text:
After ISIS Killed His Friends, This Guy Founded a Security Firm to Kill ISIS
"Anyone who kills friends of mine has made himself my target. I won't stop until ISIS is destroyed."
"Anyone who kills friends of mine has made himself my target. I won't stop until ISIS is destroyed."
Ben Rubenstein got a $100,000 grant to help him study how machine learning can go wrong.
Last week, as millions of Americans got hyped about the Fourth of July, two men brutally tortured by the US government were quietly released from prison.
The proliferation of threats across the Middle East has forced the US to focus its defense strategy on bolstering the military capabilities of its strongest ally in a region perpetually gutted by turmoil.
The CIA released declassified versions of five internal documents "related to the Agency's performance in the lead-up to the attacks."
We asked people shut out of clubs in Newtown what they thought the problem was.
The big takeaway from the 25th Annual ASIS NYC Security Conference and Expo was that catastrophe could strike at any moment, and the only way to stop it was through beefed-up and intrusive security initiatives.
The 2011 earthquake in Christchurch affected everyone in the city's limits, but one group who are still peculiarly disadvantaged are sex workers.
An investigation by the Associated Press uncovered five instances where intruders actually made it onto airplanes.
All the targeted churches were Catholic and have previous links to sexual abuse.
This month an Invercargill public pool has been battling to uncover the identity of a mystery pooper.
A new report suggests the US intelligence apparatus is improving amid growing civil liberties concerns in post 9/11 America.
The Government is about to publish their long-term defence strategy and Alan Dupont is worried. We asked the security expert and former diplomat about why Australia is falling behind the times.
The country's booming population of billionaires means that bodyguards are in high demand—particularly women, who are valued for their covert presence, precision, and elegance.
Iggy Azalea became the butt of many jokes this week when she ranted on Twitter about a Papa John's pizza delivery guy giving out her phone number, but her pizza feud exposes serious privacy issues.
Community groups were promised $13 million from the government to develop de-radicalisation programs. They're still yet to see that money.
President Obama is pushing a series of new cybersecurity initiatives that could weaken, and even criminalize, independent research into data vulnerabilities.
We should salute cops when they do their jobs, but law enforcement heroism can't be used to delay police reform.
The International Security Conference and Exposition is a rare window into the world of physical surveillance that usually remains hidden in secret command and control centers.
As stampeding crowds rush the nation's retailers little is being done to keep the peace.
"What's happening in Ukraine now matters to criminals from Bogotá to Beijing."
The Secret Service has a number of phantoms to confront, including a cadre of supervisors who might have been good agents but make very bad managers of human beings. Another big problem: rampant alcoholism.
In the shadow of our most recent military venture into Iraq, Australia is currently debating a raft of new anti-terror laws.
The grim specter of the Islamic State loomed heavily over the NATO summit. The jihadist group dictated the agenda of the event being held at the five-star resort in Newport and nearby Cardiff Castle.


text:
There are many classic comedy routines, but none is more lauded than the one in which someone walks toward a banana peel and places it in the garbage. Enjoy throwaway gags with this GrouponLive deal.
The Deal
- $29 for a comedy show package for two (up to a $133 total value)
- When: select Wednesdays–Sundays, through August 4
- Where: Pittsburgh Improv
- Door time: 60 minutes before the show
- Ticket values include all fees.
- Click here to view the show calendar.

Package Details
- Two tickets to a comedy show (up to a $40 value)
- Two Yuengling draft beers or two non-alcoholic beverages on first visit (up to a $6.50 value each)
- Four vouchers for tickets to future shows, which may be shared with friends (up to an $80 value)

Upcoming Performances
Jeremy Hotz (May 10–12)
Comedian with a worldview best summed up by the title of his 20120 standup special, What a Miserable Show This Is…
Warning: contains profanity and unsafe hot dogs for those with dairy allergies
**John Henton (May 23–26)**
Known best from his roles on The Hughleys and Living Single, John Henton has graced late-night shows such as Showtime at the Apollo, The Tonight Show Starring Johhny Carson, and Comics Unleashed.
**Tommy Davidson (June 27–30)**
Climbing to fame as a cast member of the innovative sketch show In Living Color, Tommy Davidson's versatile physicality and spot-on impressions have won him national acclaim. The mid-'90s saw Davidson transition from the small screen to the big screen as he starred in such blockbusters as Woo, Booty Call, and Ace Ventura: When Nature Calls. His high-energy performances even earned him three standup specials on Showtime. Warning: coarse language
93% of 716 customers recommend
"Just be prompt to get a parking space"
"the Improv is a great place , had a really nice nite out, easy access to parking, good seating at the venue, staff very efficient and attentive, food smelled and..."
"the Improv is a great place , had a really nice nite out, easy access to parking, good seating at the venue, staff very efficient and attentive, food smelled and looked great as it passed by, next time we plan on eating there. drinks are a bit expensive so be prepared, Groupon special is well worth it... it was nice to take friends out with us for an entertaining evening and the best part about the Groupon is that we get to do it again, for free!"
"Great groupon! "
166 East Bridge Street
Homestead, PA 15120
+14124625233Get Directions

subset: commoncrawl


text:
Listed since: 12.05.2009, 13:07
See also: Creative ZEN Mozaic EZ100 8GB pink
1 of 1 visitors recommend this product (100%).
Rating: (94%) (Rate product)
Creative ZEN Mozaic EZ100 8GB black (70PF244409115) saved
Using the "offers from" options you can filter merchants from regions which are most common in our database: the UK, Germany, Austria and Poland.
If a checkbox near a flag is selected, offers from merchants from that particular region will be displayed, otherwise they will not be visible.
If you select offers from "all regions", all offers from all merchants will be displayed. These incude offers from merchants in countries not listed here.


text:
Content tagged with "Mining Waste"
Troubled Waters – and no bridge to cross them
Payal Sampat | February 28, 2012
Mining reform versus jobs: A false choice
Lauren Pagel | September 16, 2011
No issues articles contain that tag.
Troubled Waters
EARTHWORKS and MiningWatch Canada | February 28, 2012
Kensington "Fill" Permit
U.S. Army Corps of Engineers, Alaska District | July 5, 2005
Press Release - Unlimited Toxic Waste Dumps Allowed on Public Lands
| October 10, 2003
Montana takes action on mine waste after B.C. dam failure
Vancouver Sun | Gordon Hoekstra | Sunday, June 07, 2015
Obama administration must act to avoid mine waste disasters
Earthworks, et al | Thursday, March 19, 2015
Waters of the World Threatened By Dumping of 180M Tonnes of Toxic Mine Waste
Earthworks, MiningWatch Canada | Tuesday, February 28, 2012


text:
Specializing in rodeo performance horses such as barrel racing, roping, steer wrestling, team roping and breakaway.
FOR SALE: 3412 s/f home, 4 bedrooms, 3.5 baths, office, bonus room, Upgraded to max. Great for entertaining as well as for your horses. 4 sand paddocks…
Natural horsemanship, hunter/jumpers, horse sales, lessons
Breeding quality Foundation Quarter Horses. Also standing Andalusian stallions and a Friesian.
posting ads and taking and making photos and flyer's for horses for stud and for sale. And helping owners find for ever home for there horses.
Family Oriented Welsh Ponies and Cobs. Boarding and Training also available.
Hunter/Jumper Lessons and Training in Chino, CA
Full service training facility located in Riverside. Specializing in children & beginner riders. Training & instruction offered in Hunters, Dressage…


text:
The third Trader Joe's grocery store in the state is headed to Brookfield, having been approved last year as part of the Target development on Bluemound Road.
On Monday, the Brookfield Plan Commission approved the visuals of this sight plan for the project along with the aesthetics of the grocery store's façade.
Alderman Gary Makhorn said that in his time as an elected official, getting a Trader Joe's to Brookfield is one of the top 10 most asked about topics, up there with property taxes on the list.
The 12,500 square-foot grocery store will use most of the same materials as the Target in the Underwood Crossing development, including the same stone and a similar brick. Located in the northeast corner of the plot next to a retailer to be named later, the national upscale grocer will have a single entrance on the Bluemound Road side.
There will be 140 spots in the parking lot on the parcel, which will be separated, to some degree, by landscaping from the store to the west. City officials did admit that they were relaxing the long-standing policy of buildings being aesthetically accounted for on all four sides since a grove of trees will essentially hide the south side of the building.
Accommodations were made to strategically place dumpsters to minimize their visibility from drivers crossing Bluemound. A 250-foot buffer assuaged the fears of city officials. Also, a wall specifically designed to keep the grocery carts out of sight was part of the plan.
A recommendation from the Plan Commission still must be approved by the Common Council, which could be as soon as next week's meeting.
This site uses Facebook comments to make it easier for you to contribute. If you see a comment you would like to flag for spam or abuse, click the "x" in the upper right of it. By posting, you agree to our Terms of Use.
E-mail Newsletter
Your link to the biggest stories in the suburbs delivered Thursday mornings.
Enter your e-mail address above and click "Sign Up Now!" to begin receiving your e-mail newsletter Get the Newsletter!
More from News and Features
- Bus shelter advertising approved by Brookfield aldermen
- Ask Now: Wisconsin Ave. extension still in the works?
- Brookfield and Elm Grove Mystery Photo Contest: Oct. 1
- The Corners, in the town of Brookfield, adds a women's fashion store to its growing list of tenants
- Brookfield city council to meet Tuesday at 7:45 p.m.
- Brookfield church hopes to bring residents, local music together
- Auditions at Brookfield's Wilson Center may take singers to the Met
- Elm Grove proposed budget requires reduction
- Brookfield East High School recruits students for new DECA chapter
- Brookfield drunk driver leads police on 80 mph chase


