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Next Meeting: 'WCC On Tour'
Our meetings are held at 8pm on the 2nd Tuesday of each Month. The next meetings are:
- October the 13th: The Mason's Arms, 169 Battersea Park Rd, London, SW8 4BT
November the 10th: The Brewers Inn, 147 East Hill, London, SW18 2QB
To keep things interesting and to make ourselves as accessible as possible to LCC Members across our borough, WCC is now 'On Tour'. We are alternating our venue each month. If you have a pub you'd like us to visit, join us at our next meeting and let us know!
Wandsworth LCC
This website is the central repository for all cyclists in the Borough of Wandsworth, South West London. Every LCC member who lives in Wandsworth is automatically a member of Wandsworth Cycling Campaign. If you have information to share with the group, local concerns or simply wish to participate, you can get in touch here!
Why is cycling such a good choice?
- It helps you keep fit, both mentally and physically.
- It is low-cost with no congestion charge, petrol or fares to pay.
- It is usually much quicker than a car or public transport for short distances -a bicycle is ideally suited for trips of under 5 miles.
- It lets you plan your life because you know exactly how long each journey will take.
- It gives independence and freedom to travel where and when you choose.
- It is entirely non-polluting, so you are helping to improve air quality for us all.
- It reduces road congestion and the need for consuming valuable green spaces.
And not many other Londoners would say that they enjoy their journey to work! If you would like more information about our activities, or anything else on this website, please contact us.


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PIC: Jen Schefft Drops 40 Lbs Post-Baby!
Sweatin' her way back to a bangin' bod!
Former Bachelorette star Jen Schefft was overjoyed when she and hubby Joe Waterman welcomed their first child, daughter Mae, in November 2010.
PHOTOS: Jaw-dropping post-baby bods
Less joyous? Slimming down post-baby -- and finding a fitness routine that worked for her. When former PR exec Schefft, 35, got on the treadmill three months after giving birth, "I thought I was going to die!" she tells the new Us Weekly, out now. "I didn't realize how out of shape I was."
While carrying Mae, a nausea-plagued Schefft admits she "threw in the towel" with her diet -- indulging in Chipotle, pancakes and cheeseburgers daily.
VIDEO: Inside baby Mae's adorable Alice in Wonderland nursery
How'd she finally find a way to get back her body -- dropping 40 pounds and fitting into a size 4 again? Bikram yoga, as suggested by husband Waterman -- and a diet defined by moderation rather than restriction.
Thanks to super-sweaty Bikram sessions, "I dropped 25 pounds right away. Those last 15 took a while," Schefft admits. "And I still have about 5 to go. I want my abs back!"
PHOTOS: Bachelorette stars flaunt their bikini bods
For more on Schefft's amazing slimdown, pick up the new Us Weekly, out now!

subset: commoncrawl


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- No Closings Found
Severe Weather
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Published On: Sep 20 2011 11:36:58 AM EDT Updated On: Oct 16 2012 10:43:52 AM EDTSorry, Flash is not supported.
The views expressed are not those of this site, this station or its affiliated companies. By posting your comments you agree to accept our terms of use.blog comments powered by Disqus


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Percona Server, an enhanced drop-in replacement for MySQL that will allow queries to run faster and more consistently and to consolidate servers on powerful hardware, is now at version 5.5.30-30.2.
Highlights of Percona Server 5.5.30-30.2:
• Priority connection scheduling for the Thread Pool was implemented in Percona Server for MySQL;
• The libjemalloc library will be provided with Percona Server for MySQL;
• A few performance issues have been resolved;
• The drop table performance feature was removed;
• Several yum dependencies, that were causing conflicts in CentOS 6.3, have been corrected;
• Innotop and its InnoDBParser Perl package have been removed from the Debian installation.
A complete list of changes and updates can be found in the official announcement.
Download Percona Server 5.5.30-30.2 right now from Softpedia. According to the developers, this is now the current stable release in the 5.5 series.


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PAWTUCKET ŌĆö While saying that he intends to be open minded about hearing options at an upcoming meeting, Mayor Donald Grebien has made it clear that he thinks the School Department must take responsibility in addressing an unexpected deficit of $1.5 or more that has arisen as the 2012 school budget is being closed out.
PAWTUCKET ŌĆö A Pawtucket man with convictions for attempted murder and narcotics charges in Puerto Rico was arrested by State Police Monday under a new law that makes it a crime to possess body armor after a crime of violence.
Antonio E. Limardo, 34, of 42 Webster St., was also in possession of a 9mm handgun, a knife and pepper spray, state police said.
Read more in our print edition.
PAWTUCKET - Kenneth J. Lawrence, 51, of Pawtucket, RI and West Yarmouth, MA passed away unexpectedly on Saturday, August 4, 2012. He was the beloved husband of Karen A. (Kut) Lawrence, they would have celebrated their 29th wedding anniversary in September.
Born in Providence, he was the son of Donald R. and Patricia A. (Perry) Lawrence of Pawtucket.
PAWTUCKET - BALCOM, Myrtle M., 84, of Pawtucket passed away on August 3, 2012at the Pawtucket Skilled Nursing Center.
The funeral for Myrtle will be Thursday, August 9, 2012 in the MANNING-HEFFERN FUNERAL HOME, 68 Broadway, Pawtucket at 10:00 AM. Calling hours will be Wednesday from 5:00 to8:00 PM. Full obituary can be found at
PAWTUCKET - Martha F. (DeRoche) Bibby-Boucher, 83, passed away surrounded by her loving family on Sunday, August 5, 2012. She was the beloved wife of the late Conrad "Butch" O. Boucher.
Born in Pawtucket, she was a daughter of the late Wilfred and Annie (Tally) DeRoche. She leaves three children, Sandra Mellen, Walter Bibby and Michael R. Bibby, Sr. all of Pawtucket; 8 grandchildren and 11 great-grandchildren.
PAWTUCKET - Annette Lust passed away at the Philip Hulitar Inpatient Center on August 3, 2012 at the age of 70.
She is survived by her husband Paul Mowrey, brothers George and Dirk, sisters Hannelore and Angelika and children Paco, Gustavo, Friedrika and Stephanie, together with 6 grandchildren and 16 nieces and nephews.
CUMBERLAND - Manuel Ferreira, 74, of Broad Street passed away Friday in the Philip Hulitar Hospice Center, Providence. He was the husband of Adozinda (Saraiva) Ferreira
Born in Pinhancos, Portugal he was the son of he late Antonio and Maximina (Santos) Ferreira. He resided in Cumberland for the past 10 years, previously residing in Pawtucket.
He was employed at the former Central Braid, Central Falls until his retirement.
PAWTUCKET: Clarisse Doyon, 84, passed away at Grandview Nursing Home on Saturday, August 4, 2012. Born in Central Falls, RI, she was the daughter of the late Eugene and Marguerite (Dion) Doyon.
PAWTUCKET - George J. Audette, 91 of Pawtucket died Friday at the Miriam Hospital. He was the husband of the late June (Voyer) Audette. Born in Pawtucket he was the son of the late Joseph D. and Diana (Bourgeault) Audette. He was a Pawtucket resident his entire life.
PAWTUCKET - Martin, Jean, 67, of Pawtucket, and formerly of Central Falls, passed away Saturday, August 4, 2012. She was the wife of Joseph W. Martin Jr.
Born in Providence, she was the daughter of the late Thomas and Mary (Searles) Burns. She was a school bus monitor in Central Falls School Department for eighteen years, retiring in 2004.
Nights like the one that transpired at McCoy Stadium Saturday night donŌĆÖt come around too often ŌĆ"
PAWTUCKET ŌĆö As much as he enjoyed his two-year stint with the Pawtucket Red Sox, Wade Boggs wanted no part of the Triple-A ball club upon reaching the parent team in 1982.
Any ballplayer will tell you that his goal is not just to make the majors, but to make it and stay there, leaving the minor leagues in their rear-view mirror for good. When BoggsŌĆÖ promotion came after almost six years in the minors, he felt he had learned everything he needed to begin his big-league career.


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It saddens me to say this, but it appears Prick Magazine is for sale. Prick Magazine Publisher Chuck B. put this message on the Prick Magazine Facebook page yesterday:
Ok everyone the time for the announcement is now. After being fired and rehired then fired again by a crazy old man that can't even check emails, I have not been producing any other magazines for Art and Ink/Outlaw Biker publications for over a month now. Three or four issues have come out since my termination. I do not work well with bosses I guess. Now on to the PRICK announcement. Without the paycheck from the other camp I am left with some harsh conditions.
We have been stiffed over $18 thousand dollars over the last few years on advertising in PRICK and I have been losing about $2 to $3000 every time I put out an issue for the last 2 or more years. I have always done it for the passion of the arts because I was financially secure before I started PRICK. Now my money is gone and so is my passion to support those who don't actually support me. Therefore PRICK as a magazine/title is FOR SALE and I will be taking it out of print as of now. The online presence will stay functioning but I am retiring from the role as publisher and current events journalist of the tattoo community. We will be producing a book or box set of books. "A PRICK's Dozen" A 12 year history of tattoo lifestyle thru the pages of PRICK Magazine. Pre orders and a kickstarter fundraiser will be up soon on the website. Any unfulfilled promises of articles, advertiser or subscriber issues will be fulfilled thru the pages of the book or by receiving a copy or by our online venues. Sorry folks but I have left my blood and money all in the ring and this fight is over for me personally. Maybe someone can come along and buy out the title and save the day and keep things rolling but I woefully though in the towel on producing current event tattoo magazines for a living. I will be pursuing my own art career along with completing the book and hope to get your support in this next chapter.
Yours truly,
Chuck B.
PRICK Magazine publisher.


