text:
Highlights of a Forum Convened by the Comptroller General of the United States:
Strengthening the Use of Risk Management Principles in Homeland Security
GAO-08-627SP: Published: Apr 15, 2008. Publicly Released: Apr 15, 2008.
Additional Materials:
- Highlights Page:
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- Accessible Text:
(202) 512-3000
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From the terrorist attacks of September 11, 2001, to Hurricane Katrina, homeland security risks vary widely. The nation can neither achieve total security nor afford to protect everything against all risks. Managing these risks is especially difficult in today's environment of globalization, increasing security interdependence, and growing fiscal challenges for the federal government. It is increasingly important that organizations effectively target homeland security funding--totaling nearly $65 billion in 2008 federal spending alone--to address the nation's most critical priorities. GAO convened a forum of experts on October 25, 2007, to advance a national dialogue on applying risk management to homeland security. Broadly defined, risk management is a process that helps policymakers assess risk, strategically allocate finite resources, and take actions under conditions of uncertainty. Participants included federal, state, and local officials and risk management experts from the private sector and academia. The forum addressed effective practices, challenges federal agencies face in applying risk management to homeland security, and actions that can strengthen homeland security risk management. Comments expressed during the proceedings do not necessarily represent the views of any one participant, the organizations they represent, or GAO. Participants reviewed a draft of this report and their comments were incorporated, as appropriate.
Forum participants discussed risk management practices currently used or being considered in the private and public sectors, such as the position of chief risk officer (CRO). Private sector CROs communicate information about risks to the business executives responsible for mitigating risks and steer mitigation efforts. A government CRO could address the need forleadership in public sector risk management initiatives, such as improving emergency response and disaster recovery efforts. Participants also noted differences between the public and private sectors. For example, the private sector has the flexibility to choose which risks to insure against, while the public sector must accommodate the public's beliefs about risks and preferences for risk management. Participants identified and ranked the challenges in applying risk management principles to homeland security that in their view were the most critical to address. The top three challenges were (1) improving risk communication, for instance, addressing the lack of a common vocabulary to discuss risk management and lack of a public dialogue about acceptable levels of risk; (2) political obstacles to risk-based resource allocation, such as the reluctance of policymakers, at times, to make difficult choices about what to protect; and (3) lack of strategic thinking, including lack of a governmentwide discussion and strategy related to homeland security investments. When asked to rank which challenge should be addressed first, participants most often selected improving risk communication followed by political obstacles and improving strategic thinking. The expert panel proposed a number of actions to strengthen the use of risk management principles, such as increasing meaningful public outreach to provide fact-based estimates of risk, highlighting the importance of risk management to incoming policymakers, and identifying effective risk assessment practices.
Sep 24, 2015
Biosurveillance:Challenges and Options for the National Biosurveillance Integration CenterGAO-15-793: Published: Sep 24, 2015. Publicly Released: Sep 24, 2015.
Sep 16, 2015
American Red Cross:Disaster Assistance Would Benefit from Oversight through Regular Federal EvaluationGAO-15-565: Published: Sep 9, 2015. Publicly Released: Sep 16, 2015.
Sep 10, 2015
Emergency Management:FEMA Collaborates Effectively with Logistics Partners but Could Strengthen Implementation of Its Capabilities Assessment ToolGAO-15-781: Published: Sep 10, 2015. Publicly Released: Sep 10, 2015.
Aug 12, 2015
Immigrant Investor Program:Additional Actions Needed to Better Assess Fraud Risks and Report Economic BenefitsGAO-15-696: Published: Aug 12, 2015. Publicly Released: Aug 12, 2015.
Jul 30, 2015
Hurricane Sandy:An Investment Strategy Could Help the Federal Government Enhance National Resilience for Future DisastersGAO-15-515: Published: Jul 30, 2015. Publicly Released: Jul 30, 2015.
Jul 22, 2015
Combating Terrorism:State Should Evaluate Its Countering Violent Extremism Program and Set Time Frames for Addressing Evaluation RecommendationsGAO-15-684: Published: Jul 22, 2015. Publicly Released: Jul 22, 2015.
Critical Infrastructure Protection:DHS Action Needed to Verify Some Chemical Facility Information and Manage Compliance ProcessGAO-15-614: Published: Jul 22, 2015. Publicly Released: Jul 22, 2015.
Critical Infrastructure Protection:Preliminary Observations on DHS Efforts to Address Electromagnetic Threats to the Electric GridGAO-15-692T: Published: Jul 22, 2015. Publicly Released: Jul 22, 2015.
Jul 14, 2015
Unaccompanied Alien Children:Actions Needed to Ensure Children Receive Required Care in DHS CustodyGAO-15-521: Published: Jul 14, 2015. Publicly Released: Jul 14, 2015.
Jul 9, 2015
Federal Emergency Management Agency:Additional Planning and Data Collection Could Help Improve Workforce Management EffortsGAO-15-437: Published: Jul 9, 2015. Publicly Released: Jul 9, 2015.
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text: 000 FXUS64 KTSA 051406 AFDTSA AREA FORECAST DISCUSSION NATIONAL WEATHER SERVICE TULSA OK 906 AM CDT MON OCT 5 2015 ...UPDATE... .DISCUSSION... Just sent a quick update to address expected cloud trends through the day and resulting effects on afternoon temperatures. Morning sounding data indicate that the low level moisture across western portions of the forecast area is quite shallow, in stark contrast to how deep the moist layer is in the eastern part. Mesoanalysis indicates the low level moisture gradient is just east of Highway 75 at this time, and given some easterly component to the winds in these levels, this could move west some through the morning but likely not by much. While mid/high cloud cover will have some effect on mixing today, given how shallow the moisture is west of 75, expect that clouds will erode during the afternoon in this region, but hang on through the day across far northeast Oklahoma and into northwest Arkansas. Have raised high temperatures a few degrees from 75 west in expectation of some sun this afternoon, although a below normal afternoon will likely still result. The dry low levels will also have an effect on the light precipitation in the western half of Oklahoma, moving this way. One hour rainfall accumulation from the mesonet and radar estimates show only a couple hundredths of an inch even beneath the deeper echoes near the Texas state line. Measurable precipitation, and perhaps even sprinkly precipitation, will struggle to move east of I-35 so have foregone a sprinkles inclusion with this update. && .PREV DISCUSSION... /ISSUED 606 AM CDT MON OCT 5 2015/ AVIATION... CONCERNING TAF SITES KTUL/KRVS/KBVO/KMLC/KXNA/KFYV/KFSM/KROG. For the 12 Z TAFS, IFR/MVFR ceilings currently across Northeast OKlahoma and Northwest Arkansas will prevail early this morning. Ceilings will slowly lift during the morning, with all sites eventually becoming VFR for the remainder of the forecast period. PREV DISCUSSION... /ISSUED 401 AM CDT MON OCT 5 2015/ DISCUSSION... Another pleasant autumn day will occur today, albeit with quite a bit more cloud cover than we have seen in recent days. A few sprinkles could even occur later this afternoon and evening across mainly northeast Oklahoma, but will not mention in the forecast at this time. A warming trend will occur Tuesday through Thursday, with afternoon high temperatures climbing into the 80s everywhere by Wednesday and Thursday. A cold front will sweep across the area Thursday night and Friday accompanied by scattered showers and thunderstorms. Overall, the models have backed off on the coverage and intensity of the rainfall with the front. The models have finally come into agreement with the previous ECMWF solution on the future evolution of the southwest upper low. They all suggest that this system will cut off well to our southwest and retrograde over the weekend. Thus, this system will be a non-factor for us and have removed pops beyond Friday. By this weekend into early next week, an upper ridge will be building over the southern Plains, and downslope flow will develop in the low levels. This solution is supported by all available models and the pattern favors much above normal temperatures developing late this weekend into early next week. The blended solution has not caught onto this yet, so have raised temperatures to near the very similar GFS and ECMWF MOS solutions. Some 90 degree readings appear likely by Columbus Day. Stayed close to guidance temperatures the next couple days. && .TSA WATCHES/WARNINGS/ADVISORIES... OK...NONE. AR...NONE. && $$ SHORT TERM...22 LONG TERM....16


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|Publication number
|Publication type
|Application number
|Publication date
|28 Jul 2005
|Filing date
|27 Jan 2004
|Priority date
|27 Jan 2004
|Also published as
|Publication number
|Andres Zuluaga, Jeffrey Korn
|Original Assignee
|Infraredx, Inc.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (17), Referenced by (14), Classifications (9), Legal Events (1)
|External Links: USPTO, USPTO Assignment, Espacenet
Probe-based, such as catheter-based, optical systems are applicable to a number of diagnostic and therapeutic medical applications. Optical coherence tomography is used to provide spatial resolution, enabling the imaging of internal structures. Spectroscopy is used to characterize the composition of structures, enabling the diagnosis of medical conditions by differentiating between cancerous, dysplastic, and normal tissue structures, for example. Ablation systems are used to remove or destroy structures within the body to address various diseases, such as tachycardias, tumors, and coronary artery disease, in another example of a probe-based optical system.