text:
Women's Varsity and Novice Eights Take Silvers At Frostbite Regatta
Nov. 15, 2004
Philadelphia, Pa. - Loyola's women's varsity eight and novice eight boats both grabbed silver medals despite viscious conditions on Saturday afternoon at the Frostbite Regatta held on the Schuylkill River.
The Greyhound women's varsity eight finished in second place, just five seconds behind the winner, Temple. Loyola, which clocked a time of 5:03.60, defeated third place Georgetown by six seconds as it experimented with sprint stroke speeds according to Head Coach Al Ramirez.
"We pushed hard to raise the stroke rate to sprint speeds with mixed results," said Ramirez. "Although some felt it was too high too soon, the boat still managed a great finish."
The women's novice eight, which rowed a time of 5:25.94, fell only to Saint Joseph's (5:18.65), while it beat Lehigh, Temple and Penn State.
Loyola's men's varisty four and novice eight boats each earned third place finishes. The varsity four race was extremely tight with Loyola (4:56.98) falling to the winner, LaSalle, by .88 seconds, and second-place finisher, Ithaca, by .86 seconds.
The Greyhound novice eight (5:04.93) finished third, 19 seconds behind first and second place finishers, Colgate and Lehigh, respectively.
Loyola took fourth in the women's novice four race with a time of 6:37.23, fourth in the men's novice four race with a time of 6:03.36, fourth in the women's novice eight race with a time of 5:52.51, fourth in the men's novice eight race with a time of 5:27.55, fifth in the women's four race with a time of 5:28.68, and fifth in the men's varsity eight race with a time of 4:33.87.
More Headlines
Eight Greyhound Teams Recognized By NCAA For...
Eight Loyola University Maryland athletic teams were recognized Wednesday by the NCAA for being...
Women's Eight Competes In Patriot League...
he Loyola University Maryland women's rowing team completed competition at the 2015 Patriot...
Men's Pair Continues To Find Success At Dad...
After finishing first in the qualifying heat Friday morning, the Loyola University Maryland men's...
Men's Pair Advances After Day One At Dad Vail...
The Loyola University Maryland rowing team, along with thousands of crews from more than 100...
Strong Showing For Crews At Kerr Cup
Two second-place finishes guided the Loyola University Maryland rowing team to a strong showing...
Rowing Competes In Final Day Of Knecht Cup
The Loyola University Maryland rowing teams put together a strong finish on the final day of the ...
Men's Pair Advances To Grand Final At Day...
The Loyola University Maryland rowing team had a strong showing at the first day of the Knecht...
Crews Compete For Second-Straight Day At...
In the second-straight day of competition, the Loyola University Maryland men's and women's crew ...
Saturday, Oct 10 EVENT LOCATION TIME COVERAGE Navy Day Regatta Philadelphia, Pa. All Day Saturday, Oct 17 EVENT LOCATION TIME COVERAGE Head of the Charles Regatta Boston, Mass. All Day Sunday, Oct 18 EVENT LOCATION TIME COVERAGE Head of the Charles Regatta Boston, Mass. All Day Saturday, Oct 24 EVENT LOCATION TIME COVERAGE Head of the Schuylkill Regatta Philadelphia, Pa. All Day Saturday, Oct 31 EVENT LOCATION TIME COVERAGE Head of the Occoquan Regatta Fairfax, Va. All Day
Team Information• Roster
History & Records
Coaching Staff
Social Media
Row For Humanity


text:
This item is currently out of stock.
UNIF Hardcore Bomber Jacket is for our hardcore babes with a touch of pastel princess in them. Perfect for those days if you can't decide if yer a CoCo or Darby. Why not More...both! Check out the sweet raised stitching all over. This ain't some cheaply printed on shit, it's been embroidered with rad magical deetz like unicorns and rainbows. Reads "Make Believe" on the front and "Hardcore" on the back. Looks tough on the front, but it's all party on the back. This adorable jacket is slightly puffy so it's cozy enough to keep ya warm but lightweight enough to rock all day cuz yer never gonna wanna take this off.
Join the Misfits
Dope, Yer part of the DK fam! check dat email BB.
Dolls Kill is an active subversion of the fashion industry's "norm". We want our kult members to experiment with their individual style and encourage them to let their freak flags fly. Read More...
International Callers: +1-415-932-7625


text:
Top Definition
the situation in which a person or persons in motor vehicles slow down in the presence of police with the intent to look at what the police are currently doing. This situation can be generalized to any situation in which a person intentally slows down to look at something which is none of their business.
Look at these brothas po'gawkin right here.
by Hood Rich August 08, 2006


text:
Scientists are confident that the new cervical cancer treatments being developed will help to bring the global problem under control.
The second most common form of the disease in women across the world, cervical cancer affects around 3,000 British women every year.
However, Professor Mark Schiffman, a researcher at the US National Cancer Institute, is confident that the "enlarging repertoire" of prevention options has potential to reduce the number of cases.
Writing in the medical journal the Lancet, Professor Schiffman and his colleagues refer to vaccines against human papillomavirus (HPV), a major cause of cervical cancer.
For example, one such vaccine - Gardasil - is currently being considered by the Department of Health for a vaccination programme of 12 and 13-year-old girls.
The researchers wrote: "Because of the importance of the [cervical cancer] problem and the feasibility of ameliorating it, we hope to see a major decrease in the numbers of women affected with this cancer within our lifetimes."
Ed Yong, health information officer at the charity Cancer Research UK, commented: "Vaccines against HPV are an exciting development and they could help to prevent about 70 per cent of cervical cancers in the future.
"But there are many questions about the vaccines that still need to be answered, including how long the immunity they provide lasts for. For the moment, going for cervical screening is the best way of preventing cervical cancer and even with the vaccines around, it will still have an important role to play."
Independent advice on private healthcare


text:
Slideshow: The Best Drinks We Drank in January
Mustachi-ode at Booker & Dax, NYC
"I can't stop thinking about the "Mustachi-ode" from Booker & Dax, the mad science cocktail laboratory in NYC's East Village: bourbon, Nardini amaro, a little bit of lemon, and the Czech liqueur Becherovka shaken with egg white and pistachio syrup (this being Booker and Dax, the pistachio syrup is centrifuged). The bourbon, pistachio, and egg white make for a smooth canvas on which the various herbal and warm spice notes of the Becherovka and Nardini really emerge. And the Angostura mustache on top? Priceless."—Carey Jones, Senior Managing Editor
Cask-conditioned Jolly Pumpkin Noel de Calabaza at Abbot's Cellar, San Francisco
"Maybe my favorite beer from Jolly Pumpkin, I was super excited to tap a rare cask of this barrel-aged treat. Monstrously complex and sour with a slick, velvety mouthfeel from its cask presentation. Amazing stuff!"—Mike Reis, beer contributor (and co-director of beer at Abbot's Cellar & Monk's Kettle)
Sugarcane and Kumquat Juice
"While traveling through Vietnam, we stopped at a little side-of-the-road place outside of Saigon that was pressing fresh sugarcane juice. It was spiked with some tart kumquat juice (also fresh-squeezed right there in front of you) so it's not overly sweet at all, just incredibly refreshing."—Erin Zimmer, National Managing Editor
Grandma's Sweater at Trick Dog, San Francisco
"I have to admit, with all the hype leading up to the opening of Trick Dog in the Mission this month, I was wary. It seemed a little too-cool-for-school, and I'm not the coolest. But this bar has completely won me over. The bartenders are friendly and fun, the room is filled with neighbors, and the snacks are tasty (try the brussels sprouts.) My favorite drink on the menu—and I've tasted most of them now—is Grandma's Sweater, a gin concoction made with fresh lime, blood orange, and Zucca amaro, plus mint and bitter lemon soda. The St. Elmo's Fire, made with white rum, Averna, pineapple, lime, and coconut vinegar, served over crushed ice, is another favorite. But don't feel like you have to study the menu: the bartenders, especially Chad Arnholt and Morgan Schick, will mix up whatever you're craving, just name a spirit and a style and they'll run with it. "Bitter and sour" recently led to a delicious Campari-lime-cassis mixture served up, while "mezcal, with some fruit in it," ended up being an awesome delicately smoky mezcal sour with Chartreuse. Go early, though—the bar seats tend to be taken by 5 p.m., and the music goes from mellow to party after 7 or so."—Maggie Hoffman, Drinks Editor
The Bank Robber at The Marrow, NYC
"I'm a strong drink, dark spirits kind of guy, but also a lover of bitter cocktails like Negronis. That makes The Bank Robber at The Marrow exactly my kind of drink. It's really a Boulevardier; that is, a Negroni made with bourbon. In this case, the bourbon is Bulleit, the vermouth is Punt e Mes, and the Campari is Campari. It's bracingly bitter, ice cold, and dangerously tasty."—J. Kenji Lopez-Alt, SE Chief Creative Officer
Sparkling Ribolla Gialla from Vare Vineyards, California
"George Vare ported Ribolla Gialla vines back in a suitcase from Josko Gravner's estate in Friuli, Italy. If Ribolla Gialla is starting to take off in Napa, it's thanks to George. He makes a minuscule quantity of sparkling 100% Ribolla Gialla each year that he bottles by hand and labels for a lucky few. This was an absolute honor to drink, singularly delicious and fascinating."—Stevie Stacionis, Weird Wine Grapes columnist
Almanac Barrel Noir
"Almanac Beer's brand-new Barrel Noir snuck in at the very end of January to snatch my most-memorable-drink-of-the-month title. The heady, intense brew tastes like a blend of a rich imperial stout, and a sweet, deep Belgian dark ale. Aged in a charred oak bourbon barrel, the beer has an intense, vanilla-sweet smell, which mellows to notes of nutty brown sugar with the first sip. Barrel Noir thankfully avoids the syrupy-sweet nature of some strong barrel aged brews; instead, the finish is clean with a kick of hoppy bitterness, making it all the more drinkable. I can't wait to share a bottle of this as a digestif, perhaps paired with some funky cheese and dark chocolate. Or, maybe I won't share after all."—Lauren Sloss, San Francisco contributor
High Mountain Jin Xuan oolong from Everlasting Tea
"Leandra's boyfriend Sammy has started a tea company that specializes in Taiwanese tea called Everlasting Tea. I got to taste some of his teas last week, and though I've dug them all, this High Mountain Jin Xuan oolong is my favorite. It's full of the floral-misty nuances that characterize high mountain oolongs, but there's also sweet and creamy depth beneath the slightly vegetal taste of the brew. It's my current 'good morning' tea."—Max Falkowitz, SENY Editor
Next of Kin at Aska, Brooklyn
"In the Next of Kin at Aska in Williamsburg, tart kombucha is made from pu-erh tea and mixed with aquavit and caraway syrup. All that delicious caraway had me daydreaming about pairing the cocktail with an everything bagel and lox."—Jaclyn Einis, NY cocktail contributor
Ginger Milk Tea from Teado
"Teado is my go-to spot for milk tea near Serious Eats HQ. And when my bones are freezing and my throat feels like sandpaper, I go for a hot ginger milk tea. It's got a clean, sharp ginger flavor, tempered by a heap of sweetness (you can ask for less sugar, but I've never done that because...why) and Lactaid. Just what a cold day needs." —Robyn Lee, AHT editor and photographer/illustrator
Maple Old Fashioned at Nita Lake Lodge in Whistler, British Columbia
"In true Canadian fashion, the old fashioned at the Nita Lake Lodge in Whistler, BC uses maple syrup as a sweetener. Sipping it from the cozy hotel bar, looking out at the iced-over lake and snowdrifts, it's easy to see why Americans think Canadians all live in a frozen wonderland and put maple syrup in everything. And easy to be convinced that this is the way to live."—Naomi Bishop, Seattle cocktail contributor
"My main pregnancy craving for the month of January has actually been milkshakes. We went to dinner the other night and my "second dinner" was a waffle and chocolate milkshake. My dad made me an awesome milkshake with Ben & Jerry's Half Baked and UBet's Chocolate Syrup. Me drinking milkshakes = very happy baby!"—Jen Weinberg, Ad Sales Director


text:
Description: ANETTE -
Image was hearted from anettee95.blogg.no
Other images from this site
. was first to heart it
35 people have hearted this image
You might like these too
Now available in your language!Use in your language! Go back to English
Other images from this site
You might like these too
Sign in with Facebook or Twitter to start your gallery.
Sign in with Facebook Sign in with TwitterDon't have Twitter or Facebook? Skip this step!


