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Fame is the name of the game
Why are today's celebrities so disposable? Julie Burchill finds that in a fame game that celebrates ambition before talent, the stars are destined to fade fast.
Weekend comment & features p7
Words that should be banned
In terms of international conflict, this is quite a handy word; a comparatively unloaded middleman between 'freedom fighter' and 'terrorist'. But nobody uses it like that, presumably because nobody feels comfortable describing rebels without telling us if they're goodies or baddies. Instead, we have Rebel MPs, Rebel Royals and - this is the one that makes me gag - Young Rebels.
Weekend comment & features p9
How to... prevent choking
Choking is like being strangled from the inside. It's no laughing matter, even though it can sound very much like a laughing matter to begin with. If you're prone to this kind of thing, it's best to steer well clear of jewellery, especially chokers, choke chains, throttlers, etc.
Features & comment p10
Under siege
Britain has a poor record for its treatment of Muslims. Since September 11, Angelique Chrisafis reports, women wearing veils have been the target of violence and abuse.
Weekend comment & features p22
It's wild out there
Hyenas, aardvarks, camels... natural historians may seek to convince us about the beauty of the animal world, but who on earth could have dreamt up such absurd looking beasts? Guy Browning casts a critical eye.
Weekend comment & features p34
Precious plunder
Law suits demanding restitution of art looted by the Nazis may force some of the world's leading galleries to hand back some of their most treasured possessions. Ian Traynor meets the Russian who has taken his case to the western courts
Weekend comment & features p56
How to wear clothes
Dress up or dress down? Jess Cartner-Morley helps you safely through the minefield that is the office Christmas party.
Weekend comment & features p69
We love each other
Cory We had only known each other two and a half to three months. And then one night, after she had just worked a double shift for me, which was incredibly good of her, I said, 'Okay, as thanks, you can have whatever you want.' I was expecting, you know, a dinner or a free drink. She said, 'I want you to marry me.' So I said back to her, 'Is that all?'
Weekend comment & features p84
Life in the slow lane
Tortoises may be high-maintenance pets, but they can bring years of joy (up to 80 years, in fact) for those who have committed to one. John Cornelius pays tribute to his very own 'clockwork meat pie'.
Weekend comment & features p86
To DIY for
Bleeding radiators isn't real plumbing. It's like letting the wind out of a mechanical cow. Just as a cow's four stomachs lead to its prodigious gas output, your central heating can get air trapped, too. Water expands when heated, so every time your boiler comes on, the radiators' water takes up more room than it did a minute ago (that's why you have an expansion tank in the loft for it to expand into). When it contracts again, it can suck in air. Air also gets in through small leaks (surprisingly common, particularly around radiator valves ) during expansion and contraction. A classic symptom of trapped air is if your radiators don't get warm at the top. You may also hear ruminant-style gurglings. Get a radiator key. Locate the bleed nipple, or valve shank, usually on a top corner of the radiator, and try your key . Now go back and buy one the right size (they're not standardised). Standing by with an old mug for catching water and an old towel just in case, slot in your key. Turn it a quarter of a turn anticlockwise; no more or you'll get covered in brown stuff. Leave the air leak to flow out (this may take some time) until a spit of water begins, then shut it off. Top tip: Dale Courtman, Britain's Top Plumber, says the experts then give it another quick quarter turn. That's £50 you've saved. If you need to bleed your radiators more than once every year or two you could have Expansion Tank Valve Grief, which should be addressed sooner rather than later, because air in the system means rust. Rust is cholesterol for central heating, and you don't want the old girl to get that, as it can lead to major central heating surgery.
To die for
You really wouldn't want to be a trend predictor in these uncertain times. Oh God, no. Can you imagine, all the work that has gone to waste? Just when you have decided, well decreed really, that the key to style in 2003 would be "roundness", the world changes. A million trend reports have to be entirely rethought and rewritten. Pure hell. But there is a way out: to contradict yourself totally. "Sometimes when the outside world is hard and aggressive, we need to build an interior where we feel soft and sexual," said one of Europe's most influential trend analysts at a recent forum. "So where we had roundness, we needed new shapes, with new edges." So there you have it, the rudiments of what I, quite honestly, would call the science of trend prediction: blurriness.
Features & comment p89
All that jazz
Some collectors are terribly precious about the things they hoard, and file them away in dusty cabinets. But not Bob Borzello. He makes use of his art-deco treasures every day, says Caroline Roux.
Weekend comment & features p90
Let's move to...
Unlike everywhere else, the Isle of Man actually wants people to move in. The right sort, of course. It wants high skills for its offshore finance industry and, being a fairly conservative sort of place (homosexuality was illegal until 1992; the death penalty legal until 1993), it's probably not after people with an excessive love of anarchy/Marilyn Manson/the Guardian, etc.
Features & comment p101
The expert gardener
Planting spring bedding in early autumn is common practice, the main reasons being that the summer bedding looked awful and there was a great urge for a new look, coupled with the fact that the retail salesmen have the plants ready, being keen to get them off their hands as early as possible.
Features & comment p105
The proof of the pudding...
There are few things that can be done to improve the taste of a ripe pineapple, says Heston Blumenthal. But roasting the fruit is one of them.
Features & comment p106
QC, London WC1
Telephone: 020-7829 2000
Address: Renaissance London Chancery Court, 252 High Holborn, London WC1
Weekend comment & features p110
Super plonk
Malcolm Gluck agrees that Majestic's insistence on flogging wine only by the case or mixed case is a pain, but nonetheless finds plenty to applaude in their ranges of both red and white.


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Lately, we've been seeing neon everywhere. We can't help but add a little splash to our everyday ensemble, but what about neon in weddings? By itself, neon makes a soiree casual, but mixing it with neutrals creates a chic celebration. Just like you're nosy, soon-to-be mother-in-law, we think neon is great in small doses.
Below are a few of our favorite ways to do neon at your wedding!
(The Fabulous Life of a Pinto Bean; Kelly Hornberger; 57 Grand)

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President's Lecture Series on Leadership and Diversity, featuring Univers...
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Crazy Love: A Night With Leslie Morgan Steiner
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Clemson Tigers are fierce and passionate competitors. From the stadium to the classroom to the research lab, Tigers play to win. Our academic programs are rigorous and challenging, but that's what makes a Clemson degree so valuable. We're ranked first in the state for value and return on investment. And Clemson is currently ranked No. 21 among all public universities in the U.S.News & World Report. Clearly, Clemson's teaching, research and outreach are driving development and improving the quality of life in South Carolina and far beyond. Clemson graduates are equipped with the skills, adaptability and top-quality education to take on whatever challenges they encounter. Go Tigers!
