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For those of you that have just read the title of this article and thought to yourself "never" – hopefully I am able to provide a little more detail to the debate than that.
But first, a question or two: are you an individual that bounces out of bed when your alarm clock sounds and heads straight for the gym, using exercise as a way to start your day? Or do you prefer to complete your day at work before attending the gym on the way home, using exercise as a means of unwinding after a long, demanding day at the office?
This debate has been ongoing for a lengthy period of time and there are arguments both for and against optimal training times. This article aims to consider some of the research regarding this topic to see if a definitive answer can be found, so that for those of you that are lucky enough to be able to pick and choose when you workout, you can optimise your gains.
The Optimal Time To Exercise
So what does research into this topic suggest? Investigations monitoring numerous bodily and exercise variables have provided results detailing the best time to exercise falls between 4-6pm.
During this time period, research has shown that an individual's internal mechanisms such as bodily circadian rhythms, lung functioning, hormonal and temperature levels to name but a few are all at their optimum. This in turn allows the following to be achieved:
- Increments in strength and anaerobic performance by up to 5%.
- Increments in endurance performance by up to 4%.
A reduction in the potential of sustaining a musculoskeletal injury when comparisons are drawn against morning training sessions has also been hypothesised. The reasons for this are that muscular temperature, flexibility and strength are all considered optimal during this time frame, therefore significantly reducing the potential for injury.
Adjusting Your Body Clock
As previously mentioned, it is important to recognise that many individuals, including myself, are often restricted in terms of when they can actually exercise. Although research does suggest an optimal training time, due to either work, family or social life commitments, this time period is simply not suitable.
Does this mean that exercising at any other time outside of the optimal training times will ultimately result in lacklustre sessions filled with doom and gloom? The answer, of course, is not at all! Research is obviously hypothesising that numerous training benefits can be achieved by exercising in the afternoon.
However, for those individuals who simply cannot train during these time intervals, you will be happy to know that further research has also shown that an individual's bodily circadian rhythms, which ultimately determine body temperature, hormonal levels etc can be adjusted and reset over a period of time.
So although afternoon training may be optimal, in theory, if you get into a set schedule and routine with your eating, training and sleeping patterns then you can shift your body clock accordingly to suit your needs and still achieve optimal results at different times of the day.
Final Word
If you are able to workout in the afternoon but have been training haphazardly at random times for whatever reason, it is potentially worth altering your training times to see if you can achieve further gains during the stated optimal training time.
However, if your work, family and social life often dictate when you can and cannot complete exercise, the next best thing is to create a stable schedule and routine where your eating, training and sleeping patterns remain consistent throughout.
After all, if we all trained at the gym between 4-6pm, it would be an absolute nightmare to park in the car park, let alone get on the equipment.
Now it is time for your view:
- Do you have set training times and routines/splits that you stick to like clockwork each week?
- Have you noticed a difference in energy levels, strength and the like between morning and afternoon training?
- Do you prefer morning or afternoon training sessions?
- How do you counteract the effect of a busy lifestyle on your training times?
Let us know in the comments section below…


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Happy Holidays from everyone at the Interweave Sudbury Office (a division of F+W Media): Quilting Arts, Cloth Paper Scissors, Stitch, Studios, Quilting Daily, Cloth Paper Scissors Today, and Sew Daily! Click on the link and watch the animation!
Loved it! You all are so cute! Happy Holidays to all of you, too!!!
Cute! and such perky music. Yay! Happy Holidays!
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Comparison of Central and Peripheral Venous Catheters
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The purpose of this study is to compare the mechanical and infectious complications of peripheral versus central venous catheters in critically ill patients. Group allocation will be performed by randomization.
Respiratory Insufficiency
Device: catheters
|Study Type:
|Study Design:
|Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Prevention
|Official Title:
|Randomized Controlled Trial of Mechanical and Infectious Complications of Central Versus Peripheral Venous Catheters in ICU Patients
- failure to insert line
- mechanical complications of intravenous line insertion
- infectious complications of intravenous lines
- number of cross-overs (due to impossibility of inserting/maintaining a peripheral line)
|Estimated Enrollment:
|Study Start Date:
|April 2004
|Estimated Study Completion Date:
|October 2005
Critically ill patients require intravenous administration of fluids and drugs. This can be achieved via peripheral or central catheters. Each device is associated with both mechanical and infectious complications. Complications associated with central lines are judged to be more severe. Some patients actually require the insertion of a central line due to the venous toxicity of the drugs or to the necessity of making sure that the infusion is regularly administered (example: high dose catecholamine infusion). Some physicians believe that most Intensive Care Unit (ICU) patients should have a central venous line inserted, whereas others feel that some patients may receive active drugs via a peripheral line in selected instances. No study prospectively compared the feasibility, merits and complications of the two possibilities (i.e., central or peripheral venous line). This study includes patients that can receive either a central or a peripheral line (see inclusion criteria): mainly patients receiving large amounts of fluid, moderate doses of catecholamines or of drugs that may cause venous injury. Patients are randomized to receive either a peripheral or a central venous catheter. Endpoints are the rate of mechanical complications (difficulty in inserting the line, need for repeat insertion attempts, occurrence of arterial puncture, occurrence of pneumothorax) and of infectious complications (local catheter infection or catheter-related bloodstream infection).
|Ages Eligible for Study:
|18 Years and older
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Patients requiring low to moderate doses of continuous catecholamine administration in the ICU
- Patients with 2 failed attempts at inserting a peripheral line
- Patients who require daily change of lines
Exclusion Criteria:
- Patients aged less than 18 years
- Pregnancy
- Absolute necessity of central venous access (refractory shock/high dose catecholamine infusion)
Please refer to this study by its ClinicalTrials.gov identifier: NCT00122707
|Service de Réanimation, Hopital Louis Mourier
|Colombes, France, 92700
|Principal Investigator:
|Jean-Damien Ricard, MD
|Assistance Publique - Hôpitaux de Paris
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|ClinicalTrials.gov Identifier:
|NCT00122707 History of Changes
|Other Study ID Numbers:
|Study First Received:
|July 19, 2005
|Last Updated:
|March 21, 2006
|Health Authority:
|France: Ministry of Health
Keywords provided by Assistance Publique - Hôpitaux de Paris:
catheter-related infection
mechanical complications of catheters
Additional relevant MeSH terms:
Pulmonary Valve Insufficiency
Respiratory Insufficiency
Cardiovascular Diseases
Heart Diseases
Heart Valve Diseases
Respiration Disorders
Respiratory Tract Diseases
ClinicalTrials.gov processed this record on October 02, 2015


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Dec. 7, not Tuesday, is D-Day for Medicare beneficiaries
Licensed independent insurance agent Linda Clure cautions beneficiaries to consider more than monthly premiums when choosing drug and health plans.
