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Look 4
Marlo Suit Pant in New Tailor
(see more colors)
Belvin WP Voedar Coat
Sylvain Shirt in Wealth
Marcelo Tee in Stay
The Day Job
The Modern Jean
Weekend Getaway
Look 7
Dover Spread Dress Shirt in Kenai
Sandhurst Polo in Current Pique
Look 14
Look 2
Look 8
The Slim Fit
Gesper Tee in Anemone
Collet Jacket in Extent
Mowell Sweater in Avios
Arvid L Jacket in Amorim
Packor CW Pant in Minden
Zack PS Shirt in Spiral Print
Whyte DW Coat in Reish
Dakoto FC Shirt in Harlan
Kalov Sweater in Stellio
Zack PS Shirt in Combes
Corick Vest in Aparture Print
Zack PS Shirt in Arrowsift
Ginley RSH Coat in Tash
Dryden Pant in Ryor
Vandisen S Jacket in Altus
Tobius F Jacket in Wescombe
Connor W Sweater in Protected
Aeson Tank in Fragmented
Agnoss Sweater in Cashwool
Zaine WD Pant in Haddon
Rodolf Jacket in Gleason
Rink Tee in Engineered Picque
Zack PS Shirt in Terner
Tobius F DW Jacket in Reish
Stirling Jacket in Alperton
Dimpsy Coat in Ranun Print
Riland Sweater in Gravels
Benner Shirt in Arrowsift
Stirling Jacket in Cambria
Corick Vest in Mattox
Plymouth Pant in Gleason
Tomaz S Short in Ryor
Moris Short in Deflect Terry
Balfor Cardigan in Cashwool
Plymouth CW Pant in Minden
Dagmar YC Coat in Voedar
Raffi JE Z Pant in Hueron
Look 1
Zack PS Shirt in Hazleton
Mikon Shirt in Elmsford
Guys' Night Out
The Classic Fit
Benner Shirt in Wilder
Petrik C Top in Repute
Vaugn Pant in Jetliner
Zack Top in Winterton
Zaine TT S Short in Linthal
The Big Pitch
Veron Sweater in Fengsel
Jake TX Pant in Barinas
Vetel Sweater in Cashmere 2
Bron W Polo in Kroma Silk
Marlo T U Pant in Calvary Twill
The Moto Trouser
Villen Sweater in Cashwool
Jake W Suit Pant in New Tailor
Swimmer Shorts in Kick Pool Print
Zack PS Shirt in Ostend
Zack FF Shirt in Daulton
Danen PNC Top in Replika
Marlo T U Pant in Akron
Sylvain Shirt in Amicable
Zack PS Shirt in Pritchard
Connor Top in Softshell
Danen HNC Top in Cloud Terry
Look 3
Tobius F Jacket in Tolosa
Leonaard FFL in Williston
Raffi BL in Rhine
Danek PS Sweater in Ryor
Hifi Pants in Shift
Marlo P Tuxedo Pant in Hamburg
Marlo U Pant in Blenheim
Sayer Coat in Voedar
Skodi Jacket in Clymer
Down Time
Bikor Pant in Revore
Zaine Pant in Witten
Haydin Je N Z Pant in Monford
Velay Sweater in Cashwool
Look 9
Lunge Mid Pants in Rewarded
Edon C Sweater in Cashwool
Bradley Pant in Brasted
Barham C Shirt in Turini
Brettos Sweater in Bilen
Elk J Pant in Bilen
Spec P Tee in Encase
Packer Z Jacket in Kick
Zaine TT Pant in Revore
Volter SP Coat in Catalyst
Zack PS Top in Horton
Jalt Vest in Brinton
Moris P Pant in Static Terry
Raffi Je N Z Pant in Motley
Carles Coat in Allingdale
Zack PS Shirt in Armorel
Sten S Short in Entick
Beckit SW Z Short in Odium
Jake W Pant in Cambria
Nordan Sweater in Bilen
Zaine F Pant in Penury
Iggers Sweater in Bilen
Soler Sweater in Innka
Haydin Je N Z Pant in Rigg
Raffi Je Z Pant in Garrett
Kerek Coat in Ozarke
Johan Coat in Neoteric
Lencia Coat in Ventnore
Dekker Top in Atmos
Egall Sweater in Castelle
Semour Top in Jetliner
Grasberg Cardigan in Cashwool
Dover Spread Dress Shirt in Lingham
Look 5
Laurens HL Coat in Berne
Niles Coat in Allingdale
Danen HNC Top in Collision Terry
Zack PS Shirt in Rostock
Belvin WP Coat in Leary
Zack FF Shirt in Ananda
Look 15
Zaine SW Pant in Neoteric
Rodolf CF HL Jacket in Straslund
Wimso Pant in Ventnore
Haydin Pant in Writer
Connor Top In Fractal Grid
Kazey DF Coat in Altus
Billey HNC Top in Kroma Silk
Marlo U Pant in New Tailor
Zaine S Short in Fawe
Ross Cardigan in Stellio
Hallsey Coat in Berne
Zack PS Shirt in Verlyn
Volter SP C Coat in Catalyst
Dillan Coat in Fuel Canvas
Carick UL Jacket in Neoteric
Belvin WP Coat in Walgrave
Jake W Pant in Haddon
Ivann Cardigan in Cashwool
Efron Shirt in Ranunculus Print
Stirling Jacket in Ortley
Ript T Tee in Encase
Lacham Cardigan in Innka
Sylvain Shirt in Corner Print
Jake W Pant in Carling
Koree VS Tee in Zephyr Melange
Vilass Sweater in Admiral
Lumo Pant in Horton
Marlo U Pant in Wulfert
Ivo Sweater in Innka
Jake W Pant in Alperton
Haydin JE N Z Pant in Linthal
Lumo S Short in Hazleton
Allon Coat in Altus
Danen HNC Short in Collision Terry
Silas Shirt in Sedburgh
Marlo T U Pant in Prosperous
Zaine F Pant in Heyward
Dover Point Dress Shirt in Pritchard
Branson SH Coat in Aphex
Look 10
Dimpsy Coat in Taboga
Danen Sweater in Static Terry
Kelso L Coat in Delro
Protector C Jacket in Rowing
Moris PNC Pant in Collusion Terry
Lumo Pant in Restefond
Derrell Coat in Taboga
Tobius F Jacket in Carling
Houst E Tee in Encase
Dillan Coat in Newlyn
Kenri SC Coat in Vodear
Lowel Coat in Gerridge
Samson L Coat in Divert
Antony L Coat in Amorim
Rodolf CF Jacket in Clymer
Byrne L Coat in Rhine
Tobius SL Sportcoat in Newlyn
Raffi Je Pant in Railton
Lunge S Shorts in Rewarded
Rodolf CF Jacket in Heyward
Bedros Tee in Stay
Zack PS Shirt in Sever Print
Zaine F Pant in Newlyn
Juden Coat in Fuel Canvas
Zack PS Shirt in Tanna
Lunge Pants in Rewarded
Zack PS Shirt in Instrumental LT
Brondby Sweater in Castelle
Malvo Sweater in Hemmets
Dover SPR Top in Vondele
Moris Short in Static Terry
Sylvain Shirt in Wealth
Strider SP Shorts in Kick
Coppolo Shirt in Kenai
Boyd Polo in Census
Marlo U Pant in Mazuma
Danen Sweater in Deflect Terry
Ashlon Altus Vest
Dannis Coat in Brinton
Tobius F SL Jacket in Amado
Crayne Shirt in Rewarded
Winslo Sweater in Stellio
Andrion SN Tee in Illusion Stripe
Arsenalle Sweater in Vilket
© 2015 Theory


text:
2010 Dialogue for Action
The 12th Annual Dialogue for Action on Colorectal Cancer Screening: Prevention Hits the Headlines was held in Baltimore, MD on March 24-26, 2010.
This dynamic conference brought together a multidisciplinary group of 160 health care professionals and advocates hailing from 30 states, the District of Columbia, several tribal nations and urban Indian health organizations to discuss CRC screening against the backdrop of dramatic changes in the health care system.
The 2010 conference agenda included timely presentations and engaging small-group discussions on community prevention, the emerging role of preventive services, featuring CRC screening, in the changing health care system and elements that contribute to successful programs on a shoestring budget.
Of the dialogue attendees, 28% were state of local health department representatives, 22% were nurses and 42% have medical practices in suburban and rural locations.
Click below to see information on the 2010 Dialogue for Action:

subset: commoncrawl


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Active and Passive Voice
By Mark Warner
Age Range: 7 to 11
Age Range: 7 to 11
The two resources below can be used when children are learning about the active and passive voice of verbs:
- Print the poster and use it on a class display.
- Laminate the poster and let children refer to it during their independent writing.
- Challenge pupils to think of their own sentences and change them so that the verbs are in the active / passive voice.
- Put children into pairs and ask them to write sentences in the active voice. Their partner has to change these so that they are written in the passive voice. Repeat the activity, changing from passive to active voice.
- Use the activity sheet to reinforce / assess children's understanding.
Active and Passive Voice Poster
Active and Passive Voice Activity Sheet
Find more of our vocabulary resources here and our SPaG (Spelling, Punctuation and Grammar) resources here.
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Posted: Friday, November 9, 2012 10:41 AM
Pregnant women are absolutely gorgeous and sexy. Seeking a pregnant woman who would like to meet for some clean and discreet fun. If your man left you in the dust or is not into you now that your pregnant he must be crazy but I'd like to talk with you and we can take it from there. Email me.
• Location: Long Island
• Post ID: 34575878 newyork