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Welcome to WebmasterWorld Guest from 220.127.116.11
Forum Moderators: bill
Wouldn't it be great if the glory days lasted forever? But reality is trophies get dusty, records are broken, and what it took to be the best ten years ago, just isn't enough for today's standards. Things get better, faster. And eventually, it's time to move from good enough to something much better.
Windows XP had an amazing run and millions of PC users are grateful for it. But it's time to move on. Two reasons: 1) Extended support for Windows XP is running out in less than 1000 days, and 2) there's an OS out there that's much better than Windows XP.
On April 8, 2014, security patches and hotfixes for all versions of Windows XP will no longer be available. So bottom line, PC's running Windows XP will be vulnerable to security threats. Furthermore, many third party software providers are not planning to extend support for their applications running on Windows XP, which translates to even more complexity, security risks, and ultimately, added management costs for your IT department if you're still managing Windows XP environments.


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|Publication number
|Publication type
|Application number
|Publication date
|Dec 28, 1999
|Filing date
|Dec 2, 1997
|Priority date
|Dec 2, 1997
|Fee status
|Also published as
|Publication number
|Catherine Ting Lee, Jun Yang, Tan Thanh Dinh, Ernest H. Pfadenhauer
|Original Assignee
|Baxter International Inc.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (11), Non-Patent Citations (4), Referenced by (25), Classifications (20), Legal Events (5)
|External Links: USPTO, USPTO Assignment, Espacenet
The invention pertains generally to medical method/devices and more particularly to a method for chemically modifying glutaraldehyde-fixed bioprosthetic materials to mitigate their propensity for post-implantation calcification.
In modern medical practice, numerous implantable devices or prostheses are formed wholly or partially of biological tissue which has been chemically "fixed" or preserved. The technique used for chemical fixation of biological tissues typically requires exposure of the biological tissue to one or more chemical agents which are capable of forming cross-linkages between connective tissue protein molecules present in the tissue.
Examples of fixed biological tissues which have been used as bioprostheses include cardiac valves, blood vessels, skin, dura mater, pericardium, ligaments and tendons. These tissues typically contain a matrix of connective tissue proteins which act as the supportive framework of the tissue.
Collagen and elastin are two connective tissue proteins which make up the connective tissue framework of most biological tissues. The pliability or rigidity of each biological tissue is largely determined by its relative amounts of collagen and elastin and/or by the physical structure and confirmation of its connective tissue frame work.
Each collagen molecule is made up of three (3) polypeptide chains intertwined in a coiled helical confirmation. The chemical fixatives (i.e., tanning agents) which are used to preserve biological tissues generally form chemical cross-linkages between the polypeptide chains within a given collagen molecule (i.e., intramolecular crosslinkages), or between adjacent collagen molecules (i.e., intermolecular crosslinkages).
Examples of chemical fixative agents which have been utilized to crosslink collagenous biological tissues include; formaldehyde, glutaraldehyde, dialdehyde starch, hexamethylene diisocyanate and certain polyepoxy compounds. Of the various chemical fixatives available, glutaraldehyde is the most widely used. Glutaraldehyde is used as the fixative for many commercially available bioprosthetic products, such as porcine bioprosthetic heart valves (i.e., the Carpentier-Edwards� stented porcine bioprosthesis; Baxter Healthcare Corporation; Edwards CVS Division, Irvine, Calif. 92714-5686), bovine pericardial heart valve prostheses (e.g., Carpentier-Edwards� Pericardial Bioprosthesis, Baxter Healthcare Corporation, Edwards CVS Division; Irvine, Calif. 92714-5686) and stentless porcine aortic prostheses (e.g., Edwards� PRIMA™ Stentless Aortic Bioprosthesis, Baxter Edwards AG, Spierstrasse 5, GH6048, Horn, Switzerland).
One problem associated with the implantation of bioprosthetic materials is that the connective tissue proteins within these materials tend to undergo calcification. Such calcification can result in undesirable stiffening or degradation of the bioprosthesis. Both intrinsic and extrinsic calcification are known to occur in fixed collagenous bioprostheses, although the exact mechanism(s) by which such calcification occurs is unknown.
Clinical experience and experimental data has taught that glutaraldehyde-fixed collagenous bioprostheses may tend to calcify sooner than bioprostheses which have been fixed by other nonaldehyde fixative agents. Such accelerated calcification of glutaraldehyde-fixed bioprostheses has been reported to predominantly occur in pediatric patients. (Carpentier et al., Continuing Improvements in Valvular Bioprostheses, J. Thoracic Cardiovasc. Surg. 83:27-42, 1982.) Such accelerated calcification is undesirable in that it may lead to deterioration and/or failure of the implanted bioprostheses. In view of this propensity for accelerated calcification of glutaraldehyde-fixed bioprostheses in young patients, surgeons typically opt to implant mechanical heart valves or homografts (if available) into pediatric or relatively young patients (i.e., patients under 65 years of age), rather than glutaraldehyde-fixed bioprosthetic valves. However, patients who receive mechanical valve implants require ongoing treatment with anticoagulant medications, which can be associated with increased risk of hemorrhage. Also, homografts are of limited availability and may carry pathogens which can result in infection.
The factors which determine the rate at which glutaraldehyde-fixed bioprosthetic grafts undergo calcification have not been fully elucidated. However, factors which are thought to influence the rate of calcification include:
a) patient's age;
b) existing metabolic disorders (i.e., hypercalcemia, diabetes, etc.);
c) dietary factors;
d) race;
e) infection;
f) parenteral calcium administration;
g) dehydration;
h) distortion/mechanical factors;
i) inadequate coagulation therapy during initial period following surgical implantation; and
j) host tissue responses.