"You need to think about the maximum out-of-pocket, and whether you've got that amount set aside for emergencies," Clure said. "Meanwhile, some drug plans require greater physician involvement than others, and you may not want that hassle."
While consumers grapple with election choices for next year's plans, industry observers can't help but look to Tuesday's election.
To control rising Medicare costs, President Barack Obama's health reform plan, among other things, calls for cutting federal subsidies to Medicare Advantage plans, which have proved significantly more costly than original Medicare. Meanwhile Gov. Mitt Romney wants to give future beneficiaries — people now 54 and younger — federal vouchers to help buy insurance from traditional Medicare programs or competing private health plans when they become eligible.
Studies indicate the uncertainty of the future of health care, and reduced Medicare reimbursement payments, may be causing many doctors to opt out of Medicare or quit seeing new Medicare patients. Only half of doctors will continue their current practice during the next three years, according to a survey of nearly 14,000 doctors released in September by the Physicians Foundation.
Many respondents told Merritt Hawkins & Associates, a doctor recruiting firm, they plan to cut back on hours (22 percent), retire (13.4 percent), seek hospital employment (5.6 percent), transition to a cash/concierge model (6.8 percent) or close their practices to new patients (4 percent).
In Oklahoma, few physicians — 99 — have opted out of Medicare, according to the website of Trailblazer Health Enterprises LLC, which currently administers Medicare payments for state doctors.
"It's hard for physicians in rural Oklahoma, in particular, to stop seeing Medicare patients because seniors represent their patient base," said Melissa Johnson, director of health care policy for the Oklahoma State Medical Association (OSMA).
Oklahoma physicians, Johnson said, are concerned with what they view as an inevitable lack of access to health care as the U.S. population ages and 30 million more people are added to insurance rolls under health care reform.
Oklahoma is short about 400 family physicians alone, the OSMA told The Oklahoman after health reform passed in March 2010. And Bloomberg recently reported the current doctor shortage across all disciplines is some 13,000 and is expected to balloon to 10 times that number by 2024.
As for Ada endocrinologist Curtis Harris, he opted out of Medicare 13 years ago.
"I was being reimbursed some 80 percent of my overhead, excluding wages, and nowhere close to my time," Harris said. "I was not only not making any take-home, but losing money and had to charge others more."
The cost of billing Medicare alone cost him $24 to $30 a bill, he said.
Still, he lost only two patients in the transition, Harris said.
"Once they realized they could continue to use Medicare for hospitalizations and labs, and wouldn't be stuck with huge hospital bills, they were fine," Harris said.
Today, his costs billed to patients are $500 a year at most, Harris said.
"Try to get that kind of specialty care for much less, even if you have insurance," he said.
Medicare election period closing
• For free counseling to make sure you're on the right plan, call the Medicare Assistance Program at the Oklahoma Insurance Department at (800) 763-2828, from 8 a.m. to 5 p.m. weekdays. Counselors can answer questions or set appointments for their office at 3625 NW 56, Suite 100. If you live outside the metro area and you'd like free face-to-face counseling in your local area, Medicare Assistance counselors can connect you to a qualified agency such as the Area Agencies on Aging or the Community Action Agencies.


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Heartsmile: PBS remixes Mister Rogers.
"Did you ever grow anything in the garden of your mind. You can think about things and make believe. All you have to do is think, and they'll grow."
With thanks for the tip to Reddit: "PBS discovers Symphony of Science on YouTube, commissions a remix of Mister Rogers. It got to me a bit."
Mister Rogers Remixed | Garden of Your Mind | PBS:
Mister Rogers remixed by Symphony of Science's John Boswell for PBS Digital Studios.
When we discovered video mash-up artist John D. Boswell, aka melodysheep, on YouTube, we immediately wanted to work together. Turns out that he is a huge Mister Rogers Neighborhood fan, and was thrilled at the chance to pay tribute to one of our heroes. Both PBS and the Fred Rogers Company hope you like John's celebration of Fred Rogers' message. (Headphones highly recommended!)
This is the first in a series of PBS icons remixed.
Many thanks to the folks at the Fred Rogers Company for their support.
More from melodysheep: http://www.youtube.com/melodysheep
Subscribe to PBS Digital Studios: http://www.youtube.com/pbsdigitalstudios
On Twitter: @pbsds
More wonderfulness:
"So many people have helped me to come here to this night. Some of you are here, some are far away and some are even in Heaven. All of us have special ones who loved us into being.
Would you just take, along with me, 10 seconds to think of the people who have helped you become who you are, those who cared about you and wanted what was best for you in life. 10 seconds, I'll watch the time. Whomever you've been thinking about, how pleased they must be to know the difference you feel they have made. You know they're kind of people television does well to offer our world.
Special thanks to my family, my friends, and my co-workers in Public Broadcasting and Family Communications, and to this Academy for encouraging me, allowing me, all these years to be your neighbor. May God be with you. Thank you very much."
Bonus reminder via a Redditor, link to our Allie's article: "If you've never seen the video of Mr. Rogers defending children's programming on the floor of the senate, you need to. Here's a link.
Listen closely to the tone of the congressman change over the course of 6 minutes. He was an amazing man."
