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This Excel tutorial explains how to use the Excel MEDIAN function with syntax and examples.
The Microsoft Excel MEDIAN function returns the median of the numbers provided.
The syntax for the MEDIAN function in Microsoft Excel is:
MEDIAN( number1, [number2, ... number_n] )
The MEDIAN function can be used in the following versions of Microsoft Excel:
The MEDIAN function can be used in Microsoft Excel as the following type of function:
Let's look at some Excel MEDIAN function examples and explore how to use the MEDIAN function as a worksheet function in Microsoft Excel:
Based on the Excel spreadsheet above, the following MEDIAN examples would return:
=MEDIAN(A2, A3) Result: 8.85 =MEDIAN(A3, A5, 45) Result: 7.2 =MEDIAN(A2:A6) Result: 8.1 =MEDIAN(1, 3, 13, 14, 15) Result: 13
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Proud sponsor of the Wenatchee Valley Woman of the Year Luncheon!
Visit the link above for more details on this year's event, and to register today.
Have someone to nominate for Woman of the Year? Fill out the Nomination form below and submit it to us by 21 Sept 2015.
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For the first time, the Bottger Mansion of Old Town Bed & Breakfast is offering a "Christmas in Old Town" package to our overnight guests including Christmas dinner, since the restaurants in Old Town are closed on Christmas Day.
Christmas in Old Town is magical, with thousands of luminarias lining the sidewalks and rooftops on Christmas Eve. You can arrive a little earlier that day and help us set up and light our own luminarias. We'll have Mexican hot chocolate in to-go cups for you to sip as you stroll through Old Town in the evening. Enjoy a fabulous breakfast in the morning accompanied by locally-roasted coffee or tea and a Christmas cracker at your place setting--wear the crown and look for your prize inside!
Christmas dinner starts with cranberry-apple salad with glazed pecans, followed by roast pork tenderloin with orange-chipotle sauce, couscous with pine nuts, and roasted asparagus with shaved Parmesan cheese. The dessert is New Orleans bread pudding with bourbon sauce and spiced whipped cream.
Treat yourself to an unforgettable Christmas in Old Town. Call or book online to make your reservation.
I'm having fun. Come on along!
Bottger Mansion of Old Town Bed & Breakfast
Old Town Albuquerque


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Amoderm Cosmetic & Wellness Medical CenterRead MoreAmoderm Cosmetic and Wellness Medical Center president and medical director Dr. Elham Jafari has a background in neurology, which gives her a keen insight into the workings of nerves and muscles beneath the skin. She and her medical staff apply this expertise to perform brief Botox or Juvéderm injections and accurately target veins during sclerotherapy sessions. IPL photofacials pulse beams of light into the skin, stimulating the production of collagen to produce youthful elasticity without strict spandex diets. Microdermabrasion sloughs away sun damage, scarring, and fine lines without any type of abrasive spray, and is followed by a rejuvenating serum rich in ceramides and vitamins A, C, and E. Laser vein-removal treatments cause blood vessels to fade rather than growing into unwanted tattoos. Amoderm Cosmetic and Wellness Medical Center keeps flesh looking youthful with their own line of skincare products, including an anti-aging sunscreen that fights free radicals as it protects skin from further damage.18 EndeavorIrvine, CA US
MYU BeautyRead MoreThe technicians at MYU Beauty don't just look at nails as canvases for color, but for three-dimensional designs as well. Flowers, jewels, and even Hello Kitty designs are just a few examples of the 3-D gel art that the staff can create. These designs can upgrade traditional manicures to multicolored galleries of rhinestones and holiday themes, such as ghosts for Halloween and stripes for the Fourth of July, a much prettier way to show American patriotism than replacing your shoes with apple pies. Those who opt for a smooth and simple manicure can still choose between LED-cured gels, which resist chipping, fading, and peeling for longer than standard polishes. The technicians conduct all of their nailcare with sanitized and disposable tools. For those hoping to launch their own cosmetic career, they also host classes on gel and gel-art techniques. Eyelash perms and permanent-makeup services round out the combination spa and beauty school's menu.17942 Sky Park Cir.Irvine, CA US
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Essence Nail StudioRead MoreFeel the pure essence of pampering, relaxation and beauty at Essence Nail Studio. Manicure and pedicure varieties are offered along with gel and acrylic nails. A full range of waxing services can be obtained by guests as well, including Brazilian and bikini waxes. Relieve tension with a shoulder massage from a trained professional. Extend short lashes with eyelash extensions. At Essence Nail Studio, guests are treated professionally and with courtesy. Upon entering, guests step into a brightly-lit and beautifully decorated area for nail service. Treatments can be scheduled by phone call, and staff will be happy to answer any questions. Those waiting in the lobby can free WiFi. As a perk complimentary wine is served to guests daily. Feel the essence of beauty and luxury at Essence Nail Studio.14131 Jeffrey RdIrvine, CA US
Hair by Rebecca RobertsRead MoreRebecca Roberts bills herself as a creative hairstylist with an eye for modernity. At her salon, she combines that creativity with expert technique to craft styles that complement each client's features and solve their hair concerns. Rebecca specializes in color, and she adds dimension to hair with a variety of treatments, including ombre highlights and full color. She even offers ultra-convenient "Drive-By Quickly-Color" services, which take just 5–10 minutes to process, thanks to a color accelerator. Beyond color, Rebecca also performs both classic and cutting-edge haircuts, and can revitalize hair with conditioning treatments or smooth locks with Brazilian Blowouts.19800 MacArthur BoulevardIrvine, CA US


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May is National Hamburger Month. Find out all you need to know about this backyard barbecue favorite.
At least one powerful bomb hit near the main train station in Ankara on Saturday morning, killing 30 people, authorities said, making it the deadliest attack in the Turkish capital in recent memory.
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Finding information in information technology and computing
The internet provides a world of information, but how do you find what you are looking...
The internet provides a world of information, but how do you find what you are looking for? This unit will help you discover the meaning of information quality and teach you how to evaluate the material you come across. You will learn how to plan your searches effectively and be able to experiment with some of the key resources in this area.
By the end of this guide you should be able to:
- conduct your own searches efficiently and effectively;
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- critically evaluate information from a variety of sources;
- understand the importance of organising your own information;
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- describe how to use bookmarks/favorites for web resources;
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- Duration 9 hours
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Finding information in information technology and computing
The internet provides a world of information, but how do you find what you are looking for? This unit will help you discover the meaning of information quality and teach you how to evaluate the material you come across. You will learn how to plan your searches effectively and be able to experiment with some of the key resources in this area.
This material is from our archive and is an adapted extract from Finding information (T324), which is no longer taught by The Open University. If you want to study formally with us, you may wish to explore other courses we offer in this subject area [Tip: hold Ctrl and click a link to open it in a new tab. (Hide tip)] .
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RICHMOND, Va. (AP) - The Virginia GOP-controlled House of Delegates passed a budget Tuesday and then mocked their Senate colleagues for having left town without passing a budget of their own.
After the House voted along party lines to pass a roughly $96 billion two-year budget late Tuesday, an ebullient group of Republican delegates walked their version of the budget over to present to an empty and darkened Senate chamber.
House Majority Leader Kirk Cox posted a sign reading "Gone Home" on the Senate's door, and the House's version of the budget was left on the floor. Several Republican lawmakers took turns posing for pictures by the sign.
The move was the latest in an ongoing and long-running public relations tussle between Republican and Democratic lawmakers over whether Virginia should undergo a large-scale expansion of its Medicaid program.
The General Assembly adjourned earlier this month without passing a budget because of the impasse on Medicaid, and there has been little sign the two sides are anywhere closer to an agreement than they were several months ago.
Democratic Gov. Terry McAuliffe and the Democrat-controlled Senate want to accept federal Medicaid funds in exchange for increasing the number low-income residents who would qualify for publicly assisted health insurance. Medicaid expansion is a key part of the Affordable Care Act, and the federal government has pledged to cover the full cost of expansion for the next three years. About half the states have opted to expand so far.
McAuliffe kicked off a special legislative session Monday by introducing a proposed budget that would limit Medicaid expansion to a two-year pilot program and tie the projected savings from Medicaid expansion, mostly from reduced state costs for indigent care, to a 2 percent pay raise for state employees, teachers and faculty.
The House immediately rejected McAuliffe's proposal in favor of a budget that does not include Medicaid expansion, while the Senate put off any budget action. The full Senate isn't scheduled to return to Richmond until April 7.
The GOP-controlled House opposes expanding the state's Medicaid program, which they say is growing at an unsustainable rate. And House Republicans have been insistent that Medicaid expansion be debated separate from the state's budget, a position rejected by McAuliffe and the Senate.
At a news conference earlier Tuesday, House Speaker William J. Howell criticized the Senate for not moving faster to pass its version of a budget so that negotiations between the two chambers can begin.
"The actions of the Democrats in the Senate yesterday clearly shows that they are not serious about getting a budget done," Howell said. "This is the most important thing we do as legislators."
State government could shut down if a budget is not passed by July 1.
But Senate Democratic Caucus Chairman A. Donald McEachin issued a statement saying Republicans were to blame for gridlock because they were refusing to negotiate on Medicaid expansion.
"Republicans keep talking about process, but they aren't addressing the actual problem," McEachin said.