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Watch Childish Gambino Perform 'Shadows', Talk About 'Community' and Tyrese on 'Arsenio'
More Hip-Hop/R&B News
Beyoncé Causes Controversy with Challenger Explosion Sample on 'XO'
Jhené Aiko, a Star On Her Own Terms — With a Little Help From Drake
Nicki Minaj, Drake, Migos: Three Brand New Songs to Put on Your Playlist
Radio Stations
Donald Glover, aka Childish Gambino, got comfy on Arsenio Hall's couch last night (Nov. 12) to talk about why he's not really a rapper, why he doesn't need a boss and what he really meant when he said he didn't want to be Tyrese.
Like Tyler, the Creator before him, he treated Arsenio's studio like his personal living room, sitting cross-legged throughout their chat, which had him explaining why he really left Community. "I just wanted to do something else, that was it," he said. "There's really not much more to it… I just wanted to do other stuff."
It wasn't to pursue his rap career full time because as Glover explained, "I don't consider myself a rapper. I don't think I'm a rapper. I can rap, but I don't think I'm a rapper. I want to do other stuff." Watch the full interview below.
He even joked, "Rappers don't want to be rappers…It's true. I don't think any rapper wants to be just a rapper."
Glover also spoke out about those Instagram confessions saying that he didn't think they'd be a big deal, but that he stands behind what he wrote, specifically about caring what people think. "It's always important to care what other people think because that's what connects us," he explained. "I want to do the best thing I can and sometimes, you know, I'm insecure, I feel weird about a bunch of stuff…but I wish I didn't feel that way so much so it didn't stop me from doing what I really love to be doing because everybody's afraid, so afraid, of offending or being misunderstood and that's going to happen."
RELATED: Listen to Childish Gambino Croon About Love on New Song 'Melrose'
Glover also urged everyone to be their own boss and pursue whatever career they want. "Who's stopping you?" Glover asked. "Nobody's stopping you anymore, but we're afraid to move on. That's why there's so much nostalgia on the Internet…because we don't want to look forward, because that's scary…but we gotta move on because it doesn't make sense to stay."
He also addressed his confession, "I'm scared I'll be Tyrese," which wasn't as bad as it sounded.
"What I meant was I want to be okay with where I'm at, like I never want to settle. I never want to be like just happy with where I'm at, I always want to be going for better," he explained, right after he admitted he was surprised that Tyrese hadn't commented on what he said and was concerned the actor/model/singer was going to send a Transformer to kill him.
Glover also suggested that his fans stop trusting the Internet for information about him, noting that there are people out there who think he's Danny Glover's son. "I am not," he said. "But I mean, that's fair."
Glover also performed his new song "Shadows" off Because the Internet, out Dec. 10, where else, but on the couch with Arsenio looking on.
Watch the performance below.


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- Written by MiddleEasy @MiddleEasy
So it looks like Silverstar is using Nazi imagery to push their product
Here we go again with this nonsense. After we exposed that Hoelzer Reich openly used Nazi imagery to promote their line of MMA apparel, we have another culprit who blatantly places Nazi insignia on their line -- and it's disgusting.
For those of you who are not familiar with the skull placed on the shirt that Clay Guida is rocking in the recent Fight! Magazine interview, it's called a Totenkopf or 'Death Head' and Julius Schreck, the leader of Stabswache (Adolf Hitler's body guard unit) adopted the skull for his unit. It later grew to be associated with Hitler's Schutzstaffel (SS) and then eventually became widely associated inside the entire Nazi regime. Now it's been a staple for Neo-Nazi organizations and Eastern European skinhead groups. This same skull was also used within the Hoelzer Reich brand.
I'm sure that a statement will be released sometime this week claiming the designer of the shirt thought it was just 'a really cool skull', but ignorance is not an excuse. Companies have to know what the [expletive] they are putting on their shirts.
Here's the same Totenkopf being used on the front of Nazi regallia. It's not a skull that is similar to the Totenkopf, it is the friggin' Totenkopf.
Keep in mind that this isn't the first time Silverstar has been accused of using Nazi imagery in their product line. In 2002, the OC Register covered a story of Silver Star clothing using Nazi imagery and being worn in schools, even calling the clothing line 'fascist'. Huge props to WRESTLENOW of the UG for the find.


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The redshirt was removed in frantic fashion. University of Denver freshman Ryan LaPlante was on his couch March 18, watching the DU men's lacrosse team go into a third overtime at Notre Dame, when sophomore goalie Jamie Faus suffered a torn Achilles tendon in what ended as a 10-9 loss.
"I was flying to New York four hours later," LaPlante said. "I was really excited. I just want to play."
LaPlante, who made his NCAA debut March 20 against Cornell in Ithaca, N.Y., competed with Faus for DU's starting goaltending job since last fall. Coach Bill Tierney chose to go with Faus and use senior Troy Orzech, already named one of three team captains, as the backup.
Tierney and his staff wanted separation between LaPlante, a high school All-American from Fort Collins, and Faus, a New England native who helped lead DU to its historic Final Four run a year ago.
"It was a tough decision. (Faus and LaPlante) were neck and neck throughout the fall and spring," said Trevor Tierney, Bill's son and DU's goaltending coach. "But we thought if we redshirt Ryan, we really have our goalie situation figured out for quite some time. But when Jamie got injured, we had to go with what's best for the team, and that was Ryan in goal."
LaPlante is 3-3 in six consecutive starts for the Pioneers (7-5), who have lost four games by one goal, including three in overtime.
"Ryan has done a great job. He's been phenomenal," Bill Tierney said. "We have not lost a game because of Ryan being in the goal opposed to Jamie being in the goal."
LaPlante was born in Providence, R.I., and moved to Fort Collins when he was 2. In junior high, he played club lacrosse for Trevor Tierney, then the defensive coordinator for the Denver Outlaws of Major League Lacrosse. Bill was coaching at Princeton.
"The first day I worked with Ryan, I called my father, Coach T at Princeton, and said, 'You better keep an eye out for this kid,' " said Trevor, a former Princeton and Outlaws standout goalie. "Ryan has the intangibles of a great goalie. He sees the ball incredibly well. He has amazingly quick hands, and he has a very good mind-set for the game.
"Those are three things that, no matter how much you work with goalies, you can't really teach them. I've always had a lot of faith in Ryan, and he's been keeping us in some tough games. Hopefully, we can start giving him some more help as we try to make our way into the NCAAs."
DU is coming off back-to-back Eastern College Athletic Conference losses to Loyola (Md.) and Fairfield (Conn.). It will face top-seeded Loyola — ranked No. 1 nationally — in the DU-hosted ECAC semifinals May 2 at Barton Stadium. But first DU plays No. 4 Duke at Sports Authority Field at Mile High on Friday. If the Pioneers don't upset Duke, they will have to win the league tournament to gain an NCAA Tournament bid.
"We're one lucky bounce away from getting that unlucky bounce," LaPlante said. "That's what we've been talking about the last couple days, since the Fairfield loss. We'll get one soon."
Friday's doubleheader in the Mile High Classic begins with defending NCAA champion Virginia playing Penn. The No. 6 Cavaliers eliminated DU in last May's national semifinals in Baltimore.
"Huge stage, especially with Virginia and Penn playing right before us," LaPlante said. "All the guys are going to be really pumped up."
Bill Tierney doesn't expect to redshirt LaPlante or Faus next season.
"They're going to have to fight it out," he said.
Mike Chambers: 303-954-1357 or email@example.com


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Overland Golf Course
- Highway 10 East, Big Timber, MT 59011
- (406) 932-4297
|9 total holes at facility
|Green fees - $16 to $24 (estimate)
|Designed by Max Mueller
|Built in 1977
|Blue Grass
|Driving Range: Yes
|Municipal golf course
Overland Golf Course is a 9-hole regulation length golf course in Big Timber, Montana. This layout provides for a fun golf experience for golfers of all skill levels. More information about Overland Golf Course will be coming soon. Online tee times may be available at Overland Golf Course or at nearby golf courses, often at a substantial discount from the going green fees rate.
|Course Rating
|Back Tees
|Course Superintendent: Tim Hills
|Manager: Gary Mosness
Although the information is typically reliable, sometimes there may be mistakes. If you stumble upon anything that should be updated, please fill this out.
Please login to add your review.


