text:
Rapha launch spring/summer 2013 clothing range +videos
New women's and hot weather clothing, trade team specials and updated classics
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It's already been a busy year for Rapha, kicking the year off with the announcement of the Team Sky partnership thrusting them into the spotlight of the professional peloton. Today they've revealed details of their 2013 spring/summer racing and training range. Highlights include some bold new colours, an expanded women's range and new hot weather clothing and all accompanied by some suitably 'epic' videos (scroll to the end for them).
With three new jerseys Rapha is marking the year, 1962, when trade teams returned to the Tour de France and roadcc's editor was born though that bit probably isn't part of the Rapha celebration - well, not officially at least. From 1930 until 1961 only national teams could compete in the race - in 1930 organisers even made riders compete using identical yellow bicycles supplied by them. In 1962 though the trade teams were allowed back in and that race Jacques Anquetil claimed the yellow jersey, with Joseph Planckaert and Raymond Poulidor second and third respectively.
These three Trade Team Jerseys (£110) celebrate each of these riders and their teams, Flandria & Planckaert (red and white), Mercier & Poulidor (yellow and purple) and St Raphaël & Anquetil (Light blue, white and red).
The three merino jerseys are finished with embroidered icons , drawcord hems and gripper elastic and three pockets.
There's also matching caps as well for the complete look. They feature rider emblem graphics and are made from 100% cotton.
The new Hot Weather collection, clearly not designed with the UK summer in mind, is designed for the "hottest, most humid climates" proclaims the Rapha press release. Guess if you're planning some nice trips abroad this year you might be interested, we can certainly imagine some of the demands from Team Sky will be kit that works in the hottest races. In this new collection are two items, the Lightweight Bib Shorts and Super Lightweight jersey. As their names suggest, they're based on the regular Classic Bib Shorts and Lightweight jersey, but boast better breathability when the going gets, errm, hot.
The Super Lightweight jersey (£100) is made from a combination of three lightweight fabrics.
They reckon is a lot more breathable than the regular Lightweight jersey, and very good at wicking sweat. It's going to be available in three colours, blue, red and white.
The Lightweight Bib Shorts (£140) that uses a much lighter weight fabric than the Classic bibs and the fabric has been treated with a sun-block finish giving up to Factor 50 protection. The mesh sections in the jersey lighter than before and there's a larger cutaway at the back. Inside the shorts is a totally new chamois exclusive to Rapha. To prevent the pad getting soaked in sweat, it has a perforated construction, which also makes it lighter.
They're finished with a left leg band available in red, blue or white.
To complete the Hot Collection there's a new Lightweight cap. A quick drying poly cotton with stitched eyelets and available in blue, black and white.
There's new offerings for women, as well as new colour options for the Wind Jacket (£170), purple and red, and a choice of purple, cream or grey and hi-vis pink Lightweight Jerseys (£110), they've introduced the all-new Soupless Jersey and Women's Classic Bib Shorts.
The Souplesse Jersey (£125) has been designed from the outset to address the differences between men and women with a female-specific cut, including shorter sleeves and separate cuff fabric for a comfortable fit.
There's two rear pockets and a central pump pocket, plus a zipped pocket. There's contrast stripes and polka dot collar linings. Three colours to choose from, mauve, dark blue or light blue.
The same approach has been applied to the new Women's Classic Bib Shorts (£150). The men's Classic bib shorts are excellent and perfect for comfort on longer rides, and a similar approach has been applied to the women's version. they have a fit designed specifically for women of course, with a soft mesh upper with a full-length zip front. The back panel is an open-knit mesh for maximum breathability and the lightweight fabric is extremely breathable.
The Women's Classic Wind Jacket (£170), follows similar lines to the men's version, with a windproof and water resistant fabric, but with a cut tailored for women. It's available in Purple, Cream and Red.
We always expect Rapha to have something a little quirky up their merino sleeves, and this year it would seem the Polka Dot Silk Scarf (£50) is it - the polks dots are the quirky bit, the scarf itself is a hardy Rapha perennial - we reviewed it a few years back. It's hand stitched in England from 100% silk, and the material has been treated to make it sweat and shower resistant.
There's a new short sleeve women's base layer (£60) as well, made from 100% merino, naturally, and with a female-specific cut. Available in light blue or grey marl, with a v-neck and flatlock seams.
The Women's Grand Tour Gloves are a leather thing of beauty. Handcut from African Hair Sheep Leather, they're stunningly beautiful as much as the price is eye-watering. Double-stitched in the areas prone to high wear to make them more durable. Choose from black or cream, available in March.
A new colour option is added to the Classic Wind Jacket (£170), their lightweight stowable windproof and water resistant top.
It's now available in the same Chartreuse as the Hardshell we tested recently, and there's an orange and black colours too. It still feature the same offset zip, long dropped tail and small zipped pocket.
The Classic Jersey (£130) has been Rapha's best selling product and was one of the iconic jerseys, all black design with simple white arm band, that launched the brand eight years ago. It's been constantly fettled and tweaked over the years, and many colour options have come and gone.
This year they've refined the fit even further and will offer it in two new colours (red and blue) with corresponding arm warmers and Rapha Caps to match. Details include large cargo pockets and a zipped valuables pocket, a fully lined zip with lockdown puller and is sold with arm warmers.
The Rapha Cap (£25) is now available in corresponding red and blue to match the Classic Jersey. A windproof and water resistance cotton construction protects the head while still being breathable, and it's finished with a strip of anti-bacterial tape.
The Club jersey (£110) picks three heroes of the sport Tommy Godwin, Ramon Hoyos and Gastone Nencini for the three new colour options, fig, light blue and black respectively.
The Lightweight jersey (£110), a classic choice for riding anywhere hot and sunny, is now available in two new colours, fig and papyrus
The Pro Team range hasn't been ignored, there's the all-new Pro Team Race Cape. Rapha now get a lot of feedback from Team Sky and the Rapha Condor JLT team, and they're channeling this into revised Pro Team garments. The Race Cape came out of just such a discussion, it uses a proprietary stretch fabric that is completely waterproof and claims to be breathable. It also interestingly eschews the usual off-set zip in favour of a simple centrally aligned zipper. It's not due until mid-March, and will be sold in grey or blue.
The Pro Team Bib Shorts (£170) use a new Lyrca-based fabric that is proprietary to Rapha. It uses a coldblack technology to keep the heat off and are now available in high-vis pink and chartreuse.
You can pair those shorts with the updated Pro Team Jersey, now available in Grey/high-vis pink, Chartreuse/grey, White/azure, Black/chartreuse.
No word on pricing yet, they'll be available in mid-March.
The Pro Team socks (£15) are now available in High-vis pink and Chartreuse.
And now for some video… a woman nearly smiles in the first one:
posted by gazpacho [94 posts]
27th February 2013 - 16:04
I like Rapha stuff. I wish it was cheaper and I wish they did more regular sales one their products. It seems there are a lot of jealous types out there (who Blanche at the price). But we all place a value on things depending on our own life demands. I can understand that. If I won the lottery tomorrow I'd certainly upgrade my kit and bike.
posted by Colin Peyresourde [1620 posts]
27th February 2013 - 16:14
posted by boardmanrider [83 posts]
27th February 2013 - 16:17
Why are Rapha-lovers pissing and moaning about Rapha-haters pissing and moaning about the prices. It is a free country, if you don't want to hear others ridiculing the way you spend your money, then move to Beverly Hills, chum, or any of the parts of Cheshire, Essex or Surrey that aspire to a similar ethos, and savour the conspicuous consumption. What, can't afford that? Well too bad, it's called choice. Other places to live are available, you know, and at different prices.
Of course, in reality, the rich have driven house process up for everyone in recent decades, as they are now for cycling equipment and clothing.
posted by ubercurmudgeon [170 posts]
27th February 2013 - 16:21
Sweet lord! Why is it that Rapha gets such a hard time over their prices? Their kit, of which I have several pieces, is seriously high quality in terms of fit, attention to detail and style.
I'll draw the following parallels - nobody gives about the price of any of the deep rim carbon wheelsets you see around. Nobody gives out about the price of high end .
2nd that boardmanrider 'Assos - Castelli'!!
All expensive kit but no one ever queries their quality, price yeah.. but once you actually purchase one of their items you never question it again because you see the difference. Rapha/Assos/Castelli they just do not compare to DHB or whoever - do what i do buy their winter gear in summer & vice versa - you'll see what the fuss is about & save your pennies for better standard gear
posted by bfslxo [155 posts]
27th February 2013 - 16:26
MAMILS are ruining the clothing market, too much money to splurge, just save up for a Ferrari and get out of the way.
You must be really fast then…
Does the 76 in your name refer to your date of birth? Do you wear lycra? MAMILs eh?
I haven't got any Rapha kit btw, but I do have some Castelli stuff which cost considerably more than the equivalent Rapha item, and which is made in China, but they never seem to get any grief about how much it costs or where it's made or who wears it, nor Assoss - not that you ever see any reviews - but then I suppose that's what 'proper' riders like bikeboy76 wear
posted by Denzil Dexter [141 posts]
27th February 2013 - 16:29
The other bit that justs make me laugh is how Rapha are always brought up on how their stuff is made in China, evil vindictive company that they are. Then go an hop on their bike which is made (unless it's a custom made) in China or Taiwan along with the comouter they used to type the rant.
posted by boardmanrider [83 posts]
27th February 2013 - 16:55
Of course, in reality, the rich have driven house process up for everyone in recent decades, as they are now for cycling equipment and clothing.
don't agree, at least not on the bike part. the quality and selection of bikes and clothing in the low- to mid-range price points has never been better. they're pushing the higher end, granted. but if you don't want to spend that much, then don't.
posted by Dave Atkinson [7854 posts]
27th February 2013 - 17:19
posted by jimmythecuckoo [1348 posts]
27th February 2013 - 17:30
boardmanrider wrote:Sweet lord! Why is it that Rapha gets such a hard time over their prices? Their kit, of which I have several pieces, is seriously high quality in terms of fit, attention to detail and style.
I'll draw the following parallels - nobody gives about the price of any of the deep rim carbon wheelsets you see around. Nobody gives out about the price of high end .
2nd that boardmanrider 'Assos - Castelli'!!
All expensive kit but no one ever queries their quality, price yeah.. but once you actually purchase one of their items you never question it again because you see the difference. Rapha/Assos/Castelli they just do not compare to DHB or whoever
I disagree I think it is more a case of no one likes to admit they spent big cash on a pup..
I have bought plenty of Rapha kit full price and in the sale that was as good/bad [delete as appropriate] as any other mainstream cycle clothing manufacturer.
I recently had to return two pairs of fixed shorts, both had serious stitching failures. An early jersey that went from black to purple, a recent jersey due to laddering from the seams, a soft-shell due to seams failing… Other stuff I put up with or sold on the Bay.
I can't believe I am just unlucky…
posted by Fixie Girl [125 posts]
27th February 2013 - 17:48
The Claw wrote:DHB for me thanks
post of the day
Kept me entertained.
posted by mingmong [242 posts]
27th February 2013 - 18:46
I love posts about Rapha. Didn't even read this one and skipped straight to the usual comment mud slinging. Wasn't dissappinted either.
posted by mr-andrew [303 posts]
27th February 2013 - 19:00
They are brilliant though. Makes me laugh. Even when the subjects not Rapha they'll be sure to sledgehammer it in.
Haters going to hate.
posted by iL Soigneur [8 posts]
27th February 2013 - 19:16
That was a record though, this time it only took 1 post to start the usual I hate Rapha but love my Aldi bibs, even though the pads in a funny place.
posted by iL Soigneur [8 posts]
27th February 2013 - 19:19
Polka Dot Silk Scarf (£50) Oooooooh lovely!
Get out and ride
posted by davidtcycle [62 posts]
27th February 2013 - 19:33
Love their stuff. I'm still wearing a long sleeve t-shirt I bought in 2008. During winter it gets washed a couple of times a week. And worn nearly every day. Colour still good. It has kept its shape as well. All the stuff I have fits well, better than other brands to be honest. People buy me gift cards. That helps. The kit simply looks smart rather than garish with large logos. I hate logos.
Still smiling politely at a persistently flat chain.
posted by velophilia [39 posts]
27th February 2013 - 20:09
bfslxo wrote:boardmanrider wrote:Sweet lord!
I can't believe I am just unlucky…
Fixie Girl - I think your are just that unlucky!!
Have a jacket by both Assos & Castelli and they are both top notch - in fairness my Rapha extend is a merino vest which has served me perfectly - oh & one of the ordinary winter neck scarfs bought in the sale which has been brillant all through my daily winter commuter.
Mind i think i gotta agree £50 for a polka dot ladies scarf
posted by bfslxo [155 posts]
27th February 2013 - 21:42
I myself am not a huge fan of this seasons colours but i do like the hommage to the past concept.
Remember Rapha's mission is also to celebrate cycling culture and make it the most popular sport in the world.
Its funny how some brands can create such a split in the public. Swap the word Apple for instance with the word Rapha at the start of these posts and you could be on a tech webiste in 2007!
posted by Nzlucas [119 posts]
27th February 2013 - 22:20
Serious question - wonder if there's a reason the women in Rapha's videos wear helmets and the men don't?
(Not to cross the streams of two more obviously polarising issues or anything)
posted by nicstevenson [32 posts]
27th February 2013 - 22:21
There's a pic of a bloke in a helmet near the top of the page. That one who looks like he's trying to eat his energy bar without taking it out of his jersey pocket first.
Noli porcum linguere
posted by captain_slog [310 posts]
27th February 2013 - 22:29
Does the 76 in your name refer to your date of birth? Do you wear lycra? MAMILs eh?
It does in fact, however I claim exemption from the MAMIL tag as I have been riding around since 1999 age 22, so I am a 'young' 36. I have plenty of kit collected over the years, nike, nalini, craft and yes Castelli, but I wait and buy stuff off ebay once it has come down to a reasonable price. A plain Rapha summer jersey will still cost you £65 on ebay so auction competition and the prices are also inflated there.
The point is the mark up doesn't reflect the true quality of the kit even if it is better. Rapha is Waitrose but thinks its Harrods.
posted by bikeboy76 [1812 posts]
27th February 2013 - 23:17
I've used stuff from DHB, Altura, Endura, Shower Pass, Craft, Gore and Ground Effect (favourite) and some random outdoor brands.
Any piece of kit that I don't think about while cycling, that doesn't fall apart after a season or two and that doesn't make me look like a "...spaceman from a low budget Sci-Fi movie..." is good enough in my books. What else would one want from their kit?
Just like with many other products on a market up to a certain price point you're buying quality that makes a difference (better cut, longevity, breathability etc.)
Above that there is only a stratosphere of aspirational BS exploiting anxieties and insecurities (at least cycling wise) of a modern over-analysing OCD consumer.
I don't follow trends. Trends follow me.
posted by BBB [250 posts]
28th February 2013 - 0:20
I like Rapha kit.. It's well made and looks good. BUT! I can't abide the way market the stuff.. Trying to bottle up the essence of cycling heritage and selling it back to us... Ramming it down our throats in black and white ads. No pal.. Not for me thanks..
posted by partsandlabour [33 posts]
28th February 2013 - 0:22
Hell,Road CC- a Rapha and a helmet article on the same day-were the numbers of comments on the site getting a bit too low for your liking...?!
posted by Otis Bragg [170 posts]
28th February 2013 - 0:45
£50 for a silk scarf?
This could get interesting
I guess folk where you live haven't heard nuffin' of this "Hermes" stuff neither.
posted by Nick T [906 posts]
28th February 2013 - 1:04
I wonder if Aldi will be presenting a beautifully lit short film full of earnest hipsters looking solemnly into a sunset with their mouths open when they next announce their cycling Thursday Specials?
posted by Some Fella [908 posts]
28th February 2013 - 1:21
Rapha is Waitrose but thinks its Harrods.
Guess you never saw the Harrods cycling kit in its various iterations? None of them particularly pleasing on the eye...
posted by Simon_MacMichael [9501 posts]
28th February 2013 - 1:31
posted by BearstedCC [76 posts]
28th February 2013 - 8:17
fretters wrote:£50 for a silk scarf?
This could get interesting
I guess folk where you live haven't heard nuffin' of this "Hermes" stuff neither.
course we 'ave. it's like them blister things i got on me bits when i slept wiv 'er from chippy last year. i ain't a total moron
posted by fretters [39 posts]
28th February 2013 - 9:13
I've often wondered the same: this is a pretty good answer.
posted by boardmanrider [83 posts]
28th February 2013 - 10:44


