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Publications (62)87.79 Total impact
Article: Atypical hemolytic uremic syndrome diagnosed four years after ABO-incompatible kidney transplantation: aHUS in allograft kidney[Show abstract] [Hide abstract]
ABSTRACT: Atypical hemolytic uremic syndrome (aHUS) in allograft kidney transplantation is caused by various factors including rejection, infection, and immunosuppressive drugs. We present a case of a 32 year old woman with aHUS four years after an ABO-incompatible kidney transplantation from a living relative. The primary cause of end-stage renal disease was unknown; however, IgA nephropathy (IgAN) was suspected from her clinical course. She underwent pre-emptive kidney transplantation from her 60 year old mother. The allograft preserved good renal function [serum creatinine (sCr) level 110-130 μmol/L] until a sudden attack of abdominal pain four years after transplant, with acute renal failure (sCr level, 385.3 μmol/L), decreasing platelet count, and hemolytic anemia with schizocytes. On allograft biopsy, there was thrombotic microangiopathy in the glomeruli, with a cellular crescent formation and mesangial IgA and C3 deposition. Microvascular inflammation, such as glomerulitis, peritubular capillaritis, and arteriole endarteritis were also detected. A disintegrin-like and metalloproteinase with thrombospondin type 1 motifs 13 (ADAMTS13) did not decrease and Shiga toxin was not detected. Donor-specific antibodies or autoantibodies, including anti-neutrophil cytoplasmic antibody and anti-glomerular basement membrane (anti-GBM) antibody, were negative. The patient was diagnosed with aHUS and received three sessions of plasmapheresis and methylprednisolone pulse therapy, followed by oral methylprednisolone (0.25-0.5 mg/kg) instead of tacrolimus. She temporarily required hemodialysis (sCr level, 658.3 μmol/L). Thereafter, her sCr level improved to 284.5 μmol/L without dialysis therapy. This case is clinically considered as aHUS after kidney transplantation, associated with various factors, including rejection, glomerulonephritis, and toxicity from drugs such as tacrolimus. © 2015 Asian Pacific Society of Nephrology.Nephrology 07/2015; 20 Suppl 2(S2):61-5. DOI:10.1111/nep.12465 · 2.08 Impact Factor
Article: Febuxostat improves endothelial function in hemodialysis patients with hyperuricemia: A randomized controlled study: Febuxostat and endothelial dysfunction[Show abstract] [Hide abstract]
ABSTRACT: Endothelial dysfunction is often found in both hyperuricemia and hemodialysis patients. Recent studies have shown that treating hyperuricemia with allopurinol improves endothelial dysfunction. This study is performed to assess the effect of febuxostat on endothelial dysfunction in hemodialysis patients with hyperuricemia. We randomly assigned 53 hemodialysis patients with hyperuricemia to a febuxostat (10 mg daily) group and a control group and measured flow-mediated dilation, serum uric acid (UA) levels, systolic and diastolic blood pressure, malondialdehyde-modified low-density lipoprotein (MDA-LDL), and highly sensitive C-reactive protein (hsCRP) at baseline and at the end of a 4-week study period. Flow-mediated dilation increased from 5.3% ± 2.4% to 8.9% ± 3.6% in the febuxostat group but did not change significantly in the control group. Treatment with febuxostat resulted in a significant decrease in serum UA level and a significant decrease in MDA-LDL compared with baseline, but no significant difference was observed in hsCRP level or blood pressure. No significant differences were observed in the control group. Febuxostat improved endothelial dysfunction and reduced serum UA levels and oxidative stress in hemodialysis patients with hyperuricemia. © 2015 International Society for Hemodialysis.Hemodialysis International 06/2015; DOI:10.1111/hdi.12313 · 1.24 Impact Factor
Article: Combined IgG4κ and IgG1λ deposition in the glomerular and tubular basement membrane accompanied by autoimmune neutropenia (AIN) and immune thrombocytopenia (ITP)[Show abstract] [Hide abstract]
ABSTRACT: A 48-year-old male was admitted to our hospital with nephrotic syndrome. Light-microscopic examination of a renal biopsy specimen showed almost normal glomerular appearance, however, immunofluorescence examination revealed linear and granular IgG deposits on the glomerular basement membrane (GBM), accompanied by slight IgG deposition in the tubular basement membrane (TBM). Further investigation of the IgG subclass and light chain staining revealed that the glomerular deposits were composed of IgG1 and IgG4, with both κ and λ light chains, while the tubular deposits were composed of only IgG4 and κ light chains. The electron-microscopic findings of small granular deposits in the GBM and TBM closely resembled those of light and heavy chain deposition disease (LHCDD). Immunoelectron microscopy confirmed the presence of κ and λ chains in the GBM and TBM, however, only significant κ chain deposition was found in the TBM. There was no evidence of monoclonal gammopathy. Clinically, the patient subsequently developed neutropenia and thrombocytopenia associated with the presence of anti-neutrophil antibody and anti-GPIIb/IIIa antibody-producing B cells in the blood. Oral steroid administration was initiated, which led to amelioration of the neutropenia, thrombocytopenia and proteinuria. This may be a very rare case of combined IgG4κ and IgG1λ deposition disease accompanied by autoimmune neutropenia (AIN) and immune thrombocytopenia (ITP) suggestive of biclonal immunoglobulin deposition disease (BIDD). Investigation of the IgG subclass and of the light chains was useful for recognizing the clonality of the immunoglobulin deposits in the kidney.02/2015; DOI:10.1007/s13730-015-0170-5
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ABSTRACT: Caveolae on human renal glomerular endothelial cells (HRGECs) are increased in glomerular disease and correlate with the degree of albuminuria. To assess the mechanism by which caveolae contribute to albuminuria, we investigated whether albumin enters into HRGECs through caveolae. HRGECs were incubated with Alexa Fluor 488 labeled BSA or transferrin, followed by immunofluorescence localization with antibody to caveolin-1 (Cav-1), the main structural protein of caveolae, or clathrin, the major structural protein of clathrin coated pits, to assess whether BSA colocalized with Cav-1. HRGECs were also incubated with albumin and caveolae disrupting agents, including methyl beta cyclodextrin (MBCD) and nystatin, to determine whether disrupting caveolae interfered with albumin endocytosis into HRGECs. HRGECs were also incubated with albumin after transfection with Cav-1 small interfering RNAs (siRNAs). Labeled BSA colocalized with Cav-1, but not with clathrin. In contrast, labeled transferrin colocalized with clathrin, but not with Cav-1. Incubation of HRGECs with MBCD or nystatin, or transfection with Cav-1 siRNA, significantly reduced the intracellular amounts of albumin and Cav-1, relative to normal HRGECs, as shown by western blotting and immunofluorescence. These findings indicate that albumin enters HRGECs through the caveolae, suggesting that caveolae play an important role in the pathogenesis of albuminuria by providing a pathway through which albumin can enter glomerular endothelial cells. This article is protected by copyright. All rights reservedJournal of Cellular Biochemistry 01/2015; 116(6). DOI:10.1002/jcb.25061 · 3.26 Impact Factor
Article: Long-Term Prognosis of Adult Patients with Steroid-Dependent Minimal Change Nephrotic Syndrome Following Rituximab Treatment[Show abstract] [Hide abstract]
ABSTRACT: This study was to evaluate the long-term efficacy and safety of a single-dose rituximab regimen rituximab treatment in adult patients with steroid-dependent minimal change nephrotic syndrome (MCNS).We conducted a prospective cohort study with historical controls to evaluate the effect of single-dose infusions of rituximab at 375 mg/m BSA per dose administered at intervals of 6 months for a period of 24 months. At the end of the 24-month period, the patients were divided into the treatment continuation (n = 20) and treatment discontinuation (n = 5) groups according to their intention to continue/discontinue the treatment.A significant reduction in the total number of relapses was observed during the 24-month period after the first rituximab infusion as compared with that during the 24-month period before the first rituximab infusion (108 vs. 8, P < 0.001). Complete remission was induced/maintained in all patients from 12 to 24 months after the first rituximab infusion. In regard to the clinical course after 24 months, 4 of the 20 patients in the treatment continuation group discontinued the rituximab treatment after the fifth infusion and 2 patients discontinued the treatment after the sixth infusion. However, complete remission was maintained in all the 20 patients of this group during the 12-month observation period after the first four single-dose rituximab infusions. On the other hand, 1 of the 5 patients in the treatment discontinuation group developed relapse during the observation period after the first four rituximab infusions, and the rituximab treatment was resumed.In our trial, rituximab therapy was associated with maintenance of complete remission. Complete remission was maintained even in most of the patients who showed B-cell repletion after discontinuation of rituximab therapy. Thus, rituximab may be considered as a radical therapeutic agent for patients with steroid-dependent MCNS.Medicine 12/2014; 93(29):e300. DOI:10.1097/MD.0000000000000300 · 5.72 Impact Factor
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ABSTRACT: Purpose The susceptible age for IgA nephropathy (IgAN) is 60 years, and its characteristics remain unknown. Methods We divided 600 IgAN patients into three groups: advanced-age group (AAG, n = 31, ≥60 years); middle-aged group (MAG, n = 162, 40–59 years); and young-aged group (YAG, n = 407, 20–39 years). We analyzed clinical and histological background, renal outcome, and risk of progression. Results In the AAG, mean arterial pressure (MAP) and the number of hypertensive patients were significantly higher than in the YAG. Total protein, serum albumin, and estimated glomerular filtration rate were significantly lower, and blood urea nitrogen, proteinuria, and N-acetyl-β-d-glucosaminidase were significantly higher in the AAG than in MAG and YAG. In histological findings, interstitial fibrosis/tubular atrophy by Oxford classification and arteriosclerosis were more severe in the AAG than the in YAG. Renal survival rate analyzed by Kaplan–Meier method was significantly lower in the AAG (22.9 %/19 years in the AAG vs. 69.2 and 84.9 %/20 years in the MAG and YAG, p 70 % developed ESRD within 20 years.International Urology and Nephrology 11/2014; 47(1). DOI:10.1007/s11255-014-0872-1 · 1.52 Impact Factor
Article: Comparison of a novel chemiluminescence enzyme immunoassay (CLEIA) with enzyme-linked immunosorbent assay (ELISA) for the determination of MPO-ANCA in patients with ANCA-associated vasculitis[Show abstract] [Hide abstract]