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|Print Page
|Veronica Cazares, number 8, and Kara Palmer, number 25, compete against each other in a scrimmage on Sept. 1 after a forfeit by Granite. Coaches Tanya Henrie and Dave Capalbo used the forfeit by Granite as a chance to get in some real practice by dividing the team into two.
Carbon High's girl's soccer team is getting better and better during each game they play. The Dinos are now third in the region after beating Grand but losing to North Sanpete in the last week.
Last Thursday the Dinos played Grand, a team from Moab, at Carbon.
It was a tight game between the two extremely competitive teams. Neither team scored during the first half with a 0-0 halftime score.
The girls ended up pulling in a win, ending the game 3-2.
The Dinos were led by Samantha Smith in the game, who scored two goals, and by Brenda Davis, who added a goal as well.
This win launched the Dinos into third place in Region 8 with six region points.
Tuesday, the team traveled to North Sanpete. The girls took an early lead just one minute into the game.
It was 2-0 about five minutes after that before turning into a dogfight between the two competitive teams.
North Sanpete scored, going to 2-1. Then they scored again, 2-2.
Then Carbon scored, pulling back into the lead at 3-2. Then North Sanpete scored again tying 3-3 at the half.
Carbon went back into the second and got a couple more scores early in the second half and led 5-3 with about four minutes left in the game.
North Sanpete tied it up right at the end of the half, 5-5.
Carbon and North Sanpete then headed into a 10 minute golden goal overtime period. North Sanpete scored a couple of minutes into the overtime, ending the game and taking the win.
Carbon dominated the entire game until then but came away with a devastating loss after taking the game into overtime.
Patricia Smith led the Dinos with two goals on her own. Brandi Karren, Tiz Smith and Samantha Smith all scored for Carbon as well.
The Dinos are currently holding strong in third in the region and it is possible that they will still move up to second. They currently have four wins and five losses total and one win and two losses in the region. Delta is just ahead of them in the region with three region wins and just one loss. Delta is 3-5 in total.
The girls seem to be getting more confident all the time. The Carbon team is still a young program, but seems to be doing better each year they play. This year just might be the best they have ever had. The Dinos are on the verge of making the state playoffs for the first time ever in their short six year history as a team. Two more wins should get them into the playoffs and they still have six more region games to play.
The Dinos will be taking on the tough Juan Diego team later today at 3:30 p.m. This will be an away game.
Having three region wins and no region losses this season, Juan Diego is holding their own as one of the leading girl's soccer teams in the state and have not been scored on so far this season in region games. Juan Diego might bring some tough opposition to the Dinos. Carbon plans on being the first in the region to score on Juan Diego and with how great the girls have been playing, shouldn't have a problem doing so.
|Print Page


text: Enter to win an Apple iPad from OnSugar Want to win a brand-new Apple iPad? All you have to do is blog with OnSugar — yes, it's that easy! Just create three posts between March 1 and March 29 and you could win! The more you write, the more times you're entered!


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The purpose of the Maryland Housing Rehabilitation Program- Single Family (MHRP-SF)
is to preserve and improve single family properties and one-to-four unit rental
properties. MHRP-SF is a program designed to bring properties up to applicable building
codes and standards.
MHRP-SF funds may be used to assist in the rehabilitation of owner-occupied single-family
homes and rental housing with one to four units.
Household income of owner-occupants of single family homes and all residents of
financed rental housing cannot exceed 80 percent of the statewide or Washington,
D.C. MSA median income. The interest rate for these loans is a minimum of 4.5 percent
and is determined based upon the owner-occupants ability to repay the loan, or for
rental units, the project's income available to repay the loan.
Loans that benefit families with incomes that are 60 percent or less of the statewide
or Washington, D.C. MSa median income have lower interest rates of 4.5 percent or
less and are based upon the owner-occupants ability to repay the loan, or for rental
units, the project's income available to repay the loan.
Loans have interest rates based on the income of tenants served and projected income
available to repay the loan. Generally, the maximum loan is 110 percent of the value
of the property. Loans in excess of $5,000 or with deferred payments are secured
by a mortgage. The maximum loan term is 30 years. Loans which serve families with
incomes at or below 50 percent of the statewide or Washington, D.C. MSA median income
may have deferred payments if necessary for project feasibility.
Loans should accomplish the following: correct exterior and interior deficiencies;
make accessibility modifications; correct health and safety violations; improve
weatherization and energy conservation; and correct lead-based paint violations.
General improvements are eligible for financing after renovation of the priority
items listed above. Luxury items such as swimming pools and recreational facilities
are not eligible for financing. General improvements include small addition, alteration,
carpeting; fences and landscaping, kitchen, bathroom, or closet remodeling.
Generally, all loan requests are processed directly by local governments for properties
within their jurisdiction.
Applicants should contact their local housing office or DHCD's Single Family Housing
at 410-514-7530 (within the Baltimore area) or 1-800-638-7781.
MHRP-SF loans are originated, packaged and closed by the Maryland Department of
Housing and Community Development Special Loan Program's (SLP) network of local
administering agencies. The network includes the county housing and community development
offices as well as nonprofit organizations.
List of local contacts by County
Single Family Housing
Community Development Administration
Maryland Department of Housing and Community Development
7800 Harkins Road, Lanham, MD 20706
Toll Free (Maryland Only): 800-638-7781
TTY 711 or 1-800-735-2258
Contact Us
Privacy Notice
and Terms of Use
Site Map
7800 Harkins Road, Lanham, MD 20706 | (301) 429-7400 | Email Us


text:
Notebook: Another day with no sacks proves damaging for Vikings 'D'
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FOXBOROUGH, Mass. -- The Minnesota Vikings' impotent pass rush punished them again on Sunday.
New England Patriots quarterback Tom Brady completed 16 of 27 passes for 240 yards, a touchdown and a 100.8 passer rating in a 28-18 win while taking only three hits and no sacks -- extending the Vikings' franchise-worst streak to three games without a takedown.
"We pride ourselves on stopping the run and making plays like that," right end Jared Allen said, "but it comes to a point where we've got to figure something out. We know teams are going to do certain things against us, but we had opportunities (Sunday) and we had opportunities the last couple weeks. We have opportunities every game. So, we've just got to take advantage of them."
That's been easier said than done for the Vikings, whose last sack came on the first play of the third quarter Oct. 11 against the New York Jets.
A year after leading the NFL with 48 sacks, the Vikings have six through seven games -- tied with Tampa Bay and Cincinnati for the fewest in the NFL. Allen, who had 14½ sacks each of the past two seasons, still is stuck on one, which he got Sept. 16 against Miami.
"In the third quarter, I have a chance to sack (Brady), but I went to strip the ball and I just missed," Allen said. "Those plays, last year, we were making. I would have gotten a sack-strip-fumble. You never know what's going to happen. So, it starts with me, and all I can do is try and get better and see if we can't get some momentum."
Not even increased pressure sent by defensive coordinator Leslie Frazier -- who mixed in more zone blitzes and some 3-3 nickel looks -- made a difference here.
The lack of pressure was no more evident than on Brady's 65-yard touchdown to Brandon Tate, who was covered well on his initial out route and a comeback before cornerback Asher Allen lost track of him down the sideline.
"I was like, 'All right, the ball's coming out,'" Asher Allen said. "And then 8 seconds later, (Brady) just threw it up deep. So, I just -- I guess I've just got to stay on him longer."
Bad day
Asher Allen was on the bad end of another key play in the fourth quarter, when his missed tackle in the flat allowed running back Danny Woodhead to turn a throwback pass into a 16-yard gain on third-and-12.
"It's unacceptable," Allen said. "Got to make that tackle."
Six plays later, BenJarvus Green-Ellis capped an 80-yard drive with a 2-yard touchdown run that all but sealed the decision.
"I think they got a little bit of their counter game going inside, pulling a lineman, and obviously they made that big play," Vikings coach Brad Childress said. "They snuck Danny backside, had Brady roll, and that one kind of broke our back."
Flag follies
One week after admitting his mistake in failing to throw a challenge flag, Childress erred by throwing one on a play that had no chance of being overturned.
Safety Madieu Williams had Brandon Tate blanketed on a post pattern and appeared to have an easy interception. But the ball somehow went through Williams' hands and then to Tate, who juggled it but held on for a 32-yard gain.
The ball never came close to the ground until Tate went down with it. Childress challenged anyway, though, and the call held up.
"Initially, I was not going to challenge," Childress said, "and then I got a holler in my ear about somebody saw a different view of it. But obviously, run it over a couple of times, he had a pretty good catch there."
Childress wasn't alone. Patriots coach Bill Belichick challenged Adrian Peterson's 1-yard touchdown run in the first quarter, even though replays appeared inconclusive at best about whether the ball crossed the goal line before Jerod Mayo knocked Peterson back.
Peterson took blame for the fourth-and-goal run that came up short late in the first half.
The Vikings put in Ryan Cook as an extra lineman along with two tight ends, fullback Naufahu Tahi and Peterson, who tried to jam the run inside even though right tackle Phil Loadholt couldn't move defensive tackle Ron Brace.
After looking at the replay, Peterson said, he should have gone outside beyond right guard Anthony Herrera's kickout block.
"That was tough for us," Peterson said. "Tough for me to swallow, because I hold myself accountable on that one."
Childress defended the decision to go for the touchdown instead of kicking a field goal that would have given the Vikings a 10-7 lead.
"The big thing was ... just to be aggressive," Childress said. "Seven points was huge there. Obviously, they kneeled down ... to get out of the half. But we thought we had a good play called there and thought we had it blocked up pretty good and gave ourselves a chance, and we were going to need seven points there, we thought, as opposed to those threes."
Asked why receiver Randy Moss wasn't on the field, Childress said, "We had 'Y' personnel and three tight ends in the game. We need our blockers in there. We didn't need our decoys in there right then."
Quick hits
• Rookie cornerback Chris Cook once again got the first chance with the Vikings' nickel defense. And once again, Frank Walker replaced him in the first half, after Cook missed a tackle on Deion Branch's 21-yard catch-and-run gain. Wes Welker blocked Cook on the play, but it still appeared he had a chance to bring Branch down. "You've got to tackle," Cook said. "We missed a lot of tackles. I am pretty sure that will be our emphasis going into next week." Cook returned to nickel duties in the third quarter.
• Tahi's 1-yard touchdown catch from backup QB Tarvaris Jackson was the second of his five-year career. He floated into the right flat and caught a floater from Jackson, who had rolled right off play action. "It took a longer than it should have, but we still executed it," Tahi said.


