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291:H1822-H1828, 2006. First published 21 April 2006;
Am J Physiol Heart Circ Physiol
Bi-Hua Tan, Carmen R. Valdivia, Chunhua Song and Jonathan C. Makielski
background Q1077 and rescue by mexiletine
mutation G1406R depends on splice variant
Partial expression defect for the
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Partial expression defect for the SCN5A missense mutation G1406R depends
on splice variant background Q1077 and rescue by mexiletine
Bi-Hua Tan, Carmen R. Valdivia, Chunhua Song, and Jonathan C. Makielski
Section of Cardiovascular Medicine, Department of Medicine, University of Wisconsin, Madison, Wisconsin
Submitted 24 January 2006; accepted in final form 12 April 2006
Tan, Bi-Hua, Carmen R. Valdivia, Chunhua Song, and
Jonathan C. Makielski. Partial expression defect for the SCN5A
missense mutation G1406R depends on splice variant background
Q1077 and rescue by mexiletine. Am J Physiol Heart Circ Physiol
291:H1822–H1828, 2006.First
doi:10.1152/ajpheart.00101.2006.—Mutations in the cardiac Na?
channel gene SCN5A cause loss of function and underlie arrhythmia
syndromes. SCN5A in humans has two splice variants, one lacking a
glutamine at position 1077 (Q1077del) and one containing Q1077. We
investigated the effect of splice variant background on loss of function
and rescue for G1406R, a mutation reported to cause Brugada syn-
drome. Mutant and wild-type (WT) channels in both backgrounds
were transfected into HEK-293 cells and incubated for up to 72 h with
and without mexiletine. At 8 h, neither current nor cell surface
expression was observed for the mutant in either background, but both
were present in WT channels. At 24 h, small (?10% compared with
WT) currents were noted and accompanied by cell surface expression.
At 48 h, current density was ?40% of WT channels for the mutant in
the Q1077del variant background but remained at ?10% of WT
channels in Q1077. Current levels were stable by 72 h. Coexpression
with ?1- or ?3-subunits or insertion of the polymorphism H558R in
the background did not significantly affect current expression. Mex-
iletine restored current density of the mutant channel in both back-
grounds to nearly WT levels. The mutant channels also showed a
negative shift in inactivation, slower recovery, and enhanced slow
inactivation, consistent with a loss of function phenotype. These data
show that a trafficking defect may be partial and time dependent and
may differ with the splice variant background. Also, expression
defects and gating abnormalities may contribute to loss of function for
the same mutation.
published April21, 2006;
sodium channels; mexiletine rescue
THE VOLTAGE-DEPENDENT cardiac Na?channel ?-subunit pore-
forming protein in human heart is encoded by SCN5A. This
channel is responsible for a large peak inward Na?current
(INa), which underlies excitability and conduction in working
myocardium. Alternative splicing of a single amino acid at the
beginning of exon 18 causes insertion of glutamine at position
1077 (Q1077), resulting in two splice variants, one that forms
a 2,016-amino acid protein designated Q1077 and a 2,015-
amino acid protein that is designated Q1077del (11). Messen-
ger RNA for these two splice variants was present in every
human heart examined in a ratio of ?2:1, with a 65% predom-
inance of the shorter 2,015-amino acid variant Q1077del (11).
The longer and less abundant Q1077 background was used in
most studies of mutations in SCN5A (6).
Abnormalities in INaassociated with loss of function under-
lie heritable arrhythmia syndromes such as Brugada syndrome,
progressive cardiac conduction disease, and congenital sick
sinus syndrome (9). Loss of function can occur because of
altered channel gating (5) or decreased expression of channels
at the cell surface (2, 3). Mechanisms for loss of expression are
likely to be complex. The full spectrum of expression defects
for ion channels in general and for SCN5A in particular is just
beginning to be described. Previously we showed that the
common polymorphisms H558R and S524Y show decreased
surface expression only when expressed in the Q1077 back-
ground (15). We hypothesized that splice variant background
might also affect other mutations, causing loss of function. The
mutation G1406R was previously reported as a Brugada syn-
drome mutation (10); we made this mutation in the Q1077del
and Q1077 backgrounds and assessed the time dependence of
cell surface expression by voltage clamp and by in situ immu-
nocytochemistry and confocal microscopy. These results show
that, in HEK-293 cells, expression defects in SCN5A are not all
or none, they can be time dependent, and they can be modu-
lated by splice variant background and drugs.
Site-directed mutagenesis, heterologous expression, and drug
treatment. The G1406R mutation was created by site-direct mutagen-
esis (mutagenesis kit from Stratagene) using a PCR technique. The
appropriate nucleotide changes for G1406R were engineered into two
common splice variants of human cardiac voltage-dependent Na?
channel SCN5A/hNav1.5 [one lacks glutamine at position 1077
(Q1077del; GenBank accession no. AY148488) and the other contains
Q1077 (Q1077; GenBank accession no. AC1377587)] in the pcDNA3
vector (Invitrogen, Carlsbad, CA). The integrity of the constructs was
verified by DNA sequencing. Wild-type (WT) and mutant channels in
these two splice variants of SCN5A were transiently transfected in
HEK-293 cells as described previously (13, 18). After 3–5 h of
incubation, Super Fect (Qiagen, Valencia, CA) transfection reagent-
DNA mixture was replaced with 3 ml of normal culture medium with
or without 500 ?M mexiletine, and the cells were incubated at 37°C
for 1 or 2 days. Before the electrophysiological recording, the plates
containing the cells were removed from the 37°C incubator, growth
medium was aspirated off the plates with or without drug, and the
cells were treated with a 0.25% trypsin-1 mM EDTA solution
(GIBCO-BRL) and transferred to a fresh tube along with 2 ml of
normal culture medium and directly to the experimental chamber for
electrophysiological recording.
Standard electrophysiological measurements for functional char-
acterization. Macroscopic INa was measured using a standard whole
cell patch-clamp method at 22–24°C, as described previously (13).
The extracellular (bath) solution contained (mmol/l) 140 NaCl, 4 KCl,
1.8 CaCl2, 0.75 MgCl2, and 5 HEPES (with pH adjusted to 7.4 with
NaOH). The pipette solution contained (mmol/l) 120 CsF, 20 CsCl, 2
EGTA, and 5 HEPES (with pH adjusted to 7.4 with CsOH). Resis-
tance of pipettes filled with recording solution was 1.0–2.0 M?. The
Address for reprint requests and other correspondence: J. C. Makielski,
Dept. of Medicine, Univ. of Wisconsin, 600 Highland Ave. H6/349, Madison,
WI 53792 (e-mail: email@example.com).
The costs of publication of this article were defrayed in part by the payment
of page charges. The article must therefore be hereby marked "advertisement"
in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
Am J Physiol Heart Circ Physiol 291: H1822–H1828, 2006.
First published April 21, 2006; doi:10.1152/ajpheart.00101.2006.
0363-6135/06 $8.00 Copyright © 2006 the American Physiological Societyhttp://www.ajpheart.orgH1822
on October 13, 2011
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data were acquired using pClamp 8.2 (Axon Instruments, Union City,
CA) and analyzed using Clampfit (Axon Instruments). The standard
voltage-clamp protocols are presented with the data and as described
previously (15).
Immunocytochemistry. The FLAG epitope was introduced between
S1 and S2 in domain I of SCN5A for the immunocytochemistry
experiments. Transfected and nontransfected HEK-293 cells were
fixed with 4% paraformaldehyde for 15 min, permeated with 0.1%
Triton X-100 for 10 min, and quenched with 0.75% glycine for 10 min
at room temperature. Then the cells were blocked with blocking buffer
(10% goat serum and 5 mM NaN3-PBS) and incubated at 37°C for 30
min. After the blocking procedure, the cells were incubated for 1 h at
37°C with a 1:200 dilution of mouse anti-FLAG M2 primary antibody
(Stratagene) against the FLAG-tagged ?-subunit of the Na?channel
and rabbit anti-calnexin NH2-terminal polyclonal antibody (StressGen
Bioreagents, Victoria, BC, Canada) for endoplasmic reticulum (ER)
labeling at a ratio of 1:250. The cells were washed with blocking
buffer before 1:250 fluorescein-conjugated goat anti-mouse and 1:300
fluorescein-conjugated goat anti-rabbit antibodies (Molecular Probes,
Eugene, OR) were applied as the secondary antibody and allowed to
react for 1 h at 37°C.
Confocal laser microscopy. Fluorescent probe-labeled HEK-293
cells were viewed using a confocal imaging system (model MRC-
1024, Bio-Rad) equipped with a krypton-argon laser beam and
mounted on an inverted microscope (Diaphot 200, Nikon). A ?60 oil
immersion lens with a 1.4 NA was used. The microscope was
controlled by the Lasersharp 2000 program (Bio-Rad). A Kalman
collection filter with four frames per image was applied to record the
image. Z series were created by sequential scanning of green and red
channels at 0.2-mm steps. Single sections were exported to Adobe
Photoshop 6.0 for final image processing.
Statistical analysis. Values are means ? SE. Determinations of
statistical significance were performed using Student's t-test for com-
parisons of two means or analysis of variance for comparisons of
multiple means. P ? 0.05 was considered statistically significant.
Curve fits were performed using pClamp 8.2 (Axon Instruments).
Nonlinear curve fitting was performed with Origin 6.0 (Microcal
Time-dependent expression and mexiletine rescue for
G1406R in the two backgrounds. WT and G1406R mutant
channels in the two common splice variant backgrounds
Q1077del and Q1077 were voltage clamped after 24 and 48 h
of incubation with and without 500 ?M mexiletine. Represen-
tative current traces for WT and G1406R channels in the
Q1077del background are shown in Fig. 1A, with summary
data in Fig. 1B; representative current traces for WT and
G1406R channels in the Q1077 background are shown in Fig.
2A, with summary data in Fig. 2B. The current levels for
WT-Q1077del (Fig. 1B) and WT-Q1077 (Fig. 2B) tended to
increase modestly with time and with exposure to mexiletine,
but this did not reach statistical significance. At 24 h, the
expression defect for the G1406R mutant is profound in both
backgrounds, with 3.4% of WT levels for Q1077del (Fig. 1B)
and 9.4% of WT levels for Q1077 (Fig. 2B). At 48 h, the
current levels for G1406R in Q1077del had increased signifi-
cantly to ?133 ? 27 pA/pF compared with 24-h levels of
?11 ? 4 pA/pF (Figs. 1B and 3), whereas in the Q1077
background even with ?48 h of incubation, the current levels
of G1406R remained severely depressed at only ?34 ? 8
pA/pF, which was significantly lower than in the Q1077del
background (Figs. 2B and 3). Incubation in mexiletine in-
creased currents dramatically and significantly for the mutant
channel in both backgrounds, with levels reaching nearly WT
levels. Currents were measured after washout of mexiletine,
which was present only during the incubation period. Expres-
sion of the G1406R mutants in either background did not
Fig. 1. Partial expression defect and mexiletine rescue
for G1406R channel in the Q1077del background. A:
whole cell current traces from representative G1406R
and wild-type (WT) channels without (left) and with
(right) mexiletine treatment. B: summary of Na?cur-
rent (INa) density in G1406R and WT after 24 and 48 h
of incubation with and without mexiletine. Values are
means ? SE of number of experiments shown in pa-
rentheses above bars. *Significant difference between
G1406R after 24 h of incubation without mexiletine and
with mexiletine or WT after 24 h incubation (P ?
0.0001). †Significant difference between G1406R after
48 h of incubation without mexiletine and with mexil-
etine or WT after 24 h of incubation (P ? 0.03).
§Significant difference between 24 and 48 h of incuba-
tion without mexiletine (P ? 0.0001).
AJP-Heart Circ Physiol • VOL 291 • OCTOBER 2006 • www.ajpheart.org
on October 13, 2011
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increase at 72 h (Fig. 3) and remained at ?33% in Q1077del
and 10% in Q1077.
Voltage-dependent gating properties of "rescued" G1406R
in the two splice variants of SCN5A. The voltage-dependent
gating properties of G1406R channels with and without mex-
iletine in the Q1077del splice variant background are compared
with those of WT channels in Fig. 4; summary data for the
fitted kinetic parameters are shown in Table 1. The comparable
data for G1406R in the Q1077 splice variant background are
shown in Fig. 5 and Table 2. Activation of the channel was the
same for both WT backgrounds and for the mutation in both
backgrounds and was unaffected by previous incubation in
mexiletine (Figs. 4A and 5A). For steady-state inactivation,
however, the midpoints were significantly shifted by ?7 mV
for G1406R compared with WT in the Q1077del variant and by
?10 mV for G1406R compared with WT in the Q1077
background (Figs. 4B and 5B). Slower time constants of
recovery were observed for G1406R than for WT in both
backgrounds (Figs. 4C and 5C). Finally, a protocol was de-
signed to measure the component of current inactivated in a
prepulse that cannot recover quickly. This inactivation, which
is sometimes called intermediate, slow, and ultraslow inacti-
vation, depending on the length of the prepulse, will be referred
to collectively as slow inactivation. Slow inactivation was
significantly greater in mutant than in WT channels, with
statistical significance demonstrated for prepulse durations as
long as 6 s (Figs. 4D and 5D). Late INa, measured 720 ms after
the initial depolarization, was 0.4–1.2% of peak current and
was not significantly different from that of WT channels (data
not shown). In all cases, previous incubation with mexiletine
did not increase the relative late current, nor did it alter
voltage-dependent gating.
Na?channel protein expression with and without drug
treatment. WT and mutant Na?channels were labeled using
the FLAG epitope, expressed in the HEK-293 cells, and ex-
amined by voltage clamp and confocal microscopy (Figs. 6 and
7). As shown by the representative current traces in Figs. 6A
and 7A, the currents were unaffected by the presence of the
FLAG epitope. The cells were labeled with anti-FLAG anti-
body to mark the location of channels and with anti-calnexin
antibody (Figs. 6B and 7B). Calnexin, a chaperon protein
Fig. 2. Partial expression defect and mexiletine rescue
for G1406R channel in the Q1077 background. A:
whole cell current traces as in Fig. 1, except in Q1077
background. B: summary of INa density in G1406R and
WT after 24 and 48 h of incubation with and without
mexiletine. Values are means ? SE of number of
experiments shown in parentheses above bars. *Signif-
icant difference between G1406R after 24 h of incuba-
tion without mexiletine and with mexiletine or WT after
24 h of incubation (P ? 0.0001). †Significant difference
between G1406R after 48 h of incubation without mex-
iletine and with mexiletine or WT after 24 h of incuba-
tion (P ? 0.001).
Fig. 3. Time-dependent expression of INadensity of G1406R channel normal-
ized to WT levels in Q1077del and Q1077 backgrounds showing no increase
in current densities after 48 h. Data are normalized to WT densities at the same
time point. Values are means ? SE of number of experiments shown in
parentheses above bars. *Significant increase after 48 h of incubation (P ?
0.0001). †Significant difference between Q1077 and Q1077del background
after 48 h, even at 72 h, of incubation (P ? 0.05).
AJP-Heart Circ Physiol • VOL 291 • OCTOBER 2006 • www.ajpheart.org
on October 13, 2011
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present in the ER, was used as an ER marker (8). Expression
of the protein at the cell surface is demonstrated by a rim of
fluorescence, as seen in the WT controls (Figs. 6B and 7B).
These results show little expression at the cell surface for the
mutation in either background at 8 h, whereas expression of the
WT at the surface is robust at 8 h (Figs. 6B and 7B). Cell
surface expression of the mutations for both backgrounds is
also noted after 48 h and in the presence of mexiletine,
consistent with the current expression data. These results show
that the current expression defect is caused by a decrease in
channel expression at the cell surface and that the defect
appears to be a slowed and incomplete channel expression at
the cell surface. Other attempts to restore the current density in
G1406R, such as coexpression with the ?1- and ?3-subunits
and inclusion of the common polymorphism H558R, which
rescued the expression of M1766L (18), failed to restore the
current densities for G1406R in the two splice variants (data
not shown).
This study shows that the SCN5A mutation G1406R causes
a partial trafficking defect with slowed and incomplete expres-
sion relative to WT channels and that the severity of the defect
Fig. 4. Voltage-dependent gating for G1406R and WT channels with and without prior incubation in mexiletine (MEX) in Q1077del variant background. A:
voltage dependence of activation for G1406R and WT with and without mexiletine. Line represents a fit to the Boltzmann function: Na?conductance (GNa) ?
[1 ? exp(V1/2 ? V)/k]?1, where V1/2 and k are midpoint and slope factor (as an index of voltage control, all factors were ?4), respectively, and GNa ?
INa(norm)/(V ? Vrev), where Vrev is reversal potential and V is membrane potential. B: steady-state availability from inactivation for G1406R and WT with and
without mexiletine. Line represents a fit to the Boltzmann function: INa? INa-max[1 ? exp(Vc? V1/2)/k]?1, where V1/2and k represent midpoint and slope factor,
respectively, and Vcis membrane potential. C: recovery from inactivation for G1406R and WT with time on a logarithmic scale to better show early time course
of recovery. Recovery time course was best fit with 2 exponentials: normalized INa ? [Af exp(?t/?f)] ? [As exp(?t/?s)], where t is recovery time interval, ?f
and ?s represent fast and slow time constants, respectively, and Af and As represent fractional amplitude of fast and slow recovery components, respectively. D:
slow inactivation for G1406R and WT with prepulse duration on a logarithmic time scale. Insets: diagrams of voltage protocols. Values are means ? SE; n and
fit parameters are given in Table 1.
Table 1. Voltage-dependent gating parameters of G1406R and WT channels with and
without mexiletine in Q1077del background
V1/2, mV
Activation Inactivation
?f, ms
?s, ms
As, %
WT-Q1077del ? MEX
G1406R/Q1077del ? MEX
?46.9?1.2 (8)
?46.4?1.6 (7)
?43.5?1.7 (12)
?43.8?1.2 (13)
?81.8?1.3 (8)
?82.0?1.8 (7)
24.1?1.6 (8)
21.4?1.7 (8)
21.8?1.9 (12)
21.1?2.9 (13)
Values are means ? SE for number of experiments in parentheses. Parameters were obtained from fitting individual experiments (Fig. 4, A–C) to appropriate
model equations. For Boltzman fits, V1/2is midpoint of activation and inactivation. For double-exponential fits, parameters of recovery are fast time constant (?f),
slow time constant (?s), and fractional amplitude of slow component (As). All parameters were analyzed by one-way ANOVA across the wild-type (WT) and
mutant channel with and without mexiletine (MEX). *Significantly different from WT.
AJP-Heart Circ Physiol • VOL 291 • OCTOBER 2006 • www.ajpheart.org
on October 13, 2011
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Diversity and Inclusiveness at Adams State University
We all should know that diversity makes for a rich tapestry, and we
must understand that all the threads of the tapestry are equal in value
no matter what their color.
-Maya Angelou
Gender-Neutral Bathroom Signs Focus on What's Inside — The Toilet
A new pilot program will be utilizing free gender neutral bathroom signs generously donated in collaboration with GLAAD. "The restroom is a touchy subject. No one really wants to say 'toilet' (or loo, or commode). You just want to know where to go when you gotta go. And we get that. All-gender restroom signs alleviate the confusion. We're highlighting what's behind the stall with a handy, familiar graphic." The icon is from The Good Men Project and Sam Killermann at It's Pronounced Metrosexual. His site offers resources to "advance social equity…that help people to be better people." http://www.mydoorsign.com/all-gender-restroom-signs
Diversity at Adams State
ASU Faculty Lecture will examine use of southwestern plants
In the past few years, Duran has become interested in ethnobotany, the scientific study of the relationships between people and plants.
Lifeways Lecture "Curandismo: Our Healing Hand, Our Healing Lands" is October 15
Vigil is a rural herbal practitioner who is familiar with natural healing methods that are traditional to the upper Rio Grande bioregion.
Adams State will host Special Olympics Bowling Tournament
The Special Olympics athletes gear up for this tournament, training their hearts out, and nothing would be better than to show your support as they showcase their hard work.
Adams State represents the rainbow
Adams State University students, faculty, staff and community members gathered for an ice cream social and a group "rainbow" photo in recognition of the Standing Strong Equality Project.
Adams State University Student Support Services grant is renewed
The Adams State SSS proposal received a perfect score on the application.


