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Massage Therapy Programs – New York
Students in the Massage & Asian Holistic Health programs are immersed in programs that truly embody balance, bringing the best of both Eastern and Western massage. Students study and apply Tui Na, Swedish massage, shiatsu, Thai massage and a host of other styles. Biomedical courses help prepare practitioners for both medical and spa settings and allow them to fully understand how massage techniques affect the body on a physical level.
As an intern in the clinic, you will work as part of a holistic medical team, comprised of massage practitioners, licensed acupuncturists, supervisors and fellow students. The clinical experience gives you the practical, hands-on experience you need to make a smooth transition into a professional clinic.
Associate of Occupational Studies in Massage Therapies, AOS
Pacific College's Associate of Occupational Studies in Massage Therapies program develops students into expertly trained body therapists. This degree in massage therapy integrates Asian and Western bodywork therapy, including topics such as anatomy, physiology, general pathology, kinesiology, and Eastern and Western massage.

subset: commoncrawl


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Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://olabout.wiley.com/WileyCDA/Section/id-817008.html
Letters: New Observations
You have full text access to this OnlineOpen article
Ropinirole monotherapy induced severe reversible dyskinesias in Parkinson's disease†
Article first published online: 5 FEB 2013
DOI: 10.1002/mds.25318
Copyright © 2013 Movement Disorder Society
Movement Disorders
Volume 28, Issue 8, pages 1159–1160, July 2013
Additional Information
How to Cite
Batla, A., Stamelou, M., Mencacci, N., Schapira, A. H. and Bhatia, K. P. (2013), Ropinirole monotherapy induced severe reversible dyskinesias in Parkinson's disease. Mov. Disord., 28: 1159–1160. doi: 10.1002/mds.25318
- †
Relevant conflicts of interest/financial disclosures: Nothing to report.
Full financial disclosures and author roles may be found in the online version of this article.
Publication History
- Issue published online: 12 AUG 2013
- Article first published online: 5 FEB 2013
- Manuscript Accepted: 15 NOV 2012
- Manuscript Revised: 6 NOV 2012
- Manuscript Received: 11 SEP 2012
Cited in:
- CrossRef
This article has been cited by:
- 1Ropinirole, Reactions Weekly, 2013, 1468, 1, 35


