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G.Skill Phoenix PRO 120GB SSD review -
Installation and experiences - life-span recommendations
Installation and recommendations
Installation of an SSD drive is no different than installing any other drive. Connect the SATA and power cable, and you are good to go. Once you power on that PC of yours, the first thing you'll notice; no more noise. That by itself is just downright weird opposed to the old fashioned spinning platters on an HDD.
My system boot drive many moons ago was a WD Raptor and when that HD is crunching, you know the HDD is alive alright. That's just no longer a reality. You will look at the SSD wondering "is that thing even working?", while the Windows 7 logo has already appeared on your monitor.
So no more purring and resonating or other weird noises. Completely silent, I like that very much.
The second factor you can rule out is heat. Modern day HDDs tend to get hot, or at the least quite warm. When not cooled down they can reach 40-50 Degrees C pretty easily. No worries though as the HDD can handle it, yet the SSD remains completely cool to lukewarm. Most SSD drives will get to roughly 28-30 Degrees C.
Then there's that first boot up on the SSD, weird .. it's fast .. really fast. That's where you'll get the first smile on your face. But let's talk about taking some precautions, remember this is an MLC based drive, we want it to last at least ten years right?
SSD life-span recommendations
Drive wearing on any SSD based drive will always ghost in the back of your mind. Here are some recommendations and tips for a long lifespan and optimal performance. Basically, what is needed is to eliminate the HDD optimizations within Vista (that cause lots of small file writes like superfetch and prefetch), things like background HDD defragmentation (that causes lots of small file write drive activity). In short (and this is for Vista and Windows 7):
- Drive indexing disabled. (useless for SSD anyway, because access times are so low).
- Prefetch disabled.
- Superfetch disabled
- Defrag disabled.
So make sure you disable prefetchers. Also, especially with Vista and windows 7, make sure you disable defragmentation on the SSD disk. You do not have a mechanical drive anymore so it is not needed, let alone you do not want defragmentation to wear out your drive, and Vista does this automatically when your PC is in idle (picking it's nose).
Don't get me wrong though, you could do a defrag without any problems, you just do not want that to be regular.
For Superfetch/prefetchers and other services, at command prompt just type: services
Use Windows 7 / Vista's services to disable them. To disable defragmentation:
Windows 7 and Vista Automatic Defrag:
1. Click Start
2. Click Control Panel
3. Select the Control Panel Home
4. Click System and Maintenance
5. Under the Administrative Tools section at the bottom, click Defragment your hard drive
6. You may need to grant permission to open the disk defragmenter
7. Click or unclick Run automatically (recommended) depending on if you want this feature enabled or disabled.
8. Click OK
OR alternatively at the Vista start prompt just type : dfrgui
Now over time your SSD will get a little fragmented. Simply do manual defragment folks; the difference between daily automated defragmentation or doing it yourself once a year .. is a big big difference.
Apply common logic and sense, always. And good news, Windows 7 will have many improvements and tips like shown above already automatically setup for you.
Windows 7 and the SSD TRIM feature
Windows 7 and Windows Server 2008 R2 support the TRIM function, which the OSs use when they detect that a file is being deleted from an SSD.
When the OS deletes a file on an SSD, it updates the file system but also tells the SSD via the TRIM command which pages should be deleted. At the time of the delete, the SSD can read the block into memory, erase the block, and write back only pages with data in them. The delete is slower, but you get no performance degradation for writes because the pages are already empty, and write performance is generally what you care about.
Note that the firmware in the SSD has to support TRIM, but the good news is that firmware updates are coming out for many SSDs to add TRIM support.
TRIM only improves performance when you delete files. If you are overwriting an existing file, TRIM doesn't help and you'll get the same write performance degradation as without TRIM.
The OCZ Vertex 2 is TRIM compatible.
Enable AHCI
The last tip we want to give you to gain a little extra performance boost is that you enable AHCI mode. AHCI mode can help out greatly in performance for SSDs. Now, if you swap out an HDD for an SSD with the operating system cloned and THEN enable AHCI in the BIOS, then you'll get a boot error / BSOD.
The common question is, is there a solve for this ?
To answer that question (and as we do safely with all modern chipsets) there is a way to safely enable AHCI mode. Here we go:
1. Startup "Regedit
2. Open HKEY_LOCAL_MACHINE / SYSTEM / CurrentControlset / Services
3. Open msahci
4. In the right field left click on "start" and go to Modify
5. In the value Data field enter "0" and click "ok"
6. exit "Regedit"
7. Reboot Rig and enter BIOS (typically hold "Delete" key while Booting)
In your BIOS select "Integrated Peripherals" and OnChip PATA/SATA Devices. Now change SATA Mode from IDE to AHCI.
You now boot into windows 7 or Vista, and the OS will recognize AHCI and install the devices. Now the system needs one more reboot and voilla .. enjoy the improved SSD performance.
G.Skill designed another 8GB low voltage DDR3 kit (2x 4GB) that can be set at 1600 MHz yet still run a CAS latency of 7. And that is truly interesting because the denser the ICs get, the higher latency typically gets.
G.Skill 2x4GB CL7 1600 MHz Trident DDR3 review
We feel that more memory is rather important, and in that trend memory manufacturers have started to increase the density of DIMM modules. Where 1 and 2GB DIMM modules have been the standard, we now see very good progress in 4 GB DIMM modules. Today we\'ll do things a little different, G.Skill designed a 8GB low voltage DDR3 kit (2x 4GB) that can be set at 1600 MHz yet still run a CAS latency of 7. And that is truly interesting because the denser the ICs get, the higher latency typically gets.
G.Skill Flare DDR3 2000 MHZ C7 AMD kit review
We test and review the G.Skill Flare DDR3 2000 MHZ C7 AMD kit. These kits are optimized for AMD platforms preferably with the new six-core X6 processors, and in specific some ASUS motherboards. The kit we'll be testing today obviously comes from that series and is a 2,000MHz CL7-9-7-24 1.65V 4GB (2GBx2) DDR3 kit with its latest Flare heatsinks.
G.Skill Phoenix PRO 120GB SSD review
The SSD tested today once again is the Phoenix series from G.Skill. After we tested their 100GB Phoenix SSD (which received a very positive review) G.Skill instantly requested if we would like to review the 120GB PRO model. Both drives pretty much are the same thing, same controller ... The 100GB Phoenix uses Samsung memory though but the trick is that there is 20GB extra volume space available on the new 120GB Pro (compared to the 100GB model) for nearly the same price. A new Firmware for the SandForce 1200 based controller that is inside this 120GB model simply reserves less NAND flash memory for its data-compression scheme. As a result the overall write performance could be a tiny bit slower, but only a few percent as best. It however will give you 20 GB more space to play around with at the same price. And since price per GB is everything in the land of SSDs -- this certainly is a significant for any vendor and for you as an end-user.


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Content Filter Symantec Web Gateway
Hi everyone,
I have a questions, because I have SYMC PROTECTION SUITE ENTERPRISE EDITION 4.0 PER USER INITIAL ESSENTIAL license but in Symantec Web Gateway Content Filter option is "Not Licensed". I know that I need another .slf file but the question is if in my license it's available.
Best regards.
Comments 4 Comments • Jump to latest comment
Best Bet you can contact symantec licensing team for better answer.
Thanks In Advance
Ashish Sharma
The Protection Suite only includes the SWG license for Antivirus and AntiSpyware scanning. The URL filtering option is a separate license, and must be purchased separately.
See the "Add-On" section of the SWG product page: http://www.symantec.com/web-gateway/agents-options-add-ons
No probs.
As always, it'd be appreciated if you could mark any posts you find useful with a "Thumbs Up" or as the Solution

subset: commoncrawl


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*NSYNC member Joey Fatone has denied the rumours that the boyband will perform at the 2013 MTV Video Music Awards on Sunday.
Justin Timberlake will be receiving the Michael Jackson Vanguard Award at the ceremony leading to speculation that the boyband will share the stage together to mark the occasion.
Joey Fatone was seen landing at a New York airport today – the same city the VMAs are being held – but told TMZ he was in town for his cousin's surprise 40th birthday.
When asked if the *NSYNC will be performing at the ceremony, Joey asked, "Why the hell would I attend?", but displayed a cheeky grin on his face whilst talking to reporters. Is he trying to keep the reunion a surprise?
Joey Fatone denies he will be performing on stage with Justin timberlake and the rest of *NSYNC at the VMAs on Sunday. (WENN)
But perhaps *NSYNC fans shouldn't get their hopes up as Joey, 36, claimed that he wouldn't be performing as he no longer has a close relationship with his former bandmate Justin Timberlake.
"As far as I know. I haven't gotten a phone call or anything," explained Joey. "Just like his wedding, I didn't get the phone call or the invite."
*NSYNC bandmate Lance Bass also downplayed rumours of an reunion on his radio show earlier this week.
It looks like we will have to tune into the MTV Video Music Awards on Sunday, August 25 to find out if Joey and Lance are telling the truth.