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Everyone can learn from nursery rhymes, no matter your age. Some of these whimsical little poems give life lessons that can even be used to help you learn more about insurance! Here are 5nursery rhymes that can teach you about insurance. Itsy Bitsy Spider: Don't forget your flood insurance – The itsy bitsy spider had…
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Spring is in Full Swing! Do You Have Hartford Flood Insurance??
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Everyone should have, and absolutely needs, some type of Hartford flood insurance policy, regardless of their location. Floods can happen at a moment's notice,without any type of warning, and if you don't have the coverage, you'll find yourself up stream without a paddle. And trust me, you don't want to up this stream. So if you're someone…
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Paradiso Insurance Preparation Tips for Hurricane Earl
by paradisoinsurance • • 0 Comments
Paradiso Insurance strives to help our clients in any way possible. Today we bring you some tips on how to prepare your family, home, and possesions for the upcoming storm. These tips come from the Hurricane specialists, NOAA. 1. Develop a Family Plan Discuss the type of hazards that could affect your family. Know your…


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Volume 9, Issue 5, September 2015
- Preface
Preface to Special Topic: Microfluidics in Drug Delivery9(2015); http://dx.doi.org/10.1063/1.4931070View Description Hide Description
In this special topic of Biomicrofluidics, the importance of microfluidics in the field of drug delivery is highlighted. Different aspects from cell-drug carrier interactions, delivery vehicle assembly to novel drug delivery devices are considered. The contributing reviews and original articles illustrate the synergistic outcomes between these two areas of research with the aim to have a positive impact on biomedical applications.
- Contributed Articles
Sustained release of hydrophobic drugs by the microfluidic assembly of multistage microgel/poly (lactic-co-glycolic acid) nanoparticle composites9(2015); http://dx.doi.org/10.1063/1.4916230View Description Hide Description
The poor solubility of many newly discovered drugs has resulted in numerous challenges for the time-controlled release of therapeutics. In this study, an advanced drug delivery platform to encapsulate and deliver hydrophobic drugs, consisting of poly (lactic-co-glycolic acid) (PLGA) nanoparticles incorporated within poly (ethylene glycol) (PEG) microgels, was developed. PLGA nanoparticles were used as the hydrophobic drug carrier, while the PEG matrix functioned to slow down the drug release. Encapsulation of the hydrophobic agents was characterized by fluorescence detection of the hydrophobic dye Nile Red within the microgels. In addition, the microcomposites prepared via the droplet-based microfluidic technology showed size tunability and a monodisperse size distribution, along with improved release kinetics of the loaded cargo compared with bare PLGA nanoparticles. This composite system has potential as a universal delivery platform for a variety of hydrophobic molecules.
Evaporation-based microfluidic production of oil-free cell-containing hydrogel particles9(2015); http://dx.doi.org/10.1063/1.4916508View Description Hide Description
We demonstrate an evaporation-based microfluidic strategy to produce oil-free cell containing hydrogel particles. Perfluoro-n-pentane, which is used as the continuous oil phase to generate cell-containing hydrogel (Extracel) particles, is removed at an elevated temperature. Human colon cancer cells (HCT116) encapsulated in the hydrogel particles show higher viability than cells encapsulated in particles that are produced via a non-evaporative oil phase. In addition, single HCT116 cells can be cultured for a week in such particles and respond to inflammatory stimuli, highlighting the potential applications of the developed strategy for 3D cell culture, drug testing, and cell-based drug delivery.
Pulmonary monoclonal antibody delivery via a portable microfluidic nebulization platform9(2015); http://dx.doi.org/10.1063/1.4917181View Description Hide Description
Nebulizers have considerable advantages over conventional inhalers for pulmonary drug administration, particularly because they do not require coordinated breath actuation to generate and deliver the aerosols. Nevertheless, besides being less amenable to miniaturization and hence portability, some nebulizers are prone to denature macromolecular drugs due to the large forces generated during aerosolization. Here, we demonstrate a novel portable acoustomicrofluidic device capable of nebulizing epidermal growth factor receptor (EGFR) monoclonal antibodies into a fine aerosol mist with a mass median aerodynamic diameter of approximately 1.1 μm, optimal for deep lung deposition via inhalation. The nebulized monoclonal antibodies were tested for their stability, immunoactivity, and pharmacological properties, which confirmed that nebulization did not cause significant degradation of the antibody. In particular, flow cytometry demonstrated that the antigen binding capability of the antibody is retained and able to reduce phosphorylation in cells overexpressing the EGFR, indicating that the aerosols generated by the device were loaded with stable and active monoclonal antibodies. The delivery of antibodies via inhalation, particularly for the treatment of lung cancer, is thus expected to enhance the efficacy of this protein therapeutic by increasing the local concentration where they are needed.
Microfluidic based high throughput synthesis of lipid-polymer hybrid nanoparticles with tunable diameters9(2015); http://dx.doi.org/10.1063/1.4922957View Description Hide Description
Core-shell hybrid nanoparticles (NPs) for drug delivery have attracted numerous attentions due to their enhanced therapeutic efficacy and good biocompatibility. In this work, we fabricate a two-stage microfluidic chip to implement a high-throughput, one-step, and size-tunable synthesis of mono-disperse lipid-poly (lactic-co-glycolic acid) NPs. The size of hybrid NPs is tunable by varying the flow rates inside the two-stage microfluidic chip. To elucidate the mechanism of size-controllable generation of hybrid NPs, we observe the flow field in the microchannel with confocal microscope and perform the simulation by a numerical model. Both the experimental and numerical results indicate an enhanced mixing effect at high flow rate, thus resulting in the assembly of small and mono-disperse hybrid NPs. In vitro experiments show that the large hybrid NPs are more likely to be aggregated in serum and exhibit a lower cellular uptake efficacy than the small ones. This microfluidic chip shows great promise as a robust platform for optimization of nano drug delivery system.
Interaction between drug delivery vehicles and cells under the effect of shear stress9(2015); http://dx.doi.org/10.1063/1.4923324View Description Hide Description
Over the last decades, researchers have developed an ever greater and more ingenious variety of drug delivery vehicles (DDVs). This has made it possible to encapsulate a wide selection of therapeutic agents, ranging from proteins, enzymes, and peptides to hydrophilic and hydrophobic small drugs while, at the same time, allowing for drug release to be triggered through a diverse range of physical and chemical cues. While these advances are impressive, the field has been lacking behind in translating these systems into the clinic, mainly due to low predictability of in vitro and rodent in vivo models. An important factor within the complex and dynamic human in vivo environment is the shear flow observed within our circulatory system and many other tissues. Within this review, recent advances to leverage microfluidic devices to better mimic these conditions through novel in vitro assays are summarized. By grouping the discussion in three prominent classes of DDVs (lipidic and polymeric particles as well as inorganic nanoparticles), we hope to guide researchers within drug delivery into this exciting field and advance a further implementation of these assay systems within the development of DDVs.
Diffusion phenomena of cells and biomolecules in microfluidic devices9(2015); http://dx.doi.org/10.1063/1.4923263View Description Hide Description
Biomicrofluidics is an emerging field at the cross roads of microfluidics and life sciences which requires intensive research efforts in terms of introducing appropriate designs, production techniques, and analysis. The ultimate goal is to deliver innovative and cost-effective microfluidic devices to biotech, biomedical, and pharmaceutical industries. Therefore, creating an in-depth understanding of the transport phenomena of cells and biomolecules becomes vital and concurrently poses significant challenges. The present article outlines the recent advancements in diffusion phenomena of cells and biomolecules by highlighting transport principles from an engineering perspective, cell responses in microfluidic devices with emphases on diffusion- and flow-based microfluidic gradient platforms, macroscopic and microscopic approaches for investigating the diffusion phenomena of biomolecules, microfluidic platforms for the delivery of these molecules, as well as the state of the art in biological applications of mammalian cell responses and diffusion of biomolecules.
Artefacts at the liquid interface and their impact in miniaturized biochemical assay9(2015); http://dx.doi.org/10.1063/1.4927324View Description Hide Description
Droplet microfluidic technology has the potential to significantly reduce reagent use, and therefore, lower costs of assays employed in drug discovery campaigns. In addition to the reduction in costs, this technology can also reduce evaporation and contamination which are often problems seen in miniaturized microtitre plate formats. Despite these advantages, we currently advise caution in the use of these microfluidic approaches as there remains a lack of understanding of the artefacts of the systems such as reagent partitioning from droplet to carrier oil and interaction of the biological reagents with the water-oil interface. Both types of artefact can lead to inaccurate and misleading data. In this paper, we present a study of the partitioning of a number of drug-like molecules in a range of oils and evidence of protein binding at the water-oil interface which results in reduced activity of a cytochrome P450 enzyme. Data presented show that the drug-like molecules partitioned the least into fluorocarbon oils and the interaction of the 1A2 cytochrome at the water-oil interface resulted in a lower or complete absence of enzyme activity. This loss of activity of cytochrome 1A2 could be restored by the use of secondary blocking proteins although changes in the pharmacology of known 1A2 inhibitors were observed. The artefacts described here due to reagents partitioning into the carrier oil or protein binding at the water-oil interface significantly impact the potential use of these microfluidic systems as a means to carry out miniaturized biological assays, and further work is needed to understand the impact and reduction of these phenomena.
A remotely operated drug delivery system with an electrolytic pump and a thermo-responsive valve9(2015); http://dx.doi.org/10.1063/1.4927436View Description Hide Description
Implantable drug delivery devices are becoming attractive due to their abilities of targeted and controlled dose release. Currently, two important issues are functional lifetime and non-controlled drug diffusion. In this work, we present a drug delivery device combining an electrolytic pump and a thermo-responsive valve, which are both remotely controlled by an electromagnetic field (40.5 mT and 450 kHz). Our proposed device exhibits a novel operation mechanism for long-term therapeutic treatments using a solid drug in reservoir approach. Our device also prevents undesired drug liquid diffusions. When the electromagnetic field is on, the electrolysis-induced bubble drives the drug liquid towards the Poly (N-Isopropylacrylamide) (PNIPAM) valve that consists of PNIPAM and iron micro-particles. The heat generated by the iron micro-particles causes the PNIPAM to shrink, resulting in an open valve. When the electromagnetic field is turned off, the PNIPAM starts to swell. In the meantime, the bubbles are catalytically recombined into water, reducing the pressure inside the pumping chamber, which leads to the refilling of the fresh liquid from outside the device. A catalytic reformer is included, allowing more liquid refilling during the limited valve's closing time. The amount of body liquid that refills the drug reservoir can further dissolve the solid drug, forming a reproducible drug solution for the next dose. By repeatedly turning on and off the electromagnetic field, the drug dose can be cyclically released, and the exit port of the device is effectively controlled.
The role of acoustofluidics in targeted drug delivery9(2015); http://dx.doi.org/10.1063/1.4928947View Description Hide Description
With the fast development of acoustic systems in clinical and therapeutic applications, acoustically driven microbubbles have gained a prominent role as powerful tools to carry, transfer, direct, and target drug molecules in cells, tissues, and tumors in the expanding fields of targeted drug delivery and gene therapy. The aim of the present study is to establish a biocompatible acoustic microfluidic system and to demonstrate the generation of an acoustic field and its effects on microbubbles and biological cells in the microfluidic system. The acoustic field creates non-linear oscillations of the microbubble-clusters, which results in generation of shear stress on cells in such microsystems. This effectively helps in delivering extracellular probes in living cells by sonoporation. The sonoporation is investigated under the combined effects of acoustic stress and hydrodynamic stress during targeted drug and gene delivery.
Phospholipid—polymer amphiphile hybrid assemblies and their interaction with macrophages9(2015); http://dx.doi.org/10.1063/1.4929405View Description Hide Description
Recently, the combination of lipids and block copolymers has become an alternative to liposomes and polymersomes as nano-sized drug carriers. We synthesize novel block copolymers consisting of poly(cholesteryl acrylate) as the hydrophobic core and poly(N-isopropylacrylamide) (PNIPAAm) as the hydrophilic extensions. Their successful phospholipid-assisted assembly into vesicles is demonstrated using the evaporation-hydration method. The preserved thermo-responsive property of the lipid-polymer hybrids is shown by a temperature dependent adsorption behaviour of the vesicles to poly(l lysine) coated surfaces. As expected, the vesicle adsorption is found to be higher at elevated temperatures. The cellular uptake efficiency of hybrids is assessed using macrophages with applied shear stress. The amount of adhering macrophages is affected by the time and level of applied shear stress. Further, it is found that shorter PNIPAAm extensions lead to higher uptake of the assemblies by the macrophages with applied shear stress. No inherent cytotoxicity is observed at the tested conditions. Taken together, this first example of responsive lipid-polymer hybrids, and their positive biological evaluation makes them promising nano-sized drug carrier candidates.