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Trait variances among genotype groups at a locus are expected to differ in the presence of an interaction between this locus and another locus or environment. A simple maximum test on variance heterogeneity can thus be used to identify potentially interacting single nucleotide polymorphisms (SNPs).
We propose a multiple contrast test for variance heterogeneity that compares the mean of Levene residuals for each genotype group with their average as an alternative to a global Levene test. We applied this test to a Bogalusa Heart Study dataset to screen for potentially interacting SNPs across the whole genome that influence a number of quantitative traits. A user-friendly implementation of this method is available in the R statistical software package multcomp.
We show that the proposed multiple contrast test of model-specific variance heterogeneity can be used to test for potential interactions between SNPs and unknown alleles, loci or covariates and provide valuable additional information compared with traditional tests. Although the test is statistically valid for severely unbalanced designs, care is needed in interpreting the results at loci with low allele frequencies.
Keywords:Genetic association study; Quantitative traits; Interaction; Variance heterogeneity
Author's summary
Interactions among alleles at variant sites in the genome or between alleles and the environment likely play an important role in determining complex traits such as blood pressure. However, sets of interacting loci are difficult to identify due to the large number of potential interactions that need to be tested. One approach that circumvents this difficulty is to identify loci that appear to take part in an interaction although their partners with which they interact are unknown. A SNP locus containing an allele that interacts with other alleles or the environment can be identified by the existence of a statistically significant difference in the variance of quantitative trait values among individuals who possess zero, one or two alleles at the locus. We describe an extension of Levene's test, which was proposed to test variance heterogeneity. This new test has the advantage of providing information regarding the effect of specific alleles on variance heterogeneity, which can lead to formulating concrete, biologically relevant hypotheses about interacting alleles rather than just loci while controlling for type I error rate.
Statistical association between a biallelic marker and a quantitative trait is usually tested using either a two degree of freedom F-test in the one-way analysis of variance (ANOVA) [1], or a one degree of freedom F-test in a linear regression [2]. These approaches compare the means of quantitative trait values at genotype categories associated with a SNP locus (i.e., homozygous for major allele, heterozygous and homozygous for minor allele). While ANOVA is sensitive to any global heterogeneity, linear regression test is sensitive to the presence of an additive mode of inheritance. Less attention has been given to comparing the variances in the quantitative trait values associated with different genotype categories. Recently, [3] proposed using a standard Levene test [4] to identify variance heterogeneity due to potential interaction between a given locus and another allele at the same locus, alleles at different loci or the environment. They compared three global tests, namely the Bartlett-test, a rank modification of Bartlett test and Levene test particularly for non-normal distributed variables. Differences among the variances of quantitative trait values at each genotype category (denoted with j=0,1,2 interacting alleles) may reflect an interaction [5]. In contrast to approaches that explicitly test specific gene-gene, e.g. by Bayesian partition methods [6] or gene-environment interactions, e.g. by multiple regression methods [7], methods that assess variance heterogeneity can be used to uncover loci that are not previously known to interact.
Levene test [8] tests a global null hypothesis against the alternative that a difference exists between any pair of variances: . The test statistic consists of a quadratic form
(with J=3) using the robust Levene residuals
[8] with nj quantitative trait observations Yij per genotype j. The is F-distributed with df1=Jand df2=N− J.
This test is known to be relatively robust when data are not normally distributed. However, the main disadvantage of Levene's test is that it can only be used to determine whether the group-specific variances differ among each other. In order to obtain a biologically or clinically relevant interpretation of the results, it is often valuable to additionally determine which pairs of genotype categories in particular exhibit statistically significant variance heterogeneity.
To this end, [3] considered using three two-sample df−1 tests for the three comparisons vs. vs. , and vs. , where denotes the variance estimator for the pooled groups jj″. However, these multiple tests do not control for the family-wise type I error rate α.
In this paper, we propose a Levene-type multiple contrast test, a novel approach comprised of a global test on variance heterogeneity as well as the three specific tests on pairwise variance heterogeneity using a maximum test of linear forms. We apply this test in a genome-wide fashion using a Bogalusa Heart Study dataset [9].
A Levene-type multiple contrast test
For the Levene-type transformed variable Zijand the factor genotype with the levels j=0,1,2 the following contrast test for the one-way layout is used:
where S is the root of the common mean square error estimate of the linear model on the transformed data Zji (absolute Levene residuals). Contrast coefficients ckjare used for the k=3 comparisons between the means of Levene residuals for each genotype with the average of the means. These comparisons coding for vs. vs. , and vs. [10], are formulated in the 3×3 contrast matrix:
A priori it is unknown which elementary test is mostly under the alternative. Therefore, the maximum of the test statistics is used, implying a family-wise type-I-error rate αfor all of the three comparisons.
Under the approximate assumption of multivariate normal distributed errors with a homogeneous global variance of the transformed variable Zij, the vector (Tj)″ follows jointly a tri-variate t-distribution with ν= degrees of freedom and a correlation matrix R=(ρkk″) given by its elements
Under the above assumptions the correlations ρkk″depend only on the contrast coefficients ckjand the sample sizes nj. This approach controls the familywise error rate αand reveals a reasonable power for unbalanced designs as long as the above assumptions hold true. It provides a global decision whenever any of the contrasts is under the alternative and additionally the elementary decisions by multiplicity-adjusted p-values for the three specific comparisons. Although simultaneous confidence intervals for both differences and ratios to the average are available as well [11], they will not be recommended since a genetic interpretation for the transformed variable Zji is difficult. Recently, simultaneous confidence intervals for the pairwise ratios of variances were proposed using a maximum test on jackknifed [12]. This approach would provide an alternative when modified for arbitrarily unbalanced designs.
The question arises whether the quadratic form of the Levene test or the maximum contrast version of linear forms is more powerful. A general answer will not be available. For the comparison of normally distributed means, the least favorable configuration approach for reveals higher power for the maximum of linear contrasts relative to the quadratic form of the F-test of the one-way analysis of variance [13]. Alternatively, a multiple contrast test based on pairwise comparisons of the genotype-specific variances MCTPairs can be used by means of the following 3×3 contrast matrix:
Results and discussion
Simulation Study
To validate the type-I-error control and compare the power between the multiple contrast test on the Levene scores and the Levene test, a small simulation study was conducted. Observations are sampled from a standard normal distribution for the three genotype groups. Overall sample size N is varied from 25 to 100, allocating the observations under assumption of Hardy-Weinberg equilibrium with allele frequencies p for the recessive allele of 0.5 and 0.75. To generate differences in variances, the variance is increased with the number of dominant alleles by a value of δ for an additive mode of inheritance (σ0=1,σ1=1 + δ,σ2=1 + 2δ). For a recessive and dominant model, the value of δcorresponding to the intermediate genotype is changed to 0 or 2 δ, respectively. For each parameter setting 10,000 simulation replications are performed. In Table 1 for the three approaches both control of type-I-error and comparable powers from a global test perspective can be concluded for the dominant mode of inheritance. However, the new MCTPairsand MCTAveapproaches allows elementary decisions additionally. The related simulations for the additive and recessive modes are presented in the Appendix.
Table 1. Size and power comparison of the Levene test and two contrast alternatives given an dominant mode of inheritance
Evaluation of a real data example
We evaluated the utility of the proposed test using data from Bogalusa Heart Study (BHS). The longitudinal study included genotype information on 525 unrelated individuals of European descent at 545,821 SNPs [12]. Twelve clinically-relevant quantitative traits were also measured for each study participant. We applied the multiple contrast test to each SNP throughout the genome. A number of SNP loci with a p-value smaller than <10−8were identified for several quantitative traits whereas the number of SNPs with p-values below this threshold varied for different quantitative traits. For example, 23 SNP loci yielded p-values lower than that threshold when considering heart rate, while only 5 SNPs reached similar significance in the analysis involving body mass index. A thorough examination of the results showed that several significant tests occurred when the risk allele homozygote genotype group contained only a handful, i.e. 1,2,3, data points. Although the approach described in this paper is statistically valid in these situations, we selected only tests in which each genotype group contained at least one percent of all data points for further study. In the following text, we showcase two instances of variance heterogeneity in greater detail: rs3760124 and waist circumference, as well as rs12607553 and diastolic blood pressure; see the related box-plots in Figure 1.
Figure 1. Boxplots including raw data for two selected SNPs and phenotypes of the Bogalusa Heart Study.
The boxplots show relatively symmetric distributions of quantitative trait values in all genotype groups, thus ruling out the presence of outliers or extremely skewed distributions of trait values as sources of the observed variance heterogeneity. Furthermore, all three genotype categories contain a relatively large number of observed trait values resulting in reliable variance estimates.
It can be seen from Table 2 that our proposed test (labeled as MCTAve) yielded a result with greater statistical significance compared with the Levene global test. More importantly however, it allowed us to interpret the effect of the SNP alleles on variance heterogeneity. When we considered waist circumference, we found the variance heterogeneity to be most significant between the risk allele homozygous genotype group (), and the pooled variance for the two remaining genotype groups associated with the presence of at least one non-risk allele (). In addition, we can see that the variance associated with the risk allele homozygotes is significantly higher in this example. Conversely, in the second example involving diastolic blood pressure, the variance in the heterozygotes was significantly higher compared to homozygotes . Such insights may prove to be valuable in forming hypotheses for further research, and can be obtained with the Levene-type multiple contrast test that we propose here. Furthermore, pairwise comparisons (labeled as MCTPairs) can also be performed (see Table 2). From the genome-wise analysis of the endpoint waist circumference the quantile-quantile plot and the Manhattan plot are presented in Figure 2 whereas SNPs with 5 or more individuals who are homozygous for the minor allele were considered. We see the expected inflationary behavior on a genome-wise level and the relatedness of the SNPs within the blocks. But only one SNP reveals is significant interaction on a global Bonferroni level.
Table 2. P values for original and multiple contrast Levene-type tests
Figure 2. QQ- and Manhattan-plot for the phenotype waist circumference in the Bogalusa Heart Study.
An example R code for testing variance heterogeneity at a single SNP is provided in the Additional files 1 and 2. The multiplicity-adjusted p-values can be estimated by means of the R package multcomp [14]. Alternatively, a SAS procedure GLIMMIX can be used for a resampling based estimation of multiplicity-adjusted p-values [15].
Additional file 1. The R code.
Format: PDF Size: 8KB Download file
This file can be viewed with: Adobe Acrobat Reader
Additional file 2. The data settg.rdacontains the subject-specific diastolic blood pressure data and the related genotype levels of the SNP rs12607553.
Format: RDA Size: 1KB Download file
The important issue of missing heritability, which refers to the fact that common SNPs identified by genome-wide association studies as associated with a disease collectively explain only a small portion of the prevalence of this disease, may be due, in part, to the presence of unknown interactions among alleles at various SNP loci or environment, that affect the disease. The identification of such interactions is difficult, primarily because of the large number of potentially interacting pairs, trios, etc. of alleles and environmental variables that need to be tested. A feasible alternative, as suggested by [5], is to test individual loci for the evidence of their involvement in an interaction with other alleles, loci or covariates. The idea of assessing variance heterogeneity between three genotype groups at a particular SNP locus as evidence of a potential interaction is appealing for its simplicity. The Levene-type maximum contrast test proposed in this paper allows one to not only test for global variance heterogeneity, but also perform groupwise test that allows one to elucidate the effect of the individual alleles on quantitative trait variance. While this is an advantage over the standard Levene test, the price to pay is increased computing time. However, we were able to perform a genome-wide analysis of variance heterogeneity involving >500 individuals in a matter of minutes on a laptop computer. Parallelization can also be used to substantially decrease computation time requirements. R code implementing this test is available as part of the multcomp package.
Even the analysis of real data example illustrates the low specificity of the identified potential interactions. Care needs to be exercised in interpreting the results of this test in cases of low frequency variants or missing trait data, when one or more of the genotype groups contains an extremely small number of observed trait values. The issues surrounding the sensitivity and specificity of this approach in these potentially common cases is an area that needs further work.
The simulation results for the additive and recessive mode of inheritance are presented in Tables 3 and 4.
Authors' contributions
LAH and DG derived the method. LAH and OL developed the software. OL performed the GWA analysis. LAH, OL and DG wrote the manuscript. All authors read and approved the final manuscript.
We appreciate the two anonymous reviewers for their insightful and constructive comment. The work for the first author was partly supported by the German Science Foundation grand DfG-HO1687.
Liu YZ, Pei YF, Guo YF, Wang L, Liu XG, Yan H, Xiong DH, Zhang YP, Levy S, Li J, Haddock CK, Papasian CJ, Xu Q, Ma JZ, Payne TJ, Recker RR, Li MD, Deng HW: Genome-wide association analyses suggested a novel mechanism for smoking behavior regulated by IL15.
Zhao JH, Li MY, Bradfield JP, Zhang HT, Mentch FD, Wang K, Sleiman PM, Kim CE, Glessner JT, Hou CP, Keating BJ, Thomas KA, Garris ML, Deliard S, Frackelton EC, Otieno FG, Chiavacci RM, Berkowitz RI, Hakonarson H, Grant SFA: The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.
Struchalin MV, Dehghan A, Witteman JCM, van Duijn, Aulchenko YS: Variance heterogeneity analysis for detection of potentially interacting genetic loci: method and its limitations.
Levene H: Robust tests for equality of variances. In Contributions to Probability and Statistics. Edited by Olkin I. Palo Alto, CA: Stanford University Press; 1960:278-292.
Pare G, Cook NR, Ridker PM, Chasman DI: On the use of variance per genotype as a tool to identify quantitative trait interaction effects: A report from the women's genome health study.
Zhang Y, Jiang B, Zhu J, Liu JS: Bayesian models for detecting epistatic interactions from genetic data.
Erhardt V, Bogdan M, Czado C: Locating multiple interacting quantitative trait loci with the zero-inflated generalized poisson regression.
Gastwirth JL, Gel YR, Miao WW: The impact of levene's test of equality of variances on statistical theory and practice.
Smith EN, Chen W, Kahonen M, et al.: Longitudinal Genome-Wide Association of Cardiovascular Disease Risk Factors in the Bogalusa Heart Study.
Hasler M, Hothorn LA: Multiple Contrast Tests in the Presence of Heteroscedasticity.
Djira GD, Hothorn LA: Detecting Relative Changes in Multiple Comparisons with an Overall Mean.
Rublik F: A note on simultaneous confidence intervals for ratio of variances.
Hayter AJ, Liu W: The Power Function of the Studentised Range Test.
Bretz F, Hothorn T, Westfall P: On multiple comparisons in R.
SAS Institute Inc. 2008: SAS/STAT® 9.2, User′s Guide. Cary NC: SAS Institute Inc.;


