text:
|Número de publicación
|Tipo de publicación
|Número de solicitud
|Número de PCT
|Fecha de publicación
|27 May 2004
|Fecha de presentación
|3 Ago 2001
|Fecha de prioridad
|4 Ago 2000
|Número de publicación
|Andrew Craig, Tim Ho, Michael Millan
|Cesionario original
|Craig Andrew Simon, Ho Tim Chien Ting, Millan Michael John
|Exportar cita
|BiBTeX, EndNote, RefMan
|Citada por (2), Clasificaciones (8), Eventos legales (1)
|Enlaces externos: USPTO, Cesión de USPTO, Espacenet
[0001] This invention relates to a novel pharmaceutical, to a process for the preparation of the pharmaceutical and to the use of the pharmaceutical in medicine.
[0002] European Patent Application, Publication Number 0,306,228 relates to certain thiazolidinedione derivatives disclosed as having hypoglycaemic and hypolipidaemic activity. The compound of example 30 of EP 0,306,228 is 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione (hereinafter also referred to as "Compound (I)").
[0003] International Patent Application, Publication Number WO94/05659 discloses certain salts of the compounds of EP 0,306,228 one of which is the tartrate salt. The preferred salt of WO94/05659 is the maleic acid salt.
[0004] It has now been discovered that Compound (I) forms a novel tartrate salt (hereinafter also referred to as the "Meso-Tartrate").
[0005] The novel Meso-Tartrate is a stable, high melting crystalline material hence is suitable for bulk preparation and handling. The Meso-Tartrate is amenable to large scale pharmaceutical processing, especially in manufacturing processes which require or generate heat, for example milling, fluid bed drying, spray drying, hot melt processing and sterilisation by autoclaving. The Meso-Tartrate can also be prepared by an efficient, economic and reproducible process particularly suited to large-scale preparation.
[0006] The novel Meso-Tartrate also has useful pharmaceutical properties and in particular it is indicated to be useful for the treatment and/or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof.
[0007] Accordingly, the present invention provides 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, meso-tartrate salt or a solvate thereof.
[0008] Suitably, the Meso-Tartrate is a mono-tartrate salt
[0009] Mono tartrate salts also optionally comprise another monovalent salting ion such as an alkali metal or ammonium cation.
[0010] In one favoured aspect, the Meso-Tartrate provides an infrared spectrum substantially in accordance with FIG. 1.
[0011] In one favoured aspect, the Meso-Tartrate provides a Raman spectrum substantially in accordance with FIG. 2.
[0012] In one favoured aspect, the Meso-Tartrate provides an X-Ray powder diffraction pattern (XRPD) substantially in accordance with Table 1 or FIG. 3.
[0013] In one favoured aspect, the Meso-Tartrate provides a Solid State 13C NMR spectrum substantially in accordance with FIG. 4.
[0014] In one favoured aspect, the Meso-Tartrate provides a melting point in the range of from 147 to 157° C., such as 148 to 155° C., for example 148° C., 153° C. and 155° C.
[0015] In a preferred aspect, the invention provides 5-[4-[2-(N-methyl-N-2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, meso-tartrate salt, characterized in that it provides:
[0016] (i) an infrared spectrum substantially in accordance with FIG. 1; and
[0017] (ii) a Raman spectrum substantially in accordance with FIG. 2; and
[0018] (iii) an X-Ray powder diffraction pattern (XRPD) substantially in accordance with Table 1 or FIG. 3; and
[0019] (iv) a Solid State 13C NMR spectrum substantially in accordance with FIG. 4.
[0020] The present invention encompasses the Meso-Tartrate or solvate thereof isolated in pure form or when admixed with other materials. Thus in one aspect there is provided the Meso-Tartrate or solvate thereof in isolated form.
[0021] In a further aspect there is provided the Meso-Tartrate or solvate thereof in a purified form.
[0022] In yet a further aspect there is provided the Meso-Tartrate or solvate thereof in crystalline form.
[0023] Also, the invention provides the Meso-Tartrate or solvate thereof in a solid pharmaceutically acceptable form, such as a solid dosage form, especially when adapted for oral administration.
[0024] Moreover, the invention also provides the Meso-Tartrate or solvate thereof in a pharmaceutically acceptable form, especially in bulk form, such form being particularly capable of pharmaceutical processing, especially in manufacturing processes which require or generate heat, for example milling; for example heat-drying especially fluid-bed drying or a spray drying; for example hot melt processing; for example heat-sterilisation such as autoclaving.
[0025] Furthermore, the invention provides the Meso-Tartrate or solvate thereof in a pharmaceutically acceptable form, especially in bulk form and especially in form having been processed in a manufacturing process requiring or generating heat, for example in a milled form; for example in heat-dried form, especially a fluid-bed dried form or a spray dried form; for example in a form having being hot melt processed; for example in a form having being heat-sterilised by such as autoclaving.
[0026] A suitable solvate is a hydrate.
[0027] The invention also provides a process for preparing the Meso-Tartrate or a solvate thereof, characterised in that 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione (Compound (I)) or a salt thereof, preferably dispersed or dissolved in a suitable solvent, is reacted with a source of meso-tartrate ion and thereafter, if required, a solvate of the resulting Meso-Tartrate is prepared; and the Meso-Tartrate or a solvate thereof is recovered.
[0028] A suitable reaction solvent is a ketone for example acetone, or an ether for example tetrahydrofuran; an alkanol, such as propan-2-ol, a hydrocarbon, such as toluene, an ester, such as ethyl acetate, a nitrile such as acetonitrile, or a halogenated hydrocarbon such as dichloromethane or water, or an organic acid such as acetic acid; or a mixture thereof.
[0029] Conveniently, the source of meso-tartrate ion is meso-tartaric acid. The meso-tartaric acid is preferably added as a solid or in solution, for example in water or a lower alcohol such as methanol, ethanol, or propan-2-ol, or a mixture of solvents. An alternative source of meso-tartrate ion is provided by a suitably soluble base salt of meso-tartaric acid for example ammonium meso-tartrate, or the meso-tartaric acid salt of an amine, for example ethylamine or diethylamine.
[0030] The concentration of Compound (1) is preferably in the range 2 to 25% weight/volume, more preferably in the range 5 to 20%. The concentration of the tartaric acid solutions are preferably in the range of 5 to 125% weight/volume.
[0031] The reaction is usually carried out at ambient temperature or at an elevated temperature, for example at the reflux temperature of the solvent, although any convenient temperature that provides the required product may be employed.
[0032] Solvates, such as hydrates, of the Meso-Tartrate are prepared according to conventional procedures.
[0033] Recovery of the required compound generally comprises crystallisation from an appropriate solvent or mixture of solvents, conveniently the reaction solvent, usually assisted by cooling. For example, the Meso-Tartrate may be crystallised from a ketone such as acetone, or an ether such as tetrahydrofuran or water or a mixture thereof. An improved yield of the salt may be obtained by evaporation of some or all of the solvent or by crystallisation at elevated temperature followed by controlled cooling, optionally in stages. Careful control of precipitation temperature may be used to improve the reproducability of the product form.
[0034] Crystallisation can also be initiated by seeding with crystals of the Meso-Tartrate or a solvate thereof but this is not essential.
[0035] When the mono tartrate salt comprise another monovalent salting ion such as an alkali metal or ammonium cation the said ion is conveniently formed by reacting the mono tartrate salt with a solution of the chosen monovalent salting ion for example a metal or ammonium ion. Alternatively Compound (I) may be treated with a mono tartrate salt of the said monovalent salting ion.
[0036] Compound (I) is prepared according to known procedures, such as those disclosed in EP 0,306,228 and WO94/05659. The disclosures of EP 0,306,228 and WO94/05659 are incorporated herein by reference.
[0037] Meso-tartaric acid is a commercially available compound.
[0038] When used herein the term "Tonset" is generally determined by Differential Scanning Calorimetry and has a meaning generally understood in the art, as for example expressed in Pharmaceutical Thermal Analysis, Techniques and Applications", Ford and Timmins, 1989 as "The temperature corresponding to the intersection of the pre-transition baseline with the extrapolated leading edge of the transition".
[0039] When used herein in respect of certain compounds the term "good flow properties" is suitably characterised by the said compound having a Hausner ratio of less than or equal to 1.5, especially of less than or equal to 1.25.
[0040] "Hausner ratio" is an art accepted term.
[0041] When used herein the term prophylaxis of conditions associated with diabetes mellitus' includes the treatment of conditions such as insulin resistance, impaired glucose tolerance, hyperinsulinaemia and gestational diabetes.
[0042] Diabetes mellitus preferably means Type II diabetes mellitus.
[0043] Conditions associated with diabetes include hyperglycaemia and insulin resistance and obesity. Further conditions associated with diabetes include hypertension, cardiovascular disease, especially atherosclerosis, certain eating disorders, in particular the regulation of appetite and food intake in subjects suffering from disorders associated with under-eating, such as anorexia nervosa, and disorders associated with overeating, such as obesity and anorexia bulimia Additional conditions associated with diabetes include polycystic ovarian syndrome and steroid induced insulin resistance.
[0044] The complications of conditions associated with diabetes mellitus encompassed herein includes renal disease, especially renal disease associated with the development of Type II diabetes including diabetic nephropathy, glomerulonephritis, glomerular sclerosis, nephrotic syndrome, hypertensive nephrosclerosis and end stage renal disease.
[0045] As mentioned above the compound of the invention has useful therapeutic properties: The present invention accordingly provides the Meso-Tartrate or a solvate thereof for use as an active therapeutic substance.
[0046] More particularly, the present invention provides the Meso-Tartrate or a solvate thereof for use in the treatment and/or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof.
[0047] The Meso-Tartrate or a solvate thereof may be administered per se or, preferably, as a pharmaceutical composition also comprising a pharmaceutically acceptable carrier. Suitable methods for formulating the Meso-Tartrate or a solvate thereof are generally those disclosed for Compound (I) in the above mentioned publications.
[0048] Accordingly, the present invention also provides a pharmaceutical composition comprising the Meso-Tartrate or a solvate thereof and a pharmaceutically acceptable carrier therefor.
[0049] The Meso-Tartrate or a solvate thereof is normally administered in unit dosage form.
[0050] The active compound may be administered by any suitable route but usually by the oral or parenteral routes. For such use, the compound will normally be employed in the form of a pharmaceutical composition in association with a pharmaceutical carrier, diluent and/or excipient, although the exact form of the composition will naturally depend on the mode of administration.