For example, in one specific spectroscopic application, an optical source, such as a tunable laser, is used to access or scan a spectral band of interest, such as a scan band in the near infrared wavelengths or 750 nanometers (nm) to 2.5 micrometers (μm). The generated light is used to illuminate tissue in a target area in vivo using the catheter. Diffusely reflected light resulting from the illumination is then collected and transmitted to a detector system, where a spectral response is resolved. The response is used to assess the composition and consequently the state of the tissue.
This system can be used to diagnosis atherosclerosis, and specifically to identify atherosclerotic lesions or plaques. This is an arterial disorder involving the intimae of medium- or large-sized arteries, including the aortic, carotid, coronary, and cerebral arteries.
Diagnostic systems including Raman and fluorescence-based schemes have also been proposed. Other wavelengths, such as visible or the ultraviolet, can also be used.
The probes or catheters for these applications typically have small lateral dimensions. This characteristic allows them to be inserted into incisions or lumen, such as blood vessels, with lower impact or trauma to the patient. The probe's primary function is to convey light to and/or receive light from a target area or area of interest in the patient. In the context of the diagnosis of atherosclerosis, for example, the target areas are regions of the patient's arteries that may exhibit or are at risk for developing atherosclerotic lesions.
For many of these applications, the target areas or areas of interest are located lateral to the probe. That is, in the example of lumens, the probe is advanced through the lumen under analysis until it reaches the areas of interest, which are typically the lumen walls that are adjacent to the probe, i.e., extending parallel to the direction of advance of the probe.
In these applications, "side-firing" probes are used. These probes emit and/or receive light from along the probe's lateral sides. In the example of light emission, the light propagates through the probe, until it reaches the probe or catheter head. The light is then redirected to be emitted radially or in a direction that is orthogonal to the direction of advancement of the probe. In the case of light collection, light from along the probe's lateral sides is collected and then transmitted through the probe to an analyzer where, in the example of spectroscopic analysis in the diagnosis of atherosclerosis, the spectrum of the returning light is resolved in order to determine the composition of the vessel or lumen walls.
In the case of very small gauge devices, angle polishing is typically used to create the side-firing probe. In these examples, the probe or catheter is manufactured from optical fiber. The terminal end of optical fiber is then angle polished so that light propagating down the optical fiber is reflected by the reflective, angular endface to be emitted in a radial direction to a region that is lateral to the probe. In the opposite example of light collection, the angle polished head reflects light directed radially at the probe from regions lateral to the probe to be coupled into the optical fiber's core to be transmitted to the analyzer.
In these applications, the problem of astigmatism has been addressed. Specifically, in the example of side-firing probes fabricated from angle polished fibers, the emitted beam will typically be astigmatic without further beam correcting structures. This is due to the lensing effect of the fiber's curved sidewalls.
Solutions to this astigmatism problem have been proposed. Some have compensated for the curvature of the lateral side of the fiber by adding other beam controlling surfaces. Others have proposed to remove the curvature by polishing.
The manufacture or assembly of these conventional side-firing probes is costly and a time-consuming, however. Moreover, they are typically poorly adapted for multi-fiber probes. These are commonly required, for example, in spectroscopic applications, where one fiber carries light to the target area or area of interest, and then one or more other fibers are used to collect the light from the target area for further analysis. In these spectroscopic applications, it is also sometimes important to control the separation between the emitted beam and the region from where the light is collected. Moreover, different types of fiber are often used to transmit the light to the target area as opposed to collect light from it.
In general, according to one aspect, the invention features a multi fiber optic medical probe. The probe comprises at least two optical fibers. There are side-firing terminations for the at least two optical fibers. Further, beam-shaping apertures are provided for controlling light propagating between the side-firing terminations and a region lateral to the probe.
The provision of the at least two optical fibers allows for multiple optical signals to be transmitted to and/from the target area within the patient. The side-firing terminations allow for the interrogation of regions that are adjacent or lateral to the probe. The beam shaping apertures are provided for controlling light propagating between the side-firing terminations and the region lateral to the probe, in order to control the shape of the emitted beam and also, the direction from which light is collected.
In one embodiment, the at least two optical fibers comprise just two optical fibers. However, in other embodiments, the at least two optical fibers comprise eight or more separate optical fibers.
In the preferred embodiment, the two optical fibers comprise at least one single mode fiber and at least one multi-mode fiber. For example, in the context of the single mode fiber, the core diameter of the optical fiber is usually less than about 10 micrometers, whereas the core diameter of the multi-mode fiber is usually greater than 100 micrometers. Typically, the single mode fiber is used to transmit light to the target area and the multi-mode fiber is used to collect light from the target area.
In the preferred embodiment, the side-firing terminations comprise angled endfaces for the at least two optical fibers. These angled endfaces are preferably formed by polishing. Reflectivity is achieved by the refractive index mismatch between the fiber and air, for example. In other examples, however, the endfaces are metal coated to provide the required reflectivity. In still further examples, multilayer dielectric thin film coatings are used to form the mirrors.
In another embodiment, the side-firing terminations comprise at least one coreless block. This coreless block preferably comprises an angled endface, which can be formed by polishing and metal coated, in one example. The coreless block typically has an index of refraction that is similar to the fiber. It does not have a light guiding core, however. The coreless block is typically attached to a cleaved end of the optical fiber. It is fused to those optical fibers, in one example.
In the preferred embodiment, at least one capillary tube is provided over the side-firing terminations of the at least two optical fibers. The at least one capillary tube provides the beam shaping apertures. In one example, a single capillary tube is used with multiple bores for receiving each of the optical fibers. In another example, a separate capillary tube is placed over each of the optical fibers. The capillary tubes then attach, such as bonded to each other.
An advantage of this embodiment is that it provides a non-astigmatic design and enables rigid alignment between the fibers, leveraging existing connector processes. Assembly is easy, due to the flat, controlled surfaces at the catheter's distal tip, provided by the capillary tubes. It is easy to adjust the separation, and fixturing is also expedited.
In still further embodiments, spacers can be provided between the capillary tubes. Further, a wedge spacer can be used for controlling the angle between the optical axes of the beam shaping apertures for each of the optical fibers. This wedge spacer can be integral with one of the capillary tubes and formed, such as by polishing.
In still other embodiments, the beam shaping apertures are longitudinally offset along an axis of the probe, with respect to each other. This is another way of controlling the distance between the optical axes of one of the beam shaping apertures with respect to another one of the beam shaping apertures.
In general, according to another aspect, the invention also features a method for gathering optical information, using a medical probe. This method comprises transmitting an optical signal in a first optical fiber, and then directing the optical signal radially to a region lateral to the probe, with a side-firing termination. The beam shape of the optical signal is controlled. Finally, optical information is collected with a second optical fiber. The optical information is then transmitted to an analyzer.
The above and other features of the invention including various novel details of construction and combinations of parts, and other advantages, will now be more particularly described with reference to the accompanying drawings and pointed out in the claims. It will be understood that the particular method and device embodying the invention are shown by way of illustration and not as a limitation of the invention. The principles and features of this invention may be employed in various and numerous embodiments without departing from the scope of the invention.
In the accompanying drawings, reference characters refer to the same parts throughout the different views. The drawings are not necessarily to scale; emphasis has instead been placed upon illustrating the principles of the invention. Of the drawings:
In more detail, the probe or catheter head 58 comprises an outer casing 120. In some examples, this outer casing 120 is transmissive to the optical signals of interest or the wavelength ranges of light of interest. In other examples, the casing 120 is generally non-transmissive, but has a transmissive window structure.