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Brazzle Berry Menlo ParkRead MoreAmong the flavors offered every day at Brazzle Berry, acai berry is probably the most unusual. But it's this nutrient-packed berry that the yogurt shop centers itself around. Acai bowls blend the berry with banana and agave sweetener for a breakfast chock-full of vitamins and nutrients, while the yogurt provides a more effective way to get antioxidants than wooing fickle artichoke hearts. Besides acai berry, customers can choose from a range of all-natural yogurt flavors to fill their cups. Chocolate and strawberry are on the bill every day, while rotating flavors include peanut butter and red velvet. And to enhance their healthy sweet treats, customers spoon up toppings, such as chopped fruits and nuts, candy, and cookies.1201 University,Menlo Park,Menlo ParkMenlo Park, CA US
Le BoulangerRead MoreFollow your nose to Le Boulanger for an always needed sweet treat. Plan to indulge a bit at Le Boulanger, though, because they don't offer any low-fat fare. Eat out with the little ones at Le Boulanger, and don't waste time scurrying for a sitter. At Le Boulanger, the prime seating is on the patio. Come check out what all the buzz is about. Enjoy wifi here free of cost. Bring your furry friend to the bakery — Le Boulanger allows dogs to dine, too. Grab your meal to go at Le Boulanger if you're in a hurry — or better yet, have them bring it to you through their delivery service! Bring the Le Boulanger's great food to your place. For quick and easy parking near Le Boulanger, park on the street. Make use of the safe and efficient bike parking at Le Boulanger. When you need great food that is not going to cost an arm and a leg, stop by Le Boulanger.720 Santa Cruz AveMenlo Park, CA US
Martha's PastriesRead MoreVisit Martha's Pastries for a freshly baked treat. Martha's Pastries is a haven for fans of low-fat fare, and healthy living is promoted through a fresh and flavorful menu. You'll find most people wearing their favorite T-shirt and pair of jeans, as casual dining is Martha's Pastries' style. Martha's Pastries is known for serving great food, and they are able to serve it at your next event with their excellent catering. The restaurant offers free parking in the lot next door. Prices at Martha's Pastries are super affordable.325 Sharon Park DrMenlo Park, CA US
Posh BagelRead MoreTreat yourself to a bagel from Posh Bagel, and take your breakfast on-the-go. For fresh and healthy meal choices, dine at Posh Bagel. The restaurant has catering services as well. Ample parking is available in the area. If cycling is more your speed, you'll find plenty of space to stash your bike outside the restaurant. Prices are rock bottom at Posh Bagel, so load up on snacks and treats.869 Santa Cruz AveMenlo Park, CA US
Studio CakeRead MoreFor a quick breakfast on-the-go or a sweet afternoon pick-me-up, you can't go wrong with Studio Cake. All sweet cravings can be fulfilled with the decadent cakes and pastries here. With parking onsite, it's easier to get straight to our delicious food. Make use of the safe and efficient bike parking at Studio Cake. You'll pay a bit more than average for something to nibble on at Studio Cake.104 Gilbert AveMenlo Park, CA US
Gerry's CakesRead MoreEnjoy blissful bakery bites at Gerry's Cakes. A healthy lifestyle starts with the food you eat, and Gerry's Cakes is creating innovative healthy meals. Gerry's Cakes can also cater your next party; call today for details. The restaurant offers free parking in the lot next door. You won't find better prices in town than at Gerry's Cakes, so grab all the snacks you can carry.1141 Chestnut StMenlo Park, CA US