[0051] Compositions are prepared by admixture and are suitably adapted for oral, parenteral or topical administration, and as such may be in the form of tablets, capsules, oral liquid preparations, powders, granules, lozenges, pastilles, reconstitutable powders, injectable and infusable solutions or suspensions, suppositories and transdermal devices. Orally administrable compositions are preferred, in particular shaped oral compositions, since they are more convenient for general use.
[0052] Tablets and capsules for oral administration are usually presented in a unit dose, and contain conventional excipients such as binding agents, fillers, diluents, tabletting agents, lubricants, disintegrants, colourants, flavourings, and wetting agents. The tablets may be coated according to well known methods in the art.
[0053] Suitable fillers for use include cellulose, mannitol, lactose and other similar agents. Suitable disintegrants include starch, polyvinylpyrrolidone and starch derivatives such as sodium starch glycollate. Suitable lubricants include, for example, magnesium stearate. Suitable pharmaceutically acceptable wetting agents include sodium lauryl sulphate.
[0054] Solid oral compositions may be prepared by conventional methods of blending, filling, tabletting or the like. Repeated blending operations may be used to distribute the active agent throughout those compositions employing large quantities of fillers. Such operations are, of course, conventional in the art.
[0055] Oral liquid preparations may be in the form of, for example, aqueous or oily suspensions, solutions, emulsions, syrups, or elixirs, or may be presented as a dry product for reconstitution with water or other suitable vehicle before use. Such liquid preparations may contain conventional additives such as suspending agents, for example sorbitol, syrup, methyl cellulose, gelatin, hydroxyethylcellulose, carboxymethyl cellulose, aluminium stearate gel or hydrogenated edible fats, emulsifying agents, for example lecithin, sorbitan monooleate, or acacia; non-aqueous vehicles (which may include edible oils), for example, almond oil, fractionated coconut oil, oily esters such as esters of glycerine, propylene glycol, or ethyl alcohol; preservatives, for example methyl or propyl p-hydroxybenzoate or sorbic acid, and if desired conventional flavouring or colouring agents.
[0056] For parenteral administration, fluid unit dose forms are prepared containing a compound of the present invention and a sterile vehicle. The compound, depending on the vehicle and the concentration, can be either suspended or dissolved. Parenteral solutions are normally prepared by dissolving the active compound in a vehicle and filter sterilising before filling into a suitable vial or ampoule and sealing. Advantageously, adjuvants such as a local anaesthetic, preservatives and buffering agents are also dissolved in the vehicle. To enhance the stability, the composition can be frozen after filling into the vial and the water removed under vacuum.
[0057] Parenteral suspensions are prepared in substantially the same manner except that the active compound is suspended in the vehicle instead of being dissolved and sterilised by exposure to ethylene oxide before suspending in the sterile vehicle. Advantageously, a surfactant or wetting agent is included in the composition to facilitate uniform distribution of the active compound.
[0058] As is common practice, the compositions will usually be accompanied by written or printed directions for use in the medical treatment concerned.
[0059] As used herein the term 'pharmaceutically acceptable' embraces compounds, compositions and ingredients for both human and veterinary use: for example the term 'pharmaceutically acceptable salt' embraces a veterinarily acceptable salt.
[0060] The present invention further provides a method for the treatment and/or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof, in a human or non-human mammal which comprises administering an effective, non-toxic, amount of Meso-Tartrate or a solvate thereof to a human or non-human mammal in need thereof.
[0061] Conveniently, the active ingredient may be administered as a pharmaceutical composition hereinbefore defined, and this forms a particular aspect of the present invention.
[0062] In a further aspect the present invention provides the use of Meso-Tartrate or a solvate thereof for the manufacture of a medicament for the treatment and/or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof.
[0063] In the treatment and/or prophylaxis of diabetes mellitus, conditions associated with diabetes mellitus and certain complications thereof the Meso-Tartrate or a solvate thereof may be taken in amounts so as to provide Compound (1) in suitable doses, such as those disclosed in EP 0,306,228, WO94/05659 or WO98/55122.
[0064] No adverse toxicological effects are indicated in the above mentioned treatments for the compound of the invention.
[0065] The following examples illustrate the invention but do not limit it in any way.
[0066] A mixture of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione (8.0 g) and tetrahydrofuran (160 ml) was stirred and heated to 50° C. A solution of meso-tartaric acid (3.84 g) in water (20 ml) was added and the mixture stirred at 50° C. for 15 minutes, filtered and the clear filtrate cooled to 21° C. The solvent was evaporated under reduced pressure at 40° C., acetone (40 ml) was added and the mixture stirred at 21° C. to give a white suspension. The product was collected by filtration, washed with acetone and dried under vacuum to give 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione meso-tartrate (10.6 g) as a white, crystalline solid.
[0067] A mixture of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl] thiazolidine-2,4-dione (3.0 g, 8.4 mmol), acetone (40 ml) and tetrahydrofuran (5 ml) was heated at reflux for 2.5 hours with stirring. To this was added a solution of meso-tartaric acid monohydrate (1.41 g, 8.4 mmol) in water (2 ml). The reaction mixture was heated at reflux with stirring for 2.5 hours, then cooled to 21° C. and stirred for 16 hours at 21° C. The white solid was collected by filtration, washed with acetone (40 ml) then dried under reduced pressure for 2.5 hours at 21° C. to afford 5-[4-[2-N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione meso-tartrate (3.25 g) as a white crystalline solid.
[0068] A mixture of 5-[4-[2-N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl] thiazolidine-2,4-dione (10.0 g, 28 mmol), acetone (120 ml) and tetrahydrofuran (15 ml) was heated at reflux for 50 minutes with stirring. To this was added a solution of meso-tartaric acid monohydrate (4.7 g, 28 mmol) in water (6.0 ml). The reaction mixture was heated at reflux with stirring for 1 hour, then cooled to 21° C. and stirred for 16 hours at 21° C. The white solid was collected by filtration, washed with acetone (50 ml) then dried under reduced pressure for 3 hours at 21° C. to afford 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione meso-tartrate (11.7 g) as a white crystalline solid.
[0069] Characterising Data Recorded for the Product of Example 1
[0070] The infrared absorption spectrum of a mineral oil dispersion of the product was obtained using a Nicolet 710 FT-IR spectrometer at 2 cm−1 resolution (FIG. 1). Data were digitised at 1 cm−1 intervals. Bands were observed at: 3405, 1738, 1694; 1629; 1556, 1537, 1505, 1459, 1436, 1418, 1330, 1268, 1249, 1223, 1182, 1167, 1143, 1104, 1074, 1057, 1033, 1000, 949, 916, 887, 853, 818, 771, 717, 668, 619, 568, 528, 515 cm−1.
[0071] The infrared spectrum of the solid product was recorded using Perlin-Elmer Spectrum One FT-IR spectrometer fitted with a universal ATR accessory. Bands were observed at: 3407, 2937, 2750, 1739, 1693, 1628, 1555, 1535, 1504, 1476, 1459, 1412, 1388, 1358, 1330, 1261, 1248, 1222, 1182, 1167, 1143, 1101, 1074, 1056, 1033, 999, 948, 916, 887, 853, 818, 771, 744, 717, 667 cm−1.
[0072] The Raman spectrum of the product (FIG. 2) was recorded with the sample in an NMR tube using a Nicolet 960 E.S.P. FT-Raman spectrometer, at 4 cm−1 resolution with excitation from a Nd:V04 laser (1064 nm) with a power output of 400 mW. Bands were obserbed at: 3101, 3059, 2952, 2922, 2877, 1739, 1604, 1544, 1458, 1438, 1394, 1331, 1270, 1222, 1203, 979, 887, 827, 739, 668, 638, 605, 472, 344 cm−1
[0073] The X-Ray Powder Diffractogram pattern of the product (FIG. 3) was recorded using the following acquisition conditions: Tube anode: Cu, Generator tension: 40 kV, Generator current: 40 mA, Start angle: 2.0° 2θ, End angle: 35.0° 2θ, Step size: 0.02° 2θ, Time per step: 2.5 seconds. Characteristic XRPD angles and relative intensities are recorded in Table 1.
TABLE 1 Angle Rel. Intensity 2-Theta° % 4.9 11.4 9.3 12.4 9.9 3.1 12.2 1.9 14.3 3.3 14.9 7 15.2 19 15.9 23.8 16.2 13.9 17.0 8.6 17.3 17.5 18.1 25.9 18.5 31.3 19.1 10.7 19.9 18.4 20.4 100 21.6 26 22.2 23.7 22.7 6.1 23.6 23.1 24.5 5.7 25.2 23 25.8 9.2 26.2 17.8 26.8 11.5 27.4 14.7 28.1 6.8 28.4 8.7 29.7 5.7 30.2 9.7 30.6 9.3 31.1 23.6 31.4 13.4 32.2 14 32.6 19.7 32.9 15.2 33.6 11.4 33.8 12.4 34.4 8.7 34.7 9
[0074] The solid-state NMR spectrum of the product (FIG. 4) was recorded on a Bruker AMX360 instrument operating at 90.55 MHz: The solid was packed into a 4 mm zirconia MAS rotor fitted with a Kel-F cap and rotor spun at ca. 10 kHz. The 13C MAS spectrum was acquired by cross-polarisation from Hartiann-Hahn matched protons (CP contact time 3 ms, repetition time 15 s) and protons were decoupled during acquisition using a two-pulse phase modulated (TPPM) composite sequence. Chemical shifts were externally referenced to the carboxylate signal of glycine at 176.4 ppm relative to TMS and were observed at: 183.0, 177.2, 175.4, 173.0, 160.0, 159.0, 151.8, 144.2, 139.9, 134.3, 130.8, 128.2, 123.6, 113.7, 112.8, 77.4, 76.7, 74.5, 55.5, 53.5, 50.0, 42.4, 36.6, 33.8 ppm.
[0075] Properties of the Meso-Tartrate
[0076] Solid State Stability of the Meso-Tartrate, recorded for the product of Example 1 The solid state stability of the drug substance was determined by storing approximately 1.0 g of the material in a glass bottle at i) 40° C./75% Relative Humidity (RH), open exposure, for 1 month and b) at 50° C., closed, for 1 month. The material was assayed by HPLC for final content and degradation products in both cases.
[0077] a) 40° C./75% RH: No significant degradation observed (HPLC assay 97% initial).
[0078] b) 50° C.: No significant degradation observed (HPLC assay 98% initial).
[0079] Melting Point of the Meso-Tartrate
[0080] The melting point of the Meso-Tartrate was determined according to the method described in the U.S. Pharmacopoeia, USP 23, 1995, <741> "Melting range or temperature, Procedure for Class Ia", using a Buchi 545 melting point instrument.
[0081] Product of example 1, Melting Point: 149° C.
[0082] Product of example 2, Melting Point: 153° C.
[0083] Product of example 3, Melting Point: 155° C.
[0084] Tonset of the Meso-Tartrate
[0085] The Tonset of the drug substance was determined by Differential Scanning Calorimetry using a Perkin-Elmer DSC apparatus.
[0086] Product of example 1, Tonset (10° C./minute, closed pan): 146° C. Product of example 2,
[0087] Tonset (10° C./minute, open pan): 153° C.
[0088] Product of example 3, Tonset (10° C./minute, open pan): 154° C.
|Patente citante
|Fecha de presentación
|Fecha de publicación
|9 May 2006
|14 Oct 2008
|Teva Pharmaceutical Industries, Ltd.
|2-N{5-[[4-[2-(methyl-2-pyridinylamino) ethoxy] phenyl]methyl]-2,4-thiazolidinedione} butanedioic acid, methods of preparation and compositions with rosiglitazone maleate
|20 Oct 2006
|15 Dic 2009
|Teva Pharmaceutical Industries, Ltd.
|2-N{5-[[4-[2-(methyl-2-pyridinylamino) ethoxy] phenyl]methyl]-2,4-thiazolidinedione} butanedioic acid, methods of preparation and compositions with rosiglitazone maleate
|Clasificación de EE.UU.
|514/342, 546/269.7
|Clasificación internacional
|Clasificación cooperativa
|Clasificación europea
|21 Jul 2003
Owner name: SMITHKLINE BEECHAM P.L.C., UNITED KINGDOM
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:CRAIG, ANDREW SIMON;HO, TIM CHIEN TING;MILLAN, MICHAEL JOHN;REEL/FRAME:013812/0144
Effective date: 20030128


