text:
XFX Radeon HD 7850 Black Edition 2GB Video Card Review - Benchmarks - Metro 2033
Metro 2033
Version and / or Patch Used: Latest Steam Update
Timedemo or Level Used: Built in Benchmark
Developer Homepage: http://www.4a-games.com/
Product Homepage: http://metro.thq.com/
Metro 2033 is an action-oriented video game with a combination of survival horror and first-person shooter elements. The game is based on the novel Metro 2033 by Russian author Dmitry Glukhovsky. It was developed by 4A Games in Ukraine and released in March 2010 for Microsoft Windows and Xbox 360.[3] In March 2006, 4A Games announced a partnership with Glukhovsky to collaborate on the game.[4] The game was announced at the 2009 Games Convention in Leipzig;[5] a first trailer came along with the announcement.[6] A sequel was announced, currently titled Metro: Last Light.
Metro 2033 performance looks great and we see the performance increase helps move our 1920 x 1200 numbers from below 60 FPS to over 60 FPS. At 1680 x 1050 you can see our numbers look good while we also see a gain at 2560 x 1600, but unfortunately our numbers are too low to be playable at this high screen resolution.
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- Page 1 [Introduction and Package]
- Page 2 [The Card and Specifications]
- Page 3 [Benchmarks - Test System Setup]
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- Page 5 [Benchmarks - Unigine Heaven Benchmark]
- Page 6 [Benchmarks - Tom Clancy's H.A.W.X. 2]
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- Page 8 [Benchmarks - Lost Planet 2]
- Page 9 [Benchmarks - Aliens vs. Predator]
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text:
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subset: commoncrawl


text: Lakewood's Tent City as seen in the movie "Destiny's Bridge" (YouTube) [ Lakewood Tent City Being Dismantled [AUDIO] By Ilya Hemlin February 28, 2014 | Townsquare New Jersey Heavy equipment and construction crews are on hand to permanently tear down Tent City in Lakewood, as the encampment enters its final stages. Read More|Comment Category: News, Ocean County News Tags: Lakewood, newsletter, NJ, tent city Send to a friend! Share on Facebook Share on Twitter


text:
Add a splash of color to your living room with this jersey slipcover. It protects your furniture from stains or spills. Made of a blend of a polyester and spandex, this quick drying slipcover offers a stretch fit. Available for chairs, sofas, loveseats and pillows in a variety of colors.
Features: Stretch Fit
Protective Qualities: Quick-drying
Slipcover Fit Type: Stretch
Furniture Fit Measurements: Does Not Apply
Futon Size Fit: Does Not Apply
other Info.
- Made in the USA or Imported


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365-Day Returns... Hassle-Free!
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text:
Confidence intervals for median survival time with recurrent event data
Document typeArticle
Date issued2010-01
Rights accessRestricted access - publisher's policy
Several methods of constructing confidence intervals for the median survival time of a recurrent event data are developed. One of them is based on asymptotic variances estimated using some transformations. Others are based on bootstrap techniques. Two types of recurrent event models are considered: the first one is a model where the inter-event times are independent and identically distributed, and the second one is a model where the inter-event times are associated, with the association arising from a gamma frailty model. Bootstrap and asymptotic confidence intervals are studied through simulation. These methods are applied and compared using two real data sets arising in the biomedical and public health settings, using an available R package. The first example belongs to data from a study concerning small bowel motility where an independent model may be assumed. The second example involves hospital readmissions in patients diagnosed with colorectal cancer. In this example the interoccurrence times are correlated.
CitationGONZALEZ, J.; Peña, E.; Delicado, P. Confidence intervals for median survival time with recurrent event data. "Computational statistics and data analysis", Gener 2010, vol. 54, núm. 1, p. 78-89.
Aquest ítem (excepte textos i imatges no creats per l'autor) està subjecte a una llicència de Creative Commons: Attribution-NonCommercial-NoDerivs 3.0 Spain


text:
Sportsnet "Carl Hagelin has signed with the Anaheim Ducks, his new team, for four years. A restricted free agent acquired from the New York Rangers in exchange for Emerson Etem (draft picks also swapped hands) on June 27, Hagelin's new contract is worth a total of $16 million, according to Eric Stephens..." August 14
NHL.com "The New York Rangers acquired left wing Emerson Etem and the No. 41 pick in the 2015 NHL Draft from the Anaheim Ducks on Saturday for left wing Carl Hagelin and the 59th and 179th picks. Etem and Hagelin can become restricted free agents on July 1. The Rangers used the 41st pick to select..." June 28
Vigneault won't specify his lines, says he plans to "mix and match" Hagelin in his season debut off LTIR.
#NYR Second RFA signing this week as Carl Hagelin agrees to terms on a two-year deal. Deal is worth $4.5 million total, $2.25 AAV
CBS Sports "Two of the New York Rangers' top players may not be ready for the start of the 2013-14 regular season. The team announced Friday afternoon that forwards Ryan Callahan and Carl Hagelin both underwent surgery on Friday to repair torn labrums in their left shoulders. The team didn't announce an..." May 31
New York Post "Carl Hagelin didn't need 17 minutes to do what he couldn't do in 17 playoff games last season. The second-year Swede shook the weight of three playoff series off his shoulders just 16:44 into Game 1 of the Eastern Conference quarterfinals Thursday night, scoring his first career playoff goal..." May 03
New York Post "Carl Hagelin wasn't just in a scoring drought — the Rangers forward was in the desert, with no water in sight for miles. The speedy and gifted Swede failed to score in the Rangers' final 29 games last season and managed just one goal in the first 10 contests this year. In the last four,..." February 18


text:
active citizenship
Oxfam Sense Making Exercise for a Selection of Evaluations 2013-2014
This document reviews a sample of evaluations carried out between January 2013 and October 2014. The findings tell us about the nature of Oxfam's programming, helping identify strengths and weaknesses, and lessons, from our programs; the report includes remarks on our evaluation quality.
Somali Solutions
This report looks at Somali women's experiences with conflict, peace, violence, insecurity and state rebuilding
Ebola is Still Here
Oxfam has listened to women and men in Liberia and Sierra Leone to hear their priorities for the immediate response, the recovery and beyond.
Trying to solve poverty is a lot like trying to solve a really hard puzzle.
That's why Oxfam has a new six-sided strategy to tackle it, driven by the power of people against poverty.


text: Quick View A Brief History of Time by Stephen Hawking May 4, 2011 | Kobo Edition (eBook) $15.99 Available for download #1 NEW YORK TIMES BESTSELLER A landmark volume in science writing by one of the great minds of our time, Stephen Hawking's book explores such profound questions as: How did the universe begin—and what made its start possible? Does time always flow forward? Is the universe unending—or are there… See Details was


