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It's not just illnesses you need to protect yourself from in winter.
Winter weather can bring many risks to you and your family. There's the usual winter coughs, colds and flu, but then there's also risks to your health associated with flooding and storms.
If you are normally healthy, many of the coughs, colds and minor illnesses that seem to happen more frequently during winter can be safely managed yourself. There's plenty of advice on the NHS Choices website and you can also talk to your local pharmacist.
Flu affects people in different ways. If you are usually healthy you will usually shake it off within a week. However, you are advised to get your flu jab if you:
Contact your GP or pharmacist if you think you, or someone you care for, might qualify for a free flu jab (see The flu vaccination winter 2014 to 2015: who should have it and why).
If you are the parent of a child who is over six months old and has a long-term condition listed above, you should also speak to your GP about your child having the flu vaccine. Your child's condition may get worse if they catch flu.
This year, the NHS is offering a flu vaccination to all two and three-year old children through GP surgeries. Children of this age will be invited by their GP to come in for a free flu vaccination.
An influenza pandemic, often called 'Pan Flu', happens when a new influenza virus emerges and spreads round the world. ('Pandemic' is the name given to the worldwide spread of a new disease).
Because the particular strain of influenza is new, most people will not have immunity to it, which means that very large numbers of people are likely to become infected across many countries in a relatively short space of time. Sometimes millions of people may become ill in just a few weeks. A Pan Flu outbreak will also cause more serious symptoms than seasonal flu (the kind of flu that affects many people every winter) in anyone who catches it.
It is by no means an annual event but there have been a number of pan flu outbreaks in the last 100 years, so it's right that the country remains prepared. pan flu outbreaks are usually given their own nickname. These include Spanish flu, which killed millions of people across the world in 1918, and swine flu, which turned out to be a relatively mild pandemic in 2009, but still caused serious illness and death in a small number of cases.
If there is an outbreak of pandemic flu, you will probably hear about it first through news reports in the national and local media. You may also hear about it through social media networks. It is likely that an outbreak will start outside the UK so you will probably hear about people becoming ill in other countries first before it spreads here.
Listen out for further updates and advice, which will be given out on national and local news reports on TV, radio and news websites. These updates will tell you what symptoms you should look out for in you and your family and what to do if you think you, or anyone you live with or look after, has become ill with the virus. Keep listening to news updates until the pandemic is declared over, because the advice may change quite quickly as doctors gather more information about the effects of the particular virus causing the pandemic.
The below tips are provided by the Environment Agency and Public Health England. You can also read more advice about how to protect your home from flooding.
Pack a "flood kit" in case you need to leave your home. This should include:
Be careful when moving family, pets or important belongings upstairs or to higher ground.
Further information from Public Health England on health and flooding..
Read more practical advice for protecing and cleaning up your home
The direct dangers to human health from windstorms are individual accidents (being blown over, or struck by flying or falling debris/masonry), road traffic accidents (overturning vehicles, collisions with fallen trees). Injuries can also be sustained preparing for and clearing up after windstorms.
The Met Office is not responsible for the content of external Internet sites
Advice on keeping warm this winter
Keeping your home warm efficiently
Prepare and protect against Carbon Monoxide poisoning
Winter is a great time to get out and about and enjoy our countryside.
What did the UK coastline sound like during the summer of 2015? What are the distinctive sounds of Scottish estuaries, Cornish beaches, the Pembrokeshire coast or a busy seafront? In what ways do these sounds fascinate us, move us or seem important to us?Read more
Practical tips to protect your home from the cold this winter.
Help your neighbours in cold weather in a few simple ways


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|Tourists top Crawdads, 5-0
|Written by Staff Reports
|Saturday, 06 August 2011 22:45
The Hickory Crawdads, 1st-Half Northern Division Champions, fell to the Asheville Tourists, 5-0, before 2,233 fans at Historic McCormick Field in Asheville on Saturday evening.
After both starters --losing pitcher Nick Tepesch (6-4) for Hickory and winning pitcher Nick Schnaitmann (2-1) for Asheville -- alternated scoreless innings through the first two and a half frames, the Tourists (55-56, 24-18) got on the board with a two-out rally in the bottom of the third. Cristhian Adames singled and stole second before Rafael Ortega knocked him in with an RBI single. Ortega swiped second, and then cruised home on an RBI double by Brett Tanos for a 2-0 lead.
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text:
June 27, 2013: Trey Burke, left, with NBA commissioner David Stern. / Jerry Lai/USA TODAY Sports
- Filed Under
The NBA draft gets under way at 7:30, but we started chatting at 7 because there's plenty to discuss. Who will the Pistons go after at No. 8 overall? Where will Michigan's Trey Burke fall to? Join our live blog and chat with us as the festivities kick off in Brooklyn!
Free Press special writer Anthony Odoardi will lead the chat during the NBA draft tonight.


text:
politically motivated
By Diogenes (bio - articles ) | Dec 05, 2008
Dr. Robert Blum has placed his rubber-stamp of approval on a new oh-so-very-scientific study concluding that women who procure abortions do not have significant psychological after-effects. The study was done by scholars at Johns Hopkins University, in a program that is subsidized by Planned Parenthood of Maryland. Dr. Blum himself is the former chairman of the board of the Guttmacher Institute, a Planned Parenthood spin-off; he has served as an expert witness for abortionists challenging parental-consent laws.
What do you suppose would happen if another scientific study reached the opposite conclusion, and it emerged that the research was sponsored by the National Right to Life Committee and headed by the chairman of a crisis-pregnancy center? For one thing, that study wouldn't have been included in the Johns Hopkins research. The Family Research Council notes:
Not surprisingly, the Hopkins study is severely tainted by the team's pro-abortion bias. As our experts have been quick to point out, Blum's review of 21 surveys conveniently omitted the stacks of research published in peer-reviewed journals that showed an association between abortion and negative mental health effects.
Dr. Blum explains that studies finding psychological damage from abortion are "politically motivated." And he isn't?
An appeal from our founder, Dr. Jeffrey Mirus:
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Non-Immigrant Visas
- Translation:
- Română
Non Immigrant Visa Information
Last update: October 5, 2015
Important Notice – Passport Validity
Please note that applying for a visa with a limited validity or temporary passport may cause your visa to be limited as well. If you have applied for a visa with a limited validity or temporary passport on more than one occasion, you may be asked to obtain a full validity passport prior to visa issuance. To avoid delays in visa processing, please apply with a full validity passport. Full validity Romanian passports are valid for five years. If your passport is valid for one year or less, it is a limited validity passport.
Passport Home Delivery Service
Please click here for more information about this service.
For Visa Appointments and Visa Information call 03 17 800 260 or visit www.ustraveldocs.com/ro
New Appointment System and Application Procedures for Visa Applicants Available at www.ustraveldocs.com/ro
All applicants (except those who qualify for the Visa Renewal program) must appear at the Consular Section for a personal interview. We encourage applicants to carefully read the information on this website before coming to their interview.
All Romanians who want to visit the United States temporarily must apply for a non-immigrant visa. There are a wide variety of reasons for a non-immigrant visa, including tourism, business, medical treatment, and certain types of temporary work. The type of visa needed is defined by immigration law, and relates to the principal purpose of your travel. For an overview of the types of nonimmigrant visas available under immigration law, please see non-immigrant visa classifications on the USCIS website.
Holding a visa does not guarantee entrance into the United States. Although you were issued a visa, only the U.S. Customs and Border Protection (CBP) has the authority to allow you into the United States and to determine the length of your visit. At the port of entry, a CBP official must validate your Record of Arrival - Departure (Form I-94) which tells you how long you may stay.
The information on this website is designed to help you understand the process and to come to the interview prepared. The visa application process is explained in detail at Application Process link. If you have any visa related question, please check our Frequently Asked Questions section. Every applicant must fill out an application form online. For a list of the standard forms required, visit the Forms and Documents page. Depending on the type of visa, applicants may be required to bring additional documents to the visa interview. For a list of required documents, select the type of visa for which you are applying from the list to the left.
You may also find here useful information about Visa Refusals and Questions and Answers about Section 214(b) of INA (PDF File, 418kb). If you are unable to find the information you need on our website, feel free to contact us at firstname.lastname@example.com.
Visa Appointment and Processing Wait Times
There are many factors that may influence the processing of individual visa cases, such as additional administrative processing or incomplete applications. Applicants should plan well in advance of their proposed travel plans and apply early for a visa. For further information on wait time, please check the Visa Appointment and Processing Times page. In general, if the visa is approved, the next business day it will be printed and the passport will be delivered to the courier services provider (TNT).