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Mehdi Hasan exposes misconceptions about the continent
Explore Japan through its offbeat train culture
22 Mar 2014 12:39 GMT | Politics, Europe, US & Canada, Russia, Ukraine
Thousands of people celebrated in the Crimean capital of Simferopol after the region broke away from Ukraine and was formally accepted into the Russian Federation.
Celebrations continued into early Saturday, hours after President Vladimir Putin signed a treaty making Crimea part of Russia. Fireworks burst in the sky in Simferopol as the Crimean prime minister, Sergei Aksyonov, addressed the crowds.
"I am sure that we all together will live in a new Crimea happily, we will live the way our fathers and grandfathers wanted us to live as we dreamed. This is fair and we deserved it. Happy holiday, dear friends," he said.
I am sure that we all together will live in a new Crimea happily.
Sergei Aksyonov, Crimean Prime Minister
The celebrations were timed to coincide with a similar event taking place in Moscow, where fireworks also lit up the skies.
During his visit to Ukraine on Saturday, Germany's foreign minister Frank-Walter Steinmeier denounced Russia's "attempt to splinter Europe" for its action in Crimea.
"The referendum in Crimea... is a violation of international law and an attempt to splinter Europe," Steinmeier said after meeting Ukraine's acting president Oleksandr Turchynov.
As this developed, an international team of monitors is being sent in to Ukraine's eastern region, where tensions continue to brew between supporters and opponents of Russia.
The team from the Organization for Security and Co-operation in Europe [OSCE] will begin its work after Russia dropped its objections. But there is disagreement on whether they will be allowed in to Crimea itself.
A military transition is also underway as Russia takes over bases across the Black Sea Peninsula, raising its national flag as Ukrainian soldiers departed on their trucks.
On Friday, all 155 senators present in Moscow's upper house of parliament voted in favour of the treaty of accession.
In Brussels, the acting prime minister of Ukraine, Arseniy Yatsenyuk, signed an association agreement with the European Union.
"This is a historic day for my country, and we believe this is a historic day for the entire Europe," Yatsenyuk declared after signing the agreement. "We want to be a part of a big European family."
Appeal for diplomacy
In the Ukrainian capital of Kiev, UN Secretary General Ban Ki-moon called for more diplomatic efforts to stop the crisis from further escalating.
Meanwhile, the head of Ukraine's border guards has visited one of the new defensive positions on the border with Russia. He said troops there were tasked with stopping provocateurs from Russia from entering Ukraine.
The US has said it is wary of Russian assurances over military exercises near the border.
As alliances were made, the EU and the US also announced new sanctions against prominent Russians, including close allies of Putin.
Moscow had announced its own sanctions against senior US politicians in retaliation against visa bans and asset freezes imposed by Washington on its citizens.
Source: Al Jazeera and agencies
Yurii Klymenko tells fellow diplomats Russia is eyeing full blown military intervention in the east and south.
Politics, Europe, US & Canada, Iran, Russia
Crimean "self-defence" forces overtake Sevastopol base without violence and raise Russian flags at the gates.
Politics, Europe, Russia, Ukraine
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Education Pro enables teachers to monitor students' online activity and sends "violation" alerts over trigger terms.
Human Rights, Education, United Kingdom
Japanese protesters invoke human rights abuse and painful memories of war to oppose US Marine airbase on their island.
Military, Human Rights, Japan
Precarious peace agreement has failed to end fighting in South Sudan with fears of famine and disease outbreaks.
War & Conflict, Human Rights, South Sudan
While targeting 'terrorists and junkies', Kremlin-backed strongman Kadyrov flaunts the law to safeguard moderate Islam.
Human Rights, War & Conflict, Chechnya
Defiant Syrian leaders tells Iranian TV that US-lead coalition against ISIL has failed, as Moscow ramps up bombings.
War & Conflict, Middle East, Syria, Syria: Broken Nation, Syrian crisis
Armed group says it controls most parts of city after it was briefly taken by government forces backed by US strikes.
War & Conflict, Middle East, Afghanistan
101 East follows the lives of seven people in Nanjing and asks what they think of the direction their country is taking.
Politics, Asia Pacific, China
In a Delhi slum, puppeteers, musicians, jugglers and acrobats try to unite as they wrangle with an approaching eviction.
Business & Economy, Arts & Culture, Poverty & Development
An investigation into the high rate of child sex abuse in Jamaica and the government's failure to protect its children.
The story of the 1994 Rwandan genocide told through the prism of the media, exploring their role then and today.
Media, War & Conflict, Africa


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Bargain Basement for Brainiacs - Sacramento area community musical theater (esp. DMTC in Davis), liberal politics, Kylie Minogue, SW meteorology, hurricanes, Australian bits, "Breaking Bad" filming locations reference site, and general weirdness.
Thursday, April 28, 2011
Albuquerque Slang
Michelle S. pointed this out on Facebook. Some of the slang is fairly-new. I've heard 'Spaghetti Bowl' used for the enormous and confusing Hwy 95/I-15 interchange in Las Vegas, but not for the smaller Big-I in ABQ. Someone who's been in both places simply applied the same term, probably after recent Big-I remodeling, and it's sticking. 'Burque' is new to me (resembles burka, so probably from last decade). My synonym is 'Albuturkey', but so far that isn't sticking. Hadn't heard 'Tamalewood', but it doesn't surprise.
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Carnival of Healing #96
July 28th, 2007 by Cindy Hebbard
It seems so much easier to keep oneself healthy and fit in the summertime than it is once winter sets in. During the warm summer months, we tend to be more active, eat more fresh foods and be exposed to more fresh, outdoor air.
The stifling heat of summer is another story. We know that we should take it easy when it's hot and humid, and that we should be very diligent about drinking enough water, although not enough of us do. I hope you're doing what you can to experience a balanced body, mind and spirit, wherever you may be.
Let's go on to the wonderful blog posts and articles included in this week's Carnival of Healing.
We begin this edition with Raymond David Salas' fine article about a truly potent and safe way to help alkalize the body. The Benefits of Celtic Sea Salt is posted at ZenChill Power Tools Blog. Here's another simple way to take in electrolytes and trace minerals to help keep the body's fluids in balance during extreme heat.
A brilliant collection of valuable resources may be found in Kevin Bedell's A simple step you can take: Eat more locally grown food posted at 21st Century Citizen. This is truly a key piece of the solution to better health for ourselves, our families, communities and our beautiful planet.
Do you work at a desk? Are you wanting to take off a few nagging pounds around the middle or from your thighs? Has Dianne M. Buxton got the answer for you! Healthy Office Space Workoutsis one of the most brilliant and practical ideas to come down the path in a long while! Find it posted at manifestingsuccess and enjoy!
Craig Harper is simply delicious! Reading any of his posts is as good as a hot fudge sundae made from organic ice cream! Life Beyond the Physical… Exploring the Oogabooga (part one) will likely tickle you in places you forgot were there. Find this and so much more at Motivational Speaker – Craig Harper.
Mary Kearns suggests we Park It the next time we have a free afternoon or want to get away for the weekend. After all, the US is a vacation deprived nation, and our national parks are an amazing resource and they make the perfect setting for nurturing our minds, bodies and spirits. Check out Becoming Your StellarSelf.
My entry, found here at Wisdom of Healing, is a recipe for daily detoxification and yummy, easily utilized nutritional foods blended into a smoothie. Energy Drinks, Delicious and Green! gives you dozens of healthy options to combine to your taste or needs. I hope you enjoy these as much as many of my students have.
Alvaro Fernandez brings to our attention how science is 'proving' what we know in our hearts to be so; gratitude is good for us. Please check out Mental Training for Gratitude and Altruism, found at Brain Health Blog.
edithyeung addresses all those folks, young or mature, who are now awakening to the reality that the mundane life of a typical western citizen is not truly satisfying (no matter how much stuff we may collect), and it's not what we're really here for. How to Find Your Greatness (Inspired by Barbara DeAngelis) a simple personal growth assignment for those who choose to find meaning and purpose in life, may well change your life! You will find it posted at Edith Yeung.Com: Dream. Think. Act.
I love everything I've read from Aparna. (I must meet you!) Fenugreek (methi) for health and beauty is a delightful list of simple and practical uses for a spice that most of us have in the cupboard, but we have no idea how to use it. You may find this and other great lists and articles posted at Beauty and Personality Grooming.
Debra Moorhead gives us a reminder about the importance of Recharging Your Batteries to nurture the spirit and improve performance. Find it at Debra Moorhead . com.
therapydoc is always entertaining and thought provoking; an excellent therapist I am certain. Todays topic, Can You Cry Too Many Tears?, is a relevant question for many, and may be found posted at Everyone Needs Therapy.
Eric presents us with valuable information for outdoor enthusiasts everywhere in How To Relieve the Pain of a Bee Sting in Under 30 Seconds posted at Husbandhood. Thank yous are coming to you from parents everywhere, Eric, I am sure.
Craig J. Phillips tells us a very personal and deeply emotional story of his recovery from a traumatic brain injury resulting from a childhood car accident and his ability to overcome adverse attitudes and circumstances in My Journey thus Far, found at his site Second Chance to Live.
Tupelo Kenyon brings up how important it is to Take Time for You so that you may do your best to give care for others. It's posted at Tupelo Kenyon.
Cade Krueger suggests that Mixing Up Your Exercise relieves boredom. It's found at Write To Right Your Home Based Business Opportunity.
Patricia Singleton says "I wrote this about that magical, mystical part of myself that wants to heal herself, me and the world…" in Keeper Of My Creativity, posted at Spiritual Journey of a Lightworker.
Karen Halls presents a checklist so that you may better choose The Best Drug Treatment Programs and Drug Addiction Treatment, posted at Addiction Recovery Blog.
Jimmy Atkinson gives us 12 Reasons Medical Tourism Is So Popular | Medical Tourism Guide, posted at Medical Tourism Guide.
Certainly a lot of great information for you here! I hope you've enjoyed it. Please access the
Carnival of Healing archives, or visit last week's carnival at Debra Moorhead . com and next week's carnival at Wellness Through Wisdom. Have a good week!
6 Responses to "Carnival of Healing #96"
on 29 Jul 2007 at 1:02 pm Craig J. Phillips MRC, BA
Hi Cindy,
Thank you very much for including my post, My Journey thus Far in your Carnival. I am truly honored by your kindness.
Have a simply phenomenal day
Craig J.Phillips MRC, BA
Second Chance to Live
on 02 Aug 2007 at 10:06 pm Husbandhood
Hey thanks for all the work. The carnival looks great. Its nice to see that you've actually took the time to read the posts. Good Work.
on 03 Aug 2007 at 11:09 pm Patricia - Spiritual Journey Of A Lightworker
Cindy,thanks for including my article in your blog carnival. I just checked to see if the carnival was posted yet. I wasn't expecting it to be out until August 4. I guess I have a lot of reading to catch up. I enjoy reading all of the articles of the Carnivals that I participate in.
on 05 Aug 2007 at 1:24 am Aparna
Thanks for including my article and also for the kind words about my blog. I simply love your style of writing.
on 24 Mar 2008 at 2:42 pm medretreat
Thanks for the info!
on 26 Mar 2008 at 4:05 pm MedRetreat
Thanks for this excellent information!