text:
2 Sisters Food Group
Food industry company news
Latest Insights
Comment: Act now to cut antibiotics in meat
All signs are pointing to a growing public awareness of – and concern about – the use of human antibiotics in animals that will subsequently...
Comment: Tread carefully over payment terms
Food manufacturers are catching some flack for extending payment terms to their suppliers. The growing tension in the supply chain points to...
| 5 Dec 2014
The fourth article in just-food's management briefing on food reformulation looks at competing priorities, in particular how the increased focus on salt and latterly sugar may mean less attention is paid to reducing fat, by both consumers and food companies.
| 24 Nov 2014
Kerry Group is reportedly mulling the sale of its frozen food business. The company has seen strong sales and profit momentum at its ingredients unit but endured a lacklustre performance from the consumer foods side of the business. In this context, it makes sense for the Irish company to pare down peripheral and under-performing areas of Kerry Foods. Katy Askew reports.
| 6 Aug 2014
The UK's Food Standards Agency has issued the results of its first set of quarterly campylobacter tests, part of a year-long study into the prevalence of the bacteria in the UK poultry supply. The results reveal that around three-fifths of chicken sold in UK supermarkets are contaminated with the bacteria and the regulator has conceded that more must be done to win over consumer trust. After a personal brush with the issue, having found offal in pre-packed supermarket chicken, Katy Askew would strongly concur.
| 24 Jul 2014
The meat supply chain is in the spotlight this week, with allegations in the UK and China of poor and potentially unsafe practices at firms supplying retail and foodservice giants including Tesco and McDonald's. But the entire industry needs to pay attention: consumer interest in what they eat is at its highest-ever level.
Latest News
| 23 Sep 2015
2 Sisters Food Group plans to invest GBP55m (US$84.2m) to support "further growth" at its own-label meal solutions unit by upgrading production.
| 21 May 2015
Asda is introducing a steam process, SonoSteam, to some of its chicken production in a move the retailer claims can reduce campylobacter contamination in fresh products by as much as 80%.
| 1 May 2015
This week, Mondelez International reported its first-quarter results, with news of a solid performance in China. Elsewhere, Associated British Foods announced the launch of a high-protein bread in New Zealand. Yves Potvin, founder of meat-free brand Gardein, spoke to just-food about its plans under the ownership of Pinnacle Foods. And Kerry Group said moves to reposition its portfolio to focus on snacking trends were paying off. Here is the week in quotes.
| 30 Apr 2015
2 Sisters Food Group, the UK food arm of Boparan Holdings, has announced plans to remove antibiotics defined by the World Health Organization as the "highest priority" and "critically important" to human health from poultry production.
| 21 Apr 2015
Two strikes planned this week at a Fox's Biscuits plant in Yorkshire have been suspended as staff mull a new pay offer from parent company 2 Sisters Food Group.
| 16 Apr 2015
2 Sisters Food Group has said it is in "dialogue" with union officials in the UK in a bid to avert a strike at a Fox's Biscuits plant.
| 16 Apr 2015
Engineers at a Fox's Biscuits plant in the UK are set to go on strike next week over what union officials have described as a "paltry and insulting" pay offer from the business.
| 31 Mar 2015
2 Sisters Food Group has announced a GBP10m investment at its Gunstones Bakery site in Dronfield in the UK.
| 17 Mar 2015
Boparan Holdings, the parent company of 2 Sisters Food Group, said it "stabilised" its business despite "another challenging quarter".
| 2 Mar 2015
2 Sisters Food Group has set out plans to cut around 80 jobs at its Fox's biscuits plant in Batley, West Yorkshire.
| 23 Feb 2015
2 Sisters Food Group started consultations with the union representing workers at its Llangefni poultry site this morning (23 February).
| 22 Dec 2014
US food giant Kraft Foods Group this week announced its chairman would also take on the role of CEO - and he promptly said the company would reassess its business to "stay ahead" of the "rapid change" within the industry.
| 18 Dec 2014
Boparan Holdings, the owner of 2 Sisters Food Group, revealed ongoing pressure on sales and margins during its first quarter.
| 18 Nov 2014
Boparan Holdings, the owner of UK company 2 Sisters Food Group, has reported annual higher losses after its bottom line was hit with restructuring charges.
| 21 Aug 2014
2 Sisters Food Group has confirmed jobs look set to go at two of the UK group's sites as contracts come to an end.
| 14 Aug 2014
The UK's Food Standards Agency has insisted no action will be taken against 2 Sisters Food Group, despite saying the poultry processor did breach hygiene regulations at one of its plant.
| 28 Jul 2014
2 Sisters Food Group said today (28 July) two plants at the centre of food safety allegations had passed audits ordered by the UK's Food Standards Agency.
| 25 Jul 2014
Poultry manufacturer 2 Sisters Food Group is facing a second investigation from the UK Food Standard Agency after health minister Jeremy Hunt ordered a probe into two of its plants.
| 15 Jul 2014
2 Sisters Food Group has confirmed the sale of its Solway Foods site in Corby to the same former executives that purchased its Avana Bakeries site in Newport, a deal announced last week.
| 10 Jul 2014
2 Sisters Food Group has announced the sale of the Avana Bakeries site in Newport to Food Utopia, a company set up by two former executives at the UK food group.
| 17 Jun 2014
2 Sisters Food Group has announced the appointment of former Findus Group CFO Stephen Leadbeater to the position of group CFO.
| 16 Jun 2014
Boparan Holdings, the parent company of 2 Sisters Food Group, has reported mixed third-quarter results, with higher underlying operating profit but the cost of closing sites hitting its bottom line.
| 15 May 2014
2 Sisters Food Group has remained silent on a report it has asked a number of banks for suggestions on how to strengthen the UK company's balance sheet.
| 12 May 2014
Burton's Biscuit Co. has refused to be drawn on a report it has approached the owner of Fox's Biscuits over buying its UK rival.
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| 5 Dec 2014
2 Sisters Food Group announced a new "multi million" pound bio-refinery deal with renewable energy experts H2 Energy this week. The plan is set to "transform the energy requirements" at 2 Sisters, the company said.
| 2 Sep 2013
Lucy Neville-Rolfe, the former Tesco executive, has accepted a role at 2 Sisters Food Group, one of the UK's largest food manufacturers.
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text:
The Prairie Heights varsity baseball team ran its season record to 5-0 with wins earlier this week over NECC foes Hamilton and Central Noble.
The students of Westview Elementary have been busy. In the past week they have collected over 145,000 aluminum cans.
At Tuesday's LaGrange County BZA meeting, a developmental standard variance for a deck was turned down.
It started with some "Singing in the Rain." And it's coming to a close with some "Little Women."
Prairie Heights High School has named Kara Gunthorp as valedictorian of the Class of 2013.
Dillon Henschen has been named salutatorian for his class.
Commissioners adopted an ordinance at Monday's meeting that will raise the fees for recording a deed.
The Lakeland School Board voted Monday to move ahead with plans for a new administration center for the corporation as they approved advertising for bids for construction.
Tonda Sutton
Chairperson of
Family Involvement
An Arbor Day program will take place from 4:30-5:30 p.m. on Friday, April 26, at ParGil Nature Center on SR 9 north of LaGrange.
Cindy B. Barrand, 58, Orland, Ind., died Tuesday, April 16, 2013 at Parkview LaGrange Hospital.
Celebrate the birth of a movement and help others in need by coming to donate blood in early May.
County Commissioners opted to re-think the CR 200N project which was approved at last week's county council/commissioner joint meeting.
The playing conditions were frigid, but Westview's bats were red-hot at Fremont Saturday morning.
Top-ranked (1A) Lakewood Park trimmed host Lakeland, 6-1 in varsity softball play last Friday night.
Lakeland downed NECC foe Hamilton (168-234) and Garrett (168-191) in varsity boys golf last Friday afternoon at Heron Creek Golf Course.