Many investigators have attempted to discover ways of mitigating the in situ calcification of glutaraldehyde-fixed bioprostheses. Included among these calcification mitigating techniques are the methods described in U.S. Pat. No. 4,885,005 (Nashef et al.) entitled Surfactant Treatment of Implantable Biological Tissue To Inhibit Calcification; U.S. Pat. No. 4,648,881 (Carpentier et al.) entitled Implantable Biological Tissue and Process For Preparation Thereof; U.S. Pat. No. 4,976,733 (Girardot) entitled Prevention of Prosthesis Calcification; U.S. Pat. No. 4,120,649 (Schechter) entitled Transplants; U.S. Pat. No. 5,002,2566 (Carpentier) entitled Calcification Mitigation of Bioprosthetic Implants; EP 103947A2 (Pollock et al.) entitled Method For Inhibiting Mineralization of Natural Tissue During Implantation and WO84/01879 (Nashef et al.) entitled Surfactant Treatment of Implantable Biological Tissue to Inhibit Calcification; and, in Yi, D., Liu, W., Yang, J., Wang, B., Dong, G., and Tan, H.; Study of Calcification Mechanism and Anti-calcification On Cardiac Bioprostheses Pgs. 17-22, Proceedings of Chinese Tissue Valve Conference, Beijing, China, June 1995.
Because none of the previously known calcification mitigation, technique has proven to be optimal for glutaraldehyde-fixed tissues. There exists a need in the art for the development of new methods for inhibiting or mitigating calcification of glutaraldehyde-fixed biological tissues.
Broadly stated, the present invention provides methods for improving the biocompatability and/or performance of glutaraldehyde-fixed biological tissue by treating the tissue with a polyglycidyl ether concurrently with or following the glutaraldehyde fixation.
In many applications, the method of the present invention will be carried out by the following steps:
a. preparing a biological tissue which contains connective tissue proteins;
b. contacting the biological tissue with an aldehyde fixative (e.g., formaldehyde or glutaraldehyde) to effect crosslinking of the connective tissue proteins within the tissue; and
c. concurrently with, or after, the completion of step (b), contacting the tissue with a polyglycidyl ether.
In accordance with the above-summarized method of the present invention, steps b and c may be carried out using separate aldehyde and polyglycidyl ether solutions--or by using an aldehyde/polyglycidyl admixture. For example, the tissue may be initially contacted with the aldehyde to carry out step b completion and thereafter the tissue may be removed from the aldehyde fixative and subsequently contacted with the polyglycidyl ether. Alternatively, the tissue be initially contacted with the aldehyde for an initial period of time to permit partial or complete crosslinking of the connective tissue protein(s) and, thereafter, the polyglycidyl ether(s) may be added to the aldehyde--to form a polyglycedyl ether/aldehyde admixture in the presence of the fully or partially crosslinked tissue. Alternatively, a polyglycidyl ether/aldehyde admixture may be initially prepared and the fresh tissue may then be contacted with such admixture to carry out steps b (cross-linking) and c (post-crosslinking ether treatment) using a single admixture.
Further in accordance with the present invention, there are provided various types of bioprosthetic articles which are wholly or partially formed of tissue which has been prepared by the above-summarized method of the present invention. Examples of the types of biological tissues which may be utilized to prepare bioprosthetic articles in accordance with this invention include, but are not necessarily limited to: heart valves, venous valves; blood vessel; ureter; tendon; dura mater; skin; pericardium; cartilage (e.g., meniscus); ligament; bone; intestine (e.g., intestinal wall); and periostium.
Further aspects and objects of the present invention will become apparent to those skilled in the relevant art, upon reading and understanding the detailed description of presently preferred embodiments set forth below.
The following detailed description and the accompanying drawing to which it refers are provided for purpose of describing and illustrated presently preferred embodiments of the invention only, and are not intended to limit the scope of the invention in any way.
With reference of the flow diagram of FIG. 1, a presently preferred method for preparing a fixed biological material in accordance with the present invention comprises the steps of:
(a) preparing a biological tissue which contains connective tissue proteins;
(b) contacting the biological tissue with an aldehyde fixative, such as glutaraldehyde, to effect crosslinking of the connective tissue proteins within the tissue; and
(c) concurrently with or after the completion of step (b), contacting the tissue with a polyglycidyl ether.
In performing this method of the present invention, steps b and c may be carried out using separate aldehyde and polyglycidyl ether solutions--or by using an aldehyde/polyglycidyl admixture. For example, the tissue may be initially contacted with the aldehyde to carry out step b completion and thereafter the tissue may be removed from the aldehyde fixative and subsequently contacted with the polyglycidyl ether. Alternatively, the tissue be initially contacted with the aldehyde for an initial period of time to permit partial or complete crosslinking of the connective tissue protein(s) and, thereafter, the polyglycidyl ether(s) may be added to the aldehyde--to form a polyglycidyl ether/aldehyde admixture in the presence of the fully or partially crosslinked tissue. Alternatively, a polyglycidyl ether/aldehyde admixture may be initially prepared and the fresh tissue may then be contacted with such admixture to carry out steps b (cross-linking) and c (post-crosslinking ether treatment) using a single admixture.
The preferred fixative solution for step b of the method is 0.625% glutaraldehyde buffered to a pH of approximately 7.4 by a suitable buffer such as a phosphate buffer.
The preferred polyglycidyl ethers for step c of the method are ethylene glycol diglycidyl ether (Denacol EX810, Nagese Chemical Co., Osaka, Japan) and glycerol polyglycidyl ether (Denacol EX313, Nagese Chemical Co., Osaka, Japan). Step c may be carried out by immersing the tissue in a solution containing between 1 and 10 percent by volume of the polyglycidyl ether. Additionally, the polyglycidyl ether solution used in Step c may contain one or more alcohol(s), such as ethanol, preferably at an ethanol concentration of approximately 10-30 percent by volume.
PROCEDURE: Bovine pericardial tissue is fixed with glutaraldehyde by a 14 day treatment with a 0.625% solution in pH 7.4 phosphate buffer. After washing three times in water, the tissue is treated with a solution of 2% Denacol EX-810 and 20% ethanol in water for 120 hours at 43-46� C. As a control, glutaraldehyde fixed tissue is treated with the sterilizing solution of Glutaraldehyde (0.625% in pH 7.4 phosphate), ethanol (20%) and Tween 80 (0.2%) for 24-28 hours at 43-46� C. Tissues are stored in the final solution at room temperatures until use.
Calcification potential is measured by exposing the tissue to solutions of:
(1) Calcium Chloride (2.5 mM in pH 7.0 Tricine buffer) or
(2) Human Serum
For each condition, 3�1 cm2 pieces of fixed tissue are added to 50 ml of treatment solution and incubated at 37� C. in an orbital shaker for three weeks. One piece of tissue is removed every week for elemental analysis. The tissue is washed 4 times with water for 40 minutes each time, lyophilized, weighed, then digested with 4 ml of 70% nitric acid at 100� C. Samples are then analyzed for elemental Calcium.