ABSTRACT: Background: Myeloperoxidase (MPO) anti-neutrophil cytoplasmic antibody (ANCA) represents the serological hallmark of ANCA-associated vasculitis (AAV). We evaluated the analytical and diagnostic accuracy of chemiluminescence enzyme immunoassay (CLEIA) versus enzyme-linked immunosorbent assay (ELISA) for the detection of MPO-ANCA. Methods: A total of 242 sera obtained from 51 patients with AAV and 103 patients without AAV were tested for MPO-ANCA by ELISA (NephroScholor MPOANC II) and CLEIA (the STACIA MEBLux test). Disease activity in the patients with AAV was determined based on the Birmingham Vasculitis Activity Score. We analyzed the correlations between the MPO-ANCA titers determined by the CLEIA and those determined by the ELISA, and also between the MPO-ANCA titers and the disease activity. Results: The MPO-ANCA titers determined by the CLEIA (x) were strongly correlated with those determined by the ELISA (y). The correlation could be expressed by the following equation in this study: y = 1.8x + 7.7 (r = 0.96; p < 0.0001). At the cutoff value of 3.5 U/ml, the CLEIA yielded positive test results for MPO-ANCA in 73 of the 242 sera (30.2%), while at the cutoff value of 20 U/ml, ELISA yielded positive test results in 57 of the 242 sera (23.6%). The CLEIA yielded false-positive test results in 4 of the 120 sera obtained from the non-AAV patients (3.3%), whereas the ELISA yielded a false-positive result in only 1 of the 120 sera obtained from the non-AAV patients (0.8%). The sensitivity and specificity of the CLEIA for the diagnosis of AAV were 100% and 96.7%, respectively, while those of the ELISA were 94.3% and 99.2%, respectively. The sensitivity and specificity of the CLEIA for the prediction of active disease were 100% and 64.4%, respectively, while those of the ELISA were 94.3% and 73.6%, respectively. Conclusion: The false positivity rate of the CLEIA for MPO-ANCA tended to be high as compared with that of the ELISA. Also, according to the correlation coefficient between the results of the CLEIA and the ELISA calculated in this study, it is necessary to pay attention to the differences in the sensitivity and specificity between CLEIA and ELISA.Modern Rheumatology 11/2014; 25(2):1-5. DOI:10.3109/14397595.2014.951113 · 2.40 Impact Factor
Article: High uric acid level is a risk factor for progression of IgA nephropathy with chronic kidney disease stage G3a[Show abstract] [Hide abstract]
ABSTRACT: Background: High uric acid level is a known risk factor for deterioration of renal function in chronic kidney disease (CKD), but its influence on the progression of IgA nephropathy (IgAN) remains unclear. Methods: Adult IgAN patients (n = 611) were classified according to CKD stage. Renal survival rates and clinical and histological findings were compared between patients with high (H-UA) and normal (N-UA) uric acid levels in different CKD stages. Results: The proportion of patients with H-UA increased significantly with increasing CKD stage (stage G1, 12.3%; stage G2, 19.0%; stage G3a, 43.7%; stage G3b-4, 69.0%; P < 0.001). The 30-year renal survival rate was similar in patients with H-UA and N-UA in CKD stages G1, G2, and G3b-4, but was significantly lower in patients with H-UA than with N-UA in CKD stage G3a (24.7 vs. 51.9%; P = 0.0205). The clinical findings were similar in patients with H-UA and N-UA, but the interval from onset to biopsy differed between groups. The proportion of patients with global sclerosis was significantly higher in patients with H-UA than with N-UA in CKD stage G3a (33.3 vs. 11.4%; P = 0.0005), but the Oxford classifications were similar between groups. Multivariate Cox regression analysis identified H-UA (HR 1.36, 95% CI 1.07-1.72, P = 0.011) and a large amount of proteinuria (HR 1.38, 95% CI 1.09-1.74, P = 0.0084) as independent predictors of end-stage renal disease. Conclusions: H-UA induced global glomerular sclerosis and accelerated the progression of IgAN in CKD stage G3a.Journal of nephrology 10/2014; 28(4). DOI:10.1007/s40620-014-0154-0 · 1.45 Impact Factor
Article: Switching from allopurinol to febuxostat for the treatment of hyperuricemia and renal function in patients with chronic kidney disease[Show abstract] [Hide abstract]
ABSTRACT: Hyperuricemia is a frequent complication of chronic kidney disease (CKD). Febuxostat is a novel xanthine oxidase inhibitor that is metabolized by many metabolic pathways in the kidney and the liver. We performed a 1-year cohort study of 73 hyperuricemic patients who had an estimated glomerular filtration rate (eGFR) below 45 ml/min and were being treated with urate-lowering therapy. In 51 patients, treatment was changed from allopurinol to febuxostat, and the other 22 patients were continued on allopurinol. The serum levels of uric acid (UA) level, creatinine, and other biochemical parameters were measured at baseline and after 3, 6, 9, and 12 months of treatment. The serum UA levels significantly decreased from 6.1 ± 1.0 to 5.7 ± 1.2 mg/dl in the febuxostat group and significantly increased from 6.2 ± 1.1 to 6.6 ± 1.1 mg/dl in the allopurinol group. The eGFR decreased 27.3 to 25.7 ml/min in the febuxostat group and from 26.1 to 19.9 ml/min in the allopurinol group. The switch from allopurinol to febuxostat was significantly associated with the changes in eGFR according to a multiple regression analysis (β = -0.22145, P < 0.05). Febuxostat reduced the serum UA levels and slowed the progression of renal disease in our CKD cohort in comparison with allopurinol.Clinical Rheumatology 07/2014; 33(11). DOI:10.1007/s10067-014-2745-5 · 1.70 Impact Factor
Article: Prognosis in IgA Nephropathy: 30-Year Analysis of 1,012 Patients at a Single Center in Japan[Show abstract] [Hide abstract]
ABSTRACT: Little is known about the long-term prognosis of patients with IgA nephropathy (IgAN). This retrospective cohort analysis evaluated clinical and histological findings at the time of renal biopsy, initial treatment, patient outcomes over 30 years, and risk factors associated with progression in 1,012 patients diagnosed with IgAN at our center since 1974. Of the 1,012 patients, 40.5% were male. Mean patient age was 33±12 years and mean blood pressure was 122±17/75±13 mmHg. Mean serum creatinine concentration was 0.89±0.42 mg/dL, and mean estimated glomerular filtration rate (eGFR) was 78.5±26.2 ml/min/1.73 m2. Mean proteinuria was 1.19±1.61 g/day, and mean urinary red blood cells were 36.6±35.3/high-powered field. Histologically, mesangial hypercellularity was present in 47.6% of patients, endothelial hypercellularity in 44.3%, segmental sclerosis in 74.6%, and tubular atrophy/interstitial fibrosis in 28.8% by Oxford classification. Initial treatment consisted of corticosteroids in 26.9% of patients, renin-angiotensin-aldosterone system inhibitor in 28.9%, and tonsillectomy plus steroids in 11.7%. The 10-, 20-, and 30-year renal survival rates were 84.3, 66.6, and 50.3%, respectively. Tonsillectomy plus steroids dramatically improved renal outcome. Cox multivariate regression analysis showed that higher proteinuria, lower eGFR, and higher uric acid at the time of renal biopsy were independent risk factors for the development of end stage renal disease (ESRD). IgAN is not a benign disease, with about 50% of patients progressing to ESRD within 30 years despite treatment.PLoS ONE 03/2014; 9(3):e91756. DOI:10.1371/journal.pone.0091756 · 3.23 Impact Factor
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ABSTRACT: Background: The renoprotective pleiotropic effect of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) has recently been reported by several investigators. However, the effect of statins on IgA nephropathy (IgAN) is still unknown. Methods: We selected 24 IgAN patients who had newly started statin therapy and were not treated with steroids and immunosuppressive agents during the observation period. We analyzed and compared clinical findings 1 year before and after treatment. Results: Mean age was 50.5 ± 9.91 years and mean blood pressure was 90.9 ± 10.8 mmHg. Renal function was slightly deteriorated, serum creatinine was 1.03 (0.71-1.24) mg/dL and estimated glomerular filtration rate (eGFR) was 55.8 ± 22.8 mL/min. Lipid metabolism was poorly controlled [total cholesterol 247.7 ± 35.7 mg/dL, low-density lipoprotein cholesterol 151.5 (140.8-172.8) mg/dL, and triglyceride 163.0 (126.3-243.8) mg/dL]. Mild urinary abnormality was observed [proteinuria: 0.50 (0.22-1.29) g/g creatinine, urinary red blood cells 1.0 (0.2-5.0) per high power field]. After 1 year of statin treatment, lipid control was significantly better than at baseline. Proteinuria was not significantly decreased but renal function was improved. eGFR changed from a -5.9% decrease to a 2.4% increase (p = 0.0098). Conclusion: Our results indicated that statins stabilized the renal function of IgAN patients independent of their reduction of proteinuria.Renal Failure 12/2013; 36(3). DOI:10.3109/0886022X.2013.866512 · 0.94 Impact Factor
Article: A novel autoantibody against moesin in the serum of patients with MPO-ANCA-associated vasculitis[Show abstract] [Hide abstract]
ABSTRACT: Antineutrophil cytoplasmic autoantibody (ANCA) directed against myeloperoxidase (MPO), a diagnostic criterion in MPO-ANCA-associated vasculitis (MPO-AAV), does not always correlate with disease activity. Here, we detected autoantibodies against moesin, which was located on the surface of stimulated endothelial cells, in the serum of patients. The anti-moesin autoantibody titer was evaluated by ELISA. Seventeen kinds of cytokines/chemokines were measured by a Bio-Plex system. Serum creatinine in the anti-moesin autoantibody-positive group was higher than that in the negative group. Additionally, interferon (IFN)-γ, macrophage chemotactic peptide-1 (MCP-1), interleukin (IL)-2, IL-7, IL-12p70, IL-13, granulocyte/macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor were significantly higher in the positive group. Furthermore, IL-7 and IL-12p70 levels correlated with the anti-moesin autoantibody titer. Based on these findings and the binding of anti-moesin IgG to neutrophils and monocytes, we detected the secretion of cytokines/chemokines such as IFN-γ, MCP-1 and GM-CSF from these cells. The anti-moesin autoantibody existed in the serum of patients with MPO-AAV and was associated with the production of inflammatory cytokines/chemokines targeting neutrophils with a cytoplasmic profile, which suggests that the anti-moesin autoantibody has the possibility to be a novel autoantibody developing vasculitis via neutrophil and endothelial cell activation.Nephrology Dialysis Transplantation 12/2013; 29(6). DOI:10.1093/ndt/gft469 · 3.58 Impact Factor
Article: Clinical and Pathological Studies of IgA Nephropathy Presenting as a Rapidly Progressive Form of Glomerulonephritis[Show abstract] [Hide abstract]
ABSTRACT: Objective: IgA nephropathy (IgAN) is widely regarded as a slowly progressive disease. However, a minor population of patients present with a rapidly progressive form of glomerulonephritis (RPGN). Methods: We studied 25 cases of IgAN who presented with RPGN. The laboratory data, histology, and five-year prognosis after diagnostic renal biopsy were evaluated. We compared the data of these patients with those of 495 patients with the non-RPGN type. In addition, we divided the patients with the RPGN type of IgAN into a group with reduced renal function and a group with maintained renal function, and compared the data between the two groups. Results: In the 'RPGN type', the serum creatinine levels and a 24-hour urinary protein excretion were significantly higher than in the non-RPGN type. Histological examinations showed that the rates of endocapillary hypercellularity and tubular atrophy/interstitial fibrosis were significantly higher in the patients with the RPGN type. In the comparison between the groups with reduced and maintained renal functions, the former group exhibited higher levels of proteinuria, serum creatinine and crescent formation than the latter group. Conclusion: The RPGN type of IgAN was significantly worse in terms of the renal survival rate at five years than the non-RPGN type. Intensive and active treatments are necessary for this minor population, according to the guideline for the management of RPGN.Internal Medicine 11/2013; 52(22):2489-94. DOI:10.2169/internalmedicine.52.0420 · 0.90 Impact Factor