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Select Local Merchants
Tone Productions Dj ServicesRead MoreTone Productions Dj Services extends the heartiest of welcomes to you for their ongoing season of theater in Oak Lawn. If you've worked up an appetite, no worries! This theater also has a fabulous restaurant. Parking is plentiful, so visitors can feel free to bring their vehicles.9734 Southwest HighwayOak Lawn, IL US
Country Club Hills TheaterRead MoreCome and see the theatrical offerings at Country Club Hills Theater in Country Club Hills. If a bite's all you're after, then you'll want to stop by this club for a delicious fill of their home-cooked food. Surround yourself with the wonderful weather at your next night out at Country Club Hills Theater. Those hoping to avoid the weekend rush will do best visiting the club during the week. Don't spend time searching for parking — visitors are welcome to use the adjoining lot.4116 183rd StreetCountry Club Hills, IL US
Buzz BombRead MoreAll the world's a stage, but Buzz Bomb in Bedford Park offers the best shows around. Buzz Bomb is not only a restaurant, it's also a bar. The doors are open for you at this theater with their people friendly restaurant and great, home-cooked food. Guests can migrate to the bar section to catch the game on the TV. Buzz Bomb will be able to accommodate your large party. Our establishment serves up a wide variety of beverage options, including wine, liquor and beer. Get down with a live DJ while dining and have some fun on the theater dance floor. Reserve your table ahead of time if you're heading over to the theater on a Friday and Saturday — it can get quite crowded during the weekend. Drift away from stuffy dress-code conventions and dine in comfort at Buzz Bomb. Store your car in a nearby lot or pass it off to the valet service at Buzz Bomb.6301 W 73rd StBedford Park, IL US
Connection BandRead MoreStart a night out with your friends right at the terrific theater at Orland Park's Connection Band. Pick up a tasty meal at their restaurant, located conveniently within the theater. Little ones are just as welcome as their parents at this theater. Parking is plentiful, so visitors can feel free to bring their vehicles.14622 Creekview DrOrland Park, IL US
Carl Linden Strolling ViolinsRead MoreWhen life simply isn't dramatic enough, Munster's stage shows at Carl Linden Strolling Violins are for you. Parking is plentiful, so patrons can feel free to bring their vehicles.8772 Monroe AveMunster, IN US
Another Hole In The WallRead MoreAre you ready for unforgettable moments of theater? If so, then Another Hole In The Wall in Steger has all the shows for you. With a sizzling plate of terrific food, this theater boasts among the best eats this side of the city. The theater can get tied up on the weekends, so allow yourself time to wait for a table. Parking is plentiful, so guests can feel free to bring their vehicles.3236 Union AvenueSteger, IL US


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About Hart's
One of Nottingham's finest dining establishments, Hart's restaurant maintains a focus on delivering superb cuisine and excellent service in a modern, contemporary and comfortable environment.
The modern British cuisine places great emphasis on simple but fantastic, fresh ingredients. Why not take a look at our fabulous menus?
Full capacity in the restaurant is 88 people at any one sitting and 14 in the private dining room. Our turnover of diners per night is 140 people.
Opening Times
Lunch 12 noon to 2.00pm (Last Orders) During Graduation lunch reservations will be taken until 3.15pm
Dinner 7.00pm to 10.30pm (Last Orders)
7.00pm to 9.00pm (Last Orders on Sundays)
Pre-theatre supper 6.00pm
If you are looking for somewhere to hold a private celebration, wedding or business function Hart's Upstairs is the solution. Located above our main restaurant, Hart's Upstairs provides you with one of the city's best facilities for conferences, meetings, seminars and parties.


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I am old fashioned (no wheres close to a feminist) and have a hard time paying because if a man is serious about getting to know me he will pay for all access. Plus, I grew up in a house where my dad provided and my mom either worked, volunteered or took care of us.
When I first entered the Jewish frat in college I was harassed for wearing a cross around my neck. I played that I was Jewish because my last name can pass for it. Later, I told my now friends that I am spiritual but not Jewish or Christian. However, after dating many Jewish guys unknowingly I joked about making a tee shirt "Will Convert for the *Right* Jewish Guy". I now own it (a couple years later) and wear it proudly! ) I am a young entrepreneur. I enjoy everything from a quiet romantic night at home to a hot dance club in Vegas. I love to travel, meet new people, and dance. I enjoy fashion, culture, romance, water sports, smiling and helping animals/kids.
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Any woman who has more than one child can tell you how different each child is from birth. You are born with your personality intact. The Color Code is based on your natural, innate personality type. Of course, people may change over time, but your Core Color will always remain the same.
Sometimes it is difficult to choose from the four options given, but there is usually one that fits better than the rest, or at least one that you could see yourself as more so than the others. If you're still unsure, try asking someone who knows you well, such as a parent or sibling. They can give clarity on areas of your personality that you may not notice.


