text:
Local teen tells his — and sister's — survival story
Gulf Coast High senior Greg Lang and sister Kaitlyn, a freshman, were both stricken with cancer at a young age while suffering from a rare inherited condition redisposing them to the disease.
Ann Lang looked up from the fries and the gutted Happy Meal baggies, just in time to see the boy bound into his mother's arms.
Kids don't run from plastic rainbows that quickly unless something scares them.
She knew exactly what it was, too, even before his voice sailed over the ball pit and the spring- loaded Fry Guy saddles.
Mommy, Mommy. There's a boy in there and his leg's all broken off.
She'd seen and heard this scene before, of course, and it always ended the same way — the fear gives way to curiosity; curiosity to acceptance; and, in some cases, acceptance to friendship.
Whether this was one of those cases, the plastic Ronald presiding over the scene as it played out many years ago in Rochester, Minn., didn't matter.
There was an opportunity to change a life there, whether the Langs ever happened upon this boy during their regular play time away from the Mayo Clinic down the street or not.
"So I got up from the table, walked over to his parents and said, 'I'm really sorry. I hope we didn't scare your son,' " Lang remembers. "She said, 'No, he needs to understand.' So I said, 'Is it OK if my son comes over, shows it to him and explains it to him?' "
A few feet away, Greg hears this retelling and lets out a giggle.
"He sat there," Ann says, "showed him his stump, how his leg came on and off. The boy was scared at first, but as soon as it was explained ..."
• • •
Scenes like this haven't been uncommon, not for Ann — who started building what she calls "a puzzle" of cancer education with tiny pieces like that one almost 15 years ago — or the son whose life changed forever with a pain in his right foot.
Greg was diagnosed with a type of muscle cancer on Sept. 13, 1992, when he was just 3 years old.
Four months later, the leg was amputated below the knee, and ever since, his mother has encouraged him to tell his story to anyone who cares to listen.
"It's extremely important to speak to other people so that they understand," she'd tell him. "It's not their fault that they don't. Maybe some of them haven't been exposed to this."
So there was the time in the McDonald's.
Or when he'd do the balloon bop on one leg better than the kindergarten classmates who had two.
Then there was that day in his doctor's office, just a year after his amputation, when a 4-year-old Greg ran circles around an 18-year-old about to have the same surgery yelling, "Look at what you'll still be able to do!"
It wasn't always the way it was on Thursday night, though, when the pair told their story to a room of 350, some of them famous faces, at the Pro-Am awards banquet at the Merrill Lynch Shootout.
Greg, always so quick to make friends one-on-one, had become a typical teenager, not-so-fond of public speaking but even less so when his subject matter is one in which no one in the audience can relate.
Only the young man — who at one point grew so tired of telling his story that he jokingly told kids he was a shark attack victim — wouldn't miss this chance for the world.
Not after the past year.
"I don't know how to explain it," he said, "but now I know that I need to say what I need to say."
• • •
Greg said it was "probably the best night of my life," sharing 17 years in two minutes with his mom, then floating on a standing ovation back to the table where Brianna, his girlfriend of one month and one day, sat waiting to extend the warmest hand of all.
"It was a feeling of, 'I can't believe I'm here,' " he said of a speech that ended with handshakes, pats on the back and well wishes. "It was such a big honor to be up there, talking to all these people. It was different because of who was there and the number, but I tried to treat it the same as I would if I was talking to someone one-on-one."
It helped, too, that his younger sister, Kaitlyn, stood by him, too nervous to speak but still standing on the stage she turned red at the thought of just a few hours earlier.
Greg and Ann said there was never a doubt she'd be there, though, right next to the brother who was there for her and "the amazing person" to whom she returned the favor.
"He's really strong," the 14-year-old said, "and we'll always help each other."
It was in that vein, the big- brotherly instincts that took over at an instant, that allowed Greg the strength to tell his sister she had cancer.
"I felt I should explain to her what was going on," Greg said of May 17, 2000, when an 11-year-old heard his mother weep through the doctor's door and delivered the news he knew his parents couldn't. "My mom and dad weren't in a good place to say something."
The diagnosis was, of course, devastating for Ann, but it wasn't completely unexpected.
Greg and Kaitlyn's biological father died of a brain tumor in 2001, and shortly after he was diagnosed five years earlier, Ann's research led her to a rare inherited condition called Li-Fraumeni Syndrome, which affects a cancer-suppressing gene and predisposes young patients to varieties of the disease.
"We have half the barrier," Greg said of a condition that affects fewer than 400 families worldwide. "Half the protection."
But even after Greg's amputation, then the bittersweet pride that came with watching the brother help his little sister through leukemia, Ann found herself "in a fog" again last fall.
Since learning of the Li-Fraumeni Syndrome, she had naturally become a cautious mother.
Everything from small aches and pains to serious colds warranted a checkup, which made the news she received on Sept. 8, 2005 that much tougher to swallow.
Greg was not only diagnosed with colorectal cancer, but with an aggressive stage IV strain that, in spite of the Lang family's precaution, had metastasized to his liver.
He had an eight-hour surgery to remove half of the liver and the tumor on his colon — a procedure doctors told Ann they would have never even attempted on someone older than a teenager — and a handful of smaller surgeries, including the insertion and removal of a tube that stayed in his chest for three months. He sat in a hospital bed for six weeks with massive infections, losing 50 pounds before he finished six weeks of chemotherapy exactly 13 years to the day he finished a four-month treatment for the cancer in his foot.
Kaitlyn was there the whole time.
"Last year at this time, he was lying in a hospital bed," Ann said. "We just didn't know if he'd be here right now, and to see him on a podium speaking to such prominent people? It was ... surreal."
• • •
That surreal night was made possible through the Shootout's partnership with CureSearch National Childhood Cancer Foundation, which for 20 years has partnered with tournament host Greg Norman in raising funds for pediatric research.
Every year since the event relocated to Naples in 2001, CureSearch has selected a local survivor to share his or her story during the awards dinner, and doctors from The Children's Hospital of Southwest Florida suggested Greg and Kaitlyn as this year's ambassadors.
The fact that Greg had adopted golf — first through lessons on the east coast of the state, where the family lived for a time before moving to Minnesota, then through Ann's husband, Tim, a "golf fanatic" she married in 2004 and who legally adopted the children shortly after — as his outlet only made the selection seem more appropriate.
"It was the best way to connect the cause and to really explain to people what this tournament is all about," said Shootout director Taylor Ives. "I think to be told a story like Greg's, it means a lot for people to see. It's a very uplifting story, but it makes you realize there are many out there that don't have the happy ending that Greg's does.
The Pro-Am Awards typically conclude with the auctioning of the 30 pin flags, each autographed by the entire Shootout field, with the proceeds benefiting CureSearch.
Ives said Thursday's contributions were the most in the event's history.
"It was very moving for everyone," Ives said. "They did a great job, and fortunately there were many generous people in the room who were able to make a difference."
• • •
Tweak swears she'll finish the book, even if the rest of the family meets this assertion with grins and eye rolls.
Ann earned the affectionate nickname from Tim and the kids for the book she's been working on — their story — for the better part of five years.
She says she's about halfway through, but there have been constant rewrites.
"I keep getting stuck because I want it to be an inspiration," she says. "So many people that hear our story, they're sad, they're overwhelmed. But we don't look at our life as a tragedy. We look at it as a challenge. That's what's taking me so long. I'll write something and say, 'That sounds sad.' So I'll rewrite it."
Now she's got a new idea for her opening chapter, though.
Her son and daughter, the three of them on stage while the men Tim watches religiously on The Golf Channel dab at their eyes in amazement.
You can change lives in two minutes, you know.
But then, that's nothing new to Greg, now a healthy Gulf Coast senior who's thinking about studying engineering or architecture at college, or Kaitlyn, a freshman who plays clarinet on the school band.
"When there's actually a survivor there, you see the person in front of you, it's a really eye-opening experience," Greg said. "It was unbelievable. I remember a year ago, really not that long ago, and I wasn't doing too good. (Thursday) I was on stage, healthy, and I was just really glad to be there."
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4 Tips to Help You Overcome Envy
4 Tips to Help You Overcome Envy
We all feel it sometimes - pangs of jealousy or envy when we witness others succeed while we feel we are stuck left behind. Whether it is resentment that builds from watching a co-worker score a new position you have been vying for, or feelings of envy for someone who has a family or relationship situation you desire, these feelings are common and you are not alone.
Envy is hard to rid yourself of because the true face of the emotion reveals something about your life that you wish were different - that you would like to change. But, we become stuck and we fear this change. We often don't even realize that we are jealous of another but simply keep this person at a distance or gossip about them behind their backs.
If we wish to truly succeed at accomplishing our own desires and dreams we must put an end to the envy and jealousy. Read on to learn four tips to help you overcome envy.
Heidi Oran is the founder of The Conscious Perspective, a blog providing education and awareness about Personal Growth, Spirituality, and Humanitarian issues. You can visit The Conscious Perspective here, and connect with Heidi via Facebook, or Twitter.
Is Technology Making Us Bible Illiterate?We can't deny there's a major Biblical literacy problem. Is technology to blame?...
What is the Great American Smokeout?An estimated 42.1 million American adults smoke cigarettes with over 400,000...