text:
View Leon Liebman's Comments BY TICKER:
Latest | Highest rated
The First Metric Regional Bank Investors Should Know [View article]
I suggest that one other factor may account for its rich valuation. GBCI is the most likely and appropriate acquirer of small banks in its geographic markets. It has done this for many years. It has a track record of holding on to selling management. It has a strong balance sheet and within it a strong cash position. This has enabled it to buy using a blend of cash and shares in their offers.
So, as far as I can remember, GBCI's offers are always accretive.
When we buy GBCI shares we will get a combination of organic growth plus earnings accretion from the small bank purchases. Perhaps that latter factor should be considered in owning GBCI.Sep 18, 2013. 08:53 AM | 0 Likes |Link to Comment
Glacier Bancorp: Acquisitions And Rising Dividend Make This Regional One To Watch [View article]
The increase in GBCI's share price (and PE) in the last year effectively reduces the number of shares required to acquire a desirable bank. I suspect that GBCI perhaps sweetens the deal price a bit but will still retain a significant fraction of the improved terms to reduce any dilution or to increase earnings.
I believe acquisitions will be a powerful earnings driver since there are probably a number of small banks in the GBCI trading area that will see GBCI as a quality acquirer after an absence of opportunities
in the last several years. And it may be an opportunity to expand the GBCI trading area.Jul 10, 2013. 08:43 AM | 1 Like |Link to Comment


text:
Rusty LaRue
Position: Point Guard ▪ Shoots: Right
Height: 6-2 ▪ Weight: 210 lbs.
Born: December 10, 1973 in Winston-Salem, North Carolina
High School: Northwest in Greensboro, North Carolina
College: Wake Forest University
NBA Debut: November 20, 1997
D-League: 53 G, 11.2 PPG, 2.4 RPG, 2.5 APG (Full Record)
Other Pages: College Basketball Stats
Promote your website or business by sponsoring this page for $10 on Basketball-Reference.com. Your message will replace this ad.


text:
Royalty rules the day as Sequim Irrigation Festival court is crowned
Dave Logan/for Peninsula Daily News
Peninsula Daily News
Print This | Email This
Most Popular this week
Port Angeles man, 61, crosses Strait on waterski but cancels return trip citing dangerous conditions
Want more top stories? Sign up here for daily or weekly newsletters with our top news.
Last modified: March 03. 2014 9:42AM


text:
The Dresden Files: Fool Moon
Inexact title. See the list below. We don't have an article named TheDresdenFiles/FoolMoon, exactly. We do have:
- Awesome/Fool Moon
- Funny/Fool Moon
- Heartwarming/Fool Moon
- Literature/Fool Moon
- NightmareFuel/Fool Moon
- ShoutOut/Fool Moon
- YMMV/Fool Moon
If you meant one of those, just click and go. If you want to start a TheDresdenFiles/FoolMoon page, just click the edit button above. Be careful, though, the only things that go in the Main namespace are tropes. Don't put in redirects for shows, books, etc.. Use the right namespace for those.


text:
Weaver Trailhead Back Cinch Only
We're Sorry ...
The item Weaver Trailhead Back Cinch Only, item code:WV00450R, has been discontinued or is no longer available.
You can navigate to other similar products like this by using the breadcrumbs OR shop other similar products like this one by using the tabs below.
Durable Back Cinch!
The Weaver® Trailhead Back Cinch Only is part of the Trailhead Collection. This collection is handcrafted from skirting leather that is finished to a mahogany color that matches the industry's most popular trail saddles. Each product is durably constructed and designed for reliability, beauty and value that will endure.
This back cinch is designed from a durable single-ply, 1 3/4" leather and includes the back cinch only, along with nickel plated hardware.
The Weaver® Trailhead Back Cinch Only offers:
- Company Info
- About Equestrian Collections
- About our Website
- 100% Satisfaction Guarantee
- Customer Testimonials
- eCatalogs
- Home
- Rewards Program
- Join the Mount Up to Rewards Program
- Rewards for You
- Affiliate Program
- Become an Equestrian Collections Affiliate
- Sponsorships & Fundraising
- Terms of Use
- Privacy Policy
- Terms of Use
- Help
- My Account
- Order Tracking
- Returns and Exchanges
- Shipping Info
- Sitemap
- We Care
- Eco-Conscious Products
- No Paper Catalogs - Save Trees
- Customer Service
- Toll Free: (877) 872-4415
- Help Section
- Contact Us


text:
View christian Singles in Geneva
By clicking continue, I agree to receive transactional and promotional emails from Match.com. I understand that I am free to withdraw consent at any time.
By using our site, you agree to the Match.com Terms of Use.
24 - Geneva, FL
Active over 3 weeks ago
39 - Geneva, FL
Active over 3 weeks ago
33 - Geneva, FL
Active over 3 weeks ago
29 - Geneva, FL
Active within 3 days
Match.com is the best place to search The Sunshine State for online singles. We prove that an online dating personals site can really lead to a long-lasting sincere relationship. With nearly 26 million members, someone's sure to catch your eye. Subscribe to Match.com in Geneva, Florida, and start e-mailing your personal fave personal ads right now.
Alafaya, Aloma, Altamonte Springs, Azalea Park, Cassadaga, Casselberry, Christmas, Chuluota, DeBary, Deltona, Eatonville, Edgewater, Enterprise, Fern Park, Forest City, Goldenrod, Heathrow, Lake Forest, Lake Helen, Lake Mary, Lake Monroe, Lockhart, Longwood, Maitland, Mid Florida, Mims, Oak Hill, Orange City, Orlando, Osteen, Oviedo, Sanford, Scottsmoor, South Creek, Titusville, Union Park, Ventura, Wekiva Springs, Winter Park, Winter Springs view all states »
Asian , Black , Catholic , Christian , Divorced , Free Online Dating, Gay Singles, Gay Dating, Jewish , Lesbian Singles, Single Parents, view all communities »


text:
Heatwave Pass is the ultimate DVD site for niche and fetish lovers. With over 1,500 DVDs, you get instant access to a huge library of specialized content that you wont find anywhere else.Visit Heatwave PassMore from Fuckin At 50
Old Grandma Strips Down And Rides A Young Stud
The following tags exist in this scene. You can find similar scenes by combining tags in this scene together using the checkboxes, or just click a tag name to browse...
Channel: Fuckin At 50
Do you recognise pornstars in this scene? Begin typing a pornstar name, then click on the button to suggest them!
He even spreads her ass cheeks open with his hands and sticks a thumb in her tight, puckered asshole
Grandma gets her granny pussy fucked hard by her grandsons bestfriend in the living room ending with a facial
Featured in playlists: Hey My Grandma is a Whore (53 Videos), Granny's and more (89 Videos), grannys (142 Videos), fav (120 Videos), grannylust (73 Videos)
Video Suggestions
- 16:43Fat Iren With Huge Teats Get Fucked By Manual CarlosMar 29, 2014
- 28:36Ebony Grandma Sarah Gets Fucked By Joe KwelJan 4, 2014
- 25:04Naughty MILF Karla Puts The Mature In AmatureAug 14, 2013
- 29:16Mature Chubby Chick Takes On Two DicksDec 4, 2013
- 26:21Busty Old Women Fucked Hard In CarApr 15, 2009
- 28:08Agnes Teases Gabor With Her Soft Skin And Big TittiesMar 15, 2014
- 19:50Older Man Nails His 19 Year Old Asian BabysitterAug 11, 2011
- 21:50Mature Whore Fucks Younger Guy On BedApr 19, 2014
- 15:53Dallas And Blue Iris Treat A Lucky Man To Some Hot PussyJul 19, 2014
- 24:42Sexy Redhead Andrea Loves Her Young StudAug 14, 2013


text:
U.S. Bank Garden Grove Branch
12112 Valley View Street, Garden Grove, CA 92845Get Directions
Branch Phone Number 714-622-1770 not available
Let Us Help You Choose a New Account
Tell us what type of account you'd like help with, and get matched with a personalized savings, checking, CD or mortgage account.
Did You Know
You can set personal preferences at your bank's ATM so it won't ask you things like what language you prefer or if you need a receipt.
3 Comments Is this review helpful?
Are you a customer of this branch? Share your experience.


text:
You are using an outdated browser. Please upgrade your browser to improve your ReverbNation experience.
"Charlie Let me know when you're ready for exposure on Phresh N Phamous Radio! I've done interviews with Big Sean, Jhene Aiko & more with over 22,000 nationwide listeners."
© 2015 eMinor Incorporated
All trademarks are the property of the respective owners. ReverbNation is not affiliated with the trademark owners.
Not listening to anything?
Try one of the ReverbNation Channels


text:
Please note:
We are on our vacation from August 20th to October 30th , 2015.
We do not make any shipments during this time. All orders making during this time will be shipped out on November 1st. We apologize for the inconvenience. Your business is always appreciated.
Coby Farm
THE EXTRACT OF NUX VOMICA - The true old time formula
Nux vomica is the most used pointing product in the world. This product has benn tried and tested for decades in every type of heel, in every type of competition.
Nux vomica as a poiting aid when given the last 3 days of the keep provides a powerful appetite stimulant when coupled with diet this makes sharper birds.
Nux Vomica is often misunderstood as a stimulant - what this cardiac stimulant dies is basically keeps the heart beating at a steady pace, Period. Look at the benefits of that statement. By keeping the heart beating at a steady pace, there is a little chance of shock setting in - No wonder Nux vomica is still used as the #1 pit aid after more than a century.


text: Andrew Redington/Getty Images [ Buzzer Beaters: First Day of the Masters, Harang Goes to Seattle and More By Chris Chaberski April 11, 2013 Today's top sports stories: Read More|Comment Category: National News, Sports Tags: Sports Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


text:
- Age / Gender:
- n/a, Male
- Location:
- Location not disclosed
- Joined:
- 8/5/05
- All Stats >
User Statshot
- Community Stats
Level 7 Gamer
Normal Whistle
Ranked as Civilian
Contact Info / Websites
Recent Game Medals
Egg Scrambler 10 Points Return the Phoenix Eggs to the Beastmaster doorway Medal Stats.
Phoenix Phreedom 25 Points Free the One-eyed Phoenixes from their cages Medal Stats.
Mini Michaelangelo 10 Points Carve a sculpture for the Pirate Medal Stats.
Medicine Mixer 10 Points Wake up Jorge the Drunk Medal Stats.
Wom-battler 25 Points Defeat the Blue Wombat Medal Stats.
Ork-estrated Attacker 25 Points Defeat the Yellow Ork Medal Stats.
Muncher Plague Eliminator 50 Points Sacrifice 3 XP Munchers on the Forest Altar Medal Stats.
Spinny Wrists 10 Points Learn to twirl your sword Medal Stats.
Son Savior 10 Points Return the missing boy to his parents Medal Stats.
Crabby Patty 25 Points Defeat the Ultra-Crab Medal Stats.
Total Medals Earned: 1,257 (From 166 different games.)
Favorite Audio
|-Space pirates-
|Techno Song
Favorite Movies
Favorite Games
Clicker Heroes Rated 4.2516 Stars An epic Clicker/Idle game with great production quality, graphics, and sound effects. Adventure - RPG Idle Evolution Rated 4.0998 Stars God did it in 6 days. How much time will you need? Strategy - Other Sky Quest Rated 4.3001 Stars Side shooter RPG. Gain skills, level-up and kick asses! Adventure - RPG Upgrade Complete 2 Rated 4.4422 Stars An upgrade to the previous game about upgrades. Upgraded in various upgradeable ways! Action - Shooter - Vertical Flight


text:
Rio Tinto Jobs in Denver, CO
No jobs found – change your filters above for more results
Rio Tinto Photos
Rio Tinto Reviews
"Rio Tinto Minerals in Denver- all kinds of bad "
Doesn't RecommendNeutral OutlookNo opinion of CEO
- Work/Life Balance
- Culture & Values
- Career Opportunities
- Comp & Benefits
- Senior Management
I worked at Rio Tinto full-time (More than a year)
Very good benefits. Pay is amazing if you're in a management role, otherwise it is a little higher than market.
The corporate structure is quite bureaucratic: there are a lot of check boxes to fill, but otherwise leaders don't do anything. If you are applying for a managerial role and you are lazy, this is the perfect place for you. You can sit back, not care about your company or your people, and as long as you stick around, you'll keep moving up and making more money. If you're starting from the bottom, driven and hard working with the thought that it will take you places, it won't. Expect to be taken advantage of without an awesome bonus that all the lazy people around you get to enjoy. The only thing that is rewarded is time; all that matters is how long you have been with the company, not what you contribute. So stop caring, sit back, and let yourself waste away and you'll do great!
Advice to Management
Keep praying that US Borax doesn't get divested because you'll never be able to replace your pay with the lack of skills you possess.