On another note…
Incorrect source, offensive, or found a typo? Email us (please put title in subject bar of email so we'll be able to fix). Or do you want to write for Elephant?
{Waylon H. Lewis C Enterprises 2015: Use Rights in perpetuity. Ownership remains with author.}
4 Responses to "Heartsmile: PBS remixes Mister Rogers."
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[…] Mr. Rogers, Bob Ross was my favorite PBS […]
This is so beautiful – the Garden of Your Mind song made me cry so many tears of gratitude for this wonderful man's life and impact…brought back many childhood memories.
Thank you very much for sharing.


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Find the Perfect Pair of Jeans in Three Easy Steps Jaclyn Johnson is an LA-based blogger who turned her hobby into a full-blown career. Her love of fashion and trends led her to create SomeNotesOnNapkins.com, and she hasn't looked back since. With a hectic, fast-paced schedule, Jaclyn relies on jeans to polish off her look, all the while keeping her stylish and comfortable. Check out Jaclyn's story in this video and learn more about Levi's® Curve ID.
popsugar / with /


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Smack dab in the middle of things in the nation's capital, The Madison is perfectly located on M Street, just a short walk from the White House, Mall, Dupont Circle boutiques, and countless museums. A blend of sophisticated, urban luxury and historic tradition, this landmark hotel has hosted every president since John F. Kennedy. The 353 recently-renovated guest rooms and 42 suites pamper guests with plush furnishings and amenities, and the service—as to be expected of a place that has hosted heads of state, international business leaders, and Washington's most notable figures—is fine-tuned, personalized, and genuinely warm. Until February 28, 2007, The Madison is offering guests an upgrade to a luxurious suite for $60 during weekend stays. (Standard room rates start at $159 per night.) Furthermore, if you book your reservation with Five Star Alliance, you'll receive a welcome amenity and possible one category room upgrade based upon availability at check-in.
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|Product #: EMC0799026_TQ
A Story-Writing Center: Story Prompts (Resource Book Only) eBookGrade 1|Grade 2|Grade 3
Ships Free!
Please Note: This ebook is a digital download, NOT a physical product. After purchase, you will be provided a one time link to download ebooks to your computer. Orders paid by PayPal require up to 8 business hours to verify payment and release electronic media. For immediate downloads, payment with credit card is required.
This unit provides directions and story prompts for teachers to create a story-writing center for the classroom. Students select a story prompt card and write a story. (Find other units by searching 'Write a Story 1-3')
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[...] showing off her gorgeous glowing skin. Want to take your ponytail to the next level? Check out this post from Gloss Daily, where we show you how to style the perfect high ponytail with help from a star [...]
Hair How To with Tommy Bucket and Garnier: The Perfect High Ponytail
As we mentioned in our trend forecasting from NYFW, ponytails are going to be big this fall. High, low, sleek, and messy–the whole gang's coming to a pinterest boards and fashionable heads of hair near you! While most of us mastered a basic pony in grade school, it can be tough to get that oh-so-sleek style that we loved during NYFW. For help on that front we turned to Tommy Buckett, hairstylist extraordinaire at the Serge Normant Salon. This season he crafted incredibly chic, "uptown" ponytails in partnership with Garnier for the Kate Spade Fall/Winter 2014 presentation at Fashion Week.
The key product behind the look was Garnier Marvelous Oil Deep Nourish. We watched it completely knock out any frizz in the models' hair and create gorgeous shine, too. "A lot of people are scared of oils but this is actually really light and it sinks into the hair because it has no silicone," Buckett explained about the Nourish oil.
Here's how to get the look:
1. Begin by blow drying your hair straight. Once the hair is dry apply 4-5 pumps (for long hair, less for short) of Garnier's Marvelous Oil Deep Nourish. You can also apply a little heat protecting spray.
2. Use a flat iron to smooth out your hair so it is as straight as possible to get a sleek look.
3. Flip your head upside down so your hair hangs down over your face. Gather it together in one hand, smoothing with a brush as needed.
4. Holding onto your ponytail, flip your head back upright.
5. Tilt your chin up and look at the ceiling while keeping your ponytail as tight as possible. This is Buckett's trick to get the tightest possible ponytail.
6. While your chin is still tilted up, secure your ponytail by wrapping it with a hair bungee--this type of hair tie will keep the ponytail as tight as possible without creasing the hair.
7. Use Garnier Disorder wax spray to smooth any flyaways or baby hairs.
8. Wrap a strip of leather over the elastic and secure it.
2 Comments + Add Comment
An outstanding share! I have just forwarded this onto a colleague who had
been conducting a little research on this. And he in fact bought me lunch
simply because I discovered it for him… lol. So allow me to reword
this…. Thanks for the meal!! But yeah, thanks for spending the
time to talk about this topic here on your blog.


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Scanning 101: Scanning Services
One major advantage of digital photography is that, unlike film photography, images can easily be stored in multiple locations for safe-keeping. You can protect your one-of-a-kind film prints in the same way by scanning them into a digital format and storing them on CDs or DVDs at a second location (see "Tech Tip: Scanning 101" in the March/April 2009 issue of Simple Scrapbooks magazine).If you don't have time to scan them yourself, you can hire a professional scanning service to do it for you. Before you trust your photos to strangers, be sure to research your options and find a service that fits your individual needs. There are many scanning services out there, so to help you get started, we've compiled brief comparisons of four popular scanning services. For more comprehensive information about these services, visit their websites.
• Scans all photo prints at 600 dpi.
• Includes free dust/scratch removal, red-eye removal, cropping, rotating, and manual color correction.
• Will organize scanned images into an unlimited number of folders according to labels provided by you (optional).
• Posts scanned images online for you to review.
• Allows you to delete up to 50% of scanned images before paying.
• Returns scanned images as JPEGs on CD or DVD (price of media included in scanning fee).
• Price: $0.27 per photo print at 600 dpi.
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A great smile and dressed for the office
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Play our fun game and find out if the one you like likes you back. Confide in us if you think you'd hit it off by clicking: Yes, No, or Maybe. We'll anonymously find out and let you know if the feeling is mutual. You have nothing to lose!
