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Explore openwork in this crocheted cover-up by designer Tammy Hildebrand, originally published in Interweave Crochet Summer 2012.
About Knitting Daily TV with Vickie Howell
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Knitting Daily TV with Vickie Howell is an exciting needle crafts how-to program on public television covering everything from knitting and crochet to stitching, felting, and spinning. The show guides viewers in learning to make fun yet smart one-of-a-kind designs using the latest products in yarn and fiber. Download free patterns, meet trendsetting knit and crochet designers, and improve or learn new skills and techniques.
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This property allows you to book online with a credit card. After submitting a reservation request, the owner or manager has 24 hours to accept, at which time your card will be charged and you will receive an email confirmation
Recent Other Bradenton Properties reviews
"This home is a great bang for the buck in the sarasota area. Less than 10 miles to the Bradenton beaches and less than 20 to Siesta Key (AMAZING SAND) and Sarasota beaches. Flea market is very close as well. The property is awesome and has no shortage of room. There is an abundance of wildlife and you're right on the slow moving river. We had 12 people stay comfortably. The staff was great to work with and provided excellent prompt service to a small maintenance item We encountered. Master edition is excellent especially the bathroom. Kitchen is a little small and could use a little updating but is fully functional. solid 4 star endorsement."Guest: Clint Date of Stay: April 2015 Review Submitted: May 14, 2015View listing
"Theres no need to travel outside the USA for beautiful blue water, serenity, and a tropical oasis. My family of six adults and 3 grand dogs arrived on vacation ready to relax. Casa Encantada is the medicine for stress! It's everything you see on Capt Julie's description and so much more! The smallest details await in this estate! Renting the pontoon in this package for the week made traveling out to all the destinations suggested by the owner even more memorable. Manatee, dolphins, sunsets to die for, and sea shells galore. This was absolutely our most favorite family vacation! Oh, and the dogs were spoiled rotten! Thanks Capt for all your suggestions. Your Casa is fabulous!"Guest: Lynne B. Date of Stay: May 2015 Review Submitted: June 20, 2015View listing
"Great Location! Just a short walk to historic downtown, great restaurants and the Bradenton Riverwalk. very clean comfortable accommodations. Robert the owner is very involved in the community and is a great source of information for places to go and things to do. The owners are very responsive to any special requirements. Just a short drive to the gulf beaches. We have rented this unit for two consecutive winters and have found it to be a great get away from the cold Maine winters. Conveniently located to everything."Guest: Mark Date of Stay: December 2014 Review Submitted: June 20, 2015View listing
"Must park in visitor spot on other side of parking lot. Husband's car towed at 2 a.m. He talked w/ tow-truck driver & went upstairs to get key to vehicle. Before he came back downstairs (17 steps), the driver had taken the car. It cost us $250 and about and hour to get our car back. This was the first day of our vacation. Apt. was clean & neat. Insufficient lighting in LR & both BR's. Faucet broken in M. Bath. Still worked but top part missing & difficult to use. Plumber fixed kitchen faucet by mistake (didn't realize that faucet needed repair). LR sofa's too soft. Beds nice. Shower curtain in M. bath mildewed. Informed owner. Not replaced while we were there. Lake in back of apt nice. Sidewalk around lake."Guest: Medora M. Date of Stay: December 2014 Review Submitted: January 3, 2015View listing
Featured Destinations: Dauphin Island, Isle of Palms, Bald Head Island, Destin Condo Rentals

subset: commoncrawl


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Membership in the Ewing Family Association is open to all persons with the surname of Ewing or who are descended from anyone with that surname; to anyone who is, or has been, the spouse of such a person; and to anyone who otherwise supports the Association's purposes.
Benefits of Membership
Participation: Members are encouraged to attend biennial Gatherings at historically significant locations around the United States. We expect to have a presence at Scottish heritage events, such as Highland games, where we expect to represent and support Clan Ewing. Members are invited to attend EFA meetings to help plan and vote on new initiatives. Members are welcome to participate in our online discussion forum and on our Facebook page.
Journal: Membership in the Ewing Family Association includes a subscription to its Journal, a quarterly publication providing material of interest to people having a Ewing heritage or an interest in the Association's activities. Members may elect to receive electronic (PDF) versions of the Journal rather than printed versions; electronic versions are delivered more quickly and are in color.
Individual Memberships
The Membership Form should be completed online and submitted electronically. Dues are $25 per year.
Individuals may join at any time during a calendar year. Those who join prior to the end of July will be considered members for the current calendar year and will receive all of the issues of the Journal for the current calendar year. Those who join after the end of July but before the end of October will be considered as members for the following calendar year and will, as a courtesy, receive a copy of the current year's November issue of the Journal. Those who join after the end of October will be considered as members for the following calendar year.
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Library Memberships are available at $20 per calendar year. Members may sponsor Libraries Memberships by submitting a Regular Membership Form identifying the libraries.
Libraries or other institutions may directly join and will receive all issues of the Journal for the calendar year in which they join. If they join after the end of October, they will be considered as members for the following year but receive all issues of the Journal. To join, they should complete a Membership Form indicating the information for a contact person.
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Renewal Reminders are sent in mid-October and should be returned, with payment, by the end of the year. We are also happy to accept renewals through the online Membership Form. Members not renewing by the beginning of March in the next calendar year will be considered "delinquent" and dropped from the roll of active members. If delinquent members later pay their dues, they will be reinstated and receive copies of the Journal issues published during the calendar year in which they become reinstated.
Renewal Reminders will identify the member's Gift Memberships and any Library Memberships they are sponsoring. The recipients of Gift Memberships and sponsored Library Memberships will not be sent Renewal Reminders; it is up to the gifting/sponsoring Regular Member to renew these memberships.
The Association welcomes additional contributions to help support its activities and projects. Unrestricted contributions are preferred, but you may restrict your donation to be used for specific activities, for example to pay for Y-DNA testing of those who cannot pay the test fee themselves or to support other specific projects or activities.
Donations to the Association are generally tax-deductible in the US, as we are a 501(c)3 organization.


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If you've ever wanted to see card tricks, sleight of hand, scams and cheats up close, this half-price offer gives you the chance.
For £27.50, catch "The Card Shark Show" at London's May Fair Theatre, where Magic Circle member Steve Truglia performs live to share his secrets with the audience and tell stories about the craft, its history and how different illusions originated.
Unreserved seating normally costs £50 plus a £5 fee, but the offer price of £27.50 already includes a per-ticket booking levy, so there are no additional charges to pay. Choose from the following performances:
We have also negotiated an offer for Premium tickets in the front three rows of the theatre. Usually £65, these are now £33 each.
Book by 23 January.
Please go to your email and confirm your subscription.


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by Frank Leonardo.
Here are photos of some of the fish we shot up at the St. Lawrence . We could not fish during the day because it was too cloudy and windy. It calmed down at night, but we did not do well the first night. The only thing we saw was a police boat for a hour or so. They had the lights going and everything. (more…)


