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Day 8: 9:00 A.M. - 10:00 A.M.
Episode Reviews (9)
Amazing Episode!.
Wow!. What an amazing episode!. This new plot of the season eight hooked me so much from last installment and it´s explosive ending.
But i didn´t expected this perfect follow up.
A really perfect episode!.
Engaging, brutal, breathtaking and surprising.
Kiefer Sutherland gives us his best performance in the season yet. A really angry Bauer, who does really shocking things in this episode, and Gregory Itzin, who returned to the series as Charles Logan in the last episode, shows that his Logan is back with his own personality and not like in the awful season six.
Jack seeks his solace searching all the people who were involved in Renee´s tragic death and he discovers a really important twist.
This episode is not only fully entertaining and tense as 24 used to be.
This one is an excellent and too much better follow up from the last one.
It could be stay at the same level of supremacy than the episode 16 itself.
It confirms that 24 ultimate ending is gonna be shocking, never seen before and really surprising.moreless
Jack loses his mind
After the previous episode, a number of fans and critics alike were floored to discover that Renee Walker's death was a pre-planned plot point. Apparently Howard Gordon defended this plot twist as a great move, and praised the notion of sending Jack into a tailspin at the end of the season/series. And apparently Keifer Sutherland was on board with the idea, which just goes to show that some producers should stay the hell out of the writers' room.
Frankly, this is exactly the kind of thinking that has plagued "24" for years. It has also been a hallmark of Howard Gordon's writing style. To be fair, this is not something that falls on Gordon's shoulders alone; there is an entire writing staff that shares the blame for carrying forward a vision for the eighth season that undermines Jack's heroic journey and therefore the entire point of the series. But longtime readers, going back to the "X-Files" days, know that Gordon's plot and character choices have always been a subject of criticism.
Despite the grievous error of the previous episode, this installment manages to bring matters into focus. Jack's personal response to Renee's death gets some well-deserved attention, but there is also a welcome depth to President Taylor's plot thread.
Jack manages to keep himself reined in for the most part, but something has definitely come undone behind those eyes. The difference is simply his self-control. Earlier in the series, Jack would have gone on a massive rampage from the beginning. While Jack doesn't quite hold back with Dana Walsh, he does manage to keep his wits about him.
Yet during his confrontation with Bazhaev, there's no doubt that Jack is primed and ready for violence. And his moral compass is spinning completely out of control. There's no doubt that he would kill anybody who got in the way of putting those responsible for the atrocities of the day where they belong.
And that's what makes President Taylor's decision to let the Russians get away with Hassan's assassination, the terrorist threat against New York, and so many other things such a punch to Jack's gut. He is completely floored by the notion that President Taylor is choosing political expediency over such a clear-cut moral imperative. This isn't a debate over counter-terrorist tactics; this is real politik at its ugliest.
Of course, it all comes back to the symbol of all things ridiculous on "24". No, not Kim Bauer; she was just poorly written and stuck in inane plot threads. Charles Logan, on the other hand, was the terrorist President of the United States. The concept itself boggles the mind. As does the notion of ever trusting someone like Logan when he comes calling with a solution to a problem that didn't exist just a few hours earlier.
That's the one thing that hobbles this episode. It's pretty damn clear that Logan knew about the Russian collusion with the IRK dissidents because he was knee-deep in everything that happened. He's all but caught red-handed halfway through the episode, and yet, President Taylor just lets the matter go in favor of listening to the former Terrorist-in-Chief's advice.
While the advice does have a certain "ends justify the means" logic to it, it is predicated on two erroneous assumptions. First, that Charles Logan would ever give someone such strident advice on something that wasn't of deep and abiding value to his own self-interest. And second, that any peace accord for the Middle East, particularly one forged with a progressive Islamic regime, would truly end the conflicts in the region.
The problem is that Taylor is falling into the same trap that so many other politicians and leaders encounter: the Legacy Hunt. It's not enough to be a strong and competent leader. There has to be something monumental that history will always remember in their section of the textbook. When presidents go tilting at the legacy windmills, they almost always leave ethics and morality behind.
In a sense, this fits the overall theme of the season, which is not a bad thing. Taylor is failing to learn from the mistakes of the past, and she will find herself on the wrong end of Jack Bauer's resolve as a result. Of course, this is also quite unfortunate, because the series should have ended on a better note. President Taylor had grown to be the first president since David Palmer to trust Jack's judgment. Jack's restoration, and that of CTU, was bringing the series full circle. It's hard to imagine that happening now.
Overall, this episode managed to make the best of a bad situation, even if some of the logic was twisted to make certain characters make uncharacteristic choices. It was good to see a lot more of President Taylor; the writers haven't given her nearly enough to do. Though it's hard to see how the writers are going to end this season/series well, this isn't a bad start.moreless
Jack begins his search for Renee's killer. He learns that it was the Russian government, not the IRK, who is behind all the attempts to stop the peace process. Disgraced former president Charles Logan learns what Jack is doing and tries to stop him.
Last season, President Taylor made the decision to allow her daughter to be prosecuted for murder rather than cover it up. A tough decision, but it was the right one. I was somewhat surprised, and even disappointed, that in the face of another tough decison, she decided to go with Logan and cover up the truth. It for all intents and purposes, flies on the face of everything Taylor stands for. It's an unfortunate letdown from the person she was thought to be. In the end I shouldn't be surprised. After all it is "24" we are talking about, right?moreless
Insane Jack and a welcomed Logan make for great 24!
Logan and Jack (as always) stole the show in this episode. You can see the evil Jack is capable of directly in his eyes and absolutely nothing will have a chance of stopping him from reaching "justice." Not even the President!
Gregory Itzin's acting is superb. He fires in the role of Logan and really shines when he is on the screen. I can't wait for a confrontation between Logan and Bauer!
Overall, the season seems to be heading in the right direction towards a phenomenal climax. President Taylor is also really getting a taste of her Presidency role and she seems to be following in the footsteps of Logan: covering the truth for the good of the country!moreless
lets try this again......
my review I just typed didn't show ....so here goes again....At least we have Jack being the old Jack! And having Logan back is good too. He plays such an excellent "bad" guy. Now for the WORSE part.....Once again we see the Presidents sickening ego in play. She IGNORES Jacks' warnings about the the Russians being involved. Which Palmer would NEVER have done! This President, is like the one we have today.....not interested in the "GREATER GOOD" just interested in her or his career and WORLD leadership. She's not in a tough position becaues she knows she's simply going to do what she can to further HER career, whether it's walking over dead American bodies etc. This peace conference won't mean a thing on 24 or in real life. Sorry, I got side tracked with real politics. In any event it makes me sick the way 24 has has gone.
I can't see anything really happening in the few remaining episodes. So disappointed in Sutherland for allowing the show to go down this pathetic road. But that's liberal Hollywood for you....sigh...it should have simply ended when TWO seasons ago. I'll keep watching and hoping JUSTICE will finally pervail!!!moreless
Political games
I most say, the way this episode ended.. it did not surprised me.. It was all going that point. Jack was quite out of control before.. on the hospital crying. We have seen him doing that only very few times. And then.. when people he had maybe most faith in.. turns him down and plays her political game.. it just... I think he felt betrayed by his own side again and turns around against everyone.. and this time there is no Chloe to support him either.
So.. majority it was Jack episode.. leading to that point.. seeing how everyone stand aside him..
But Logan.. oh.. never liked him and he is back..and all his intrigues too.moreless
We see the sad aftermath of Renee Walker's death and the backstabbing arena called politics in this episode.
Jack was amazing in this episode. The acting was truly superb. The range of emotions, the ferocity, the calm, icy cool with which he executed everything he did....
Of course, last week's episode was by far the saddest episode I saw all season, but the beginning of this episode is in a close third. How very horrible for Jack to realize that he can't tell the nurse anything she's asking - not about Renee's family, not anything. It really highlights how little time he and Renee had together in the most heartbreaking way possible.
Jack got a ten from me, but Chloe really disappointed me. I know she only "did what she had to do," but really....the protagonists of this show have been known for working around the system, for doing the right thing for each other even under the most difficult of circumstances. Where's that spine Chloe showed when she pulled a gun on that jerk earlier this season? It surprised and disappointed me that the minute she got a pat on the back from the White House, she completely abandoned Jack. Maybe she wouldn't have been able to do much, but she could've tried.
I seriously sympathize with President Taylor. What a hard position to be put in. I hope she's ready to deal with the consequences of what she did, though. She had to've known the minute Jack said, "I understand," and walked from that room, that she had completely betrayed him. I'm not saying her decision was wrong or right, because there is no right or wrong situation here, but I can't see Jack helping her after this. An episode without Renee Walker was sad and sucked, but the episode was still pretty good. I enjoyed it, anyway, and I'm kind of looking forward to Jack on the warpath. I'm concerned with how this will all be wrapped up for poor Jack, being the last season and all, but we do have six hours left. I'm crossing my fingers; here's to hoping for an even better episode next week.moreless
Good to see the old Jack back for one last show.....
I mean let's face it Jack was never going to be back to his old ruthless self if Rene hadn't died. This episode was one of my best because for one i saw the old jack back. Secondly Charles Logan is pulling off one of his oldies . I mean the guy is just so good in this role you gotta say his the increment the show was lacking at this point.It's good to see Chloe is for once not supporting Jack and this makes things harder for jack as he pursues what should be the ultimate bad guys in the game.... It's gonna be one hell of a 6 hours left in the day i can't waitmoreless
Wow, what an episode. Its bittersweet how, so soon after cancellation, this season of 24 has turned around. I really didn't like the first half, everything felt like a giant slow 24 cliché, but it's almost like somebody behind the scenes has put their foot down and moved everything forward quickly.
When Logan decided to talk to the President and again when the President wanted to meet Jack at CTU, I immediately thought "great, I bet all of this travelling back and forth means it'll take at least two episodes for the President to find out about Russia". How wrong was I!
Jack has always been about the greater good, and its cost him dearly. He sacrifices everything, only for the people who ask him to do so, to then turn on him or conveniently forget the huge part he played in it.
I really hope the end of this season has Jack letting go of the greater good, and doing what *he* needs to do, not what his country needs him to do.
Also I think somebody needs to remind President Taylor about the fate of the three previous presidents and the one thing their demise have in common...They all turned their back on Jack.moreless


