text:
Cancellation Policy
Bed & Breakfast Description
Innisfree Bed and Breakfast is a large Niagara escarpment home, with a relaxed atmosphere in the heart of Tobermory. Innisfree offers a spectacular view of Little Tub Harbour, the Ontario Northland's Ferry Dock, neighbouring islands and famous Georgian Bay sunsets. Our home offers five cozy bedrooms, three rooms with ensuite bathrooms and two rooms which share between them a large four piece bathroom. The Great Room with a fireplace and TV joined to a Sunroom. Two decks with sunset views. In the Sunroom you can enjoy a hearty Breakfast from 8:00 to 9:00 am.
Innisfree is surrounded by Tobermory's greatest attractions including the Bruce Trail entry point, Fathom Five National Marine Park, Flower Pot Island, Bruce Peninsula National Park and the M. S. Chi-Cheemaun Ferry. Other activities include hiking, boating, fishing, sightseeing, tours, shopping, kayaking, golf, wildlife observing and scubadiving. Innisfree Bed and Breakfast is open from May through to October.
Please visit our website at www.tobermoryaccommodations.com for online booking and more information.
For festivals and events within Tobermory visit Chamber of Commerce website,
Other Policies:
Check in time 3:00pm (15:00 hrs) to 7:00pm (19:00hrs)
Arrivals after 7:00pm (19:00hrs) must be pre-arranged
Check out time 10:00am (10:00 hrs)
Use of the kitchen is not permitted
No children under 10 years of age
Bed & Breakfast Rooms & Rates
Bed & Breakfast Directions
From Hamilton, Kitchener, Guelph area, take Hwy 6 North to Tobermory. Call for more directions.


text:
DeployStudio Server (was DeployStudio) helps system administrators save time with daily concerns, especially those caused by the increase of minor interventions requested by end-users: accidentally modified system preferences, third-party applications instability or misconfigured, wrong access rights, viruses, etc. OS X is stable and robust, but the capacity to (re)install completely a workstation or a server in a few minutes following a preset workflow that automatically restores the right disk image, configures and backs up what was planned by the administrator is a real benefit in terms of time and money. DeployStudio more...
What's New
- Improved user credentials check.
- Enrollment profiles detection.
- Text automatic substitutions disabled when editing scripts.
- Expanding nested workflows.
- Disk images upload progression fix.
- Configuring repository with smb url scheme.
- 10.7 ARD support.
- OS X 10.6.8 or later

