text:
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Widener vs. Fdu-florham
April 12, 2006
|Cullen Burke
|(2, 2)
|Todd Fairlie
|(1, 3)
|Dennis Mann
|(3, 1)
|Luke Weber
|(2, 1)
|Brian Stromko
|(3, 0)
|Gavin Goane
|(1, 1)
|Alan Krawitz
|(2, 0)
|Chris Matthews
|(0, 1)
|Dan Macleish
|(1, 0)
|Marc Liciardello
|(1, 0)
|Darnell Jones
|(1, 0)
|Mike Cozza
|5 (0.833)
|Andrew Johnson
|3 (1.000)
|Tim Collins
|1 (1.000)
|Brian Aguero
|0 (0.000)
|Current Record
|go to Widener page
|Scott Shadiack
|(2, 0)
|Peter Flemming
|(0, 1)
|Bob Moseman
|12 (0.414)
|Current Record
|go to Fdu-florham page
|The Game Story:
|4/12/06 -- Sophomore Brian Stromko (Maplewood, NJ) notched a hat trick in the first half and senior Dennis Mann (Havertown, PA) also scored three goals for Widener, winners of four straight with a 17-2 Middle Atlantic Conference triumph over FDU-Florham at Leslie C. Quick Jr. Stadium.
Widener (7-4, 6-1 MAC), which held FDU scoreless in the opening half, scored four times in the opening quarter. Senior Todd Fairlie (Broomall, PA), the reigning conference Player of the Week who leads the team with 51 points, tallied 13 seconds in the game.
Stromko scored three times in the second quarter for the Pioneers, who opened a 13-0 cushion late in the third quarter. This helped Widener own a 52-19 shots edge, including 32-4 in the first half, and a 34-21 ground balls advantage. The Pioneers also were 4-for-7 with the man advantage.
Freshman Cullen Burke (Drexel Hill, PA), sophomore Luke Weber (Lititz, PA) and senior Alan Krawitz (Havertown, PA) all scored twice and Fairlie dished three assists. Weber was 12-of-14 on face-offs, helping the Pioneers go 16-of-22, and had six ground balls along with junior Darnell Jones (Severn, MD).
Andrew Johnson (Wallingford, PA) made three saves for the victory and fellow junior Mike Cozza (Ridgewood, NJ) added five.
Scott Shadiack scored twice and Peter Fleming dished an assist for the Devils (4-5, 4-3). Bob Moseman made 12 saves.
Widener steps out of conference next Wednesday to host No. 8 Stevens, beginning at 4:00 pm.

subset: commoncrawl


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NDMP incremental backup of N-series and Netapp?
Discussion in 'NDMP' started by tazinblack, Oct 13, 2008.
: incremental, ndmp, needed, tivoli, wanted


text:
Many cruise lines -- including Carnival, Royal Caribbean and NCL -- have multiple ships sailing to the Caribbean out of Florida and the gulf states throughout hurricane season (though the vessels will shy away from the biggest storms, causing itinerary changes). Antarctica cruises pretty much have to traverse the choppy Drake Passage, and Alaska cruises must emerge from the sheltered Inside Passage into the rougher waters of the Gulf of Alaska or the Pacific to reach their homeports.
If you're prone to seasickness or just want to be prepared for high seas and rolling waves, we've compiled a list of some of the bodies of water known for their chop. But first, some tips on sailing through rough water. For a complete report, check out our guide to avoiding seasickness.
Pack your meds. Seasickness remedies do work, and you have a variety from which to choose: Dramamine, Meclizine (common name Bonine) or Transderm Scop, a scopolamine patch applied behind the ear. For drug-free options, some cruisers swear by pressure bands and ginger pills.
Eat right. In addition to all forms of ginger (candy, soda, tea), green apples and bland food like crackers can help you weather any sailing-induced nausea.
Find the horizon. Then stare at it. If you're prone to mal de mer, splurge to upgrade your cabin to one with at least a window. (A balcony is best, as it gives you quick access to fresh air.) Staring at the unmoving horizon will help your body to equilibrate.
Minimize sailing time. If you want to take a cruise but are worried about high seas, look for port-intensive itineraries without many, or any, full days at sea. Then you'll only have to worry about white caps in the evening, rather than all day long.
Opt for smoother sailing. Using our guide, you can look to avoid the roughest seas and pick cruise itineraries with a higher chance of glassy water. River cruises are always calm, or try the Caribbean outside of hurricane season. (Check out our Hurricane Zone for the latest on what's brewing in the tropics.) The Mediterranean's also favorable in the early summer.
Whether you want to embrace rough seas (you hardy sailor, you!) or avoid them, here's where you can find them.
Ocean Crossings
Rough Waters: Oceans are nearly always choppier than seas because they're less protected from sheltering land masses. If you've booked a transatlantic cruise (especially in the cooler months) or a transpacific cruise (including those to Hawaii), you may encounter some bumps. The North Atlantic by northern Canada has its fair share of high seas, as well.
Impacted Itineraries: transatlantic, transpacific, Hawaii, Canada and New England, world cruises
Rough Waters: Cruise travelers may experience rough seas in several places in Europe. The biggest offender is the Mediterranean, which tends to be roughest in the fall and winter, due to winds and storms. However, avid cruisers have experienced rough seas in the spring and summer, so be prepared for anything. The Bay of Biscay, off the west coast of France and north of Spain, and the North Sea can also be rough but are calmest in the summertime.
Impacted Itineraries: Eastern and Western Mediterranean, Western Europe, Baltic and Northern Europe
Rough Waters: When one body of water runs into another, waves tend to be higher and rougher. Although the Caribbean is known for smooth sailing, it gets choppier at the point where it meets up with the Atlantic Ocean. In addition, tropical depressions, storms and hurricanes that crop up during hurricane season (June 1 - November 30) can also stir up the usually calm Caribbean waters and make for a rocky trip -- even if your ship is changing course to avoid the brunt of the storm.
Impacted Itineraries: Eastern, Southern and Western Caribbean
North America
Rough Waters: The majority of sailing on an Alaska cruise is done in the protected waters of the Inside Passage, but ships sailing to Seward, Whittier or Anchorage must cross the Gulf of Alaska, which is much rougher. Cruise staffers say the gulf gets especially bad after Labor Day, in the shoulder season.
Impacted Itineraries: one-way Alaska sailings
South America
Rough Waters: One of the most notorious places for rock-and-roll cruising is Drake Passage, the body of water between Cape Horn, the southernmost tip of South America, and the South Shetland Islands in Antarctica. Although you can get lucky and find smooth seas, most cruise travelers experience rough waters traversing this region.
Impacted Itineraries: Antarctica
Rough Waters: The typhoon season in the northwest Pacific Ocean is mainly from July to November with a peak in late August/early September -- although storms can occur year-round. Encounter a storm in the South China Sea or other Asian waters, and you may find an unpleasant ride, not to mention some skipped ports.
Impacted Itineraries: China, Japan, the Philippines and Korea
Rough Waters: If you're cruising Down Under, you'll find some rough patches in the Bass Strait (between the Australian mainland and Tasmania) and the Tasman Sea (between Australia and New Zealand).
Impacted Itineraries: Australia and New Zealand cruises, world cruises
Rough Waters: Not many cruise lines sail to Africa, but if your itinerary includes South African destinations, watch out! The waters around the Cape of Good Hope, especially where the Atlantic meets the Indian Ocean, can be pretty choppy.
Impacted Itineraries: world cruises, Africa cruises
Cruise Critic's Most Popular Stories:
9 Things To Do on a Cruise Ship Balcony and 1 Not To
Slideshow: Battle of the Onboard Evildoers
Refurb Chart: Cruise Ship Makeovers
The Ultimate Guide to Cruise Ship Tipping
--by Erica Silverstein, Features Editor