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Open Daily 10:00 - 17:00 Call: 0191 515 5555
Open Daily 10:00 - 17:00 Call: 0191 515 5555
To search for specific research from the University of Sunderland follow the link.
For a full list of publications by staff at the University of Sunderland follow the link below
The Reading Room contains books, exhibition catalogues, PhD and Master of Philosophy dissertations and the archive of the Institute for International Research in Glass. For information on accessing the Reading Room follow the link below
Glass Artist
I am an Israeli artist based in the UK working primarily in kiln cast glass.
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I have worked at National Glass Centre since finishing my degree in 2005.
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I am Head of Enterprise, Commissioning and the Studio at National Glass Centre at the University of Sunderland, England and am a member of the Senior Management Team.
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My practice is interdisciplinary combining drawing, sculpture and film.
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Sara Jo Harrison joined National Glass Centre in 2012 to support the Centre's marketing and Communications strategy.
My work uses a range of media which acknowledges the interface between both traditional practice and new media.
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The third annual installment of Remy Bumppo Theatre Company's thinkTank combines hip-hop, spoken word and theater aesthetics to examine the mass media's role in perpetuating cultural norms surrounding race and gender. As Americans we are at a crucial and historic period in our country. With the election of the first African American President, political commentators have espoused the belief that we are now living in a "post-racial world" and that racism has been rooted out of our culture, while others have insisted that there is still much work to be done.
Hip hop theater artist Usman Ally, and award winning slam poets Kelly Zen-Yie Tsai and Idris Goodman expose the way that television sitcoms, news networks and commercials influence public perception regarding race and ethnicity, and how the media can either be a tool for deepening or dismantling race, class and gender lines in America.
The production is directed by Remy Bumppo Artistic Associate Nick Sandys and produced by Remy Bumppo Artistic Associate Shawn Douglass.
Please note: This reading contains sexually explicit language.
Remy Bumppo's thinkTank features short dramatic works with a focus on provoking timely conversation about a social, political or economic issue in which Chicago citizens have a stake. Each night, a post-show discussion follows, led by speakers from the community representing various viewpoints on thinkTank's theme. Past topics include immigration (2007) and national security (2008).
Also recorded in conjunction with this event:
Thursday, March 12 - E. Patrick Johnson
Friday, March 13 - David Stovall
Saturday, March 14 - Alka Nayyar and Samuel Park
Sunday, March 15 - Jacqueline Stewart
Recorded Thursday, March 12, 2009 at The Greenhouse Theater.


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There are a lot of things we would do for our hypothetical children to stop them from hypothetically having a bad educational experience, but we don't know yet if rhinoplasty is hypothetically one of those things. But one New York couple decided it was the best way to prevent their teenage daughter from being teased and bullied at school.
Last night, ABC's Nightline featured Nicolette Taylor, a 13-year-old Long Island girl faced with self-image corrupting levels of teasing at school. Taylor's mother Maria described her as an active girl who was always outgoing. She even modeled as a child. But after breaking her nose twice, she developed what she called "crooked bump" that made her the target of taunting in person — and online.
"They went on Facebook, and they started posting, 'Hey big nose,'" said Maria Taylor, Nicolette's mother, in an interview with "Nightline" correspondent JuJu Chang. "It happened probably about five times that week. … I came in when she was on the phone with the boy, and I took the phone from her, and I said, 'Listen, you need to take them off Facebook.' I was crazy, crazy."
Crazy enough that she called a local plastic surgeon for a consultation and, when she found out that bullying is "quite frequently" a factor in the decision to have a procedure done, signed Nicolette up to have her nose straightened out.
While child psychologists caution that being physically and emotionally mature enough for a procedure like this is important, Nicolette's result overwhelmed both her and her family with joy.
Since her surgery, Nicolette has started school and has even made the cheerleading team. She said she knew bullying might happen again, but now that she felt better about her appearance, she didn't care.
What do you think. Is the confidence to stand up for yourself worth a drastic elective surgery?
[ABC News via The Huffington Post]