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text: We only had a main dish, and they were very nice: the veal steak and the mullet. Both dishes very rich in flavor, cooked to perfection and with nice veggies. Very friendly staff but they could be bit more attentative, that would have prevented that it took 90 minutes for the dishes to be served.


text:
HOUSTON (AP) -- Tracy McGrady shouldered the burden of doing it
all in Orlando, and had no playoff success to show for it.
With a little more help in Houston, McGrady is on the brink of a
postseason breakthrough.
Playing with the desperation of a man on the brink of
elimination, McGrady had 37 points, eight rebounds and seven
assists to help the Rockets avoid a first-round exit with a 101-83
victory over Dallas on Thursday night.
"He's our superstar and we ride him," Rockets guard Mike James
said. "Tonight we tried to help him with the load. We know he's
going to lead us, we've just got to chip in."
The series is now tied 3-3, with Game 7 in Dallas on Saturday.
The winner will face top-seeded Phoenix in the Western Conference
James came off the bench for 22 points, Jon Barry scored 12 of
his 14 points in the fourth quarter and Dikembe Mutombo provided
some stout interior defense for the Rockets, who have been bounced
in the opening round in their last three playoff appearances.
Houston last won a series in 1997, when the lineup featured Hakeem
Olajuwon, Clyde Drexler and Charles Barkley.
Jerry Stackhouse led Dallas with 21 points, and Dirk Nowitzki
scored 19 on only 5-of-22 shooting as he continued his series-long
struggles against McGrady's defense.
Rockets fans who were disappointed by blown fourth-quarter leads
in the last two home games, including a 20-0 run by Dallas in Game
3, were treated to an improbably dominant finish in this one.
McGrady scored eight straight points, including two 3s, during a
19-0 spurt that turned a close game into a rout and gave Houston a
101-80 lead. Dallas could not stop McGrady with double teams, rough
play or simply allowing him to fire away from outside.
"When I feel like I can make 3s from anywhere on the floor,"
said McGrady, who went 6-of-10 from behind the arc, "my defender
is at my mercy."
The Mavericks couldn't even counter with their highly touted
offense. Dallas shot 4-for-27 in the final period, watching shot
after shot bounce off the rim as the Rockets pulled away down the
McGrady, who has never advanced past the first round in his
eight-year career, came through in the clutch to avoid having his
team blow a two-game lead for the second straight time. It also
happened when he played for Orlando against Detroit in 2003.
"I've been in this situation before," McGrady said. "I'm
going to lay everything out on the line -- leave everything out
there on that basketball court, and I'm going to bring my teammates
with me."
Back in Orlando, of course, he never had this kind of help: an
All-Star big man in Yao Ming, a bench teeming with driven veterans,
and a coach who once led an eighth-seeded team to the NBA Finals.
After drawing a $100,000 fine -- the largest ever assessed
against a coach -- for accusing officials of targeting Yao this
postseason, Rockets coach Jeff Van Gundy was greeted by loud cheers
during pregame introductions.
That didn't stop Van Gundy from giving officials a mouthful
after a hard foul on Yao midway through the second quarter that
sent the 7-foot-6 center tumbling to the floor. Yao scrambled to
his feet and stared down at Dallas' Josh Howard -- a rare show of
anger from the gentle giant -- but was quickly escorted away by
That foul seemed to wake up the Rockets, who soon took their
first lead of the game on a three-point play by Ryan Bowen.
The Mavericks responded with their own complaints about the
officiating after this one, including rookie coach Avery Johnson,
who clearly didn't appreciate all the attention focused on Van
Gundy's remarks.
"Maybe I need to go crazy. Maybe I should go crazy. Maybe that
will help," Johnson said in a rambling postgame tirade. "This
series is about basketball, not all the other stuff. We lost the
game. We don't make excuses. The game was called fairly pretty much
... there's no excuses, no complaints, no nothing."
Stackhouse even made a suggestion that will almost certainly
catch the attention of NBA commissioner David Stern.
"It was like there were phantoms out there fouling,"
Stackhouse said. "Normally you know who fouls. But tonight we were
looking around trying to figure out who they called it on. Maybe
everyone wanted to see a Game 7."
McGrady came up with a scoring flurry just before halftime. He
hit a 29-footer on one possession and nailed another 3 as he was
fouled by Michael Finley. McGrady mugged for the crowd, then
completed the four-point play to give Houston a 10-point lead.
He even took on the task of slowing down Stackhouse, who made
his first six shots, including two 3s, to push the Mavericks out to
an 11-point lead early in the second quarter.
But with McGrady shadowing him, Stackhouse made only three of
his next 10 attempts. James scored 13 points in the second quarter
to provide the Rockets with their own spark off the bench, and
Houston was back in the game.
The Rockets won without much help from Yao, who avoided foul
trouble for the first time in the series but never seemed to find a
rhythm. Yao finished with just eight points and five rebounds and
sat out the entire fourth quarter as Van Gundy went with Mutombo.
"I had a good night's sleep last night, and when I came here, I
just felt we were going to win," said Mutombo, who had 10 rebounds
and four blocks. "I'm not ready to go home."
Game notes
Finley became the Mavericks' career leader in postseason
games played with 49, surpassing Rolando Blackman and Derek Harper.
... Game 6 was the first time the team that outscored its opponent
in the first quarter lost. ... Houston has an all-time record of
5-1 in Game 7s.