text:
Page 1
DOI: 10.1126/science.1120800
, 374 (2006); 311
et al.
Vanessa M. D'Costa,
Sampling the Antibiotic Resistome
www.sciencemag.org (this information is current as of October 1, 2007 ):
The following resources related to this article are available online at
version of this article at:
including high-resolution figures, can be found in the online Updated information and services,
can be found at: Supporting Online Material
found at:
can be related to this articleA list of selected additional articles on the Science Web sites
, 16 of which can be accessed for free: cites 22 articles This article
47 article(s) on the ISI Web of Science. cited by This article has been
6 articles hosted by HighWire Press; see: cited by This article has been
: subject collections This article appears in the following
in whole or in part can be found at: this article
permission to reproduce of this article or about obtaining reprintsInformation about obtaining
registered trademark of AAAS.
is a
2006 by the American Association for the Advancement of Science; all rights reserved. The title
Copyright American Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005.
(print ISSN 0036-8075; online ISSN 1095-9203) is published weekly, except the last week in December, by the
on October 1, 2007
Downloaded from
Page 2
with ORP), or that south polarity is character-
istic of a particular species that occurs at a
specific ORP.
The coexistence of magnetotactic bacteria
with north and south polarity in the same
chemical environment contradicts the current
accepted model of magnetotaxis, which states
that all magnetotactic bacteria in the Northern
Hemisphere swim north (downward in situ)
when exposed to oxidized conditions to reach
their preferred microaerobic or anaerobic
habitat. We observed that barbells with south
polarity and cocci with north polarity coexist
in microaerobic conditions in the water col-
umn. On the basis of this distributional pat-
tern, south polarity is clearly not used to
direct the barbell upward in the water column
toward higher oxygen levels. The current
model does not, therefore, provide any expla-
nation that can account for the existence of
south polarity.
This model implicitly assumes that polar-
ity observed in the laboratory under atmo-
spheric oxygen levels is equivalent to polarity
in situ. Our results suggest that this assump-
tion might be incorrect. Although the benefit
of north polarity in situ is clear for micro-
aerophilic magnetotactic bacteria, south po-
larity would have a clearly deleterious effect
by directing the bacteria away from their pre-
ferred chemical environment. There are rea-
sons to believe the behavior of magneotactic
bacteria in situ could differ from behavior
in the laboratory. Magnetotactic bacteria at
the chemocline of a stratified water column
rarely, if ever, experience atmospheric oxy-
gen levels like those in the standard labora-
tory assay for polarity. They also experience
chemical gradients (particularly of iron and
sulfur species) not present in a drop of water
exposed to air in the laboratory assay. It is
also possible that bacteria with north and
south polarity possess different chemo- or
redox-sensors that have opposite responses
to chemical concentrations out of the range
they typically experience. On the basis of
these results, new models are clearly needed
to explain the adaptive significance of mag-
netotaxis by magnetotactic bacteria in the
References and Notes
1. R. P. Blakemore, Annu. Rev. Microbiol. 36, 217 (1982).
2. R. P. Blakemore, R. B. Frankel, A. J. Kalmijn, Nature 286,
384 (1980).
3. J. L. Kirschvink, J. Exp. Biol. 86, 345 (1980).
4. S. Spring et al., Appl. Environ. Microbiol. 59, 2397
5. S. Spring, R. Amann, W. Ludwig, K.-H. Schleifer,
N. Petersen, Syst. Appl. Microbiol. 15, 116 (1992).
6. T. Sakaguchi, A. Arakaki, T. Matsunaga, Int. J. Syst. Evol.
Microbiol. 52, 215 (2002).
7. H. Petermann, U. Bleil, Earth Planet. Sci. Lett. 117, 223
8. J. F. Stolz, S.-B. R. Chang, J. L. Kirschvink, Nature 321,
849 (1986).
9. S. L. Simmons, S. M. Sievert, R. B. Frankel, D. A.
Bazylinski, K. J. Edwards, Appl. Environ. Microbiol. 70,
6230 (2004).
10. D. A. Bazylinski et al., Appl. Environ. Microbiol. 61, 3232
11. S. L. Simmons, K. J. Edwards, manuscript in preparation.
12. R. B. Frankel, D. A. Bazylinski, M. S. Johnson, B. L. Taylor,
Biophys. J. 73, 994 (1997).
13. R. P. Blakemore, D. Maratea, R. S. Wolfe, J. Bacteriol.
140, 720 (1979).
14. A. M. Spormann, R. S. Wolfe, FEMS Microbiol. Lett. 22,
171 (1984).
15. S. L. Simmons, K. J. Edwards, unpublished observations.
16. R. P. Blakemore, Science 190, 377 (1975).
17. T. T. Moench, W. A. Konetzka, Arch. Microbiol. 119, 203
18. Materials and methods are available as supporting
material on Science Online.
19. T. J. Lie, M. L. Clawson, W. Godchaux, E. R. Leadbetter,
Appl. Environ. Microbiol. 65, 3328 (1999).
20. R. Kawaguchi et al., FEMS Microbiol. Lett. 126, 277
21. E. F. DeLong, R. B. Frankel, D. A. Bazylinski, Science 259,
803 (1993).
22. A. J. Kalmijn, R. P. Blakemore, in Animal Migration,
Navigation, and Homing, K. Schmidt-Koenig, W. Keeton,
Eds. (Springer-Verlag, Berlin, 1978), pp. 354-355.
23. We thank P. Canovas and O. Rafie for field and lab
assistance; R. Frankel, E. Webb, and S. Sievert for input
on the manuscript; and K. Canter for use of a
magnetometer. S.L.S. was partially supported by a
National Defense Science and Engineering Graduate
Fellowship. This work was partially funded by grants to
S.L.S. and K.J.E. from the WHOI Reinhart Coastal Research
Center, the WHOI Ocean Venture Fund, and the WHOI
Ocean Life Institute. D.A.B. is supported by National Science
Foundation grant EAR-0311950. GenBank sequence
accession numbers for the sequences reported in this study
are as follows. Group 1: BL_G6, DQ322653; BL_H12,
DQ322658. Group 2, south-seeking bacterium: BL_C2c,
DQ322659; BL_E6c, DQ322660; BL_G11c, DQ322661.
Supporting Online Material
Materials and Methods
21 November 2005; accepted 20 December 2005
Sampling the Antibiotic Resistome
Vanessa M. D'Costa,1Katherine M. McGrann,1Donald W. Hughes,2Gerard D. Wright1*
Microbial resistance to antibiotics currently spans all known classes of natural and synthetic
compounds. It has not only hindered our treatment of infections but also dramatically reshaped
drug discovery, yet its origins have not been systematically studied. Soil-dwelling bacteria
produce and encounter a myriad of antibiotics, evolving corresponding sensing and evading
strategies. They are a reservoir of resistance determinants that can be mobilized into the
microbial community. Study of this reservoir could provide an early warning system for
future clinically relevant antibiotic resistance mechanisms.
resistance elements for self-protection that are
often clustered in antibiotic biosynthetic operons
(2, 3). Genes orthologous to these have been
identified on mobile genetic elements in resistant
pathogens in clinical settings. It has been sug-
ost clinically relevant antibiotics orig-
inate from soil-dwelling actinomy-
cetes (1). Antibiotic producers harbor
gested that aminoglycoside-modifying kinases
(4) and the alternate peptidoglycan biosynthetic
machinery that confers resistance to vancomy-
cin (5) probably originated in soil-dwelling anti-
biotic producers.
The presence of antibiotics in the environ-
ment has promoted the acquisition or indepen-
dent evolution of highly specific resistance
elements in the absence of innate antibiotic
production Esuch as vancomycin resistance in
Streptomyces coelicolor, Paenibacillus, and
Rhodococcus (6, 7)^. The soil could thus serve
as an underrecognized reservoir for resistance
that has already emerged or has the potential
to emerge in clinically important bacteria.
Consequently, an understanding of resistance
determinants present in the soil—the soil
resistome—will provide information not only
about antibiotic resistance frequencies but also
about new mechanisms that may emerge as
clinical problems.
We isolated a morphologically diverse col-
lection of spore-forming bacteria from soil
samples originating from diverse locations
(urban, agricultural, and forest). Strains that
resembled actinomycetes both morphologically
and microscopically were serially subcultured
to apparent homogeneity. Amplification and
sequencing of 16S ribosomal DNA from a
subset of strains indicated that they belonged
to the actinomycete genus Streptomyces, whose
species synthesize over half of all known
antibiotics (1). We constructed a library of
480 strains that was subsequently screened
against 21 antibiotics, including natural pro-
ducts (such as vancomycin and erythromycin),
their semisynthetic derivatives (such as mino-
cycline and cephalexin), and completely syn-
thetic molecules (such as ciprofloxacin and
linezolid). The antibiotics encompassed all
major bacterial targets (8) and included drugs
1Antimicrobial Research Centre, Department of Biochemistry
and Biomedical Sciences,2Department of Chemistry, McMaster
University, Ontario, Canada, L8N 3Z5.
*To whom correspondence should be addressed. E-mail:
20 JANUARY 2006VOL 311SCIENCEwww.sciencemag.org
on October 1, 2007
Downloaded from
Page 3
that have been on the market for decades as
well as several that have only recently been
clinically approved (such as telithromycin and
The screen was conducted at high antibiotic
concentrations (Fig. 1), and strains of interest
were analyzed by determination of the minimal
inhibitory concentration (MIC). A subset of
isolates was characterized on the basis of mode
of resistance in order to distinguish resistance
arising from antibiotic alteration or modification
from that arising from nondestructive mech-
anisms (such as efflux, altered target, or trans-
port) (Table 1).
Without exception, every strain in the
library was found to be multi-drug resistant to
seven or eight antibiotics on average, with two
strains being resistant to 15 of 21 drugs (Fig.
1B). Reproducible resistance to most of the
antibiotics, regardless of origin, was observed,
and almost 200 different resistance profiles
were seen (Fig. 1, A and C), exemplifying the
immense genetic and phenotypic diversity of
the collection of bacteria.
Several antibiotics, including the synthetic
dihydrofolate reductase (DHFR) inhibitor tri-
methoprim and the new lipopeptide daptomy-
cin, were almost universally ineffective against
the library. The genomes of S. coelicolor
and S. avermitilis do not contain annotated
DHFR genes, which is consistent with insen-
sitivity to trimethoprim (9). However, exten-
sive daptomycin resistance was not anticipated.
Recently approved by the Food and Drug
Administration (FDA), daptomycin is high-
ly active against Gram-positive bacteria, in-
cluding multi-drug–resistant pathogens (10, 11).
A member of a large antibiotic class com-
monly produced by actinomycetes, daptomy-
cin is thought to act by insertion into the
bacterial cell membrane in a Ca2þ-dependent
manner (12, 13).
Eighty percent of the resistant strains assayed
inactivated daptomycin after 48 hours of cell
growth, while the remaining strains retained ac-
tive antibiotic in the culture media (Table 1).
This finding is notable not only because it is
only the second documented occurrence of
daptomycin inactivation (14) but because of its
unprecedented high frequency. Furthermore, it
suggests that there are multiple mechanisms of
daptomycin resistance in soil organisms.
We uncovered a wealth of inactivating en-
zymes produced by soil bacteria. Of the 11
antibiotics screened, bacterial isolates were
detected that putatively metabolized 6 drugs
(Table 1), including rifampicin and Synercid.
Rifampicin, a semisynthetic derivative of a
natural Amycolatopsis mediterranei product, is
central to the treatment of mycobacterial in-
fections. Forty percent of resistant isolates were
capable of inactivating the drug, which is
intriguing because clinically, the most prevalent
mechanism of rifampin resistance is through
point mutations in the target: RNA polymer-
ase_s b subunit.
Synercid, which was FDA-approved in
1999 for the treatment of drug-resistant bacte-
remia, is a combination of two semisynthetic
derivatives of Streptomyces metabolites, each
with a distinct mode of action. Eighteen percent
of resistant isolates tested were able to detoxify
both antibiotics. These findings collectively re-
inforce the importance of enzymatic antibiotic
inactivation as a means of resistance (4).
The screen yielded five strains that were
highly resistant to the glycopeptide vancomycin
(MICs of 128 to 256 mg/ml). Resistance in both
clinically significant and glycopeptide-producing
Fig. 1. Antibiotic resistance profiling of 480 soil-derived bacterial isolates. (A) Schematic diagram
illustrating the phenotypic density and diversity of resistance profiles. The central circle of 191 black
dots represents different resistance profiles, where a line connecting the profile to the antibiotic
indicates resistance. (B) Resistance spectrum of soil isolates. Strains were individually screened from
spores on solid Streptomyces isolation media (SIM) against 21 antibiotics at 20 mg of antibiotic per ml of
medium (mg/ml). Resistance was defined as reproducible growth in the presence of antibiotic. (C) Resistance
levels against each antibiotic of interest.
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bacteria is the result of the biosynthesis of an
altered peptidoglycan terminating in D-alanine-
D-lactate rather than D-alanine-D-alanine, result-
ing in a poor binding affinity to vancomycin.
This mechanism is encoded by a cluster of three
genes, vanH-vanA-vanX, which can be readily
identified by polymerase chain reaction analysis
in resistant Streptomyces (5). Using this strategy,
the cluster was amplified in 80% of resistant
strains (fig. S1). The outlying strain AA#4 ap-
peared to be resistant by a nondestructive
mechanism and displayed a distinct glycopeptide
resistance profile. Although the vanHAX strains
demonstrated vancomycin resistance (MICs of
128 to 256 mg/ml) but sensitivity to the lipo-
glycopeptide teicoplanin (MICs of 1 to 4 mg/ml),
AA#4 was resistant to both (MICs of vancomy-
cin and teicoplanin of 256 mg/ml).
Synthetic fluoroquinolones target DNA
gyrase A (GyrA)–dependent supercoiling and
topoisomerase IV–dependent decatenation of
bacterial DNA, inhibiting DNA replication
and segregation (15, 16). Clinical resistance oc-
curs primarily through point mutations in the
N-terminal region of gyrA, termed the quinolone
resistance–determining region (QRDR) (17);
however, resistance has also been documented
through antibiotic efflux (17) and plasmid-
mediated protection of DNA gyrase (18).
Despite a lack of known prior exposure to
fluoroquinolones or bacterially synthesized
analogs, 11% of strains demonstrated intrinsic
resistance to ciprofloxacin (Fig. 1C, MICs of 6
to 128 mg/ml). Of the 52 resistant strains, none
eliminated fluoroquinolone antibacterial activi-
ty, indicating that enzymatic inactivation was
unlikely (Table 1). To investigate the possibility
of QRDR mutation, this region was cloned and
sequenced from 38 resistant isolates (Fig. 2).
Eleven different amino acid substitutions were
identified at nine QRDR locations in 24% of
strains sequenced. These included locations
commonly associated with clinical ciprofloxacin
resistance (such as Ser83and Asp87, using the
Escherichia coli numbering system), as well as
novel sites within the QRDR (such as Met100
and Ser110). Among these strains, the isolate
with the highest MIC displayed a mutation at a
novel location (Ser110). The high incidence of
mutations in the absence of obvious environ-
mental selective pressures is consistent with
Fig. 2. ProteinsequencealignmentoftheQRDRofciprofloxacin-resistantstrainsexhibitingmutations.
A 266–base pair region of gyrA was amplified in resistant strains and sequenced. Mutations are labeled
in orange, and residues are numbered according to the E. coli system. Black sites are completely
conserved among the 38 strains sequenced, blue sites display 80 to 99% identity, and green sites
demonstrate 60 to 80% sequence identity. A white background represents amino acids not displaying
similarity with their wild-type counterpart. Sites labeled with a star are novel with respect to mutations.
The corresponding MICs of ciprofloxacin are indicated at the left.
Table 1. Antibiotic inactivation screen of the soil library. Cultures of liquid SIM supplemented with
antibiotic (20 mg/ml) were grown from spore suspensions. Supernatants were used as samples in
disk diffusion assays, and putative inactivating strains were identified by the absence of a zone of
Number of strains Complete inactivation: %
Resistant Screened for inactivationOf isolates screened Of library
*Not applicable. Statistic cannot be determined, because all resistant isolates were not assayed.
Fig. 3. Modification of
telithromycin by strain
Ja#7. (A) Culture media
mycin were analyzed by
high-performance liquid
chromatography with in-
line electrospray mass
spectrometry analysis.The
modification of telithro-
mycin was accompanied
an increase in mass-to-
charge (m/z) ratio, and
the loss of antimicrobial
activity against the indi-
cator organism Micrococ-
cus luteus. (B) Structures of telithromycin and the Ja#7 inactivation product.
20 JANUARY 2006VOL 311SCIENCEwww.sciencemag.org
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previous studies that found natural sequence
variation within this domain in soil bacteria
(19). Knowledge of such natural variations
could complement studies on clinical isolates
to guide the rational development of next-
generation fluoroquinolones that will be active
against resistant strains.
Resistance to macrolide antibiotics in patho-
gens of clinical significance has increased
considerably over recent decades and is com-
monly a result of antibiotic efflux and ribosomal
protection mechanisms (20, 21). Substantial lev-
els of macrolide resistance were also detected
in our soil isolate library, both to the natural
product erythromycin (introduced in 1952, 27%),
and the semisynthetic telithromycin (FDA-
approved in 2004, 17%). The high frequency
of telithromycin resistance was particularly in-
triguing, because telithromycin is known for its
activity against macrolide-resistant bacteria.
Five percent of library isolates detoxified
telithromycin in culture media (Table 1). One
of these, Streptomyces strain Ja#7 (MIC of
32 mg/ml), completely modified telithromycin to
an inactive hydrophilic product with a mass of
973.6 daltons (Fig. 3). This addition of 162 dal-
tons to telithromycin (811.7 daltons) is a signa-
ture indicator of monoglycosylation. Large-scale
purification of the product, followed by multi-
analysis, confirmed that the inactive product was
2¶-O-glucosyl-telithromycin (table S1).
Modification of the cladinose 2¶-OH of
erythromycin is known to result in antibiotic
resistance (22, 23). However, Ja#7, despite its
ability to inactivate telithromycin, was unable
to completely inactivate erythromycin or its
derivative clarithromycin under identical con-
ditions. Thus, a distinct mechanism seems to be
operating. Given the abundance of resistance
determinants in streptomycetes that are homol-
ogous to those in clinically significant pathogens
(5, 24, 25), it is evident that once this mechanism
is fully characterized, it should be monitored as
telithromycin use increases clinically and resist-
ant organisms inevitably emerge.
This study provides an analysis of the
antibiotic resistance potential of soil micro-
organisms. The frequency of high-level resist-
ance seen in the study to antibiotics that have
for decades served as gold-standard treatments,
as well as those only recently approved for
human use, is remarkable. No class of antibiotic
was spared with respect to bacterial target or
natural or synthetic origin. Although this study
does not provide evidence for the direct transfer
of resistance elements from the soil resistome
to pathogenic bacteria, it identifies a previously
underappreciated density and concentration of
environmental antibiotic resistance. The level
and diversity of resistance uncovered in this
work is only partially reflective of the true
extent of the environmental resistome, because
this study was restricted exclusively to cultur-
able spore-forming bacteria, which represent
only a fraction of soil-dwelling bacteria. For
example, a recent soil metagenome analysis
uncovered several aminoglycoside resistance
genes in uncultured organisms (26). Further-
more, the primary screen was conducted at high
antibiotic concentrations, thereby excluding
phenotypes exhibiting low to intermediate re-
sistance. The level of resistance genes in the
environment is therefore very likely to be sub-
stantially higher and the antibiotic resistome
much more extensive than this study reveals.
The survey of antibiotic resistance mecha-
nisms can assist the elucidation of novel mecha-
nisms that may emerge clinically, as well as
serve as a foundation for new antibiotic devel-
opment. In addition, the study of enzymatic
inactivation could lead to the development of
inhibitors for combination therapies to restore
antimicrobial activity.
References and Notes
1. T. Kieser, M. J. Bibb, M. J. Buttner, K. F. Chater, D. A.
Hopwood, Practical Streptomyces Genetics (John Innes
Foundation, Norwich, UK, ed. 1, 2000).
2. B. K. Hubbard, C. T. Walsh, Angew. Chem. Int. Ed. Engl.
42, 730 (2003).
3. E. Cundliffe et al., Antonie Leeuwenhoek 79, 229 (2001).
4. J. Davies, Science 264, 375 (1994).
5. C. G. Marshall, I. A. Lessard, I. Park, G. D. Wright,
Antimicrob. Agents Chemother. 42, 2215 (1998).
6. H. J. Hong, M. S. Paget, M. J. Buttner, Mol. Microbiol. 44,
1199 (2002).
7. L. Guardabassi, A. Dalsgaard, Appl. Environ. Microbiol.
70, 984 (2004).
8. C. T. Walsh, Antibiotics: Actions, Origins, Resistance
(American Society for Microbiology Press, Washington,
DC, ed. 1, 2003).
9. H. Myllykallio, D. Leduc, J. Filee, U. Liebl, Trends
Microbiol. 11, 220 (2003).
10. D. R. Snydman, N. V. Jacobus, L. A. McDermott, J. R.
Lonks, J. M. Boyce, Antimicrob. Agents Chemother. 44,
3447 (2000).
11. I. A. Critchley et al., Antimicrob. Agents Chemother. 47,
1689 (2003).
12. W. E. Alborn Jr., N. E. Allen, D. A. Preston, Antimicrob.
Agents Chemother. 35, 2282 (1991).
13. D. Jung, A. Rozek, M. Okon, R. E. Hancock, Chem. Biol.
11, 949 (2004).
14. M. Debono et al., J. Antibiot. (Tokyo) 41, 1093 (1988).
15. M. Gellert, K. Mizuuchi, M. H. O'Dea,T. Itoh, J. I.Tomizawa,
Proc. Natl. Acad. Sci. U.S.A. 74, 4772 (1977).
16. H. Peng, K. J. Marians, J. Biol. Chem. 268, 24481 (1993).
17. L. J. Piddock, Drugs 58 (suppl. 2), 11 (1999).
18. J. H. Tran, G. A. Jacoby, Proc. Natl. Acad. Sci. U.S.A. 99,
5638 (2002).
19. B. Waters, J. Davies, Antimicrob. Agents Chemother. 41,
2766 (1997).
20. G. V. Doern et al., Antimicrob. Agents Chemother. 45,
1721 (2001).
21. P. Descheemaeker et al., J. Antimicrob. Chemother. 45,
167 (2000).
22. N. Noguchi et al., Antimicrob. Agents Chemother. 39,
2359 (1995).
23. E. Cundliffe, Antimicrob. Agents Chemother. 36, 348 (1992).
24. C. J. Thompson, G. S. Gray, Proc. Natl. Acad. Sci. U.S.A.
80, 5190 (1983).
25. I. Chopra, M. Roberts, Microbiol. Mol. Biol. Rev. 65, 232
26. C. S. Riesenfeld, R. M. Goodman, J. Handelsman, Environ.
Microbiol. 6, 981 (2004).
27. We thank K. P. Koteva for helpful discussions and
analytical expertise; B. Ghadaki, C. Capone, and T. Patel
for help with construction of the soil library; and
S. Projan, P. Bradford, and J. Silverman for careful
reading of the manuscript. This work was funded by the
Canadian Institutes of Health Research and by a Canada
Research Chair to G.D.W. Accession numbers for
nucleotide sequences deposited in GenBank run
consecutively from DQ311010 to DQ311051.
Supporting Online Material
Materials and Methods
Figs. S1 to S4
Tables S1 to S5
30 September 2005; accepted 12 December 2005
Vaccinia Virus–Induced Cell Motility
Requires F11L-Mediated Inhibition
of RhoA Signaling
Ferran Valderrama, Joa ˜o V. Cordeiro, Sibylle Schleich, Friedrich Frischknecht,* Michael Way†
RhoA signaling plays a critical role in many cellular processes, including cell migration. Here we
show that the vaccinia F11L protein interacts directly with RhoA, inhibiting its signaling by blocking
the interaction with its downstream effectors Rho-associated kinase (ROCK) and mDia. RNA
interference–mediated depletion of F11L during infection resulted in an absence of vaccinia-
induced cell motility and inhibition of viral morphogenesis. Disruption of the RhoA binding site
in F11L, which resembles that of ROCK, led to an identical phenotype. Thus, inhibition of RhoA
signaling is required for both vaccinia morphogenesis and virus-induced cell motility.
lifetime of multicellular organisms (1, 2). De-
regulation of these two fundamental cellular
processes frequently occurs during pathological
he spatial and temporal regulation of
cell adhesion and motility is essential
during development and throughout the
situations such as tumor cell metastasis (3, 4).
Dramatic changes in cell migration and adhe-
sion, as well as loss of contact inhibition, are
also observed during many viral infections, in-
cluding that of vaccinia virus (5, 6). In contrast
to the wild-type Western-Reserve (WR) virus,
www.sciencemag.orgSCIENCEVOL 311 20 JANUARY 2006
on October 1, 2007
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text:
Editor/Publisher of a business and marketing newsletter focused on the maturing document capture and imaging industry.
PDF Technical Conference: October 19-20, San Jose, CA
Square 9's Encompass 2015: Oct. 20-23, Clearwater Beach, FL
AIIM Conference 2016: April 26-28, New Orleans, LA
Harvey Spencer Associates Capture 2016: Sept. 7-8, Glen Cove, NY
BURLINGTON, Mass.--(BUSINESS WIRE)--Nuance Communications, Inc. (NASDAQ: NUAN), today announced an extension to the strategic partnership with Samsung Electronics to provide Nuance document imaging solutions. Click on headline to read complete release.
{PrizmCloud-viewer viewertype="html5" document=" http://documentimagingreport.com/PDF/presreleases/Nuance-Samsung.pdf " viewerwidth="750" viewerheight="1000" toolbarColor="CCCCCC" printButton="Yes" }
For the last 20 years, Enterprise Content Management (ECM) software has made the job of storing, retrieving, indexing and sharing documents electronically easy — until the software goes out of date, is no longer supported, or the manufacturer is acquired, forcing a change on users. Click title to read complete case study.
{PrizmCloud-viewer viewertype="html5" document=" http://documentimagingreport.com/PDF/presreleases/IDTConversion.pdf " viewerwidth="750" viewerheight="1000" toolbarColor="CCCCCC" printButton="Yes" }
Ricoh survey details obstacles to 'information mobility'
Organizations rarely lack information in this new world of work. Unfortunately, information is gridlocked and unavailable to drive business decisions on the fly, according to new research from Ricoh and IDC.
{PrizmCloud-viewer viewertype="html5" document=" http://documentimagingreport.com/PDF/presreleases/RICOH Mobility.pdf " viewerwidth="750" viewerheight="1000" toolbarColor="CCCCCC" printButton="Yes" }
Upland Software, Inc., a leader in cloud-based Enterprise Work Management applications, today announced that the latest version of its FileBound document and workflow automation application is now available. This latest edition extends the robust web-based capabilities of FileBound to bring people, processes and information together in easy-to-use ways that support compliance and accountability.
{PrizmCloud-viewer viewertype="html5" document=" http://documentimagingreport.com/PDF/presreleases/FileBound 7 2.pdf " viewerwidth="750" viewerheight="1000" toolbarColor="CCCCCC" printButton="Yes" }