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A 55 card addition to the El Grande: König & Intrigant expansion. Some, but not all, of these cards were published in the American version of Rio Grande Games The El Grande Expansions. Cards unique to this expansion are: Moving Day, Pushing, Civil War, Alliance, Revolution, Danger of Collapse, Whirlwind, and The Queen cards.
Gives players an additional 11 card choices when building their respective K&E play decks.
A subset of these cards are included in both the 10th Anniversary edition of El Grande, as well as The El Grande Expansions

subset: commoncrawl


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Cardiovascular implications from untreated human immunodeficiency virus infection
Atherosclerotic cardiovascular disease (CVD) has become an important cause of morbidity and mortality among individuals with human immunodeficiency virus (HIV) infection with access to antiretroviral medications, as the risk for AIDS has fallen and life expectancy improved. Traditional CVD risk factors are often more common among individuals with HIV infection, and traditional prevention strategies remain important. Recent data have revealed that untreated HIV infection itself amplifies additional pro-atherogenic mechanisms related to immune activation, inflammation, coagulation, and lipoprotein particle changes (e.g. high-density lipoprotein particles). Some of these mechanisms are attenuated, though incompletely, with antiretroviral therapy (ART)-related suppression of HIV replication. Exposure to ART is also associated with variable toxicity that may simultaneously decrease (via viral suppression) and increase CVD risk. Ultimately, additional adjunctive treatment will be needed to mitigate premature CVD risk among contemporary HIV-infected patients with access to ART.
- Untreated HIV infection
- Cardiovascular disease
- Antiretroviral therapy
For human immunodeficiency virus (HIV)-infected persons with access to effective combination antiretroviral therapy (ART), premature atherosclerotic cardiovascular disease (CVD) is now a leading cause of morbidity and mortality.1 Advancing age, resulting from prolonged life expectancy, and a higher prevalence of traditional risk factors (e.g. smoking) remain important contributors to CVD risk in this context.2,3 However, HIV-specific factors are also pro-atherogenic, both as a consequence of antiretroviral toxicity and HIV infection itself.
Findings from the Strategic Management of AntiRetroviral Therapy (SMART) study, and follow-up biomarker analyses, have fundamentally changed our understanding of HIV-associated CVD pathogenesis and focused attention on the consequences of untreated HIV infection. In SMART, the relative risk for CVD events was 60% greater for a strategy of episodic ART use, when compared with continuous ART use.4 Recent data have further demonstrated that untreated HIV infection amplifies a number of factors that are known to be pro-atherogenic (Figure 1). The purpose of this review is to explore potential mechanisms by which HIV infection, independent of antiretroviral treatment, may increase CVD risk, and in the process identify factors that may be targeted by HIV-specific CVD prevention strategies.
Immune activation and inflammation
Immune dysfunction, activation of lymphocytes, and inflammation are hallmarks of untreated HIV infection that may have broad consequences beyond AIDS-related disease progression.5,6 Important associations between inflammation and CVD pathogenesis are also well established. Elevated C-reactive protein levels, an acute phase reactant, and interleukin (IL)-6 levels, a cytokine released by monocytes and lympocytes that stimulates C-reactive protein release from hepatocytes, are both independent predictors of CVD events in the general population.7,8 C-reactive protein and IL-6 levels are elevated in HIV-infected patients and predict risk for CVD and all-cause mortality.5,9,10 Specifically in SMART, baseline levels of these biomarkers were associated with excess CVD risk during the study.5 Among participants in SMART with HIV suppression at baseline, the increase in IL-6 levels 1 month after stopping ART strongly correlated with the extent of the rise in HIV RNA level during this time (P= 0.0003).5 The mechanisms underlying chronic inflammation and release of cytokines with HIV infection are complex, but may, in part, be a result of HIV replication (even at low levels in the context of ART), activation, and dysregulation of leucocytes (and antigen-presenting cells) and/or damage to the gastrointestinal lymphatic system and mucosal barrier with increased bacterial translocation.11
Despite effective treatment with ART, chronic immune activation persists during HIV infection. Among SMART participants with undetectable HIV RNA levels, high-sensitivity C-reactive protein and IL-6 levels were elevated by 38 and 60%, respectively, when compared with controls from the general population cohort Multi-Ethnic Study of Atherosclerosis (MESA).10 Furthermore, HIV 'elite controllers' (individuals capable of maintaining undetectable HIV RNA levels in the absence of ART), as well as those with ART-associated HIV suppression, both exhibit greater activation of CD8+ and CD4+ T-cells when compared with uninfected persons.12 Among patients in the Women's Interagency HIV Study, greater T-cell activation (of either CD8+ or CD4+ cells) was associated with subclinical arterial disease defined either by the ultrasound presence of carotid lesions or impaired carotid artery distensibility.13 The contribution of co-pathogens may also contribute to accelerated atherosclerosis in HIV patients. Hsue et al.14 described greater T-cell activation, high-sensitivity C-reactive protein levels, and carotid artery intima–media thickness (CIMT) among HIV-infected vs. uninfected persons, and cytomegalovirus-specific T-cell responses were independently associated with CIMT. Cumulatively, these data suggest that suppression of HIV replication below the level of detection by clinical assays will not fully attenuate chronic activation of the host's immune system, and anti-inflammatory treatments should be studied as part of comprehensive CVD prevention in this population.
Alterations in lipids and lipoproteins
Human immunodeficiency virus infection has a profound impact on blood lipids.15–17 Early in the epidemic, Grunfeld et al.15 described elevated triglyceride (TG) levels in patients with AIDS resulting from decreased clearance of TG, in part, through cytokine-mediated decrease in lipase activity. Among HIV-infected patients in the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study, the relative risk of myocardial infarction for each doubling of TG level was 1.67, and fell to 1.11 after adjustment for traditional risk factors and other lipid levels.18 Pro-atherogenic changes in low-density lipoprotein cholesterol (LDL-C), including increases in small dense LDL, are also described among HIV-infected individuals, but in large part have been attributed to ART exposure vs. HIV infection per se.17,19
The primary lipoprotein alteration related to untreated HIV infection is a decline in high-density lipoprotein cholesterol (HDL-C). Among patients in the Men AIDS Cohort Study (MACS), HDL-C declined following HIV seroconversion.17 After initiation of ART in MACS, HDL-C remained ∼10 mg/dL below pre-infection levels while total cholesterol (TC) exceeded pre-infection levels.17 In SMART, both TC and LDL-C declined after stopping ART, but the HDL-C decline was such that the TC/HDL-C ratio actually increased.20 Thus, whether in the treated or untreated state, HIV infection adversely affects the total to HDL cholesterol ratio—one of the best lipoprotein indices in terms of predicting CVD event risk.21 This is also consistent with HDL-C declines described in other states of chronic inflammation, including systemic lupus erythematosus.22
The atheroprotective mechanisms of HDL include reverse cholesterol transport (RCT) as well as pleiotropic effects related to antioxidant and anti-thrombotic properties.23 The acute phase response in general has been associated with changes in HDL structure and function including lower levels of HDL-C and the HDL-associated apolipoprotein A1, impaired cholesterol efflux from macrophages, and a reduced ability to inhibit oxidation of LDL.24 Furthermore, the HIV-nef protein has been shown to block ATP-binding cassette transporter A1-dependent cholesterol efflux, resulting in the accumulation of lipids in macrophages.25 In the later stages of RCT, HIV infection up-regulates cholesteryl ester transfer protein, which facilitates the delivery of cholesterol esters by HDL-C to atherogenic lipoprotein particles.26 Thus, both chronic inflammation and HIV infection are associated with pro-atherogenic changes to the function and structure of HDL particles.
Methods that characterize HDL particle size and number, such as nuclear magnetic resonance spectroscopy, allow further assessment of HDL structure that informs clinical risk beyond traditional chemical measures of cholesterol (e.g. HDL-C).27 In SMART, the total HDL particle number at baseline, and the concentration of large and small HDL particles in particular, were inversely associated with CVD risk.28 Among SMART participants with previously suppressed HIV RNA levels, the drop in total HDL particle concentration after stopping ART was inversely associated with rise in HIV RNA levels.28 In a smaller study of patients with untreated HIV infection, small HDL particle concentration was inversely associated with IL-6 levels.29 The risk for CVD in SMART when considering both baseline IL-6 levels and HDL particle concentration is presented in Figure 2. After adjusting for levels of either high-sensitivity C-reactive protein or IL-6 in SMART, the HDL particle associations with CVD were attenuated but still present.28 Finally, among HIV-infected persons in MACS receiving ART, the concentration of total HDL particles remained less than for uninfected persons.19 Hence, HIV-associated low HDL is in part the result of HIV-related inflammation and appears to contribute to excess CVD risk in this context.
Recent data suggest that HIV infection may result in a pro-coagulant state that has broad consequences for premature end-organ disease, both CVD and non-CVD related.5 d-dimer, fibrinogen, and other markers of coagulation (e.g. factor VIII and von Willebrand factor) are predictors of CVD and mortality risk in the general population.30–33 The risk for incident CVD or all-cause mortality for highest vs. lowest d-dimer levels at baseline are reported for HIV-infected participants in SMART and for the general population cohort MESA in Table 1. Both SMART and MESA used the same core laboratory for d-dimer measures, and in SMART, 90% of deaths were non-AIDS related with 28% attributable to CVD.4,5,31 Higher d-dimer levels were independently associated with risk for CVD in SMART but not MESA (and the association in SMART became stronger when adjusted for additional traditional and HIV-specific risk factors; Table 1).31,34 Pro-coagulant activity may, in part, be driven by HIV replication and immune activation, though specific changes in prothrombotic and anti-thrombotic pathways in untreated and treated HIV infection, compared with uninfected persons, has not been well described.
|MESA (general population)
|SMART (HIV infected)
|Study sample
|Enrolment characteristics
|Free of clinical CVD at enrolment
|Median CD4 601 cells/mm3; 82% on ART
|Number of participants
|898 (nested case–control)
|Age in years, [mean (range)]
|62 (45–84)
|50 (23–76)
|d-dimer level, [median (µg/mL)]
|Risk by 4th/1st quartile of baseline d-dimer level (95% CI)
|2.3 (1.66–3.18)
|2.2 (1.4–3.6)
|1.3 (0.90–1.85)
|2.4 (1.4–3.9)
|All-cause mortality
|Risk by 4th/1st quartile of baseline d-dimer level (95% CI)
|5.8 (3.6–9.3)
|12.4 (4.2–37.0)
|2.8 (1.7–4.6)
|11.6 (3.8–35.7)
SMART and MESA d-dimer findings have been previously reported.5,31,34 In SMART, after adjustment for age, race, ART use, HIV RNA level, CD4 count, treatment group, co-infection with hepatitis B or C, smoking status, body mass index, prior CVD, diabetes, total-to-high-density lipoprotein cholesterol ratio, and use of blood pressure or lipid-lowering therapy, odds ratios (95% CI) were similar for CVD (2.5; 1.4–4.3) but were more extreme for all-cause mortality (41.2; 7.5–225.6).5,34 In SMART, risk for death was reported up to the study protocol change in January 2006, but risk for CVD included additional follow-up until July 2007.5,34
CVD, non-fatal and fatal cardiovascular disease as reported for each cohort; MESA, Multi-Ethnic Study of Atherosclerosis; SMART, Strategic Management of AntiRetroviral Therapy.
aAdjusted for age, sex, and race/ethnicity.
Higher d-dimer levels were more strongly associated with risk for all-cause mortality (than for CVD), and these associations were more extreme for HIV-infected (SMART) compared with uninfected (MESA) individuals (Table 1). d-dimer has also been associated with non-atherosclerotic outcomes in the general population. Clinically, risk for venous thrombo-embolic disease has been evaluated using d-dimer levels for some time.35 In MESA, d-dimer levels predicted cancer mortality as well as CVD.31 Coagulation and fibrinolysis are key features of sepsis, and d-dimer levels are associated both with the severity of sepsis on presentation and the risk for subsequent mortality.36 Similarly, among patients presenting with community-acquired pneumonia, d-dimer predicted disease severity and subsequent mortality.37 Finally, higher d-dimer levels are associated with functional decline, as well as mortality, in elderly patients.38 The pronounced d-dimer odds ratios for all-cause mortality among participants in SMART (Table 1) are consistent with these data, and further suggest that HIV-related activation of coagulation pathways has important consequences for a broad range of end-organ diseases, beyond CVD. Higher baseline fibrinogen levels among HIV-infected participants in Study of Fat Redistribution and Metabolic Change in HIV Infection (FRAM) were associated with increased mortality risk, independent of traditional risk factors, C-reactive protein level, or CD4 count, though whether this differs from fibrinogen risk prediction among uninfected populations is not clear.32,33,39 Whereas thrombotic activity is intuitively connected to vascular disease and the development of CVD, questions remain regarding the specific mechanisms by which HIV-related coagulation adversely affects other quite divergent pathologies.