Legal Rights and Protections
The U.S. Government is committed to fight human trafficking and labor abuses in all their forms. The William Wilberforce Trafficking Victims Protection Reauthorization Act explains your rights, protections and resources. Further information is available at page Rights and Protections for Temporary Workers.
Expedited Visa Renewal Program
Certain visa applicants meeting the requirements below may utilize the new procedure to renew their visa. The program applies to the following visa categories:
B1/B2 (Business/Tourism) Visa Applicants:
- Have a previously issued B1/B2 visa which is either still valid or has expired within the last 48 months and have been interviewed after January 1, 2008.
Visa applicants with the age of 80 or more and minors are also entitled to use this program.
F, J*, M (Students and Exchange Visitors) Visa Applicants:
- Have a previously issued F, J*, or M visa which is either valid or has expired within the last 48 months, have been interviewed after January 1, 2008, and will continue participation in the same program or attendance at the same institution as in the previous visa.
*(Does not apply to Summer Work Travel. See Below.)
C1/D (Crew Members) Visa Applicants:
- Have a previously issued C1/D visa which is either still valid or has expired within the last 48 months and have been interviewed after January 1, 2008.
I (Foreign Media Representatives) Visa Applicants:
- Have a previously issued I visa which is either still valid or has expired within the last 48 months and have been interviewed after January 1, 2008.
O-1 (Aliens with Extraordinary Ability), O-2 (Accompanies or Assists O-1 holder) and O-3 (Dependant of O-1 or O-2) Visa Applicants:
- Have a previously issued O-1/O-2/O-3 visa which is either still valid or has expired within the last 48 months and have been interviewed after January 1, 2008.
Please note that:
- Visa applicants who changed their name after marriage/divorce are not eligible for this program. They will have to come to the visa interview.
- J Summer Work Travel visa applicants are not eligible for this program. They will have to come to the visa interview.
- If your previous passport with a U.S. visa was lost/stolen, and you meet all requirements for the visa renewal program, please submit a police report stating that your passport was lost/stolen, in addition to the required documents.
Visa applicants wishing to take advantage of this service should ensure they send their application and supporting documents to the Embassy through TNT. All passports will be collected by the applicants from the TNT offices. When submitting your application and supporting documents, please allow time for the courier service and the adjudication by a Consular Officer. Please note that we reserve the right to call applicants for an in-person interview for any reason deemed necessary by the adjudicating Consular Officer.
Diplomats and Government Officials
Certain applicants may qualify to use this program, which allows them to apply for a visa without a personal interview. To see the qualifying terms and conditions and the procedure that needs to be followed, please go to Diplomats & Government Officials page.
Business Visa Facilitation Program (BVFP) for AMCHAM Members
This program is designed for business travel only for full-time employees of member companies of the American Chamber of Commerce in Romania (AMCHAM). The applicants entitled to this program will have access to special appointment blocks each week. For further information on this program, please contact the American Chamber of Commerce in Romania.
Summer Work Travel
The Summer Work Travel program allows full-time university students to work in the United States for up to four months during their summer vacation. For more information about the program, please visit our Summer Work Travel page or the Summer Work Travel page of the Department of State.
Important Message
You may also find here useful information about Visa Refusals and Questions and Answers about Section 214(b) of INA (PDF File, 418kb). If you have particular concerns, complaints or comments about customer service or a visa issue, please feel free to contact the Consul General at firstname.lastname@example.com. The Consul General reviews all such correspondence and will respond within two to three business days.
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Are you planning to work in the U.S.? Know your Rights! (PDF - 386kb)
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Please be aware of strangers who approach you around the Embassy, metro stations, or Gara de Nord railway station offering to help you with any part of your visa application process. Never pay any fees to these individuals.
If such incidents occur, please inform/report (to) the Consular Section at 021-2706000 or via e-mail at email@example.com.
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text:
Chris Carpenter
- Filed Under
Chrissy Carpenter, of Willow Haven Care Center, has been chosen Employee of the Month for February 2013 .
An employee is chosen by their peers based on their positive attitude, leadership skills, team work and work ethic.
Carpenter is a 15-year Zandex employee and is a state-tested nursing assistant. Some of her responsibilities include providing for the overall personal care and well being of a resident. She has a son and daughter and resides in Roseville.
Willow Haven Care Center is a 99-bed skilled nursing and rehab facility that has provided care for seniors since 1976. The facility is located at 1020 Taylor St. in Zanesville and is owned and operated by Zandex Health Care Corp.


text:
The Canyons At Blackjack Ridge
8 Reviews
- 1801 N McKinley Ave, Sand Springs, OK 74063
- (918) 246-2606
- www.sandspringsok.org
|18 total holes at facility
|Green fees - $23 to $32 (estimate)
|Designed by Floyd Farley
|Built in 1958
|Driving Range: Yes
|Municipal golf course
The Canyons At Blackjack Ridge is an 18-hole regulation length golf course in Sand Springs, Oklahoma. This short layout has 3 sets of teeboxes for a fun, but challenging golfing experience. Online tee times may be available at The Canyons At Blackjack Ridge or at nearby golf courses, usually offered at a discount from the normal rate.
|Course Rating
|Back Tees
|Golf Pro: Brian Talley
|Course Superintendent: Brad Temke
|Manager: Brian Talley
Although the data is normally right, occasionally there may be errors. If you locate something that needs updating, please inform us immediately.
Tee Times for Canyons At Blackjack Ridge, The (and other courses)
5 Stars (1 Reviews) - Last updated on July 15, 2014
There is a Yelp.com page for "The Canyons At Blackjack Ridge - Sand Springs, OK"
The score on Yelp is 5 out of 5. That score is an average of 1 ratings, and it is rounded to the nearest 0.5. Also note that sometimes Yelp excludes from that score any reviews that that it classifies as "not recommended."
Read reviews on Yelp.com
4.7 Stars (7 Reviews) - Last updated on July 15, 2014
On the Google+ page for "The Canyons at Blackjack Ridge", they have an average rating of 4.7/5, and they have a total of 7
Read the full reviews on Google+
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text:
A dedicated follower of fashion
A Palmerston North student has designs on winning a career in fashion.
Benny Tipene takes to Europe
Benny Tipene set off on a European tour lately and Carly Thomas caught up with him for a bit of a chat.
Dogs can leave others needing stitches
I never thought I would get older but it seems to creep up on you. Some may remember Sunday family picnics or Dad taking you fishing but these seem to be unfortunately forgotten as life is very busy and many people work on Sundays. And that includes us here at the hospital.
Yarn bombers strike again
Palmerston North's Woolly Riot have been bombing the city again...with wool.
Earthy inspirations in art
Bonanza is the Zimmerman Contemporary Art Gallery's latest exhibition from Cam Munroe.
Exhibition spins a colourful yarn
A Palmerston North exhibition puts some creative and colourful wares on show.
Memories made in music
Some old favourites are among the musical repertoire for Palmerston North's Showcase Singers' upcoming show.
Words are her way
Amy Atkins knows where she is going. She is young, ambitious and is rapidly filling up pages with words. Carly Thomas sat down with her to talk about her writing, her acting and the blank page of her future that is waiting to be filled.
Beer and music combine
Interpretive beer is a thing according to a band launching a brew and an album in Palmerston North.
Tim's stupid dessert wins MasterChef
OPINION: Paul Henry (TV3 Tuesday) called it ludicrous and "bloody stupid" and I agree.
Colour pops up on Coleman Mall
Palmerston North artist Georgia Lambert loves colour and she has added a splash of it to a vacant shop.
The path to spirituality via science
Rohana Ulluwishewa is publishing his award-winning manuscript to help people look rationally at spirituality.
REVIEW: Choir delivers social message
REVIEW: Hailing from Australia, the Newcastle People's Chorus is a twenty-eight member strong, union choir with a repertoire which places emphasis on social justice and worker's rights.
Puffing billies go for a long stroll
REVIEW: Two hilarious puffing billies take a hike in yet another walking film.
Boomergang cats, dogs and the holiday season
Pigeons are not the only ones who can find their way home over long distances.
Theatre made from the ground up
Massey University Drama Society members are doing everything for themselves, figuring it out along the way and putting something fresh on the Palmerston North stage. Carly Thomas sat down with an eclectic mix of students to find out more about their new festival.
Bleeding for her art
A Palmerston North artist is putting herself into her paintings by using her menstrual blood.