text:
The last thing you want to worry about when polishing that big $$ proposal is whether your recycled binders and presentation folders are going to arrive on time. We've been there and we feel your pain. That's why we are super excited to announce massive savings on the cost of expedited shipping. Our commitment: Expedited shipping rates have been slashed by up to 50%. That's right... we're splitting the cost of faster shipping. Expedited orders before 12 Noon Pacific Time will ship that day.* Just place the order and leave the rest to us. Full refund over $100. Don't know if you need ReBinder Original or ReBinder Select? Unsure about how many folders you'll require? No problem! Order everything you may... Continue Reading →
As some of you who follow me socially @GuidedStober and other, you may know that I have spent quite a bit of time at Seattle Children's Hospital with my youngest little girl Chase who is now 6. Long story short, Seattle Children's basically saved her life....and we now spend regular time there with frequent appointments. So we are forever in their debt. That's why when I had the chance this holiday season to play Guided Santa it was so incredible. While some might call it just the formal end of a different business we dipped our toe in at Guided, I liked to look at it as a pretty sweet opportunity to give something back....as an organization and for me personally since I... Continue Reading →
You know what they say, copying is the best form of flattery..... When we set out to design our next in the line of awesome Guided gear, we thought to combine (some might say hack) two of our favorites - anything American Original and being partial towards a little libation now and again. Naturally we landed on Jack Daniel's Tennessee Whiskey. I mean, come on - what's more American than a Bourbon. Without any further ado, we present the Jack Daniel's inspired Guided Holiday Hoodies (of course, available in Red and Blue): And of course an in action shot of me about to get to work one of our cylinder at Guided's factory. All right, just modeling and yes I will... Continue Reading →