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Guest Post by Paul Ziegler
Thursday, 20 February 2014 by TOSBlog
What Happened to Our Math? Math in the United States has been, and continues to be, on the decline. It seems as though our students are getting dumber, when in fact, they are just part of the "great dumbing down" started many years ago. The students are not the problem. The curriculum they are using
- Published in Blog, Guest Writer
Tagged under: math, Paul Ziegler, systemath, Systematic Mathematics
School season is here! Important notice from SchoolhouseTeachers.com:We just released FIVE new classes, bringing our...Posted by The Old Schoolhouse Magazine on Monday, August 31, 2015


text:
Dr. Bronner's Liquid Soap - All Scents
210 reviews
89% would repurchase
Package Quality: 3.9
Price: $$
Package Quality: 3.9
Price: $$
Not tested on animals
on 4/26/2015 10:32:00 PM
Age: 44-55
Skin: Oily, Olive, Warm
Hair: Black, Curly, Coarse
Eyes: Green
I never thought to write a review on this stuff...it's been so much a part of my life, for as long as I can remember, that it fades into scenery. Over the years I have used all the scents but the ones I buy continually are Peppermint and Almond. (Note: be careful with the Peppermint one in "sensitive" areas of the body...) Summer in Arizona can be HOT, and the Peppermint soap literally cools the temperature of our skin. It feels wonderful. I never use anything with "lather", and I've never tried to make this liquid soap foam. I apply it on a shower pouf and wash. I was surprised to read reviews that talk about its lather. I guess living most of my life with Los Angeles water kept me unaware of the joy of soap bubbles, because I never knew this stuff to lather! (I don't think I'd like it if it did...I don't like a "soapy" feel). The Rose smells lovely, but it's just too strong for my nose. It seems like everbody I know uses these soaps, or has at least tried them, and I don't know of anyone who hasn't been intrigued by the quirky, hippie "preachings" on the bottles. It's impossible not to be drawn into reading them in the shower. What better to do in the shower than read about uniting humanity on "Spaceship Earth"? I like this soap for hand soap, body cleanser, laundry detergent, household cleaning, and makeup brush cleaner, but I can't use it in my hair...I tried it once...and I still get shivers thinking about it. My skin loves olive oil, so it's not surprising castile soap leaves it in clean, soft condition. I put the castile soap in my own pump hand-soap bottles as well. A little goes a long way, and they keep my family and our environment clean.
on 4/20/2015 11:48:00 PM
Age: 25-29
Skin: Acne-prone, Fair-Medium, Not Sure
Hair: Blond, Other, Other
Eyes: Green
Dr. Bronners has been a staple in my family for as long as I can remember. We used to houseboat in the summer on Lake Shasta, and would take "showers" by scrubbing down with this stuff and then jumping in the lake :) the peppermint liquid soap smell is so nostalgic for me - there is nothing like the cool, tingly feeling on a hot summer night! I have also tried (and loved) the lavender. I will try the almond and rose scents next, as I have heard great things! I have yet to try any of the bar soaps so this review is solely for the liquid soaps.
As a body wash, this definitely gives you that "squeaky clean" feeling. Be careful not to use too much - read the directions (if you can find them amidst the crazy hilariously awesome religious rant on the bottle) or Lisa Bronner also has a blog that is really helpful with dilution ratios. Basically I wouldn't recommend using this stuff straight - put a few drops on a loofah and rinse with water before scrubbing, or dilute beforehand like a 1:3 ratio and then use it. It is a big drying (I have already dry skin, though) but just follow up with a moisturizer or body oil after your shower and you're good to go. Remember, it is still a SOAP, but the benefits of not using any parabens or toxic chemicals on your body is well worth it!
As a shampoo, it is definitely not my favorite but will work in a pinch or when camping. You definitely want to use a conditioner after, or else your hair will feel like straw. But again, it does give you the sqeaky clean feeling that some people like. I have not tried diluting it and using it as a shampoo, so that could change the results.
As a makeup brush cleaner, this is my absolute HG. I use a blend of oils as a facial moisturizer morning and night (grapeseed oil plus some essential oils) and then use foundation over it in the mornings, so my makeup brushes are always pretty gnarly within a week. This will clear out any gunk in SECONDS and gives them a nice clean scent. My brushes are like brand new every time :)
I have not yet used this as a facewash, as I have finally recently cleared up my skin and I'm afraid to change anything in my routine with the fear of breaking out! But i'm sure eventually I will cave, and I will update my results :)
As many other reviewers have said, you can also make an all-purpose house cleaner by diluting the liquid soap of your choice, but I haven't gotten around to do that, either. Just a matter of time before i try!
This stuff is a GREAT, INEXPENSIVE, MULTI-PURPOSE all in one magical product. It's not for everyone, but if you figure out how to use it correctly and DILUTE, it could totally simplify and detoxify your life!!
Edit: I bumped this down a lippie because after prolonged use of the peppermint liquid soap body wash, my skin got pretty dried out. I look forward to trying to almond to see if that makes a difference :)
on 4/19/2015 4:33:00 PM
Age: 30-35
Skin: Very Dry, Medium, Not Sure
Hair: Black, Other, Other
Eyes: Brown
I always got the liquid soap in Lavender.However, after moving to a location with hard water, this soap does NOT lather well in hard water at all. In my previous home, we had a heavy duty softener and the lathered great on a wash cloth with lots of suds. But in a harder water region (like Arizona) you have to use double the amount and it still doesn't create the later you need. The bar however does fine, but I find it more drying. So until we move to a location with softer water, I've switched to Kirk's Castile Bar Soap for now.
on 4/19/2015 1:55:00 PM
Age: 56 & Over
Skin: Dry, Fair-Medium, Warm
Hair: Red, Curly, Medium
Eyes: Brown
I like to clean my makeup sponges frequently. This liquid soap cleans them better than a liquid detergent.
on 4/16/2015 7:59:00 AM
Age: 25-29
Skin: Very Dry, Fair, Neutral
Hair: Red, Straight, Medium
Eyes: Blue
Holy Grail product for.... everything.
I'm a big ol' hippie who loves to use this for cleaning around the house. Hand dishwashing liquid, making laundry soap, cleaning the counters, the floors, the tubs, literally everything!
In the shower, this has become my all-in-one product. Body wash (doubles as shaving lather with GREAT glide), face wash, no-poo shampoo (dilute it, please!!). I decant some from the big bottle into a small airplane travel bottle and a little goes a long way, so the 3 ounces in there probably last me 3 weeks with all of those uses. I have less products in the shower than my husband does now!
Cleans makeup brushes better than anything I have ever tried.
As others reviewers have said, it may be a bit drying for those with dry skin. I have SUPER dry skin, but I am diluting it so the dryness goes down there, but I moisturize like crazy immediately after getting out of the shower regardless of what soap I am using, so it doesn't bother me.
Currently I use the peppermint scent, but mostly because I can find it at Costco in the HUGE bottles for way less than I buy it at the grocery store, and the price difference is crazy. But they only sell the peppermint scent currently, to my knowledge.
The bottle is covered in crazy cult made up religion talk, but if you can get past the gibberish there is actually useful information somewhere. Listen to the bottle and DILUTE. Read more stuff online on "recipes" to make all the stuff I mentioned, and you won't be disappointed!
on 11/7/2014 7:32:00 AM
Age: 36-43
Skin: Acne-prone, Dark, Not Sure
Hair: Black, Other, Other
Eyes: Brown
I have tried the peppermint, lemon and rose versions, mainly as a body wash.
All in all, I really like them and their versatility. Also great value if you dilute them 3-1. I just wish that amid all the crazy text on the label, they would highlight the directions of use. If I could purchase them easily where I live, I would use them for everything. My boyfriend is hard to please but even he likes them although the rose is too feminine for him and the peppermint too strong in terms of fragrance. He prefers the lemon. I like them all and would love to try the other iterations such as baby.
They are a bit drying and I would not use them on my face and hair except in an emergency. The peppermint does feel quite refreshing and tingly on my scalp though. Also try cleaning your ears with the peppermint - most cooling!
on 7/29/2014 9:30:00 PM
Age: 36-43
Skin: Oily, Fair-Medium, Neutral
Hair: Brunette, Wavy, Coarse
Eyes: Brown
Castile soap is such a versatile product! I use the peppermint version as a refreshing shower gel in the summer. I use the unscented version to make DIY shampoo, face wash, laundry detergent, and makeup brush cleanser. I really want to try making my own shower gel, too. It can be a bit tough on hair, so you must add some moisturizing ingredient like glycerine or jojoba oil. It is a bit pricey and the dispenser's hole is fairly large since the product is such a thin consistency. However, I like that it's a much more natural product and the packaging is really cute. I always have some of this on hand.
on 7/21/2014 12:41:00 PM
Age: 19-24
Skin: Combination, Tan, Not Sure
Hair: Black, Straight, Medium
Eyes: Brown
I love this to clean my make up brushes. HG.
Update: 05/05/2015. I don't know if they changed the formula recently, but I feel as though this bottle isn't getting my brushes as clean as it should. I now have to go back, and re-wash my brushes, and even then, the lather doesn't remove all of the makeup. My brushes get washed after their second/third use- so they don't build up with product....but for some reason, this just isn't working for me anymore. I use a brush glove to clean, so no, it's not a user error. :(
Update: 05/11/2015. Okay, so I am back on the bandwagon with this soap. I like it again. I wash my brushes a bit differently now, I no longer use a glove- but I use a plastic round container, and lather up my brushes like that, and same with washing the soap out. I use the container, fill it up with water- and rub my brush on the bottom of the container. This works way better, and it doesn't damage my brushes and their shapes. Highly recc this soap, but try to see what method in terms of lathering up the soap works for you. :)
Update: 05/15/2015. So I find that this soap doesn't lather up in water too well. Meaning, I have to use a little water- and soap, to get a good lather. If I use too much water, or the brush is wet; the soap will not lather up. I want to like this brush cleaner so badly, because it's the standard; and it's anti-bacterial. But finding a way to lather it up is difficult. I don't know how people mix this with water, and then use it. I have to use the soap raw; with a little water. That works for me.
Update: 05/23/2015. Go out and buy this. I lather up my brushes using a plastic container, and it works so much better. I use a few drops of soap, and then rub the brush against the bottom to lather it up. Then I wash it the same way using a container filled with a little water. HG product of mine, and I love washing my brushes when I'm using this because I know that they are clean.
Update: 05/30/2015. I took a hot glue gun, and made some dots on the bottom of my container to help lather it up, this works 100 times better. Just be careful not to rub the brushes too hard. I love this soap. *Cue angel singing*.
on 7/7/2014 1:30:00 PM
Age: 30-35
Skin: Very Dry, Fair, Not Sure
Hair: Brunette, Wavy, Fine
Eyes: Brown
LOVE this product!
My skin is so sensitive, and I'm always reacting to products. Unfortunately, I have no idea what ingredients I react to, so it's always a guessing game. Dr. Bronner's has become my go-to body wash. All of my eczema and redness has cleared up.
I use the almond or the unscented; for some reason, I seem to react to the lavender. I keep an old bottle, and dilute the new stuff with 30% soap, 70% water and it still lathers and cleans beautifully - its lasts for.ever!
Note to other users: diluted with hot water, Dr. Bronners is also excellent as a hardwood floor cleaner or a multi-purpose household cleaner!
on 6/30/2014 1:26:00 PM
Age: 19-24
Skin: Acne-prone, Fair, Warm
Hair: Blond, Wavy, Medium
Eyes: Blue
Only been the baby mild liquid using on my face a few days but my acne seems less aggravated and flatter :) A little goes a long way. Don't scrub.
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Defending Nelson champ Dufner keeps even keel
Published May 15, 2013 3:44 pm
This is an archived article that was published on sltrib.com in 2013, and information in the article may be outdated. It is provided only for personal research purposes and may not be reprinted.
Irving, Texas • Jason Dufner says he has played a lot of rounds this year with frustration and anger on his mind.
He just rarely shows those emotions, the same as when things were going so well last season.
Dufner's win at the Byron Nelson Championship, which wasn't punctuated with any overwhelming outburst of excitement, was part of a four-week stretch in which he got his first two PGA Tour victories and got married. He followed that with a runner-up finish at Colonial and a fourth-place finish at the U.S. Open.
Going into Thursday's first round of this year's Nelson, Dufner hasn't had a top-10 finish this season.
The only players who have won consecutive Nelsons are Tom Watson, Jack Nicklaus and Sam Snead.
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text: previous next Fullscreen Art • October, 25 2010 • By David Fischer Banksy "Exit Through The Gift Shop" – Jamie D'Cruz and Chris King Interview Shares Share Tweet Email Reddit Flipboard WhatsApp Comments Movie City News sits down with the producer and the editor of Banksy's "Exit Through The Gift Shop" film, Jamie D'Cruz and Chris King. The movie leaves many open questions, of which some might be answered in this lengthy interview. Via MCN/Hypebeast. Enjoy! Filed under: Art, banksy, interviews, videos