Episode succeeds in changing history
OPINION: Before the Kennedys there was another political dynasty, the Roosevelts.
'Dad joke' gets film into finals
Two Palmerston North film makers are hoping for a win at an Australasian video competition.
Everest reaches the summit of emotions
Emotional Everest disaster drama doesn't leave a dry eye in the house.
Logan achieves one leap at a time
Logan Wilson-Bryant loves taekwondo and he's pretty good at it too.
Sicario is one scary crime thriller
REVIEW: Sicario
Morsels of emotion
REVIEW: Bites, Skin Theatre, Dark Room, Saturday 19 September;
School holiday fun with fabric
A school holiday art programme held in Palmerston North will conclude with an exhibition at Te Manawa.
Why cats cough up furballs
So what is a furball?
Last Night of the Proms is back in Palmerston North
In Palmerston North, our own Last Night of the Proms is being held at the Regent on Broadway.
Ballet impresses at Regent
REVIEW: Royal New Zealand Ballet's has performed its magnificent new version of A Midsummer Night's Dream in Palmerston North
Art as a reflection of life
An exhibition set to open in Palmerston North tackles more than just art.
Te Manawa Concert series plays on
This month's Te Manawa Concert Series will be played by two Palmerston North musicians.
The art of dying
Centrepoint Theatre is about to open a new play that reveals the comedy at the heart of an everyday tragedy. Carly Thomas had a look at rehearsal.
Shock over boy's disappearance
Bags of evidence in search for boy
Man facing rape charges allowed at school
Burns sustained while trying to save life
Horror start to season for Small
New replica plane for Pahiatua
Inmate uses pencil in stabbing
Bindi Irwin leaves US audience in tears
Police resume search for missing Levin boy Alexander Fisher
Auckland woman refuses to budge from house sold to pay rates
Police seen with evidence bags in search for Alexander Fisher in Waitarere Forest
Childcare workers say some centres are like 'factory farming children'
US Christian group warns of Judgment Day on October 7
Convicted killer Helen Milner attacked
Recap: Rugby World Cup 2015: Fiji vs Uruguay #FIJvURU
Rugby World Cup 2015: Wallaby Michael Hooper banned from Wales clash


text: https://bbs.archlinux.org – I have this overscan problem as well.My configuration: main monitor DELL 1920x1200, second monitor - Panasonic Viera S1 TV connected via HDMI. Videocard - NVidia GeForce 210. I tried both nouveau and proprietary video drivers. And with both drivers my TV has overscan problem - some parts of the screen is outside of visible TV area.I googled and found this helpful article http://b.wardje.eu/2012/08/nvidia-linux-overscan.html I followed it and found that for proprietary driver I have to run$ nvidia-settings -a CurrentMetaMode="DFP-0: 1920x1200+0+0, DFP-1: 1920x1080+1920+0 { ViewPortOut=1820 (HowTos)


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I, and perhaps others, have posted this before. Given recent thread tension discussions I thought it might be good to post it again. It has really helped me over the years. sewing machine info
Edited by lyrad1 on 03/19/2013 08:54:23 MDT.
Thanks! That's very timely. I'm just starting and having been using standard thread for practicing on stuff sacks. I switched to the Gutterman Mara from DIY Gear Supply and have had some issues. I thought it might be the bobbin tension but haven't tried that yet. Since we are talking about beginner stuff here, what's up with the extended spool where the spool extends beyond the ends used with this thread? It has a larger inside spool diameter as well. Is that something used by industrial machines?
Edited by rlnunix on 03/19/2013 09:04:43 MDT.
Nice Daryl.. my gf did a kite workshop with the author of that page.
Nice, thanksExcept it really confuses about flat felled, mock flat felled, french seamsFirst, they have what they call a "mock french seam" which I would just call a flat felled seam - sew row of stitches, open fabric, fold over seam allowance twice to hide raw edges, sew another row of stitches.Then they have what they call a "French (or Flat Fell) Seam" which I would also just call a flat felled seam - same as above except the seam allowance for one fabric is half so the seam has one fewer layers of fabric. If you have thicker fabric or you're overlapping seams, having one fewer layers of fabric makes it easier to sew through.And they don't have a French Seam - sew two pieces together with a row of stitches, turn inside out and sew another row of stitches creating a fold hiding the raw edges. This seam is probably not useful for kite sewing but useful for clothes.
Jerry,I agree with your comments about the seam info. I'm sticking with the recently discussed BPL versions. Last thing I need is two seam protocols running through me head. Sometimes more info is too much. The thread tensioning portion of the link has been the most helpful to me.
> what's up with the extended spool It's a very standard spool for larger quantities of thread. The tubes out the end make it easy for the spool to spin on the support pin, and the thread does not get dirty from sitting on the machine.Mara: 'microfilament twisted thread made of 100% polyester'You can have some problems with tension and with kinking with 100% polyester threads. But I haven't tried Mara myself. I prefer a core-spun poly-cotton.Cheers
Thanks Roger. What thread (specific brand and size) do you use in your tents? My first real project is going to be a flat tarp. I think the sewing is going to be a heck of a lot easier than learning all the associated terminology, threads, needles, stitch types, etc.
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text:
Washington D.C., April 11, 2000 -- XM Satellite Radio Inc. (NASDAQ:XMSR) and Avis Rent A Car, a member of Avis Group Holdings, Inc. (NYSE:AVI), today announced that Avis will offer XM Satellite Radio to its extensive US customer base, making Avis the first car rental company to announce that it will offer satellite radio in addition to traditional AM/FM radio in its fleet. The two companies will also forge strategic co-marketing and promotional alliances. Details of the agreement were not announced.
"By offering XM Satellite Radio, Avis continues to be a pioneer in integrating the latest technology to benefit their customers," said Steve Cook, XM Satellite Radio's Senior Vice President, Sales and Marketing. "Avis is giving us a wonderful opportunity to build the XM brand by exposing our unique music and information programming to its broad and diverse driver base. We are committed to building awareness among consumers where they play, work and travel: in concert halls, theaters and sporting venues, in trucks, airplanes and boats. Now, partnering with one of the most respected brands in the car-rental industry, Avis, XM will reach potential subscribers on their vacations and business trips."
"Avis has a proud tradition of introducing technology to improve our customer's rental experience and we are delighted that our partnership with XM Satellite Radio builds on this tradition. XM enhances our ability to offer our customers some of the most technically advanced capabilities available in vehicles today, " said Michael Caron, Vice President, Quality of Service for Avis. "Our customers will have an enormous variety of music choices from rock to reggae, country to classical, as well as extensive sports and news coverage from USA Today, Bloomberg, the BBC, C-SPAN, One-On-One Sports and CNN/Sports Illustrated."
About Avis
Avis Group is one of the world's leading providers of comprehensive automotive transportation and vehicle management solutions, with strengths in car rental, vehicle leasing, and vehicle management services. Avis Group operates the second largest general-use car rental business in the world, with locations in the United States, Canada, Australia, New Zealand and the Latin American Caribbean region. Avis Group operates the vehicle management and fuel card businesses through three separate units: PHH North America, PHH Europe and Wright Express. The services of these units consist of vehicle leasing and a broad range of vehicle related fee based services. The Company manages a fleet of approximately 1 million vehicles and has over 4 million fuel and maintenance cards outstanding. Annually, on a pro forma basis, the Company generates approximately $4.0 billion in total revenue.
About XM Satellite Radio
XM Satellite Radio is developing a new band of radio. Starting the first half of 2001, XM Radio will beam up 100 channels of digital quality music, news, sports, talk and children's programming directly from its two powerful satellites to vehicle, home and portable XM-Ready radios coast to coast. Listeners will be able to drive from New York to Los Angeles, Chicago to Corpus Christi while continuing to listen to their favorite XM channels without searching the dial as they travel through unfamiliar parts of the country.
The XM sound will combine leading brand-name channels with distinctive formats produced in XM Radio's fully digital Programming Center by some of the country's leading artists, producers, programmers and radio format designers. XM-ready radios will be manufactured by such household names as Sony, Alpine, Pioneer Electronics Corporation, Delphi Delco Electronic Systems, Audiovox, Clarion, Mitsubishi Electronic Automotive America, Motorola and the Sharp Corporation.
The service will be easy to order, with XM-Ready radios available at car dealerships and consumer electronics stores across the country. The company has a long-term distribution agreement with General Motors to integrate XM-Ready radios into its vehicles commencing in 2001. XM will be available to truckers, boaters and airplane passengers through deals with Freightliner and Pana-Pacific, Marine Audio, and LiveTV respectively.