text: AMRI's Marth to be Commencement Speaker April 1, 2015 William S. Marth, President and CEO of Albany Molecular Research Inc., will be the commencement speaker at the May 16 graduation ceremony for the College's Albany Campus. Prior to joining AMRI, Mr. Marth was a key strategist who helped establish Teva as a leading specialty pharmaceutical... View More Former Gov. Douglas to Address VT Grads April 1, 2015 Former Vermont Governor James Douglas will be the commencement speaker at the May 17 graduation ceremony for the College's Colchester, Vermont Campus. Gov. Douglas served in Vermont state government for more than 35 years, including four terms as governor from 2003 - 2011. View More Tarun B. Patel Named Provost of College March 27, 2015 Tarun B. Patel, Ph.D, has been named Provost and Vice President of Academic Affairs following a nationwide search. He will oversee all areas related to academic programming, research and scholarship, student affairs, and faculty development. Dr. Patel will assume his new role on July 1, 2015. View More Pages < 1 2 3 4 5 6 7 > Archive Year201520142013Media ContactGil ChorbajianDirector of CommunicationsWork: 518-694-7394Cell: firstname.lastname@example.com Publications ACPHS In The News


text:
I Do Not Have A Gentle Heart Poster
Game of Thrones
(approx. $6.01 or €5.45)
- In Stock
- Usually Ships in 1-2 Days
- UK & Worldwide Delivery
- Product Type: Poster
- Size: 61cm x 91.5cm
- Product Code: 53759
Follow in the footsteps of House Targaryen's last descendant on your quest to rule the seven nations from upon the Iron Throne. Featuring Daenerys Targaryen as she proclaims "I Do Not Have A Gentle Heart" stood against a wall in the gentle light of the moon, this poster is officially licensed and is perfect for any Game of Thrones fan!


text:
Category Archives: Feature Video
Last week, it was my honor to fly to Los Angeles to sit down for an interview with PBS' Tavis Smiley for his nationwide late night show, to discuss my new book Crude Justice: How I Fought Big Oil and Won, and What You Should Know About the New Environmental Attack on America. It was a fast-moving conversation that touched a lot of ground, including my early cases over radioactive [...]Read More »
This post is temporarily unavailable. © Smith Stag, LLC 2014 – All Rights ReservedRead More »
Over the last 12-plus months, I've written numerous blog posts about the situation in and around the small Louisiana town of Bayou Corne, where warning signs of earth tremors and methane odors gave way to a sinkhole that eventually grew to the size of the Louisiana Superdome and has kept on growing. One subplot in all my writing about the sinkhole — the result of a salt-dome mining operation by [...]Read More »
Six Hundred Days of Blasting: Miami's Beloved Biscayne Bay Faces Destruction from "Project Deep Dredge"
Biscayne Bay's pristine tropical waters teem with exotic marine life from manatees to dolphins to "super corals" to environmentally critical sea grasses. Strips of mangroves and wetlands cushion the shores. The bay's untamed beauty attracts millions of tourists annually and draws nature-lovers and sun-worshipers from around the world to live on its idyllic shores. The Biscayne Bay Aquatic Preserve provides a safe haven for endangered species and an ideal nursing ground [...]Read More »
Fighting Back One Song at a Time: Cajun Crawfisherman Drew Landry Sings the "BP Blues" to Help Restore Gulf Coast
Drew Landry, an out-of-work Cajun crawfisherman, caused a stir last year when he whipped out a guitar and, literally, started singing the blues during his testimony before the National Oil Spill Commission – the body established by the White House to investigate the causes and impacts of the BP spill. My guess is it was a first for all involved. But one thing's for sure: There's nothing like music to [...]Read More »
Gulf Researcher Says BP Spill Likely Cause of "Sick Fish" Epidemic: "I've Never Seen Anything Like This…Ever"
The fear is palpable on the docks from Galveston to Panama City. Commercial fishermen working the waters hardest hit by the BP oil spill are worried sick about their future. It keeps them up at night. Many are convinced the 200 million gallons of crude that spewed into the Gulf last year have done irreparable damage to the fragile fisheries that provide their livelihood. According to a new CBS News [...]Read More »
Video from the Vault: Veteran Toxicologist Warns of Increased Risk of Cancer and Birth Defects Tied to Later Stages of Spill; Unprotected Cleanup Workers at Highest Risk
Here's a musical take on the dangers of Fracking:
Read More »
WPI Chemical Engineer Marco Kaltofen speaks about the dangers of dispersants and explains his own experiment that found that dispersant use makes oil 35x more available in the water column. Stay tuned for more from Mr. Kaltofen
Read More »
This video, shot earlier this year, gives a glimpse of just how far we have to go before cleanup efforts are complete. And with each passing day, the chances fade that BP will ever fully restore our marshes, waters or shoreline as debris and waste blend further into the landscape. Watch the video and you'll see what I mean.
Production Note: We had to block the faces of individuals in the video to protect their identities.Read More »


text:
What Would You Do With $70,0000, Capital Region? Buy A Maserati?
Some people are doing it! According to the TimesUnion.com, Maseratis are starting to sell in the Capital Region. So are other high ticket items. Go figure...
Some people are doing it! According to the TimesUnion.com, Maseratis are starting to sell in the Capital Region. So are other high ticket items. Go figure...
Bingo. It's New York! Congratuations. We win again!
Ace Hardware has to be a real bunch of happy campers, and so do the folks who work there. Looks like there's going to be an expansion!
There are certain decisions from "above" that you have to accept. There are others that you can understand for financial reasons, but totally ticks you off. This is one of them.
I'm a man on a mission. The property taxes we're paying are absurd for what we're getting. I'm ready to load up the moving van, but want to know where to go?
If you tell me yours, I'll tell you mine (but it might just give away my age!)
I think that we're all very happy about how gas prices have been dropping.
We might as well start a club and have a party (if we can make the payments). America is sucking wind when it comes to finances.
I've never heard of this before, have you? A company that lets you basically "borrow" a car for a short period? (Borrow might be the wrong word - you DO have to pay for it). But it's coming to the area by the end of June. It's called Capital CarShare
Are you looking for a summer job? Check out the job fair happening in Troy this week!
There are all kinds of statistics showing that New York's population is dwindling. People are getting fed up with taxes and the cost of living. Maybe we should move to Seattle
I think I've heard every possible option that you could think of for where to put the first big gambling casino in our area. Where do YOU think it would work best (or do you hate the idea completely?)


