text:
Rebecca Minkoff
Cooper Convertible Clutch
$189 Gilt
- Color:
- burgundy
Qty: 1
- 1
- 2
Please select an available size.
Please select a size.
Description: Large clutch
- Supple leather with buckle details and back slip pocket
- Optional leather and chain-link shoulder strap
- Flap opening with hidden magnetic closure
- Signature printed interior lining with a three slip pockets and a zip pocket
Measurements: Body length 12", height 7½", width 2", strap drop 13"
Material: Leather
Brand: Rebecca Minkoff
Origin: Imported


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Initially the new video channel will be available only in Japan. It'll offer family-focused content created specifically for the service, rather than existing shows or movies, and is set to debut next year with both free (funded by advertising) and paid videos.
The new service is being released as a collaborative effort between Nintendo and advertising agency Dentsu, which is looking after content and advertising negotiations. It�s unclear whether Nintendo plans to make the service available outside of Japan, though it is probably in their best interest to scale it out globally at some point.

subset: commoncrawl


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read/write to eprom/eeprom
read/write to eprom/eepromJune 8, 2008 - 01:21
In J2ME, how can i read/write from/to my eprom/eeprom cell phone area? (to keep data even the battery is empty)
Re: read/write to eprom/eepromJune 9, 2008 - 07:46
For JavaME MID Profile what you are looking for is the RMS (Record Management System).
This APIs are available in the javax.microedition.rms package.
There is also JSR75 PDA for Filesystem support which writes to a MMC/SD/MS card, and some have an internal memory area.


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Without Phil, Does Odom Still Make Sense?
But if Odom – born and raised in Queens and by all accounts fully fond of his native city – is willing to do what Baron Davis did and sign for the veteran's minimum, it will be another coup for a Knicks front office once again trying to thread the eye of the salary needle.
As for the actual roster, and Odom's potential role therein, the fit could not be more ideal. At 6 feet 10 inches, Odom is a veritable Swiss army knife of skills and strengths, all of which the Knicks could use. As the first forward off the bench, Odom would be the perfect plug-in for Amar'e Stoudemire, while giving the second unit – marshaled as it very well could be by the enigmatic Toney Douglas – a second reliable ball handler through which myriad halfcourt sets could be run. Couple that with serviceable rebounding and defense, and a long-renowned passing prowess, particularly out of the post, you have a player whose versatility and dynamism could do wonders for a top-heavy team pining for depth.
The Odom discussion started here, and I would have made him a shoe-in with Phil. I stand by my opinion that Phil and Odom would have made the Knicks a 50 plus win team. Does Odom make sense in Woodson's system? I don't know. His strengths are around the rim and in transition. He plays well off of stars and is incredibly selfless. I think those skills translate. As far as any realistic veteran free agent, to me, Odom is the by far the best available.
But does he choose NY over LA without Phil?


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Ankle - Foot
Ankle Bone Diagrams
Medial and Lateral Malleolus
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Side-view of ankle. Note the central location of the medial malleolar ligaments.
A frontal profile of the ankle bone, this diagram shows the location of both the lateral malleolus and medial malleolus, which intersect at the joint.
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A convenient carry bag for digital DJs and laptop performers based on the UDG CourierBag Deluxe.
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FORT PIERCE, Fla. - A Port Saint Lucie, Fla., resident, 23, was charged with transporting child pornography following a U.S. Immigration and Customs Enforcement (ICE) led investigation.
Jason David Bingham appeared in federal court April 24, for his initial appearance on charges of transporting child pornography and was detained without bond.
According to the criminal complaint, the investigation began on February 15, 2009, when officers from the German Federal Police (BKA) downloaded approximately 37 image files that included 24 images depicting minor children engaged in sexually explicit conduct. One of these images is of a child who appears to be well under the age of eight.
The BKA, with assistance of ICE Cyber Crimes Center (IC3), learned that Bingham's computer utilized an Internet Protocol address that was assigned to a residence located in Port St. Lucie, Fla.
On April 23, 2009, ICE special agents in Fort Pierce, with the assistance of detectives from the Port St. Lucie Police Department and Martin County Sheriff's Office, executed a federal search warrant at the defendant's home and seized computers, hard drives and media. Bingham admitted he downloaded and traded child pornography with others via the Internet and that he had images of children as young as infants engaged in sexually explicit conduct.
During a forensic preview by ICE's IC3 of a backup hard drive, which Bingham admitted to encrypting, agents observed Bingham's child pornography collection, consisting of numerous images of minors engaged in sexually explicit conduct. The total count of files on the drive was 577,943.
The ICE investigation and arrest was part of a U.S. Department of Homeland Security (DHS) ICE initiative known as Operation Predator. Operation Predator protects children from sexual predators, including those who travel across continents to have sex with minors, Internet child pornographers, criminal alien sex offenders and child traffickers. Since the initiative was launched in July 2003, there have been more than 11,900 individuals arrested nationwide.


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Readership: Scholars and advanced students of philosophy of logic, philosophy of mathematics, and history of analytic philosophy.
Richard G. Heck, Jr., Brown University
Richard G. Heck, Jr., is Romeo Elton Professor of Natural Theology at Brown University, where he has taught since 2005. He taught at Harvard University from 1991 through 2005 and was educated at the Massachusetts Institute of Technology, from which he received his PhD in 1991; at New College, Oxford (BPhil, 1987), where he was a Marshall Scholar; and at Duke University (BS, 1985). Professor Heck has worked on the philosophies of language, logic, mathematics, and mind, and is is one of the world's foremost experts on the philosophy of Gottlob Frege. He lives in
Canton, Massachusetts, with his wife, daughter, and five cats.
"Richard G. Heck's Reading Frege's Grundgesetze is a fantastic addition to the growing research that focuses primarily on Frege's Grundgesetze der Arithmetik. In fact, it is a must-read for any Frege scholar, or more broadly any philosopher interested in early analytic philosophy and logicians as well as mathematicians interested in the history of their field." - Philosophia Mathematica
"a masterpiece. Its detailed analysis and precision should serve as a model for Frege scholarship (and indeed any scholarship). The insights Heck gains from his analyses are groundbreaking. His exegesis is profound and will fuel discussions for
years to come. No Frege scholar, budding or established, and no philosopher of mathematics can afford to miss this book" - Marcus Rossberg, Notre Dame Philosophical Reviews
"Had it not already been clear to anyone following Richard Heck's work that he is one of the foremost Frege scholars of our time, it would have become hard to deny after the publication of his second book on Frege ... It investigates Frege's philosophy of logic and mathematics rigorously and meticulously ... [I] recommend Heck's book to anyone with interest in Frege's work, or indeed with an interest in the philosophy of mathematics" - Marcus Rossberg, Notre Dame Philosophical
Editorial Notes
1: Introduction
I: The Logic Behind Frege's Logicism
2: Frege and Semantics
3: Grundgesetze I §§29-32 (I)
4: Grundgesetze I §10
5: Grundgesetze I §§29-32 (II)
II: The Mathematics Behind Frege's Logicism
6: The Development of Arithmetic
7: Definition by Recursion
8: Frege on Finitude
9: The Finite and the Infinite
10: The Definition of Addition
11: Further unto the Infinite
12: Appendices