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Item #: KINP5
PRO KENNEX Kinetic Pro 5G Racquets
Our staff has not reviewed this product yet.
One of the most arm friendly racquets on the market, the Pro Kennex Kinetic Pro 5G features the technology that is widely regarded for its ability to mitigate tennis elbow. Studied extensively at MIT, the Kinetic system, a material housed in 100 chambers around the racquet head, actively reacts and moves during the tennis swing. In action, the kinetic material moves towards the trailing edge during the swing, and then jumps forward during the impact phase, essentially providing extra weight at impact. The increased stability and power from this motion also helps to provide one of the absolute best methods of fighting tennis elbow, as the kinetic material is able to greatly absorb both shock and vibration by being allowed to freely move. The Kinetic Pro 5G is an excellent racquet combining comfort, control, and power. Weighing in at a moderate 11.1 ounces unstrung, this racquet provides plenty of heft for stronger players, while the midplus headsize and head light balance provide a bit of extra pop and maneuverability. As one of the most control oriented of the Kinetic line, the thinner beam offers tremendous feel despite the extremely comfortable impact. A versatile all around racquet, this one is recommended for solid intermediate to advanced players with medium to longer swings searching for comfort without sacrificing playability.
For more information on choosing a racquet, please see the Tennis Express Buyer's Guide.
|Head Size:
|100 sq. in MP
|27 inches
|Strung — 11.6 oz Unstrung — 11 oz
|55-68 pounds
|9 Pts Head Light
|Beam Width:
|22 mm Straight Beam
|100% Ultra High Modulus Graphite with kinetic System Technology
|Grips Size:
|1 2 3 4 5
|Grip Type:
|Perforated Cushion Grip
|Power Level:
|String Pattern:
16 Mains / 20 Crosses
Mains skip: 8T,8H
One Piece
No shared holes
|Swing Speed:
|Swing Weight:
User: k johnson, fl
Kinetic Pro 5G racquets
User: Barry chan, New York
Overall, it is ok. My tennis elbow seems no happening to me after playing. One thing I want to mention that the head of racquet is little bit small, I do not know why. It should be 100 already. Thats why when I hit the ball, I need to look at the ball. I install Wilson natural string, it is very powerful when I serve the ball. I do not need to put too much power from my arm then the ball goes fast.
Great Racquet
User: Matt Ritchie, SC
Hope they never discontinue...
Great help
User: mary hoot, ohio
Years ago I had tennis elbow and read online about this racquet being good for that. I got one about 12 years ago and have never had tennis elbow again. I just got another with a smaller grip. It is wonderful, I have it strung a bit on the looser side for good control.
Does what it says
User: John Westerfield, VA
I purchased this racquet after reading about its vibration dampening ability and its kindness to tennis elbows. Ive used it about a month and can say there is certainly less vibration and feels better to the elbow. Well see how it performs long-term, but so far very happy.
Kinetic Pro 5G
User: Keith Brennaman, Nevada
I have purchased 2 racquets in the past thirty days from you. Both have arrived in a very timely manner and both were strung with excellent string. My favorite is the ashaway zyex mono gut. You guys are quick and professional and most importantly your prices are competitive or better than anywhere else i looked.
Feels Heavier but definitely good for your tennis elbow
User: KaiserM, VA
I started playing tennis with a cheap raquet from walmart and paid the price. Only after a few weeks of playing i started having pain in my right elbow and it only started getting worse. After doing some research, chatting with customer service people at tennis express, i decided to go with this raquet which was the right decision. This raquet is a little heavier, not so good for service but great for backhand and ok for forehand shots with no or very little vibrations. my pain has subsided after playing with this raquet. i recommend this for anyone with tennis elbow issues.
Pro Kennex 5G
User: Gabe, La
I purchased this racquet after extensive research. I have been experiencing some elbow and shoulder issues after playing. I'm also not vey happy with the racquets I have been playing with. I demoed several racquets from a local shop and was not happy with them either. I like the reviews I was seeing on the Pro Kennex 5G and decided to try it. Because it is an older model, I couldn't find any to demo and since the price was only $119, I decided to order one. I have been very pleased with how it has played. I have seen some consistency come back into my game. So far, no I have not had any issues with my elbow and shoulder. I have since ordered a second one.
Great racket and great service!
User: Kristen, FL
I ordered this racket and received it just a few days after ordering. It's a phenomenal product that I have not once regretted buying! Thanks very much!
Wilson 90
User: NITH, tx
I've always played with the old/new Wilson n-k-blx90 for control, but it killed my elbow. Now I'm playing with the 5G because it's elbow friendly.
kennex 5G
User: mike, oh
I tried the 5g due to problems with tennis elbow. I am 3.5-4.0 and play 3-4 times per week. Had been using Wilson KFactor 90 which was stiff, but featured the control that I was after. Unfortunately it was like hitting with a board and my elbow suffered after several months. Now after playing with the 5G my elbow is fine and doesn't require a brace during play or ice afterwards. I do like the feel, weight and control of the 5G and have continued to try other racquets, but like the 5G better than any other racquet so far.
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Duck Basketball: Altman gets first 2011 commit
Portland, OR -- Dana Altman has landed his first recruit for 2011 in the form of Westview's 6-foot-9 Austin Kuemper.
Kuemper averaged 12.9 points and 8.1 rebounds per game last season and shot 57-percent from the field, as well as 83-percent from the free throw line.
He is a versatile player who can play a variety of positions in Altman's offense.


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Lost Without Jesus
February 7 | Taken from a message by Adrian Rogers
Sometimes when I am interviewed by a news organization, I get the impression that the interviewer is trying to put me in a hot box or make me say something I will regret.
The interviewer will eventually ask me, "Do you think a Jew without Jesus is lost?" If I said yes, then number one, I am viewed as a racist or a bigot. Isn't that right? If I say, "No, I believe he's saved," then I have absolutely dishonored the Lord Jesus Christ who died for the sins of all people.
Do you know what I have learned to say? "Friend, I believe that one of my own children without Jesus is lost. It doesn't matter whether he's a Jew or a Gentile."
You see, God demands absolute perfection and none of us can provide. Romans 3:23-26 says, "For all have sinned, and come short of the glory of God; Being justified freely by His grace through the redemption that is in Christ Jesus: Whom God hath set forth to be a propitiation through faith in His blood, to declare His righteousness for the remission of sins that are past, through the forbearance of God; To declare, I say, at this time His righteousness: that He might be just, and the justifier of him which believeth in Jesus."
We need the gospel. We need the righteousness of God that comes by believing on the Lord Jesus Christ.


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Email: email@example.com
Can't find yourself? Submit your profile to the Huntsman School Alumni and Friends Directory.
BS, American Studies, Utah State University, 1990
MBA, Harvard University, 1995
Executive Leadership Speaker - February 14, 2007
Greg Larson is a 1990 alumnus of USU and 1995 Harvard Business School alumnus. When he left USU he went to work for Ford Motor in Detroit. While he was at Ford, he applied to Harvard and was accepted as the Ford Fellow. Ford paid his tuition with the understanding that he would return to the company after he finished his MBA. Instead of returning to Ford, he spent several years with Wall Street firms and private equity shops.
He also possesses a strong entrepreneurial management and operational background. He founded and was CEO of an IT services company financed by two well-respected institutional capital providers. He returned to Utah a few years ago to co-found a private equity firm, Ridgeview Capital, which has become a preeminent merchant bank, providing private equity capital and investment banking services to Mountain West companies.
Mr. Larson has been recognized as one of Utah Business Magazine's 2006 Forty Under 40. He currently sits on the boards of Metro Waste, Koster's Finance and Wasatch West Distribution.
He is married to Julianne, who is also a 1991 alumnus in art and a former Sunburst dancer. Mr. and Mrs. Larson reside in Fruit Heights, Utah.
AACSB Accredited
Shingo Institute
Partners In Business
3500 Old Main Hill
Logan, UT 84322-3500
Phone: 435.797.2272
Fax: 435.797.2399
Email: email@example.com