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Posted 06/17/2015 07:57:35 EDT
This lady has more issues than the Red Sox bullpen
Posted 06/17/2015 07:56:02 EDT
Red Sox won! Queue up the duck boats. Let's have a parade today
Posted 02/11/2015 08:34:44 EST
Posted 02/11/2015 08:29:34 EST
Before he retires and runs off to some warm destination, ask him if he has any experience running a public transit system
Posted 02/10/2015 09:54:33 EST
Is it true that he helped sew the first flag while having coffee at Betsy Ross' house?
Posted 02/10/2015 09:43:51 EST
Should have been upgraded to at least a Silverado or Tahoe
Posted 02/10/2015 09:41:51 EST
Stop worrying about salt on the roads and start worrying about all the accelerated tanning crap you are putting on your skin
Posted 02/09/2015 01:32:44 EST
The fact that James Franco won one, pretty much destroys any credibility the award had to offer.
Posted 02/05/2015 02:46:06 EST
Actually Pete, it was the BEST result of a call ever
Posted 02/05/2015 09:28:45 EST
I'll take ' How to quickly kill one's credibility' for $400 Alex
Posted 02/04/2015 04:33:47 EST
How do losers spend their time? Being jealous of the team that won the SB!
Posted 02/03/2015 01:55:06 EST
He's like a big ole lug. Someone that seems like they just enjoy life and raise people's spirits when he's around them.
Posted 02/03/2015 01:52:59 EST
Gisele wouldn't be caught dead in a Colorado. Give the truck to Butler's mom and buy the guy an Escalade!
Posted 02/03/2015 11:10:21 EST
As long as we beat Rex twice next year, I'll be happy.
Posted 02/02/2015 12:46:33 EST
Not a big deal. Half the Jets and Giants fans probably cannot read so they'll just be seeing the celebratory photos anyway
Posted 02/02/2015 12:39:41 EST
Glad they are holding this sooner than later so that the parade can take place when all of the Patriot organization members are able to be in attendance. If held on the weekend, half the folks will ha more »
Posted 02/02/2015 08:39:11 EST
and the Most Valuable Call goes to - Pete Carroll! Thank you! more »
Posted 02/02/2015 08:28:46 EST
I hope they washed Warner's fingerprints off that trophy before touching it. That d bag should never have been allowed to take that 5 minute trophy stroll down the field. And, Brady should give Butler more »
Posted 01/29/2015 04:30:28 EST
Gee Kurt, why so angry? Is it because HGTV did not invite you to tape another episode of holiday home design makeovers last season? more »
Posted 01/27/2015 03:38:32 EST
Oh My! I do hope all those Nantucket mansions survive through this storm. Wouldn't want the owners to not be able to use them for two weeks this year. more »
Posted 01/26/2015 09:51:44 EST
I still would bet that Harbaugh or someone associated with him was instrumental in creating this mess. He was embarrassed in the playoffs and doesn't seem like a person who would walk away quietly. An more »
Posted 01/26/2015 03:16:25 EST
As Welker's wife once said â6 kids 4 wives. Acquitted for murder. Paid a family off. Yay! What a hall of fame player! A true role model!" more »
Posted 01/26/2015 03:10:04 EST
I wonder if he's try performing another fake injury on Sunday more »
Posted 01/26/2015 08:42:05 EST
A few days from now we'll all forget about this storm and the focus will be on stocking up the pantry for the SB parties! more »
Posted 01/20/2015 10:47:27 EST
Hop on a plane and get out the heck of there? (after the Pats win of course). more »
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Wound Healing Kinetics of the Genetically Diabetic Mouse
With diabetes mellitus and obesity on the rise,1,2 and the increased prevalence of complex wounds and impaired healing,1,2 there is a crucial need to develop reliable wound repair models to identify effective therapeutic approaches.3,4
To be clinically relevant, an experimental model should appropriately reproduce the clinical situation physiologically and pathogenically.4 Experimental models can be either in vitro or in vivo.
In-vitro models are necessary in wound healing because of the orchestral fashion in which different cell types and the vascular and immune systems interact. In-vitro models are necessary in wound healing to study specific conditions, mechanisms of action, and the direct influence of therapeutics on individual cell types. Numerous in-vitro studies explore individual function and response to miscellaneous factors of cells such as keratinocytes,5,6,7–9 endothelial cells,10–12 fibrocytes,13–16 or molecules such as collagen,17 and many other components involved in wound healing. Additionally, in-vitro studies are often faster, cheaper, simpler, and more specific than in-vivo studies. In-vitro studies can also limit complications and variability.4
All findings derived from in-vitro studies have helped to elucidate important aspects of wound healing at the molecular level.
However, in-vitro studies often fail to reproduce the complexity of an organism and pathologic condition, making the in-vivo model a crucial tool for discoveries with clinical relevance to wound healing.
Researchers have studied in-vivo wound healing in a variety of species including pigs,18,19 rabbits,20–23 rats,24,25 and mice.2,4,26–32 The present review focuses on the mouse model, which has been instrumental throughout the development of the wound care field. Mice are appealing candidates for wound healing research because of their availability, low cost, and the ability to test a large number of animals in small facilities with highly reproducible results. In addition, the wide variety of knockouts and diseased mice available are important tools for the comprehension of wound healing mechanisms.
Wound repair kinetics vary among species. Mice, for example, heal mainly by contraction2,26,27,33 due to the presence of the panniculus carnosus muscle in the subcutaneous tissue. Humans lack this muscle and thus heal less through contraction and more through re-epithelialization—except in some areas where substantial wound contraction can occur, such as the joints.29
To generate a model that resembles human wound healing, researchers have developed ingenious models using wild-type mice and mice of various phenotypes including several diabetic mice, and have shown different levels of wound healing impairment. A phenotype similar to diabetes type 1 can be induced in mice by administering the cytotoxin streptozocin, which targets and inhibits proper pancreatic beta cell function.29 It has been reported that these mice have high variability in glucose levels,34 lower collagen synthesis resulting in reduced wound strength,35,36 less granulation tissue formation,37 altered T-cell function, and decreased macrophage phagocytosis.36
Other groups use the ob/ob mouse for wound healing research.35,38,39 The ob/ob mouse lacks the leptin gene causing high food intake and metabolic changes leading to obesity and resembles the type 2 diabetic phenotype.40,41 The ob/ob mouse appears to display impaired reproduction, hyperphagia, decreased thermogenesis,42 insulin resistance with secondary insulinemia,41 and impaired wound healing with decreased collagen accumulation.39,43,44 Topical and systemic leptin application in the leptin deficient ob/ob mouse increased wound healing, suggesting leptin has an impact in wound healing.44
The authors' group and others rely on the db/db strain.26,31,32,45–49 These genetically diabetic mice have a phenotype similar to diabetes type 2 that mimics the authors' target patient population. A homozygous point mutation on the leptin receptor gene (LEPR) in the hypothalamus changes the metabolic and behavioral phenotype of the db/db mouse.42,50,51 Lack of a functional central leptin receptor results in loss of a negative feedback signal critical to the normal control of food intake that causes a negative balance.42,50 The resulting physiologic responses lead to an early onset of diabetes and massive obesity (up to 3 times normal body weight, about 80% of which is fat) at 3 to 4 weeks of age.51 The mutant mice have impaired sympathetic nervous system activity,52 a lower body temperature (35˚C versus 37˚C when housed at room temperature), and lower thyroid hormone activity—all of which contribute to their reduced energy expenditure.42,53 Additionally, peripheral neuropathy through decreased numbers of epidermal nerves,53 myocardial disease,54–56 and impaired reproducibility,57 are present.
Mice homozygous for LEPRdb show significant wound healing deficiency compared to the wild type mouse and makes this genotype interesting for wound healing studies.26,31,32,45–49
Elevation in plasma insulin begins at 10 to 14 days, and blood sugar levels at 4 to 8 weeks.40 Although most actions of leptin are thought to be centrally mediated, some studies show leptin influences in the periphery.43,44,58–60 Some examples of leptin action outside the central nervous system include: inhibition of insulin release in pancreatic beta cells,60 stimulation of angiogenesis,61 proliferation of hematopoietic cells62 and effects, T-cell immunity,36 and stimulation of re-epithelialization.44 Dorsal excisional full-thickness skin wounds in the db/db mouse reached complete wound closure 7–10 days later than the wild-type mouse.26 Slower wound closure in db/db mice has been attributed mainly to impaired wound contraction, regardless of the initial wound size.26,32
The wild-type mouse has also been used to conduct wound repair studies. The strong tendency of wild-type mice to heal spontaneously, and the difficulties and limitations associated with this species for wound healing studies, have been reported in literature.26,27,29,32,33 Restrictions include: the high levels of contraction, re-epithelialization is almost impossible to capture over time, difficult to keep a dressing on the mouse during longer follow-up periods, and the fast re-growth of hair around the wound bed.32
To address these limitations, wild-type mouse models have been customized, which include a splint model to inhibit contraction.2,63 Researchers also developed more models by wounding different anatomical regions that are naturally unable to contract, such as the dorsum of the tail or the skull.33,64
In the authors' experience, the genetically diabetic mouse experimental model is one of the most suitable for use in wound healing studies. This model allows accurate quantification of the main aspects of a healing wound such as granulation tissue formation, collagen deposition, wound closure, re-epithelialization, and wound contraction. Given the epidemics of diabetes and its associated complications, the use of the diabetic mouse model will likely expand in the future, thus there is a need for a more accurate, reproducible development of this model.
Literature review. Three researchers independently conducted a literature review using PubMed to examine other diabetic murine models of wound healing. The keywords used to conduct this literature review were: db/db mouse, wound healing, wound closure, re-epithelialization, ob/ob, diabetic mouse model, wound contraction, wound re-epithelialization. The collected research was reviewed, and the methodologies and results were examined. All research used for comparison with the authors' db/db model had similar methodology: hair removal, acute full-thickness skin excision on the mouse dorsum, application of semiocclusive dressings, and macroscopic and microscopic measurements of wound closure.
Wound model and study design. Excisional wounds can be created in different sizes and shapes, and can either be left open or covered with a semiocclusive dressing.26,30–32,35,37,43,46,49,65 The follow up period is either defined or adjusted to complete wound closure. Depending on the histological read out, tissue harvest can be performed at the end of the follow up period or at earlier time points.
In the authors' studies, homozygous, genetically diabetic 8- to 12-week-old, db/db mice (strain C57BL/KsJ-LEPRdb) were used under an approved animal protocol in an AAALAC accredited facility. The day before surgery, hair was clipped and depilated (Nair®, Church & Dwight Co., Princeton, NJ). On the day of the surgery, animals were weighed and anesthetized with 60-mg/kg pentobarbital. Dorsal skin was marked with a standardized template (1.0 cm2 or 1.5 cm2) and skin plus panniculus carnosus was excised carefully. Tincture Benzodine Compound (Paddock Laboratories, Minneapolis, Minn) was applied at the surrounding skin and wounds were covered with semi-occlusive polyurethane dressings (Tegaderm™, 3M, St. Paul, Minn). Tegaderm dressing was changed twice a week and wounds were photographed from a standard high using a tripod. When taking pictures, animals were anesthetized with Isoflurane inhalation (Isoflurane, USP, NovaPlus, Lake Forest, Ill). On days 9, 10, and 21, or when wounds were completely healed, animals were euthanized and entire wounds were harvested including a surrounding 0.5-cm skin area. The wound was cut through the middle, and 1 piece was fixed in 10% neutral-buffered formalin solution for 24 hours and stored in 70% alcohol at 4˚C; the second piece was frozen in O.C.T. (Tissue-Tek O.C.T. Compound®, Sakura Finetek, Torrance, Calif).
Before harvest, blood was draw by heart puncture through a 21-gauge needle and a drop of blood was applied onto a glucometer (CVS, Woonsocket, RI) for blood sugar determination.
Wound Closure Analysis
Three independent observers who were blinded to the genotype, measured the initial wound size (I) on day 0, wound contraction (C), re-epithelialization (E), and the open wound (O) using planimetric methods (Image J, National Institutes of Health, Bethesda, Md). Wound kinetics were quantified by measuring contraction (C), re-epithelialization (E), and the open wound (O) as a percentage of the initial wound area (I). The sum of contracted, re-epithelialized, and open wound areas were equal to 100% of the original wound size (Figure 1).66
Central wound cross-sections were embedded in paraffin, sectioned, and stained according to routine hematoxylin and eosin (H&E) protocols (Figure 2). Panoramic cross-sectional digital images of each wound were prepared using Adobe® Photoshop® CS software (Adobe Systems Inc, San Jose, Calif) to analyze granulation tissue area and thickness (Figure 2B). Two independent observers, blinded to the genotype, used digital planimetry (Image J, NIH, Bethesda, MD) to quantify the area and thickness of granulation tissue in the middle part of each section at 10-x magnification. Capillary density was evaluated using 3 fields per slide viewed at 40-x magnification. Mean values of the middle and 2 lateral areas of the granulation tissue were evaluated as average capillary density. The images were viewed with Adobe Photoshop CS software. Blood vessels in each high-powered field were marked and counted.
The epithelial gap (EG) and dermal gap (DG) were measured using a Nikon shadowgraph (Nikon Inc, Melville, NY). Epithelial gap was defined as the distance between the advancing edges of clear, multiple layer neoepidermis. An EG of zero represented a completely re-epithelialized wound.67 The dermal gap was defined as the distance between uninjured dermis on both sides of the wound. Two serial sections were averaged to determine EG and DG (Figure 2B).
Immunohistochemistry. Paraffin-embedded sections were rehydrated and antigen retrieval for Ki-67 (LabVision, Freemont, Calif) was accomplished by microwaving the sections in 10 mM sodium citrate (pH 6.0) for 10 minutes. Frozen sections were fixed with acetone and stained for platelet endothelial cell adhesion molecule 1 (PECAM-1, Pharmingen, San Jose, Calif, [Figure 3]). PECAM-1 primary antibody was incubated at 4˚C overnight, while the Ki-67 primary antibody was incubated for 1 hour at room temperature. PECAM-1 signal was intensified using the tyramide amplification system (Perkin Elmer, Boston, Mass).
Vessel density quantification. Digital color images of the wound sections were preprocessed before quantification to ensure uniform contrast of PECAM-1 positive areas relative to the background. A mask of positive staining was created using the color mask function of the program Corel Photo Paint v.10 by sampling 5 different chromogen color tones represented in positively stained areas. The masked vessel areas were converted to pure black while the background was made pure white. The black and white representations were used for area quantification in IP Lab software by applying the segmentation function. Tissue regions were defined by projecting the original H&E image over the processed image. Blood vessel density, quantified over the entire image, is expressed as the ratio of vessel area to total granulation tissue area (Figure 3). Between 4 and 7 microscopic fields (40 x) were used to evaluate vessel density for each wound.
Quantification of cell proliferation. Wounds were analyzed for cell proliferation using image analysis of Ki-67 stained sections in a manner similar to the method of vessel density quantification. High-power digital images of Ki-67 stained wound sections were used to measure the number of Ki-67 positive cells relative to the total number of nuclei (Figure 3). The degree of proliferation was quantified over the entire wound section using 4–6 fields at 20-x magnification and expressed as a ratio of proliferating nuclei (Ki-67 positive) to total nuclei.
Statistical analysis. Values are expressed as mean ± standard deviation (SD) in the text and figures. Unpaired student's t-tests were used to determine the significance of differences between genotypes.
Genotyping. Tails were collected in dry ice and the polymerase chain reaction (PCR) product was amplified before RsaI digest. The positive control was obtained from Jackson Labs (Bar Harbor, Me).
Wild type versus diabetic wound healing kinetics. Delayed wound closure in db/db mice with a 1.5-cm2 full-thickness wound on the dorsum was observed after 4–6 weeks, compared to their nondiabetic counterparts, who healed in 10–16 days.65 After 2–3 weeks, db/db mice showed almost no signs of healing with wound contraction of 10%–20%, while wild type animals at the same time point were almost healed. Similarly, in another study using db/db mice,32 4-mm to 6.0-mm db/db wounds on the dorsum of each animal healed in 27.75 days ± 1.49.32,49
In previous studies that corroborate these results, different sizes of full-thickness wounds in the db/db showed significant delay compared to their wild-type counterparts.26
However, in the authors' experience, using a 1.5 cm2 excisional wound in db/db mice showed slightly faster wound closure, reaching 34% after only 9 days. On the same day, wild type animals showed 84% wound closure (Figure 4).26,65
Wound closure kinetics of the db/db mouse. Considering the 2 main mechanisms of wound healing—contraction and re-epithelialization—db/db mice were found to heal mainly by re-epithelialization (Figure 5, Table 1) during the first 10 days of the follow-up, and contraction in the last 2 weeks. Although it has been reported that contraction is the main wound healing deficiency of this animal model,65,68 the authors of the present study found that it plays a main role to facilitate complete wound closure that starts at the second week of the follow-up period. On day 10, wounds displayed a peak in new epithelial formation from the wound edges.30,31,69
One cm2 full-thickness wounds on the back of the diabetic mice reached 50% wound closure in 13.7 ± 2.9 days.30,31 Diabetic mice with 0.6-, 1.0-, and 1.5-cm2 full-thickness wounds, regardless of initial wound size, demonstrated similar delays in wound healing.26 Ninety percent closure was reached in 19.9 ± 8.6 days post wounding by 1.0 cm2 wounds in the diabetic mice and consistently reached 80% wound closure by day 21 (Figure 5).30,31
Histological Analysis
Wound tissues for histological assessment were collected in the period when 50% closure was reached (8–13 days post operation).26
The level of contraction of a wound can be measured by the dermal gap. The dermal gap of 1.0 cm2 reduced in size of 8.3 mm ± 1 mm on day 9. Microscopic quantification of the epithelial gap (the open portion of the wound) on the same day resulted in 5.8 mm ± 2 mm (Figure 2A, 2B).30,31
Microscopic analysis of wounds mid-healing demonstrated less inflammatory infiltrates in diabetic wounds than wild-type wounds.26 The granulation tissue formed by the db/db mouse in the middle of the lesion of a 1.0 cm2 full-thickness wound was 78% less when compared to wild type animals. Similar results were seen when granulation tissue thickness was measured—79% reduction (Figure 2A, 2C).26,30,31 The number of blood vessels on the same day was 5.7 ± 5.8 per high power field at
40-x magnification.
Blood vessel density in the granulation tissue reached 4 ± 3% and cell proliferation was found up to 20 ± 7% on day 9, as assessed by immunohistochemistry.
Diabetic mice and hyperglycemia. Db/db mice showed a diabetic-hyperglycemic phenotype with significantly greater blood sugar levels (590 mg/dL ± 6 mg/dL) compared to their corresponding wild-type counterparts (285 mg/dL ± 7 mg/dL).26
Genotype analysis. Genotype analysis revealed a band at 135 bp in wild type mice (Figure 6A). Mice heterozygous (db/+) for the point mutation, showed a 135 bp and 108 bp bands (Figure 6B). Mice homozygous for leptin receptor mutation (db/db) showed only the 108 bp band (Figure 6C).
Considering the increased prevalence of diabetes type 2 in the general population, the development of a reliable animal model, and the standardization of measurement techniques and study designs, are crucial aspects to facilitate improvements in therapies that seek to provide an efficient clinical translation. Among all animal models used, the db/db mouse model is the one that is most commonly used in wound care.
Different mechanisms contribute to wound closure kinetics, such as wound contraction and re-epithelialization. In the db/db mouse, the possibility to capture the different wound closure mechanisms makes it possible to quantify early effects of treatments, whereas vigorous wound contraction in wild type mice easily plaster effects. In the authors' experience with the db/db mouse it is crucial to study the relative contribution to healing from re-epithelialization and contraction in order to better understand the effects of a therapy. For example, while for some wounds, such as a chronic foot ulcer, the most important goal is to achieve faster wound closure regardless from its mechanism, others would benefit mainly from inhibition of contraction (eg, joint wounds, wounds in cosmetic relevant positions, or burn wounds covering a larger surface).
In the authors' experience with the db/db mouse model, 80% closure was consistently achieved by day 21.30 This differs significantly from the original observations of Greenhalgh et al65 who reported only a 40% wound closure on the same day. In this study, a glass slide was traced onto the wound edges to evaluate wound closure—planimetric analysis was used to determine wound area. This method might change closure data compared to the authors' method, taking a picture from a standard height using a tripod without touching the wound. Likewise, in a study performed by Sullivan et al32 using db/db mice, multiple 6-mm wounds on the dorsum of each animal healed in 27.75 days ± 1.49. In this study, digital pictures were taken of the wound area with a metric ruler in the frame. The raw, open area of the wound was measured in millimeters squared. These photographs, however, were taken with the dressing over the wound, thus, reducing the accuracy of the wound measurements due to photographic glare and blurred edges. Deformation of the wound shape through the dressing also influenced the measurements.32 When animals lost the dressing, faster wound closure was seen compared to wounds that continued with the dressing, suggesting that the dressing was not consistently maintained over the wound for the entire follow-up.32
The frequency of dressing change noted in different studies might influence wound healing kinetics mainly due to infection rate and wound fluid preservation. Although direct comparison between different studies is difficult due to discrepancies in methodology, the authors believe that differences in wound closure time using the same animal model are significant. It may be possible that differences in wound dressing and rate of infection play an important role. It has been reported that the dressing itself acts as a splint on the wound and that the accuracy in maintaining the dressing through the follow up is crucial to prevent wound contamination. The meticulous application and maintenance of the dressing, as well as stringent infection control, are important aspects in model standardization.26,30–32 Differently defined exclusion criteria with regard to dressing maintenance might explain the variability among wound closure data in the db/db mouse model.
Other details, such as the quality of digital wound photos and reliability of software to analyze the results, can enhance a study's sensitivity.
To achieve reliable data in wound closure kinetics, macroscopic and histologic analysis has to be well defined and easily repeatable. The re-epithelialized area in macroscopic pictures of the wound is widely measured but the correlation between macroscopically and microscopically re-epithelialization is not always well verified.30,31,49,65,70 In the authors' studies, macroscopically revealed wound closure showed a similar trend when compared to the epithelial gap measured in histological specimens among treated and nontreated wounds.31 Other studies comparing these two parameters found differences between wounds that maintained the dressing and wounds that did not maintain the dressing.32 More detailed and reliable analysis in clinically-relevant read outs is needed to ensure treatment effects.
Discrepancies in the results can be partially explained also with the variability in healing ability of the db/db strain. It is clear from the authors' experience that although these animals consistently develop a diabetic phenotype between 8 to 12 weeks of age, they express different levels of wound healing impairment as they progress in the pathology course. To narrow these differences, it may be important to consistently use animals of the same age (ie, 10 weeks), and strictly monitor their glucose concentration and weight. A number of animals per group (15–30), as well as the consistent use of control and case animals from the same order, may reduce the genetic variability. It has been suggested that the use of multiple wounds on one animal may correct for these changes,32 although they cannot be used if a systemic effect is hypothesized. In the authors' experience, all the animals used for the studies should be phenotyped, as some heterozygous have been found among batches of db/db directly ordered from a company (data not shown).
Currently, a variety of clinicians evaluate wounds in humans and their evaluation is a subjective, macroscopic assessment of wound healing. Better knowledge of the early events in wound healing, such as vasculature changes and cell proliferation, might provide clinicians with substantial information regarding the stages of wound healing. In the genetically diabetic mouse model, the maximal effect of a treatment can be seen at approximately day 10 when wounds reach nearly 50% wound closure. Quantification of vasculature and proliferation at about 50% wound closure can be used as predictive parameters for eventual wound outcome. The introduction of a staging system in wound healing would help physicians assess the most appropriate therapy and the efficacy of the treatment during the follow-up period.
The excisional db/db mouse model is suitable for wound healing research, especially so considering the urgent need for more effective diabetic ulcer treatments. Consistency in methodologies and definitions are needed to generate more comparable and reproducible results.