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Targeting Tumor Microenvironment with Radiolabeled Inhibitors of Seprase (FAPalph
Award Information
Small Business Information
Principal Investigator:
(617) 732-6627
(617) 732-6627
Business Contact:
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Research Institution:
AbstractDESCRIPTION (provided by applicant): The American Cancer Society estimates that in 2008 there will be more than 1.4 million new cases of cancer in the United States and that it will claim the lives of more than 500,000 Americans. The vast majority of t hese cases will be solid tumors, and overt metastatic disease will be present in many of these patients over the course of their disease. The expression of distinct proteins on the surface of tumor cells offers the opportunity to diagnose and characterize disease by probing the phenotypic identity and biochemical composition of the tumor. Radioactive molecules that selectively bind to specific tumor cell surface proteins allow the use of noninvasive imaging techniques, such as molecular imaging or nuclear m edicine, for detecting the presence and quantity of tumor associated proteins, thereby providing vital information related to the diagnosis and extent of disease, prognosis and therapeutic management options. In addition, as radiopharmaceuticals can be pre pared that are not only capable of imaging disease but also delivering a therapeutic radionuclide to the diseased tissue, cancer therapy may be realized. The goal of this proposal is to develop a series of novel techenium-99m (99mTc) based molecular imagin g pharmaceuticals that target the cell surface protein, seprase (FAP1) for imaging by single photon emission computed tomography (SPECT). The expression of seprase is normally restricted to fetal mesenchymal tissue and sites of wound healing, but is select ively overexpressed in cancer-associated fibroblasts in greater than 90% of human primary epithelial tumors including breast, lung, colorectal, gastric, cervical and ovarian cancers, making it an attractive target to exploit for noninvasive imaging as well as targeted radiotherapy. Since stromal support, and therefore seprase involvement, is critical to the initiation of metastatic growth, seprase expression will serve as a molecular marker to detect tumor metastases based on a cancer specific biochemical e vent at an early stage of development. The research plan combines high affinity targeting molecules with the conjugation of a chelator for coordination of a diagnostic or therapeutic radionuclide. Analogs of seprase inhibitors will be synthesized first as non- radiolabeled rhenium complexed molecules and tested to verify binding to seprase in biochemical and cellular assays. Compounds demonstrating high affinity binding to seprase will then be radiolabeled with 99mTc and examined for cell binding, and tumor uptake and retention in mice bearing human cancer xenografts. As seprase is a cell surface protein, the target will be readily accessible, with a straightforward pharmacokinetic analysis. The use of 99mTc will lead to widespread application through kit pr eparation and the prevalence of SPECT scanners in medical institutions. We believe that the 99mTc labeled seprase radiotracers could be exploited for the diagnosis, staging, prognosis and potential treatment of patients with solid tumors and metastases. PU BLIC HEALTH RELEVANCE: The American Cancer Society estimates that in 2008 there will be more than 1.4 million new cases of cancer in the United States which will claim the lives of more than 500,000 Americans, and the vast majority of these cases will be s olid tumors with the presence of overt metastases over the course of their disease. The goal of this proposal is to develop a series of novel imaging radiopharmaceuticals targeting seprase, a protein that is normally restricted to fetal expression and site s of wound healing, but is selectively overexpressed in cancer- associated fibroblasts of greater than 90% of human primary epithelial tumors, making it an attractive target to exploit for noninvasive imaging, as well as targeted radiotherapy. We believe t hat the seprase radiotracers could be exploited for the diagnosis, staging, prognosis and potential treatment of patients with solid tumors and metastases.
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In economics, there's a term called demand elasticity. Basically, this term is used to measure the change in demand for an item in response to the change in its price.
When demand drops significantly with a slight change in an item's price, there is said to be great demand elasticity.
Similarly, when demand stays strong even in the face of a significant increase in price, that item is said to have low demand elasticity or to be inelastic.
The Liberty girls' basketball team hit the road on Tuesday for the longest ride of their careers.
In the opening round of the Region 4A-West playoffs, the Lady Minutemen were to travel to Abingdon.
For those of you who don't have the travel bug, Abingdon is located 163 miles from Bedford. That's 326 miles round-trip.
It causes me great sadness to see the great Ernie Banks dragged through the posthumous muck and mire.
"Mister Cub" was a boyhood idol of mine. He was one of the main reasons I continued to like the team, particularly after I'd outgrown my toddler affinity for the bear cub worn on the players' sleeves.
Unfortunately, the dignity with which he carried himself in life has so far eluded him in the afterlife.
When it comes to heaving heavy orbs of iron or to tossing oneself through the air, Bedford County's got it all over the competition.
As evidence, a pair of county athletes took home gold at the 3A-West indoor track and field meet held Monday evening at Liberty University. It had originally been slated for Saturday, but Mother Nature had other plans.
Quannie Blake showed that he is a premier wrestler, taking third place in the 152-pound class at Salem last Friday.
He also showed that he's a lot more than a heckuva wrestler: He's a heckuva man.
It's a wonder to me that Quannie was even able to make it to Salem. You see, his mother, Joyce Ann Blake, passed away on Tuesday. She was but 52 years old.
Quannie, but 17 years old, was left to deal with such a major loss in his life.
I'm hopeful Governor Terry McAuliffe breaks out the veto pen.
And, I'm hoping the governor vetoes what is commonly known as "The Tebow Bill."
This legislation recently passed both houses of the Virginia legislature. As originally passed in the House of Delegates, the law would open the way for homeschooled children across the commonwealth to participate in sports and other extracurricular activities at their local public schools.
Watch out, Christians-burg, Bedford County is hot on your trail.
While the Blue Demons are still, by far, the crème de la crème of Virginia wrestling, locals showed that Bedford County wrestling is on the ascendancy.
Staunton River and Jefferson Forest landed in third place in their respective regional tournaments last weekend.
As the host team for this past Friday's Conference 30 indoor track championship, Heritage could learn a thing or two from Miss Manners.
Looking like anything but a gracious host, Heritage trounced the rest of its conference peers on both sides of the house.
I'm not a small man. Never have been.
True, some may accuse me of having a small heart or a small mind.
But never a small body.
That's why I was stunned when the wife returned from her shopping foray with a packet of tee-shirts for me.
Copyright © 2015
The Bedford Bulletin is your source for local news, sports, events, and information in Bedford County and Bedford, VA and the surrounding area.


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Page 1
Monaldi Arch Chest Dis
2005; 63: 2, 93-100
Smoked Marijuana as a Cause
of Lung Injury
D.P. Tashkin
A number of substances in addition to tobacco
are inhaled for recreational use, including marijua-
na, crack cocaine, heroin, methamphetamine and
phencyclidine. Of these, marijuana is the most
commonly smoked substance, second only to to-
bacco. In the U.S., for example, among high
school seniors, 21.2% admit to smoking marijuana
within the previous month, compared to 24.4% for
tobacco, while 6.0% state that they smoke mari-
juana daily, compared to 14.6% who smoke tobac-
co every day [1]. Marijuana smoke is composed of
qualitatively the same ingredients that are present
in tobacco smoke (e.g., carbon monoxide, cyanide,
acrolein, benzene, vinyl chlorides, aldehydes, phe-
nols, nitrosamines, reactive oxygen species, and a
variety of polycyclic aromatic hydrocarbons [2, 3],
with the major exceptions of the unique presence
of ∆9-tetrahydrocannabinol (THC) and approxi-
mately 60 other cannabinoids only in marijuana [2,
3] and of nicotine only in tobacco. In view of this
similarity in the chemical contents of the smoke
from both substances, it might be expected that ha-
bitual inhalation of the smoke of marijuana might
have injurious effects on the lung that are at least
qualitatively similar to those resulting from regular
tobacco smoking. Such tobacco-related pulmonary
consequences are well-documented and include
chronic obstructive pulmonary disease, bron-
chogenic carcinoma and an increased predisposi-
tion to lower respiratory tract infection. This report
will review the evidence that addresses the ques-
tion whether habitual smoking of marijuana can
lead to long-term pulmonary effects similar to
those of tobacco.
Comparative acute effects of marijuana and tobacco
on lung function
Unlike tobacco, which causes modest, tran-
sient reflex-mediated bronchoconstriction, smoked
marijuana causes acute bronchodilation both in
healthy individuals [4] and asthmatic subjects [5]
and rapidly reverses both exercise- and metha-
choline-induced bronchoconstriction in subjects
with asthma [6]. The bronchodilator effect of mar-
ijuana is dependent on the concentration of ∆9-
tetrahydrocannabinol (THC) and can be repro-
duced with oral THC in a dose-dependent manner
[4]. The mechanism of THC-induced bronchodila-
tion appears to be due to inhibition of acetyl-
choline release from efferent post-ganglionic
nerve fibers that innervate airway smooth muscle,
by analogy with the relaxant effect of THC on
guinea pig ileum and inhibition by THC of sali-
vary gland secretion in dogs [7-9]. Recently,
cannabinoid type 1 (CB1) receptors (that mediate
Keywords: Marijuana, cannabis, respiratory symptoms, lung function, lung injury, alveolar macrophages, respiratory cancer.
Correspondence: Donald P. Tashkin, M.D.; Professor of Medicine; Division of Pulmonary & Critical Care Medicine; Department
of Medicine; David Geffen School of Medicine at UCLA; Los Angeles, CA 90095-1690; U.S.A.; e-mail email@example.com
ABSTRACT: Smoked Marijuana as a Cause of Lung Injury.
D.P. Tashkin.