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Harvey J. Grill, PhD, received his doctorate in 1974 from New York University, in physiological psychology. He did his postdoctoral work in behavioral neuroscience at Rockefeller University. He came to Penn in 1977 and is a professor of psychology and neuroscience.
His work focuses on the neural bases of obesity and anorexia, with the following research themes:
1. Delineate the contribution of neural circuits and transmitter systems contained within forebrain, midbrain and hindbrain as they combine to contribute to a distributed control of energy intake and energy expenditure.
2. Examine the distributed neural control of thermoregulation and fever with an eye toward gaining insight into their underlying autonomic organization as this informs the neurology of energy expenditure.
3. Develop new paradigms to distinguishing the neural circuits controlling the size of individual meals from those regulating energy balance in the longer term. In so doing examine interactions between gastointestinal signal processing and the action of hormones like leptin and ghrlein whose levels vary with energy
4. Define the oral motor and gastrointestinal actions of anorexic agents [e.g., neuropeptide and monoamines] and the location of receptors mediating these effects.
5. Define how metabolic state alters or modulates behavioral and autonomic output systems.
6. Develop animal models for pharmacological and surgical treatments for the treatment of obesity and for insufficient feeding in humans.
Psychology Graduate Group; Neuroscience Graduate Group
Grill, HJ. (2010) Leptin and the systems neuroscience of meal size control. Frontiers in Neuroendocrinology, 31(1):61-78.
Skibicka KP and Grill HJ. (2009) Hypothalamic and Hindbrain Melanocortin Receptors Contribute to the feeding, Thermogenic and Cardiovascular Action of Melanocortins. Endocrinology. 2009 Nov 150(11).
Hayes MR, Bradley L, Grill HJ. (2009) Endogenous hindbrain glucagon-like peptide-1 receptor activation contributes to the control of food intake by mediating gastric satiation signaling. Endocrinology. 2009 Jun;150(6):2654-9. Epub 2009 Mar 5.
Skibicka KP, Alhadeff AL, Grill HJ. (2009) Hindbrain cocaine- and amphetamine-regulated transcript induces hypothermia mediated by GLP-1 receptors. J Neurosci. 2009 May 27;29(21):6973-81.
Grill HJ, Hayes MR. (2009) The nucleus tractus solitarius: a portal for visceral afferent signal processing, energy status assessment and integration of their combined effects on food intake. Int J Obes (Lond). 2009 Apr;33 Suppl 1:S11-5.
Hayes MR, Skibicka KP, Bence KK, Grill HJ. (2009) Dorsal hindbrain AMP-Kinase as an intracellular mediator of energy balance. Endocrinology. 2009 May;150(5):2175-82, 2008 Dec (Epub)
Skibicka KP, Grill HJ. (2009) Hindbrain leptin stimulation induces anorexia and hyperthermia mediated by hindbrain melanocortin receptors. Endocrinology 2009 April;150(4):1705-11, 2008 Dec (Epub)
Nautiyal KM, Dailey M, Brito N, Brito MN, Harris RB, Bartness TJ, Grill HJ. (2008) Energetic responses to cold temperatures in rats lacking forebrain-caudal brain stem connections. Am J Physiol Regul Integr Comp Physiol. 2008 Sep;295(3):R789-98
Hayes MR, Skibicka KP, Grill HJ (2008) Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain GLP-1 receptor stimulation. Endocrinology. 2008 Aug;149(8):4059-68
Skibicka KP, Grill HJ. (2008) Energetic responses are triggered by caudal brainstem melanocortin receptor stimulation and mediated by local sympathetic effector circuits. Endocrinology. 2008 Jul;149(7):3605-16
Huo L, Gamber KM, Grill HJ, Bjorbaek C. (2008) Divergent leptin signaling in proglucagon neurons of the nucleus of the solitary tract in mice and rats. Endocrinology. 2008 Feb; 149(2):492-7.
Grill HJ, Skibicka KP, Hayes MR. (2007). Imaging obesity: fMRI, food reward, and feeding. Cell Metab. 2007 Dec; 6(6): 423-5.
Harris RB, Bartness TJ, Grill HJ. (2007) Leptin responsiveness in chronically decerebrate rats. Endocrinology. 2007 Oct; 148(10):4623-33.
Huo L, Maeng L, Bjorbaek C, Grill HJ. (2007) Leptin and the control of food intake: neurons in the nucleus of the solitary tract (NTS) are activated by both gastric distension and leptin. Endocrinology. 2007 Feb 22


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The head of the United Nations International Atomic Energy Agency (IAEA), Yukiya Amano, stressed the need for both Iran and the Democratic People's Republic of Korea (DPRK) to cooperate in resolving outstanding issues regarding their nuclear activities. IAEA
Broadcast-quality video for UNifeed stories is available online for two weeks. Should you wish to request older material, please contact the agency source of the material. For UNTV or peacekeeping stories, please contact the UN Video Library. You can contact Video Library by emailing to firstname.lastname@example.com.
© 2015 UNifeed.


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- » Focus and Scope
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Focus and Scope
Network and Communication Technologies publishes original research, applied, and educational articles in all areas of communications and network. The scopes of the journal include, but are not limited to, the following fields:
- Wireless system architectures
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Section Policies
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Peer Review Process
The journal uses double-blind system for peer-review; both reviewers and authors' identities remain anonymous. The paper will be peer-reviewed by three experts; two reviewers from outside and one editor from the journal typically involve in reviewing a submission.
Publication Frequency
2013 Semiannual, published in June and December
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This journal provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge.
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Did you know that Georgia residents served by Atlanta Gas Light can shop for natural gas just like you shop for a new TV or mobile phone?
Atlanta Gas Light customers may be able to save on their energy bill by choosing a company likeConstellation or one of its subsidiaries.
Constellation provides residential natural gas plans to Atlanta Gas Light customers. Our plans include:
Have your current utility bill handy? You're on your way to controlling your energy cost. Compare Our Rates Now!
Constellation knows that natural gas is an important part of everyday life in homes across North America. And with natural gas rates steadily rising, consumers are paying more attention to their how much they use, and how much they pay. In fact, a one-penny difference in your rate could add up to $30 to your bill over the course of a year!
Here are some quick facts about Constellation's offers in Georgia:


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Formula One News » Monaco Grand Prix 2013 – Massa crash due to suspension failure Posted on 28/05/2013
Ferrari have revealed that Felipe Massa crashed out of the 2013 F1 Monaco Grand Prix due to suspension failure.