Integrating plasmonic diagnostics and microfluidics9(2015); http://dx.doi.org/10.1063/1.4929579View Description Hide Description
Plasmonics is generally divided into two categories: surface plasmon resonance (SPR) of electromagnetic modes propagating along a (noble) metal/dielectric interface and localized SPRs (LSPRs) on nanoscopic metallic structures (particles, rods, shells, holes, etc.). Both optical transducer concepts can be combined with and integrated in microfluidic devices for biomolecular analyte detections, with the benefits of small foot-print for point-of-care detection, low-cost for one-time disposal, and ease of being integrated into an array format. The key technologies in such integration include the plasmonic chip, microfluidic channel fabrication, surface bio-functionalization, and selection of the detection scheme, which are selected according to the specifics of the targeting analytes. This paper demonstrates a few examples of the many versions of how to combine plasmonics and integrated microfluidics, using different plasmonic generation mechanisms for different analyte detections. One example is a DNA sensor array using a gold film as substrate and surface plasmon fluorescence spectroscopy and microscopy as the transduction method. This is then compared to grating-coupled SPR for poly(ethylene glycol) thiol interaction detected by angle interrogation, gold nanohole based LSPR chip for biotin-strepavidin detection by wavelength shift, and gold nanoholes/nanopillars for the detection of prostate specific antigen by quantum dot labels excited by the LSPR. Our experimental results exemplified that the plasmonic integrated microfluidics is a promising tool for understanding the biomolecular interactions and molecular recognition process as well as biosensing, especially for on-site or point-of-care diagnostics.
Piezoelectric-driven droplet impact printing with an interchangeable microfluidic cartridge9(2015); http://dx.doi.org/10.1063/1.4928298View Description Hide Description
Microfluidic impact printing has been recently introduced, utilizing its nature of simple device architecture, low cost, non-contamination, and scalable multiplexability and high throughput. In this paper, we have introduced an impact-based droplet printing platform utilizing a simple plug-and-play microfluidic cartridge driven by piezoelectric actuators. Such a customizable printing system allows for ultrafine control of droplet volume from picoliters (∼23 pl) to nanoliters (∼10 nl), a 500 fold variation. The high flexibility of droplet generation can be simply achieved by controlling the magnitude of actuation (e.g., driving voltage) and the waveform shape of actuation pulses, in addition to nozzle size restrictions. Detailed printing characterizations on these parameters have been conducted consecutively. A multiplexed impact printing system has been prototyped and demonstrated to provide the functions of single-droplet jetting and droplet multiplexing as well as concentration gradient generation. Moreover, a generic biological assay has also been tested and validated on this printing platform. Therefore, the microfluidic droplet printing system could be of potential value to establish multiplexed micro reactors for high-throughput life science applications.
Flow of DNA solutions in a microfluidic gradual contraction9(2015); http://dx.doi.org/10.1063/1.4929927View Description Hide Description
The flow of λ-DNA solutions in a gradual micro-contraction was investigated using direct measurement techniques. The effects on DNA transport in microscale flows are significant because the flow behavior is influenced by macromolecular conformations, both viscous and elastic forces dominate inertial forces at this length scale, and the fully extended length of the molecule approaches the characteristic channel length wc (L/wc ∼ 0.13). This study examines the flow of semi-dilute and entangled DNA solutions in a gradual planar micro-contraction for low Reynolds numbers (3.7 × 10−6 < Re < 3.1 × 10−1) and high Weissenberg numbers (0.4 < Wi < 446). The semi-dilute DNA solutions have modest elasticity number, El = Wi/Re = 55, and do not exhibit viscoelastic behavior. For the entangled DNA solutions, we access high elasticity numbers (7.9 × 103 < El < 6.0 × 105). Video microscopy and streak images of entangled DNA solution flow reveal highly elastic behavior evidenced by the presence of large, stable vortices symmetric about the centerline and upstream of the channel entrance. Micro-particle image velocimetry measurements are used to obtain high resolution, quantitative velocity measurements of the vortex growth in this micro-contraction flow. These direct measurements provide a deeper understanding of the underlying physics of macromolecular transport in microfluidic flow, which will enable the realization of enhanced designs of lab-on-a-chip systems.
A pump-free membrane-controlled perfusion microfluidic platform9(2015); http://dx.doi.org/10.1063/1.4930120View Description Hide Description
In this article, we present a microfluidic platform for passive fluid pumping for pump-free perfusion cell culture, cell-based assay, and chemical applications. By adapting the passive membrane-controlled pumping principle from the previously developed perfusion microplate, which utilizes a combination of hydrostatic pressure generated by different liquid levels in the wells and fluid wicking through narrow strips of a porous membrane connecting the wells to generate fluid flow, a series of pump-free membrane-controlled perfusion microfluidic devices was developed and their use for pump-free perfusion cell culture and cell-based assays was demonstrated. Each pump-free membrane-controlled perfusion microfluidic device comprises at least three basic components: an open well for generating fluid flow, a micron-sized deep chamber/channel for cell culture or for fluid connection, and a wettable porous membrane for controlling the fluid flow. Each component is fluidically connected either by the porous membrane or by the micron-sized deep chamber/channel. By adapting and incorporating the passive membrane-controlled pumping principle into microfluidic devices, all the benefits of microfluidic technologies, such as small sample volumes, fast and efficient fluid exchanges, and fluid properties at the micro-scale, can be fully taken advantage of with this pump-free membrane-controlled perfusion microfluidic platform.
Dielectrophoretic capture of low abundance cell population using thick electrodes9(2015); http://dx.doi.org/10.1063/1.4928703View Description Hide Description
Enrichment of rare cell populations such as Circulating Tumor Cells (CTCs) is a critical step before performing analysis. This paper presents a polymeric microfluidic device with integrated thick Carbon-PolyDimethylSiloxane composite (C-PDMS) electrodes designed to carry out dielectrophoretic (DEP) trapping of low abundance biological cells. Such conductive composite material presents advantages over metallic structures. Indeed, as it combines properties of both the matrix and doping particles, C-PDMS allows the easy and fast integration of conductive microstructures using a soft-lithography approach while preserving O2 plasma bonding properties of PDMS substrate and avoiding a cumbersome alignment procedure. Here, we first performed numerical simulations to demonstrate the advantage of such thick C-PDMS electrodes over a coplanar electrode configuration. It is well established that dielectrophoretic force ( ) decreases quickly as the distance from the electrode surface increases resulting in coplanar configuration to a low trapping efficiency at high flow rate. Here, we showed quantitatively that by using electrodes as thick as a microchannel height, it is possible to extend the DEP force influence in the whole volume of the channel compared to coplanar electrode configuration and maintaining high trapping efficiency while increasing the throughput. This model was then used to numerically optimize a thick C-PDMS electrode configuration in terms of trapping efficiency. Then, optimized microfluidic configurations were fabricated and tested at various flow rates for the trapping of MDA-MB-231 breast cancer cell line. We reached trapping efficiencies of 97% at 20 μl/h and 78.7% at 80 μl/h, for 100 μm thick electrodes. Finally, we applied our device to the separation and localized trapping of CTCs (MDA-MB-231) from a red blood cells sample (concentration ratio of 1:10).
Microfluidic chemical processing with on-chip washing by deterministic lateral displacement arrays with separator walls9(2015); http://dx.doi.org/10.1063/1.4930863View Description Hide Description
We describe a microfluidic device for on-chip chemical processing, such as staining, and subsequent washing of cells. The paper introduces "separator walls" to increase the on-chip incubation time and to improve the quality of washing. Cells of interest are concentrated into a treatment stream of chemical reagents at the first separator wall for extended on-chip incubation without causing excess contamination at the output due to diffusion of the unreacted treatment chemicals, and then are directed to the washing stream before final collections. The second separator wall further reduces the output contamination from diffusion to the washing stream. With this approach, we demonstrate on-chip leukocyte staining with Rhodamine 6G and washing. The results suggest that other conventional biological and analytical processes could be replaced by the proposed device.
Microfluidic point-of-care blood panel based on a novel technique: Reversible electroosmotic flow9(2015); http://dx.doi.org/10.1063/1.4930865View Description Hide Description
A wide range of diseases and conditions are monitored or diagnosed from blood plasma, but the ability to analyze a whole blood sample with the requirements for a point-of-care device, such as robustness, user-friendliness, and simple handling, remains unmet. Microfluidics technology offers the possibility not only to work fresh thumb-pricked whole blood but also to maximize the amount of the obtained plasma from the initial sample and therefore the possibility to implement multiple tests in a single cartridge. The microfluidic design presented in this paper is a combination of cross-flow filtration with a reversible electroosmotic flow that prevents clogging at the filter entrance and maximizes the amount of separated plasma. The main advantage of this design is its efficiency, since from a small amount of sample (a single droplet 10 μl) almost 10% of this (approx 1 μl) is extracted and collected with high purity (more than 99%) in a reasonable time (5–8 min). To validate the quality and quantity of the separated plasma and to show its potential as a clinical tool, the microfluidic chip has been combined with lateral flow immunochromatography technology to perform a qualitative detection of the thyroid-stimulating hormone and a blood panel for measuring cardiac Troponin and Creatine Kinase MB. The results from the microfluidic system are comparable to previous commercial lateral flow assays that required more sample for implementing fewer tests.
Generation of murine induced pluripotent stem cells by using high-density distributed electrodes network9(2015); http://dx.doi.org/10.1063/1.4930866View Description Hide Description
This study reports a robust method of gene transfection in a murine primary cell model by using a high-density electrodes network (HDEN). By demonstrating high cell viability after gene transfection and successful expression of transgenes including fluorescent proteins, the HDEN device shows great promise as a solution in which reprogramming efficiency using non-viral induction for generation of murine induced pluripotent stem cells (iPSCs) is optimized. High and steady transgene expression levels in host cells of iPSCs can be demonstrated using this method. Moreover, the HDEN device achieved successful gene transfection with a low voltage of less than 180 V while requiring relatively low cell numbers (less than 1.5 × 104 cells). The results are comparable to current conventional methods, demonstrating a reasonable fluorescent-plasmid transfection rate (42.4% in single transfection and 24.5% in triple transfection) and high cell viability of over 95%. The gene expression levels of each iPSC factor was measured to be over 10-fold higher than that reported in previous studies using a single mouse embryonic fibroblast cell. Our results demonstrate that the generation of iPSCs using HDEN transfection of plasmid DNA may be a feasible and safe alternative to using viral transfection methods in the near future.
An off-the-shelf integrated microfluidic device comprising self-assembled monolayers for protein array experiments9(2015); http://dx.doi.org/10.1063/1.4930982View Description Hide Description
Microfluidic-based protein arrays are promising tools for life sciences, with increased sensitivity and specificity. One of the drawbacks of this technology is the need to create fresh surface chemistry for protein immobilization at the beginning of each experiment. In this work, we attempted to include the process of surface functionalization as part of the fabrication of the device, which would substitute the time consuming step of surface functionalization at the beginning of each protein array experiment. To this end, we employed a novel surface modification using self-assembled monolayers (SAMs) to immobilize biomolecules within the channels of a polydimethylsiloxane (PDMS) integrated microfluidic device. As a model, we present a general method for depositing siloxane-anchored SAMs, with 1-undecyl-thioacetate-trichlorosilane (C11TA) on the silica surfaces. The process involved developing PDMS-compatible conditions for both SAM deposition and functional group activation. We successfully demonstrated the ability to produce, within an integrated microfluidic channel, a C11TA monolayer with a covalently conjugated antibody. The antibody could then bind its antigen with a high signal to background ratio. We further demonstrated that the antibody was still active after storage of the device for a week. Integration of the surface chemistry into the device as part of its fabrication process has potential to significantly simplify and shorten many experimental procedures involving microfluidic–based protein arrays. In turn, this will allow for broader dissemination of this important technology.