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Concerns surface over whether or not video cameras should be used in nursing homes to monitor staff's behavior towards residents as proposed by Illinois Attorney General, Lisa Madigan. Cameras could help deter nursing home abuse and neglect and hold those responsible when abuse or neglect occurs. The Attorney General's office is drafting a bill which would allow video cameras and audio recording devices in nursing homes as long as residents consent and they or their family can cover the costs.
Although agreeing that cameras can be helpful in cases where the resident consents, many elder care advocates are concerned about the privacy of seniors in cases where consent is difficult to determine. Many residents of long term care facilities are mentally impaired, such as those residents whose mental capacity has been affected by a stroke, claims a representative of suburban Cook County for the Legal Assistance Foundation, a senior advocacy organization. No one knows if those residents who require help in getting dressed or changing a diaper would want to be recorded.
However, Madigan and supporters of the proposal say that cameras are appearing everywhere these days, so why not allow them in nursing homes. The recordings from the cameras or audio devices would be allowed in court and anyone who tried to tamper with or obstruct the devices would be penalized under the proposal. It is no surprise that abuse and neglect in nursing homes is a growing concern. According to the attorney general's office, the Illinois Department of Public Health receives 19,000 calls per year alleging abuse or neglect and responds to about 5,000.
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We are grateful to Jennifer Lafontaine, Morena Cobbs, Sean Riley, and Judy Goldman of Pfizer Inc. for helpful discussions and biological testing, Prof. Jin-Quan Yu for mechanistic insight, Dr. Laura Pasternack for help with computations, Dr. Curtis Moore and Prof. Arnold Reingold for X-ray crystallographic measurements, and Dr. Dee-Hua Huang for NMR assistance. Financial support for this work was provided by Pfizer, Bristol-Myers Squibb (predoctoral fellowship to J. S.), the Department of Defense (predoctoral fellowship to R.A.S.), the NIH (predoctoral fellowship to C.A.G.), and the Uehara Memorial Foundation (postdoctoral fellowship to H.S.).
Stereodivergent Synthesis of 17-α and 17-β-Aryl Steroids: Application and Biological Evaluation of D-Ring Cortistatin Analogues†
Article first published online: 11 MAY 2009
DOI: 10.1002/anie.200901116
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 48, Issue 24, pages 4328–4331, June 2, 2009
Additional Information
How to Cite
Shi, J., Shigehisa, H., Guerrero, Carlos A., Shenvi, Ryan A., Li, C.-C. and Baran, Phil S. (2009), Stereodivergent Synthesis of 17-α and 17-β-Aryl Steroids: Application and Biological Evaluation of D-Ring Cortistatin Analogues. Angew. Chem. Int. Ed., 48: 4328–4331. doi: 10.1002/anie.200901116
- †
Publication History
- Issue published online: 26 MAY 2009
- Article first published online: 11 MAY 2009
- Manuscript Revised: 5 APR 2009
- Manuscript Received: 27 FEB 2009
Funded by
- Bristol-Myers Squibb
- Uehara Memorial Foundation
- angiogenesis;
- asymmetric synthesis;
- natural products
One stereocenter makes all the difference: The synthesis and biological evaluation of 17-epi-cortistatin A is reported from a common intermediate used to procure natural cortistatin A. The synthesis features a unique stereocontrolled Raney-Ni reduction process that can be employed to reliably produce both α- and β-configured D-ring aryl steroids. Biological evaluations of these "cortalogs" are reported for the first time.
Natural products have always been a successful pool of molecules from which the pharmaceutical industry can find novel medicinal agents.1 Steroids, in particular, continue to be the subject of medicinal investigations for two reasons: they are "privileged"2 pharmacophores and their scrutiny for over half a century has resulted in a vast body of knowledge regarding their reactivity.3 Recently, Kobayashi and co-workers elucidated the structures of cortistatins A–L (see Scheme 1 for the structure of cortistatin A (1)) from the sponge Corticium simplex.4 These marine derived steroidal alkaloids exhibit potent anti-angiogenic activity against HUVECs (human umbilical vein endothelial cells) by a possibly unique mechanism.4 While the Kobayashi research group has already delineated a preliminary structure–activity relationship (SAR) of the family (see Scheme 1), their scarce natural supply renders chemical synthesis as the only means to decipher their medicinal potential. Particularly intriguing is the impact of the isoquinoline moiety on biological activity since its absence significantly lowers activity. Here, we illustrate the critical influence of D-ring configuration on biological activity with the synthesis of 17-epi-cortistatin A (4). Specifically, we have found that the C-17 stereochemistry may be removed all together as Δ16-cortistatin A (2) retains much of the potency of 1. This line of chemical inquiry has also led to the first useful method for the stereocontrolled preparation of other α-aryl-substituted D-ring steroids.
Several approaches have been reported for the preparation of the core structure of cortistatins5 and two elegant total syntheses of the most potent member of this natural product class, cortistatin A (1), have appeared from the Nicolaou/Chen6a and Shair research groups.6b
Our own synthetic plan7 was profoundly affected by the strategic choice to use prednisone—a synthetic corticosteroid produced annually on multi-ton scale by microbial oxidations of naturally occurring steroids—as a starting material. Aside from economical considerations, this choice was made with the knowledge that semi-synthetic approaches have enjoyed decades of success in the pharmaceutical industry. Thus, a twelve-step sequence was utilized from this starting point to arrive at cortistatinone (3) in gram quantities.7 The synthesis concluded with a highly chemo- and stereoselective Raney nickel (Ra-Ni) mediated hydrogenation of Δ16-cortistatin A (2). In order to evaluate the importance of a β-oriented isoquinoline moiety, an estrone-derived model (5, Scheme 2) was employed as a testbed for a strategy that would deliver both epimers from a common intermediate.
By analogy to the synthesis of 2, estrone model 5 was converted to the D-ring styrene 6 a as depicted in Scheme 2. Regardless of the reducing conditions, the only observed product was the expected β-aryl substituted product 7 a. Ra-Ni mediated reduction led to a 97 % yield of isolated 7 a. This is not surprising given the fact that an overwhelming majority of nucleophilic, electrophilic, and radical substitution reactions at C-17 occur from the α-face.8 Attention was therefore turned to an alternative approach that began with tertiary alcohol 8 a, derived from addition of PhLi to 5. Based on preliminary evidence9 and a report that Ra-Ni reductions of benzylic alcohols occurred with retention of configuration,10 alcohol 8 a was subjected to Ra-Ni in toluene at reflux. A diastereomeric pair of compounds was isolated in a 6.6:1 ratio, the major isomer of which bore the desired α-configuration. The structures of 6 a–9 a were all verified by X-ray crystallography.12
The generality of this reagent system, a synthesis of 17-epi-cortistatin A, mechanistic analysis of these reductive processes, and biological evaluation of cortistatin analogues are presented below.
As shown in Table 1, both pathways (6 to 7 and 8 to 9) are amenable to the incorporation of electron rich, neutral, and withdrawn arenes, as demonstrated by the successful deoxygenations and hydrogenations of C-17 phenyl, p-tolyl, p-anisyl, and 3-pyridyl steroids. Hydrogenation of Δ16-17-arylsteroids 6 was carried out in 10 % toluene in isopropyl alcohol with Ra-Ni at 60 °C for 2 h, providing 7 with yields varying between 68 % and 98 %. The diastereoselectivity of this transformation is generally over 20:1 (17-β/17-α). Alternatively, deoxygenation of 17-β-hydroxy-17-α-arylsteroids 8 was carried out in toluene with Ra-Ni at 110 °C for 5 h. Yields varied between 68 % and 98 % with moderate to good diastereoselectivities.
To determine the source of hydrogen in the reductions, deuterium labelling experiments were carried out as shown in Scheme 3. For Ra-Ni mediated transfer hydrogenation, the reaction of 6 a was conducted in deuterated isopropyl alcohol and toluene (toluene or [D8]toluene gave identical results) with D2O-washed Ra-Ni, affording [D2]-7 a with deuterium incorporation at C-16 and C-17. For Ra-Ni mediated deoxygenation, the reaction of 8 a employed deuterated toluene with D2O-washed Ra-Ni. Surprisingly, [D4]-9 a was obtained as the major product in 96 % yield. However, 7 a and 9 a exhibited identical aromatic deuterium substitution when subjected to the same reduction conditions as 8 a, demonstrating that this aromatic deuteration is independent of the deoxygenation process.
The divergence in observed stereochemical outcome between 7 and 9 seemingly excludes the intermediacy of free-radicals in deoxygenation (89; radical deoxygenation produces β-configuration at C-17). The difference in stereoselectivity between 6 and 8 can be rationalized based on the facial selectivity of chemo-adsorption to the metal surface as depicted in Scheme 4. Previous studies11 have demonstrated that a high degree of stereoselectivity can be incurred in Ra-Ni mediated reductions based on stereoselective adsorption.
In the case of 6, adsorption likely occurs most favorably on the relatively flat α-face, away from the angular methyl group (C-18). Hydrogens and/or electrons are then transfered from the metal surface to the preferentially adsorbed face.11 In the case of 8, adsorption possibly takes place on the convex face, with interaction occuring between the surface and both the aromatic π-system and the benzylic hydroxy, followed by hydrogen/deuterium delivery from the metal.
Finally, the mechanistic requirement of an aryl group at C-17 during deoxygenation is supported by the fact that 17-β-hydroxy-17-α-(n-butyl)-estrone (10)
was inert to deoxygenation using Ra-Ni. In addition to submitting 10 to the reaction condition, a control experiment was carried out with an equimolar mixture of 10 and 8 a premixed in the same reaction vessel and treated with Ra-Ni. While 8 a was completely deoxygenated, 10 was quantitatively recovered.
The utility of the present invention is aptly demonstrated by the synthesis of 17-epi-cortistatin (4), as shown in Scheme 5. Thus, protection of the diol motif in cortistatinone (3) with TMS-imidazole, followed by treatment with an excess of 7-lithioisoquinoline in a THF/TMEDA solvent mixture at −78 °C generated an alkanolisoquinoline that was deoxygenated with Ra-Ni to deliver 17-epi-cortistatin A (4) in 16 % yield over three steps.
This substance proved crucial in testing the substrate scope/specificity of cortistatin A's biological target. The importance of this substrate is clear since the greatest modulation of biological activity in the naturally occurring cortistatins stems from structure variations of the C-17 substituent.4
In an assay to determine activity against HUVECs (carried out by Pfizer Inc.), synthetic cortistatin A exhibited an IC50 value of 2.43 nM, which is in good agreement with the reported value (Table 2).4a Remarkably, 2 still retains high potency against HUVECs, with an IC50 of 3.88 nM. This result is a significant step forward in the simplification of the overall cortistatin structure from a synthesis standpoint. However, 4 does not exhibit useful levels of activity (>1 μM). This profound difference of biological activity clearly indicates that the C-17 stereochemistry is essential for biological behavior. Modeling studies (shown in Figure 1) suggested that 1, 2, and 4 exhibit rigid architectures that differ only in the angle in which the isoquinoline moiety would be presented to the active site. Several estrone model compounds were also found to be inactive in the HUVEC screen.
|IC50 [nM]
|cortistatin A (1)
|2.43[a], 1.8[b]
|Δ16-cortistatin A (2)
|17-epi-cortistatin A (4)
|6d–g, 7a–f, 8e, 9a, 9d–e[c]
In summation, two processes were identified for the production of either α- or β-oriented C-17 aryl steroids, conveniently using the C-17 ketone as a common starting material. Because of this divergence, it is now possible to efficiently produce both epimers of C-17 aryl steroids, thus adding the α epimers to the collection of non-natural biomolecules available for biological and other studies. The relevance and utility of such a transformation has been demonstrated by the synthesis of 1, its epimer 2, and biological evaluations thereof.12 Finally, the compelling finding that 2 retains much of the potency of 1 should considerably simplify SAR studies in this family.
Experimental Section
General procedure for the standardization of Raney nickel (Ra-Ni): Raney 2800 Nickel (ca. 1 g of a 1 g mL−1 slurry in H2O, pH 9, Sigma–Aldrich) was placed in a vial. The water was removed by pipette, and the Ra-Ni was washed by 5 s of shaking, followed by removal of the supernatant: first H2O (2×2 mL), then saturated aqueous Rochelle's salt (2×2 mL), then H2O (10×2 mL). After all washes, the Ra-Ni aqueous solution (pH 7) was stored under H2O (1 mL).
General procedure for hydrogenation: To a solution of styrene in iPrOH/toluene (9:1, 0.01 M) was added the suspension of Ra-Ni prepared above (the Ra-Ni suspension was removed by 5.75′′ pipette from the thick bottom layer of the vial; one drop suspension per 0.1 mL solution). The reaction flask was immersed in an oil bath preheated to 60 °C and stirred vigorously for 120 min. After cooling to ambient temperature, the reaction mixture was passed through Celite, the Ra-Ni washed with CH2Cl2, and the combined filtrates were concentrated in vacuo. The product was purified by flash column chromatography.
General procedure for deoxygenation: To a solution of alcohol in toluene (0.01 M) was added the suspension of Ra-Ni prepared above (the Ra-Ni suspension was removed by 5.75′′ pipette from the thick bottom layer of the vial; one drop suspension per 0.1 mL solution). The reaction flask was immersed in an oil bath preheated to 110 °C and stirred vigorously for 5 h. After cooling to ambient temperature, the reaction mixture was passed through Celite, the Ra-Ni washed with CH2Cl2, and the combined filtrates were concentrated in vacuo. The product was purified by flash column chromatography.
- 1Nat. Prod. Rep. 2007, 24, 1225–1244., , , ,
- 2Burger's Medicinal Chemistry and Drug Discovery, Vol. 5 (Ed.: M. E. Wolff), Wiley, New York, 1997, pp. 281–376.
- 3Chem. Rev. 2003, 103, 2019–2033.,
- 4
- 4aJ. Am. Chem. Soc. 2006, 128, 3148–3149;, , , , , ,
- 4bTetrahedron 2007, 63, 4074–4079;, , , , ,
- 4cTetrahedron Lett. 2007, 48, 4485–4488;, , , , , ,
- 4dBioorg. Med. Chem. 2007, 15, 6758–6762;, , , , , , , , , ,
- 4eBiosci. Biotechnol. Biochem. 2008, 72, 2992–2997., , , , , , ,
- 5
- 5aHeterocycles 2009, 77, 157–161;, ,
- 5bAngew. Chem. 2008, 120, 6752–6755; Angew. Chem. Int. Ed. 2008, 47, 6650–6653;, , , ,
- 5cOrg. Lett. 2008, 10, 3413–3415;, , ,
- 5dTetrahedron Lett. 2008, 49, 5931–5934;, ,
- 5eTetrahedron Lett. 2008, 49, 6610–6612;, ,
- 5fTetrahedron Lett. 2008, 49, 6613–6616;, , ,
- 5gTetrahedron Lett. 2008, 49, 7078–7081;, , , ,
- 5hOrg. Lett. 2008, 10, 5247–5250;, , ,
- 5i
- 5jTetrahedron Lett. 2009, 50, 2685–2687;, ,
- 5kChem. Commun. 2009, 662–664;, , , , , , ,
- 5lFor a review, see: Angew. Chem. 2008, 120, 9529–9531; Angew. Chem. Int. Ed. 2008, 47, 9389–9391., ,
- 6aAngew. Chem. 2008, 120, 7420–7423; Angew. Chem. Int. Ed. 2008, 47, 7310–7313;, , , , ,
- 6bJ. Am. Chem. Soc. 2008, 130, 16864–16866., , ,
- 7J. Am. Chem. Soc. 2008, 130, 7241–7243., , , , ,
- 8Steroids, Reinhold, New York, 1959., ,
- 9
- 9aC. A. Guerrero, Ph.D. Thesis, The Scripps Research Institute, 2008;
- 9bR. A. Shenvi, Ph.D. Thesis, The Scripps Research Institute, 2008.
- 10
- 10aBull. Chem. Soc. Jpn. 1961, 34, 774–778;, ,
- 10bJ. Org. Chem. 1988, 53, 432–434., ,
- 11Bull. Chem. Soc. Jpn. 1970, 43, 2143–2152, and references therein., , ,
- 12See Supporting Information for detailed experimental procedures and copies of all spectra. CCDC 721528 (6 a), 726038 (7 a), 721529 (8 a), 721530 (9 a), and 721527 (10) contain the supplementary crystallographic data for this paper. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data_request/cif.
Supporting Information
Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors.
|miscellaneous information
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.