Massa was taken to the hospital after his hard impact but was later released that evening.
A Ferrari statement read "The findings validated the first impressions of the engineers, confirming that the accident was caused by an element of the front left suspension breaking.
"With all the required inspections completed to analyse what happened at the Monegasque circuit, the car assembly department can now start work in preparing the car for the Canadian Grand Prix."
Team Principal Stefano Domenicali added: "The best news to come out of the Monaco weekend is that Felipe is fine. Two big accidents, just over twenty four hours apart and all he has to show for it is a bit of muscle pain. Fortunately there were no other injuries."


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Tuesday, October 16, 2012
© Copyright 2015 Gwinnett Daily Post
WASHINGTON (AP) — More than 56 million Social Security recipients will see their monthly payments go up by 1.7 percent next year.
The increase, which starts in January, is tied to a measure of inflation released Tuesday. It shows that inflation has been relatively low over the past year, despite the recent surge in gas prices, resulting in one of the smallest increases in Social Security payments since automatic adjustments were adopted in 1975.
Social Security payments for retired workers average $1,237 a month, or about $14,800 a year. A 1.7 percent increase will amount to about $21 a month, or $252 a year, on average.
Social Security recipients received a 3.6 percent increase in benefits this year after getting none the previous two years.
About 8 million people who receive Supplemental Security Income will also receive the cost-of-living adjustment, or COLA, meaning the announcement will affect about 1 in 5 U.S. residents.
Social Security also provides benefits to millions of disabled workers, spouses, widows, widowers and children.
"The annual COLA is critically important to the financial security of the (56) million Americans receiving Social Security benefits today," said Nancy LeaMond, AARP's executive vice president. "Amid rising costs for food, utilities and health care and continued economic uncertainty, the COLA helps millions of older Americans maintain their standard of living, keeping many out of poverty."
The amount of wages subjected to Social Security taxes is going up, too. Social Security is supported by a 12.4 percent tax on wages up to $110,100. That threshold will increase to $113,700 next year, resulting in higher taxes for nearly 10 million workers and their employers, according to the Social Security Administration.
Half the tax is paid by workers and the other half is paid by employers. Congress and President Barack Obama reduced the share paid by workers from 6.2 percent to 4.2 percent for 2011 and 2012. The temporary cut, however, is due to expire at the end of the year.
Some of next year's COLA could be wiped out by higher Medicare premiums, which are deducted from Social Security payments. The Medicare Part B premium, which covers doctor visits, is expected to rise by about $7 per month for 2013, according to government projections.
The premium is currently $99.90 a month for most seniors. Medicare is expected to announce the premium for 2013 in the coming weeks.
"If seniors are getting a low COLA, much of their increase will go to pay off their Medicare Part B premium," said Mary Johnson, a policy analyst at The Senior Citizens League.
By law, the increase in benefits is based on the Consumer Price Index for Urban Wage Earners and Clerical Workers, or CPI-W, a broad measure of consumer prices generated by the Bureau of Labor Statistics. It measures price changes for food, housing, clothing, transportation, energy, medical care, recreation and education.
Over the past year, housing costs have gone up 1.4 percent but home energy costs have dropped by 3.8 percent, according to the CPI-W. Medical costs, which tend to hit seniors harder than younger adults, have increased by 4.4 percent.
Gasoline prices have gone up by 6.8 percent, but much of that increase happened in the past month, so it is not fully reflected in the COLA for Social Security.
To calculate the COLA, the Social Security Administration compares the average price index for July, August and September with the price index for the same three months in the previous year. The price index for September — the final piece of the puzzle — was released Tuesday.
If consumer prices increase from year to year, Social Security recipients automatically get higher payments, starting the following January. If prices drop, the payments stay the same, as they did in 2010 and 2011.
Since 1975, the annual COLA has averaged 4.2 percent. Only five times has it been below 2 percent, including the two times it was zero. Before 1975, it took an act of Congress to increase Social Security payments.
Most older Americans rely on Social Security for a majority of their incomes, according to the Social Security Administration. Over the past decade, the COLA has helped increase incomes for seniors, even as incomes have dropped for younger workers.
From 2001 to 2011, the median income for all U.S. households fell by 6.6 percent, when inflation was taken into account, according to census data. But the median income for households headed by someone 65 or older rose by 13 percent.
More like this story
- Report: Social Security will go broke sooner than expected ( March 24, 2005 )
- Retirees to see boost in checks ( October 23, 2005 )
- Medicare participants face 3 percent increase in monthly premiums ( October 3, 2007 )
- Social Security frozen again ( October 11, 2010 )
- Seniors get short end of the stick ( August 29, 2009 )
kevin 2 years, 12 months ago
And why are seniors not protesting the 1.7% increase in the rate of inflation? Have seniors become senile as well? Do seniors shop and see how high prices for everything has gone up? Two tiny increases in 4 years has been given to seniors by Obama. Medicare premiums alone have risen over 1.7% and will double in the next 2 years. This should be a "no brainer" for seniors to attack the Obama administration and its policies. Old folks getting screwed again. Do you also notice that the Liberal AARP hasn't said a word about this lousy Obama record of raises for seniors in their publications?
kevin 2 years, 12 months ago
Quote:"The annual COLA is critically important to the financial security of the (56) million Americans receiving Social Security benefits today," said Nancy LeaMond, AARP's executive vice president. "Amid rising costs for food, utilities and health care and continued economic uncertainty, the COLA helps millions of older Americans maintain their standard of living, keeping many out of poverty."
This is a slap in the face for every senior. Over half don't collect the "average" SS check listed in this article. Some will see about $10. a month increase! Too bad the Obama admin didn't include all things in their calculation!!! The 3 things alone that are mentioned here jumped well over 1.7% in the past year, thanks in part to gas prices. How stupid do they think seniors are? Like this 1.7% is going to keep them out of poverty. What a joke.