In many societies, marijuana is the second most com-
monly smoked substance after tobacco. While ∆9-tetrahy-
drocannabinol (THC) is unique to marijuana and nicotine
to tobacco, the smoke of marijuana, like that of tobacco,
consists of a toxic mixture of gases and particulates, many
of which are known to be harmful to the lung. Although far
fewer marijuana than tobacco cigarettes are generally
smoked on a daily basis, the pulmonary consequences of
marijuana smoking may be magnified by the greater depo-
sition of smoke particulates in the lung due to the differing
manner in which marijuana is smoked. Whereas THC
causes modest short-term bronchodilation, regular mari-
juana smoking produces a number of long-term pul-
monary consequences, including chronic cough and spu-
tum, histopathologic evidence of widespread airway in-
flammation and injury and immunohistochemical evidence
of dysregulated growth of respiratory epithelial cells, that
may be precursors to lung cancer. The THC in marijuana
could contribute to some of these injurious changes
through its ability to augment oxidative stress, cause mito-
chondrial dysfunction, and inhibit apoptosis. On the other
hand, physiologic, clinical or epidemiologic evidence that
marijuana smoking may lead to chronic obstructive pul-
monary disease or respiratory cancer is limited and incon-
sistent. Habitual use of marijuana is also associated with
abnormalities in the structure and function of alveolar
macrophages, including impairment in microbial phagocy-
tosis and killing that is associated with defective production
of immunostimulatory cytokines and nitric oxide, thereby
potentially predisposing to pulmonary infection. In view of
the growing interest in medicinal marijuana, further epi-
demiologic studies are needed to clarify the true risks of
regular marijuana smoking on respiratory health.
Monaldi Arch Chest Dis 2005; 63: 2, 93-100.
Page 2
the neural effects of THC) were found on axon ter-
minals of post-ganglionic parasympathetic nerve
fibers in rat lung in close proximity to airway
smooth muscle [10]. Stimulation of similar recep-
tors in the guinea pig airway by the endogenous
cannabinoid, anandamide, resulted in dose-depen-
dent relaxation of capsaicin-contracted airway
smooth muscle, suggesting that the endogenous
cannabinoid system may play a regulatory role in
the control of airway smooth muscle tone and pro-
viding an explanation for the bronchodilator effect
of exogenous THC.
From a clinical perspective, on the other hand,
smoking marijuana does not have a therapeutic
role in obstructive airways diseases such as asthma
since, despite its short-term bronchodilator proper-
ties, the long-term pulmonary consequences of
marijuana smoking include several undesirable
features, such as airway inflammation, edema and
mucus hypersecretion, as described below.
Long-term effects of habitual marijuana smoking
Effects on respiratory symptoms
Respiratory symptoms were assessed using a
standardized respiratory questionnaire [11] admin-
istered to a convenience sample of residents of Los
Angeles, including 144 heavy, habitual smokers of
marijuana only (MS), 135 regular smokers of both
marijuana and tobacco (MTS), 97 control non-
smokers (NS) and 79 smokers of tobacco only
(TS). On average, MS had smoked ~3-4 marijuana
cigarettes ("joints") per day for >10 years, while
TS had smoked >20 tobacco cigarettes per day for
>10 years. Of these subjects, 18-19% of MS ad-
mitted to chronic cough and sputum production,
compared to 2-5% of NS, 24% of MS experienced
wheeze on ≥21 days a year compared to 7% of NS,
and 13% of MS but only 2% of NS had ≥2
episodes of acute bronchitis within the preceding 3
years [11]. The differences in occurrence of these
respiratory symptoms between MS and NS was
statistically significant (p<0.05). While TS and
MTS had a slightly higher prevalence than MS of
similar symptoms, differences from MS were not
statistically significant. These findings indicate
that regular smoking of marijuana, even in the ab-
sence of tobacco, can lead to chronic bronchitis
and a tendency to acute bronchitic episodes to an
extent that is comparable to the effect of tobacco
smoking; on the other hand, additive effects of
marijuana and tobacco on chronic and acute respi-
ratory symptoms were not apparent. Similar find-
ings have been reported by other investigators in a
randomly stratified population-based cohort in
Tucson, Arizona [12] and a birth cohort in
Dunedin, New Zealand [13], except that an addi-
tive effect of marijuana and tobacco was noted in
the Arizona study [12].
Effect on lung function
Three groups of investigators have systemati-
cally examined lung function, both cross-sectional-
ly and longitudinally, in well-characterized cohorts
of habitual marijuana smokers and control non-
smokers of marijuana, controlling for the effects of
tobacco [11-16]. In the Los Angeles cohort, most
physiologic tests, including spirometry, as well as
closing volume and density-dependence of flow in-
dices (sensitive measures of small airways func-
tion) and diffusing capacity (a sensitive but non-
specific physiologic indicator of emphysema),
were within normal limits and not different from
the results in nonsmokers; the only exception was a
slight but statistically significant increase in
plethysmographically measured airway resistance
in the MS, suggesting an impact of marijuana
smoking on the large airways [11]. In addition,
among MS, the annual rate of change in forced ex-
pired volume in 1 sec (FEV1) measured over 8
years was not significantly different from that of
NS [14]. In contrast, TS exhibited significant
decrements compared to control NS in tests of
small airways function cross-sectionally, as well as
a significantly greater annual rate of decline in
FEV1than NS [14]. These findings suggest that
heavy, habitual smoking of marijuana, in the ab-
sence of tobacco, does not produce the early or pro-
gressive physiologic changes that precede the clin-
ical development of chronic obstructive pulmonary
disease (COPD). These results are also consistent
with findings in rats involving exposure to increas-
ing concentrations of marijuana or tobacco smoke
over one year that led to morphologic and physio-
logic changes of emphysema (decreased alveolar
surface area and reduced lung elastic recoil) only in
the tobacco-exposed rats but not in the animals ex-
posed to a similar quantity of marijuana [17].
On the other hand, two other studies involving
the cohorts from Tucson and Dunedin revealed ev-
idence of mild airflow obstruction in association
with marijuana use [12, 13]. Moreover, in both of
these cohorts the airflow obstruction progressed
over time in the continuing marijuana users [15,
16]. In contrast to the Los Angeles study, there-
fore, these two reports suggest that regular use of
marijuana may be a risk factor for the subsequent
development of COPD. Further research is re-
quired to resolve these conflicting findings.
Effects on visual evidence of airway injury and
bronchial mucosal histopathology
A subset of MS, MTS, TS and NS from the
Los Angeles cohort underwent fiberoptic bron-
choscopy, including videotaping of the tracheo-
bronchial mucosa and/or performance of a series
of mucosal biopsies [18]. The videotapes were
blindly scored for the presence and degree of air-
way injury using a semiquantitative scoring sys-
tem for mucosal erythema, swelling and increased
secretions ("bronchitis index"). Visual evidence of
airway injury of comparable degree was noted in
both the MS and the TS with scores significantly
higher than in control NS [18]. Mucosal biopsies
from these same subjects revealed histopathologic
abnormalities corresponding to the visual endo-
scopic changes of erythema, edema and increased
Page 3
secretions, including increased number and size of
submucosal blood vessels, submucosal edema and
hyperplasia of the mucus-secreting surface epithe-
lial cells (goblet cells).
Light microscopy of bronchial mucosal biop-
sies in 40 MS, 31 TS, 44 MTS and 53 NS [19] re-
vealed extensive histopathologic alterations in the
epithelium of the MS, including goblet cell hyper-
plasia, reserve cell hyperplasia, squamous meta-
plasia, cellular disorganization, nuclear atypia, in-
creased mitotic index, increased nuclear/cytoplas-
mic ratio and inflammatory changes. The frequen-
cy of these abnormalities in the MS was compara-
ble to that noted in the TS, with the suggestion of
additive changes due to regular use of both sub-
stances in the MTS. Some of these histopatholog-
ic changes have been associated with the subse-
quent development of bronchogenic carcinoma in
tobacco smokers [20].
Bronchial biopsies from 52 of these subjects
were examined using immunohistology to detect
abnormal expression of genes involved in the
pathogenesis of lung cancer, including epidermal
growth factor receptor (EGFR), increased expres-
sion of which can promote autonomous cell
growth, and Ki-67, a nuclear proliferation protein
involved in cell replication [21]. Findings revealed
striking overexpression of EGFR and Ki-67 in MS
compared to NS, numerically even greater expres-
sion in MS than TS and the suggestion of additive
effects in MTS. The light microscopic and im-
munohistochemical findings, when considered to-
gether, suggest that regular marijuana smoking in-
jures the airway epithelium leading to dysregula-
tion of bronchial epithelial cell growth and poten-
tially to malignant transformation.
The similarity between the frequency, type and
extent of the endoscopic and histopathologic evi-
dence of injury in the large central airways of the
smokers of marijuana alone and those of tobacco
alone contrasts strikingly with the marked differ-
ence in the number of cigarettes smoked for the two
types of substances (approximately 3-4 joints per
day in the MS versus 22 tobacco cigarettes per day
in the TS). This disparity could be due partly to the
four-fold greater quantity of marijuana smoke par-
ticulates (tar) deposited in the respiratory tract
compared to the deposition of tar generated from
the same amount of smoked tobacco, thereby like-
ly magnifying the impact of smoked marijuana on
the lung. This difference in respiratory deposition
of marijuana vs. tobacco tar has been attributed to
differences in the way the two plant substances are
smoked (e.g., four-fold longer breathholding time
during marijuana than tobacco smoking) [22, 23].
A possible additional explanation for the similar
impact of much smaller smoked quantities of daily
marijuana than tobacco on respiratory symptoms
and bronchial mucosal histopathology is that the
THC and other cannabinoids unique to marijuana
smoke might themselves have toxic effects that
serve as an independent contributing factor to the
changes observed in the large central airways. On
the other hand, although possible structural
changes in the distal lung could not be assessed
bronchoscopically, results of the physiologic stud-
ies noted above suggest markedly different effects
of tobacco and marijuana, i.e., evidence of small
airways dysfunction and gas transfer abnormality
in relation to tobacco and the absence of any simi-
lar abnormality in relation to marijuana. The rea-
sons for these two different types of disparate ef-
fects of the two different plant substances on large
airways vs. the distal lung are unclear but point to
the possibility of contrasting effects of THC (and
possibly other cannabinoids) on the biology of the
epithelial cells in large vs. small airways that war-
rants further study.