American Mobile Satellite Corporation (NASDAQ:SKYC) holds a controlling interest in the company, which is also backed by General Motors, Clear Channel Communications and DIRECTV, respectively, the leading car, radio and satellite TV companies in the US.
First there was AM, then FM and soon ... XM Satellite Radio. For more information, please visit XM's new website: www.xmradio.com.
Factors that could cause actual results to differ materially from those in the forward-looking statements in this press release include uncertainties associated with the launch of our satellites, the company's dependence on third party vendors, its continuing need for additional financing, as well as other risks described in XM Satellite Radio Inc.'s Form 8-K filed with the Securities and Exchange Commission. Copies of the filing are available upon request from XM Radio' s Investor Relations Department.
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Jennifer Markham
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text:
Joan Huff and Marian Yeates, The Cooper's Wife is Missing (Basic Books, 2000)
The term 'Witch Burning', generally speaking, is one that recalls a method of torture used to rid the local area of a person with an evil spirit, or one who is guided by bad influences and has been labelled a witch in return. This term has been used in a variety of idioms and circumstances both factual and personal.
In this case, the so-called witch-burning incident is a true life happening in Ireland in the 1800s. Bridget Cleary from County Tipperary was the last woman to be burned as a witch in Ireland. That was my usual take on the subject matter of The Cooper's Wife is Missing until it was pointed out to me that Ms. Cleary wasn't in fact a witch at all, but a fairy changeling. That, however, did not prevent her for meeting her eventual fate in the usual gory manner.
Information on Bridget Cleary in Ireland is quite scattershot, in so far as facts are few and far between apart from her own local area, and she has not achieved the notoriety of being raised as a fireside subject matter for conversation. In fact, prior to this book being published, the only mention of Bridget Cleary that I came across was on an album released in 1982 called Tryal by The Host a post-Horslips project from three of its best known members: Charles O Connor, Eamon Carr and Johnny Fean.
To get a chance to unravel the Bridget Cleary mystery even further offers a welcome opportunity to set some records straight and unveil the true facts behind her case. Ms. Cleary's death and the manner in which it was administered were both a pagan ritual and an exorcism of evil spirits. Due to the use of the ancient fairy trial to rid the fairy changeling of her so-called evil ways, Bridget Cleary's ultimate demise led her into local legend. This is a place she inhabits with other extremely localised heroines like Biddy Early in East Clare, whose healing powers were distributed from a potion brewed in her so-called 'magic bottle'. Again, as in Bridget Cleary's case, the influence of the fairy world was often alluded to in Biddy's magic powers and their success.
Writing-wise, Joan Huff and Marian Yeates use factual evidence to reenact Ms. Cleary's trial and torturous death. Having a strong factual grounding, they then re-create the events of time in a vivid and gripping manner. Pleasantly eschewing the overdramatic and any tendency to overkill, The Cooper's Wife is Missing spins an entertaining yet factually correct narrative. In short, by using this approach the authors make the story come alive again. For other authors wishing to revive ancient and forgotten stories from Ireland's past and turn them into interesting narrative works, The Cooper's Wife is Missing ought to be read as a template; such is its command of the historical narrative genre. The Cooper's Wife is Missing is not just a good read in terms of entertainment value. It is an important contribution to unveiling some hidden truths of the past. This is something we in modern 21st century Ireland are too often inclined to forget; or we have tended to rely upon half-baked remembrances from selective folk memory for our source information.
[John O'Regan]
GMR has also reviewed The Burning of Bridget Cleary by Angela Bourke.


text:
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Changes likely for Georgia elections
by Sarah Fay Campbell
Actions taken by the U.S. Department of Justice against the state of Georgia will mean a big change in elections next year.
A federal judge recently set the state's election schedule for federal elections — decreeing that there will be two months between the primary election and the runoff — rather than the typical 21 days. There will also have to be two months between the November general election and any needed runoff — possibly pushing the election of a new U.S. senator until after the Senate convenes for 2014.
The court-ordered election schedule only applies to federal elections, and doesn't affect state elections.
However, it's likely the state schedule will be changed to line up with the federal schedule.
The new schedule has the qualifying period for federal offices set for March 17 through 21. The primary would be June 3. The runoff election would be Aug. 5.
The general election would be Nov. 4, and a runoff would be Jan. 6.
The Georgia Secretary of State's office is working with Gov. Nathan Deal and the Georgia General Assembly to address the difference in the federal and state election calendars, said Cody Whitlock with the secretary of state's office.
The current state schedule has the primary in July, with the runoff 21 days later. Changing the state election schedule would require the passage of legislation in the General Assembly.
"That is a possible avenue," Whitlock said. Appealing the decision is another one.
"We are looking at all options," he said.
The issue that led to the action is the timeline for mailing out ballots to those living outside the United States. Under the Uniformed and Overseas Citizens Absentee Voting Act (UOCAVA), ballots must be mailed at least 45 days before an election. Since the runoff was only 21 days after the election, that was impossible.
The UOCAVA law has been in effect since 1986, but it was modified in 2009 by the Military and Overseas Voter Empowerment Act.
Having two separate election schedules would be confusing for voters, to say the least.
"I don't think that will happen," said Brant Frost V, chairman of the Coweta County Republican Party. "What seems most likely is that the legislature will have to set new dates."
Frost is concerned about the January runoff date, which could lead to a Georgia senator or representative not being elected until after the new Congress is in session.
He worries the scheduling issue could eventually lead to the state doing away with runoffs in the general election. Instead, the election would go to the top vote-getter, with no requirement the winner get 50 percent of the vote.
One way to fix that would be with "instant runoff" voting. With instant runoff, voters rank multiple candidates. If their first choice doesn't make it into the top two, votes are recounted with the second choice, and so on, until one candidate has more than 50 percent of the vote.
There are some members in the legislature who are looking into that possibility, Frost said. It would certainly be cheaper than the current system.
And Frost thinks it would cut down on some of the negativity in campaigns. "It may encourage people to be a little less confrontational about their candidates," he said. Candidates might spend less time saying negative things about their opponents and more time talking about why they are the right candidate. He's not sure instant runoff voting will ever be put into place in Georgia. "Some might say there is a sentiment in the legislature that they just don't want to try to do anything grand, anything bold," he said.
Frost said he thinks political parties should have more choice in how they determine their nominees. "My personal belief is that nomination by convention is cheaper," Frost said, and it would cut down on the amount of money candidates need to raise to be successful.
However, Frost said he's not sure the federal judge has the power to demand Georgia adopt a new election schedule.
"Some would say the federal court has no jurisdiction over this matter," he said.
Coweta County Democratic Party Vice Chairman Dee Crouch said she doesn't mind the stretched out voting schedule, but she thinks there might be better ways to make sure military ballots are counted, such as allowing electronic voting.
"We probably should make it easier for them to vote," she said. Crouch is an attorney and said that, at the state bar, "we do all of our elections by electronic voting."
We've got mechanisms in place so you can't vote twice," she said.
"I think we're currently sophisticated enough that we could do that."
The longer runoff season could certainly lead to a more bruising runoff campaign.
And some state pundits have said that could work in favor of Democrats, because it will almost certainly be Republicans who are involved in the bruising runoff fights.
Crouch doesn't see it that way. "If the Republicans want to beat each other up they can do that," she said. "I don't know that the Democratic candidate is going to benefit from that."


text:
Elmer F. Madar
Position: E
Height: 5-11 Weight: 185 lbs.
Born: November 28, 1920 in Sykesville, PA
Died: February 9, 1972 in Detroit, MI
High School: Northeastern
College: Michigan (school history)
Drafted by the Detroit Lions in the 20th round (176th overall) of the 1947 NFL Draft.
Weighted Career AV (100-95-...): 0 (14739th overall since 1950)
Our primary support comes from users like you. Sponsor this page for $5. Your message will replace this ad.
Output includes all games from 1920 to 2015.


text:
Hollie's Halloween Chowder
8 ounces sliced bacon, cut into 1/2 inch pieces
1 large sweet onion, chopped
2 cloves garlic, finely chopped
3 stalks celery, chopped
3 large carrots, chopped
6 medium potatoes, peeled and diced
1 teaspoon paprika
1/4 teaspoon crushed red pepper
1 10 oz. package frozen chopped broccoli
1 tablespoon unsalted butter
3 cups chicken stock
1 cup half n half
salt and black pepper
4 scallions, thinly sliced on a diagnol
garlic & cheese flavored croutons
Cook the bacon in a large sauce pan or dutch oven over medium heat until crisp...about 5 to 6 minutes. Transfer to a paper towel lined plate. Add a tablespoon of unsalted butter to the drippings, then add onion, carrot and celery and cook, stirring occasionally, until soft...about 5 to 7 minutes. Add potatoes and brocolli, garlic, paprika and red pepper. Season with salt and pepper. Cook another 5 minutes. Stir in the stock and half n half and bring to a boil. Reduce heat and simmer 20 to 30 minutes.