You've already said YES! If the feeling is mutual, we'll let you both know.
You've already said No. If you've changed your mind, let us know. If you say Yes, we'll anonymously find out if the feeling is mutual. You have nothing to lose!
You've already said Maybe. If you've changed your mind, let us know. If you say Yes, we'll anonymously find out if the feeling is mutual. You have nothing to lose!
You both said YES! The feeling is mutual. Now the rest is up to you! Say Hi and get the conversation started.
Life is so much better when shared. My cup is almost full, but it will be overflowing if I meet the right woman to share life's adventures. I want to live with/marry someone I don't wish to live without. Someone who is both a friend and a lover who feels she can confide in me and depend on me and visa versa. I am family oriented. I like movies, concerts, walks, and public displays of affection. I communicate well and I am a good listener. I enjoy time with friends and family, watching sports and the news (I am not a sports junkie.) I am a real mensch! Trustworthy, charitable, a man with true integrity and I do what I say I will do. I believe that fun/humor is an important part of what keeps us sane. For those who care, I like the Yankees and NY Giants. I also enjoy college basketball, especially during March Madness. I am a Sunday morning news junkie, but it never stops me from attending a family function or doing other things. I just like to keep informed. I am not afraid of commitment. I am also not afraid to admit when I am wrong. Unlike other males, I used to ask for directions, but with GPS it is no longer necessary. . My siblings and mother all live within 6 miles. My son has chosen to live with me because he knows I am there when he needs me. We go our separate ways, but we sit down for Shabbat dinner most weeks.
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Spark Networks USA, LLC does not conduct background checks on the members or subscribers of this website. However, the safety and security of our members is our top priority. We urge all members to follow our online safety tips.
The Color Code icon tells you that this member has taken the FREE Color Code Personality Test and wants to share his/her results with you. You can read all about their Color Code profile on the new Color Code tab.
The Color Code, by Dr. Taylor Hartman, is one of the most insightful personality tests in existence, and is made up of four personality Colors, or driving Core Motives. The Color Code teaches you the real motives behind your actions and how to better relate to other personality types.
Don't miss this chance to get valuable, life-changing personal insight, it only takes less than 15 minutes and it's FREE!
Want to read more about this member's color code?
Read more now
Any woman who has more than one child can tell you how different each child is from birth. You are born with your personality intact. The Color Code is based on your natural, innate personality type. Of course, people may change over time, but your Core Color will always remain the same.
Sometimes it is difficult to choose from the four options given, but there is usually one that fits better than the rest, or at least one that you could see yourself as more so than the others. If you're still unsure, try asking someone who knows you well, such as a parent or sibling. They can give clarity on areas of your personality that you may not notice.


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The Cambridge Centre for Proteomics (CCP) is comprised of three sections, a research group that specialises in quantitative and spatial proteomics, and a core facility that provides facilities for the School of the Biological Sciences and for wider collaborators in Cambridge and the UK and the Computational Proteomics Unit (CPU). CCP offers a fee for service proteomics resource and is part of PrimeXS, a pan-European FP7 funded proteomics consortium involved in platform development and transnational access.
We are interested in the development of technologies which enable measurement of the dynamics of the proteome in a high throughput manner in space and time during cellular processes such as signalling and differentiation.
1. Localisation of Organelle Proteins using Isotope Tagging (LOPIT) (1), which allows the assignment of proteins and protein complexes to sub-cellular locations, has been applied successfully to several biological systems (2,3). The ability to assign individual proteins accurately to specific sub-cellular structures and monitor their movement within cells is of paramount importance to our understanding of cellular mechanisms. High resolution cellular mapping using hyperplexed quantitative proteomics methods, hyperLOPIT, are being developed in collaboration with Martinez Arias (Genetics) and applied to various projects including the Evan, Oliver and Ralser groups (Biochemistry).
2. Protein protein interaction methods. These include: i.Interactomes using Parallel Affinity Capture (iPAC) is a method developed in collaboration with the St Johnston (Gurdon Institute) and Russell (Genetics Dept.) groups to determine genuine residents of multi protein complexes (4).
ii. Selective Proteomic ProximityLabeling using Tyramide (SPPLAT). Developed in collaboration with the A. Jackson (Biochemistry) and Sarah Perrett (University of Chinese Academy of Sciences), this method enables the identification of proteins in the immediate vicinity of a target membrane protein (5).
3. DDIP - Drosophila developmental interactome project
We have recently embarked on a large study across the Lilley, Russell (Genetics) and Martinez Arias (Genetics) groups in Cambridge and colleagues at the University of Manchester (Hubbard and Bergman) and University College London (Jones and Orengo), to map the alternatively spliced proteome during the early stages of Drosophila development in a quantitative manner, and to look at its impact on protein protein interactions, sub cellular localization and protein structure, with emphasis on components of major signaling pathway proteins. This study is funded by a BBSRC sLoLa.
4. Development of quantitative proteomics workflows involving label free methods (6) and isobaric tagging. (7)
5. Robust statistical and computational data analysis is of vital importance to the above techniques, and to proteomics in general, to ensure that data sets are efficiently mined and do not contain unacceptable levels of false discovery. CPU comprises a dedicated team of informaticians to develop bioinformatics and statistical tools, that utilize pattern recognition and machine learning methods to enable robust analysis of organelle proteomics and multi-protein complex data (8). The output of this research is manifested in the creation of open-source software solutions for quantitative data analysis that are applicable to the majority of quantitative proteomics applications (9).