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Rated 4.6 out of 5 by 321 reviewers.
Rated 4 out of 5 by Goose counter stools Stool is very nice, heavy, no tipping over. It is just a little too short for counter height. September 4, 2010
Rated 4 out of 5 by Karboo Counter height looks different I ordered 8 COUNTER HEIGHT stools. They were a bit of a shock right out of the box because the legs are so short compared with the picture (which shows the more elegant and proportional bar height). The leg on the counter height is the same length as the height of the chair back...which makes the chair back look too big and the leg too short. I thought they looked strange until we put them up to the counter and then they just looked super! The leather is soft and the nailheads are real. Some of the details on the woodwork are rustic (not crisp and perfect compared to high end furniture lines) but overall, super pretty and a great value. Thumbs up! September 3, 2010
Rated 4 out of 5 by Mo Nice looking bar stools good quality for the $. Nice looking bar stools. Good quality for the money. Well packed in the shipping process. September 3, 2010
Rated 4 out of 5 by gigi Bar Stools Although we had to wait for them for a long time, they are beautiful and were easy to assemble. They are a great value. The fact that they look great and swivel make them very versatile and the style blends with the decor of many different types of rooms. September 2, 2010
Rated 4 out of 5 by LOLA Manchester Swivel bar stool We love the leather and the detail. However six out of seven chairs are uneven causing them to wobble a little. They are beautiful or I would return them. Frontgate did ask if I wanted to replace them. August 26, 2010
Rated 4 out of 5 by Susi-Q Manchester Bar Stools Stools are as represented. Did have a few scratches that need touching up at seams of seat. August 25, 2010
Rated 4 out of 5 by Amy Manchester Stools I am very pleased with the barstool. They are well made and beautiful. My only request is that you include a furniture marker with the purchase, because by the very design of the stool you know that they are going to get hit where they swivel into the bar and get marked up. We have one mark already and less are about 2 weeks old and we are a careful family. August 17, 2010
Rated 4 out of 5 by Julie New to Front Gate Love these bar stools. They are very comfortable and look great with my new slate floors. I am very happy with the craftsmanship and they were worth the backorder status. August 16, 2010
Rated 4 out of 5 by mark beautiful and functional bar stools very good quality, beautiful to look at, good tosit in July 30, 2010
Rated 4 out of 5 by Waltz Great for price Beautiful wood and leather. Only issue was one of the barstools had a hole for a screw that didn't line up with the space. So, we just left it as is. I didn't want to go through the trouble of returning it. May 24, 2010
Rated 4 out of 5 by Lancelot Lovely Bar Stools The product was wonderful and just as promised. I would recommend them to anyone interested in regal bar stools. However I was NOT happy to open a catalogue a few days later and find them $200.00 cheaper. This put a very bad taste in my mouth. May 18, 2010
Rated 4 out of 5 by 619ed Great Price I just receive my barstools, they look good and the feel of the leather is great. The manufacture could do a better job in there QC department other than that great barstool. May 18, 2010
Rated 4 out of 5 by Beth A Luxurious Addition Loved everything about these stools. I have been comparing quality and prices for two years before I purchased these, both in stores and online. I could not be more pleased with the quality, price, and delivery. Thank you, Frontgate! (kids love them too) May 17, 2010
Rated 4 out of 5 by Nonnie counter stools too low I love our 4 stools. They are beautifully designed. The two counter stools were too short so my husband had to put a spacer where the seat attaches to the legs. It leaves a one inch space that is noticeable from a distance. The bar stools were the right height. Other than that, I've had nice compliments on them. May 11, 2010
Rated 4 out of 5 by Stiffpeaks Good value I ordered three stools. Assembly was easy, but there was a large mess from loose styrofoam pieces that had a static charge on them. I assembled the chairs in the house - suggest you do it outside. One chair arrived with 2 defects (cracked pieces) that should have been detected before shipment. Frontgate arranged for a pick up the next day and scheduled delivery for the replacement. May 11, 2010
Rated 4 out of 5 Good looking barstools These barstools look great at our kitchen counter! If I could suggest one improvement it is to enhance the cushioning on the seat - either make it firmer or deeper. I sit on the stool for long periods of time working, and after a while start to notice the frame of the seat through the cushioning. April 11, 2010
Rated 4 out of 5 by JOHNNIE BEAUTIFUL BAR STOOLS THE BAR STOOLS ARRIVED ONE WITH A SLIGHT DEFECT ON THE LEATHER SEATING SURFACE, AS IF IT WAS TOUCHED UP AT THE FACTORY. THE OTHER IS FINE. ALL IN ALL THEY ARE VERY LOVELY. February 27, 2010
Rated 4 out of 5 by cndree My only disappointment is that the back has a block that protrudes. It is obvious when I touch the back of the seat. The assembley was extremely easy. No scratches or dings. November 19, 2009
Rated 3 out of 5 by GVABCH Looks Great...Seat padding is disappointing We've owned the Manchester Swivel bar stools for a couple of years. However, the padding in the seats is average at best. After using them occassionally for a couple of years the padding has shifted and it feels like you are sitting directly on the wood. I wish could rate them higher because they do look so nice. But, the padding just does not live up to the quality of the rest of the chair. October 13, 2013
Rated 3 out of 5 by kathy1 manchester bar stools These bar stools look awesome. One of two of the stools developed symmetrical cracks in the wood on the lower back of the swivel seat within two days of assembly. Awaiting replacement. September 6, 2011
Rated 3 out of 5 by Laura Frontgate's guarantee is outstanding I ordered 2 bar stools and was very happy with one and very unhappy with the other. The first reject had a wrinkle on the back leather. I called customer service and they sent UPS to pick it up...but I had to get it back into the box which was not an easy task. The replacement came and there was a long gash on the leather. Again, UPS came and picked it up and the third chair arrived. It is beautiful and I am ultimately a happy customer. However, wrestling those chairs was not fun. However, I have nothing but good things to say about Frontgate's Customer Service Dept. January 6, 2011
Rated 3 out of 5 by mark bulky stool The stools are bit bulky. One stool is not level. I am a bit disappointed. September 3, 2010
Rated 3 out of 5 had to return twice i ordered six of these stools. one arrived with a broken leg, another had a knotty piece of wood that was cracked underneath and a third had creases in the leather upholstery and the back padding was poorly done. August 26, 2010
Rated 3 out of 5 by danu nice but not perfect one of the bar stools has the foam from the seat sticking out. August 25, 2010
Rated 3 out of 5 by Fazz Bar chairs Chairs are reasonable priced a good valve. I was disappointed that when they were on sale they did not mention that they were already. Backordered. August 14, 2010
Rated 3 out of 5 by lrmppt Manchester Swivel Bar Stool Padding Great looking bar stools, however the padding on the bottom needs to be thicker. We can actually feel the boards through the seat (no we don't weigh 250 lbs). May 26, 2010
Rated 3 out of 5 by nader Review of the BAr stools The Bar stools do not rotate completely, the screws that have come with the bard stools are too long and hit the screw head of the swivel section. these screws have to get shortened. May 18, 2010
Rated 3 out of 5 by Santa Monica Great looking but... The stools look as good in person as they do in the pictures. The detail is great. The two downsides to me are 1) the seat cushions are thin and cheap and you can feel the wood under your butt - so not very comfortable, and 2) the swivel only moves about 120 degrees and the spring return is pretty strong so you can't actualy swivel to a different position and stay there without a lot of effort. I wish they had a real 360 degree swivel as in my view that's the whole point of having a swivel. May 17, 2010
Rated 3 out of 5 by cleo Okay but not great I purchased the counter height version and this is a good looking stool. All 4 stools were packed well, they arrived in good condition, and they were very easy to assemble. However, I was disappointed in two areas: 1) The height of the seat is about 22 and 1/4 inches, which is shorter than advertised, and 2) The seat is very firm and not as comfortable as I had expected. April 1, 2010
Rated 3 out of 5 by PJ disappointed I purchased 4 of the Manchester Bar Stool. They are very nice made, heavy duty stools, but I was disappointed in what they looked like. I felt like the picture on line did not represent the bar stool. I thought the leather was brown, when in fact its very burgundy. Big disapointment for me. It looks like there is gold rub over the dark wood, which was appealing to me, but the stool has no gold whatsoever, they are just very dark. I snapped a picture of the stools in my home and pasted it next to your on line stool and then forwareded to your customer service dept to show the difference. February 22, 2010
(31 Questions : 32 Answers)
Product Q&A
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Manchester Swivel Bar Height Bar Stool (30"H seat)
0 answers
Does the Mahogany Manchester Bar stool have any RED in the wood.
Additional information about OliviaTX could not be loaded.
Wanted to know if the Mahogany wood on the Manchester Swivel Bar stool have any RED hues in it? Can anyone help me. Thanks
4 days ago
Additional information about OliviaTX could not be loaded.
0out of 0found this question helpful.
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Manchester Swivel Counter Height Bar Stool (24"H seat)
1 answer
May I buy this stool in grey leather seat ?
Additional information about Thao could not be loaded.
My kitchen is in pale blue color so the brown color seat is not macth
6 days ago
Additional information about Thao could not be loaded.
0out of 0found this question helpful.
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Answer:Thank you for your interest in the Manchester Swivel Counter Height Bar Stool. The only leather available for this stool is the shown brown leather. We sincerely apologize for any inconvenience this may cause.
1 day ago
0out of 0found this answer helpful.
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Manchester Swivel Bar Height Bar Stool (30"H seat)
1 answer
Skaneateles, NY 13152, USA
Additional information about MirbeauGM could not be loaded.
What is the width of the seat
2 months, 2 weeks ago
Skaneateles, NY 13152, USA
Additional information about MirbeauGM could not be loaded.
0out of 0found this question helpful.
Was this helpful?helpful0unhelpful0https://answers.frontgate.com/answers/0005/product/35186_BAR/question/1547219/undohelpfulness.djs?format=embeddedhtml&sessionparams=__BVSESSIONPARAMS__&return=__RETURN__&innerreturn=https%3A%2F%2Fanswers.frontgate.com%2Fanswers%2F0005%2Fproduct%2F35186_BAR%2Fquestions.djs%3Fformat%3Dembeddedhtml%26scrolltotop%3Dtrue%26expandquestion%3D1547219&user=__USERID__&authsourcetype=__AUTHTYPE__&submissionparams=__BVSUBMISSIONPARAMETERS__&submissionurl=__BVSUBMISSIONURL__
Answer:Thank you for your interest in the Manchester Swivel Bar Stool. The seat of this stool is 20 3/8" wide.
2 months, 1 week ago
0out of 0found this answer helpful.
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Manchester Swivel Bar Height Bar Stool (30"H seat)
1 answer
Manchester Linen Bar Stool; can this lovely fabric be sprayed with a scotch guard protector?
Additional information about linen could not be loaded.
And another question? Do these bar stools not have dye lots or receiving lots? I have received 3 that match and one that is very different-much lighter? I am working with customer service to replace-but with no guarantee that the one shipped will match the 3 that I have. Thank you in advance for your respone.
Length of Ownership: < 1 year
3 months, 2 weeks ago
Additional information about linen could not be loaded.
0out of 0found this question helpful.
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Answer:Thank you for your interest in the Manchester Swivel Bar Height Bar Stool. You may put fabric protector on these stools. After you've cleaned your upholstery, spray on a stain guard to keep the tougher, harder to cleans stains out. Make sure you get a stain guard that will be effective on your type of fabric. Before using any chemical cleaning solutions or bleach, make sure you test it on a small patch of fabric first. If there's any discoloring, you know to try something else.
Our stools do have dye lots, but there was an error causing a lighter color which has been resolved.
3 months, 1 week ago
0out of 0found this answer helpful.
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Manchester Swivel Bar Height Bar Stool (30"H seat)
1 answer
Any special cleaning guide or cleaning products for linen counter stools?
Cherry Hill, NJ, USA
Additional information about Bigred10 could not be loaded.
Length of Ownership: < 1 year
5 months, 2 weeks ago
Cherry Hill, NJ, USA
Additional information about Bigred10 could not be loaded.
0out of 0found this question helpful.
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Answer:Thank you for you interest in the Manchester Swivel Bar Height Bar Stool. This item in linen fabric should be spot cleaned with linen safe cleaners or professionally cleaned.
5 months ago
1out of 1found this answer helpful.
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Product:35186_BAR-Manchester Swivel Bar and Counter Stools