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Yeah, so i guess you did open up to him and let him into your private life, that had to be so scary for you. But through that godawful experience you gained strength. Unfortunately, when someone is depressed or dealing with a depressive episode, we fail to realize that we are effecting the lives of those around us. Depression is a funny thing, at least in my case, I struggle with self esteem and self worth. But when i look at the actions i have done, they are all about me and very selfish. I would be the first person to say that I am the least selfish person you'd ever meet...but am I? I tend to be "selfless" making sure that I make everyone around me happy and in doing so i neglect myself, because after all i feel worthless or undeserving. But i do those acts of kindness with the expectation of getting something in return, with out any verbal agreement, i just assume. And we all know what happens when we assume. And when i dont get anything back in return, it just validates how worthless i really am. Clearly this isnt a laughing matter, but looking back at everything it is completely illogical, for me to think this way. And i view my self as a fairly logical/analitical thinker, except when it comes to me LOL.
So if we apply that logic to your husband or even yourself with the cutting. He looks at the "stuff" and gets his mind off of what ever is bothering him and comes back to bed. To find his wife, whom he loves and has to deal with the guilt and shame of what he just did. Which probably depresses him more and the way he knows how to get out of that is to look at more "stuff". It's a horrible pattern and one that isnt easy to break, but you offering up an open ear and heart, might just do the trick. The best way to try and break him of that is finding other constructive things to do and use those to replace him looking at stuff. It doesnt need to be an intense project, but something that can distract his mind long enough that he can function.
Sorry I misunderstood about the food issue, i was just trying to figure out exactly how dependent he was of you. But giving what he had on his plate, i totally understand I cant remember if you said this or not, but is your husband an only child? His parents could have attachment issues because he left they are being mean just out of spite. This may sound harsh and is probably easier said than done, but HE really needs to confront his parents and give them boundaries. You can be there for support but he really needs to say this, he needs to prove to himself that he can stand up for himself. Could it possible strain/ruin their relationship, sure, but lets be honest, its not cloud 9 right now anyway. No one wants to lose a relationship with their parents, but when it toxic, he might not have a choice. And who knows with him actually speaking up for himself, they might realize the error of their ways.
Also, i saw this on another post and have often thought about this about myself. I dont know how old your husband is and its not my business. But he could have his testosterone levels checked. If he has low T that could explain a few of the symptoms, the depression and "ED". Just a thought.
Best of luck!
"I'm not a doctor, but i did stay at a holiday inn express last night."View Thread
First off im glad to read that you guys are commuicating better now and your being open. From my own experience, having someone who is compassionate can be huge. My ex- was not and that made me more shut down and defensive. I just felt that no matter what i said, she would judge me and assume the worst. Which is what she did all along and i gave her reasons to do so, but i digress. So continue to talk to him and try to be as understanding as possible. And if you want, if you have a secret or something that is very near to you, that you are comfortable about opening up about, that may help him, if nothing more to show him that we are human and we make mistakes and that it's ok.
Using the couples therapy to skirt the system is a good idea, but honestly, i dont think the couple is the problem. You seem like a very supportive spouse and he is a very lucky guy to have someone who is as open as you are. But as a couple going to therapy you can sort of keep him in check if they give him certain tasks to work on, etc.
As for your last question, we all have our quirks and kinks. And once you get on that topic and you combine it with the internet, look out. Pandora's box is wide open. And a lot of times, it's just nice to know that your not the only person with your particular "fetish". So you start to talk to people for a feeling of normalcy. Now stockings/hosiery is a pretty mild fetish and one that a spouse might not be intimidated by. I wont lie, i love the way a womans legs look in thigh highs/stockings. But for what ever reason, i have a hard time bringing that up to anyone i seriously date. I dont know why, it is not like its that kinky of a request. But it feeds into my need to be accepted, if i tell someone and they think im a freak, ill be crushed, so i keep it to myself. As for what i envision when im looking at porn, is just what i see. I have a creative mind, but not an imaginative one. Its difficult for me to picture something and see it vividly in my mind. Im creative in the sense that i can think outside the box to fix a problem. So what i see with my two eyes is what i see. I wish i could picture my partner(when i have one) but i rarely can. I know some guys who can just close their eyes and are able to get aroused, because of what they are imagining. The worked for me once and i was in highschool.
I understand your reservations about asking your husband for fear of a false answer. But if it is something that bothers you, you need to ask him. And you need to be prepared for his answer, you might not like his honest reply. So my advice to you would be to ask him that question, once you know you can handle any answer.
I just want to say that admire your courage to stand by him through this tough times, as long as you continue to be supportive of him and have his back, he will make it through.
I hope this helps and best of luck!
ICView Thread
Sadly for me this entire thing has been a double edged sword and dealing with depression for over 20 years and finding this fantasy world to get lost in. The fantasy world helps me deal with my depression because I dont think of being depressed. I can be something im not or what ever the other person wants me to be. Also i dont think about work or finances or what ever might be bothering me (triggers). But after imersing myself in that world for hours on end and waking up the next day i feel shame and guilt and regret and everything else that comes with it. So it just sinks me deeper into a hole. I have tried to stop and have had some success...a few weeks here, 6 months there. But i always came back to it, one of my many triggers is, boredom, I have a very active mind and if i am not doing anything i immediately want to go online.
Again with your husband and I dont know him personally, but his relationship with his parents sound pretty toxic. I love my mom and dad to death, but in small doses. It sounds like his mother doesnt do anything for you or him and im curious if its always been that way. Most people who are often made to fend for themselves come out strong independent people. But on the other hand, someone who is depressed or feeling worthless, because Mom isnt doing the motherly things he thinks she should. Can lead to him feeling, thinking he is worthless and that he is unloveable. And from what his Dad sounds like, he wasnt much help to his psyche either. Ultimately to me his issues seem to be deeply rooted in his childhood. You mentioned that when you were sick and in the hospital, that someone had to bring him food? Whether he can cook or not, he should be able to provide food for himself and his family. I might have read that wrong, if so i apologize. And based on what you said about his mom not pitching in, it seems to me that he got that behavior when he was growing up.
I know i didnt get to all your questions, but im running out of space and time. I will continue this post when i have a few more minutes.
ICView Thread
I understand what you mean, but there are varying degrees of having a "good time". Someone could go out and have a couple cocktails and unwind. On the other hand, someone could go out and drink a 12 pack or more to unwind. Some might say, the latter has a problem. Addiction is all about control, you thinking you have control over the substance/medium, but in reality the device has control over you. Based off of what the poster said and giving the past of the husband, is the reason i did suggest addiction. A crack addict, didnt go out looking to get hooked, he was looking for a good time. But because of the intense high you supposedly get the first time, they continue to smoke it, chasing that high. Most addicts look at their device as a way of escaping reality, so they dont have to deal with current events in their life.
But you are right, i shouldnt have labeled a complete stranger an "addict", but given my personal experience and hearing his story. I made the connection between the two of us, just because i have this particular addiction, doesnt mean that he does.
I hope they repost as well, sorry for any confusion.
ICView Thread
So when his brains starts to produce those pleasure chemicals, dopamine, etc. he reaches a point of euphoria or in his case orgasm. And im sure that the males in this group will agree, the first time is a pretty great feeling...almost euphoric.View Thread
Having had similar issues to your husband, i can relate to both topics. After examining the things i did to keep the porn hidden from my ex and how i was in denial of how much it played a role in my life. I came to the conclusion that i had/have a problem with porn. So much to the fact that just going onto the computer to look up a movie time or sports score, brings urges to look at porn. As for the ED i have had issues with that as well, given his job, i can clearly see how stress can be a major issue with this problem.
I, like your husband starting watching porn in my teens and as i got older the obsession grew. For me personally, there were other issues there, depression and self doubt the main ones. One of the things that happens when you use porn to "get off" is that you start to desensitize your parts, you get used to your method and that is what your body expects to feel during intercourse. Which we all know are two different feelings all together, but the brain attaches that stimuli(porn) to getting and maintaining an erection and it basically forgets how it was wired to think.
Over the past couple years i have began seeing a therapist for my issues and unfortunately there are many, lol. But dealing with my internet problem, has been the hardest thing to do. For me mainly its a way to forget about the stresses of life and i slip into my own little world, where ther are no problems. No issues with mom or what ever the case may be. I understand that because of his job it is hard to seek counciling, but would you be able to talk to the office and explain to them his situation and maybe use a psudonym? and dont use any insurance so it stays off of his medical billing history.
I do applaud you for being supportive and trying to appease his needs by dressing up for him, you have done more than most by just doing that.
Also, i completely understand how he feels when he says he feels ashamed of what he did. The next day or hours after, I feel absolutely horrible, because I know what i did is something that is holding me back. And by no means is it an easy conversation, it is hard for me to talk to my therapist about it and I usually have no issues telling her anything. But when i talk about porn, i see the look of disappointment on her face. And i agree with Darlyn, hanging divorce over someones head isnt a means to accomplish anything. If anything it will add more stress to your relationship, because he or the both of you might start walking on eggshells around one another.
I wish you the best of luck!
ICView Thread
ICView Thread
Your not being "dumb" or over analyzing anything, so give yourself a break When i was married this obviously was a topic that came up and the situation was similar to yours, my ex made more money than i did. When we bought our house it of course made sense to put all the cash in one spot. I was mortified to say the least. All my life it was "my" money and now its going to be "our"money. What we ended up doing was creating a joint account and we both opened up individual accounts at the same bank.
So you could have your own bank card and with technology you can move money back and forth between the two with the click of the mouse or tap of a smart phone. So when you get your budget together and include everything. All the bills, rent and have an idea for what you'd like to spend for fun or dates, etc. So if your budget is 1400 a month, you each could put in 350 a pay check. That way you'd still have your money to spend how you want and you took care of the financial responsibilities.
It will take some getting used to thats for sure, but if you care about this guy, which you obviously do. You'll find a way to make it work And when it comes to bdays and holidays, you'd still have your money to buy gifts and such.
Best of luck on the house and the finances!
ICView Thread
Steve and Quest make some really good points. There is a theory called Wilson's Syndrome or something to that effect(sorry its been a long day). But basically what it states is that over time a stimuli can become boring and the person looks for a new and exciting stimulation. In his case this could explain the shemale porn...Has he watched pornography for a long time? Over that time he could have just gotten bored with the "normal" stuff. As Quest mentioned, since he is bi-sexual, that does make sense as well.
The fact that he likes show tunes, doesnt make a man gay, thats a pretty big stereo type. He could just enjoy culture and arts, there is nothing wrong with that. As a matter of fact, there are many women out there who find that sort of trait sexy. Now the Bieber music...that has to STOP! lol j/k. I can understand your plight on this one, he is a grown man and really has no business listening to that drivel. However, the Bieb's is a talented individual, probably with the help of his sound techs.
From the sound of your post, it seems like you guys have a very healthy and active sex life. Its natural for you to have those types of concerns, but, you knew he was "bisexual" going into the relationship. And it also sounds like you two have a pretty good line of communication as well, you may just need to sit down and have a heart to heart conversation. He may not know exactly what your feeling and he may be able offer you some comfort and reassure you that, your the one for him.
Best of luck!
ICView Thread
Yes, i would say your in a bit of a pickle. But as you have grown close to this young man, do you think he is a good guy? Seems like he is really reliable and a hard worker. Sadly as I am sure you probably know, that you cant really pick who you fall in love with. It can just happen and even tho he said he never would date her, I dont know if you can hold that against him. For the simple fact that he probably had no intentions of dating her and then they got to know each other.
On the other hand, your daughter who just got out of a relationship, got involved with someone rather quickly, she may just be trying to fill a void. I dont think having a conversation with the guy is a bad idea...i wouldnt make it a threat. Just speak candidly with him, you two seem very close, he should appreciate that sort of honesty. You obviously respect him, so just tell him how you feel about the situation. Get his thoughts about whats going on in his head and where he stands on all of this.
Ultimately your daughter is an adult now and as much as she will always be your little girl, you have to cross your fingers that she listened to all advice you have given her in her lifetime. Given how quickly this guy began to look up to you in that sort of fashion, Im pretty sure you did a great job raising your daughter. The hardest part about being a parent is letting go and letting them fly on their own.
Best of Luck!
ICView Thread
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UPDATE: CPS supervisors being investigated for evidence tampering, no charges filed
Three Child Protective Services supervisors in Abilene are being investigated by the Abilene Police for possibly altering, destroying or concealing evidence in the death of a 22-month-old on Dyess Air Force Base.
Earlier update
The Abilene Police Department are currently on the scene of Abilene's Child Protective Services Office, 3610 Vine St., executing a search warrant as a part of the department's ongoing investigation of the alleged mishandling of a Dyess severe neglect case.
The case resulted in the death of a 22-month-old girl.
According to court papers, the department is looking for "any and all items related to the offenses of tampering with evidence."
A search warrant affidavit obtained by the Reporter-News states three CPS employees may have tampered with evidence in relation to the case. During the investigation, police say CPS workers were advised to be uncooperative with law enforcement.
According to the Houston Chronicle article published over the weekend, a Texas Child Protective Services supervisor allegedly closed out an 11-month-old investigation involving Tiffany Klapheke's daughter, Tamryn, on Aug. 22.
Throughout APD's investigation, 12 CPS employees that have knowledge about the case were interviewed. Court records state that the interviews then led police to believe that "several supervisors within the administration" of CPS "knowingly concealed, altered, and/or destroyed records and other documentation" material to the Klapheke investigation.
The Abilene Police Department say they are investigating the local Child Protective Services office following the discovery of a severe-neglect case at Dyess Air Force Base.
The Houston Chronicle first reported the information in an investigative article published on Sunday.
According to the article, a Texas Child Protective Services supervisor allegedly closed out an 11-month-old investigation involving Tiffany Klapheke's daughter, Tamryn, on Aug. 22.
On Aug. 28, the girl, along with her two sisters, were found to be neglected by their mother, Tiffany Klapheke. Tamryn was found unresponsive and not breathing and was transported to Abilene Regional Medical Center, where she later died. The two surviving girls remain in foster care.
Chief Stan Standridge said today he could not offer any more details into the investigation.
"I recognize the nature of this investigation and all of the complexities involved, but I cannot disclose any information that would be prejudicial to ensuring justice is accomplished," he said. "The department hopes to be able to provide updated information at a later time."
Click here for a link to the Houston Chronicle report.
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Wilson Two BLX Tennis Racquet
- Headsize: 110 sq. in.
- Length: 27.25 in.
- Weight (strung): 8.40 oz.
- Stiffness (Babolat RDC): 69
- Balance: 15.50 in. Head Heavy
- Cross Section: 26/28mm Tapered Beam
- Swingweight: 315 kg*sq. cm
- String Pattern: 16x20
- Grip: Wilson Comfort Hybrid
What is BLX?
Basalt is a natural volcanic rock used in manufacturing and made into fine and ultra-fine gold fibers. Basalt fibers are environmentally friendly and superior to other fibers in terms of thermal stability, sound insulation, vibration assistance and durability. With the new BLX line, Basalt fibers are woven longitudinally with the innovating [K]arophite Black to create the most advanced composite ever in the industry. Players will find the ultimate in frequency reduction while retaining the performance of carbon fiber in terms of lightness, responsiveness, stability and rigidity.
Basalt added into racquets filters out unwanted frequencies (i.e vibrations) that reach the hand to deliver a clean feedback and sensation for the perfect feel players demand.
- Overall Rating: 5.0 / 5.0
- Write a Review
amazing Racket
Where to start from? Amazingly Light Racket for anyone, stability, power and also control!! For me 5 starts as love the balance and the weight of this racket!! Have 2 now, same colour...
Light but Stable
light but still provides stability and power on volleys & serves!
GREAT addition to my tennis kit! I have been pleasantly surprised at the "lightness" of the racquet that still provides me with MORE stability and POWER on my volleys & serves!
Ver y good racquet
A very light racquet with good power. Really happy with my purchase
Nice racket!
I like the weight of the racket, I will have it restrung because it doesn't have enough pop on the ball with this tension.
Great light racquet
This racquet is a great value. I play twice a week and go back and forth with a light head that is smaller. The only thing I would change is the string. This is pre-strung and I prefer an NXT Power string. Go for it if there are any left.
Lightweight racket
With two shoulder tendons missing you have no other choice.
Two Too Good
BUY this racquet if like light-weight power, control, maneuverability and the current reduced price. I've gone through six rackets over the past six years, looking to modernize my old, lightweight Head Ti S6 that I've cherished for over a decade. Finally, I'm in love all over again. My opponents notice my new power, control and confidence on the court. My serves and volleys have new pop and consistency. My rallies are landing harder and deeper on the court, pushing opposing players back. An especially good racquet for aging baby boomers looking to restore some lost boom to their stroke.
Racquet Winner
Demoed racquet and from the start felt comfortable with power and zing. First week won 2 matches!! Has light feel and effortless swing. Good maneuver at the net. Like the 110 inch head size.