Additional epidemiological data suggest that the pro-coagulant state associated with HIV infection increases the disease risk beyond triggering events in the short term, and this risk is not fully attenuated by ART use. Baseline d-dimer levels in SMART predicted mortality risk equally over the near (<2 years) and longer (>2 years) term, and were not attenuated by adjustment for the HIV RNA level, CD4 count, or traditional CVD risk factors.5,40 In another HIV case–control study, d-dimer levels, but not high-sensitivity C-reactive protein, predicted incident CVD events occurring either within 4 months or after 2 years.41 Finally, although changes in d-dimer levels are correlated with changes in HIV RNA levels after stopping or starting ART, d-dimer remained 49% elevated for patients in SMART with undetectable HIV viral loads when compared with general population controls from MESA.5,10,42–44 Similar to the case with inflammation, adjunct treatments will be needed in combination with ART to attenuate pro-coagulant activity.
Recent pathogenesis studies suggest that HIV infection may modulate coagulation activity via tissue factor (TF) pathways as well as platelets. In a retrospective case–control study, soluble TF levels measured ∼4 months prior to the CVD event were elevated when compared with HIV-infected patients who did not have a subsequent CVD event.41 In another cross-sectional comparison, monocyte expression of TF correlated directly with HIV RNA levels and was increased between HIV-infected vs. uninfected persons.45 In this same study, TF expression on monocytes also correlated with d-dimer levels and with soluble CD14, a marker of monocyte responsiveness to lipopolysaccharide exposure.45 Lipopolysaccharide levels are an indicator of plasma exposure to bacteria, and prior sentinel HIV pathogenesis studies suggest that increased microbial translocation across intestinal mucosal surfaces—a consequence of permanent damage to gastrointestinal associated lymphatic tissue—directly contributes to chronic immune activation among individuals with HIV infection.11,46 Cumulatively, these data support the hypothesis that HIV replication and immune activation drives coagulation and fibrinolysis, in part, via up-regulation of TF pathways.
Platelets provide an additional link between HIV-mediated inflammation and coagulation, as they are activated at sites of infection or injury and interact with monocytes, lymphocytes, and endothelial cells.47–49 Among patients with untreated HIV infection, thrombocytopenia is a classic haematologic abnormality that worsens with advancing HIV disease.50 In a small study of 27 patients with thrombocytopenia initiating ART, declines in plasma HIV RNA were associated with a rise in platelet counts, and over half of the participants attained platelet counts in the normal range.50 Human immunodeficiency virus-1 also binds, and is highly associated, with platelets in the blood, which has been postulated to facilitate clearance and/or dissemination of the virus.51,52
Beyond their role in acute atherothrombotic events (e.g. myocardial infarction), chronic platelet activation may promote atherogenesis through interactions with endothelial surfaces.47 Ex vivo studies have demonstrated greater platelet activation, chemokine release (e.g. regulated upon activation, normal T-cell expressed, and secreted), and reactivity to epinephrine, among HIV-infected vs. uninfected participants.53,54 Among participants with undetectable HIV RNA levels on ART and normal plasma platelet counts, levels of platelet microparticles (cell-membrane fragments released upon activation) were still over 80% elevated when compared with uninfected controls.55 Data on platelet toxicity related to ART are limited, though abacavir exposure has been shown to cause platelet hyper-reactivity in vitro.56 These studies support the need for additional research on the benefits of anti-platelet medications among HIV patients, given that they are generally safe, widely used as part of secondary CVD prevention strategies, and may be uniquely beneficial in the context of HIV infection.
Vascular injury and atherosclerosis progression
Human immunodeficiency virus replication may activate endothelial surfaces both directly and/or via up-regulation of pro-inflammatory cytokines.57 Biomarkers of endothelial activation are elevated in HIV-infected compared with uninfected controls.29 In the context of stopping ART, soluble vascular cell adhesion molecule (sVCAM-1) levels increase and correlate with the increase in HIV viral replication.43,58 Levels of sVCAM-1 and von Willebrand factor specifically have been shown to decline after ART initiation consistent with a decrease in activation of endothelial surfaces.42,59 In cross-sectional studies, untreated HIV infection or detectable HIV RNA levels have been associated with impaired measures of vascular function.60,61 In a study of 82 patients starting ART, endothelial dysfunction [assessed via brachial flow-mediated dilation (FMD)] improved after 6 months and was associated with the decline in HIV RNA levels.62 However, among HIV-infected patients receiving ART for an average of >5 years, impaired FMD was associated with exposure to protease inhibitors (PIs) and alterations in lipoproteins and glucose.63 The complexity of these competing risks between HIV replication and antiretroviral toxicity is highlighted by another study reporting worsened femoral artery stiffness, but improved endothelial dysfunction plasma markers, after starting ART.64
Atherosclerotic burden estimated by ultrasound measures of CIMT also highlight contributions of ART exposure and ART itself. Carotid artery intima–media thickness has been associated with vascular inflammation (e.g. sVCAM-1 levels) and duration of ART exposure among HIV-infected patients.65,66 In the FRAM Study, the largest comparison of HIV-infected and uninfected populations to date, HIV infection was independently associated with greater CIMT to a degree similar to having diabetes or being a smoker.67 In FRAM, the duration of tenofovir use was also associated with lower CIMT.68 Ultimately, HIV-infected individuals with undetectable viral loads, whether elite controllers or taking ART, still have greater CIMT when compared with uninfected controls in cross-sectional studies.69
Longitudinal studies of atherosclerotic progression among HIV-infected persons are largely consistent with these findings. In the Study to Understand the Natural History of HIV and AIDS in the Era of Effective Therapy (SUN), maintaining HIV suppression (vs. a detectable HIV RNA level) was independently associated with less CIMT progression over 2 years.70 A single-site study also reported greater CIMT progression among HIV-infected vs. uninfected persons, and the magnitude of progression was associated with C-reactive protein levels after adjusting for traditional and HIV-specific factors.71 In this study, CIMT progression was most pronounced at the bifurcation of the internal and external carotid artery, both in the presence or absence of ART, but the clinical relevance of hypothesized differences in HIV-related atherosclerotic progression at different regions of the carotid artery is unclear.71 An important limitation of all these longitudinal CIMT studies remains the inability to disentangle the CVD consequences related to ART exposure and untreated HIV infection per se.
Data that HIV elite controllers also exhibited greater CIMT progression, when compared with uninfected controls, suggest that achieving a fully suppressed HIV RNA level will not fully mitigate accelerated atherosclerosis in this population.71 It also appears that progression of atherosclerosis may differ by the specific antiretroviral components of a patient's ART regimen. In the SUN study, progression of CIMT was less for persons taking non-nucleoside reverse transcriptase inhibitor (NNRTI)- vs. PI-based ART regimens, independent of maintaining HIV suppression.70 In a separate study, the development and progression of carotid lesions was reportedly greater among patients treated with PIs when compared with those receiving NNRTIs.72
Antiretroviral therapy to reduce cardiovascular disease events among individuals with human immunodeficiency virus infection
Epidemiological studies have reported greater risk for myocardial infarctions and other CVD events among HIV-infected compared with uninfected individuals.73,74 SMART was the first clinical trial to demonstrate that untreated HIV infection increases the risk for CVD events, but the 60% increased risk associated with intermittent ART use was primarily due to stopping ART among participants who were already on treatment at enrolment and was of marginal statistical significance (P= 0.05).4 Subsequently, when the trial was stopped early and all participants were placed on ART, the CVD risk associated with intermittent ART use was reduced.75 These data, and additional observational cohort data, have motivated claims that HIV infection should be treated earlier (i.e. at higher CD4 counts) to reduce the CVD risk.76,77 However, there are currently no randomized data comparing the CVD risk between ART treatment and the state of untreated HIV infection to account for any relevant selection bias and unmeasured confounding.
The pro-atherogenic mechanisms of antiretroviral drugs, and PIs in particular, have classically been associated with lipodystrophy leading to metabolic disorders including insulin resistance and dyslipidaemia.78 Additional data have also highlighted CVD toxicity related to inflammation, immune activation, oxidative stress, vascular injury, mononuclear cell adhesion, and hyperhomocysteinaemia, with different PIs having different toxicity in this regard.63,78–82 The relationship between exposure to ART and risk for clinical CVD events has been previously reviewed.83 In the D:A:D Study, ART-associated risk for myocardial infarction was attributed to cumulative exposure to PIs but not NNRTIs.84 Some, but not all, of this risk is accounted for by the classic pro-atherogenic lipid changes associated with PI exposure.84 With additional follow-up in D:A:D, including over 1 78 000 person-years, cumulative exposure to the NRTI abacavir, and the PIs indinavir and lopinavir-ritonavir has been specifically associated with increased risk for myocardial infarction.85 Minimizing the variable CVD, and non-CVD, toxicity related to individual antiretroviral drugs has become one of the greatest clinical challenges when managing contemporary HIV-infected patients who have achieved suppression of HIV replication.
Untreated HIV infection amplifies several pro-atherogenic mechanisms, and appears to accelerate atherosclerotic progression and the development of clinically overt CVD. While stopping ART among patients with HIV suppression is associated with inflammation (e.g. IL-6 increases), pro-coagulant changes, and declines in HDL that increase CVD risk, the compensatory improvement in these pathways after starting ART appears to be incomplete. Furthermore, exposure to specific antiretrovirals has been clearly shown to be associated with variable CVD-related toxicity. Thus, when the risk of AIDS is low and non-AIDS morbidity (such as CVD) dominates, the net benefit of starting ART, compared with untreated HIV infection, is unknown (Figure 3). The ongoing START (Strategic Timing of AntiRetroviral Therapy) trial is a randomized comparison of early vs. delayed treatment of HIV infection, and will provide much needed randomized data to address this pressing clinical question.
Treatments commonly used for CVD prevention in the general population may have increased utility for patients with HIV infection. In particular, vaso-protective agents and those with anti-inflammatory and anti-platelet activity [e.g. angiotensin-converting enzyme-inhibitors/angiotensin receptor blockers, 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors ('statins'), and aspirin] may be uniquely beneficial for HIV-infected patients taking ART with undetectable HIV RNA, but who remain at an increased risk for CVD due to chronic inflammation and thrombogenesis. Indeed, trials from the general population suggest that statins are effective for CVD prevention among persons with elevated C-reactive protein and normal/low LDL levels, while aspirin may be more beneficial for CVD prevention among those with higher vs. lower C-reactive protein levels.86,87 Trials studying the unique effects of statins among HIV-infected patients are ongoing, though to date, data are lacking on anti-thrombotic strategies in this population.
In the coming decades, accelerated HIV-related CVD risk is likely to become even more prevalent. In the USA, over half of all HIV-infected individuals may be over the age of 50 years by 2015.3 In this context, prevention strategies that target traditional modifiable CVD risk factors (e.g. smoking cessation) should continue to be strongly emphasized in clinical practice. Ultimately, HIV-specific prevention strategies involving adjuvant treatment given in addition to ART that target key inflammatory and coagulation pathways should be developed and studied to mitigate premature HIV-associated CVD.
Daniel Duprez and Jacqueline Neuhaus are thanked for advice, consultation, and assistance with inclusion of data from SMART.
Conflict of interest: J.V.B. reported research support from US National Institutes of Health, US Center for Disease Control and Prevention, American Heart Association, Gilead, and ViiV. J.D.L. reported research grants from US National Institutes of Health, the European Commission, and a consortium of pharmaceutical companies (Boehringer-Ingelheim, Roche, Abbott, Bristol-Myers Squibb, Merck, Sharp & Dohme, GlaxoSmithKline, Tibotec, Pfizer, and Gilead), which together with the European Medicines Agency (EMA) and academic and patient communities, provided support for the D:A:D Study.
- Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2011. For permissions please email: email@example.com


