored.
- SS Gleyber Torres (.000) made his Myrtle Beach debut, going 0-for-2 with a walk.
- RHP Jonathan Martinez (2.58) has gone 3-0 with a 0.30 ERA (1 ER/30.0 IP) in his last five starts. He picked up the win Wednesday, pitching 6.0 scoreless innings. He has not allowed a run in 18.0 consecutive innings.
South Bend Cubs (33-32)
Midwest League (Low-A)
T-Third Place (-9.0)
South Bend surrendered 15 hits in a 10-1 setback against Dayton.
- LF Charcer Burks (.266) went 2-for-4 with a triple (4) and a run scored. He has five runs in his last three games.
- 1B Gioskar Amaya (.266) finished 2-for-4 with two doubles (18) and an RBI (43).
- SS Vimael Machin (.165) went 1-for-2 with a walk.
Eugene Emeralds (20-14)
Northwest League (Short-Season A)
First Place (+1.0)
Eugene dropped a 3-2 decision at Salem-Keizer. The Emeralds hold a one-game lead in the division with four games remaining.
- SS Andrew Ely (.315) went 3-for-4 with a double (13). It was his third game with at least three hits.
- CF Donnie Dewees (.268) went 2-for-3 with a walk and an RBI (14).
- RHP Oscar De La Cruz (2.84) gave up one earned run in 6.0 innings. He has allowed one run or fewer in four of his last six starts.
Cubs Lineup: 9/2/15
Cubs vs. Reds — Wrigley Field
First Pitch: 1:20 CST
Cubs Starter: Jason Hammel, RHP (7-6, 3.42)
Reds Starter: Raisel Iglesias, RHP (3-6, 3.92)
TV: CSN Chicago; Radio: WBBM 780 AM
1. Dexter Fowler, CF
2. Kyle Schwarber, LF
3. Chris Coghlan, RF
4. Anthony Rizzo, 1B
5. Kris Bryant, 3B
6. Miguel Montero, C
7. Addison Russell, SS
8. Jason Hammel, P
9. Tommy La Stella, 2B
Cubs open the month with a flurry of roster moves
Javier Baez returns to the Cubs lineup. (Photo by Stephen Green)
The Cubs Tuesday recalled infielder Javier Baez and left-handed pitcher Tsuyoshi Wada from Triple-A Iowa, activated catcher David Ross off the family medical emergency leave list and added outfielder Austin Jackson to the active roster. Additionally, the Cubs have selected the contracts of outfielder Quintin Berry (postgame last night) and right-handed pitcher Trevor Cahill (today) from Triple-A.
To make room for Berry and Cahill on the 40-man roster, left-handed pitcher James Russell was designated for assignment and right-handed pitcher Rafael Soriano was activated from the 15-day disabled list and designated for assignment. Chicago's 40-man roster now stands at 40, and the active roster is at 30 players.
Berry will wear uniform No. 5, Cahill will wear uniform No. 53 and Jackson will wear uniform No. 27.
Baez, 22, batted .324 (91-for-281) with 14 doubles, two triples, 13 home runs, 61 RBI and 17 stolen bases in 70 games with Iowa this season. He turned in a .385 on-base percentage and .527 slugging percentage, good for a .912 OPS, and joins the Cubs riding a 16-game hitting streak. Baez made his major league debut last season and batted .169 with six doubles, nine homers and 20 RBI in 52 games. He was Chicago's first round pick (ninth overall) in the 2011 Draft.
Berry, 30, signed a minor league deal with the Cubs on Aug. 24 after spending the entire season with Boston's Triple-A Pawtucket affiliate, where he batted .228 with a .329 on-base percentage and 35 steals in 106 games. He has spent parts of three major league seasons with Detroit (2012), Boston (2013) and Baltimore (2014), batting .266 with a .337 on-base percentage in 117 games, and is a perfect 25-for-25 in stolen base attempts in the regular season and a perfect 5-for-5 in the postseason.
Cahill, 27, signed a minor league deal with the Cubs on Aug. 18 and turned in five scoreless relief outings with Iowa, covering 7.2 innings. The right-hander broke into the big leagues with Oakland in 2009 and was an 18-game winner a season later, going 18-8 with a 2.97 ERA in 30 starts, earning AL All-Star honors along the way. Overall, Cahill won 10 or more games in four straight seasons (2009-12) and is 64-72 with one save and a 4.16 ERA in 201 major league outings (28 in relief) with Oakland (2009-11), Arizona (2012-14) and Atlanta (2015).