Effects on alveolar macrophages
Alveolar macrophages (AM) are the primary
immune cells residing in the distal air spaces of the
lung and serve a critical role in host defense
against infection, other noxious insults and malig-
nancy. AM, recovered by bronchoalveolar lavage
(BAL) at the time of bronchoscopy in participants
in the Los Angeles study, were enumerated and ex-
amined for structural and functional changes [24].
Approximately 2, 3 and 4 times as many AM were
recovered from MS, TS and MTS, respectively,
than from NS, indicating an additive effect of mar-
ijuana and tobacco on AM accumulation [24]. The
accumulation of AM in the lungs of MS probably
represents an inflammatory response to noxious
components, including oxyradicals, within the
smoke, resulting in either increased AM recruit-
ment to and/or increased replication in the lung.
On ultrastructural examination, AM from MS as
well as TS revealed large irregular-shaped cyto-
plasmic inclusions, most likely containing particu-
lates taken up by these cells from the inhaled mar-
ijuana or tobacco tar; the number of these inclu-
sions was dramatically increased in smokers of
both marijuana and tobacco [25]. The presence of
large numbers of abnormal inclusion bodies with-
in the cytoplasm of AM from smokers of marijua-
na and/or tobacco might interfere with the function
of these important immune effector cells.
Several aspects of the function of AM recov-
ered from the aforementioned nonsmokers and
smokers or marijuana and/or tobacco were evalu-
ated: 1) phagocytic and killing activity against fun-
gi and bacteria; 2) production of reactive oxygen
and nitrogen intermediates during incubation with
fungi or bacteria; 3) ability to produce proinflam-
matory cytokines when stimulated; and 4) cytotox-
ic activity against tumor cell targets. Significant
findings from these studies of AM function may be
summarized as follows:
Impairment in fungicidal activity against Can-
dida albicans and Candida tropicalis when
AM from both MS and TS were compared to
AM from control NS [26, 27];
Impairment in phagocytosis and bactericidal
activity against S. aureus by AM from MS but
not TS [27];
Reduction in basal superoxide production by AM
from MS (contrasting with an increase in basal
superoxide generation by AM from TS) [26];
Page 4
Impairment in generation of nitric oxide by
AM from MS (but not TS), paralleling their
impairment in bactericidal activity [28];
Reduction in generation of proinflammatory
cytokines, including TNF-alpha (TNF-α) and
granulocyte macrophage-colony stimulating
factor (GM-CSF), by AM from MS when stim-
ulated with bacterial lipopolysaccharide [27];
Impairment in tumoricidal activity by AM
from MS [27].
It is likely that THC, which is present only in
the tar from marijuana smoke, is responsible for
the functional differences noted between AM from
MS vs. TS. One of the important clinical implica-
tions of the striking impairment in the function of
AM from MS, particularly with regard to microbi-
cidal activity, is that habitual smokers of marijua-
na may be at greater than normal risk for develop-
ment of pneumonia. This possibility has been sug-
gested by the results of a few epidemiologic stud-
ies (see below)
The defect in the bactericidal activity of AMs
from MS appears to be due to THC-related im-
pairment in production of nitric oxide, a reactive
nitrogen intermediate that serves as an important
effector molecule in bacterial killing. This hypoth-
esis is supported by the finding that inhibition of
nitric oxide synthase impairs killing of S. aureus
by AMs from nonsmokers and tobacco smokers,
but not by AMs from marijuana-only smokers
[27]. More recent data have shown an inhibition of
production of inducible nitric oxide synthase (iN-
OS) by AMs from marijuana smokers under con-
ditions of the S. aureus killing assay that was re-
stored by the addition of pro-inflammatory cy-
tokines (e.g., INFγ and GM-CSF) [28]; under the
latter conditions, NO production and killing could
be inhibited in the presence of an iNOS inhibitor,
as shown with AMs from nonsmokers in bacterial
culture [27, 28]. These findings suggest that the
impairment in the bactericidal activity of AMs
from marijuana smokers might be due to marijua-
na-related inhibition of microbially-stimulated
production of key pro-inflammatory cytokines that
are needed, in turn, to induce iNOS. This hypothe-
sis is further supported by other findings indicating
that lipopolysaccharide-stimulated production of
TNF-α, IL-6 and GM-CSF is inhibited by AMs
from MS but not from TS [27].
Clinical implications of marijuana-related
impairment in alveolar macrophage function
The clinical implications of the above findings
are that regular marijuana smoking may compro-
mise the lung's defense against infection by im-
pairing the crucially important antimicrobial func-
tion of alveolar macrophages through inhibition of
the production of pro-inflammatory cytokines that
are required for immune activation. This possibili-
ty is supported by previous case reports of invasive
Aspergillus pneumonia in immunocompromised
patients with AIDS [29], chronic granulomatous
disease [30], bone marrow transplantation [31], re-
nal transplantation [32] or small cell lung cancer
treated with chemotherapy [33], all of whom
smoked marijuana. On the other hand, these cases
of invasive pulmonary aspergillosis could be due
primarily to the immune compromise from their
underlying disease and/or the fact that marijuana is
frequently contaminated with Aspergillus fumiga-
tus [34], although a superimposed THC-related
impairment of pulmonary host defenses could be
an important additive factor predisposing to op-
portunistic infection. Marijuana has also been
shown to be contaminated with potentially patho-
genic gram-negative bacteria [35] that could simi-
larly lead to pneumonia, especially in the setting of
a compromised immune system.
As additional evidence of a link between regu-
lar marijuana use and infectious complications in
immunocompromised patients, a few older epi-
demiologic studies have identified marijuana as a
significant independent risk factor for the develop-
ment of opportunistic pulmonary infection in
HIV+ individuals [36-38]. In view of the increas-
ing interest in medicinal marijuana, the possibility
that marijuana smoking may predispose HIV+ pa-
tients to pneumonia requires further investigation
by more rigorous epidemiologic studies.
Does marijuana smoking predispose to respiratory
Smoke contents of marijuana; cellular, tissue, and
human studies
That marijuana smoking may be a risk factor
for respiratory cancer is suggested by the chemical
composition of marijuana smoke, as well as by ev-
idence from cellular, tissue, animal and human
First, marijuana smoke contains several of the
same carcinogens and co-carcinogens as tobacco
smoke, including vinyl chorides, phenols, ni-
trosamines, reactive oxygen species and various
polycyclic aromatic hydrocarbons (PAHs) [3].
Furthermore, benzo[α]pyrene, a highly procar-
cinogenic PAH, is present in marijuana tar at a
higher concentration than in tobacco tar [2, 3].
Second, because of differences in the manner
in which marijuana and tobacco are smoked,
~4-fold more of the tar from marijuana smoke than
that from tobacco is deposited in the respiratory
tract [22], thereby magnifying the level of expo-
sure to carcinogens from each marijuana cigarette.
Third, hamster lung explants exposed to mari-
juana smoke for ≤ 2 years developed abnormal cell
growth and accelerated malignant transformation,
changes that were even more prominent than those
noted in explants exposed to tobacco [39].
Fourth, bronchial biopsies from heavy, habitu-
al smokers of marijuana alone showed 1) light mi-
croscopic changes of epithelial hyperplasia, meta-
plasia and nuclear atypia that have been associated
with the subsequent development of bronchogenic
carcinoma in tobacco smokers [19, 20] and 2) im-
munohistochemical overexpression of Ki-67 (a
proliferation marker), EGFR (epidermal growth
Page 5
factor receptor) and DNA ploidy (a marker of ge-
netic instability), consistent with dysregulated
growth and pre-tumor progression [21].
Fifth, in vitro exposure of endothelial cells
(ECV 304 cell line), transformed lung cells (A549
cell line) and primary human airway epithelial
cells to smoke from marijuana cigarettes stimulat-
ed the formation of more reactive oxygen species
(ROS) than did exposure to the same amount of to-
bacco smoke and in direct proportion to the con-
centration of THC, indicating that marijuana
smoke is a potent source of oxidative stress that
could lead to cell injury, DNA damage and ulti-
mately malignant transformation [40-44].
Sixth, exposure of pulmonary transformed
A549 cells to tar extract from marijuana cigarettes
or to pure THC is associated with a toxic effect on
mitochondial electron transport, resulting in
adenosine triphosphate (ATP) depletion [44]; the
resulting mitochondrial function dysfunction
could lead to inhibition of apoptosis, as has also
been demonstrated following exposure of A549
cells to marijuana smoke extract [41], which, in
turn, could play a role in carcinogenesis.
Animal studies
Non-small cell lung cancer cell lines implanted
into immunocompetent mice displayed accelerated
growth in the animals given THC intraperitoneally
compared to control animals given vehicle alone
[45]. Tissue assays from the tumors and spleens re-
sected from THC-treated mice showed over-produc-
tion of immunosuppressive cytokines (IL-10 and
TGF-β) and underproduction of immunostimulatory
cytokines (IL-2 and INF-γ) compared to control
mice. The latter findings are consistent with a bias-
ing effect of THC on T helper cell-type 1/T helper
cell-type 2 (Th1/Th2) balance toward Th2 cells, as
has been suggested by the results of other studies
[46-48]. The augmentation of tumor cell growth by
THC was blocked by co-administration of a selec-
tive antagonist against CB2 receptors (which are ex-
pressed primarily on immune cells). Thus, THC ac-
celerates tumor growth in vivo by a cytokine-depen-
dent and CB2 receptor-mediated mechanism that
impairs the development of anti-tumor immunity.
Clinical case series
That marijuana may be a risk factor for respi-
ratory cancer is further suggested by several small
case series that reported an unusually high propor-
tion of marijuana smokers among young individu-
als (< age 40-45 years) in whom upper aerodiges-
tive tract cancers [49-52] or lung cancer [53] were
diagnosed. However, case series do not provide
strong evidence of a causal association since they
are uncontrolled, indicating the need for well-de-
signed epidemiologic studies.