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Submit News
Fisker Appoints New CEO, Eliminates Battery/Engine Compartment as Causes for Fire
Tiffany Kaiser
August 14, 2012 10:49 PM
comment(s) - last by
Aug 17
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Fisker's new CEO Tony Posawatz
(Source: media.gm.com)
Tony Posawatz is replacing Tom LaSorda after only six months as Fisker CEO
After only six months of service and a laundry list of troubles, Fisker Automotive's CEO has been booted from his position.
Tom LaSorda, who was named CEO of Fisker back in February 2012 when founder Henrik Fisker stepped down, is leaving the company, but will still be an adviser. He is being replaced by Tony Posawatz, who was the former head of
Chevrolet Volt
production for General Motors.
Posawatz has 30 years of experience at General Motors, and was a large part of bringing the Volt from concept to production.
"We are delighted to be adding an executive of Tony's caliber to the Fisker Automotive leadership team," said Fisker. "His depth of knowledge and experience in this innovative field of new technology means that he is one of the world's most experienced leaders in vehicle electrification technology and the plug-in ecosystem. In the long-term, he will ensure that Fisker is well positioned to maximize the potential of not only
the Karma sedan
, but also bring the Fisker Atlantic smoothly to market."
Just last week,
Fisker had its second incident where a Karma plug-in caught fire
while in the possession of a customer. The first occurred only four months sooner in a customer's garage in Houston, causing a house fire.
Last week's incident happened in a Woodside, California grocery store parking lot while the customer was inside shopping. When he came outside, his Karma was on fire and had to be put out by the Woodside Fire Department. There was considerable damage to the vehicle.
There are many speculations as to how the fire started, such as issues with
the lithium ion battery
(which the company had to recall in December 2011) and the "crowded" engine compartment/exhaust routing method.
Fisker recently confirmed that none of these rumors are true. The automaker has started investigating the cause of the Woodside fire, and while there is no set conclusion yet, it has ruled out those possible sources.
"The area of origin for the fire was determined to be outside the engine compartment," said Fisker in a statement. "There was no damage to the passenger compartment and there were no injuries.
"Continued investigative efforts will be primarily focused within the specific area of origin, located forward on the driver's side front tire. Further details will be announced after a full report is completed."
In addition to Karma-related issues, Fisker has had troubles with its Atlantic hybrid, which
may have to be built outside of the United States
because of its lack of access to government funds.
In April 2010, California-based Fisker Automotive received a total of $529 million from the U.S. Department of Energy (DOE) for clean vehicles, but in May 2011, DOE froze its loans after
delivery of the Karma plug-in was delayed and ended up falling behind schedule. DOE said Fisker did not meet the milestones previously promised, and since then, Fisker has not been able to access the DOE loans.
The loans were also meant to revamp a closed General Motors plant in Wilmington, Delaware for Fisker auto production. So far, Fisker has drawn down $193 million from its loans, but there's a chance that the company may never see the rest of it.
In February 2012, Fisker was forced to
lay off 26 factory workers at the Delaware plant
In addition to the CEO shake-up, Fisker appointed Joe Chao to executive vice president and CEO of Fisker China and Asia. Also, Alberto Gonzalez was named vice president of Manufacturing.
Fisker Automotive
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RE: Fresh, New, Different
Just to bring you up to date, Reclaimer77, the U.S. is now importing MORE oil from Saudi Arabia and the middle east:
The United States is increasing its dependence on oil from Saudi Arabia, raising its imports from the kingdom by more than 20 percent this year, even as fears of military conflict in the tinderbox Persian Gulf region grow.
"At a time when there is a rising chance of either a nuclear Iran or an Israeli strike on Iran's nuclear facilities, we should be trying to reduce our reliance on oil going through the Strait of Hormuz and not increasing it," said Michael Makovsky, a former Defense Department official who worked on Middle East issues in the George W. Bush administration.
I'm surprised at the number of people like "Reclaimer77" and "freedom4556" who CHOOSE to use imported oil for their transportation when they could instead use U.S.-made electricity.
They CHOOSE to support the Saudis and Hugo Chavez instead of buying American electricity for their cars. Why???
"A politician stumbles over himself... Then they pick it out. They edit it. He runs the clip, and then he makes a funny face, and the whole audience has a Pavlovian response." -- Joe Scarborough on John Stewart over Jim Cramer
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Many chemotherapeutic agents have been used to treat pancreatic cancer without success. Apigenin, a naturally occurring flavonoid, has been shown to inhibit growth in some cancer cell lines but has not been studied in pancreatic cancer. We hypothesized that apigenin would inhibit pancreatic cancer cell growth in vitro.
Apigenin caused both time- and concentration-dependent inhibition of DNA synthesis and cell proliferation in four pancreatic cancer cell lines. Apigenin induced G2/M phase cell cycle arrest. Apigenin reduced levels of cyclin A, cyclin B, phosphorylated forms of cdc2 and cdc25, which are all proteins required for G2/M transition.
Apigenin inhibits growth of pancreatic cancer cells through suppression of cyclin B-associated cdc2 activity and G2/M arrest, and may be a valuable drug for the treatment or prevention of pancreatic cancer.
Despite attempts of resection and adjuvant therapy, patients diagnosed with pancreatic cancer continue to have a poor prognosis. Many chemotherapeutic agents have been used to treat pancreatic cancer without particular success. Novel treatments to inhibit cancer cell proliferation with less toxicity are needed. Flavonoids are a class of polyphenolic compounds which display a variety of biologic activities. There has been recent interest in using flavonoid derivatives therapeutically as anticancer drugs. At pharmacological levels, various naturally occurring flavonoids have been shown to be cancer-protective in a variety of animal models. Flavonoid derivatives, such as flavopiridol and genistein, have been shown to be safe in human trials[1,2] and are being assessed as chemotherapy drugs in phase II clinical trials for advanced solid tumors [3,4].
Flavonoids have shown antitumor activity for a number of cancer cell types [5,6]. This is mediated by different types of cell cycle arrest and the induction of apoptosis in several tumor cell lines [7-12]. Genistein, a naturally occurring isoflavone, has shown antitumor activity in pancreatic cancer models [13]. Apigenin, an isoconformer of genistein, has shown more potent growth inhibition in several cancer cell lines [6]. Apigenin has been shown to possess anti-inflammatory effects, free radical scavenging properties, and anti-carcinogenic effects [14]. It has been shown to possess growth inhibitory properties in several cancer lines, including breast, colon, skin, thyroid, and leukemia cells [15-19], but has never been studied in pancreatic cancer. We hypothesized that apigenin would inhibit pancreatic cancer cell growth in vitro, and further aimed to delineate the mechanism involved.
Apigenin inhibited DNA synthesis
Apigenin caused a concentration-dependent (6.25–100 μM) inhibition of thymidine incorporation in all four cell lines studied (Figure 1). At 24 hours, 100 μM apigenin caused an approximately 50% inhibition of thymidine incorporation in each cell line. The inhibition of proliferation was statistically significant (P < 0.01) at 100 μM apigenin in all cell lines.
Figure 1. Effects of apigenin on DNA synthesis in human pancreatic cancer cells. Apigenin caused significant concentration-dependent inhibition of DNA synthesis in all four cell lines studied: AsPC-1 [F (5,42) = 10.12, P < 0.0001; P = 0.01 with 50–100 μM]; CD18 [F (5,54) = 38.47, P < 0.0001; P < 0.01 with 12.5–100 μM]; MIA PaCa2 [F (5,72) = 8.698, P < 0.0001; P < 0.05 with 25 μM and P < 0.01 with 50–100 μM]; S2-013 [F (5,72) = 4.099, P < 0.0025; P < 0.05 with 50 μM and P < 0.01 with 100 μM]. Data represent results from at least three separate experiments each performed in triplicate, expressed as a percentage of control.
Apigenin inhibited cell proliferation
The inhibition of DNA synthesis correlated with a decrease in cell number over a 72-hour period when compared with control. The cell number in untreated cells increased every 24 hours in almost every cell line while cell number of apigenin-treated cells increased at a slower rate, or decreased (Figure 2). The differences in cell number were statistically significant (P < 0.05) at 72 hours in all four cell lines. During the first 24 hours, no significant difference was seen between cells treated with apigenin and controls. Only viable cells were counted so that cytotoxicity did not play a role.
Figure 2. Time-course effects of apigenin on cell number of human pancreatic cells. Apigenin significantly inhibited the increase in cell number of each cell line over time: AsPC-1, [F (5,59) = 10.65, P < 0.0001], P < 0.05 at 48 h and P < 0.001 at 72 h; CD18, [F (5,38) = 5.641, P < 0.0006], P < 0.001 at 72 h; MIA PaCa2, [F (5,65) = 6.127, P < 0.0001], P < 0.001 at 72 h; S2-013, [F (5,60) = 2.589, P < 0.0347], P < 0.05 at 72 h. Data represent results from at least three separate experiments each performed in triplicate, expressed as cell number/well. *= P < 0.05; **= P < 0.01; ***= P < 0.001 compared with control.
Apigenin induced G2/M phase cell cycle arrest
In order to better understand the mechanism of inhibition of cell proliferation, the distribution of cells in the different phases of the cell cycle was analyzed following treatment with 100 μM apigenin for 24 hours. There were marked and consistent changes in the cell cycle at 24 hours. The number of cells in the G2/M phase increased in all four cell lines with a concomitant decrease in treated cells in the G0/G1 and S phase. The difference between the mean percentage of control and treated cells in the G2/M phase of four separate experiments was statistically significant in all four cell lines (AsPC1: P < 0.01, CD18: P < 0.009, MiaPaCa2: P < 0.04; S2013: P < 0.03). Figure 3 shows the results of one experiment representative of all cell cycle experiments. The concentration-dependent effects of apigenin on the proportion of cells in the G2/M phase of the cell cycle are shown in Figure 4.
Figure 3. Effects of apigenin on the proportion of cells in different phases of the cell cycle. Apigenin caused G2/M arrest in all four human pancreatic cancer cell lines studied. Similar results were seen in four different experiments.
Figure 4. Concentration-dependent effects of apigenin on the cell cycle. Higher concentrations of apigenin cause a concomitant increase in the percentage of cells in the G2/M phase. AsPC-1 [F (3,8) = 12.79, P < 0.002 (P < 0.01 with 100 μM)]; CD18 [F (3,8) = 9.504, P < 0.0128 (P < 0.05 with 50 μM and P < 0.01 with 100 μM)]; MIA PaCa2 [F (3,10) = 6.062, P < 0.0128(P < 0.01 with 100 μM)]; S2-013 [F (3,10) = 4.071, P < 0.0394 (P < 0.05 with 100 μM)]. *= P < 0.05; **= P < 0.01 compared with control.
Apigenin changed expression of proteins involved in the G2/M phase transition
All four pancreatic cancer cell lines were treated with 100 μM apigenin for 24 hours and expression and phosphorylation of proteins involved in the G2/M transition were observed through western blotting (Figure 5). Expression of cyclin A and B was decreased in apigenin treated cells when compared to controls. While expression of cdc2 was unchanged, the levels of phosphorylated cdc2 were decreased in apigenin treated cells. Expression of cdc25A and cdc25C were also decreased in apigenin treated cells compared to controls.
Figure 5. Effects of apigenin on proteins involved in the G2/M cell cycle phase transition. Expression of both cyclin A and cyclin B were both decreased in apigenin-treated cells compared to controls. While the expression of the cdc2 protein was unchanged, levels of phosphorylated cdc2 were decreased in treated cells. Expression of cdc25A and cdc25C were also decreased in treated cells compared to controls.
Several mechanisms have been proposed for apigenin's effect on cell growth including modulation of the MAP kinase pathway [20,21], inhibition of ornithine decarboxylase [22], improvement in cell-cell communication through increased gap junctions [23], and cell cycle arrest. Cell-cycle checkpoints at G2/M as well as G1/S are critical in maintaining DNA integrity and regulating the passage of cells through the cell cycle. It is well known that loss of these checkpoints is involved in the transformation into and progression of cancer cells. A protein kinase complex consisting of a catalytic subunit, cdc2, and the cyclin B protein performs the central and rate-limiting function in the transition from G2 to M phase [24]. The cdc2/cyclin B complex responds to DNA damage and causes a delay in cell cycle progression to allow DNA repair before cells enter mitosis. The complex accomplishes this through phosphorylation of cytoskeleton proteins such as lamins and histone H1 [25]. Cdc2 binding to cyclin B in and of itself is not enough, however, for checkpoint progression. Dephosphorylation of cdc2 at the Tyr-15 site through cdc25c phosphatase is required for activation of the complex [24,26]. Cdc25A also contributes to the cellular phosphatase pool required to dephosphorylate cdc2 fully [27]. Cyclin A, known mainly for its role in G1/S transition, is also required for the entry of cells into mitosis [28,29].
In the current study, treatment of human pancreatic cancer cells with apigenin resulted in inhibition of DNA synthesis and cell proliferation through G2/M cell cycle arrest. A decrease in levels of cyclin A, cyclin B, cdc25 A and cdc25C all appear to be involved. It is not clear why levels of phosphorylated cdc2 were decreased given that reduced levels of cdc25c should have the opposite effect, however, the reduced levels of cyclin B appear to be the main mechanism involved in the arrest of cells at G2/M.