Jackson, 28, was acquired Monday from Seattle, where he batted .272 with 18 doubles, three triples, eight home runs, 38 RBI, 46 runs scored and 15 stolen bases in 107 games this season. Since making his major league debut with Detroit in 2010, Jackson has batted .273 with 163 doubles, 47 triples, 54 home runs and 286 RBI in 831 career games, all of which have come in center field.
Ross, 38, is batting .190 with one home run and seven RBI in 57 games with the Cubs this season. He owns a 2.73 catchers' ERA in his 44 games (35 starts) behind the plate.
Wada, 34, returns to the Cubs after going 1-1 with a 3.73 ERA in seven starts earlier this season. With Iowa, Wada went 4-5 with a 3.95 ERA in 16 starts. He made his big league debut with the Cubs last year and has combined to go 5-5 with a 3.40 ERA in 20 major league starts over the last two years.
Russell, 29, went 0-2 with one save and a 5.29 ERA in 49 relief appearances with the Cubs this season.
Soriano, 35, went 2-0 with a 6.35 ERA in six relief appearances for the Cubs this season.
Cubs Lineup: 9/1/15
Cubs vs. Reds — Wrigley Field
First Pitch: 7:05 CST
Cubs Starter: Dan Haren, RHP (8-9, 3.90)
Reds Starter: Anthony Desclafani, RHP (7-10, 3.84)
TV: WGN-TV; Radio: WBBM 780 AM
1. Dexter Fowler, CF
2. Kyle Schwarber, LF
3. Chris Coghlan, RF
4. Anthony Rizzo, 1B
5. Kris Bryant, 3B
6. Miguel Montero, C
7. Javier Baez, 2B
8. Dan Haren, P
9. Addison Russell, SS
Cubs Minor League Recap: 8/31/15
Iowa, Tennessee and South Bend all reeled off victories Monday, while everybody else was off. Here are some notes from yesterday's minor league action:
Iowa Cubs (78-58)
Pacific Coast League (Triple-A)
Second Place (-3.0)
Iowa extended its winning streak to six games, topping Oklahoma City, 9-3.
- 1B Taylor Davis (.293) went 3-for-4, recorded three RBI (25), drew a walk and scored once. He has back-to-back three-hit games.
- LF Mike Baxter (.279) finished 1-for-4 with two RBI (19), a walk and one run scored.
- CF John Andreoli (.281) was 1-for-4, drew two walks, scored twice and swiped a bag (30).
- 3B Christian Villanueva (.264) went 1-for-2, drove in one (83), scored once and drew a season-high three walks. He extended his hitting streak to five games (.400/8-for-20).
Tennessee Smokies (34-40)
Southern League (Double-A)
T-Second Place (-6.0)
Tennessee claimed its sixth straight victory, rolling past Jacksonville, 9-1.
- CF Albert Almora (.276) went 2-for-4 with a double (26), a triple (4), a walk, two runs scored and one RBI (46). He has hit safely in 12 straight games (.360/18-for-50).
- SS Ryan Dent (.256) extended his hitting streak to six games (.545/12-for-22), going 2-for-2 with a walk, a run scored and an RBI (24).
- C Willson Contreras (.326) and 1B Dan Vogelbach (.284) each recorded two hits in five at-bats.
- RF Bijan Rademacher (.260) went 1-for-3 with a bases-clearing triple (4), one run scored and a season-high four RBI (43).
- RHP Ryan Williams (2.79) has allowed one earned run or fewer in at least 6.0 innings in five of his last six outings. He pitched 6.0 scoreless on Monday to secure the win.
South Bend Cubs (32-31)
Midwest League (Low-A)
T-Third Place (-9.0)
South Bend scored five runs in the second inning and cruised to a 10-4 victory over Bowling Green.
- RF Jeffrey Baez (.287) went 2-for-5 with a grand slam (9) and two runs scored.
- DH Charcer Burks (.266) went 3-for-5 with a double (22), three RBI (44), a stolen base (28) and two runs scored.
- LF Ian Happ (.252) finished 2-for-5, including his eighth double.
- CF Rashad Crawford (.279) went 1-for-3 with a homer (4), two RBI (48), a walk and two runs scored.
- 1B Gioskar Amaya (.266) went 2-for-5, hit two doubles (16), plated one (42) and scored once.
- RHP Trevor Clifton gave up one earned run in 6.0 innings, striking out three in the win.