Epidemiological studies
A few controlled epidemiological studies have
addressed this issue with conflicting results. A
large retrospectively analyzed cohort study of
65,000 subscribers to a Northern California health
maintenance organization failed to find an elevat-
ed risk for tobacco-related malignancy, including
lung and upper airway cancer, among ever or cur-
rent marijuana smokers, after adjustment for to-
bacco smoking [54]. Weaknesses of this study in-
cluded the relatively young age of the participants
at the end of follow-up period and inclusion of few
long-term or heavy marijuana smokers [54].
Two case-control studies that examined
cannabis use as a possible risk factor for lung can-
cer were conducted in North Africa [55, 56]. A
Tunisian study, including 110 lung cancer cases
and 110 controls, reported a markedly elevated OR
for ever use of cannabis (OR=8.2, 95%CI=1.3-
15.5) [55]. Although cannabis is believed to be
used in relatively large amounts in this region, un-
fortunately dose-response relationships were not
assessed in this study. A second lung cancer case-
control study, conducted in Northern Morocco, as-
sessed the association between lung cancer and the
use of hashish and kiff (a powdery preparation
from the dried flowers of the female Cannabis
sativa plant mixed with tobacco), with or without
snuff [56]. Results of this study, which included
118 lung cancer cases and 235 controls, indicated
that the combined use of hashish/kiff and snuff
was associated with a 6.67-fold greater risk [95%
C.I. 1.65-26.90] for developing lung cancer, while
the risk was much lower for the use of hashish/kiff
without snuff (1.93-fold [95% C.I. 0.57-6.58]) and
lower still for the use of snuff only (OR=1.06
[95%CI=0.33-3.47]). Since kiff includes tobacco,
the independent effect of cannabis cannot be as-
sessed in this study.
Three case-control studies on marijuana smok-
ing and risk of upper airway cancer have been pub-
lished [57-59]. The first of these studies was a hos-
pital-based U.S. study that included 173 head and
neck cancer cases and 176 controls; the authors
found that a history of daily or near-daily marijua-
na smoking was associated with a 2.6-fold greater
risk [95% C.I. 1.1-6.6] for developing head and
neck cancer, after adjusting for other known risk
factors, including tobacco smoking and alcohol
use [57]. Furthermore, a dose-response relation-
ship was found, and an even higher risk of mari-
juana smoking for the development of cancer was
noted among younger individuals (< age 55 years).
In contrast, a Washington State population-based
case-control study of 407 cases of squamous cell
cancer and carcinoma in situ of the oral cavity and
615 controls reported no association with marijua-
na use (OR = 0.9, C.I. 0.6-1.3) and no dose-re-
sponse trends for frequency or duration of mari-
juana use [58]. A third head and neck cancer case-
control study among young individuals (≤ 45
years) in the UK, including 116 cases of squamous
cell cancer of the oral cavity and 207 matched con-
trols, failed to find an association between
cannabis use and oral cancer [59]. In the latter
study, however, estimated risks associated with
known major risk factors, namely tobacco and al-
cohol, were low, suggesting that the study may


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Re: Re: Question for those who are gravity filtering...
Ben, your description above is what I use (or have set up anyway). I just put together my system then it came to my attention that some people re-use the tube (tube A) which seems unnecessarily ris...
Question for those who are gravity filtering...
This is actually a slightly more specific question than the subject led on; it will apply to those using a gravity filter (any) and a hydration system. For anyone not using a hydration system, you ...
Re: Re: Yosemite " Epic snow Trip" 2011
Thanks for the info Marc. For some reason I thought you guys were out past Dewey Point. Since seeing them at the OR the Toughstakes look very promising, good to hear of an actual report. Which size...
Re: Yosemite " Epic snow Trip" 2011
I was just taking a look at all of these photos again. Do you guys think putting the blocks around the inside perimeter of your tarps would have kept out the wind driven snow somewhat? Did anyone h...
Re: Favorite Backcountry Music?
I never take music with me, but before a hike anything with banjos, washboards, or steel guitar usually sets the mood... Iron and Wine Ugly Casanova The Devil Makes Three etc...
Re: Speaking of light; wouldn't sharing gear make our packs much lighter?
Sorry to be the one to steer back to the original question, but in my experience I travel slightly lighter when solo. It's a personal thing for me but when I share gear (as I always do when tra...
Re: How important is the weight of trekking poles?
If you're not having any ergonomic issues or otherwise with your current poles it might be difficult to quantify any differences. Having said that, there is a noticeable difference when holding...
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Good to hear everyone made it out safely. From the photos and reports "EPIC" definitely sounds like the perfect summary of the trip. Like others, wishing I was there, but glad I wasn'...
Does it have to be eVent? The EB First Ascent BC-200 is made with their WeatherEdge material. Specs are published and look similar to eVent. Jackets come in tall sizing. http://www.eddiebaue...
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Walker, Texas Ranger: Season 8, Episode 7
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An undercover cop is killed by the crime boss he was investigating. The deaf daughter of an Elvis impersonator saw the murder and is now in danger from the killer.
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Shoot Them Down! - The Flying Saucer Air Wars Of 1952
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During the summer of 1952, Americans reported a record amount of UFO sightings to Project Blue Book. Frank Feschino, Jr. has written a book about the 1952 summer and America's UFO problem. He... More > takes the reader on a journey through Blue Book's "UNKNOWN" cases and other UFO reports. He focuses on the encounters between US. fighter planes and UFOs with an in-depth historical account of the United States military's "shoot down" orders. On Sept. 12, 1952, a horrific encounter occurred in West Virginia when a 12-foot-tall being, the "Flatwoods Monster," terrified a group of Flatwoods residents after it's damaged craft landed in their town. Feschino reports on this case in great detail and has become the authority on the "Flatwoods Monster" incident. For the first time, he writes the complete version of this terrifying alien encounter...the most accurate documentation of this event in print. 90 photos, maps & illustrations.< Less
The Braxton County Monster Updated & Revised Edition The Cover-up of the "Flatwoods Monster" Revealed Expanded
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Frank C. Feschino, Jr., the authority of the "Braxton County Monster" incident has returned with an Updated and Expanded version of his 2012 book. His ongoing and diligent 21-year... More > investigation into this case reveals an invasion of gigantic aliens that occurred over America on September 12, 1952. Feschino meticulously reconstructed a timeline of events and recreated the scenario of that terrifying day, which includes the "Flatwoods Monster" and "Frametown Monster" incidents, a massive wave of UFO sightings and crashes and the cover-up of a USAF jet fighter that disappeared that night. This book contains new documentation about the "Braxton County Monster" case and startling UFO events of that day and includes additional witness information, newly discovered sightings, crashes, landings and more. It contains more than 225 visuals, including new articles, photos, maps, graphics and illustrations, which credit Feschino as the world's most thorough investigator of this UFO incident in history.< Less
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Health Matter: Nightlights, canes, taller furniture can all help prevent falls as we age
Q: I am worried about getting older and breaking a bone or my hip. I know it is more common in women. Is there anything I can do to prevent it? — K.D., Anderson
A: One major concern as we age is osteoporosis. Osteoporosis is defined as a disorder in which the bones become porous and brittle and often break. It is caused by loss of calcium and other minerals in the bones. The U.S. Preventive Services recommends that women older than age 65 and women younger than 65 with a family history of fractures should have a bone-density test. The bone-density test helps to identify osteoporosis and a person's risk for fractures. The information can assist you and your doctor in planning for steps you might take to improve bone density, prevent any bone loss and, if necessary, manage osteoporosis.
The risk factors for osteoporosis include diets that are low in calcium and vitamin D, lack of regular exercise or immobility, body weight (too thin), smoking, alcohol use and certain medications. Of course, there are risk factors that no one can change that may place one at higher risk. Osteoporosis is more common as we age, if we are female of Caucasian or Asian descent and if we have a family history. Because of the age factor, all women and men should be concerned about loss of bone density.
Low bone density is managed through healthy lifestyle changes that include weight-bearing activities such as walking and eating foods rich in calcium and vitamin D. If a person has been diagnosed with osteoporosis, medications are available that slow down and may reverse bone loss.
Falls are a major concern of most people as they age. The risk of falling does increase with age- related changes in our body's strength and balance, eyesight and hearing. Certain diseases such as osteoarthritis, Parkinson's, strokes and dementia can increase our risk of falling. Our choice of footwear also makes a difference. In a 2008 report by Barry and Miller, they cite the increased risk of falls when individuals are on more than three to four medications, and certain individual medications can increase the risk of falls, such as sedatives. Once a person has fallen, they tend to fear falling again. Even when a fall does not result in a broken bone, there might be other injuries that occur that require medical attention. Also noted by Barry and Miller was the greater risk of functional decline and withdrawal after falls.
An important preventive step is to ensure your environment is safe. An essential step is good lighting so you can see where you are walking. Our eyes change as we age. Depth perception might change as well. It is also important to make sure you have nothing on steps or in hallways that you might trip over. That means you might need help to clean and organize your home. Furniture might need to be rearranged to remove pieces you might trip over.
Carpets and area rugs might need no-slip strips or they might need to be tacked in placed. Consider discarding throw rugs. Some people find that chairs and sofas may need to be higher so it is easier to sit down and to get back up. You may find a cane is helpful. Talk with doctor about appropriate exercises to keep you in shape and maintain your balance.
Other considerations include using the handrails when you go up and down stairs, and do not carry things that block your vision from the steps or would require both hands. You might need to use extra care when reaching for items on higher shelves. Nightlights in the bedroom and bathroom are recommended as well. This might help if light switches are not in easy reach when you get up at night. A flashlight by the bed can be helpful as well. Grab bars may be helpful in the bathroom.