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Tinder is making headlines once again, and this time it's over a campaign by the AIDS Healthcare Foundation, which has put up several billboards and bus bench ads in Los Angeles, according to The Star.Read Full Story
Remember that color-changing dress that drove the Internet mad a few months ago, with people clearly seeing it as either blue and black or white and gold? Well, here's the latest photo that has people pondering just what they're really seeing.Read Full Story
The second GOP primary debate of the 2016 election season held far more promise than the first. While still dominated by the larger-than-life persona that is The Trump, we were also able to hear from the other candidates — some who actually give hope to this conservative that all is not lost.Read Full Story
As a Republican, the 2016 election season officially began for me with last night's presidential debates. I set my DVR, got the kiddos off to bed and settled in with popcorn and a notepad, ready to wade through the three hours of scripted talking points the 17 major candidates had planned. By the end of the night there were two clear winners: The Donald and Carly Fiorina. My party is doomed.Read Full Story
A morning radio show host at a Colorado station raised the ire of just about everyone when he compared breastfeeding to incest, but then he admitted that it was a disgusting statement and that he was a jerk for saying so in the first place.Read Full Story
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Buy properties in Sedberg Street, Fulwood, Preston PR2
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Sedberg Street, Fulwood, Preston, Lancashire PR2End terrace house for sale - 3 bedrooms
The interior of this Victorian end of terraced house is oozing with character and charm and has some unique and quirky features. (contd...) More details
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- Preston (Lancs) (1.2 miles)
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Marketed by Bridgfords - Fulwood, PR2. Call 01772 368063


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Gippsland clubs call for regional AFL salary cap
The AFL's Gippsland body said escalating player payments have forced country leagues to look at introducing a salary cap system.
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AFL Gippsland general manager, Travis Switzer, said clubs are finding it harder to meet the financial demands of marquee players.
"It's really important that clubs compete on the field, as you know, it has a real impact on the club's culture and the club's activities if they're non-competitive," Mr Switzer said.
In March, AFL Victoria began looking into salary cap or point systems in leagues across the state.
Mr Switzer said the problem was probably not as bad in Gippsland as other regions, but a player points system would still be investigated.
"Clubs get capped on the number of points that they can have in their club in terms of players and their experience, whether they're an ex-AFL or VFL player," he said.
"The sport is really crying out for something and it's either salary caps or points systems and we've got to try and come up with a system that works for clubs down here."
Mr Switzer said feedback from clubs suggested that a salary cap might be hard to police, but a system would be trialled in 2015 and consolidated in 2016.
He said expensive payments to star players for one-off games, such as Brendan Fevola who kicked 15 goals for Lindenow in June, paid off for some clubs but not others.
The results of a statewide survey of clubs on the issue will be presented to regional AFL bodies for further consideration.
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I know that this video was supposed to be a joke and on some level it might be if the soliders weren't from a country which has so many problems. I'm trying really hard to remeber why I defend Israel to all my friends and family but I can't rember any of the reasons. Yes maybe people should lighten up however how can we when the situation between Israelis and Palestiens is so tense and controversial?? And yes I did think it was funny but it does undermind the seriousness of complex problems the surrounds Israel.
Palestinian teen arrested for allegedly rioting in East Jerusalem (Haaretz)
from the article: IDF soldiers face penalty after uploading Hebron dance video to YouTube


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Do you know what happened the day after Jan. 19, 1980? But the Libtards claimed that Bush-41 flew to Paris in an SR-71 in Oct. 1980 to make a deal with Iran?!?<quoted text>
I have a buddy he was at Lakenheath in the early 80's and one of his jobs was to transmit the go code to launch the F1-11's to the eastern block countries.
Of course the U.S stored nuclear weapons there.
We all remember when Iran hostage crisis and the story that we paid the govermnent to free then. Well right before they were free a top secert cargo plane stoped at Lakenheath the only thing known about the shipment was it's weight
So my friend said they his friend look that days paper for that days gold price and he did a little math and the weight for that cargo was right on if it was gold.
Algiers Accords
From Wikipedia, the free encyclopedia
The Algiers Accords of January 19, 1981, was brokered by the Algerian government between the United States and Iran to resolve the Iran hostage crisis.[1] The crisis arose from the takeover of the American embassy in Tehran on November 4, 1979, and the taking hostage of the American staff there. By this accord the 52 American citizens were set free and able to leave Iran.
Among its chief provisions are:[2]
The US would not intervene politically or militarily in Iranian internal affairs
The US would remove a freeze on Iranian assets and trade sanctions on Iran
Both countries would end litigation between their respective governments and citizens referring them to international arbitration, namely the IranUnited States Claims Tribunal.
The US would ensure that US court decisions regarding the transfer of any property of the former Shah would be independent from "sovereign immunity principles" and would be enforced
Iranian debts to US institutions would be paid
The US chief negotiator was Deputy Secretary of State Warren Christopher,


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June 25, 2011
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i like to fuck that girl!
Gatinha gostosa demais... Bucetinha cor-de-rosa. hummm....
Omg he is so hot i want him to fuck me sooo hard
good video


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Golden Turmeric Latkes with Applesauce
From EatingWell: November/December 2010
These crispy-on-the-outside-and-tender-on-the-inside latkes are delicious paired with a subtly spicy clove-scented applesauce.
Makes: 6 servings, 2 latkes each
Active Time:
Total Time:
Nutrition Profile
Low calorie | High fiber | Low saturated fat | Low sodium | Heart healthy | Healthy weight | Diabetes appropriate | Gluten free |View Our Nutrition Guidelines »
- 1 tablespoon canola oil
- 2 teaspoons grated fresh ginger
- 1/2 teaspoon ground turmeric
- 1/2 teaspoon ground cloves
- 1 cup unsweetened applesauce
- 2 cups shredded peeled russet potatoes
- 1 small onion, finely chopped
- 1-2 fresh green serrano chiles, stemmed and finely chopped
- 3 tablespoons finely chopped fresh cilantro leaves and tender stems
- 1/2 cup chickpea flour (see Note) or unbleached all-purpose flour
- 1 teaspoon ground cumin
- 1 teaspoon kosher or sea salt
- 1/2 teaspoon ground turmeric
- 2 large eggs, slightly beaten
- 2 tablespoons canola oil, divided
- To prepare sauce: Heat 1 tablespoon oil in a small skillet over medium-high heat. Add ginger and cook, stirring, until light brown and aromatic, 30 seconds to 1 minute. Stir in turmeric and cloves. Cook until the spices are fragrant, 30 seconds to 1 minute more. Scrape the spices into the applesauce in a small bowl and stir well to combine.
- Preheat oven to 200°F. Place a baking sheet in the oven.
- To prepare latkes: Thoroughly mix potatoes, onion, chiles to taste, cilantro, flour, cumin, salt, turmeric and eggs in a large bowl.
- Heat 1 tablespoon oil in a large nonstick skillet or griddle over medium heat. Place a heaping tablespoon of the potato mixture in the skillet and flatten with a spatula into a disk roughly 3 inches in diameter. Form as many latkes as you can in the pan without overcrowding. Cook until golden brown and crispy on the bottom, 3 to 5 minutes. Flip and continue cooking until the other side is golden brown and crispy, 3 to 5 minutes. Briefly drain on a paper towel-lined plate, then transfer to the oven to keep warm. Repeat with the remaining oil and potato mixture.
- Serve the latkes with the seasoned applesauce.
Tips & Notes
- Make Ahead Tip: Cover and refrigerate the sauce (Step 1) for up to 3 days.
- Note: Chickpea flour, or garbanzo bean flour, is commonly used in Indian and Middle Eastern cooking. It's a gluten-free alternative to wheat flour. Look for it in the gluten-free or bulk-foods section of large supermarkets and natural-foods stores or online at bobsredmill.com.
Per serving: 187 calories; 9 g fat (1 g sat, 5 g mono); 71 mg cholesterol; 22 g carbohydrates; 0 g added sugars; 5 g protein; 3 g fiber; 221 mg sodium; 327 mg potassium.
Carbohydrate Servings: 1 1/2
Exchanges: 1 starch, 1/2 fruit, 1 1/2 fat
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Recipe Categories
- Type of Dish
- Side dish, potato/starch
- Ease of Preparation
- Moderate
- Total Time
- 45 minutes or less
- Servings
- 6
- Health & Diet Considerations
- Diabetes appropriate
- Low calorie
- Low saturated fat
- Low sodium
- Heart healthy
- Healthy weight
- High fiber
- Gluten free
- Preparation/ Technique
- Saute
- Meal/Course
- Dinner
- Holiday
- Hanukkah
- Publication
- November/December 2010