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Title: Trilogy 106: Nice and Naughty, Book 2
Author: Cat Johnson
Published in 2006 by Linden Bay Romance
Genre: Historical
ISBN: 978-1-60202-008-5 ebook
ISBN: 978-1-60202-009-2 paperback
Related books: Trilogy 102: Opposites Attract, Book 1
Other books: Trilogy 103: Red Hot And Blue, Book 1, Trilogy 105: Smalltown U.S.A., Trilogy 107: True Blue, Book 2
A fundraiser for a children's hospital brings together three fine-looking men and women who find romance that ends in some vigorous love play. Ms. Johnson pens three sizzling tales only to combine them into one seductive anthology; definitely my kind of book!
There's something sexy about a man who can cook and Scott O'Malley, in Secret Recipe, proves it. Two years of living together, Scott's girlfriend gives him an ultimatum; a wedding or it's over. Following that humiliation Scott poses nude for a "Hunky Firemen" calendar; a fundraiser for a children's hospital. Scott's Mr. July, wearing only an apron that says, "Kiss the Cook". After picking up his things from his ex-girlfriend's house, he meets his firemen buddies for a beer. Alexis heads one the hottest cooking shows and is the author of a bestselling cookbook. However, she burns water when in the kitchen. Her agent suggests that she learns to cook and finds a chef to teach her. Days of working with her chef had Alexis waking to nightmares of "falling soufflés and curdled eggs". Wanting to practice a chocolate soufflé she goes to the mini mart where she races to the dairy aisle. Running into "Mr. Muscles" she watches as he places the last four cartons of eggs into his cart. She needs those eggs…but what she gets from Scott, later, is so much more fun then whipping up a soufflé. While teaching Alexis how to cook, so she can cater the fundraiser's evening event, Scott's desire intensifies, so much, that he can't think of nothing else but Alexis. He understands now what his buddies meant when saying that the right woman will give him no doubts about getting married. He just didn't think it would happen so fast.
In Mr. December, Santa Claus calls in sick. So what's a COO to do but get into costume and play with the kiddies. Yet, one particular kiddy has sensuous curves and soft kissable lips. Jason Bryant loves Christmas not because it's the time of year that Bryant's Department store has booming sales, but the merriment of the season excites him. This is his first holiday season in managing the store on his own, and Jason wants it to be memorable. Still, having a woman drop into his lap is not what he had in mind, though his racing heart and his happy northern regions tell him that it wasn't all bad. Tessa O'Donnell plops into Santa's lap and quickly realizes her error – this is not her brother, Troy. Embarrassed, Tessa introduces herself while exclaiming how delighted though surprised she is that "stuffy old Bryant" agreed to hold the fundraiser's Bachelor Auction. Never realizing that the "old Bryant" she just maligned is standing in front of her. Tessa finds out how stuffy Bryant is when locked in his office with a large serviceable desk available.
What do a fireman and a chef have in common? Fiery passion. In Can't Buy Me Love the pages are scorched with it. Zoey Massey is sole owner of a catering business and can bake a cake that resembles a little poodle. Except she cannot keep up with the demands of clients and the bookkeeping too; the vendors are demanding payment, now. Mulling over her past due bills, Zoey smells something burning. Rising out of her chair in a panic, bangs her head on the rod overhead; her office is in the closet. She comes to with a hunky man standing over her. Gordy Mullen, a divorcee, is fed up with fickle women. More so when reading in the newspaper that his ex-wife is marrying another firefighter; the very reason why she divorced him. Walking home, he passes Zoey's Events and sees a plume of smoke swirling from within. Entering the building Gordy finds Zoey on the floor, and when coming around she tells of bumping her head and blacking out. He's worried she may have a concussion so stays the night at her place. A few days later Gordy comes across Zoey on the floor again, this time in a panic attack. He finds his concern for her alarming, since he swearing off woman after his divorce. She does make his blood boil with a need that has been dormant for quite a long time. As Zoey leaves for her aunt's funeral Gordy hopes she'll call wanting him to make love to her.
An altogether humorous anthology, Trilogy 106: Nice and Naughty entertains with witty dialog and diverse plots that are gratifying and engaging. Ms. Johnson's Secret Recipe is a sizzling story with a plausible plot about a culinary diva trying to learn to cook without jeopardizing her career. Mr. December is another amusing tale about a rich business man who meets and falls in love with a working-class girl. Can't Buy Me Love is a delicious, sexy romp as a divorced fireman and an entrepreneurial woman find love again. The characters are witty and charming as they heat up the pages with sexual tension and sultry unions. Alexis, Tessa and Zoey are quick-witted and independent; owenrs of their professional and personal destinies. Whereas Scott, Jason, and Gordy are he-men but who know how to treat a woman; with compassionate words and lots of kisses.
Trilogy 106: Nice and Naughty is the sequel to "Trilogy 102: Opposites Attract, Book 1", and are both published by Linden Bay Romance. Ms. Johnson's other books look quite appealing too: Trilogy 105: Smalltown U.S.A., Trilogy 103: Red Hot And Blue, Book 1 and its sequel Trilogy 107: True Blue, Book 2.
A dedicated reader,
Pamela Jenewein
Cat Johnson's website Buy Trilogy 106: nice and Naughty
Buy Cat Johnson's Linden Bay Books


