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Photo reflection from 2014 meet.
South Carolina Track & Field and Cross Country News
Schools from six states converge on the Furman University Golf Course this weekend for the 43rd running of the Gene Mullin/Furman Invitational in Greenville.
Database-combined results from county meets in 2014.
Our latest release of the ASICS Future Stars series is highlighted by the first frosh sub-15:00 3-mile of 2015!
scrunners onsite at Furman meet Saturday morning.
This is the first in a three-part series looking at the high school cross country coaching profession in South Carolina.
Several meets canceled last weekend due to inclement weather.
Action from Oct. 2-3 weekend.
Dave Lee of James Island talks about the program and expectations.
Brooks Hovis and the Generals run 20 200s Oct. 5. Hovis' group ran between 31-34 seconds.
Check out the latest release of the ASICS Future Stars series!
With a big win at the McQuaid Invitational, the Shenendehowa girls become the third New York team to join the top five
The Sandburg boys of Illinois split their varsity squad this weekend for two victories. They move ahead of pre-season favorites CBA, who are still waiting to debut top runner Blaise Ferro
scrunners and the SCTCCCA will be acknowledging the runner of the week each week throughout the season.
The 2015 Mike Moore Shrine Bowl Run applications are available and due Nov. 2 by 3 p.m.
St. Joseph girls coach talks about the season and coaching.
Waccamaw leads Class AA girls team database rankings.
Academic Magnet leads Class AA boys, Landrum second.
Hilton Head girls number one, Eastside second.
Hilton Head boys lead Class AAA, Eastside second.
Watch practically any high school cross country or track event in the state and chances are the name of at least one, and more often several, SCISA-member schools and their student/athletes will be mixed in with their peers on the public school side at or near the top of the final-results list.
These sophomore boys are getting really good, watch out upperclassmen!
Meet management announced today Wendy's Invitational has been canceled due to expected inclement weather in the Charlotte area.
Wade Hampton Generals lead Class AAAA boys.
Riverside girls number one, Dutch Fork two.

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|Table of Contents
|Vol. 34, No. 3, 2011
Issue release date: September 2011
|Section title: Nephrology Grand Rounds
Mutation in the Tight-Junction Gene Claudin 19 (CLDN19) and Familial Hypomagnesemia, Hypercalciuria, Nephrocalcinosis (FHHNC) and Severe Ocular DiseaseNaeem M.a · Hussain S.a · Akhtar N.b
aDepartment of Biotechnology, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, and bDepartment of Nephrology, The Children's Hospital and The Institute of Child Health, Lahore, Pakistan Corresponding Author
Assist. Prof., Dr. Muhammad Naeem
Department of Biotechnology
Faculty of Biological Sciences, Quaid-i-Azam University
Islamabad 45320 (Pakistan)
Tel. +92 51 9064 4119, E-Mail firstname.lastname@example.com
Background/Aims: Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a rare renal tubular disorder complicated by progressive renal failure during childhood or adolescence. Recently, causative mutations in the CLDN19 gene have been identified in FHHNC patients presenting with severe ocular involvement. The aim of the study was to investigate the molecular genetic defect underlying FHHNC in a consanguineous Pakistani family. Methods: Clinical and biochemical parameters of the proband were studied during the follow-up period over 5 years. Genotyping of 7 members of the family was performed by amplifying microsatellite markers, tightly linked to the CLDN16 and CLDN19 genes. The two genes were sequenced directly in an automated sequencer. PCR-RFLP assay and bioinformatic analysis were performed to verify the identified mutation. Results: Genotyping revealed that the proband was homozygous for the marker loci tightly linked to the CLDN19 gene. Sequence analysis in the proband revealed homozygosity for a novel missense mutation in exon 3 of the CLDN19 gene (389G>A) resulting in G130D amino acid substitution. Bioinformatic analysis supported the pathogenicity of the identified mutation. Family screening revealed nephrolithiasis in 3 of 6 (50%) heterozygous carriers of the pathogenic mutation. Conclusion: This study supports the fundamental role of claudin 19 for magnesium homeostasis, normal tubular structures in the kidney, and undisturbed organization and development of the retina.
© 2011 S. Karger AG, Basel
Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) was first described in 1972 [1] and is characterized by excessive renal magnesium and calcium wasting and nephrocalcinosis [2]. The disorder is inherited in an autosomal recessive fashion and usually leads to end-stage renal disease (ESRD) in the second to fourth decades of life. The clinical appearance in affected patients is often uniform, although time to ESRD shows considerable variation, even among siblings. All affected individuals exhibit marked hypomagnesemia with hypercalciuria and nephrocalcinosis. The severity of nephrocalcinosis is usually correlated with rapid progression to ESRD, but this association was disputed in some of the literature [3,4,5,6]. Other symptoms at onset include recurrent urinary tract infections, nephrolithiasis, polyuria, polydipsia, failure to thrive, muscular tetany, hypocitraturia, impaired glomerular filtration rate and incomplete distal renal tubular acidosis [7]. Ocular abnormalities and hearing impairment have been reported as inconsistent extrarenal findings. The only known cure is renal transplantation; however, symptomatic treatment in the form of magnesium citrate and calcium replacement, or the use of hydrochlorothiazide only delays the onset of ESRD [3]. Mutations in the gene CLDN16 mapping to chromosome 3q27 were identified as the underlying genetic defects in FHHNC. CLDN16 encodes claudin 16 (CLDN16), a tight-junction protein of the claudin multigene family that is expressed in the thick ascending limb of Henle (TALH) and the distal convoluted tubule [8]. Several mutations in the CLDN16 have been reported so far.
Konrad et al. [9] mapped another gene (CLDN19) for autosomal recessive renal magnesium loss to chromosome 1p34.2 in patients affected by FHHNC and significant ocular abnormalities, including macular colobomata, nystagmus and myopia. CLDN19 encodes for claudin 19 (CLDN19), a recently identified member of the claudin multigene family. CLDN19 is expressed at high levels in the kidney and the eye. To date, six different mutations have been reported in the CLDN19 gene [9,10]. In this paper, we describe a novel CLDN19 mutation in a Pakistani family affected with FHHNC and severe ocular disease.
The proband was a 19-year-old boy from a consanguineous Pakistani family (fig. 1a) living in a remote village in Punjab province. The proband and his family members were clinically examined at the Children's Hospital and the Institute of Child Health, Lahore, Pakistan. Before the start of the study, approval was obtained from the Quaid-i-Azam University institutional review board. In addition, informed consent was obtained from the family members (III-1, III-2, IV-1, IV-4, IV-6, IV-7 and IV-8) who participated in the study.
Venous blood samples were obtained from 7 family members and genomic DNA was extracted from whole blood following a standard protocol. Microsatellite markers tightly linked to the CLDN16 (D3S3686, D3S3651, D3S3628) and CLDN19 (D1S3721, D1S2130, D1S2645) genes were polymerase chain reaction (PCR) amplified from genomic DNA. The PCR was carried out according to a standard procedure in 50-µl reaction volumes containing 100 ng of genomic DNA, 20 pmol of each primer, 200 µM of each deoxynucleoside triphosphate, 2.5 units of Taq DNA polymerase (MBI Fermentas) and 1× PCR buffer. The thermal cycling conditions used were: 95°C for 5 min, followed by 40 cycles of 95°C for 1 min, 53–58°C for 1 min, 72°C for 1 min, and a final extension at 72°C for 10 min. PCR was performed by use of the Palm-Cycler gradient thermal cycler (Corbett Life Science, Australia). The PCR products were resolved on 8% non-denaturing polyacrylamide gel and genotypes were assigned by visual inspection.