Article: The necessity of the addition of interstitial pathological parameters on the glomerular histological classification to predict the long-term outcome in MPO-ANCA-associated RPGN cohort in JapanLa Presse Médicale 04/2013; 42(4):667. DOI:10.1016/j.lpm.2013.02.040 · 1.08 Impact Factor
Article: Long-term damage assessment in patients with microscopic polyangiitis and renal-limited vasculitis using the Vasculitis Damage Index[Show abstract] [Hide abstract]
ABSTRACT: Objectives: The Vasculitis Damage Index (VDI) is used to define the degree of damage occurring in patients with systemic vasculitis. We conducted a retrospective study of 30 patients with microscopic polyangiitis (MPA) and renal-limited vasculitis (RLV). Methods: The clinical data and VDI of the 30 patients enrolled in the study were collected and assessed for a period of 5 years. Result: The VDI score, which was 2.5 at 1 year after the initial diagnosis, increased gradually to 4.3 at 5 years post-diagnosis. The degrees of musculoskeletal and ocular damage significantly increased during the 5-year period (p = 0.001 and p = 0.002, respectively). The most frequent damage items in the VDI were cataract (13 %), hypertension (12 %), diabetes mellitus (9 %), and osteoporosis (6 %). The VDI score was significantly higher in the groups of patients who showed relapse or MPA than in the groups of patients who did not show relapse or RLV at 5 years (p = 0.02 and p = 0.03, respectively). In addition, a significant correlation was found between the VDI score at 5 years and the Birmingham Vasculitis Activity Score at diagnosis (p = 0.04, r = 0.4). Conclusion: The VDI was found to be a useful tool for determining the severity of damage caused by disease and the effects of treatment. The individual contributions of the VDI items may also be applied to treatment decisions.Modern Rheumatology 01/2013; 24(1). DOI:10.1007/s10165-012-0829-0 · 2.40 Impact Factor
Article: Effects of Combination Therapy with Renin-Angiotensin System Inhibitors and Eicosapentaenoic Acid on IgA Nephropathy[Show abstract] [Hide abstract]
ABSTRACT: Objective: The beneficial effects of renin-angiotensin-aldosterone system inhibitors (RASI) and the omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) on IgA nephropathy (IgAN) have been reported. However, it is unknown whether these agents have any synergistic interactions. Methods: We divided 38 IgAN patients into two groups: an EPA group (n=18) treated with RASI plus EPA and a DILAZEP group (n=20) treated with RASI plus dilazep dihydrochloride. We analyzed the clinical and histological background of each patient, any relevant clinical findings obtained one year after treatment and any factors significantly related to decreases in proteinuria. Results: The clinical findings were largely similar between the groups, except for body mass index (24.9±4.5 in the EPA group vs. 21.4±2.1 in the DILAZEP group, p=0.0041) and total cholesterol (median: 206.0 vs. 177.5 mg/dL, p=0.0493). The histological findings, evaluated according to the Oxford classification, were also similar between the groups. At one year after treatment, the EPA group demonstrated a significantly decreased mean blood pressure (from 94.7±9.0 to 86.4±7.2 mmHg, p=0.0007) and a significantly decreased median level of proteinuria (from 0.80 to 0.41 g/g creatinine, p<0.001). In the DILAZEP group, the mean blood pressure significantly decreased (from 95.2±13.2 to 88.1±7.7 mmHg, p<0.001) without any significant decrease in the median level of proteinuria (from 0.88 to 0.60 g/g creatinine). According to a multivariate logistic analysis, EPA was found to be the only independent factor related to decreases in proteinuria (odds ratio = 5.073, 95% CI: 1.18-26.7, p=0.0285). Conclusion: We conclude that EPA accelerates the effects of RASI and thus decreases the proteinuria observed in patients with IgAN.Internal Medicine 01/2013; 52(2):193-9. DOI:10.2169/internalmedicine.52.8323 · 0.90 Impact Factor
Article: Evaluation of the newly proposed simplified histological classification in Japanese cohorts of myeloperoxidase-anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in comparison with other Asian and European cohorts[Show abstract] [Hide abstract]
ABSTRACT: The prognostic value of renal biopsy in anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis is widely recognized; however, there is no consensus regarding its pathological classification. Berden et al. proposed a new classification of glomerulonephritis in ANCA-associated vasculitis (AAV) categorized into focal, crescentic, mixed, and sclerotic classes and showed its prognostic value in 100 international multicenter cohorts for 1- and 5-year renal outcomes. In order to evaluate whether this new classification has predictive value and reproducibility in Japanese AAV cases, 87 cohorts with only microscopic polyangiitis in 3 limited centers in Japan were analyzed. In addition, those from Japan, Europe (Berden's cohorts) and China were compared in a recent report.Clinical and Experimental Nephrology 12/2012; 17(5). DOI:10.1007/s10157-012-0755-7 · 2.02 Impact Factor
Article: Effect of single-dose rituximab on steroid-dependent minimal-change nephrotic syndrome in adults[Show abstract] [Hide abstract]
ABSTRACT: Background Steroid-dependent minimal-change nephrotic syndrome (MCNS) requires administration of prolonged courses of prednisolone (PSL); therefore, a paradigm shift from such toxic 'non-specific' therapies to selective immunomodulating regimens is necessary for these cases.Methods To assess the therapeutic effects of rituximab (an anti-CD20 antibody) in adult patients with steroid-dependent MCNS, we performed a prospective trial of the effects of a single dose of rituximab administered twice at an interval of 6 months in 25 MCNS patients. We evaluated the biochemical parameters and compared the clinical findings between the 12-month period before and 12-month period after the first rituximab infusion.ResultsA significant reduction in the number of relapses and the total dose and the maintenance dose of PSL administered was observed during the 12-month period after the first rituximab infusion when compared with the findings during the 12-month period before the first rituximab infusion [25 (100%) versus 4 (16%), P < 0.001; 8.2 versus 3.3 g, P < 0.001; 26.4 mg/day at baseline versus 1.1 mg/day at 12-month, P < 0.0001]. Complete remission was achieved/maintained in all patients undergoing B-cell depletion. Four of 17 patients with B-cell repletion developed relapse.Conclusions Our results revealed that rituximab therapy was associated with a reduction in the number of relapses and in the total dose of PSL needed. Therefore, rituximab appears to be a useful therapeutic agent for adult patients with steroid-dependent MCNS. These results suggest that this treatment is rational and should be considered as an important option in the management of adult patients with steroid-dependent MCNS.Nephrology Dialysis Transplantation 12/2012; 28(5). DOI:10.1093/ndt/gfs515 · 3.58 Impact Factor
Article: Positive C1q staining associated with poor renal outcome in membranoproliferative glomerulonephritis[Show abstract] [Hide abstract]
ABSTRACT: Background: Pathogenesis and clinical prognosis of membranoproliferative glomerulonephritis (MPGN) has not yet been established. Methods: We conducted a retrospective study of 41 patients with MPGN (type I and III) and examined the renal survival. In addition, factors contributing to survival time were analyzed. Results: Fourteen patients (34 %) were classified into the renal death group. Patients with nephrotic syndrome and positive C1q staining of glomerular deposits showed a particularly poor prognosis. Significantly higher frequency of nephrotic syndrome and higher urinary protein excretion were observed in the renal death group (p = 0.0002, p = 0.0002) than in the renal survival group. The intensity of C1q staining was positively correlated with the severity of the proteinuria (p = 0.004). Factors that influenced the survival time were positive C1q staining of glomerular deposits (p = 0.003), presence of nephrotic syndrome (p = 0.004), serum albumin (p = 0.02), and proteinuria (p = 0.04). Conclusions: C1q staining in glomerular deposits and nephrotic syndrome were important factors influencing the prognosis and outcome in MPGN patients. C1q deposition may play a key role in the pathogenesis of MPGN, as evidenced by numerous observations, such as induction of proteinuria.Clinical and Experimental Nephrology 07/2012; 17(1). DOI:10.1007/s10157-012-0667-6 · 2.02 Impact Factor
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ABSTRACT: IgA nephropathy with nephrotic syndrome (nephrotic IgAN) is a rare form of IgAN. Its prognosis and response to steroid therapy are still controversial because the differential diagnosis between nephrotic IgAN and minimal change nephrotic syndrome with IgA depositions is sometimes confused. In this retrospective cohort analysis, we accurately diagnosed 42 cases of nephrotic IgAN (4.4%) from 954 IgAN patients, according to the Oxford classification. We analyzed the clinical and histological data, prognosis, and response to steroid therapy. In nephrotic IgAN, mean estimated glomerular filtration rate (eGFR) was 51.1 ± 24.6 ml/min, proteinuria was 5.71 ± 2.56 g/day, and urinary red blood cells were 51.0 ± 37.8 high power field. Both active and chronic histological lesions were observed. Cumulative renal survival rate was significantly lower in nephrotic IgAN than in non-nephrotic IgAN (the control group consisted of 47 non-nephrotic IgAN patients diagnosed between 1995 and 1996) (log-rank test: P < 0.0001). The cases with steroid therapy significantly improved their prognosis, though their male-to-female ratio and blood pressure level measured at renal biopsy were significantly lower than in the cases without steroid therapy. Steroid therapy was particularly effective in cases with low-grade tubular atrophy and interstitial fibrosis (T-grade in Oxford classification). Without steroid therapy, lower eGFR and higher T-grade were independent risk factors for severe outcome by multivariate Cox regression. Nephrotic IgAN is a very severe form of IgAN, with renal dysfunction, massive hematuria, and active and chronic histopathological lesions. Renal outcome is severe; however, steroid therapy can improve prognosis in cases with higher eGFR and lower T-grade, according to the Oxford classification.International Urology and Nephrology 01/2012; 44(4):1177-84. DOI:10.1007/s11255-011-0109-5 · 1.52 Impact Factor
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Tokyo Women's Medical University
Edo, Tōkyō, Japan
- • School of Medicine
- • Department of Pathology II
Tokyo Junshin Women's College
Edo, Tōkyō, Japan
- Department of Internal Medicine