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Hundreds say aloha to Aloha DalireUPDATED 7:40 PM HST Aug 20, 2014
Hundreds gathered to say aloha to a woman who has left behind a legacy of hula.Video Transcript
Hundreds gathered to say ALOHA to a woman who has left behind a legacy of hula This afternoon it was a time to celebrate the life of Kumu Hula Aloha Dalire. Hawaiian Memorial Park chapel sat filled with flowers today... Giving off the scent of Hawaii.. The scent of aloha.. As from people all over the islands shared THEIR aloha for aloha dalire. Over the past two days hundreds have come to say not only to say good bye.. But mahalo as well for the many moments and dances she shared. 1:35-1:46 cazimero I ALSO THINK THIS IS A GREAT WAY TO CELEBRATE NOT ONLY HER LIFE, BUT HER MOMS LIFT AND WHAT THEY HAVE DONE AS FAR AS THE LEGACY OF HULA IS CONCERNED. Inside the chapel a Celebration of Life... 32:39-32:50 KAUI ONE OF THE GREATEST LESSONS THAT MOM TAUGHT ME AS WELL SHE TAUGHT ALL OF US WAS TO REMEMBER OUR PS AND QS. I STILL TO THIS DAY DON'T KNOW WHAT PS AND QS STAND FOR! 35:15-35;25 KAPUA AS you NURTURED ME AND RAISED ME TO BE THE WOMAN I AM TODAY I WATCHED AND ADMIRED HOW YOU MADE EVERYONE WHO CAME INOT YOUR LIFE A PART OF YOUR WORLD. 45:41 But most of all it was the HULA... And her hula legacy.. As her daughters led dozens in dance. sot full song The room filled with of Hundreds OF strands of pikake lei..... 41:30-41;43 ITS THE LEI THAT I CHERISH VERY CLOSE TO MY HEART AND I CHERISH THAT LEI WITH MY LOVE FOREVER AND EVER Frank Kawaikapuokala ni Hewitt shared the song he wrote that compared Dalire---his cousin--- to the pikake lei she loved so much--- 4741- 46;03 sound full. Ends with daughter hitting drum. Dissolve to her picture This Saturday night KITV will air the special "The light in the lady's eyes" ...... A look at the hula legacy of Aloha Dalire and her daughters. That's Saturday night at 6:00. A war hero, a senator, and now a man who's being
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text: Profile Topics Started Replies Created Favorites Forum Replies Created Viewing 1 post (of 1 total) Author Posts January 17, 2013 at 4:07 pm in reply to: Avia Slider Issues #33121 MikeChatfieldParticipant Sorry if this isn't in the right place but I don't seem to be able to find where to start a new topic OR find a topic which is answering my question and I don't have hours to search it out. I have purchased the Avia Slider and need to know these things: - How do I link the slides to other web-pages or remove the links? – How do I change the width of the slider? Any help, links to answers etc. would be great thanks. Author Posts Viewing 1 post (of 1 total)


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Play our fun game and find out if the one you like likes you back. Confide in us if you think you'd hit it off by clicking: Yes, No, or Maybe. We'll anonymously find out and let you know if the feeling is mutual. You have nothing to lose!
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Isn't that feeling of attraction incredible? Imagine for just a moment, relaxing into caring arms holding you, making you feel safe, appreciated, and intimate. Knowing it is totally right. I believe those who know me best would describe me as a kind, respectful, dependable, a great listener, witty, fun loving, thoughtful, caring, warm, compassionate, genuine, loyal, and intensely romantic. Did I forget to mention humble? Seriously, I love to laugh and have fun. I'm also adventurous and very spontaneous. I can be very affectionate, and I'm not afraid to show it. I am also a very passionate person. I am career-oriented professional. I love to try new things, but find that what counts the most, is not the activity I'm doing, but whom I'm doing it with! I am somewhat of a risk taker, and believe in creating my own destiny. I feel I am emotionally literate and available. I am not afraid of commitment, but I'm selective and I am looking for someone who is also selective, but ready for a truly incredible relationship in which both our lives would be greatly enhanced. If something I've said intrigued you a bit, than please drop me a quick note telling me a little about yourself. Please have a recent photo as I do if you want me to respond. Be honest in your profile and NO surprises as I think we all can understand why. :) I take pride in working out 4-5 times a week and eat healthy. If you have no interest in fitness or taking care of yourself we probably won't match. I'm still somewhat skeptical of this on-line dating thing, but optimistically hopeful at the same time. Again, thank you for taking the time to read my profile and I wish you happiness. Let's meet! :)
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The main "couple."
So Uraboku has ended without resolving much of anything. The Average Anime Viewer might see this as an insult or a cop out, depending on his optimism (because the average is always male, don't you know). But are any of us really, truly surprised? This show was made to appeal to a specific (oh so specific) demographic–and, hey, if it should somehow also appeal to others, well, more money for them. Uraboku knows above all else its audience, and so the finale could not have turned out any differently.
I remember a momentary confusion as I witnessed the transition from climactic conflict to post-battle recovery. But then, as it went on, it all made perfect sense. This is not a show which ever concerned itself with its plot; the seriousness of its presentation was merely eye candy, a sparkly pretty thing to keep the viewer's interest as it built up to the meat of the show.
The meat being, of course, the characters. And by characters I mean bishounen (what females we see hardly count as characters, as they lack penises). A quick look at the primary cast sees all the major fetishes and cliches provided for: you've got your girly audience stand in, his protective/possessive "boyfriend," the big eater, the extant yet hardly so female, the stupid jerk with a heart of gold, the cold distant snarker with a Dark and Troubled Past, the perverted older man, the doctor, and the "older brother." Everything you could possibly need to attract a sizable female fanbase.
The aforementioned jerk and snarker, as viewed by fandom.
It occurs to me I have forgotten to spell out precisely what Uraboku's target audience is. Forgive me the obviousness, but this is rather important: the show targets females–specifically those inclined to fetishize homosexuality, but there (likely) is some overlap with the wider female demographic (that is to say, normal human beings). There, now I can move on to the (more) important stuff.
I said above (in slightly different words) that the audience dictated Uraboku's finale be as it is, so let me explain myself. You see, the upper echelons of the entertainment industry, wherever in the world you might find them, know how women think, what they want. And they have it on good authority (read: have made shittons of cash) that women don't care a lick about action or plot or whatnot; they would much rather watch a half hour of uninterrupted homoerotic subtext. Ergo, Uraboku's finale, simple as that.
Now I've (mostly) gotten the sarcasm out of the way, let's try and be a tad more serious.
Half as serious as this guy. At least.
Around episode fourteen, I noticed something that had been bothering me about the show: The writers spent most of the episode moving Yuki between different sets of characters, as if he were on a conveyor belt of subtext. This format continues through the rest of the series, at least for the slower episodes. There's only the barest of excuses for moving around as they do, which is where the plot comes in, but that's not the point. The point is to have Yuki speak with character X, or with Y and Z, or with whomever. This gives the fangirls plenty to squee over as they rush off after the credits to write yaoi or whatever. Because that's what girls do.
Granted, the show does mature about this somewhat by the last episode, where we've got enough characters that we move beyond just Yuki and mix in some new guys. Obviously this makes everything completely different from before, as now the show wants to tease at new pairings. But by the end everything is still as it should be. By which I mean that little has changed except maybe Yuki has a new power (the ability to magically end battles mid-climax, apparently) and we've all learned a lesson or something. (The sarcasm refuses to die, it seems.)
I suppose the plot does also serve to make various characters angst and provide fuel for Mr I-Will-Never-Betray-You to say his line, but that I think is just a subset of the above, grease to get the conveyor belt running. Because it's that same conveyor belt that's really running the show.
This is actually more subtle than the show, which hovered about half a layer of clothing short of full on buttsecks.
It's actually the most amusing part of the show, from a certain perspective, to watch the ever escalating subtext. How will they top themselves this week, I wondered as I clicked on each episode. Nor did they ever fail to deliver. (I refer you to this tweet from when I was watching the last episode.)
And that's all that matters, isn't it–the amusement? What does it matter that the show eschewed any sort of resolution in favor of a vague (and brief) analysis of what happened and Hotsuma spilling ice cream on Shusei's bed? The show is targeted at girls, and we know they don't care for plot, so can we really fault them for skipping over it? From the beginning Uraboku was only ever about one thing, the one thing it knew best, and it made no effort at hiding that.
I can only wonder why, for a show so stuffed with homoeroticism, there were no overt displays of homosexuality. I understand the source is only shounen ai, but does that really restrict the adaptation from showing even a single kiss? Or even just spoken confirmation of some sort? I predicted earlier that Yuki's reincarnation as a male might play some greater role (and thus explore gender identity in an interesting fashion), but they skipped over that with only a brief mention near the end. So, really, did Uraboku do anything?
I can't say that it did.
Unless you count having more metaphorical gay sex than Freud and Jung on an acid trip.