text:
"A writer is a writer not because she writes well and easily, because she has amazing talent, because everything she does is golden. In my view a writer is a writer because even when there is no hope, even when nothing you do shows any sign of promise, you keep writing anyway."
– Junot Diaz, from his essay "The List"
There was a time, not so long ago, when I was ready to quit writing. My dream since childhood. The one true thing I knew about myself – or so I thought.
I was a thirty-eight year old stay at home mom living in Brooklyn, New York. My daughter was in kindergarten and I spent my days caring for my toddler son. All seemed well except we were barely scraping by on my husband's erratic real estate salary. I couldn't help feeling guilty, wishing I could do more to help.
The truth is I was doing plenty by being the primary caregiver to our kids, but the world places an emphasis on financial viability, as does city living, and I began to wonder if I had made a terrible mistake chasing my writing dream instead of building a practical career.
As my family struggled with big questions about the future, I felt a question of my own take root inside my heart like a stubborn weed.
What if being a writer was not my destiny, but just a story I'd been telling myself? « Continue »


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LSI Corporation (LSI)
Q4 2008 Earnings Call
January 28, 2009 5:00 pm ET
Sujal Shah - VP, IR
Abhi Talwalkar - President and CEO
Bryon Look - EVP and CFO
Kaushik Roy - Pacific Growth Equities
James Schneider - Goldman Sachs
Craig Berger - FBR Capital Markets
Shawn Webster - JPMorgan
Eric Ghernati - Banc of America-Merrill Lynch
Welcome to the LSI Corporation investor relations conference call.
(Operator Instructions).
I would now like to turn the conference over to your host, Sujal Shah, Vice President of Investor Relations at LSI. Mr. Shah. Please go ahead sir.
Sujal Shah
Previous Statements by LSI
» LSI Corporation Q3 2009 Earnings Call Transcript
» LSI Corporation Q2 2009 Earnings Call Transcript
» LSI Corporation Q1 2009 Earnings Call Transcript
During this call, we'll be mentioning non-GAAP financial measures, which we may refer to as results excluding special items. Today's earnings release describes the differences between our non-GAAP and GAAP reporting. You can find reconsolidations of our non-GAAP financial measures to corresponding GAAP amounts on our website at www.lsi.com/webcast. At that site, you can also find a copy of the earnings release and a presentation, which highlights the key points from today's call, and provides an overview of our business. This may be particularly useful to new investors.
I also want to remind you that today's remarks will include forward-looking statements. Our actual results could differ materially from those suggested by the statements made today. Information about factors that could affect our future results is contained in our quarterly report on Form 10-Q for the quarter ended September 28, 2008 and our Annual Report on Form 10-K for the year ended December 31, 2007.
With that, it is now my pleasure to introduce Abhi Talwalkar.
Abhi Talwalkar
Thank you, Sujal. Good afternoon and welcome. I would like to start by recapping some of our accomplishments in 2008, and then address how we intend to emerge as a stronger company coming out of this economic downturn.
For 2008, LSI delivered many solid achievements, despite tough second half economic conditions; we demonstrated year-over-year revenue growth in storage systems, storage semis, our go-forward networking products and IP licensing. Our quarterly operating expense run-rate was significantly reduced. We grew non-GAAP earnings $0.44 per share representing nearly 70% growth over 2007.
We significantly increased our operating margins over 2007. We expanded non-GAAP gross margins by 320 basis points. We completed our shift to a 100% outsourced manufacturing model across all our product families. And lastly, we reduced our outstanding share count.
To compliment our financial performance, we also generated significant design win momentum at key customers in both storage and networking. Had it not been for the economic downturn, I am confident that LSI was on its way to achieving its target business model in the December quarter.
The progress we have made in such a short time reinforces that we have the right strategy and execution to drive long-term improvements in revenue, earnings and ultimately shareholder value. As we operate in this environment, our game plan is to play offense and emerge stronger through this downturn. We have just come off of two years of unprecedented design win activity and successful execution of those key programs will allow us to gain share and grow at above market rates as end market demand improves.
As we navigate through this environment, we have three main objectives; first, to extend our competitive lead in key product areas; second, to further elevate our design win momentum; and third, to carefully manage our solid cash position. Successful execution to these objectives should lead to significant increase in long-term shareholder value, which is the focus of this Management team.
Before I give you my perspective on extending our competitive lead and elevating our design win momentum, I would like to outline the changes we have made that have put us on solid financial ground. From prior to the merger through Q3 2008, we reduced our non-GAAP operating expense levels by approximately $60 million per quarter. We divested the lower margin and more volatile consumer and mobility businesses at the right time.
We changed our manufacturing strategy to an outsourced model making our costs mostly variable and lowering capital expenditure requirements. We are now taking the following additional steps to further reduce operating expenses and effectively manage our cash, including a 5% reduction of our global workforce. The suspension of company matching 401(k) contributions and freezing of our pension plan, the suspension of salary increases for all employees, reduction of all discretionary spending and a corporate level restructuring designed to increase synergies across our semiconductor investments, reduced overhead costs and eliminate corporate functions.
We expect the net impact of these and other cost cutting actions to be a $20 million reduction in non-GAAP operating expenses per quarter compared to our previous run-rate of approximately $245 million per quarter with no impact to the key programs that we expect to drive future growth.
Now let me talk about how we intend to emerge a stronger company through this downturn and drive long-term improvements to shareholder value. The key to extending our competitive position is delivering leading edge in differentiated technology and products that generate breakaway opportunities against the competition.
There are several key development programs in 2009, which we believe will enable us to distance ourselves further from the competition yielding share gains and future growth. Our next-generation 40-nanometer read-channel technology will deliver best-in-class signal-to-noise ratio and allow us to leapfrog the competition. In systems, our next-generation external entry platform will incorporate LSI's leading-edge storage processor and deliver twice the performance and scalability at a far less cost.
Read the rest of this transcript for free on seekingalpha.com


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Hey everybody!
Here are my feature dancing dates. If you live close by make sure to stop in and say hello.
May 19-20
Spearmint Rhino: Oxnard
630 Maulhardt Ave.,
Oxnard, CA
June 23-25
602 Broad Hollow Rd.,
Melville, NY
July 7-9
Spearmint Rhino: City of Industry
15411 East Valley Blvd.,
City of Industry, CA
July 28-30
Larry Flynt's Hustler Club
5420 Bunkum Rd.,
Washington Park, IL
August 11-13
AL'S Diamond Cabaret
1810 North 5th St.,
Reading, PA
August 18-20
Solid Platinum
1101 New Circle Rd. East,
Lexington, KY
For more info visit NikkiBenz.com
Hugs & kisses,
Daddy's Girls 2 ~ Reviewer Rated
Calvert Joins Gamelink
Interrogated ~ Reviewer Rated
1st AFFLV Hits Cashman
Richelle Ryan Naked Yoga
Morgan, Lindemulder Headline Exxxotica
A French Documentary Like No Other
Night at the Erotic Museum
Hill and Howard Raw
Taboo is Delicious
Night, Rai, Moore, on Inside
Candida Royalle Passes
Cindy Starfall Appearances
Priya in NYC
More w/Mo Celebrates 100
Angel, Albrite AVN Awards Hosts
The Upward Trending Trannie
Elizabeth Bentley Hits Circuit
Tony Batman to Big Easy
Cleopatra Dead
Introducing Bitcoin Porn Sites
Candidate Sex Tape Scandal
Donald Trump Porn Parody
Savana Styles Available
Sex with Donald Trump
Ashley Sinclair Sex Tape
Mercedes Carrera NightMoves Nom
Allie Haze in Columbus
Vivid NYC Nommed
Raven Bay at Exxxotica
Little Sassee Cassee in OK
Dee, Michaels in Alabama
Nikki Benz Headlines Ohio
Galaxy Stars to Exxxotica
Caribbean Playground Party
Throwback Expo Registration Rates!
Tanya Tate at Comic Con
Bridget the Midget at Vivid Houston
Ideal Image Supperclub Party
Angela Sommers in Houston
Starfall to Exxxotica
Prinzzess at Treasure Chest
Danica Dillon in Bath
Library Girl at Exxxotica
ED Awards Host Thea Vidale
National Porn Star Day
Strippers Ready for Baseball
Karaoke XXX Needs New Location
ED Expo to Big Easy
Layla Price at Foxxx Booth
Nikki Phoenix Party
Viva Las Vicki
Kendra Lust in Detroit
Starr Sisters in Houston
Nikki Phoenix Update
Vegas Heat Party
XBIZ Rooftop Party
Heaven & Hell Halloween Party
Farrah Abraham at Hustler Hollywood
Amber Lynn at Wasteland
Stripclub Microbrewery on CNN
Nikki Phoenix Karaoke XXX
Asianmodelpalooza 14
Nikki Phoenix Appearances
Miss LA Karaoke XXX
Nikki Delano at Centerfolds
Evil Pin-Ups Karaoke XXX
Monique Alexander in Houston
Nikki Phoenix Hosts Palomino
Clubs & Appearances Section Index


text:
MDA continues surveillance service for Australian Defence Force
MacDonald, Dettwiler and Associates Ltd. ("MDA" or the "Company") (TSX: MDA), a global communications and information company, announced today that it has been contracted by the Commonwealth of Australia to continue MDA's Unmanned Aerial Vehicle surveillance service for the Australian Defence Force in Kandahar Airfield, Afghanistan until the middle of 2014.
MDA has been supporting the Australian Forces by providing critically important real-time intelligence, surveillance and reconnaissance information directly to ground commanders since January 2010 .
The Military Communications Market: 2015 - 2030 - Opportunities, Challenges, Strategies & Forecasts
Your company's press release on ASDNews and to thousands of other journalists and editors? Use our ASDWire press release distribution service.
Source : MacDonald, Dettwiler and Associates Ltd.
Maritime Surveillance and Reconnaissance Technology 2016 Conference
Feb 15 - 16, 2016 - Rome, Italy
US Export Controls with REFORM CHANGES Seminar
Dec 7 - 10, 2015 - Miami, United States
Civil & Commercial Unmanned Aerial Systems Symposium
Oct 27 - 28, 2015 - Washington, United States