If you live alone, you might consider a medical alert system. A cordless phone that you can keep nearby can also be helpful. Cellphones are very helpful as well, if you keep it with you.
Send your health questions to Debbie Jackson, Ph.D., MN, Clemson University, 302 Sikes Hall, Clemson, S.C., 29634-5155 or email firstname.lastname@example.com.
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text:
Figure 7.
Relative gene expression of selected genes during pollen pistil-interaction. Genes are listed by their probe set ID of the Affymetrix Citrus GeneChip and by their tentatively assigned name. A: cit.7568 (F-box); B: cit.11563 (Asp-rich protein gene); C: cit.5456 (Asp-rich protein gene); D: cit.5776 (Asp-rich protein gene). Styles with stigmas were sampled from 0 (non-pollinated flowers) to 8 DAP. Control samples of non-pollinated flowers, collected at 1, 3 and 6 DAP, were added to the time course analysis to determine if the genes were induced by self-pollination. Error bars indicate standard deviations from the mean.
Caruso et al. BMC Plant Biology 2012 12:20 doi:10.1186/1471-2229-12-20


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The Ayrlington
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
- Continental Breakfast
- Free High-Speed Internet
- Bar/lounge
- Free parking
TravelPod Member ReviewsThe Ayrlington Bath
Very nice old building, comfy room and welcoming staff. Being a B&B they only serve breakfast so you have to find lunch and dinner elsewhere but it is very close to City centre so that's not a problem
This review is the subjective opinion of a TravelPod member and not of TravelPod.com.
Historical Traveler Reviews The Ayrlington Bath
Good weekend get away
We stayed for a weekend in February at the Arylington. The room was large and clean. The breakfast was adequate but nothing special. We found the staff to be both friendly and helpful. The location is close to town but also far enough away so that you are not always swamped by tourists. Good place to stay for romantic weekend but a bit pricey.
Great place to stay
A great find, had an excellent stay with great service.
Great stay
this trip was a very special one for us and made all the better by the lovely atmosphere at this hotel.
There were lovely views of the abbey and the gardens were beautiful. We found the staff to be helpful and enthusiastic.
As it was just a short walk into town it was all the better.
The Ayrlington was a perfect place to relax and unwind. Having shopped all day and eaten in a very noisy restaurant, we found our hotel and its surroundings very peaceful. The hotel decor itself is quite sumptuous and we found the staff to be very helpful and polite.
Our room was lovely and the spa bath was very relaxing. We ate a perfectly enjoyable breakfast in a lovely room with fantastic views.
All in all a great weekend.
Dissapointed and disgusted
My husband and I needed a weekend away and spent hours trailing through web sites trying to find the perfect place for the perfect weekend. We chose the Chinese room (a superior room) at the Ayrlington as we had some very happy memories of the Far East and thought it very apt for us. The rooms were not cheap, but we decided to go the extra mile and have a truely special weekend. On arrival we were taken to our room by a very polite and friendly receptionist. As she opened the door, we realised that she had taken us to the wrong room. The room although nice, was a standard room and not what we had asked for. We told her that it was the wrong room. She appologised and led as back to the reception area. We took a seat and waited whilst she got the other key. It transpired that the room had been double booked. We heard the receptionist talking to a member of staff in the background explaining the predicament and he simply replied 'stick them in another room'! I don't think that he realised that we had actually arrived and were within earshot. The receptionist offered us the option of the standard room at a reduced rate or an equivalent superior room for one night but that meant that we would have to move rooms for the second night into a standard room (not something that we really wanted to have to do since we were only staying for two nights). It was at this point that I enquired if the other people who had booked the same room had arrived yet. They had not. I asked her why we couldn't have the room since we had already arrived and had travelled two and a half hours to get there. (please note that we did not want the other guest to be dissapointed about the room either but we had arrived first and were very tired and we had our hopes set on the room). The manager appeared at this point. He said that we could not have the room. We asked him why we couldn't when we were the first to arrive etc and that it was their mistake. He would not give us the room. We felt really discriminated against as he would not give us an acceptable reason why he was allowing the other guest to have the room over us. He was extremely patronising in his manner and very unhelpful. He could not understand that this was supposed to be our dream weekend and that we really wanted that particular room. We have the proof in black and white that the room is booked but he was not going to help or budge on his decision. He did offer to find as another hotel, but as you can imagine we were very upset and felt that we were entitled to stay at his hotel in the room we had booked. We were so angry and disappointed that we turned around and drove home. He did not offer us any compensation for our petrol that we had wasted or a proper appology. Our faces obviously did not fit. If you do book to go here be prepared to end up in a different room to which you had requested despite confirmation. We went away to destress and have ended up even more stressed and extremely dissapointed. This hotel is supposed to have many awards and have a five diamond status - obviously not in customer service.
Absolutely Perfect
We stayed her for our first wedding anniversary in December 2003. The hotel was elegantly furnished and our room - the Empire - was, as described, deluxe. The staff were attentive yet discreet and our stay was so enjoyable we will be returning again in December.
Fantastic quality, great views, and only a short walk into to town.
Great customer service, well recommeded.
Needs a bit more customer service....
This hotel is in a reasonable location within a 10 minute walk to the centre of Bath. The problem is the staff. No offer to carry bags to the room or explain the facilities once you get there, for example. The room with four poster bed was OK but needed a good clean. The TV was tiny and far from the bed which made it useless. One of the most dissappointing aspects was breakfast. An unwanted wake up call to find what we wanted and when (it had been ordered the night before). Inferior quality yoghurts and just an unexciting selection. On departure no conversation from the receptionist. Overall, over-priced and not somewhere I'd recommend.
Beautiful Setting
We spent two nights this September at the Ayrlington hotel. The staff is friendly and our room was wonderful. We had evening views of the Abbey from our windows. Our room was very large and had a large 4 poster bed. The hotel is on a busy road and you may want to request rooms to the back of the house that are less noisy.
TripAdvisor Reviews The Ayrlington Bath
Travel Blogs from Bath
Royal Crescent, Gardens, American Mus., Stonehenge
... You can no longer walk up to and between the stones as it is roped off and you walk around it on a gravel path. It is still impressive. Having seen the Avebury stone circles a couple of days ago, the stones here are much bigger and closer together. They also seem more complete. While some say you can skip Stonehenge if you've seen Avebury, we're glad we did both as they are each unique in their own ...
Tour of Bath
... valuable in today's currency, it is the sheer quantity from a 200 year span that is impressive.
When we finished at the Baths, we walked around the corner to the Huntsman Inn to attend the 'Bizarre Bath' Street theatre at 8. It's a combination walk around Bath with humorous commentary and a bit of magic. If you like British humor at all, this is a really fun evening out and a good way to walk off ...
Moscow to Bath, England
... this site is the ability to get up close and personal. Also on site is a manor house that was restored for a BBC documentary. Unlike most restorations, each room in the house was restored to a different time period and because none of the furnishings are antiques you are encouraged to touch things, sit in chairs, lay on the beds, etc.
A note about the National Trust. If you are familiar with the US National Parks Passport Stamp program ...
Foot Bath
... you can still see the hot water bubbling up from its original spring.
We found ourselves near the station and were footsore and weary, so we went into a nearby pub. There were still a couple of places I wanted to see, and we also wanted to wait a bit before dinner - it was still too embarrassingly early to eat - so we recovered ourselves with a quick half. From there we walked towards and then along the river (the Avon). It's such a ...
Lovely day with the Lawtons
... Hotel Abbey and had drinks for a couple of hours – most enjoyable. Pete & Morgan are very nice people and no wonder their daughter is so sweet. Saying goodbye was certainly a bit emotional and I am pleased that Alexander is joining us at the Gartshores for Christmas because Emily has to work. Back to the hotel and we are currently watching Shrek – great movie. Great day and we can hear the church bells ringing. Christmas is exciting round ...


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Free Shipping
Product Information:
This DENY Designs fleece throw blanket may be the softest blanket ever! And we're not being overly dramatic here. In addition to being incredibly snuggly with it's plush fleece material, you can also add a photo or select a piece of artwork from the DENY Art Gallery, making it completely custom and one-of-a-kind! And when you've used it so much that it's time for a wash, no big deal, as it's machine washable with no image fading.
Product Details
We're sorry, we have no weights and dimensions for this product.
|Material: Polyester; Fleece
|Stain Resistant: No
|Embroidered: No
|Cleaning Method: Machine Wash
Reversible: Yes
|Country of Manufacture: United States
|Size: Throw
|Color: Multi-Colored
|Water Resistant: No
|Fade Resistant: Yes
|Hypoallergenic: No
|Organic: No
|Style: Traditional
|Theme: Nature
|Pattern: Nature/Floral
|Thread Count: 440
|Heated: No
|Electric: No
|Drying Method: Tumble Dry
|Pre-Shrunk: Yes
|Gender: Unisex
|Eco-Friendly: Yes
|Product Warranty: 30 days
|AZO Free: Yes
About the ManufacturerBased in Denver, Colorado, DENY Designs is a modern, think-outside-the-box home furnishings company. DENY empowers its customers to transform dull, everyday household accessories into fun and original statement pieces. With each DENY Designs purchase, their team of talented artists earn part of the proceeds, enabling DENY to support art communities all over the world while also spreading the creative love! From custom furniture pieces to textiles, if it's in the home décor category, DENY puts its own unique spin on it!