Lab members: Andy Christoforou, Michael Deery (Core lab manager), Renata Feret, Laurent Gatto (director of CPU), Arnoud Groen, Adam Guterres, Julie Howard, Kathryn Lilley (Director of CCP), Claire Mulvey, Isabelle Nett, Daniel Nightingale, Nino Nikolovski, Konstanze Schott (Pathology) Lisa Simpson (CPU), Pavel Shliaha, Houjiang Zhang, Hongtao Zhou (Rothamstead)
Visit Cambridge Proteomics Centre website
Key publications:
1. Dunkley TPJ, et al (2006) Mapping the Arabisopsis organelle proteome. Proc. Natl Acad. Sci. 103 (17): 6518-6523
2. Hall SL, et al (2009) The organelle proteome of the DT40 Lymphocyte cell line. Mol Cell Proteomics. 8(6):1295-305
3. Groen AJ et al, (2014) Identification of trans-golgi network proteins in Arabidopsis thaliana root tissue. J. Prot. Res 13(2):763-76
4. Rees JS, et al (2011) In vivo analysis of proteomes and interactomes using parallel affinity capture (iPAC) coupled to mass spectrometry. Mol Cell Proteomics. 10 (6) M110--002386
5. Li XW, et al (2014) New insights into the DT40 B-Cell Receptor cluster using a proteomics proximity labelling assay. J. Biol. Chem. in press
6. Bond NJ, et al (2013) Improving qualitative and quantitative performance for MS(E)-based-label-free proteomics. J. Prot Res. 12(6):2340-53.
7. Shliaha PV, et al (2014) Additional precursor purification in isobaric mass tagging experiments by travelling wave ion mobility separation (TWIMS). J. Prot. Res. in press
8. Breckels LM, et al (2013) The effect of organelle discovery upon sub-cellular protein localization. J. Prot. 88:129-40
9. Gatto L, et al (2014) Mass-spectrometry based spatial proteomics data analysis using pRoloc and pRoloc data. Bioinformatics. 30 (9) 1322-4


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Now more than ever, there's a magnifying glass over luxury purveyors and the way they treat employees, and even more so, their customers. First it was Barney's, who came under fire after two young African Americans accused the high-end department store of racial profiling, then an HBO actor held Macy's responsible for a similar case of social injustice.
In addition to racial prejudice, there's another kind of bias that's also been commonplace in the retail arena — and that's judging someone based on their appearance (i.e. clothing, age, etc.). Perhaps you've been in this situation yourself, where you're blithely perusing the displays at Louis Vuitton or Prada, not exactly looking you're most fancy, and get the eery feeling that the sales associates who greeted you with fake smiles are sizing you up as a window shopper. For those that have experienced this, or just big spenders cloaked in a sweatpants guise, it appears the worst of those judgement days may be over thanks to an uptick in stealth wealth.
According to the Financial Times, new academic research suggests that luxury stores have learned the age-old adage of 'don't judge a book by its cover'. Harvard Business School surveyed shop assistants from luxury boutiques in Milan to assess how they would react to a customer dressed in gym clothes or flip-flops and a Swatch. Interestingly enough, the study found that the sales people were more likely to view the person as a potential celebrity compared to a similar woman wearing an elegant dress or a Rolex.
"Wealthy people sometimes dress very badly to demonstrate superiority," said one of the assistants. "If you dare enter these boutiques so underdressed, you are definitely going to buy something."
The authors of the study argue that the key finding of this study is that luxury markets are looking to understand how non-conformist consumers signal that they're making a deliberate choice not to get dressed up versus a lack of disposable income.
Considering that we always got a bad feeling in the pit of our stomachs during that infamous shopping scene in Pretty Woman, in which Vivian (a.k.a. Julia Roberts) is treated hideously by the salespeople at a Beverly Hills boutique based on her racy get-up, we're happy to learn that employees are seemingly making less snap judgements.
Related Links:
Barneys Apologizes After Claims of Racial Profiling
Another Black Shopper Arrested for Splurging at Barneys
Shop and Frisk? Barneys Shopper Arrested for Being Black [Updated]


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A senior at an elite college, already under severe pressure to complete her thesis and land a prestigious job, must confront the sudden reappearance of her old boyfriend, after his two year, unexplained absence...report summary
Catherine Burke is under pressure. She faces exams, completion of her thesis, and a competitive interview process, all of which is compounded when a police detective, Wade Handler, begins investigating the two year-old disappearance of her boyfriend, Embry Langan, a young man whose memory haunts and obsesses her. As the investigation continues, Catherine is forced to choose between her past passions and new possibilities, even as Handler is discovering surprising new facts about Embry and his possible connection to another disappearance from campus.
Written by 5fingerdis63.43K


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This headphone amplifier use 6N2 as preamplifier and 6N1 as output transformer driver. It can drive headphone from 32Ω to 600Ω. This HP amplifier has very nice sound quality if well built. Special care must be taken on grounding to avoid hum.
we will take photos to prove our goods are good quality before sending, as you know, because of violent conveyance, we can not make sure the goods are still in good condition when you receiving. So pls check the goods when you sign it.
· Pure tube design
· 6N2 as preamplifier
· 6N1 as output driver
· 6Z5P as rectifier
· 99dB SNR
· Max 500mW power
· Freq response: 10Hz-30kHz ±1dB
· Dimension: 320mm x 170mm x 130mm
· 2 groups RCA as input
· 1 pair RCA as preamplifier output
· 6.3mm headphone jack
· Stainless steel chasis
· Transformer output, protect your headphone
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Tactical Ripstop Pant - Dickies
Dickies Tactical Ripstop pant, engineered to work as hard as the officers who...
Its speed display is visible at 1,000 feet and the RT-50 meets the height requirements of the United States Department of Transportation (USDOT) for maximum safety and motorist visibility. The RT-50 operates for 14 days on a single charge of its existing battery system and will operate indefinitely using the optional solar charging system.