text:
|Company News
Possibly the world's most elaborate touring vehicle has just gone on sale in Dubai.
Can't get by with just a tent? Then welcome to the EleMMent Palazzo, which comes in at a little over $3m.
For that princely sum, you can have your very own gold-plated motorhome, which comes equipped with an onboard fireplace, an opulent master bedroom, an all-white leather lounging area. There's also a rooftop terrace thrown in, to boot.
The vehicle is 40ft in length and can automatically self wash after a drive through the desert.
The interior can transform in the evenings into a lounge, with dimmed marble lighting, a cutting-edge pop-up bar and a built-in floor-heating system.
The EleMMent Palazzo, which has been built by German-Austrian manufacturer Marchi Mobile, is available in gold silver and signature white but can be tailor made and painted according to its owners wishes.
Disclaimer:The view expressed here by our readers are not necessarily shared by Arabian Business, its employees, sponsors or its advertisers.
Please post responsibly. Commenter Rules
Dubai's next top gadget... submersible island yachts
Kokomo Ailand would perfectly fit to the wealthy Dubai lifestyle...
Gulf Craft impresses at Monaco Yacht Show
UAE-based shipyard displayed its largest superyacht at Europe...
Titanic II replica ship to make maiden voyage to Dubai, says Australian backer
Businessman Clive Palmer says the ship will be launched...
Mercedes-Benz mulls driverless-limo service
Autonomous fleet is 'concrete goal' for company, says Daimler...
Qatari supercars in Beverly Hills street race
Driver claims diplomatic immunity and avoids arrest
5 tips to make sure your car doesn't end up like this...
Essential pointers for taking care of your car during the...
The spirit of ecstasy
The Rolls-Royce Ghost is everything you expect from this...


text:
Hotel Du Sablar
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
How has this hotel rated in the past?
Travelers also recommend:
TripAdvisor Reviews Hotel Du Sablar Mont-de-Marsan
Travel Blogs from Mont-de-Marsan
Boredom and Annoyances
... to kill. I read a bit and wrote a bit and took a nap. So, there isn't much to talk about today because we didn't do much! In the evening, we made our gourmet dinner of instant rice and canned vegetables. Sometimes, you just have to work with what you've got, and sometimes, that isn't a lot. When we were just starting to get ready for bed around 8:30, a family of five "pilgrims" showed up at the refuge: the mother, the father, ...
Magnolias and Palm Trees
Day 44-
We started off together as three today with plans to walk 15km. My pace was still slower than usual, but much better than the previous few days. I walked with the teacher for most of the day while the architect walked ahead and waited for us to catch up at certain points. It was a beautiful day today with the promise to be quite hot in the afternoon. However, the morning walk was nice.
In Audignon, we stopped at the local church, where there was ...
The Route 66 and Orangina
... I gave the bar owner instructions to tell them that I had stopped there. Yet, as I exited, they were just walking up. They said that they had been worried about me, but I assured them all was well. The original plan had been for me to walk alone at my pace and meet them later, but the teacher insisted on walking with me, while the architect continued on. He said he also wanted to walk slowly today, but I suspect that he was just going to keep an eye on ...
Mr. Frodo and Vikings
... and he had been her only companion. So now, she's alone on the road. She travels to many different countries, and meets new people every day. She laughs a lot, and was very kind to me. I am glad that I met her.
We arrived in town at about 8:45am, but the refuge was not open. I said goodbye to the hostess and waited on the steps to the refuge for an hour when the cleaning lady let me into the building. I spent a few hours totally ...
Soup and Storms
... so we felt comfortable enough to make our small dinner of soup, bread, and cheese. Dinner conversation was fun and made up for the lack of food and the unsatisfactory surroundings. We have another far walk tomorrow, and I am hoping that a good night's sleep (in this not so comfortable bed) will help with the soreness in my feet.
Total distance walked today: 37km
Total distance walked during pilgrimage: ...


text:
NYC Parks Events Calendar
Get up, get out, and do something! Just about any day of the year, you can find something fun, informative, and healthy to enjoy at an area park. Feel free to browse the listings below, or use the search tools to find an event that matches your interests and location.
Viewing 14,651–14,660 out of 16,536 events
from October 5, 2012 (x) to April 25, 2026
Friday, November 13, 2015
External Forces: An Exhibit by Artist Sarah Yuster
at Conference House Park Visitor Center (in Conference House Park), Staten Island
10:00 a.m.–5:00 p.m.
This series of oil paintings by artist Sarah Yuster depicts artists in situ at various Staten Island locations, specifically preserved natural areas and parks.
Category: Art, Seniors
Children's Story Time & Art
at Poe Park Visitor Center (in Poe Park), Bronx
10:00 a.m.–10:30 a.m.
Enjoy interactive story time with songs, nursery rhymes, stories, and poems for toddlers and preschoolers.
Category: Kids
Exhibition: Alice Austen Everyday: A Photo Series Inspired by Place
at Alice Austen House Museum (in Alice Austen Park), Staten Island
11:00 a.m.–5:00 p.m.
Alice Austen's beloved home, Clear Comfort, was her muse and her window onto the world at the entrance to the New York Harbor. The vantage point from Clear Comfort is…
Exhibition: Becoming Clear Comfort: History of a Landmark
at Alice Austen House Museum (in Alice Austen Park), Staten Island
11:00 a.m.–5:00 p.m.
Alice Austen House's 30th Anniversary exhibition brings to light the history of the museum's National and New York City Landmark building, tracing its path from one-room…
Category: Art, History
Seasonal Crafts
at Poe Park Visitor Center (in Poe Park), Bronx
2:00 p.m.–3:30 p.m.
Make seasonal and holiday arts & crafts items to take home.
Category: Arts & Crafts, Kids
NYC SPARX: Technology and Dance for Girls
at St. Mary's Recreation Center (in St. Mary's Park), Bronx
2:00 p.m.–6:00 p.m.
Girls ages 12-17 will learn coding, tinkering, app building, technology and get homework help and college prep in this free program.
Category: Education, Kids
Kids Art Class
at Poe Park Visitor Center (in Poe Park), Bronx
2:30 p.m.–3:45 p.m.
Learn drawing and painting techniques using multiple mediums.
Category: Art, Kids
Teen PASS
at Faber Park Field House (in Faber Pool and Park), Staten Island, Red Hook Recreation Center (in Red Hook Recreation Area), Brooklyn
3:00 p.m.–6:00 p.m.
When school is out, Teen PASS offers FREE, exceptional clubs that focus on the areas of NYC Parks, arts, environmental science and sports that are tailored to the interests and talents…
Category: Education, Kids
3 to 6 Club
at Walker Park, Staten Island
3:00 p.m.–6:00 p.m.
Walker Park is offering various activities at the 3 to 6 Club, open to children ages 7 through 12 years, including art, literacy and sports.
Category: Kids
Go Girl Athletics
at St. Mary's Recreation Center (in St. Mary's Park), Bronx
4:00 p.m.–6:00 p.m.
Girls ages 12-17 years are invited to practice and improve their athletic skills by combining cardio and weight training to improve strength and flexibility along with cardio endurance.
Category: Kids, Sports
Pages:< Prev1…1463146414651466146714681469…1654Next >
Related Information
- Get information on upcoming events directly in your inbox by signing up for our Email Newsletters.
- Know about an event that's not on the calendar? Send us a tip!
- Planning an event and considering hosting it in a park? Make sure to read our Planning an Event page.


text:
PARIS, May 25 /PRNewswire-FirstCall/ -- Abbott (NYSE: ABT) today announced new data from the landmark EVEREST II (Endovascular Valve Edge-to-Edge REpair STudy) trial, which provide additional details about the safety and clinical benefit of Abbott's investigational MitraClip® system for the two causes of mitral regurgitation (MR) – functional MR (FMR) or degenerative MR (DMR). In the EVEREST II trial, the 30-day major adverse event rate in the MitraClip arm was similar for the FMR and DMR patient subgroups (8.2 percent for FMR patients, 8.1 percent for DMR patients), both lower than the surgical control group (42.6 percent). The MitraClip system also demonstrated consistent results in both FMR and DMR patients with both subgroups showing significant improvement at one year from baseline measures of heart function, symptoms and quality of life. These results were presented today during the Late Breaking Registries and Clinical Trial Updates session at the EuroPCR 2010 conference, and build upon the positive EVEREST II primary endpoint results that were presented during the American College of Cardiology 2010 meeting in March.
MR is the most common type of heart valve insufficiency and occurs when the leaflets of the mitral valve do not close completely, causing blood to flow backwards into the left atrium of the heart during the cardiac cycle. When patients are diagnosed with MR, they are usually classified as having functional MR or degenerative MR. Functional MR accounts for the majority of MR patients, and occurs due to heart muscle abnormalities caused by coronary artery disease or cardiomyopathy (a condition which causes the heart muscle to weaken). Degenerative MR is caused by deterioration of valve tissue.
|SOURCE Abbott
Copyright©2010 PR Newswire.
All rights reserved