text:
white gold and diamond 'The Carre Collection' earrings
designer's notes
Experience the simple brilliance of extraordinary diamond jewelry from Kwiat with timeless pieces that will last a lifetime.
color: White Gold 18k white gold setting Vertical bar with dangling open diamond pendant Approximate 1.47cttw; GH/VS-SI1 clarity Post backs Measures 1⅜'' long x ⅝'' wide All measurements are approximate 14 Day Return Policy; returns must be received within 14 days. No returns will be accepted on international orders. See FAQ for more details. 18k White Gold / Diamond; U.S.A; style# 320822601

subset: commoncrawl


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November 19: Will California Arbitration Law Survive the U.S. Supreme Court?
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Stephanie Tanner is 32!
"Full House" star Jodie Sweetin celebrated her 32nd birthday on Saturday at Riviera 31 presented by Xperiment USA in Los Angeles.
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Sweetin has a lot to celebrate this year.
The former child star made headlines earlier this month for paying off $53,626.29 in debt to the IRS. So, enjoy those cupcakes, you've earned 'em!
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Stressed? Stretch!
I know the feeling of just being stuck in your desk for a good part of the office day rushing some important reports or business plan. If stress has crept up on you, then you better relax a bit. But you've got not much time, right? How about thirty seconds?
Here's one good stretching exercise I got from a stress management workshop I underwent some time back. Stretching is supposed to keep circulation going. The more oxygen the body gets, the less stressed you'd feel.
- Head for the nearest doorway
- Place you forearms against the door frame
- Slide your right foot forward.
- Now lean your upper body forward slowly. You should feel the stretch in your upper body
- Slide your foot forward a little more (like you're doing lunges). That'd stretch your lower body.
- Now twist your torso to one side. Hold for three seconds. Now twist to the other side.
- Alternate your stance with your left foot and repeat the process.
February 27, 2007 Tuesday at 2:01 am