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Nice neighborhood, a bit far from city center (but near to some historical sights). The only problem is that dogs here bark all night! Free use of kitchen and nice common space. Really hard beds. Cheap!
It was easy to book online and the place is a short ride from the airport. Nothing in Puerto is too far from the airport anyway. Tricycle will cost you around 60 pesos to get to Mendoza Street. Emanuel, the owner and his family are really really nice and helpful. If you want to do the Underground Tour - he...
Due to a delay in the ferry schedule we arrived at 2am in the morning. From the ferry I made a phone call to check if it was alright to arrive late. Luckily for us they welcomed us at 2.30am with a smile. This is a good example of the friendliness of the owner and staff. They helped us in...
this guesthouse is pretty beautiful inside, the common room is nice. the room we were was ok but the mattress was too thin. we never really saw the people who work there but they looked nice. we asked for a mosquito net and we had to "build" it by ourselves, not so easy, the girl who gave it to us...
Stayed here for a couple nights in Puerto Princesa, Manny's wife was really kind and helpful and Manny himself was great to arrange accommodation with online and on the phone. Definitly a budget place - if you don't like seeing cockroaches or geckos maybe find somewhere else, we were personally delighted to see Everything the Philippines had to offer -...
This is a really lovely place to stay. It's got a great atmosphere and is a perfect base to base yourself PP.
There is a shared toilet and shower between 3 rooms (up to 8 people) there's also a fridge and a gas cooker in the kitchenette. It's on the first floor with big open windows so you get a...