text:
Due to the overwhelming success of Judas Priest's 17th studio effort overall, 'Redeemer of Souls' (which became the highest-charting album of their career, when it debuted on the Billboard 200 charts at #6), the band has announced a fall tour, which will hit the U.S. and Canada, from October 16th through November 12th. Supporting Priest on the U.S. dates and the Halifax engagement will be one of modern metal's top bands, Mastodon. 'Redeemer of Souls' also went on to become one of the most critically acclaimed releases of the band's career, with Rolling Stone stating, "Above all, 'Redeemer' is proof that Priest can still call themselves metal's defenders of the faith," while Revolver Magazine offered further praise, "Thus rejuvenated and recharged, the Metal Gods have delivered their strongest record in over a decade." Comprised of Rob Halford (vocals), Glenn Tipton (guitar), Richie Faulkner (guitar), Ian Hill (bass), and Scott Travis (drums), Judas Priest is responsible for some of heavy metal's all-time classic anthems ("Living After Midnight," "Breaking the Law," "You've Got Another Thing Coming," etc.) and albums ('British Steel,' 'Screaming for Vengeance,' 'Painkiller,' etc.). Ever since the release of 'Redeemer of Souls,' Judas Priest has been taking their music all over the world. And they are not finished yet, with the announcement of these new dates! JUDAS PRIEST TOUR DATES: October 16th, 2015 Paso Robles, CA Vina Robles Amp October 17th, 2015 Las Vegas, NV The Pearl October 20th, 2015 San Francisco, CA The Warfield Theatre October 21st, 2015 San Jose, CA City National Civic October 23rd, 2015 Fresno, CA William Saroyan Theater October 24th, 2015 San Bernardino, CA Knotfest October 27th, 2015 Vancouver, BC Hard Rock Casino October 28th, 2015 Vancouver, BC Hard Rock Casino October 31st, 2015 Regina, SK Brandt Center November 1st, 2015 Winnipeg, MN MTS Center November 3rd, 2015 Peoria, IL Civic Center November 6th, 2015 Huntington, NY Paramount Theater November 7th, 2015 Newark, NJ Prudential Center November 10th, 2015 Halifax, NS Scotiabank Center November 12th, 2015 Toronto, ON Air Canada Center
FOR FURTHER INFORMATION VISIT: www.judaspriest.com www.facebook.com/
Admirers of such prog rock heavyweights as of Pink Floyd, earlier Genesis, Yes, Renaissance, and Jethro Tull are sure to enjoy the latest release from Giannotti, entitled 'The Great Unknown.' The Connecticut-based singer/guitar/flute (multi instrumentalist) has previously appeared on the Jasper Wrath Album, three of Cannata/Cannata-Arc Angel CD's and the 1997 Jasper Wrath 'Anthology' release, before recently issuing his aforementioned solo debut. And Giannotti worked with the best in the business on 'The Great Unknown,' by enlisting Jonathan Wyner (who has previously worked with James Taylor, David Bowie, Aerosmith, Kiri Te Kanawa, etc.) to master the album, and having artist Ioannis (who has worked with Fates Warning, Dream Theater, AC/DC, Deep Purple, King Crimson etc.) to supply the artwork for the album cover. Speaking to the Classic Rock Revisited site, Giannotti was asked the meaning behind the album's mysterious title. "Well Jeb, the answer to that question is........ Unknown. Sorry, couldn't resist. No secret meaning, it sounded mysterious and I like a little mystery. The Unknown is really about the future, for better or worse. In the title track it's making it for the better. For the most part I like my lyrics to be positive and uplifting. Too much negativity out there." In the same interview, Giannotti was also asked if 'The Great Unknown' was written as a concept album. "It was never intended to be a concept album, although 'Sacred Ground' fits perfectly coming off 'The Great Unknown.' That said, because the theme of all seven pieces were written from the same perspective, they do seem to fit. The track order had to be in that sequence to make it work." Additionally, the reviews regarding 'The Great Unknown' have been stellar, as evidenced by a write-up in Progression Magazine by John Collinge, which stated "Giannotti is an excellent singer, player, and composer of melodies that register addictively from the first listen. He also writes enchantingly cogent lyrics, whose themes of inner/outer travels through time and distance impart a wistfully poignant sense of wonder." Additionally, Classic Rock Revisited gave it an "A" rating, and offered further praise - "This one is a winner from start to finish. Buy this one and support real music being made by real artists." And writer Jeb Wright has been a supporter of Giannotti and his music, stating that "What was created is a complex and multi-demensional album that is honest and pure in it's intention. This is a classy, thought and feeling provoking album from the opening note until the finale" and "'The Great Unknown' is a progressive, art rock masterpiece."


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You could go for an old trick where the alien races have limited resources, and Earth is a figurative gold mine. It could begin from attempting to fight off the first invasion, which nearly wipes out the entire human race. Then The Empire is formed with the remaining population, and you reverse engineer the aliens and what they had to gain a basic advancement, sort of leveling the playing field without making you strong yet.
Additionally, in relation to focusing on one Empire, you could say that due to their limited resources much dissension within the alien races was created, and so their is no significant power left. The problem you arise with there being only one Empire, is that there is no plausible reason (that I can think of) for any significant advancement in power/numbers over time.
On the note of the 'Eliminators', I think it could work quite well. Perhaps the reason Earth was attacked now is because a prophecy, or event, has taken place that revealed to them their limited time before the 'invasion'. Over time, through defending the Empire you created and collecting information on your enemies, you discover this. By that time, you have become a lot more powerful, and so you will shift away from the minuscule fights with the aliens and face the much larger threat at hand. This could easily explain a change in difficulty as well.


text:
Smith & Wesson
When merchandise moves from product to icon, American consumerism legends are born. That's the case with Smith and Wesson. You recognize the name because of the iconic status of their products. But we're betting you didn't realize that the same folks who made the smooth piece of heat you saw in that movie last week also make a smokin' pair of boots. As powerful and unique as their guns, Smith and Wesson boots deliver pure quality and loads of support for a variety of applications. Our Smith and Wesson Boots offer features like Waterproof uppers and cushioned interiors. If you're working in a high-security environment and don't want to hassle with metal detectors, you'll love our Smith and Wesson Non-Metallic Boots. Black and smooth like their legendary pieces, Smith and Wesson boots keep your feet professional and smooth in sleek, polished uppers. Pick out your pair of Smith and Wesson Work Boots and create a legendary walk to conquer the work floor.
There are no products matching the selection.
I do want to thank your company for such fast turn around on replacing my current boots. Sent them on a Monday after receiving your return label, had my new boots back on Friday, phenomenal! In today's business environment, I am pleased that such customer service still exist. I am telling all my friends about you and plan on giving you future business. Thanks again and Great job."
Mike M. from Russellville, Kentucky


text:
proportional spacing
)Using different widths for different characters. In a proportionally spaced font, the letter I is narrower than the letter q and the letter m wider. This book uses a proportionally spaced font, as do most books, magazines, and newspapers.
The opposite of proportional spacing is monospacing. In a monospaced font, each character has the same width. Non-graphics display screens, display text in a monospaced font. Almost all printers, with the exception of line printers, are able to print with either proportionally spaced or monospaced fonts.
Stay up to date on the latest developments in Internet terminology with a free weekly newsletter from Webopedia. Join to subscribe now.
From wacky alarm clocks to lecture hall tools and after class entertainment, these Android apps are a good fit for a student's life and budget. Read More »Sharing Threat Intelligence
A growing number of startups make the sharing of threat intelligence a key part of their solutions. Read More »Smiley Faces and Symbols
A text smiley face is used to convey a facial expression or emotion in texting and online chat conversations. This Webopedia guide shows you how... Read More »
The Open System Interconnection (OSI) model defines a networking framework to implement protocols in seven layers. Use this handy guide to compare... Read More »Network Fundamentals Study Guide
Networking fundamentals teaches the building blocks of modern network design. Learn different types of networks, concepts, architecture and... Read More »Computer Architecture Study Guide
This Webopedia study guide describes the different parts of a computer system and their relations. Read More »


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Malaysian Flight Search: Satellite Shows 122 Objects in Ocean
Malaysian officials call the latest satellite images the most credible lead yet.
Russian Satellite Plunging to Earth
Decommissioned Russian satellite Kosmos 1220 is making a high-speed re-entry into the atmosphere.
French Satellite Images Show Possible Objects
New satellite images from French show possible debris in the southern Indian Ocean.
Satellite Image Captures Fires Raging Across North Korea
NASA's Aqua satellite reveals plumes of smoke drifting across hundreds of miles.
Objects in Indian Ocean Are 'Best Lead' in Plane Search
The search for a missing Malaysia Airlines plane picks up off Australia's coast.
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text:
Select Local Merchants
Lifehouse of S.DRead MoreFor quality medical care, look no further than Lifehouse of S.D in San Diego. Feel and look your best with an alternative service from this clinic, such as physiotherapy. Lifehouse of S.D understands that getting sick can be a downer, and that's why the doctors offer kind and effective care to help you get back to feeling 100%.2828 Meadow Lark DrSan Diego, CA US
Sharp Mesa Vista HospitalRead MoreWhen you're not feeling well, the staff at Sharp Mesa Vista Hospital in San Diego can help you choose the best medical treatment for your symptoms. For medical treatments such as physicals and medical checkups, this medical facility is exactly what you need. Don't let that cold run you down - head on over to Sharp Mesa Vista Hospital and see a medical specialist.7850 Vista Hill AvenueSan Diego, CA US
Rady Children's Specialists of San DiegoRead MoreAttend to all of your medical services in one place at Rady Children's Specialists of San Diego in San Diego and start your road to better health. Providing high levels of medical expertise, the staff at Rady Children's Specialists of San Diego is readily available to assist you with your healthcare needs. The staff at Rady Children's Specialists of San Diego is here for you on days where you're not feeling well.8110 Birmingham WaySan Diego, CA US
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Body TapestryRead MoreIf you're on the market for a new furniture set, you can browse living room furniture and more here. When backyard festivities are on the brain, patio furniture is your next stop. Browse the selection available to find the set that's right for you. Deck out your bathroom with brand new furniture and transform your home in a pinch. Next time you're looking for the latest in office furniture, you can trust that store has the right selections to hook you up. If your bedroom is looking a little scarce, pick up some new furniture pieces such as bedroom furniture and make your bedroom feel even more comfortable. Treat yourself to artwork at its finest when you purchase a painting, drawing, or sculpture from here. If your walls are looking a little bare, spruce them up with items like curtains and mirrors. Items like rugs, throw pillows, and vases will provide your home with that much-needed flair, so get to decorating. If you are visiting Body Tapestry, you can take advantage of the nearby parking options during your stay.7910 Frost StSan Diego, CA US
TK Music StudioRead MoreEstablished: 2000 Reservations/Appointments: Required Staff Size: 5 person Average Duration of Services: 30–60 minutes Brands Used: Yamaha3290 Ashford St.San Diego, CA US