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The days of Manteca's cramped, outdated animal shelter are numbered.
For the second year in a row, 15-year-old Jessica Munoz has been accepted into the Manteca Unified's All-District Honor Band.
Manteca's image and the safety of its residents are at the heart of a proactive campaign being launched this month by municipal code enforcement officers.
RIPON – A sign of growth for any community is the need for more public transportation.
Who is the best aerobics instructor or personal trainer in Manteca?
Soda can tops and pairs of old glasses are nothing more than junk to most folks.
Nominations are being sought for the Manteca Hall of Fame's Class of 2011.
Love INC, a nonprofit organization in Manteca whose mission is to extend a hand-up to individuals and families who need the help, is holding a fund-raiser on Valentine's Day.
LATHROP – Michael Berchtold, a former third-grade teacher at Joseph Widmer, Jr. Elementary School in Lathrop, has won a new chance at seeking justice and clearing his name.
LATHROP – Henrietta Anguiano, a widow and a great-great-grandmother who is well known for her volunteer work at her church and in the community, was one of three women in San Joaquin County who was inducted into the2010 Adelita Awards of the Mexican Heritage Center in Stockton Saturday night.
Manteca continued to dominate the Northern San Joaquin Valley new housing market with 345 homes built in 2010.
Manteca leaders plan to show folks "the money" to get the message about why the community should embrace Great Wolf Resort back on course.
Manteca is poised to invest $1.6 million in municipal parks during the coming months.
Manteca has a plan to turn green waste into green backs.
Sending boys to summer camp is the No. 1 goal behind an annual community fundraising campaign by the Friends of Scouting, according to its chairman, John Coburn, senior vice president of Oak Valley Community Bank.
Page 518 of 805
There are more than 300 high school juniors and seniors in Manteca Unified preparing for the future by learning how to do everything from making ...
A Little Free Library is open to all comers on North Street across from Doctors Hospital of Manteca.
In February former Manteca Unified Trustee Dale Fritchen demanded that the Board of Education cease violating California's open meetings law.
The bleachers in the new Multi-Purpose Room still need to be installed.
This year's Fourth of July was a three-day endeavor.
Social Security has provided critical financial help to people of all ages for the last 80 years, and despite our age, we're far from ...
Seniors Helping Area Residents and Police (SHARP) volunteers pick up between 100 and 125 abandoned shopping carts a month on the streets of Manteca.
Sometimes problems create a better solution.
Manteca's first multiple-family development designed from the start as condos may be built along a western extension of Center Street.
It can take six months for a problem reported along the side of Interstate 5 to be addressed by Caltrans.
A "Brunch of Hope" in memory of Alice Umbalin is a special fundraiser for ovarian cancer education and outreach set for Saturday, Sept. 19 from ...
Trustee Ashley Drain called it "garbage."
It was the night the lights shined on the Ripon Christian Athletic Stadium.
Editor's note: This is the first of an occasional series on family businesses where multi-generations work together.
There might be a few changes to the Lathrop Relay for Life but the crux of the mission remains the same.
Page 20 of 22
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This fragrance is about to be discontinued. Les Senteurs tell me that it is no longer in production. Such a shame as it is a truly lovely perfume.
16th July, 2008
Basenotes is an online guide to perfume and fragrance, featuring news, a database of fragrances, perfume glossary, fragrance forums, user reviews and more.