Request information about this product


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15 reviews
66% would repurchase
Package Quality: 3.8
Price: $$$
Package Quality: 3.8
Price: $$$
Not tested on animals
INGREDIENTSOrganic Ricinus Communis (Castor) Seed Oil**, Organic Simmondsia Chinensis (Jojoba) Seed Oil**, Organic Cera Alba (Beeswax)**, Silica*, Organic Argania Spinosa (Argan) Kernel Oil**, Organic Butyrospermum Parkii (Shea) Butter**, Euphorbia Cerifera (Candelilla) Wax*, Organic Copernicia Cerifera (Carnauba) Wax**, Tocopherol*, Natural Flavor*, Trans-Resveratrol*, Vitis Vinefera (Grapeseed) Oil*, Siraitia Grosvenori (Monk Fruit)*. May Contain: Mica (Ci 77019)*, Titanium Dioxide (Ci 77891)*, Iron Oxides (Ci 77491, Ci 77492, Ci 77499)*, Carmine (Ci 75470)*, Fd&C Blue No. 1 (Ci 42090), Fd&C Yellow No. 5 (Ci 19140), Fd&C Yellow No. 6 (Ci 15985), Fd&C Red No. 40 (Ci 16035), D&C Red 6 (Ci 15850), D&C Red 7 (Ci 15850), Manganese Violet (Ci 77742)*. *Natural. **Certified organic.
on 2/24/2015 4:46:00 PM
Age: 44-55
Skin: Combination, Fair, Cool
Hair: Brunette, Straight, Medium
Eyes: Grey
Did not care for.
The color is fine (if not accurate to it's description for me, read below), but this is very drying and was even hard to apply, it tugged on my lips terrible. I know matte lip products tend to be dry, but this one is especially dry to me, and for the price, no thank you. This color only lasted barely an hour on me, more like half-an-hour, and that was with no talking, no drinking or eating, nothing.
There are similar and even better and more affordable options out there, even the drugstore has far better options and at far better prices.
I know BITE is popular, but to me, this is a dud, a fail. Also when I look at swatches online of this shade, it looks nothing like the one I have, and yes I do indeed have this in Rhubarb, but it looks almost like a brick/burgundy on my lips, and my lips are not really pigmented at all, I am NC20. Online it is described as mauve, and this is not anywhere near a mauve on my lips. I wore this with no other lip product, nothing, just my bare lips.
The cap also was hard to remove at first and continued to be difficult to remove in ensuing applications - you have to really tug and then be careful as to not have the cap mess up the tip when pulled off, as you do have to tug a little...or a lot..
Tug, tug, tug, dry, dry, dry.
No, I would not purchase.
on 2/8/2015 12:06:00 PM
Age: 30-35
Skin: Normal, Fair, Neutral
Hair: Brunette, Wavy, Fine
Eyes: Brown
My skin tone: fair-light, N15/N15
Eyes/hair: medium brown
I LOVE this color. it might be one of my favorite lipsticks of the ~50 lip products I've owned or tried. For everyday wear, it's my favorite. It gives me a slightly darker than MLBB which is perfect - I want to look slightly but not overly made up, and this is enough to make my 31-year old self look slightly older but not toooooo overdone (which is a makeup concern of mine since I'm a prof at a community college!)
Texture & longevity:
I prefer the formula of these pencils over the lipsticks. Not too moist but not dry, either. Lasting power is phenomenal - these last on me as long as I'm not eating pizza. Even wear, easy to reapply (love how it's pencil). If I line &fill in my lips first I get something like 6 hours from these! Rhubarb is no exception. Blotting the 1st layer then a lightly applied second layer works wonders.
One beef of mine with the pencils is that the cap of the pencil gets totally messed up if you let it bounce around your purse for a while. Like the outer layer peels and it looks gross. Store carefully! The matte black material feels luxurious. These pencils are retractable which is handy and classy.
Cost: full size $24 at Sephora. Ouch :( I have the mini from a Christmas set but will definitely pick up the FS.
on 12/17/2014 8:54:00 PM
Age: 19-24
Skin: Dry, Medium, Warm
Hair: Black, Straight, Medium
Eyes: Brown
I had seen some talk about Rhubarb being a MLBB ("my lips but better") color for some people, and that might be stretching the definition a bit. I find it much more rosy than my natural lip color which is quite pigmented to begin with. It is a nice neutral rosy color in itself though.
The finish is natural instead of matte as there's a slight sheen, and this works well with my dry lips. It doesn't emphasize my lip lines and it's comfortable to wear. However, this comes with the tremendous trade off, that it doesn't last at all and is prone to transferring a bit too. I drink water and snack constantly so I prefer something with more lasting power, a lip product that is able to keep up with me for an hour at the least.
I also find the packaging to be more finicky than I would like. The cap needs to be placed on carefully or else the tip will smudge all over. After the tip (which comes "sharpened") has worn off, since this is a retractable twist-up, some of the precision the product first had when it was pointy has been lost.
While this is a nice enough color, the lasting power just isn't there. I gave mine away and don't plan on repurchasing more of these pencils (having also tried other colors and experiencing that the formula does not vary much between colors).
on 11/12/2014 12:58:00 PM
Age: 25-29
Skin: Combination, Olive, Not Sure
Hair: Other, Other, Other
Eyes: Brown
This does not last very long but the colour is amazing
on 11/10/2014 5:05:00 PM
Age: 44-55
Skin: Combination, Fair-Medium, Neutral
Hair: Blond, Straight, Fine
Eyes: Hazel
I received this as one of the holiday kits for 2014. There were 4 minis in the kit and this is one of them. A redish tone mauve very nice for everyday wear. I do not find them drying but creamy. staying power is pretty good and there is a stain but you do have to re apply after eating or drinking. This in my opinion is neutral and can be worn with just about any eye lip combo and not be overly strong. Not sure about all the other colors in the kit but this is definitely one I will replace this one.
on 10/29/2014 5:16:00 PM
Age: 30-35
Skin: Combination, Fair-Medium, Warm
Hair: Black, Wavy, Fine
Eyes: Brown
This is currently my favorite lip color. It's a mauvey rose, which reminds me of my favorite discontinued NARS lipstain, Sayonara. The pencil format makes it easy to apply and the formula is not nearly as dry as the matte pencils. I love the scent of Bite lipcolors and the fact that they use food grade ingredients. If only they lasted longer - I tend to get lip-ring with Bite products because they don't have much lasting power and wear off unevenly.
on 8/6/2014 1:13:00 PM
Age: 25-29
Skin: Combination, Medium, Warm
Hair: Brunette, Straight, Medium
Eyes: Brown
This has become my new lip obession. I first saw it during a trip to Sephora back in March and was already impressed by how creamy and pigmented the Bite Beauty pencils are, But, I passed on it thinking "Well, I have sooo many lip products". Fast forward to the middle of July, I was on the hunt for a lip product that i could just slide on my lips and go.