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DETROIT A pharmacist-directed anticoagulation service improves the coordination of care from the hospital to an outpatient clinic for patients treated with the anticoagulant drug warfarin, according to a Henry Ford Hospital study.
The study, published online today in the July/August issue of the Journal of Hospital Medicine, found that the transition of care directed by the anticoagulation service was seamless in more than 70 percent of patients treated and risk of bleeding and thrombosis declined by nearly 5 percent compared to patients not treated by the anticoagulation service. The study is available at http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291553-5606
"Our pharmacist-directed anticoagulation service has shown to improve the quality of care for patients taking warfarin in the hospital and transitioning to an outpatient setting," says James Kalus, PharmD, senior clinical pharmacy manager at Henry Ford and senior author of the study.
"The advantage of this service is that it improved the patient transition, enhanced communication between inpatient and outpatient clinicians and ensured that patients made it to their outpatient follow-up appointment after being discharged from the hospital."
Warfarin, used to prevent clots from forming or growing larger in the blood or blood vessels, is prescribed for certain heart-related conditions. It is linked to an estimated 30 percent of anticoagulant-related medication errors.
Henry Ford sought to evaluate the impact of the anticoagulation service for managing the care and safety of patients receiving warfarin during hospitalization and after discharge to an outpatient anticoagulation clinic. Researchers followed 500 patients hospitalized in two Internal Medicine units and two cardiology units.
Researchers applied four key compliance metrics to measure h
|Contact: David Olejarz
Henry Ford Health System


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It's getting down to the nitty gritty in MLS with one calendar month left in the season. This weekend all 20 MLS teams are in action and that means it's a great chance to lock in your DraftKings team! Follow this link to sign up and use these tips below for picking your team this weekend.
FC Dallas picks -
Fabian Castillo - He's only tallied once in his last seven games and it's time for Fabian Castillo to break back out. The Colombian has a penchant for the big stage and this one with all eyes watching on national TV could be somewhat of a coming out party for the Colombian.
Victor Ulloa - The Homegrown player scored his first career MLS goal last weekend and as Sunday's game should open up on the offensive end, Ulloa is in great shape to at least pick up an assist on Sunday.
MLS picks -
Kei Kamara - The dude is just a straight up beast and about as reliable playing at home as it gets. He's almost sure to get on the scoresheet against Portland
Obafemi Martins - Seattle is the hottest team in MLS and against a Sporting KC team that will leak goals from time to time he's a great bet to find at least one and probably more goals.
Good luck!
Just eight games remain in the MLS regular season and only four more home games! FC Dallas hosts NYCFC on Saturday night presented by Raytheon as the club looks to move within a point of the top spot in MLS with a win. Here are the ten things to know before you head to Toyota Stadium.
1. Saturday's match is presented by Raytheon and they're teaming up with DFW USO for Military Appreciation Night. Be sure to stop by their area in the northwest concourse to show your appreciation to our troops!
2. Join us on Saturday morning before the match as Team BR19 will be walking together in the Dallas Heart Walk. Both head coaches Oscar Pareja and Jason Kreis are planned to join us and at the game on Saturday night Bevan Rhine, wife of Bobby, will be our honorary Lamar Hunt Statue scarfer at 7:00PM so be sure to join us for that!
3. Throughout the month, MLS is making note of Childhood Cancer Awareness Month and we want to let you know about a member of our FC Dallas Family who is fighting. Ellie Slate of the FC Dallas '04 Girls Premier team is staying incredibly brave in her fight against Leukemia and 50 special limited edition scarves will be on sale in the team store on Saturday with all proceeds benefitting her Gofundme account. See how you can help here.
4. Our official match poster created by Olivia Brestal is one you definitely need to snag! Get yours for a few bucks in the team store on Saturday night.
5. Did you know the FC Dallas and NYCFC rosters represent 18 different countries from four continents? Check out more great numbers like that one in our by the numbers feature.
6. This is the only home matchday in September and your best chance to snag our September Scarf of the Month dedicated to the great Bobby Rhine. A portion of the proceeds go to the American Heart Association.
7. It's actually going to feel like fall outside at Toyota Stadium on Saturday night! Temperatures are expected to be in the upper 70s and pretty much perfect. You might even want to bring a light jacket. Seriously.
8. How will the FC Dallas defense deal with NYC's three UEFA Champions League winners and how has the move to a 4-4-2 benefitted FCD? We talk about it in the Keys to the Match driven by Toyota.
9. It's a bit of a unique TV situation on Saturday night as our match will be shown live on Time Warner Cable Sports channel 323 with Bob Sturm and Steve Jolley on the call while the match will also be shown on tape delay on TXA 21 directly following the Texas Rangers game. Don't forget you can also listen live in the stadium on 100.7FM in English and 1270AM in Spanish. Don't forget to tune into the post-game show on the way home!
10. Some tickets are still available for #FCDvNYC and you can get those here! Just four home games remain as we make our playoff push.
For 28 days of August, the hottest month of the year was incredibly unkind to FC Dallas who had amassed no points from three matches against Chicago, Los Angeles and Vancouver despite playing well enough to earn at least a point in two of them. Perhaps the soccer gods were saving all the good luck for the last weekend of the month.
Week 26 of the MLS regular season was one of the most positive for FCD as not only did Oscar Pareja's side secure a vital three points against a Western Conference rival nipping at their heels, but the Frisco side also saw results around the Western Conference go their way vaulting Dallas from fifth to third at the end of the weekend. It was a weekend that saw Dallas gain three points on each of the four teams above them in the standings entering the weekend.
Over in Colorado, the Rapids won their third game in a row coming from behind to beat Sporting Kansas City 2-1. The loss for SKC coupled with the Dallas win sees FCD leapfrog them in the standings now a point above their midwest foes with equal games played.
FCD also jumped above the Portland Timbers in the standings as they were unlucky to lose 2-1 at Seattle. The Timbers outshot and generally outplayed their opponents but fell in a match that sees FCD move to a point ahead of the Cascadia side while also holding two vital games in hand.
At the top of the West, both teams fell to defeat as Los Angeles dropped a 1-0 result away to San Jose while Vancouver lost 2-0 to Houston while losing two players to red cards. FCD sits four points behind Vancouver and five points behind LA at the top, but has two games in hand on the Whitecaps and three games in hand on LA.
Things simply could not be any tighter at the top of the Western Conference with .04 PPG separating Dallas, Los Angeles, Vancouver and Sporting KC. FCD is the only one of these four teams playing this weekend as Dallas travels to Columbus for a match on Sunday afternoon.
Have you ever wanted to get your very own FC Dallas game-worn jersey? How about one of the limited edition Fan Appreciation jerseys with the special numbers worn only in August of this season?
FC Dallas vs RSL is your chance with our FC Dallas Foundation Jersey Off Their Backs Auction. Here's how it works:
- Text fcdallas to 52182 and follow the promts to register. Then you will be directed to a website where you can bid on the auction for each player. You do not have to be present to be the winning bidder or place a bid.
- After entering your credit card info, place your bids. You will receive a text when you have been outbid.
- The auction ends at the end of halftime and winners will be notified early in the second half.
- If you are the lucky winner and at the game, go to the FC Dallas Foundation table on the northwest concourse at the 80th minute. You plus a guest will greet the player as he leaves the match to get your signed(and probably a little sweaty) jersey! If you are not at Toyota Stadium you will be contacted with details on how to receive your jersey.
All proceeds go to the FC Dallas Foundation so get to bidding tomorrow night and get a one-of-a-kind jersey from your favorite player!
Winners of four straight games, FC Dallas takes the Toyota Stadium field for the last time until August 15th on Saturday night when they host Western Conference rivals Portland Timbers FC. Sitting at the top of MLS, Saturday's match has huge playoff implications on the line so don't miss this one. Here are the 10 things to know about Saturday's match.
1. Be sure to arrive early as we are handing out the third in our collectible mini-scarf series. This one, presented by Chase, has the "Unite for 90" tagline and you want to get there early to grab one of those at the gate.
2. We're excited to be honoring our national champion U-15 and U-16s at halftime of Saturday's game. Be sure to stay in your seats for that one to give them the round of applause they deserve!
3. Our graphic designer Olivia Brestal has crafted up another awesome match poster for this weekend's game honoring 2015 MLS All-Star Fabian Castillo. Cop one in the team store on Saturday night and maybe Fabian will autograph it for you sometime.
4. Saturday's match is on TXA21 with the All-Star team of Mark Followill and Brian Dunseth on the call! If you can't catch the broadcast, tune to 100.7FM for the English call with Steve Davis or the legend Carlos Alvarado on 1270AM with the Spanish radio call.
5. Things have gotten very heated(no pun intented) between FC Dallas and Portland over the last couple of years. Check out some of the controversies bubbling under the surface as we head into this match.
6. One huge thing to watch on Saturday night is birthday boy Kellyn Acosta. The man who turns 20 on Friday scored his first MLS goal last week and the way he pushes into the attack makes FC Dallas an even more dynamic team. We talk about it in our Keys to the Match driven by Toyota.
7. Speaking of hot, our merch special for Saturday's match is an FC Dallas chill towel for just $5. That's a 50% off savings!
8. Saturday night is Season Ticket Holder kids' night at Toyota Stadium and in honor of that Houston Rogers of the Rogers' family will be the honorary Lamar Hunt Statue scarfer at 7:30PM on the north concourse!
9. Check out our #FCDvPOR match preview infograph to get all caught up on Saturday's match.
10. There's still time to get your tickets for tonight's match HERE or you can call 1.888.FCD.GOAL and they'll get you set up with the best remaining seat in the house!
Saturday's heart-stopping win over DC United means FC Dallas is back into a tie for first place at the top of the Major League Soccer standings and it also kept alive a few different streaks going into this Saturday's match vs Portland.
FCD has won four games in a row, which is the longest active streak in MLS and tied with Portland and Vancouver for the longest streak this season. Dallas can take over the longest streak in MLS this season with a win on Saturday. FC Dallas also carries the longest current unbeaten streak at five games in a row.
With his stoppage time goal, Fabian Castillo extended his consecutive games with a goal or assist streak to five in a row which is the longest active streak in MLS and tied for the second-longest this season with CJ Sapong. Only Clint Dempsey has a longer streak with eight.
Goalkeeper Dan Kennedy was finally beaten on Saturday, but not before setting the longest shutout streak in MLS this season at 349 minutes.
The FC Dallas win was their 10th of the season which is tied for the most in MLS and extended their league-best record when scoring first to an amazing 9-0-2.
Despite the ultra-tight Western Conference standings, FCD has solidified their playoff standing and now sit nine points ahead of Real Salt Lake above the dreaded red line.
FC Dallas is now tied with D.C. United at the top of the MLS Standings and alone in first at the top of the Western Conference standings.
- Saturday's match against Portland becomes all the more crucial for Dallas as it's one of 11 remaining games against Western Conference opponents. FCD could extend the gap over the Timbers to six points with a game in hand if they can beat Caleb Porter's side on Saturday night.
TICKETS: FC Dallas vs Portland Timbers - Saturday, July 25 8:00PM
It's nearly time for the huge July 4th match against New England. Carter and Daniel break down the game in Keys to the Match driven by Toyota
We've been trying to get this uploaded for ya'll for the last few home games and it's finally a go. In case you've never listened, FC Dallas has a fantastic radio broadcast with Steve Davis for every match and after home games we have about a 25 minute post-game show where Steve brings in a special guest to discuss everything we've seen.
This week, he brought in Tyler Kern the producer of the always-awesome ESPN Soccer Today presented by Toyota. Give it a listen and be sure to always catch the 100.7FM post-game show on your drive home from Toyota Stadium!
We've been trying to get this uploaded for ya'll for the last few home games and it's finally a go. In case you've never listened, FC Dallas has a fantastic radio broadcast with Steve Davis for every match and after home games we have about a 25 minute post-game show where Steve brings in a special guest to discuss everything we've seen.
This week, he brought in Tyler Kern the producer of the always-awesome ESPN Soccer Today presented by Toyota. Give it a listen and be sure to always catch the 100.7FM post-game show on your drive home from Toyota Stadium!
Here are your Keys to the Match driven by Toyota for Saturday's big game against the LA Galaxy:


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'Let's Get It On': Loose Lips Daily
As much local politics as humanly possible. Send your tips, releases, stories, events, etc. to firstname.lastname@example.com. And get LL Daily sent straight to your inbox every morning!
IN CASE YOU MISSED IT—"Joyner Family Wants Answers On Park Police Shooting," "FOIA Denials Under Fenty: The Charticle," "Is Someone Poisoning Dogs In Stanton Park?"
Good morning. Last night was an important one for local political junkies—it was the filing deadline for campaign finance reports! WBJ's Michael Neibauer noted that both main mayoral candidates raised some serious dough: "The two main players in the race for D.C. mayor waited until just before the midnight Thursday deadline to file their campaign finance reports, perhaps because they had so much money to count." Fenty Cash: "Mayor Adrian Fenty is sitting on a $3.2 million war chest going into the critical summer months, having raised $475,486 since March 11. He also spent $336,436 during the period, on ads buys, printing, and a bevy of consultants. Overall, Fenty has collected $4.38 million since launching his reelection bid last summer." Gray Cash: "Council Chairman Vincent Gray, despite his relatively recent entrance into the race, generated $561,342 and spent $190,134 during the fund raising period, leaving him with $371,208 cash on hand (though he loaned himself $25,000). It's well short of the mayor's bounty, but still a respectable rake given he only joined the race March 30. Gray also appears to have a much larger number of smaller donations than Fenty, in the $50, $100 and $200 range. But if Gray makes headway, the big money donors are certain to come around. They did four years ago when Fenty's grass roots mayoral bid went from underdog to front runner." As WaPo's Tim Craig notes: Gray raised more cash than the mayor in the last three months.
WaPo's Mike DeBonis offers a breakdown of some of the council races with At-Large Councilmember David Catania the big winner with "$204,796 raised this period; $36,501 spent; $302,204 cash on hand." There were also respectable showings from Councilmembers Jim Graham and Mary Cheh.
You can check out the full list at the Office of Campaign Finance [it gave this LL an error when he tried to get past the first page].
FENTY-GRAY FORUM RUMBLE: WaPo's Tim Craig and Ann Marimow report from the third mayoral forum sponsored by the Ward 3 Dems and moderated by beloved former Councilmember Kathy Patterson: "Despite a chorus of boos from the audience, Fenty repeatedly attacked Gray for his service during the Pratt administration, accusing him of being part of a government that nearly bankrupted the city. 'I know Gray supporters don't want to hear the truth,' said Fenty, responding to the boos. 'The Department of Human Services was spending money hand over fist during your leadership.' When Gray got a chance to respond, he leapt to his feet and walked to within a few feet of Fenty. Cheered on by supporters as he shook his finger at the mayor, Gray stated: 'I will put my record up against your record any day. . . . You want to talk about my record, let's get it on.'" Extra Points to Gray for invoking his campaign's theme song.
But wait there's more: "At nearly every chance, Fenty sought to shift the focus back to the Pratt administration. Fenty noted that the Department of Human Services was under 16 court orders under Gray's leadership. He also accused Gray of failing to adequately address juvenile-justice issues in the early 1990s. 'The truth hurts,' Fenty said.
Gray responded: 'How can you be so misinformed?'"
AFTER THE JUMP—Fenty botches interview, what's next for the HIV/AIDS Administration, former supporter becomes headache for mayor, Metro surcharges, and much, much more!
FENTY FUMBLE? Mayor Fenty struggled to answer basic questions during an interview yesterday on FOX5. D.C. Wire's Tim Craig reports: "The Gray campaign is buzzing today about Fenty's appearance this morning on the Fox 5 morning show. It looks like, the Gray campaign says, Fenty's weekly appearance on the show might not be the sort of face time candidates strive to obtain. Appearing on set with the morning anchors, Fenty appeared ill-prepared to answer questions about the triple shooting last night near Howard University, the Washington Post story this morning about questionable DUI arrests in the city, or his views on the Office of Campaign Investigation into whether D.C. Schools Chancellor Michelle Rhee improperly solicited private money to fund the teachers' contract. When asked for an update on the shooting last night near Eighth and V streets NW, Fenty said he hadn't 'gotten a full briefing.'... The hosts then asked Fenty about D.C. Attorney General Peter Nickles's contention that 400 people were recently convicted of driving while intoxicated based on faulty breath tests. Specifically, the anchors wanted to know whether the city was considering restitution for those who were wrongly convicted. 'I actually haven't been briefed on this for several months,' Fenty said." More coverage via The Examiner.
METRO MESS: WTOP reported that Metro workers believe more training would have prevented that 10-car screwup on the Green Line. Unsuck DC Metro has a great YouTube retort. Meanwhile the Examiner's Kytja Weir reports on the staggered fare increases set to begin at the end of this month: "Metro riders saw their fares rise by 10 cents this spring. Now they will see them rise again June 27, then likely change again on Aug. 1....Confused as to how much the commute will cost? Just wait. The confusion will be compounded by complicated fare increases. Metro plans to raise all fares to cover $108 million of an $189 gap in the budget that begins July 1. But the transit agency won't be able to program all the machines and farecards to accept the changes at one time, so it plans at least two phases. Metro board members said Thursday they worry riders may not know what to expect, especially as some of the changes will occur when locals are on vacation just before the July Fourth holiday and during August when Congress has its recess. The agency had pushed the board to make fare decisions early as it said it needed extra time to avoid confusion, noted board member Christopher Zimmerman. But now, he said, 'It seems that nonetheless we are going to have maximum confusion.'" More coverage via WTOP.
But wait there's more...WaPo's Ann Scott Tyson reports surcharges may be hitting riders at six subway stops: "The finance committee of Metro's board of directors approved the option Thursday of imposing yet another five-cent surcharge on entry and exit at two rail stations each in Virginia, Maryland and the District to fund capital improvements to the Metro system at those stations. The full board has yet to agree on the concept or to decide where and when to implement the surcharge. But the catalyst for the idea was a $36 million plan to ease commuter congestion at Union Station, one of Metro's busiest hubs, according to Metro and District officials. No other stations have been proposed for the surcharge, said Catherine M. Hudgins, who represents Virginia and is chairwoman of the finance committee." More coverage via NBC4.
D.C. AIDS PROGRAM: WaPo's Darryl Fears investigates how the city's HIV/AIDS Administration will cope post-Shannon Hader: "The HIV/AIDS Administration is one of the most important agencies in the Department of Health, with an $88 million budget, consisting mostly of federal dollars. The administration is responsible for distributing federal money to D.C. area governments such as Prince George's, Fairfax and Montgomery counties. It is tasked with gathering data and provides federal grants to community organizations for prevention efforts, such as condom distribution, tests for infection and distribution of drugs that lower the level of the virus in those infected....Catania said Hader's departure leaves the city's efforts to fight AIDS in limbo. No one is likely to take the job before the mayoral contest between Fenty and Council Chairman Vincent Gray is decided in September. And it is unlikely that a permanent replacement will be appointed by a mayor before January, Catania said. 'Her loss in catastrophic,' Catania said. But [DOH Director Pierre] Vigilance barely acknowledged Hader while praising Elias at her introduction Tuesday. On Wednesday, activists circulated a blog item on a Web site maintained by Vigilance, under the Watchstone Health Consulting Group, in which he appeared to criticize the city's singular focus on HIV/AIDS. 'There are those who will try to get you to focus on one specific issue because it is politically appropriate to do so,' he wrote. 'It is a failing of public health agencies to allow this to be the case, especially in jurisdictions where multiple health issues challenge the current status and future of some communities.' Dena Iverson, a spokeswoman for the Department of Health, said Vigilance told her that that comment was referring to H1N1 and not HIV/AIDS."
PARKS AND WRECK: WaPo's Mike DeBonis identifies an individual–a former Fenty supporter–that will surely be a huge headache for the mayor:
"Bill Slover is a successful businessman, a family man and active in his community. And he's a major problem for Mayor Adrian M. Fenty (D) in his fight for reelection. That's because Slover is at the center of questions about Fenty's parks contracting — the $100 million in proposed city spending that's fueled accusations of malfeasance that Fenty's foes are flinging freely on the campaign trail. 'What happened with these contracts is one of the worst examples of cronyism I have ever seen in the District of Columbia,' council chairman and Fenty's chief rival, Vincent C. Gray (D), said, latching onto the fact that the mayor's fraternity brothers, Omar Karim and Sinclair Skinner, profited from the parks work. Gray made that claim last week at a mayoral debate, hosted by several Ward 3 community groups, where Fenty was sharply questioned by moderator Davis Kennedy, publisher of the Current community newspapers.
The mayor answered in the same way that he has since the story broke: by seizing on the fact that the contracts were awarded by a subsidiary of the D.C. Housing Authority, which Fenty does not directly control....But what happened to Slover stands in opposition to that claim.
By the time Slover arrived, the parks contracting process was already connected to the mayor. Of the five panel members who selected Karim's Banneker Ventures, three worked for Fenty — one, Jacquelyn Glover, was a project manager working for the deputy mayor for economic development; two others were Parks and Recreation Department employees.
So when the deal came to his attention — a contract solicited through a process that didn't involve bids, included an unusually high fee arrangement for Banneker and kept most control in the mayor's office — Slover grew uncomfortable. He abstained from voting.
In November, after the arrangement was publicized and Slover learned more details about the parks work, he moved to end the authority's involvement in the contract and send it back to the mayor's office.
Some DCHA board members with ties to Fenty, including Deputy Mayor Valerie Santos, objected, and the proposal was tabled. The following week, Slover says, he spoke to City Administrator Neil O. Albert and said he would continue pursuing the resolution. Four hours later, he received a call from Fenty's boards-and-commissions director telling him he'd been removed as chair."
WORLD CUP: NC8 via AP reports that the month-long tournament is expected to become a big cash cow for local bars/restaurants. You should check out our exhaustive guide.
DYRS SUCCESS: Twelve juveniles earned high-school diplomas inside New Beginnings.
HAY-ADAMS: The landmark hotel will be closing for the summer to make way for a multi-million dollar renovation.
MICHELLE OBAMA: Speaks to D.C. grads.
SOMMER MATHIS: The great DCist editor writes her farewell blog post.
KOJO: D.C. Chief Financial Officer Natwar Gandhi and Montgomery County Executive Ike Leggett.
MAYOR'S SCHEDULE: No public events.
D.C. COUNCIL SCHEDULE: No public events.