Multiple optical fibers extend through the catheter 56 to the catheter's head 58, within the casing 120. In this first embodiment, the two optical fibers 120A, 120B are provided. The terminal ends of these optical fibers 120A, 120B have side-firing terminations 122A, 122B. In one embodiment, these side-firing terminations 122A, 122B are coated to reflect light. In other examples, the index mismatch between the material of the optical fibers 120A, 120B and the medium adjacent to the side-firing terminations 122A, 122B, such as air, provides the required reflectivity. The side-firing terminations 122A, 122B, in effect, couple the optical fibers 120A, 120B to a region 124 that is lateral to the probe head 58.
Specifically, light emanating from the region 124 and directed radially with respect to an toward the fibers is reflected by the side-firing terminations 122A, 122B to be coupled into and propagated by the optical fibers 120A, 120B. Similarly, light propagating through the optical fibers 120A, 120B to the side-firing terminations 122A, 122B is reflected to be directed radially to the region 124, which is lateral to the probe head 58.
One problem that arises, however, with these side-firing terminations for optical fibers is astigmatism in the emitted beam or the collected light, due to the propagation of the light through the curved side walls of the optical fibers 120A, 120B. In the preferred embodiment, beam shaping apertures 126A, 126B are provided for controlling the light propagating between the side-firing terminations 120A, 120B and the region lateral to the probe head 58.
In the first embodiment of
In the preferred embodiment, the optical fibers 120A, 120B have light guiding cores 130A, 130B to transmit the light along the longitudinal length of the catheter 56 with low loss.
In the current embodiment, a combination of multi-mode fiber and single transverse mode fiber is used. Specifically, in the illustrated embodiment, optical fiber 128A is a multi-mode optical fiber, i.e., the fiber supports multiple transverse modes of the wavelength used by the system, which is typically in the infrared wavelengths. Specifically, the fiber's core 130A is large. Preferably, it is larger than 100 micrometers in diameter. This allows it to efficiently collect light from the lateral region 124 and transmit it down the optical fiber 128A.
In contrast, optical fiber 120B is preferably single mode fiber. Specifically, the diameter of the optical fiber's core 130B is preferably less than 10-15 micrometers i.e., the fiber supports only a single transverse mode efficiently of the wavelength used by the system, which is typically in the infrared wavelengths. This allows it to couple to a single mode light source and then, transmit that light to the lateral region 124, with a predictable Gaussian distribution.
In the embodiments illustrated in
Further, adhesive with no spectral features in the wavelength window of the scan band should be selected.
The adhesive is then cured. Finally, the optical fibers 120A, 120B and their respective capillary tubes 128A, 128B are polished together. A coating can finally be added to increase the reflectivity of the side-firing terminations 122A, 122B.
The manufacturing sequence for this embodiment is as follows. Again, the fiber coating is stripped. Then the terminal end of the optical fiber 120 is polished to form the side-firing termination 122. Optical fiber is then inserted into the capillary tube 128 and bonded to the tube such that any space between the fiber's side wall and the inner bore of the capillary tube 128 is filled with index matching epoxy material, especially along the optical axis stretching between the side-firing termination 122 and the beam shaping aperture 126.
The advantage of the third embodiment is that multiple collection multimode optical fibers are provided. The multiple multi-mode fibers 126A, 126C, 126D are located at different longitudinal positions along the longitudinal axis 132 of the probe 56. This allows light emitted by the single mode optical fiber 120B to be collected at multiple distances by the multimode collection optical fibers 120A, 120C, 120D. This allows the spectral response to be collected from different pathlengths.
In one embodiment, the optical fibers 120A, 120B are fused to their respective coreless blocks 142A, 142B. The coreless blocks have angled endfaces that provide the side-firing terminations 122A, 122B. The coreless blocks sidewalls provide the beam shaping apertures 126A, 126B. The reflectivity of these side-firing terminations 122A, 122B can be enhanced with a metal coating or dielectric thin film coatings as described previously.
In the basic example, illustrated in
In the embodiment illustrated in
The width W of this spacer block 152 is used to control the separation between the optical axes 146A, 146B defined by the beam shaping apertures 126B, 126A.
In the embodiment of
The conical bore 160 is fabricated as illustrated in
The system generally comprises the probe, such as, catheter 56, a spectrometer 40, and analyzer 42. In many cases, the catheter rides on a guide wire that is first advanced through the patient's blood vessels.
In more detail, the catheter 56 includes the optical fiber bundle. The catheter 56 is typically inserted into the patient 2 via a peripheral vessel, such as the femoral artery 10. The catheter head 58 is then moved to a desired target area, such as a coronary artery 18 of the heart 16 or the carotid artery 14. In the embodiment, this is achieved by moving the catheter head 58 up through the aorta 12.
When at the desired site, radiation is generated. In the current embodiment optical radiation is generated, preferably by a tunable laser source 44 and tuned over a range covering one or more spectral bands of interest. In other embodiments, one or more broadband sources are used to access the spectral bands of interest. In either case, the optical signals are coupled into the single mode fibers 120-B of the catheter 56 to be transmitted to the catheter head 58.
In the current embodiment, optical radiation in the near infrared (NIR) spectral regions is used for spectroscopy. Exemplary scan bands include 1000 to 1450 nanometers (nm) generally, or 1000 nm to 1350 nm, 1150 nm to 1250 nm, 1175 nm to 1280 nm, and 1190 nm to 1250 nm, more specifically. Other exemplary scan bands include 1660 nm to 1740 nm, and 1630 nm to 1800 nm.
However, in other optical implementations, scan bands appropriate for fluorescence and/or Raman spectroscopy are used. In still other implementations, scan bands in the visible or ultraviolet regions are selected.
In the current embodiment, the returning light is transmitted back down the multimode optical fibers 120-A, C, D of the catheter 56. The returning radiation is provided to a detector system 52, which can comprise one or multiple detectors.
A spectrometer controller 60 monitors the response of the detector system 52, while controlling the source or tunable laser 44 in order to probe the spectral response of a target area, typically on an inner wall of a blood vessel and through the intervening blood or other unwanted signal source, which is typically a fluid.
As a result, the spectrometer controller 60 is able to collect spectra. When the acquisition of the spectra is complete, the spectrometer controller 60 then provides the data to the analyzer 42.
With reference to
In one embodiment, the catheter head 58 spins as illustrated by arrow 110. This allows the catheter head 58 to scan a complete circumference of the vessel wall 24. In some further examples, the catheter head 58 is spun while being drawn-back, in direction 15, through the length of the portion of the vessel being analyzed.
However the spectra are resolved from the returning optical signals 102, the analyzer 42 makes an assessment of the state of the blood vessel wall 24 or other tissue of interest and, specifically area 22 that is opposite the catheter head 58, from collected spectra. The collected spectral response is used to determine whether the region of interest 22 of the blood vessel wall 24 comprises a lipid pool or lipid-rich atheroma, a disrupted plaque, a vulnerable plaque or thin-cap fibroatheroma (TCFA), a fibrotic lesion, a calcific lesion, and/or normal tissue in the current application. This categorized or even quantified information is provided to an operator via a user interface 70, or the raw discrimination or quantification results from the collected spectra are provided to the operator, who then makes the conclusion as to the state of the region of interest 22.
In one embodiment the information provided is in the form of a discrimination threshold that discriminates one classification group from all other spectral features. In another embodiment, the discrimination is between two or more classes from each other. In a further embodiment the information provided can be used to quantify the presence of one or more chemical constituents that comprises the spectral signatures of a normal or diseased blood vessel wall.
In therapeutic applications, the returning optical signals are used to control the therapy, such as the level and pulse period of a delivered beam, such as for ablation.