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Me, Myself & Ira - Scene 1
Get Your Gay Access Now!
DVD Title Me, Myself & Ira
Category Gay
Added April 19, 1999
Viewed 5,036 times
Favored 20 times Add to favorites
Duration 11m, 43s
- This scene does not have any comments yet!
Gorgeous blonde Cory Adams lays chilling in bed, and he's awakened by a phone call from his lover. They playfully flirt with each other, and he starts to stroke his hard dick as they talk dirty to each other. He slowly jacks off as they have phone sex, and he gets on his hands and knees and masturbates while breathing heavily into the phone. He's prompted to stroke himself harder and faster, and he lays back again as his toes curl while he gets closer and closer. He finally jerks his hot load all over his own stomach, getting off before he gets off the phone.
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Me, Myself & Ira
April 19 1999
More Scenes From DVD
- Scene 1 - Cory Has Phone Sex And Jerks Off
- Scene 2 - Muscluar Stud Masturbates Poolside
- Scene 3 - Dante's Peak Gets Jerked Off in a Solo
- Scene 4 - Wade Hanson in a Solo Demonstration
- Scene 5 - Lonely Blonde Hunk J/O In Backyard
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text: Burma Page 1 of 2 Next Page > Damage multiplies in monsoon-soaked, cyclone-smashed Myanmar By Anna K. PoolePosted Aug. 12, 2015Myanmar | Monsoon floods are surging through Myanmar, also known as Burma, triggering some of the worst flash floods and landslides in the nation's recent history. [http://www.worldmag.com/2015/08/damage_multiplies_in_monsoon_soaked_cyclone_smashed_myanmar] New Myanmar law regulates interfaith marriage By Anna K. PoolePosted July 15, 2015Myanmar | Human rights groups are blasting a new law adopted last week in Myanmar, also known as Burma, requiring women to register their intent to marry outside their… [http://www.worldmag.com/2015/07/new_myanmar_law_regulates_interfaith_marriage] Myanmar's parliament shoots down vote to lessen military control By Anna K. PoolePosted July 1, 2015Myanmar | Myanmar's recent transition toward democracy is still haunted by a half-century of brutal military dictatorship and a junta-era constitution. Last week, [http://www.worldmag.com/2015/07/myanmar_s_parliament_shoots_down_vote_to_lessen_military_control] Myanmar claims Rohingya are seeking better jobs, not fleeing persecution By Anna K. PoolePosted June 9, 2015Persecution | Myanmar is sick of the Rohingya crisis. In recent weeks, members of the nation's Muslim minority have captured international attention—including from the… [http://www.worldmag.com/2015/06/myanmar_claims_rohingya_are_seeking_better_jobs_not_fleeing_persecution] New Myanmar law mandates three years between pregnancies By Anna K. PoolePosted May 27, 2015Myanmar | Myanmar, a freshly forged democracy still shaking off a history of military dictatorship, enacted a highly controversial population law over the weekend… [http://www.worldmag.com/2015/05/new_myanmar_law_mandates_three_years_between_pregnancies] Myanmar's marginalized Muslims earn country UN rebuke By Anna K. PoolePosted April 29, 2015Myanmar | With a half-century of military dictatorial skin to shed, Myanmar is only just beginning to emerge a democracy. As presidential elections approach, [http://www.worldmag.com/2015/04/myanmar_s_marginalized_muslims_earn_country_un_rebuke] Globe Trot: Obama to skip Armenian genocide commemoration By Mindy BelzPosted April 22, 2015International | TURKEY: U.S. President Barack Obama will not use the word "genocide" this year when commemorating the deaths of 1.5 million Armenians at the… [http://www.worldmag.com/2015/04/globe_trot_obama_to_skip_armenian_genocide_commemoration] Kachin casualties By Angela LuPosted April 17, 2015Burma | Burma has signed a cease-fire with opposing ethnic groups, but the fighting hasn't stopped and diplomacy may be failing [http://www.worldmag.com/2015/04/kachin_casualties] Convert to Christianity in Burma? Get government permission first By Julia A. SeymourPosted Feb. 9, 2015Persecution | Persecution of Christians and other religious minorities in Burma, also called Myanmar, is expected to worsen if a new religious conversion bill makes it into… [http://www.worldmag.com/2015/02/convert_to_christianity_in_burma_get_government_permission_first] Globe Trot: CIA chief snubs president to defend interrogation tactics By Mindy BelzPosted Dec. 12, 2014International | NATIONAL SECURITY: CIA Director John Brennan—in a forceful break with the president—held a press conference yesterday to respond to a Senate report… [http://www.worldmag.com/2014/12/globe_trot_cia_chief_snubs_president_to_defend_interrogation_tactics] Globe Trot: On the brink of war in Ukraine By Mindy BelzPosted Nov. 14, 2014International | UKRAINE:Technically a ceasefire has been in effect in eastern Ukraine since September, but war is looming, as NATO continues to report increased Russian troop… [http://www.worldmag.com/2014/11/globe_trot_on_the_brink_of_war_in_ukraine] Globe Trot: U.S. taxpayer money could be headed for Ukraine By Mindy BelzPosted Feb. 3, 2014International | UKRAINE: President Viktor Yanukovych is back at work today amid intensified calls from demonstrators that he resign and call early elections. [http://www.worldmag.com/2014/02/globe_trot_u_s_taxpayer_money_could_be_headed_for_ukraine] Page 1 of 2 Next Page >