Cubs Lineup: 8/31/15
Cubs vs. Reds — Wrigley Field
First Pitch: 7:05 CST
Cubs Starter: Kyle Hendricks, RHP (6-6, 4.11)
Reds Starter: Michael Lorenzen, RHP (3-8, 5.46)
TV: CSN; Radio: WBBM 780 AM
1. Dexter Fowler, CF
2. Kyle Schwarber, C
3. Chris Coghlan, LF
4. Anthony Rizzo, 1B
5. Kris Bryant, RF
6. Tommy La Stella, 3B
7. Starlin Castro, 2B
8. Kyle Hendricks, P
9. Addison Russell, SS
Cubs Minor League Recap: 8/30/15
Every Cubs affiliate in action picked up a win Sunday, while Myrtle Beach was rained out. Mesa had the day off as Arizona League playoffs begin Monday. Here are some notes from yesterday's minor league action:
Iowa Cubs (77-58)
Pacific Coast League (Triple-A)
Second Place (-4.0)
Iowa extended its winning streak to five games, topping Sacramento, 9-1. The I-Cubs picked up six doubles in the victory.
- 3B Javier Baez (.324) went 4-for-5, drove in one (61) and scored twice. He extended his season-high hitting streak to 16 games (32-for-72/.444).
- 2B Emilio Bonifacio (.333) also went 4-for-5 with two doubles, plated two runs and scored twice.
- C Taylor Davis (.284) finished 3-for-5 with a double (15) and an RBI (22).
- CF John Andreoli (.282) went 2-for-4, drew a walk, scored three times and stole a base. He leads the team with 29 swiped bags.
- 1B Christian Villanueva (.263) went 2-for-4 with a double (21) and two RBI (82), extending his hitting streak to four games (.389/7-for-18) with seven RBI during that stretch.
- RHP Dallas Beeler (4.17) tossed a season high 8.0 innings and earned his sixth straight win. He struck out seven and walked just one, giving up no earned runs.
Tennessee Smokies (33-30)
Southern League (Double-A)
T-Second Place (-6.0)
Tennessee won its fifth straight game, defeating Jacksonville, 4-3. The Smokies look for the series sweep tonight.
- 3B Jeimer Candelario (.292) crushed a home run (4), going 2-for-2 with two walks and two runs scored.
- SS Ryan Dent (.249) went 3-for-4, extending his hitting streak to five games (10-for-20/.500).
- 2B Stephen Bruno (.267) went 2-for-4, swiped a base (9) and scored once.
- RHP Felix Pena (3.89) snapped his six-game losing streak, earning the win after allowing just three runs (two earned) over 7.0 innings of work.
South Bend Cubs (31-31)
Midwest League (Low-A)
T-Third Place (-9.0)
South Bend topped Bowling Green in the series opener, 4-3.
- CF Ian Happ (.246) went 2-for-4 with a homer, a double (7) and two runs scored.
- DH Rashad Crawford (.279) went 1-for-4 with a double (15) and plated his 46th RBI.
- 1B Kevin Encarnacion (.271) earned an RBI (15) despite going 0-for-4.
- RHP Erick Leal (4.04) earned his third consecutive win, tossing 6.0 scoreless frames and giving up two hits.
Eugene Emeralds (19-13)
Northwest League (Short-Season A)
First Place (+1.0)
Eugene avoided the series sweep, besting Hillsboro in the series finale, 10-4.
- DH Ian Rice (.264) went 2-for-4, knocked a double (8) and a homer (2), drove in two (19) and scored twice.
- 1B Blake Headley (.234) went 2-for-4 and scored once.
- CF Donnie Dewees (.268) finished 2-for-5, drove in one (28), swiped a base (16) and scored once.
- LF Eloy Jimenez (.284) went 2-for-5 and scored once, marking his second straight multi-hit game.
- LHP Carson Sands (3.98) tossed his second quality start of the season, fanning five and giving up one earned run in 6.0 innings.
Cubs Lineup: 8/28/15
Cubs vs. Dodgers — Dodger Stadium
First Pitch: 9:10 CST
Cubs Starter: Jason Hammel, RHP (7-5, 3.35)
Dodgers Starter: Clayton Kershaw, LHP (10-6, 2.29)
TV: WGN, MLB Network: Radio: WBBM 780 AM
1. Dexter Fowler, CF
2. Chris Denorfia, RF
3. Kris Bryant, 3B
4. Anthony Rizzo, 1B
5. Starlin Castro, 2B
6. Matt Szczur, LF
7. Miguel Montero, C
8. Jason Hammel, P
9. Addison Russell, SS
Cubs Minor League Recap: 8/27/15
Iowa and Eugene continued their winning ways, and Tennessee rolled to a victory Thursday. But Myrtle Beach and South Bend were defeated in one-run games, while Mesa was rained out. Here are some notes from yesterday's minor league Cubs action:
Iowa Cubs (74-58)
Pacific Coast League (Triple-A)
Second Place (-6.0)
Iowa has won five of its last six games, after defeating Sacramento, 3-1.