Our results are congruent with previous studies in which cell cycle arrest has been shown to result from apigenin treatment in other cell lines. G2/M arrest through inhibition of cyclin B associated cdc2 has been shown to occur in epidermal and fibroblast cells [8,30], breast cancer cells [31], oral cancer cells [32], melanoma [33], mouse keratinocytes [34], endothelial cells [35], prostate cancer cells [36], and colon cancer cell lines [16]. Interestingly, inhibition of cyclin B appears to be concentration-related as lower doses have less effect while higher doses (>70 μM) as we used in our study decrease cyclin B levels [34].
A considerable amount of attention has been given to the role of p53 in cell cycle checkpoint control. P53 blocks cells at G2/M through direct inhibition of cdc2 kinase [37]. All four cell lines used in this study contain mutated p53, which implies that the G2/M arrest seen after apigenin treatment is through a p53-independent pathway. Other studies have found this to be the case as well. Apigenin was found to inhibit growth in both p53 wild-type and mutated breast cancer cells [15], p53 mutated oral squamous cell cancer cells [32], and mutated colon cancer cell lines [16].
To our knowledge there is no published data concerning apigenin in pancreatic cancer. Our results demonstrate that apigenin inhibits human pancreatic cancer cell growth in vitro through G2/M phase cell cycle arrest associated with decreased cyclin B-cdc2 activity. Taken together with previously published studies, apigenin appears to exert its inhibitory effects on cell cycle progression in other cell lines as well. Cancer cells with abnormal cell-cycle machinery may benefit from extrinsic cell-cycle regulators such as apigenin.
DMEM, trypsin-EDTA solution, and propidium iodide were purchased from Sigma (St. Louis, MO). Fetal bovine serum was purchased from Atlanta Biologicals (Norcross, GA). Apigenin was purchased from Calbiochem (Darmstadt, Germany) and dissolved in DMSO purchased from Sigma Chemicals (St. Louis, MO). Methyl 3H-Thymidine was purchased from Amersham (Arlington Heights, IL). The monoclonal mouse cyclin A, B, cdc25A, and GAPDH antibodies, and the polyclonal rabbit cdc25C antibody were purchased from Santa Cruz Biotechnology (Santa Cruz, CA). The monoclonal rabbit cdc2 and phospho-cdc2 (Tyr15) antibodies were purchased from Cell Signaling Technology, Inc. (Beverly, MA).
Human pancreatic cancer cell lines and cell culture
We selected four human pancreatic cancer cell lines: AsPC-1, CD18, MIA PaCa2, and S2-013. These cell lines were purchased from American Type Culture Collection (Manassas, VA) with the exception of the S2-013 cell line, which was a generous gift from Dr. Takeshi Iwamura (Japan). Each cell line was grown in DMEM and plated as monolayers in medium supplemented with 10% fetal bovine serum in a humidified atmosphere of 95% O2 and 5% CO2 at 37°C. The cells were regularly seeded into 75-cm2 flasks with media changes every second or third day. For experiments, cells were grown to 70% confluence, digested with trypsin-EDTA, and plated in 6-, 24-, or 48-well plates.
DNA synthesis by methyl-3H thymidine incorporation
Cells were plated in 24-well plates at a concentration of 50,000 cells/well. After reaching 50% confluence, they were incubated in serum-free medium for 24 hours, which was then replaced with fresh serum-free medium with or without the appropriate treatments. After the required period of culture, cellular DNA synthesis was assayed by adding 0.5μCi methyl 3H-thymidine/well and incubating cells for another 6 hours. The cells were then washed twice with PBS, fixed with 10% trichloroacetic acid, and solubilized by adding 250 μl of 0.4 M NaOH to each well. Radioactivity, indicating incorporation of methyl 3H-thymidine into DNA, was measured by adding scintillation cocktail and counting on a scintillation counter (LKB RackBeta; Wallac, Turku, Finland).
Cell proliferation assay
Cells were regularly seeded into three 6-well plates and incubated at 37°C for 24 hours. Cells were then cultured in serum-free medium for another 24 hours and treated in fresh serum-free medium with or without apigenin for 24, 48, and 72 hours. At the end of each time period, the cells were trypsinized to produce a single cell suspension, and the viable cell number in each well was counted using Guava Technologies' ViaCount Assay (Guava Technologies Inc, Hayward, CA).
Analysis of cellular DNA content by flow cytometry
Cells were grown to 50% confluence in T75-cm2 flasks, serum starved for 24 hours, and then treated with apigenin. At the end of the treatment, the cells were harvested with trypsin-EDTA solution to produce a single-cell suspension. Cells were then pelleted by centrifugation and washed twice with PBS. The cell pellets were then suspended in 0.5 mL PBS and fixed in ice-cold 70% ethanol at 4°C. The fixed cells were then centrifuged at ×300 g for 10 minutes and pellets washed with PBS. After resuspension in 1 ml PBS, the cells were incubated with 10 μL Rnase I (10 mg/ml) and 100 μL propidium iodide (400 g/mL) and shaken for 1 hour at 37°C in the dark. The samples were then analyzed by flow cytometry.
Western blotting
Cells were seeded in T25-cm2 flasks and grown to 60% confluence for 24 hours. The cells were serum starved for 24 hours. The cells were then placed in serum-free medium with or without 100 μM apigenin for 24 hours. The cells were lysed and protein concentrations determined with BSA as standard. Equal amounts of cell protein lysate were separated on 15% SDS-polyacrylamide gel electrophoresis (PAGE) and the protein transferred onto nitrocellulose membranes. After blocking with dried milk, membranes were incubated with the appropriate dilution of primary antibody. Membranes were then incubated with a horseradish peroxidase-conjugated secondary antibody. Proteins were detected using the enhanced chemiluminescence detection system.
Statistical analysis
Data were analyzed by ANOVA with Dunnett's or Bonferoni's corrections for multiple comparisons, as appropriate. This analysis was performed with the Prism software package (GraphPad, San Diego, CA). Data were expressed as mean ± SEM.
Authors' contributions
MU carried out the cell culture work, thymidine incorporation, cell proliferation assays, flow cytometry, statistical analyses, and wrote the manuscript. XD participated in the conception of the study, its design and coordination, and helped draft the manuscript. MS carried out the western blotting. LG assisted with cell proliferation assays and western blotting. BM assisted with cell proliferation assays and western blotting. DB helped draft and prepare the manuscript. MT and RB participated in the design and coordination of the study. TA participated in the conception and design of the study, participated in the statistical analysis, participated in the coordination of the study and edited the manuscript.
Shah MA, Kortmansky J, Motwani I, Drobnjak M, Gonen M, Yi S, Weyerbacher A, Cordon-Cardo C, Lefkowitz R, Brenner B, O'Reilly E, Saltz L, Tong W, Kelsen DP, Schwartz GK: A phase I clinical trial of sequential combination of irinotecan followed by flavopiridol.
Clin Cancer Res 2005, 11:3836-3845. PubMed Abstract | Publisher Full Text
Whitlock JA, Krailo M, Reid JM, Ruben SL, Ames MM, Owen W, Reaman G: Phase I clinical and pharmacokinetic study of flavopiridol in children with refractory solid tumors: a Children's Oncology Group Study.
J Clin Oncol 2005, 23:9179-9186. PubMed Abstract | Publisher Full Text
deVere White RW, Hackman RM, Soares SE, Beckett LA, Li Y, Sun B: Effects of a genistein-rich extract on PSA levels in men with a history of prostate cancer.
Urology 2004, 63:259-263. PubMed Abstract | Publisher Full Text
Kelland LR: Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: current status.
Expert Opin Investig Drugs 2000, 9:2903-2911. PubMed Abstract | Publisher Full Text
Fotsis T, Pepper MS, Aktas E, Breit S, Rasku S, Adlercreutz H, Wahala K, Montesano R, Schweigerer L: Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis.
Cancer Res 1997, 57:2916-2921. PubMed Abstract | Publisher Full Text
Li Y, Ahmed F, Ali S, Philip PA, Kucuk O, Sarkar FH: Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells.
Cancer Res 2005, 65:6934-6942. PubMed Abstract | Publisher Full Text
Gupta S, Afaq F, Mukhtar H: Involvement of nuclear factor-kappa B, bax and bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells.
Oncogene 2002, 21:3727-3738. PubMed Abstract | Publisher Full Text
Lepley DM, Li B, Birt DF, Pelling JC: The chemopreventive flavonoid apigenin induces G2/M arrest in keratinocytes.
Carcinogenesis 1996, 17:2367-2375. PubMed Abstract
Losiewicz MD, Carlson BA, Kaur G, Sausville EA, Worland PJ: Potent inhibition of cdc2 kinase activity by the flavonoid L86-8275.
Biochem Biophys Res Commun 1994, 201:589-595. PubMed Abstract | Publisher Full Text
Kobayashi T, Nakata T, Kuzumaki T: Effect of flavonoids on cell cycle progression in prostate cancer cells.
Cancer Lett 2002, 176:17-23. PubMed Abstract | Publisher Full Text
Wang H: The therapeutic potential of flavonoids.
Expert Opin Investig Drugs 2000, 9:2103-2119. PubMed Abstract | Publisher Full Text
Birt D, Hendrich S, Wang W: Dietary agents in cancer prevention: flavonoids and isoflavonoids.
Pharmacol Ther 2001, 90:157-177. PubMed Abstract | Publisher Full Text
Buchler P, Reber HA, Buchler MW, Friess H, Lavey RS, Hines OJ: Antiangiogenic activity of genistein in pancreatic carcinoma cells is mediated by the inhibition of hypoxia-inducible factor-1 and the down-regulation of VEGF gene expression.
Cancer 2004, 100:201-210. PubMed Abstract | Publisher Full Text
Kim HP, Mani I, Iversen L, Ziboh VA: Effects of naturally-occurring flavonoids and bioflavonoids on epidermal cyclooxygenase and lipoxygenase from guinea-pigs.
Prostaglandins Leukot Essent Fatty Acids 1998, 58:17-24. PubMed Abstract | Publisher Full Text
Yin F, Giuliano AE, Law RE, Van Herle AJ: Apigenin inhibits growth and induces G2/M arrest by modulating cyclin-cdk regulators and ERK MAP kinase activation in breast carcinoma cells.
Anticancer Res 2001, 21:413-420. PubMed Abstract
Wang W, Heideman L, Chung CS, Pelling JC, Koehler KJ, Birt DF: Cell-cycle arrest at G2/M and growth inhibition by apigenin in human colon carcinoma cell lines.
Mol Carcinog 2000, 28:102-110. PubMed Abstract | Publisher Full Text
Caltagirone S, Rossi C, Poggi A, Ranelletti FO, Natali PG, Brunetti M, Aiello FB, Piantelli M: Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential.
Int J Cancer 2000, 87:595-600. PubMed Abstract | Publisher Full Text
Yin F, Giuliano AE, Van Herle AJ: Growth inhibitory effects of flavonoids in human thyroid cancer cell lines.
Thyroid 1999, 9:369-376. PubMed Abstract
Takahashi T, Kobori M, Shinmoto H, Tsushida T: Structure-activity relationships of flavonoids and the induction of granulocytic- or monocytic-differentiation in HL60 human myeloid leukemia cells.
Biosci Biotechnol Biochem 1998, 62:2199-2204. PubMed Abstract | Publisher Full Text
Kuo ML, Yang NC: Reversion of v-H-ras-transformed NIH 3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes.
Biochem Biophys Res Commun 1995, 212:767-775. PubMed Abstract | Publisher Full Text
Van Dross R, Xue Y, Knudson A, Pelling JC: The chemopreventive bioflavonoid apigenin modulates signal transduction pathways in keratinocyte and colon carcinoma cell lines.
Wei H, Tye L, Bresnick E, Birt DF: Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice.
Cancer Res 1990, 50:499-502. PubMed Abstract | Publisher Full Text
Chaumontet C, Droumaguet C, Bex V, Heberden C, Gaillard-Sanchez I, Martel P: Flavonoids (apigenin, tangeretin) counteract tumor promoter-induced inhibition of intercellular communication of rat liver epithelial cells.
Cancer Lett 1997, 114:207-210. PubMed Abstract | Publisher Full Text
Norbury C, Nurse P: Animal cell cycles and their control.
Annu Rev Biochem 1992, 61:441-470. PubMed Abstract | Publisher Full Text
Johnson DG, Walker CL: Cyclins and cell cycle checkpoints.
Annu Rev Parmacol Toxicol 1999, 39:295-312. Publisher Full Text
Sampath D, Plunkett W: Design of new anticancer therapies targeting cell cycle checkpoint pathways.
Curr Opin Oncol 2001, 13:484-490. PubMed Abstract | Publisher Full Text
Mailand N, Podtelejnikov AV, Groth A, Mann M, Bartek J, Lukas J: Regulation of G2/M events by cdc25A through phosphorylation-dependent modulation of its stability.
EMBO J 2002, 21:5911-5920. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Furuno N, Den Elzen N, Pines J: Human cyclin A is required for mitosis until mid prophase.
J Cell Biol 1999, 147:95-306. Publisher Full Text
Pagano M, Pepperkok R, Verde F, Angorge W, Draetta G: Cyclin A is required at two points in the human cell cycle.
EMBO J 1992, 11:961-971. PubMed Abstract | PubMed Central Full Text
Lepley DM, Pelling JC: Induction of p21/WAF1 and G1 cell-cycle arrest by the chemopreventive agent apigenin.
Mol Carcinog 1997, 19:74-82. PubMed Abstract | Publisher Full Text
Lindenmeyer F, Li H, Menashi S, Soria C, Lu H: Apigenin acts on the tumor cell invasion process and regulates protease production.
Nutr Cancer 2001, 39:139-147. PubMed Abstract | Publisher Full Text
O'Prey J, Brown J, Fleming J, Harrison PR: Effects of dietary flavonoids on major signal transduction pathways in human epithelial cells.
Biochem Pharmacol 2003, 66:2075-2088. PubMed Abstract | Publisher Full Text
Casagrande F, Darbon JM: Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1.
Biochem Pharmacol 2001, 61:1205-1215. PubMed Abstract | Publisher Full Text
McVean M, Weinberg WC, Pelling JC: A p21WAF1-independent pathway for inhibitory phosphorylation of cyclin-dependent kinase p34cdc2 and concomitant G2/M arrest by the chemopreventive flavonoid apigenin.
Mol Carcinog 2002, 33:36-43. PubMed Abstract | Publisher Full Text
Trochon V, Blot E, Cymbalista F, Engelman C, Tang R, Thomaidis A, Vasse M, Soria J, Lu H, Soria C: Apigenin inhibits endothelial-cell proliferation in G2/M phase whereas it stimulates smooth-muscle cells by inhibiting p21 and p27 expression.
Int J Cancer 2000, 85:691-696. PubMed Abstract | Publisher Full Text
Gupta S, Afaq F, Mukhtar H: Selective growth-inhibitory, cell-cycle deregulatory and apoptotic response of apigenin in normal versus human prostate carcinoma cells.
Biochem Res Commun 2001, 287:914-920. Publisher Full Text
Taylor WR, Stark GR: Regulation of the G2/M transition by p53.
Oncogene 2001, 20:1803-1815. PubMed Abstract | Publisher Full Text