To serve, ladle the chowder into a bowl (preferrably one of Matt Granite's Ways 2 Save China Bowls!) Top with bacon, scallions and croutons!
Happy Halloween!


text:
U-M coach John Beilein talks to Nik Stauskas, left, Derrick Walton Jr. and Caris LeVert. / Brian Spurlock-USA TODAY Sports
Up next
Matchup: No.2 seed Michigan (27-8) vs. No.11 seed Tennessee (24-12) in the Sweet 16 of the Midwest Regional.
When: 7:15 p.m. Friday.
Where: Lucas Oil Stadium, Indianapolis.
TV/radio: CBS; WWJ-AM (950), WWWW-FM (102.9).
Line: Wolverines by 2½.
recruiting edge
A look at John Beileins last six recruiting classes at Michigan with ratings by Rivals.com:
Three-star recruits: Blake McLimans, Jordan Morgan, Matt Vogrich (No. 137 overall).
Four-star recruit: Darius Morris (No. 77 overall).
Three-star recruits: Tim Hardaway Jr., Jon Horford.
Four-star recruit: Evan Smotrycz (No. 59 overall).
Three-star recruits: Trey Burke (No. 142 overall), Max Bielfeldt.
Four-star recruit: Carlton Brundidge (No. 106 overall).
Three-star recruits: Spike Albrecht, Caris LeVert.
Four-star recruits: Mitch McGary (No. 30 overall), Nik Stauskas (No. 71 overall).
Five-star recruit: Glenn Robinson III (No. 11 overall).
Four-star recruits: Derrick Walton Jr. (No. 37 overall), Mark Donnal (No. 111 overall).
Five-star recruit: Zak Irvin (No. 24 overall).
Three-star recruits: D.J. Wilson (No. 135 overall), Ricky Doyle.
Four-star recruit: Kameron Chatman (No. 29 overall).
John Beilein does very little by following college basketballs herd.
Throughout his 36-year career he has cut his own path in team-building sometimes because he had to and sometimes because he wanted to.
Thats most apparent with Michigans current three-year elite run of two Big Ten titles, a national title-game appearance and another Sweet 16 appearance, which continues Friday against No. 11 seed Tennessee in Indianapolis.
While conventional wisdom involves reaching for the highest-rated recruits and fitting them together later, Beilein plans ahead, assembling the realistic jigsaw puzzle before they commit, let alone sign.
Where Beilein does a great job is he recruits a certain type of player, Scout.com national recruiting analyst Evan Daniels said this week. A player that fits his system. He has done a great job of finding those certain type of guys with certain attributes.
Beilein is so set in his ways, so determined that the incoming players fit a mold he wants socially, personally, mentally and then athletically that his scope doesnt extend far beyond that.
■ Related: Jeff Seidel: Sweet 16 reasons Michigan will beat Tennessee (or not)
■ Related: Could Michigan, MSU meet in NCAA championship? Las Vegas places odds at 25-to-1
In a gym evaluating a prospect, hes known to sit alone, not socializing or camera-posing.
Hes watching the details, the footwork, the hand placement, the shooting form.
Hes looking, projecting the bodies and anticipating the mind.
If theres something he can notice that someone else doesnt, thats his edge.
This Michigan team reflects his evolution: The barely known recruits Caris LeVert, Spike Albrecht, Jordan Morgan are handling a stage few thought they could. Glenn Robinson III became a recruiting gem, but Beilein embraced him before anyone else. Nik Stauskas, the No. 71-ranked player in his class by Rivals.com, has diversified his game beyond just shooting, becoming the Big Ten player of the year. And young players such as Derrick Walton Jr. and Zak Irvin have made significant strides from November.
Its the Beilein puzzle that nearly always seems to fit snugly in March.
The coach
Beilein often tells about the first time he had assistants, asking What do you guys do?
For years at the lower levels, he had done everything. Wash the laundry, drive the van, clean the floor, coach the team and find the players.
At Nazareth and Erie and LeMoyne, it was only his eyes.
Rising through the ranks, there were always better players he could reach.
But he wouldnt waver on his standard.
He didnt care how many stars they had, said John Mahoney, who worked for Beilein in 2005-10 at West Virginia and U-M. That wasnt one of the top five questions. He wanted to know what their SAT was, the second question was where was his birthday. He knew they could shoot it, pass it or whatever. He knew we would only bring him players like that.
■ Related: Dance party: Warren Buffett says next year's billion-dollar contest will be easier
■ Related: Ticket prices soar rapidly for NCAA East Regional games, including Michigan State-Virginia
If they were underdeveloped, even better, because he could mold them.
Just as his best players Mike Gansey, Trey Burke, Stauskas are rooted in self-confidence on the floor, he is off it.
Finding the young birthday may be one of his great tricks at least one that hes willing to share.
Its a catchphrase by now, mentioning a players youth, like sophomore LeVert, who wont turn 20 until August.
Beilein is always trying to find a younger player who he knows is undervalued and has great growth potential, physically and mentally.
Never an assistant himself, Beilein never recruited at the highest Division I level so he didn't fixate on already-developed high school players. He was more interested in projecting what they could do in college.
He loves kids who he sees the potential what he can do, said Mahoney, who watched Beilein drill fundamentals through the season, unlike many other coaches. We were recruiting a kid and I saw him maybe three times (first.) Then he did something with his footwork and (Beilein) said did you see that? No. Did you see the way he did something with foot? Im like, no. I just realized how much more there is to evaluate with a player.
Beileins magic: in the details.
The parent
At every level, Beilein answered critics who knocked his recruiting.
Burke is his most public proof.
The 2013 national player of the year was a three-star recruit during his tepid commitment to Penn State. When he backed out, U-M dove in.
The coaching staff knew they had a gem, but Beilein took his time.
I remember meeting him and you could just tell he was all about business, said Treys father, Benji Burke. Our first meeting was strictly business. Hey, we like your son, but went straight to the point. This is how we run our program, this is what were looking for. Is it a match for us? It wasnt like he just started recruiting Trey. It was about Treys character and making sure it was the type of guy he wanted in his program.
Thats where Beilein draws a firm line, as firm as any he has during the process.
A lot of coaches just look at talent, said Benji Burke, who has experience with other colleges from years as an AAU coach. Beilein wants to find good players, but with high character. He wants to know about the family.
The analyst
One of the common misconceptions about Beilein is that he only recruits lesser talented players that he can bring along.
Actually, at each level he has pursued players rated beyond his schools reach but only occasionally landed them.
When he arrived at U-M in 2007, a program without an NCAA tournament appearance in a decade, a dingy arena and no practice facility, he was only selling himself and only could get moderate talents like Zack Novak and Stu Douglass.
Then he grabbed Rivals No. 77 overall player in the 2009 class, Los Angeles point guard Darius Morris, and had a foothold.
But, despite heavy pursuit, couldnt get 2010s No. 28 overall player, Trey Zeigler. It was a painful blow, but he wasnt fazed.
Morris left U-M after two years and has been in the NBA for most of the time since. Zeigler will play at his third school (Texas Christian) in five years next season.
Michigan has chased many elite prospects over the years but few of them have panned out, even recently.
Yet the Wolverines keep pushing and Beilein keeps making do with underrated players like Tim Hardaway Jr. and building them up.
His highest-rated recruit was Robinson, who finished No. 11 in the 2012 Rivals national rankings. But when he committed before his junior high school season, he was an afterthought.
Its a lot about finding guys that fit what he wants to do, Daniels said. Hes also done a very good job of hitting Indiana and Ohio and those areas.
The revamped staff in 2010 helped.
LaVall Jordan grooms point guards and drew Walton. Jeff Meyer has decades of Indiana roots and now half of Michigans roster is from that state. Bacari Alexander has played, coached and lived in Michigan for most of his life.
There is good fortune center Mitch McGary was the No. 2 player in the country at one point and was connected to his best friend, Robinson but more often than not, its about Beileins eye.
Kameron Chatman is a perfect example, a guy coming in the 2014 class who fits what they want to do, Daniels said of next years highest-rated signee, a wing from Oregon. Zak Irvin is similar guy, Nik Stauskas. He loves those tall shooters.