- LHP Tsuyoshi Wada (3.95) gave up one run in 6.2 innings to get the win.
- 2B Javier Baez (.316) went 1-for-4 with a run scored and a stolen base (17), extending his hitting streak to 13 games (.439/25-for-57) with 12 runs scored and 13 RBI during that stretch.
- 1B Christian Villanueva (.259) finished 2-for-4 with two RBI (77). He has 12 RBI in his last 11 games.
- SS Chris Valaika (.268) went 2-for-3 with a solo home run.
- 3B Mike Olt (.257) added a multi-hit game, going 2-for-2 with a walk.
Tennessee Smokies (30-30)
Southern League (Double-A)
Third Place (-7.0)
The Smokies claimed the rubber game of a five-game set at Chattanooga, 7-1.
- DH Taylor Davis (.319) went 3-for-4 with a double (7), an RBI (14) and a walk.
- C Willson Contreras (.329) was 2-for-4 with a double (32), two runs scored and two RBI (72). He has four multi-hit games in his last five contests and is batting .363 (37-for-102) in 27 August games.
- 3B Jeimer Candelario (.287) went 2-for-4 with a walk, a run scored and an RBI (20).
- LHP Jeffry Antigua (4.50) recorded his longest scoreless outing of the season, allowing just four hits in 6.0 innings.
Myrtle Beach Pelicans (35-24)
Carolina League (High-A)
Second Place (-1.5)
Myrtle Beach dropped its series opener against Wilmington, 3-2.
- 2B Chesny Young (.331) extended his hitting streak to seven games (.321/9-for-28) with a 2-for-4 effort.
- C Victor Caratini (.249) went 2-for-4 with a double (26). It was his third-straight multi-hit game.
- 1B Jacob Rogers (.252) finished 1-for-4 with a double (18), a run scored and an RBI (65).
- RHP Daury Torrez (3.86) gave up two earned runs and struck out five in 7.0 innings. He has tossed three straight quality starts, posting a 2.84 ERA (6 ER/19.0 IP).
South Bend Cubs (29-30)
Midwest League (Low-A)
T-Third Place (-11.0)
South Bend dropped its third straight game, falling 4-3 in the series opener versus Great Lakes.
- RF Jeffrey Baez (.277) went 2-for-5. He is batting .376 (38-for-101) in 22 August games.
- 1B David Bote (.259) finished 2-for-4 with an RBI (38).
- CF Charcer Burks (.267) reached three times, going 1-for-2 with a double (21), a run scored and two walks. He has five walks in his last two games after drawing five walks in his previous 19 contests.
- RHP Dillon Maples (3.76) tossed 3.0 scoreless innings of relief, allowing two hits and fanning two.
Eugene Emeralds (18-11)
Northwest League (Short-Season A)
First Place (+2.0)
First-place Eugene won its fourth straight game, topping visiting Spokane, 2-1.
- 3B Adonis Paula (.267) went 1-for-3 with a solo home run in the fifth inning to open the scoring.
- SS Andrew Ely (.321) finished 1-for-3 with a walk and scored the game-winning run in the eighth.
- RHP Adbert Alzolay (2.09) collected his fifth win, tossing 6.0 innings of relief. He allowed two hits and one run while striking out nine batters. It was his seventh relief outing of at least 4.0 innings.
Cubs 12th Homestand Events and Promotions: 8/31/15-9/6/15
(Photo by Stephen Green)
The Chicago Cubs return to Wrigley Field to host a series vs. the Reds from Aug. 31-Sept. 2 and the Diamondbacks from Sept. 4-6. Fans can enjoy events, new food offerings and entertainment throughout the homestand.
Following the game Wednesday, Sept. 2, Cubs manager Joe Maddon and his wife, Jaye, will host Respect the Main Event at Ravenswood Event Center. The charity boxing event will feature several local youth boxers at various skill levels as well as a special main event bout. Guests will be able to sit ringside with Cubs players and enjoy cocktails, hand-rolled cigars and spirits-tasting stations, dinner courtesy of Gibsons Bar & Steakhouse and a premium auction including wine and unique sports memorabilia. A limited number of general admission tickets are available for $300 at cubs.com/maddon. A portion of the net proceeds will benefit the Crushers Club's youth boxing program in Englewood.
The popular #WeAreGood T-shirts will make a return appearance during the Sept. 4 game. The Cubs Wives will offer the T-shirts in the main concourse by Gate F. The shirts, inspired by catcher Miguel Montero's popular Twitter hashtag, will be available for a $25 donation benefiting Cubs Charities and Ronald McDonald House Charities of Chicagoland and Northwest Indiana.