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My. Iyer helped me with four cases. He work diligently and promptly. He is very professional in what he does. I made a few poor choices and his defense in these cases provided reassurance. While not all cases were dismissed, his work is greatly valued.
Posted by a client
I made a very poor choice earlier this year that resulted in my arrest. I consulted with Mr. Iyer. He made no promises but instead committed to work hard to get me the best possible outcome. He was patient and answered all my questions. He was always very responsive. I was glad I had him because the legal system can be very confusing. In the end, he delivered!
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I am indebted to Mr. V for the diligence he applied to my son's complicated case.
I was also impressed that Mr. V embodies the highest of ethical standards.
He achieved a great result for my son.
Mr. V did truly put our interests first. He was always willing to meet after work, or on weekends.
He knows the law, and he knows the system very well.
He was there for us when we needed him, he is just a good guy and I would absolutely recommend Mr.V to anyone I know who seeks for an attorney that will do the best job of representing you.
On behalf of my family I would like to express our heartfelt thanks to Mr. V for representing my son!!!
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Last year, my son got into some legal trouble and we contacted V. Iyer for assistance with his case. My son's case was complicated because he was already on probation for a previous offense. Thankfully Mr. Iyer accepted the case and agreed to help my son with this matter. Mr. Iyer, worked with me as far as payment for services was concerned which was a big help. We had a lot of questions throughout the process, and he was always very quick to respond to our numerous texts, calls and emails. He was very flexible about meeting times despite having probably had a long day of work himself. He was always willing to meet after work, or on weekends. He knows the law, and he knows the system well. Long story short, he was able to get the charges dropped on my son's charge, which in turn allowed him to complete probation without further trouble. We was there for us when we needed him, and I would recommend him if you ever get into trouble.
Posted by AK
I contacted V shortly after a mistake on a night out with some friends, which escalated into a potentially serious legal matter. Aside from his deep understanding of the law and his expert familiarity with the local and state court systems, V kept me focused and calm, guiding me through every step of the forthcoming process. This is very reassuring for a person who is in a situation of this sort for the first time. V's commitment to me as a client was that he would work diligently on my behalf and keep me apprised every step of the way, and I am happy to say that V outperformed my expectations on all accounts!!!
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When you need representation, you need counsel that will work hard for you and shepherd you through the process, along with doing so in a manner of high ethics and integrity. V is that counsel for me, and if you need him, he will be for you as well.
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Mr. V. Iyer was very helpful in providing us with legal help in a series matter. we was dedicated and kind person and very professional. we recommend him to anyone in need for legal help.
Posted by Dave
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I have seen him in court and outside working his magic. He protects his clients and those who listen to him and do what he says get exceptional results. Thank you Mr. Iyer.
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Ever since we have been working with Mr. Iyer we have had a good experience. He always makes himself available if we have questions or concerns. He is a very honest and straight forward person who is not afraid of fighting for you. Thanks Mr. Iyer.
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I came to know about Mr V while I was looking for a Criminal Defense Lawyer to represent me on a case. Mr V advised me on what not to do during a police investigation. He spoke to the police and was able to convince them in not filing charges. Overall I am happy with how my case was handled. Mr V is highly knowledgeable and was always available whenever I needed to talk to him. I highly recommend him if you are in need of a criminal defense lawyer.
Thanks Mr. V.


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Average climber, likes gear, Trad, Scottish winter, Alpine and sunny European sport climbing.
Dosen't see the attraction of bouldering.
Student studying Engineering.
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Trip to San Vito Lo Capo, Sicily. Amazing variety, length and quality of single pitch routes. Good adventurous multi-pitch.
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Boys Noize Kicks Off American OUT OF THE BLACK Tour in Fort Lauderdale, Nov 23
In anticipation of the first ever live 23 date American tour presented by HARD, Berlin's Boys Noize shares a video which shows a glimps of the so-called 'The Trail Of Rave' which is currently happening in Europe. See the live video, which is filmed and edited by Sodakat HERE via Vice's Noisey.
On Boys Noize's third album Out Of The Black, which came out last month via his own label Boysnoize Records, Alexander Ridha returns with his most proud and critically acclaimed album to date.
Some stand out tracks on the album are the singles "What You Want", "XTC", "Reality", and Snoop Dogg quoted the album closer "Got It" as "Classic Snoop ishh" sounding. On "Ich R U" Boys Noize shows his funky, future-disco, robotic side or as he explains it; "Ich R U" is probably the most melodic one on my new album. If you know some of my tracks like "Yeah", "Jeffer" or "Shine Shine" ...it has that sort of vibe."
"It surprises me that friends or fans sometimes prefer the melodic or softer stuff I do, especially on my remixes and I think "Ich R U" is obviously more of a softer one - but it's still super funky and Disco6000. Again, it has robot vocals, which I prefer to the human one, haha..."
See the Patrick Jean & Sebastien Loghman directed video for "Ich R U" HERE.
HARD Presents: BOYS NOIZE LIVE - OUT OF THE BLACK TOUR 2012
LIVE (*) and DJ Dates
11/23 - Fort Lauderdale, FL @ Revolution *
11/24 – Orlando, FL @ House of Blues *
11/28 – Washington, DC @ Fillmore *
11/30 - New York, NY @ Roseland Ballroom *
12/01 – Philadelphia, PA @ TLA ?*
12/02 – Boston, MA @ House of Blues *
12/03 - South Burlington, VT @ Higher Ground Ballroom
12/06 – Montreal @ Telus Theatre *
12/07 - Toronto @ Sound Academy *
12/08 – Chicago, IL @ Aragon *
12/09 - Maplewood, MN @ Myth
12/10 - St. Louis, MO @ Pageant *
12/11 - Seattle. WA @ Neptune
12/12 - Vancouver, BC @ Venue
12/13 - Portland, OR @ Roseland Theater
12/14 - Oakland, CA @ Fox Theatre *
12/15 - Los Angeles, CA @ Palladium *
12/16 - San Diego, CA @ House of Blues ?*
12/17 - El Paso, TX @ Buchanan's
12/18 – Denver, CO @ Fillmore ?*
12/19 - Austin, TX @ Kingdom
12/20 – Dallas, TX @ House of Blues *
12/21 – Houston, TX @ House of Blues *
Boys Noize - Out Of The Black:
01. What You Want
03. Missile
04. Ich R U
05. Rocky 2
06. Circus Full Of Clowns feat. GIZZLE
07. Conchord feat. Siriusmo
08. Touch It
09. Reality
10. Merlin
11. Stop
12. Got It feat. Snoop Dogg
iTunes: https://itunes.apple.com/us/album/out-of-the-black/id560640596
Beatport: http://www.beatport.com/release/out-of-the-black/972163
Amazon: http://amzn.com/B008ZDNKB0
Official Website: http://www.boysnoize.com
Photo Credit: Dennis Ignatov
About Author
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- Director Ridley Scott Incorporates GoPro into the Making of THE MARTIAN
- Special Screening of Documentary SIR IVAN: I AM PEACEMAN to Kick Off Transgender Awareness Campaign


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October 06, 2015
31 Oct 2012
Playbill.com's new feature series, Their Favorite Things, asks members of the theatre community to share the Broadway performances that most affected them as part of the audience.
This week we spotlight the choices of Tony Award winner Randy Graff, whose Broadway credits include Fiddler on the Roof, A Class Act, High Society, Moon Over Buffalo, Laughter on the 23rd Floor, Falsettos, City of Angels and Les Miserables, among others.
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DAMES AT SEA is a tap-happy celebration of the golden era of movie musicals with a heart as big as the ocean! Directed and choreographed by three-time Tony Award® nominee Randy Skinner (42nd Street, Irving Berlin's White Christmas), this gem of a show has been reimagined for the bright lights of Broadway and taken to glamorous and spectacular new heights! Featuring rollicking tap dancing, love at first sight, joyful music and a boatload of laughs, this glittering musical extravaganza has everything you need for an unforgettable night at the theatre. Sweep your glooms away with DAMES AT SEA!
Click here for details.
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Malibu SeafoodMarch 15Seafood • Malibu, United States
Jumbo Shrimp or Chicken Strips w/fries
Gratitude is the attitude that sets the altitude for your life!
Great birthday parties for kids- they pick them up in a limo!!
Decent prices and much smaller than ChuckECheese so you can keep an eye on ur kids easier!
Awesome cakes!! We've been getting cakes made here for YEARS and every one of them has turned out exactly to our specs. The quality is excellent and the staff very helpful.