To screen for the mutation, each of the exons and adjacent exon/intron boundaries of the CLDN16 and CLDN19 genes were PCR amplified from genomic DNA using primers designed from intronic sequences of the two genes. The sequences of the primers are available upon request. PCR products were purified using the Gene JET PCR purification kit (Fermentas Life Sciences) and were sequenced in Applied Biosystems automatic sequencer 3730XL, using the BigDye terminator cycle sequencing kit V3.1 (PE Applied Biosystems, Foster City, Calif., USA) following purification by ethanol precipitation. Sequence variants were identified using BioEdit Sequence Alignment Editor version 22.214.171.124.
The identified mutation obliterated the restriction site for Stul enzyme, so its presence was assayed by PCR amplification of CLDN19 exon 3 from genomic DNA, digestion of the product with Stul (Fast Digest, Fermentas Life Sciences), and separation of the resulting fragments by agarose gel electrophoresis with direct visualization using ethidium bromide.
Multiple sequence alignments of CLDN19 proteins in 18 vertebrate species and other related members of the human claudin superfamily were generated with T-Coffee [11]. The effect of amino acid substitution on protein function was predicted using SIFT (sorting intolerant from tolerant), PolyPhen, PANTHER and Align-GVGD [12,13,14,15]. A reference protein sequence (ENSG00000164007) of the human CLDN19 gene was used as the input for SIFT, PolyPhen and PANTHER. Default query options were used for SIFT and PolyPhen prediction. MSA of the CLDN19 proteins in vertebrate species was used as the input MSA for Align-GVGD. The CLDN19 reference protein sequence and mutant CLDN19 sequence were analyzed by the GOR IV secondary structure-prediction method [16].
The patient with short stature (–3.2 SDS below the mean for chronological age) was referred for polyuria, polydipsia and recurrent attacks of tetany at the age of 14 years. He was the youngest child in a consanguineous family and was born at term after a normal pregnancy. Laboratory investigations revealed hypomagnesemia, hypocalcemia, hypermagnesuria and hypercalciuria (table 1). Arterial blood gases and serum electrolytes were normal. Radiological examination (fig. 1b–d) revealed bilateral nephrocalcinosis and renal osteodystrophy including genu valgum (knock-knee) deformity. Ophthalmologic examination revealed severe ocular abnormalities (fig. 1e–g) including macular colobomata of the left eye and posterior staphyloma in the right eye. The patient had significant myopia with 15° left exotropia and nystagmoid movement in left gaze. In addition, both eyes showed increased tortuosity of the retinal arteriolar vessels. Since both parents were healthy, the inheritance pattern was likely to be autosomal recessive. The patient was treated with magnesium and calcium salts, calcitriol, potassium citrate and hydrochlorothiazide. Serum calcium and magnesium levels were not normalized after treatment, whereas urinary calcium/creatinine and magnesium/creatinine ratios were reduced.
Screening of the phenotypically unaffected members of the family was performed for hypomagnesemia, hypercalciuria, nephrocalcinosis and nephrolithiasis. One individual (IV-7) revealed bilateral nephrolithiasis (an 8.5-mm stone in the middle calyx of the right kidney and a 12-mm stone at the right UV junction, while an 8.8-mm stone was present in the middle calyx of the left kidney). Two members (IV-1, IV-6) revealed unilateral nephrolithiasis (8.9- and 11-mm stones, respectively) in the middle calyx of the left kidney.
Genotyping of the patient and 6 normal individuals of the family was performed with microsatellite markers mapped in the regions of CLDN16 and CLDN19 genes. The markers were fully informative, and the results revealed that the patient was homozygous for the markers D1S3721, D1S2130 and D1S2645, suggesting linkage to the CLDN19 gene (fig. 1a). However, both the CLDN16 and CLDN19 genes were screened for mutation detection in the proband and his family members. Sequence analysis of exon 3 of the CLDN19 gene revealed a G to A transition at nucleotide position 389 (fig. 1h), resulting in glycine to aspartate (G130D) amino acid substitution. The mutation was confirmed by bidirectional DNA sequencing. The parents (III-1, III-2) and 4 normal individuals (IV-1, IV-4, IV-6 and IV-7) of the family were heterozygous for the mutation. To ensure that the mutation does not represent a neutral polymorphism in the Pakistani population, 100 ethnically matched healthy control individuals were screened for the mutation by PCR followed by direct sequencing and StuI restriction assay (fig. 1i). The mutation was not identified outside the family. Sequence analysis also revealed a synonymous single- nucleotide polymorphism (c.261C>T) in exon 2 of the CLDN19 gene in a homozygous condition in the affected and normal individuals of the family. No other sequence variant was identified in the family in either the CLDN16 or the CLDN19 gene.
Multiple alignment of the amino acid sequence of the CLDN19 gene among 18 vertebrate species using T-Coffee revealed 47% identity and 63% similarity. The identity and similarity in the third transmembrane domain (TMD) were 17 and 30%, respectively (among the claudins, the amino acid sequences of the first and fourth transmembrane segments and the first and second extracellular loops are highly conserved, whereas the sequences of the second and third transmembrane domains are more diversified) [17]. The G130 residue in the third TMD was completely conserved among CLDN19 genes across all species (fig. 1j). Multiple sequence alignment of the human CLDN19 with human claudin 1, 3, 4, 7, 8, 10, 11 and 16 was also performed. The analysis revealed that G130 was highly conserved (78%), existing as either a glycine or an alanine (similar hydrophobic) amino acid. These eight claudins, in addition to CLDN19, are known to reside in the distal tubules and collecting ducts, and their roles in paracellular transport of cations in the renal tubules have been demonstrated. The biological importance of these claudin members in renal and other organs has been demonstrated in mutants and gene-targeting studies as well [18]. Evolutionary conservation analysis of mutated amino acid residue G130 utilizing amino acid substitution matrix (PAM 260) revealed a log odd score of 5.0 for a G to G self-substitution, 1.0 for a G to D substitution and ≤1.0 for any other substitution at this position. A lower score indicated that G to D is not a favored substitution at this position.
The pathogenicity of G130D mutation was supported by SIFT analysis, which predicted that G130D substitution will affect the protein function with a probability score of 0.00 (the threshold score for intolerance of a substitution was 0.05; the amino acids with probabilities of <0.05 were predicted to be deleterious). Polyphen analysis predicted G130D substitution to be probably damaging with a score of 2.392 (score ranges from 0 to a positive number, where 0 is neutral, and a high positive number is damaging). PANTHER predicted G130D substitution to have a deleterious effect on protein function. The PANTHER subPSEC (substitution position-specific evolutionary conservation) score was below –3; the previously identified cutoff point for functional significance and the probability of functional impairment (Pdeleterious) was 0.65 [19]. ALIGN-GVGD analysis predicted that G130D substitution will most likely interfere with protein function (class C65). The GOR IV secondary structure-prediction method predicted that replacement of glycine with aspartic acid at position 130 in the third TMD of claudin-19 may disrupt the arrangement of adjacent extended strands in the protein. This may be due to the fact that glycine is a very unique amino acid in that it contains hydrogen as its side chain and therefore offers extraordinary conformational flexibility.