text:
|Home | About | Journals | Submit | Contact Us | Français
Early adolescence is a time of rapid change in neuroanatomy and sexual development. Precision in tracking changes in brain morphology with structural MRI requires image segmentation with minimal error. Here, we compared two approaches to achieve segmentation by image registration with an atlas to quantify regional brain structural development over a 7-month interval in normal, early adolescent boys and girls. Adolescents were scanned twice (average interval=7.3 months), yielding adequate data for analysis in 16 boys (baseline age 10.9 to 13.9 years; Tanner Stage=1 to 4) and 12 girls (baseline age=11.2 to 13.7 years; Tanner Stage=3 to 4). Brain volumes were derived from T1-weighted (SPGR) images and dual-echo Fast Spin-Echo (FSE) images collected on a GE 3T scanner with an 8-channel phased-array head coil and analyzed by registration-based parcellation using the SRI24 atlas. The "independent" method required two inter-subject registrations: both baseline (MRI 1) to atlas and follow-up (MRI 2) to the atlas. The "sequential" method required one inter-subject registration, which was MRI 1 to the atlas, and one intra-subject registration, which was MRI 2 to MRI 1. Gray matter/white matter/CSF were segmented in both MRI-1 and MRI-2 using FSL FAST with tissue priors also based on the SRI24 atlas. Gray matter volumes were derived for 10 cortical regions, gray+white matter volumes for 5 subcortical structures, and CSF volumes for 4 ventricular regions and the cortical sulci. Across the 15 tissue regions, the coefficient of variation (CV) of change scores across individuals was significantly lower for the sequential method (CV=3.02), requiring only one inter-subject registration, than for the independent method (CV=9.43), requiring two inter-subject registrations. Volume change based on the sequential method revealed that total supratentorial and CSF volumes increased, while cortical gray matter volumes declined significantly (p<.01) in anterior (lateral and medial frontal, anterior cingulate, precuneus, and parietal) but not posterior (occipital, calcarine) cortical regions. These volume changes occurred in all boys and girls who advanced a step in Tanner staging. Subcortical structures did not show consistent changes. Thus, longitudinal MRI assessment using robust registration methods is sufficiently sensitive to identify significant regional brain changes over a 7-month interval in boys and girls in early adolescence. Increasing the temporal resolution of the retest interval in longitudinal developmental studies could increase accuracy in timing of peak growth of regional brain tissue and refine our understanding of the neural mechanisms underlying the dynamic changes in brain structure throughout adolescence.
Adolescence is associated with continued growth of head size and substantial changes in regional brain structure. Over the last two decades, quantitative cross-sectional studies using structural magnetic resonance imaging (MRI) revealed a curvilinelar developmental trajectory of cortical gray matter with an increase from birth to about 10 years of age followed by a continuous decline through adulthood to old age (Bartzokis et al., 2001; Blanton et al., 2001; Blatter et al., 1995; Caviness et al., 1996; Courchesne et al., 2000; De Bellis et al., 2001; Giedd et al., 1996a; for reviews Giedd et al.; Giedd et al., 1996b; Gogtay et al., 2004; Jernigan et al., 2001; Jernigan and Tallal, 1990; Kennedy et al., 1998; Lange et al., 1997; Paus et al., 1999; Pfefferbaum et al., 1994; Raz, 2004; Raz and Rodrigue, 2006; Reiss et al., 1996; Sowell et al., 1999; Sowell et al., 2002; Stiles and Jernigan; Tisserand et al., 2002). A further theme of these studies was the presence of age-related differences in regional brain volumes, suggesting a posterior-to-anterior developmental order. Verification of these cross-sectional data and speculations required longitudinal study to calculate true developmental trajectories and individual differences by brain region and tissue type (Giedd et al., 1996a).
In general, prospective longitudinal studies (reviewed in Paus, 2010) have verified cross-sectional observations and have provided the essential data to model developmental trajectories of regional brain growth. In particular, developmental patterns derived from longitudinally-acquired T1-weighted MRI data indicate heterochronicity and trajectory differences by brain region and sex (Giedd et al., 1999; Lenroot et al., 2007; Sowell et al., 1999; Sowell et al., 2004b). The brain size of boys is typically upwards of 10% larger than that of girls (Dekaban and Sadowsky, 1978; Goldstein et al., 2001). Brain growth in girls starts and ends earlier than that in boys, peaking at 10.5 years in girls and 14.5 years in boys and declining thereafter (Lenroot et al., 2007). Regionally, the neocortex follows a curvilinear trajectory (Gogtay et al., 2004; Lenroot et al., 2007; Shaw et al., 2008), whereas allocortex and medial temporal structures follow a linear path (Gogtay et al., 2004). Growth in cortical regions is earlier for both sexes in posterior cortical than anterior regions, being about 7 to 10 years in occipital and parietal cortices and 10 to 13 years in frontal regions (Shaw et al., 2008).
While trajectories of growth curves provide a basis for estimating peaks in growth, the accuracy of the estimates is limited by temporal resolution of the measurements. The test-retest interval used in the large-scale longitudinal NIMH study of brain development, focused on ages 3.5 to 33 years old, is 2 years (Giedd et al., 1999; Giedd et al., 1996a). The cohort of Sowell and colleagues (e.g., Sowell et al., 2004a; Sowell et al., 2002) was also scanned at 2-year intervals and focused on development of regional cortical thickness and presented novel findings on continued gray matter thinning of cortical language areas associated with vocabulary scores, an index of language development (Sowell et al., 2004a). Likewise, the NIH MRI study of normal brain development uses 2 year intervals for ages 7 days to 18.3 years old but introduced intervals as close as 3 months for children ages 7 days to 4.5 years to improve modeling of development during these years of rapid change (Evans, 2006).
These childhood-to-adolescent years also mark advancement through puberty and its plethora of sex-specific hormonal changes that influence physical growth and maturity not only in physiognomy but also in brain morphology. Despite the likely linking of pubertal and brain structural development, few MRI studies provide information about pubertal staging at times of study (cf., Blakemore et al.). Those that have used schedules of pubertal development, such as Tanner staging (Tanner, 1962), or direct measurement of sex hormones report mixed results, with some [MRI: (Neufang et al., 2009; Peper et al., 2009a)] but not others [sleep electrophysology: (Feinberg et al., 2006)] finding staging or hormonal levels to be predictive of changes in brain structure or presumed associated function. Whether brain structural changes are great enough for detection with conventional MRI over about half-year intervals in young adolescents has not been tested and therefore never linked to active pubertal advancement.
Accordingly, this study focused on change in regional brain volumes over an average of 7 months in adolescent boys and girls and identification of image quantification approaches that would be sensitive yet robust enough to detect changes reliably over this short interval. To calculate volume change using atlas-based image segmentation with the SRI24 atlas (Rohlfing et al., 2010), two principal image registration approaches were tested. The "independent" method required two inter-subject registrations to the atlas: both baseline (MRI 1) to the atlas and follow-up (MRI 2) to the atlas. The "sequential" method required one inter-subject registration, which was MRI 1 to the atlas, and one intra-subject registration, which was MRI 2 to MRI 1. We tested the hypothesis that the sequential approach for quantifying regional volume change would yield lower coefficients of variation (CV) of change scores across individuals than the independent method, rendering differences more reflective of true developmental effects rather than misregistration. Considering known growth patterns (Lenroot et al., 2007; Sowell et al., 2004a), we predicted that 1) cortical tissue volumes would decline, 2) ventricular and cortical sulcal volumes would expand, and 3) the sequential method of registration would detect these changes more readily than the independent method. As a test of convergent validity of the method, changes in regional brain volumes using each registration approach were correlated with changes observed in Tanner stages.
Adolescents (11 to 14 years old) were recruited from the local community through flyers, word of mouth, and through advertisements placed in local school newsletters. Following school newsletters and with the approval of the administrations of each school, sleep laboratory staff gave a brief presentation to the adolescents during school time. The study was approved by the IRB at SRI International. Parents gave informed written approval for their children to participate and the children gave assent to participate in this longitudinal study. The procedures described next were conducted at the baseline visit and at follow-up, which occurred on average 7.3 months later (range=4 to 10.7 months).
At their initial and follow-up visits, parents and their children were interviewed by a laboratory research psychologist or other trained researcher using a structured interview (Kiddie Schedule for Affective Disorders, K-SADS) to assess current and lifetime history of psychiatric disorders (Kaufman et al., 1997). Using the probe questions of K-SADS-PL, the interviewer questioned each participant about age at first regular use of alcohol or drug and recency and frequency of use for each substance. No participant endorsed regular use of alcohol or any substance at baseline or follow-up. One parent of each child was also interviewed at each session and confirmed, without knowledge of the child's report, a negative history of regular alcohol and drug use. No further information on alcohol or drug misuse was obtained because there were no endorsements of gate (i.e., probe) questions. Other exclusionary criteria were history of loss of consciousness > 30 minutes or central nervous system diseases. Parents provided information to determine socioeconomic status (Hollingshead, 1975). Intelligence quotient (IQ) of each adolescent was measured with the Peabody Picture Vocabulary Test (Dunn and Dunn, 1997).
The adolescents were given the self-administered rating scale for pubertal development (Carskadon et al., 1993). Pubertal category scores for boys were based on body hair growth, voice change, and facial hair growth. Scores for girls were based on body hair growth, breast development, and menarche. Boys and girls were classified as pre-pubertal (Tanner 1), early pubertal (Tanner 2), mid-pubertal (Tanner 3), late pubertal (Tanner 4), or post-pubertal (Tanner 5) (Carskadon and Acebo, 1993), with stages in our sample ranging from 1 to 4. Demographic data appear in Table 1.
MR data were collected on a GE 3T Signa scanner with an 8-channel phased-array head coil. Brain volumes were derived from T1-weighted Inversion-Recovery Prepared SPoiled Gradient Recalled (SPGR) images (TR=7 ms, TE=2.2 ms, TI=300 ms, thick=1.25 mm, skip=0 mm, 124 slices, scan time=9:43 min) and dual-echo Fast Spin-Echo (FSE) images (TR=8583 ms, TE=13.5/108.3, thick= 2.5 mm, skip=0 mm, 62 slices).
All acquired structural images were first corrected for intensity bias by applying a second-order polynomial multiplicative bias field computed via entropy minimization (Likar et al., 2001). The late-echo FSE image was corrected using the bias field computed from the corresponding early-echo image to maintain the ratio of early- and late-echo values at each pixel, which keeps quantities derived from this ratio (e.g., T2) invariant. For each subject and each session, the bias-corrected early-echo FSE image was then registered to the bias-corrected SPGR image using intensity-based nonrigid image registration (Rohlfing and Maurer, 2003) (http://nitrc.org/projects/cmtk). The SPGR, early-echo FSE, and late-echo FSE images were each skull stripped using FSL's Brain Extraction Tool, BET (Smith, 2002). The early- and late-echo brain masks were reformatted into SPGR image space and combined with the SPGR-derived brain mask via label voting (Rohlfing and Maurer, 2005) to form the final SPGR brain mask.
For each subject, the skull-stripped baseline and follow-up SPGR images were each registered to the SPGR channel of the SRI24 atlas (Rohlfing et al., 2010) (http://nitrc.org/projects/sri24) via nonrigid image registration (Rohlfing and Maurer, 2003). We chose the SRI24 atlas over other available brain templates (e.g., MNI152) because of its ability to discern detailed anatomical structures, which can thus be unambiguously outlined directly in the atlas images without the need to access the images that were used to create the atlas itself. Independent cortical and subcortical parcellation maps for baseline and follow-up images were obtained by reformatting labels maps defined in SRI24 directly into baseline and follow-up SPGR image spaces using the subject-to-atlas coordinate transformations.
The unstripped but bias-corrected follow-up SPGR image for each subject was then registered to the unstripped and bias-corrected baseline SPGR image. Sequential parcellation maps for the follow-up SPGR images were obtained by reformatting the SRI24 labels maps using the concatenation of follow-up-to-baseline and baseline-to-atlas transformations.
The rationale for using direct transformations to parcellate the baseline images, but concatenated transformations to obtain follow-up parcellation maps is the inevitable presence of registration errors. Because subject-to-atlas (i.e., inter-subject) registration is a relatively more difficult computational problem than within-subject longitudinal registration, we expected registration errors to be more severe in the former than the latter.
Thus, although the use of a concatenated transformation to parcellate the follow-up data does not eliminate subject-to-atlas registration errors, we ensure that the same errors apply to baseline and follow-up data consistently, which would not be the case if the follow-up data were registered to the atlas independently. Because we are primarily interested in measuring longitudinal effects, longitudinal consistency of registration errors should be beneficial. Finally, as a test of the robustness of the sequential approach we reversed the inter- and intra-subject chain and reformatted the SRI24 labels maps for the baseline images using the concatenation of baseline-to-followup and followup-to-atlas transformations.
All bias-corrected and skull-stripped SPGR images were segmented into three tissue compartments (gray matter, white matter, CSF) using FSL's FAST tool (Zhang et al., 2001). As tissue priors to both initialize and guide the classification, we used the tissue probability maps provided with the SRI24 atlas, reformatted into subject SPGR space via the same transformations described above for the independent atlas-based parcellation.