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Crank is a 2006 American black comedy/action film written and directed by Mark Neveldine and Brian Taylor and starring Jason Statham, Amy Smart and Jose Pablo Cantillo. The plot centers on a British hitman in Los Angeles named Chev Chelios who is poisoned and must keep his adrenaline flowing constantly in order to keep himself alive. He does so by various methods including taking drugs and getting into fights, while he tries to track down the man who poisoned him. The title of the film comes from the slang word for methamphetamine.
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Download PDF Version | Not seeing the puzzle? Click here to download the plug in.
May 16, 2013
Download PDF Version | Not seeing the puzzle? Click here to download the plug in.
I am typically impressed by the creativity of constructors whose puzzles appear in the WSJ, NYT, etc. But one of the least challenging ways to develop a puzzle theme is an anagram approach like this. I don't mind an easier-than-usual puzzle, but when it's so easy and at the same time so unimpressively creative as this one, I wish I hadn't invested the minutes it took to solve it. (And I'm a huge baseball fan.)
Thanks JAB71 and Homer. Little did I know how much time I have wasted and not knowing what it was called!
Nice relaxing puzzle...Homer's comments were absolutely perfect.
Am a big baseball fan and got the theme early but still puzzled a little on a few theme clues
:98A and 114A were very clever!
WSJ Puzzles is the online home for America's most elegant, adventurous, and addictive crosswords and other word games. Try your hand at our daily crossword Monday to Friday, from a roster of the nation's best constructors. The Friday crossword features a contest: a "puzzle within a puzzle" for you to solve (usually a single word or phrase such as a celebrity's name, a country, or a movie title).
On Saturday you'll find a large weekend-size crossword, plus a second specialty word puzzle, drawn from a rotating assortment of cryptics, acrostics and puzzles with ingenious new shapes, from master creators Emily Cox, Henry Rathvon, Patrick Berry, and Mike Shenk. In addition, you'll find a weekly math game created by the National Museum of Mathematics.
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Jim Cramer speaks to Dr. Topol, a cardiologist that could revolutionize the future of medicine through the use of technology.» Read More
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Until last fall we were a nation that shopped until we dropped. Will back-to-school shopping season be a catalyst to get shoppers off the sidelines? An annual survey released today by Deloitte suggests the answer is yes.
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Monthly chain store sales came out this morning. See which companies did well and which did not...
Gregory Wasson, Walgreen president and CEO says the shifting sands in healthcare is creating strategic opportunities for his company.
Forget what the charts say. There are more savory stocks to be had.
Following are the day's biggest winners and losers. Find out why shares of Coach and Wal-Mart popped while Bank Of America and Joy Global dropped.
The stock market's losing streak continued Monday, with Wall Street suffering an across-the-board slump that had some worrying about a long summer for investors.
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Futures indicated a lower start to the week for Wall Street Monday as investors fretted over the global economic outlook after the World Bank cut its 2009 forecasts for most economies.
Cramer makes the call on viewers' favorite stocks.
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First, retailers enticed struggling consumers with deep discounts. Then they dangled buy-one-get-one free deals. The latest recession tactic? Guaranteed financial help in the event of a job loss.
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More companies like Ford, GM and JetBlue are throwing a lifeline to laid off customers with refunds or payment protection.
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Cramer makes the call on viewers' favorite stocks.
The pace of corporate layoffs picked up sharply in January 2009, reflecting the worsening US recession.


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Cape May Hotel Deals and Vacation Packages
Reserve Your Exit Zero International Fall Jazz Festival 2015 Packages Now!
The year's event proudly spotlights the 2015 Marian Anderson award recipient Wynton Marsalis. Wynton, a jazz and classical musician, composer
and arts advocate, is also a past recipient of a Grammy Award, Pulitzer Prize and the National Medal of Arts.
2 & 3 Day Fall Jazz Festival 2015 Packages include:*
- 2 or 3 Night Deluxe Hotel Accommodations
- Guaranteed 1pm Late Check-Out
- The Exit Zero Jazz Festival All Event Dukes Pass :
- Reserved Orchestra Center Seat for Terri Lyne Carrington's Mosaic Project, 8:00pm, Friday, November 6, 2015.
- Reserved Orchestra Center Seat for Jazz at Lincoln Center with Wynton Marsalis, Sat., November 7, 2015, (Based on availability at the time of your purchase, you will have your choice of 6pm or 9pm performances)
- Priority Seating at Cape May Convention Hall performances
- First come-first served entry into all Festival Club Venues
* One (1)All Events Dukes Passpurchase required, per registered hotel guest. After purchasing a Fall Jazz Festival 2015 Package, all guests must confirm seating and show venues by calling Exit Zero at 609.849.9202. All other passes & individual tickets may be purchased at exit0jazzfest.com or by calling Exit Zero at 609.849.9202.
Terms & Conditions:
The All Event Dukes Pass requires payment in full at the time of reservation.
All Event Dukes Pass cancellation policy: All passes are 100% non-refundable.
Hotel accommodation cancellation policy: Deposits are refunded less a 25% cancellation fee if cancelled 14 days or more prior to arrival. Cancellations during the last 14 days prior to arrival will result in forfeiture of your full deposit. There are no exceptions to this cancellation policy. Rooms and rates are subject to availability. All guests must confirm seating and show venues by calling Exit Zero at 609.849.9202
To reserve your package click here
On October 18th join us to experience TEDxCapeMay.
The 2015 theme explores the "Truth Be Told" through outstanding and innovative presenters from a wide variety of fields. The event will take place at the Paul Schmidtchen Theater, located at the Lower Cape May Regional High School, from 9:30am to 5:00pm.
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Details: Limited rooms and room types are available for this promotion. Credit will not be given for any unused reservation and cannot be used for any future purchase. Rate is based on double occupancy and standard room accommodations.


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Networking Classes in Chicago
Most of us have a love hate relationship to networking.
This class will explore a method that doubled my network in approximately two months. Best part of all? It was pretty painless.
If you are a business owner looking for new clients, a business development person, or nonprofit development person, this class is for you! We'll start with a general overview of the method, a guided workshop, and end in somewhat of a speed networking session to practice the method.
In the end you will walk out, not only with a ton of new contacts from the class, but with a whole new philosophy on how to approach networking and a step-by-step method to put it into practice immediately.
This method is not my own, I was lucky enough to have been in a pilot program which will be released online over the next couple of months. Details on that to come!
100% of the proceeds of this class will go to Dabble, BTW.
Want to see more but not ready to sign up? Enter your email below to take a peek at upcoming classes and we'll keep you informed on other Dabble classes. Dabbling never looked so good!Already registered? Log in.
Jayme is the co-owner of a video company and began networking with very few business contacts. In a short amount of time, she was able to grow her network of hundreds of quality targeted contacts and can attribute most of her company's new business to networking.


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Joined on Jul 23, 2012
|Total: 1, showing: 1 – 1
On Sony Cyber-shot DSC-RX100 IV First Impressions Review preview (1567 comments in total)
In reply to:
megafolie: Who cares about 4K. How many here have a 4K tv at home. Even then, true 4k content is nearly non-existent. Finally, the difference between 1080P and 4K on a 40" or 50" display is not that visible to the normal human being.
That said, nice camera.
Right! Because when everyone record their precious family moments with your camera. You just going to delete those videos fairly quickly instead of keeping them till you are old and watching them on your 64K TVs. Who cares about those past videos right? You just care about it right now.
|Total: 1, showing: 1 – 1


text: 10.3886/ICPSR08576.v1 ABC News The Washington Post ABC News/Washington Post Poll, March 1986 Inter-university Consortium for Political and Social Research 1988 civil rights movement drug legislation foreign aid foreign policy health care health insurance marijuana national security Nicaragua presidency presidential performance public approval public opinion Reagan Administration (1981-1989) Reagan, Ronald religion religious behavior Soviet Union unemployment values voter history 1988-06-01 2008-01-29 1986-03-20 survey data 8576 1 This survey includes questions on a variety of political and social issues with an emphasis on two major topics, religion and Nicaragua. Respondents were asked whether the United States should be involved in Nicaragua, whether the situation in Nicaragua is a threat to the security of the United States, and if they approve of the action of the House of Representatives in refusing Reagan's aid request for the contras. On religion, respondents were questioned about religious upbringing and education, current participation, and religion's influence on their personal values. Respondents were also asked to rate Reagan's performance as president and to assess whether or not the Soviet Union is a threat to the United States. Additional subjects include legalization of marijuana, the civil rights movement, medical care and insurance, voting history, day care, and experience with unemployment. Demographic characteristics were also recorded.