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STAR series to feature Dolney December 6
Thursday, October 4, 2012 - 869 hits
Timothy Dolney, assistant professor of geography, will present "Every Map Has a Story" on Thursday, December 6, 2012 from 12:10 - 1:00 p.m. in the Fireside Lounge of the Slep Student Center. His informal talk is part of the Spotlight on Teaching and Research (STAR) Series in which faculty share how their research influences their teaching, and vice versa. The series is co-sponsored by the English and Honors programs. Pizza will be served; attendees should bring their own drinks. The event is free and open to the campus community.
Media contact:
Marissa Carney, Media Relations Coordinator, University Relations 814-949-5105
Web Contact:
Jonathan O'Harrow, Webmaster, University Relations 814-949-5105
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- Vision & Strategy
- The Wisdom Agenda
- Excellence
- Research Integrity
- UCL Grand Challenges
- UCL Research Frontiers
- UCL Public Policy
- UCL Research Domains
- Impact
- Strategic Partnerships
- Access UCL Expertise
- BEAMS Funding Office
- SLMS Research Coordination Office
- Professor David Price, UCL Vice-Provost (Research)
UoA 22: Statistics
Research activity in the Department of Statistical Science at UCL covers a wide spectrum, ranging from development of generic statistical theory and methodology to applications in industry, science and medicine. There has been a significant level of collaborative and interdisciplinary research and the breadth of our research activities is reflected in the variety of our sponsors. The UCL element of new awards (individual and collaborative) associated with research active staff over the period was over £2.4M, including Leverhulme Trust/ESRC (£970K), DEFRA (x2) (£424K), EPSRC (x6) (£422K), DH (£157K), BBSRC (£136K), Cancer Research (£120K), Garfield Weston Trust (£102K), Leverhulme Trust (£98K), Bowling-Pfizer (£17K), NHS R&D (£10K).
Our research students have been funded by EPSRC, MRC, DEFRA, NMLC, EU, ORS and various foreign governments. Over 340 refereed journal papers (published from UCL) appeared in statistical and mathematical journals, including Ann. Statist., Biometrika, J.& A. Appl. Prob, J. R. Statist. Soc., Proc. Roy. Soc., Scand. J. Statist., Statistics in Medicine, and in numerous diverse outlets such as BMJ, Circulation, Forensic Science International, IEEE Trans. Signal Processing, J. Energy Engineering, J. Hydrology, The Lancet, Theoretical Population Biology. The statistical material in the latter category of papers ranged from original methodology and theory to substantive contributions to the discipline. Members of the Department (while at UCL) gave over 50 invited lectures at major international conferences and workshops and numerous presentations and seminars nationally.
Our research mission is to "identify, develop and apply the sound statistical foundations essential for advances in the physical, social, environmental and medical sciences". We aim to be world leading in foundations of statistics and generic theory and methodology, while making important contributions to key application areas.
Research in the Department is grouped under four broad themes (theme
leader starred, Early Career Researchers in italics):
- Foundations and Theory (Sweeting*, Dawid, Didelez) covers foundational aspects of probability and inference, particularly Bayesian theory, decision theory, predictive inference, probabilistic expert systems, graphical modelling, causal inference and event history analysis. The Leverhulme-funded interdisciplinary research programme Evidence, Inference and Enquiry (worth just under £1M) incorporates researchers from Economics, History, Medicine, Psychology, Philosophy, Education, Law and Forensic Science.
- Applied Probability and Stochastic Modelling (Isham*, Chandler, Galbraith, Guillas, Northrop, Wilkinson-Herbots) includes modelling and inference for spatial-temporal processes as a major component, with hydrology and climatology as important applied areas, with DEFRA, EC and the NERC/TSUNAMI consortium providing significant funding (almost £1M). Further important research concerns the modelling of geological processes, while theoretical research on epidemic models and genetics leads to applications in the life sciences and insight on biological mechanisms.
- Methodology and Applications (Fearn*, De Reyck, Hennig, Olhede, Siddiqui) includes estimation and inference for stochastic-mechanistic and large spatio-temporal models by the Stochastic Modelling group, adjustment for measurement error in epidemiological studies, signal processing, wavelet representations, image analysis and operational research. Core methodology for multivariate data features strongly, particularly cluster analysis, multivariate calibration, classification and analysis of high dimensional data. Other major application areas include mathematical biology, medical imaging, geophysics, chemistry, project portfolio management, energy economics and law.
- Statistics in Medical Research (Omar*, Ambler, Royston, Seaman, Senn) encompasses both applied health research and the development and evaluation of statistical methodology, with significant funding (c£700K) from DH, NHS R&D, MRC and various charities and pharmaceutical organisations. Current methodological topics include risk modelling of health outcomes, modelling clustered data, meta-analysis, evidence synthesis and Bayesian methods. Applied research has included developing and validating risk models, measuring variations in health outcomes, randomised trials, and large scale observational studies.
Download full text of the RA5a statement for Statistics & Operational Research (pdf 96Kb)
Staff names below link to submitted publications:
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Page last modified on 16 jan 08 01:34