text:
It Takes a Village to Save an Elephant.
We can start a Community Revolution!
My community is bigger than Boulder, bigger than San Francisco, bigger than America.
Every day, my worldwide community is expanding—and I am enthralled.
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I'm in. Won't you join me?
Incorrect source, offensive, or found a typo? Email us (please put title in subject bar of email so we'll be able to fix). Or do you want to write for Elephant?
{Waylon H. Lewis C Enterprises 2015: Use Rights in perpetuity. Ownership remains with author.}
3 Responses to "It Takes a Village to Save an Elephant."
I agreeeeeeeeeeee!!!! And just like Gandhi said, "A small body of determined spirits fired by an unquenchable faith in their mission can alter the course of history." That is so right! Thank you Rachel, thank you Elephant Journal, I love this community. namaste*
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text:
3D Printer
|3D Printer
|Home | Research & Development | Bill of Materials | Manufacturing Instructions | User's Manual | User Reviews
3D Printers are a subset of CNC machines: they use stepper motors to move along X, Y, and Z axes according to gCode - essentially a text file with thousands of lines of coordinates and special commands (such as "return to origin" or "set nozzle temperature"). As motors on each axis moves the nozzle through 3D space, an additional motor feeds plastic filament through a heating element, very much like an automatic hot glue gun.
The software that turns a 3D model (such as an .stl or .obj) into instructions telling the printer how to move is called a "slicer" - it slices a model into layers that will stack up to make the finished object.
Many options exist for controlling the printer with your computer - nowadays several "slicers" can also connect to the printer directly, streamlining the printing process.. As a central backbone of Digital Fabrication, the end goal of 3D printers is to be able to print anything.
Types of 3D Printers[edit]
Software Options[edit]
Printing Process[edit]
Common Maintenance[edit]
Product Ecology[edit]
See past work related to Factor e Farm at RepRap Build.
Currently 3D printer designs are being researched, with the goal of full integration into the Product Ecology of GVCS technologies.
3D printer technology is currently undergoing a flourishing of innovation. As a relatively new technology (2003), many experimental designs and techniques are being explored by thousands of groups worldwide.
See Also[edit]
- Comparison of 3D Printers
- RepRap Build
- Equipment/Lulzbot_a0_101
- Equipment/Taz
- RepLab
- 3D Ceramic
- Stepper Motor
- MIT Machines that Make
- Electron Beam Melting
- Sintering
- RepRap MetalicaRap subproject, investigating inexpensive, self-replicating electron beam melting machine design for 3D metal object and solar cell printing
- Cermets, materials that may be suitable for 3D ceramic printing techniques but give material properties superior to those of either metals or ceramics
Further reading[edit]