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Welcome to the homepage of the newly created
Scottish Fire Heritage Group.
This 'new' group consists of
those passionate in preserving Scotland's firefighting
past. We are a group of friends linked by a common theme and
all involved have been instrumental in promoting the history
of firefighting in Scotland both with the preservation and
operation of historic vehicles and the acquisition of fire
related equipment and documents.
The website has been totally reconstructed
and we hope you find it both interesting and educational.
It is our intention to focus on the firefighting histories
of Aberdeen and north east Scotland, Glasgow and Edinburgh,
the oldest municipal fire brigade in the world. You will also
find online a photographic collection of the preserved appliances
and equipment each of the three branches of the SFHG has in
its care.
On the website you will find a most comprehensive
links page and details of other collections and fire brigade
museums. The Scottish Fire Heritage Group is also a member
of the Fire Heritage Network UK and is represented on the
Executive Committee by Bob Wright, one of the founder members
of the Network. Our involvement with FHNUK has enabled our
group to forge links with other like minded organisations
throughout the United Kingdom and beyond. For many years now
we have had a long association with the firefighters of Schonstadt
in Germany with many friendships forged through this involvement.
We have also included a Blog
on our website. This is a facility that enables the viewer
to leave comments and have some fun also. It can also be used
to promulgate information regarding meetings etc. Hopefully
our team will be able to answer any relevant questions left
on the Blog.
Home About
Us Services
Goddess Related
Links Central
Fire station Saint
Mungo Contact
BLOG For
more info contact Bob
Igniting the Memories