While this invention has been particularly shown and described with references to preferred embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the scope of the invention encompassed by the appended claims.
|Cited Patent
|Filing date
|Publication date
|8 Feb 1993
|22 Nov 1994
|Xintec Corporation
|Angle firing fiber optic laser scalpel and method of use
|2 Jul 1993
|27 Jun 1995
|Probe having optical fiber for laterally directing laser beam
|26 May 1993
|12 Mar 1996
|Xintec Corporation
|Internal reflectance angle firing fiber optic laser delivery device and method of use
|19 Sep 1994
|8 Oct 1996
|Griffin; Stephen E.
|Side fire laser catheter method and apparatus
|17 Apr 1995
|31 Mar 1998
|Pallarito; Allan L.
|Optical fibre and laser for removal of arterial or vascular obstructions
|8 Jan 1997
|30 Jun 1998
|Coherent, Inc.
|Side firing fiber optic laser probe
|12 Jan 1996
|10 Nov 1998
|Surgical Laser Technologies, Inc.
|Laterally-emitting laser medical device
|23 Mar 1998
|12 Oct 1999
|Duke University
|Lighting instrument, in particular for use in ophthalmologic microsurgery
|16 Sep 1996
|21 Dec 1999
|Focal, Inc.
|Optical fiber diffuser and method of making
|13 Jun 2001
|16 Jul 2002
|Massachusetts Institute Of Technology
|Interferometeric imaging with a grating based phase control optical delay line
|9 Aug 1999
|3 Sep 2002
|Lightlab Imaging, Llc
|Ultra-small optical probes, imaging optics, and methods for using same
|6 Mar 1998
|26 Nov 2002
|The General Hospital Corporation
|Methods and apparatus for forward-directed optical scanning instruments
|22 Jul 1999
|13 May 2003
|Massachusetts Institute Of Technology
|Fiber optic needle probes for optical coherence tomography imaging
|31 May 2001
|5 Dec 2002
|Jing Tang
|Multi-path optical catheter
|1 Nov 2001
|25 Sep 2003
|Andrew Ramsbottom
|Apparatus for providing an image of a remote object accessible only through an aperture of finite diameter
|19 Jun 2002
|25 Dec 2003
|Simon Furnish
|Multi-channel catheter tip
|16 May 2003
|18 Nov 2004
|Jiaying Ma
|Polarizing beam splitter and projection systems using the polarizing beam splitter
|Citing Patent
|Filing date
|Publication date
|12 Mar 2007
|16 Mar 2010
|Medeikon Corporation
|Low reflection lateral output fiber probe
|17 May 2008
|31 May 2011
|Prescient Medical, Inc.
|Multi-channel fiber optic spectroscopy systems employing integrated optics modules
|8 Jun 2008
|31 May 2011
|Prescient Medical, Inc.
|Optical catheter configurations combining raman spectroscopy with optical fiber-based low coherence reflectometry
|5 May 2008
|24 Apr 2012
|Axsun Technologies, Inc.
|Widely-tuned semiconductor laser based gas liquid solid analysis system
|9 Jun 2008
|29 May 2012
|Cynosure, Inc.
|Thermal surgical monitoring
|15 Oct 2009
|4 Sep 2012
|Angiolight, Inc.
|Systems and methods for analysis and treatment of an occluded body lumen
|15 Mar 2012
|18 Jun 2013
|Axsun Technologies, Inc.
|Widely-tunable semiconductor source integrated in windowed hermetic package
|15 Feb 2008
|23 Dec 2014
|Palomar Medical Technologies, Llc
|Method and apparatus for photothermal treatment of tissue at depth
|3 Aug 2009
|12 May 2015
|Cynosure, Inc.
|Picosecond laser apparatus and methods for its operation and use
|27 Mar 2013
|9 Jun 2015
|Boston Scientific Scimed, Inc.
|Method and apparatus for protecting capillary of laser fiber during insertion and reducing metal cap degradation
|29 Sep 2006
|5 Apr 2007
|Cornova, Inc.
|Systems and methods for analysis and treatment of a body lumen
|6 Apr 2007
|6 Dec 2007
|University Of Rochester
|Side-firing linear optic array for interstitial optical therapy and monitoring using compact helical geometry
|27 Mar 2013
|5 Sep 2013
|Boston Scientific Scimed, Inc.
|Method and apparatus for protecting capillary of laser fiber during insertion and reducing metal cap degradation
|9 Jun 2008
|18 Dec 2008
|Cynosure Inc
|Surgical waveguide
|U.S. Classification
|600/476, 600/473, 600/478
|International Classification
|Cooperative Classification
|European Classification
|27 Jan 2004
Owner name: INFRAREDX, INC., MASSACHUSETTS
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:ZULUAGA, ANDRES F.;KORN, JEFREY A.;REEL/FRAME:014939/0069
Effective date: 20040121


text:
Weaver Square Scissor Snaps
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The Weaver® Square Scissor Snaps are great to keep on hand in the barn, truck or trailer. Perfect for use with reins, these clips are durable and versatile. Designed with a nickel plated finish, these clips measure 5/8" across.
The Square Scissor Snaps are sold in bags of two.
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Chiffon skirts that flatter your body are your best friend on shopping sprees with friends, first dates, and much more. The fabric is lightweight, elegant, and feminine, but the garments can also be your...
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Long skirts come in a wide selection of styles and colours, from full A-line skirts to trendy maxi skirts. You can find a variety of long skirts on eBay. Before you shop, know what types of long skirts...


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PeakRanger: A cloud-enabled peak caller for ChIP-seq data
1 Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794, USA
2 Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA
3 Ontario Institute for Cancer Research, MaRS Centre, South Tower, 101 College Street, Suite 800, Toronto, ON M5G 0A3, Canada
4 Institute for Genomics & Systems Biology, The University of Chicago, Cummings Life Sciences Center 431A, 920 East 58th Street, Chicago, IL 60637, USA
BMC Bioinformatics 2011, 12:139 doi:10.1186/1471-2105-12-139Published: 9 May 2011
Chromatin immunoprecipitation (ChIP), coupled with massively parallel short-read sequencing (seq) is used to probe chromatin dynamics. Although there are many algorithms to call peaks from ChIP-seq datasets, most are tuned either to handle punctate sites, such as transcriptional factor binding sites, or broad regions, such as histone modification marks; few can do both. Other algorithms are limited in their configurability, performance on large data sets, and ability to distinguish closely-spaced peaks.
In this paper, we introduce PeakRanger, a peak caller software package that works equally well on punctate and broad sites, can resolve closely-spaced peaks, has excellent performance, and is easily customized. In addition, PeakRanger can be run in a parallel cloud computing environment to obtain extremely high performance on very large data sets. We present a series of benchmarks to evaluate PeakRanger against 10 other peak callers, and demonstrate the performance of PeakRanger on both real and synthetic data sets. We also present real world usages of PeakRanger, including peak-calling in the modENCODE project.
Compared to other peak callers tested, PeakRanger offers improved resolution in distinguishing extremely closely-spaced peaks. PeakRanger has above-average spatial accuracy in terms of identifying the precise location of binding events. PeakRanger also has excellent sensitivity and specificity in all benchmarks evaluated. In addition, PeakRanger offers significant improvements in run time when running on a single processor system, and very marked improvements when allowed to take advantage of the MapReduce parallel environment offered by a cloud computing resource. PeakRanger can be downloaded at the official site of modENCODE project: http://www.modencode.org/software/ranger/ webcite


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|Doc: I'm not going to overdo it
|09.28.09 at 8:50 pm ET
WALTHAM – Before leaving for Newport, R.I. and a week of getting his team in the right frame of mind to actually put some letters and numbers on the blank banner hanging in the corner of the practice facility, Celtics coach Doc Rivers let the media in on a little secret.
"I think camp is important this year but obviously with Kevin coming back, [joining] Rasheed, Paul, Ray, they're not spring chickens," Rivers said. "Perk's [left] shoulder, Tony's [right] foot, we're going to go as hard as we need to but I'm not going to overdo it."
So, the Celtics all got together on Monday and left for Salve Regina University after meeting their media commitments. Kevin Garnett and his right knee, Rasheed Wallace and his new uniform, Paul Pierce, Ray Allen, Tony Allen and his right foot and Kendrick Perkins and his left shoulder joined the rest of their teammates to prepare for a run at getting back on top of the NBA world.
But Rivers was clear about one thing – the NBA Finals are played in June and the playoffs begin in April, something that was reinforced in his mind toward the end of last year.
"Listen, we're going to try and build through the year," Rivers said. "I'm not going to try and get everything in in camp. I can tell you right now that we're going to be behind coming out of camp than where we were last year. I'm more concerned with just preserving. I'm not that concerned about it but that's the way we're going to do it."
As for the new faces like Rasheed Wallace, Marquise Daniels and Shelden Williams all fitting in, Rivers said he'll manage just fine.
"Bottom line is this, everybody is here for one purpose and that's to win and when you're together in that way, I don't think egos are much of a problem," Rivers said. "If you're not together in that way, then egos become a problem. If egos become a problem on this team, then we're not thinking in the right way and that's the way I look at it."
And don't ask about windows of opportunity with this team. There's only one window the Celtics are trying to keep open in the house.
"I'm just worried about the 2010 window right now," Rivers said. "Our goal is to win it this year, that's it. I don't look at windows with this team. Obviously, this team won't be the same in 2012 and 2013. I think we're all smart enough to understand that."
|KG: I'm ready to go
|09.28.09 at 5:13 pm ET
WALTHAM – Kevin Garnett pronounced himself ready for the 2009-10 season during media day for the Boston Celtics on Monday.