RESULTS: Calcium content, expressed at % of total weight of the tissue, is summarized in the table below.
______________________________________ 1 week 2 weeks 3 weeks Condition (Ca %) (Ca %) (Ca %)______________________________________Ca2 Cl Control 0.18% 0.15 0.22 Denacol EX 0.02% 0.08 0.06 810 serum control 0.01 0.44 1.26 Denacol EX 0.00 0.11 0.62 810______________________________________
This experiment demonstrates that ethylene glycol diglycidyl ethers have the ability to mitigate tissue calcification after glutaraldehyde fixation.
One possible mechanism by which the polyglycidyl ether treatment serves to mitigate calcification of glutaraldehyde fixed tissue may be through a direct reaction between the glutaraldehyde crosslinkages (or free glutaraldehyde which remains present in the tissue) and the polyglycidyl ether.
PROCEDURE: Solutions of both 4% ethylene glycol diglycidyl ether (Denacol EX 810) and 4% glycerol polyglycidyl ether (Denacol EX 313) are mixed with 0.625% glutaraldehyde in an aqueous solution buffered with phosphate to pH 7.4. The reaction is allowed to proceed at room temperature for 7 days. The reaction mixture, along with controls of each component alone or in buffer, and freshly made controls of each component, are analyzed by ultraviolet (UV)-Visible spectroscopy and reactivity to N-a-acetyl-lysine on days 1, 2, 3 and 7, and thin layer chromatography on day 7.
RESULT: UV spectra of the reaction solution shows changes over time at 235 nm. This wavelength has previously been shown to be characteristic of a homopolymer of glutaraldehyde, but in this case is probably due to the formation of a copolymer of polyglycidyl ether and glutaraldehyde. The table below shows the 235 nm absorbence from day 0 to day 7. Dilutions are made where necessary to bring absorbence readings within the spectrometer dynamic range.
______________________________________Absorbence at 235 nm Solution Day 0 Day 1 Day 2 Day 3 Day 7______________________________________GA 2.1 2.4 2.7 2.9 3.0 EX313 0.37 0.32 0.35 0.35 0.32 EX810 0.12 0.16 0.17 0.17 0.16 GA + EX313 2.5 13.6 17.2 21.0 24.8 GA + EX810 2.3 15.6 18.3 22.0 25.3______________________________________
Reactivity of glutaraldehyde is measured by its ability to form a complex with N-a-acetyl-lysine, which has a strong absorption at 265 nm. At each time point, an aliquot of each solution is removed, diluted 1:10, and 1.0 ml added to 0.5 ml of 15 mM N-a-acetyl-lysine in pH 7.4 phosphate buffer. After 45 min., the reaction is further diluted 4:1, and read at 265 nm. Reactivity is compared to equally aged glutaraldehyde mixed with freshly made Denacol. The table below shows the % glutaraldehyde reactivity lost, as measured by a decrease in 265 absorbence, relative to that of a fresh Denacol solution.
______________________________________% Activity Lost Solution Day 1 Day 2 Day 3 Day 7______________________________________GA + EX313 23 44 50 66 GA + EX810 41 54 61 75______________________________________
Reaction products are detected by a thin-layer chromatography (TLC) system, consisting of Whatman K6 silica plates developed with chloroform:methanol (95:5). Visualization was accomplished by exposure to Iodine vapor. Glutaraldehyde and Denacol each show characteristic components after visualization, however the reaction mix at 7 days shows a dark residue at the origin, indicating a new reaction product and consistent with copolymer formation.
The invention has been described above with reference to certain presently preferred embodiments or examples only and no attempt has been made to exhaustively describe all possible embodiments or examples of the invention. Those skilled in the art will recognize that various modifications, additions and changes may be made to the particular embodiments and examples described above without departing from the intended spirit and scope of the invention. Accordingly, it is intended that all such modifications, additions and changes be included within the scope of the following claims.
|Cited Patent
|Filing date
|Publication date
|Mar 29, 1976
|Oct 17, 1978
|Israel Schechter
|Aug 25, 1982
|Sep 20, 1983
|Extracorporeal Medical Specialties, Inc.
|Method for inhibiting mineralization of natural tissue during implantation
|Nov 29, 1982
|Mar 10, 1987
|American Hospital Supply Corporation
|Implantable biological tissue and process for preparation thereof
|Feb 27, 1987
|Dec 5, 1989
|Baxter International Inc.
|Surfactant treatment of implantable biological tissue to inhibit calcification
|Jan 27, 1989
|Dec 11, 1990
|Biomedical Design, Inc.
|Prevention of prosthesis calcification
|Apr 18, 1989
|Mar 26, 1991
|Baxter International Inc.
|Calcification mitigation of bioprosthetic implants
|Sep 2, 1994
|Aug 27, 1996
|Baxter International Inc.
|Natural tissue valve prostheses having variably complaint leaflets
|Aug 30, 1988
|Mar 8, 1989
|Koken Co. Ltd.
|Bioprosthetic valve
|Feb 13, 1992
|Sep 3, 1992
|Baxter Int
|Pliable biological graft materials and their methods of manufacture
|Jan 28, 1994
|Aug 18, 1994
|Baxter Int
|Biological grafts having regionalized differences in cross-link density and their methods of manufacture
|Oct 20, 1995
|May 9, 1996
|Univ Michigan
|Calcification-resistant bioprosthetic tissue and methods of making same
|Chachra et al., "Effect of Applied Uniaxial Stress on Rate and Mechanical Effects of Cross-Linking in Tissue-Derived Biomaterials, " Biomaterialsvol. 17, Oct 1996, 1865-1875.
|Chachra et al., Effect of Applied Uniaxial Stress on Rate and Mechanical Effects of Cross Linking in Tissue Derived Biomaterials, Biomaterials vol. 17, Oct 1996, 1865 1875.
|Zhou et al., "Porcine Aortic Wall Flexibility Fresh vs Denacol Fixed vs Glutaraldehyde Fixed," ASIAO Journal, vol. 43, No. 5, 470-475, Sep 1997, Edwards CVS Division, Baxter Healthcare Corporation.
|Zhou et al., Porcine Aortic Wall Flexibility Fresh vs Denacol Fixed vs Glutaraldehyde Fixed, ASIAO Journal, vol. 43, No. 5, 470 475, Sep 1997, Edwards CVS Division, Baxter Healthcare Corporation.