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Page 1
Basic Helix-loop-Helix Transcription Factor NEUROG1 and
Schizophrenia: Effects on Illness Susceptibility, MRI Brain
Morphometry and Cognitive Abilities
Beng-Choon Ho, MRCPsych1, Eric Epping, M.D.Ph.D1, Kai Wang, Ph.D2, Nancy C.
Andreasen, M.D.Ph.D1, Amy Librant, B.S1, and Thomas H. Wassink, M.D1
1 Department of Psychiatry, University of Iowa Carver College of Medicine
2 Department of Biostatistics, University of Iowa College of Public Health Iowa City, Iowa, USA
Transcription factors, including the basic helix-loop-helix (bHLH) family, regulate numerous genes
and play vital roles in controlling gene expression. Consequently, transcription factor mutations can
lead to phenotypic pleiotropy, and may be a candidate mechanism underlying the complex genetics
and heterogeneous phenotype of schizophrenia. Neurogenin1 (NEUROG1; a.k.a. Ngn1 or
Neurod3), a bHLH transcription factor encoded on a known schizophrenia linkage region in 5q31.1,
induces glutamatergic and suppresses GABAergic neuronal differentiation during embryonic
neurodevelopment. The goal of this study is to investigate NEUROG1 effects on schizophrenia risk
and on phenotypic features of schizophrenia. We tested 392 patients with schizophrenia or
schizoaffective disorder and 226 healthy normal volunteers for association with NEUROG1. Major
alleles on two NEUROG1-associated SNPs (rs2344484-C-allele and rs8192558-G-allele) were
significantly more prevalent among patients (p≤.0018). Approximately 80% of the sample also
underwent high-resolution, multi-spectral magnetic resonance brain imaging and standardized
neuropsychological assessment. There were significant rs2344484 genotype main effects on total
cerebral gray matter (GM) and temporal GM volumes (p≤.05). C-allele-carrier patients and healthy
volunteers had smaller total cerebral GM and temporal GM volumes than their respective T-
homozygous counterparts. rs2344484-C-allele was further associated with generalized cognitive
deficits among schizophrenia patients but not in healthy volunteers. Our findings replicate previous
association between NEUROG1 and schizophrenia. More importantly, this is the first study to
examine brain morphological and neurocognitive correlates of NEUROG1. rs2344484-C-allele may
affect NEUROG1's role in transcription regulation such that brain morphology and cognitive abilities
are altered resulting in increased susceptibility to develop schizophrenia.
candidate gene; endophenotype; MRI; cognition; schizophrenia; neurogenin
Schizophrenia is a neuropsychiatric syndrome defined clinically by a varied constellation of
signs and symptoms, including hallucinations, delusions, diminished affect, decreased
motivation, emotional impoverishment, and disorganized thought processes and behaviors.
Address for correspondence: Dr. Beng-Choon Ho, Department of Psychiatry, W278 GH, University of Iowa Carver College of Medicine,
200 Hawkins Drive, Iowa City, IA 52242, Phone: 319/384-9299, Fax: 319/353-8656, Email: email@example.com.
NIH Public Access
Author Manuscript
Schizophr Res. Author manuscript; available in PMC 2009 December 1.
Published in final edited form as:
Schizophr Res. 2008 December ; 106(2-3): 192–199. doi:10.1016/j.schres.2008.08.009.
NIH-PA Author Manuscript
NIH-PA Author Manuscript
NIH-PA Author Manuscript
Page 2
Underlying the heterogeneous clinical manifestations are disease-related traits of diffuse brain
volumetric deficits (Honea et al. 2005; Shenton et al. 2001; Steen et al. 2006; Vita et al.
2006; Wright et al. 2000) and generalized cognitive deficits involving multiple cognitive
domains (Blanchard and Neale 1994; Heinrichs and Zakzanis 1998; Mohamed et al. 1999;
Taylor and Abrams 1984).
Genetic epidemiological research indicates that schizophrenia is largely heritable (Sullivan et
al. 2003). Genome-wide linkage studies have identified chromosomal regions harboring
potential disease genes (Owen et al. 2004) from which follow-up fine mapping has implicated
putative susceptibility genes (e.g.(Brzustowicz et al. 2004; Chumakov et al. 2002; Fanous et
al. 2007; Schwab et al. 2003; Stefansson et al. 2002)). Most agree that schizophrenia is
genetically complex. Common alleles each with minor effects are thought to interact together
to manifest the disorder (i.e. 'common disease-common variants' hypothesis). As with other
complex genetic disorders (Botstein and Risch 2003; Goldstein et al. 2003), schizophrenia
likely involves allelic heterogeneity (different disease-causing mutations within the same gene)
and/or locus heterogeneity (different disease-causing mutations in different genes). Other
molecular genetic mechanisms (such as dynamic mutations/expanding trinucleotide repeats,
genomic imprinting, mitochondrial inheritance, deletion/insertions of variable repetitions of
DNA stretches) may also explain the complex, non-Mendelian pattern of inheritance and
phenotypic heterogeneity of schizophrenia. However, whether alternate genetic hypotheses
(e.g. (McClellan et al. 2007; Walsh et al. 2008; Xu et al. 2008)) to the 'common disease-
common variant' assumption are plausible remains a topic of much debate (Craddock et al.
In this study, we examined whether a ubiquitous transcription factor (Neurogenin 1
(NEUROG1 a.k.a. Ngn1 or Neurod3)) may confer increased risk for schizophrenia, and how
NEUROG1 genetic variations may be related to brain volume deficits and cognitive impairment
in schizophrenia. Although gene expression can be controlled at multiple stages (histone
acetylation, gene methylation, initiation of transcription, processing of transcript, transport to
the cytoplasm, translation of mRNA, mRNA stability, or protein stability), the majority of
regulatory events occur at the initiation of gene transcription (Mitchell and Tjian 1989).
Transcription factors regulate the initiation and level of gene transcription by binding to a wide
variety of cis-acting DNA elements. Because transcription factors control the expression of
many genes required in transcriptional regulation, mutations in transcription factors have led
to disorders and consequent phenotypic pleiotropy (Latchman 1996). Thus, genetic variations
associated with transcription factors may be another mechanism underlying the complex
genetics and heterogeneous phenotypic manifestations of schizophrenia.
NEUROG1 is located on Chr 5q31, a region previously implicated in multiple schizophrenia
linkage studies (Kendler et al. 2000; Schwab et al. 1997; Skol et al. 2003; Zaharieva et al.
2008). A recent linkage study found strong evidence that quantitative trait loci within the 5q
region influence abstraction/mental flexibility, as well as nominal evidence for linkage to a
variety of cognitive domains and to schizophrenia liability (Almasy et al. 2008). NEUROG1
gene itself was recently tested for association (Fanous et al. 2007). The major alleles of
rs8192558 and rs2344484 were found to be over-transmitted to schizophrenia patients. We,
therefore, sought to replicate this association. In this study, we further investigated the
relationships between NEUROG1 with MRI brain morphometry and with neurocognition in a
large cohort of schizophrenia patients and healthy normal volunteers.
Ho et al. Page 2
Schizophr Res. Author manuscript; available in PMC 2009 December 1.
NIH-PA Author Manuscript
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Experimental/Materials and Methods
Three hundred and ninety-two patients with schizophrenia-spectrum disorders and 226 healthy
normal volunteers (HNV) were obtained through the University of Iowa Mental Health Clinical
Research Center (MHCRC). These subjects participated in various MHCRC research studies
approved by the University of Iowa institution review board. All subjects gave written informed
consent to undergo research assessments, and provided blood for DNA analyses. Out of these
618 subjects, approximately 80% of them also had magnetic resonance (MR) brain
morphometric imaging and standardized neuropsychological test data.
Patients were evaluated using a semi structured interview instrument, Comprehensive
Assessment of Symptoms and History (CASH) (Andreasen et al. 1992), from which
schizophrenia (N=363) or schizoaffective disorder (N=29) diagnoses meeting DSM-III-R or
DSM-IV criteria were based. HNV were recruited from the community through newspaper
advertisements. They were initially screened by telephone, and further evaluated using an
abbreviated version of the CASH to exclude subjects with current or past medical, neurological
or psychiatric illnesses, or with family history of schizophrenia in first-degree relatives.
Patients and HNV were of comparable age (Mean=28.6 (SD=10.3) and 27.7 years (SD=8.1)
respectively; T=1.05, df=616, p=0.29) and ethnicity (90.3% and 92.9% Caucasians
respectively; χ2=1.23, p=0.26). A significantly greater proportion of patients were male (73.7%
versus 56.1% in HNV; χ2=20.1, p<0.0001).
Genetic Analyses
DNA was prepared by high-salt extraction from whole blood (Lahiri and Nurnberger 1991).
1ng/ul DNA was amplified using ABI (Applied Biosystems, Foster City, CA) 2720
thermocyclers, ABI Taqman®SNP Genotyping 5′ nuclease assays and ABI Taqman® universal
PCR Master Mix. The Taqman®assays consisted of fluorescently labeled VIC and FAM 5′ to
3′ MGB probes and unlabelled forward and reverse primers. Alleles on NEUROG1 SNPs
rs2344484 and rs8192558 were called using ABI Prism 7900 end point read allelic
discrimination software. Replicate samples were included on all genotyping plates to ensure