Epithelia serve as selective and protective barriers in multicellular organisms. Epithelial cells are interconnected by a series of intercellular junctions, collectively known as the epithelial junctional complex, which is composed of tight junctions (TJs), adherens junctions and desmosomes. The TJs are heteromeric protein complexes that form the principal barrier or gate to selectively regulate paracellular diffusion. They also act as a molecular fence to maintain cell polarity by separating the apical and basolateral membrane components. In addition, the TJs act as signaling centers by mediating the bidirectional transmission of information between the environment and the cell interior to control paracellular permeability and differentiation. The major components of the TJs are claudins, which form ion-selective paracellular pores through the TJs and determine the selectivity of the paracellular transport. Claudins are a large multigene family consisting of 24 members in mammals. The tissue-specific expression of different claudins underlies the different barrier properties seen by different types of epithelia. Claudins bear four transmembrane domains (fig. 1k), a short intracellular NH2-terminal sequence (∼7 residues), a large first extracellular loop (∼52 residues) and a shorter second extracellular loop (∼16–33 residues), and a cytoplasmic COOH-terminal sequence that varies considerably in length (∼21–63 residues) between different isoforms [20,21]. The only inherited disease known to be caused by claudin mutations so far is FHHNC. The responsible proteins CLDN16 and CLDN19 are required for renal reabsorption of Mg2+ in the TALH [10], where approximately 50–60% of the filtered Mg2+ is reabsorbed via the paracellular pathway [22]. CLDN16 and CLDN19 completely colocalize in the TALH and thin ascending limbs of Henle. However, CLDN19 is also expressed at high levels in the retina [9]. When coexpressed in a yeast two-hybrid system, CLDN16 and CLDN19 interact in a synergistic manner and form a cation-selective TJ complex [10]. These data explain the fact that CLDN19 mutations are associated with a similar phenotype to that due to CLDN16 mutations except that the patients manifest severe ocular involvement.
In this study, we have identified a novel CLDN19 mutation in a Pakistani patient with FHHNC and severe ocular disease. The identified mutation (G130D) replaces a neutral with a negatively charged amino acid located in the third TMD of claudin-19 protein. Six different mutations have been reported in the CLDN19 gene so far [9,10,23,24]. The mutations, G20D and P28L lie in the first TMD; V44M and Q57E lie in the first extracellular loop; L90P lies in the second TMD, and G123R lies in the third TMD of the protein. CLDN19 significantly lost its function when any of the mutants (G20D, Q57E, L90P, G123R) were expressed in LLC-PK1 cells. In the yeast two-hybrid assay, G123R mutation severely affected CLDN19 heteromeric interaction with CLDN16 [10]. Moreover, the G130D mutant is homologous to the previously reported claudin-16 mutant G198D, also responsible for FHHNC [25]. Transfection of LLC-PK1 cells with the G198D mutant showed no variation at the level of transcription; while the mutant protein was not detectable with immunofluorescence staining or Western blotting, suggesting that it was instantly degraded [26]. Therefore, the G130D mutation in CLDN19 may be predicted to cause loss of protein function and affect the heteromeric interaction of CLDN19 with CLDN16.
Serum calcium and magnesium levels in the patient presented herein remained low despite administration of calcium and magnesium supplements, as previously reported [3]. Hydrochlorothiazide is known to reduce urinary calcium excretion rates and increase magnesium uptake in a dose-dependent manner [27]. However, in a study of 25 FHHNC families [3], no sustained reduction of hypercalciuria was achieved in the majority of patients with hydrochlorothiazide treatment. In our patient, hydrochlorothiazide administration reduced the urinary calcium/creatinine ratio and magnesium/creatinine ratio (table 1), as previously reported [5]. In contrast, the glomerular filtration rate decreased from 83 ml/min/ 1.73 m2 (stage 2 of chronic kidney disease) at the time of diagnosis to 52 ml/min/1.73 m2 (stage 3 of chronic kidney disease) at the end of follow-up. Therefore, the calcium/creatinine ratio in our patient did not correlate with the extent of renal impairment as previously described [3,5].
The proband presented with severe short stature (–3.2 SDS below the mean for chronological age), and substitution of calcium, calcitriol and hydrochlorothiazide did not improve his height during the follow-up period. Growth failure is a well-documented clinical manifestation in hereditary tubular disorders. However, the median body height in previously reported FHHNC patients varied from –0.9 to –1.7 SDS, while only 1 patient had SDS below –3.0 [5,28] and all patients benefited from the substitution of calcium, calcitriol and hydrochlorothiazide [5]. Sanjad et al. [29] recently described extreme short stature (median body height –6.9 SDS) in an FHHNC family with the CLDN16 gene mutation. However, the role of the CLDN16 gene mutation in the short-stature phenotype in their reported family was inconclusive because 1 unaffected sibling, an obligate heterozygote, was also short.
Ultrasongraphic examination of both kidneys of heterozygous members of the affected family revealed either unilateral or bilateral nephrolithiasis in 3 of 6 (50%) individuals. Comparable observations have previously been reported in families affected with FHHNC due to CLDN16 gene mutations [3]. It has been suggested that mutation analysis of families affected by familial hypercalciuria with nephrocalcinosis and/or nephrolithiasis (with an apparently dominant mode of inheritance) would demonstrate heterozygous mutations in the CLDN16 gene in a number of families. A similar relationship may be expected between isolated hypercalciuria/nephrolithiasis and CLDN19 gene mutations.
The identification of a novel mutation in the CLDN19 gene strengthens the evidence that FHHNC with severe ocular disease is caused by a dysfunction of the renal TJ protein CLDN19. The study supports the crucial role of CLDN19 in the formation of TJs in the kidneys to maintain magnesium homeostasis and its important role in the eye in the organization and development of the retina. However, further studies are required to establish the exact molecular mechanism of mutations in the development of FHHNC. Understanding the molecular defects of CLDN19 in FHHNC patients should be helpful in the genetic counseling of affected families and may improve specific therapeutic strategies to prevent the development of ESRD in the future.
We wish to thank the family members for their invaluable participation and cooperation. This work was supported by the Higher Education Commission (HEC), Islamabad, Pakistan. Written consent for publication was obtained from the patient and his relatives.
Assist. Prof., Dr. Muhammad Naeem
Department of Biotechnology
Faculty of Biological Sciences, Quaid-i-Azam University
Islamabad 45320 (Pakistan)
Tel. +92 51 9064 4119, E-Mail email@example.com
Published online: 7/26/2011
Issue release date: September 2011
Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 1
ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)
For additional information: http://www.karger.com/AJN
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
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It has been a while since a new product has come out on the market in the search engine space that actually works well, and is actually fairly interesting in how they present data. Cuil was released to the public this morning, and it is truly something very cool.
A New Search Engine For Surgeons Launches
Contemporary Surgery, along with help from Convera, has launched a new search engine at SURGERYFINDIT.COM. This new search engine tool provides targeted search results for surgeons.
Microsoft Gets HP's "Default Search Engine" Status
Less than two years ago, Yahoo was on a roll and had just signed a deal with computer manufacturer HP that would see its search engine as the default on all new HP computers.
Search Engine Geared Towards African-Americans, Good Business Or Bad?
Last week, IAC introduced a new search engine, Rushmore Drive, aimed at the roughly 12.4 million African-Americans online in the US.
My question for any African-American reader–and anyone else who has an opinion–do you really want such a search engine?
More On Using Google Can Become A Habit
Google, Search Drives Health, Travel Traffic
Websites in the health & medical and the travel categories received substantial traffic driven to them from search engines in November 2007.
November Search Share, A Poem
Google picked up more than 65 percent of the US search market in November 2007, while Yahoo, Microsoft, and Ask all ceded a few tenths of a percent each in share.