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Help Center
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Web development tools
There are a number of free development tools you can download and use to help you create and test your web content or application for use on a BlackBerry device.
To download any of the BlackBerry web development tools, visit http://na.blackberry.com/eng/developers/resources/devtools.jsp.
BlackBerry Smartphone Simulator
The BlackBerry® Smartphone Simulator includes the BlackBerry Browser and other BlackBerry device applications that are typically available on BlackBerry devices. You can use the BlackBerry Smartphone Simulator to test your web pages in the BlackBerry Browser.
You can download the BlackBerry Smartphone Simulator for multiple BlackBerry devices so that you can test functionality and layout across different devices.
BlackBerry Web Plug-in for Eclipse
The BlackBerry® Web Plug-in for Eclipse® is an extension for a your existing Eclipse development environment that provides you with the tools for creating BlackBerry Web and Widget applications, and for profiling, debugging, and testing code that is designed for the BlackBerry within the Eclipse development environment.
You can use the profiling tools to track project resources and produce efficient web pages that you design for the BlackBerry Browser.
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The BlackBerry® Web Plug-in for Microsoft® Visual Studio® provides you with the tools for creating BlackBerry Web and Widget applications, and for profiling, debugging, and testing code that is designed for the BlackBerry Browser from within the Microsoft Visual Studio development environment.
With the BlackBerry Web Plug-in, you can use familiar tools for web development while you use features provided with the BlackBerry Web Plug-in to develop code and test it in the BlackBerry Browser. You can also design and develop standalone widget applications.
From within Microsoft Visual Studio, you can set break points, debug, and step through linked-in and inline JavaScript code in ASP.NET projects.


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The staff of the Stellwagen Bank National Marine Sanctuary and their colleagues in underwater exploration at National Oceanic and Atmospheric Administration and University of Connecticut have re-created through computer models and sound imaging the last, and unfinished, voyage of the Portland that went down in raging seas and a blizzard. They have produced a visual, three-dimensional model of the Portland and seas that killed her nine hours into a voyage ahead of storms from Canada and the Atlantic seaboard that terrified the ship's doomed company as they recognized there was no escape. All the crew and company perished. Only 34 bodies were recovered,
Amid laughter and family reunions last week during the100th observance of Centerville Old Home Week, a scientist from the Sancutary office in Scituate presented the fruits of the examination by cameras, instruments and an undersea robot of the Portland, which now lies deep and, so far, beyond man's unaided eye. The illustrated lecture by Benjamin Cowie-Haskell presented a somber side of life in communities like 19th-century Centerville, their fates linked to the sea and its perils as well as the convenience and prosperity it made possible.
Cowie-Haskell described the afternoon when the Portland left a calm port of Boston for the last time, and the odds lengthened minute by minute against her passengers and crew ever reaching land alive again. Besides being chased north by the rising storm, even little things were conspiring against the people surviving, The captain made a lonesome decision to set forth from Boston despite the dangerous storm warnings because he knew his little daughter in Maine wanted him home for her birthday party. A number of passengers wanted him to push on; they had been away for Thanksgiving and were impatient to get home.
They were hardly outside Boston Harbor when snow began. The waves rose higher and soon towered over the ship. The bottom nearly dropped out of the ship's barometer. The wind rose faster. The ship's paddle wheels were swept away into the awful night At 9:30 the next morning, the Portland is believed to have foundered and sank in the waves, "It was a meteorological bomb," Ben Cowie-Haskell said of the day. The vivid visual presentation of the Portland's end and the way she looks now, on keel nearly 500 feet below the waves is a moving experience for anyone to follow 100 years later.
Ben Cowie-Haskell, 42, has participated in much of the research to ascertain exactly where and how the Portland lies. Remote control cameras have produced many images of the ship at last tranquil on a smooth sea bottom. She has robbed back some of man's creations, which may have held her rusty wooden hull together, There are piles of fishnets caught along her decks, a mountain of rope and other gear snagged by the Portland as they were dragged or towed across her decks by a century of fishing boats.
Even without storm and death, the Portland and the transportation system it represented would have been doomed at the end of the 19th century. She was a beautiful, gracious vessel, but the trains were taking over to speed tourists to Bar Harbor and cotton bales to Fall River. Now the shipping lanes are made of asphalt. "Those waters were the Route I-95 of their day," Ben Cowie-Haskell said.
He prefers the old way, to learn from memorabilia of older times and solve mysteries that nobody yet has bought up from the sea. Somewhere on the Stellwagen Bank there's a Lockheed P-38 fighter plane lost on a World War II mission. Ben knows pretty much where. Now to find it.
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716-792 Avocado Avenue
El Cajon, California, 92020
Commute to Downtown El Cajon
Some errands can be accomplished on foot.
Score Details
716-792 Avocado Avenue has a Walk Score of 68 out of 100. This location is Somewhat Walkable so some errands can be accomplished on foot.
This location is in El Cajon. Nearby parks include Wildmere Park, Renette Park and Park.
Explore how far you can travel by car, bus, bike and foot from 716-792 Avocado Avenue.
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Popular apartment searches include pool, fireplace and fitness.
Find a El Cajon real estate agent who knows walkable neighborhoods. Links will open on our partner site Redfin.com.
This location is in the city of El Cajon, CA. El Cajon has an average Walk Score of 52 and has 99,478 residents.