More About This Product
Free Shipping
Ships to:
Ships via: FedEx/UPS
Enter your shipping zip or postal code to calculate shipping estimatesGet Delivery Estimate
We want you to love it. If you don't, you may return your purchase within 30 days of delivery. All you need to do is visit our Self-Service Return Center for instructions. Return credits are issued within 24 hours once the item is received and inspected. Please note that shipping charges are non-refundable. The cost of return shipping will be deducted from your refund. 30-Day Return Policy
Overall Rating
Based on 4 reviews
Customer PhotosAdd your own photo
Looked Way Better Online! Laura from Roswell, GA on 07/23/2015 – Verified Buyer
When I actually saw this colorful blanket in person, I was disappointed. It was still pretty and really soft, but not as stunning as the pic online. From looking at the pic, I assumed the tree and its leaves would be made of many assorted fabrics, each a different texture. I also thought the tree fabrics would be embroidered onto the blanket, but it was only printed on. In person the effect was really FLAT, a little messy, and altogether underwhelming. The worst aspect of this item was its price--WAY TOO EXPENSIVE for such an unremarkable item. Pros: soft Cons: too expensive, cheap-looking
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Very soft and snuggly! Judy from Lansing, MI on 12/13/2014 – Verified Buyer
The design is just as shown with vibrant colors and I really like it. The weight of this really soft throw is not too light and not too heavy. We have it on our love seat and I use it often when I'm just a bit chilly. The size is generous for a throw. The reason for 4 stars is that the reverse is entirely white. That really doesn't bother me very much though. I'm very pleased!
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Printed throw Ann from Blaine, MN on 06/15/2014 – Verified Buyer
Colors are nice & fabric is soft, however, quality of printed design is disappointing. There were creases in the fabric when it was printed & they show as streaks of white through the design. It is no better than something at third of the cost from a discount store.
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very soft Mike from cabot, AR on 04/14/2015 – Verified Buyer
This is the third one I bought. Love them. So worth the money
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Buena Vista Motel
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
TripAdvisor Reviews Buena Vista Motel Kissimmee
Travel Blogs from Kissimmee
Today we drove early to EPCOT. We beat the crowds and the heat. I noticed that the AT&T communication ride had not changed any since the last time I rode it years ago. Harlan enjoyed it though.
Lunch was at a German Restaurant. Nice and cool inside. ...
"Make a joyful noise unto The Lord" - Psalm 100
Downtown Disney today a semi- sunny day. We decided on a Sunday brunch. A room full of folks praising The Lord and thanking Him for His goodness. Gospel Grammy winner Kirk Franklin joined forces with The House of Blues Orlando for an afternoon of food, gospel music and praise. We left physically and spiritually ...
Princesses, cartoons and magic kingdoms
... bell flying from the top of the castle in her lit up dress. And then the fireworks began, shooting in all different directions lighting up the sky. They were a sight to be seen themselves let alone in the beautiful surroundings with the castle as the centre point. Once they were over us and 50 billion other people began filing out of the park making our way to our van. Everyone was so exhausted that by the time we got back to the cabins we all went to sleep pretty ...
Orlando, Universal Studios with Grace!!
... It's amazing how much detail they put into everything to construct the place, it would be epic for children, they would think they were in the movie. Our favourite rides were the Hulk roller coaster at Adventure Island, and the Hollywood Rockit coaster at Universal. We did a lot of 4D rides but after a few they made me feel a bit crook. We got to have a Duff beer at Moes Tavern, the Simpsons World was pretty cool! Universal had an old school ...
Potter world!!!
... to the Golden Corral all you can eat buffet! It was busy and we were staving! We all pigged into dinner foods then lots of ice cream and chocolate covered strawberries. Then went back to our hotel to watch harry potter and the Deathly hallows part 2!!!! We all snuggled on the huge bed, plugged the DVD player in and talked, watched and laughed!! They dident end up leaving till 1am but we were so happy we got to spend the whole entire day with them!!! When they left we were dead tired and went to ...
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Super 8 Kissimmee SuitesGreen Acres, Kissimmee | 2 star motelfrom $42
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Motel 6 Orlando Kissimmee Main Gate WestWalt Disney World Resort, Kissimmee | 1 star motelfrom $38
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Continental Motel4650 West Irlo Bronson Memorial Highway, Kissimmee | Motelfrom $29
Flamingo Inn801 E. Vine St., Kissimmee | Motelfrom $53
Golden Link Motel4914 West Irlo Bronson HWY 192, Kissimmee | 2 star motelfrom $64
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Palm Motel4519 W. Irlo Bronson Highway, Kissimmee | Motelfrom $150


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Products/Services for ASTM D1785 Flange
Pipe Flanges - (428 companies)...that are perpendicular to the pipe to which they attach. Two of these surfaces are mechanically joined via bolts, collars, adhesives or welds. This video depicts the layout of a flange connection using bolts. Typically, flanges are attached to pipes via... Search by Specification | Learn More
No Image AvailableGas Fittings - (79 companies)...to several standards to ensure proper design and functionality. For example, ASTM C1541 + REDLINE is the standard specification for shielded transition couplings using flexible polyvinyl chloride (PVC) gaskets to connect dissimilar DWV pipe and fittings... Search by Specification | Learn More
No Image AvailableHydraulic Fittings - (245 companies)Flange fittings are rims, edges, ribs, or collars with flush surfaces perpendicular to the attached pipe or tube. These surfaces are joined and sealed via clamps, bolts, welding, brazing, and/or threading. For more information on flanges, visit... Search by Specification | Learn More
No Image AvailableSanitary Fittings - (106 companies)...are fittings which allow vessels to be connected by adhesive, solder, or other forms. Flanges - Ports with flush surfaces perpendicular to the attached vessel. These surfaces are joined and sealed via clamps, bolts, and/or welding. When connecting... Search by Specification | Learn More
No Image AvailablePneumatic Fittings - (190 companies)Pneumatic fittings are parts used to connect sections of pipe, tube, and hose in pneumatic (pressurized gas) lines and systems. Search by Specification | Learn More
No Image AvailableIndustrial Pipe - (1755 companies)...processing where media cleanliness is important. Platings such as nickel and chrome are sometimes used on industrial pipe for appearance or corrosion resistance. Flanged pipes are terminated at one or both ends with a flange for connection. Pre-insulated pipe... Search by Specification | Learn More
No Image AvailableFlange Protectors - (16 companies)Flange protectors are designed to protect flanges from damage during shipping, or from exposure to corrosive elements. These products are usually made of plastic, polyvinyl chloride (PVC), silicone, or vinyl. Some suppliers group flange protectors... Learn More
No Image AvailableFlange Mounted Bearings - (267 companies)Flange mounted bearings are used when a shaft axis is perpendicular to the bearing mounting surface. They are available in 2, 3, or 4-hole configurations. How to Select Flange Mounted Bearings. Flange Unit: 4-Blot. Mounted Ball Bearing: 2-Bolt... Search by Specification | Learn More
No Image AvailableTiming Pulley Flanges - (27 companies)...pulleys include options for flanges. Separate flanges are available for custom pulleys made from pulley stock. Timing pulley flanges are manufactured to fit timing pulleys of the same pitch and size. The dimensions of a pitch, including the mating flange... Search by Specification | Learn More
No Image AvailableVacuum Flanges and Fittings - (121 companies)...bulkhead flange, 45 degree elbow, 90 degree elbow, end cap or plug, full nipple, half nipple, "U " or 180 return, stub, tee, and viewport. Fittings, flanges or stubs can be provided in the form of a solid blank. Blanks can be machined to form... Search by Specification | Learn More
Product News
Xiamen Landee Industries Co., Ltd.
WN Flange, ASTM A105, 6 Inch LD 15 WNF 06 Keywords: Carbon Steel WN RF Flange, ASTM A105, SCH 80, 6". Name: 600# WN RF BW. Material: ASTM A105. Size: 6". Schedule: SCH 80. Surface Treatment: Black Coating. (read more)Browse Pipe Flanges Datasheets for Xiamen Landee Industries Co., Ltd.
Xiamen Landee Industries Co., Ltd.
ASTM A694 F42 Anchor Flange, SCH 80, 8 Inch Model No.: LD 14 AF 01 . China ASTM A694 Anchor Flange Manufacturer Landee Provides ASTM A694 F42 Anchor Flanges, Schedule 80, Class 600, 8 Inch, ANSI B16.5, Black Painting. Name: Anchor Flange. Size: 8". Thickness: SCH 80. Class: 600#. Material: ASTM A694 GR F42. Standard: ANSI B16.5. Surface: Black Painting. (read more)Browse Pipe Flanges Datasheets for Xiamen Landee Industries Co., Ltd.
American National Standards Institute, Inc. (ANSI)
ASTM Standards Download ASTM standards from ANSI. Search ASTM standards by document number or keyword. New standards are introduced every day - make sure you stay up to date. ASTM International standards are organized in 24 categories for browsing by topic. ASTM standards cover a diverse range of technology. ASTM standards for cementious and concrete materials, metals test methods and analytical procedures , health care and energy among others are available for download or site license. The entire collection... (read more)
ASTM International
ASTM Compass Your Portal for Standards, Testing, Learning & More. ASTM Compass gives your entire staff instant access to ALL the ASTM content you need including: standards, training, engineering publications, translations, and more. Build an ASTM Compass subscription to meet your needs and you'll improve productivity with: easy access to the standards you choose,. tools for adding notes, images, and attachments. sharing functions to help pass on and preserve corporate knowledge,. color-coded... (read more)
ASTM International
ASTM Training ASTM has a training program or course that meets your needs! Whether it's our award-winning continuing education courses or our industry-leading online training programs, you'll find the focused practical training that most impact your industry. Courses. ASTM Training and E-Learning Courses are high-quality, award-winning continuing technical education programs for industry and government. Our one to three-day seminars are intensive, focused and offer practical training on the standards... (read more)
MAIN Manufacturing Products, Inc.