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CAM on PubMed is a subset (a part) of all citations found on the NLM's PubMed and offers all of the features and benefits of PubMed.
Q: What is PubMed?
A: PubMed is a system of the National Library of Medicine (NLM) that provides an easy way to access over 11 million journal citations in the MEDLINE database and additional life science journals. NLM is the world's largest library of the health sciences, located at the National Institutes of Health. PubMed is free and searchable through the Internet. In addition, PubMed has a "LinkOut" feature that links a citation to outside sources for the full text of the article (some publishers may require a subscription or a fee); over 1,700 journals are linked. Another feature of PubMed, "Related Articles," lets you obtain a set of citations that are closely related to the selected article. NLM regularly adds new citations to PubMed.
Q: What is complementary and alternative medicine (CAM)?
A: NCCAM defines complementary and alternative medicine (CAM) as those healthcare practices not currently considered an integral part of conventional medicine. It covers a broad range of healing therapies, approaches, and systems. Some examples of CAM include acupuncture, herbs, homeopathy, chiropractic, hypnosis, and traditional oriental medicine.
A therapy is called complementary when it is used in addition to conventional treatments. It is often called alternative when it is used instead of conventional treatment. Most often, people who use CAM therapies are seeking ways to improve their health and well-being and to relieve symptoms and side effects of conventional treatment.
Q: Who will use this database?
A: CAM on PubMed will be used by researchers, CAM practitioners, health care providers, students, people with illnesses, their family and friends, advocacy organizations and many others as a resource to find citations related to complementary and alternative medicine. Please note that it is not the intention of the NLM or NCCAM to provide specific medical advice, but rather to provide people with access to sources of information.
Q: How many citations are included within CAM on PubMed?
A: Currently, there are over 220,000 citations in the CAM subset of PubMed (from 1966 forward). As research in complementary and alternative medicine grows and more articles are published in peer-reviewed journals, we expect the number of citations to increase.
Q: How do I access CAM on PubMed?
A: You can access CAM on PubMed from any computer with Internet access. You do not need to register.
You can find CAM on PubMed through the NCCAM Website or directly through PubMed. When searching from the NCCAM Website, your searches will be automatically limited to CAM-related citations. If you search directly from PubMed, you need to limit the search to the CAM subset. First, click on the "Limit" function. Next, select "Complementary Medicine" on the Subsets pull down menu.
Q: Where can I find help using CAM on PubMed?
A: To find help using CAM on PubMed, review the information under PubMed's Help and FAQ sections. This information is accessible from the sidebar while you are in PubMed. You may also e-mail NLM's customer service (firstname.lastname@example.com).
Q: How can I obtain more information about complementary and alternative medicine or learn more about the National Center for Complementary and Alternative Medicine (NCCAM)?
A: The NCCAM Web site, http://www.nccam.nih.gov, includes links to NCCAM program areas, news and events, research grants, funding opportunities, and other information about complementary and alternative medicine.
In addition, you may contact the NCCAM Clearinghouse for information at:
NCCAM Clearinghouse
P.O. Box 8218
Silver Spring, Maryland 20907-8218
Toll Free: 1-888-644-6226
Q: How do I learn more about the National Library of Medicine (NLM)?
A: The Library has an extensive Web site at http://www.nlm.nih.gov that provides a great variety of information for the general public and for health professionals. The site requires no registration and users are assured of complete privacy.