"I'm refreshed and ready to go. 5 on 5 starts tomorrow and I'll be ready," said Garnett, who is back after summer surgery to repair bone spurs behind his right knee.
"There are no restrictions," Celtics coach Doc Rivers added. "Right now we have no medical restrictions on any player".
The team left at 4:30 Monday afternoon for Salve Regina University, where they will begin training camp on Tuesday. Celtics captain Paul Pierce said that Garnett looked ready to go from what he saw of him during an informal 5-on-5 pickup game last week.
"It was like a breath of fresh air," Pierce said.
|Sounds of Sheed
|07.09.09 at 10:16 pm ET
WALTHAM – From the '18' on the backboard shot clock above the dais to the '20:10′ on the clock with the number '30' on scoreboard, the Celtics practice facility was decked out on Thursday for the arrival of Rasheed Wallace.
It was arguably the most significant press conference held at Healthpoint, as the Big Three introductory presser of July 2007 was at the Garden.
Eight people were on the dais at that presser as opposed to the to six on Thursday.
Once all the parties sat down, they shared their thoughts on the newest member of the Celtics after he agreed to a three-year deal.
Here's some of the highlights, in audio form.
Rasheed Wallace on why he chose Boston.
Wallace holds no grudges against Detroit, his former team.
Wallace will take to heart suggestions from his wife and kids to try and lessen the number of technicals.
There were also questions asked of Kevin Garnett about the bone spurs removed from behind his right knee, shortly after the Celtics were eliminated by the Orlando Magic.
Garnett said his rehab is going well.
|Pierce sees great things in Wallace, Celtics
|07.09.09 at 8:58 pm ET
WALTHAM – Paul Pierce has found new life in his step and Rasheed Wallace is the reason why.
Pierce couldn't help but think back two summers ago when coming off a 24-win season, the Celtics went out and acquired Ray Allen and Kevin Garnett, leading to a 66-win, NBA Championship campaign 11 months later.
Pierce was up on the dais with Allen and Garnett and had similar thoughts dancing through his head.
"It started two years with Ray and Kevin and I just think with getting Rasheed, it just gives you an extra boost of energy," Pierce said. "Even the last few weeks, it's hard for me to stay out of the gym. I've been coming in, working out, picking up the ball here and there. Just making sure that I'm ready for the upcoming season because I'm excited with the moves that we made." Read the rest of this entry »
|What Ainge Said
|06.23.09 at 2:50 pm ET
WALTHAM – From the future of his starting point guard to the depth of Thursday night's NBA Draft to his hopes for another title run in 2010, Celtics GM Danny Ainge hit on a number of topics on Tuesday in a pre-draft briefing with reporters at the team's training facility at the Sports Authority complex in Waltham.
Here are the highlights: (click on the green for the audio)
First on the future of Rajon Rondo: "He showed up late for a playoff game so we're going to trade him. None of those things is true. We love the kid and we think he's got a very bright future. I don't anticipate any trades happening this offseason involving any of our core players."
"The notion that we might be trading him for some reason other than we think that we could be better or trading any player because of some reason (like) his contract," Ainge said. "I've heard speculation of we're dissatisfied with him or his attitude. That stuff is so false."
This is still a championship caliber team: "We've won 128 games in the last two years. We won 66 games the year before and the championship and then this year we won 62 and had major injuries. So, I think we're crazy (n0t to think we can't win). We're a championship contender for sure the last two years and we feel like we'll be better this year. We'll have a better team on the court.
On Kevin Garnett, who is currently in California and how his progress is going following surgery to remove bone spurs: Read the rest of this entry »
|Ainge: We've had discussions
|06.23.09 at 10:20 am ET
WALTHAM – Danny Ainge has heard all the same rumors that everyone else has about the future of Rajon Rondo.
Only he, as Vice President of Basketball Operations for the Celtics is actually in a position of authority to comment on it and take action.
Ainge will gladly do the first part but as for the second part, don't expect Rondo to be headed out the door anytime soon.
"The notion that we might be trading him because of some reason other than we think we could be better, or trading any other player of some reason, his contract situation," Ainge said Tuesday morning at Healthpoint in Waltham. "I've heard speculation that we're dissatisfied with him or his attitude. That stuff is so false." Read the rest of this entry »
|Bench blues
|05.18.09 at 12:56 am ET
It was the unit that carried them time after time in this playoff run.
But on Sunday night, the Celtics' bench looked like the regulars — drained and empty at the end.
Eddie House, Brian Scalabrine and Stephon Marbury combined for three field goals in 12 attempts, totaling eight points.
"Yes, did we struggle off the bench? Yes," Scalabrine said. "I don't know if it's like you count on us. It's like, once again, I always keep saying, the guys who make plays for us, they make plays for us and it's our job to just knock shots down."
On a night when it looked like Paul Pierce, Glen Davis and Rajon Rondo had hit the wall collectively, the bench needed to be there. Read the rest of this entry »
Latest from Bleacher Report
- Austin Ainge Offers Window to C's Pre-Draft Process
- Trade Possibilities for C's with Draft Approaching
- Latest Buzz Surrounding Jamal Crawford, Kristaps Porzingis, Celtics'...
- Latest NBA Trade Rumors, Buzz
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Can be prepared in 45 minutes or less.
YIELD: Makes about 1 1/3 cups
- 1 large garlic clove, minced and mashed to a paste with 1/4 teaspoon salt
- 1 tablespoon Dijon-style mustard
- 2 tablespoons fresh lemon juice
- 2 tablespoons white-wine vinegar
- 1/3 cup olive oil
- 1/3 cup sour cream
- 3/4 cup crumbled blue cheese (about 3 ounces) plus additional to taste if desired
In a blender or small food processor blend together the garlic paste, the mustard, the lemon juice, the vinegar, and salt and pepper to taste. With the motor running add the oil and blend the mixture until it is combined well. Add the sour cream, 3/4 cup of the cheese, and 2 tablespoons water, or enough to obtain the desired consistency, blend the dressing until it is combined well, and transfer it to a bowl. Stir in the additional cheese. The dressing keeps, covered and chilled, for about 1 week.
my notes
Nutritional Info
- Calories111
- Carbohydrates1 g (0%)
- Fat11 g (17%)
- Protein2 g (4%)
- Saturated Fat3 g (17%)
- Sodium118 mg (5%)
- Polyunsaturated Fat1 g
- Fiber0 g (0%)
- Monounsaturated Fat6 g
- Cholesterol10 mg (3%)


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Upcoming Events
Were: The Westin Resort and Spa, Whistler BC
When: October 3rd. during the Westin's Woof Weekend!
Join us for another year of our famous fundraising dinner, for you and your dog! Both will enjoy a three course meal, silent and live auctions, a red carpet entrance, photo booth, and more.
This event is happening during The Westin Resort and Spa's new Woof Weekend; a whole weekend of events and activities, catered to you and your four-legged best friend...
For more details on Woof Weekend, check out this site: www.westinwhistler.com/woofweekend
All proceeds of the dinner event and the weekend will support the Whistler Animal Shelter.
Thank you for your support!


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Comic releases for the week of June 13, 2013
Witness The New 52 origin of The Dark Knight in Batman: Zero Year. Twists and turns are around every corner as Bruce Wayne takes the final steps toward his destiny. And in the backup story, learn more about how different Gotham City was at this dangerous point in time.
They like the tech, but live for the high stakes. Sisters Molli and Devyn, along with teammates Roman and Kyo-and a stockpile of cutting edge, cyberpunk technology, form a confident team of mercenary thieves able to take on the most formidable jobs around. Yet, when one cyber heist turns out to be more than they bargained for, as a mysterious package and its contents threaten to unravel the group to its core, the menacing worlds of corrupt industry and deadly espionage is unleashed upon them.
Concluding the second arc of MARVEL NOW. Deadpool! Can Wade trust hell to keep their side of his contract? Will all of Deadpool's new friends end up dead because of him? Are turkey sandwiches better than ham? Two of these three questions will be answered.
When 13 satellites fall from the sky in one day, the logical suspect is Lex Luthor — even though he's still locked up in prison. But a stranger question remains: If Superman didn't stop the last satellite from falling, who did? There's a mystery hidden where even Superman can't see it. Can The Man of Steel drag a decades-old secret into the light? Don't miss the debut of this red-hot new series from two of comics' brightest superstars: Scott Snyder and Jim Lee.