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Showing off some NOS Fisher Stoves.
Post in 'Fisher Stove Information, Parts, History and More' started by Finest Fishers, Mar 4, 2012.
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William Greenleaf is an Assistant Professor in the Genetics Department at Stanford. Efforts in his lab are split between building new tools to leverage the power of high-throughput sequencing and cutting-edge microscopies, and bringing these new technologies to bear against basic biological questions of genomic and epigenomic variation. Will earned his PhD in the Applied Physics Department at Stanford in the lab of Steve Block investigating the single molecule biophysics of transcription. As a postdoctoral fellow in the lab of Sunney Xie in the Chemistry and Chemical Biology Department at Harvard he was awarded a Damon Runyon Cancer Research Fellowship. He started his lab at Stanford in November 2011, and recently was named a Rita Allen Foundation Scholar.
Academic Appointments
Assistant Professor, Genetics
Member, Bio-X
Member, Stanford Cancer Institute
Honors & Awards
Baxter Foundation Faculty Fellow, Baxter Foundation
Rita Allen Scholar, Rita Allen Foundation (2011-)
Damon Runyon Cancer Research Fellowship, Damon Runyon Foundation (2009-2011)
ARCS Fellowship, ARCS (2006)
Gates Cambridge Trust Scholar, Gates Foundation (2002-2003)
Graduate Fellowship, National Science Foundation (2003-2005)
Professional Education
Postdoctoral Fellow, Harvard University, Chemistry and Chemical Biology
PhD, Stanford University, Applied Physics (2008)
Dip Comp Sci, Trinity College, Cambridge University, UK, Computer Science (2003)
AB, Harvard University, Physics (2002)
Current Research and Scholarly Interests
Our lab focuses on developing methods to probe the genome and epigenome at the single-cell and single-molecule levels. Our efforts are split between building new tools to leverage the power of high-throughput sequencing and cutting-edge microscopies, and bringing these new technologies to bear against basic biological questions of genomic and epigenomic variation.
2014-15 Courses
- Advanced Imaging Lab in Biophysics
APPPHYS 232, BIO 132, BIO 232, BIOPHYS 232, GENE 232 (Spr)
- Genetics and Developmental Biology Training Camp
DBIO 200, GENE 200 (Aut)
- Next Generation Sequencing and Applications
BIOS 201 (Spr)
Independent Studies (11)
- Biomedical Informatics Teaching Methods
BIOMEDIN 290 (Aut, Win, Spr)
- Directed Investigation
BIOE 392 (Aut)
- Directed Reading and Research
BIOMEDIN 299 (Aut, Win, Spr, Sum)
- Directed Reading in Biophysics
BIOPHYS 399 (Aut, Win, Spr)
- Directed Reading in Genetics
GENE 299 (Aut, Win, Spr, Sum)
- Graduate Research
BIOPHYS 300 (Aut, Win, Spr)
- Graduate Research
GENE 399 (Aut, Win, Spr, Sum)
- Medical Scholars Research
BIOMEDIN 370 (Aut, Win, Spr, Sum)
- Medical Scholars Research
GENE 370 (Aut, Win, Spr, Sum)
- Supervised Study
GENE 260 (Aut, Win, Spr, Sum)
- Undergraduate Research
GENE 199 (Aut, Win, Spr, Sum)
- Biomedical Informatics Teaching Methods
Prior Year Courses
2013-14 Courses
- Advanced Imaging Lab in Biophysics
APPPHYS 232, BIO 132, BIO 232, BIOPHYS 232, MCP 232 (Spr)
- Genetics and Developmental Biology Training Camp
GENE 200 (Aut)
- Next Generation Sequencing and Applications
BIOS 201 (Win)
2012-13 Courses
- Genetics and Developmental Biology Training Camp
GENE 200 (Aut)
- Next Generation Sequencing and Applications
BIOS 201 (Win)
- Advanced Imaging Lab in Biophysics
Postdoctoral Advisees
Graduate and Fellowship Programs
Biomedical Informatics (Phd Program)
All Publications
A pause sequence enriched at translation start sites drives transcription dynamics in vivo
2014; 344 (6187): 1042-1047
Transcription by RNA polymerase (RNAP) is interrupted by pauses that play diverse regulatory roles. Although individual pauses have been studied in vitro, the determinants of pauses in vivo and their distribution throughout the bacterial genome remain unknown. Using nascent transcript sequencing, we identified a 16-nucleotide consensus pause sequence in Escherichia coli that accounts for known regulatory pause sites as well as ~20,000 new in vivo pause sites. In vitro single-molecule and ensemble analyses demonstrate that these pauses result from RNAP-nucleic acid interactions that inhibit next-nucleotide addition. The consensus sequence also leads to pausing by RNAPs from diverse lineages and is enriched at translation start sites in both E. coli and Bacillus subtilis. Our results thus reveal a conserved mechanism unifying known and newly identified pause events.
View details for DOI 10.1126/science.1251871
View details for Web of Science ID 000336495800049
View details for PubMedID 24789973
Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position
2013; 10 (12): 1213-?
We describe an assay for transposase-accessible chromatin using sequencing (ATAC-seq), based on direct in vitro transposition of sequencing adaptors into native chromatin, as a rapid and sensitive method for integrative epigenomic analysis. ATAC-seq captures open chromatin sites using a simple two-step protocol with 500-50,000 cells and reveals the interplay between genomic locations of open chromatin, DNA-binding proteins, individual nucleosomes and chromatin compaction at nucleotide resolution. We discovered classes of DNA-binding factors that strictly avoided, could tolerate or tended to overlap with nucleosomes. Using ATAC-seq maps of human CD4(+) T cells from a proband obtained on consecutive days, we demonstrated the feasibility of analyzing an individual's epigenome on a timescale compatible with clinical decision-making.
View details for DOI 10.1038/NMETH.2688
View details for Web of Science ID 000327698100025
View details for PubMedID 24097267
Pulling out the 1%: Whole-Genome Capture for the Targeted Enrichment of Ancient DNA Sequencing Libraries
2013; 93 (5): 852-864
View details for DOI 10.1016/j.ajhg.2013.10.002
View details for Web of Science ID 000326996600006
Digital Polymerase Chain Reaction in an Array of Femtoliter Polydimethylsiloxane Microreactors
2012; 84 (10): 4262-4266
We developed a simple, compact microfluidic device to perform high dynamic-range digital polymerase chain reaction (dPCR) in an array of isolated 36-femtoliter microreactors. The density of the microreactors exceeded 20000/mm(2). This device, made from polydimethylsiloxane (PDMS), allows the samples to be loaded into all microreactors simultaneously. The microreactors are completely sealed through the deformation of a PDMS membrane. The small volume of the microreactors ensures a compact device with high reaction efficiency and low reagent and sample consumption. Future potential applications of this platform include multicolor dPCR and massively parallel dPCR for next generation sequencing library preparation.
View details for DOI 10.1021/ac300761n
View details for Web of Science ID 000303965500005
View details for PubMedID 22482776
Fluorogenic DNA sequencing in PDMS microreactors
We developed a multiplex sequencing-by-synthesis method combining terminal phosphate-labeled fluorogenic nucleotides (TPLFNs) and resealable polydimethylsiloxane (PDMS) microreactors. In the presence of phosphatase, primer extension by DNA polymerase using nonfluorescent TPLFNs generates fluorophores, which are confined in the microreactors and detected. We immobilized primed DNA templates in the microreactors, then sequentially introduced one of the four identically labeled TPLFNs, sealed the microreactors and recorded a fluorescence image after template-directed primer extension. With cycle times of <10 min, we demonstrate 30 base reads with ?99% raw accuracy. Our 'fluorogenic pyrosequencing' offers benefits of pyrosequencing, such as rapid turnaround, one-color detection and generation of native DNA, along with high detection sensitivity and simplicity of parallelization because simultaneous real-time monitoring of all microreactors is not required.
View details for DOI 10.1038/NMETH.1629
View details for Web of Science ID 000292194500021
View details for PubMedID 21666670
2010; 475: 377-404
We present details of the design, construction, and testing of a single-beam optical tweezers apparatus capable of measuring and exerting torque, as well as force, on microfabricated, optically anisotropic particles (an "optical torque wrench"). The control of angular orientation is achieved by rotating the linear polarization of a trapping laser with an electro-optic modulator (EOM), which affords improved performance over previous designs. The torque imparted to the trapped particle is assessed by measuring the difference between left- and right-circular components of the transmitted light, and constant torque is maintained by feeding this difference signal back into a custom-designed electronic servo loop. The limited angular range of the EOM (+/-180 degrees ) is extended by rapidly reversing the polarization once a threshold angle is reached, enabling the torque clamp to function over unlimited, continuous rotations at high bandwidth. In addition, we developed particles suitable for rotation in this apparatus using microfabrication techniques. Altogether, the system allows for the simultaneous application of forces (approximately 0.1-100 pN) and torques (approximately 1-10,000 pN nm) in the study of biomolecules. As a proof of principle, we demonstrate how our instrument can be used to study the supercoiling of single DNA molecules.
View details for DOI 10.1016/S0076-6879(10)75015-1
View details for Web of Science ID 000280733800015
View details for PubMedID 20627165
Applied force reveals mechanistic and energetic details of transcription termination
2008; 132 (6): 971-982
Transcription termination by bacterial RNA polymerase (RNAP) occurs at sequences coding for a GC-rich RNA hairpin followed by a U-rich tract. We used single-molecule techniques to investigate the mechanism by which three representative terminators (his, t500, and tR2) destabilize the elongation complex (EC). For his and tR2 terminators, loads exerted to bias translocation did not affect termination efficiency (TE). However, the force-dependent kinetics of release and the force-dependent TE of a mutant imply a forward translocation mechanism for the t500 terminator. Tension on isolated U-tracts induced transcript release in a manner consistent with RNA:DNA hybrid shearing. We deduce that different mechanisms, involving hypertranslocation or shearing, operate at terminators with different U-tracts. Tension applied to RNA at terminators suggests that closure of the final 2-3 hairpin bases destabilizes the hybrid and that competing RNA structures modulate TE. We propose a quantitative, energetic model that predicts the behavior for these terminators and mutant variants.
View details for DOI 10.1016/j.cell.2008.01.027
View details for Web of Science ID 000254273600016
View details for PubMedID 18358810
Direct observation of hierarchical folding in single riboswitch aptamers
2008; 319 (5863): 630-633
Riboswitches regulate genes through structural changes in ligand-binding RNA aptamers. With the use of an optical-trapping assay based on in situ transcription by a molecule of RNA polymerase, single nascent RNAs containing pbuE adenine riboswitch aptamers were unfolded and refolded. Multiple folding states were characterized by means of both force-extension curves and folding trajectories under constant force by measuring the molecular contour length, kinetics, and energetics with and without adenine. Distinct folding steps correlated with the formation of key secondary or tertiary structures and with ligand binding. Adenine-induced stabilization of the weakest helix in the aptamer, the mechanical switch underlying regulatory action, was observed directly. These results provide an integrated view of hierarchical folding in an aptamer, demonstrating how complex folding can be resolved into constituent parts, and supply further insights into tertiary structure formation.
View details for DOI 10.1126/science.1151298
View details for Web of Science ID 000252772000044
View details for PubMedID 18174398
Single-molecule studies of RNA polymerase: Motoring along
2008; 77: 149-176
Single-molecule techniques have advanced our understanding of transcription by RNA polymerase (RNAP). A new arsenal of approaches, including single-molecule fluorescence, atomic-force microscopy, magnetic tweezers, and optical traps (OTs) have been employed to probe the many facets of the transcription cycle. These approaches supply fresh insights into the means by which RNAP identifies a promoter, initiates transcription, translocates and pauses along the DNA template, proofreads errors, and ultimately terminates transcription. Results from single-molecule experiments complement the knowledge gained from biochemical and genetic assays by facilitating the observation of states that are otherwise obscured by ensemble averaging, such as those resulting from heterogeneity in molecular structure, elongation rate, or pause propensity. Most studies to date have been performed with bacterial RNAP, but work is also being carried out with eukaryotic polymerase (Pol II) and single-subunit polymerases from bacteriophages. We discuss recent progress achieved by single-molecule studies, highlighting some of the unresolved questions and ongoing debates.
View details for DOI 10.1146/annurev.biochem.77.073106.100741
View details for Web of Science ID 000257596800008
View details for PubMedID 18410247
Molecule by molecule, the physics and chemistry of life: SMB 2007.
2007: 193-197
Interdisciplinary work in the life sciences at the boundaries of biology, chemistry and physics is making enormous strides. This progress was showcased at the recent Single Molecule Biophysics conference.
View details for PubMedID 17372599
High-resolution, single-molecule measurements of biomolecular motion
2007; 36: 171-190
Many biologically important macromolecules undergo motions that are essential to their function. Biophysical techniques can now resolve the motions of single molecules down to the nanometer scale or even below, providing new insights into the mechanisms that drive molecular movements. This review outlines the principal approaches that have been used for high-resolution measurements of single-molecule motion, including centroid tracking, fluorescence resonance energy transfer, magnetic tweezers, atomic force microscopy, and optical traps. For each technique, the principles of operation are outlined, the capabilities and typical applications are examined, and various practical issues for implementation are considered. Extensions to these methods are also discussed, with an eye toward future application to outstanding biological problems.
View details for DOI 10.1146/annurev.biophys.36.101106.101451
View details for Web of Science ID 000247773000009
View details for PubMedID 17328679
High-resolution, single-molecule optical trapping measurements of transcription with basepair accuracy: Instrumentation and methods
2007; 6644
View details for DOI 10.1117/12.739631
View details for Web of Science ID 000251162100004
Single-molecule, motion-based DNA sequencing using RNA polymerase
2006; 313 (5788): 801-801
We present a method for sequencing DNA that relies on the motion of single RNA polymerase molecules. When a given nucleotide species limits the rate of transcription, polymerase molecules pause at positions corresponding to the rare base. An ultrastable optical trapping apparatus capable of base pair resolution was used to monitor transcription under limiting amounts of each of the four nucleotide species. From the aligned patterns of pauses recorded from as few as four molecules, we determined the DNA sequence. This proof of principle demonstrates that the motion of a processive nucleic acid enzyme may be used to extract sequence information directly from DNA.
View details for DOI 10.1126/science.1130105
View details for Web of Science ID 000239671300049
View details for PubMedID 16902131
Direct observation of base-pair stepping by RNA polymerase
2005; 438 (7067): 460-465
During transcription, RNA polymerase (RNAP) moves processively along a DNA template, creating a complementary RNA. Here we present the development of an ultra-stable optical trapping system with ångström-level resolution, which we used to monitor transcriptional elongation by single molecules of Escherichia coli RNAP. Records showed discrete steps averaging 3.7 +/- 0.6 A, a distance equivalent to the mean rise per base found in B-DNA. By combining our results with quantitative gel analysis, we conclude that RNAP advances along DNA by a single base pair per nucleotide addition to the nascent RNA. We also determined the force-velocity relationship for transcription at both saturating and sub-saturating nucleotide concentrations; fits to these data returned a characteristic distance parameter equivalent to one base pair. Global fits were inconsistent with a model for movement incorporating a power stroke tightly coupled to pyrophosphate release, but consistent with a brownian ratchet model incorporating a secondary NTP binding site.
View details for DOI 10.1038/nature04268
View details for Web of Science ID 000233458200041
View details for PubMedID 16284617
Passive all-optical force clamp for high-resolution laser trapping
2005; 95 (20)
Optical traps are useful for studying the effects of forces on single molecules. Feedback-based force clamps are often used to maintain a constant load, but the response time of the feedback limits bandwidth and can introduce instability. We developed a novel force clamp that operates without feedback, taking advantage of the anharmonic region of the trapping potential where the differential stiffness vanishes. We demonstrate the utility of such a force clamp by measuring the unfolding of DNA hairpins and the effect of trap stiffness on opening distance and transition rates.
View details for DOI 10.1103/PhysRevLett.95.208102
View details for Web of Science ID 000233243500069
View details for PubMedID 16384102


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Thousands Of Students March In Support Of Education And The Welfare State
Protesters scuffle with police and shout slogans during a... Fotografia de notíciasAprender,Assunto,Bestof,Bestpix,Brigar,Casas do Parlamento,Educação,Força policial,Gritar,Horizontal,Inglaterra,Londres - Inglaterra,Placa de manifestação,Ponto Turístico Internacional,Protestante,Protesto,Reino Unido,TopixPhotographer Warrick PageCollection: Getty Images News 2012 Getty ImagesLONDON, UNITED KINGDOM - NOVEMBER 21: Protesters scuffle with police and shout slogans during a demonstration against education cuts, tuition increases and austerity outside the Houses of Parliament on November 21, 2012 in London, England. The demonstration march was organised by the National Union of Students and is the first national student protest since a series of violent protests against tuition fees two years ago. (Photo by Warrick Page/Getty Images)