AskEraser Elevates Privacy Standard For Search
Ask.com launched its AskEraser service across all of the search engine's products, where people can opt to erase their search history with a single mouse click.
SES Chicago: Soaring Through Universal Search
Searchers represent a valuable commodity to search engines, and the keen-minded technologists behind the algorithms want to make search sites as useful as possible, no matter what the query.
Publishers Push ACAP As Robots.txt Improvement
The Automated Content Access Protocol (ACAP) debuted today as a set of improvements to deficiencies seen in the robots.txt protocol currently observed by search crawlers.
Ask.com Gobbles Up Thanksgiving Week
Turkey queries and Black Friday deal searches rate among the places Ask believes its search engine can help the typical person around the holidays.
Microsoft Counts To 40 By Tens
Schoolhouse Rock or corporate strategy? Microsoft wants to achieve online advertising goals with its businesses, while measuring success with a 10, 20, 30, 40 yardstick.
Yahoo Queries The Obscure
Search queries that engines like Yahoo's rarely see can be problematic for the technology, and frustrating for the searcher who doesn't receive a relevant response.
Google Advanced Search Spam Poses Threat
A sample of a spam message making the rounds demonstrated how someone used a Google URL, with advanced search operators, to send people to a fake retail site. It could be much worse.
IAC: Ask.com Growth Offset By Lending Tree
Search & Media performed well for IAC, but the continued troubles in the housing market reduced the impact of Ask's gains.
Truveo Taps Kewego For European Video
Truveo, owned by AOL, has expanded its reach into international video content by sealing a deal with Kewego to index videos from major European producers.
Google Stock Crested $600 Per Share
The GOOG spent a brief time over the $600 mark, putting it in some pretty good company for a few minutes.
Search Share Same As It Ever Was
August figures for search engine share as recorded by Compete found Google with two-thirds of queries made during the month.
When Spies Do Search
The Central Intelligence Agency launched CIA Wire, a service that will help users of the Library of National Intelligence sift through available information from participating agencies.
SES: Search Engines Talk Click Fraud
At SES San Jose, representatives from the big four search engines talked about the persistent threat of click fraud, and how they are fighting back to protect their advertisers.
ComScore qScore Tallies Well For Google
Search sites measured by comScore under their new qScore 2.0 methodology will benefit from the hosted and affiliated search traffic they send back to the main search engine. It's a scenario that offers Google a heaping helping of share by comScore's reckoning.
SES: Cruising The Search Landscape
Session talkers at SES San Jose 2007 bounded around the topic of the search landscape: what's popular, and who's the most used among the major players in search.
SES San Jose Opens Today
Four days of the search industry's biggest gathering starts in San Jose, where attendees can learn the finer points about marketing effectively and ranking well with the drivers of search-related traffic.
Lanzone, Mayer To Keynote SES San Jose
Ask.com CEO Jim Lanzone and Google VP of Search Products & User Experience Marissa Mayer will be the featured keynote speakers at next week's SES San Jose conference.
Google Search Results: Your SERPs At Risk
Third parties could hack someone's place in Google's SERPs right out of the index with some malicious proxy work.
Product Information? Search Comes First
Visitors to one's online retail website have a great likelihood of starting from a page of search results, as shown by last holiday season's activity.
Microsoft Search Gained Without Club Live
When web services firm Compete stripped out the Club Live numbers from MSN/Live Search share, Microsoft still enjoyed a month to month gain in search.
Search: Tell Them How-To Do It
People want to know how to tie a necktie and would really like their favorite search engine to give them a hand.
Accoona Heads To Wall Street, Plans IPO
The Accoona search engine first launched in 2004 with a proprietary artificial intelligence technology backing its query engine.
LookSmart CEO Hits The Eject Button
President and CEO David Hills has jumped ship from the company, citing a desire to start another business.
Can You Answer Rand's SEO Questions?
Rand Fishkin thinks a competent SEO firm ought to be able to handle ten questions about the search industry, and an eleventh if they are really knowledgeable about their work.
Searchers Want The Xbox 360, Preferably Cheap
Queries for Microsoft's gaming console have exceeded those for Nintendo's hard to find competitor, the Wii.
Avatar Seeks Semantic Search
Researchers at IBM Almaden have been developing a semantic search process that can delve into unstructured text to retrieve structured information.
Microsoft Joins Ask In Call For Privacy
Search engines have faced mounting scrutiny over their data retention and privacy practices, and Microsoft and Ask likely wish to head off potential increases in federal scrutiny.
Ask Readies AskEraser Privacy Controls
Ask.com will take its research with privacy advocates at the Center for Democracy & Technology into a new product for their search engine.
Profits Fall At Yahoo, But Don't Blame Search
Jerry Yang's return as Yahoo CEO experienced a less than auspicious start to his first time back at the helm for an earnings announcement, as the numbers showed a dip in display ad performance.
Google Dips But Leads Search In June
Their lead faded slightly to 49.5 percent of the US search market, but that was good enough for Google to easily best the field for June 2007.
Users Rely On Search For Health Information
About 65 percent of online health consumers say they click on results because of its relevance to a particular query while 16 percent choose a result based on the trustworthiness of it source according to a new JupiterResearch report, "US Online Health Consumer Survey, 2007: Understanding Search Behavior."
SEOmoz Simplifies SEO
Now that the SMX Advanced conference has faded into memory, Rand Fishkin has posted something for those who may not be advanced enough for SMX topics.
Ask3D Cuts Back On 'Search Skim'
The product managers for Ask.com's revamped interface and presentation contend their design helps cut back on the wasted effort searchers expend when looking for good search results.
The Name Is Crawl. Yahoo Crawl
Yahoo Slurp, the portal company's search crawler, has been migrated to its new domain at crawl.yahoo.net and is coming to a web server near you.
SES Says No Speaker Exclusivity Planned
Whispers about potentially requiring speakers at Search Engine Strategies conferences to not speak at competitor shows have been dismissed as untrue.
Ask Morphs Into Ask3D
If anyone was wondering why IAC put up a $100 million marketing budget behind Ask.com, the relaunch of the search engine as Ask3D should answer that question.
Microsoft Building New Engine, World Shrugs
Rumors of a new effort by Microsoft to tap Silicon Valley's bright young techies and build a better search engine have been met with a collective arching of the shoulders.
Mahalo To Curate Web Search
Substantial buzz has accompanied Jason Calacanis' startup debut of Mahalo, a search site with human editors refining the results for the currently 4,000 top search terms.
|"Mahalo To Curate Web Search"
Google Gains In Search, Yahoo Slips
Google sites captured 49.7 percent of the U.S. search market for the month of April, gaining 1.4 share points from the previous month according to comScore.
Big Brands Clueless On Site Search
Visiting the website for a major consumer brand should lead people to a useful, easily found site search if desired. Vivisimo's VP of Marketing, Rebecca Thompson, gleefully mocked several big name brands for their unimpressive site search efforts.
Search Engine Crosses Canadian At Border
Canadian psychotherapist Andrew Feldmar had an unpleasant experience when he tried to cross the border into the U.S. last summer.
Yahoo Search Drops, As Does Its Stock
Yahoo gave away 0.6 percent of US search engine market share in March 2007, with Google and Microsoft gaining at Yahoo's expense by comScore's numbers. Higher expenses in the first quarter led to shares of YHOO sinking after hours.
Don't Hide Links From Matt Cutts
Sneaky people try all kinds of ways to hide links from visitors while showing the links to search engines, but one Matt recently discovered goes overboard in his opinion.