Lucille is going to be so jealous.
Other notable new releases FROM Wednesday
Batgirl No. 21
Constantine No. 4
Green Lantern Corps No. 21
Guardians Of Galaxy No. 3
Man Of Steel Day All Star Superman No. 1
My Little Pony Friendship Is Magic No. 8
Nightwing No. 21
Peter Panzerfaust No. 11
Savage Wolverine No. 6
Star Wars No. 6
— New comic information provided by Planet Comics
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News about Hippies, including commentary and archival articles published in The New York Times.
Chronology of Coverage
There are no additional abstracts to display.
'Grandpa Woodstock' Spreads Peace and Love on a Village Green
Allyn Richardson, known as Grandpa Woodstock, spends his days on the village green in Woodstock, N.Y., posing for photographs with tourists during the day and camping at night.
September 6, 2015, Sunday
MORE ON HIPPIES AND: Richardson, Allyn (Grandpa Woodstock) , Woodstock (NY) , Hippies , Woodstock Music Festivals
Ojai's Golden Hour
Southern California's hippie hideaway is welcoming, mostly, its newcomers.
July 12, 2015, Sunday
MORE ON HIPPIES AND: Real Estate and Housing (Residential) , Fashion and Apparel , Celebrities , Agriculture and Farming , Art , Hippies , Ojai (Calif)
Talk of a Sale Fills a Hippie Haven With Bad Vibes
Some in California's Slab City, a squatter colony of ex-hippies, rebels and self-identified misfits, fear they will face dreaded codes and health and sanitation rules.
March 12, 2015, Thursday
MORE ON HIPPIES AND: Squatters , California , Real Estate and Housing (Residential) , Land Use Policies , Hippies
Stephen Gaskin, Hippie Who Founded an Enduring Commune, Dies at 79
Mr. Gaskin was a Marine veteran and hippie leader who founded the Farm, an archetypical hippie commune that has lasted longer than its counterparts while accepting elements of capitalism.
July 3, 2014, Thursday
When Fringes Became Fashion
"Hippie Chic," now at the Museum of Fine Arts, Boston, raises the question of what should be expected from curators picking through clothes from the not-so-distant past.
August 23, 2013, Friday
MORE ON HIPPIES AND: Nineteen Hundred Sixties , Hippies , Fashion and Apparel , Art , Museum of Fine Arts (Boston)
Batik Store, a Vestige of the Hippie Era, Will Fade Away
The closing of the Melting Pot in Boerum Hill seems to be a coda of sorts to the heady days of hippiedom in Brooklyn's more raffish quarters.
July 26, 2013, Friday
MORE ON HIPPIES AND: Brooklyn (NYC) , Hippies , T-Shirts (Apparel) , Fashion and Apparel , Melting Pot
When Hippies Walked the Runways
The "Hippie Chic" exhibition, opening next week at the Museum of Fine Arts, Boston, features the hippie culture as fashion designers saw it.
July 11, 2013, Thursday
MORE ON HIPPIES AND: Hippies , Fashion and Apparel , Museums , Museum of Fine Arts (Boston) , Metropolitan Museum of Art
What Do the '60s Tell Us About Today?
Sampling the reaction to an Op-Ed article by Kurt Andersen.
July 7, 2012, Saturday
MORE ON HIPPIES AND: Nineteen Hundred Sixties , Homosexuality , Women's Rights , Hippies
What Physics Owes the Counterculture
In the 1970s, eccentric young scientists challenged convention and re-energized modern physics.
June 19, 2011, Sunday
MORE ON HIPPIES AND: Physics , Hippies , Nineteen Hundred Seventies , Kaiser, David , Books and Literature
Kickin' Down Madison Ave., Feelin' Groovy
Macy's, General Mills, and Procter & Gamble are among companies with 2009 ad campaigns recalling aspects of the '60s.
June 17, 2009, Wednesday
MORE ON HIPPIES AND: Advertising and Marketing , Nineteen Hundred Sixties , Hippies
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Copyright 2015 Nexstar Broadcasting, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.
Texas Tech Receives 12th Straight National Ranking
DALLAS, Texas (Texas Tech Press Release)– The Texas Tech baseball program is currently fifth in the nation in overall wins (36) and today received three top-30 rankings – giving Tech 12 straight weeks in the national rankings this season.
Tech is ranked 23rd in this week's USA Today Coaches' poll, No. 24 in the National Collegiate Baseball Writers' Association and No. 27 in the Collegiate Baseball national poll.
Tech's highest ranking this week – 23rd by the Coaches– gives the Red Raiders eight national rankings in the poll during the last nine weeks.
Tech received its 12th straight ranking from the NCBWA – this week at No. 23 while falling two spots in the poll from last week's No. 21 ranking.
The Red Raiders are in the Collegiate Baseball poll for back-to-back weeks for the first time this season since the opening two weeks of the 2014 campaign. The Red Raiders moved back one spot this week to No. 27 after receiving a No. 26 spot in the poll last week.
Texas Tech will play one game this week – its final midweek game of the season and its final road game of the regular season at Dallas Baptist on Tuesday, May 6 with first pitch at 2 p.m. at Horner Ballpark.
KLBK On The Road
KLBK is taking the show "On The Road"
Lincoln County Cowboy Symposium
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The Republican Party has been shilling the lie about Family Values and their desire to protect them for years. Most sane people have seen through this lie for a long time. All you have to do is look at the number of mass shootings in our country to see they don't mean a word of it.
Our children are part of what we are supposed to protect in their "Family Values" rhetoric. Since the Republicans are the main culprits who oppose reasonable gun control, it proves beyond reasonable doubt that Family Values means nothing to them at all. They are simply lying to get the crazies votes.
It is time to call them out for not protecting "family values" like they say they are. It is time to put a stop to all of this nonsense before we lose an entire generation of children. If it sounds like I am angry, you are right. I am angry. This does not have to happen in our country.
Nor, does reasonable gun control mean we have taken guns away from citizens. It simply means we can at least make an attempt to keep them out of the hands of people who should not be allowed to carry weapons. It means we can finally show our children that their parents are actually adults interested in protecting them from the evil in the world.
And stop giving me those lame excuses about how "stuff happens" and the Second Amendment and your right to protect yourself and the murder rate in cities like Chicago. That is all cover for not addressing the issues that need to be addressed that you don't want addressed. It is BULLSHIT! None of those arguments have anything to do with these shootings. And, don"t tell me that States have the answer, because States are at the heart of what is happening due to their lax gun laws! In other words, the States are not the solution to the problem, the States ARE the problem.
For example, where do most of the guns that are used in murder in cities come from? Answer: States that do not require proper background checks when purchased online or at gun shows! Then transported to the cites. That is where they come from.
Also, have you notice that the vast majority of these mass killers all got their guns "legally?" That alone should tell you something is wrong with how we allow guns to be purchased in this country. Every time something like this happens, the gun nuts claim that the person who committed this act suffered from mental illness and it wasn't the "gun's" fault. They then tell you that there is no need for universal background checks to try to keep these guns from falling into the hands of those with mental illness.
For once I agree with the gun nuts. It isn't the fault of the gun. It is the fault of the gun nuts, the NRA, the gun manufacturers, and politicians who won't stand up to these wackos. The blood of every dead child, every murdered person, and every suicide that was the result of gun shot lies at their doorsteps! They are the ones allowing these disturbed people to purchase guns to carry out their heinous crimes. They are guilty of abetting the murder of our children and citizens!
We are going to hear the same old bullshit from the right-wing about gun "rights." But you will not hear about your right live freely without the worry of being shot by some nut allowed to purchase a gun legally. Stop listening to them, and fight back. Remember, the blood of our children are on their hands!
This time instead of "offering your prayers" to the victims, show a little backbone and stand up to the gun manufacturers, the NRA and the gun nuts and let us finally do something to stop the madness! As you can see from the proliferation of these tragic events, your child could be next, or even the next mass shooter! How will you be able to live with that if you are willing to do nothing?


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Photo by Steve Cohen
The pickles add crunch and tangy flavor to an old-time favorite.