|Citing Patent
|Filing date
|Publication date
|Apr 6, 2001
|Apr 15, 2003
|Edwards Lifesciences Corporation
|Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby
|Feb 5, 2003
|Apr 18, 2006
|Edwards Lifesciences Corporation
|Methods for treating implantable biological tissues to mitigate post—implantation calcification
|Dec 18, 2006
|Nov 17, 2009
|Grandhope Biotech Co. Ltd.
|Biological artificial nerve guide and method of making
|Jul 28, 2006
|Mar 9, 2010
|Grandhope Biotech Co., Ltd.
|Biological artificial ligament and method of making
|Dec 15, 2006
|Oct 26, 2010
|Grandhope Biotech Co., Ltd.
|Biological wound dressing and method of making
|Feb 3, 2010
|Nov 2, 2010
|Grandhope Biotech Co. Ltd.
|Biological artificial ligament and method of making
|May 11, 2010
|Jul 5, 2011
|Edwards Lifesciences Corporation
|Capping bioprosthetic tissue to reduce calcification
|Oct 23, 2007
|Aug 30, 2011
|Edwards Lifesciences Corporation
|Method of treating glutaraldehyde-fixed pericardial tissue with a non-aqueous mixture of glycerol and a C1-C3 alcohol
|Dec 15, 2006
|Jan 24, 2012
|Grandhope Biotech Co., Ltd.
|Biological surgical patch and method of making
|Apr 29, 2011
|Mar 20, 2012
|Kemal Schankereli
|Thin collagen tissue for medical device applications
|Aug 1, 2006
|Jun 12, 2012
|Grandhope Biotech Co., Ltd.
|Biological membrane-carrying aneurysm clip
|May 4, 2007
|Aug 7, 2012
|Edwards Lifesciences Corporation
|Treating biological tissues to mitigate post-implantation calcification
|Jul 28, 2006
|Oct 23, 2012
|Grandhope Biotech Co., Ltd.
|Biological artificial blood vessel and method of making
|Dec 18, 2008
|Jan 22, 2013
|Edwards Lifesciences Corporation
|Capping bioprosthetic tissue to reduce calcification
|Nov 10, 2009
|Feb 5, 2013
|Grandhope Biotech Co. Ltd.
|Biological artificial nerve guide and method of making
|Jan 17, 2012
|Jan 21, 2014
|Edwards Lifesciences Corporation
|Treatment of bioprosthetic tissues to mitigate post implantation calcification
|Jan 18, 2013
|Jun 10, 2014
|Edwards Lifesciences Corporation
|Capping bioprosthetic tissue to reduce calcification
|Mar 23, 2011
|Sep 30, 2014
|Edwards Lifesciences Corporation
|Methods of conditioning sheet bioprosthetic tissue
|Jun 28, 2002
|Nov 4, 2014
|Cook Biotech Incorporated
|Porous sponge matrix medical devices and methods
|Jun 17, 2011
|Dec 9, 2014
|Edwardss Lifesciences Corporation
|Methods for stabilizing a bioprosthetic tissue by chemical modification of antigenic carbohydrates
|Dec 23, 2013
|May 12, 2015
|Edwards Lifesciences Corporation
|Capping bioprosthetic tissue to reduce calcification
|Jun 9, 2008
|Aug 11, 2015
|Edwards Lifesciences Corporation
|Methods for pre-stressing and capping bioprosthetic tissue
|Oct 5, 2004
|Apr 14, 2005
|Cunanan Crystal M.
|Treatment of tissue, instruments and work surfaces to remove infectious agents
|Nov 1, 2001
|Jun 6, 2002
|Edwards Lifesciences Corp
|Methods for preparation of bioprosthetic tissue and implantable devices comprising such bioprosthetic tissue
|Oct 13, 2010
|May 5, 2011
|Olivier Schussler
|Method for producing implantable medical bioprostheses having reduced calcification properties
|U.S. Classification
|525/54.1, 623/23.76, 8/94.11
|International Classification
|Cooperative Classification
|European Classification
|May 21, 1998
Owner name: BAXTER INTERNATIONAL INC., ILLINOIS
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|Jun 9, 2000
|Jun 30, 2003
|Fee payment
Year of fee payment: 4
|Jun 28, 2007
|Fee payment
Year of fee payment: 8
|Jun 28, 2011
|Fee payment
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IiNet Plans to Split AAPT in Takeover Proposal, Australian Says
July 29 (Bloomberg) -- Iinet Ltd. has submitted a proposal to split the retail and wholesale arms of AAPT, the Australian unit of Telecom Corp. of New Zealand Ltd., and is seeking to buy its consumer business, the Australian newspaper reported, citing unidentified sources close to the sale. Telecom NZ is considering splitting the business and selling the wholesale division into the National Broadband Network after TPG Telecom Ltd.'s bid for all of AAPT failed to win approval, according to the report.
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P1 Roll Call: Tactical intervention; Off-duty cop electrocuted
This week, Dave Smith analyzes the reaction a Nebraska cop has when a civilian gives him a hard time and the "tactical intervention" approach another cop employs, the death of two officers that occurred in the past week, and a heroic "Not Today" moment from the LAPD.
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PoliceOne top 5
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The Kentwood Conquerors girls basketball team won Thursday's away conference game against Jefferson by a score of 48-41.
(December 8, 2011: Auburn, WA 98001) Fans at Thursday's league challenge between the Kentwood Conquerors (Covington, WA) and the host Jefferson Raiders (Auburn, WA), saw Kentwood's basketball squad hold off Jefferson by a score of 48-41.
The Conquerors (3-0) will now prepare for their test against Kent-Meridian (Kent, WA). The Royals go into the 4A SPSL - North test with a 1-3 record. In their last test, Kent-Meridian was tipped by Kentridge (Kent, WA), 57-43, in a league test.
The Raiders now own a 2-3 record. They take the field next when they host Tahoma for a 4A SPSL - North test on Saturday, December 10. Jefferson will clash with a Bears squad coming off a 69-28 league loss to Mt. Rainier (Des Moines, WA). The Bears record now stands at 1-2.


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The Marsh San Francisco MainStage Theater1062 Valencia St. San Francisco CA 94110 Three blocks from 24th & Mission BART
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Diamond Foxxx rides the Monkey Rocker and WOW does she know how to ride that thing just watch as that stiff cock slide in and out.