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One of my company's websites is using Drupal 6. I'm attempting to us hook_js_alter (from the jsalter module) to use jQuery 1.8.3 on the front-end rather than what Drupal is currently using (1.3.2).
I'm very new to Drupal (background is in WordPress), so things like this that might be obvious to experienced Drupal developers aren't to me.
I've already installed the module in the admin.
This is the code I'm using based on other stuff floating around google:
function hook_js_alter(&$js) {
if (isset($js['misc/jquery.js'])) {
$jsPath = 'https://ajax.googleapis.com/ajax/libs/jquery/1.8.3/jquery.min.js';
$js['misc/jquery.js']['data'] = $jsPath;
$js['misc/jquery.js']['version'] = '1.8.3';
Where do I put this code? I've tried placing it in the header of my template (before the
<?=$scripts?> tag) but it's not working there. Is this code even right?
I'm having a difficult time finding the instructions necessary to accomplish this with Drupal 6 so links to documentation or a tutorial would be really helpful.
EDIT: Just realized there is Drupal Stack Exchange. This question should probably be migrated there.

subset: commoncrawl


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2008 Toyota Camry • 93,000 miles
I changed spark plugs a few days back because the car gave a cylinder misfire report. Today the car was vibrating on increased acceleration or climbing a height and check engine sign comes on. The check engine sign is permanently on now.
September 23, 2013.
September 23, 2013.
Spark plugs are a maintenance item and rarely repair any issues.
Have the codes read and post the numbers here.
Have the codes read and post the numbers here.
Sep 23, 2013.
Sep 23, 2013.
Improperly gapped plugs, or the wrong plug type may cause a misfire. A carbon track on your coil boots can cause the same. I agree with wrenchtech. Get it scanned, and post codes.
Oct 1, 2013.
Oct 1, 2013.
When i start my truck i hear and ticking noise and it does NOT go away after it warms up or it does not go away at all. When i accelerate the ticking noise gets faster and when im ...
5 answers • 2010 Chevrolet Suburban • 143,000 miles
I am replacing my engine in my 2003 Hyundai Tiburon. It is a 4 cylinder vehicle, but all the engines I am able to find are 6 cylinder engines. Is it possible to replace a the 4 cylinder...
1 answer • 2003 Hyundai Tiburon • 132,000 miles
If i took out my 91 toyota carolla engine what other cars would it be compatible with?
4 answers • 1991 Toyota Corolla
1990 Toyota Camry mileage: 150,000. 1. The oil warning light is on. 2. There are four quarts of oil in the car. 3. The oil filter is dry. 4. The engine sounds rough. 5. There is noise ...
3 answers • 1990 Toyota Camry • 150,000 miles


text: http://forums.opensuse.org – So openSUSE 11.3 comes with the SpiderOak client ready to install from the repos. If you haven't seen it, SO is an online backup and sync service, the big advantage compared to competing services like Dropbox is the zero-knowledge approach: everything is encrypted right on your machine, all they can know is how much data you are saving. You get 2 GB for free, but they have a referral program where both parties get 1 GB extra. Here's my referrer link, if you use it to sign up you start with 3GB and I get 1 GB extra too, win-win. (Distributions)


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Montalvo Family - Carving the Faith
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text: Thinkstock One of Today's Hottest Trends Could Soon Require a Warning Label, and Not Because They Make Your Butt Look Good By Tammy July 20, 2015 Have you noticed more heartburn symptoms and swelling or tingling in your legs? The cause may be one of today's hottest fashion trends. Read More|Comment Category: Articles, Health & Lifestyle, Homepage Tags: That's Life Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


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Fire doesn't stop shoppers for rare, used books at landmark Oklahoma City bookstore
"If the fire had gotten to these books, the majority of them are older books, so they are drier," Walker said. "It would have been a really big fire."
The fire put a dent in her Christmas season business. A number of customers said they would rather wait until the electricity was restored and the heat back on before trying to shop for books.
Aladdin Book Shoppe opened downtown in 1930. For many years it was located at NW 24 and N Pennsylvania Avenue before moving to the Mayfair location.
Despite smoke and water damage to the building, most of the books are intact and only three books appeared damaged from water that leaked from the ceiling, Walker said
She said this was the second fire in recent years that started in the awning.
Fire investigators have not determined the exact cause, but it could be electrical.
Walker said the shop will remain open despite the fire.
"It's chilly and dark but we're doing business by flashlight and headlamp. I'm providing the headlamps," Walker said.