accurate allele calling.
MRI Acquisition and Image Processing
Approximately 80% (173 HNV and 319 patients) of subjects who provided blood samples for
DNA analyses also underwent magnetic resonance (MR) brain scans. High-resolution brain
anatomical MR data in this study were collected from one of two imaging protocols.
Scans performed prior to calendar year 2000 (termed 'MR5') were obtained on a 1.5-Tesla GE
(General Electric Medical Systems, Milwaukee, Wisconsin) Signa MR scanner. For MR5
imaging protocol, three-dimensional T1-weighted images were acquired in the coronal plane
using a spoiled GRASS sequence (SPGR). The parameters were: echo time (TE)=5ms,
repetition time (TR)=24ms, numbers of excitations (NEX)=2, rotation angle=45 degrees, field
of view (FOV)=26×24×18.8 cm, and a matrix of 256×192×124. Two-dimensional PD and T2
sequences were acquired as follows: 3.0 or 4.0 mm thick coronal slices, TR=3000ms, TE=36ms
(for PD) and 96ms (for T2), NEX=1, FOV=26×26 cm, matrix=256×192.
Scans obtained in 2000 or later (termed 'MR6') were obtained on a 1.5 T GE CVMRi scanner
using T1- and T2-weighted sequences. For MR6 imaging protocol, the T1 sequence was
obtained as a 3D volume in the coronal plane using a SPGR with the following parameters:
TE=6 ms, TR=20 ms, flip angle=30°, FOV=160×160×192 mm, matrix = 256×256×124,
Ho et al.Page 3
Schizophr Res. Author manuscript; available in PMC 2009 December 1.
NIH-PA Author Manuscript
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Page 4
NEX=2. The MR6 T2 images were acquired using a 2D fast spin-echo sequence in the coronal
plane. The parameters were: TE=85 ms, TR=4800 ms, slice thickness/gap=1.8/0.0 mm,
FOV=160×160 mm, matrix=256×256, NEX=3, number of echoes=8, number of slices=124.
Of the 492 subjects with brain morphometric MRI data, there were 232 MR5 scans and 260
MR6 scans. The frequency distributions of patients and HNV across scanning protocols did
not differ significantly (Table 1). Genotype frequency distributions (whole sample, within
patients or within HNV) did not differ significantly across scanning protocols either (χ2=2.65,
p≥0.27). There were no significant differences in sociodemographic characteristics between
HNV with MR5 scans and HNV with MR6 scans. Patients in each imaging protocol were also
comparable on sociodemographics and illness characteristics (Table 1).
MR images were processed using the locally developed BRAINS (Brain Research: Analysis
of Images, Networks, and Systems) software package. Detailed descriptions of image analysis
methods for measuring lobar gray matter (GM) volumes have been provided elsewhere
(Andreasen et al. 1993; Andreasen et al. 1994; Andreasen et al. 1996; Harris et al. 1999). In
brief, the T1-weighted images were spatially normalized and re-sampled so that the anterior-
posterior axis of the brain was realigned parallel to the anterior-posterior commissure line, and
the interhemispheric fissure was aligned on the other two axes. The T2-weighted images were
aligned to the spatially normalized T1-weighted image using an automated image registration
program (Woods et al. 1992). These images were then subjected to a linear transformation into
standardized stereotaxic Talairach atlas space (Talairach and Tournoux 1988) to generate
automated measurements of frontal, temporal, parietal, and occipital lobes, cerebellum, and
subcortical regions (Andreasen et al. 1996). To further classify tissue volumes into GM, white
matter (WM) and cerebrospinal fluid (CSF), we employed a discriminant analysis method of
tissue segmentation based on automated training class selection that utilized data from the T1,
T2 and PD sequences (Harris et al. 1999). In this study, we examined total cerebral GM
volumes, GM volumes sub-divided by Talairach atlas-based cerebral lobes (frontal, temporal,
and parietal), and lateral ventricles.
Neurocognitive Assessment
Approximately 80% (162 HNV and 329 patients) of study participants who provided blood
samples for DNA analysis also underwent neurocognitive assessment. They were administered
a comprehensive cognitive battery by psychometrists who have been trained in standardized
assessment and scoring procedures. Testing generally took approximately 4 hours to complete
and, when necessary, occurred over several sessions.
Full scale IQ, verbal IQ and performance IQ scores were derived from the Wechsler Adult
Intelligence Scale – Revised Edition. Based on a priori theoretical considerations (Green et al.
2004; Hill et al. 2004; Kareken et al. 1995; Milev et al. 2005; Saykin et al. 1994), 33 test
variables from the standardized neuropsychological battery were further grouped into 5
cognitive domains: verbal memory, processing speed/attention, problem solving, language
skills, and visuospatial skills. These groupings of cognitive domains had good internal
consistency (Median Cronbach's alpha=0.80; Range=0.75 to 0.85) (Ho et al. 2003; Milev et
al. 2005). The component neuropsychological test variables used to compute each cognitive
domain score have been previously described (Milev et al. 2005). Prior to deriving cognitive
domain scores, the raw test score from each of the neuropsychological test variable was
converted to a z score (Mean=0, SD=1) based on norms established using a separate database
of 419 healthy volunteers. Scores were reversed where necessary so that a larger negative score
indicates poorer performance below the mean. Using these z scores, each domain score is the
summed average of its component neuropsychological test variables.
Ho et al. Page 4
Schizophr Res. Author manuscript; available in PMC 2009 December 1.
NIH-PA Author Manuscript
NIH-PA Author Manuscript
NIH-PA Author Manuscript
Page 5
Statistical analyses
Genotype and allele frequencies of NEUROG1 SNPs (rs2344484 and rs8192558) in patients
and HNV were compared using Chi-square tests. The strength of association for major allele
on each SNP was further estimated using odds ratio. Because major allele for these two SNPs
have been associated with schizophrenia (Fanous et al. 2007), analyses of genetic effects on
MRI brain morphometry and on neurocognition compared major allele carriers versus
homozygotes of the minor allele. In this paper, only rs2344484 genotype effects on brain
morphometry and on neurocognition will be presented. rs8192558 analyses will not be shown
since both SNPs are in high linkage disequilibrium (D′=0.90; r2=0.46). Furthermore, the
relatively small number of rs8192558 T-homozygotes (N=13 HNV and 17 patients) yielded
low statistical power (β≤0.12) even though rs8192558 genotype effects on brain morphometry
and on neurocognition were similar to those of rs2344484 genotype effects. The former set of
analyses is available upon request.
The effects of NEUROG1 rs2344484 genotype on total cerebral GM, lobar GM and lateral
ventricular volumes were analyzed using ANCOVAs. In each general linear model, the
respective MRI volume was the dependent measure and genotype the independent variable.
Intracranial volume, age, gender, imaging protocol (dummy binary variable) and diagnostic
grouping were entered as covariates. A genotype-by-diagnostic group interaction term was
also included in each general linear model to assess whether genotype effects on brain volumes
differed across patients and HNV.
Analyses of the relationships between NEUROG1 rs2344484 grouping and neurocognition
were also performed using ANCOVAs. The dependent measure in each ANCOVA was WAIS-
R measures of IQ and cognitive domain scores. Genotype grouping was the independent
measure. Age, gender and diagnostic grouping were entered as covariates; together with a
genotype-by-diagnostic group interaction term so as to detect the differential effects alleles
might have on neurocognition across diagnostic groups.
Addition of antipsychotic treatment variables (i.e. lifetime CPZ-equivalent exposure to all
antipsychotics, lifetime CPZ-equivalent atypical antipsychotics exposure or CPZ-equivalent
typical antipsychotics exposure) into statistical models did not change ANCOVA results for
MRI brain volumes or cognition. Since there were no significant main effects of antipsychotic
treatment or genotype-antipsychotic treatment interaction effects on brain volumes or on
neurocognition, antipsychotic treatment variables were excluded as covariates in the general
linear models.
Lastly, two-marker NEUROG1 haplotype association analyses with schizophrenia, MRI brain
volumes and neurocognition were also performed using expectation-maximization algorithms
(results not shown but available upon request). Haplotype associations were generally weaker
but consistent with the SNP genotype findings reported below.
rs2344484 and rs8192558 genotype and allele frequency distributions for the sample are
summarized in Table 2. Genotype frequency distributions on both SNPs differed significantly
between patients and HNV (X2≥11.5, p≤0.003). The major alleles of rs2344484 and rs8192558
(C and G respectively) were significantly more prevalent among schizophrenia patients than
in HNV (Table 2; X2≥9.8, p≤0.0018; Odds ratios≥1.51).
To assess potential spurious association that may arise secondary to ethnic stratification,
comparison of NEUROG1 genotype and allele frequency distributions was repeated using only
subjects of Caucasian ancestry. Restricting to only Caucasian subjects (354 patients and 210
Ho et al.Page 5
Schizophr Res. Author manuscript; available in PMC 2009 December 1.
NIH-PA Author Manuscript
NIH-PA Author Manuscript
NIH-PA Author Manuscript