Map Those URL Redirects To Profit
There are right ways to do URL redirection that will make a big difference in one's site performance, as shown in a recent case study about a plumbing website that made their URLs more readable.
The Dilemma of Socially Driven Search
In a December 23rd posting, Wikipedia founder Jimbo Wales announced the re-focusing of efforts geared toward developing a socially driven search engine. Wikiasari (or Wikia for short) is poised to take a competitive posture toward the larger search engines such as Google and Yahoo, but is this really good for the industry?
Optimizing Pages for Link or Profit Potential
Each web page can be optimized for conversion or linkability, but few pages are well optimized for both. That is part of why search as a business model works so well. The signals of quality that search engines look for are typically associated with information, not pages that convert well, thus those who have overtly conversion oriented sites and pages have to buy advertising.
Yahoo! Directory Registration
SEO Question: Is a Yahoo! Directory registration worth it? How do I know what directories are worthwhile? What directories should I submit to? Do you have any good site submission tips?
SES Chicago Day .05
Thomas (TwisterMC) and I arrived fine in Chicago without delay. Unlike many other travelers, including Shoemoney who I talked to about a 4+ hour delay.
Search Engine Strategies Chicago
Later this afternoon Thomas and I will fly out to Search Engine Strategies in Chicago where I'll be covering some sessions, doing more video interviews, taking lots of photos and the best parts: learning and networking. I will also be sitting in on the Social Media Optimization panel with Neil, Rand, Andy and Todd.
New Search Engine Marketing Certification Choices
As demand increases for skilled workers in the search engine optimization and search engine marketing industries, more educational options have become accessible during 2006. The latest option is called "Certification Pathways", offered by the Search Engine College
What Comes Next For Search Engine Watch?
Danny Sullivan had announced some time back that he will be starting a new SEO blog: Search Engine Land.
Podzinger Rocks
When was the last time a search engine made you say, "Wow"?
Demystifying Your Competitor's Ranking Successes
We have all been there, "how the heck do they always get #1?" It is a constant frustration for many a client and, well, even myself occasionally.
Source Code Needs A Place To Stay
This isn't a chapter in the CVS versus Subversion debate, but a look at places online to view useful pieces of code.


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Stingray 220 LxBoats for sale - 7 found
2005 Stingray Boats 220 LX, Very clean one owner boat in excellent condition with tandem axle(877) 521-1704 2 weeks ago on Sweetwater Performance Center
The Stingray 220 LX is a sleek open bow with the performance of a sportboat. 5.7 300hp mercruiserOver 1 month ago
2007 STINGRAY Mercruiser 5.0 Liter 260 HORSEPOWER Garmin 441 GPS CD/Am fm radio Trim Tabs NewOver 1 month ago
22 ft long, 8 ft 1 in beam, 350 hp mercruiser engine cruises at over 50 mph, tows skis, toys, easily. engine has less than 30 hours on it. seats 10 people. $8800 cash only. have clear title. no pay pal. have had boaOver 1 month ago
I'm selling my 2002 Stingray with about 240 hrs. This boat has been a lot of fun and very reliableOver 1 month ago
Equipped with a MerCruiser 4.3LX/V6, 220HP I/O & cover. - 1993 Stingray 606 Bowrider with coverOver 1 month ago
Alpha 1 Out DriveHorse Power:?220 HPOut drive equipped with a Stingray. Gets this boat on plane quicklyOver 1 month ago
Craigslist.org is no longer supported.


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If you wish to register the image, suggest you collect digital images and make a collective singular file with all images combined. This will save you money as you could have 20 or 30 images in one and by registering the lot as a singular work of multiple images you are registering all images.
Commercial photography has basically 2 work conditions. (1) photographer retains rights (negatives) therefore your client theoretically should return for more prints. Image can not be used by anyone else. (2) "Buyout" client pays extra, maybe double, and receives negatives and all media created. You may have the right to use the imagery to promote your business but that is where it probably ends.
Possession is 9/10's the law. Unfortunately clients do not always see it that way and feel they can do anything they want with it, and usually do. Problem is if you want them to remain a client do you make a stink about it? Typically I like the buyout. I make more money
and usually the negatives will get mishandled and become unusable, or lost. Where do you think they will go.
Any digital image of a print that I put on the web I put a copyright on it. People, especially polliticians love to surf looking for images for campaign flyers, etc. (gotcha) Whether you register now or when the infraction takes place it should not matter. Internet law has a "fair use" clause whereby you can copy the image as long as it is not going to be used for financial benefit, or used to denigrate a person, business, culture, etc. publicly.


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Tel: (304)232-0361
90 students
Private for-profit
Private for-profit
West Virginia Business College, Inc. is a private co-educational institution incorporated under the laws of the state of West Virginia.
School Highlights:
West Virginia Business College-Wheeling serves 90 students (100.00% of students are full-time).
The college's student:teacher ratio of 18:1 is lower than the community college average of 24:1.
Minority enrollment is 2% of the student body (majority Black), which is more than the state average of 14%.
School Overview
The teacher population of 5 teachers has stayed relatively flat over five years.
|West Virginia Business College-Wheeling
|Community College Avg.
|Carnegie Classification
|Associate of Arts Colleges
|Associate of Arts Colleges
|Institution Level
|At least 2 but less than 4 years
|At least 2 but less than 4 years
|Institution Control
|Private for-profit
|Total Faculty
|5 staff
|61 staff
|Total Enrollment
|90 students
|1,296 students
|Student : Teacher Ratio
|# Full-Time Students
|90 students
|815 students
|% Black
|% White
|Diversity ScoreThe chance that two students selected at random would be members of a different ethnic group. Scored from 0 to 1, a diversity score closer to 1 indicates a more diverse student body.
School Notes:
- West Virginia Business College a long established private institution founded in 1881, nationally accredited and locally owned. WVBC is a co-educational institution offering diploma and specialized associate degree programs. The Wheeling Campus, at 1052 Main Street, is conveniently located in regard to restaurants, parking facilities and public transportation. WVBC occupies a modern 11,000 square feet, multi-level building to meet the needs of the student body. A branch campus is located in Nutter Fort, WV to serve central WV. West Virginia Business College offers a variety of programs ranging in length from nine months to eighteen months. Diploma Programs are offered in Business Management/Accounting Program, Secretarial Sciences/ Executive Secretary, Secretarial Sciences/ Legal Secretary, Secretarial Sciences/ Medical Secretary, Computer Applications/ Accounting and Computer Applications/ Secretarial. Specialized Associate Programs includes Office Administration/Executive Secretary, Office Administration/Medical Assistant, Office Administration/Medical Secretary. West Virginia Business College is accredited by the Accrediting Council for Independent Colleges and Schools to award Diplomas and Specialized Associates Degrees.
Nearby Schools:
- College Location Mi. Students
Wheeling1704 Market St.
Wheeling, WV 26003
(304)233-59000.43 Mi | 2,050 students
Saint Clairsville120 Fox Shannon Place
Saint Clairsville, OH 43950
(740)695-950012.87 Mi | 1,283 students
Saint Clairsville45425 National Rd W
Saint Clairsville, OH 43950
(740)695-172013.38 Mi | 1,093 students
Steubenville4000 Sunset Blvd
Steubenville, OH 43952
(740)264-559121.41 Mi | students
Washington242 Oak Spring Road
Washington, PA 15301
(724)222-533026.86 Mi | 382 students
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Arizona House Speaker Kirk Adams Airs Series About Budget Crisis on YouTube
State House Speaker Kirk Adams, a Mesa Republican, has launched a series of YouTube videos that explain Arizona's budget crisis -- from the point of view of Republican legislators like him, of course.