text:
The City Theatre for Performing Arts in Amsterdam is centrally located in the city. It's close to numerous restaurants, bars, pedal boats, the casino and much more. We watched a ballet performance of Scapino from Rotterdam. It was called 'Le Chat Noir' (the black cat) and it was fun. The theatre building is beautiful, especially the inside. There is also a part for drinks and a restaurant to eat something before or after performances. We would definately go here again.
If you own or manage De Stadsschouwburg, register now for free tools to enhance your listing, attract new reviews, and respond to reviewers.


text:
Raceland Upper Elementary to hold annual run
Published: Thursday, February 11, 2010 at 4:50 p.m.
Last Modified: Thursday, February 11, 2010 at 4:50 p.m.
THIBODAUX – Local runners and walkers can help a Raceland school get in better shape through an annual fundraiser next month.
The 10th Annual Raceland Upper Elementary School 5K Fun Run for Education is set for 9 a.m. March 20 on the school grounds, 3759 La. 308.
Race-day registration begins at 8 a.m.
Registration fees are $15 before Feb. 24 and $18 on that date and afterward.
Fees include a race T-shirt, refreshments, prizes to top finishers, giveaways, health screenings and fingerprinting.
Those registering after Feb. 24 can pick up their T-shirts at Raceland Upper two weeks after the race.
Registration fees are $10 without race T-shirts.
The event also includes a half-and-half raffle.
Proceeds go to instructional and supplemental materials for students at Raceland Upper.
Registration forms are available at the school and at area businesses.
For information, call 537-5142 and ask for Annette or Robin.
Reader comments posted to this article may be published in our print edition. All rights reserved. This copyrighted material may not be re-published without permission. Links are encouraged.


text:
Children Held At Gunpoint
Expand Messages
- Children Held at Gunpoint (07/18/08)
Asheville police are searching for suspects after a home invasion and
robbery in South Asheville.
Three children, ages 11-13, were alone in the home at the time. They
told police that three males entered the house through a basement
door, held them at gunpoint, taped their hands and mouths, and then
took several items, including money, jewelry, computer equipment and
passport documents.
Do you want this to be you or your family? I didn't think so....
This doesn't just happen to home it happens to businesses as well. I
bet that family didn't have a loss prevention plan in place. Are you
scared for you children when you are away? We can help you. VIP
protection but not VIP pricing.
WNC Security Specialists can help you!
We are available 24/7 365
CALL TODAY for a FREE price Quote 828-551-9658
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Zombie Loyalists – Book Review
Marketing and PR expert Peter Shankman has been working with the biggest companies in the world to create what he calls "Zombie Loyalists," fervent fans that help companies massively increase their customer base, brand awareness, and most importantly, revenue. After all, why should you have to tell the world how amazing you are if you can have your existing customers do it for you? Imagine an army of customers who will do your public relations, marketing and advertising, without being asked, each and every time they give you their money. These are Zombie Loyalists. They are ready to buy what you sell, respond to your email offers and demand that their friends to do the same.
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14 Toilet Paper Roll Craft Ideas
Bonus: Get our newsletter & special offers for free. We will not share or sell your email address. View our Privacy Policy
Paper Covered Picture Frame
By: Janet Wilhelm for Walnut Hollow
We are adding the craft to your Craft Projects.
The project was added to your Craft Projects.
Click here to view your Craft Projects.
Two coordinating sheets of decorative paper help frame a letter in this pretty wood frame. Make one for every member of the family or give as a gift.
- Walnut Hollow® #27753 Wood Frame – Small
- Walnut Hollow® #9912 Oil Colored Pencils
- Alphabet Stencil
- Paint (color of choice)
- 2 Sheets of coordinating Decorative Paper, 1 sheet of plain Construction
- Paper
- Other Supplies: brush, craft glue or paper glue, paper towel, pencil, Phillips screwdriver, ruler, sandpaper, scissors or X-acto knife, spray varnish
- To prepare wood for painting, use Phillips screwdriver to remove screws holding tabs on back of frame. Remove tabs, backing, and glass. Use sandpaper to lightly sand wood surface. Remove dust with paper towel.
- Use brush to apply a coat of paint to entire wood surface. Let dry. Apply second coat. Let dry.
- Apply 2-3 coats of spray varnish to frame. Let dry.
- Use ruler to measure decorative paper the same size as the front of frame. Use scissors to cut paper to size. Use glue to adhere paper to frame. (Another option) Apply glue to frame front. Place a piece of paper that is larger than frame on glue. Press in place. Place frame, paper side down, on cutting mat. Use X-acto knife to cut along outer edges and frame opening. Let dry.
- Use scissors or X-acto knife and ruler to cut construction paper to size of glass. Cut coordinating decorative paper slightly smaller than the frame opening so a quarter inch of construction paper shows around frame opening.
- Choose stencil alphabet letter to trace. Place stencil on the smaller decorative paper. Use pencil to trace letter. Use colored pencils to color in letter. Use glue to adhere initialed paper to construction paper.
- Replace glass in frame. Insert initialed paper. Replace backing. Use Phillips screwdriver to replace screws.
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text:
FriendBot Adder for Mobile
Quick Specs
Total Downloads:2,264
Date Added:Apr. 07, 2006
Price:Free to try (5-minute demo mode); $19.95 to buy
File Size:Not available
Downloads Last Week:6
From friendbot: FriendBot Adder sends real friend requests to the people whom you choose. It has 100% captcha bypass and the easiest interface ever. Includes global gender filter, age filter, and new band filter, as always there are free updates for life. With the built-in browser you can import users from comments, friends. The built-in browser lets you navigate wherever you want and import the friends on that page. This allows full range of MySpace search functions.
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Tommy McCoy started playing guitar at the early age of 8, in 1963. Quickly learning from 3 formal lessons and then picking it up from there. "I had an electric guitar in the 4th grade and started my own band in 5th grade". My earliest influences were Chuck Berry, Bo Diddley, the 3 Kings, Mike Bloomfield and every decent blues guitarist around back then. Having played professionally over much of N.E. Ohio from 1967-1976 between Cleveland and Youngstown, Tommy moved to Florida, opened up a used record store and started a Blues band. The Backdoor Blues band turned into the Screamin' Bluejays (w/ British bassist Barry Dean, from Oblivion Express and Denny Best, drummer for Big Twist). In 1980, Tommy met Stevie Ray Vaughan. The two became friends and spent numerous times together down in Florida. For one year,1986, Tommy went to San Francisco and recorded his first album (with Mark Hummel). He returned home and toured the S.E. with Johnny Thunder (Suzy Q, Loopty Loop). In 1990 Tommy hooked up with John Street in St. Petersburg and joined The Telephone Kings (including 3 former members of the Gregg Allman Band). They recorded a CD "More than you'll ever know", with mostly Tommy's originals. Two years later Tommy was working on his first solo CD project and went to Austin, Texas and recorded 6 songs with Chris Layton and Tommy Shannon (Double Trouble). He had become friends with them during his friendship with Stevie Ray. This CD was released as "Love N' Money". In 2002 Tommy recorded in legendary Kingsnake studios (Bob Greenlee) with Lucky Peterson on B3 organ. Produced by Rock Bottom, "Lay My Demons Down" was an internationally acclaimed CD and received worldwide airplay. This led to Tommy's 2 tours of the UK. His first festival over there (Blue Dragon), he was voted #1 artist, by peoples choice. "Live in the UK" resulted from these tours. Tommy's next project was a collaboration with his brothers. "I met 2 people in 2 weeks, who both knew Levon Helm and Garth Hudson. We all got together in Levon's barn studio in Woodstock, New York and recorded an array of Americana, Blues, Roots rock and 'Band' style originals I wrote". 'Angels Serenade' is the title of this CD and remains one of the top sellers in Tommy's catalog. Tommy has toured Norway with Rock Bottom and toured Finland with brother, Atlanta Bluesman Mark McCoy, on bass. Tommy released his 6th CD "Kickin' the Blues" with special guest Commander Cody.
Tommy's latest release is on major Blues label "Earwig Music Co.". Late in the Lonely Night is available digitally and online. A comprehensive Compilation CD is being produced. Look for tour dates later this year.


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Originally posted on Fox Sports Southwest | Last updated 4/12/13
Addition by subtraction or just a case of good riddance? Whatever the case, the San Antonio Spurs waived Stephen Jackson on the eve of the NBA playoffs Friday afternoon. The news sent shock waves from San Antonio across the league, as many wondered why a squad with title aspirations would let go of what appears to be a valuable piece now. Jackson, aka Captain Jack, won a title with the Spurs in 2003 and returned last season to great fanfare. Jackson has had his share of issues this season, some personal and others within the confines of the team. Reports of Jackson being upset with his role and playing time surfaced Friday, leading to run-ins with San Antonio coach Gregg Popovich. "Were getting ready for playoffs," Popovich said before Friday's game against Sacramento. "Putting our team together and what we want to do and who we want to do it with, we thought that making the decision with Jack was best for the group." Jackson can be claimed by another team, but he's ineligible ...
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