This analysis focused on major lobar tissue regions of the cortex, allocortex, and subcortical structures. Accordingly, the 116 ROIs available from the SRI24 atlas, derived from the Automated Anatomical Labelling (AAL) template (Tzourio-Mazoyer et al., 2002) were collapsed into 15 bilateral ROIs (Figure 2). The decision to collapse the 116 ROIs into 15 was motivated by considering the proportion of ROIs (N=15) to subjects (N=28) and confirmed by the use of these 15 ROIs in our studies of cerebrovascular perfusion (Pfefferbaum et al., 2011; Pfefferbaum et al., 2010). A further consideration was the desire to have anatomically-driven tissue subregions, and not simply gross lobar volumes, that were of similar size for statistical comparability. For each subject and time, gray matter volume was computed for each cortical region, and tissue volume for each subcortical region. Also measured were CSF-filled volumes of the lateral ventricles, third ventricle, temporal horns, cortical sulci, and sylvian fissures, based on ROIs drawn also on the SRI24 SPGR template (Figure 3) and reformatted into subject image space. The ventricles were identified by registration, and for the cortical sulci and sylvian fissure, the CSF segmentations from FAST were multiplied against the ROIs in Figure 3.
We estimated SNR, which could be diminished by subject movement, in a sample of highly coherent white matter in the centrum semiovale of the inner 55% of the supratentorium masked on the SRI24 atlas and applied to each individual's MRI at each session. This white matter region, which was approximately 110 cc volume across subjects, began inferiorly at midpons, extended superiorly to the superior reaches of the centrum semiovale, just inferior to the cortical gyri and sulci, and medially to the sylvian fissures and excluded the corpus callosum. To further ensure homogeneity of tissue, the region was also masked by each individual scan's white matter segmentation. SNR was calculated as the mean divided by the standard deviation of the signal intensity of all voxels in this white matter sample.
Comparison of the two registration methods was based on differences between volumes at MRI 1 (baseline) and MRI 2 (followup) derived from each method. Because tissue volumes were predicted to decline and CSF volumes were predicted to increase, differences were tested with one-tailed paired t-tests and with family-wise Bonferroni correction; thus for 15 tissue ROIs, the critical p-value = .007, and for the 5 CSF volume ROIs, the critical p-value = .02.
Coefficients of variation (CV) of change scores across individuals were calculated for each ROI determined from each method, where the CV=SD/mean of the 15 tissue ROIs. CVs provide a measure of the dispersion of the values with respect to the mean expressed as a percentage and serve as an index of measurement precision. As such, the CV is an error estimate, which can reflect parcellation, registration, movement, and other sources of error. Mean CVs across the 15 tissue ROIs were derived for each registration method and compared with Wilcoxon tests. The same analysis procedure was conducted for CSF volumes of the ventricles and cortical sulci. The method with the lower CVs was then chosen to describe regional brain changes with development using paired t-tests or Mann-Whitney U-tests and Pearson correlations or Spearman rank order tests between change in regional brain volumes and change in Tanner stage.
Change measured in the 15 tissue ROIs revealed similar patterns regardless of registration method (Figure 4). For the sequential method, significant declines in volumes were present in five regions: lateral frontal (p=.0001), medial frontal (p=.0002), anterior cingulate (p=.01), precuneus (p=.0006), and parietal (p=.0001) cortices; the temporal cortex showed a trend (p=.02). For the independent method, significant declines in volumes were present in four regions: lateral frontal (p=.0005), medial frontal (p=.0063), precuneus (p=.0014), and parietal cortices (p=.0011).
Across the 15 tissue ROIs, the CV for the sequential method was 3.0% and for the independent method was 9.4%. This difference was significant with the Wilcoxon test (Z=2.953, p=.0031), favoring the sequential method. As a further test of the robustness of the sequential method, we reversed the temporal order of the intra-subject registration with the SRI24 atlas, so that the reformatting sequence was SRI24 - MRI 2 - MRI 1. The average CVs for this reversed sequence was 4.2% and also was significantly lower than that of the direct method (Z=2.272, p=.0231) but not significantly different from that of the forward sequential method (Z=0.568, p=.5701). The CVs for the ICV was 9.7% for both the direct and sequential methods.
For the sequential method in the forward direction, increases in the CSF-filled volumes were significant in four of the five ROIs: lateral ventricles (p=.0017), temporal horn (p=.0006), cortical sulci (p=.0001), and sylvian fissures (p=.0038); the enlargement of the third ventricle was not significant (p=.1300). For the independent method, although all CSF ROIs increased over time, three did so significantly: lateral ventricles (p=.0014), cortical sulci (p=.0030), and sylvian fissures (p=.0038); the enlargement of neither the third ventricle (p=.0420) nor temporal horns (p=.1971) was significant.
Although the mean CVs across the five CSF ROIs was lower with the sequential (2.1%) than independent (2.9%) method, this difference was not significant (Z=.405, p=.6858). Supratentorial volume showed a greater increase with the sequential method (mean±SD=12.23±13.11 cc, p=.0001) and lower CV (10.7%) than with the independent method (6.36±12.06 cc, p=.0095; CV=18.9%).
The SNR for each registration method at each MRI was about the same: MRI 1=10.58 and MRI 2=10.55 for the independent method; MRI 1=10.58 and MRI 2 =10.57 for the forward sequential method; and MRI 1=10.49 and MRI 2=10.55 for the backward sequential method. None differed significantly between scans within a method. Further, none of the SNR estimates correlated significantly with age, and none differed by sex.
Assuming that the CVs reflect measurement error, the results indicated that the sequential method (temporally forward) yielded lower error than the independent method in longitudinal data analysis and thus was used in the remaining analyses to characterize developmental change in regional brain volume over the rescan interval. ROIs exhibiting significant volume changes from MRI 1 to MRI 2 are presented as "spaghetti" plots (Figures 5–7 and Table 2).
The supratentorial volume increased about 1.0% (p<.0001). The average supratentorial volume of the boys was larger than that of the girls at both MRIs (p=.0001), but percentage volume change (boys=1.0% vs. girls=0.8%) was not related to sex (t(26)=6.97, p=.49) or BMI (r=−.22, p=.25). Similarly for the tissue and CSF ROIs, the boys generally had larger volumes than the girls, but there were no significant differences between boys and girls in percentage change for any of the 21 ROIs (the largest t-value=1.375, p=.1809).
Longer time between MRIs correlated with greater volume declines in several cortical gray matter ROIs: lateral frontal (r=−.44, p=.0202), precuneus (r=−.62, p=.0004), and parietal (r=−.43, p=.0239) volumes. Using multiple regression, we attempted to discern whether these relations were attributable to length of interval or to age at MRI 1 and found that interval length made an independent contribution to the volume changes (p=.0235 for lateral frontal, p=.0004 for precuneus, and p=.0264 for parietal volumes) over and above the contribution from age.
Longer intervals between MRI sessions could herald advance in Tanner stage. Of the 28 adolescents, 5 advanced by one step: 3 girls changed from 3 to 4, and 2 boys changed from 2 to 3. Consistent with the known developmental pattern, all 5 adolescents who advanced by Tanner stage showed volume loss in lateral frontal, anterior cingulate, precuneus, and parietal gray matter and expansion of the lateral ventricles and cortical sulci (Figure 8). Of these 6 regions, Mann-Whitney tests indicated a decline (one-tailed) in anterior cingulate (p=.0223) and precuneus (p=.0256) gray matter volume and an increase in cortical sulcal volume (p=.0223) in the 5 who changed compared with those who did not.
The results of this study provide evidence that longitudinal MRI assessment using robust registration is sufficiently sensitive to identify significant regional brain changes over about a half-year in boys and girls in early adolescence. The independent registration method used two inter-subject registration steps, whereas the sequential registration method relied on one inter-subject and one intra-subject registration. Reducing the number of inter-subject registrations minimized measurement error, as revealed by the lower CV for the sequential than independent methods, and likely enhanced detection of small volume changes occurring over short intervals. Consistent with current longitudinal studies based on longer follow-up intervals, the patterns of change differed by brain region. Specifically, developmental changes were greater in anterior than posterior cortex, suggesting remodeling of brain structure towards maturity (Gogtay et al., 2004; Sowell et al., 2004a). As with all in vivo imaging protocols, precision and registration are limited by the spatial resolution of acquired images, which in our case was about 1 mm3.
Adolescent neurodevelopmental trajectories show a dynamic, complex, and predictable change, with regionally different rises and falls in volume or cortical thickness notable in the age range between 7 and 18 years but with most changes occurring between 9 and 13 years. These neurodevelopmental trajectories were established from data typically collected at 2-year intervals (Lenroot and Giedd, 2010; Shaw et al., 2008), although the NIH-PD study adjusts its interval by age, where infants and children age 7 days to 4 years are scanned up to 5 times at 3 or more month intervals, whereas children to adolescents age 5–18 years are scanned 3 times in 2-year intervals (Evans, 2006). In the NIH-CHPB longitudinal study, Lenroot et al. (Lenroot et al., 2007) reported on 387 boys and girls and men and women, age 3 to 27 years, and showed that total cortical gray matter volume peaked at 10.5 years in girls and 14.5 years in boys. Cortical frontal gray matter volume of girls peaks about a year before that of boys (10.5 compared with 11.5 years of age). This sex-related difference in volume peak was slightly earlier than those reported in an earlier study from the same research group based on fewer adolescents for whom the peaks were at 11 years of age for girls and 12.1 years for boys (Giedd et al., 1999). Shaw et al. (Shaw et al., 2008) reported on 375 youth and adults of the NIH-CHPB cohort, age 3.5 to 33 years, and a total of 764 MRIs collected longitudinally at 2-year intervals. Age of peak cortical thickness of different frontal regions ranged between 9.6 years for precentral cortex to 13.8 years for the cingulate cortex. Cortical brain regions have characteristically different cell types and structures and followed different growth trajectories, for example, cubic for neo (iso) cortex and linear for allocortex. Our increased "temporal" resolution of image acquisition was sensitive enough to detect a 2% decline in anterior cortical volume. The implication of this ability suggests that narrowing the retest interval should increase accuracy in timing of peak growth of regional brain tissue and refine modeling of individual variability in the time and slope of regional neurodevelopmental trajectories notable in the "spaghetti" plots.
A robust factor in regional brain structural change in the present study was pubertal advancement as measured by self-reported Tanner staging. Advancing a step in Tanner stage heralded declines in lateral frontal, anterior cingulate, precuneus, and parietal gray matter volumes and expansion of the lateral ventricles and cortical sulci. Volume changes were uniquely related to scan interval rather than to age. Despite limitations of self-reported Tanner stage determination, this method is still considered valid (Duke et al., 1980) and a"gold standard" (Dorn et al., 2006). Although as noted by Luna et al. (Luna et al., 2010) the validity of self-reported Tanner staging can be affected by age, sex, ethnicity, race, and weight status (Bonat et al., 2002; Neinstein, 1982; Raman et al., 2009; Schlossberger et al., 1992), the young adolescents in the current study were of relatively high socioeconomic status, mostly Caucasian, and with normal BMI, factors that are associated with valid self-staging.
Other MRI studies accounting for pubertal development were cross-sectional. A VBM analysis of MRI data in 37 boys and 41 girls, age 10 to 15 years old, showed that smaller total gray matter volumes correlated with higher estradiol levels in girls, notably in prefrontal, parietal, and middle temporal cortices; sex hormone-MRI volume correlations were not forthcoming in the boys, likely because they were, on average, about a year younger than the girls (Peper et al., 2009a). A twin study of 210, 9-year old boys and girls (Peper et al., 2009b) provided strong cross-sectional evidence, based on VBM analysis, for an association between pubertal development in children with secondary sexual characteristic and those without them and the onset of decreasing gray matter in prefrontal and parietal cortical density. Another cross-sectional MRI study in 15 boys and 15 girls with Tanner stage information and circulating hormone levels revealed a complex set of relations involving medial temporal and diencephalic brain structures that suggested a role for sex hormones in influencing the organization of brain development (Neufang et al., 2009).
A number of factors can affect image quality and registration accuracy and ultimately increase measurement error. Church et al. (Church et al., 2010) reviewed problems of head size differences and movement in the scanner as common problems to overcome in acquisition and analysis. They note, for example, that although children have smaller heads and tend to move more in the scanner than adults, these problems can be minimized by registering brains of all ages (especially those at least 7 years old) to a common atlas. This approach also enables direct comparison of children and adults, at least within the older child/young adolescent to adult age range (Burgund et al., 2002). In the current study, we used the SRI24 atlas (Rohlfing et al., 2010) constructed from adult MRI data to register the adolescent MRI data, collected in 10 to 13 year olds, into common space, thus abiding one of the recommendations to minimize error from subject movement. In addition, we calculated SNR in the MRIs for each registration approach and found adequate SNR for each method that was not related to age or sex. The sequential registration approach could also apply to functional studies, which require registration across image modalities within subjects and to standard spatial coordinate systems (i.e., atlases) as well as accounting for developmental changes in structure (cf., Poldrack, 2010).
The repeated observation of the ontogenetic progression of posterior to anterior brain development has engendered the interpretation that frontal regions exhibit more active synaptic pruning than posterior regions during early adolescence (Feinberg, 1983; Huttenlocher, 1979, 1990). The active changes in anterior neocortex and allocortex may well parallel known developmental changes that occur in executive functions, including attention, behavioral regulation, judgment, and problem solving as adolescents progress towards adulthood (for review, Stiles and Jernigan, 2010). It is tempting to speculate that narrowing the retest interval would increase accuracy in timing of peak growth of regional brain tissue and refine our understanding of the neural mechanisms underlying the dynamic changes in brain structure throughout adolescence.
This work was supported by NIH grants AA016273, AA005965, AA017168, AG017919, EB008381.
Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Statement on conflict of interest Drs. Sullivan, Pfefferbaum, Rohlfing, Baker, Padilla, and Colrain have no conflicts of interest with this work, either financial or otherwise.
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's Canada Institute for Scientific and Technical Information in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