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marijuana - Page 3
Wyo. Highway Patrol K-9 Scores a Hit
Nation's First Marijuana Club Closes After One Day
Wyoming Braced for Impacts of CO Pot Law
Pot Regulation Work begins in Colorado
Traffic Stop Turns Up 60 lbs of Marijuana
Wyo. Ed Chief Hill To Guest on The Morning Zone Today
Today at 9:07AM MDT, Wyoming State Superintendent of Education, Cindy Hill will be back with us on The Morning Zone. We will talk with Cindy about the proposed new K-12 standards for math, language arts, health, foreign language and more, plus, more on the newly legislated state law that requires school districts to implement the 16:1 student teacher ratio, and about how the Department will consider district requests for temporary waivers to that law in the next few years while they plan and build new schools to bring them into compliance...
On The Morning Zone, Mexican cops storm drug cartel ranch killing 11
- Jim Kouri will be our guest at 7:07AM MDT this morning on The Morning Zone
- By Jim Kouri
- Mexican police officers reported Saturday that they've killed at least 11 La Familia drug cartel members after an intense shoot-out at the crime gang's western Mexico ranch, a U
Rep. Issa Threatens Obama's ATF with Contempt
By Jim Kouri
"If you do not comply with the subpoena, the Committee will be forced to commence contempt proceedings."
Rep. Darrell Issa (R-CA), the Chairman of the House Committee on Oversight and Government Reform, in a biting letter to Bureau of Alcohol, Tobacco, Firearms, and Explosives (ATF) Acting Director Kenneth E. Melson, criticized the Director for failing to produce any documents in response to a subpoena issued more almost a month ago on March 31.
Legislature: No Recognition of Marijuana Prescriptions from Other States
Students from the Cody organization "Youth for Justice" lobby lawmakers to make "spice" a schedule one drug. A bill, sponsored by House Speaker Ed Buchanan, proposes Wyoming will not recognize marijuana prescriptions from other states. Click past the jump to listen to the Legislative Report.


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This year our daughter asked if she could draw the family portrait for our holiday card. She worked very hard and we're proud as heck to share the result.
Hello all. Most of my blogging energy has been absorbed by another project for quite some time now. Otherwise things are pretty much the same here. I've really been enjoying the liberation that comes from never worrying about what the next blog post needs to be about and just making dozens of things that I haven't shared here. But if there are folks out there still interested, I may pop in from time to time to share a few of the things we've been up to.
If there was one thing that got us through that winter, it was chapter books. We rearranged the shelves and boxed up hundreds of picture books and just started binging on more serious reads at bedtime and through those long cooped-up winter days. To all the parents of younger kids out there dedicated to reading those picture books to babies and toddlers every night, let me speak to you from your not-too-distant future: it gets so awesome when you finally put down the picture books and start sharing more demanding stories. That's especially true when you start tearing through your own favorite books from childhood, watching them in their beds painting their own pictures with those words coming from your lips. My wife has read them dozens of novels---new and old---at bedtime over the past few months. And I always end the night with poems to remind them that words can be beautiful even if they don't always make sense, so we've been on a steady diet of Hopkins and Frost and Yeats.
My daughter's favorite book is Roald Dahl's The BFG, which I never read as a kid but she has now finished eight or nine times. It's about this massive-eared "Big Friendly Giant" who comes to kids windows at night and blows dreams into their ears with a long trumpet-like horn. For a girl who has always had some anxiety about sleep, there seems to be comfort in the story of a goofball giant who brings sweet dreams and banishes nightmares and who farts (whizpops) a lot after drinking his favorite drink (frobscottle) and speaks in a hilariously confused English. For her birthday I decided to make her a BFG doll for her bed just to make sure she always has good dreams. I did some research about how dolls are made and taught myself to use my wife's sewing machine, and it took a great deal of courage to overcome my fear of losing whatever shred of masculinity I had left. I think it all drifted away like silvery waves of gossamer while I crouched over that machine sewing pants for a naked bald-headed man doll.


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John Hodgman appears in the following:
The Greene Space
Bullseye Presents: 'Make Your Thing' with Jesse Thorn and John Hodgman
Friday, November 20, 2015
Fri, Nov 20 | Is it possible to merge the commercial world with nonprofit ideals? Jesse Thorn shows us how in this hour-long talk. Followed by a Q&A led by John Hodgman.
John Hodgman Judges Your Jokes
Tuesday, May 20, 2014
You think you have a funny joke. Author, actor and humorist John Hodgman will judge it on its merits. Plus: he'll talk about the Ragnarok Survival Kit he has put together.
Guest Picks: John Hodgman
Thursday, June 20, 2013
John Hodgman was on the Leonard Lopate Show recently to to talk about his comedy special "Ragnarok" and how to prepare for the end of the world. Find out who he wants to live with on a boat.
John Hodgman: Ragnarok
Thursday, June 20, 2013
John Hodgman shares his survival guide to the Mayan apocalypse, or as he calls it "Ragnarok." His post-apocalyptic necessities include beef jerky dollars, sperm whales, and mayonnaise, His new comedy special "John Hodgman: Ragnarok," is streaming exclusively on Netflix.
John Hodgman on the End of the World
Wednesday, June 19, 2013
Humorist, writer, and Daily Show "resident expert" John Hodgman has been thinking about the end of the world, and joking about it for the past year on stages across America. His new special documents the last night of his doomsaying tour. It's called "Ragnarok" (as in the Norse mythology version of the end of the world). "Ragnarok" will be available exclusively on Netflix tomorrow, June 20.
The Daily Show's John Hodgman and Wyatt Cenac
Wednesday, June 20, 2012
The Daily Show's resident expert John Hodgman and Wyatt Cenac, Emmy Award-winning writer and correspondent on The Daily Show, talk about political humor, the election, and about what goes on behind the scenes of the show. And they'll talk about Comedy Central's "Indecision in the Park," which features stand-up performances by Daily Show correspondents, including Wyatt Cenac, Al Madrigal, John Oliver, contributor Kristen Schaal, and others, and is hosted by John Hodgman. "Indecision in the Park" takes place June 20, at 8:00 pm, at SummerStage in Central Park.
Guest Picks: John Hodgman
Monday, December 12, 2011
Writer (and sometime guest host of the Lopate Show) John Hodgman spoke to Leonard about That Is All, the last part of his trilogy called Complete World Knowledge. He also revealed what his comfort food is and why he loved Cormac McCarthy's novel The Road.
John Hodgman's That Is All
Monday, December 12, 2011
John Hodgman discusses the third and final installment in his trilogy of Complete World Knowledge, That Is All. Like its predecessors, this book compiles incredibly handy made-up facts into brief articles, overlong lists, and fascinating narratives on new and familiar themes.
The Greene Space
The Sound of Young America Live
Friday, October 22, 2010
The Sound of Young America returns to New York City for its second stint at The Greene Space at WNYC. Hosted by Jesse Thorn, The Sound of Young America will present its signature blend of comedy, cabaret, and music in front of a live audience.
Guest Picks: John Hodgman
Friday, September 10, 2010
John Hodgman talks about his favorite books, movies, and more after his recent appearance on The Leonard Lopate Show
John Hodgman's Areas of Expertise
Friday, September 10, 2010
Humorist John Hodgman, author of The Areas of My Expertise and More Information Than You Require, discusses his particular kind of humor and his work on The Daily Show. He'll also talk about taking part in the Brooklyn Book Festival's panel on humor writing.
John Hodgman and the Media Geeks
Monday, June 22, 2009
Geeks deserve more credit than they probably get. That's the that argument John Hodgman — writer, actor, comedian, and self-professed nerd — took to the President this weekend, the supposed Nerd in Chief, when he was the keynote speaker at the annual Radio and TV Correspondents' dinner in Washington. John Hodgman joins The Takeaway, fresh from his stint. (He spoke after the President, he'll have you know.)
Watch John Hodgman address the Correspondents' Dinner:


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It was possibly the most high profile piece of legislation at the capital this session. House Bill 11 was a plan to pull $2 Billion from the states rainy day fund, to fund water projects in Texas for the next 50 years. It had the backing of the governor, the state's business community, and many environmental groups. But last night it could not muster the votes to gain approval in the Texas House of Representatives.
By: </a>Mose Buchele, KUT, April 30th, 2013 04:28 PM
4343 Elgin Street, Houston, TX 77204
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The helpful staff at Martinsville Speedway is available Monday through Friday to answer any questions you may have about your visit to Martinsville or the Speedway. For answers to all ticket questions, please call us toll free at 877-RACE-TIX (877-722-3849).
You may also email us at firstname.lastname@example.com
Upcoming Events
Oct11ValleyStar Credit Union 300For a fast and furious day of racing, don't miss the the ValleyStar Credit Union 300, the biggest NASCAR Late Model Stock car race in the nation. Detailed information coming soon. Tickets are on sale NOW! Adults $30, Youth 12 and under $5
Oct30Virginia Lottery Pole DayCome watch the NASCAR Sprint Cup and Truck series drivers get their cars and trucks dialed in with practice and cup qualifying. Youth 12 and under FREE!
Oct31Kroger 200The NASCAR Camping World Truck Series returns to short-track racing at Martinsville Speedway.
Nov1Goody's Headache Relief Shot 500Can Dale Jr. repeat? That's the big question headed into the Goody's® Headache Relief Shot® 500, the seventh stop in the Chase for the Sprint Cup.
Phone Hours
Monday - Friday: 9 a.m. to 9 p.m.
Saturday - Sunday: 9 a.m. to 7 p.m.
Martinsville Local Ticket Office Hours
Monday - Friday 9 a.m. to 5 p.m.
Ticket Office
Phone: 877-RACE-TIX (877-722-3849)
Fax: 276-956-2820
Lost Or Stolen Tickets
We are not responsible for lost or stolen tickets. Please call the ticket office for the lost/stolen ticket policy. Call toll free 877-RACE-TIX.
In case of postponement, race ticket will be good for race at time and date announced.