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Easy to use
By thegooddaughter
from New York, NY
Comments about GE 23.75" Single Gas Wall Oven - White on White:
I bought this oven for my 88 year old dad and it is easy to use.
Bottom Line Yes, I would recommend this to a friend
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I needed to replace my oven. i went online to research all ovens, The GE had the highist review. Plus it had all the feathers I was looking for. I am very pleased.
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The Book of Mormon is probably the least read and most criticized of all books. An awesome book detailing the spiritual, political and social events that took place in the Americas.
It gets a little hard to follow in 2nd Nephi where Nephi quotes from Isiah quite a bit. But it is worth plowing through it to the rest of this amazing book.
See it as donating a moment of your social media time, every little thing helps us improve and stay online.
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iSpyoo Spy App for Android
Quick Specs
Total Downloads:44,636
Date Added:Mar. 26, 2015
Price:Free to try (48-hour trial); $16.99 to buy (Buy it now)
File Size:1.27MB
Downloads Last Week:349
Product ranking:#5 in Monitoring Software
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From iSpyoo: iSpyoo Mobile Spy, Spy Phone App For Android- Cell Phone Spy Software silently monitors your child or employee's smartphone activity on iPhone, Android and other mobile phones. This small apps record everything (whatsapp chats, text messages, any password like Facebook, gmail, yahoo mail) and send to you by email the report key logs. Track the location of somebody. Read the content of his/her messages and discover the truth. Get a copy of his/her calling history. Keylogger for iPhone, iPad, iPodTouch, Android You can record all detailed keystrokes including passwords typed. Receive Logs reports via E-mail.
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Hertsmere Borough Council held its annual civic service at Bushey United Synagogue, where the current mayor, Cllr Linda Silver, and her husband Geoffrey, have been members for almost 40 years.
Joining the 200-plus gathering were fellow mayors from across the county, MP James Clappison and Hertfordshire Deputy Lord Lieutenant Stuart Nagler, himself a former Hertsmere mayor.
Mourners at a Bushey cemetery funeral are facing expensive vehicle repairs after "malicious" vandalism.
They discovered the damage following the funeral of Alan and Rochelle Bernard, who died after a car collided with them as they walked along a road to their holiday home in Dorset.
Graham Temple from Radlett, who had known the Bernards for more than 30 years, said the funeral had been attended by 800 people. "Even though we got there early, the car park had filled and many vehicles were parked along the grass verge outside the cemetery. I estimate there must have been 40 to 50.
A-level results this year have attracted particular interest because of the introduction of the new A* grade. And many Jewish pupils were star-struck.
At JFS, 48 per cent of grades were As or A*s and more than three-quarters of the 489 results were grade B or above.
Eighty per cent of Immanuel exams were passed at grades of B or better. And King Solomon High School pupils recorded a 99 per cent pass rate overall, with nearly three-quarters gaining a C grade or above.
Bushey Synagogue congregants are praying that normal services can be resumed as soon as possible - and certainly by the High Holy-Days.
As part of phase two of the shul's £1.2 million refurbishment scheme, the main synagogue has been completely gutted.
So for the summer holiday period, the community has decamped for Shabbat services to Immanuel College, half-a-mile away.
A £10.6million Jewish Blind and Disabled development of mobility apartments has been given the green light by Hertsmere Council. The Bushey project will incorporate 39 one-bedroom apartments for physically disabled or vision impaired people of all ages and two apartments for full-time on-site house managers.
It was only a little article on the JC's website but it was one of the most heart-warming to read in a while. Yet again, Israel - so often the subject of bad press around the world - was rapidly responding with real aid to a humanitarian crisis.
Immanuel College is to open a junior school at its Bushey campus in September 2011, in response to the growing demand for Jewish primary places in Hertfordshire.
The independent school will start with classes for reception and year one, with 20 places available in each. Initially at least, the junior section will be contained in existing premises.
A young professional poker player lost £156,000 at the High Court today when a judge ruled he must pay a rabbi who placed spread bets for him on the Dow Jones index.
Simon Nissim said he would give any winnings from his on-line spread betting to Andrew Feldman, 22, who had lost more than £700,000 at cards.
But Mr Feldman agreed to cover any losses, and ended up with a bill for £136,000.
He had asked deputy High Court judge Richard Snowden QC to set aside a statutory demand for the money served on him by the 34-year-old rabbi.
Grandmother Linda Silver, who has been involved in local politics for 36 years, will next week take office as the Mayor of Hertsmere.
The Bushey and District Synagogue member was elected as a Hertsmere councillor in 1974 and has been a Tory whip in Hertsmere and an adviser to the Conservative group on Brent Council.
Her mayoral charities will be Jewish mental health support organisation Jami and Help for Heroes, in memory of her father, who served as a colonel in the Royal Engineers.


text: Schools for Growth: Radical Alternatives to Current Educational Models By Lois Holzman No cover image Schools for Growth: Radical Alternatives to Current Educational Models By Lois Holzman Read preview Synopsis A passionate deconstruction and reconstruction of learning, development, and schooling that urges teachers to explore and create new educational opportunities for themselves and their students, Schools for Growth: Radical Alternatives to Current Educational Models asks the following questions: Can we create ways for people to learn the kinds of things that are necessary for functional adaptation without stifling their capacity to continuously create their growth? Can schools become environments that support children to perform not only as learners but as developers of their lives? This book challenges educators to look at the deeply-rooted assumptions about schooling, learning, and development and urges that the way psychology and education have constructed our conceptions of what it means to teach, to learn, and to grow may be the most serious impediment to the learning and developing of children. Beyond the criticism, the author presents an original methodological reformation of what learning and development are as relational activities and then takes readers on a visit to three radical independent school settings. Arguing that current educational models have been misguided by scientific psychology, the author states that the dominant model of human development actually hinders development. Moreover, as learning theory has become infused with developmental theory over the past 30 years, the overly cognitive manner in which psychologists have come to think about thinking, learning, and development has become further insinuated into education. Both theories--learning and developmental--fail o recognize the human capacity for relational-revolutionary activity and for performance. The prevalent mode of education--acquisitional learning--is grounded in a world view that gives primacy to knowledge and knowing which Holzman believes is inconsistent with ongoing developmental activity. The author focuses on "developmental learning"--a social constructionist, activity-theoretic conception of development which includes a transformation and synthesis of Vygotsky and philosopher Ludwig Wittgenstein. She also discusses educational projects that are self-conscious attempts to break with key elements of modern epistemology and the dominant psychological paradigm as they are perpetrated in contemporary educational theory and practice. Their specific philosophies and practices highlight important methodological issues raised in the attempt to create "postmodern schools"--schools more concerned with growing than knowing. Related books and articles Books Journals Magazines Newspapers Encyclopedia A School for Healing: Alternative Strategies for Teaching At-Risk Students By Rosa L. Kennedy; Jerome H. Morton Peter Lang, 1999 Read preview Overview Charter Schools in Eight States: Effects on Achievement, Attainment, Integration, and Competition By Ron Zimmer; Brian Gill; Kevin Booker; Stephane Lavertu; Tim R. Sass; John Witte Rand, 2009 Read preview Overview Constructions of Literacy: Studies of Teaching and Learning in and out of Secondary Schools By Elizabeth B. Moje; David G. O'Brien Lawrence Erlbaum Associates, 2001 Read preview Overview Misuse and Abuse of the Lsat: Making the Case for Alternative Evaluative Efforts and a Redefinition of Merit By Haddon, Phoebe A. Post, Deborah W. St. John's Law Review, Vol. 80, No. 1, Winter 2006 Read preview Overview Integrating Complementary and Alternative Medicine Education into the Pharmacy Curriculum By Tiralongo, Evelin Wallis, Marianne American Journal of Pharmaceutical Education, Vol. 72, No. 4, August 2008 PEER-REVIEWED PERIODICAL Peer-reviewed publications on Questia are publications containing articles which were subject to evaluation for accuracy and substance by professional peers of the article's author(s). Read preview Overview The Social Construction of Alternative Education: Re-Examining the Margins of Public Education for At-Risk Chicano/a Students By High School Journal, Vol. 88, No. 2, December 2004 PEER-REVIEWED PERIODICAL Peer-reviewed publications on Questia are publications containing articles which were subject to evaluation for accuracy and substance by professional peers of the article's author(s). Read preview Overview Beacons of Hope: SECME Inc. Partners with Minority-Serving Institutions to Create Alternative High Schools to Increase High School, College Completion Rates. (Top 100: 2001-2002) By Brotherton, Phaedra Black Issues in Higher Education, Vol. 20, No. 8, June 5, 2003 Read preview Overview Proposed Bible Course Sparks Controversy in Memphis Schools By Church & State, Vol. 54, No. 1, January 2001 Read preview Overview A Solution to the Dangers of Teaching Evolution in Public Schools: The Creation-Evolution Continuum By Scott, Eugenie Skeptic (Altadena, CA), Vol. 10, No. 4, Winter 2004 Read preview Overview More No. 2 Pencils at Alternative Schools By Marjorie Coeyman, writer of The Christian Science Monitor The Christian Science Monitor, February 8, 2000 Read preview Overview Alternative School Gives Second Chances By Barnes, Denise The Washington Times (Washington, DC), March 14, 2003 Read preview Overview Education Should Be Customized to Meet Students' Needs; Charter Schools Offer Needed Reforms By Roff, Peter The Washington Times (Washington, DC), January 2, 2013 Read preview Overview VIEW ALL RELATED BOOKS AND ARTICLES


text:
Based on 12 guest reviews
Property Location
With a stay at Hotel Ocean in Hualien, you'll be near the beach and minutes from Pine Garden, and close to Beibin Park. This 4-star hotel is within close proximity of Songyuan Villa and Japanese General House.
Make yourself at home in one of the air-conditioned rooms featuring DVD players and LCD televisions. Conveniences include coffee/tea makers and complimentary bottled water.
Rec, Spa, Premium Amenities
Make use of convenient amenities, which include concierge services and tour/ticket assistance.
Business, Other Amenities
Featured amenities include dry cleaning/laundry services and laundry facilities.


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YouTube To Give Viewers Optional Ad-Free Subscription ServiceOn Wednesday, the online video service sent a letter to its most-popular content creators asking them to sign off on new contract terms to allow for the change.
Netflix Goes For Laughs With New Stand-Up SpecialsNetflix is announcing performances by comics, set to roll out this fall...
Netflix Raises Subscription Price $1 Per Month For New SignupsNetflix is raising its Internet video prices by $1 per month for new customers and giving its current U.S. subscribers a two-year break from the higher rates.
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KCBS Sports Fans: Big Money Dodgers Facing Slumping TV AudienceMuch of the attention the Los Angeles Dodgers have been getting focuses on their drunken-sailor-level spending. The Dodgers will enter the 2014 season with the biggest payroll in the big leagues at over $220 million. That's $75 million more than the Giants and a staggering $160 million more than the A's.
Beats Music Digital Music Service To Launch In JanuarySpinoff of Beats by Dr. Dre headphones will launch digital music service next month, slightly later than planned...
Netflix Shuffles The TV Deck With Online Series 'House Of Cards'In Netflix's bid for a flagship original drama of its own, the subscription streaming service is presenting a high-class adaptation of a British political thriller…
Facebook To Let Developers Charge SubscriptionsFacebook is letting app developers charge subscription fees, in addition to existing one-time payments, for games and other applications on its site
Netflix Shares Plunge To 20-Month LowNetflix shares on Tuesday plunged to their lowest point in more than 20 months.
Tech Report: Is Netflix Still A Good Option For Streaming?Despite losing 800,000 customers since announcing a price increase in June, is Netflix still a viable option to stream movies and TV shows?
Beyond Netflix: Where Else To Get Your Flick FixEven with a fee hike, Netflix subscribers will be spending less each month than what it costs two adults to watch a single movie in a theater...