text:
MIAMI (AP) - A Brazilian Olympic freestyle skier who was on her way to competing at the Sochi Winter Games when she was paralyzed while training in Utah has completed her first week of rehabilitation in Miami.
In a statement released Thursday, Lais Souza said she's feeling better and ready to face the challenges ahead of her. She also expressed gratitude for the support she has received from around the world.
Souza participated in the 2004 and 2008 Summer Olympics as a gymnast before switching to the winter sport. Another Brazilian skier took her place in Sochi.
Souza injured her spine Jan. 27 when she hit a tree. The 25-year-old is being treated at Jackson Rehabilitation Hospital in Miami.
Hospital officials said Souza is learning to use an electric wheelchair.


text:
43 search results for Children's Hospital
Heather Graham joins Rob Corddry in 'Little In Common' pilot
Type: Article | Date: Thursday, Aug 25, 2011Texas-based comedy is from 'Party Down' creator Rob Thomas
Comic-Con fans can vote for which new 'Psych' episode to air
Type: Article | Date: Wednesday, Jun 26, 2013A midnight screening of 'Psych: The Musical' is also scheduled
'Real Housewives of Beverly Hills' recap: Can Brandi change?
Type: Post | Date: Tuesday, Jan 7, 2014Yolanda and Lisa defend Brandi, but should they?
Police: 12 dead, at least 50 injured in Colorado theater shooting
Type: Article | Date: Friday, Jul 20, 2012Midnight screening of 'The Dark Knight Rises' turns violent
Alyson Hannigan is sticking with CBS, joins comedy pilot 'More Time With Family'
Type: Post | Date: Friday, Feb 14, 2014Alyson Hannigan sticking with CBS, joins comedy pilot 'More Time With Family' Octavia Spencer to star in Fox pilot "Red Band Society" "American Idol" boss: We're not bringing back Simon Cowell
'The Big Bang Theory' and its fellow CBS Thursday shows could benefit from starting 6 weeks later
Type: Post | Date: Wednesday, Feb 5, 2014'The Big Bang Theory' and its fellow CBS Thursday shows could benefit from starting 6 weeks later "Ray Donovan" adds Hank Azaria and Sherilyn Fenn Clay Aiken already deleted controversial tweets ahead of his Congressional run
'Real Housewives of Beverly Hills recap: Kyle opens her store and confronts Kim
Type: Post | Date: Tuesday, Mar 12, 2013Kim explains why she seemed loopy in Paris
Watch: Kate Bosworth, Lake Bell, and Katie Aselton share 'Black Rock' memories
Type: Post | Date: Sunday, Jan 22, 2012We sat down with the director of the survival thriller and her co-stars
IMAX prologue to 'Star Trek Into Darkness' teases expertly and answers nothing
Type: Post | Date: Monday, Dec 10, 2012One thing's for sure: the chemistry is definitely in full force for the sequel
'True Blood,' 'Walking Dead' lead the Comic-Con 2011 Friday TV schedule
Type: Article | Date: Friday, Jul 8, 2011'Bones,' 'Torchwood,' 'Spartacus' and more will also hit San Diego


text:
BeneFit Cosmetics High Beam
1394 reviews
72% would repurchase
Package Quality: 3.5
Price: $$$
Package Quality: 3.5
Price: $$$
INGREDIENTSWater, Propylane Glycol, Sesame (Sesamum Indicum) Oil, Mica, Isopropyl Palmitate, Isopropyl Lanolate, Stearic Acid, Safflower (Carthamus Tinctorius) Oil, Glyceryl Stearate, Titanium Dioxide, Polysorbate 60, Cetyl Alcohol, Jojoba (Buxus Chinensis) Oil, Magnesium Aluminum Silicate, Corn (Zea Mays) Starch, Triethanolamine, Talc, Oleth-20, Iron Oxides, Lanolin Wax, Simethicone, Sorbitan Stearate, Cellulose Gum, Methylparaben Diazolidinyl Urea, Propylparaben, BHA.
on 5/11/2013 8:52:00 PM
Age: 19-24
Skin: Combination, Fair, Cool
Hair: Brunette, Other, Other
Eyes: Green
I had a sample of this before purchasing the full sized product and I loved it! I used it everyday on my brow bones, my cupid's bow and the tops of my cheeks. It gave a luminous iridescence without being obvious in any way. I found it was perfect for my very fair skin. However, I didn't get along with the product at all after I got the full size. Perhaps it was a change of formula or a change in my foundation routine but instead of going on smooth and silky it would drag along my foundation creating streaks of shine! I tried and tried with this product to get the results I used to but it just didn't work for me anymore. Disappointed.
on 5/9/2013 3:48:00 AM
Age: 25-29
Skin: Combination, Fair, Not Sure
Hair: Brunette, Other, Other
Eyes: Blue
Life changing. I use it right above my brow bones, where its most reflective. Committed for life.
on 5/6/2013 8:15:00 AM
Age: 30-35
Skin: Dry, Fair-Medium, Neutral
Hair: Brown, Other, Other
Eyes: Brown
It caused extreme swelling on me, I suggest making a patch test for girls with sensitive skin. Previously I has allergy to lancome absolue eye cream, both are containing triethalomine so it can be the cause.
on 4/25/2013 2:17:00 PM
Age: 18 & Under
Skin: Combination, Fair-Medium, Neutral
Hair: Blond, Straight, Fine
Eyes: Green
Don't usually buy high end products, like to stick to drugstore stuff but i have recently been receiving lots of Benefit products as gifts.
Really like this products-gives me a really nice radiant glow
Only complaint is once you've used up more than probably 2/3's it becomes an absolute nightmare to get enough out to use it
would pick Girl meets pearl over this because of that..
on 4/23/2013 12:47:00 PM
Age: 44-55
Skin: Normal, Fair-Medium, Cool
Hair: Brunette, Wavy, Fine
Eyes: Grey
Love this pink pearly highlighter. I tap it around the outside of my eye socket and down onto the top of my cheekbone. Brings attention to the shape of the face and eye. Really flattering.
on 4/21/2013 3:57:00 PM
Age: 18 & Under
Skin: Combination, Olive, Not Sure
Hair: Black, Other, Other
Eyes: Brown
Eh this highlighter was kind of a turn off for me.I've heard so much about Benefit High Beam and I owned it a couple of years ago but I wasn't really into highlighters then so I just gave it to my sister but currently I've been in love with highlighters so I tried High Beam out again. Its not a bad product I just don't like how its 26 dollars for an itty bitty bottle and its personslly too shimmery for my liking. Its not hard to blend but I think this will more suit pale skin tones rather than olive or dark skin tones because its a pink pearly color and its not really attractive on my skin tone. The staying power isn't fantastic either maybe because its a liquid? Not sure but it kind of faded within an hour for me.
on 4/17/2013 7:39:00 PM
Age: 25-29
Skin: Normal, Fair, Not Sure
Hair: Blond, Wavy, Other
Eyes: Green
I love this product! I dont really use highlighter too much, but this is really great to mix with foundation. to creat this look: mix one part liquid foundation (a thicker foundation works best) with one equal part high beam and apply as usual. It will give you a beautiful luminous glow. I have repurchased a couple times and will continue to do so.
on 4/15/2013 10:10:00 AM
Age: 19-24
Skin: Normal, Fair, Not Sure
Hair: Brunette, Other, Other
Eyes: Blue
I tried a load of highlighters before finding this one and now my quest for the perfect highlighter is over!
A small amount goes a long way, the product last ages without going clumpy!
Its easy to blend on top of foundation without wrecking your base
Its very subtle but when it catches the light it creates a beautiful glow
I prefer this too the moonbeam as it looks a lot more natural and has a better finish!
It works great on pale skin tones!
on 4/6/2013 11:07:00 PM
Age: 19-24
Skin: Combination, Other, Not Sure
Hair: Black, Other, Other
Eyes: Brown
This stuff is my favourite. It really has lasted me a long time, you only need to use a little! It's a bit pricey for $25 but it's totally worth it ! Would definitely buy again.
on 4/4/2013 6:33:00 AM
Age: 18 & Under
Skin: Normal, Medium, Not Sure
Hair: Brown, Other, Other
Eyes: Brown
Love this product it's my HG for highlighting in contouring , I think it leaves a sheer look on the face rather than a glittery look ! I like to use this under my eyes and on my cheek bones before and after foundation and then also on the bridge of my nose after foundation and also on the Cupid's bow ! Then I use bronzer to contour . I like the packaging but I am afraid of dropping it because it's made of glass , it's never leaked or anything though so it's all good :) the price is decent enough could be a little cheaper but what can you do ! All together a great product that I will definetley repurchase
Popular Highlighters
398 Reviews
450 Reviews
36 Reviews
17 Reviews
38 Reviews
29 Reviews
Video Reviews & Tutorials
Sephora Backstage: Carmindy's 5 Minute Face by SephoraEditor