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People In The News
Related Searches:
166 - 180 of 1258 results
February 28, 2012
Eric Barta has been promoted to regional sales manager for the midwest region. Barta has been a technical sales representative in the midwest region for the last eight years and has over 20 years' experience in sales.… Read More »
February 27, 2012
Dale MacDonald, group vice president, coatings specialties, Ashland Specialty Ingredients, has been nominated to the American Coatings Association's (ACA) board of directors. MacDonald, will serve a three-year term through April 2015. MacDonal… Read More »
February 27, 2012
John Steitz has been elected president and chief operating officer of Albemarle Corporation, effective March 1, 2012. Steitz will oversee all aspects of the company's operations, including global responsibility for manufacturing, supply chain, sa… Read More »
International Paint LLC promotes Chris McMillan to protective coatings marketing manager, North America
February 21, 2012
International Paint LLC, has promoted Chris McMillan to protective coatings marketing manager, North America. In this new role, McMillan will be responsible for managing and overseeing all of the product marketing and marketing communications… Read More »
February 21, 2012
RPM International Inc. has elected Russell Gordon, currently vice president, corporate planning, as vice president and chief financial officer effective April 10, 2012. Gordon is replacing Robert Matejka, RPM's current senior vice president and… Read More »
February 16, 2012
Ross McKenzie, president and chief executive of Sumter Coatings, Inc. has retired having served in the paint and coatings industry with DuPont, Southern Coatings, Inc., Pratt & Lambert, Inc., and Sumter Coatings, Inc. over the course of 70 years.… Read More »
February 16, 2012
Mark Wright has joined Aakash Chemicals as the company's new regional manager. Prior to joining Aakash Chemicals, he worked for DayGlo Color Corp. for more than 20 years, serving as vice president of sales the last five. His experience includes c… Read More »
February 15, 2012
Emerald Polymer Additives, a division of Emerald Performance Materials, has named John Zuppo general manager of lubricant and plastic antioxidant product lines. In this role, Zuppo will be responsible for overseeing current operations, as well as new… Read More »
February 15, 2012
Ace Hardware Corporation has appointed John Venhuizen chief operating officer. Venhuizen has spent nearly two decades with Ace and most recently served as executive vice president of supply chain, information technology and international. In this pos… Read More »
February 15, 2012
Gerard Metzer has been appointed the marketing director of Plascon. In his new position, he brings a 25-year local and international record of accomplishment across the painting, coating, building materials and garden and home improvement industries.… Read More »
February 14, 2012
Ferguson Chemical Innovation has named Riki Gogna its new business line sales manager for the coatings, adhesives and sealants group (CAS), responsible for the development and management of the company's CAS sales group in Canada. Gogna is a r… Read More »
February 13, 2012
Steven Shifman, president and CEO of Michelman, Inc., has been appointed to serve on the TechSolve board of directors. As a TechSolve board member Shifman will provide guidance on TechSolve's overall strategic direction, mission and growth plan… Read More »
Robert Taylor of AkzoNobel Decorative Paints nominated to the American Coatings Association board of directors
February 8, 2012
Robert Taylor, president of AkzoNobel's North American decorative paints business, has been nominated to the American Coatings Association's (ACA) board of directors and executive committee. Taylor will serve a three-year term, until Apri… Read More »
February 3, 2012
Robert Shengkui Hu has joined The HallStar Company's senior management team as vice president, research and development. He will initially report to and replace Gary Wentworth, who will retire from the specialty chemical company this year after… Read More »
February 3, 2012
David Baumstark has taken over the role as president of Archway Sales. Over the past several years, Baumstark held the leading management role within Archway's marketing and strategy committees while directing all of the company's sales effor… Read More »
166 - 180 of 1258 results


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Tesoro Corp. will halt refining at its 93,700-b/cd Kapolei refinery in Hawaii after a year-long effort to sell the facility proved unsuccessful (OGJ Online, Jan. 11, 2012).
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offline search engineAlso called a local search engine, an offline search engine is designed to be used for offline PC, CDROM or LAN searching usage. For example, a Web site can be indexed and a local search engine used if the author wanted to distribute the Web site on CD or DVD.
Stay up to date on the latest developments in Internet terminology with a free weekly newsletter from Webopedia. Join to subscribe now.
From wacky alarm clocks to lecture hall tools and after class entertainment, these Android apps are a good fit for a student's life and budget. Read More »Sharing Threat Intelligence
A growing number of startups make the sharing of threat intelligence a key part of their solutions. Read More »Smiley Faces and Symbols
A text smiley face is used to convey a facial expression or emotion in texting and online chat conversations. This Webopedia guide shows you how... Read More »
The Open System Interconnection (OSI) model defines a networking framework to implement protocols in seven layers. Use this handy guide to compare... Read More »Network Fundamentals Study Guide
Networking fundamentals teaches the building blocks of modern network design. Learn different types of networks, concepts, architecture and... Read More »Computer Architecture Study Guide
This Webopedia study guide describes the different parts of a computer system and their relations. Read More »


text:
Constanza Ceruti
Photograph courtesy Constanza Ceruti
For the handful of people who pursue it, high-altitude archaeology is not only a career but a calling. Constanza Ceruti is one of the few scientists, and the world's only woman, to choose the challenging field. As she explained, "Few mountain climbers will be happy to spend a month working at the top after reaching a summit. On the other hand, most archaeologists will not enjoy the harsh climbing conditions. You have to like both mountaineering and archaeology very much to commit to this work."
For Ceruti, the calling came early. At ten she was keenly interested in anthropology, ancient religions, and nature. By 14 she knew high-altitude archaeology in her native Argentina was the perfect way to combine those passions. A degree in anthropology from the University of Buenos Aires followed, then a Ph.D. in history from the University of Cuyo in Mendoza.
Now a professor at Catholic University in Salta, Argentina, Ceruti specializes in exploring and excavating Inca Empire ceremonial centers on the summits of sacred Andean mountains.
She has climbed and performed archaeological research on more than a hundred mountains above 16,500 feet. Just to reach the bases of distant peaks, she has endured lightning storms, blizzards, gale winds, low oxygen levels, frostbite, and 60-mile hikes.
Unfazed, she notes, "Just think of the Incas who made these ascents 400 years before the advent of modern mountaineering. They looked for the slope offering the easiest route up. That still makes sense today and improves my chance of encountering traces of their presence."
Mountaintop worship sites are not found in other ancient cultures, a fact that has political as well as religious explanations. As the Inca expanded their empire, designating summits as sacred served to mark new territory as their own.
Perhaps Ceruti's most impressive find took place on the 22,100-foot summit of Llullaillaco Volcano, where the expedition she co-led unearthed the three best preserved mummies ever discovered. With hair still visible on arms, the mummies looked as if they had just been buried rather than frozen for 500 years. Elaborate gold and silver statues, ornate textiles, even pottery still containing food were also excavated.
The team braved driving snow and 70-mile-an-hour winds to complete their work, but for Ceruti the conditions posed no deterrent. "When we found the mummies, I remember a profound silence falling over the group. It is so humbling to look into the eyes of another human being from half a millennium ago."
"These mountains are so remote," she says. "Not only am I often the first archaeologist on the site but the first modern person to arrive since the Incas. It's amazing to enter a sacred place where I know the last human footsteps were those of Inca priests."
Interpretation of Ceruti's finds takes place back in the laboratory. "No one ever witnessed a mountaintop ceremony," she says. "So to bring these tangible remains alive again takes a lot of detective work. Why were some mountains considered sacred and others not? Why did some sites have simple shrines while others contained much more complicated ceremonial complexes? By considering archaeological evidence, historical sources from the time of the Spanish conquest, and traditional beliefs that still exist, we can reconstruct what these ancient sites looked like, the symbolic meaning behind each artifact, and how ceremonies took place.
"With this cultural and historical context," she says, "we can better explain things that happen today and help ensure these important areas will be protected. Some have already been destroyed by looters, so our work is very urgent. Finding and preserving these unique sites before they are destroyed allows me to give something back to the mountains. For me, studying these sacred summits is a life commitment. There's something about being up here that is phenomenal scientifically, culturally, and spiritually."
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Healthy Living Market and Café's annual Thanksgiving turkey pre-order program kicked off on Wednesday, October 7th. The leading grocery store has consistently offered the freshest local and fair priced turkeys for generations and this year will be no different. Get the details:
Continue reading It's Not Too Early to Order Your Locally Raised Thanksgiving Turkey!.