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Kryptos photo via Wikimedia Commons
Kryptos is an encrypted sculpture installed at CIA headquarters in Langley, Virginia. It's a set of huge copper plates with enciphered text carved into them -- for example, one segment reads TWTQSJQSSEKZZWATJKLUDIAWINFBNYP, though it looks a lot nicer in context.
Although the sculpture was installed in 1990, it took until 1999 for someone to actually decrypt part of the message: of the four segments of text, three were decrypted (complete with intentional... READ ON
Paul Erd?s was a mathematician. In addition to authoring significant papers himself, he created a series of Erd?s problems in which he offered (often small) cash prizes for solutions to difficult and/or significant mathematical challenges. He also had a great affinity for amphetamines, lived out of a suitcase, and drank endless coffee. This combo of genius, substance abuse, and intentional homelessness creates a pretty colorful character.
The hour-long documentary N Is a Number (shown below in its... READ ON
When I want to add two numbers, I use a calculator. Made of metal. But if you're the awesome woodworker Matthias Wandel, you build a binary adding machine out of wood, then drop marbles into it in order to get your result. BEHOLD, THE WOODEN ADDING MACHINE:
My favorite part is when he gets to the bit representing the number 64 -- the machine's registers literally overflow, resetting the machine's state. You guys, all those years of computer science classes suddenly make sense now.
Wandel has... READ ON
Missile engineer Destin (last name undisclosed) made waves a few weeks back with his video explaining Why Cats Usually Land on Their Feet. His YouTube channel is full of great stuff -- here are some favorites to make you, yes, a little smarter every day.
Eliminating "Poop Splash"
"Is there a way we can eliminate...poop splash?" This is surprisingly clean for a video involving "fecal simulants." Around 2:40 the answer is revealed. SCIENCE IN ACTION! As Destin's wife says, "You're welcome."... READ ON
Why do cats (usually) land on their feet? In the six-minute video below, missile engineer and last-name-avoider Destin explains...and includes some real stunt-cat dropping photographed with a high-speed camera. He also has archival footage of Air Force researchers dropping cats on parabolic flights, which helps explain the physics behind the phenomenon. As far as I can tell, no cats were harmed in the making of this video -- though they seemed, at the very least, displeased.
For some deeper math,... READ ON
George Hart shows us how to cut a bagel such that it ends up as two linked bagel-rings. His knife follows the surface of a two-twist Möbius strip, making use of the initial bagel's ring shape to tease the second ring out of it. Hart then proceeds to show us how to toast it, and asks the tantalizing question: how much more cream cheese can you get on this cut bagel, versus a traditional cut? Not being a mathemagician, I'll let y'all talk that one through in the comments.
My favorite YouTube comment:... READ ON
July 22 is Pi Approximation Day because pi's fractional approximation is 22/7. To celebrate, here are some math foods Miss C rounded up last year.
Food is often used to illustrate shapes, and recipes are used to introduce children to measurement and proportions. But if you really care about your mathematics -and your food- there are ways to take the marriage of math and food to the next level!
Pi... READ ON
Today's math/science nerd party: George Hart demonstrates how a set of magnetized square shapes will self-organize into a cube, when placed inside a plastic bag and shaken. This behavior arises because the magnets themselves (due to their polarity and configuration) trend towards cube-ness. I think I just learned kung fu.
Bonus points: George Hart is Vi Hart's dad. A family of awesome math video... READ ON
Alex Dainis has grapheme to color synesthesia, meaning that within her brain, numbers have strong associations with colors -- "each number has its own color, or personality," she explains. We've covered synesthesia previously, but this is the first time I've seen a synesthete sit down and describe concretely, in a non-artsy-fartsy way, what's going on in her brain.
It's really interesting how Dainis tries to explain the logic behind the number-coloring. This logic isn't entirely consistent, it just... READ ON
Vi Hart makes videos primarily about math (we've written about her before). But how does she make the videos? The typical Vi Hart video involves a lot of drawing, ultra-fast narration, quick cuts, and fast-motion video. Finally, after years of making videos, Vi Hart has made a video about making videos. But making that video entails making a script for that video, which means that within the script, the future is the present referring to itself as the past, so the video gets a little...meta. So... READ ON
Presidential retreat Camp David is named after Dwight Eisenhower's grandson.