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Saint Ignatius of Santhiá was born on 5 June 1686 in Santhiá, in the Vercelli region of Northern Italy and died in Turin on 21 September 1770. He was a Capuchin priest, who was faithful to the Franciscan spirit, especially by his obedience, simplicity and humility. He was renowned for his gift of spiritual direction and concern for the spiritual growth of the faithful. He was also called the "father of sinners and the lost" thanks to his particular ability to deal with the "spiritually sick".
Capuchin vocation
He was baptized Lorenzo Maurizio, the fourth of six children of the upper-class Belvisotti family. He received his early education from a good priest, who inspired him and helped discern his call to enter the priesthood. In 1710 he was ordained a diocesan priest. After six years of priestly ministry, he joined the Capuchin Friars. At the time he suffered from the criticism of his family and parish who did not understand his decision. In the Capuchin Order Ignatius finally found the inner peace he had been searching for in the simplicity of Franciscan life.
Life of obedience
On 24 May 1717, he made his religious profession, and from that day he was like putty in the hands of his superiors. He began his spiritual journey being sent from one house to another in the Savoy region of Northern Italy. He was happy to be moved around out of obedience and honoured to be able to serve his brothers. He was completely at "God's disposition".
In 1727, Ignatius was sent to the convent in Torino-Monte, with the responsibility of prefect of the sacristy and confessor for the laity, a mission he was to fulfill for the last 24 years of his life when he returned to Turin after serving as master of novices and chief of chaplains for the army of the Kingdom of Savoy. In this ministry he showed his fatherly concern for others and the spiritual wisdom that is learned at the foot of the Crucified One. It was not long before religious, priests, the faithful and the most hardened sinners began coming to the monastery to make their confession and to receive spiritual direction.
Special forms of service
In 1731, he was sent to the monastery of Mondově, where he was made master of novices and vicar of the monastery. He was in charge of the novitiate for 14 years and his only desire was to make the novices entrusted to his care true followers of Christ and obedient sons of St Francis. His teaching was founded on two pillars: divinely loving the novices and teaching by example more than by words. He was available at all hours of the day and night for novices in need of help and he knew each one of them, making their formation his top priority. In 1744 he had to leave the novitiate and go to Turin because he suffered from a mysterious eye ailment that led to near blindness. He was partially cured so that he could return to active ministry.
In 1743-1746, war broke out in the Piedmont. This also brought with it the influx of the wounded and an epidemic. The King of Sardinia-Piedmont, Charles Emmanuel III asked the Capuchins to provide medical and spiritual care for the hospitals. Fr Ignatius was made head chaplain and offered his assistance for two years in the hospitals of Asti, Vinovo and Alessandria, offering an example of tireless activity and piety, serving and healing in a spirit of genuine evangelical love.
Spiritual director
When Piedmont was at peace, he returned once more to his convent in Turin-Monte where he would remain for 24 years as spiritual director and confessor. He visited the sick and begged for money and food for the needy. He died in Turin-Monte on 21 September 1770. He would often say: "Paradise is not made for slackers. Let's get to work!". To all people, religious brothers and laity, he taught the way of holiness and of abandonment in God's hands, by his example and by his words.
On 17 April 1966, Paul VI beatified Ignatius of Santhiá.
Biography Provided by: The Vatican
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Creative Fusion31 Chambers StreetSG14 1PL Hertford01992 892003Closed
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December 29, 2011
Skinny chicks do have the most beautiful pussies.
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Pretty blonde amateur girls strips for the camera and has a lot of fun with her toys.
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Skinny chicks do have the most beautiful pussies.
this girl is hot.got me hard and cumming in no time
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Wednesday, May 7, 2008
© Copyright 2015 Gwinnett Daily Post
DULUTH - Gwinnett County holds a lot of young, enthusiastic talent within its boundaries and Chamber officials want to keep it here.Hype, a networking organization for young professionals created by Partnership Gwinnett and the Gwinnett Chamber, will launch its first event at 5:30 p.m. today at Encore night club. The organization grew as a result of a nine-month study done by Partnership Gwinnett in 2006 that identified the need to market Gwinnett County as an attractive place for young professional workers to live, work and play, said Lisa Sherman, the Chamber's external marketing manager for economic development. "We want to retain young talent in the area for businesses," she said. "This is an organization where they can get opportunities for career development, community involvement and social networking." The organization was advertised on Facebook to reach those people. "Within one week, 75 people had signed on," Sherman said, adding that Hype has received 100 RSVPs to the event. Abby Wilkerson, director of public relations at redpepper and a member of Hype's steering committee, likens the event to a mini-chamber of commerce where everyone is at the same place in life. "You don't have to go to Midtown to find fun places to go and to find each other," Wilkerson said. "Partnership Gwinnett is working to retain new businesses and talent, not let them slip away. We are cultivating a succession plan, we are the next group of leaders." · What: Hype, a networking organization for young professionals ages 21 to 39. · When: 5:30 to 8 p.m. tonight · Where: Encore night club, 3473 Old Norcross Road, Duluth
More like this story
- Summit explains group's efforts to attract new jobs ( March 29, 2007 )
- Leaders discover new age of networking, one tweet at a time ( August 2, 2009 )
- Program gives discounts to school employees ( July 5, 2007 )
- Norcross appoints rep to Southwest Gwinnett Chamber ( February 3, 2014 )
- Suwanee festival to raise money for Relay For Life ( April 22, 2011 )


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Hornady Shellholder #35 (223 WSSM, 243 WSSM, 300 WSM)
Product #: 692398 Hornady #: 390575 UPC #: 090255905755
- Information
Precision machined from solid steel then heat treated to perform flawlessly for the life of the press. They fit all other Hornady accessories including the Hornady Cam-Lock Case Trimmer and Hand-Held Priming Tool. These shellholders will also fit the presses of most other brands in the industry.
Technical Information
Fits the following calibers:
223 Winchester Super Short Magnum (WSSM)
243 Winchester Super Short Magnum (WSSM)
25 Winchester Super Short Magnum (WSSM)
270 Winchester Short Magnum
7x61mm Sharpe & Hart
7mm Winchester Short Magnum
300 Winchester Short Magnum
325 Winchester Short Magnum
Technical Information
Fits the following calibers:
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How to make a playstand arch
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Citations et pensées positives | Créer ma vie, Julie Ouimet | '' Qui éveille la vie chez les autres contribue a donner un sens à la vie ! ~ Anselm Grün
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Homeschooling classes in Davis, CA through Wholistic Learning Resources. Handwork by Jennifer Tan of Syrendell.