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Put the Needle on the Record Love vinyl? Need a new record player? Check out our turntable store for a great selection of turntables, needles, accessories, and more.
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Vinyl LP pressing. 2012 sophomore album from the singer, songwriter and international superstar. The album includes production from Mark Ronson, Jeff Bhasker, Emile Haynie, Diplo and Supa Dups, as well as the Smeezingtons, Mars' three-man songwriting and production team. He notes that the album is more musically varied and refuses to "pick a lane". "Locked Out of Heaven" was released as the lead single from the album. It has been described as having strong influences of New Wave, with striking resemblances to "Message in a Bottle" and "Roxanne" by The Police, The Romantics' "Talking in Your Sleep", and even Michael Jackson's "Beat It", while some have mildly referenced it to The Outfield's "Your Love".
C'est vraiment de la bonne musique sur un vinyl de bonne qualité! Ca vaut pleinement ce que ca coute!😊Published 3 months ago by Gabriel
Going to see him in July and I had a horrible dream last night that I missed the concert! NO! His album is great and so is he!Published 17 months ago by Steacy Curry


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Cold Case
Sponsored By
Convicted Killer, 70, Pleads Guilty To 1982 OC MurderA 70-year-old convicted killer has pleaded guilty to murdering a friend in 1982 in Orange County.
Investigators Find Human Skull, Other Remains In Backyard Of Valinda HomeInvestigators on Friday say they discovered a skull and a human skeleton in the backyard of a home in Valinda.
Authorities Continue Dig For Missing Person In San Gabriel Valley BackyardFollowing up on a tip, Los Angeles County Sheriff's detectives and personnel from the Los Angeles County Coroner's office were digging for human remains in the backyard of a residential home in the San Gabriel Valley on Thursday.
Deputies Conduct Investigation Linked To Missing Persons Case From 2009Deputies conducted an investigation on Thursday to linked to the whereabouts of a person that was reported missing in 2009.
Only On 9: Family Suspects Foul Play In 2013 Disappearance Of Missing Antelope Valley Woman"This wasn't a walk-away. This wasn't a voluntary missing," cold case detective Steve Lankford says.
Oxnard Police Hoping Public Can Help Them Solve 2014 Cold Case HomicideInvestigators have yet to determine a motive for the attack that took place in broad daylight.
Only On 2: Third Anniversary Nears Of Fatal Shooting Of Cook Allegedly Killed For Not Preparing Food Fast EnoughOn Thursday evening, CBS2's Peter Daut spoke with Raul Lopez' children who are desperate to have the now-cold case solved.
OC Woman Searching For Mother's Killer Discovers Truth About Her Death And LifeSandra Mitchell talks to the woman whose perseverance over the years has finally yielded answers in her mother's death.
Santa Ana Man, 32, Accused Of 2004 Murder, Sexual Assault Of Reno Preschool TeacherFrancisco Merino-Ojeda of Santa Ana was extradited and booked into jail in Reno on Wednesday in the death of 28-year-old Kyla Annan.
Registered Sex Offender Arrested In 1981 Cold Case Murder Of Pomona BoyA 53-year-old man was in custody Saturday on suspicion of murdering a young boy in 1981.
Report: Los Angeles D.A. Opens Cold Case Murder On Heels Of HBO DocumentaryThe bombshell comes on the heels of new HBO documentary series "The Jinx: The Life and Deaths of Robert Durst."
Cold Case: Arrest Made In 2002 Rape, Murder Of 15-Year-Old GirlA cold case is warming up once again after an arrest was recently made in relation to the 2002 murder of a teenaged girl in East Los Angeles.


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DreamWorks Feature Linux and Animation
I have maya 2011 and would
I have maya 2011 and would love to learn how to use it to the max! any hints or pointers?
information on linux
is 3-d studio max compatible with Linux OS?
3DS Max for Linux
3D Studio Max is not publicaly available for and linux OS because to say linux OS is a very broad comment.
As of now there are over 300 different linux distributions. A distribution is a linux "bundle". These bundles are specially designed to do what ever you want. That is why linux software is distributed in the form of source code. This source code is compiled on your linux distro and therefor is fitted like a glove to your machine.
The reason they don't have 3D Studio Max for ;inux is because they don't want to release their source code, as this it cost money and they don't want to give away their secrets.
But for big compainies like DreamWorks SKG I'm sure that Autodesk would be more than willing to sell them a working linux version (source code).
So the short version is:
3DS Max for linux is for big developers only.
I need 3D Max Software
I need a 3D Max Software bacause is my job
I need 3D Max Software
I need a 3D Max Sogtware bacause is my job
speaking English fucking
speaking English fucking assholes
Not all linux apps have to be free
Proprietary applications are distributed in binary form for linux.
3d studio max is not availible for linux only because YOU (and other users) didnt ever request linux support from the 3D studio's developers.
Or you were simply to few.
3D MAX on LINUX
There are many ways to get 3D Studio Max working on Linux,
WINE is almost like an emulator just like VMWARE. Which will emulate Microsoft. Meaning you can run All of your fancy Microsoft software on LINUX*
Linux and source code
That is not entirely true.
Many softwares come nowadays in binary form for Linux. There are commercial softwares that run on Linux and don't have they're source code open to the public.
Three examples that come to my mind: Adobe's Flash Player, Opera browser and Java Virtual Machines.
That means that if AutoDesk really wants to release 3D Studio for Linux, they can, and they don't risk losing any of their "secrets".
Java Virtual Machines are
Little correction:
Java Virtual Machines are now open source.
True to say that even some Linux Distro's are not free neither 100% open source. RedHat Enterprise edition, SuSE are examples.
Re: GFX: DreamWorks Feature Linux and Animation
hi i always admired with computer animation, and CGI and would like to know the kinda software used, where can i get the resources and who can i refer to..
Re: GFX: DreamWorks Feature Linux and Animation
how do you get hold of basic 3d animation software. how do you get into the business. please tell me
Get Blender!!
You should start out by downloading blender;
This is a free 3D animation and modelling tool...
www.blender.org <--- It may be difficult to use, but all of them are!
Maya is what dreamworks use, Maya unlimited v6.0 is very expensive, you could buy it to learn it, but it's so expensive that the chances of you being put off by it's difficulty outweigh any good stuff.
If you really want to learn Maya, I would advise going to university, I think it was Brighton Uni that does courses in 3D Visualisation if your interested (and in the UK).
Re: GFX: DreamWorks Feature Linux and Animation
I'd like to learn from your tecnics.
I love cartoons but here in my country we don
i want to know more about animation
hi i am a universty student and i want to have my animation film befor i gratuat so show me the tecnicse to do what i want
blender works great
blender works great & there are lots of totorials & books to teach you everything you need to know. there are also video totorials. check out elephants dream. its a open source movie made with blender & a few other open source products. it has all the .blend files on the dvd
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Sitter in 1 portrait
Sylvia, Lady Gleichen(1880-1942), Maid of Honour successively to Queen Victoria and Queen Alexandra
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A human's hair never stops growing, much like a beaver's teeth or a dolphin's thirst for blood. Stay on top of things with this Groupon.
Choose Between Two Options
- $17 for a haircut, style, and conditioning (a $35 value)
- $39 for a haircut, style, deep-conditioning treatment, and partial highlights or single-process color (an $85 value)
Victoria at Xtreme Beauty Hair Salon
At Xtreme Beauty Hair Salon, amid potted plants and hardwood floors, stylist Victoria draws on years of hair styling experience to snip chic cuts and saturate strands with rich color. Patrons can also opt for treatments such as hair and eyelash extensions, teeth whitening, or keratin blowouts.
100% of 17 customers recommend
"Victoria was great! I had a great visit and definitely recommend her services"
"So happy with my hair :)"
"victoria was awesome!!! fr the moment i walked in the front door she was very approachable and vivacious!! it was a nice warm welcome fr a lady ive never met! so i..."
"victoria was awesome!!! fr the moment i walked in the front door she was very approachable and vivacious!! it was a nice warm welcome fr a lady ive never met! so i knew my hair was in great hands. ive never colored, so she was very meticulous in taking the time to give me something i loved. i appreciated it more when she wasnt rushing her services or half a**ing it bc it was so time consuming (we had to lighten the color cus the first time it didnt look the way i wanted!). even after, she styled it to perfection. what amazed me more was when i said layers, she knew exactly how to cut it. ive never found one who finally got it right til victoria!! ive found me my go-to!!"
24757 Washington Ave.
Murrieta, CA 92562
+19512009872Get Directions