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Small business owners can learn how to lower their tax bills, choose tax preparers and gauge potential vulnerabilities by taking advantage of free webinars hosted by government agencies. The IRS, National Federation of Independent businesses and U.S. Small Business Administration sponsor webinars that small business owners can watch from their home or office.
The IRS recently hosted a "Small Business Tax Compliance" webinar to teach small business owners and those who are self-employed useful approaches to compliance and working with tax professionals.
Small business owners can gain important tax knowledge through webinars hosted by the NFIB such as "Tax Planning 2012: Get a Head Start on the New Year by Getting Your 2011 Taxes Right" in which they discuss how organizations can get the lowest possible tax bill.
The SBA is offering monthly seminars on "Small Business Disaster Preparedness" so business owners can identify potential vulnerabilities, learn to analyze risks and plan a recovery. Small businesses can learn from the experts and potentially participate in the discussion by investing in web conferencing solutions.


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10 Delightful Derailleurs
EGS Up-Cage
4 / 10
"There are people who say this is the best derailleur ever made," says Sweatman, "and EGS probably only sold 25 of them." Despite an amazing design, this was a commercial disaster.
Brand: EGS
Country: France
Date of Introduction: 1998*
Weight: 246g
Specs for Fanatics:
Maximum cog: 34 teeth*
Total Capacity: 43 teeth*
Pulley center to center: 43mm
Index capability: 9 speed*
Chain width: 3/32"
Logic: top normal
Material: aluminum with titanium bolts and brass (phosphor bronze?) parallelogram pivots and cable and chain wear points Pivots: two pivots, front sprung and rear unsprung
Copyright © 2015 Rodale Inc.


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October 2012 WinnerSEVA GRREAT TestimonialTHANK YOU again so much for allowing us to be part of your program. We are so grateful for the $5,000 quarterly award that we won and we have been very busy putting it to very good use! Since receiving the award, we have had 25 intakes, so needless to say, it has been a busy fall/winter season for us. With your generous award, we were able to pay for the microchipping of each of these dogs as they have come into the program. As you know, we do microchip all of our dogs if they come in without one, so your support in this area is definitely appreciated!
This season has been especially challenging for us because some of the dogs that we have accepted into our program are "special needs" dogs. We don't turn away dogs that need significant medical care because often, these are the times when they need us the most.
Just to give you an update on some of our dogs:
Peaches came to us from the Dinwiddie Animal shelter as a golden that is most likely mixed with a yellow lab. This poor little girl had been a stray and had run through some barbed wire where she cut her nose. Peaches is very emaciated and has a skin infection at this time. Once her infection is cleared up and we put some weight on her, we will have her spayed and get her ready for her fur-ever home.
Emma is a very sweet older golden that came into the SEVA GRREAT program from a local shelter where she appeared to be very depressed. Upon medical examination, we learned that she was at least 11 years old, deaf, heartworm positive, erlichia positive, and also tested positive for lyme disease. Thanks to your generous support and the outstanding network of foster homes we have, Emma lived out the rest of her life with SEVA GRREAT, knowing that she was loved. Emma crossed the Rainbow Bridge at the end of November in the loving arms of her foster family. It was heartbreaking to see her go, but it comforts us to know that she was able to experience a warm, happy home and the love of a foster family that adored her.
Tessa also came to us from a local shelter where they believe she may have been hit by a car at some point in her life. Her pelvis appeared to be shattered and although it healed, she has a limited range of movement. Well, she is definitely ending the year the right way…not only has she found her fur-ever home but we are happy to report that she has not had to have her leg amputated. We are wishing her and her new family a very bright and happy new year!
Chipper was one of the older fellas in our program who came in as a stray, but even at 10 years old he was a man who evidently liked excitement and variety in his life. On November 17th, we had received a call that Chipper had escaped from his first foster home. Since we knew he could jump fences, we were all very concerned but luckily he was found a few hours later. Once he was found, we heard the story of his adventure and couldn't believe it. Evidently, Chipper is a talented old boy who not only jumps over fences, but also knows how to open the gate latch. That day he decided to let himself out of his yard and then proceeded to walk down the street and spring two of his canine friends out of their yards with his gate latch trick! This sounded like something from a movie and everyone thought it was cute until he escaped from his yard four days later. Thank goodness we have a good group of fosters and in this case, we had a new foster family for Chipper with a tall fence and a gate that locked. I guess Chipper must have known that he was close to getting his fur-ever home and was in a hurry to get there since he was adopted out to a wonderful family just a few days later!
We are still supporting some of our other "special needs" dogs like Woody and Blondie and we hope that the new year will bring them their fur-ever homes with wonderful families just like Tessa and Chipper.
Again, we cannot thank you enough for your generous support of these wonderful animals. We cannot do what we do without help and this award was huge for us!
Mary Strzelecki, Fundraising Coordinator
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Jimmy Wales: Google is secret, proprietary, closed. Search should be open.
In Friday's WallStrip, there's an intersting interview with Wikipedia's Jimmy Wales. For me, the key bit comes about 80% of the way in (4:11), where Jimmy comments on Google. Emphasis mine:
Lindsay Campbell: What's wrong with Google, and how will Wikia's search be different?
Jimmy Wales: I think the main thing that is wrong with Google is that everything is secret, proprietary, closed… I'm a big believer in openness and transparency, ah, open source software, open protocols, and I think search should be open as well.
Campbell: How would that work? Functionally…?
Wales: Well, we haven't invented it yet.
I've been thinking about Google's opacity a good deal recently, and have a medium-sized post on this topic coming out Tuesday on Search Engine Land.
In Tuesday's post, I suggest Google is remarkably opaque towards their advertisers. Google obfuscates click cost info (providing costs only in aggregate, rather than click-level reporting), obfuscates ad ranking (quality score), and obfuscates ad matching (broad match), etc. I also suggest that if Google embraced extreme transparency — if they could overcome the substantial associated business risk — Google would enjoy (even more) explosive growth and (even more) market dominance. While I'm bearish on Wikia, I think Wales is totally right on the money with his comments on Google's secrecy.
Prediction: Google's lack of transparency becomes a significant issue in late '07 / early '08.


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Michael Horn
President and CEO of Volkswagen Group of America
Michael Horn is the president and CEO of Volkswagen Group of America (VWGOA) as well as president for the Volkswagen of America brand. Horn assumed this position in January 2014.
Horn joined VWGOA with twenty three years of experience with Volkswagen. Most recently, Horn served as the Global Head of After Sales at Volkswagen AG (VW). Horn joined Volkswagen in 1990 and has held many roles within the Volkswagen Brand, including Head of Volkswagen sales North West Europe, Head of sales and marketing luxury class vehicles, and Head of sales for Europe since 2004.
Horn, a native from Hamburg, Germany is 51 years old. He earned a bachelor's degree in Business Administration from the European University in Antwerp, Belgium and a Master of Business Administration from the University of San Francisco.
Scott Keogh
President, Audi of America, Inc.
HERNDON, Va., June 20, 2012 – Audi will build on its record-setting performance in the U.S. market with a new President to lead Audi of America.
Scott Keogh will assume the top leadership role for Audi brand activities across the U.S. effective immediately. Keogh comes into the job with experience of six years as Chief Marketing Officer at Audi of America. In that position, he led all product planning for the U.S. market in addition to award-winning marketing and advertising campaigns that helped Audi of America achieve record levels of consumer awareness and consideration.
A strong advocate for Audi performance and efficiency engineering, Keogh helped steer the introduction of Audi TDI clean diesel technology to the U.S. market by positioning it as a social cause rather than a mere engine variant. He developed the strategy to re-introduce RS performance models, including the new RS 5 coupe coming to dealerships this year, to the American premium sports car segment. Keogh also advocated for the return this year of the iconic Audi allroad, as part of a strategy that has resulted in 14 new Audi model launches for American consumers since 2006.
Among the Audi brand accomplishments led by Keogh – each with its own portion of risk and unconventional thinking for the segment – have been early awareness-building exercises such as the Truth in 24 documentaries about the Audi dominance at the 24 Hours of Le Mans endurance race; bold Super Bowl advertising; a significant push into social media; and integration of Audi into blockbuster Hollywood productions, such as the Iron Man movie series.
The Audi brand has established sales records over the past 17 consecutive months, culminating in an all-time annual record of 117,561 premium performance models sold nationwide in 2011. That topped the previous annual sales record of 101,629 Audi vehicles sold in the U.S. market just one year earlier.
"We see exceptional growth opportunity in the U.S. market as we continue moving toward our goal of positioning Audi as the leading luxury automotive brand in the world by 2020," said Rupert Stadler, AUDI AG Chairman and Chief Executive Officer. "Gains in the U.S. are truly a strategic pillar for the brand and we are confident that the leadership provided by Scott Keogh will continue the momentum at Audi of America."
Audi of America has shown momentum across its businesses. Consumer awareness and consideration are at an all-time high level thanks to Audi of America marketing and media activities. Audi Parts and Accessories sales reached record levels in 2011, and are poised to eclipse those results in 2012. Audi Certified pre-owned sales achieved record numbers in 2011, as well. The 278 Audi dealer partners in the U.S. are seeing record returns on sales on average, and the brand demonstrated solid profitability in the U.S. last year.
"Audi has demonstrated remarkable progress in recent years," Keogh said today at Audi of America headquarters in Herndon. "There is much work to be done in a highly competitive segment of the auto business. But the sights are set and the team is in place to meet our goals."
As the next Audi of America President, Keogh replaces Johan de Nysschen who led the organization over the past 7 ½ years in an Audi career that spanned nearly 20 years.
Dr. Christian Dahlheim
President and Chief Executive Officer, VW Credit, Inc.
Christian Dahlheim is President and Chief Executive Officer for VW Credit, Inc. In this role Dahlheim oversees all functions of VW Credit, Inc., the captive finance company which services Volkswagen, Audi and Ducati customers, authorized automotive dealers and their affiliated stores as Volkswagen Credit and Audi Financial Services.
Dahlheim came to the position with over 18 years of finance and leadership experience most recently serving as Executive Vice President & Chief Financial Officer for VW Credit, Inc. Dr. Dahlheim joined Volkswagen Financial Services AG in 2005. Previously, Dr. Dahlheim was the Regional Manager, Europe & International, for Volkswagen Financial Services AG, responsible for the Financial Services businesses of the VW Group in Europe and selected overseas markets. Dr. Dahlheim has held various positions of increased responsibilities in the fields of engineering, consulting, financial services and automotive.
Dr. Dahlheim holds a Ph.D. from the European Business School in Economics, an MBA from the Anderson School at UCLA, and a Master's Degree from Technische Universität München in Physics.