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Best of News
A devotee secures a cloth over a pole at a Sikh shrine in Lahore on... News PhotoAnniversary,Death,Horizontal,Lahore,Loyalty,Pakistan,Pilgrim,Religion,Shrine,Sikhism,TextilePhotographer ARIF ALICollection: AFP 2013 AFPA devotee secures a cloth over a pole at a Sikh shrine in Lahore on June 29, 2013, on the 174th death anniversary of Maharaja Ranjit Singh. Singh was also known as 'Sher-e-Punjab' or 'Lion of Punjab' and is remembered for uniting the Punjab as a strong nation and his possession of the Koh-i-noor diamond. Singh, who was born in Gujranwala in 1780, was the ruler of the Pakistani Punjab province and died on June 27, 1839. AFP PHOTO/Arif ALI (Photo credit should read Arif Ali/AFP/Getty Images)


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Issue 12.04 | April 2004
this article for free.
The God Particle and the Grid (continued)
The result: a super-reliable, superpowerful network that supplies on-demand computing capacity anytime, anywhere.
The key is middleware called the Globus Toolkit, an open source project led by Kesselman (who now runs the Information Sciences Institute at USC) - and Ian Foster of the Argonne National Lab in Illinois. They're the Lewis and Clark of grid computing - in fact, they wrote the 750-page book on it. Globus enables a grid to interpret a user request and then autonomously find the appropriate computing resources. Then it breaks the job into the right kinds of smaller tasks, allocates the spare computing power, and gets to work solving the problem. Robertson and his team at CERN have also integrated software developed for various grid projects around the world, but the Globus Toolkit still provides core protocols.
On the LHC grid, that software is supposed to solve a colossal signal-to-noise problem. It involves combing through mundane particle interactions for traces of "new physics" and comparing those traces to a simulation of what Higgs is supposed to look like. The CPU cycles could come from Birmingham or Berkeley or Beijing; a physicist working the problem won't know where the capacity comes from, and won't care.
In the 1960s, networking pioneers like J.C.R. Licklider and Leonard Kleinrock envisioned the spread of what Kleinrock called "computer utilities" - pervasive services that would provide remote computing to individuals. In the 1990s, the spread of computer clusters and the business model known as Web services brought that vision closer to reality. But clusters are by definition centralized, independent nodes of computers managed by a single authority. It took high-speed networks and sophisticated software - much of it created by Foster and Kesselman - to make grid computing possible.
"We're still doing things the old-fashioned way: You carry around your own computer, that's your computation tool. The grid will change all that," says Foster. At least, that's the theory. To find out if it works, its architects are pumping more and more simulated data through the grid, waiting for the Atlas detector to come online.
When I toured CERN last fall, Atlas was under construction on the back lot in a building as big as a hangar. The components are so heavy that they rest on supports that float on cushions of pressurized air, as precarious as elephants on skateboards. ("You could push one of these with your hands," physicist Robert McPherson told me as he showed me around. "But you don't want to.")
Later, I stood in the cathedral-sized cavern that will eventually house Atlas, 200 feet beneath the Swiss countryside. Jean-Luc Baldy, CERN's head of engineering, gestured toward metal platforms that stretched hundreds of feet above us. "The easy part was digging the hole," he remarked with Gallic understatement. "Getting the machine into the hole is much harder." As we talked, powerful forklifts moved blue steel beams as welders built a cradle for the detector, which will weigh as much as a small ocean liner. Above Baldy's head, laborers in hard hats clambered over the metal scaffolding, finishing the chamber's interior. It was like a scene from Dr. No; at any moment I expected a nuclear-tipped missile to rise from the floor and the roof to slide open.
As particles arc through Atlas' intricate viscera after a collision, they leave traces, electrical impulses that Atlas translates into streams of 1s and 0s. Transmitted to physicists' desktops around the globe, those numerical streams may contain the evidence for the God particle.
The problem here is volume, not complexity. To model the chaotic effects of, say, earthquakes or the global climate, you need complicated algorithms and intelligent software; by contrast, the work of the LHC grid is essentially data mining in a huge mountain of numbers. As Robertson puts it, the output from the LHC is "perfectly parallel." Each collision is an independent event, separate from the previous one and the next, so it's relatively easy to break the datastream into bundles and analyze each in parallel, across many distributed computers, before recombining them. From their mathematical models, physicists can deduce the particular combination of energy, momentum, and charge that the Higgs boson should have. Teasing it out from all the other, mundane particle tracks is "a big job, requiring vast amounts of computing power," Robertson says. "But you can just break it into as many jobs as you have processors available, run it as long as it takes, and then put the results together."
Will the LHC grid perform as they hope? The networking speed is already there. Last October, Newman's group at Caltech and Robertson's team at CERN set a new Internet land-speed record for data transfer. They sent a terabyte of data across 4,400 miles in less than 30 minutes. That's 5.44 gigabits a second, or about one DVD every seven seconds - five times as fast as the old record, which they themselves had set just eight months earlier.
Network infrastructure also poses no problem. Thanks to the excesses of the 1990s telecommunications bubble, there's plenty of so-called dark fiber in the ground, laid but unused and going for cheap. So grid projects like the LHC can afford to lease their own networks rather than pay for bandwidth.
The real obstacle is cost. Serving just 100 scientists a day - 100 workstations operating on a terabyte of data - would fully occupy a 10-gigabit link, the largest pipeline in production today, according to Newman. While that's cheaper today than it once was, it's still a bill for someone. And that doesn't include the cost of the computational power at the centers that will contribute to the grid.
"The original grid concepts implicitly assumed that there would be plenty of resources," says Newman. Plan it, figure out how it will work, and grid computing should just happen. But "in the real world, it doesn't work like that."
That's the crucial distinction between grids and the Web. Information may want to be free, but doing work with it costs money. "When we make this leap to utility processing, it will theoretically give you access to computing power without knowing the details, just as the Web gives you access to information without knowing where it's stored," says Robertson. "But on the Web, there's so much information available, because people want to make it available without charging for it, and the cost of making it available is quite low. But is there so much high-performance computing capacity available that people want to give it away?"
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MANASSAS, Va. (WUSA9) -- One man has been arrested after he assaulted and choked a woman, police say.
Brian Xavier Swain, 26, was arrested after he grabbed a woman by her hair, dragged her, choked her and further assaulted her, police said.
It happened around 11:30 p.m. on Tuesday, police said.
Swain knew the woman, who suffered minor injuries, police said.
Read or Share this story: http://on.wusa9.com/1gCcOUW