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National Museum of the United States Air Force, Dayton
21 Reviews
21 Reviews
The US Air Force Museum is a 'must see' for anyone who enjoys airplanes.
HUGE collection of aircraft, including the only XB-70 Valkyrie in existance. They are working on building a 3rd wing to this, so plan on a full day, possibly even more.
The United States Air Force museum located in Dayton is the oldest and largest aviation museum in the world. It is free an open to the public most days of the week from 9 to 5, except for Christmas, New Years day, and Thanksgiving. I recently toured it with my boys. They enjoyed it, but would probably have enjoyed it more if we had gone on one of the family weekends. They were eager to tour the gift shop and got tired of looking at all the planes. Nevertheless, they enjoyed sitting in some of the cockpits of planes set up for that purpose. Older children and adults would enjoy the museum.
The museum houses an extensive display of military planes starting with a reproduction Wright brothers plane through current era planes, such as a Stealth Fighter. Over three hundred aircraft are displayed along with photographs, and other displays. While we were visiting recently, the museum had special exhibits on the Korean War and military prisoners the Nazi's housed in labor camps during World War II. The museum also has an Omnimax theater, a monument garden, and sponsors special concerts and other events. Nearby, at the Wright-Paterson Air Force base, a special collection of presidential planes including FDR's plane, Truman's plane, and the Airforce 1, used by Kennedy, Johnson and Nixon is housed along with experimental planes. President Johnson was sworn in as President following JFK's assassination on the most recent of these "Air Force One" planes. A free pass is available to view the hanger at Wright Patterson at the Air Force museum. I enjoyed looking inside the Presidential planes, but could not get any photos because of the small space and the plexiglass around the seating compartments.
Visit the United States Air Force Museum at Wright Patterson Air Force Base.
As is stated my introduction to Dayton, this museum is something that you do not want to miss. Whether you like military aviation or not you will doubtless love this place. It details the entire history of military aviation from WWI through present-day missions. The museum is also massive and will take more than one day to see it all. It also has sections on space flight and presidential aircraft. You can actually tour several different presidents' Air Force One planes. It has famous spy aircraft, pursuit jet fighters, WWI and WWII aircraft, and much, much more for you to enjoy. Another bonus to your visit here is that admission and parking are entirely free - or paid for with your tax dollars; however you choose to look at it.
This is a huge museum featuring military aircraft from a replica of the first Wright flyer to F-22s and F-117s. A must see for any Aviation fan. Best part it's free.
If your an aircraft aficianado then the Air Force Museum in Wright-Patterson AFB in Dayton is the place for you
Simply the most comprehensive collection of United States Air Force airplanes and memorabilia. Rivals the Smithsonian and includes a voluminous research floor, IMAX theater and book store.
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|Home » Discuss » The DU Lounge
|freshwest (1000+ posts) Send PM | Profile | Ignore
|Thu Nov-24-11 12:10 PM
Response to Original message
|1. Someone gave me mine, too. Some sweet souls here.
|Printer Friendly | Permalink | Reply | Top
|-Haven't been posting much and just noticed that some generous soul has gotten me a star
|abq e streeter
|Nov-24-11 12:05 PM
|- Someone gave me mine, too. Some sweet souls here.
|Nov-24-11 12:10 PM
|- there sure are.
|abq e streeter
|Nov-24-11 12:12 PM
|- couldn't happen to a nicer guy
|Capn Sunshine
|Nov-24-11 04:03 PM
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|4 reviews in total
I first saw Sytten in Denmark when I was about 19. Being the right age and in the right place, I LOVED it. It captured the Denmark I had come to love better than any other Danish film. Back in the States at age 23, the film turned up in my college-town theater, so I took my fiancé in order to "share some of my Danish experience." What I thought was a fun, boyish romp, was for her, the dirtiest thing she had ever seen. Now that my own sons are past that age, I'd love to see it again to see how it plays in my memory. I particularly remember the funniest scene with the lad struggling with masturbation and the local priest trying to, literally, help him out with it, "So we can repent together later." Then, after his own awkward experience with one of the farm girls, entering the farm house and seeing the maid on her knees scrubbing the floor. She had been coming on to him even though she was old enough to be his mother, but now with some experience under his belt, he quietly sneaked up behind her and gave her the thrill of her life. The older woman/young boy is a recurring theme in the Danish coming of age novels I've read, and this supposed autobiographical portrait of the writer fit right in.
The film is set in the Danish provincial town of Nybro, though it opens
and closes in Copenhagen. It is 1913 and the Danes smell war in the air
- though they are uncertain whether it will involve them or not.
The film falls very oddly between being a not-very-interesting sex-comedy (all the women seem anxious to get laid, but we see very little except copious lingerie from any of them) and a much more intriguing montage of village life reacting to imminent war with a mixture of confusion and indifference.
One could certainly watch the film without any attention to the erotic element. Sytten contains one of the few accurate loss-of-virginity scenes before Catherine Breillat, but all the rest of the porn is so anodyne as to be tedious. The photography of Nybro is lovingly attentive to detail though, and the attempt to capture belle epoque class certainty and political confusion if genuinely thought provoking.
I thought this was a very good film, though I can see why it will disappoint almost everyone who watches it. The erotic content is either silly or annoyingly accurate (the people who watch erotic films seldom have any interest in real sex) but it certainly gets in the way of the rather unusual gentle nostalgia which should have been the film's forte.
The other films I've seen from Anneliese Meineche were all just as confused.
I saw this film approximately 35 years ago and I have fond memories of its light hearted and liberal plot concerning adolescent sexuality.Much of the criticisms made of it are accurate enough but to concentrate on the positive aspects of this film I would maintain that its joyful celebration of sexually confident women attempting to seduce a young guy is every adolescents fantasy and accurately portrayed in this film.various scenes are recalled in memory..the maid viewing him as potential lover..a woman on the train eating an apple seductively...to repeat the wholesale celebration of sexuality in a liberal fearless context.That does it for me.
An indescribably crude slice of Danish humor that shocked the prudes in the U.S. in 1967, complete with male and female nudity (including a brief female "full frontal" shot), all of which kept the film in "art house" venues. The plot has a virginal schoolboy Jacob (played by a somewhat overaged-looking Ole Soltoft) visiting relatives for summer and within one month goes from innocence to satyriasis. The family maid attempts to seduce him, and he is drawn into his own sexual awakening by his cousin, in the only truly erotic sequence of the movie, which comes in the final ten minutes or so. ERIC SOYA'S 17 is not subtle, either. It plays as a slapstick comedy and it seems that the actors were instructed to mug and roll their eyes as much as possible. There is even a syrupy title song, "Seventeen," sung in Ed Ames style to an ersatz 101 Strings accompaniment. That said, the film will not appeal to viewers raised on 1980s-style sex comedies, as ERIC SOYA'S 17 is slow-moving and "arty" in the manner of most 1960s cinematic erotica.
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Just curious for all of you ladies out there who are already moms - what are some baby items you feel like are a waste of money. The first thing that came to my mind is a classic bassinet type stroller - I feel like they are only useful for a short period of time. I'm not a mom yet so would like to know what are must-haves versus not-needed. Thanks.
Your opinions on unnecessary baby gear
I think if the stroller comes with it then great! if not then no it is not necessary at all.
I found I rarely use the changing table- some love it though. You could easily just buy a changing pad and put it on a dresser or a good ol bed or floor works just as well too ;)
I hear wipe warmers are ridiculous, i never bought one. Diaper genie is on that same list too.
Baby jeans! BABY JEANS are my biggest pet peave, so silly, they look ridiculous and are obviously horribly uncomfortable. When the kid can walk jeans are ok but before then i think its so unnecessary and borderline cruel.
Briar married to Pedro 2005
5 yr old 3 yr old 2 yr old and new baby Dec 2013
&& our love made it 3. <3
Isabella Nicole made her way into this world on July 23rd, 2012.
My precious 32 weeker.
Wipes warmers! I always think of my friends daughter, they had a wipes warmer at home but when she would have to change her son somewhere other than home he would scream bloody murder because the wipes were 'cold'.
My daughter hated her tummy time mat, some babies might like them though.
Rich(34) & Holly(33) DD Peyton 5/28/08
DS Collin 12/4/13 Foster mom to J 7/25/08
Surprise Squish Coming Soon! EDD 6/23/15
Baby shoes, I don't know why but I got a million pairs for my daughter. She doesn't even wear shoes regularly now at 20 months.
Remember, it's only a crime if it displeases the man.
EDD 12/25/13, Hoping for our boy.
What I use:
Rock n play sleeper
Ring sling
Cloth diapers and wet bag
Clothes (not too many NB but a few)
Umbrella stroller and high chair later
Maybe a swing or bouncer seat. I sold my swing after number two, kept the bouncer seat. Mainly cause you don't get much money out of them.
We now use our crib. It is side carred to our bed since we have two LOs in our bed.
Gracelyn (10/6/10), Levi (4/19/12), and #3 (due 12/29/13) but coming a few weeks early
yes baby shoes are silly too- they almost never fit and/or stay on. Invest in some good well fitting well staying socks
Briar married to Pedro 2005
5 yr old 3 yr old 2 yr old and new baby Dec 2013