text:
This gorgeous site is dedicated to the artwork, graphics and logos of record center labels. I love the minimal layout and the way the record collection is thrust immediately into the limelight! The header typeface is excellent and superbly striking while the overall design lends itself perfectly to enjoyable browsing!Posted in Web Design → Music
Some great interface design here from the people at Ask.com. It follows the template that Google has used for Google Mobile and looks great! I particularly like the intuitive use of tabs and voice search!Posted in Interface → iPhone App
A stylish but simple business card design for a graphic designer. The use of black and white works very effectively to convey the vital information quickly! I particularly like the use of a focal strip across the centre, it\'s a nice design touch!Posted in Branding → Business Cards
An interesting site for a design studio based in Strasbourg that uses some great illustration to draw you in! The spacing is good as is the overall layout. I like the clean design and simple use of colour, it doesn\'t bombard your senses!Posted in Web Design → Design
Flixster is an excellent App for finding movie showtimes and looks simply great! The use of movie posters and imagery throughout is really effective, as is the incorporation of scores from Rotten Tomatoes.Posted in Interface → iPhone App
A clean and bright site for a web design agency. The colour palette is unthreatening and invites you in to investigate further. I really like the venn diagram and attention to detail throughout!Posted in Web Design → Design
Foursquare is an App that makes great use of the iPhone\'s location services! I love the use of tabs and intuitive interface. The icon and badge design is what makes Foursquare so appealing, you just have to get that next badge!Posted in Interface → iPhone App
Striking is the word the immediately springs to mind when you land on the site of Split Creative! I particularly love the logo and brilliant use of colour. The gallery section is gorgeous and serves as an extremely effective focal point!Posted in Web Design → Design
A great iPad App for finding the perfect place to eat out! I love the use of maps and classy blue pins! The selection wheels are delightfully satisfying to use!Posted in Interface → iPad App
An interesting site for a Beekeeping auction. I like the use of photography and fascinating typeface used! The layout of the site is intuitive and allows you to immediately get the information that you want!Posted in Web Design → Misc
As you\'d expect from the people at Google their translation App is clean and instantly useable. I really like the simple three tab approach and bright clear menus! The use of icons and buttons is great, my particularly favourite is the red and black \'Speak now\' icon.Posted in Interface → iPhone App
A superbly stylish and classy design for a hotel and spa. I love the unfussy nature of this design and the clean typeface used! That it works excellently in white on a black background is merely a bonus!Posted in Branding → Logo
A clean and intuitive App that allows you to order groceries on the go! I love the use of images, it truly allows you to have your shopping in your pocket. I also particularly like icon and tab design, the Ocado logo itself is especially nice!Posted in Interface → iPhone App
A clean and unfussy business card design that makes a straightforward statement about the philosophy of the designer! I like the bright wooden background on which it\'s displayed and the subtle colour palette used!Posted in Branding → Business Cards
A brutally simple site for a DJ that uses a single photograph as its only focal point. The photograph is striking and works hard to draw you in! I like the minimal amount of text and the simple icon design.Posted in Web Design → Music
An excellent iPhone App for banking on the go from a bank that knows the importance of good design! The bold use of black and white makes a statement about security and confidence while the intuitive use of tabs makes for a great user experience!Posted in Interface → iPhone App
A great logo that\'s based on an excruciatingly simple idea! The use of lowercase if really effective, as is the clean fading background. I love the colour palette and its beautiful implementation!Posted in Branding → Logo
A slightly clumsy yet intriguing site for a social experiment. The use of illustrations throughout is good and works well to keep a visitor reading! The simple colours are great but the layout isn\'t very clear and could benefit from some more tweaking!Posted in Web Design → Misc
The perfect App for keeping track of how your favourite F1 driver is doing! The sheer volume of information available here is astounding, it\'s amazing how uncluttered the App feels! I like the race map and intuitive tab layout.Posted in Interface → iPhone App
A wonderfully simple yet memorable logo design for a web development company. I love how the @ symbol has been used in the design and the green colour palette! I particularly admire the font chosen for the text, it\'s clear but retains character!Posted in Branding → Logo


text:
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News and Events
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Undergraduate Programs
General News
General News
Second Class of Rogers Scholars Studies at LWC
A total of 32 rising high school juniors from 27 Eastern and Southeastern Kentucky counties spent July 7-12 at LWC as Rogers Scholars.
Posted: 07/16/2013 - 08:55:08 AM
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Posted: 07/07/2013 - 11:21:54 AM
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Bonner Scholars Program Gives $2,000 to Adair County Schools
The Bonner Scholars Program awarded $2,000 in grants to Adair County schools. The grants will be used to enhance after-school programs at Adair County Elementary School and Adair County Primary Center.
Posted: 07/02/2013 - 03:06:52 PM
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First Class of Rogers Scholars Studies at LWC
A total of 32 rising high school juniors from 22 Eastern and Southeastern Kentucky counties spent June 24-28 at LWC as Rogers Scholars.
Posted: 06/29/2013 - 12:08:06 PM
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Endowed Scholarship Honors Memory of LWC Freshman
The Caleb Capps Baseball Memorial Scholarship will be presented annually to an LWC baseball player from Adair, Barren, Cumberland, Green, Hart, Metcalf, Monroe or Russell counties.
Posted: 06/29/2013 - 12:03:47 PM
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Coleman Named VP of Administration and Finance
Mark Coleman has been named vice president of administration and finance.
Posted: 06/19/2013 - 09:22:31 AM
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LWC Staff, Students Donate Sports Equipment to Local Military Serving in Jordan
LWC students and staff donated sports equipment to area residents serving in the military in Jordan.
Posted: 05/30/2013 - 07:59:22 PM
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Authenticity Key to LWC's Success, Luckey Tells Founders' Day Guests
Passion for LWC is fueled by the college's genuine character, President Luckey told LWC supporters.
Posted: 04/26/2013 - 12:39:44 AM
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Founders' Day, Concert Conclude Academic Celebration Week
A spring concert and the annual Founders' Day Dinner will wrap up Academic Celebration Week.
Posted: 04/24/2013 - 02:52:51 PM
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Bio-Based G-OIL Helps LWC Become a Greener Campus
LWC's vehicles switched to bio-based G-OIL, which has made the college greener.
Posted: 04/09/2013 - 08:30:52 AM
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Columbia-Adair County Generosity Honored by Operation Christmas Child
Columbia-Adair County recevied the inaugural Bruce Kramp Faithful Servants Award from the Danville Area of Operation Christmas Child.
Posted: 03/05/2013 - 11:54:26 AM
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Drake Named President of Central Methdodist University
Vice President for Administration & Finance Roger Drake will be the 26th president of Central Methodist (Mo.) University. He will assume the office July 1.
Posted: 02/01/2013 - 01:57:39 PM
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2012 Highlights Include Record Enrollment, Faculty and Winter Commencement
A look at the 2012 highlights at LWC.
Posted: 12/29/2012 - 02:06:10 PM
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Veterans and Their 'Amazing Stories' Honored at Annual Luncheon
A total of 188 guests attended LWC's 10th-annual Veterans Appreciation Luncheon.
Posted: 11/12/2012 - 09:49:58 PM
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Veterans Appreciation Luncheon Nov. 12
The LWC Veterans Appreciation Luncheon will be held at 11 a.m. CT on Monday, Nov. 12. The luncheon is free to all veterans, veterans' survivors and a guest. Guests should RSVP by contacting Lindsey Wilson at firstname.lastname@example.com or (270) 384-8400.
Posted: 11/05/2012 - 03:45:46 PM
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Enrollment Increases 2.9%, Sets New Record at 2,677
LWC's enrollment for 2012-13 is a record 2,677 students.
Posted: 10/31/2012 - 06:54:03 PM
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Board of Trustees Adds 3 New Members, Welcomes New Student Services Chair
The LWC Board of Trustees named three new members and a new Student Services chair.
Posted: 10/25/2012 - 11:50:26 PM
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LWC Community Prepares for Opening of 'Huge' School Year
The 2012-13 school year officially opens Aug. 22.
Posted: 08/15/2012 - 11:06:57 AM
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Blue Raider Aquatic Club Home of Region's Budding Swimmers
The Blue Raider Aquatic Club provides an outlet for children from ages 6-18 in Southcentral Kentucky.
Posted: 07/17/2012 - 02:41:05 PM
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First & Famers Gift Supports Adair County Residents Who Attend LWC
First & Farmers Bank donated $10,000 to the Lindsey Wilson Fund to help Adair County residents attend the college.
Posted: 07/17/2012 - 01:31:05 PM
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2008 Lindsey Wilson College
210 Lindsey Wilson St. Columbia, Ky 42728
Local: (270) 384-2126
Fax: (270) 384-8200
Toll Free: (800) 264-0138