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Milwaukee Journal Sentinel: Women descended from Civil War Union soldiers form area chapter
By Meg Jones of the Journal Sentinel Aaron Stockholm was lucky. Thousands of men in blue and gray were wounded and killed on the hellish battlefields in the small Pennsylvania town of Gettysburg, but Aaron Stockholm was not one of them. Somehow the … Continue reading
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The Slip :: 06.26.09 :: Bowery Ballroom :: New York, NY
Though they haven't performed under The Slip moniker since 2007 (save for two shows at High Sierra and a one-off around NYE in Boston), the boys have been keeping plenty busy. They expanded to a quartet (with singer-songwriter Nathan Moore) to tour and record as Surprise Me Mr. Davis, and served as the backing band for the young singer Sonya Kitchell. But only as The Slip do they truly bring out the musical magic that has kept fans coming back for more than a decade (the fire started burning with 1997's From The Gecko).
Sporting a quickly discarded white glove, Brad Barr took the stage with his bandmates just after 10:30 p.m. Bassist Marc Friedman started the night on guitar and can apparently add guitarist to his list of credits in the band. For several of Eisenhower's more complex tunes bass duties went to a pre-programmed sampler while Friedman proved he can rock as hard as Barr on a six-string. Drummer Andrew Barr's collection of unusual percussion instruments wasn't hauled on stage in vain, so armed with shakers, bells, a whirling plastic tube and a well-rosined bow he brought out funky rhythms and ethereal tones from just about everything he had within arm's reach.
The funky start-stop instrumental "Get Me With Fuji" was next with Brad taking his first solo of the night, a Scofield sounding whirlwind of dirty arpeggios and crunchy chords; Brad's style has continued to develop and improve. After a slower acoustic tune and comments on the lightning storm over the Brooklyn Bridge earlier in the night, the audience got reassurance that the band is back and "have been writing a lot," with the debut of a new tune. The group's songwriting has evolved impressively over the years and unfamiliar ears may have a hard time believing the jazz material of their early days came from the same band that wrote this Coldplay meets Ringo rock tune full of hard hits and wailing blues guitar.
Delving back into Eisenhower, the slower "Suffocation Keep" came next, followed by crowd favorite "Airplane/Primitive." This one shot the energy level right to the top and created the closest thing to a mosh-pit as you will ever find at a Slip show. Brad brought out a small cassette player and fed it right into his guitar pickups for "First Panda in Space," while his brother whirled a flexible plastic tube around, generating some cool howling feedback.
As a lead singer Brad Barr is often flat on stage but he found his sweet spot during the awesome "Paper Birds." His affinity for Dylan comes out in "Birds," where he sings, "I know my song well before it leaves my lip." Unfortunately, as well as he may know them, his voice starts to give out as soon as he warms up all the way. Still only about 24 hours from confirmation of the early death of the King of Pop at the time, the band offered a touching tribute with an instrumental version of Jackson's "Man In the Mirror," with the audience adding enthusiastic vocals.
As they left the stage the audience proved they were a musical bunch as well. The applause filtered down to a nicely syncopated clapping-jam to get the band back on stage. Saying it was one of the first songs they wrote as a band, The Slip came back and delivered the first of two encore gems: "The Weight of Solomon." Originally an up-beat jazz ballad, the song has been worked into more of an alt rock tune with lots of down-strummed guitars replacing the warm jazz keyboard part. After a night of going hard Brad's voice was truly shot and rather than stretch for notes he couldn't hit he just let the audience take over for some of the lyrics. Finally, the most requested song of the night, "Children of December," ended the show and saw the band truly give it everything they had. Brad gave himself entirely to the crowd, falling back into their waiting hands he was held aloft, still playing his guitar as he was passed around the crowd on his back.
There was nothing but trust and love between the band and their fans this night and one hopes that after their brief return to the stage The Slip will continue their ascent as one of the most creative and talented bands around. Seeing how far they have come only makes one wonder just how much further they will go.
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WASHINGTON -- The last thing House progressives want is for the Supreme Court to strike down President Barack Obama's health care law. But if the high court rules Thursday that some or all of the law is unconstitutional, progressives are ready to renew their push for the model of health care they wanted all along: the single-payer option.
"It's easy to see it's a good idea," Rep. Keith Ellison (D-Minn.), co-chairman of the Congressional Progressive Caucus, told The Huffington Post. "It's the cheapest way to cover everybody."
Ellison said all 75 members of the caucus have already signed onto a bill by Rep. John Conyers (D-Mich.) to create a single-payer, publicly financed, privately delivered universal health care program. The proposal would essentially build on and expand Medicare, under which all Americans would be guaranteed access to health care regardless of an ability to pay or pre-existing health conditions.
House progressives pushed hard for a single-payer option, such as the "Medicare for all" approach, during the health care reform debate in 2009. But House Democratic leaders couldn't come up with the votes to pass the proposal, and progressives ultimately caved on the idea in order to pass the president's plan, on the reasoning that some reform was better than none at all.
Asked why progressives think a single-payer option could advance this time around, Ellison said if the Supreme Court strikes down some or all of the existing health care law, it shows that the individual mandate at the heart of the law -- a concept originally backed by conservatives -- was a failed approach.
"We've tried it the right-wing way. Let's try it the right way," he said.
Rep. Jerrold Nadler (D-N.Y.) said he led the charge for reviving the single-payer health plan during a recent Progressive Caucus meeting.
"We agreed we're going to come out in favor of Medicare for all, in both instances," he said, referring to the Supreme Court possibly striking either some or all of the health care law. "One disadvantage of saying, 'Let's go for single payer,' is that by and large the American people have no idea what that means. But the advantage of saying 'Medicare for all,' the American people do know what that means. And it's a very popular proposal."
Nadler said he didn't know how Democratic leadership would feel about revisiting the idea. He said that will depend largely on how the White House responds to the Supreme Court's ruling, whatever it is.
A House Democratic leadership aide suggested party leaders aren't about to embrace a single-payer option anytime soon.
"I think we have to recognize the situation we're in with House Republicans, where we can't even get bipartisan legislation finished," said the aide. "We can talk about specific proposals and have discussions and have that as something to focus on or talk to constituents about as they run for reelection. It's just not going anywhere in this Congress."
UPDATE: 1:45 p.m. -- White House Press Secretary Jay Carney later brushed off a question about whether Obama would support a single-payer option in the event his law gets struck down.
"The president favors the Affordable Care Act," Carney said at his daily briefing. "The president, as you are, is awaiting the decision. We will assess it as it comes."
UPDATE: 2:55 p.m. -- Progressives acknowledge there are obstacles but say it would still be best to embrace a "Medicare for all" approach.
"There's no chance that [House Speaker] John Boehner is going to bring that up for a vote," Rep. Peter Welch (D-Vt.) said on a conference call. "We have to have an alternative policy that we're promoting that shows where we want to go," he said, adding that he sees it as a long-term fight that could have short-term benefits in the fall.
"We'll have to start agitating and the two focuses for me will be what we're for -- Medicare for all -- and no. 2, indicting a Boehner-led House that has no Plan A, even to maintain the popular insurance reforms that mean a lot to the American people," he said. "It will be an opportunity for the American people to weigh in, in the election."
CORRECTION: A previous version of this article misidentified Keith Ellison as a representative from Missouri. He is from Minnesota.
Below, a slideshow of previous health care reform efforts:
Former President Theodore Roosevelt champions national health insurance as he unsuccessfully tries to ride his progressive Bull Moose Party back to the White House. (Photo by Topical Press Agency/Getty Images)
President Franklin D. Roosevelt favors creating national health insurance amid the Great Depression but decides to push for Social Security first. (Photo by Keystone/Getty Images)
Roosevelt establishes wage and price controls during World War II. Businesses can't attract workers with higher pay so they compete through added benefits, including health insurance, which grows into a workplace perk. (Photo by Hulton Archive/Getty Images)
President Harry Truman calls on Congress to create a national insurance program for those who pay voluntary fees. The American Medical Association denounces the idea as "socialized medicine" and it goes nowhere. (Photo by Keystone/Getty Images)
John F. Kennedy makes health care a major campaign issue but as president can't get a plan for the elderly through Congress. (Photo by Keystone/Getty Images)
President Lyndon B. Johnson's legendary arm-twisting and a Congress dominated by his fellow Democrats lead to creation of two landmark government health programs: Medicare for the elderly and Medicaid for the poor. (AFP/AFP/Getty Images)
President Richard Nixon wants to require employers to cover their workers and create federal subsidies to help everyone else buy private insurance. The Watergate scandal intervenes. (Photo by Keystone/Getty Images)
President Jimmy Carter pushes a mandatory national health plan, but economic recession helps push it aside. (Photo by Central Press/Getty Images)
President Ronald Reagan signs COBRA, a requirement that employers let former workers stay on the company health plan for 18 months after leaving a job, with workers bearing the cost. (MIKE SARGENT/AFP/Getty Images)
Congress expands Medicare by adding a prescription drug benefit and catastrophic care coverage. It doesn't last long. Barraged by protests from older Americans upset about paying a tax to finance the additional coverage, Congress repeals the law the next year. (TIM SLOAN/AFP/Getty Images)
President Bill Clinton puts first lady Hillary Rodham Clinton in charge of developing what becomes a 1,300-page plan for universal coverage. It requires businesses to cover their workers and mandates that everyone have health insurance. The plan meets Republican opposition, divides Democrats and comes under a firestorm of lobbying from businesses and the health care industry. It dies in the Senate. (PAUL J. RICHARDS/AFP/Getty Images)
Clinton signs bipartisan legislation creating a state-federal program to provide coverage for millions of children in families of modest means whose incomes are too high to qualify for Medicaid. (JAMAL A. WILSON/AFP/Getty Images)
President George W. Bush persuades Congress to add prescription drug coverage to Medicare in a major expansion of the program for older people. (STEPHEN JAFFE/AFP/Getty Images)
Hillary Rodham Clinton promotes a sweeping health care plan in her bid for the Democratic presidential nomination. She loses to Obama, who has a less comprehensive plan. (PAUL RICHARDS/AFP/Getty Images)
President Barack Obama and the Democratic-controlled Congress spend an intense year ironing out legislation to require most companies to cover their workers; mandate that everyone have coverage or pay a fine; require insurance companies to accept all comers, regardless of any pre-existing conditions; and assist people who can't afford insurance. (Alex Wong/Getty Images)
With no Republican support, Congress passes the measure, designed to extend health care coverage to more than 30 million uninsured people. Republican opponents scorned the law as "Obamacare." (Mark Wilson/Getty Images)
On a campaign tour in the Midwest, Obama himself embraces the term "Obamacare" and says the law shows "I do care." (BRENDAN SMIALOWSKI/AFP/Getty Images)