ISO and SAE Hydraulic Flanges ISO & SAE HYDRAULIC FLANGES. MAIN Manufacturing Products offers flanges with an optional side port. Knowing the system pressures at various locations improves troubleshooting. Buying flanges with a gauge port is an easy and inexpensive method of ensuring that a gauge port, sampling port, or pilot port is available when and where needed. . It is a stock item in 1/4 NPTF and #4 SAE Straight Thread. Others (3/8 NPTF, #6 SAE Straight Thread, BSPP, BSPT, and ISO 6149) can ship... (read more)Browse Hydraulic Fittings Datasheets for MAIN Manufacturing Products, Inc.
MAIN Manufacturing Products, Inc.
Hydraulic Flanges Eliminate Our hydraulic reducing flanges eliminate that troublesome "Christmas tree look". MAIN Manufacturing Products stocks flanges with reduced port sizes. This eliminates the cost and leak paths that adapters create. . Because most are offered at the same price, the connection cost is reduced by the fitting and assembly costs. . Available in socket weld, St-Thd, NPTF, BSPP, BSPT and other female ports. Please visit our website at: www.mainmanufacturingproducts.com (read more)Browse Pipe Fittings Datasheets for MAIN Manufacturing Products, Inc.
MAIN Manufacturing Products, Inc.
Your Home for Hydraulic Flanges MAIN Manufacturing Products, Inc. has been serving the fluid power industry for more than 50 years! We offer hydraulic flanges that meet many different standards and other types of fittings and adapters. Click an item below to learn more: SAE Flanges. Square Flanges. Adapters/Fittings. Find-A-Flange. Create-A-Flange (read more)Browse Hydraulic Fittings Datasheets for MAIN Manufacturing Products, Inc.
MAIN Manufacturing Products, Inc.
Butt-Weld Flanges MAIN MANUFACTURING PRODUCTS, INC. has manufactured and distributed hydraulic flanges to SAE J518, ISO 6162, ISO 6164, JIS, and other flange standards for over 50 years. Main also manufactures and/or sells flange adapters, SAE split flanges, manifolds, subplates, special hydraulic connectors and other components. WHY USE MAIN MANUFACTURING?. EXPERIENCE & QUALITY - comes from over 50 years of experience, our employees' dedication to quality, and a well equipped and picky QC department... (read more)Browse Hydraulic Fittings Datasheets for MAIN Manufacturing Products, Inc.
Custom Timing Pulley Flanges MISUMI USA, Inc. manufactures custom timing pulley flanges to match your specifications. (read more)Browse Timing Pulley Flanges Datasheets for MISUMI USA
Power Plant Replacement Study
States > Louisiana > State > Regulations > Title 51 - Public Health -- Sanitary Code > Part XIV - Plumbing > 14 - Reference Standards
� Pipe, Steel, Black and Hot-Dipped, Zinc-Coated Welded and SeamlessTable 603ASTM A74-2009, Standard Specification for Cast Iron Soil Pipe and Fittings303.G.6.a, Table 703 ASTM A126-2004 (R2009), Standard � � Iron Castings for Valves, Flanges , and Pipe FittingsTable 603 � � Specification for Acrylonitrile- Butadiene-Styrene(ABS) Plastic Pipe, Schedules 40 and 80Table 603ASTM D1785 -2006, Standard Specification �


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Select Local Merchants
Century OrthodonticsRead MoreLooking for a new dentist? Try Saint Louis' Century Orthodontics for professional and affordable dental treatments. Keep your oral health up to par with a dental treatment, such as fillings, check up, cleaning, crowns and veneers, and orthodontia. The dentists at Century Orthodontics are ready to assist you with all of your dental needs so book an appointment today.8000 Bonhomme AveSaint Louis, MO US
Matthew F StrohmeyerRead MoreHead to Matthew F Strohmeyer in Saint Louis for your next dental cleaning and leave with a pearly white smile. The oral care remedies at this dentistry will leave you feeling clean, refreshed and healthy. This dental clinic is appointment-only to ensure they have time exclusively devoted to you. Scheduling you next appointment is quick and easy at Matthew F Strohmeyer so give the office a call today and be on your merry way.8764 Manchester RdSaint Louis, MO US
John N ChiapelRead MoreBrighten up your smile with a professional teeth whitening service from John N Chiapel in Grover. From fillings, check up, and crowns and veneers to routine cleanings, this dentistry offers a number of oral health services. Book your next dental appointment at John N Chiapel and leave with a healthier and cleaner mouth.16921 Manchester RdGrover, MO US
Seth A Wasson DMDRead MoreThe staff at Seth A Wasson DMD in Saint Louis is known for making dental check-ups stress free and quick. When your smile needs some aid, dental clinic can help with services like fillings, check up, and crowns and veneers. Dental cleanings are a breeze when you call and schedule an appointment at Seth A Wasson DMD.2440 South Brentwood BoulevardSaint Louis, MO US
Artistic DentistryRead MoreDr. Pete Pagano is following in the family footsteps: after practicing dentistry with his father for 15 years, during which he augmented his formal education with the knowledge gleaned from his real-world experience, he took over the practice after his dad retired. Today, at Artistic Dentistry, Dr. Pagano still treats patients whose teeth were inspected by his father, as well as those of their children and grandchildren. With the aid of a skilled staff, Dr. Pagano delves into patients' facial caverns to seek out tooth decay, oral cancer, and gummy bears wanted for arson. Then, he treats mouths with any necessary procedures such as fillings, implants, and crowns or brightens smiles with teeth whitening. Whether performing a root canal or polishing teeth until they shine more than Zeus's trophy for Best Deity, the dental professionals at Artistic Dentistry make sure to treat their patients as whole people and not just mouths by thoroughly discussing procedures and answering any questions.12334 Olive BlvdCreve Coeur, MO US
St Louis Dental Implant CenterRead MoreTired of home teeth whitening treatments? Head to St Louis Dental Implant Center in Creve Coeur for a professional teeth whitening treatment and teeth cleaning. When you take advantage of an oral health service from St Louis Dental Implant Center, such as fillings, check up, cleaning, and crowns and veneers, you can keep your gums and teeth healthy. Going to the dentist has never been easier when you call St Louis Dental Implant Center for quality care.658 N New Ballas RdCreve Coeur, MO US


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Hubbell Lighting
Hubbell Lighting
Hubbell Outdoor
Established in 1963, Hubbell Outdoor Lighting has built a reputation as an industry leader by offering a wide range of products such as landscape lighting, flood lighting, roadway, security lighting and area/site lights.
Columbia Lighting
Columbia Lighting offers a wide range of commercial and industrial fluorescent fixtures that have been used in office, educational, retail, and health care applications.
Kim Lighting
For over 80 years, Kim Lighting has provided high quality, high-performance architectural and landscape lighting products such as roadway, pedestrian, low-level and building mounted solutions that are suitable for a variety of commercial applications.
Litecontrol is well known for their architectural suspended and recessed fluorescent and LED luminaires. They also specialize in wall/slot lighting. These product options make it an ideal choice for a variety of commercial applications like schools, offices, retail, hospitality and other public spaces.
Alera Lighting
Alera Lighting offers architectural LED and fluorescent lighting such as linear suspended, recessed, surface and wall mounted fixtures for commercial use in offices, retail, education, health care, corporate campus, places of worship and youth centers.
Beacon Products
Beacon Products specializes in roadway, parking and area luminaires, as well as poles and bollards that are suitable for a wide variety of commercial and industrial applications.
Compass offers exit and emergency lighting systems that are value-driven and contractor-friendly, making it a popular choice among trade professionals.
Kurt Versen
Kurt Versen is known for their architectural specification-grade downlighting fixtures that have been speced by architects and designers for a wide range of office, retail, government, entertainment, hospitality and institutional applications.
Since 1944, Prescolite has been servicing the residential and commercial markets with its wide range of recessed, surface and track lighting products.
Dual-Lite offers a broad selection of commercial and industrial life safety products such as exit and emergency systems that are aesthetically pleasing and energy-saving.


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Hermosa imagen.. LIKE 1 Un amable saludo, Chaydeé.
C haydeé My Panoramio friend I am very happy you like this photo. It is a pleasure to see you on the pages with photos and see your comments, thank you. Best regards Kosmas
Nice situation catched. FAV+LIKE. Greetings, Heinz.
Far lang My friend many thanks for your nice comment. Best regards Kosmas
Photo taken in Kebili South, Tunisia


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Try My Nuts Nut Company
How Hot Can You Handle It?
The Try My Nuts phone app is now available for download at the Apple App Store and the Google Play Store.
Download it to receive special savings both in our retail locations as well as online. There's a loyalty program, pictures, videos and more! New stuff will be added all the time.
Check Out All Our Video Reviews In Our New Video Reviews Section
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What our happy customers are saying about our nuts...
""OMG! First summer at OBX and we spent a lot of time in TMN. I've been home about a week and just finished the last of the white chocolate covered cashew toffee - put the crumbs in my breakfast yogurt!"
Americus, GA
Ok, seriously, these nuts are friggin sweet. Trust me. I'm a fat college senior who studies, parties, and eats, that's it. I CAN'T BELIEVE HOW DAMN GOOD THEY ARE. At this moment, my housemates and I are assembling a massive internet order. Mr. Planters Nuts are like eating beef jerky in place of a t-bone. YOU TRY THOSE NUTS, AND YOU WILL LIKE EM. I GUARANTEE.


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Visit any of our locations where our teaologists have been fully trained in the way of tea and can help you with any of our 110 teas and find the ones suited to your palate.
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Westroads Mall Teavana Store
Store Address:10000 California St. #2420
Omaha, Nebraska 68114
United States
Store Hours:
- Monday10:00AM - 9:00PM
- Tuesday10:00AM - 9:00PM
- Wednesday10:00AM - 9:00PM
- Thursday10:00AM - 9:00PM
- Friday10:00AM - 9:00PM
- Saturday10:00AM - 9:00PM
- Sunday10:00AM - 9:00PM