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Harley Sportster Engine & Parts
Brakes: single 292mm rotors at front and rear
Seat height: from 660mm (on 'L' version) to 693mm.
Dry weight: 251 kg
Price: new from $9000
Engine/transmission: 883cc air-cooled 45-degree V-Twin; 70 Nm @ 3,750 rpm; five-speed gearbox, belt final drive. The clutch has little weight and the sizeable, rubber-mounted 883cc engine has been perfected by years of modification by people who really know what they are doing! The end result is a power unit that preserves the classic silver, powder-coated image of the street machines whilst accomplishing a beautiful and sleek elegance. When you turn it over it sounds magnificent, defiantly a sound you want to hear! The enhancements to what used to be a hefty and also unmanageable heavy gearbox have executed a bike which looks awesome, sounds beautiful and handles like a dream..What more could you want?


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Monday, July 15, 2013
I have some very mixed feelings about a letter recently written to the U-B.
First off, I have tried to figure out exactly what the point of the letter was. Did Craig Buchanan want to inform the world that Muslims work for TSA? That is great. We have people on the front line who really care about our travel safety.
Did Mr. Buchanan want to let us know we have exchange students attending Wa-Hi who are Muslim? That is also great. It shows acceptance and understanding.
Did Mr. Buchanan want to let us know that he is accepting to all religions? I sure hope so. One thing everyone needs to learn is to have an understanding of differences of culture. Everyone needs to learn to have peace in their hearts. Everyone needs to have a heart full of goodwill.
In 1947 a group of volunteer ambulance drivers from World War I and World War II initiated student exchange programs to provide an avenue for peace, goodwill and cultural understanding.
This organization is American Field Service (AFS). In 1956, President Dwight D. Eisenhower initiated a sister city program to promote peace, cultural understanding and goodwill so we would not have to endure the waste of war. Walla Walla and Sasayama, Japan, have been sister cities for over 40 years. Long before either of the above two programs, Black Elk of the Ogalla Sioux proclaimed there would never be peace until there was peace in the hearts of mankind.
In the United States of America we are made up of a citizenry of every country in the world. We are made up of every religion of the world. We are made up of every ethnic background in the world. Within the United States of America most of us have learned to live in peace, attempt to understand the cultural differences, volunteer and promote goodwill.
Mr. Buchanan's expressions are not right, not wrong, but different.
Hopefully Mr. Buchanan can learn to respect the rights of others, appreciate their differences and learn as well as understand the cultural differences.
Robert Keatts
Chairman, Walla Walla-Sasayama Sister City Committee


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Use the tools below to refine your search by only displaying reviews with a certain number of star ratings or to only show reviews from a certain time period. Eg click on '1 star' to just display the reviews we have which received a 1 star rating click or 'Within the last month' to display just reviews posted over the last month.
Written on: 25/05/2009
fitting and unfitting parts on the Challenge Xtreme Blower Vac is almost impossible. they should twist on and off but take a superhuman effort. I tried to disconnect the suction tube (place on floor between feet and twist tube) Half an hour later still struggling. Drilled two holes either side of tube to increase leverage with iron bar but still would not move. Next place for it is down the tip tomorrow. Versatility is absolute rubbish… Read Full Review
Written on: 07/01/2008 by rexkeegan (1 review written)
Zipper on bag broke on second use of Challenge Xtreme Blower Vac. Have been trying to find a replacement bag since it broke, but so-far unsuccessful… Read Full Review
As rated by our community of reviewers
" Brilliant back up service " Read More
Written by jazzlover178
" Just won't start " Read More
" This is the second GW250 I've had. The first one died after a coupl... " Read More
Written by kiwiguy999
" Blower works well for my new backyard " Read More
Written by SRamirez
" (Not so cheap) rubbish " Read More
Written by Mysteriousbananaman


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What is pastebin?
pastebin is here to help you collaborate on debugging code snippets. If you're not familiar with the idea, most people use it like this:
- submit a code fragment to pastebin, getting a url like http://pastebin.com/1234
- paste the url into an IRC or IM conversation
- someone responds by reading and perhaps submitting a modification of your code
- you then view the modification, maybe using the built in diff tool to help locate the changes
How can I view the differences between two posts?
When you view a post, you have the opportunity of editing the text - this creates a new post, but when you view it, you'll be given a 'diff' link which allows you to compare the changes between the old and the new version
This is a powerful feature, great for seeing exactly what lines someone changed
How can I delete a post?
If you clicked the "remember me" checkbox when posting, you will be able to delete post from the same computer you posted from - simply view the post and click the "delete post" link.
In other cases, contact us and we will delete it for you
What's a private pastebin and how do I get one?
You get a private pastebin simply by thinking up a domain name no-one else is using, e.g. http://private.pastebin.com or http://this-is-my.pastebin.com. Posts made into a subdomain only show up on that domain, making it easy for you to collaborate without the 'noise' of the regular service at http://pastebin.com
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You are hereHome ›
Narrow Search
Now showing results 1-10 of 14
This is an online lesson associated with activities during Solar Week, a twice-yearly event in March and October during which classrooms are able to interact with scientists studying the Sun. Outside of Solar Week, information, activities, and... (View More) resources are archived and available online at any time. This is an activity about measurements of solar activity. Learners will observe an image of the Sun and sketch major features, plot data to begin to recognize patterns of solar activity, look for long-term patterns in graphed data, compare X-ray and visible light images of the Sun to find solar features common to both sets of images, and make a prediction of what the Sun will look like in a visible light image after observing an X-ray image taken on the same day. This activity is scheduled to occur during Monday of Solar Week. (View Less)
This is an activity about satellite flight. Learners will first watch a video about the orbit and formation of the MMS satellites to learn about their flight configuration. After, they will research similar facts about other types of satellites.... (View More) Next, learners will compute the volume of MMS' tetrahedral flight configuration and investigate how the tetrahedral volume changes as the satellites change positions. Finally, they will create a report that outlines their findings.This activity requires student access to internet accessible computers. This is lesson three as part of the MMS Mission Educator's Instructional Guide. (View Less)
This is an activity about solar energy. Learners will first use computers to research and learn how solar panels convert sunlight into electricity. Next, they will calculate the surface area of solar panels board a satellite and their total power... (View More) generated in various positions of the satellite, given the dimension of the panels. After, learners will organize and write a report summarizing the information about the MMS mission satellites. This activity requires student access to internet accessible computers. This is lesson four as part of the MMS Mission Educator's Instructional Guide. (View Less)
The 9-session NASA Family Science Night program invites middle school children and their families to discover the wide variety of science, technology, engineering, and mathematics being performed at NASA and in everyday life. Family Science Night... (View More) programs explore various themes on the Sun, the Moon, the Stars, and the Universe through fun, hands-on activities, including at-home experiments. Information about Family Science Night implementation and support resources, including the facilitator's guide, are available by registering on the Family Science Night Facilitators website (see Related & Supplemental Resources for link). (View Less)
This is an activity about solar flare activity. Learners will use whole-Sun maps of magnetic activity in order to identify possible future magnetic activity. They will take into account the rotation of the Sun and make day-to-day predictions of the... (View More) overall Earth-side magnetic activity as suspected farside features rotate onto the Earth-side, and as Earth-side features rotate out of view onto the farside. Finally, learners will check the accuracy of their predictions. This activity requires access to the internet to obtain images from the Stanford University solar magnetic map archive from 1996 to 2011 and the GOES X-ray image archive. This is Activity 9 of the Space Weather Forecast curriculum. (View Less)
Materials Cost: Free
Using Mathematical Models to Investigate Planetary Habitability: Activity C The Role of Actual Data in Mathematical Models
Students explore how mathematical descriptions of the physical environment can be fine-tuned through testing using data. In this activity, student teams obtain satellite data measuring the Earth's albedo, and then input this data into a... (View More) spreadsheet-based radiation balance model, GEEBITT. They validate their results against published the published albedo value of the Earth, and conduct similar comparisons Mercury, Venus and Mars. The resource includes an Excel spreadsheet tutorial, an investigation, student data sheets and a teacher's guide. Students apply their understanding to the real life problem of urban heat islands and deforestation. The activity links builds on student outcomes from activities A and B: "Finding a Mathematical Description of a Physical Relationship," and "Making a Simple Mathematical Model." This is Activity C in module 3, Using Mathematical Models to Investigate Planetary Habitability, of the resource, Earth Climate Course: What Determines a Planet's Climate? The course aims to help students to develop an understanding of our environment as a system of human and natural processes that result in changes that occur over various space and time scales. (View Less)
Materials Cost: Free per student
This is an activity about the planet Mars. Learners will create cratered surface models illustrating different lengths of time. Then, they will compare their models with three different surface images of Mars, placing these images in order from... (View More) youngest to oldest based on the evidence. Learners will discover that the oldest surface has the most craters, while also discussing what events could make a surface on a planet both half-craters and half-smooth. (View Less)
This is an activity about the movement of a coronal mass ejection. Learners will plot the path of two coronal mass ejections (CMEs), both the distance traveled and the increasing angular width, as they leave the Sun and travel outward through the... (View More) Solar System. Then, they will sketch the path of the CMEs and identify the location on the Sun from which a CME would need to leave in order for it to hit Earth. This is the first activity in the Solar Storms and You: Exploring the Wind from the Sun educator guide. (View Less)
This is an activity about telescopes. Learners will first measure several circles to determine their diameters and calculate their areas. Afterwards, they will cover each circle entirely with pennies and record how many pennies are needed for each... (View More) circle size. The concept to be explored is that a telescope with a larger lens or mirror is able to collect more light than another telescope with a smaller-diameter lens or mirror. This is Actividad 10.2 as part of El Universo a Sus Pies, a Spanish-language curriculum, available for purchase. (View Less)
This is an activity about telescopes. Learners will first measure several circles to determine their diameters and calculate their areas. Afterwards, they will cover each circle entirely with pennies and record how many pennies are needed for each... (View More) circle size. The concept to be explored is that as the diameter of a telescope lens or mirror increases, the telescope is thus able to collect more light. This is Activity J-1 of Universe at Your Fingertips 2.0: A Collection of Activities and Resources for Teaching Astronomy DVD-ROM, which is available for purchase. (View Less)