Tickets remain available for each series at cubs.com or 800-THE-CUBS (800-843-2827). Details of the homestand follow.
On Aug. 31, the Cubs will celebrate Military Appreciation Night. Guests with designated Special Group Night Terrace Reserved Outfield tickets will receive a Cubs Armed Forces baseball cap. Special Group Night tickets are available at cubs.com/specialevents.
The following night, Sept. 1, is Healthcare Professionals Night. Guests with designated Special Group Night Terrace Reserved Outfield tickets receive a Cubs scrub top.
On Saturday, Sept. 5, up to the first 10,000 fans will receive a fleece blanket presented by Reynolds Wrap.
Kids Sundays continue Sept. 6. The first 1,000 kids 13-and-under can run the bases postgame, weather permitting.
Guests and Entertainment
On Monday, Aug. 31, members of the World Cup Champion U.S. Women's National Team Lori Chalupny, Julie Johnston and Christen Press will throw the first pitch and sing the seventh-inning stretch.
On Wednesday, Sept. 2, former Cubs pitcher Milt Pappas will sing the stretch on the anniversary of his 1972 no-hitter against the Padres.
On Friday, Sept. 4, John Hermann from the band Widespread Panic will throw a first pitch, and comedian Jon Lovitz will lead the seventh-inning stretch.
Cubs Hall of Fame pitcher Fergie Jenkins will throw a first pitch and lead the stretch Saturday, Sept. 5.
On Sunday, Sept. 6, Stanley Cup Champion Chicago Blackhawks goalie Scott Darling will toss a first pitch, and former Cubs broadcaster and current Arizona Diamondbacks television analyst Bob Brenly will lead the stretch.
Let's Give Charitable Campaign
Fans will have the opportunity to learn more about Cubs Charities programming and give back to the community this homestand as part of this season's ongoing "Let's Give" campaign.
Starting Sept. 1, Cubs Charities, along with the Anthony Rizzo Family Foundation, the Jason Motte Foundation, Jon Lester's NVRQT campaign and Joe Maddon's Respect 90 Foundation, will launch the #LetsGoGold initiative to raise funds for Pediatric Cancer Awareness Month through Sept. 19. Fans can visit cubscharities.org to take part in the fight against cancer by making a donation to the respective nonprofits. The top fundraiser from each nonprofit listed above will receive two tickets and the opportunity to throw a ceremonial first pitch at the Sept. 20 game. Cubs players and coaches will wear gold batting practice jerseys and hats before the team takes on division rival St. Louis Sept. 20. The jerseys and hats, along with signed gold baseballs, will be available for purchase through Cubs Authentics with proceeds benefiting player foundations.
On Thursday, Sept. 3, Maddon and his wife, Jaye, will be back in the community hosting Spoxing for Charity, a one-day pop-up fitness event under the Wrigley Field Marquee. Spoxing is a group class, which combines spinning and boxing, with a warm-up on stationary spin bikes followed by a heavy bag and boxing glove workout. Participants will partake in a 45-minute version of the class, offered during four different sessions, starting at 10 a.m. Net proceeds from the event will benefit Joe Maddon's Respect 90 Foundation. For more information, please visit cubs.com/popup.
On Friday, Sept. 4, the Cubs Wives will offer #WeAreGood T-shirts in the main concourse by Gate F. The shirts, inspired by catcher Miguel Montero's popular Twitter hashtag, will be available for a $25 donation benefiting Cubs Charities and Ronald McDonald House Charities of Chicagoland and Northwest Indiana. Later that day, Cubs manager Joe Maddon will continue his Respect Community charity T-shirt initiative during his postgame press conference. Maddon will represent the Ronald McDonald House Charities of Chicagoland & Northwest Indiana (RMHC-CNI), whose mission is to care for families of children with complex medical needs by providing comfort, compassion and a sense of community. RMHC-CNI keeps families of hospitalized children together in a "home away from home."
Food Specials
The Decade Diner in the right-field concourse will continue its rotating menu of homestand specials with a Chimichurri steak sandwich featuring marinated skirt steak, roasted garlic Chimichurri sauce and grilled onions on flattened torta bread. Guests also can order a breaded chicken sandwich with Cholula, featuring breaded chicken breast, honey ginger slaw and Cholula aioli on a toasted hoagie roll.
Platform 14, the outdoor concession area in the Budweiser Bleachers located behind the center-field scoreboard, will continue serving three Hot Doug's sausages. This homestand will feature three new sausages including the "Gene Clines," a spicy Vienna Polish sausage served with sweet & spicy mustard, caramelized onions and shredded cheddar cheese; the "Dick Tidrow" is a Jamaican jerk pork sausage with cumin dijonnaise, smoked gouda cheese and fried plantain chips; and the "Larry Gura" is a bacon sausage with avocado mayonnaise, shredded lettuce and chopped tomatoes.