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Get cagey with the Savoy House Connell collection, designed by Brian Thomas! Great industrial style comes courtesy of the cages protecting each shade of clear seeded glass and the sleek arms are finished in bold English bronze.
Climb into your horse drawn carriage and go back in time with the Liberty collection. A dignified Colonial design with a rustic Walnut Patina finish almost makes this collection an American treasure.
A grand welcome for any stately address - at an incredible price. finished in Slate with pale cream seedy glass, these fixtures create an easy appearance of unmistakable exterior elegance.
The St. Laurence family is fashioned of New Tortoise Shell and Silver finish with Antique Cream drip candle covers and Crystal drops.


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Alliance for Contraception in Cats and Dogs
This organization is dedicated solely to furthering the development of non-surgical methods of pet population control.
Humane Alliance's Big Fix Rig
The Big Fix Rig's presence in the Gulf Coast region will allow groups in both states to offer low-to-no-cost spay/neuter surgeries to residents and feral cat caregivers through the Humane Alliance's high-volume spay and neuter system.
September 1, 2015
Reunited … and It Feels So Good
Is your organization creating barriers to successful lost pet reunions? Read how one shelter adopted a new approach to boost reclaim rates.
September 1, 2015
Saving the Strays of Puerto Rico
Low spay/neuter rates, euthanasia rates around 90%, and cruelty laws that are mostly unenforced are the norm in Puerto Rico. See how The HSUS is working with the Puerto Rican government to create a brighter future for its street dogs and stray cats.
July 1, 2015
Cats and Community Coffers
Commnity cats are thriving in Port Orange, Florida, thanks to a city-supported trap-neuter-return program.
July 1, 2015
Southern Success
Southern Pines Animal Shelter in Mississippi has modest resources and a huge service area. (sound familiar?) But by reaching out to its community with a diverse range of programs and improvements, the shelter has created a culture of adoption that's sent intakes plummeting and live releases soaring.
May 1, 2015
Taking the Show on the Road
Mobile spay/neuter clinics have their advantages and downsides. So before you hit the road, make sure you understand both the burdens and benefits of running a mobile clinic.
January 1, 2015
Sharing Spaces
A collaboration between cat and bird advocates in Oregon demos spaces that keep both species safe.
September 1, 2014
NiPPed in the Bud
Washington Humane Society develops Cat Neighborhood Partnership Program aiming to improve the lives of community cats in Washington DC.
September 1, 2014
The Road to Happy Returns
To safely trap and transport feral cats for their spay/neuter surgeries, you need more than good intentions. While the business of setting traps and transporting cats from colony to clinic and back isn't brain surgery, there's more to it than some novices think.