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Head coach Carl Africo points to one game in particular to define Central Falls High senior forward Cristian Rodriguez' uncanny ability to put the ball in the net.
"We were playing Smithfield in a non-league match, and – early on – the guys really didn't know how to play him," Africo recalled late last week of what turned out to be a 6-1 pasting of the host Sentinels. "They decided to give him (shots with) his right foot, and he scored two goals in the first half.
Claire Jean Legare
1934 - 2012
MONCTON, NB - Claire Jean Legare, 77, of Moncton, NB; passed away peacefully at her residence, on Saturday, September 29th, 2012.
Born in Central Falls, Rhode Island, she was the daughter of the late Albert and Yvette (Moreau) Fournier.
Claire is survived by her sister Aline Crawford; two nephews Denis and David Murphy; and one great niece Klaudia Rogers.
Besides her parents, Claire is predeceased by her husband Leo E. Legare (2011)
Rita G. Dalpe
PAWTUCKET - Rita G. Dalpe, 91, of Pawtucket, passed away Sunday, September 30, 2012. She was the wife of the late William C. Dalpe.
Born in North Providence, she was the daughter of the late Edmond and Germaine (Chicoine) Batalon. Mrs. Dalpe was a lifelong resident of Pawtucket.
Ernesto Xavier DePina
CENTRAL FALLS - Ernesto "Ernie" Xavier DePina, 25, died September 29, 2012, at Rhode Island Hospital surrounded by family and friends.
He was born on May 10, 1987, in Bridgeport, Connecticut, the son of Jose Olimpio DePina and Margarida Xavier-DePina. He was the second eldest son of three boys and one girl.
He is survived by his parents, Jose Olimpio DePina and Margarida Xavier-DePina, his sister, Dilce Lawson, his brothers, Joseph and Danny DePina and his loving grand parents, aunts, uncles, nephews and cousins.
Elsie E. Conner
JOHNSTON - Elsie E. Conner, 93, died on September 30, 2012 at Morgan Health Center. She was born in Central Falls, RI. She was the daughter of the late Robert and Eva (Major) Conner. She worked at Pawtucket Memorial Hospital in the Maternity ward for 50 years until her retirement in 1999 where she was affectionately known as Red. She was a member of Smithfield Ave. Congregational Church.
She is survived by 1 nephew David Bardsley of New York, 1 niece Nancy O'Brien of Johnston, 1 great-niece, 1 great-great-niece and 1 great-great-nephew.
John F. Fanning
CUMBERLAND - John F. Fanning, 64, of Eddy Street, passed away Thursday in the Philip Hulitar Center, Providence.
Born in Pawtucket, he was the son of the late Francis J. and Madeline A. (Hunt) Fanning. He was a resident of Cumberland, and Craftsbury, VT.
John was a retired steamfitter for over 40 years, working out of Local 51, previously Local 476 of Rhode Island. He was an avid fisherman and outdoorsman.
He was a member of the Cumberland Beagle Club.
PAWTUCKET — Get out your red and green party wear and shine up those dancing shoes. The Times, in conjunction with Grupo Amigos Da Terceira, is hosting a "Jingle Mingle" to benefit the Times "Merry Christmas Fund."
The holiday dance event is scheduled for Saturday, Dec. 1, from 7 to 11 p.m. at the Community Center Grupo Amigos Da Terceira, Inc. at 55 Memorial Drive in Pawtucket. Music will be provided by Mega's DJ Music Productions., and the ticket price includes a buffet. A cash bar will also be available.
LINCOLN — There was a time in Rhode Island when parents of school age children needed to tune in radio personality Salty Brine for word on whether there would be school on wintery morning.
Those days are over and High School Principal Kevin J. McNamara now has a number of ways to get the word out about school events and weather including his school's Listserv option of directly emailing parents timely school updates.


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A very high quality G Series telephoto zoom lens with wide focal length range. Smooth, silent AF operation using high-torque SSM (Super Sonic wave Motor). G Series optics with Extra-low Dispersion (ED) glass elements for clear, sharp edge-to-edge description and reduced chromatic aberration. Circular aperture for beautiful defocus effects. Convenient operation with focus hold button and focus range limiter. More
Versatile, easy-to-handle telephoto zoom
Compact and lightweight, the SAL70300G combines extended zoom range with G Lens image quality. A 1.2m minimum focus distance makes it a good close-up performer too.
See the difference with G Lens
Renowned for their descriptive power, G Series lenses maintain excellent peripheral light characteristics and maximum contrast even at the edges of the frame.
Smooth defocusing
Instead of a standard polygon-shaped lens aperture, this lens features a 9-blade circular aperture for more natural, rounded defocusing or 'bokeh'.
Refined optical performance
ED (Extra-low Dispersion) glass elements provide superior contrast, resolution and colour fidelity throughout the image, even at large aperture settings.
Focus quickly and quietly
A rear focusing mechanism enables reduced minimum focusing distances and fast autofocus response. A built-in SSM (Super Sonicwave Motor) ensures silent operation.
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(1 of 1 customers found this review helpful)
Best for the A65
By Bill
from Midlands
About Me Semi-Professional
Best Uses
Comments about Sony 70-300mm f4.5-5.6 G SSM Lens:
I bought mine second hand six months ago and have used more than any of the other lenses I have for the A65. It is light enough to be an 'all day lens' snaps focus in good light almost instantly and gives a sharp, chromatic distortion free image over its whole range. My best wildlife and particularly semi macro ( technically micro) images I have are taken with this lens ( aided by the camera sensor stabilisation system). Colour is deeply saturated in good light and good in flat lighting. It is one of the few lens that I have access too that can image a sunset without flare. I have noticed that a UV filter reduces contrast and colour quality noticably so I now take it off just before shooting.The hood marks easily and the rubber zoom ring picks up dirt too easily.It is so much better than lesser zooms from Sony and others that it is well worth the cost new let alone second hand if you get one that has been looked after. The 24 meg sensor on the A65 crops well to 500mm equivalent up to 800asa giving an almost macro size with quality as well as for widlife in general. This may be a bit of a glowing assessment but it is worth it. Recommended
Bottom Line Yes, I would recommend this to a friend
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(6 of 6 customers found this review helpful)
Very pleased
By Ian from Berks
from West Berkshire
About Me Hobbyist/Enthusiast
Very pleased, crisp images, lightweight, ultra quiet focus. On a par with other Sony Lenses such as Carl Zeiss 16-80
(8 of 9 customers found this review helpful)
Best in it's price range!
By Churst
from Staines, Surrey
This lens performs incredibly well. The whole range is pretty sharp, maybe a slight drop at the longest end, but I'm more than happy with the real world results.I've been using this lens extensively. It's pretty impressive wide open, without having to worry about any unusable soft shots.It also deals with chromatic aberration, flare, ghosting really well.
(13 of 13 customers found this review helpful)
Quality optics, good value
By QDFB
from London, UK
This a high quality, light and compact lens with SSM focusing (i,e a near silent built-in motor) that works on full-frame Alpha mount camera like the Sony A900 as well as cropped format sensors. Stopped down a little, and between 70mm and 200mm this lens is very sharp. Close to 300mm it looses a little sharpness but is still very good.What I like the most about this lens, aside from its very good optical performance, is its light weight. However the trade-off is the plastic body which can mark quite easily if not treated carefully.An essential purchase for Alpha mount users wanting a versatile, powerful, high quality telephoto zoom for travel, nature and landscape work
Please Note: Used items are not eligible for Promotional or Cashback Offers.
Included Accessories: Front and rear caps, Carry case and lens hood
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Edwina A. Ward, graduate student in the Master of Arts in Cross-disciplinary Studies program in the Department of Multidisciplinary Studies (DMS) at the Graduate School of Humanities and Social Sciences (SHSS), is the Founder and Executive Director of Leaders Recognizing Leaders, a nonprofit organization dedicated to the recognition and enhancement of teen and young adult leadership and community service.
On May 26, the organization hosted the Leaders Awards Gala at the Carolina Golf Club in Margate. The keynote speaker was Larry Calderon, Ed.D., NSU's vice president for Community and Governmental Affairs. The gala recognized and honored youth leaders and the master of ceremonies was Marcus Washington, News Channel 5 reporter from Nashville, Tennessee.
Tags: Edwina A. Ward, Gala, Multidisciplinary, Teen Leaders