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Memo to Kashmiri Militants: Don't Hide in Bear Caves
November 04, 2009
A bear mauled two Muslim separatists after finding them in its den, the BBC reports.
Nice Guys Finish Last
November 03, 2009
If Creigh Deeds loses today—and few candidates have hoisted themselves out of the kind of hole he's dug—let it be known that the Commonwealth of Virginia missed out on having a very nice man in Richmond. "When you elect a governor, you elect not only their positions, but you elect their character, their heart," declared Senator Mark Warner, to a gamely cheering crowd of about 150 in Alexandria's Market Square last night.
Was Creigh Deeds's Fatal Error Being Himself?
November 02, 2009
Whenever I read the words, "You're not from around here, are you?" I automatically imagine them being said with a serious Southern--or at least rural--twang.
Update: Hillary Backpedals in Pakistan
October 30, 2009
So much for getting tough. No sooner had I finished praising her tough talk in Pakistan than she began walking it back. Clinton carefully scaled back her comments from a day earlier suggesting that some Pakistani officials knew where al-Qaida's upper echelon has been hiding and have done little to target them. When the U.S.
Seeing and Believing
October 30, 2009
Are representations of the Prophet Muhammad permitted in Islam? To make or not to make images of the Prophet: that is the question I will try to answer. It is an unexpectedly burning question, as the newspapers regularly demonstrate. But both the answer to the question and the reasons for raising it require a broader introduction. There have been many times in recent years when one bemoaned the explosion of media that have provided public forums for so much incompetence and ignorance, not to speak of prejudice. Matters became worse after September 11, for two additional reasons.
More On J Street's Choice
October 29, 2009
When I argued at the J Street Conference that J Street couldn't simultaneously appeal to people with Walt/Mearsheimer-esque views on Israel and a significant chunk of the American Jewish population, one of the names I cited as an example of the former was Phillip "The U.S. Without Israel is Like A Fish Without A Bicycle" Weiss, who writes for the Nation.
Does the Name John Brady Kiesling Ring a Bell?
October 27, 2009
In case it doesn't and your memory needs refreshing, he's the career diplomat who resigned in protest from the State Department in 2003 on the eve of the Iraq War. I bring up Kiesling because, despite all the hubbub over foreign service officer Matthew Hoh's resignation in protest over our Afghanistan policy, I'd imagine he'll become a historical footnote like Kiesling and his action will have little impact on the direction of the Obama administration's Afghanistan policy.
A Propaganda Defeat in Afghanistan
October 27, 2009
I hadn't been aware of the uproar in Afghanistan over the alleged desecration of a koran by American forces until the Washington Post flagged it in passing this morning. It's a reminder that the Taliban can match our guns and helicopters with some equally powerful lies.
The Race Man
October 26, 2009
Up from History: The Life of Booker T. Washington By Robert J. Norrell (Harvard University Press, 508 pp., $35) I. Once the most famous and influential African American in the United States (and probably the world), Booker T. Washington has earned at best mixed reviews in the decades since his death in 1915. Black intellectuals and political activists, from W. E. B.
End State
October 26, 2009
California is a mess, but I love it all the same--especially the Bay Area, where I lived for 15 years. I went to Berkeley in 1962--a refugee from Amherst College, which at that time was dominated by frat boys with high SAT scores. I didn't go to Berkeley to go to school, but to be a bus ride away from North Beach and the Jazz Workshop. In a broader sense, I went to California for the same reason that other émigrés had been going since the 1840s. I was knocking on the Golden Door. Immigrants from Europe had come to America seeking happiness and a break with their unhappy pasts.


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All posts tagged "britney spears"
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Britney Spears takes to the pages of V Magazine's latest issue out on newsstands now. Photographed by Mario Testino and styled...2011March 3, 2011
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Britney Spears photographed by Todd Cole for POP F/W 2010, makeup by Yumi and set design by Peter Klein (TFS)2010August 24, 2010


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The last thirty years, though as dates go this is only an approximation, have witnessed a marked development of religious cults and movements largely outside the lines of historic Catholicism and Protestantism. One of these cults is strongly organized and has for twenty years grown more rapidly in proportion than most of the Christian communions. The influence of others, more loosely organized, is far reaching. Some of them attempt to give a religious content to the present trend of science and philosophy, and, generally, they represent the free movement of what one may call the creative religious consciousness of our time.
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Decades ago, a substantial element of mainstream white culture in the United States was dysfunctional because it embraced discrimination against minorities. This was not only wrong, but self-defeating. White communities that most fully embraced racial animosity were among the most backward and poverty-stricken in the country.
Now a substantial element of mainstream black culture in the United States is dysfunctional because it embraces an irrational sense of victimhood and helplessness. If every problem and tragic event that besets the black community is a result of oppression, then there is no reason for members of that community to take responsibility for and learn from outcomes and personal experience.
A useful, constructive take-away from the Trayvon Martin tragedy is this: People should do everything possible to avoid unnecessary violent confrontations with others, because such confrontations can turn tragic in an instant. This is an actionable concept that individuals can apply to make future tragedies less likely. A useless, destructive and false take-away is that the tragedy was a result of generalized racial oppression. Teaching people to feel victimized promotes a sense of helplessness and anger that makes future tragedies more likely, not less.
Besides, "America" did not kill Trayvon Martin, George Zimmerman did. While there is proof that Mr. Zimmerman set events in motion with his decision to follow the teenager, there is no proof that he was motivated by racism. There is also no way to know who escalated the confrontation to the level of violence. In all likelihood, it was the violence, not race, that was the tipping point for this tragedy.
There is no way to know at this point, but I think that if an unfamiliar white teenager had been walking through that neighborhood with the same dress and demeanor as Trayvon, Mr. Zimmerman would have followed him, too. And if the same physical altercation had ensued, the white teenager would have died as well. I would also bet that one could, if so inclined, find multiple incidences of white adult men shooting white teenagers in circumstances similar to the Trayvon Martin case. But that would not reinforce the template of "racist America."
Mililani, Hawaii


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note all its own. If the farmer and country merchant, who had passed through the abstract stage of political aspiration with the Jeffersonian democratic movement, were now, with Jackson, reaching out for the material advantages which political power might yield, the wage earners, being as yet novices in politics, naturally were more strongly impressed with that aspect of the democratic upheaval which emphasized the rights of man in general and social equality in particular. If the middle class Jacksonian was probably thinking first of reducing the debt on his farm or perchance of getting a political office, and only as an after-thought proceeding to look for a justification in the Declaration of Independence, as yet the wage earner was starting with the abstract notion of equal citizenship as contained in the Declaration, and only then proceeding to search for the remedies which would square reality with the idea. Hence it was that the aspiration toward equal citizenship became the keynote of labor's earliest
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Mon, 21/01/2013 - 11:43
LGT Capital Partners has won a GBP280m multi-alternatives mandate from Hertfordshire County Council.
Mon, 21/01/2013 - 10:44
Hedge funds, as measured by the Dow Jones Credit Suisse Hedge Fund Index, finished December up 1.48 per cent.
Mon, 21/01/2013 - 10:06
Steady inflows and performance-based gains increased hedge fund assets by USD60bn in the fourth quarter, bringing total industry capital to a record USD2.25trn, according to the latest HFR Global Hedge Fund Industry Report.
Mon, 21/01/2013 - 06:11
Carne Group, the global fund governance specialist, has welcomed the consultation initiative and the decision by the Cayman Islands Monetary Authority (CIMA) to enhance and clarify corporate governance standards for the Cayman Islands funds community.
Mon, 21/01/2013 - 06:05
Optimism among investment managers rose for the fourth successive quarter as business volumes and incomes grew again, according to the latest CBI/PwC Financial Services Survey.
Fri, 18/01/2013 - 14:09
Clearstream and Belfius have agreed to develop a new collateral management activity for bilateral trades, focusing on over-the-counter (OTC) derivatives and aimed primarily at corporates and medium-sized banks.
Fri, 18/01/2013 - 11:38
GAIN Capital, a provider of online trading services, has appointed Joe Wald as executive vice president, head of institutional.
Fri, 18/01/2013 - 11:35
The Hatteras Managed Futures Strategies Fund from boutique alternative investment specialist Hatteras Funds is now available on the Charles Schwab Mutual Fund OneSource Platform.
Fri, 18/01/2013 - 09:51
Eurex Repo, the marketplace for international, electronic repo trading and secured funding, plans to extend the maximum term of tradable securities for the Eurex Repo markets such as GC Pooling and Euro Repo.
Fri, 18/01/2013 - 06:08
Krusen Capital Management has formed a partnership with Meeschaert Group to provide clients with alternatives advisory services, manager and strategy due diligence, and access to a platform of alternative investment solutions.
Fri, 09 Oct 2015 00:00:00 GMT
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text:
Music and health benefits
While music has long been understood as an effective type of treatment to offer an outlet for emotions, the view of using tune, sound frequencies and beat to take care of physical ailments is a comparatively new realm, says psychologist Daniel J. Levitin, PhD, who examines the neuroscience of music at McGill University in Montreal. An abundance of new studies is touting the advantages of music on physical as well as mental health. For instance, in a meta-evaluation of Levitin 400 studies and his postgraduate research fellow, PhD, Mona Lisa Chanda, found that music reduces anxiety and enhances the entire body's immune system function. Listening to music was likewise found to be more efficient than prescription drugs in reducing stress before operation (Trends in Cognitive Sciences, April, 2013).
"We have found convincing evidence that musical interventions can play a healthcare job in settings that range from operating rooms to family practices," says Levitin, writer of the novel "This is Your Brain on Music" (Plume/Penguin, 2007). The evaluation also points to health is influenced by music. Music additionally reduces levels of the stress hormone cortisol.
"This is one reason why music is related to easiness," Levitin says.
"There's growing scientific evidence demonstrating the brain reacts to music in quite unique ways," says Lisa Hartling, PhD, professor of pediatrics in the University of Alberta and lead author of the study. "Playing music for children during painful medical procedures is an easy intervention that could make a significant change."
Mature patients can be helped by music, also. Music therapists worked with the patients to independently tailor the intervention, and patients took part in lyric dialogue, instrument playing, singing and song writing as they worked toward accepting an illness or considered end-of-life problems.
"Active music booking enabled the patients to reconnect together with the healthy elements of themselves, even in the surface of a debilitating illness or disorder-associated anguish," says music therapist Melanie Kwan, coauthor of the study and president of the Association for Music Therapy, Singapore. "When their acute pain symptoms were alleviated, patients were eventually able to rest.