Leave a Review
YUCK!!!!!!!! This recipe was absolutely disgustingly sweet, and I didn't even add the sugar. I was going to throw it out and my husband asked me to try my cooking wisdom and change some things. Definitely would use dill pickles instead of bread and butter pickles. It made the salad overly sweet. I added 3/4 cup of sour cream to help neutralize the sweetness and 3 TBSP of fresh cut basil. It definitely helped but I won't be using this recipe again.flag if inappropriate
This was by far the best macaroni Salad I have ever had.flag if inappropriate
Loved the recipe! Easy to make, great taste - my new favorite macaroni salad.flag if inappropriate
Not bad. I used less mustard the second time I made it and liked it better..but that's just me.flag if inappropriate
I served this with some grilled burgers and a green salad. The dill pickle added a nice crunch and flavor. I did not have any pimentos though. It was good, but I didn't feel it was anything really unique. I will make it again, but next time try it with pimentos.flag if inappropriate
Would definitely make again. I cut half the mustard, added 3 hard boiled eggs and some sliced black olives. I did not have dill pickles so I added sweet relish. Delicious!flag if inappropriate
This was very much "your mother's macaroni salad." All eaters agreed that it's quite ho-hum. I didn't modify the recipe at all.flag if inappropriate
Nice. I was looking for a variation from the norm, but not too far out there. I used a good kosher pickle finely diced and just a bit of pickle juice to thin out the mayo (didn't have fresh lemons) it was just the kick it needed.flag if inappropriate
3 1/2 forksflag if inappropriate
I have made this recipe a number of times. It is a favorite. Guests always like this dish. A nice change from the "usual" mac salad.flag if inappropriate


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9/15/15 Union Square Community Advisory Committee Meeting
Posted by David Dahlbacka a 2:07 pm on September 13, 2015
The CAC will discuss where they have been, where they are now, where they are going. Topics include the Master Plan, the GLX, and other community concerns. Come and participate in the discussion! More…
Posted in Beat Reporter, Development and Zoning, Transportation | No Comments »


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Look Inside | Enlarge Cover
Jan 16, 1997
| 704 Pages
Jan 16, 1997
| 704 Pages
Young Josiah Paddock, on the run from his past in St. Louis, didn't have much hope of survival. Winter was coming to the Rockies, and if the cold cutting through his city clothes didn't kill him, grizzlies or Indians would. Then his luck tumed. He stumbled across the trail of Ol' Scratch, a solitary mountain man eager enough for company to take the brash youngster under his wing. Pure chance brought Paddock to the old trapper's camp, but it was skill with a gun and a knife that kept them both alive as they rode deep into the majestic land of Blackfeet and Crow, bible-spouting pioneers and sensual woman where only the best and braves survived . . . and only the luckiest rode back again. Carry The Wind is a gripping historical saga set in the Grand Tetons during a time when the horizon never ended and a nation was being born.
"Brutal violence, enduring love, and a passion for the mountains . . . . A book worth reading and an author worth watching."–Library Journal
Terry C. Johnston was born on the plains of Kansas and immersed himself in the history of the early West. His first novel, Carry the Wind, won the Medicine Pipe Bearer's Award from the Western Writers of America, and his… More about Terry C. Johnston
Mass Market Paperback
Published by Domain
Jan 16, 1997
| 704 Pages
| 4-3/16 x 6-7/8
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Through midnight tonight Kohl's is offering an additional 20% off with the coupon code: FLASH20 at checkout. You can also stack the codes below.
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2013 — There is hope that his persistence will eventually pay off as he continued his work on the Ducks' scout teams . . . Converted all three PAT attempts while accumulating 120 yards on two kickoffs in the 2014 Spring Game.
2012 – Kicked a trio of PATs in the 2013 Spring Game.
2011 — Member of the travel squad … Was perfect on three PAT tries and field goals of 37 and 26 yards in the 2012 Spring Game.
2010 — Filled in for Rob Beard in the season opener vs. New Mexico and delivered what turned out to be a Pac-10 season-high for kickers with 18 points on 3-for-4 FG attempts and nine PATs … Converted field goals from 24, 29 and 30 yards and tied UO record by converting 11 consecutive place kicks (FG or PAT) in a single game … Nine PATs vs. Lobos tied modern Oregon record.
PERSONAL — Born Dec. 9, 1991 in Van Nuys, Calif ... son of Everardo and Alma Solis. Family: One sister. High School (Coach): Notre Dame (Kevin Rooney), 2010. Major: Journalism/Advertising.


text:
Cover Girl Professional Super Thick Lash Mascara
602 reviews
76% would repurchase
Package Quality: 3.7
Price: $
Package Quality: 3.7
Price: $
INGREDIENTSWater , Glyceryl Stearate , Ammonium Acrylates Copolymer , Disteardimonium Hectorite , Propylene Glycol , Stearic Acid , Copernicia Cerifera Wax Carnauba , Triethanolamine , Acrylates Copolymer , Synthetic Wax , Polyvinyl Alcohol , Lecithin , Propylene Carbonate , Oleic Acid , Alcohol Denat , Xanthan Gum , Benzyl Alcohol , Phenoxyethanol , Trisodium EDTA , Methylparaben , Glycerin , Panthenol , Ethylparaben , Sodium Laureth Sulfate , Simethicone , Propylparaben , Iron Oxides , Ultramarines May Contain , Titanium Dioxide May Contain
on 8/23/2012 10:23:00 PM
Age: 19-24
Skin: Combination, Fair-Medium, Neutral
Hair: Black, Straight, Medium
Eyes: Brown
I liked this. I purchased the darkest black and still wish it could be a little more black, not as grey, but it's still good. Really lengthening, not much smudging, I don't like the little clump of mascara that always catches onto the tip of the brush as I pull it out, but oh well. also I have asian eyes and this mascara always transfers onto my eyelids during the application process, so gotta watch out for that too. Will try Voluminous Carbon Black in the near future to see how that mascara works for volume.
on 8/16/2012 12:51:00 PM
Age: 36-43
Skin: Oily, Fair, Cool
Hair: Blond, Wavy, Fine
Eyes: Green
I bought this due to the overwhelming love it gets on Makeup Alley. It's not promoted as much as Lash Blast (which I HATE with a passion). I don't hate Lash Blast for its formula; I simply cannot stand the HUGE brush!
I usually only buy waterproof formulas. I couldn't find this in waterproof so I just bought the regular formula in black. It's way down on the bottom of the Cover Girl display, you have to really hunt to find it.
This is good thickening mascara that must be paired with lengthening mascara IMHO. I used Almay Get up and Grow, and then used this on top. The result is gorgeous...long and full lashes! I highly recommend pairing these two mascaras together. Until Makeup Alley, I never in a million years would have used two mascaras together, I never would have mixed two foundations together and I never would have discovered half of the great products that have found. I heart Makeup Alley!
This is good thickening mascara that is easy to remove and does not make your lashes stiff and crunchy.
on 8/15/2012 2:02:00 AM
Age: 30-35
Skin: Combination, Fair, Not Sure
Hair: Red, Other, Other
Eyes: Hazel
Major flaking!!! Ugh. This is my first Cover Girl mascara and probably the last. It applies nicely, with no clumps but just an hour later I find these annoying flakes under my lower lashes. Eight hours later, there is almost no mascara left on my lower lashes. It's all turned into flakes and is sitting on the skin. And I don't rub my eyes at all. I have blond lashes, so it looks horrible with little black particles sitting here and there and white lashes showing through. I will try applying a base first next time and hopefully that will help some. Will not repurchase.
on 8/11/2012 10:58:00 PM
Age: 19-24
Skin: Dry, Fair-Medium, Not Sure
Hair: Brown, Wavy, Medium
Eyes: Brown
It's okay for everyday use. I like how cheap it is, and how it is light and does not clump, flake off, or take off lashes. But it's not super great for me - the very black isn't really "very black" and for me it lengthens much more than any thickening effect, so I still have to fill in a bit with eyeliner. It's so, so un-waterproof that any tears are a disaster, although that does mean that it is super easy to wash off too.
on 8/11/2012 12:24:00 AM
Age: 56 & Over
Skin: Combination, Fair-Medium, Cool
Hair: Brown, Wavy, Coarse
Eyes: Brown
oh yes. definitiely will buy.
this is a great product. no smudges, good consistency, great price
this along with the lashperfection mascara also by cg are soooooo good, it's hard to choose which one to use each day.