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Obama all the way in 2012.
Deke, are you afraid of the audit that will be done on the TEE Center parking deck?To be honest, and I have tried to be impartial about...
Keep up the good work, Chester.The improvements are great for the urban area.
Giants 31-24 over New England.
I went to kindergarten there in 1937 and played on the playground many days. I also attended many basketball games in the old gym during...


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Mathematically Modeling Eddy Shedding
COAPS oceanographer, Dmitry Dukovskoy, is helping educators teach students about the process used to mathematically model eddy shedding in the Gulf of Mexico. Watch video >>
Evaluating climate and Earth System Models and derived projections
COAPS, in collaboration with the Atlantic Oceanographic and Meteorological Laboratory/NOAA, is working to demonstrate better diagnostics for understanding meridional circulation, according to Dr. Xiaobiao Xu.
COAPS student awarded NASA Earth & Space Science Fellowship
Congratulations to Danielle Groenen, a PhD student in Meteorology selected for a NASA fellowship for her application entitled "Mid-Summer Droughts Amidst Landfalling Tropical Cyclones and Atmospheric Rivers." Learn about NESSF>>
Tallahassee Weather
Dewpoint: ° F (° C)
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Altimeter: in Hg
Hurricane Activity
The Atlantic graphical tropical weather outlook is updated at approximately 2am, 8am, 2pm, and 8pm EDT from June 1 to November 30 by the National Hurricane Center.
Statistical Prediction of Integrated Kinetic Energy in North Atlantic Tropical Cyclones. Monthly Weather Review.
Thirty-two-year ocean–atmosphere coupled downscaling of global reanalysis over the Intra-American Seas. Climate Dynamics.
How Well Do Global Climate Models Simulate the Variability of Atlantic Tropical Cyclones Associated with ENSO?. Journal of Climate.
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Founded in 2005, ArchitectMade is a Danish company that celebrates the products designed by legendary Danish architects. Creating replicas of the original iconic designs, ArchitectMade features items designed by Poul Kjærholm, Jørn Utzon, Finn Johl, Kristian Vedel, and Hans Bølling, among others. The company works with living artists directly, or works with the families or foundations of design greats to secure the rights to issue or reissue their designs. The product assortment includes midcentury icons and never before seen items from Denmark's most celebrated architects.
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JACKSON, Mississippi — Mississippi's unemployment rate fell to 7.5 percent in April, as more people found jobs despite a falling labor force. A separate survey showed employers added 5,000 people to their payrolls in April, reversing four months of declines. Both sets of figures — adjusted to cancel out seasonal changes — were released Friday by the U.S. Labor Department. ...Read More »
Tag Archives: unemployment
MDES: Unemployment Insurance available to storm victims
JACKSON — Anyone temporarily or permanently unemployed as a result of this week's storms may apply for Unemployment Insurance benefits on the Mississippi Department of Employment Security's website at mdes.ms.gov. Each claim will be verified using regular processes to determine individual eligibility. All WIN Job Centers are open and computers are available for individuals to use for filing UI claims ...Read More »
State's unemployment rate falls slightly to 7.4 percent
ACROSS MISSISSIPPI — Mississippi's unemployment rate ticked down to 7.4 percent in January, as a few more people found jobs. A separate survey shows state employer payrolls falling slightly. Both sets of figures — adjusted to cancel out normal seasonal changes — were released yesterday by the Mississippi Department of Employment Security. It's the lowest state jobless rate since October ...Read More »
State's unemployment rate falls with labor force losses
ACROSS MISSISSIPPI — Mississippi's unemployment rate fell to 8 percent in December, as people continued to drop out of the labor force. A separate survey showed state employer payrolls rising slowly, painting an overall picture of a state economy slowly continuing to improve, but still lagging the national recovery. Both sets of figures — adjusted to cancel out normal seasonal ...Read More »
Bryant's State of the State focuses on jobs, education
JACKSON — Gov. Phil Bryant presented a generally optimistic outlook about Mississippi during his State of the State address, focusing on job creation and saying he believes the state can improve its academic performance with charter schools and merit pay for teachers. Republican Bryant, who's beginning his third year as governor, said he wants to hire more Highway Patrol troopers, ...Read More »
Heritage Home closing furniture plants
SALTILLO — Heritage Home Group, LLC said yesterday that it will close furniture plants in Saltillo and Thomasville, N.C., as part of a post-bankruptcy restructuring. Heritage told the Mississippi Department of Employment Security that it would cut 480 jobs in Saltillo by March 21. The plant near Tupelo makes upholstered reclining furniture under the Lane name. Heritage told the North ...Read More »
Cochran issues statement on unemployment benefits standoff
WASHINGTON, D.C. – U.S. Sen. Thad Cochran (R-Miss.) has issued a statement regarding the latest series of votes regarding Senate legislation to extend jobless benefits to the long-term unemployed. "The economy posted its weakest job growth in three years and all Senators should have an opportunity to fully debate and vote on ideas that could help put more Americans to ...Read More »
Pharmaceutical maker lays off workers; could owe state money
DEKALB — A Kemper County drug maker has laid off about 75 employees, leaving questions about its future and whether it has to repay economic development money. Pharma Pac LLC made the layoffs Dec. 19, according to a notice filed with the Mississippi Department of Employment Security. Kemper County Economic Development Authority Executive Director Craig Hitt said the DeKalb company ...Read More »
WHAT'S NEXT? Community concerned about Viking Range layoffs
GREENWOOD — Viking Range Corp. has had another round of layoffs, including some in management, in a move that took Greenwood officials and residents by surprise. The Greenwood Commonwealth reports that estimates for the latest layoffs ranged from 25 to 75. Attempts to reach representatives of The Middleby Corp., a Chicago-based company which bought Viking at the end of last ...Read More »
Tupelo hospital lays off more than 100 workers
TUPELO — North Mississippi Health Services in Tupelo has laid off 109 employees. A statement from a NMHS says the cuts are across the board. The hospital has declined to give specific numbers or positions being eliminated. Chief medical officer Dr. Mark Williams says the reductions were prompted by the ongoing shift from inpatient to outpatient care, declining government reimbursements ...Read More »