I love that this lines and gives your lips color all at the same time. Rhubarb is such a perfect rosy plum mauve and compliments sooo many skintones include my NC 35-37 Skin. I apply this and then follow with Whitening Lightining Gloss in Pouty Princess. such a nice natural rosy lip.
Also, if you're trying to get the SUPER RAVED about Kylie Jenner lip, this pencil will definitely give ya the desired look. Will defnitely repurchase when I'm out.
on 7/19/2014 11:07:00 PM
Age: 25-29
Skin: Combination, Olive, Warm
Hair: Brunette, Wavy, Medium
Eyes: Brown
I got this in the Best of Bite holiday set (2013) from Sephora. It was $29 for 4 mini versions(0.05g) of the high pigment lip pencils which is a pretty good value. This was my first encounter with the Bite Brand so I was really excited to try them out!
I ended up trying this shade first. My lips are pretty pigmented and dark so this shade was the perfect MLBB (my lips but better) shade and I ended up wearing this all winter. One swipe and your lips are ready to go! The colours are very creamy, smooth and soft. It's almost a little too soft and if you are too quick when applying it or a bit too heavy handed, it will end up bleeding over your lips.
That would have to be the only downfall. However, I experienced this only with the Rhubarb shade, the other ones I had no problems with bleeding. Hmmmmm...maybe it's because I used it more compared to the others?
I dunno, but I still love them! :)
on 12/6/2013 8:13:00 AM
Age: 30-35
Skin: Oily, Fair, Cool
Hair: Brunette, Curly, Fine
Eyes: Green
I got a travel size of this pencil in the four-piece Best Bite holiday set from Sephora. This is the first pencil from the set that I tried because I'm very drawn to berry shades on my NW20 skin. This is my first experience with Bite products and I am extremely impressed. The finish on these isn't matte, not matte like the NARS pencils are matte. These are very creamy, demi-matte and extremely comfortable to wear. I am so pleased with my purchase and will definitely be looking into the full sized pencils in the future. The travel pencils have .05 oz, which is a generous size considering that one layer will give you good coverage as these are very pigmented. Well worth the $25 price tag.
on 9/29/2013 4:58:00 PM
Age: 25-29
Skin: Combination, Fair, Not Sure
Hair: Brunette, Other, Other
Eyes: Blue
I was pleasantly surprised by this lipstick.
It looks quite dark, but it applies lightly, with a slight sheen. I definitely wouldn't classify this as a pure matte- more of a demi-matte.
However, it does not last very long. It seems to disappear soon after i put it on my lips, leaving my lips dry.
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Bocconcini Salad
- Active Time 10m
- Total Time 10m
Serves 4
Bite-sized balls of mozzarella, known as bocconcini, are ideal for making this colorful salad. Look for them in Italian delicatessens, or cut larger mozzarella balls into small chunks. If possible, seek out mozzarella di bufala, made from water buffalo's milk; a specialty of central and southern Italy, it is a softer, creamier mozzarella than that made from cow's milk.
- 1 pound mozzarella bocconcini
- 8 cherry tomatoes, cut in halves
- 1/2 cup diced green bell pepper
- 1/2 cup thickly sliced celery
- 1/2 cup thickly sliced Belgian endive
- 1/2 cup thickly sliced arugula
- 1 1/2 tablespoons fresh lemon juice
- 3 tablespoons extra-virgin olive oil
- Salt and freshly ground pepper
- 2 tablespoons fresh basil leaves or 1 tablespoon dried basil
In a large salad bowl, combine the mozzarella, cherry tomatoes, bell pepper, celery, endive and arugula.
Pour the lemon juice into a small bowl. Gradually add the olive oil, pouring it in a slow, steady stream and whisking constantly until emulsified.
Pour the mixture over the salad, and season to taste with salt and pepper. Toss until all the ingredients are thoroughly coated with the dressing.
Sprinkle the basil over the salad and serve immediately.
Recipe reprinted by permission of Weldon Owen. All rights reserved.
RecID 2146
nutrition information per serving
433 calories; 30g total fat; 61mg cholesterol; 622mg sodium; 8g carbohydrates; 2g fiber; 32g protein
These nutrition facts are calculated according to the ingredients listed in this recipe. Any substitutions will change these facts. Although we strive for accuracy, please note that food manufacturers occasionally change their food formulas, which could affect the calculations as shown.
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Hey everyone!
So I was wondering...what are your thoughts on going Trick-Or-Treating with horses?
It sounds fun. You can dress up yourself and your horse and hit the road for some candy!
But it also sounds dangerous. Little kids running around in crazy outfits out in the dark..something's gotta spook your horse if he/she isn't completley bombproof.
I was considering taking my paint. He is currently away in professional training to work out his little kinks. I was thinking I could be an indian and Sailor could be my indian pony.
His previous owner has taken him to several playdays and even a parade. If I felt he wouldn't be safe enough to ride, I could always lead him.
However, It's probably smarter to wait until next year. I haven't owned him long and Sailor probably isn't quite up to Level: Halloween yet.
So what are your experiences/thoughts on horses & Halloween?


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Releases @ TCC
Three of them made Top-Ten Team
One also named 1 of 50 Coca-Cola Silver Scholars, All-USA
HAMPTON ROADS, VA (April 14, 2011) – Celebrating academic excellence and community involvement, Tidewater Community College recognizes six students or recent graduates selected for three award programs: All-Virginia Academic Team; Top-Ten Team – the highest honor for community college students in Virginia; and a 2011 Coca-Cola Community College Academic Team Silver Scholar – one of 50 winners in the nation.