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October 13, 2015
A Pike County jail escapee and his wife who police say helped him are both indicted.
Nacomah Harmon and Kaitlyn Charles Harmon are charged with escape.
Nacomah Harmon also has persistent felony offender charges.
Police say on October 26th, Nacomah Harmon was out on work release hanging up Christmas lights outside the courthouse when his wife drove up, he got in the car, and they drove away.
The couple was caught and arrested last week.
Click Here to access the online Public Inspection File
Viewers with disabilities can get assistance accessing this station's FCC Public Inspection File by contacting the station with the information listed below. Questions or concerns relating to the accessibility of the FCC's online public file system should be directed to the FCC at 888-225-5322, 888-835-5322 (TTY), or firstname.lastname@example.com.


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See All Contributors »
I don't have time right now but I've thought it would be nice to know other languages. I've seen ads for RosettaStone on tv a lot over the years and they seem to have some large entities that use their product and wondered if anybody here had every used their product?
I took two years of Spanish in HS but don't really remember any of it so I'm sure it wouldn't be too difficult to learn it but I also don't want to dedicate a ton of time to it when I do eventually get around to it.
Sometimes it is the people who no one imagines anything of who do the things that no one can imagine.
ISU MBB: Bigger than a single person.
ISU Football: They key to expectations is not having any in the first place.
I've thought about it several times. I'd assume it works, just based on the cost. You charge $200 for something and it doesn't work as advertised....you're not going to be in business very long.
*Edit: Found some reviews (for Spanish)
Rosetta Stone Spanish Review 2008
Last edited by superfan; 01-26-2008 at 11:33 AM.
I was given a copy of RosettaStone for Spanish. It's pretty cool but, like you, I rarely have time to use it. The little time I have spent with it has been pretty productive but not sure it's worth the money.
I've look for these on ebay and craigslist for a discounted price, but no luck. Anyone else seen them for less? Do you think the local library would have them?
Our public library (St. Paul) has the Rosetta Stone software online free for patrons...all you need is your library card. It might be worth it to check bigger library systems like Des Moines to see if they offer it, and if they don't suggest it.
Forever trying to find a cure for the Dunning-Kruger Effect.
Up until October of last year, Rosetta Stone provided online access through public libraries. We could get it through the Arlington Public Library, and you could access it from home with a username and password. Unfortunately, they seem to have discontinued that service, at least here...
"Don't worry Boss...they can't do nothin' 'til they're through sparklin'..."
Avatar - America's new superhero...Cenex Guy
Just drive thru McDonalds and you can learn a lot ordering.
Let Prohm's Posse Ride: Georges, Georgios, 3sus, Hallice, Deonte, Abdel, Monte, Matt, and McKaT.
I use it for German. It is good, but you really have to commit the time. I worked on it for Latin for a while, and it was pretty good.
I've used Rosetta Stone for German and Greek. It's very good, especially if you've ever learned a language before.
Be prepared to be confused, initially; it uses a fairly unique (but effective) method of teaching.
Originally Posted by Phaedrus
I've used Rosetta Stone for German and Greek. It's very good, especially if you've ever learned a language before.
Be prepared to be confused, initially; it uses a fairly unique (but effective) method of teaching.
You like the Greek? I was considering getting it for Greek later.
I've looked at this many different times, the only thing holding me off being the cost. Wanted to find out from someone who had used it. Now I will seriously check it out. Call me crazy, but I've wanted to learn Swahili for years.
Originally Posted by LindenCy
You like the Greek? I was considering getting it for Greek later.
How, precisely, do you mean that? "you like the Greek" can be "fighting words" in some quarters.
Yeah, I like the Greek version of Rosetta Stone. Greek is an easy language to learn, compared to others. Very logical and very familiar, as our language has a Greek base.
Les cyclones ne jouent pas au Mexique ne vous en inquiétez pas ainsi
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text: Members of the Future Business Leaders of America organization from East Carbon High School display a tarp which they signed and sent to Iraq. The banner was sent to Kyle Behling who has been serving in Iraq for the past several months as a Sea Bea in the Navy. Behling was excited to receive the tarp and said that it came in handy to provide shade from the hot desert sun.


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In 2015, WFP is providing lifesaving assistance through an Emergency Operation (EMOP) to respond to the immediate food and nutrition needs of 1.4 million people affected by conflict in South Sudan. The agency is also providing regular food rations to a pre-existing caseload of more than 200,000 Sudanese refugees in camps in Unity and Upper Nile states through a Protracted Relief and Recovery Operation (PRRO).
WFP is looking to ensure that we provide hope through our resilience activities – food for assets, cash for assets, Purchase for Progress, and food for education (school meals and girls' take home rations) – in relatively stable areas where we have access, food stocks and security. In 2015, WFP plans to reach 1.6 million people in this manner.
WFP's aviation team manages three complementary air operations – the UNHAS common passenger service, cargo aircraft to move WFP food and nutrition supplies, and more cargo aircraft to move humanitarian supplies for all agencies through the Logistics Cluster. The current small fleet of 13 aircraft dedicated to moving food supplies has the capacity to carry 300-400 metric tons of food per day.
WFP is working with the Government of South Sudan to construct feeder roads to link remote, agriculturally productive areas to main roads and markets. The Feeder Roads operation also links communities to basic services.