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Management of Ureteral Injuries
Jun 2012 – by L. Copeland, MD
A 35-year-old patient presents with the complaint of new onset left flank pain on postoperative day #6 following a difficult hysterectomy and bilateral adnexectomy for severe endometriosis, related to a didelphic uterus. You are asked to assess and manage the problem.
Postoperative urinary tract injuries are one of the many risk factors associated with pelvic surgery. It is estimated that the risk of injury to the urinary tract is about 1% and many of these injuries are occult at the time of surgery. Obviously, any recognized injury at the time of surgery should be repaired at that time. Occult injuries of either the bladder or ureters may subsequently cause an obstructive uropathy or leakage of urine outside of the urinary collection system. In the postoperative interval the complaint of new onset flank pain should raise the question of possible obstruction and diagnostic interventions should evaluate the patient for hydronephrosis and hydroureter. Ureteral injury resulting in extravasation of urine from the collecting system will often present with an ileus and possible low grade fever. The serum creatinine may or may not be minimally elevated.
While ureteral injuries may occur in an anatomically normal surgical field, the most common risk factor associated with ureteral injuries is the presence of anatomic distortion. The etiology of the anatomic distortion can be varied and multiple. Common causes of anatomical variances include embryologic anomalies (e.g. double ureters), prior surgery (e.g. C-sections, renal transplants), tumors, (both benign - e.g. fibroids; and especially infiltrative malignant tumors), severe endometriosis, and severe acute or chronic inflammatory disease (including fibrosis from prior surgery or radiation).
Preventive strategies are worthy of consideration. Preoperative imaging may help define unsuspected anatomical distortion. During the surgical procedure, optimal exposure of adjacent anatomical structures should be maximized. The ureter is most reliably identified at the pelvic brim. The most common steps to identify the ureter at this location are as follows: enter the retroperitoneum lateral to the infundibulopelvic ligament; identify the iliopsoas muscle; identify the external iliac artery medial to the muscle; move superior along the artery to the level of the common iliac bifurcation; the ureter should cross the bifurcation of the common iliac artery and then run along the lateral edge of the medial leaf of the broad ligament. The placement of ureteral stents preoperatively may be of help for some surgeons, however it has also been suggested that they may increase the risk of injury to the ureter. In general, ureteral stents are not required to aid in the identification of normal anatomy. If possible, the direct visualization of the urinary tract structures throughout the surgical procedure is the best method to avoid a urinary tract fistula.
In the patient presenting above, one should review the history, including the details of the surgery and perform a focused pelvic examination. Imaging, including an intravenous pyelogram or CT scan, pelvic or renal ultrasound, may help identify the nature of problem. Also a well-performed retrograde pyelogram can provide information regarding the status of the ureters. The retrograde pyleogram carries less risk of damage to the kidneys compared to the use of intravenous contrast. Cystoscopy or cystograms may also be useful to evaluate for bladder injuries.
If either a ureteral blockage or a ureteral defect is found, the first consideration is to place a ureteral stent is using the retrograde approach. If this fails, then placement of a percutaneous nephrostomy, with subsequent antegrade stent placement is advised. Of course, if conservative management is neither possible nor successful, then surgical intervention may be necessary to resolve the defect.
Ureteral defects may require reimplantation of the ureter (ureteroneocystotomy), segmental resection and anastomosis and in rare occasions the use of a segment of small bowel in the performance of an ureteroileoneocystotomy.
1. Forsgen C, Altman D. Risk of pelvic organ fistula in patients undergoing hysterectomy. Curr Opin Obstet Gynecol 2010, 22: 404.
3. Copeland LJ, Hatch KD, Fowler JM. Urinary tract injury and fistula. Textbook of Gynecology, W.B. Saunders, Philadelphia PA, 2000 p. 1093.
5. Gallup DG, Nolan TE. Prevention, diagnosis and management of ureteral injuries. The Female Patient 1994, 19:93.


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YIELD: 8-12 servings
Ingredients4 cucumbers
2 small onions
1 T. celery seed
1 T. dill weed
1 C. sugar
1 C. cider vinegar
PreparationIn a sauce pan heat the sugar, vinegar, celery seed and dill weed. Stir until sugar
dessolves. Remove from heat.
Pear and cut cucumbers thin. Cut onions in slices. Put sugar, vinegar water into a glass covered dish. Add the onions and cucumbers. Refrigerate and keep cold.
Serve drained cucumbers and onions in a dish. Keep the sugar vinegar solution for additional onions and cucumbers.


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Fisher Island ,an exclusive development, is located adjacent to Government Cut, just south of Miami Beach. (Image LK070156-0239_a.psb) This gigapan was photographed from a vantage point on Virginia Key. The buildings in the foreground are 1/2 mile from the camera location and the high-rise buildings are at a distance...
Beautiful, picturesque, Pulicat Lake is the second largest brackish water lagoon in India Chilka lake in Orissa, spread over the two states of Andhra Pradesh and Tamil Nadu, adjacent to the Bay of Bengal. It extends over 600 sq km in Andhra Pradesh and is a bird watchers paradise. Migratory water birds and other birds ...
Nallapattu Bird Sanctuary is about 20Kms from Sulurupetta on the National Highway#5.(100Kms from CHENNAI).Driving north from Sullurpet on NH 5 about 10Kms you would reach DORAVARICHATTRAM, a village 1 Km from the sanctuary. Turn right and drive to reach the sanctuary The bird sanctuary is the breeding ground for birds ...
Fisher Hall is located on The Ohio State University Fisher College of Business campus and named in honor of Max M. Fisher.
Fisher Body plant 21 was built in 1919 at the corner of Hastings and Piquette Avenues in Detroit. It is 581 feet long and 200 feet wide and has 6 stories. The plant built bodies for Cadillacs and Buicks until 1974.
This is a head shot of the ant Eutetramorium mocquerysi which is found in Madagascar and is notable for having wingless queens that are indistinguishable from workers. This image is magnified 400x and is composed of 175 individual pictures. The ant was given to us to image by Brian Fisher (www.calacademy.o ...
This is another ant given to us to image by Brian Fisher (www.calacademy.org/science/heroes/bfisher /) an entomologist at the California Academy of Sciences. This is a frontal view, straight on of its head. The ant is magnified 200x using a scanning electron microscope. This Gigapan is part of the NanoGigaP...
Fairway to 1st Green at Emerald Hills Golf Course near Forien and many Louisiana and across from Hodges Gardens State Park. 4th Green is also visible on the right side of the photo.
17th Green at Emerald Hills Golf Course near Forien and many Louisiana and across from Hodges Gardens State Park


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WELCOME... thanks for visiting SPORT Clinic Physical Therapy!
"As a teacher in the Menomonee Falls High School for 38 years, learning has always been important to me. In the mid-80's I was referred to the SPORT Clinic after foot surgery. The one-on-one instruction to strengthen my foot and leg muscles resulted in a quick recovery with little time missed from work. In 1992 my orthopedist did some work on my knee and again recommended therapy, but also told me my knee would need additional surgery in five to seven years.
My physical therapist taught me leg exercises that I still use today and I have not had any additional surgery on my left knee. When I hurt my shoulder and neck in 2008 my primary care doctor recommended therapy and I said I wanted to do it at the SPORT Clinic. John and Dan taught me exercises to keep my shoulders and neck loose that I could do at home and work. They also taught me how to lie so it was possible to sleep through the night. I have seen SPORT Clinic grow from its beginning to now with two clinics and a very friendly and caring staff. I highly recommend SPORT Clinic for physical therapy."
Sandy Swanson
In February, SPORT Clinic opened a new location on Hwy 60 in Cedarburg, just east of five corners. Call us today at 414.351.5794 to set up an appointment at any of our convenient locations:
Whether you are recovering from an injury or surgery, wish to unravel the mystery of nagging aches or pains, or want to become more competitive in your sport of choice, SPORT Clinic can help! Through prevention and rehabilitation we help our patients retain or regain flexibility and strength. We are committed to providing accessible care and programs that can be easily maintained for a lifetime of health.


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A special day for critters of the two-legged type at Boo at the Zoo
What: Boo at the Zoo
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The seca 676 is very versatile, stable, functional, and mobile thanks to its large platform and robust handrail. People can be weighed sitting in a wheelchair or on a chair, while the handrail provides valuable support for people who are fragile or can only walk with great difficulty. Its high capacity makes the seca 676 ideal for weighing very heavy persons. Concomitantly, the scale can be folded together after use in no time at all to save space. The sturdy locking device between rail and platform ensures that the seca 676 stands safely even when folded together. The handrail also serves as handle when the scale is folded together, allowing the it to be moved around or stowed away effortlessly and quickly on its smooth running transport casters.
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If you think classic RPGs are a thing of the past, the Finnish four-man development studio known as Almost Human can certainly convince you otherwise. After taking pre-orders and then releasing its old school dungeon crawling RPG Legend of Grimrock last Wednesday, the developers told Gamasutra that the game's development costs have already been covered "many times over."
For those that don't know, here's a description of what the game is all about:
Legend of Grimrock is a dungeon crawling role playing game with an oldschool heart but a modern execution. A group of prisoners are sentenced to certain death by exiling them to the secluded Mount Grimrock for vile crimes they may or may not have committed. Unbeknownst to their captivators, the mountain is riddled with ancient tunnels, dungeons and tombs built by crumbled civilizations long perished now. If they ever wish to see daylight again and reclaim their freedom the ragtag group of prisoners must form a team and descend through the mountain, level by level.
The game brings back the oldschool challenge with highly tactical real-time combat and grid-based movement, devious hidden switches and secrets as well as deadly traps and horrible monsters. Legend of Grimrock puts an emphasis on puzzles and exploration and the wits and perception of the player are more important tools than even the sharpest of swords could be. And if you are a hardened dungeon crawling veteran and you crave an extra challenge, you can arm yourself with a stack of grid paper and turn on the Oldschool Mode which disables the luxury of the automap! Are you ready to venture forth and unravel the mysteries of Mount Grimrock?
Thanks to the quick sales, Almost Human has stated that the future for the independent developer "seems pretty secure", and that Mac and iOS release for the game is currently planned. Of course, success on those platforms as well might just mean that we'll eventually see the Legend of Grimrock continue in sequel form, but for now, you can see what all of the fuss is about by visiting the game's official website.