Sonoran Alliance, (where we first read about the videos), calls the series a public-relations offensive. Adams has apparently decided Governor Jan Brewer, who has her own solution to the budget problems, has been getting more than her fair share of attention. But Adams' deadpanned rhetoric is tougher to watch than a late-night infomercial, so you're probably better off reading this short summary of his message.
In any case, the videos can't match the kind of publicity you can get from, say, TV news. The first video in the series, the one entitled "Arizona's Economic Crisis," is the most watched, having been seen 301 times as of Wednesday morning. In it, Adams explains that "it's time to adjust our spending for the income coming into state coffers." Simply put, the state "must not spend more than it has."
In "Arizona's Future," Adams reminisces about hardscrabble pioneers and says Arizonans, in the long run, must "grow our way out" of financial problems.
Another video has Adams describing the differences between Brewer's budget plan and the one passed by a faction of Republican lawmakers earlier this month -- namely, that she wants a tax increase and the lawmakers don't.
The situation is more complicated than Adams wants his YouTube viewers to know. According to one Republican lawmaker who voted against the budget bill, Bill Konopnicki, the idea that Adams and crew passed a "balanced budget" is a sham, because it uses every accounting "gimmick and game" in the book and the projected money shortfall is disputed:
The proposed House/Senate budget that passed accounts only for a $3 billion revenue shortage, while the governor's budget office has calculated the shortage to be $4 billion. If Arizona loses the stimulus money, the shortage will be $5 billion. It is not fair to play games with the citizens of Arizona and let them think that the Legislature passed a balanced budget when, in fact, it is not a balanced budget.
In his video, "Difference in Budget Proposals," Adams doesn't address the $1 billion discrepancy in projected shortfalls. But he does say it would be "irresponsible" of Brewer to veto the budget bill because it might cause a government shutdown.
We'll know who's right in this battle of the budgets only after we see the real -- and possibly really ugly -- effects on Arizona's residents.
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The morally ambiguous second volume in Lukyanenko's trilogy (after 2006's Night Watch, a major literary and cinematic success in Russia) portrays the epic supernatural struggle between good and evil from the point-of-view of the witch Alisa Donnikova. Lukyanenko imagines a parallel reality, where human history has been shaped by a centuries-old conflict between the Dark Ones and the Light Ones, magical beings whose existence is kept carefully hidden from humanity. After Alisa, a Dark One, loses her powers in a minor confrontation with some Light Ones, she heads to the Crimea to recuperate at a girls' camp, where she feeds on children's nightmares. There she falls in love with Igor, who turns out to be a Light magician. The plot centers on the ramifications of their romance and the theft of Fafnir's Talon, a powerful artifact whose provenance is linked to the legendary Ring of the Nibelungs. Though the artifact conceit is less well developed than that of the truth-telling instrument in Philip Pullman's His Dark Materials series, the fast-paced story augurs well for the last installment. (Mar.)Copyright 2006 Reed Business Information.
Day Watchby Sergei Lukyanenko
View All Available Formats & Editions
The second book in the internationally bestselling Night Watch series—the powers of Darkness and the forces of Light grow closer to war.
Tor the past one thousand years, the two factions of the Others—an ancient race of magicians, shape-shifters, vampires, and other supernatural beings—have been locked in an uneasy truce as the powers of… See more details below
The second book in the internationally bestselling Night Watch series—the powers of Darkness and the forces of Light grow closer to war.
Tor the past one thousand years, the two factions of the Others—an ancient race of magicians, shape-shifters, vampires, and other supernatural beings—have been locked in an uneasy truce as the powers of Darkness and the forces of Light secretly maneuver for the upper hand.
Now in the thrilling follow-up to the internationally bestselling Night Watch, we track members of the Dark Others—called the Day Watch and tasked with keeping the Light Others in check—including a young witch who has had the tragic misfortune of falling in love with a Light Other; a powerful warlock struggling to understand his purpose in the war; and a top lieutenant who worries that Zabulon, the leader of the Day Watch, is planning to betray him. Meanwhile, a forbidden artifact with the ability to bring the most dangerous Dark magician in history back to life has gone missing.
As the inevitable war between the forces of Darkness and Light threatens to destroy modern-day Moscow, it becomes clear that good and evil are only a matter of perspective.
Editorial Reviews
Product Details
- 9780062310118
- Publisher:
- HarperCollins Publishers
- Publication date:
- 01/21/2014
- Series:
- Sergei Lukyanenko's Night Watch Series, #2
- Pages:
- 480
- Sales rank:
- 261,552
- Product dimensions:
- 5.31(w) x 8.00(h) x 0.76(d)
- Age Range:
- 13 - 18 Years
Read an Excerpt
The entrance did not inspire respect. The coded lock was broken and not working, the floor was littered with the trampled butts of cheap cigarettes. Inside the lift the walls were covered with illiterate graffiti, in which the word 'Spartak' figured as often as the usual crude obscenities; the plastic buttons had been burned through with cigarettes and painstakingly plugged with chewing-gum that was now rock-hard.
The door into the apartment on the fourth floor was a good match for the entrance: some hideous old kind of Soviet artificial leather, cheap aluminium numbers barely held up by their crookedly inserted screws.
Natasha hesitated for a moment before she pressed the doorbell. She must be insane to hope for anything from a place like this. If you were so crazy or desperate that you decided to try magic, you could just open the newspaper, switch on the TV or listen to the radio. There were serious spiritualist salons, experienced mediums with internationally recognised diplomas . . . It was all still a con, of course. But at least you'd be in pleasant surroundings, with pleasant people, not like this last resort for hopeless losers.
She rang the bell anyway. She didn't want to waste the time she'd spent on the journey.
For a few moments it seemed that the apartment was empty. Then she heard hasty footsteps, the steps of someone in a hurry whose worn slippers are slipping off their feet as they shuffle along. For a brief instant the tiny spy-hole went dark, then the lock grated and the door opened.
'Oh, Natasha, is it? Come in, come in . . .'
She had never liked people who spoke too familiarly from the very first meeting. There ought to be a little more formality at first.
But the woman who had opened the door was already pulling her into the apartment, clutching her unceremoniously by the hand, and with an expression of such sincere hospitality on her ageing, brightly made-up face that Natasha didn't feel strong enough to object.
'My friend told me that you . . .' Natasha began.
'I don't know, I don't know about that, my dear,' said her hostess, waving her hands in the air. 'Oh, don't take your shoes off, I was just going to clean the place up . . . oh, all right then, I'll try to find you a pair of slippers.'
Natasha looked around, concealing her disgust with difficulty.
The hall wasn't so very small, but it was crammed incredibly full. The light bulb hanging from the ceiling was dull, maybe thirty watts at best, but even that couldn't conceal the general squalor. The hallstand was heaped high with clothes, including a musquash winter coat to feed the moths. The lino of the small area of floor that could be seen was an indistinct grey colour. Natasha's hostess must have been planning her cleaning session for a long time.
'Your name's Natasha, isn't it, my daughter? Mine's Dasha.'
Dasha was fifteen or twenty years older than her. At least. She could have been Natasha's mother, but with a mother like that you'd want to hang yourself . . . A pudgy figure, with dirty, dull hair and bright nail varnish peeling from her fingernails, wearing a washed-out house coat and crumbling slippers on her bare feet. Her toenails glittered with nail varnish too. God, how vulgar!