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Midwest Auto StoreRead MoreAre you ready to test and browse some cars? Midwest Auto Store sure is! With so many cars to see, at the perfect price points, you'll love going car shopping in Florence. Midwest Auto Store will help with any necessary tire changes and rotations you need. Time for an oil change? This bar has you covered. So check out all the great models at Midwest Auto Store today and roll out with a great new ride. As far as body shops go, Midwest Auto Store is simply the best! Come see what they're all about today. With so many great auto services, your car will be looking good as new after a trip to Midwest Auto Store.166 Weaver RdFlorence, KY US
Bruce's GroceryRead MoreDon't hire your construction or handy work out. Save some money by learning how to complete these projects yourself with the best hardware found at Bruce's Grocery in Florence. Produce like this is not just nutritious...it's delicious, too! For cool, refreshing H20, Bruce's Grocery's got you covered. Bring out your Italian side in the kitchen and create a yummy pasta dish with some noodles from Bruce's Grocery. When you're trying to upgrade your cooking, adding flavor is essential. Create supple and tarter flavors by exploring the wonders vinegar and oil can add to your cuisine by shopping for them here. Make sure you always have the ingredients to make a delicious dessert on hand. Purchase some new spices and seasonings from here and treat yourself to a fun and creative night cooking in the kitchen. Need a sandwich for lunch or toast to compliment your hearty breakfast? Grab a loaf of bread today. Feeling hungry? Your favorite healthy and light snacks are waiting for you at Bruce's Grocery. If you're looking for beverages that will handle all your hydration needs, look no further. This drink will refresh, renew, and refuel your energy. We all could use a little dairy in our diet, so why not add some to your day and pick it up at Bruce's Grocery? You'll feel great knowing you're getting just the right nutrition. Start your long and busy work week off on the right foot with a tasty and energizing coffee or tea from Bruce's Grocery. You won't be able to tell the difference with the frozen foods available here for your cuisine convenience. Cereal might be the best part of waking up. Pick up your favorite box today. You'll be amazed at how delicious the canned food is when you purchase it from Bruce's Grocery. Meat lovers rejoice! From chicken to beef to pork, the meat selection here is sure to please. Feeling hungry? Heat up a tasty and affordable TV dinner from here and enjoy the convenience of a quick meal. Not only is fish great for your heart, but it also packs a punch in the flavor department, so get to grilling! Luckily, Bruce's Grocery is only a short walk away from available parking. Find all your favorite household tools in one place. Bruce's Grocery will help you get the job done.8430 Dixie HwyFlorence, KY US
Halloween ExpressRead MoreFeeling bold and creative? Dress up your next meal with some unique and tasty seasonings and spices from here. Hungry for a tasty meal but don't have the time to spend in the kitchen? Frozen food is an easy solution. Loaded with essential vitamins and minerals, the produce from this store will give you the energy your body needs. If you're just getting into cooking, pick up some oil and vinegar from here and learn the basics of cooking with these necessities. With a bottle of water in hand, it's easy to refresh and refuel. Grab a couple drinks from Halloween Express and stay on the go all the time. Bread is a kitchen must-have, so pick up some fresh goodness today. Fashionistas rejoice! At this store, you will find great women's clothing items at a price you can't find anywhere else. Switch up your weekly pasta routine with a new and exciting pasta recipe. Grab some noodles from Halloween Express and get cooking. If milk is your go-to beverage, you'll love the dairy products available here (great for strengthening your bones and teeth). Experience a new blend of coffee or tea from Halloween Express and sip your way to happiness. Find quality, tasty, and affordable meats here and leave with enough meat for the whole week. Make sure you always have a variety of beverages on hand, especially during the warmer months. This drink is sure to take care of business. A simple solution to long hours spent over the stove, a microwavable meal will trick your taste buds into thinking it was made from scratch! Ready, set, fish! For heart-healthy fare, super fresh seafood is readily available. The healthy and tasty canned food items from Halloween Express make great side dishes and cooking ingredients. This fixing adds that little something extra to any baked good, so include it in all of your favorite recipes. Cereal in the morning, cereal in the evening, or cereal at suppertime. With the selection here, you'll want to eat cereal anytime. Planning a movie night? Stock up on all of your favorite snacks and munch and crunch all night long. Parking is plentiful, so visitors can feel free to bring their vehicles.7505 Sussex DrFlorence, KY US
Value City FurnitureRead MoreIf you're ready to get rid of your old furniture and upgrade to a more modern look, check out the selection of pieces at Value City Furniture in Florence. For the latest and greatest in bedroom furniture trends, browse the selection of options here, such as bedroom furniture. Making over your bathroom is super simple with the cute and affordable furniture selection. Deck out your deck with the perfect patio furniture, you're sure to find a summer style you love. Small changes in comfort can yield large results in productivity. By finding ergonomic chairs at store, you could be giving your employees more comfort while maximizing profits. This store has a huge furniture selection, including living room furniture. Mattresses and mattress pads and covers are just some of the many affordable and comfortable bedding options that this store has to offer. If you have a desire to decorate your walls, start off on the right foot with items like curtains and mirrors. Even if your aesthetic tastes are as different as can be, you and your loved ones will fulfill all your home decorating needs with items like rugs, throw pillows, and vases. Pushing the boundaries of conventional artwork, this Value City Furniture features one-of-a-kind pieces that will easily dress up any room. If you are concerned about parking, you shouldn't be. There are plenty of parking options in the area. Looking for a great new statement piece for that one room in your house? Browse the exquisite furniture collection at Value City Furniture in Florence.8032 Burlington PikeFlorence, KY US
Furniture FairRead MoreIf you're ready to get rid of your old furniture and upgrade to a more modern look, check out the selection of pieces at Furniture Fair in Florence. Living room furniture are just some of the high-quality and comfortable furniture items available. New bathroom furniture can be a great household update. Come see the selection at Furniture Fair. When your bedroom needs a revamp, find dressers, bed frames, and bedroom furniture and more great furniture pieces here. Give your home or work office the makeover it deserves with some brand new furniture from this store. Find cute furnishings for your backyard or patio and have the whole family over to your place for an outdoor get-together. When it's time to update your bedroom, you can shop a wide selection of options here such as mattresses and mattress pads and covers. Sharpen your artistic eye with a little help from this store — even the most impressive artists are dazzled by the stunning pieces on display. Items like rugs, throw pillows, and vases will provide your home with that much-needed flair, so get to decorating. Nobody likes looking at a blank slate, so consider hanging a little something on your wall. Pieces like curtains and mirrors are just a few suggestions from here you're sure to love. If you plan on driving, you'll appreciate the great parking options nearby Furniture Fair. Stop by Furniture Fair in Florence today for a new furniture set and go home with something you will love to lounge on.5015 Houston RdFlorence, KY US
Thomasville Home FurnishingsRead MoreIs it time you gave your home a makeover? Find a generous selection of top-notch furniture at Thomasville Home Furnishings in Florence. If you're looking to revamp your wardrobe, head to this store and browse the latest selection of women's attire. Next time you're in need for a living room update, the choices at this place are endless for that very purpose. With such options like living room furniture, you'll definitely be happy you came. Find cute furnishings for your backyard or patio and have the whole family over to your place for an outdoor get-together. Brand new furniture is a great way to clean up a workspace that's just a tad too messy. Make sure everything in your bathroom matches and browse the furniture selection for all the best designs. Your new and trendy bedroom furniture set is waiting for you. Come browse a variety of options, such as dressers, bed frames, and bedroom furniture, and go home with a new bedroom set. It's time to make your living space even more livable with rugs, throw pillows, and vases. Wall decorations such as curtains and mirrors are sure to catch your eye, so stop in and see what else is on hand. If you're in need of some design tips, head on over to this store and peruse the exquisite pieces on display. Endless parking options are readily available close to Thomasville Home Furnishings. Broken bookcase? Uneven table? It may be time to get some new stuff, so make your way to Thomasville Home Furnishings today.39 Spiral DrFlorence, KY US


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Play Video
Erika Jayne in Fort Lauderdale
Posted by ErikaJayne on Apr. 08, 2010
Tom Lennon is here to tell you that many things belong in a bun, but your h...
Tom Lennon tells you how to man up and break up.
Jump on your magic carpet and revisit the classic Disney animated film abou...
Posted by ErikaJayne on Apr. 08, 2010


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Baby Bear's Sled
By TaleSpring LLC
Open iTunes to buy and download apps.
When Baby Bear gets a new sled he's off to the hills for a sledding adventure. Young readers will enjoy taking to the hills with Baby Bear as he runs into just about everything in his path and experiences some funny encounters with trees, bears, squirrels and more.
Author:Pam Miller
Illustrator:Pam Miller
Created at TaleSpring.com! Come create your own interactive ebook!
View In iTunes
This app is designed for both iPhone and iPad
- Category: Books
- Released: 17 March 2012
- Version: 1.0
- Size: 5.4 MB
- Language: English
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Orson Welles made the greatest movie of all time and some disastrous commercials.... READ ON
The legendary actress and humanitarian, who would have been 86 years old today, was much more than just a pretty face.... READ ON
Set it! Forget it! And say happy birthday to the godfather of infomercials.... READ ON
Here are 10 things you might not know about the legendary outlaw country singer.... READ ON
Rod Serling's groundbreaking anthology series introduced some enduring science-fiction themes and one of the most iconic title sequences in TV history—not to mention a slew of famous guest stars.... READ ON
Michael Corleone as Han Solo? A look back at the many iconic roles that could've been for Al Pacino, who turns 75 years old today.... READ ON
It's always a bit unnerving when you're certain you know what a song is about—then find out later you were way off base.... READ ON
In 1943, Charlie Chaplin became embroiled in a famously scandalous paternity suit that would change the future of family law in America.... READ ON
Things can get nasty.... READ ON
The little plastic bit on the end of your shoelace is called an aglet.


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Rusev and Lane engaged
Most wrestling fans know that Rusev and Lana are involved in a real life relationship and have been for some time now. It appears that the two of them might be taking things up a notch. Speculation has arisen that they are now engaged to be married soon. The cause of the speculation is that the blonde bombshell can be seen wearing what looks like an engagement ring in a couple of social media photos.
October 3, 2015
Ziggler dating Lana
Deep down, the root of professional wrestling is pulling the wool over the eyes of fans and making them believe that something is real when it is not. Dolph Ziggler and Lana obviously embrace that rule, as the two of them have taken to social media to make their relationship seem as real as possible. That has led to quite a few WWE fans being confused. In reality, she is still dating Rusev.
August 31, 2015
Fans bash Lana
Over the weekend, Lana had herself an unpleasant encounter with wrestling fans when she posted a photo of herself on social media without wearing any makeup. The Ravishing Russian was trashed by unruly fans who told her that she was ugly. She posted a video response stating that she still loves herself despite her imperfections.
July 20, 2015
JBL apologizes
Since he unintentionally upset the internet wrestling community, JBL decided to go on social media to provide an apology and an explanation. He stated the "zombie Eddie Guerrero" comment was done in jest and that he would never insult his good friend. The WWE commentator also stated that he had just discussed the Rick Grimes character from the Walking Dead television series. That was why he made the reference to Guerrero being a zombie.
February 4, 2015
WWE reviving European belt
For years now, a good amount of fans have been yearning for WWE to bring back the European title. Well, thanks to a social media post by Lana, those flames have been spread even further. She posted a photo of what looks to be a new version of the belt, complete with multiple flags and the new company logo. Many had been speculating that Rusev would be the one to convert the United States Heavyweight Championship into one that suits his character.
December 14, 2014