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Flagler County deputies say they nabbed a Palm Coast burglar after they caught him walking around the neighborhood carrying his burglary tools in a sweater.
Frank Debisceglie, 28, was arrested on Wednesday in connection to a home burglary on Warren Place.
Deputies said they spotted Debisceglie walking in the area of Wynnfield Drive carrying a sweater under his arm and stopping and staring at several homes. When deputies approached Debisceglie, they asked what he had wrapped in his sweater, to which he replied "work tools."
When deputies searched Debisceglie, they found a black beanie cap with eye holes cut out, a screwdriver, crowbar and gray gloves.
He was taken to Flagler County jail on charges of possession of burglary tools, burglary and violation of probation.
"The Safe Neighborhood Unit and our detectives did an excellent job in putting this man behind bars. They identified an area where a burglary had occurred and then moved in and concentrated their patrol efforts in that area which ultimately lead to the arrest of this individual," said Sheriff James L. Manfre in a release.
Debisceglie is being held on no bond.


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Build up your eveningwear staples with this classic McQ tuxedo jacket. The curved lapel is a nod to spring's softly structured lines whilst the importance of the cut is reflected in the sharp shoulders and tapered waist. An extremely wearable piece which fits beautifully. Shown here with a McQ scarf, an Alexander Wang vest, Chloé shoes and bag and See by Chloé shorts.
Black stretch wool tuxedo jacket with rubberized trim. McQ jacket has curved lapels, a pocket on each hip and a single button fastening in front. 74% virgin wool, 22% polyester,2% elastane, 2% nylon. Dry clean. Italian sizing.
Product code: 29910 - Need help? Contact us


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Cost-effectiveness of problem-solving treatment in comparison with usual care for primary care patients with mental health problems: a randomized trial
Author affiliations
1 Department of Health Sciences and EMGO Institute for Health and Care Research, Faculty of Earth and Life Sciences, VU University Amsterdam, Amsterdam, The Netherlands
2 Department of General Practice and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
3 Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
4 Department of Epidemiology & Biostatistics and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
Citation and License
BMC Family Practice 2012, 13:98 doi:10.1186/1471-2296-13-98Published: 10 October 2012
Mental health problems are common and are associated with increased disability and health care costs. Problem-Solving Treatment (PST) delivered to these patients by nurses in primary care might be efficient. The aim of this study was to evaluate the cost-effectiveness of PST by mental health nurses compared with usual care (UC) by the general practitioner for primary care patients with mental health problems.
An economic evaluation from a societal perspective was performed alongside a randomized clinical trial. Patients with a positive General Health Questionnaire score (score ≥ 4) and who visited their general practitioner at least three times during the past 6 months were eligible. Outcome measures were improvement on the Hospital Anxiety and Depression Scale and QALYs based on the EQ-5D. Resource use was measured using a validated questionnaire. Missing cost and effect data were imputed using multiple imputation techniques. Bootstrapping was used to analyze costs and cost-effectiveness of PST compared with UC.
There were no statistically significant differences in clinical outcomes at 9 months. Mean total costs were €4795 in the PST group and €6857 in the UC group. Costs were not statistically significantly different between the two groups (95% CI -4698;359). The cost-effectiveness analysis showed that PST was cost-effective in comparison with UC. Sensitivity analyses confirmed these findings.
PST delivered by nurses seems cost-effective in comparison with UC. However, these results should be interpreted with caution, since the difference in total costs was mainly caused by 3 outliers with extremely high indirect costs in the UC group.
Trial registration
Nederlands Trial Register ISRCTN51021015


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Bols De Drie Papegaaien (the three parrots) is part of Lucas Bols' 'VOC Collection'. A spicy genever with notes of liquorice and cinnamon with underlying wood and malt notes.
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VLC On Demand
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Basic Product Labeling
Basics of Polymers - Part 1
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Defoamer Theory, Application & Selection in Coatings
EPA Paint and Allied Products/Chemical Manufacturing Area Source
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This VLC will provide information for paint and coatings companies on the scope, applicability, and indoor air quality requirements of emerging green building standards and codes affecting the industry.