Children Words, Jennifer Tans, Syrendel Workshop, Waldorf Children, Waldorf Inspiration, Wholist Learning, Homeschool Class, Learning Resources
Artistic geometry grade 6. Waldorf homeschooling. Syrendell.
6Th Grade, Artists Geometry, Secondary Prac, Waldorf Homeschool, Geometry Grade, Waldorf Inspiration, Homeschool Collection, Drawings Tutorials
Studying rocks, minerals, crystals. Waldorf homeschooling grade 6. Syrendell.
Homeschool Grade, Life Learning, 6Th Grade, Waldorf 6Th, Waldorf Homeschool, Pretty Things, Sixth Grade, Pretty Minerals, Study Rocks
Use tea strainers to make felted balls
Felting Wool Art, Felt Ball, Felting Wet Felting Wool
Felted Ball Tutorial
Blessing in the Chaos of New Beginnings - encouragement for the beginning of a new school year | Waldorf-Inspired Learning
Waldorf Inspiration Learning, Steiner Inspiration, Homeschool Inspiration, New Schools Years
Blessing in the Chaos of New Beginnings - encouragement for the beginning of a new school year.
Take a look at our Foreign Language in the Dell eBook for homeschooling parents and teachers!
The Giver Quartet Book Club for Teens, a one-year world history course online ⋆ Waldorf-Inspired Learning
Book Club, Teens Book, Middle Schools, Reading, The Giver, Schools Book, 35 Book, 1001 Book, 36 Book
100 top books to read by the end of middle school
merry hearts, felt ornaments with embroidered christmas trees
Idea, Christmas Crafts, Felt Christmas, Felt Ornaments, Christmas Ornaments, Merry Heart, Heart Ornaments, Felt Heart, Helen Philippe
merry hearts Christmas ornaments
christmas crafts idea
Felted Heart Ornaments
merry hearts, felt ornaments with embroidered christmas trees-if thesedontputasmile on your face your blind
Merry Hearts felt tree decorations #felt #christmas decoration idea
Helen Philipps: Merry Hearts http://helenphilipps.blogspot.jp/2010/12/merry-hearts.html Cute ornaments but this site also has TONS of other cute (all holidays) ideas http://helenphilipps.blogspot.jp/search?updated-max=2010-12-28T13:18:00Z&max-results=10
wooden stacker game for kids, gnome and elf in autumn colors
For Kids, Autumn Colors
Fall has arrived to the Magic Forest. It is a four-piece puzzle set, together 6,3 x 5,5 inch (16 x 14 cm) handmade with care of wood. (finished
Waldorf Style, Magic Forest
« Au rythme de la terre » programme pédagogique Steiner pour le Jardin d'enfants
Rythme De, Programme Pédagogique, For, Pédagogique Steiner, The Terre, Steiner Pour, Children Activities, Jardine D Enfants, Au Rythme
That bath tub though 20 AMAZING INSPIRATIONS FOR DECORATING WITH NATURE
Amazing Inspiration, Diy Home Decor, Decorating With Nature 2 Jpg, Good Ideas, Bath Tubs, Natural Decor, Natural Wood, Woods Ideas, Headboard Ideas
20 AMAZING INSPIRATIONS FOR DECORATING WITH NATURE- I like the headboard idea for our redwood slabs
20 AMAZING INSPIRATIONS FOR DECORATING WITH NATURE good ideas !!
Bring the #spring indoors! Check out these 20 innovative ways to #decorate with #nature for #inspiration! #DIY #home #decor
20 AMAZING INSPIRATIONS FOR DECORATING WITH NATURE raw natural wood ideas …shared by Vivikene
20 AMAZING INSPIRATIONS FOR DECORATING WITH NATURE #decor #diy
Small Tree Table from NordicHouse.co.uk. Each small table is carved from a tree trunk; preserving it's natural shape. This means that each table top is different. You could use it as a side table, or as a statement table. Definitely a conversation starter! £59.95.


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Waldorf Tuxedo Co Inc.Read MoreYou'll be the most stylish person at the party when you start shopping for apparel at Waldorf Tuxedo Co Inc.'s fine store in Albany. Don't let the cold bum you out this winter. Stay stylish with winter accessories from Waldorf Tuxedo Co Inc. Get a look (or two or three) that will last from day to night! This store is home to some of the hottest deals in women's fashion, so start shopping. Freshen up your wardrobe with an item from Waldorf Tuxedo Co Inc.. You will be looking better than ever. No matter what time of day you visit Waldorf Tuxedo Co Inc., you can find easy in-and-out parking for your hot ride.204 Lancaster StreetAlbany, NY US
Roberto's Italian DeliRead MoreRoberto's Italian Deli's fresh deli offerings attract lunchtime visitors looking for a simple sandwich or salad. When you're ready to pig out, Roberto's Italian Deli is ready to serve you the scrumptious food you're craving. Catering is also available if you'd like to serve Roberto's Italian Deli's tasty dishes at your next party. Ample parking is located near Roberto's Italian Deli. Fancy snacks do come at a higher price, but wow are they delicious.197 Lark StAlbany, NY US
Rolf's Pork StoreRead MoreWhether you're grilling, roasting, baking, or slicing, you can't go wrong with the meats at Rolf's Pork Store in Albany. For breads, cookies, cakes, and pies that will blow your mind, are couple extra sweet ingredients are kitchen must-haves. Get your grill fired up and grab your tongs! The meat here is perfect for the grill any time of year. There's great parking only a short distance from Rolf's Pork Store. You've tried the other meat suppliers in Albany. Now, it's time you tried true succulence at Rolf's Pork Store's butcher shop.70 Lexington AveAlbany, NY US
Capitol Hill DeliRead MoreDelicious cuisine set in a familiar vibe, Capitol Hill Deli features terrific coffee and tasty tea. It's a favorite spot for those seeking good food. Try to remember that business casual is the suggested attire. If you need food provided for a local event, take advantage of its catering options. Located in the heart of New York's capital, Capitol Hill Deli definitely won't leave you disappointed.42 Eagle StAlbany, NY US
Comedy WorksRead MoreLocated in Albany, Comedy Works is a well-known deli that delivers a delicious menu. This restaurant delivers an unforgettable dining experience set in a relaxed vibe. The great quality will make you a regular. If you need food provided for a local event, take advantage of its catering options. Located in the heart of New York's capital, you won't walk away from Comedy Works disappointed.142 State StAlbany, NY US
Canape ConnectionRead MoreTreat yourself to tasty, homemade barbecue at Canape Connection in Albany. The chefs at Canape Connection know how to prepare tasty, gluten-free and low-fat meals. You can also serve food from Canape Connection at your next party — the restaurant offers catering. At Canape Connection, diners can score a guaranteed parking spot close to the restaurant. It's not the cheapest, it's not the most expensive, but it is the most delicious. Come to Canape Connection for a great bite.44 Holland AveAlbany, NY US