And hell keep looking for them, his way.
Contact Mark Snyder: email@example.com . Follow him on Twitter @mark__snyder .


text:
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text:
Unprofessional Fridays: 10/09/2015
Become Premium to Watch
Don't play this game.
The Beginner's Guide offers a personal and sometimes eerie perspective on amateur game development.
Destiny's biggest expansion to date makes the game a whole lot more enjoyable and easier to recommend.
Game »
consists of 5 releases.
Released Apr 06, 1995
A quick burst of speed either forward or backward whilst in the air.
Anthropomorphism is the concept of an object, concept or character that has human qualities or traits, such as speech, a level of intelligence similar or higher than a human's and self consciousness. "Anthro" means "of human" and related to the concept of humanity.
When platform companies got the idea of selling their product in a colorful box they have included artwork and screenshots of various games that can be played on the platform.
A large ape-like creature that lives in the North-American Wilderness.
When one creature takes the blood of another creature, usually against their will. An excellent example is a vampire.
Feline animals commonly kept as pets. There are many different breeds and varieties.
A concept in games with multiple characters, a screen with pictures of all playable characters with the possibility of stat listings.
Typically found in fighting games, combos are a series of strung-together moves.
The continue is a classic gaming concept, and usually arises when the player "dies" or fails in the game. Usually some loss is tied to a continue, in a form of a "life" or something of other value.
The CP System is a family of arcade system hardware manufactured by Capcom for their arcade games from 1988 to 1999, including the Street Fighter II and Street Fighter III games.
Some games just won't settle for laughs. Some games make you want to cringe as you're busting a gut.
In fighting games, an Enhanced Special Move (also known as an EX Move) is a more powerful variation of a character's standard special move, though it is usually not as strong as a super attack.
Frankenstein's monster is the creature inspired by the Mary Shelley novel, Frankenstein. Usually creatures inspired by this theme are made from different body parts and almost always have bolts through their necks. They're usually naive and destructive.
Game Over originally appeared in pinball machines, and later, arcade machines. When players lose at a game, it is game over.
Whether it be Mario vs. Bowser, Jedi vs. Sith, Link vs. Ganon, or Elves vs. Orcs, the forces of good are in an eternal battle with the hordes of evil.
Health is a value that gauges how much damage players can take in a game before they die or pass out. Also known as life in some games. Health is usually represented by a bar or a percentage instead of an exact amount. Found in most non sport games
Hopping Chinese vampires that suck life force.
It's arguably the one move that symbolizes the medium to those outside it. The ability to jump, be it onto building, onto platforms, or onto skulls, is one of the all time most important abilities ever put in a video game.
Martial arts are a popular set of skills that many video game characters possess. Martial arts are the cornerstone of any fighting game, and have influenced many platforming and adventure games.
From Beat-em-ups to fighting games to modern FPS, one dude hitting another has made an enjoyable pastime.
A fighting game concept in which a player using a particular character can fight against either the CPU or another player using the same character.
Multiple endings is a term used to describe different outcomes or conclusions to a game based on the previous actions of the player.
Women of a religious order who commit themselves to a life style dedicated to their respective gods.
QSound is a recording/mixing process used in many audio recordings based on a processing algorithm and used to make sound appear to be in 3D whilst using only 2 speakers.
Old character animations used in newer games. Commonly seen in 2D fighters, annual sports title updates, and sequels appearing within the same console generation.
Characters that are designed to be scantily-clad.
This concept represents games in which a character changes or can change physically from one sex to the other during the course of the story or as part of gameplay.
Slashing weapons are designed to cut and slice rather than causing blunt trauma. Examples include swords, axes, claws, naginatas, or even whips.
Three games that are individually complete but are closely related in theme or sequence
The Undead is an umbrella term describing creatures that do not exhibit the key fundamental attributes that are associated with life, such as respiration, and blood circulation. They are divided into two main categories: Ethereal and Corporeal, depending on whether or not they have a body.
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text:
Visual System Development and Dysfunction
David R. Hyde
e-mail labpage
Rev. Howard J. Kenna C.S.C. Memorial Director of the Center for Zebrafish Research
Ph.D. 1985, Pennsylvania State University in Biochemistry and Molecular Biology
Post-doc 1985-1988: California Institute of Technology in Molecular Genetics and Neurobiology with Seymour Benzer
My lab studies a variety of processes associated with the zebrafish eye, including development of the retina and lens, retinal cell death (neuronal degeneration), and the role of adult stem cells and glial cells in regeneration of retinal neurons. The retina is an excellent model because it serves as an easily accessible portion of the central nervous system. Furthermore, the retina is not essential for the viability of the organism, which permits a variety of approaches to be used in studying its development and activity. The use of zebrafish in these studies permits a detailed analysis of retinal development because a large number of progeny are produced form a single pair mating and that the embryos develop externally, which simplifies their manipulation and analysis. Because the zebrafish retina grows throughout the life of the individual, a population of stem cells exists in the adult retina. There presence is partially responsible for the robust neuronal regeneration response that we are studying. We use genetic, cell biological, biochemical, and molecular approaches to examine the status of the retina and lens. These studies are directly relevant to an increased understanding of general neuronal processes and a variety of inherited human diseases, such as macular degeneration and retinitis pigmentosa in the retina and cataracts in the lens.
Analysis of retinal development
The zebrafish retina develops from a neuroepithelial sheet of undifferentiated cells that proceed through a coordinated wave of mitotic activity followed by cell differentiation to produce the mature laminated retina (Figure 1A). We are studying how a group of proteins, which are involved in generating the tight junction that separates the apical membrane from the basal-lateral membrane in neuroepithelial cells, are involved in the development of the eyes, the patterning of the different layers in the retina, and the differentiation of the various neuronal types in the retina. We are pursuing this work using a combination of classical and molecular genetic techniques. For example, we cloned the zebrafish pard3 gene (Wei et al ., submitted), which is alternatively spliced to encode two different proteins that localize to the apical side of the tight junction. Using molecular genetic techniques that block the translation of the Pard3 protein produced two phenotypes. The first phenotype is cyclopia, which is the fusion of the eyes. We found that the absence of Pard3 expression in the developing ventral diencephalon in the brain resulted in cell death and the inability of the developing eyefields to separate. Later, the retina exhibits a lack of lamination (Figure 1B), even though all the different neuronal classes are present in the disorganized retina. We are continuing to identify and characterize additional proteins that are expressed in the tight junction. While these proteins are all expressed at the tight junction of the neuroepithelial cells, we found that loss of these proteins results in a variety of different developmental phenotypes. Further characterization of these phenotypes and protein interactions will reveal the role of these proteins in retinal and brain development.
Figure 1. A wild-type retina (A) and a retina that develops in the absence of the Pard3 protein (B). The wild-type retina is laminated and contains the outer nuclear layer (ONL), which is where the rod and cone cell nuclei are located, the inner nuclear layer (INL), where the stem cell population is located, and the ganglion cell layer (GCL). These three nuclear layers are separated by two synaptic layers, the outer plexiform layer (IPL) and inner plexiform layer (IPL). The retina that develops in the absence of the Pard3 protein is not laminated and lacks any neuronal organization.
Retinal degeneration and regeneration
We demonstrated that treating albino zebrafish with intense light causes apoptosis (cell death) of the rod and cone cells. However, cells in the underlying inner nuclear layer begin to proliferate and migrate along Muller (glial) cells to the outer nuclear layer where they differentiate into both rods and cones (Vihtelic and Hyde, 2000). The ability of these inner nuclear layer cells to differentiate into rod and cone cells after light damage suggests that they are pluripotent and may represent stem cells. We recently found that the light-induced damage varies in different regions of the retina. Surprisingly, retinal regions that contain primarily rod cell death exhibit low levels of proliferating inner nuclear layer cells, while regions that contain excessive rod and cone cell death exhibit large numbers of proliferating inner nuclear layer cells. This suggests that the cell proliferation and subsequent neuronal differentiation is dependent on the type and amount of neuronal cell death in the overlying retinal layer. Recent experiments also demonstrate that the Muller glia also begin to express genes and proteins that are expressed in early neuronal differentiation, which suggests that the Muller glia begin to take on a neuronal identity in response to the light-induced retinal degeneration. To further examine the neuronal regeneration response, we recently began injecting ouabain into the zebrafish eye, which results in cell death of all the neuronal classes throughout the retina (Figure 2). Within seven days of the massive cell death, there is a large increase in cell proliferation that results in the regeneration of all the neuronal classes in the retina (Figure 2). This further supports the idea that the proliferating inner nuclear layer cells are stem cells and possess the capacity to differentiate into any retinal cell type. We are very interested in determining the breadth of neuronal classes that can be regenerated from the inner nuclear layer stem cells, the mechanism that permits these stem cells to recognize which neuronal classes are lost, and the processes that control the differentiation of one neuronal class over another class. We are employing gene microarray experiments and genetic screens to identify the genes that are involved in these processes.