Alphabetically, the All-Virginia Academic Team winners are: Tianna Blackmon (also Top-Ten); Adam Chakir; Brooke Edwards (also Top-Ten and Coca-Cola Silver Scholar); Maryia Kvashenka (also Top-Ten); Matthew Naneville; and
Christina Parker.
~ Coca-Cola Silver Scholar: Chesapeake resident Brooke Edwards, 19, selected for the Top-Ten Team, also was named – among 50 in the nation – a 2011 Coca-Cola Community College Academic Team Silver Scholar, based on rankings in the All-USA Academic Team competition. She was listed as a winner in the April 11 edition of USA Today. Passionate about animals and the environment, Edwards plans to put her love of the outdoors to work in conservation and environmental science. She came to TCC as a student ambassador from Deep Creek High. While at TCC she shared her time as president of Circle K International, Phi Theta Kappa (PTK, the national community college honor society), vice president of fellowship, Student Government Association (SGA) senator and as a student worker in the provost's office. She also volunteers through her church's food pantry. Edwards graduates in May with a 3.9 grade-point average (GPA) and plans to pursue a bachelor's in environmental science.
~ A Top-Ten Team member and the first in her family to pursue higher education, Tianna Blackmon, 21 and a Chesapeake resident, graduates TCC this May with plans to become a pediatrician. An Indian River High graduate, Blackmon says that TCC helped her 'come out of her shell' and prepared her to be a leader. Blackmon served as the Chesapeake Campus president of PTK, SGA senator and as a member of Circle K International. She also shared her time with Paint Your Heart Out Chesapeake and Our House Families, an agency working to prevent homelessness. Blackmon maintained a 3.9 GPA – a great start toward a medical degree.
~ A Top-Ten Team member who now attends The College of William & Mary, Maryia Kvashenka, 24 and a Virginia Beach resident, came to America from Minsk, Belarus to improve her English skills and decided to stay to pursue a degree. Prior to coming to the states, she completed three years at Minsk State Linguistic University, studying English, German and Spanish. Kvashenka recalls having "culture shock" at first, but was surprised by the resources and the college staff's interest in her career goals. At TCC she became deeply involved with the International Student Alliance and served as PTK treasurer and, later, president. She also volunteered as a dental assistant with the American Red Cross, all while maintaining a 3.9 GPA. Coming from a family of medical practitioners, she plans to pursue a degree in dentistry.
~ Virginia Beach resident Adam Chakir, 43, left his family and all that was familiar to come to America for better job opportunities. A native of Morocco, he holds a bachelor's degree in math from the University of Hassan Second. At TCC, Chakir earned an information systems technology (IST) degree, as well as a database specialist certificate. A PTK member, Chakir maintained a 3.8 GPA. An assistant engineer with an industrial company that manufactures insulators for electric utilities, he plans to change paths and earn a bachelor's in IST and obtain a job in that field.
~ A recent Windsor High graduate, Matthew Naneville, 20 and a Windsor resident, came to TCC because it was an affordable, quality option for continuing his education. This May he graduates with an associate degree in science and plans to earn a second associate degree from TCC – this one in respiratory therapy. From there, he'll pursue a bachelor's in health science from Old Dominion University (ODU). Naneville plans to become a respiratory therapist in a children's hospital and credits his time at TCC as the place where he "cemented his career goals." While at TCC, he shared his talents in the Learning Assistance Center, tutoring students in math and science. A PTK member, Naneville graduates in May with a 3.8 GPA.
~ A graduate of Nansemond River High in Suffolk, Christina Parker, 20, considered other colleges, but chose TCC, noting it's "a good fit" for her, that her professors and counselors go the extra mile to ensure her success. At TCC Parker shares her time as secretary of both the Rotaract Club and the Baptist College Ministry Club, a member of the Science Fiction and Fantasy Club and a tutor in the Learning Assistance Center. She also volunteers as a women's advocate through the YWCA, providing support to families dealing with domestic violence. Parker has a 3.9 GPA and aims to graduate in December with an associate degree in science. She plans to continue at ODU with a dual major in psychology and biology, working toward her goal to become a psychiatrist.
Each Top-Ten Team winner will receive a $500 award; the national Coca-Cola Community College Academic Team Silver Scholar will receive a $1,250 award and a silver medallion. Phi Theta Kappa Honor Society administers the Coca-Cola Community College Academic Team Program and recognizes Coca-Cola scholars during recognition ceremonies held in 37 states. The All-Virginia winners will be honored at a luncheon in Richmond on April 20.
Tidewater Community College - the largest provider of higher education and Workforce Solutions services in Hampton Roads - topped 45,000 students in 2009-10. The 16th highest associate-degree producer in the nation, TCC offers more than 150 programs including business administration, culinary arts, general studies, modeling & simulation, network security, nursing, and automotive technology. Among the fastest-growing two-year institutions in the United States, TCC was founded in 1968 as a part of the Virginia Community College System. The college serves the South Hampton Roads region with campuses in Chesapeake, Norfolk, Portsmouth and Virginia Beach as well as the TCC Jeanne and George Roper Performing Arts Center in Norfolk's theater district, the Visual Arts Center in Olde Towne Portsmouth, the Regional Automotive Center in Chesapeake, and the Advanced Technology Center in Virginia Beach. Forty-five percent of the region's residents attending a college or university in Virginia last fall were enrolled at TCC. For more information, visit www.tcc.edu.


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Welcome to Ultimate Options, and by finding this site you are already a step ahead of everyone else trying to trade options. I have been trading options for about 5 years now and through all of my trials and tribulations I think I have what it takes to provide you with the proper tools, skills, education and daily option and stock picks to help you gain a edge over the other traders. Options are all about timing and a lot of things have to go your way in order to manage a winning trade. If you will take the time to look at all of the different pages and then do the homework of understanding why the market is trading the way it is you can easily separate yourself from the other traders. Currently I am not charging a membership as I am still working on this website. This is not a full time job for me, this is just a passion of mine. I am looking for a few like minded traders to help me create a community of traders that can dominate the options market on a daily basis. PLEASE give me any feedback or things you would like to see on this website.
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