look at the bottom of the shelf-they are there
I'm very impressed with these mascaras
on 7/30/2012 1:20:00 AM
Age: 19-24
Skin: Very Oily, Olive, Warm
Hair: Black, Wavy, Fine
Eyes: Brown
I used to use this when I was in high school and that was the last time I used it. I went back to this mascara and I think its okay it's just not my thing. I love lots of volume and although this is called Super Thick it should be called Super Long because it doesn't make my lashes thick it just makes them long. My lashes are already long so I don't need that. I like that it doesn't clump and leave tiny black specks like other mascaras. I would not repurchase this mascara I will be continue using my fave mascara at the moment which is the L'oreal Voluminous mascara.
on 7/21/2012 10:21:00 PM
Age: 19-24
Skin: Sensitive, Fair-Medium, Not Sure
Hair: Brown, Other, Other
Eyes: Blue
My new HG mascara! I have tried a lot of high-end mascaras and prefer this any day. It doesn't clump, flake or smear for me. It thickens and lengthens my lashes with two quick coats! It's also easy to remove, which is important to me. Other mascaras were impossible to remove and I can't stand that.
on 7/17/2012 10:38:00 AM
Age: 19-24
Skin: Combination, Fair, Not Sure
Hair: Blond, Other, Other
Eyes: Blue
I was having one of those awful days where every mascara I tried on my lashes was making them look clumpy and spidery. I had a few in rotation that started out wonderful, and after a week or so began to suck. I had this little baby in my stash since I had picked it up on sale for $4 CAD after reading reviews here on MUA. Just when I was completely desperate and thought that I would be going to work sans mascara (the horror!), I decided to open this up and give it a whirl. Thankfully it saved the day, and I completely understand the awesome ratings that it has received. My lashes are naturally long and quite full, so I like a mascara that just adds a bit more volume and definition, as well as makes my lashes darker. I used this in very black and while I will admit that it is not as black as I would prefer for a night out (like Voluminous Carbon Black for instance, if only it didn't smudge like crazy), it is perfect for everyday wear. I am always trying out new mascaras looking for my HG mascara, and while it is a bit too soon to call this HG, you really cannot beat it for the price. It made my lashes thicker without clumping, and it's completely buildable. Also, it's super easy to wash off with just a normal face cleanser. I actually did a double-take in the mirror after washing my face one morning. I normally need to go over my eye area with some eye MU remover even after my cleanser, but it had removed all of this mascara easily, which is a bonus for me because it saves me time in the morning. Definitely give this one a try! For the price, you can't beat it!
on 7/15/2012 3:42:00 PM
Age: 18 & Under
Skin: Acne-prone, Olive, Warm
Hair: Brunette, Kinky, Coarse
Eyes: Brown
I tried this in Very Black, and loved it! It thickened my lashes, and still looked natural :) This mascara is also very bulidable (w/o clumps), and easy to wash off...it is a bit smudgy though :P I think I'm going to try the waterproof, I was very pleased w/ this though! To me, the price is kind of high...but the quality is worth it imo
on 6/19/2012 9:55:00 PM
Age: 30-35
Skin: Combination, Fair, Not Sure
Hair: Blond, Other, Other
Eyes: Blue
I have tried countless mascaras that are lovely until the inevitable panda eyes. The only mascara that doesn't smudge on me is Blinc, but it leaves me with skinny, straight lashes. I have tried Lancome, Clinique, Smashbox, Diorshow, Tarte, on and on ugh... Never again! I have never found a HG product as the drugstore, but there's a first for everything!
Popular Mascaras
354 Reviews
339 Reviews
428 Reviews
2111 Reviews
66 Reviews
164 Reviews


text:
Briefly: AirPort update; 16M iPods; MacBooksApple has released an update for its AirPort wireless software. Meanwhile, new NPD data suggests the company is on track to sell around 16 million iPods this quarter. And Apple is offering some significantly discounted previous generation MacBook models.
AirPort Update 2006-002
Apple on Wednesday afternoon released AirPort Update 2006-002 (1.3MB), which improves AirPort compatibility for its new line of Core 2 Duo notebook computers.
These models include MacBook Pro (15-inch Core 2 Duo), MacBook Pro (17-inch Core 2 Duo) and MacBook (13-inch Core 2 Duo).
NPD data suggests 15.5M - 16M iPods
In the third of as many research notes released by PiperJaffray analyst Gene Munster on Wednesday, the analyst said an extrapolation of NPD data from the first two months of Apple's December holiday quarter leads him to expect iPod unit sales will total between 15.5 million - 16 million.
"Our analysis of iPod unit data from NPD for the months of October and November leads us to expect iPod shipments in the range of 15.5m-16m for the Dec-06 quarter (our model calls for 14.7m iPods in the quarter and Street consensus is 15.0m)," the analyst wrote.
Munster said the 15.5m-16m unit range is "based on various assumptions" and therefore believes investors should supplement the data point with other information.
Core Duo MacBook Pros at discount
Meanwhile, a tipster points out that Apple through its online store is looking to move some refurbished 15-inch Core Duo MacBook Pro models and is offering considerable discounts as a result.
The Mac maker has discounted both the matte- and glossy-screened version of the previous generation 2.16GHz models by $1000, or a savings of over 40 percent. It's also selling several other refurbished Core Duo 13-inch MacBook and 17-inch MacBook Pro models at discounts of around 30 percent.
On Topic: General
- Apple's angled camera concept could enable virtual keyboard docks
- Microsoft exec jabs at Apple, tweets drawing of 'converged' toaster and refrigerator
- Apple buys machine learning firm Perceptio, suggests development of imaging AI
- Week in review video: Remembering Steve Jobs, build cost of iPhone 6s, 'iRing' & more
- Four years after the death of Steve Jobs, Michael Fassbender talks about portraying an icon


text:
In patients with endocarditis, abscesses may also form in areas surrounding the valves and between the mitral and aortic valve. Surgical treatment of this condition involves removal of infected and dead tissue, drainage and closure of any abscesses, and repair, or more frequently, replacement of the affected valves.
About CryoLife, Inc.
Founded in 1984, CryoLife, Inc. is a leader in the processing and distribution of implantable living human tissues for use in cardiac and vascular surgeries throughout the United States and Canada. The Company recently received FDA clearance for the CryoValve(R) SG pulmonary human heart valve, processed using CryoLife's proprietary SynerGraft(R) Technology. The Company's BioGlue(R) Surgical Adhesive is FDA approved as an adjunct to sutures and staples for use in adult patients in open surgical repair of large vessels. BioGlue is also CE marked in the European Community and approved in Canada and Australia for use in soft tissue repair. CryoLife distributes Hemostase MPH, a hemostatic agent, in much of the U.S. for use in cardiac and vascular surgery and in the United Kingdom and Germany for cardiac, vascular and general surgery, subject to certain exclusions. The Company also distributes the CryoLife-O'Brien(R) stentless porcine heart valve, which is CE marked for distribution within the European Community.
The Statements made in this press release that look forward in time or
that express management's beliefs, expectations or hopes, including
statements regarding the potential benefits of a combination aortic-mitral
allograft heart valve, are forward-looking statements within th
|SOURCE CryoLife, Inc.
Copyright©2008 PR Newswire.
All rights reserved


text:
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Human rights
I read with great interest the opinion piece written by Lise Balk King entitled, "Vern Traversie and the Worst Place
In western South Dakota, it's all about perception. If you are Indian, or appear to be Indian, you are routinely judged by the color of your skin regarding the content of your character. If you are white, there is also a set of assumptions made by those standing on the other side.
Memorial Day in the Osage is a big deal, and deservedly so.
On a sunny September day in New York City in 2007, the United Nations General Assembly gathered to adopt the United Nations Declaration on the Rights o
It was 1:30 p.m.
The Director of the Indian Health Service, Dr. Yvette Roubideaux, recently participated in the White House Forum on Bullying Prevention.
We have been told that a fight against "terrorism" is the reason why the National Defense Authorization Act (NDAA) was passed by Congress, and signed by Preside
On April 23, Foreign Policy published "Why Do They Hate Us?
An oft-heard criticism of the UN Declaration on the Rights of Indigenous Peoples is that it's an "aspirational" document, one with no teeth, enforceability
Stereotypes help market American merchandise for more than a century, and the history of their use and abuse offers a strange and telling story of race relations in this country. Starting with sugar, its long history is interwoven with that of the slave trade.
White privilege in America first stood for wealth advantage, the provenance of white men, no matter how amassed, deserved, shared or inbred. Among its prominent symbols are oil baron J.D.
As a Lakota, I was taught to respect life and death. Living on the reservation, death is all too common. From young to old, we have all felt the pain of losing loved ones before their time.
It seems that we all can be lost on what a "call to action" really entails.