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Bank2PDF 18.104.22.168
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Tipard Mac iPhone Data Recovery 8.0.16
Tipard iPhone Data Recovery for Mac allows you to retrieve deleted photos, text massages, videos, contacts and more file from iPhone/iPad/iPod directly for Mac. Besides, it can also recover lost data from iTunes and iCloud backup on Mac. It supports all portable iOS devices including iPhone 6S/6S Plus, iPhone 6/6 Plus, iPhone 5s/5c, iPad pro, iPad mini 4/3/2, iPod 5, iPad Air and iPod touch, etc. Key Functions: 1. Recover photos, text massages, contacts from iPhone/iPad/iPod IPhone Data Recovery for Mac can help you recover lost data such as photos, text massages, contacts, videos, music, songs and more data from iPhone 6S/6S Plus, iPhone 6/6 Plus, iPhone 5s/5c, iPad pro, iPad mini 4/3/2, iPod 5, iPad Air and iPod touch and other iPhone, iPad and iPod devices. 2. Recover data on Mac from iTunes backup files As a best iTunes backup extractor, iPhone Data Recovery Mac can help you recover deleted/lost photos, text massages, contacts, etc from iTunes. Thus, you can get your files back to your phones. ...
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MeshMagic 3D Modeling Software Free 1.05
MeshMagic is an excellent 3D modeling program for viewing and editing STL files. The interface is intuitive and allows users to rotate and scale existing meshes. With MeshMagic you can select entire objects, surfaces triangles, lines, or points. Use MeshMagic 3D to transform a 2D outline into A 3D object.
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Dreamland Inc 1.9
Dreamland Inc. - A corporation that studies technology view and change dreams. You - a volunteer who decided to test this tehologiyu myself. In the dream, you must pass all three tests, and all you need to cross the blocks from the starting point at the transition point. It's not as easy as it seems. Yes, and you can bring in your test items, whether flower meadows or nightmares.
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AtoZ Clipboard Extension 6.04
Free Clipboard Extension - AtoZ Clipboard is a free utility which allows you to copy up to 25 times before pasting. (Unlike the Windows clipboard which only allows you to copy once.) The small clipboard window floats above your work and you can see the first few words of each clip to remind you what they are. When you put the mouse over a clip, you see more of it in an optional pop up preview window.
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Tipard iPhone Data Recovery 8.0.36
Tipard iPhone Data Recovery enables you to retrieve deleted photos, massage, contacts, video and others from iPhone/iPad/iPod directly or from iTunes/iCloud backup files. It supports iPhone 6S/6S Plus, iPhone 6/6 Plus, iPhone 5s/5c, iPad pro, iPad mini 4, iPad Air and iPod touch and other iOS devices. After updating, it is compatible with windows 10. Key Functions: 1. Recover data from iPhone/iPad/iPod This iPhone Recovery enables you to recover deleted data including photos, text massages, contacts, videos and more from your iPhone 6S/6S Plus, iPhone 6/6 Plus, iPhone 5S/5C/5/4S, iPad pro, iPad mini 4, iPod Touch 5/4 and so on. 2. Recover data from iTunes backup files As a best iTunes backup extractor, iPhone Data Recovery can help you recover deleted/lost photos, text massages, contacts, videos, etc from iTunes backup files. 3. Restore iPhone data from iCloud to computer Tipard iPhone Data Recovery allows you to recover the files like photos, text massages, contacts, videos and more from iCloud ...
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FireDaemon Session 0 Viewer 1.0.3
The FireDaemon Session 0 Viewer is a Windows utility that makes switching back and forth between your logged in Windows desktop and Session 0 easy. The software product automatically enables interactive services and overcomes several limitations of the built in Windows Interactive Service Detection Service including simple switching via a System Tray applet and ability to bring applications running on Session 0 to the foreground.
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Abacre Restaurant Server 1.0
Abacre Restaurant Server is a restaurant's private cloud software. Any tablets/phones may be easily used by waitresses to place orders, by managers may view reports from any location, by accountants to create accounting transactions, by customers to view menus or order item for delivery.
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Tipard Mac Video Converter Platinum 3.8.26
Tipard Mac Video Converter Platinum is able to convert any video to MP4, MOV, AVI, M4V, WMV, FLV and others, and HD videos like D AVI, HD MPG, TS, HD WMV, HD MKV and more at high speed and without any loss on Mac. Besides, it can convert your video to 3D videos like 3D TS, 3D MKV, 3D AVI and so on. Thus, you can enjoy videos on iPhone 6S/6S Plus, iPhone 6/6 Plus, iPad pro, iPad mini 4, Samsung Galaxy Note 5, HTC ONE and more. This software also allows you to trim, crop, merge, watermark video and adjust video effect. Key functions: 1. Convert any video to MP4, MOV and more Tipard Video Converter Mac enables you to convert any video to MP4, MOV, AVI, M4V, WMV, FLV and more, and HD videos including HD TS, HD MTS, HD M2TS, HD WMV and more, as well as 3D TS, 3D MKV, 3D AVI and other 3D videos on Mac. 2. Convert video to MP3, FLAC, WAV and more With this Video Converter for Mac, you can extract audio from video file and convert it to any popular audio format, like MP3, FLAC, WAV, WMA, AAC, ALAC, AC3, etc. ...
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Security Monitor Pro 5.37
Professional Video Surveillance Software With Support For Multiple IP and USB Cameras. Security Monitor Pro is the perfect solution for complex security problems. It can monitor and record from multiple cameras simultaneously, create continuous video recordings, and view multiple cameras in a single window. Each camera can be configured individually. When motion is detected, it can send email and/or record audio / video.
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Soda PDF 8
Soda PDF 8 A Complete and Modular PDF Solution. Read PDFs, eBooks (.ePub) and comics (.cbr & .cbz) just like real books with our innovative 3D technology. Pick from our easy to use modules such as Create, Convert, Edit, Insert, Review, Forms, Secure & Sign, and OCR to make your own customized PDF software. Use Soda PDF Online Services to save, access, and manage your files in the cloud and work on your documents in your browser of choice.
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Convert EML PST 5.0
Want to convert EML PST, but not aware of the method to get it done? Yes, than you are at right place, here we provide you EML PST Converter program that taking very less time of your converts EML files to PST format, so you can view them in MS Outlook. This program gives you batch mode option to Convert EML PST that makes it possible for you to move multiple mails at once into Outlook.
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Falco Blood 6.7
Classic TDS - Shooter, top view. You are in a confined space being attacked by monsters. Advance through 12 levels using various cool weapons and reinforcement bonuses. Festive music and dynamic gameplay assure you will not get bored!
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AnyMP4 MP4 Converter for Mac 6.2.70
AnyMP4 MP4 Converter for Mac enables you to convert DVD disc/ movie to MP4. Besides, it can convert MOV, M4V, MKV, AVI, TS, MTS and other video files to MP4 on Mac with super fast converting speed and excellent quality. Meanwhile, it can convert your video to HD MP4 (*.mp4), HD H.264 (*.mp4), HD MPEG-4 (*.mp4) and more. Moreover, this software owns powerful editing functions like cropping, trimming and adding watermark. Key functions: 1. Convert DVD disc/ movie to MP4 on Mac This MP4 Converter Mac enables you to convert any DVD disc/ movie, DVD Folder and DVD ISO File to MP4 on Mac. Thus you can enjoy the output MP4 video on iPhone 6S/6S Plus, iPhone 6/6 Plus, iPad pro, iPad mini 4, Samsung Galaxy Note 5 and so on. 2. Convert TS, MOV, M4V, MKV and more to MP4 for Mac This Mac MP4 Converter enables you to convert any popular video to MP4 with super fast speed for Mac. For example, you can convert TS to MP4, MOV to MP4, M4V to MP4, WMV to MP4, MKV to MP4, AVI to MP4 and other video to MP4. It can ...
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WMI Tools 8.0
WMI Tools is a free toolkit from AdRem Software designed to access WMI information both locally and remotely. It includes views for general info, processes, services, event log, hardware, operating systems and a WMI explorer for defining and using custom WMI queries.
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Tipard PDF Converter Platinum 3.2.52
Tipard PDF Converter Platinum is able to help you convert PDF files to Word, Text, RTF, Excel, EPUB, PPTX, HTML with perfect output quality. Besides, it also offers JPEG, PNG, GIF, TIFF, BMP, TGA, PPM, JPEG 2000 and other image output formats for you to choose. This software allows you to choose your needed PDF pages. Moreover, it supports multi-languages: Slavonic, English, Turkish, Thai, Latin, Korean, Greek and more. After updating, it is highly compatible with windows 10. Key functions: 1. Convert PDF to Word and other formats This PDF to Doc enables you to convert PDF to Word, Text, RTF, Excel, EPUB, PPTX, HTML and other documents file so that you can enjoy your PDF file at any time without the help of PDF Reader. 2. Convert PDF files to JPEG, PNG With the assistance of PDF to Image, you can convert your PDF file to JPEG, PNG, GIF, TIFF, BMP, TGA, PPM, JPEG 2000 and other image output formats. You can adjust the JPEG quality, output color and resolution for the output image. 3. Support OCR t ...
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Web Calendar Pad 2015.8
Generate an HTML calendar that visitors can view, print and subscribe to with RSS. Ideal for keeping a company, school, church event calendar online. For a teacher to track and publish printable course calendars or a coach to keep a sports team schedule online. The calendar wizzard lets you use custom photos,textures and fonts. FTP is built-in and you can update web site with one click using. Attach files, and publish with iCal and RSS feeds.
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Webcam Video Capture 6.0
Capture webcams, streaming video, full screen, part of the screen and even video with sound. Seeing is believing! Use it to make people witness what you want to convey through an audio-visual medium. Demonstrate product, create presentation with your own audio narration, make voiceover tutorial, or walk through a website review.There are times when sharing exactly what you see on your screen is the quickest and clearest way to communicate.
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Clipdiary 3.7
Install our clipboard history manager and you will never lose data once copied. This clipboard manager runs on Windows startup and records everything placed in the clipboard into the database. You can always view the clipboard history, copy the item back into the memory or paste it into an application. All you have to do is press the "Ctrl D" key combination or choose the program icon in the system tray.
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1st Choice Free Clipboard Manager 6.03
The 1St Choice Clipboard manager floats on top of your current work. Whenever you cut or copy, the clip appears in one of the slots. The slot only shows the first few words of each text clip or the words "Graphic Clip" but when you move the mouse pointer over the slot, a preview window appears showing the first several lines of a text clip or a thumbnail of a graphic clip. This makes choosing the clip you want to paste very easy.
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JavaScript Framework Shield UI 1.7.13
The JavaScript Framework by Shield UI offers various JavaScript/HTML5 components for streamlined development. Each individual control in the ever-expanding product offering boasts excellent performance and high-level of customizability. All of this is backed by an industry leading 24/7 support packages. The components include 23 different Chart types, Grid view widget, TreeMap, different input widgets like an editable ComboBox, and many more.
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Use motion sensors to detect activity within a certain area. They provide convenience by turning lights on automatically when someone enters a room. They reduce lighting energy use by turning lights off soon after the last occupant has left the room.
Our Mission
The mission of The Energy Conscious is to help consumers understand their choices when it comes to energy and water saving applications available. An unwavering commitment to a superb customer service experience drives our efforts to maintain a long-term relationship with our clients while keeping homes and businesses as energy and water efficient as possible.
We only offer products that save energy and water, delivering unmatched efficiency. Many of our products will have the highest efficiency labels, including (but not limited to) Energy Star, Water Sense, and LEED (USGBC).
My Money, My Planet
Our motto, "My Money, My Planet," serves to tell our story that both people and the environment can comfortably thrive together. Every aspect of what we do is focused on saving. From your wallet, to your energy to your planet, each purchase from The Energy Conscious triggers three types of built-in savings - for your wallet, for your energy, and for your environment.
Most of our national discourse is focused on how to increase the availability of various sources of energy, as our population grows and our natural resources are finite. At The Energy Conscious, we believe that there is just as large a role for energy and water saving through efficiency. Energy and water efficiency means wasting less without sacrificing comfort�unlike conservation, which requires (sometimes painful) changes in behavior.
A 2009 study by the consulting firm McKinsey found that efforts to boost efficiency by using existing technologies could reduce American energy consumption by more than 20% by 2020. This is a whopping statistic, which reflects substantial savings to consumers and industry alike, and real progress in caring for our planet and environment.
Efficiency often comes from using new technologies that are more attuned to energy saving, like fluorescent lighting, tankless water heaters, or dual and low flush toilets. But consumers can also save energy by using existing units more productively (for example, by insulating pipes and ducts or caulking windows and doors). Either way, improving efficiency pays for itself quickly by lowering energy and water bills year after year while also promoting a clean environment.


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The lack of access to safe water and sanitation has many other serious repercussions. Children and particularly girls are denied their right to education because they are busy fetching water or are deterred by the lack of separate and decent sanitation facilities in schools. Women are forced to spend large parts of their day fetching water. Poor farmers and wage earners are less productive due to illness, and national economies suffer. Without safe water and sanitation, sustainable development is impossible.
UNICEF works in more than 90 countries around the world to improve water supplies and sanitation facilities in schools and communities, and to promote safe hygiene practices. We sponsor a wide range of activities and work with many partners, including families, communities, governments and like-minded organizations. In emergencies we provide urgent relief to communities and nations threatened by disrupted water supplies and disease. All UNICEF water and sanitation programmes are designed to contribute to the Millennium Development Goal for water and sanitation: to halve, by 2015, the proportion of people without sustainable access to safe water and basic sanitation.
Unsafe water and lack of sanitation and adequate hygiene contribute to the leading killers of children under five, including diarrhoeal diseases, pneumonia and undernutrition, and have implications for whether children - especially girls - attend school. Thus achieving Millennium Development Goal 7, and its 2015 targets of reducing by half the proportion of people without sustainable access to safe drinking water and basic sanitation, is of vital relevance for children and for improving nutrition, education and women's status. This issue of Progress for Children reports on whether the world is on course to reach MDG 7, and where efforts are falling short.


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December 08, 2011 - JT Holmes
Espen Fadnes and Goovinn together came up with the idea to place he viewer in the mind of the wingsuit flyer. They actually listen to his thought process in flight by managing to capture his voice in flight through sensors placed on his voice box/trachea or something. Pretty interesting stuff. Well done E-fad.