'Are you a seer?' Natasha asked. And in her own mind she cried: 'What a fool I am.'
Dasha nodded. She bent down and extracted a pair of rubber slippers from a tangled heap of footwear. The most idiotic kind of slippers ever invented — with all those rubber prongs sticking out on the inside. A Yogi's dream. Some of them had fallen off long before, but that didn't make the slippers look any more comfortable.
'Put them on!' Dasha suggested joyfully.
As if hypnotised, Natasha took off her sandals and put on the slippers. Goodbye, tights. She was bound to end up with a couple of ladders. Even in her famous Omsa tights with their famous Lycra. Everything in this world was a swindle invented by cunning fools. And for some reason intelligent people always fell for it.
'Yes, I'm a seer,' Dasha declared as she attentively supervised the donning of the slippers. 'I got it from my grandma. And my mum too. They were all seers, they all helped people, it runs in our family . . . Come through into the kitchen, Natasha, I haven't tidied up the rooms yet . . .'
Still cursing herself for being so stupid, Natasha went into the kitchen, which fulfilled all her expectations. A heap of dirty dishes in the sink and a filthy table — as they appeared, a cockroach crawled lazily off the table-top and round under it. A sticky floor. The windows had obviously not been spring-cleaned and the ceiling was fly-spotted.
'Sit down.' Dasha deftly pulled out a stool from under the table and moved it over to the place of honour — between the table and the fridge, a convulsively twitching Saratov.
'Thank you, I'll stand.' Natasha had made her mind up definitely not to sit down. The stool inspired even less confidence than the table or the floor. 'Dasha . . . That's Darya?'
'Yes, Darya.'
'Darya, I really only wanted to find out . . .'
The woman shrugged. She flicked the switch on the electric kettle — probably the only object in the kitchen that didn't look as if it had been retrieved from a rubbish tip. She looked at Natasha.
'Find out? There's nothing to find out. Everything's just as clear as can be.'
For a moment Natasha had an unpleasant, oppressive sensation, as if there wasn't enough light in the kitchen. Everything went grey, the agonised rumbling of the refrigerator and the traffic outside on the avenue fell silent. She wiped the icy perspiration from her forehead. It was the heat. The summer, the heat, the long journey in the metro, the crush in the trolleybus . . . Why hadn't she taken a taxi? She'd sent away the driver with the car — well, she'd been embarrassed to give anyone even a hint of where she was going and why . . . but why hadn't she taken a taxi?
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March 19, 2012
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National Day of Prayer tomorrow
Join members of the community for the annual National Day of Prayer observance at noon tomorrow on the Spencer County Courthouse steps. In case of bad weather, we will meet at First Baptist Church in Taylorsville. Several local leaders will participate this year as we share in singing and praying for our nation. Pastors from many churches will pray for our government, for our military, for the media, for business, and for many other aspects of our life together. Please come and take an hour out of your day to pray for America. The National Day of Prayer is an annual observance held on the first Thursday of May, inviting people of all faiths to pray for the nation. It was created in 1952 by a joint resolution of the United States Congress, and signed into law by President Harry S. Truman.
Honor service for Armed Forces
There will be an honor service at Risen Lord Lutheran Church, located at 5138 Taylorsville Road, at 10 a.m. May 9. Members of our armed forces sacrifice and selflessly serve for you and our country. Please take an hour to come out and honor them and their families. There will be military guest speakers, refreshments, and a special memorial for Kentucky's fallen heroes. This event is presented by Guard Duty, Inc., a non-profit organization honoring God and County.
Fund-raiser for Little Union
Ron Blackwood and the Legendary Blackwood Quartet will be performing Saturday at 7 p.m. at the Spencer County Middle School Gym, 1263 Mt. Washington Rd. Tickets are $12 in advance or $15 at the door. For tickets and information contact: (502) 252-7051. All proceeds will benefit the Little Union Baptist Church building fund.
Revival at Grace Chapel
Revival services will be held at Grace Chapel, 60 Ray Rd., at 7 p.m. May 15 and May 16, and at 6 p.m. May 17. Bishop R.L. Smith will be the evangelist. Everyone is welcome to attend.
Corn Hole Tournament at
Finchville Baptist
Finchville Baptist Student Ministries presents Family Fun Day featuring their 1st Annual Corn Hole Tournament, Saturday, May 16. Fun for the whole family! Playground Inflatable, Cake Walks, Raffles, Concessions, and Corn Hole! Tournament check-in at 9 a.m. with first toss at 10 a.m. Cash prizes awarded to 1st, 2nd, and 3rd place winners! Visit www.finchvillebaptist.com for more details and registration.
Dave Ramsey
offers Biblical
financial advice
Sunday night at 6 p.m. May 17 at Elk Creek Baptist Church. This is a three-week video driven series by Financial Expert Dave Ramsey. Topics covered include: The Basics of Biblical Finance, Breaking the Bondage of Debt, & The #1 Myth about Money. A discussion group will meet at 7 p.m. the Wednesday following each session to further discuss the topics covered. For more info, call 477-2730.
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I have eaten at Ruth's Chris many times over the years and you just can't go wrong, especially for special occasion. TRY the Cheese Cake you will top off a fine meal with awesomeness.
This was our first trip to a Ruth's Chris Steak House because we always thought the prices were way too high for it to be worth it! Well, we were amazed at the superior quality of the food and the service, but STILL think it's way overpriced. None of your side items come with the entree; everything is ala carte, so be prepared if you go. BUT if you're in the mood to splurge and spoil your partner, THIS is the place because you will NOT leave hungry nor disappointed at the quality of the food and service!
We had great service here. We were celebrating a birthday and an anniversary at our table, and they brought out fancy desserts for us! We felt very special. Overall everything was excellent. We ordered a baked potato to share and they served it on two plates, a nice touch. It was our first visit to a Ruth's Chris and we were glad we tried it. The only thing I didn't get was the hot plate the steak was served on. By the time I could finish mine, it had continued to cook until it was dry and overdone.
The service was top-notch and the food was even BETTER! Went there to celebrate a friend's birthday, and we both thoroughly enjoyed!!! Even though it is inside a casino, the atmosphere was elegant and fun...and the food was absolutely divine!
Best filet ever! Great atmosphere! Great location - inside Hard Rock Casino! Great service! Oh, did I mention the best filet ever - cooked to perfection, delivered with perfection and devoured as best I could! Yum.
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Fix for Campaign loading
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Lookalikes of Prince William and a pregnant Kate Middleton faked out the London media on Friday.
The New Orleans Saints are back in the Mercedes-Benz Superdome for yet another game in hopes of obtaining their first win of the season.
St. Lucie County Sheriff's Department
His profile rose again, for the wrong reasons, thanks to a November 2010 DUI arrest in Florida.
Former "Partridge Family" star David Cassidy has been charged by authorities in Florida with leaving the scene of a traffic accident last month.
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The Charms of City Boating
Baltimore Marine Center's Boatel at Pier 7 has space for 84+ boats in a large modern facility, with a staff trained to accommodate your needs!