text: New Hartford Police [ Utica Woman Arrested For Endangering Child By Jim Rondenelli January 23, 2014 A Utica woman who allegedly left her 5-year old daughter outside in sub-zero temperatures is facing charges. Read More|Comment Category: Utica-Rome News Tags: endangering the welfare of a child, mahelia manuel, new hartford police Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


text:
Application Information
Scholarship Overview
This program is for residents of Arizona who are current or former foster students. To qualify, applicants must meet one of the following conditions: 1) were in foster care on or after their 16th birthday; or 2) were adopted from foster care with the adoption finalized after their 16th birthday. Applicants must be US citizens or qualified non-citizens; be younger than 21 to apply for the first time; and have been accepted into or be enrolled in a degree, certificate, or other accredited program at a college, university, technical, or vocational school. Applicants' personal assets (bank account, car, home, etc.) must be worth less than $10,000. Funding is limited and available on a first-come, first-served basis to eligible students.
How easy is it to apply?
This scholarship has application requirements that could take a lot of time and effort.
How much competition is there?
Not much
This scholarship won't have as many applicants as most.
Maximum Age: Is this you?
- 21
Class Year: Is this you?
- High school senior
- College freshman
- College sophomore
- College junior
- College senior
Home State: Is this you?
- Arizona
Other Qualifications: Is this you?
- Foster Care / Orphan


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Reference index for {HH}
You are viewing package members beginning with the letter "D"
|datasets {HH}
|Datasets for Statistical Analysis and Data Display, Heiberger and Holland
|dchisq.intermediate {HH}
|Intermediate f and chisq functions to simplify writing for both R and S-Plus.
|defunct {HH}
|Defunct Functions in Package 'HH'
|diag.arma.loop {HH}
|Loop through a series of ARIMA models and display coordinated tables and diagnoastic graphs.
|diag.maybe.null {HH}
|Returns a value for the diagonal of NA and NULL arguments.
|differential {HH}
|Diverging stacked barcharts for Likert, semantic differential, rating scale data, and population pyramids.
|do.formula.trellis.xysplom {HH}
|Interprets model formulas for xysplom and extended bwplots


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Our day kinda looked like this ::
The morning started with seeing what the sleepy fairies brought the little one. Sasa went to work super early for our town's yearly "Early Bird Sale" which meant whoever could wake up and go shopping in your pajamas at 6 a.m. got quite a deal. The little one and I were semi-early birds, but we still had to get through our morning routine before we left. Sasa? He was up at 4:30 today! Poor guy!
We had a visit from one of our favorite friends who joined us for painting day. We introduced purple today (guess who requested that?!) and painted quite a few pictures. We had applesauce bubbling away on the stove and all sat down for a nice snack after. The little one loves to "turn" the sauce in the mouli mill.
We were headed to the big city tonight for a special family dinner at my mother's house. The little one got nice and clean before we left and ended up spending an hour and a half in the tub! Just long enough for me to read through my new camera manual and figure out that silly video recording feature. I had no idea it would be so much fun!! Maybe you'll be seeing videos soon...
And we enjoyed a lovely evening at Baba's. Now we're home, ready for bed, and off I head to work tomorrow bright and early.
I hope you are all enjoying your weekend!


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Thursday, April 30, 1998
4:00 PM Eastern Time
NCI Press Office
(301) 496-6641
In this week's issue of Science*, a team of researchers report an exciting new lead. The group found, through a combination of luck and elegant science, that lethal factor goes after a signaling protein, known by the tongue-twisting name of MAP kinase kinase (MAPKK), and snips it in two.
Nicholas Duesbery, Ph.D., lead author of the study, and George Vande Woude, Ph.D., senior author, both with ABL-Basic Research Program in Frederick, Md., which is operated by a National Cancer Institute contract, said they think that this finding has important implications for developing new therapies for anthrax. They believe that knowing where lethal factor strikes provides a new focal point to develop rational strategies that block the enzyme from ever reaching MAPKK. Until now, scientists have relied on traditional vaccine approaches of teaching the immune system to recognize anthrax as an invader.
The scientists said their work establishes that lethal factor is a protease, an enzyme that clips proteins in two. They noted this finding could prove to be important because scientists have learned a great deal about proteases over the last decade while developing drugs that inhibit these enzymes in HIV. "This could be another example of how an investment in the basic sciences can pay off in unexpected ways," said George Vande Woude, Ph.D., director of the ABL-Basic Research Program.
"This work provides important biological insights with potential practical applications," said Richard Klausner, M.D., director of the National Cancer Institute. "It is exciting that, in this case, we now have a molecular target in sight that we might be able to exploit to thwart the deadly effects of anthrax."
Anthrax is a naturally occurring disease caused by the bacterium Bacillus anthracis. Spores from the bacterium enter the bodies of animals or humans, causing an infection. As the spores germinate, they release a toxin that can be extremely deadly, particularly if the spores are inhaled or ingested.
In the United States, about five new cases of anthrax are reported each year, with this figure rising to about 2,000 to 5,000 per year worldwide. Most of these cases involve the less-lethal cutaneous form of the disease, in which the spores enter the body via cuts or abrasions on the skin. However, in recent years, the emergent threat of a mass-produced, aerosol form of anthrax being employed as a biological weapon has been recognized. Though an anthrax vaccine exists, experts say new approaches to combat the disease would be invaluable.
Duesbery and Vande Woude set out to find a compound that worked in ways similar to a commercially available inhibitor of the MAP kinase pathway, called PD09859. Following a screen of the National Cancer Institute's 60 cell line in vitro anti-neoplastic drug database, the late NCI scientist Kenneth Paull, Ph.D., came up with lethal factor as a match. This unexpected piece of information suggested that lethal factor might also selectively inhibit the MAP kinase pathway.
The team's next task was to see if this was the case. They contacted Stephen Leppla, Ph.D., an author on the paper and an internationally recognized anthrax expert at the National Institute of Dental Research, part of the National Institutes of Health, to obtain purified lethal factor. Then, in a series of experiments, the scientists were able to demonstrate that lethal factor interacted with the MAPKK1 protein--a key component of the MAP kinase pathway--in frog, mouse, and human cell lines.
But they also noticed something interesting. Their data suggested that lethal factor might be a protease that inactivates the MAP kinase pathway by cleaving MAPKK. Duesbery and Vande Woude then contacted a long-time collaborator, Natalie Ahn, Ph.D., an author on the paper and a scientist at the University of Colorado, and asked for a purified protein that could be used in assays to follow up on this lead. Ahn sent what is known as a MAPKK1 fusion protein that was tagged with a known sequence of amino acids near the protein's so-called NH-2 terminus. Here, the group got lucky--the tag was close to where lethal factor cleaves the protein. "It turned out that having the tag at the NH-2 terminus made it much clearer that MAPKK1 was being cut into two pieces," said Duesbery. "If by chance, the tag had been placed on the C terminus, we would have had a tougher time detecting the change in the protein's molecular weight that told us this was the case."
Knowing approximately where lethal factor clips MAPKK1, the group was able to pinpoint in a series of experiments the precise cleavage points on both MAPKK1 and a related protein, MAPKK2. "The 60 cell database and Ken Paull's work were essential in making the first step," said Duesbery. "And once we made the first step, everything flowed after that. It really shows the power of databases in providing unexpected leads that make serendipitous discoveries like this possible."
* The study is titled, "Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor." The authors are Nicholas S. Duesbery, Craig P. Webb, Stephen H. Leppla, Valery M. Gordon, Kurt R. Klimpel, Terry D. Copeland, Natalie G. Ahn, Marriane K. Oscarsson, Kenji Fukasawa, Ken D. Paull, and George F. Vande Woude.
Note to Reporters:
For more information about cancer, visit NCI's Web site for the media at
http://www.nci.nih.gov. Other information is located at http://rex.nci.nih.gov or
NCI's main web site at http://www.nci.nih.gov.