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Animated Standing Groom
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Hi coolkids!
I've been a busy busy girl – but I thought I would stop for a second to let you all know that it's TAX TIME yey!
If you're like me, you're probably a little confused when it comes to irp5's and 12's and all that crap that goes along with being a model citizen.
Some of you naughty's haven't even registered for tax yet. You should – you might get some money back – and who doesn't like money?
Anyway, the point of my post is that I was approached by Tax Tim to help me with my tax return form etc etc
They sent SUCH a cute "SARS Survival Kit" consisting of a calculator, a mini bar one and a face mask and a tiny capsule with a Tax Tim voucher – don't worry there's something for you in there too!
What you need to know: Tax season opens on 1 July and runs until 22 November 2013. During this time, salary earning taxpayers are expected to complete their 2013 income tax returns (an ITR12 form) and submit them to SARS. The 2013 tax return covers income earned for the 2013 tax year, which is from 1 March 2012 to 28 February 2013.
Tax returns can be submitted in person at a SARS branch near you (be prepared to stand in a lengthy queue and bring every single document with you, along with a good amount of patience!) or online via SARS eFiling. Failing to submit your return on time can result in penalties of R250 per month and interest on any amounts owing. Add to this the fact that SARS will withhold any refunds due to you if penalties are outstanding and it makes sense to submit early and on time. Any mistakes made on your return for lack of "due care" can result in penalties of anywhere between 50% and 200% of the tax value of the mistake being charged against you, so if you are unsure, rather make the effort to find proper assistance and do things correctly from the start.
Depending on your individual situation, you will need the following documents in order to complete your tax return:
- · IRP5 – this describes your income earned and the tax already paid to SARS as a result of it. This should have already been received from your employer, and if not you can demand it.
- · IT3b and IT3c – these are investment certificates received from the bank and other financial institutions that describe interest or dividends you earned. If you did not receive these you can ask your bank for copies.
- · Medical Aid certificate as well as all copies and proof of payment of any "out of pocket" medical expenses prescribed by a medical practitioner that you might have paid.
- · Donations certificates made to registered PBOs (charities). Only your donations to PBOs that are accompanied by a certificate will count as a tax deduction.
- · Pension Fund, RAF and Income Protection contribution certificates received.
Get all of these documents together along with anything else which describes income earned or tax you have already paid. Sit down with a cup of hot coffee and take your time completing your ITR12 to the best of your ability. All said and done you will probably only need an hour, and can then relax and look forward to a tax refund appearing in your bank account in a matter of days, if you are due one. Taxpayers wanting to know if they qualify for a refund can try TaxTim's new interactive tax refund calculator available at www.taxtim.com/refund.
So that's all there is to it. Keep proper records during the year, take it slow and steady, and find out the answers to all of your questions before you begin and you will have nothing to fear this tax season. Hopefully you will end up with a little extra cash in your pocket this winter after doing the right thing and filing your return.
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North Fairfield library
NORTH FAIRFIELD - September is library card sign-up month. With a library card one can:
Check out books by yourself or for someone else.
Get the latest CD's.
Watch the newest movies (for free).
Download an ebook to your MP3.
Request specific books, movies, etc online from your home.


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How to Tell if a Cow or Heifer Is Pregnant
Knowing if a cow or heifer is pregnant can determine your bottom line, which is dependent on the sexuality of the cow.and thus is important to your breeding operation. Open cows, or non-pregnant cows, are considered free-loaders because they get away with eating the feed you give them but give nothing in return. These cows can hurt your pocket book, and the sooner you get rid of them, the better. Thus, knowing if a cow is pregnant or not can determine whether that cow is worth keeping until she calves, or if she should be culled and sold as soon as possible.
1Watch them after they've conceived. After breeding season or after your cow[s] or heifer[s] have been Artificially Inseminated, watch your cows for any signs of estrus for the next 45 days. If any of the females have not gone into estrus, first ~21 days after being bred then another ~21 days later, then they are most likely pregnant.
- If any of your females do come into heat during this period of time, then they're open or not pregnant.
- You can also tell if a cow or heifer is pregnant by seeing if their belly grows or not, especially during late gestation.
2After 45 to 120 days have passed, get them in to the vet or in a handling facility (if you have one on your farm), to get them preg-checked.
- There are four (4) different methods to preg-check cows, in order of the cheapest and most commonly used to the most expensive and less used for cattle producers:
- Rectal Palpation
- Blood Test
- ELISA (Enzyme-linked immunosorbent assay) test
- Ultra-sound
- The most likely method your vet will use is rectal palpation.
3Record the tag number, name, if the cow or heifer is bred or open, and how far along she is. Any females that are open should be culled, because they will only bring down any profits you intend on making next year at weaning time.
4Release the female that has been tested on and move on to the next one.Ad
Give us 3 minutes of knowledge!
- Use the best preg-checking method that is recommended by your vet or what is accessible to you.
- The best time to sell cull cows is when they are confirmed open, or even when a cow that has been on the short-list for a period time does come up bred. Bred cows sell for more than open ones.
- Check all of your heifers and cows, no matter if you are positive that a particular female is open or not.
- Heavy-pregnant cows are quite easy to spot because they look like big barrels with a head and four legs.
- Some preg-checking methods, like rectal palpation, blood testing and the ELISA test, can produce false results.
- The ELISA test is more prone to results coming up as false positives or false negatives, especially if some of the steps in the test are not followed to a T.
- Blood testing can produce unreliable results if test were accidentally swapped or if an inadequate blood sample was collected.
- Rectal palpation can also produce false results if the person carrying out the procedure is not experienced enough and/or does not know what to feel for.
- False heats when a cow or heifer is pregnant is rare, but can occur occasionally. This is why double-checking with the methods mentioned above is highly recommended to do.
Article Info
Categories: Cattle
In other languages:
Español: saber si una vaca o novilla está preñada, Italiano: Riconoscere la Gravidanza nei Bovini, Português: Saber se Uma Vaca ou Novilha Está Grávida, Русский: определить, что корова или телка беременна
Thanks to all authors for creating a page that has been read 104,607 times.


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Snag a room at a downtown Boston hotel near top shopping on Newbury Street for as little as $189-$199 per night.
Visit the Marriott Boston Copley Place Nov. 23-26 or Dec. 9-30 to slash up to 45% off surrounding dates, including Thanksgiving and Christmas.
On site, guests will find a sports club featuring workout equipment and an indoor pool. There is also a restaurant, lounge and Starbucks Coffee at the hotel. Sports fans should note that Fenway Park is just a half mile away.
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Forms Jobs
401 Robbins Road
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- Filed Under
The Missouri Department of Conservation is offering a canoeing program for women June 17 as part of its Discover Nature Series. Participants will meet at the MDC office, 2630 N. Mayfair Ave., and will be transported to and from the James River for a five-mile float trip. MDC staff will offer guidance during the float.
Women ages 14 to 17 must be accompanied by a participating adult. Participants are responsible for their own lunch and refreshments. No alcohol will be permitted.
To register for the free program, call the MDC regional office at 417-895-6880.


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- Address: Calle 85 Este and Vía Cincuentenario
- Hours: 9am – 4:30pm Monday to Saturday, 9am to 1pm Sunday
- Admission: US$6
Panama City ATTRACTIONS See all
Panama Viejo Ruins
Though Panama City is considered "Oldest Permanent European Settlement on the Pacific," the original Panamá Viejo (Old Panama) was abandoned after a devastating 1671 attack by Captain Morgan's pirate army. Today, you can wander its worn remains, including the old cathedral and several stone buildings and walls.
The juxtaposition with modern Panama City, visible across the bay, is startling. Fascinating finds from ongoing archaeological excavations are displayed at the onsite museum.