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Buy properties in Palatine Road, West Didsbury, Didsbury, Manchester M20 - 4 bedrooms
Property type
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Offers in region of £350,000
Trafalgar Place, Palatine Road, West Didsbury, Manchester, Greater Manchester M20Town house for sale - 4 bedrooms
A striking modern townhouse, stylishly presented throughout, located on an exclusive development within walking distance of west didsbury village. 1144 sq ft. The accommodation consists of a storm porch, entrance hallway, modern breakfast kitchen, a ... More details
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- Burnage (0.9 miles)
- East Didsbury (1.2 miles)
Marketed by Philip James Kennedy, M20. Call 0161 937 6789Offers in region of £490,000
Old Lansdowne Road, Manchester, Greater Manchester M20Semi-detached house for sale - 4 bedrooms
Four bedrooms, two bathrooms and features two reception rooms. Gardens to the front and rear . Great location close to all shops and transport links. The property is converted into several apartments More details
Note: Distances are straight line measurements
- Burnage (1.1 miles)
- East Didsbury (1.3 miles)
Marketed by Bridgfords - Didsbury, M20. Call 0161 884 0166Offers in region of £869,950
Marlowe Drive, Didsbury, Manchester, Greater Manchester M20Detached house for sale - 4 bedrooms
An imposing detached property, located within the blackburn park conservation area, elegantly proportioned and beautifully presented, with A westerly facing garden. 2206 sq ft. The accommodation consists; entrance porch, reception hallway, dining ... More details
Note: Distances are straight line measurements
- Burnage (0.8 miles)
- East Didsbury (1.0 mile)
Marketed by Philip James Kennedy, M20. Call 0161 937 6789


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HN-SOO291 Source Outdoor
Source Outdoor Tuscanna Patio Dining Set - Seats 4Item # HN-SOO291
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- Modern, bold set with round shaped bistro table and 4 chairs
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Your love of modern furniture and bold lines doesn't have to go out the window when it comes to patio furniture with the Source Outdoor Tuscanna Patio Dining Set - Seats 4. Sophisticated and comfortable, this gorgeous dining set fuses together contemporary styling with a classic patio dining set. Able to seat up to four people, this table is ideal for family dinners and spending time with friends outdoors. With a thick aluminum frame wrapped in weather and UV resistant hand-woven resin wicker, t


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E: firstname.lastname@example.com
O: McKenna Hall
Dr. Joseph Williams, a Microsoft executive, has been named dean of SPU's School of Business, Government, and Economics.
Posted: Thursday, June 06, 2013
3307 3rd Ave West, Seattle WA 98119-1997
206-281-2000 | 1-800-366-1234 (toll-free)
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Founded in 1891, Seattle Pacific University is a leading Christian university that equips people to engage the culture and change the world. Learn more
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SEA took a softer, more feminine approach for Pre-Fall. This mini-length white lace skirt has been embroidered in blue and black and is pleated to create a flattering shape. Finished with discreet slit pockets and a soft cotton and silk-blend lining, this style looks especially chic worn with the matching top.
White lace Concealed hook and zip fastening at back 65% cotton, 35% nylon; lining: 70% cotton, 30% silkDry clean
Product code: 449673 - Need help? Contact us


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Encyclopedia of Soils in the Environment, Four-Volume Set
- Daniel Hillel, Dept. of Plant and Soil Sciences, University of Massachusetts, U.S.A.
Researchers, scientists, & professionals in the soil sciences, earth sciences, agronomy, and ecology
Book information
- Published: October 2004
- Imprint: ACADEMIC PRESS
"It has been talked about for a while but, now, it has been published: a new encyclopedia of soils...impressive and comprehensive...this encyclopedia is a blessing...well-written, and very useful to refresh knowledge or gain some new. It will be a standard reference book for years to come." -Alfred E. Hartemink, ISRIC- World Soil Information, for GEODERMA, May 2005 "Very well written as a whole, with appropriate illustrations and additional readings...an excellent resource for libraries supporting agriculture." -CHOICE, September 2005 "A check on publications by the authors shows an impressive list of articles and books...covers diverse subject areas from environmental issues, management, agro-forestry techniques, food production, climate change, nutrient depletion, microbial ecology, modeling, soil strength, and more. The illustrations and other graphics are well done and add visual guides to the diverse subjects...This encyclopedia is recommended for college and research libraries. Undergraduates will find this a great resource for coursework both on the environment and soil or agriculture courses." -E-STREAMS, June 2005


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Apple introduces new iPad accessories, cables
Alongside the iPad mini and fourth-generation iPad, Apple today introduced a handful of new accessories and cables including a new polyurethane iPad mini Smart Cover, Lightning to USB Camera Adapter, Lightning to SD Card Camera Reader, Lightning to Digital AV Adapter, and Lightning to VGA Adapter.
For the iPad mini, a shrunken version of the iPad Smart Cover was announced. iPad mini Smart Cover functions in the same way as Apple's previous magnetic lid but forgoes the metal spine. It comes in dark gray, light gray, pink, green, blue, and (PRODUCT) RED variations.
Its iPad Camera Connection Kit, formerly coming with two adapters inside, has been split into two separate adapters: the Lightning to USB Camera Adapter and Lightning to SD Card Camera Reader. They work with both new iPad models.
The HDMI port-equipped Apple Digital AV Adapter and Apple VGA Adapter have also been updated with support for Lightning connectors. They've been renamed as the Lightning to Digital AV Adapter and Lightning to VGA Adapter, respectively, and cost $49 each. This represents a price increase of $10 for the Digital AV model and $20 for the VGA cable.
To support the revised third-generation iPad's increased charging requirements, Apple also released a 12W USB Power Adapter ($19). The adapter is packaged alone without a Lightning to USB Cable or any other cable, much like the company's 5W USB Power Adapter. It allows the iPad to charge at a faster rate than the iPad 10W USB Power Adapter that's been in use since the first-generation model of the tablet, and because it omits the additional cable, it sells for a lower price.
Related Stories
- Apple TV, iPad Pro to be sold online in late October, in stores early November?
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Recent News
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- iBooks adds exclusive enhanced editions of Harry Potter series
- Report: Barclays to launch Apple Pay support in the UK early next year
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- Antitrust monitor: Apple is 'its own worst enemy'
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CONTACT: Amgen
Carrie Deverell: +41 41 3690 308 (E.U. media)
Christine Regan: +1 805-447-5476 (U.S. media)
Arvind Sood: +1 805-447-1060 (investors)
(Logo http://photos.prnewswire.com/prnh/20081015/AMGENLOGO)
(i) Peeters, M et al. Randomized Phase III Study of Panitumumab With Fluorouracil, Leucovorin, and Irinotecan (FOLFIRI) Compared With FOLFIRI Alone As Second-Line Treatment in Patients With Metastatic Colorectal Cancer. J Clin Oncol 28, 2010.
(ii) Adverse event rates were comparable across arms with the exception of known toxicities associated with EGFR therapy such as rash, diarrhea and hypomagnesemia. Vectibix-related grade 3 infusion reactions were reported for two patients (less than one percent).
(iii) In general, adverse events rates were comparable across arms with the exception of known toxicities associated with anti-epidermal growth factor receptor (EGFR) therapy such as rash, diarrhea, and hypomagnesemia. Vectibix-related grade 3/4 infusion reactions were reported in less than one percent of patients.
(iv) Malumbres, M. and Barbacid, M. RAS oncogenes: the first 30 years. Nature Reviews Cancer. 3:459-65, 2003.
(v) Karapentis C, S. Snell, L, E. The Laboratory Assessment of KRAS Mutation Status in Colorectal Cancer. Asia, Pacific Journal of Oncology and Hematology. 2010.
(vi) Friday BB and Adjei AA. K-ras as
|SOURCE Amgen
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"It seems like the more people I talk to, the more I realize just how good of an engineering program LSSU has. I appreciate your classes, your ability to make learning an enjoyable experience, and the hands-on attitude of LSSU as a whole. I am very glad I chose LSSU."
Jake Weinmann
Controls Engineer, ADD Software/Fanuc Robotics
Faculty Advisor:
Industrial Contact:
Team IVI designed a medical thrombosis prevention prototype to decrease the risk of lower-extremity venous thrombosis, blood clots in the leg veins of human individuals. It improves blood circulation by applying pressure to different parts of the patient's lower extremities in a timed sequence. The parts of the device include two cuffs: one for the upper thigh and another around the foot along with a controller to synchronize the operation with an air pressure supply unit. It allows medical professionals to conduct clinical trials and produce documentation to assess the effectiveness and safety of the device.
Fourth Place
Pick-up Trucks and Aerodynamic Drag CFD Analysis
Presentation by senior Robert Camp based on research work done with Dr. Mokhtar during summer 2008.
An engineer, like all professionals, must possess a well-developed ability to communicate, both orally and in writing. This competition is designed to emphasize the value of an ability to deliver oral presentations.