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New Samsung Gear VR headset due in November
Samsung will release its first consumer version of its Gear VR headset in November. This new version will first go on sale in the U.S. and will cost $99. Samsung says that the headset will be available...
Samsung`s S Health now free for all Android users
S Health is a suite of fitness stuff from Samsung which has always been limited to their own devices. Until now. From today, any Android user can avail of the goodness of S Health, which is mostly about...
Samsung`s S Health available on non-Galaxy Android phones
Android users who don't own a Galaxy device can now grab Samsung's S Health app from the Google Play Store for free. The app to date has only been available on Galaxy handsets, and is pre-loaded...
Galaxy S7 expected to be Samsung`s toughest handset
While Samsung's Galaxy S7 isn't expected to arrive until March of next year, the rumour mill is already working away. The Galaxy S7 is expected to be made of tough stuff if new reports are...
Samsung to release foldable smartphone next year
Samsung will apparently release the world's first foldable smartphone next year. It's rumoured that it may be available as soon as January 2016. Samsung's Project Valley is reportedly...
Samsung may release world`s first foldable smartphone in January
Samsung is reportedly working on a foldable smartphone, which could be available as early as January 2016. The smartphone is codenamed Project Valley and is said to be under testing at present. There...
Samsung and Sony take pot shots at Apple after iPhone 6S and iPad Pro announcement
Apple unveiled the iPhone 6S and iPhone 6S Plus yesterday, but not everyone was convinced. Rivals Samsung and Sony made sure they got some licks in too. Samsung didn't seem too pleased that Apple...
Two Samsung Galaxy S7 models reportedly in development
With the announcement of the iPhone 6S out of the way, it was only a matter of time until we heard about what Samsung has in store. It didn't take as long as many might have thought to hear about...
Huawei may be working on double-edged smartphone
Huawei looks to be taking a leaf out of Samsung's book by working on a smartphone with a double-edged curved AMOLED smartphone. And it's reportedly getting assistance from Samsung too. The...
Samsung Galaxy S7 might come in two sizes
With the iPhone 6S announced, it was only a matter of time until we heard rumblings about Samsung's next flagship. It didn't take long; a rumour from Asia Today suggests that the Galaxy S7...
Samsung announces new RAM chip – 6GB flagships expected in the future
Samsung announced that it has started mass production of 12Gb LPDDR4 RAM chips based on its 20-nanometer process technology. This, it says, will lead to the creation of flagship smartphones with 6GB RAM. This...
Samsungs Gear S2 finally works with other phones
Samsung didn't have any new phones to show off at IFA this year but they did bring some funky smarthome products as well as their brand new Gear S2 smartwatch. The company hasn't had...
Samsung releasing first Ultra HD blu-ray player
Samsung wants to bring you really, really high resolution home viewing. At IFA 2015, the tech giant unveiled details for the launch of the first Ultra HD blu-ray player. This device will bring 4K video...
VIDEO Watch Samsung`s IFA 2015 press conference
IFA 2015 is rocking on as we speak, with the major manufacturers jumping the gun by holding their own press conferences ahead of the September 4th start date. The latest is tech giant Samsung which wasn't...
Samsung brings Internet of Things to IFA 2015
IFA 2015 is about to kick off in Berlin and Samsung is going big with some unusual products. It seems the tech giant wants to get into the Internet of Things space. This term refers to connected devices...
Here`s the slick new Samsung Gear S2
Smartwatches are here - actually they've been here for quite a while but the arrival of the Apple Watch has seen interest in these wrist-worm devices increase over the last few months. Samsung is...
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Alaska Budget Motel
No prices found through our partners. Please contact the business directly or check some of our recommended alternatives.
TripAdvisor Reviews Alaska Budget Motel Anchorage
Travel Blogs from Anchorage
Rainy Day in Anchorage
... for me and Quinn) it wasn't open. Instead we headed over to the brand new trampoline park (it opened this week). The boys were in heaven and spent a few hours doing flips, playing basketball and dodgeball on a trampoline court and trying the Ninja Obstacle Course. It is a really cool, fun place for kids. Before we came up, Steve had read about this new burger truck, Everybody Loves a Quickie, ( http://www.adn.com/article/20150708/din ...
In, over, and out of Anchorage!
... with 20+ hours of sunlight. Were the soil better, Alaska could indeed be the nation's breadbasket! But the gritty soil is good for a limited number of plants. But flowers lead the list!
I loved the friendly streets of this town and the stores were crowded with tourists, as two ships were in port. With all the crowded stores and demanding patrons, the sales people maintained their cool and politeness.
Like a ...
... I didn't expect to see much but the fishermen were there wading out through the silt flats into the river. There were dozens of them, if not 100+ all lined up along the river on both sides. They fish without bait and continually flick the weighted hook out and drag it back in trying to 'snag' the salmon swimming along the bottom. I saw plenty of fish caught, some as big as 6-8lb maybe even 10lb.
Thursday 17/6 - Flying to LA today
San Francisco to Anchorage
... become integrated into the community again and choose to live the way they do because they don't need to answer to anyone. Plus the weather is so good that San Fran attracts them from all over the USA. She said it's hard to help people who don't want to help themselves. We noticed a lot of them are disabled or suffering from mental illness. We have the same problems in Sydney but San Fran really seems to have more than its fair share. Very sad to ...
Day One-Anchorage
... it was super cool. Leave it up to our family to take a mini van off roading. Ha! We saw gold prospectors panning, old mines, beautiful rivers, and three moose, prairie dogs, glaciers, and hiked. The flowers and vegetation were gorgeous. The views were postcard perfect! After returning to Anchorage for a little shopping and strolling downtown, Austin finally got some time in the hotel pool before heading out to dinner at The ...
Other places to stay in Anchorage
Ramada AnchorageDowntown, Anchorage | 3 star motelfrom $92
Anchorage Super 8 MotelSpenard, Anchorage | 1 star motelfrom $131
Motel 6 Anchorage MidtownMidtown, Anchorage | 1 star motelfrom $145
Anchorage Suite LodgeNorth Star, Anchorage | Motelfrom $115
Inlet Inn MotelDowntown, Anchorage | 1 star motelfrom $40
Royal Suite LodgeSpenard, Anchorage | Motelfrom $75
Red Roof Inn Anchorage1104 E Fifth Ave, Anchorage | 1 star motelfrom $63
Black Angus InnNorth Star, Anchorage | Motelfrom $55
America's Best Inn & Suites - Anchorage Eagles NestSpenard, Anchorage | 2 star motelfrom $122
Mush Inn MotelMountain View, Anchorage | 2 star motelfrom $54
Econo InnDowntown, Anchorage | 1 star motelfrom $88
Travelodge AnchorageDowntown, Anchorage | 2 star motelfrom $75
Creekwood InnNorth Star, Anchorage | 1 star motelfrom $128
Lakeshore Motor InnBayshore / Klatt, Anchorage | Motelfrom $121


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Over the Hill Gang going strong
A group of men age 60 ? 91 meets three times a week to play baseball. Calling themselves the 'Over The Hill Gang,' they admit their play isn't as fast as it once was, but they have just as much fun. Videojournalist: Johnny Milano (Aug. 21, 2103)
Newsday.com now uses Facebook for our comment boards. Please read our guidelines and connect your Facebook account to comment.
Under the helmet: Inside LI football helmets Former president's son's home for sale in Woodbury 3 injured in police patrol car crash Crash closes Sunrise Highway in East Patchogue Off-duty Suffolk County officer helps revive hockey player North Amityville gas station attendant robbed, say cops One dead after bar dispute 'Blessing of the Animals' in Brentwood Making apple cider in Northport Tom Cutinella anniversary vigil on football field Coastal concerns for Fire Island as Joaquin nears Forecast: Coastal flooding likely as rain pelts LI


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Credits & Info
- Uploaded
- Aug 21, 2006 | 2:57 PM EDT
- Daily Feature August 22, 2006
If you liked this, check these out!
Plenty more like this here!
Author Comments
Rated 5 / 5 stars
Good game!!!
Whoohoo.. That was just like the real Super Smash Bros. Melee! Good job!
Rated 4 / 5 stars
it was quite a good game
good game overall nice graphics
Rated 5 / 5 stars
It is loved by me
A perfect game. Good work!
Rated 4.5 / 5 stars
SSB in computer form..
This is a great game. I like the whole copy off of SSB, but if you could make an original game next I know it would be awesome.
Any original game would be cake, I'll just make a "fun-to-play-once-then-it-get s-boring-clicking-game".
Ha, or at least that's what a lot of games are like. I actually have written a lot of RPG's but sadly they are in a BASIC language for your TI-83 Plus calculator. I may make some of them in Flash later, I'm sure you'll enjoy them.
Rated 4 / 5 stars
the only thing that needs improving is the screen as when player 1 goes away from player 2 the camera only concentrates on him and player 2 cannot see and may fall off screen.


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Omg the tangles!
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Join Date: Aug 2011
Posts: 571
Thursday, September 20, 2012 at 07:52PM
You have got me so curious!
When is the last time you used protein in your hair?
It does seem like your hair is
porous. I started to think this when you said it was slurping up KCKT...and then GVP Balm...But then when you said it drank in mayo, eggs, etc. ...WOW. (It's hungry too!
Even with a "Prell" wash, I cannot imagine non-porous hair being
absorbent. When is the last time you did a "floaty" test?
If your hair was coated with cones, I don't think it would be able to suck in all that stuff. I think your hair would feel sticky; not to mention phenomenally greasy.
Do you color your hair? (I can't remember what you said about this, sorry)
Did you have your hair analyzed very recently?
Could it possibly be your water stripping every last bit of moisture from your scalp? I moved to AZ from SoCAL last June, and the difference in the water is remarkable. Whenever I hear anyone in AZ complaining about the "hard" water, I know for sure they've never lived in LA. The water back there feels like rinsing with sand compared to the water here, and I don't have a water softener. At some point, could your hair have been absorbing too much water, and the heaviness led to trouble?
3b/c, Coarse, Low Porosity, Desert Climate
CG since August 2011/Occasionally Modified since 2013
: Wen Cleansing Conditioner/Coconut Lime Verbena, KC Come Clean, KCKT, Pure Argan Oil, Pure Coconut Oil,
Eco Natural Curling Cocktail, Desert Essence Hair Defrizzer and Heat Protector ECO gels


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Click here to print the obituary below
Robert Frank Pencek
Robert Frank Pencek
AGE: 70 • Fair Hill, MD
Robert Frank Pencek, 70, of Fair Hill, MD., passed away on Thursday, March 20, 2014 at his residence. Rob was born May 4, 1943 in Brooklyn, NY.
He was the beloved husband of Kathleen (Mele) Pencek and the son of the late Adolph and Thelma Pencek. In addition to his wife, he is survived by his sister, Jeanette Biddle (Bob), sister-in-law, Carolyn McCorquodale (David), brothers-in-law, Michael A. Mele, Jr. (Suzannah), Robert Mele (Barbara), nieces and nephews, Jenny (Biddle) McGee, Kenneth Biddle, John Biddle, Kelly (Biddle) Burton, David M. McCorquodale, Matthew McCorquodale, Suzanne (McCorquodale) McKenzie and Michael A. Mele, III. He is also survived by his cousins and many friends. Rob was preceded in death by his son, Robert F. Pencek, II in 2011.
Rob graduated from Bohemia Manor High School in Chesapeake City, MD., and later attended the University of Delaware. Drafted in 1966 into the U.S. Army during the Vietnam War Era, Rob trained as a radio signalman. He married his sweetheart, Kathleen, on May 12, 1978. Rob was employed by
General Motors
, working in the body shop in quality control, retiring after 31 years. Along with his wife, Rob also owned and operated a successful motel business in Wildwood Crest, NJ., for 16 years. Having grown up along the Elk River in Port Herman, MD., Rob loved fishing and boating. He especially enjoyed playing cowboys and Indians and watching western movies with his cousins on the farm at Aunt Helen's. Rob loved Aunt Helen's galumpkies and lemon meringue pies. He also enjoyed going out for milk shakes and malts with his dad. Born with artistic talent, he enjoyed drawing cartoons. Rob loved animals, especially his dogs, Brandy and Sheila. Rob enjoyed spending winters in sunny Florida and liked going to auctions to look for that perfect treasure.
Rob loved cruising in his classic cars and on his motorcycles. He absolutely loved car shows, pointing out to his wife the make and model of the cars and all the engine types and parts. Listening to music, especially the oldies of the 50s and 60s was a favorite pastime of Rob's.
Most of all, Rob particularly loved watching ballgames and playing basketball with his best buddy, his son, Robert. Rob attended Grace Bible Chapel and enjoyed singing the old classic hymns that he sang as a child at Town Point Methodist Church in Port Herman.
With a fun-loving personality, Rob could be zany and silly at times, making funny faces or suddenly bursting into song, but he could also be quiet and pensive - he loved listening to the sound of rain on the roof on a summer afternoon or the thunderous roar of the ocean waves.
Rob will be remembered as a loving husband, father, devoted uncle and friend. To Rob, there were no strangers, only friends he had not yet met. He treasured his friends, giving hugs liberally. Our hearts are broken as we mourn Rob's passing; he will remain in our hearts forever. We will remember his beautiful smile, his loving personality, and his heart of gold.
A celebration of Rob's life will be held at 11:00 am Thursday, March 27, 2014 at Grace Bible Chapel, 1949 Biggs HWY, Rising Sun, MD., where family and friends may arrive beginning at 10:30 am. Burial will follow at Sharps Cemetery. Memorial contributions may be made payable to Union Hospital of Cecil County or to the Robert F. Pencek, II memorial fund at Grace Bible Chapel and sent in care to R.T. Foard Funeral Home, P.A., 111 S. Queen St., Rising Sun, MD 21911. To send condolences, please visit
R.T. Foard
Funeral Home, P.A.
Funeral Directors
& Crematory
(410) 658-6030
A Life Celebration® Home
Funeral Home
R T Foard Funeral Home Pa
111 S Queen Street
Rising Sun, MD 21911
Published in The News Journal on Mar. 24, 2014