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Funny: You Bet Your Life
It's Groucho Marx, people.
- 1950-60: The "Stag Reels", shown at the sponsors' conventions and released in the Shout Factory DVD sets. There's a reason those bits didn't air.
- 1950s: Groucho asks a woman about her husband.
Woman: Oh boy, have you ever been made love to by a Frenchman?Groucho (flustered): Not...not that I can recall!
- 1956-57: The Secret Word Duck once landed directly on George Fenneman's head, a moment that went into several of the aforementioned Stag Reels.
- From the Cosby era, a woman confuses Bill from North, South Carolina and back.


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Rosie Huntington-Whiteley
Rosie Huntington-Whiteley in Pierre Balmain Zip Skinny Jeans
Rosie Huntington-Whiteley was spotted catching a flight out of Los Angeles at LAX Airport. The model/actress pulled out her Pierre Balmain Zip Skinny jeans to pair with some IRO boots and a Gucci bag.
It's great to see Rosie back in these jeans. They are one of my favorite pair of jeans that I have seen her in and, of course, because I am obsessed with bleached washes right now. Even with the strong details, I find these to be a timeless and versatile pair. You can click here to purchase Pierre Balmain from Shopbop.
Rosie Huntington-Whiteley in Etoile Isabel Marant Ivo Cords
Rosie Huntington-Whiteley was spotted arriving in Nice, France with boyfriend Jason Statham. She wore a pair of the Etoile Isabel Marant Ivo Cords with her staple color, camel, and a fedora.
I have to admit that this is the first outfit that I have seen on Rosie that I am not to crazed about. There is something about the slingback pumps that I find makes it feel odd. But these pants are still one of my favorites that Isabel Marant has designed and the fit is no exception to the "everything looks good on Rosie" saying. You can click here to purchase Etoile Isabel Marant from FORWARDbyelysewalker.
Images Courtesy of WENN.com
Rosie Huntington-Whiteley in AG Adriano Goldschmied The Legging Ankle
This is a rare sighting. Not of Rosie Huntington-Whiteley of course, but of her in London. The actress/model was caught leaving a friends house. She wore a pair of AG Ankle Leggings in 17 Years Western Studded with a Mary Katrantzou blazer and some nude patent pumps. She then finished it off with her signature fedora.
The wash of these jeans alone has that perfect light blue wash that AG has perfected and they also have some great detail on them. The studs are prominent without overpowering the jeans themselves. They also just fit Rosie to perfection. It's either she got them tailored or she was genetically blessed with a shape that suits everything. You can click here to purchase these jeans from the AG website for $225.
Images Courtesy of WENN.com
Rosie Huntington-Whiteley in Anine Bing Suede Zip Leggings
Rosie Huntington-Whiteley was spotted celebrating her birthday in London. The model wore a pair of Anine Bing Suede Zip Leggings with some Jimmy Choo pumps and a navy blazer.
I have been waiting to catch Rosie in Anine Bing, especially one of the leather/suede pieces. I hope to see her wear the Skinny Leather Pants or the Double Zip Charcoal Skinny next. Those are one of my favorite pants Anine has designed and I'm still dying to try them out. I hope to see her release those in more color ways and maybe even suede. You can click here to purchase these leggings from the Anine Bing website for $699.


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Nice to meet you here at ringtones service Audiko.net, where it's possible to find the most popular ringtones for your ringer. Today we have a ringtone of "Alpha Beta Gaga" by Air as well as 955 other ringtones by Air. "Alpha Beta Gaga" is one of the best tracks from the "Talkie Walkie" album that was created by Air at their recording studio together with other 21 tracks. You can listen to all 5 Air – "Alpha Beta Gaga" ringtone variations available here and download it for free directly to your mobile. You can also explore other 13 albums produced by Air for all time. "Alpha Beta Gaga" is referred to Electronic, and we have a huge amount of Electronic compilations absolutely for free. And finally, we have collected lyrics for this track and you can view it here as well. So feel free to browse, listen, download ringtones at Audiko.net. Make your phone sound cool!
Air Alpha Beta Gaga Ringtone
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- Breaking Bad - Lydia
- ring - New Ringtone 1
- tragedie - Tragedie - OH
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Re: Memorable International Performances
Expand Messages
- Shelley wrote regarding the Thorobreds in Chicago in '66: "That had never
been done before and it started our society on the road to choreography."
Well, choreography actually got started a few years before Joe Wise and Jim
Miller marched the Thorobreds around the stage so skillfully in Chicago. I
believe it was in Columbus in '58 when the host chapter Singing Buckeyes did
some marching of their own on the song "Gee Boys It's Great to Lead a Band."
Distinguished barbershopper and bass of the Buzz Saws, the late George
Chamblin, often proclaimed that was the first "real" choreography used by a
chorus in contest.
Take nothing away from the boys from Louisville. Their performance in '66
was definitely one of the most memorable I have witnessed.
Paul Shannon
Zanesville (JAD)
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text:
Startup News – sorted by country
Recent JobsHead of Technology at TawiPay - Lausanne, Switzerland
iOS and Android Opportunities at fleetster - Munich, Germany
Space Manager (m/f) at Mindspace - Berlin, Germany
NLP Engineer at AYLIEN - Dublin, Ireland
Recent Comments
- Perry Oostdam on Recruitee – probably the fastest seed funding after appearing on Product Hunt
- Ieva on The hottest European travel startups in 2015
- Ochs on The 15 hottest European fintech startups in 2015
- Miguel Daniels on Equity crowdfunding deals of May: learn Chinese online, hummus restaurants in London, cross platform strategy games
Tag Archives: Lausanne
Lausanne-based BugBuster secures €815k
BugBuster, a startup in the field of smart bug detection for software, has just closed its Series A financing round worth about € 815,000. Investors are a consortium led by BAS (Business Angels Switzerland) with Polytech Ventures, the Hasler Foundation, … Continue reading
Posted in Funding, Switzerland-Startups Tagged BAS, bug detection, BugBuster, Lausanne, Polytech Ventures, Series A Comments Off
Paper.li secures $2m in a new round of funding
Paper.li, a project of the Lausanne-based startup SmallRivers, has just attracted additional $2 million of new financing. The fresh capital comes from Debioinvestment and Polytech Ventures, along with existing investors, and pushes Paper.li's total investment to about $7.2 million. The ambitious … Continue reading
Posted in Funding, Switzerland-Startups Tagged content curation, funding, Lausanne, paper.li, SmallRivers Comments Off
Short interview with Arnaud Bertrand (CEO, HouseTrip)
Last Thursday, Housetrip has announced a $17 million Series B funding round led by Balderton Capital. The Lausanne (Switzerland) based startup describes itself as Europe's leading holiday apartment website. Aside of Balderton Capital, the investor consortium of the current financing … Continue reading
Posted in Interviews, Switzerland-Startups Tagged Arnaud Bertrand, financing round, holiday rentals, HouseTrip, interview, Lausanne Comments Off
Fresh capital and a new design for HouseTrip
HouseTrip, the Lausanne based holiday rentals company, recently raised $2.7 million from Index Ventures. The second news about HouseTrip is the complete relaunch of their website wich happend today. The young company was founded in 2009 and its rental platform … Continue reading
Posted in Funding, Switzerland-Startups Tagged financing round, holiday rentals, HouseTrip, Index Ventures, Lausanne, Relaunch Comments Off
Paper.li now speaks seven languages
Paper.li, a Swiss startup that transforms individual Twitter-data into a readable newspaper, has just welcomed its 7th language this week - Portuguese. With the inclusion of the semantic analysis of content and its links for the Portuguese language, Paper.li extends its service to … Continue reading
Posted in Switzerland-Startups Tagged Lausanne, paper.li, Portuguese, semantic analysis Comments Off
Paper.li: From Facebook status updates to a Newspaper
Last month we already reported about this Swiss startup that transforms individual Twitter-data into a readable newspaper. paper.li now also added Facebook status updates to its armoury. Users now can create papers based on all posts on Facebook that are available for public. … Continue reading
Paper.li has just launched in German and French
Paper.li is a free service that turns twitter-feeds into an easy readable online-newspaper. In addition to the English version, the website has now launched in German and French. The next language that is going to follow will be Spanish. Paper.li was started by SmallRivers … Continue reading
Posted in Re-/Launch, Switzerland-Startups Tagged EPFL, Lausanne, paper.li, SmallRivers, Twitterstream Comments Off