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HAJI TOOLS is the name people recall for stainless steel fasteners in chennai.
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… departmental stores, garment, textile, toys, gift shop, optical store, mobile phone, computer hardware and many other retail/distribution outlets.
We offer comprehensive business process automation covering…
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MAX2CS is one of the fast growing IT Company Through its Innovation Network, and Solution accelerators, MAX2 focuses on providing Software as well as Hardware solutions for all sorts of Business Needs and plac…
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Cholan Technology provide high quality on site services for software development and the end users on a broad range of hardware & software platforms with latest technologies Cholan Technology is structured as …
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departmental stores, garment, textile, toys, gift
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We offer a wide range of hardware and software services that include sales and services of Desktop PC's, laptops and other peripherals on one hand and providing software solutions and software training on the…
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We take this great opportunity to introduce our firm as a ISO-9001 Company and one of the Largest Stokist in India for all kinds of Lifting Tackles and Handling Equipments. We are Authorized Distributors and Dealers…
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PRCC has acclaimed the helm of corporate business houses in providing complete IT infrastructure right from hardware, software, after-sales & service, virtual marketing and telecom services
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Embedded Systems Solutions has been a leading one stop provider of hardware and software solutions for the embedded realtime systems market Embedded Systems Solutions is an Electro Systems Associates group comp…
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South India's most promising hardware and Networking training institute, be it professional or personal, computers have become an integral part of our lives
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We at BKS systems are providers of complete hardware and software solutions for corporate as well as home users Within our coverage area we can send an engineer out to your business or home
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So, I have used Pdf995's PDF print driver from a web browser to print web pages and eventually use PdfEdit995 to join these various PDF files into one large PDF.
Now I have a lot of large PDF documents that I wish to add bookmarks to, but am hoping there is a relatively easy way of doing this programmatically (using C#, preferably) - basically, I want to find, within each PDF, text that is large enough to qualify as a header, and use that text as the bookmark.
Any tips/advice/direction? Thanks!


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Khloe Kardashian Makes a Major Statement in "F--k Yo Fur" Faux Fur Coat: Picture
Now this is what we call a fashion statement. Khloe Kardashian turned herself into a walking anti-fur advertisement when she hit the streets in New York City on Monday, Feb. 17, wearing a huge faux fur coat with the words "F--k Yo Fur" scrawled on the back in bright red spray paint.
The reality star, 29, tweeted about her look shortly after stepping out, writing, "F--k Yo Fur!!! Fake fur all day, people!!" She also posted a video showing the brown and white coat up close.
PHOTOS: Khloe's body evolution
This is not the first time Kardashian has spoken out against wearing fur. Back in 2008, she posed completely nude in a PETA ad, alongside the tagline, "Fur? I'd rather go naked." Writing about her involvement with the campaign on her blog, she said, "I am done with fur forever and I have now found so many amazing faux fur lines that are great alternatives for women who love the look and love animals."
PHOTOS: Khloe and Lamar, the way they were
The DASH co-owner later cut ties with PETA when a woman associated with the organization threw flour on her sister Kim Kardashian, but she pledged to continue to not wear fur. "Everyone is entitled to their own beliefs and opinions -- I personally don't wear fur, but that doesn't mean I am going to force my view on anyone else, ESPECIALLY by violating them," she shared on her blog.
PHOTOS: Kardashian family album
"We all need to practice what we preach," she added. "I will still continue to NOT wear fur, but I will no longer support PETA."
Tell Us: What do you think of Khloe's anti-fur faux fur message?


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Patricia Interior Designs Macomb County, Michigan
Patricia Interiors is an Interior Design firm located in Shelby Township, Michigan that provides a full range of design services and space planning for residential and light commercial clients throughout Macomb and Oakland County, Michigan . Our Interior Design firm is proud to say that we develop innovative, effective, and aesthetic designs. From the first visit, to the final phase, our firm will provide attention to details with the highest standards in products used today through out the Interior Design and Custom Drapery industry.
Contact Us
Phone: 586.739.0080
Fax: 586.739.3863


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I-9 Employment eligibility verification
Employee Action Authorization (EAA)
This form should be used for new hires, rate change or employee address change.
Rate changes: Supervisors complete this form to give an employee a pay increase-on or before the effective date (all pay increases are effective on either the 1st or the 16th of the month).
New hires: Employees must bring the EAA form completed and signed by their Supervisor (and Contract Manager, if necessary), along with documents that establish identity and employment eligibility, to University Enterprises, Inc. Human Resources office during orientation hours.
Separation from Employment Procedures
Information regarding Voluntary and Involuntary employee termination.
Separation from Employment Form
This form should be faxed to UEI Payroll Services prior to the employee's last day.