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China's Localities Feel Pinch of Tighter Credit
BEIJING—China's local governments, which ran up huge debts during the record-breaking lending spree of the past year, are now feeling the pinch as authorities in Beijing tighten credit.
Off-balance-sheet borrowing by cities, counties and provinces helped finance a wave of public-works construction last year that contributed to the nation's growth. Now regulators in Beijing, worried that local governments won't be able to pay back all their loans, are increasing their scrutiny of this kind of debt.
That's likely to constrain the number of infrastructure projects that local governments launch this year, meaning a smaller boost to the economy as the nation's stimulus program enters its second year. The lion's share of that stimulus consists not of government funding but enormous lending by state banks.
"While tighter credit is unlikely to affect most ongoing investment projects, especially since many stocked up on financing in 2009, local governments will have their work cut out to start new projects this year," said Stephen Green, an economist for Standard Chartered STAN 5.08 % in Shanghai.
Estimates of the total debt accumulated by investment vehicles set up by local governments range from six trillion yuan (around $878 billion) widely cited in the Chinese media, to the 11 trillion yuan calculated by Northwestern University professor Victor Shih. Those sums—on the same order of magnitude as all the official debt of China's central government—have drawn high-level concern.
"If this is handled poorly it could result in local government financing platforms being unable to repay their debts, creating bad assets for banks and other problems," central bank Gov. Zhou Xiaochuan warned in January.
Liu Mingkang, China's chief bank regulator, followed up in a nationwide conference call with bank executives on Jan. 26, telling them to "fully assess and effectively guard against risks from local government financing platforms."
The Shanghai Securities News reported Wednesday, citing unnamed sources, that banks had been ordered to stop issuing new loans to investment vehicles that are backed only by local governments' future revenue and have no registered capital.
Several Chinese banks contacted Wednesday didn't respond to queries about such lending.
Although local governments in China are generally prohibited from going into debt, most manage to circumvent the law by setting up their own companies to do the borrowing. Supported by land holdings and the promises of officials, such firms found plenty of obliging banks during the recent lending spree. And with most tax revenue going to central government coffers in Beijing, local agencies had no other way of paying for the new railroads,bridges and dams called for in the national stimulus. plan.
The central government has taken several steps to slow down new bank lending this year. Amid the more risk-averse atmosphere, local government companies no longer are favored customers. The country's largest bank, Industrial & Commercial Bank of China, said this month it will "strictly manage" lending to "urban infrastructure projects carried out by local government fundraising platforms."
Local capital markets are also becoming less welcoming. In 2009, domestic bond issues by municipal investment companies totaled 121.2 billion yuan, according to the National Development and Reform Commission, double the pace of previous years. But these bond issues have already fallen off from their peak in early-2009, and could slow further.
Regulators have raised the bar for new bond applications by companies linked to lower-level governments with weaker finances, a person familiar with the situation said. However, the central government is still processing applications for bond issues from these companies, as there is a backlog from last year. "The government isn't shutting down the bond market," this person said. "But there is a growing awareness of credit risk."
The NDRC declined to comment, and the Ministry of Finance didn't respond to a request for comment.
Local governments' plans for the year appear to have factored in a tighter fundraising environment. The Wall Street Journal examined the government work reports for 2010 that China's 31 provinces have published over the past two months. Of the 28 provinces that announced a formal target for investment growth this year, 26 are aiming for lower growth in 2010 than in 2009; the remaining two want to keep growth steady. On average, the provinces are targeting an increase in investment for 2010 that is 11 percentage points below what they achieved in 2009.
Curbing local governments' reliance on off-balance-sheet debt isn't a simple task, because they face real financial pressures. For now, some local officials seem willing to accept the central government's tougher line. "We will standardize all varieties of government financing platforms, and focus on preventing financial risks," Shandong Gov. Jiang Daming said in a January speech. Others are still reluctant: Guangxi Gov. Ma Biao said in a speech that he will "give full play to the role of investment financing platforms and expand the scale of fundraising."
The central government's concern is understandable, since it will ultimately have to pick up the tab for any debts the local governments can't sort out themselves. "Beijing is still responsible for the debt risk of local governments, and they are not allowed to go bankrupt under any circumstances," Xu Lin, director of the fiscal and financial affairs department of the NDRC, wrote in a recent article.
Write to Andrew Batson at firstname.lastname@example.com


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The season's upon us. It's that time of year. So close your eyes, Nats fans, and forget sugar plums. Dream of this lineup for just a moment.
Denard Span, CF. Ryan Zimmerman, 3B. Bryce Harper, LF. Robinson Cano, 2B. Jayson Werth, RF. Ian Desmond, SS. Adam LaRoche, 1B. Wilson Ramos, C. Pitcher du jour.
That's a quality leadoff hitter based on what he showed over the final two months of the 2013 season, followed by seven players capable of 25-plus home runs in a season.
SEE ALSO: Doug Fister addition lets Nationals rest easy with rotation
The only problem? The second baseman isn't a member of the team.
Yet. Or likely ever.
The odds of Cano, a free agent who has had a brilliant career with the Yankees, joining the Nats are only slightly higher than the odds of a Ferrari showing up under a certain tree in Accokeek, Md.
SEE ALSO: Who's on second for Nats? Rizzo mum on Robinson Cano
But what's a holiday season without a few dreams? And this is one dream the Nats really should try to make a reality.
Cano has been one of the best players in baseball for a long time, maybe the best. He's won two Gold Gloves and five Silver Slugger awards. He's had at least 25 home runs every year since 2009 and driven in at least 107 runs three of the past four seasons. He's had 41 or more doubles seven of the past eight seasons. He's durable, too, having played at least 159 games for seven straight years.
Pause a moment to let those numbers sink in, because the next set of numbers may make heads explode.
For his efforts as a Yankee, he's looking to cash in to the tune of $250 million over 10 or so years. Odds are, he'll get it somewhere and if those are the terms, the Nats should take a pass. As good as the 31-year-old Cano is, paying him that kind of money as he nudges past the 40-year-old mark is not smart.
But if they can get him for the same annual salary over a five- or six-year contract? Buy a gold fountain pen and beg the man to sign.
If you are against this because the annual salary is too high, get over that. The Nats can afford it, as can most other teams. Baseball isn't quite like football in its ability to print money, but the sport isn't hurting. The Lerners can do this contract, extend Desmond and pitcher Jordan Zimmermann, plan for the huge contracts Stephen Strasburg and Bryce Harper will eventually command and not lose a bit of sleep.
If you are against this because it may retard the development of Anthony Rendon, get over that in a hurry. Rendon, 23, has plenty of time to develop. He showed during his time with the Nats why there's so much fuss over him as a prospect, and that he still needs some work. A year on the bench as a utility infielder or a year in Class AAA isn't going to kill him.
Can Cano keep this up? That's the chance you take with any player, but there's no reason to think he's close to a regression.
The Nats don't need Cano to be a contender. The roster they boast, particularly with this week's addition of pitcher Doug Fister, is more than strong enough to make them one. Even putting Rendon at seventh in the batting order and moving the others up a spot, it should be a potent offense.
But just as the addition of Fister made a strong rotation into a "wow" rotation, the addition of Cano would make a strong batting lineup a "wow"-to-the-100th-power lineup. Glance up and take another look: You'd have Gold Glove and Silver Slugger potential at almost every spot.
Just because you're already good doesn't mean you shouldn't try to make yourself better. The Nats, by signing Cano, can make themselves a whole heck of a lot better and not really upset the dynamics of their future too much.
Rendon played second last year because the Nats needed a second baseman after Danny Espinosa's disaster of a start. He's a natural third baseman. LaRoche is entering the final year of his contract and it is difficult to see him being brought back in 2015. That might be the time to ask Zimmerman to take a hit for the team and move to first, making room for Rendon at third.
Those are the kinds of things that will work themselves out. To add a player like Cano to this lineup will make it worth whatever juggling needs to be done down the road.
Cano would be a gold-plated bow on what's already a pretty package.


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Review for Yele Haiti, New York, NY, USA
I am concerned about this charity as I made two donations, and never received a receipt or acknowledgment of the funds. This shows bad record-keeping, or at least rudeness to its donors. I also have no idea how the funding was used, and have heard some bad press about the charity's disorganization.
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