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At the end of last month we, along with just about every other tech news site on the planet, were captivated by the somewhat disasterful (yes, I made that word up) performance of a 3D printer which printed using an aerosol-like can of Easy Cheese. The creation was the brainchild of California College of the Arts (CCA) Hybrid Lab manager Andrew Maxwell-Parish.
Posted on Tuesday, April 14, 2015 by Laura Braun
Posted on Monday, April 13, 2015 by Laura Braun
Time is running out for the inflatable man. His precious seconds ticking upward in large blinking red numbers on an LED screen. Some passers-by stop to take-in the painfully slow demise - unaware that the writhing, thrashing figure with the frowny face is essentially pummeling himself into oblivion.
Posted on Thursday, April 9, 2015 by Laura Braun
The show -- incorporating experimental elements, such as allowing visitors to add their own stories through real-time social media channels -- is basically 10 exhibits in one. It's a collaboration of works by socially minded Oakland-based artists hand-picked by the project's lead artist, Chris Johnson, professor of photography at the California College of the Arts. Through sculpture, video, photography, a murder of fake crows and even elements of journalistic reporting, each artist explores the layers, the complexities, the individuality of the city.
Posted on Thursday, April 9, 2015 by Laura Braun
Last fall, when the Oakland Museum of California approached Chris Johnsonfor ideas on connecting the museum to a broader range of Oakland residents, Johnson was blunt.
Posted on Tuesday, April 7, 2015 by Laura Braun
Andrew Maxwell Parish is a lab manager at California College of the Arts. He's apparently got at thing for Easy Cheese as well: He claims on his website that he's been trying to convince his students to build an Easy Cheese 3D printer for over two years.
Posted on Monday, April 6, 2015 by Laura Braun
Born in 1971 in Santa Monica, CA, Josh Greene has exhibited widely including at the Hammer Museum at UCLA, the Nelson Gallery at UC Davis, San Francisco Arts Commission Gallery, Yerba Buena Center for the Arts, and more. He holds an MFA from the California College of the Arts where he is currently an adjunct professor. Greene works in the conceptual art tradition with a focus on public actions and interchange.
Posted on Thursday, April 2, 2015 by Laura Braun
The experiment comes from the creative mind of Andrew Maxwell-Parish, manager of the Hybrid Lab at the California College of the Arts. Previously, he designed an interactive tip jar called the Wu-Tang Can and a High Five Camera for capturing high fives with strangers.
Posted on Thursday, April 2, 2015 by Laura Braun
Andrew Maxwell-Parish did just that, making our printable processed cheese dreams come true. Maxwell-Parish, manager of California College of the Arts' Hybrid Lab, had his printer give a cracker a healthy amount of cheese, draw some cheese squares, and attempt to build a cheese box.
Posted on Tuesday, March 31, 2015 by Laura Braun
"A lot of this has to do with lamenting simpler times," said Greene, a conceptual artist and adjunct professor at the California College of the Arts. "It's hedging against, or bumping up against the world we live in…but I think some of that goes away a little bit, and it's just about the book and what it means to people."
Posted on Tuesday, March 31, 2015 by Laura Braun
Because squirting cheese product out of a can isn't enough fun, Andrew Maxwell-Parish, the manager of the Hybrid Lab at California College of the Arts, created a robot to do it for you. Unfortunately, the machine is still in development. Watch the hilariously frustrating test run, below.


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Wednesday, October 07, 2015
4 comments
Well, saw the doctor who will be doing my gallbladder surgery today. I'm going to have the surgery on Monday at 8am CST. I have to be there an hour an a half before the surgery and I'm the 2nd person who will be having surgery that day. Its not ... Read more
Tuesday, October 06, 2015
0 comments
Well, I've been coughing and hacking like crazy for a week but been taking an antibiotic since Friday. Its working some but not at night for a while. I also take a OTC cough syrup that the doctor recommends and Vitamin C cough drops. I feel some... Read more
Saturday, September 05, 2015
2 comments
After going to Target to do what our usual thing, we came home for a while before going to a laundry mat to wash clothes since our dryer won't work and our washer won't spin the water out of the clothes. Plus I had to fight the dog to keep her i... Read more
Wednesday, September 02, 2015
0 comments
Finally got an appointment with the regular doctor but it'll be a while until I can go and see him. A week from this coming Monday at 10:15am. There was an opening the next day but that was too early to go in. 8:15am. This is the only time that ... Read more
Tuesday, September 01, 2015
1 comments
Today was a hot day and it is still hot tonight. We don't have a working air conditioner because dad accidently pulled out the wrong circuit breaker when he was trying to pull the one for the dryer (the wall outlet for the dryer isn't working). ... Read more
Sunday, August 23, 2015
5 comments
Went to the lung doctor this past Wednesday. He thinks that I might have sleep apnea. With my short neck, weight, bloated legs, and some chest pains, I might have sleep apnea. Plus there are a few other symptoms like the headaches, shortness of ... Read more
Monday, August 10, 2015
5 comments
Well, since I last posted in here, I have been to the ER at least 3 times and the over the weekend my blood sugar got low. So low that it scared me. The days that I went to the emergency room was July 30th and 31st with dizzy spells. Come to fin... Read more
Friday, July 10, 2015
4 comments
Well, the new medicines are helping. Since Monday, I've lost 4 pounds. It has helped my legs a lot but not much. At least they're not as bloated as they were a week ago. I'm just glad that I'm not taking as much as my dad. Dad takes 60mgs of the... Read more
Wednesday, July 08, 2015
3 comments
I'm taking some new medicines but not for the headaches or shortness of breath. My legs have been bloated since my dad took me to the emergency room back in March and the doctor didn't do anything about it until I mentioned it when I got the res... Read more
Thursday, July 02, 2015
1 comments
I got the results of the PFT test today. The test showed something abnormal but I'm not sure what though. I have to see a lung doctor on August 19th t see what's going on.
Dad had me in the emergency room this past Saturday. I was having t... Read more
Tuesday, June 23, 2015
3 comments
Well I had to call the doctor's office to see about the lung test tomorrow and where its at. I'm having the PFT tomorrow. I also asked about the results of the two tests that I had last week. Both CT Scan on my head and the EKG on my heart came ... Read more
Sunday, June 21, 2015
4 comments
Sorry for the long delay but I've been feeling like crud for the past month. Headaches, chest pains, shortness of breath, numbness, and a few other things. I saw my regular doctor the beginning of the month. He sent me to a cardiologist 11 days ... Read more
Friday, May 15, 2015
1 comments
My dad and I got in about 5 hours go to my brother's house in Ohio. Got to meet the two male cats that him and his wife have. Loki and Bailey. Sweet cats. Sofie (their other cat) is still not coming up to us yet. She came up to me a couple of ho... Read more
Friday, April 17, 2015
1 comments
I'm sorry for the delay but there hasn't been much news coming from here. I have been feeling better since my trip to the emergency room but the weight has been flexing. I've gained the 8 pounds back but I've been slowly losing it. Really slowly... Read more
Sunday, March 22, 2015
5 comments
Well, I'm doing better since my trip to the emergency room. I saw my doctor the day after the stress test. He said that the emergency room didn't mention about my aorta arching but did mention about the fatty liver. He didn't mention that I didn... Read more


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THE LIST, available for 99cents in Kindle format.
In which we meet Miles Bell, His Majesty's spy in post WW1 Switzerland, as he faces Proto-nazi's, murder, betrayal…and dark creatures waiting to swallow England.
(Click through to read a passage from the story)
Continue reading "THE LIST ebook now on sale"


text: This seal walks into a bar. The bartender says, "Hey! You can't come in here unless you're wearing a tie." So the seal goes outside and sees an elephant sitting behind the wheel of a Volkswagon Beetle. He asks the elephant, "'Scuse me buddy, but do you have a tie I could borrow?" The elephant replies, "No, but I've got a set of jumper cables you can use." The seal takes the jumper cables, ties them around his neck, and goes back into the bar. The bartender sees him come in and yells, "Didn't I tell you not to come in here unless you're wearing a tie?" The seal point to the cables around his neck and tells the bartender "This IS my tie." The bartender glares at the seal for a moment, then warns him, "OK, you can come in -- but don't start anything!" Ba-dump-bump.