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Extra Virgin Coconut Oil (All brands)
894 reviews
90% would repurchase
Package Quality: 3.6
Price: $$
Package Quality: 3.6
Price: $$
INGREDIENTSCocos nucifera
on 7/29/2013 5:28:00 AM
Age: 36-43
Skin: Sensitive, Fair, Neutral
Hair: Brunette, Curly, Fine
Eyes: Blue
UPDATE -- After using EVCO for years, I have come to understand more about when it works and when it doesn't. I've found that when I use most natural shampoo/conditioner pairs, the oil sinks into my hair, making it healthier and reducing frizz. When used in conjunction with other products, however, especially conditioners that seal the hair, the EVCO doesn't work at all, leaving my hair looking somehow oily and dry at the same time. Maybe the other products that reviewers are using explain some of the mixed results.
I can't believe that I haven't reviewed this yet. I have been using it in my hair for years. I have probably been putting the review off because it's been hard for me to find a shampoo/conditioner pair that I'm happy with and not allergic to, so I've been feeling for the longest time that perfect hair is right around the corner. Perfection has yet to materialize, but no matter what shampoo/conditioner I use, adding a bit of coconut oil every morning to my freshly washed or freshly rinsed hair (I shampoo every three days) seriously improves the way my hair looks. I put slightly more oil in my hair on days that I wash than on days that I rinse, but I never put on more than one to three dips of my fingertip up to the first joint into the liquid oil. I have found that different brands of EVCO seem to work quite differently -- I don't know why. I use Garden of Eden (the one pictured above), which melts into my hair and, although my hair isn't frizz-free (the reason I'm giving it four lippies and it has just missed HG status for me), it allows it to be healthy, and I am able to wear my curls down instead of pulled back into a ponytail. I have even, on occasion, gotten compliments on my hair, which never happened before I started using EVCO. When I used Spectrum brand, however, the oil just sat on the surface of my hair, leaving it un-moisturized, yet still greasy.
Overall, I am very happy to have found an EVCO that works for my hair. It allows my thick, course, yet easily weighed down hair to be healthy and curly.
on 7/25/2013 6:04:00 AM
Age: 25-29
Skin: Sensitive, Fair, Cool
Hair: Brown, Wavy, Fine
Eyes: Hazel
My hair feels amazingly soft after using a few drops of this stuff. Like..it feels better than if I used any leave in conditioner or serum. I'm so glad I don't have to spend money anymore on expensive products. It feels like I never even put dye on my head.
I also put this on my face at night. I'm still on the fence, cause I have combination skin that's sometimes oily sometimes super super dry. I've had some breakouts, but also have been using a few other new things on my face as well so it's too soon to tell...
Either way, this is awesome for your hair.
on 7/25/2013 4:46:00 AM
Age: 19-24
Skin: Combination, Fair, Not Sure
Hair: Brown, Other, Other
Eyes: Green
For many months I used coconut oil on every part of my body. Through the winter especially. Every single night. The result? Constantly peeling, dry lips. Flaking T-zone. Very dry skin everywhere. I'd wake up in the middle of the night with itchy dry-feeling feet.
A good way to moisturize is to wash, then apply moisturizer with real, natural ingredients like avocado oil, then apply a silicone/petrolatum ingredient over it after a minute to seal in the moisture. Petrolatum/silicones act as a barrier, helping prevent water from escaping, which is why you need to put it on skin/hair that is damp.
on 7/22/2013 4:14:00 PM
Age: 18 & Under
Skin: Sensitive, Fair-Medium, Warm
Hair: Blond, Other, Coarse
Eyes: Blue
I have naturally really dry hair and it doesn't help that I colour it and used heat constantly for years (I don't do it anymore)
I found on youtube a video, that showed how you can use this on your hair. I went out (to 3 grocery stores) looking after this and suddenly I found a jar. It was pretty expensive, but you really don't need much of this.
You apply some to the ends of the hair, before showering! Then you shampoo and condition as normal, and it should help your hair gets more moistruized and soft.
- i love this stuff. <3
on 7/22/2013 3:48:00 PM
Age: 19-24
Skin: Oily, Olive, Not Sure
Hair: Black, Curly, Fine
Eyes: Black
Coconut oil is one of the best (and most overlooked) beauty products available. And it's SO cheap! A jar of this baby can easily replace body lotion, deep conditioner, cuticle oil, eye makeup remover, stretch-mark cream, massage oil, hair serum, chap stick, after-shave lotion, dandruff treatment, tanning oil, exfoliator (when mixed with sugar), eye cream, hand cream, baby lotion, anti-aging facial moisturizer, shaving cream, and God only knows what else! I feel like no household is complete without a jar of coconut oil in the cupboard.
My personal favorite way to use this is as an intensive hair mask. After shampooing and conditioning as usual, I apply this from roots to tips (focusing on my brittle ends). After that I put my hair into a plastic shower cap and blow dry it through the cap for about ten minutes. Then I leave it to sit for two hours. After rinsing the oil out, my hair is RIDICULOUSLY soft and manageable. I have heard many people say that leaving it in overnight works even better, so I will try that and update with my results. No commercially available deep conditioner will repair your hair like coconut oil. The reason it is so effective is because it is one of the few oils that has been proven to penetrate the hair shaft and truly soften and repair damage. Just be warned, you have to rinse this out VERY good if you don`t want greasy hair after doing a treatment. If you plan to use this as a hydrating anti-frizz serum, use the TINIEST amount and focus on ends (I`d probably avoid roots all together). A little goes a LONG WAY!
I also love using this as a night cream after washing my face. A lot of people think that oils will break you out, but this does not (and I have oily, acne-prone skin). Massage it into your face at night, and you will wake up with smooth, GLOWING skin. I don`t suggest using this under makeup, since it IS an oil after all, and it will look greasy. It needs ample time to sink in. Now, this may just be my imagination, but I feel like my hyperpigmentation and acne scarring has been fading since I've started using coconut oil on my face. This makes sense since I did read somewhere that coconut oil is great for fading age spots and other blemishes.
This is also one of the best body moisturizers going. Apply it to even the driest skin, and it will instantly soften up. If you have dry hands, thickly apply coconut oil to them, then put on a pair of gloves for a few hours. When you remove them, you will have baby soft hands. The same goes for scaly elbows and knees. Heavily apply coconut oil, then cut the end off of an old pair of socks and put them on your elbows/knees. MAGIC. This is also great for helping to prevent stretch marks for pregnant women. Probably works better than any expensive cream on the market.
Finally, this is one of the best eye makeup removers available. I gently rub it onto my eyes, and even the toughest, most waterproof eye makeup vanishes. Plus, it also acts as an eye cream!
I could literally spend all day talking about the benefits (both beauty and health-wise) of coconut oil, but it's better if you just get a jar and try it! A large jar generally costs under $10 and lasts for quite a while. You can't go wrong!
10 out of 5!
BTW- If you have a Costco memebership, check there for coconut oil. They tend to sell it in larger quantities than you can buy at a grocery store, and for cheaper. I once saw it at $16 for 54 ounces!
on 7/20/2013 11:35:00 PM
Age: 18 & Under
Skin: Acne-prone, Fair, Cool
Hair: Blond, Straight, Fine
Eyes: Blue
Since there are three coconut oil review boards, I'll start with this: all the coconut oil I use is cold pressed, unrefined, extra virgin organic coconut oil. And I use it for my hair! My fine, easily damaged hair... and let me say, coconut oil works wonders for hair. I coat my hair in it every night, root to tip, and it feels so much softer and looks healthy/shiny when I wash it all out. You won't find a better deep conditioner than this, and it's unquestionably good for your hair. Coconut oil is one of the only oils proven to actually penetrate the hair shaft. When I use it, I coat my hands in oil and make sure to cover my hair with it- starting at the ends, and concentrating most of it there. Once I'm sure every strand is covered, I lay a small towel/sheet over my pillow and keep the oil on overnight (if you have longer hair, you may want to braid it). I don't only use it at night, though- I've also used it to protect my hair during swim practices, at the waterpark, on vacation (lots of UV ray exposure), and even at school... Although many people will attest to coconut oil's benefits for skin and acne, I actually find that it always causes acne at the hairline on my forehead, temples, etc. I don't mind much because acne at the hairline is hardly visible, but it is annoying and can be painful.
on 7/9/2013 6:50:00 AM
Age: 44-55
Skin: Other, Tan, Not Sure
Hair: Black, Other, Other
Eyes: Brown
Ok I admit that I have been such a fool. I lived in a tropical country in Asia where coconuts are a plenty. We used coconut milk for making curries and drink coconut water when the weather is scorching hot to dispel the heartiness in our bodies. I have always known the Indians love using coconut oil for their hair and they do have thick and lustrous hair. I am not going into giving reviews on the hair but my skin. I have tried using coconut oil for my face but it does not seem to be as effective as emu oil. However, for my whole body I slather a generous amount of coconut oil on my body twice a day and I have noticed after 2 weeks of application my skin seem to be smoother,brighter and even tone. But the best of all, my age spots are lightened as well. What a fool I have been...
Update: I have said earlier that I do not want to review coconut oil for hair but when I go through almost all the reviews I found that most use coconut oil on its own only. But now I would like to say that you can heat up some coconut oil in a saucepan and then stir in some hibiscus flowers and leaves or blue pea flower or curry leaves or mustard seeds or candlenuts or fenugreek seeds. So you have plenty of options and I have tried them all and I am pleased with the results. It leaves my hairs shiny and smooth but just a word of caution it can darken your hairs whereby some of you do want. Another thing please let the oil to cool down first before application and leave it on for at least an hour.
on 7/4/2013 6:28:00 AM
Age: 25-29
Skin: Dry, Fair, Not Sure
Hair: Black, Other, Other
Eyes: Black
I can't believe myself just find this gold mine (organic virgin coconut oil) now, what have I been missing out in the past 12 years? (I started buying expansive cosmetics since 18 now I'm 30) Honestly, 12 years of purchasing skin care from countless brands (high end to drug store) and spending lots of $$$, there hasn't been even one product that impressed me so much that I would keep repurchasing. I use it to replace my makeup remover, facial deep cleanser, eye cream, face, neck and body moisturiser, face and body scrub (with organic sugar), facial mask, hair mask, anti-frizze & anti split hair oil, hand and foot lotion, cuticle care, lip balm, eyelash serum, and honestly, it does a much better job comparing with each of the commercial product that I used. Just as a moisturiser for example, I wake up with the most glowing baby soft skin ever every morning since I started using it. It helps cleared out all the white heads (tiny little hard bumps) on my forehead (I also started using natural soap to wash my face), also the fine lines around my eyes and mouth, the scars from acne, the dry, flaky patches between my brows, around my nose and cheek bones, and the uneven skin tone from lack of sleep. I don't even have to say more to use it as all other things since it has been mentioned a million times on MUA lol. For 10 bucks I'm glowing head to toe, no kidding! If you haven't try this stuff, go try it now, If you have tried it and find it doesn't work for you, keep trying until it works! Your skin will never prefer those cancer causing chemicals over pure natural nutrients. Make sure you always use COLD PRESSED virgin coconut oil on your skin to get the most nutrients from it, and always apply immediately after washing your face or body for skin to fully absorb it, best to apply when the skin is still a little bit wet and always use a very small amount on your face (i.e. as long as your skin doesn't feel dry, that should be enough, if it feels greasy then it's way too much).
I also add a tea spoon to the milk with my cereal every morning, also my coffee and tea. It adds a heavenly delicious coconut scent, and it's extremely healthy. I also read online that it can help with weight lose by adding it to your daily diet. I'm now healthy inside, glowing head to toe out side that I keep get compliments on my skin, and have lots of money going to be saved up in my bank account from stop buying all kinds of cosmetics. Good bye all the expansive cancer causing chemicals, I will keep repurchasing this stuff for ever and ever and ever...
on 6/28/2013 9:07:00 PM
Age: 19-24
Skin: Acne-prone, Fair-Medium, Neutral
Hair: Brunette, Wavy, Medium
Eyes: Brown
Not a good idea if you're acne-prone. I did use it a lot back in my tanning days, but it never failed to break me out. My undereye concealer, highlighter, and one blush has this in it, but I haven't seen anything yet. I still would never put this on my skin as beautiful of a glow as it gives on people without acne-prone skin. I also don't care for soaps with this as a base because they disintegrate quickly and lather poorly.
on 6/25/2013 4:05:00 AM
Age: 19-24
Skin: Sensitive, Fair-Medium, Neutral
Hair: Brunette, Wavy, Medium
Eyes: Brown
I'm in love with coconut oil. I use it for everything.
One of my favorite uses is as a deep moisturizing treatment for my hair. I use it twice a week: the one day I do all hair including roots, the next time I just do middle/ends. I leave it over night and wash it off the next day. I use it with the DermOrganic products; shampoo, mascara and leave in treatment. It leaves my hair glowing and not in a bad way.
I also like to use it after waxing. When I'm done, I wash my hands and apply a bit of oil to my legs or wherever I just waxed. I get no red bumps and it also helps getting rid of tiny pieces of wax left behind. (I use Nair microwave wax without strips)
If I have no time to wax, and I have to shave, I rub the oil on my legs and jump in the shower. By using it before and after shaving I feel like my skin is "protected". (I hope this made sense to you). I get little razor bumps if I do it. It doesn't help with ingrowns, but it leaves you moisturized.
I also like to use it as a facial moisturizer. I usually put a bit on my face and under eyes and go to sleep. My skin looks really nice the next morning. (Or even use it under makeup during the winter).
I keep a tiny jar of coconut oil on the fridge, and another in the bathroom, as sometimes I cook with it (aka. coconut macaroons, granola bars...) and I don't want it all mixed.
I used to buy some of those expensive virgin coconut oil jars, but as I have to buy it often, I ended up trying the coconut oil that they sell in bulk at the Bulk Barn (they call it Organic Pure Virgin Coconut Oil). It works just as well and is cheaper.
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The picture shows a three-dimensional mesh computed from a thoracic CT scan. The red area depicts a pneumothorax, causing the lung to collapse, the green area shows a healthy lung.
The corresponding segmentation process is part of a project by Peter Salz, in cooperation with the Department of Anesthesiology and Intensive Care, University Hospital Leipzig (Prof. H. Wrigge, Dr. A. Reske).
Such meshes serve as anatomical models for Electrical Impedance Tomography image reconstruction. This functional imaging technique can be used to monitor mechanical ventilation of patients at the intensive care unit. With this work we hope to improve the medical expert's analysis and decision making during intensive care treatment.


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By Rebecca Lewis. CREATED Aug 18, 2014
Las Vegas, NV (KTNV) -- Police are on the scene of a rollover crash.
It happened around 12:17 p.m. on Monday near South Rampart Boulevard and Alta Drive.
Police say several cars were involved in the crash. One person was reportedly trapped inside the vehicle that was rolled over.
Eastbound lanes are blocked to clean up the glass. 3 victims were taken to the hospital by Las Vegas Fire and Rescue with non-life threatening issues. 2 of the 3 were from the rolled over vehicle.
Drivers are encouraged to avoid the area.
Action News will update this story once more information has been received.
- Latest


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Daily Sales Up to 50% OFF Limited-time deals start every day at 12 pm GMT.
Taylors Eye Witness have been making knives for over 150 years in its Sheffield factory and are the last remaining manufacturer of kitchen knives, scissors and pocket knives in Sheffield, the original city of steel.
On 1st June 2007 Harrison Fisher & Co Ltd changed it's name to Taylors Eye Witness Limited. The name makes life much simpler for customers as the company focuses on the development of the Taylors Eye Witness brand - high quality, well designed products from the cutting edge experts.
Taylors Eye Witness was founded by John Taylor in the early years of the 19th Century. The "Eye Witness" trademark was first registered in 1838. The inspiration for the choice of "Eye Witness" as a trade mark is believed to be Shakespeare's line in Henry IV - "No eye hath seen better".
Taylors Eye Witness products have stood the test of time through an unrelenting dedication to quality, service and good old fashioned technical know-how in the design and production of kitchen knives.