text: Leslie Reade | IBDB: The official source for Broadway Information IBDB: The official source for Broadway Information Official Broadway League sites: - sites - broadway.org broadwayleague.com broadwayfanclub.com kidsnightonbroadway.com stagespecs.org tonyawards.com Quick Search For: In This Category: All Show People/Org. Theatre Season Leslie Reade Writer Productions ProductionsDate of ProductionsThe Stranger[Play, Original] Written by Leslie Reade Feb 12, 1945 - Feb 24, 1945The Shatter'd Lamp[Play, Drama, Original] Written by Leslie Reade Mar 21, 1934 - Apr 1934 Find out where Leslie Reade and are credited together © 2001-2015, The Broadway League, All Rights Reserved. (Copyright and Disclaimer)


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This title is being sold in the downloadable VitalBook™ format.
This compact and concise monograph lays a foundation for the understanding of normal cardiovascular function. Students welcome the book as a practical partner or alternative to a more mechanistically oriented approach or an encyclopedic physiology text. Especially clear explanations, ample illustrations, clinical cases and problems, and chapter-opening learning objectives provide guidance for self-directed
learning and help fill the gap in many of today's abbreviated physiology blocks. A focus on well-established cardiovascular principles reflects recent, widely accepted research.
This title will only allow printing of 2 consecutive pages and copying of 2 consecutive pages at a time.
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Ohio Machine v Denver Outlaws
Brendan Mundorf of the Denver Outlaws tries to elude Chad Wiedmaier... News PhotoBrendan Mundorf,Denver,Denver Outlaws,Ducking,Horizontal,Lacrosse,Major League Lacrosse,Ohio Machine,Sport,Sports Authority Field at Mile High,Stadium,Third Quarter - Sport,USA,Waist UpPhotographer Justin EdmondsCollection: Getty Images Sport 2013 Getty ImagesDENVER, CO - JUNE 22: Brendan Mundorf #2 of the Denver Outlaws tries to elude Chad Wiedmaier #55 of the Ohio Machine during the third quarter at Sports Authority Field at Mile High on June 22, 2013 in Denver, Colorado. The Outlaws defeated the Machine 19-5 to improve to 8-0 on the season. (Photo by Justin Edmonds/Getty Images)


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Thank you to all the parents, faculty and students who contributed to making a festive fair on a gorgeous, sunny day. A special thank you to Mary and Joseph Manzare (parents, grade 4 and K3) who brought their extensive restaurant expertise to us this year. The food was extraordinary and the advice for moving forward invaluable!! For more of chef Joe's masterful cooking and menu planning visit one of his four restaurants—Globe, Zuppa, Hecho or Tres—you won't be disappointed!
Winter Fair Coordinators – Heather Mitchell, Jeni Vullings
Merchant Coordinator – Marisa Toriggino
Finance Coordinators – Peggy Duvette, Lisa Lehto
Kindergarten Primary Coordinator – Emily O'Keeffe
Kindergarten Games Coordinator – Jodi Jirsa
Kindergarten Cookie House Coordinator – Maureen Perry
Kindergarten Pocket People Coordinator – Sharon Campbell
Kindergarten 1 Coordinator – Stephanie Alston
Kindergarten 2 Coordinator – Wendy Walker
Kindergarten 3 Coordinator – Arezoo Fakouri
Grade 1: Fairy House – Monique Duncan
Grade 2: Crafts – Rhonda Emmert, Sabrina Nouri-Moosa, Gretchen Hillenbrand
Grade 3: Decorating – Moira Walsh and Cara Daniels
Grade 4: Hot Food – Mary and Joseph Manzare
Grade 5: Cake Walk – Paula McCabe
Grade 6: Sleeping Giant – Larry Doyle
Grade 7: Cashiering – Melinda Morrison
Grade 8: Set up/ Clean up – Paula McCabe and Justine Costerouse
Puppet Show – Early Childhood TeachersMath Games – Stacey Hubbard
High School Coordinators – Lisa Barry and Jessica Eicher
Musical Entertainment – Candace Tam
Curriculum Room – Erin Kemp
School Liaisons – Cory Powers, Lisa Sargent, Seraph White, Mitch Mitchell


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On sale early 500 sold out immediately! Rakuten ranking number one in mina shoulder tote bag boasts a track record to win is responding to the request of the person who purchased the birth in high quality leather material!
Are calculated fluffy cute gathers design at "classy & cute" reputation for friendly as it looks that are both fine and your job, you go, Mama bag is intact!
Skilled sewing bag plant world's largest leather market adopted top quality genuine leather and Japan's Department stores and apparel maker's strongest collaboration, in appearance!
Best out of the leather, grabbing the "mina-premium" M size will be selected by our 8 color waved everyone recalls the sweet, and grown-up glamorous aura to grant up to!
|Cowhide leather
|Metal fittings
|SA y size
|37.0 Cm width, height width 27.0 cm, Mati 15.0 cm
Hand with a 56.0 cm (h 24.0 cm) weight 850 g
|Magnetic button closure, in the Pocket, one (zip),
Two accessory pockets ( width 12 cm, 8 cm height 10 cm ), outside pocket two ( fasteners )
|Storage bags
|Country of origin
This product cannot be shipped to United States from the store.
Please contact the store for further information.


text:
We created Pandora to put the Music Genome Project directly in your hands
It's a new kind of radio –
stations that play only music you like
Die Krupps
The mid-'80s marked a fallow period for the band, and it was not until the 1992 release of the album One that it became clear exactly what Die Krupps had been doing over the preceding eight years -- basically, listening to Metallica and other metal innovators. Both One and its 1992 follow-up Metal for the Masses Part II -- A Tribute to Metallica found the group's signature sound augmented by metal guitars, which enabled Die Krupps to cross over to hard rock audiences while still maintaining its electronic music fanbase.
1993's Die Krupps Box, a three-disc box set, preceded the same year's release of The Final Option, which found Engler and Dorper joined by ex-Heathen guitarist Lee Altus and drummer Darren Minter. In 1994, a remix album, titled The Final Mixes, featured contributions from artists like the Sisters of Mercy's Andrew Eldritch, Nitzer Ebb's Julian Beeston, Gunshot, and Jim Martin, formerly of Faith No More. A year later, Odyssey of the Mind found the group moving even further from its electronic roots. Isolation, a collection of Odyssey of the Mind remixes and live tracks, appeared in 1996. ~ Jason Ankeny
Selected Discography
Track List: Too Much History
Track List: Metalmorphosis Of Die Krupps '81-'92
Track List: Odyssey Of The Mind
Track List: Rings Of Steel
Track List: A Tribute To Metallica
Similar Artists
2. Say your crushes name
3. Say a school day
4. Close your hand
5. Say your name
6. Open your hand and look at it
7. Post this to at least 15 other songs your crush will ask you out the day you said
working for life!