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Computational Toxicology Research Program
SDF Download Page
KIERBL: EPA Estrogen Receptor Ki Binding Study (Laws et al.)
Database File
** Launch Version 1a, 17 February 2009
Quick & Easy File Downloads: FTP Download Instructions
Source Contacts
Main Citations
Guidance for Use
SDF Fields
SDF Download Table
Acknowledgements, DSSTox Citation & Disclaimer
New Users: For general information, see DSSTox Project Goals and About DSSTox. For additional information on DSSTox SDF (Structure Data Format) files and their use in Chemical Relational Databases, see More on SDF and More on CRDs.
Description: This study was conducted by EPA researchers to evaluate the validity of the rat uterine cytosolic (RUC) estrogen receptor (ER) competitive binding assay for use in the Endocrine Disruption Screening Program (EDSP). The assay measures the ability of radiolabeled 17-beta-estradiol (3H-E2) to bind with RUC ER in the presence of increasing concentrations of a test chemical. The goal is to employ this in vitro assay as a 1st tier sceening tool for assessing the potential of structurally diverse environmental chemicals to bind to the ER, as well as to support research efforts to develop computational models to predict ER binding. A distinguising feature of the present study from other ER competitive binding studies (see, e.g., NCTRER) was the use of secondary experimental analysis to confirm that measured IC50 values corresponded to true positive results. This was accomplished by secondary analysis using Lineweaver-Burk plots and slope replots to determine true competitive inhibition and an experimental Ki value (inhibitor binding constant) -- see also: Relating IC50 values to Ki values . The study concluded that a number of experimental conditions can confound interpretation of IC50 values obtained from the RUC ER-binding assay data and lead to false positive results. In particular, some chemical treatments likely alter the stability of the assay by changing the buffer pH, denaturing ER, or disrupting the ER binding kinetics. In addition, in some cases, neither an IC50 or Ki value could be determined due to solubility constraints (i.e., sufficient concentration of the chemical to produce greater than 40% inhibition could not be experimentally achieved).
The chemicals used in this study were selected as part of a validation test for two Quantitative Structure-Activity Relationship (QSAR) models designed to predict ER binding [Fed. Reg. 67(250), 79618, Dec. 30, 2002]. Several hundred chemicals were initially screened, including approximately 100 chemicals selected from among the High Production Volume (HPV) chemicals included in EPA's Toxic Substances Control Act (TSCA) inventory that were predicted to be positive for ER binding, with the rest selected at random from the TSCA inventory. All chemicals were initially tested in ER competitive binding assays by Battelle Pacific Northwest Laboratories, Richland, Washington [EPA Contract Number 68-W-99-033, Task 6]. Approximately 50 chemicals produced binding curves that: (1) strongly implied competitive inhibition of ER binding, or (2) produced partial curves or irregular (non-sigmoid) binding curves. These chemicals were further evaluated in an ER competitive binding assay with secondary analysis to confirm true competitive inhibition and to determine an experimental Ki [U.S. EPA Contract 3D-5967-NTEX]. The results of RUC ER screening for these 50 structurally diverse chemicals, for which secondary confirmatory analyses were performed, were published in the Main Citation (Laws et al., 2006). The remaining 228 chemicals were designated as non-binders (i.e., inactives) since these chemicals at concentrations up to 100 micromolar failed to inhibit the maximum binding of radiolabeled estradiol more than 20%.
The DSSTox KIERBL data files include all published IC50 and Ki experimental results for the 50 chemicals included in the Main Citation (Laws et al., 2006) (denoted Group 1), as well as previously unpublished results for an additional 228 structurally diverse TSCA chemicals for which no ER binding was observed (denoted Group 2). IC50 values were determined for 32 compounds in Group 1. For 19 of these having nearly complete or partial competitive binding curves, i.e. displacing >75% and >50% 3H-E2, respectively, secondary analysis was able to determine Ki values for a total of 17 compounds (designated "active"), whereas two of the 19 compounds were determined by secondary analysis to be non-binders. Of the remaining 31 Group 1 chemicals, no Ki could be determined for 8 compounds due to solubility limitations (designated "inconclusive"), and 23 chemicals were confirmed as non-binders (designated "inactive"). Hence, of the original 32 compounds in Group 1 with IC50 values indicating some level of competitive ER binding, Ki values could be determined for only 17 of these (53%), whereas 7 compounds (22%) were confirmed to be non-binders, and 8 (25%) produced inconclusive results due to solubility constraints. These results indicate that the incidence of true ER binders detected by the RUC ER assay was substantially less than implied by IC50 values alone. The 228 compounds in Group 2 were tested in the RUC ER competitive binding assay and designated as non-binders (i.e., inactives) since these chemicals at concentrations up to 100 micromolar failed to inhibit the maximum binding of radiolabeled estradiol more than 20%.
Source Contacts: Susan C. Laws, U.S. EPA, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, Endocrinology Branch, MD-72, Alexander Drive, Research Triangle Park, NC 27711; Email: firstname.lastname@example.com;
Jim Kariya, EPA, OPPTS, Office of Science Coordination and Policy, EACPD, EPA East Building, 1200 Pennsylvania Ave, N.W., Mail Code 7203M, Washington, DC. 20460; Email: firstname.lastname@example.com
Main Citations: Publications reporting use of DSSTox SDF file for KIERBL are asked to list the full DSSTox file name(s), including date stamp, and to cite as primary references the following:
Laws SC, Yavanhxay S, Copper RL, Eldridge JC. 2006. Nature of the binding interaction for 50 structurally diverse chemicals with rat estrogen receptors. Toxicological Sciences. 94(1), 46-56; doi:10.1093/toxsci/kfl092.
Download PDF for personal use, published by Oxford University Press 2006
U.S.EPA. 2002. Endocrine Disruptor Screening Program: Chemical Selection Approach for Initial Round of Screening. Federal Register, 67(250): 79618.
USEPA. 2002. Development of estrogen binding data for approximately 300 chemicals: final data package submittal. EPA Contract No. 68-W-99-033, Work Assignment 3-04.
Guidance for Use: A user of the DSSTox KIERBL SDF files is encouraged to consult the Main Citation (Laws et al., 2006) for further information and experimental details pertaining to this study (for further information on assay protocol, see also ICCVAM/NTP document). Although IC50 values are provided in the DSSTox KIERBL data file for completeness sake (IC50_microM), their use as a quantitative activity endpoint for QSAR modeling of ER binding is not recommended based on the overall conclusions of this study. Rather, reported Ki values are believed to provide the more definitive measure of true ER binding and the more accurate quantitative measure of binding inhibition. Hence, DSTox PubChem activity assignments, ActivityOutcome_KIERBL and ActivityScore_KIERBL, are based on Ki values of confirmed binders (Ki_microM_mean), with 17compounds classified as "active", 8 compounds labeled "inconclusive" due to solubility constraints preventing determination of Ki values, and the remaining 253 compounds classified as non-binders and labeled as "inactive". ActivityScore_KIERBL values project log10(Ki_microM_mean) values onto a 10-100 activity range, with the strongest binder (E2) assigned a score of "100", the weakest confirmed binder assigned a score of "10", inconclusives assigned a score of "5", and inactives assigned a score of "0".
The KIERBL Field Definition File (see Download Table below) contains essential documentation and should be downloaded with, and accompany any use of the DSSTox KIERBL SDF file. The KIERBL Log File provides database summary information (field, chemical counts, etc.) and a description of procedures and quality assurance checks used in SDF file creation. In addition, the Log File documents modifications incorporated into version/revision updates of the DSSTox KIERBL SDF file. For additional information on DSSTox SDF files and their use in Chemical Relational Databases, see More on SDF and More on CRDs. To report errors in any KIERBL documentation or SDF data file, click on File Error Report here or below.
DSSTox Standard Chemical Fields (20)
DSSTox Standard Toxicity Fields (4) * Assay_Target new field added Feb2009
Source_ChemicalName new field added Jan2009
* Note: For detailed information on SDF content, see KIERBL_FieldDefinitionFile in Download Table below.
File Download Notes: The following files are offered in the DownLoad table below:
Log File (PDF) provides SDF data file version history and summary information (field, chemical counts, etc.), and a description of procedures and quality assurance checks used in SDF file creation;
Field Definition File (PDF or MS Word doc file) provides field definitions and essential documentation, and should be downloaded with and accompany any use of the DSSTox SDF file;
Structure Data File (SDF) is the main DSSTox product, providing the complete inventory of chemical structures, DSSTox Standard Chemical Fields, and all Source-specific data fields [Note: the structure field is blank for all records containing mixtures or undefined substances];
Data Table MS Excel (MS Office 2003) file contains the full SDF data contents in spreadsheet table form, minus the chemical structure field [file created with CambridgeSoft ChemDraw Ultra 2004 plug-in to MS Excel 2003];
Structures Table (PDF) file contains a tiled format graphical view of all chemical structures contained in the SDF file, annotated with TestSubstance_CASRN and truncated TestSubstance_ChemicalName field entries for the tested form of the chemical [file created with ACD ChemFolder, ver. 11.02, ACD Labs].
|You will need Adobe Acrobat Reader, available as a free download, to view the Adobe PDF files on this page. See EPA's PDF page to learn more about PDF, and for a link to the free Acrobat Reader.
These files constitute the main DSSTox products. DSSTox Documentation Files use standard templates, and DSSTox Structure Data Files and DSSTox File Names adhere to strict formatting standards and conventions. For additional information, see More on DSSTox Standard Chemical Fields, Known Problems & Fixes, Chemical Information Quality Review Procedures, and How to Use DSSTox Files.
Quick & Easy File Downloads: FTP Download
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Acknowledgements: The DSSTTox SDF file for KIERBL includes the 50 chemicals in the original Laws et al. publication and an additional 228 chemicals tested by Battelle Pacific Northwest Laboratories, Richland, WA (USEPA Contract 68-W-99-033, Task 6). The list of additional chemicals was kindly provided by Jim Kariya, EPA. The file was converted to DSSTOX format by Maritja Wolf (Lockheed Martin, Contractor for EPA) and Ann Richard (EPA). We additionally thank Michelle Hotchkiss, Janet Ferrell (EPA) and Rocky Goldsmith (EPA) for assistance with the review of the final files and documentation.
DSSTox Citation: S. Laws, J. Kariya, M. Wolf, and A.M. Richard (2009) DSSTox EPA Estrogen Receptor Ki Binding Study (Laws et al.) Database - (KIERBL): SDF file and documentation, Launch version: KIERBL_v1a_278_17Feb2009, www.epa.gov/ncct/dsstox/sdf_kierbl.html
Disclaimer: Every effort is made to ensure that DSSTox SDF files and associated documentation are error-free, but neither the DSSTox Source collaborators nor the EPA DSSTox project team make guarantees of accuracy, nor are any of these persons to be held liable for any subsequent use of these public data. The contents of this webpage and supporting documents have been subjected to review by the National Center for Computational Toxicology and approved for publication. Approval does not signify that the contents reflect the views of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. See additional disclaimers.