Figure 2. Ouabain-induced retinal degeneration is followed by regeneration. A control retina exhibits the standard lamination pattern. Four days after ouabain injection, the ganglion cell layer (GCL) is dramatically reduced and the outer and inner nuclear layers (ONL and INL, respectively) are disorganized. Seven days after ouabain injection, the three nuclear layers can no longer be differentiated. By 14 days, the ONL is reorganizing. By 90 days after ouabain injection, the retina is again laminated. A few misplaced nuclei are present in the synaptic layer (IPL), which may be due to their migration between nuclear layers or a stable displacement.
Our identification that the Muller glial cells begin to express neuronal cell proteins after the light-induced damage suggests that they may dedifferentiate or trans-differentiate into neurons. A transgenic zebrafish line that expresses Green Fluorescent Protein (GFP) in neuronal precursor cells, also exhibits GFP expression in a subset of Muller glial cells after light-induced damage. A subset of radial glial cells in the mammalian brain has also been suggested to differentiate into neurons during specific periods of brain development. Thus, we are interested in confirming if the Muller glia can differentiate into retinal neurons and elucidating the neuronal classes can be derived from these glial cells. To perform these experiments, we are developing novel transgenic techniques that will express GFP from a Muller glial-specific promoter and then switch the GFP expression to a ubiquitous promoter to continue expressing the GFP marker in any cell that is differentiated from the Muller glial cell. This novel technology will be useful in addressing a number of interesting questions in both neuronal regeneration and in retinal and brain development.
Transgenic techniques to characterize retinal degeneration and regeneration
We cloned several different genes that are expressed in different neuronal classes or the Muller glia in the zebrafish retina (for example, Vihtelic et al., 1999). We isolated the upstream regions of these genes to identify the essential elements of the corresponding promoters, with the intent to generate transgenic zebrafish. This involves cloning the GFP gene downstream of different promoter sequences and then cloning these constructs into a transposable element and microinjecting them into zebrafish embryos. The GFP expression then reveals the expression pattern that is associated with a specific promoter fragment. Examples of various promoters are shown in Figure 3. In Panel A, a rhodopsin promoter directs GFP expression in only the rod photoreceptor cells (Kennedy et al., 2001). In Panel B, an ubiquitous promoter drives GFP expression throughout the zebrafish embryo (a non-transgenic embryo shows the autofluorescence in the residual yolk sac). We are also cloning promoters that are active in only Muller glial cells, lens epithelial cells, and neuronal precursor cells. In addition to expressing GFP from these promoters to mark different cell types to characterize development and regeneration, we intend to express toxins from these promoters to ablate specific cell types to examine their role in development, regeneration, and retinal function (such as visual behaviors).
Figure 3. Transgenic zebrafish developed at Notre Dame. A transgenic zebrafish line that expresses Green Fluorescent Protein (GFP) from the rhodopsin promoter in only the rod photoreceptor cells (A). The GFP is expressed from the ef1 ubiquitous promoter and is found throughout the zebrafish embryo (B, top). A control zebrafish embryo shows autofluorescence in the residual yolk sac (B, bottom).
Gene microarray analysis during retinal regeneration
We recently initiated gene microarray studies of mRNA expressed in the retina during light-induced retinal degeneration and regeneration. These experiments reveal that a large number of genes alter their expression in response to the light treatment. The patterns suggest an increased number of cells reentering the cell cycle, an increased number of neuronal precursor cells and their movement through the differentiation pathway, and an increased number of migrating cells. These results are consistent with our immunohistochemical analysis of the regenerating retina. We are now utilizing real-time PCR to confirm these changes in gene expression levels.
We will extend these analyses in three specific ways. First, we will examine different regions of the light-damaged retina that correspond to primarily rod cell damage versus rod and cone cell damage. We hope that this will reveal differences between rod and cone cell regeneration and may elucidate the signals and mechanisms that are involved in these pathways. Second, we will use laser capture microdissection techniques to isolate specific retinal cells and isolate mRNA from these cells to use as the probe for the microarrays. We hope that this will reveal gene expression changes in specific cell types, such as the inner nuclear stem cells or the Muller glial cells. Third, we will isolate mRNA from ouabain-treated retinas (which exhibit massive cell death throughout the retina, followed by regeneration of all the neuronal classes) to use as the probe for the microarray. Comparing the expression profile from this tissue and the light-damaged retina will reveal gene expression changes that are specific to the rod and cone cell regeneration and those expression changes that are specific to the regeneration of neuronal classes other than rod and cone cells. These results will reveal candidate genes that may be essential in signaling stem cell proliferation, regulating stem cell proliferation and differentiation, and neuronal precursor cell migration. These candidate genes will ultimately be examined using genetic techniques.
Selected Publications:
1. Wei, X., Cheng, Y., Luo, Y., Shi, X., Nelson, S., and Hyde D.R. (2004). The zebrafish Pard3 ortholog is required for separation of the eye fields and retinal lamination. Dev. Biol. 269: 286-301.
2. Vihtelic, T.S., Yamamoto, Y., Springer, S.S., Jeffery, W.R., and Hyde, D.R. (2005). Lens opacity and photoreceptor degeneration in the zebrafish lens opaque mutant. Dev. Dyn. 233: 52-65.
3. Shi, X., Bosenko, D.V., Zinkevich, N.S., Foley, S., Hyde, D.R., Semina, E.V., and Vihtelic, T.S. (2005). Zebrafish pitx3 is necessary for normal lens and retinal development. Mech. Dev. 22: 513-527.
4. Thummel, R., Burket, C.T., Brewer, J.L., Sarras, M.P., Li, L., Perry, M., McDermott, J.P., Sauer, B., Hyde, D.R., Godwin, A.R. (2005). Cre-mediated site-specific recombination in zebrafish embryos. Dev. Dyn. 233: 1366-1377.
5. Vihtelic, T.S., Fadool, J.M., Gao, J., Thornton, K.A., Hyde, D.R., and Wistow, G. (2005). Expressed sequence tag analysis of zebrafish eye tissues for NEIBank. Mol. Vis. 11: 1083-1100.
6. Thummel, R., Bai, S., Sarras, M.P., Song, P., McDermott, J., Brewer, J., Perry, M., Zhang, X., Hyde, D.R., and Godwin, A.R. (2006). Inhibition of zebrafish fin regeneration using in vivo electroporation of morpholinos against fgfr1 and msxb. Dev. Dyn. 235: 336-346.
7. Wei, X., Luo, Y., and Hyde, D.R. (2006). Molecular cloning of three zebrafish lin7 genes and their expression patterns in the retina. Exp. Eye Res. 82:122-131.
8. Vihtelic, T.S., Soverly, J.E., Kassen, S.C., and Hyde, D.R. (2006). Retinal regional differences in photoreceptor cell death and regeneration in light-lesioned albino zebrafish. Exp. Eye Res. 82:558-575.
9. Semina, E.V., Bosenko, D.V., Zenkevich, N.A., Soules, K.A., Hyde, D.R., Vihtelic, T.S., Willer, G.B., Gregg, R.G., and Link, B.A. (2006). Mutations in laminin alpha 1 result in complex, lens-independent ocular phenotypes in zebrafish. Dev. Bio. 299:63-77.
10. Shi, X., Luo, Y., Howley, S., Dzialo, A., Foley, S., Hyde, D.R., and Vihtelic, T.S. (2006). Zebrafish foxe3: roles in lens morphogenesis through interaction with pitx3. Mech. Dev. 123:761-82.
11. Kassen, S.C., Ramanan, V., Montgomery, J.E., Burket, C.T., Liu, C.G., Vihtelic, T.S., and Hyde, D.R. Time course analysis of gene expression during light-induced photoreceptor cell death and regeneration in albino zebrafish. J. Neurobiol. in press.