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Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases (TRANSREG)
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
TRANSREG will assess the safety and biological efficacy of low-dose IL2 as a Treg inducer in a set of 11 autoimmune and auto-inflammatory diseases, with the aim to select diseases in which further therapeutic development will be performed. Extensive biological- and immune-monitoring pre- and post-IL2 will contribute (i) to define the common or distinct processes responsible for the breakdown of immunological tolerance in these pathologies and (ii) to discover potential biomarkers of the IL2 response.
Rheumatoid Arthritis
Ankylosing Spondylitis
Systemic Lupus Erythematosus
Behcet's Disease
Wegener's Granulomatosis
Takayasu's Disease
Crohn's Disease
Ulcerative Colitis
Autoimmune Hepatitis
Sclerosing Cholangitis
Drug: Interleukin 2
Phase 2
|Study Type:
|Study Design:
|Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|Induction of Regulatory t Cells by Low Dose IL2 in Autoimmune and Inflammatory Diseases: a Transnosographic Approach
- Percentages of Tregs [ Time Frame: Day8 ] [ Designated as safety issue: No ]Change in Treg percentage (percentages of Tregs within the CD4+ lymphocytes) at Day-8 after administration of low-dose of IL2 compared to baseline (Day0)
- Percentages of Tregs [ Time Frame: Day 15, 29, 85, 183 and 240 ] [ Designated as safety issue: No ]Changes in Treg percentage at Day 15, 29, 85, 183 and 240 compared to baseline (Day0)
- CRP, CRP ulta sensible, PCT, Albumin, LDH, anemia [ Time Frame: Day 0, 1, 8, 15, 29, 85, 183 and 240 ] [ Designated as safety issue: Yes ]Changes in levels of inflammation markers
- Number of relapses [ Time Frame: up to Day240 ] [ Designated as safety issue: Yes ]
- CGI-sev and CGI-eff scales [ Time Frame: Day 85, 183 and 240 ] [ Designated as safety issue: No ]Change in the clinical global impression severity and efficacy scale (CGI-sev and scale, CGI-eff scales) at Day 85, 183 and 240 compared to baseline (Day1)
- EuroQL-5 scale [ Time Frame: Day 183 ] [ Designated as safety issue: No ]Change in the quality of life (EuroQL-5 scale)
- Evolution of clinical, biological or radiological criteria specific to each disease [ Time Frame: up to Day 240 ] [ Designated as safety issue: No ]Changes in disease-specific score and/or evolution of clinical, biological or radiological criteria specific to each disease
- Safety Assessment [ Time Frame: up to Day 240 ] [ Designated as safety issue: Yes ]Safety Assessment all along the observation period (Day-1 to Day-240): Safety assessment will include vital signs, adverse events and concomitant medications collection as well as biology during the 6 months of the treatment period; .In addition, the evolution of the disease will be followed 2,5 months after IL2- treatment stop.
|Estimated Enrollment:
|Study Start Date:
|January 2014
|Estimated Study Completion Date:
|October 2016
|Estimated Primary Completion Date:
|January 2016 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Interleukin 2
Interleukin 2, 1MUI.= Proleukin®
Drug: Interleukin 2
Induction period: repeated administration of low-dose IL-2 (1MUI/day, sc) during 5 consecutive days.Maintenance period: treatment with IL-2, 1MUI once every 15 days for 6 months
Detailed Description:
Protocol: TRANSREG is a multicentric, uncontrolled, open-label study, comparing biological and clinical responses to the administration of low doses IL2 across 11 selected pathologies: rheumatoid arthritis, ankylosing spondylitis, systemic lupus erythematosus, psoriasis, Behcet's disease, Wegener's granulomatosis, Takayasu's disease, Crohn's disease, ulcerative colitis, autoimmune hepatitis, and sclerosing cholangitis.Methods: Each patient will receive 1MUI /day of IL2 from Day-1 to Day-5 (the induction period), and then every 2 weeks from Day-15 to Day-180 (the maintenance period). Patients will thereafter be followed up for 2 months (Day-181-Day-240). For each pathology, 6 patients will be included at Pitié-Salpêtrière, Cochin and Saint Antoine hospitals in Paris. An interim analysis will be performed in each pathology group when the first six patients have received at least 3 months of treatment. In those pathology groups in which a Treg response will be documented, six additional patients will be included. In total, a minimum of 66 patients and up to 132 patients will be enrolled in this study. Primary efficacy endpoint is the Treg response at Day-8. Secondary endpoints are:- the Treg response during the maintenance period,- the changes in markers of inflammation - the clinical response, evaluated by means of global generic scales [Clinical Global Impression severity scale (CGI-sev) and Clinical Global Impression efficacy index (CGI-eff)] as well as specific clinical and biological evaluations for each disease, - the frequency of relapses, - the assessment of quality of life (scale EuroQL-5).Expected Results: TRANSREG will define which patients respond to IL2, whether per pathology or according to pre-treatment phenomics, allowing to guide further clinical development of low dose IL2 in autoimmune and auto-inflammatory diseases.
|Ages Eligible for Study:
|18 Years and older
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- age > 18 year
- male or female
- documented diagnosis of one AIID among the 11 diseases selected (following consensual specific criteria)
- stable or moderately active disease under standard treatment (≥ 2 months) at the time of inclusion,
- normal thyroid function (with or without treatment)
- effective contraception for more than two weeks at inclusion and negative beta HCG test for women of childbearing potential,
- affiliated to the social security system
- written informed consent form.
Exclusion Criteria:
- known intolerance for IL2 (see SPC),
- administration of a non-authorized treatment and/or IV bolus of corticosteroids in the last 2 months,
- vaccination with live attenuated virus in the months preceding the inclusion or planned during the study
- other severe or progressive autoimmune/inflammatory pathology,
- low white blood cell count<2000/mm3, lymphocytes <600/mm3, platelets <80 000/mm3,
- heart failure (≥ grade III NYHA), renal insufficiency (Cockcroft< 60ml/mn except patients with lupus or Wegener's granulomatosis) or hepatic insufficiency (transaminases> 5N except for patients with autoimmune hepatitis), or lung failure,
- significant abnormality in chest X-ray other than these linked to the diseases under investigation
- cancer or history of cancer cured for less than five years (except in situ carcinoma of the cervix or basocellular carcinoma)
- poor venous access not allowing repeated blood tests,
- restrictive diet or parenteral nutrition,
- surgery during the last 2 months or surgery planned during the study,
- participation in other biomedical research in the last 3 months or planned during the study.
- pregnant or lactating women,
- concomitant psychiatric disease or any other chronic illness or drug-abuse that could interfere with the ability to comply with the protocol or to give informed consent,
- positive HIV serology, active hepatitis B or EBV infection,
- patients under a measure of legal protection
Please refer to this study by its ClinicalTrials.gov identifier: NCT01988506
|Contact: David KLATZMANN, MD, PhD
|+33(0) 1 42 17 74 61
|Contact: Roberta LORENZON, MD
|+33(0) 1 42 17 74 61
|Service de Médecine Interne - Hôpital PITIE SALPETRIERE
|Paris, Ile de France, France, 75013
|Contact: Patrice CACOUB, MD, PhD 33 1 42.17.80.09 email@example.com
|Principal Investigator: Patrice CACOUB, MD, PhD
|Service d' Hépato Gastro Entérologie - Hôpital SAINT-ANTOINE
|Paris, Ile de France, France, 75012
|Contact: Olivier CHAZOUILLERES, MD, PhD 33 184.108.40.206.78 email@example.com
|Principal Investigator: Olivier CHAZOUILLERES, MD, PhD
|Service de Dermatologie - Hôpital COCHIN
|Paris, Ile de France, France, 75014
|Contact: Salim Aractingi, MD, PhD + 33 1 56 01 64 62 email@example.com
|Principal Investigator: ARACTINGI Selim, MD, PhD
|Service de Gastro Entérologie - Hôpital SAINT-ANTOINE
|Paris, Ile de France, France, 75012
|Contact: Laurent Beaugerie, MD, PhD 33 1 .22.214.171.124 firstname.lastname@example.com
|Principal Investigator: Laurent BEAUGERIE, MD, PhD
|Service de Rhumatologie - Hôpital PITIE SALPETRIERE
|Paris, Ile de France, France, 75013
|Contact: Bruno FAUTREL, MD, PhD 33 1 .220.127.116.11 firstname.lastname@example.com
|Principal Investigator: Bruno FAUTREL, MD, PhD
|Service de Rhumatologie - Hôpital SAINT-ANTOINE
|Paris, Ile de France, France, 75012
|Contact: Francis Berenbaum, MD, PhD 33 1 .126.96.36.199 email@example.com
|Principal Investigator: Francis. BERENBAUM, MD, PhD
|CIC - Hôpital PITIE SALPETRIERE
|Paris, Ile de France, France, 75013
|Contact: Roberta LORENZON, MD 33 1 .220.127.116.11 email@example.com
|Principal Investigator: Nathalie Nicolas, MD
|Centre Hépato-Biliaire - Hôpital Paul Brousse
|Not yet recruiting
|Villejuif, Ile de France, France, 94800
|Contact: Jean-Charles DUCLOS-VALLEE, MD, PhD 33 1 45 59 64 33 firstname.lastname@example.com
|Service de médecine vasculaire - HEGP
|Not yet recruiting
|Paris, France, 75015
|Contact: Emmanuel MESSAS, MD, PhD 33 1 56 09 22 89 email@example.com
|Principal Investigator:
|David KLATZMANN, MD, PhD
|Assistance Publique - Hôpitaux de Paris
No publications provided
|Responsible Party:
|Assistance Publique - Hôpitaux de Paris
|ClinicalTrials.gov Identifier:
|NCT01988506 History of Changes
|Other Study ID Numbers:
|Study First Received:
|November 7, 2013
|Last Updated:
|September 4, 2015
|Health Authority:
|France: Ministry of Health
Keywords provided by Assistance Publique - Hôpitaux de Paris:
Interleukin 2,
Auto-immune disease
Inflammatory disease
Regulatory T cells,
Immune tolerance
Additional relevant MeSH terms:
Wegener Granulomatosis
Aortic Arch Syndromes
Arthritis, Rheumatoid
Behcet Syndrome
Cholangitis, Sclerosing
Colitis, Ulcerative
Crohn Disease
Hepatitis, Autoimmune
Lupus Erythematosus, Systemic
Spondylitis, Ankylosing
Takayasu Arteritis
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Aortic Diseases
Autoimmune Diseases
Bile Duct Diseases
Biliary Tract Diseases
Bone Diseases
Bone Diseases, Infectious
Cardiovascular Diseases
Colonic Diseases
Connective Tissue Diseases
Digestive System Diseases
Eye Diseases
ClinicalTrials.gov processed this record on October 13, 2015