text:
The Blog
B&A Podcast: Good Manners, Bad Habits, 'Great Gatsby'
The Books & Arts Podcast is hosted by Philip Terzian
2:15 PM, Feb 19, 2014 • By TWS PODCAST
The WEEKLY STANDARD podcast, with literary editor Philip Terzian on the Books & Arts section of our February 24, 2014 issue.
This podcast can be downloaded here. Subscribe to THE WEEKLY STANDARD's iTunes podcast feed here.
Pieces in this week's Books and Arts section:
Sign up for The Weekly Standard Podcasts Updates


text:
The Summit Park Leadership Community engages Drury University students in a living-learning environment that focuses on the principles of leadership while incorporating the value of community service. Student teams form a year-long partnership with a local community agency and commit to 15 hours of community service a semester. The Summit experience earns two academic credit hours (one per a semester) AND through the emphasis on service-learning fulfills one Engaged Learning CORE graduation requirement.
It also counts towards Passport and completes two requirements on the Drury Leadership Certificate. Students reside in two-unit buildings located at the corner of Summit and Calhoun and residents get a dedicated parking lot directly behind the complex. The units include all major appliances including refrigerator, stove/oven, dishwasher and free in-unit washer & dryer!
Summit Park will cost $3,783 per a semester per a student for the 2013-2014 school year and this includes a 45 block meal plan with $130 Panther Bucks.
Learn more about the physical space and pricing from the Housing website.
The 2014-2015 Summit Park Apartment costs are $3,705 per a student and per a semester and this includes a 45 block plan with $130 Panther Bucks. Summit Park is the most affordable apartment option next year but there is an application process and participants must commit to implementing a service project (15 hours a semester) and taking a one-credit hour class each semester (the class meets once a month).
Download the 2016-2017 Application and more detailed information!
If you need assistance with developing a service project idea or have questions, please contact Courtney Swan at firstname.lastname@example.com or 417-873-7809.


text:
Published on: December 14, 2001
O.J. Simpson -- caught on a wiretap ordering the sex drug Ecstasy from a dealer -- is so addled by drugs that he has openly confessed: "I killed Nicole!"
That's the shocking story behind the December 4 raid on O.J.'s Miami home, when federal agents armed with a warrant searched the house for illegal drugs and stolen TV satellite equipment.
The issue that is on sale now also reveals all the details behind Simpson's sordid drugs-and-sex lifestyle, his threats against longtime girlfriend Christie Prody and her mother, the confession he blurted out in a jealous rage ... and more.


text:
The Harvard Young Democratic Club has maintained a record of "insufficient activities and faulty policy," David Z. Farbman '60, candidate for the presidency of the HYDC, charged last night in a debate with his opponent, Derek T. Winans '60, the other candidate for the presidency.
Winans replied that the Club has been attempting to vary activities, denying the existence of what Farbman termed a policy clique. "Our ideas and programs have been very successful this year," Winans claimed.
Read more in NewsDNA MEETING CANCELED
Want to keep up with breaking news? Get the latest, straight to your inbox.


text:
Farmstead Golf & Country Club, ClubView Course
- 88 Lawrence Rd, Lafayette, NJ 07848
- (973) 383-1666
- www.farmsteadgolf.com
|27 total holes at facility
|Green fees - $28 to $65 (estimate)
|Designed by Byron Phoebus
|Built in 1963
|Driving Range: Yes
|Public golf course
The ClubView Course at Farmstead Golf & Country Club is a 9-hole regulation length golf course in Lafayette, New Jersey. This medium-length layout has 3 sets of teeboxes for a fun, but challenging golfing experience. There are 2 other courses on this same property, the LakeView Course, and the Valley Course. Online tee times may be available at Farmstead Golf & Country Club or at nearby golf courses, usually offered at a discount from the normal rate.
|Course Rating
|Back Tees
|Golf Pro: Scott Pruden, PGA
|Course Superintendent: James Casazza
Note: In some cases there will be mistakes, even though the data is mostly right. If you stumble upon any inaccuracies, please point it out to us here.
Please login to add your review.


text:
If you are ready to find a dance workout dvd to lose weight with an affordable price and reliable quality. Well, this page is what you require actually.
To help you get the great bargain, we have chosen many kinds of DVD workout products which are best-selling on the market. They have a great fame for being ever-lasting, trendy, practical and delicate. Our company has become the leading DVD workout product manufacturer all over the world. Kill two birds with one stone, look delicate and be everlasting at the same time. With them, your exercise will be easier and much more colorful. Our products are the best selections for a healthy lifestyle. I think that you will fall in love with them at first sight.
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What are the Best Dance Workout DVD to Lose Weight
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Save this list of dance workout dvd to lose weight, and don't forget to share it with friends.


text:
RIC Listing Details
Mount Carmel Lutheran Church
515 SW Maplecrest Dr
Portland, OR 97219-6417
Telephone: 503-244-5143
Email address: email@example.com
Website: http://mtcarmellutheranpdx.com/
Affirmation of Welcome/Welcome Statement
Date of Affirmation: February 24, 2002
Affirmation approved/passed by: Council
Does affirmation include bisexual and transgender people? No
Where is the RIC certificate posted? Bulletin Board
Do outside signs have visible indicator of GLBT welcome? Yes
Publication(s) that regularly include a welcome statement: Bulletin Newsletter Website
Does the building have a gender-neutral bathroom? Yes
Worship style(s): Variety/Mix
Does or would the congregation have same-gender blessing services? No / Not Sure
Does adult education include gay and lesbian references and themes? Yes
Does adult education include bisexual and transgender references and themes? No
Does education include "out" LGBT leaders/speakers? No
Does youth education address LGBT references and themes? Yes
Are there GLBT-focused small groups? No
Are there GLBT-youth-focused small groups? No
Are "gay" and "lesbian" used in conversation? Sometimes
Are "bisexual" and "transgender" used in conversation? Sometimes
Are "gay" and "lesbian" used in worship? Sometimes
Are "bisexual" and "transgender" used in worship? Sometimes
Are there "out" gay and/or lesbian members? Yes
Are there "out" bisexual and/or transgender members? No
Are there "out" LGBT families and/or families with children? No
Are there "out" parents and/or family members of LGBT people? Yes
Are there current/former "out" LGBT pastors? No
Are there current/former "out" LGBT staff members? No
Are there current/former "out" LGBT people in leadership roles? Yes


text:
NEW YORK (AP) - The NFL will open the regular season next week with replacement officials and said it was prepared to use them "as much … as necessary" afterward.
Replacements will be on the field beginning Wednesday night when the Dallas Cowboys visit the New York Giants in the season opener, league executive Ray Anderson told the 32 teams in a memo. Negotiations are at a standstill between the NFL and the officials' union.
The NFL Referees Association was locked out in early June and talks on a new collective bargaining agreement have gone nowhere. Replacements have been used throughout the preseason, with mixed results.
In 2001, the NFL used replacements for the first week of the regular season before a contract was finalized. The speed of the game and the amount of time starters are on the field increase exponentially for real games, making the replacements' task more challenging.
Anderson, the NFL's executive vice president of football operations, told the clubs in a memo Wednesday that the replacements will work "as much of the regular season as necessary," adding that training with each crew will continue.
The NFL noted it has expanded the use of instant replay as an officiating tool this year to include all scoring plays and turnovers. Officiating supervisors will be on hand to assist the crews on game administration issues.
"We are not surprised, based on Ray Anderson's statements … that the NFL was not going to reach out to us," NFLRA spokesman Michael Arnold said. "However, this is consistent with the NFL's negotiating strategy which has been `take it or leave it and lock them out.' It now appears the NFL is willing to forego any attempt to reach a deal in the last seven days before opening night."
The NFL Players Association, which went through a 4 1/2- month lockout last year before settling on a new contract, expressed disappointment about the decision to use replacements.
Colts safety Antoine Bethea said there is a feeling of solidarity with the officials.
"They've got to do what they've got to do, and we were in a similar situation a little while ago," Bethea said. "So you can't fault those guys for doing what they have to do."
Anderson said the sides remain considerably apart on economic issues, including salary and retirement benefits. He also told the teams there is a substantial difference on operational issues.
"One of our key goals in this negotiation is to enhance our ability to recruit, train, and replace officials who are not performing adequately," Anderson said. "We believe that officials should be evaluated and performance issues addressed in the same way as players, coaches, club management and league staff. We have proposed several steps to accomplish this, including having a number of full-time officials and expanding the overall number of officials."
The NFL is offering to add three full officiating crews, increasing the total number of officials to 140. The NFLRA insists the compensation being offered with such an increase would reduce the officials' pay.
The league is proposing having seven officials _ one per position of referee, umpire, line judge, side judge, back judge, field judge, head linesman _ who would train, scout, handle communications, safety issues and rules interpretations year-round. Now, all NFL game officials are part-time employees, with outside jobs ranging from lawyers to teachers to business owners.
In response, the NFLRA has said it is not opposed to full-time officials "if they are fairly compensated."