Research Associate Professor
Thomas S. Vihtelic, D.V.M, Ph.D. (Ph.D. University of Notre Dame, postdoc: University of Chicago and Harvard University, Massachusetts Eye and Ear Infirmary)
Postdoctoral Researchers
Chris Burket, Ph.D., Worcester Polytechnic Institute (2002)
Ryan Thummel, Ph.D., University of Kansas Medical Center (2004)
Travis Bailey, Ph.D., Baylor College of Medicine (2006)
Graduate Students
Shane Fimbel, Wabash College (2002)
Sean Kassen, Alma College (2003)
Yiying Luo, Fudan University (2002)
Jacob Montgomery, Bemidji State University (2003)
Taylor Murphy, California State University (2005)
Sandra Springer, University of Maryland (2003)
Suzyanne Guzicki


text:
Cursed Lotto Numbers from Lost Win Real-Life Lottery!
Entertainment Jan. 5, 2011 AT 1:17PM
Spooky jackpot!
Four of the six winning numbers in Tuesday's Mega Millions lottery should be very familiar to Lost fans: They matched the same numbers that haunted "cursed" castaway Hugo "Hurley" Reyes (played by Jorge Garcia), who won $114 million using 4, 8, 15, 16, 23 and 42.
In the real-life $355 million jackpot, the numbers were 4, 8, 15, 25, 47 and 42 (the Mega Ball number).
Anyone who played Hurley's famous digits won about $150.
PHOTOS: The biggest headlines of 2010
On ABC's hit, Hurley is plagued by both fortune and misfortune via those numbers throughout his life.
Tweeted show creator Damon Lindelof: "9,078 people played Hurley's numbers in the MegaMillions tonight, each winning $150."


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Holiday Experts is a successful, fast growing travel company
using high quality home based agents to deliver exceptional customer service. We are growing rapidly through innovation and investment in internet marketing techniques. In fact we are one of the finalists for the Travel Weekly Globe Awards Most Innovative Agencies and Homeworker of the Year.
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In wintertime, Scotch, Irish, and Japanese whiskeys each deserve their own section on your bar, but with the sun closer, there's less need to warm your insides; you can roll with one well-chosen representative from each. The Japanese are now producing hooch to rival the Scots, and the Yamazaki 12-Year is a lovely ambassador (and great value), aged in bourbon barrels, sherry wood, and Japanese oak. Lots of Jameson fans jump from the 12-Year to the 18, forgetting Jameson Gold, the brightest and creamiest of the range (and the only one to use virgin American oak). And though the snow has melted, and we can extinguish the peat fires, make an exception for the subtle, dry smoke in Highland Park's 25-Year Old single malt. If you're gonna splurge, do it here. Taking in the summer stars, cigar in hand, tongue abuzz with rich toffee and salted chocolate. You'll be glad you did.
Go-To Cocktail: Japanese Manhattan
For an elegant, light-footed variation on a Manhattan that's pitch perfect for spring, try this creation from Julie Chang, Eladio Huitzil at the cigar-friendly Bar and Books (where the emphasis is decidedly on bar).
2 oz Yamazaki 12-Year
¾ oz Dry Vermouth
½ oz St. Germain
2 Dashes Angostura Bitters
Prepare all ingredients in a mixing glass. Stir and strain into a chilled cocktail glass. Garnish with an orange peel.
Mixing Glass
Julep Strainer
Bar Spoon
Fruit Peeler
Cocktail (Martini) Glass


text:
All-College needs Bedlam
LaSalle, the 1954 NCAA basketball champion, and Texas-El Paso, the 1966 NCAA champion, will play OSU and OU in the All-College Classic on Dec. 20. Which would be a grand thing if it was Dec. 20, 1954, or Dec. 20, 1966.
But on Dec. 20, 2009, the Explorers and Miners, despite fielding solid teams in solid conferences, won't generate any excitement downtown. Which is why it's time to again call for a Bedlam All-College. An OU-OSU Christmas. Cowboys vs. Sooners at the Ford Center in December, a game which would serve as an appetizer to the two Big 12 showdowns later in the season. And finally, we have a coach who doesn't summarily dismiss the idea. I trotted out this plan in 1998 and again in 2001; both times, Eddie Sutton and Kelvin Sampson shot it down. But Travis Ford, 16 months into his Oklahoma State coaching era, is intrigued by the idea. "It's something to talk about," Ford said. "I like the fact it does get some excitement in the month of December." I have no idea what the other new face of Bedlam, Jeff Capel, thinks. He declined comment, deferring to athletic director Joe Castiglione. Which is a dodge; college basketball coaches control their own schedules. But Castiglione used the right word — "intriguing ... something to think through, for sure." Excellent. Now we've got decision-makers at least willing to discuss something that would be great for college basketball in our state. "The fans would like it," Ford said. "It would create some excitement." Heck, you could play a women's Bedlam and make it a doubleheader. Fans would pay steep prices; the schools could increase their season tickets by tying them into All-College availability. RPI and strength of schedule for NCAA Tournament seeding would be enhanced. Scheduling would be enhanced, since a Bedlam showdown would free the schools from playing a return game somewhere the next year. Both Castiglione's and Ford's only concern: They don't want to take away from the two conference games already. "I can't answer whether it would or not," Ford said. I can answer. No way would it take away from Bedlam games later in the year; it would only enhance them. Bedlam already is one of college basketball's better rivalries. A third game, played on the 38th parallel of the Ford Center, would elevate the series nationally. ESPN would eat it up. Think Red Sox and Yankees. The ancient rivals played 12 times a season, then several years ago baseball decided to get serious and start playing more games people care about.


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Cyril's to keep liquor license through September
The New York State Liquor Authority ruled Cyril's license would be revoked when it expires in October after the eatery was slapped with dozens of health and building violations.
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MACDONOGH, Felix. Hermit in Edinburgh, The (1824)
Contemporary Libraries
Please click here for a list of abbreviations
used for the Circulating Libraries pages.
Circulating Libraries:
Aberdeen Public Library, Broad Street, Aberdeen. Additions
1. (Catalogue: 1838)
Bettison's Library, High Street, Cheltenham. Additions
1. (Catalogue: 1829)
Robert Kinnear's Circulating Library, 29 Frederick Street,
Edinburgh. Additions 4. (Catalogue: 1825)
Mackenzie's Circulating Library, 129 Pilgrim Street, Newcastle-upon-Tyne.
(Catalogue: 1832) [2x]
Gerrard Tyrrell Circulating Library, Lower Sackville Street,
Dublin. (Catalogue: 1834)
Subscription Libraries:
Edinburgh Subscription Library, Edinburgh. (Catalogue: 1833)
Manchester Subscription Library, Manchester. Additions 1. (Catalogue:
Summary: 5 out of 10 possible Circulating Libraries; 2 out
of 3 possible Subscription Libraries.
Overall: 7 out of 13 possible Libraries.
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A Very Special Wine Boutique
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Wine is older than history. Humans didn't invent wine. We discovered it. PHILIP SEL...
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Andrew's Picks
2004 JJ Prum Wehlener Sonnenuhr Kabinett
A textbook kabinett--light, crisp and bursting with floral, peach and citrus flavors. It's balanced, with a tangy finish that p...read more
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A blend of 70% Cabernet Sauvignon, 15% Merlot and 15% Petite Verdot aged for 14 months in barrique, they make 80,000 bottles on...read more
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(93 Points) Deep garnet. Very pretty plum and berry aromas, with hints of honey and toffee. Turns to custard. Full-bodied, swee...read more
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text:
Sheridan Wins Mock Election at Temescal Canyon High School
October 31, 2014 Tim Sheridan, the Democratic candidate for California's 42nd Congressional District, soundly defeated 20-year incumbent Congressman Ken Calvert in a mock election at Temescal Canyon High School in Lake Elsinore earlier this week. Sheridan earned 56% of the vote against 44% for the long-term incumbent. About 1,500 students cast votes. "Needless to say,"(…)
Sheridan Campaign Confirms Filing Against Incumbent Calvert
October 31, 2014 The Committee to Elect Tim Sheridan to Congress confirmed today that a complaint has been filed against 20-year incumbent Congressman Ken Calvert with the House Commission on Congressional Mailing Standards for violating 39 U.S.C. Sec. 3210. Specifically, the complaint alleged that Mr. Calvert inappropriately mailed postcards, at taxpayer expense, within 90 days(…)
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text: OK, well I am in lack of a grinder and i need my bud finely ground for vaping. Anybody know a way to get my bud finely ground without having to use my fingers? This bud isnt exactly easy to crumble up, it's hard and somewhat compact (it's not brick weed or schwag tho). And I just dont like using my fingers in general. Any suggestions? Thanks, Crim