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Reach tens of thousands of people instantly by advertising with Ekklesia. Find out more
The hanging of a paralysed Pakistani man, which had been expected to take place yesterday (22 September) has not gone ahead, after a magistrate issued a last-minute stay of execution.
The family of a paraplegic death row prisoner in Pakistan have begged the authorities to cancel plans to execute him on 22 September.
The Lahore High Court has ruled that a disabled death-row inmate can be hanged, in a judgment suggesting Pakistan's international obligations "should be kept aside."
The UK Government has refused to confirm whether UK pilots have been involved in flying covert US drone strikes over Pakistan.
A Pakistani court will decide today (8 September) whether the government should be allowed to execute a severely mentally ill man.
A court hearing in Pakistan tomorrow (31 August) could decide whether the government should be allowed to execute a severely disabled man.
A Government-appointed medical board in Pakistan has confirmed that a prisoner facing execution in the coming weeks has no use of his lower limbs and is "bed bound."
More than 16,000 of the most vulnerable people in flood-hit areas of India and Pakistan will get help following a grant of £158,000 to Christian Aid from the UK's Start Fund.
Amnesty International has called for Pakistan to impose a moratorium on the death penalty after the execution of a man who was a juvenile at the time of his crime.
Shafqat Hussain was executed in Pakistan this morning despite widespread calls both within and outside the country for a stay.


text:
Venturer tunic by Sarah Hatton
Welcome! You are browsing as a guestWould you like to see 3 projects made from this pattern and much more? join Ravelry now What am I missing?
© s.hatton 2012
Venturer tunic
Materials - 7 8:9:9:10 balls of Rowan Cocoon
For more information, see: http://www.sarahhatton.com


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Energy-efficient elementary up and running
Anne Rowe, left, of Danielsville gets a hug Thursday morning from Suzanne Hudgens during a tour of Madison County's new Hull-Sanford School. Madison County public school students begin classes today.
Rebecca Breyer/ Photo staff
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text: S'Arenada is a great option if you are looking for a small family run boutique hotel just outside of Villasimius. Superior rooms are spacious, nice and very clean. We had a lovely terrace overlooking the gardens and the hills. Breakfast was fresh and delicious. Alessandra made us feel at home from the very first moment (she actually called us when... More


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Welcome, skip to the content.
Official site for Melbourne, Victoria, Australia
Dates: 2 Feb 20152 Mar 20156 Apr 20154 May 20151 Jun 20156 Jul 20153 Aug 20157 Sep 20155 Oct 20152 Nov 2015
Address: Federation Square , 2 Swanston Street, Melbourne, Victoria 3000
Phone: 03 9655 1900
Email: firstname.lastname@example.com: fedsquare.com/events/classics-at-fed-square/
Enjoy your favourite music all year round with Classics at Fed Square.Held in the stunning surrounds of the Deakin Edge, these free monthly concerts offer something for everyone, from classical and swing to big band, jazz and even contemporary pop!The diverse program includes some of the best local soloists along with big bands from across Victoria. Bring a friend and make a day of it, with free exhibitions at ACMI and The Ian Potter Centre: NGV Australia and plenty of great cafes open for lunch or coffee.
Content: Federation Square
This is a free event.
Deakin Edge, Fed Square
Contact operator for further details.
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text:
Netanyahu is doing the right thing in trying to convince everybody around the world that Iranian nukes are a threat to world peace. And I doubt that other than Israel's enemies anybody has an argument against it. The problem with Netanyahu is that he also drops plenty of hints that Israel will attack Iran if their nuclear activity does not cease. The plain fact is that Israel cannot stop Iran by itself and its military means. It may be able to destroy a facility, but this will be quickly replaced, and Iranian efforts will only redouble. In the meantime, Israel will buy itself a dangerous enemy who will come up with some retaliation. The "cure" will be worse than the disease. Better promote sanctions and NATO action. The problem with Likud people is that they are unable to see the consequences of their actions. And talking a crazy talk might get Netanyahu to act crazily.
from the article: World powers urge Iran to accept standing nuclear offer


text:
Shannan Gilbert's Mother Sues Doctor, Claiming He Could Have Prevented Her Death
Her mother says he gave her drugs, but he says he never met her.By Margaret Hartmann
Her mother says he gave her drugs, but he says he never met her.By Margaret Hartmann
What hath Psy wrought?By Eliot Glazer
He wanted $2 million.By Joe Coscarelli
It's being investigated as a homicide.By Andre Tartar
What's the deal with all these gators?By Brett Smiley
Thankfully, the five kids on board were uninjured.By Margaret Hartmann
Propane tanks are likely to blame.By Adam K. Raymond
Eddie's Pizza in New Hyde Park is suing three other Italian restaurants for using the term "bar pie."By Jenny Miller
She's suing the police department over her torrid relationship with a cop.By Joe Coscarelli
The greens fee will be pretty expensive.By Brett Smiley
Their poor underprivileged children might have to endure summer without cookies-and-cream.By Jenny Miller
The weekend alcohol ban is upon them.By Joe Coscarelli
The day can only get better after that.By Joe Coscarelli
A drug ring was busted for selling to customers from out east.By Joe Coscarelli
Cops believe she may have drowned.By Andre Tartar
The police commissioner and the D.A. disagree.By Joe Coscarelli
Personally, we think schools should be encouraging any fad that doesn't involve putting vodka in your vagina.By Dan Amira
Police find items that belonged to Shannan Gilbert, whose disappearance led to the discovery of ten bodies near a desolate beach.By Robert Kolker
True story: Patric-ha was waiting on our friend at a diner on Long Island, when she broke out into a seven-minute-long stand-up routine.By Eliot Glazer
He was only trying to defend the good name of Long Island.By Dan Amira


text:
Candids of Mischa's second trip to Warren-Tricomi salon have been added. This time she's getting hair extensions put back in.
Candids of Mischa's second trip to Warren-Tricomi salon have been added. This time she's getting hair extensions put back in.
Photos of Mischa looking absolutely INCREDIBLE at the Beverly Hills Fashion Festival have been added.
And now with these event photographs we can better see her new hair. The blonde is a much more natural shade and the extensions are definitely gone. She looks beautiful!!!!
A photo of Mischa at the Maroon 5 Halloween Bash presented by Bacardi has been added.
Photos of Mischa at the yoox.com And DSQUARED2 Canine Couture Launch have been added. She looks great!!
Photos of Mischa at the Simply Stylist Caro Marketing event held in West Hollywood have been added. I think she looks great!
Photos of Mischa at the 1st Annual Veuve Clicquot Polo Classic held in Los Angeles have been added. I think it would have been a more successful look if Mischa's hair was a natural shade.
ETA: Also added some candids from the same event.
Photos of Mischa at a private party at Le Cointreau Prive in Paris – a members only bar opened by Dita Von Teese – have been added to the gallery. I really love the way Mischa looks in these pics! Very cool.
Photos of Mischa at the Salvatore Ferragamo Seize the Moment Party have been uploaded. This again is an event part of Milan Fashion Week.
I love love love love when Mischa attends any fashion week. It always means an array of photos! 😀
Photos of Mischa at the Glamour Party in honour of Diane Von Furstenberg held during Milan Fashion Week S/S 2011 have been added. DJ Ali features so it looks like these two are still together.
Mischa attended a couple of events for Philipp Plein during his new season show at Milan Fashion Week:
– Philipp Plein 2011 Milan Fashion Week
– Philipp Plein 2011 Milan Fashion Week After Party