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Baltimore's Inner Harbor is home to wonderful restaurants, museums, shopping, site-seeing, night life, and so much more. Here's a list of several area attractions:
Oct 26 1:00 PM - 3:00 PM
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Corruption in sport - why a global problem requires a global solution
Why should sports governing bodies take allegations of corruption seriously? Lessons from the FIFA investigations
FIFA arrests: it's all kicked off, but what's next? A legal perspective
First International Forum for Sports Integrity adopts roadmap for future action to protect clean athletes
Le premier Forum international pour l'intégrité du sport adopte une feuille de route pour la protection des athlètes intègres
Tackling match-fixing: a look at the UK's new Anti-Corruption Plan
IPL 6 hearings continue with allegations against Srinivasan
Whistleblowing in Sport – Part 2: Investigations and Disciplinary Proceedings
Integrity in Sport Update: New Zealand pass Crime Match Fixing Amendment Bill
Weekly Media Recap 1-7 December 2014
Match-fixing case law update: important lessons from Olaso, Blake and Vanakorn
US sports betting: why statutory interpretation may be key to New Jersey's efforts to legalize gambling
An overview of the latest match-fixing policy developments in 2015
What does March Madness betting tell us about the integrity of US college basketball?
IPL 6 Scandal: Supreme Court hears conflict of interest arguments
Integrity In Sport Update: two footballers banned for life for match-fixing
Weekly Media Recap 8-14 December 2014


text: Home > Hot Girls > Hump Day Hotties Hump Day Hotties Pony July 8, 2009 Hot Girls No Comments Hump Day Hotties once again help make the week seem a bit shorter. I like to think of today as the day where you an look ahead and see that 5PMwhistle on Friday night. Monday and Tuesday are distant memories because you have these hotties to admire today. Tori Thompson predicts the UFC100 Cindy Crawford will always be hot Tags:amateurs, bikini, lingerie, sexy Related Posts Alicia Keys is R&B Sexy Danielle Sharp is Super Tata Thursday Maiken Skoie Brustad Best Butts


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Bradley, you missed the point. Most of the people I know are honest and display the utmost integrity. History is not black and white as you know and there are always grey areas especially when variuos people claim different things. I respect your opinion regarding the ability of politicians Israeli or other to not tell the absolute truth, but that still does not make all Israeli's or all Arabs for that matter liars. I still feel this type of article is damaging. If you are a patriot, you should make clear distinctions instead of generalizations
from the article: How to tell when a Mideast Expert is lying


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Disney Channel Baby Names
Simple and universal, Marco is a Latin classic that would make a much livelier namesake for an Uncle Mark. It was used for her son by actress Jill Hennessy, and goes well with any straightforward s... Read More
Well over two thousand parents chose this ancient Roman name for their sons in the last year recorded, some perhaps honoring Marcus Garvey, leader of the Back to Africa movement. Though ancient, Ma... Read More
Mason has become mega-popular, hitting the Number 2 spot in 2011, by far the highest its ever been on the Social Security list, and still in the Top 5 at Number 3. Mason is an occupational surname... Read More
Though it's close to the German and French form of Matthew, Mathis, this name of the great artist can work as well for girls. Read More
Lovely name familiar in several Asian cultures. Read More
One-time overnight success name, thanks to Hannah Montana actress and singer Miley Cyrus. Miley was a childhood nickname (because she was so smiley); Destiny is her real name. Read More
Milo has long been a highly recommended author favorite, now getting some well deserved appreciation. Milo combines the strength of the ancient Greek Olympic wrestler of that name--a six-time winn... Read More
Nico is one of the great nickname names, full of charm, energy and sex appeal--a neo Nick. It has risen 95 places in the past year, one of the ten highest risers on the boys' list in 2011. Nico is... Read More
Nova is a name that has the feel of both newness, from his meaning, and great energy from being an astronomical term for a star that suddenly increases in brightness, then fades. Now making somet... Read More
Just when we had written off Peggy as the eternal perky, pug-nosed prom-queen she projected from the 1920s into the fifties, along came Mad Men , with intriguing mid-century characters with names ... Read More
You might also like these lists:
- Yupster Baby Names for Girls Includes: Juliet, Tess
- Halloween Baby Names Includes: Wednesday, Jett
- Place Names for Babies Includes: London
- Vowel Baby Names for Girls Includes: Ivy
- Vintage Baby Names for Boys Includes: Phineas
- 1990s Baby Names Includes: Jesse, Cody
- If You Like Nicholas, You Might Love... Includes: Marcus, Milo, Nico
- Classic Baby Names with a Twist Includes: Marco, Nico
- If You Like Braden, You Might Love... Includes: Mason
- If You Like Lucy, You Might Love... Includes: Ivy


text: Christopher Furlong, Getty Images [ Should LISD go to School Uniforms? [POLL] By Chad Hasty February 27, 2012 LISD is thinking about going to school uniforms in some schools. What do you think? Read More|Comment Category: Polls Tags: Education, LISD Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


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A Dialogue on Effective AssessmentMore Related Discussions
This post was created by a member of Edutopia's community. If you have your own #eduawesome tips, strategies, and ideas for improving education, share them with us.
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Hi John,
We just released a Schools That Work feature on the topic of assessment with School of the Future. (http://www.edutopia.org/stw-assessment) We also have the Live Chat with Andy Synder after discussion (http://www.edutopia.org/groups/assessment/40281). Please join in on the discussion!
We can also use this forum to discuss effective assessment. It might also be good to construct a handbook of different types of assessment that people can peruse and examine and add to, perhaps a wiki?
A Wiki or Google doc might be a good start for getting a collaboration started. I like to think that the most effect assessments also teach students content and 21st-century skills as they take them.
Recently I gave my US History students a test, because I thought it would be appropriate to prepare them for taking tests in future Social Studies classes (something they will undoubtedly do). They had 10 key terms, and they had to choose 5 and identify who/what they were and why they were important. They also had to choose 2 essays and link historical facts to their opinion-based answers. I felt that if I was going to give a test, at least I would give one that includes big picture ideas and critical thinking skills.
To say they did terribly would be an understatement. Now, there were a variety of factors for this, including not having a test in my class before and having a number of snow days this year, but I believe that the extra opportunity to research and apply their knowledge from project-based learning pushes students' understanding over the edge.
I haven't seen anything out there which is a user-contributed wiki on assessment. It would be pretty interesting, I wonder if it is worth doing, if people would contribute. It certainly is fairly easy to set up.
Discussion What are Some Methods and Assessment Tools to Use in Special Education?Last comment 2 hours 11 min ago in Differentiated Instruction
blog Making Failure Harder Work Than PassingLast comment 2 weeks 7 hours ago in Teaching Strategies
blog Making Learning Meaningful and LastingLast comment 3 days 45 min ago in Teaching Strategies
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blog Starting the School Year With a PartyLast comment 1 month 2 weeks ago in Student Engagement


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Latest from the Blog
H&H Orlando welcomes veteran Amy Nicoletto
We had the privilege to talk with Amy Nicoletto from LA Ink about her upcoming guest spot at H&H Orlando starting July 15th.
Steve Oker is on a mission.
"I'll tattoo till I can no longer do it. I see myself staying in the industry forever." Steve's passion for tattooing is obvious to anyone who talks to him.


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The breaches relate to the signing of Alejandro Faurlin, who allegedly was owned in part by a third party after moving to QPR.
Seven points clear at the top of the Championship, the club face a points penalty if found guilty and that could harm their hopes of promotion to the Premier League.
What is your opinion? Feel free to discuss the article under. You have to comment by using your Facebook profile. Be fair and have respect for other people and opinions!
Who of Europe's top strikers will move to England this summer?
After a dreadful start to their Bundesliga campaign, Borussia Dortmund appear to have weathered the storm after going five matches without defeat.