Homestand Recap, Aug. 31-Sept. 6
Monday, Aug. 31 vs. Cincinnati Reds, 7:05 p.m.
- Special Group Night: Military Appreciation Night (designated ticket includes Cubs Armed Forces baseball cap)
- National Anthem: Cast of October Sky
- First pitch and seventh-inning stretch: Members of the World Cup Champion U.S. Women's National Team Lori Chalupny, Julie Johnston and Christen Press
- Broadcast: CSN, WBBM 780-AM, Cubs.com
Tuesday, Sept. 1 vs. Cincinnati Reds, 7:05 p.m.
- Special Group Night: Healthcare Processionals Night (designated ticket includes Cubs scrub top)
- National Anthem: Eirini Tornesaki from Cirque du Soleil's KURIOS – Cabinet of Curiosities
- Broadcast: WGN-TV, WBBM 780-AM, Cubs.com
Wednesday, Sept. 2 vs. Cincinnati Reds, 1:20 p.m.
- Seventh-inning stretch: Former Cubs pitcher Milt Pappas
- Broadcast: CSN, WBBM 780-AM, Cubs.com
Friday, Sept. 4 vs. Arizona Diamondbacks, 1:20 p.m.
- First pitch: John Hermann from the band Widespread Panic
- Seventh-inning stretch: Comedian Jon Lovitz
- Broadcast: CSN, MLBN, WBBM 780-AM, WRTO 1200-AM Spanish Radio, Cubs.com
Saturday, Sept. 5 vs. Arizona Diamondbacks, 1:20 p.m.
- Promotional Item: Fleece Blanket presented by Reynolds Wrap (up to the first 10,000 fans)
- First pitch and seventh-inning stretch: Cubs Hall of Fame pitcher Fergie Jenkins
- Broadcast: CSN, WBBM 780-AM, Cubs.com
Sunday, Sept. 6 vs. Arizona Diamondbacks, 1:20 p.m.
- Kids Run the Bases postgame (first 1,000 kids 13-and-under)
- First pitch: Stanley Cup Champion Chicago Blackhawks goalie Scott Darling
- Seventh-inning stretch: Former Cubs broadcaster and current Diamondbacks television analyst Bob Brenly
- Broadcast: WGN-TV, WBBM 780-AM, Cubs.com


text:
Foggy Morning Commute
Video By: Crispin Mayers
Video Details
- Title: Foggy Morning Commute
- Description: Camera is set up at an available window, looking out at the clear view of coming weather changes out of the south.
This Video Has Been Viewed 416 times
0 Comments
You have been blocked from submitting comments.
Add Comment
Click here to view our Interactive Gallery Terms & Conditions.
Get 11 Issues of Outdoor Photographer for only $14.97!
That's 77% off the cover price!
That's 77% off the cover price!


text:
Is this restaurant good for business?
Is this restaurant good for couples?
Is this restaurant family-friendly?
Is this restaurant good for brunch?
Is this restaurant good for lunch?
Is this restaurant good for dinner?
Is this restaurant good for breakfast?
Does this restaurant offer takeout or food to go?
Does this restaurant offer free wifi?
Does this restaurant offer delivery?
Thanks for helping!
Discovered this place just off the Bib Rambla square on our first afternoon - and went back every single evening. Great choice of tapas, beer & wine; and friendly staff too.
3 Days in Granada
One Day in Granada
Best Food in Granada
We found this place while zigzagging through Granada. I was drawn by the nice looking interior and lots of people. We ordered two drinks and received the most delicious meatballs with them. We also ordered the goat cheese with fig and the gulas and shrimp. The gulas had too much of a stong raw garlic taste, but was interesting. The...
I sooo regret stopping at that place for tapas, as the experience was horrible. The food is very basic, and much overpriced, and the service was totally unacceptable. The waiter was rude, and more preoccupied with his mobile phone than requests from the clients. The table next to mine, with 3 Austrian ladies had waited 20min to make drinks order,...
I really love this place! Went here for the first time in september 2014 with a friend who lives in Granada and went back this week with family and it was both times very good. I like the fact that you get a (very tasty) tapa with every drink. Will come back here for sure!
My husband and I stopped here for lunch after a walking tour ending in Plaza Rambla. The wine selection looked excellent, but we were thristy and opted for cervezas whoch came with complimentary olives and ham on bread. The food selections all looked delicious, but we opted for Surtidos de Quesos Europeos, a very ample selections of European cheese and...