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Lehigh vs. Penn State
March 9, 2013
|Dante Fantoni
|(3, 2)
|Dan Taylor
|(2, 3)
|Patrick Corbett
|(3, 0)
|David Dimaria
|(0, 2)
|Jimmy Cahill
|(0, 1)
|Baxter Lanius
|(0, 1)
|Kyle Stiefel
|(1, 0)
|Alan Henderson
|(1, 0)
|Cody Ferraro
|(1, 0)
|Alex Drake
|(1, 0)
|Matt Poillon
|11 (0.524)
|Current Record
|go to Lehigh page
|Tj Sanders
|(5, 1)
|Shane Sturgis
|(2, 1)
|Jack Forster
|(2, 1)
|Danny Henneghan
|(0, 2)
|Matt Sexton
|(0, 2)
|Erik Myers
|(1, 0)
|Nick Dolik
|(0, 1)
|Austin Kaut
|7 (0.368)
|Current Record
|Penn State
|go to Penn State page
|The Game Story:
| CHESTER, Pa. - No. 13 Penn State men's lacrosse dug itself a four-goal halftime deficit, went on a big 8-2 run, but eventually lost to No. 19 Lehigh, 11-9, on Saturday night in front of 5,212 at PPL Park. TJ Sanders (Orillia, Ont.) scored five goals during the 8-2 spurt to take a 9-7 lead. Lehigh finished the game on a 5-0 run to win their second straight contest over the Nittany Lions.
Down 5-1 after two periods, Penn State (2-3) out-scored Lehigh (4-3) 5-1 in the third period and stretched the run to 8-2 and give Penn State a 9-7 lead. Nevertheless, Lehigh shot back with five straight goals en route to the 12-10 win. Dante Fantoni and Patrick Corbett each had hat tricks for the Mountain Hawks.
The momentum turned in the third period as Sanders scored two quick-fire goals in a span of 45 seconds, cutting Lehigh's lead to 5-3 with 12:16 remaining in the third. Lehigh pushed the lead back to three, three minutes later, but Jack Forster (Jenkintown, Pa.) scored with 7:39 left, a man-up goal from Matt Sexton (Niskayuna, N.Y.) as LU led 6-4. Forster made it 6-5 with 3:50 left off a feed from Nick Dolik (Bloomfield Hills, Mich.).
Penn State would knot the game at six on a beautiful goal from Shane Sturgis (Downingtown, Pa.), who threw it over Poillon's head with 18 seconds remaining. The play broke down when Sexton lost the ball on the left wing, Forster picked it up, tossed it over the defense to Sanders. Sanders faked the shot, fed a streaking Sturgis who cut across the crease for the goal.
Sanders continued the run in the fourth with a man-up goal from Sexton 30 seconds into the frame, taking the first lead of the second half. The lead doubled on the faceoff as Sanders scored seven seconds later.
Lehigh's Kyle Steifel cut the lead to 8-7 Penn State, but Sanders extended it back to a two-goal margin on the ensuing faceoff. Danny Henneghan (Beverly Hills, Mich.) controlled the faceoff and sent a dime to Sanders on the right wing for the freshman's fifth goal of the evening, a copycat play from two minutes earlier.
The good times halted there for Penn State as Lehigh scored the next give goals. Corbett and Fantoni tied the game with 9:15 remaining and Cody Ferraro put the Hawks up one with 6:47 remaining on an extra-man opportunity. Corbett doubled that lead to 11-9 with 5:02 remaining and Corbett finished off his fourth-quarter hat trick with 3:19 left for the 12-9 lead. Sturgis scored his second the game with three seconds remaining for the final score line.
For Sanders, it was his second straight game with five goals following last week's game vs. Ohio State. Sanders has scored at least three goals in four of his five outings and four goals three times in his young career. His six points were a career high. Forster and Sturgis each pitched in with three points on two goals and a helper.
Penn State won most of the major offensive categories led by Henneghan's sterling play at the faceoff X, going 17-for-24, which included winning 16 of the game's first 20 faceoffs. Henneghan had five ground balls and Steven Bogert (Carlsbad, Calif.) picked up six.
Penn State won the ground ball war, 31-20, and cleared at a 20-for-22 clip. Also, the Lions were 3-for-5 on the man-up, scoring as many extra-man goals on Saturday night as they had coming into the contest. PSU netminder Austin Kaut (Morton, Pa.) made seven saves, while Poillon made 11, eight of which came in the opening half.
Erik Myers (Del Mar, Calif.) scored his first of the year, slipping around the crease and floating a shot over LU netminder Matt Poillon with 7:22 remaining in the first period. The play was set up by a Kyle VanThof (Penfield, N.Y.) strip of Kurtis Kaunas as the Lehigh midfielder lined up for a shot. Lehigh answered with three straight goals; two from Dante Fantoni and one from Alan Henderson to take a 3-1 lead after a period of play.
Lehigh extended the lead to three goals, 4-1, on an Alex Drake strike from the left wing with 10:29 remaining in the second. The Mountain Hawks made it a 5-0 run when Dan Taylor flippd a goal behind his back with five minutes remaining in the second quarter.
The difference early on was the play of Poillon, who made eight saves in the first two periods. Penn State won six-of-eight faceoffs, but Lehigh out-shot the Nittany Lions 17-13. The Mountain Hawks committed 12 turnovers to PSU's eight.
Penn State opens CAA play next week at Massachusetts. The faceoff is set for 12:00 pm. in Amherst, Mass.


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Bryant, Martinez file for March Tom Green County Democratic primary
SAN ANGELO, Texas - Two Democrats filed Wednesday for ballot positions in the March primary, the Tom Green County Democratic Party chair said.
Jesse Martinez has filed for the nomination to run for Tom Green County Commission, Precinct 1, and Walter Bryant has filed to run for county sheriff, Linda Shoemaker said.
The primaries will be held March 6. Dec. 15 is the last day to file for a ballot position. For any other candidates wishing to file on the last day, Shoemaker said, she will be available on that date at 224-2944, 655-8683, or 450-0018.
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text:
Suzuki DR-Z125 2012
2012 Suzuki DR-Z125 specifications, pictures, reviews and rating
Picture credits - Suzuki. Click to submit more pictures.
|Suzuki's profilation of this bike
|Aggressively styled bodywork, number plates and graphics built to look exactly like the race winning RM-Z competition models.
|General information
|Suzuki DR-Z125
|Enduro / offroad
|Do you know this bike?
Click here to rate it. We miss 2 votes to show the rating.
|Price as new (MSRP):
|US$ 2999. Prices depend on country, taxes, accessories, etc.
|Engine and transmission
|124.00 ccm (7.57 cubic inches)
|Engine type:
|Single cylinder, four-stroke
|Bore x stroke:
|57.0 x 48.8 mm (2.2 x 1.9 inches)
|Fuel system:
|Carburettor. Mikuni VM20SS
|Fuel control:
|Digital-type CDI
|Lubrication system:
|Wet sump
|Cooling system:
|Transmission type,
final drive:
|D.I.D 428HG, 130 links
|Chassis, suspension, brakes and wheels
|Front suspension:
|Telescopic, coil spring, oil damped
|Rear suspension:
|Link type, coil spring, oil damped
|Front tyre:
|Rear tyre:
|Front brakes:
|Expanding brake (drum brake)
|Rear brakes:
|Expanding brake (drum brake)
|Physical measures and capacities
|Weight incl. oil, gas, etc:
|73.0 kg (160.9 pounds)
|Seat height:
|805 mm (31.7 inches) If adjustable, lowest setting.
|Overall length:
|1,885 mm (74.2 inches)
|Ground clearance:
|270 mm (10.6 inches)
|Fuel capacity:
|4.80 litres (1.27 gallons)
|Other specifications
|55-watt headlight. LED-type taillight
|Factory warranty:
|6 month limited warranty
|Color options:
|Further information
|Insurance costs
|Get estimated US insurance cost with a quote from Allstate Motorcycle Insurance.
|Also adventure and dirt-bike parts at CruiserCustomizing.com.
|Parts, accessories
|Our partner CMSNL ships low cost OEM motorcycle parts to Australia, Austria, Bahamas, Belgium, Canada, China, Croatia, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hong Kong, Hungary, Iceland, India, Ireland, Italy, Japan, Kuwait, Latvia, Lithuania, Luxembourg, Macedonia, Malta, Montenegro, The Netherlands, New Zealand, Norway, Poland, Portugal, Serbia, Slovakia, Slovenia, South Africa, Spain, Sweden, Switzerland, Taiwan, Ukraine, United Kingdom, The United States and more. Or check out parts and accessories from our other partners.
|Loans, tests, etc
|Search the web for dealers, loan costs, tests, customizing, etc.
|Ask questions
|Join the 12 Suzuki DR-Z125 discussion group.
|Related bikes
|List related bikes for comparison of specs.
Free motorcycle classifiedsClick here to sell a used 2012 Suzuki DR-Z125 or advertise any other MC for sale. You can list all available Suzuki DR-Z125 bikes and also sign up for e-mail notification when such motorcycles are advertised in the future. Ads with or without pictures are easy to create. Our classifieds are completely free with sections for every country in the world. You can also check out our list of related motorbikes. Compare technical data. Look at photos. View your fellow riders' rating of the bike's reliability, design, engine performance, accident risk, repair cost, etc.
Pictures, trademarks and logos of third parties are exclusive property of the respective owners. Technical specifications are subject to change without notice. Bikez.com has been developed by low-cost software development company ObjectLabs.
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text:
Academic Instructional Design
Instructional Design
The role of Instructional Design Consultant:
- • Create engaging, interactive learning experiences.
- • Find the appropriate technology to help meet course goals.
- • Support best practices for using technology in teaching.
- • Develop learning objectives and match those with teaching
- outcomes.
- • Develop effective strategies for motivating and engaging students
- in learning activities.
- • Use online communications tools and group activities to increase
- student collaboration.
- • Become familiar with available technology.
- • Design and create multimedia or other supplements to support
- teaching and learning.
Instructional design support can help you to:
Tian (Tintin) Luo
Instructional Design Consultant
Ettinger 006
Phone: 484-664-4057