text: Raphael Kirchner | IBDB: The official source for Broadway Information IBDB: The official source for Broadway Information Official Broadway League sites: - sites - broadway.org broadwayleague.com broadwayfanclub.com kidsnightonbroadway.com stagespecs.org tonyawards.com Quick Search For: In This Category: All Show People/Org. Theatre Season Raphael Kirchner Designer, Writer Male Productions ProductionsDate of ProductionsDance and Grow Thin[Musical, Revue, Original] Book by Raphael Kirchner Costume Design by Raphael Kirchner Jan 18, 1917 - Jun 02, 1917The Century Girl[Musical, Revue, Original] Costume Design by Raphael Kirchner Nov 06, 1916 - Apr 28, 1917 Find out where Raphael Kirchner and are credited together © 2001-2015, The Broadway League, All Rights Reserved. (Copyright and Disclaimer)


text:
France - all things to all people
What is it that makes France the most popular tourist destination in the world? Is it the beautiful landscapes, the lovely beaches, the gourmet food, the charming cities, the luminous lakes or the magnificent mountains? The most likely answer is that it is a combination of all these things - making France all things to all people. France's main cities - Paris, Lyon, Bordeaux, Marseille, and Reims - all have their own distinct flavour. Paris is elegant, Marseille cosmopolitan, Lyon and Bordeaux gastronomic, and Reims the home of champagne. The country's landscape changes from one region to the next. From the flat north where the symmetrical white headstones of the war graves are visible across the plains, to the hilly south where the Mediterranean sun warms the sandy beaches and bougainvillea. On the west coast the castles of the Loire Valley and the beaches of Brittany and the Vendee keep visitors returning year after year.
Why Go?
The food is fabulous, the beaches are clean, the atmosphere convivial, the cities, towns and villages delightful and the countryside beautiful. Add to this the opportunity to see some enchanting castles, imbibe fine local wines and eat divine pastries and fresh baguettes, and you've got yourself a terrific destination.
When to Go?
France's climate differs from region to region. The nicest time to visit the north of France is from spring to autumn as winters can be biting. In the south the winter is shorter and milder than in the north, and summers are hot and dry. France's popular coastal areas are extremely busy during July and August, so visits outside of this time can be more pleasant – especially in the overcrowded Cote d'Azur.
How to get there?
There are numerous direct flights to France. Important hubs with a number of routes to the UK include Brest, Dinard and Nantes serving northwest France; La Rochelle and Bordeaux serving the Atlantic Coast; Biarritz, Pau and Carcassonne serving the Pyrenees; Nice, Perpignan and Marseille on the south coast; Bergerac serving The Dordogne; Lyon serving the Alps; Poitiers serving the Loire.
Must see
In the north, visit the D-Day beaches in Normandy and the War Graves of the Somme. They are incredibly moving. In the Loire, drive along the river from Blois to Tours taking in the castles, stopping for a picnic and doing a spot of wine tasting. In Champagne, take a tour at one of the champagne houses in Epernay. In the Dordogne see the incredible 17,000 year-old cave drawings at Lasceaux. In the south visit the glorious perfume-centre of the world, Grasse, and have lunch in one of its lovely squares.


text:
Brand Columbia
Style BENBOW-C02-60-15
Series Benbow
Style Fashion
Size Eye: 60/Bridge: 15/Arm: 130
Frame Metal
Color Brown
Lens Brown gradient scratch/impact resistant
Protection 100 percent UVA and UVB
Arms Metal design logo signature on top of left arm with plastic ends
Nose Pads None
Manufactured China
Dimensions 7 inches from temple to temple
Other Logo signature in upper right corner of right lens. Polarized Lens
Material Metal
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text:
What is the thyroid gland?
The thyroid gland located in the neck produces thyroid hormones which help the body use energy, stay warm and keep the brain, heart, muscles, and other organs working normally.
Thyroid hormone is used:
- to replace the function of a failing, or failed, thyroid gland (replacement therapy), and
- to prevent further growth of thyroid tissue (suppression therapy), particularly in patients with a history of thyroid cancer
Why do I need thyroid hormone pills?
Hypothyroidism is the most common reason for needing thyroid hormone replacement (see Hypothyroidism brochure). Pure synthetic thyroxine (T4), taken once daily by mouth, successfully treats the symptoms of hypothyroidism in most patients.
How is the dose of thyroxine chosen?
The initial T4 dose is carefully selected based on your weight, age, and other medical conditions. The dose is then adjusted based on your thyroid hormone levels and your symptoms. The current branded forms of T4 are Synthroid® Levoxyl® Levothyroid®, Tirosint® and Unithroid®. Although these all contain the same synthetic T4, there are different inert ingredients in each of brand names. In general, it is best for you to stay on the same brand name.
How do I take thyroxine?
T4 is taken just once a day and results in very stable levels of thyroid hormone in the blood stream. The best time to take T4 is probably first thing in the morning on an empty stomach. However, the most important thing is to be consistent when you take it. If you miss a dose of T4, it is usually best to take the missed dose as soon as you remember.
Does thyroxine interact with any other medications?
Medications that may cause a change in your T4 dose include birth control pills, estrogen, testosterone, some anti-seizure medications, and some medications for depression. Iron, calcium, soy, and some cholesterol-lowering medications can decrease the absorption of thyroid hormone.
Should I take thyroxine while I am pregnant?
Since T4 is a hormone normally present in the body, it is absolutely safe to take it while pregnant. You often need an increased dose of T4 during pregnancy, so it is important to have thyroid hormone and TSH levels measured once you know that you are pregnant.
What about "natural" thyroid hormones?
Desiccated (dried and powdered) animal thyroid (Armour®), now mainly obtained from pigs, was the most common form of thyroid therapy before the individual active thyroid hormones were discovered. While desiccated thyroid contains both T4 and T3, the balance of T4 and T3 in animals is not the same as in humans, so the hormones in animal thyroid pills aren't necessarily "natural" for the human body. Further, the amounts of both T4 and T3 can vary in every batch of desiccated thyroid, making it harder to keep blood levels right. Finally, even dessicated thyroid pills have chemicals (binders) in them to hold the pill together, so they are not completely "natural". Desiccated animal thyroid is rarely prescribed today, and there is no evidence that desiccated thyroid has any advantage over synthetic T4.
What about T3?
While most actions of thyroid hormone are most likely due to T3, most T3 in the body comes from the conversion of T4. The conversion of T4 to T3 is normal in hypothyroid patients, so the body can regulate to levels of T4 just as if the T4 was being produced from the thyroid gland. T3 has a very short life span in the body, while the life span of T4 is much longer, ensuring a steady supply of T3. There is no indication for the use of T3 alone for the treatment of hypothyroidism.
What about combined T4 and T3 treatment?
There has been interest in whether addition of a low amount of T3 given twice or three times a day in combination with T4 may benefit those patients that do not feel completely normal on T4 alone. A trial period of 3 – 6 months is reasonable to determine if combination T4 and T3 therapy will help.
Will thyroid hormone help me if I have hypothyroid symptoms but normal thyroid hormone levels?
In several scientific studies, there was no difference between T4 and a placebo (sugar pill) in improving symptoms, depression or well-being in patients with "hypothyroid" symptoms and normal thyroid hormone levels.
Why would I need to go on thyroid hormone suppression therapy?
Thyroxine can also be used to keep the TSH level in the low, or low normal, range. In the past, such thyroid hormone suppression therapy was used to prevent benign thyroid nodules and enlarged thyroid glands from growing. More recent evidence has shown that this practice is not effective in regions of the world that have adequate iodine intake (such as the USA). Moreover, excess thyroid hormone can increase the risk or heart rhythm problems and bone loss making the use of thyroxine for suppressing benign thyroid tissue more risky than beneficial in iodine sufficient populations.
Thyroid hormone suppression therapy is also an important part of the treatment of thyroid cancer and is effective in stopping the growth of microscopic thyroid cancer cells or residual thyroid cancer. In this case, the benefit of suppression therapy outweighs the risks.
Further Reading
Further details on this and other thyroid-related topics are available in the patient information section on the American Thyroid Association® website at www.thyroid.org.
Thyroid Hormone Treatment FAQ for Saving and Printing (PDF File, 130 KB)
Thyroid Hormone Treatment FAQ for Saving and Printing (PDF File, 75 KB)