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Best alternative I have so far is the XX1 - 650g including the BB. £170 at bikediscount.de:
SRAM XX1 Kurbel 1x11-fach 32T QF 168mm GXP
I have a spare Shimano Hollowtech II XT bottom bracket - SM BB70 - can I use this instead of buying a new one for the XX1? (on a Lynskey Pro29 SL)
This should drop 120g when compared to the RaceFace Deus set up I currently have. Although that's only a quarter of a pound...
£170 for 120g - not sure it's worth it...
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Environmental Management Companies in Guinea-Bissau
Category: Environmental Management ×
Subcategory: Environmental Management ×
Industry: Agriculture ×
Location: Africa ×
Location: Guinea-Bissau ×
Quantum Compliance
based in Ann Arbor, MICHIGAN (USA)
Quantum Compliance provides Environmental Health and Safety (EH&S) software solutions that help businesses implement and maintain compliant and sustainable EH&S practices. Our cost-effective modules are available individually or as part of the integrated Q EHS compliance system. Founded in 1985 by a team of environmental engineering and computer science professionals who ...
Maxxam Analytics
based in Mississauga, ONTARIO (CANADA)
Maxxam is the Canadian market leader in analytical services and solutions to the energy, environmental, food and DNA industries and a member of the Bureau Veritas Group of companies – a world leader in testing, inspection and certification services. We support critical decisions made by our customers through the application of rigorous science and the knowledge and ...
based in Leinfelden-Echterdingen, GERMANY
thinkstep is the global leader in sustainability performance management. Our data, drawn from more than 7,000 datasets, is unrivalled in its scope and rigour, and permits precise sustainability calculations across all parts of the supply chain. Our software is robust, convenient to use and available on-demand or as part of a complex, configurable solution. Our services ...
based in AVON Cedex, FRANCE
GEOVARIANCES is a French independent software vendor which provides its customers with the most complete solution in Geostatistics: innovative methodologies, expertise, training, mentoring and software packages to answer their challenges in mapping, volumetric estimation and risk analysis. GEOVARIANCES sectors of expertise are Mining, Oil & Gas, the Environmental field ...
Grundfos Pumps Corporation
based in Bjerringbro, DENMARK
Grundfos is the world`s largest manufacturer of pumps and pump solutions.
Cambridge Environmental Research Consultants (CERC)
based in Cambridge, UNITED KINGDOM
Developers of environmental software including the well known Atmospheric Dispersion Modelling System, ADMS. The world leading ADMS-Urban calculates pollution concentrations at street level resolution over urban areas and links seamlessly to regional air quality models. ADMS 5 for industrial pollution combines state-of-the-art science with an unparalleled range of model ...
based in Englewood, COLORADO (USA)
IHS is the leading source of information and insight in critical areas that shape today's business landscape – including environmental, health, safety and sustainability (EHS&S). Businesses and governments worldwide rely on IHS software, content and expertise to manage a broad spectrum of critical EHS business challenges, including operational risk, product stewardship, ...
Solid Applied Technologies Ltd. (SolidAT)
based in Ashkelon, ISRAEL
Solid Applied Technologies Ltd. (SolidAT) offers level sensors and remote monitoring solutions for level, volume and open channel flow. SolidAT level sensors are non-contact and implement ultrasonic technology. Remote monitoring is based on GPRS cellular communications and a web-based monitoring application. Ultrasonic sensor technology is the best choice for challenging ...
Intelex Technologies Inc.
based in Toronto, ONTARIO (CANADA)
(Intelex Technologies, Inc.) Trusted since 1992, Intelex is a global leader in EHS, Quality and Business Performance Management software. We enable organizations to ensure the highest standard of health, safety and environmental conditions as well as superior product and service quality by streamlining and integrating business data for our more than 1,000 clients and ...
Ecotech Pty Ltd
based in Knoxfield, AUSTRALIA
Ecotech is an Australian owned company with more than 35 years experience in servicing, maintaining, designing, manufacturing, installing and commissioning ambient air and emission monitoring systems around the world. Ecotech is ISO17025 accredited for the operation and maintenance of ambient air and continuous emission monitoring systems and was first accredited in 1999. ...


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By BGEA Staff • June 1, 2004 • Topics: Heaven, Money
God has a special reason and place for each of His created beings. Animals, too, have a purpose in God's creation. Man, as the highest order of creation, has been given dominion over the animal kingdom (Genesis 1:26-28).
We believe that animals were intended for man's enjoyment and use. The Bible itself does not indicate that there is life after death for animals. It may be that God's purpose for animals is fulfilled on this earth. However, if animals would make us happier in heaven, surely there will be a place for them there.
Some Bible interpreters have called attention to Isaiah's description of the peace of God's future kingdom where he says that "the wolf and the lamb will feed together, and the lion will eat straw like the ox" (Isaiah 65:25). Heaven will lack nothing that is good and that will bring glory to God.
Isaiah's prophecy about animals could very well be as a part of "a new heavens and a new Earth" (Isa 65:17), but it is doubtful that in the place called "Heaven", that we would need animals. Consider that Jesus said men and women would not marry in Heaven, but be like the angels. Hence, Heaven appears to be different than any Earthly design. Besides, there are likely to be all sorts of "treasures laid up in Heaven" which would make animals so peripheral as to be of no importance anyway. And in Revelation 21 & 22, the descriptions given speak of a place without natural biology, since God is the light, not the sun, etc, and the trees are of a supernatural type, not biological, and no mention of life other than those who were saved by the blood.


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At Suburban Florida Beach, 'Weeds' for Real
More Americans moved to Florida last year than any other state. One Florida community recently learned that part of its growth has been fueled by drug dealers.
Investigators say that Florida's Treasure Coast has become a hot spot for a new suburban drug problem: marijuana grow houses. Authorities have busted more than 50 grow houses in the Port St. Lucie that were part of an ingenious scheme.
In the region, drug bosses have bought houses for people who wanted to move to the beach community — and were willing to raise pot on contract.
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Native Plants
Q. Who is Mr. Smarty Plants?
A: There are those who suspect Wildflower Center volunteers are the culpable and capable culprits. Yet, others think staff members play some, albeit small, role. You can torture us with your plant questions, but we will never reveal the Green Guru's secret identity.
Did you know you can access the Native Plant Information Network with your web-enabled smartphone?
Ask Mr. Smarty Plants is a free service provided by the staff and volunteers at the Lady Bird Johnson Wildflower Center.
Need help with plant identification, visit the plant identification page.
rate this answer
Thursday - September 10, 2009
From: Stillwater, OK
Region: Southwest
Topic: Deer Resistant
Title: Food for deer and turkey in Oklahoma
Answered by: Nan Hampton
QUESTION:We recently moved to NE Oklahoma from Texas and have 7 acres, a lot of wild turkeys and wild deer. About 2-3 acres are open, with sun and partial to lots of shade as the rest is heavily wooded. What can I plant in the open areas that deer and turkey like?
ANSWER:It is a pleasure to tell someone about plants that deer like, instead of trying to find plants that deer won't eat! Oklahoma Cooperative Extension Service publication, Ecology and Management of Deer in Oklahoma, shows a list of "Some Preferred Native Foods" and Texas Parks and Wildlife has a publication, White-tailed Deer Managment in the Texas Hill Country, that also has a list in Appendix B of favorite deer browse. Here are a few of the suggestions from these lists:
Quercus shumardii (Shumard's oak) and other oaks for their acorns.
Celtis laevigata var. reticulata (netleaf hackberry)
Diospyros virginiana (common persimmon)
Cornus drummondii (roughleaf dogwood)
Cornus florida (flowering dogwood)
Rhus aromatica (fragrant sumac) and Rhus lanceolata (prairie sumac), as well as other sumacs.
Prosopis glandulosa (honey mesquite)
As it turns out, wild turkey like much the same food as deer along with the addition of grasses, especiallly in the Panicum sp. and Paspalum sp. Here are are a few species of these particular grasses that occur in Oklahoma:
Panicum capillare (witchgrass)
Panicum hallii (Hall's panicgrass)
Panicum virgatum (switchgrass)
Paspalum floridanum (Florida paspalum)
You can read more about creating and maintaining habitat for turkeys in the publication from the Texas Department of Parks and Wildlife, Post Oak Savannah and Blackland Prairie Wildlife Management—Wild Turkey.
More Deer Resistant Questions
Deer-resistant plants for Williams, OR
January 24, 2011 - I live in Williams, Oregon. I would like a listing of deer resistant, drought tolerant,evergreen, fast growing, native plants that can be used as a privacy screen on property perimeter.
view the full question and answer
Safely killing Paedeeria cruddasiana Prain (sewer vine)
October 27, 2005 - Is there anyway to safely kill Paederia cruddasiana Prain (sewer vine)? Thank you!
view the full question and answer
Deer resistant plants for Toronto, Ontario
March 02, 2009 - What are the native trees and shrubs that are resistant to deer browsing and rubbing?
view the full question and answer
Deer-proof native plants
May 14, 2007 - Dear Mr. Smarty Plants: Can you recommend some Deer-proof native plants including shrubs and flowering plants?
view the full question and answer
Climbing vines that are deer resistant
July 12, 2013 - Please find plants that are climbing vines and are deer resistant
view the full question and answer
|Support the Wildflower Center by Donating Online or Becoming a Member today.
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El Mirador Quality Stay
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Flanders Fields
... in the rain. Generations of vandals have lead the french to design pedestals with no seat. I was surprised to find that after a reasonably short period of time the porcelain became quite warm and comfortable! Job done, I stood to clear the bowl, only to miss the flush button and hit the launch button. I swear the force of the water drove the contents of the bowl, through the floor and directly in the sewers below! I stood as far back as the cubicle would allow, to avoid ...
Beautiful Bruges
Bruges really is like walking into a fairy tale. It's almost too beautiful to be true, and at times it feels like you are walking around a custom, purpose built wonderland that was purely created for tourism. Yet, there is such a relaxed feel to the place. The canals, bridges, trees, parks, the stepped roofed houses, swans, cobbled streets, horse carriages …… you can't help but be enchanted! Yes it's touristy (almost as touristy as Disneyland!), but somehow ...
Exploring the city of Bruge
... Belgian Waffle Truck and had our daily fix! Then bundled up to go on the city tour. We learned what all the beautiful buildings were, not that we would remember, but it's nice to learn it once! We then took the city bus for a trial run to the train station, real easy. We took a scenic route back to town, oh my goodness, so pretty. The canals, the swans, the horses clip clopping by. We stopped ...
Short weekend but more time for Brugge
... and no obvious styles to get out when we left. fine with us, we like riding 1st class. (later found out we were entitled to because of our ticket class - YEA!)
Bruges is a tourist town. it is not very large and the central part of the city is what all the tourists want to see therefore it is pretty much of a parking lot, everything moves slow because of the segways, the horse and carriages, the city tour buses, and all the pedestrians who ...
... via yet another chocolate cafe (when in Bruges...) saw us reach the apartment about mid-afternoon. Rhi decided to have an afternoon in to escape from the miserable weather but I was feeling pretty energetic and therefore opted to take in a few extra sights. The Basilica of the Holy Blood was another mind boggling moment for me- inside the tabernacle was the relic containing what is believed to be some of Christ's blood that was captured as it spilled from his ...