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Kambi warns workers affiliated to COTU against strike
Labour Cabinet Secretary Kambi Kazungu has warned all workers affiliated to the Central Organization of Trade Unions (COTU) against downing their tools come August 4th as directed by the leadership of the giant union.
In issuing the warning, Kazungu said workers can only resort to industrial action if the available constitutional channels have been exhausted.
COTU is pushing for the reinstatement of its boss Francis Atwoli to the NSSF Board of Trustees, failure to which it says it will call for a nationwide strike.
Atwoli and the Federation of Kenya Employers Executive Director Jacqueline Mugo have since been reinstated by the Industrial Court, albeit temporarily. The temporary reprieve notwithstanding, Kazungu has termed COTU's strike notice ill-timed.
The CS who has been at crossroads with Atwoli for quite some time now, says there are many avenues for the workers to channel their grievances, adding that strike threats can only be used as a weapon of last resort.
COTU affiliate unions have demanded reforms at the NSSF before allowing their members to effect the increased 6% contributions to the pension Fund.
Elsewhere, over 500,000 elderly persons countrywide are set to benefit from the government's Older Persons Cash Transfer programme this year. Under the programme that was launched by Labor Cabinet Secretary Kambi Kazungu, each beneficiary will be paid a stipend of 2, 000 shillings per month, backdated from February to June this year.
Since its inception in 2007, the older persons cash transfer programme has benefited over 164,000 people countrywide, with a total of 500,000 elderly persons expected to benefit this year.
In the meantime, the General Assembly of International Conference on Great Lakes Region Summit is underway in Nairobi.
Kambi speaking while launching the conference hinted that the government is currently holding negotiation of bilateral labor agreements with other countries to ensure fair labor conditions are adhered to.


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comments sponsored by
Bar Exams, Kids, Politics, Trusts and Estates, Weirdness
Remember the alleged South Carolina bar exam shenanigans, which we discussed in these pages last week? There are some updates. See the links collected below, including a fairly barebones statement from the South Carolina Supreme Court.
Also, here's what appears to be an interesting email that made the rounds in the wake of the results announcement. It was purportedly sent by one of the test takers who initially failed to other individuals who sat for the S.C. bar exam:
Hey Y'all,
First of all I'm so sorry about the bar exam. This sucks. I need to know if any of you failed the Wills part of the exam and your score.
My Dad and [redacted's] dad have been on the phone with the powers that be, and if we can get a big enough group together that failed the Wills section they are going to take it to the Sup. Ct and see if they'll regrade our exams. Apparently, the examiner for the Wills section has been asked not to come back. We have a slim chance, but I think that it is worth it.
So far I have a list of 10 people that have failed the exam. They are [names redacted]. If you all know of anyone else that failed the Wills section PLEASE let me know so that we add them to the list. The scores are important too because we need to show the court how outrageous they are. Again, I'm so sorry we all failed. I really can't believe it.
Law Clerk
Please do not identify any individuals by name in the comments. Thank you.
South Carolina Bar Examination Weirdness [Feminist Law Professors]
S.C. High Court Responds to Bar Exam Flap [FITSNews]
Supreme Court Issues Statement Regarding July 2007 Bar Examination [South Carolina Judicial Department]
Bar exam appeal route urged [The State]
20 years ago, state official's daughter got score changed [The State]
Earlier: What's Up With the South Carolina Bar Exam?
comments sponsored by


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Album Rating: 4.0Good review. This is another great D album for sure, but I think I must have missed something but not having seen the movie. Plus, the CD is way short. Good stuff though with all said and done.
coherance is gay andy is the gayest member with jason comeing second then phil and then kevin last. Andy sucks at guitar and phil sucks him of while he plays guitar.
Album Rating: 3.0Come on, this album really isn't particularly amazing. It has it's funny moments for sure (love Classico and The Government Totally Sucks) but the music isn't as good and it makes no sense as an album, some of the tracks make no sense, I assume because they're just straight from the soundtrack. Not a proper album, seems like more of an extra to the film.
Album Rating: 3.5I just watched the movie, and the album makes a lot more sense now. Plus, some of the parts are freakin hilarious.
Album Rating: 4.0Jack Black always makes me laugh my ass off.
I love this so much, and I haven't even seen the film.
Album Rating: 3.0Extremely crude and goofy. There are some great songs actually.
Ive listened to it a few times today, And realized that i really really dont like it. Doesnt have the amount of creativity showcased in the first album.
I love this movie! :D
Really annoying movie.
The movie was actually pretty damn funny. 'Master Exploder' is such a fun song.
Digging: Digger - Powerbait
Movie was awesome, what are you talkin about Slaapkamers?
Album Rating: 3.5Great album, great movie and nothing can kill the metal.
Digging: After Dinner - Paradise of Replica
I still haven't seen the movie, but I have the pick thats on the cover.
Album Rating: 3.5I suggest you get it. One of the most important films of the new generation. Dio sings from a poster. Cock Pushups. F***in metal.
I'll go rent it tommorow when I go out to buy that daylight dies cd.
Album Rating: 3.0Few of the songs are too short but pretty good overall. I think their s/t is a little better, but there are two or three on here that are definate face melters.
Finding The Metal in GHIII was intensly funny.
Album Rating: 4.5well done
shows the biased manners of many who see pointless ties such as TD as great many of whom should try to expand the proverbial and theoretical horizons...
Album Rating: 4.0Great album! We need a good laugh in rock, especially when so many talentless bands take themselves so seriously, here we have talent having absolute fun. After all isn't that what it's all suppose to be about ?
Bands: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z


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Census figures show that Houston has reached a population of about 2.1 million residents, the trigger point necessary for adding two additional council district seats.
Ronald Green is Houston's city controller. He says until 1971, the makeup of council was all male and all white. The 1979 ordinance called for a change.
"As the city began to become more diverse, then certainly those diverse groups sought more representation. We've got populations that don't speak English as a first language, and so some of those areas make up a district of their own, potentially. So that's why you went to the district council member system."
Related Links:
The building services director is now doing an assessment of the available space at city hall for the addition of two new offices. Green says the cost will be about 400-thousand dollars for each new district:
"Some of the offices may be a little smaller. But I think that once we get the architectural plans in order, I think the citizens of Houston will know that the money was well spent."
While the vote to expand council was not unanimous, Green says the extra money needed to add districts J & K will benefit the city in the long run.
"What it essentially boils down to is that, I think, you probably will see a faster response time. The other side of that is there will be more services, but the general idea behind the population growth is that we could probably be eligible for more federal funding. Obviously at the end of the day, we hope that the benefits will end up happening as well."
Council will vote on the new district lines in May followed by approval of the Justice Department, and before the election filing deadline in September.


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Select Local Merchants
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Price Upon Request: See the Season's Most Over-the-Top Fine Jewels
Bobby Doherty shoots extravagant jewelry in unexpected ways.By Bobby Doherty
Bobby Doherty shoots extravagant jewelry in unexpected ways.By Bobby Doherty
E. Jean Carroll's old-timey plan for modern dating.By Maggie Lange
Changes at two of the city's most exclusive addresses.By Véronique Hyland
Warm, fuzzy feelings guaranteed.By Julie Ma
Tiffany & Co.'s lawyers feel otherwise.By Delia Paunescu
The jewels were custom-designed for Daisy, not Carey.By Julie Ma
Including Doutzen Kroes, Carey Mulligan, and Jessica Biel.By Jenni Avins
And wore nothing underneath.By Julie Ma
Elsa Peretti has renewed her contract with Tiffany & Co.By Charlotte Cowles
Plus, Carolyn Murphy and Sui He star in the holiday ads for Printemps.
They've commissioned Jude Law's sister to decorate it.By Charlotte Cowles
Brooks Brothers made them.By Charlotte Cowles
The company is trying to acquire the designer's intellectual property rights.By Hilary Moss
Plus, inside Tommy Hilfiger's Plaza home, why new model Lara Mullen needs Google Alerts, and more fashion news.
Plus, Coco Rocha covers the new issue of Canadian fashion magazine Flare.
Plus, Vivienne Westwood launches a new campaign to save the rainforests, Betsey Johnson's pink Christmas tree, and more news.
Just in time for all the tourists.By Ally Betker
They're onboard with the idea that a color can be trademarked.By Charlotte Cowles
Also, Burberry has been named the most "digitally competent" fashion brand by an NYU think tank.
Which has everything to do with Vogue, the CFDA, and the Met Gala, of course.By Charlotte Cowles


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Happy Weekend!
in Babblings
Happy Weekend!
Thanks for always making my work week so much fun with your comments and great feedback!
See ya Monday!
-the Muse
1/19/08 19:02 petitebelle:
ooo I absolutely love your blog!! So many pretty visuals and funny commentary. Keep it up! Hope you don't mind me linking you
1/22/08 9:17 the Muse:
Hi there!
I love yours too!!!!!!!!! Thanks for the link! I'll link you too