text:
Building on Paul Campos' points, law professor Jason Solomon notes another problem with the excessive number of law students – the Income-Based Repayment (IBR) program gets more expensive for taxpayers:
[M]ost recent law graduates, for now and the foreseeable future, will be on IBR soon, if they aren't already. Their loan payments will be capped, but as a result, they won't even be keeping up with the interest accruing on the loan. These payments will provide the gov't some additional revenue in the short-term, but in 20-25 years, there's going to be a debt on Uncle Sam's books for each student for hundreds of thousands of dollars of principal and unpaid interest. When that gets "forgiven," it just means the cost gets transferred to the taxpayers, adding to the deficit.
Steven Davidoff argues that one possible solution – lowering the cost of law schools – is not as easy as it might seem.


text:
Release date: 16/4 2012
SLN 011 (Selective Notes/Razzia)
1. There Is Something Wrong in Your Head. Your Brain Is Dead.
2. Enough! We Demand The Abdication.
3. Problems With The Six Feet Under?
4. My Best Friend Stole My Privacy And Gave It Away to Facebook. I'm In Chock!
5. We Are Never Coming Out Again
6. Me, My Psycologist and Everyone I know
7. It's Now Official: We are Alive Underground
8. I Fought My Reputation And Lost and Now It's Stuck For Good
9. Bob Hund; Will You please give me your autograph you can write it on my right arm just below my tribal tatoo
10. Bring me the fucking riot...man it's gonna take you higher...man RIP
More info here


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mainstream print and electronic media regularly use "capitalism" to refer to "the economic system we have now." And it's relatively common to hear "capitalism" employed as a synonym for "dominance of workplaces and society by capitalists—by the owners of substantial capital assets." Libertarian principles as I understand them entail support for capitalism in neither of these senses.Read more »
When the pilgrims first came to America they almost all starved to death because they adopted communal agriculture. How the pilgrims saved themselves was to adopt the primary prerequisite for a capitalism economy, private property. Mayflower pilgrims had a system in which all goods were owned by the community. All produce was in a common store, from which each individual would receive equal ration regardless of how much he had contributed. The colony was unable to produce enough food until individuals traded with Indians and fellow Pilgrims.Read more »
In a boost to animal welfare activists looking to get livestock out of cramped cages, Burger King will be the first major U.S. fast-food chain to give all of its chickens and pigs some room to roam.
On Wednesday, the world's second-biggest burger chain pledged that all of its eggs and pork will come from cage-free chickens and pigs by 2017, hoping to satisfy rising consumer demand for humanely produced fare and increase its sales in the process.
It is ironic that Occupy Wall Street is reportedly very low on cash. This is something that Wall Street itself never has to worry about. They have ready access at all times to as much cash as they need. The Occupiers mistakenly blame capitalism, but it is not capitalism that is behind this inequity. It is the completely anti-capitalist Federal Reserve System.Read more »
Ryan McMaken of the Mises Institute superbly exposes the US Chamber of Commerce for their crony capitalism, explains how Ron Paul is the true defender of free enterprise and refers to Bastiat's great exposé on the Seen and the Unseen.Read more »
In "Why America Failed", left-wing historian and cultural critic Morris Berman's postmortem of America, the author concludes that our inevitable end was literally woven into the American DNA, dooming the country from the start. It isn't just the American Dream that has failed claims Berman, but America itself, because the dream -- the individual accumulation of wealth -- was a mistake in the first place.Read more »
People always seem to say that Capitalists are greedy. This tale proves the exact opposite to me! That Capitalism, in it's truest form, allows people to compete so they can engage in charitable acts in the future. How many people would be able to donate to charities if there were no Capitalism?Read more »
High quality global journalism requires investment. Please share this article with others using the link below, do not cut & paste the article. See our Ts&Cs and Copyright Policy for more detail. Email email@example.com to buy additional rights. http://www.ft.com/cms/s/0/f7f9bdfc-3204-11df-a8d1-00144feabdc0.html#ixzz...Read more »
"Fight of the Century" is the new economics hip-hop music video by John Papola and Russ Roberts at http://EconStories.tv.Read more »
Do you really need a 4.0 GPA? Isn't that GPA kind of—I don't know—excessive? Wouldn't life at your college be fairer and more just if you gave some of your unneeded grade points to another student—a less privileged student—who's flunking Intro to Psych?Read more »
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Jacksonville, FL -- (SBWIRE) -- 05/12/2014 -- General contractor from jaxsharksgc.com points out how home improvement services are of great importance to people, who want to ensure comfort for their loved ones and add value to their homes as well.
Smarter Investment Corp has now brought these services to home owners in Jacksonville, Jacksonville Beach, Ponte Verde Beach, Atlantic Beach and St. John's, Florida. The company is known to be a Certified General Contractor in the area and it can handle a wide array of services from kitchen remodelling to bathroom ideas and room additions as well.
Home Improvement can involve all these aspects of people's homes and a lot more. There are those who have moved into homes, keeping in mind their budget constraints. But they would like to make changes to their homes now so that they are exactly according to their tastes. The company offers them services that claim to keep their needs and personal tastes in mind so that their home turns out to be exactly according to their vision.
Home Improvement projects also make sense for those who want to add value to their homes. By making one's house more state of the art and equipped with latest amenities, and ensuring that it is smartly designed can make a big difference to a value of a home. The professionals working with the company understand that and hence offer solutions to people that suit their requirements for the T.
Smarter Investment Corp has managed to gain expertise in different areas of home remodelling and improvement. Some of them include framing and flooring, which is just what one might be looking for. Home owners can also make the most out of kitchen remodelling or services for additions like bedrooms, game rooms to make their spaces more livable, according to their needs.
The company also handles renovation services, which might be the need of the day for several home owners. Property preservation and Tenant Build-outs, which also involve plans and permit approvals, are some of the other areas where the company holds its forte. It takes all these aspects of home improvement into account before offering convenient and cost-effective solutions to its customers.
About Smarter Investments Corp
Smarter Investment Corp is an award winning and Certified General Contractor in the area with 13 years of experience. It has won the 2007 Entrepreneur of the Year Award from the Hispanic Business Magazine and Preservation Award from the Historic Preservation Society of Jacksonville.
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URL: http://jaxsharksgc.com
Email: firstname.lastname@example.com
Address: Fabian Videla, Smarter Investments Corporation, 2404 Hawkcrest Dr E Jacksonville, Fl 32259. United States.
Phone: +1 904-647-2340


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Is there any policy on GetACoder to guarantee payment for a job?
How does payment work on GetACoder?
What is the difference between the milestone payment and the hourly payment?
How much will I earn as a Provider on GetACoder?
What are the payment options available on GetACoder?
What is the pay rate charged by GetACoder?
When do you collect the fee?
If I work more than scheduled on an hourly job will I get compensation?
In fixed-price jobs, can I receive a partial refund on the commission charged if I don\'t invoice the buyer the entire bid amount?
How long does it take to receive a withdrawal from GetACoder?