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How to offset the items in a stacked bar chart for any given bar?
Bar 1: 4 items (150,290,200,50)
Bar 2: only 2 items (--, --, 240,45)
I want to start the item with value 240 at a given offset instead of starting at 0 ( ex: I want to start it at 600 and show 240 from there). From 0 to 600, it will be blank/white space.
I can post my example code if that's of any help.
Thank you.


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Glamorous and functional, this sleek black-and-gold box is crafted of lacquered wood and topped with a piece of Himalayan crystal.
The Chalkboard Bakes: Gluten-Free Chocolate Orange Loaf Cake #glutenfree
The Chalkboard Bakes: Gluten-Free Chocolate Orange Loaf Cake#glutenfree #cake #chocolate
A touch of blue - gorgeous!
Style, Color, Bleu Paradis, Hermè Birkin, Women'S Handbags, Products, Birkin Bleu, Beautiful Handbags, Bags Ladies
Hermès Birkin Bleu Paradis/ of course! to the bag but the Color is IT
This large pouch allows you to store your cosmetics worry-free with its water-resistant lining.
Crafted of glass with a multifaceted exterior and white-and-gold finish, this votive holder is perfect for creating an intimate ambiance.
Jonathan Adler Petal Mirror
Petals Mirror, Wall Decor, Decor Ideas, Adler Petals, Adler Mirror, Abalone Shells, Polish Brass, Modern Home, Jonathan Adler
Jonathan Adler mirror
I love the shape... May have to create something based on this. Modern Home Decor | Petal Mirror | Jonathan Adler
Jonathan Adler Petal Mirror- TDF!!! Made with abalone shell and polished brass
Jerry Hall
70S Fashion, Jerry Hall, Bianca Jagger, 70 S, Style, 70S Glamour, 1970S, Fur, Mick Jagger
This week, we're taking inspiration from icon Bianca Jagger, known for epitomizing the glitz and the glam of the 1970s. Often seen at Studio 54 with ex-husband Mick Jagger or best friend Andy Warhol, she loved to rock a YSL suit and low-cut shirt, or Halston dress accessorized by her signature turban and luxurious furs. Who could forget when she made fashion history, arriving at her 30th birthday party at the famous club on a white horse? Scroll down to see more photos of the Nica beauty.dv.
70s glamour
Jerry Hall showing us how to wear 70's summer furs to dress up the evening pajama #love #style #fashion #flare #icon #houseofauora
jerry hall 70s fashion - Google Search
Launched by former ELLE magazine fashion director Heather Hogan Roberts, Ivy and Vine offers a curated eclectic mix of vintage, refurbished and custom furniture and accessories for the home.
Listen to a heartfelt conversation between supermodel Cindy Crawford and her daughter, Kaia Gerber, as they discuss growing up, social media, and playing dress-up in Cindy's heavenly designer closet.


text: This place has been there for over 60 years that I know. Has old fashion style. Eating counter with stools. Some square tables small place, always hopping.. Have excellent soup. Great coffee. If you want an old fashion place to eat this is the spot. You'll have a good visit.


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A eVols system upgrade is scheduled for Thursday October 8 at 2:00pm HST. eVols will be unavailable for approximately 2 hours during this upgrade. Email email@example.com with any questions.
Now showing items 143-149 of 149
|Water resources development -- Hawaii
|Water Supply -- Hawaii
|Working class - Hawaii
|Working class--Hawaii
|World War (1939-1945)
|World War, 1939-1945--Japanese
|Zip codes -- Hawaii -- Honolulu -- Directories
Now showing items 143-149 of 149


text: Khloe Kardashian: Pregnant by Lamar? by Hilton Hater at January 4, 2014 12:52 pm. Updated at May 30, 2015 9:23 am. Comments Share Tweet Email Wait... is Khloe Kardashian pregnant with Lamar Odom's baby?!? This post-divorce rumor is making the rounds. Edit Delete Follow Khloe Kardashian? Facebook Disqus Star: Khloe Kardashian Tag: Khloe Kardashian Pregnant Related Videos: Khloe Kardashian Videos Related Post: Khloe Kardashian: Pregnant With Lamar Odom's Baby?! Uploaded by: Hilton Hater Uploaded: January 04, 2014 Modified: May 30, 2015 09:23 Duration: 94 seconds


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Originally posted on Fox Sports Arizona | Last updated 5/11/12
TEMPE, Ariz. -- With any big contract in professional sports comes added pressure to perform. The five-year deal Cardinals defensive end Calais Campbell inked Thursday is no exception. Campbell welcomes that pressure, though, and embraces the expected leadership that comes with the Cardinals' commitment. "Pressure is definitely a part of the game, and I think it brings the best out of players," Campbell said. "I like having pressure on me. I think it makes me work even harder. It's easier to work hard." Dressed in what he called his best suit, Campbell addressed the media at Cardinals headquarters Friday, his mother and two siblings watching proudly from the back of the room. The humble 25-year-old spent less than seven minutes behind the microphone addressing his long-term deal worth a reported 55 million, but it was clear in that time that Campbell took another step in his evolution with the Cardinals. Campbell has become part of the organization's core, joining the likes of L...
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« Back
Some examples of why the human race has probably evolved as far as possible. These are actual instruction labels on consumer goods...
On Sears hairdryer: Do not use while sleeping. (Gee, that's the only time I have to work on my hair!)
On a bag of Fritos: You could be a winner! No purchase necessary. Details inside. (The shoplifter special!)
On a bar of Dial soap: Directi ...continue
Set as my Away
♥ I Want a Guy Who Would Move The Hair Away From My Eyes & Then Kiss Me. Hold My Hand In Line At The Mall To Make All The Girls Jealous .. Someone Who Would Sing To Me At RAND0M Moments. Who Would Let Me Sleep On Their Chest .♥ & He Wouldn` Mind If i Ate More Than Him .. Someone Who Would Let Me Gossip To Him .. & Would Just Smile & AGREE With Everything I Said .. No ...continue
Set as my Away
101 Ways to Annoy People 1. Sing the Batman theme incessantly. 2. In the memo field of all your checks, write "for sensual massage." 3. Specify that your drive-through order is "to go." 4. Learn Morse code, and have conversations with friends in public consisting entirely of "Beeeep Bip Bip Beeep Bip..." 5. If you have a glass eye, tap on it occasionally with your pen while talk ...continue
Set as my Away
Today we salute you,
Mr. Backyard Bug Zapper Inventor.
Not content to harmlessly repel insects with lotion,
You discovered a way to fry them with electricity until their bodies explode.
Ah the sounds of summer:
Crickets chirping.
Birds singing.
The blood-curdling scream of a moth having 700 volts of electricity shooting through its body.
(music to my ...continue
Set as my Away
:::Questions not to ask in Foreign Lands::: IRELAND "Are you magically delicious or just angry and drunk? This beer is black- did a leprechaun crap in it?" FRANCE "Can I get a side of Freedom Fries with that? Aren't the French just Germans who can make sauces?" ITALY "Is the Pope Polish? Does he have super powers like Jesus? I could sure go ...continue
Set as my Away
News from BadassBuddy
September 2010
On Sep 24, 2010, BadassBuddy will be 10 years old.
A decade ago BadassBuddy.com went from 0 to Badass in about 2.5 lunar cycles (the Web's 21st fastest growing site at the time), and the birth of an Internet anti-hero turned into a fleeting past-time for millions of chat-zombies around the globe (before SpaceBook took ownership of the majority of our free time). At times BadassBuddy was almost as impressive as the best xkcd ever!, with aspirations of being just half as cool as the worst Homestar Runner ever. (..negatory..)
10 years ago the BadassBuddy concept essentially began with just one simple piece of "edgy" pixel art that made AOL Instant Messenger®© appear to have a nifty new feature:
Unfortunately, pixel art has since been considered a dying art form, however the ninjas over at pixeljoint.com will show you that pixel creativity is in fact still very much alive (and I know you still love retro video gaming when you're not FPS'ing and rocking out with pretend instruments).
So I'd like to wish BadassBuddy a happy 10 year anniversary, but more importantly I'd like to thank the brilliant artists, the mediocre artists (gotta start somewhere), the blog entry contributors, the web designers and content managers, the rockingest server admin ever, and everybody else involved, for all of the hard work and passion that went in to making a unique contribution to the interwebs.
Add this retro-cool BadassBuddy button to your page right now!
Copy and paste the following code into your HTML!