text:
Irish Internet Radio and TV from Dublin, Ireland.
These are some photos of myself and the staff I worked with while I worked at the one and only Caesars Palace.
I worked there for over 12 years and met thousands of people
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text:
BPL Community Profile
Rick Dreher (halfturbo) - BPL Professional Member
You cannot send this user a personal message (PM) because they have not specified a PM email address yet.
All Forum Posts by Rick Dreher
Showing 1451 - 1460 of 1656 | Page: 1 ...137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 ...166
Re: CF Trekking poles--breakage characteristics
Hi Ted, Thanks very much for your comments and observations. Sudden shaft failure could certainly be a concern since we rely on our poles in dicy situations. It could be that CF is a more vulner...
Re: Tarptent Contrail
Henry, you never cease to amaze. Nice work!
Re: Montbell stretch bags
I've got an older model #5 and find the "comfortable" to be the minimum and imagine the "usable" would mean "no sleep." They've since altered the design and upgraded their down, so it could be t...
Re: cleaning trail running shoes?
Yup, the washer seems to work well. Be sure to remove the laces if using a top-loader!
New Olympii
Olympus unleashed a sack of new cameras for the biennial Photokina, including *four* new Stylus/Mju waterproof models. The Stylus 1000 will have 10-meg resolution, in case you're not filling up tho...
Re: golite hex 3
I've not had much luck finding well-placed, stout overhead branches. I hike in the Sierra, so other forest types might be more accommodating. The beauty of the overhead line is you have the full...
Re: Coleman Fyrestorm Ti Stove REVIEW
Hi Douglas, While Coleman has a photo on their website of a canister inverter stand compatible with Max stoves they've not, to my knowledge, proposed a Max adapter for the Fyrestorm. http://...
Re: Hex 3 modification for bugs, etc
I think so long as you're prepared to place items around the perimeter to hold the Tyvek beneath the netting, your scheme should work, although it seems possible you'll need a larger piece of Tyvek...
re. Photon Freedom
Hi Jonathan, I tag-teamed with Will on the Freedom spotlight review. Is there anything specific we didn't address that I might be able to help on? Personally, I'm impressed with the little Ph...
Re: Desolation Wilderness sleeping bag choice
Unless it cools off between now and then, the WM UL will be overkill. But you can always leave it unzipped! Right now, your quilt system would be fine. Also, they've been getting afternoon rains...
All Reader Reviews by Rick Dreher
Showing 1 - 7 of 7 | Page: 1
Mountain Gear
I've placed a few orders with Mountain Gear, going as far back as when they were based in Idaho, and they've responded flawlessly each time. I admire the breadth and high quality of their sele...
I have to put in a plug for these folks, with whom I've shopped on line and over the phone, and who also have a store in soggy Eugene, Oregon. They have a great backpacking and climbing selection f...
Recreational Equipment, Inc. (REI)
As another Seattle kid who loved few things more than pilgrammages to the Capitol Hill store, I still associate the smell of cresote with hiking gear. It's hard to imagine backpacking without REI. ...
Patagonia Micro Puff Pullover
I upgraded to the Micro Puff pullover after several seasons with the old Puffball pullover. Lighter, warmer, stuffs smaller--the Micro Puff is an all-around improvement to what was already a fine garm...
MSR Titan Kettle
Noting the shape isn't the most efficient for squeezing every btu from the stove, the MSR kettle remains a very good single-pot option. It packs nicely, works well with small to medium stoves, pours w...
MSR SimmerLite
I find the Whisperlite to be MSR's easiest liquid stove to use, and certainly the nicest to lug, bulk and weight-wise. Simmering performance is best with a light touch on the fuel pump--try using l...
Golite Hex 3
I've used a Hex 2, the 3's somewhat smaller brother, with good success for a few seasons. The quarters are a little snug for six-footers, but it's a minor concern. My main complaint is that the ventil...


text:
Dr. Cherner has an interest in the role of coexisting conditions such as stimulant drug (methamphetamine, MDMA) abuse and hepatitis C in the manifestation of HIV-associated neurocognitive disorders. Her current work focuses on genetically determined individual differences in vulnerability to brain dysfunction among methamphetamine users with HIV. The other focus of her research is in the area of cross-cultural neuropsychology, with a special interest in international neuroAIDS research and culturally competent assessment of cognitive abilities in Spanish speakers. She conducts her work within the HIV Neurobehavioral Research Program, where she is an investigator on a number of federally funded projects. She also directs the Interdisciplinary Research Fellowship in NeuroAIDS and participates in training and mentorship of pre- and postdoctoral researchers.
Dr. Cherner is a licensed clinical psychologist trained in adult neuropsychological assessment, with expertise in cross-cultural neuropsychological evaluation as well as neurobehavioral consequences of infectious disease and substance misuse.
Official Web Site of the University of California, San Diego.


text:
The following Linux news were published last week: the stable and final version of the Xfce 4.10 desktop environment has been released, bringing interesting features; Mark Shuttleworth talked to Ubuntu users on the usual "Ask Mark" session on IRC; The GIMP 2.8 image editor has been released and it brings lots of new features and improvements. Softpedia Linux Blog news includes articles about Wine 1.5.3, Tiny Core Linux 4.5.1, Tails 0.11, Linux kernel 3.4 RC5, Samba 3.6.5, Nautilus 3.5.1, Empathy 3.5.1, CrunchBang 11 R20120430, Tizen SDK 1.0, OpenBSD 5.1, Intel video driver 2.19, LibreOffice 3.5.3, Semplice Linux 3.0 Alpha 2, GNOME 3.5.1, Ubuntu GNOME Shell Remix 12.04, ArchBang 2012.05, Bauer-Puntu Linux 12.04, KDE SC 4.8.3, Calibre 0.8.50, Nvidia video driver 295.49, LPS Public 1.3.4, Vendetta Online 1.8.219, and much more. For this week we've also prepared a nice tutorial about how to upgrade Ubuntu 11.10 to Ubuntu 12.04 LTS, and an interesting review for the Mozilla Firefox 12.0 web browser. The weekly ends with the video clip of the week, the new and updated Linux distributions, and the development releases.
· Softpedia Linux Blog: Ubuntu Wikipedia Lens for Unity, Ubuntu Cloud Summit: 8 May 2012, and more...
· Tutorial of the Week: How to Upgrade Ubuntu 11.10 to Ubuntu 12.04 LTS
· Review of the Week: Mozilla Firefox 12.0
· Video Clip of the Week: GIMP 2.8
· New Distributions: Salix OS MATE Live 13.37 RC1 and Saluki 021
· Distributions Updated Last Week: ArchBang 2012.05, Bauer-Puntu Linux 12.04, SlimPup 3.6, and more...
· Development Releases: CrunchBang Linux 11 R20120430, Semplice Linux 3.0 Alpha 2, and more...
· On April 28th, after more than one year of hard work, the Xfce development team proudly announced the immediate availability for download of the Xfce 4.10 desktop environment. Xfce 4.10 supersedes the previous Xfce 4.8 version found on major Linux distributions, and it comes with improved user experience and a polished desktop interface. Read more about it here.
· On May 1st, Mark Shuttleworth was present at the "Ask Mark" IRC session event to talk with the Ubuntu users, were he answered a few interesting questions. The "Ask Mark" session was part of the Ubuntu Open Week event, which took place between May 2nd and May 4th on IRC. Softpedia published some of the most important (in our opinion) ones, asked by various users who attended the "Ask Mark" event on IRC on May 1st. Read more about it here.
· On March 3rd, the GIMP development team unleashed the final version of the highly anticipated GIMP 2.8 image editor software. As expected, GIMP 2.8 brings numerous changes, including new and updated features, bugfixes, as well as stability improvements. GIMP 2.8 comes with amazing new features, such as the highly acclaimed single window mode, layer groups, full on-canvas text editing capabilities, and many more. Read more about it here.
· Wine 1.5.3 Has Graphics Bounds Tracking
· Tiny Core Linux 4.5.1 Final Available for Download
· Tails 0.11 Has Linux Kernel 3.2.15
· Download Linux Kernel 3.4 Release Candidate 5
· Introducing Ubuntu Wikipedia Lens for Unity
· Samba 3.6.5 Fixes Security Issue
· Ubuntu Cloud Summit: 8 May 2012
· Nautilus 3.5.1 Available for Download
· Ubuntu 12.10 Is Now Open for Development
· Empathy 3.5.1 Is Available for Download
· GTK+ 3.4.0 Available for Download
· Ubuntu Open Week 2012: May 2nd - May 4th
· Calibre Plugin of the Week: Quality Check
· CrunchBang 11 R20120430 Available for Download
· System76 Sells Ubuntu 12.04 LTS Notebooks
· The Tizen SDK Available for Linux
· New Kernel Vulnerabilities Affect Ubuntu 11.10
· Fedora 18 Will Be Named Spherical Cow
· Ubuntu One Available on Nokia N9
· OpenBSD 5.1 Officially Released
· Intel 2.19 Video Driver for Linux Released
· LibreOffice 3.5.3 Is Now Available for Download
· Semplice Linux 3.0 Alpha 2 Available for Download
· GNOME 3.5.1 Development Release Is Here
· Introducing Ubuntu 12.04 With GNOME Shell
· ArchBang 2012.05 Has New Default Theme
· Bauer-Puntu Linux 12.04 Is A Tribute to Anonymous
· Trine 2 Coming to Ubuntu Software Center and Desura
· Ubuntu 12.10 Won't Have non-PAE Kernel
· KDE SC 4.8.3 Is Now Available for Download
· Calibre 0.8.50 Improves Support for KF8 MOBI Format
· Nvidia 295.49 Fixes OpenGL Regression for GeForce 6 and 7
· Linux Format Magazine Pulled Off Barnes & Noble's Shelves
· Diablo III Unlikely to Appear on Linux
· Thunderbird 12 Officially Lands in Ubuntu
· LPS Public 1.3.4 Has Firefox 10.0.4 ESR
· Vendetta Online 1.8.219 Improves Login Time
Tutorial of the Week: How to Upgrade Ubuntu 11.10 to Ubuntu 12.04 LTS
· The following tutorial will teach Ubuntu 11.10 (Oneiric Ocelot) users how to upgrade their operating system to the brand-new Ubuntu 12.04 LTS (Precise Pangolin) release.
This tutorial is addressed to Ubuntu 11.10 users who just want to upgrade their current installation to Ubuntu 12.04 LTS and don't know how. It will make things very simple for you, but if you get stuck somewhere in the middle of the installation and you need help, do not hesitate to use our commenting system at the end of the article!
Read the complete tutorial here.
Review of the Week: Mozilla Firefox 12.0
· A year ago the community was redding itself for the new and improved Firefox 4.0, but the users didn't just receive a new browser, but also a new roadmap for future releases.
The best feature of Firefox, the multitude of add-ons, is also its greatest problem. The fact of the matter is that some features should be available by default and not introduced with third party extensions. In theory, add-ons sound great, but they can also slow down the browser and even the operating system, especially when there are a lot of them, like in the case of a power user.
Read the entire review here.
Video Clip of the Week: GIMP 2.8
· For this week we've posted a 720p HD video clip that showcases the new features of the GIMP 2.8 image editor. The video has 8 minutes and 29 seconds, and it was posted by LinuxSpatry.
· Salix OS MATE Live 13.37 RC1
Distributions Updated Last Week:
· Ubuntu GNOME Shell Remix 12.04
· CrunchBang Linux 11 R20120430
See you again at the end of next week for another issue of Softpedia Linux Weekly.