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Mirelle's RestaurantRead MoreOne of the top-rated restaurants in Westbury, Mirelle's Restaurant has a laid-back atmosphere with a delicious menu. The excellent quality will make you a regular. It should be noted that dressy is the recommended attire. If you're on the lookout for the perfect spot for family or friends, it's been reviewed as a solid option for large groups and kids. If you need food provided for a local event, take advantage of its catering options. Or, if you just want to stop by for a beverage, the restaurant has a pretty broad selection at its bar. To sum everything up, Mirelle's definitely stands out from the rest. Don't worry about trying to find a spot on the street, as visitors to the restaurant do have access to a private parking lot nearby.170 Post AveWestbury, NY US
La Marmite RestaurantRead MoreFor a new spin on spaghetti and meatballs, try trendy hotspot La Marmite Restaurant. The menu at La Marmite Restaurant does not include any low-fat options, so come ready to indulge. Find the perfect vintage to complement your meal — La Marmite Restaurant offers a fine selection of wines, beers, and beyond. It's party time! Head to La Marmite Restaurant to share great food with a large group of friends. Call ahead for reservations to ensure your table is waiting for you when you arrive. Great place to bring the whole family with great food and a business casual dress code. Catering is also available if you'd like to serve La Marmite Restaurant's tasty dishes at your next party. La Marmite Restaurant provides a professional and quick valet service. Fancy snacks do come at a higher price, but wow are they delicious.234 Hillside AveWilliston Park, NY US
Bar FritesRead MoreThe cutting-edge French cuisine at Bar Frites is truly magnifique. The weekends are for going out for amazing combinations. Save the salad for the weekday and come grab a meal at Bar Frites. Round out your meal with a little tipple — Bar Frites has a terrific drink list, including beer, wine, and more. Tots are more than welcome to dine with their parents at Bar Frites. Bask in the sun (or moon!) light when you dine on Bar Frites' outdoor patio. Whether it's just you and a date or you're bringing the whole gang, it's best to call ahead and make a reservation. No need to dress up for a trip to Bar Frites — the casual restaurant encourages laid-back attire. For those in a rush, the restaurant lets you take your food to go. Catering makes it easier to organize any event, and Bar Frites will ensure that it is delicious. If your preferred mode of transit is of the two wheel variety, you're in luck — there's tons of bike parking outside the restaurant. Bar Frites is serving up five-star food at a reasonable price. The menu at Bar Frites includes breakfast, lunch, and dinner — stop by for your favorite meal.400 Wheatley PlzGreenvale, NY US
Barney's RestaurantRead MoreBarney's Restaurant is a relaxed restaurant with an elegant decor and classic American dishes. Low-fat and gluten-free options are featured on the menu. Take your pick of beer, wine, or other beverages offered on this restaurant's menu. Reserve a table in advance and steer clear of long wait times. Keep it casual at Barney's Restaurant, and save that little black dress for a different occasion. Feed the gang at your next get-together with catering from Barney's Restaurant as well. At Barney's Restaurant, you can find ample parking that is readily available any time of day. Checks are bigger than average at the restaurant, so prepare your wallet. Breakfast, lunch, and dinner are all served at the restaurant, but reviewers rate the dinner menu the highest. Indulge in all of your favorite American classics with a trip to the definitive standard in town at Barney's Restaurant. So head on over to the highly-rated Barney's Restaurant for some American eats and see what the buzz is all about.315 Buckram RdLocust Valley, NY US
CassisRead MoreYour next meal awaits at Cassis in Huntington. Sometimes there really is something for everyone, and not just something, something delicious. Come to Cassis for food that is gluten-free, low-fat, and even vegan. Enjoy a drink with your dinner — Cassis has a full bar to serve up a glass of wine, beer, or more. The patio seating at Cassis is perfect for those warm summer days. You'll want to save quiet conversations for another spot, though — the restaurant can get noisy. Call ahead for reservations to ensure your table is waiting for you when you arrive. Wear what you like when you dine at Cassis — the restaurant has a chill vibe just right for casual dining. Or, take your grub to go. It's time to gather up the party people. Serve them great food from Cassis. Diners at Cassis will love the free parking nearby. Prices are a bit on the higher side, so this might be a good pick for a special night out. All major credit cards are accepted. Reviewers rave about the dinner menu at the restaurant, though breakfast and lunch are also served.55 Wall StHuntington, NY US
Village Creperie CafeRead MoreLocated in Village Creperie Cafe, Village Creperie Cafe's crepes have a gooey inside and crisp outside. Village Creperie Cafe's menu features a little something for everyone, even those who prefer vegan, low-fat and gluten-free options. Getting online is easy with Village Creperie Cafe's free and convenient wifi. You can't reserve a table ahead of time at Village Creperie Cafe, so you may need to plan for a wait at prime times. No need to gussy up for a trip to Village Creperie Cafe, where patrons dress for comfort and fun. Or, take your food to go. Take the comfort of your own home and add great grub from Village Creperie Cafe to create the perfect night. Village Creperie Cafe is located near endless free parking options. When you need great food that is not going to cost an arm and a leg, stop by Village Creperie Cafe. The restaurant is known for its showstopper brunch, but they also offer lunch and dinner.335 New York AveHuntington, NY US


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Like the water that laps at the shore, this cerulean blue eyelet dress will clothe you in cool beauty. Sitting upon your picnic blanket, you can't help but admire the delicate eyelet fabric of this breezy dress and the way the circular pattern mirrors the clouds floating above you. Featuring a sweetheart neckline, adjustable straps, and a gathered waist, this fully lined dress pairs perfectly with red wedge sandals, a delicate gold bracelet, and round, mirrored sunnies for a look that's picnic perfection.
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