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Bowel movements immediately after eating? Have IBD...
Dear Shannon, My heart goes out to you! It does sound like you're experiencing a...
Posted by
Dear Shannon,
My heart goes out to you! It does sound like you're experiencing a flare, which for me is often triggered during times of mental or emotional stress. It sounds like you are going through a good deal of stress due to being the support for BOTH your husband and your father!! That would be enough stress to put me over the edge and into a full-on flare!!
It sounds like you need to take care of yourself. Just like on the airplane - parents are told to put on their OWN facemasks first before assisting their children because if they pass out they'll be NO HELP whatsoever to their families.
So it is for you, too! You won't be any help to your family members if you're totally self-destructing with an untreated flare! YOU need help if you want to be able to help them!
Also, do you have any support network of friends, family, a yoga group, a church family, a therapist, someone that YOU can rely on to help you to make it through this stressful time. We all perform better when we have someone to lean on.
I hope this is some help to you. Please don't be afraid to ask for help and to get the support that you need to help you to survive your own health problems and those of your family members. None of us can do this alone.
Take care and please take your body's signals seriously. Losing 25 pounds in one month is a BIG signal that you need to listen to! Get the medical support and emotional support that you need. The newest research shows that the mind-body connection is much stronger than anyone ever thought it was. Our digestive system is referred to as our secondary nervous system in the medical community because our emotions can totally dominate our digestive health! When a person is stressed and has no outlet for this stress, it often comes out in Crohn's/Colitis flares! I have a sister who had severe Crohn's disease and ended up having her entire large intestine removed and she had to wear the bag for a year before reconstructive surgery that reconnected her small intestine to her colon. She was on extremely strong steroids for over a year that has now given her osteoporosis! So, take your symptoms seriously, because they can get much worse if you don't. Get exercise, do yoga, do meditation, pray, write a gratitude journal, practice tai chi, do SOMETHING to relieve stress.
WebMD website just had a feature on how research has proven exercise to be just as beneficial as anti-depressants! And with NO side-effects!! Exercise produces endorphines that lift our moods and enable us to feel better and function better in life.
I hope you start feeling better soon.
Mary Martin (an EX-colitis patient!)
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H.Res.1226 - Commending EyeCare America for its work over the last 25 years.111th Congress (2009-2010)
ResolutionHide Overview icon-hide
|Rep. Green, Gene [D-TX-29] (Introduced 03/25/2010)
|House - Energy and Commerce
|Latest Action:
|09/28/2010 Motion to reconsider laid on the table Agreed to without objection.
This bill has the status Passed House
Here are the steps for Status of Legislation:
- Introduced
- Passed House
Subject — Policy Area:
- Health
- View subjects
Cosponsors: H.Res.1226 — 111th Congress (2009-2010)All Bill Information (Except Text)
* = Original cosponsor


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DAYTONA BEACH, FLA. (AP) - NASCAR's marketing machine is already churning.
Shortly after Danica Patrick landed the Daytona 500 pole _ an unprecedented achievement for a female driver _ the president of Daytona International Speedway started making plans to capitalize on the historic story line.
"This week, everybody's going to be talking about Danica and they're going to talk about the Daytona 500, and I will do my best to proliferate that message as well," Joie Chitwood III said Sunday evening.
Chitwood said he sent an e-mail to Fox Sports president Eric Shanks to remind him what it will mean to have the popular Patrick on the pole for "The Great American Race."
"Obviously, from a Fox perspective, it's about viewership," Chitwood said. "For me, it's about publicity for the 500. I think he and I both had a good day today. That's the beauty of sport: you never know what's going to happen. I think we all get excited when you see history. The first woman to ever capture a pole position in Sprint Cup, that's pretty awesome, whether it was Danica or someone else. That was historic, and I'm glad that happened at Daytona."
Chitwood was the president of Indianapolis Motor Speedway in 2005, when Patrick led 19 laps during the Indy 500 and finished fourth. It was the highest finish ever for a female driver in the prestigious event.
"I got to be there for that historic moment," Chitwood said. "Who knows? Maybe I've got a little luck in there. Track presidents, you take that title away, we were always promoters first. Promoting is about publicity and attention and getting people focused on something. This is something that helps us do that. We want every eyeball. We want every consumer showing up. We want everybody coming to the Daytona 500 because it's our biggest event on the schedule."


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Hotels & Lodging in Milford NJ
As you meander through Milford, admiring the bluffs that frame the waterway, make time to stop and sip some hand-crafted beer or wine and sample delicious treats.
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City: Asbury
215 Turkey Hill Rd. Asbury, NJ 08802
Unwind at the Berry Preserve Bed and Breakfast, a tranquil 10-acre woodland retreat. Located off I-78 (Exit 7), these lodging accommodations are between Clinton, NJ and Easton, PA and one hour from...
City: Milford
63 Church St. Milford, NJ 08848
We welcome you to our home, located in the small town of Milford where you'll experience the charm and grace of a century past....
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31 Race St. Frenchtown, NJ 08825
Located in historic and charming Frenchtown, New Jersey, The National Hotel is nestled alongside the Delaware River in Hunterdon County, just across the river from picturesque Bucks County, PA and...
City: Frenchtown
53 Kingwood Ave. Frenchtown, NJ 08825
Romantic getaway. Spend romantic and restful evenings in the Delaware River Village of Frenchtown across from Bucks County and minutes from New Hope PA, Lambertville and Flemington, NJ....
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Gabriel Load Carrier Coil Over Kits combine the benefits of shock and spring technology for heavy duty applications. These feature constant-rate coils that restore ride height and improve stability.
Fits the following Ford F-150 Years
It is in fact possible to have your cake and eat it too. Belltech's adjustable coilover kit gives you upgraded shocks that let you dial in your preferred ride height, compression and rebound rates for a smooth ride or more aggressive racing applications. Belltech, world-renowned for its pioneer status in the custom truck world, designs and manufactures innovative lowering technologies to serve automotive enthusiasts and customizers.
Fits the following Ford F-150 Years
The large-diameter body and stout 5/8-inch NitroCarb piston rod are just a few reasons why the Pro Runner Black Series coil overs are the best Pro Runner shocks available. They're hand-assembled from the highest-quality materials, feature Viton O-rings to prevent fading and are finished in a zinc plating and then clear coated for a dual layer of protection. Pro Comp was built on the premise of developing the best value-based suspension systems and accessories possible for off-road enthusiasts, and is highly regarded as a leading aftermarket manufacturer.
Fits the following Ford F-150 Years
ReadyLift offers these Fox Factory Series coil overs for the off-roader looking for a plusher ride and the ability to turn up the damping for more demanding conditions. Fox's Factory Series coil overs are made with steel bodies and feature billet aluminum components, external reservoirs filled with special race oil and renowned Eibach coil springs. Off-road enthusiasts choose ReadyLift's precision-engineered products to give them the moderate lifts they're after at a price they can afford.
Fits the following Ford F-150 Years
Select more Ford F-150 parts under Shocks, Struts & Components from list below.
Shop Ford F-150 Coil Over Kit Call our auto parts experts at or get an expert recommendation via Live Chat


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Town Square
Safeway's chairman Steve Burd announces his retirement
Original post made on Jan 7, 2013
Read the full story here Web Link posted Thursday, January 3, 2013, 7:44 AM
Comments (2)
a resident of Another Pleasanton neighborhood
on Jan 7, 2013 at 12:06 pm
Safeway getting involved in healthcare....PARTICIPANTS BEWARE!
As an employee, we have to adhere to very strict health guidelines (based on Safeway executives, pharmacist, and third party health ins experts...not from doctors and medical experts) otherwise be penalize and pay a higher fee in insurance, medicine, and clinic-care. Their vision of healthcare is based on a one size fits all matrix/grid/tier that one must fall under in order to get full healthcare benefits. For example if you are a 20 year old heathy person you will get full coverage and lower premium vs a 20 year old who has asthma or birth defect getting partial coverage and pay a higher premium. Also in the works is a rewards points program ( gamification) with other to compete who stay the healthiest . So we compete for a discount on insurance, medicine, and care. Also privacy would be an issue as well with this program.
So bottom line Safeway will only insure the very healthy and penalize/capitalize on the not so healthy.
As a employee, I have to partipate in order to be insured. Stick with the tried and true, like a sound healthcare company...not from a grocery industry turned healthcare!
a resident of Livermore
on Jan 7, 2013 at 12:59 pm
pandy...your explanation is UNSATISFACTORY...you fail!
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