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THE CONSTITUENCIES; In Coup, Ferrer Is Asked to Speak
Published: July 28, 2004
BOSTON, July 27— In an 11th-hour decision by the campaign of Senator John Kerry, Fernando Ferrer, the former Bronx borough president, was asked to address the Democratic National Convention on Wednesday evening.
His selection is a political boost as Mr. Ferrer prepares to challenge Michael R. Bloomberg for mayor next year, even though his speech is scheduled for early evening, long before prime time.
Mr. Ferrer said he would speak about ''issues that are at the heart of the Democratic Party: affordable housing, health care, for example.''
Mr. Ferrer said the invitation had been offered Tuesday afternoon by Kerry campaign officials. Asked whether it would have a positive impact on his mayoral aspirations, he said: ''I'm not thinking about any of that right now. The important thing right now is to get John Kerry elected.''
Other potential contenders for mayor, including the City Council speaker, Gifford Miller, and the city comptroller, William C. Thompson Jr., are here for the convention, but were not invited to speak.
Mr. Thompson said he did not think the invitation would make a difference in the campaign. ''I think that the convention is the convention, and what happens in New York happens in New York,'' he said.


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Most Popular in:
The Fragrance Horizon: 2009 and Beyond
By: Jeb Gleason-Allured, Editor, Perfumer & Flavorist magazine
Posted: January 23, 2009, from the February 2009 issue of GCI Magazine.
page 2 of 5
"Our industry has been obsessed in recent years with the need to be core-listed by major customers," Wright continues. "Mergers and acquisitions have been seen as a good way to ensure inclusion on core lists. Core listing makes good sense for customers. Nobody can deal effectively with unfocussed submissions from dozens of suppliers. However, the opposite extreme is equally unattractive. All F&F suppliers have highly characteristic competencies and tend to formulate within a familiar comfort zone. No customer wants to be limited to one or two 'take it or leave it' choices. [It is] best to have a core list of three or four suppliers with an additional couple of challengers. This provides plenty of incentive for the suppliers and plenty of choice for the product developers. If our industry consolidates much further it will be impossible to have this level of relevant choice."
Raw Materials
"During 2008, the flavor and fragrance industry saw a huge price rise in many of the commodities that are basic to our business," says Hughes. "This, coupled with historic levels of energy costs, created margin erosion that was difficult to gain back through sales price increases or even a change to alternate sources. Finally, [there are] issues related to off-shore supply of certain materials and some key customer policies against the use of them. In 2009, the challenge to assure a stable sustainable supply of quality raw materials at a reasonable price will remain a priority."
A group report from drom's international marketing staff and perfumers Pierre Gueros, Delphine Jelk and Kevin Verspoor adds, "A negative consequence of the [current economic] crisis will be that, on the raw material side, there will be less development of new chemicals because of the price of testing."
Wright adds, "Most F&F companies assume that raw material R&D in both flavors and fragrances will continue for many years along relatively conventional lines—ever more detailed analysis of nature and ingenuity in organic chemistry. These approaches still appear to be delivering the goods; GRAS 23 alone added over 170 new flavor ingredients! Closer examination tells a different story. Many of the additions are not exactly new, and many more simply represent small variations in structure. I suspect that each truly novel ingredient will become more and more difficult to find and, sadly, less and less game changing in its impact."
On the other hand, Hughes presents some silver lining. "The major consumer CPG companies continue to search for ways to differentiate their brands from their competitors and private label products," he says. "Flavor suppliers, for example, can assist with this effort by combining unique technologies such as taste modifying materials with proprietary encapsulation techniques to 'insulate' the customer brand from competition."


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About Papa Roach
Starting out as a punk- and rap-influenced band, the Northern California group Papa Roach eventually grew into a straight-ahead hard rock ensemble with strong heavy metal leanings. Consisting of Coby Dick, Jerry Horton, Dave Buckner, and Tobin Esperance, Papa Roach formed in 1993 and began releasing EPs soon after, including 1994's Potatoes for Christmas and 1995's Caca Bonita. By 1996, the group had replaced original bassist Will James with Esperance and hired a new manager; the following year, Papa Roach released their first full-length album, Old Friends from Young Years, which became a surprise hit on local radio.
The band's regional success led to more prominent gigs, including dates with Suicidal Tendencies, Sevendust, and Powerman 5000, and a deal with Dreamworks Records, which released Papa Roach's second album, Infest, in early 2000. The album went triple platinum thanks to the success of "Last Resort," an intensely popular single that helped make Papa Roach one of the most beloved hard rock acts of the new millennium. Two years later, frontman Coby Dick opted to go by his given name of Jacoby Shaddix, and a new album, lovehatetragedy, was released that June. Stylistically, the band had begun to grow beyond its rap-rock roots and the new tracks showcased a slightly more mature, melodic, and straightforward hard rock sound. That same summer, however, the band joined a number of rap acts -- including Ludacris and Xzibit -- on Eminem's Anger Management Tour.
In 2004, Papa Roach released their fourth studio effort, Getting Away with Murder. Buoyed by the success of the single "Scars," Getting Away with Murder sold well and eventually went platinum. Two years later, Papa Roach began work on their next studio album at the infamous and historical Paramour mansion in Hollywood, once the home of silent movie star Antonio Moreno. Released in fall 2006, The Paramour Sessions featured a heavy L.A. rock aesthetic and generated two Top Ten rock singles, although its sales stalled around 400,000 copies. Drummer Dave Buckner exited the lineup one year later; after filling the empty seat with Unwritten Law's Tony Palermo, Papa Roach hit the road to support The Paramour Sessions with tour dates alongside Seether and Staind. They remained on the road after joining Mötley Crüe's Crüe Fest in 2008, but the band also found time to return to the Paramour mansion, where they launched songwriting sessions for another album.
Released in early 2009, Metamorphosis found Papa Roach reprising their interpretation of metallic hard rock and reuniting with Infest producer Jay Baumgardner. Papa Roach parted ways with Interscope in 2010 and signed a deal with the independent Eleven Seven label. The career-spanning collection The Best of Papa Roach: To Be Loved also appeared in 2010. The band's first album for Eleven Seven, Time for Annihilation, combined new cuts and live re-recordings of their hits and appeared in August of 2010. In 2012, Papa Roach delivered their seventh studio album, The Connection. Featuring production from Sixx: A.M. frontman James Michael as well as Goldfinger's John Feldmann, the album showcased a mix of the styles and sounds the band had touched on over the years, from rap to more straight-ahead hard rock, as well as incorporating a distinct electronic influence. The electronic element became even more pronounced on their next album, 2015's F.E.A.R. ("Face Everything And Rise"), which boasted an even more radio-friendly, industrial-tinged pop-metal sound. ~ Heather Phares, Rovi
Tour Dates
Oct 06 TuesdayLowell, MA, US Tsongas Center, UMass Lowell
Oct 08 ThursdayUncasville, CT, US Mohegan Sun Arena
Oct 09 FridayGlens Falls, NY, US Glens Falls Civic Center
Oct 10 SaturdayChester, PA, US Ppl Park
Oct 17 SaturdayThe Woodlands, TX, US Cynthia Woods Mitchell Pavilion
Nov 04 WednesdayStockholm, Sweden Hovet
Nov 04 WednesdayStockholm, Sweden Hovet
Nov 05 ThursdayOslo, Norway Sentrum Scene
Nov 06 FridayCopenhagen, Denmark Tap1
Nov 08 SundayHannover, Germany Swiss Life Hall
Nov 09 MondayLeipzig, Germany Arena Leipzig
Nov 11 WednesdayStuttgart, Germany Porsche-arena
Nov 13 FridayFrankfurt, Germany Jahrhunderthalle Frankfurt
Nov 15 SundayLille, France L'Aéronef
Nov 16 MondayParis, France L'Olympia
Nov 17 TuesdayAmsterdam, Netherlands Heineken Music Hall
Nov 19 ThursdayMunich, Germany Zenith, Die Kulturhalle
Nov 20 FridayPrague, Czech Republic Malá Sportovní Hala
Nov 21 SaturdayVienna, Austria Gasometer
Nov 22 SundayMilan, Italy Alcatraz
Nov 24 TuesdayBerlin, Germany Columbiahalle
Nov 25 WednesdayDüsseldorf, Germany Mitsubishi Electric Halle
Nov 26 ThursdayBrussels, Belgium Forest National
Nov 28 SaturdayLondon, UK Wembley Arena
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