My husband and I went to a few tapas bars over the few days we spent in Granada. And every night we ended up back in here after trying tapas in a few places.
I love this Place.
Meal was inedible and should have been sent back to the kitchen, expensive too. Very disappointing for our last night in Granada.
I've been to this restaurant on a Saturday at lunch. The tapas are really good but a bit expensive. And the plates are too big, so you can't try a lot of tapas because of the money you will spend and the quantity of food that is served. The service is a bit rude but the place is amazing. I...
This is in our opinion the best tapas bar in Granada, we stayed in Granada for 3 nights and gravitated here time and time again, the staff are excellent and the experience is amazing, for anyone reading this review you MUST visit here!
We were in Granada in 2012 and found Masquevinos. We went back this year, and found that it still keeps the same high quality as last year.
This place is definitely somewhere to drop by on a tapa night.
Own or manage this property? Claim your listing for free to respond to reviews, update your profile and much more.


text:
|ESPN.com: Sobel
|[Print without images]
|It's pretty clear that Tiger Woods focuses his energy on winning majors. So it only makes sense to use the world's No. 1 player during one of the richest tournaments of the year.
|Expect up-and-coming star Camilo Villegas to notch at least one win in 2009. A good possibility for that next victory might be at Doral in March.


text:
Monaco Property For Sale
The Principality of Monaco is an independent sovereign state set in the heart of Europe, on the Côte dAzur between Cannes and the Italian border. It has a resident population of approximately 35,000 and occupies just over one square mile on the Mediterranean coast. About 20% of the population is Monegasque, the remainder being a cosmopolitan mix of French, Italian, British and most other European nationalities as well as Americans, Canadians, Australians, South Africans, and Middle Eastern Nationals.
The Principality of Monaco has achieved a reputation for being a serious business centre and ideal place of residence for families wishing to live in a very safe and accessible European location with sophisticated facilities, a temperate climate and favourable tax system.
Though French is the official language, English and Italian are widely spoken and understood both in business and socially. English is the preferred foreign language for children in the highly rated local schools and is the predominant language in Monacos International School.
One of Monacos foremost attractions is the high level of security afforded to its residents due largely to the presence of a strong police force. Many of the apartment complexes have 24hr security and concierge for extra peace of mind.
The Principality legislates internally in respect of all matters of direct taxation: Monaco has chosen not to adopt any income tax, capital gains tax or withholding tax legislation. This is good news for anyone looking to purchase real estate in Monaco for a long-term home or for rental purposes.
Though undeniably built-up, Monaco still enjoys various parks and several public and private beaches.
Monaco Property
The Principality is a prestige area and, as such, Monaco property changes hands for considerable sums. There are few bargains to be sought as can be well understood from the density and quality of much of the extant accommodation. However, its tax haven status ensures the market remains buoyant and prices stable so investment in Monaco property continues to be attractive.
Much of the available property in Monaco and Monte Carlo is apartments, from small studios to large luxury triplexes and penthouses. Those overlooking the harbour and Formula 1 circuit are naturally more valuable. There are also a selection of luxury villas and beautiful townhouses but these are usually somewhat more expensive.
Parking difficulties ensure that Monaco properties offering one or two spaces are highly desirable. Private purchase or rental of parking can run into several tens of thousands of Euros and, due to demand, will not necessarily be nearby.
Rental Properties
For properties to rent in Monaco and Monte Carlo, please click here: Monaco Rental Property.
Monaco Property For Sale
3 bedroom Apartment in Monte Carlo, North East Monaco for sale with 43m2 terrace - 10,400,000 EUR
Apartment in Monte Carlo
3 bathrooms
240 sqm (2582.4 sq ft) floor size
Swimming Pool
Highly regarded address at the east entrance of Monaco, with swimming pool on the roof, caretaker's lodge and safety 24/24H. Beautiful apartment in a high calibre building with views over the sea, Mo...
2 bedroom Apartment in Monte Carlo, North East Monaco for sale with 41m2 terrace - 5,300,000 EUR
Apartment in Monte Carlo
2 bathrooms
137 sqm (1474.12 sq ft) floor size
Swimming Pool
Located at the foot of the Rock, in a sea front building, offering quality fixtures and fittings and with a communal swimming pool and a caretaker's lodge. This large 2 bedroom renovated apartment ha...
2 bedroom Apartment in Golden Square, North East Monaco for sale with 20m2 terrace - 4,900,000 EUR
Apartment in Golden Square
2 bathrooms
123 sqm (1323.48 sq ft) floor size
Set in a residential modern building, situated in the heart of the Golden Square, an amazing location, just a short stroll from the beach and Casino. Completely refurbished in a contemporary style, b...