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Scottsdale Marriott at McDowell Mountains
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Ideas To Aid In Weight-loss Now
... This will likely reduce the chance which you will make use of foods for ease and comfort. Steaming fresh vegetables is the best way to stay away from introducing body fat throughout preparing. You can even use natural herbs, fresh lemon juice, or white vinegar instead of butter. If you choose to saute your vegetables, avoid using gas to put together them. Employing broth or even a flavored white vinegar is a superb substitue for utilizing oil throughout preparation. Avoid ...
After a leisurely breakfast with Linda it was once again back in the car to head South East to Scottsdale, Arizona.
Easy drive of around 5 and a half hours through the desert,
Arrived at Scottsdale at around 1630 hours and we are staying with our friend Sandy Neilson who lives in this fantastic resort style apartment complex. Fantastic to see her again!
Very hot here - around 110 degrees but a dry heat!
Joining the circus
Quick drive from Palm Desert to Scottsdale. Clearly we are now in full desert mode as we passed the Arizona State line, the Grand Canyon State. Even though our internal temperature read 138 it didn't feel that hot since its a "dryheat". Dry heat or not we were still sweating. For those hat have been in Scottsdale, you know there aren't that many Campgrounds nearby. Using my handy app, I found a ...
4444 miles
... since his initial telling of the broken ankle and much relieved to see the apt door open. Actually he was in good spirits considering he has a big cast up to his knee and is not to put ANY weight on it for 6 weeks! A neighbor had just arrived home from the store with supplies for him and I helped carry them up stairs for her. My lupus was fine when I awoke this morn but by the time I arrived at his place I could barely walk-my knees hurt that bad. Took extra pills ...
It's still cold in Arizona-
... dinner her at home tonight and we relaxed and read our books till bed time when we did another chapter of Dracula-we are halfway on it now. Nice warm day and was able to get some sun! My doctors finally called to tell me they haven't done anything about getting me a specialist apt! They are to call back tomorrow! February 19th-Tuesday - I was up at 5 and could not sleep so worked on my jigsaw puzzle for a couple of hours. It is getting cold out again and to rain tonight and ...


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Dedicated to the coverage of UND Hockey. The team formerly known as the Fighting Sioux.
Saturday, January 25, 2014
(Video) Mark MacMillan and North Dakota Strong
This was on last night's broadcast that was on CBSSN... Mark MacMillan has done some great community service.
Posted by Eric Burton at Saturday, January 25, 2014
Labels: Mark MacMillan, University North Dakota
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Travel is my absolute favourite thing to do!
Some beautiful places I've been to that I reccomend:
-Olympic Peninsula, Washington State, US
-Puerto Viejo and Playa Chiquita, Costa Rica
-Bucerias, Nayarit, Mexico
-Koh Lanta Island near Koh Phi Phi and Phuket, Thailand
-Green island, Taiwan
-Luang Prabang, Laos
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Thank you so much!!!! They are beautiful! I couldn't have asked for anything more.
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Best Ever
Best Photographer Ever, Great Job, Sweet,Unforgettable.
She made the experience So Comfortable. Thanks for being so Professional and So Kind. You are part of our Dream Come True.
Mahalo !!!
Forever Grateful
Mariah is an amazing photographer. She goes with the flow and captures familes as they are. I will be forever grateful for capturing my family photos.
Natural Eye
I cannot say enough about how wonderful Mariah is to work with! She is a beautiful person inside and out and I felt immediately comfortable with her from the beginning! She was incredibly fast to respond (email or text!), gave wonderful tips and advice, and made me feel like I was her only client! This all aside from her gifted talent and natural eye for capturing the love between my husband and I. She truly loves Maui and shares that love with you and makes it part of your experience with her in your sessions. I cannot wait to plan our next trip and have Mariah capture those memories for us as well. Maybe next time with our future children!


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"I don't get what all the hullabaloo is."
When it comes to Kate Upton, former Sports Illustrated cover girl Carol Alt doesn't get all the fuss. Alt, who covered the famed 1982 issue, believes that the abundance of attention surrounding the 21-year-old model is a result of social media.
"What I don't understand with Kate is, what's all the hullaballoo?" Alt told HuffPost Live Tuesday. "There are many covers of Sports Illustrated—one girl was just wearing a bottom and [no top]. Actually, a couple times no top and one time just beads. I think that was Marisa [Miller, in 2008]."
"I don't get what all the hullabaloo is," Alt said of Upton. "I think what it is, is that in this moment there's just so much social media and that's why she's had more word of mouth than anybody.
Upton covered the magazine in both 2012 and 2013. And while Nina Agdal, Lily Aldridge, and Chrissy Teigen are featured on this year's cover, Upton snagged the magazine's first ever flip-side cover. People also can't stop buzzing about her zero gravity photo shoot for the magazine's 50th Swimsuit issue. Upton may have defied gravity, but to Alt, she is just another pretty face.
"I like Kate, she's a pretty girl," she continued. "But all the girls are nice, and all the girls are pretty. Every cover, to me, deserves to be talked about."
What do you make of the shade being thrown?
Related Links:
Watch Kate Upton Defy Gravity for Sports Illustrated Because Science
Barbie Defends Her Controversial Sports Illustrated Swimsuit Shoot
Kate Upton is Marilyn Monroe on Vanity Fair's 100th Anniversary Cover


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Sterling Silver Corn on the Cob MiniatureProduct ID: CLF-CS-28183
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Sterling Silver Corn on the Cob Miniature
Material Sterling silver 925
Dimensions 20.3x5.5cm
Estimated processing time: 4-8 Business Days.
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Sterling Silver Corn on the Cob Miniature
This sterling silver miniature features a stalk of corn attached to the cob partially wrapped in leaves and has engraved lines that make this item look real. This item is a fabulous Sukkot gift idea!
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