text:
David de Gea played his first competitive match since May as Spain beat Macedonia, while Austria qualified in style for Euro 2016.
Are Wales really the 10th best team in the world? We analyse the FIFA world rankings to find out how it works…
Alvaro Morata scored as Spain beat Ukraine 1-0 in Friday's European Qualifiers, while Slovakia won to stay top of Group C.
Germany beat European champions Spain 1-0 in Tuesday night's friendly thanks to a late goal from Toni Kroos.
Spain took the first steps on the road to recovery from their World Cup woe with a 5-1 win over Macedonia in Valencia.
UEFA have approved the launch of a Nations League from 2018, with the new tournament to be played every second year.
Find out more about Sky Sports' live coverage of 250 European Qualifiers this season.
Romania pipped Turkey to second spot in Group D and a place in the World Cup play-offs by defeating Estonia 2-0.
Turkey won 2-0 in Estonia to move into second place in World Cup qualifying Group D.
San Marino claimed the first European Championship qualifying point in their history after a stalemate with Estonia.
Hungary moved into second place in their World Cup qualifying group with a comfortable 5-1 victory at home to Estonia.
Chile romp to win, USA seal Bosnian win, Colombia beat Serbia, Asamoah Gyan is Ghana hero
Holland can go a long way to securing a place at the World Cup finals in Brazil next summer with victory over Romania.
Holland recorded their fifth World Cup Group D qualifying win with a 3-0 victory over Estonia in Amsterdam.
Gabon caused upset as they held Portugal to a draw, while Didier Drogba scored as Ivory Coast triumphed in Austria.
Turkey got their World Cup qualifying campaign up and running with an emphatic 3-0 victory over 10-man Estonia in Istanbul.
Robin van Persie was on target for Holland while Romania and Hungary were also victorious.
Holland were stunned by Belgium, Argentina beat Germany and Russia drew in Fabio Capello's first match as manager.
Tarmo Kink is being linked with a move to Hungarian side Gyori ETO after being released by Middlesbrough.
Dublin is getting ready for a party atmosphere as Republic of Ireland look to seal Euro 2012 qualification on Tuesday night.


text:
Forgotten details?
or call 1800 284 789
Artwork by Gilimbaa Indigenous Creative Agency
The Standing Strong Together Award is presented by the RACGP National Faculty of Aboriginal and Torres Strait Islander Health to any Fellow or member of the RACGP and any Aboriginal and/or Torres Strait Islander person who have worked together to improve health outcomes for Aboriginal and Torres Strait Islander people. Nominations are open to all Fellows and members of the RACGP and to all Aboriginal and Torres Strait Islander people in Australia.
The Award winner will receive a commemorative trophy which will be presented at GP15 in September 2015. The RACGP will fund the cost of the winners' (two representatives) return economy class airfare and accommodation to attend the Academic Session, Fellowship and Awards Ceremony.
The 2014 Standing Strong Together Award winner was the Aboriginal Medical Service Western Sydney's Chronic Care Team. The team has been working together since 1991 to support Aboriginal patients with chronic diseases; overseeing Aboriginal health checks; conducting research, preventative health activities and group programs; delivering education programs; and providing cultural mentorship to staff at the Aboriginal Medical Service.
For further information about past winners, please visit our Honour Board.
Nominations for the 2015 Standing Strong Together Award open on 3 April 2015 and close on 5 June 2015.
The RACGP's National Faculty of Aboriginal and Torres Strait Islander Health provides one student bursary to enable an Aboriginal and/or Torres Strait Islander medical student currently studying at an Australian university to attend the RACGP annual conference GP15 on 21-23 September 2015 at the Melbourne Convention Centre.
Nominations for the 2015 Aboriginal and Torres Strait Islander Student Bursary Award open on 3 April 2015 and close on 5 June 2015.
Files on the website can be opened or downloaded and saved to your computer or device.
To open click on the link, your computer or device will try and open the file using compatible software.
To save the file right click or option-click the link and choose "Save As...". Follow the prompts to chose a location.
PDF Most of the documents on the RACGP website are in Portable Document Format (PDF). These files will have "PDF" in brackets along with the filesize of the download. To open a PDF file you will need compatible software such as Adobe Reader. If you do not have it you can download Adobe Reader free of charge.
DOC Some documents on this site are in Microsoft Word format. These will have "DOC" in brackets along with the filesize of the download. To view these documents you will need software that can read Microsoft Word format. If you don't have anything you can download the MS Word Viewer free of charge.
MP3 Most web browsers will play the MP3 audio within the browser
firstname.lastname@example.com Freecall 1800 000 251


text:
Want To Get Your Child To Go To Bed On Time At Night? Sick Of Having Power Struggles With Your Preteen? Want Your Children To Enjoy Doing Their Chores? Youll Find All These Answers And More In This Ebook. This Ebook Will Inspire You To Be A Great Parent.
Due to a heavy overflow, our team have yet to review this request. That said, we guarantee that the review will be made in due time by our thorough and unshakable staff in a professional manner. our site is highly respected amongst its peers in terms of speed and effectiveness, so feel free to check us out!
To visit this site, click here and enjoy the free tour...
All Rights Reserved. © Copyright Review Kings 2015.


text:
Read a transcript of President Barack Obama's address on Pakistan and Afghanistan from March 27, 2009, and discuss the new policy in The Takeaway's "user-annotated" document viewer.
In this speech, President Obama says the situation in Afghanistan has become "increasingly perilous" and warns that Afghanistan cannot be allowed to come under control of the Taliban or al-Qaida. He plans an influx of 4,000 troops plus a civilian corps in order to "disrupt, dismantle and defeat al-Qaida in Afghanistan and Pakistan."
Annotations [ ] Download MP3
More about President-elect Barack Obama and his appointees...


text:
Ohio Hotel Reservations
Visiting Northwest Ohio
Fall visitors to Northwest Ohio find it's not too late to get out and enjoy a wide range of outdoor activities, and communities from Wauseon to Fostoria to Sandusky promise plenty of ways to make the most of the remaining warm days.
With the warm sunshine will also go the locally grown produce and vegetables of the 2015 Sandusky Farmers' Market – so get it while the gettin's good. In addition to those fruits and veggies, the market invites Sandusky and Norwalk visitors to browse a variety of homemade goods, handcrafted gifts, and more, every Saturday through October 31st at the intersection of Hancock and Market Street in Sandusky's picturesque downtown area.
Families in Norwalk won't want to miss Rocktoberfest 2015 on October 24th. Taking over the downtown area, the event is fun for the whole family, with live music, a local marketplace, chili cook-off, art walk, kids' activities, plenty of food, and even a pet parade.
Port Clinton visitors leave the kids behind for the "Night of the Pub Crawl of the Living Dead" on October 31st. The 2015 Port Clinton Zombie Pub Crawl welcomes the undead to shuffle between participating pubs throughout historic downtown Port Clinton. Go all out – prizes will awarded to the top three costumes, as well as best couple, best group, and most creative.
Further west, south of Toledo, Bowling Green gets into the holiday spirit early, on November 20th and 21st. The 2015 Tree Lighting celebrates the season with two days of local merchant markets, kids' activities, horse-drawn wagon rides, and more – all culminating in the lighting of the tree.
If that's not enough, the 2015 Community Holiday Parade also makes its way through downtown Bowling Green at 10 a.m. on November 21st, bringing with it festive floats, live music, holiday treats, and more.
Of course, there's no holiday celebration quite like the 2015 Santa Hustle. On December 20th, the festive 5K sends Santa Claus costume-clad runners along a course beginning in Castaway Bay and continuing through Cedar Point, outside of Sandusky. Don your own red stockings or cheer the Santas on from the sidelines – the finish line celebration will have treats for all and a cash bar will help runners rehydrate with their favorite beer.
Toledo & Northwest Ohio Hotel Map
Travel Region Favorites
- 32 Things To Do With Kids in OH!
Fun in Ohio
Here are 32 family-friendly museums, rides, parks, stores, and more to do throughout the Cleveland, Toledo, Columbus, and Cincinnati areas.
- Outdoor Ohio
Explore outdoor Ohio and the many outdoor attractions within. From skiing in the winter, to the hiking and golf in summer.
7 Best Western Hotels
in Toledo & Northwest Ohio
Falcon Plaza
Bowling Green
Fostoria Inn & Suites
Napoleon Inn & Suites
Port Clinton
Port Clinton
Sandusky Hotel & Suites
Del Mar
Toledo & Northwest Ohio Events
June 2015
2015 Sandusky Farmers' Market
Peruse locally grown produce and vegetables, homemade goods, handcrafted gifts, and so much more at the Sandusky Famer's Market, held every Saturday in downtown Sandusky all summer long. The market opens at 8 a.m.
October 2015
2015 Port Clinton Zombie Pub Crawl
Night of the pub crawl of the living dead – or so it seems. Enjoy downtown Port Clinton with other members of the walking dead. The event begins at 7 p.m.
2015 Rocktoberfest
A fun-filled event held in downtown Norwalk, featuring live music, a local marketplace, chili cook-off, art walk, kids' activities, plenty of food, and even a pet parade. Event start time is TBA.
November 2015
2015 Tree Lighting
Celebrate the upcoming holiday season with Bowling Green residents with two days of local merchant markets, kids' activities, horse-drawn wagon rides, and the tree lighting ceremony. The fun begins at 6 a.m. Friday and 9 a.m. Saturday in downtown Bowling Green.
2015 Family Fun Day
Head over to the Sandusky Mall for an afternoon of puppet shows, costumed characters, free kids' activities, and much more – an ideal even for the young ones. Festivities begin at 10 a.m.
2015 Community Holiday Parade
An annual event held in downtown Bowling Green featuring festive floats, live music music, beverages and treats, and much more. The event begins at 10 a.m.
December 2015
2015 Santa Hustle
A festive 5K beginning in Castaway Bay, running through Cedar Point in Sandusky. Participants will be in Santa costumes. Treats and a cash bar will be offered for all runners. The fun begins at 9 a.m.