3 bedroom Apartment in Fontvieille, South West Monaco for sale with 371m2 of land - 35,000,000 EUR
Apartment in Fontvieille
3 bathrooms
277 sqm (2980.52 sq ft) floor size
Swimming Pool
This recently completed, most desirable duplex property is to be found in the district of Fontvieille, with fabulous views over the principality and the sea and private swimming pool on the roof. T...
3 bedroom Apartment in Fontvieille, South West Monaco for sale with 110m2 of land - 24,000,000 EUR
Apartment in Fontvieille
382 sqm (4110.32 sq ft) floor size
Swimming Pool
High-end development recently completed. Located with great sea views in the district of Fontvieille, the residence offers services with luxury and prestige such as swimming pool, fitness centre and g...
3 bedroom Apartment in Carre d'Or, North East Monaco for sale - 22,000,000 EUR
Apartment in Carre d'Or
289 sqm (3109.64 sq ft) floor size
Modern building with concierge located at the heart of Monte Carlo, moments from the Casino Square, beautifully presented and with quality finishings. Beautiful apartment, completely renovated wi...
3 bedroom Apartment in Fontvieille Marina, South West Monaco for sale with 80m2 of land - 16,250,000 EUR
Apartment in Fontvieille Marina
3 bathrooms
331 sqm (3561.56 sq ft) floor size
Swimming Pool
PRICE REDUCED - Highly desirable building with direct frontage onto the Fontvieille Marina. The residence offers services of very great luxury including swimming pool, fitness centre, gardens and 24 h...
4 bedroom Apartment in Larvotto, North East Monaco for sale with 50m2 of land - 13,700,000 EUR
Apartment in Larvotto
3 bathrooms
220 sqm (2367.2 sq ft) floor size
A beautiful and spacious duplex apartment in the Larvotto district of Monaco. Modern and attractive residence with caretaker, located near to the beaches just a row ck from the sea front. Facing th...
2 bedroom Apartment in Close to Casino, North East Monaco for sale with 43m2 terrace - 13,500,000 EUR
Apartment in Close to Casino
1 bathrooms
120 sqm (1291.2 sq ft) floor size
Swimming Pool
PRICE REDUCED - Highly sought-after building ideally located inbetween the waterfront and the Casino Terraces, next to the yacht club and with 24h concierge service, indoor swimming pool (outdoor in ...
2 bedroom Penthouse in Monte Carlo, North East Monaco for sale with 125m2 terrace - 12,500,000 EUR
Penthouse in Monte Carlo
2 bathrooms
296 sqm (3184.96 sq ft) floor size
This property is full of style and charm. Located in a prestigious residence in a sought-after area. This is a gorgeous duplex penthouse apartment (to be renovated) and offers great potential. Roo...
Get In Touch About Monaco Property For Sale
For over 15 years, we have helped thousands of buyers. We can help you find your dream property in Monaco. Our service is completely free, professional, discrete and with no obligation.
Latest Properties
RSS Feed
Keep up to date with the latest properties added to our website.
Our company and properties regularly appear in publications around the world. Click here to view some recent articles.


text:
Welcome to JAS Forwarding USA!
JAS Forwarding (USA), Inc. Corporate Headquarters is located in Atlanta, GA with Branch offices in 23 cities across the USA. Over 450 dedicated team members are supporting any transportation need you may have.
We take care of our customer's transportation from door-to-door, Imports & Exports via Air and Ocean Freight. We offer consolidation services as well as Full Container loads, Ship and Aircraft chartering and the following auxiliary services;
Our office in Houston is dedicated to Projects, Oil & Gas.. We also have dedicated staff looking after our Government Logistics and Live Animal Forwarding divisions.
Please contact one of our Branch offices near you for more information. You'd be surprised what we can do for you!
JAS Forwarding USA Careers
Brazil/USA Trade Lane Newsletter Stories
Compliance Newsletter Blog
JAS Joins in Nepal Relief Effort
Now, at a time when Nepal is in dire need of tangible resources, JAS is there to help meet the immediate needs of the Nepalese people.
4G Technology Moved by JAS
JAS Argentina helps Telecom bring 4G technology to Argentina
JAS Opens New Office in Lima
JAS announces the grand opening of its new Lima, Peru office!
Marciello on the podium in GP2 Series Race in Monaco
JAS Forwarding Worldwide continues in its support of the GP2 race team of Raffaele Marciello.
Phone: +1 (770) 688-1240
Fax: +1 (770) 688-1233