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World Fighting Championships - WFC March 15th, 2013 at Montbleu Resort, Lake Tahoe, Samuel Nolasco vs Johnny Crenshaw! Facebook.com/worldfightingchampionships watch video >>
OfficialXFC - The Next Generation of MMA The largest independent mixed martial arts promotion on television watch video >>
NAAFS Finish of the Week #83 Julian Lane Vs Crenshaw. watch video >>


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Hotel Rashmi
Hotel Rashmi started in 1990, has been a prominent budget hotel of the city. It is situated just a stone throw away from the famous Taj Mahal. The access to the hotel is very easy, either by road or by rail or bus. It is only five kms. from Agra Cantt railway station. In the close vicinity of Hotel Rashmi are top end multiplex Theatres, Shopping Malls, big departmental stores etc. Only five min. of walk from the hotel takes you to Taj Mahal, which is which is one of the seven wonders of the world. Agra Fort is also very near to the hotel. HOTEL RASHMI has been host to innumerable company officials and also to countless tourists.
Hotel Rashmi is a 3 floor property. Ground floor has reception, welcome area, private rooms. First floor has dorms and restaurant. Second floor is rooftop ideal to view Taj Mahal and yoga. An only 4 min walk brings you to the Taj Mahal and Taj Nature Walk, only 2 min from our hotel you can pass by the Taj Nature walk, a peaceful forest greenery, where you will see peacocks dancing, monkeys, donkeys, cows and horses. No need to pay extra money for a cap or rickshaw to go to the Taj Mahal. Enjoy this top location of our property, where you can easy access all the attractions here in Agra.
Our hotel is only 700 m away from the Taj Mahal, plenty of greenery, peaceful environment and only 2 min away from Taj Nature walk, racious surroundings of Peaceful Forest Greenery. The great location of our property offers you an easy access to any sights of Agra and of course it is the perfect location if you want to stay close to the Taj Mahal.
Disponibilidad y preciosPara ver la disponibilidad y los precios, selecciona las fechas y pincha "Actualizar fechas"
Instalaciones & Políticas de Albergue
- Recepción 24 horas
- Seguridad 24 horas
- Aire acondicionado
- Traslado al aeropuerto
- Alquiler de bicicletas
- Desayuno no incluido
- Televisión por cable
- Café
- Ventilador de techo
- Se aceptan niños
- La tarjeta de crédito no ha sido aceptada
- Tipo de cambio
- Mapas de la ciudad gratis
- Aparcamiento gratuito
- Wifi gratuito
- Limpieza
- Acceso a Internet
- Lavandería
- Guardaequipajes
- Sin límite de hora
- No fumadores
- Terraza al aire libre
- Aparcamiento
- Restaurante
- Mostrador de excursiones
Política de cancelaciónEsta propiedad cuenta con una política de cancelación de 1 días. Si no se realiza la cancelación dentro de ese plazo se aplicará un recargo de anulación igual a la primera noche de tu estancia.
IndicacionesMostrar mapaOcultar mapa
How to reach us from railway station:
take mall road and follow the signs to Taj Mahal via Fatehabad Road . turn left after Mc Dobald and continue for about 3 blocks and then take a left VIP Road and Eastern Gate of taj mahal . we are located one building before Taj Plaza Hotel . forth buiding before 5 star Hotel Amar villas
From Agra Cantt Railway Station:
Distance: 8 Km
Transportation: Taxi / Tuk Tuk
Price: INR 250 / 120
From Agra Fort Railway Station:
Distance: 5 Km
Transportation: Taxi / Tuk Tuk
Price: INR 200 / 100
From Bus stand
Distance 8 km
Transportation: Taxi / Tuk Tuk
Price: INR 200 / 100
From Airport
Distance 15 Km
Transportation: Taxi
Price: INR 400
At only 5 min walk brings you to the TAJ MAHAL, so no need to pay extra for a cab or rickshaw.


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Release date: March 3, 2005
Full Bloom: The Art and Life of Georgia O'Keeffe
Hunter Drohojowska-Philp, art critic, journalist, and author, Full Bloom: The Art and Life of Georgia O'Keeffe
Saturday, March 5, 2 p.m.
Phyllis Wattis Theater
O'Keeffe was one of the most celebrated artists of the twentieth century, but behind her bold work was a woman misunderstood by even her most ardent admirers. O'Keeffe biographer Drohojowska-Philp discusses a little-known but difficult period in the artist's life, the 1930s. A book signing follows in the Haas Atrium. In conjunction with the ongoing exhibition Matisse and Beyond: The Painting and Sculpture Collection.
$12 general; $8 SFMOMA members, students, and seniors.
Opening Day Program
Artist Talk: Gary Hill
Gary Hill, artist
Thursday, March 24, 6:30 p.m.
Phyllis Wattis Theater
Hill's video works engage viewers on multiple levels, presenting alluring visuals and sounds while manipulating the audience's sense of time and space. Hill discusses his interest in illusion and mitigated reality and reveals the techniques used to achieve his mesmerizing effects. In conjunction with the exhibition Image, Body, Text: Selected Works by Gary Hill, on view March 24 through May 30.
$12 general; $8 SFMOMA members, students, and seniors.
Art and Conversation
Martha Rosler: Art and Urban Space
Jill Dawsey, curatorial associate, painting and sculpture, SFMOMA
Friday, March 25, noon–1 p.m.
Koret Visitor Education Center
Conceptual artist Rosler uses video, photography, text, installation, and performance to investigate urban environments. Dawsey examines Rosler's interest in the city as a social space, with a focus on her video Secrets from the Street: No Disclosure, 1980, featuring San Francisco's Mission District. In conjunction with the ongoing exhibition Between Art and Life: The Contemporary Painting and Sculpture Collection.
Free with Museum admission.
Film Series: Jeremy Blake
In conjunction with the exhibition Jeremy Blake: Winchester, SFMOMA is pleased to present a special film series curated by artist Jeremy Blake with a screening each month from March through June.
McCabe and Mrs. Miller
By Robert Altman, 1971, 120 min.
Thursday, March 10, 7 p.m.
Phyllis Wattis Theater
In Altman's masterful anti-Western, individuality is expunged by the irrepressible power of mythic American iconography, also a concern in Blake's Winchester trilogy. Warren Beatty stars as an enterprising businessman who succumbs to a world of brothels, gambling, and gunslinging in the Wild West.
$12 general; $8 SFMOMA members, students, and seniors.
Hannie Caulder
By Burt Kennedy, 1971, 85 min.
Thursday, April 14, 7 p.m.
Phyllis Wattis Theater
Blake notes a parallel between the plight of rifle heiress Sarah Winchester and that of Hannie Caulder, both of whom struggle to rectify wrongs caused by gun violence. Raquel Welch stars in this revenge tale with a lighter side.
$12 general; $8 SFMOMA members, students, and seniors.
Art Sandwiched In
The Critic
Kenneth Baker, art critic, San Francisco Chronicle; David Littlejohn, independent journalist; Tessa DeCarlo, independent journalist; moderator: Neal Benezra, director, SFMOMA
Tuesday, April 19, noon–1:30 p.m.
The Schwab Room
What is the role of the critic in the arts community? What should it be? This group of esteemed arts writers examines the degree to which critics influence what we see in galleries and museums.
$60 general; $55 SFMOMA members. Includes lunch. To purchase tickets, call the Modern Art Council at 415.357.4090.
Presented by the Modern Art Council, an auxiliary of SFMOMA.
Artist Talk: Marilyn Minter
Marilyn Minter, artist; Joshua Shirkey, curatorial associate, painting and sculpture, SFMOMA
Thursday, April 21, 6:30 p.m.
Phyllis Wattis Theater
By exaggerating the conventions of fashion advertising, Minter's paintings and photographs expose the seduction as well as the underside of glamour. Minter and Shirkey talk about the evolution of the artist's work since 1969, discussing the way her recent images tap into deep-seated cultural anxieties about desire, beauty, and the body. In conjunction with the exhibition New Work: Marilyn Minter, on view April 1 through July 24.
Free with Museum admission.
Art and Conversation
Van Deren Coke: Collecting 20th-Century Photography
Erin Garcia, curatorial associate, photography, SFMOMA
Friday, April 29, noon–1 p.m.
Koret Visitor Education Center
The current installation of Picturing Modernity highlights photographs amassed during Van Deren Coke's eight-year tenure as SFMOMA's director of photography (1979–87). Garcia examines selected photographs illustrating Coke's interests in Surrealism, photographic experimentation, and the emerging artists of his day.
Free with Museum admission.
Phyllis Wattis Distinguished Lecture Series
Founded in 1995 through the generosity of Phyllis Wattis, this annual lecture series brings influential artists and thinkers to SFMOMA. This year's distinguished lecturer is art critic and author Peter Schjeldahl, widely known for his writing in The New Yorker as well as The Village Voice, The New York Times, and ArtNews.
The Story of the Image
Peter Schjeldahl
Thursday, April 7
Reception: 6 p.m., The Schwab Room
Lecture: 7 p.m., Phyllis Wattis Theater
In 1981, Schjeldahl wrote, "[Robert] Bechtle's realism is symbolically vibrant. It makes a symbolic connection between the completely seen and the completely known." In conjunction with the exhibition Robert Bechtle: A Retrospective, on view through June 5, Schjeldahl uses Bechtle's photorealist paintings as a starting point for exploring the narrative aspect of painting and its peculiar interplay with photography.
$15 general; $10 SFMOMA members, students, and seniors. Includes reception.
A Conversation with Peter Schjeldahl
Peter Schjeldahl; Neal Benezra, director, SFMOMA; Janet Bishop, curator of painting and sculpture, SFMOMA
Friday, April 8, 3 p.m.
Phyllis Wattis Theater
Benezra and Bishop engage Schjeldahl in a wide-ranging discussion of photorealism and its role in the creation of contemporary art. A question-and-answer period with the audience follows the dialogue.
Free with Museum admission.
San Francisco Museum of Modern Art
151 Third Street
San Francisco, CA 94103
Founded in 1935 as the first West Coast museum devoted to modern and contemporary art, SFMOMA is currently undergoing a major expansion project that will significantly enhance gallery, education, and public spaces, enabling the museum to better showcase more of its expanded permanent collection. While the museum is temporarily closed for construction, through 2016, SFMOMA is "on the go" with an extensive array of off-site programming across the Bay Area, including collaborative and traveling museum exhibitions, major outdoor projects and commissioned installations, and new education initiatives.
Visit sfmoma.org or call 415.357.4000 for more information.