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Sydney BridgeClimb
- Climb Sydney Harbour Bridge with an experienced guide
- Admire spectacular views of Sydney Harbour, the Sydney Opera House, the Blue Mountains and more
- Follow a professional guide who ensures a safe, fun and informative climb
- Choose from a number of departure times for the 3.5-hour tour
- Have the option to take a more rigorous 2.5-hour Express Climb
- Try a 1.5-hour Sampler Climb if you have limited time or concerns about heights
- Each climb includes a maximum of to 12-14 people, providing a more personalized experience
Why Our Insiders Chose This Tour
Adventurous locals and visitors alike have flocked to BridgeClimb since it opened, with thousands of marriage proposals and birthdays celebrated here. Among the informative displays in the Visitor's Center, check out photographs of celebrities who have climbed the bridge.
Recent Photos of This Tour
On top of the World, or at ...Photo by: Stephen P
05 2015
Coming back down from bridge ...Photo by: Gregory H
09 2014
G'day mate!Photo by: Thomas W
04 2014
The Sydney BridgePhoto by: Paul B
10 2015
We did it ! Why dont you. ...Photo by: Cheryl R
Australia, 09 2015
Sydney Bridge ClimbPhoto by: Lucy
United Kingdom, 08 2015
On top of the world!Photo by: Martin J
08 2015
Great city view at the topPhoto by: jjfisher406
08 2015
Another item ticked off the ...Photo by: Anne H
06 2015
After the ClimbPhoto by: Michael G
05 2015
My shot from the BridgePhoto by: Clay S
So scary it's funPhoto by: Laura
02 2015
We did it!!Photo by: Eric C
01 2015
Fabulous Bridge ClimbPhoto by: Harold M
01 2015
Sydney View from the PylonPhoto by: Anonymous
12 2014
Sydney View from the PylonPhoto by: Anonymous
12 2014
Sydney View from the PylonPhoto by: Anonymous
12 2014
Sydney View from the PylonPhoto by: Anonymous
12 2014
Sydney View from the PylonPhoto by: Anonymous
12 2014
Sydney View from the PylonPhoto by: Anonymous
12 2014
What You Can Expect
When you're ready, follow your expert Climb Leader through a purpose-built tunnel that leads to the bridge. Securely clipped into a safety wire, start to climb the steady incline up the arches of the bridge, traversing catwalks and ladders all the way to the 440-foot (134-meter) summit. At the top, stop to admire panoramic views of Sydney and its surroundings. To the east you can see the sails of the Sydney Opera House and to the west the majestic Blue Mountains are visible in the distance (on a clear day).
Throughout your tour, you can hear your guide via provided headsets. Listen to informative commentary and fun stories about the history of Sydney and the bridge and receive plenty of encouragement during your climb. Your guide stops at scenic points along the way so that you can take in the sights.
The 3.5-hour BridgeClimb is suitable for people with a moderate level of fitness. The 2.5-hour Express Climb proceeds at a faster pace with fewer stops. The 1.5-hour Sampler Climb goes to a halfway point inside the inner arch before returning to the ground.
After all tours, receive a complimentary group photo, commemorative certificate and BridgeClimb cap. Please see more details about each tour under Itinerary below.
This is the original climb that takes the outer archways to the summit. Choose from a morning or afternoon departure and see the city in full swing.
The Dawn Climb (3.5 hours):
Take in the breathtaking views of the sun rising over Sydney on a dawn BridgeClimb. Join the first group to climb the Sydney Harbour Bridge for the day, departing in the early morning before sunrise. Exact departure time is determined by timing of the sunrise. Receive two additional complimentary photos on this tour.
Twilight Sydney BridgeClimb (3.5 hours):
Get the best of both day and night on this tour, which departs just before sundown. Take in a spectacular sunset and watch the moon and stars appear during your climb. Exact departure time depends on the timing of the sunset.
Night Sydney BridgeClimb (3.5 hours):
Depart after the sun has set on this 3.5-hour tour to the summit. See the sparkling lights of the city and harbour below while the stars and moon shimmer above.
Express Climb (2.25 hours):
If you don't have a lot of time or simply prefer a faster route to the summit, the Express Climb provides an incredible experience in a group of no more than 12 people. Unlike the longer tour that walks along the outer arches, your route goes through the heart of the structure, which provides a different perspective. With this option, there are fewer steps to climb, fewer stops and the ascent to the top moves at a faster pace. Perfect for those with a higher level of fitness who are looking for an energetic experience within a shorter time frame.
BridgeClimb Sampler (1.5 hours):
The Sampler is ideal if you have limited time, would like a more economical option or have concerns about heights and prefer not to go to the very top. The climb follows walkways on the inner parts of the bridge, which some people prefer to the exterior walkways used for other climbs. Reach a spectacular vantage point located on the inner arch of the bridge at the highest point of this climb, which is situated about halfway to the top of the bridge. With a maximum of 12 people, you're sure to have customized attention from your expert guide.
The VIVID Climb:
Experience the magic of a bird's eye view of the city as it sparkles during VIVID Sydney 2015. Get spectacular views of the colorful light installations all around the harbor and as you climb the bridge. You'll also take part in the Sydney Harbour Bridge light show when you wear the provided VIVID Climb Vest. You will climb into the frame of a unique festival installation, high above the city, to capture the must-have image to commemorate your VIVID climb. The VIVID Climb will only be available during VIVID Sydney 2015 (May 22 – June 8).
Mandarin Climb (3.5 hours):
Take the 3.5-hour BridgeClimb with an expert guide who speaks Mandarin fluently.
Customer Reviews
October 2015
So much fun! A must do.
October 2015
What an awesome way to spend a few hours in Sydney.
I love doing the climb it is everything and more.
September 2015
Absolutely amazing, well organized - Steff tour guide brilliant full of knowledge and laughs. Absolutely recommend the twilight tour.
September 2015
I couldn't recommend this tour more. Our BridgeClimb guide was awesome. So fun. We did the night climb, and it was amazing. If you visit Sydney for more than one day, I feel like you have to do this. Highly recommended.
September 2015
This was absolutely fantastic, well worth doing the views are stunning very glad I did it
September 2015
Very well organised and very much with safety in mind trip, a must do in Sydney
September 2015
I am afraid of heights. but wanted to do this with my daughter. I felt comfortable the entire time, and was so surprised. The climb is well run, and the staff works to make you feel confident. I am so glad I did this and would have regretted if I missed out.
Cheryl R
September 2015
Michael and l went on the night climb. here is lots of preperation that you go through before you start climbing which was really good as when you used it on the climb it wasn't so scary. We started our climb just before the sun set so got the best of both worlds. Pure magical is how we would describe it. The history of ther bridge was fasinating and unless you are in a hurry in which l suggest you do the express climb it was lovely having stops along the way being filled in woth history and most of all admiring the beutiful views from differant angles. I am scared of heights but once l was suited up l left my fear behind and not once did l feel scared. Our climber/guide was awesome as were all the staff. There are drink fountains along the way. Everythng was catered for including jackets if cold etc. I would recommend this climb to anyone. We didn't feel it expensive when you think some people can put that through the pokies or waste on alcohol/smokes. Climbing the bridge will always be embeded in our memory. Was totally amazing.
September 2015
This IS a MUST. Jes, our guide, was so knowledgeable and fun that all anxieties just disappeared! Can't beat the views.
September 2015
Well worth the money. Well organised. Guide was friendly and knowledgable. Unforgettable experience.


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Obituary & Guest Book Preview for Laura R. Patterson
Laura R. Patterson Obituary
Published in Belleville News-Democrat on Sept. 20, 2012
First 25 of 280 words
: Laura Patterson Laura Ruth Patterson, 87, of Columbia, Ill., born July 29, 1925, in Festus, Mo., passed away Tuesday, Sept. 18, 2012. Mrs. Patterson was...
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