subset: commoncrawl


text:
« The Big Picture |
| Blogroll Update »
Posted by Derek
So, as reader CalProf asked in a comment the other day, what should academic scientists who want to help discover drugs be doing?
As a first approximation, I'd say not drug discovery. That sounds a bit strange, I know, but there are some good reasons behind it. Modern drug discovery takes a lot of resources, from several rather widely separated fields, and it's not easy to bring all the necessary people together in an academic environment. You need med-chemists to make the compounds, pharmacologists and molecular biologiss to develop and run the primary and secondary assays, in vivo people to dose and evaluate effects in the animal models (which they'll also need to develop, in many cases), toxicologists, formulation chemists, computer modelers, scale-up chemists. . .and it's a great help to have people in each of these departments who've done this kind of thing many times and know all the obvious pitfalls. It's a lot easier to organize this as a company where everyone is hired to do their specialty, rather than try to run it with whatever post-docs and grad students you have handy.
But that doesn't mean that academia can't play a big role. They already do, of course, in doing much of the basic biochemical research that leads to new drug targets. Unraveling which protein interacts with which in some important cellular process is as basic as it comes, and most of the time that won't lead to drug one - but once in a while those experiments will set the entire industry off on a chase.
Another place where some academic thinking could come in very useful would be in attacking the important pharmaceutical processes that we don't understand: things like pharmacokinetics, oral availability, human versus animal toxicology, and (lots of) better disease models. The inefficiencies in these areas caused by our lack of knowledge are costing everyone billions of dollars - any improvement at all would be good news. Of course, it's not like the industry hasn't taken a crack at them, too (after all, there are those billions of dollars out there to be rescued from the bonfire). But we really need every approach we can get, and some fresh thinking would be welcome.
Want some more in that vein? Better ways to dose large proteins. New formulations, so that insoluble gunk like Taxol could be given in a dosing vehicle that doesn't occasionally give people anaphylactic shock. Some hope of predicting blood-brain barrier penetration. More understanding of active transport of drug-size molecules, and how it varies between species and among different cell types. Make no mistake, these are hard problems. But whoever can make real progress on them will get plenty of recognition, plenty of funding, and will be a flat-out benefactor of humanity to boot.
Comments (35)
+ TrackBacks (0) | Category: Academia (vs. Industry) | Drug Development
1. milkshake on January 28, 2007 9:54 PM writes...
Academia should develop tools for research, not products.
It is also bad training for the poor postdoc/student to be asigned making the methyl/ethyl/propy/isopropyl analog series - and he then even cannot even present his unimpressive work when looking for a job (because their patent did not get published yet.)
The institute where I work is actualy pretty good at bringing people from different fields together - most of these people were hired from industry with specific intention of getting a drug discovery site up and running. But is non-typical situation - what happens more often in academia is that a chemistry professor is hiring biologists or biology professor getting chemists, with predictable results and nobody has a clue about late stage PK optimisation.
If one likes to start doing drug discovery in academia, one needs financial backing and manpowere at least comparable with a startup company. One should also take maximum advantage of industry experience. Hiring people fresh from shcool won't do.
2. eugene on January 28, 2007 10:33 PM writes...
Perhaps there is a case to be made for a 'national drug company'? Sam's Pharma. With a mandate from congress and an independent board of directors.
3. Milo on January 28, 2007 11:04 PM writes...
What I think needs to be remembered is that in order to deconvolute many enzymatic pathways, a specific inhibitor is often needed. Therefore, academic labs that are interested in the biological effects of enzyme X almost always need a small scale med-chem effort just to make the tools to look at the enzyme.
It is one thing to have a med chem effort directed at developing the tools to help the biologists, it is another thing to try to develop things to help the patient.
4. mark on January 28, 2007 11:20 PM writes...
As an academic researcher and current recipient of your NIH (aka, tax) dollars, I'm inclined to second the notion of not burning through limited funding in direct pursuit of what the private sector is designed to do. (Although were I able to add formatting, the word 'direct' would be in italics, and perhaps underlined as well.)
And yet...
I'm curious to know what the actual academic track record is in this regard. Perhaps someone out there can attend this particular session of the Med Chem division at the Spring 2007 ACS National meeting, and report back:
"Drugs from Academia: Marketed Drugs Discovered in Academic Labs."
J. E. Macor, Discovery Chemistry, Bristol-Myers Squibb Pharmaceutic al Research Inst., Five Research Pkwy., Wallingford, CT 06492, (203) 677-7092
5. Canuck Chemist on January 28, 2007 11:23 PM writes...
Great remarks Derek. I'd like to see more good people make the transition from industry back to academia, because I think they can have some great insights into some of the unmet problems you mentioned related to developing medical treatments.
As a postdoc with involvement in a new "drug development� institute, I agree wholeheartedly with Milkshake's comments. Especially because the teamwork that is needed to develop a drug is just not going to happen between profs and researchers with diverse goals and research interests. That being said, I think that institutes which focus on bridging the gap between biology and chemistry can serve an important purpose. I think it's a more reasonable goal to discover and develop tool compounds (modulators of biological targets) for novel targets. The work by Schreiber, Schultz and others to provide compound libraries for biologists seems like a worthwhile cause. Even more important, I would say, is the continued research by academics into the isolation and synthesis of natural products and their analogs. This is an area which most big pharma cut back on when the combichem craze started. The work by Danishefsky into the synthesis of epothilone analogs stands out as some very nice work which led to important clinical results. I would also underline the innovative work of bioengineers to provide cheap syntheses of natural products (e.g. Keasling's work on the large scale biosynthesis of artemisinin), and also work by Clardy to make otherwise inaccessible natural products from expression systems using DNA isolated from soil microbes. The great value of these natural products is worth another discussion…
6. Steven Jens on January 28, 2007 11:52 PM writes...
Eugene, would your "national drug company" be substantially different than spending public funds on basic research at NIH and hundreds to thousands of research universities?
7. Joshua on January 29, 2007 9:21 AM writes...
Derek - though I certainly understand where you're coming from (and I've heard this same point-of-view from a number of people who work for pharmaceutical companies), I'd like to ask you who should be developing drugs for all those important, yet neglected, infectious diseases that are responsible for the deaths of millions of people in developing countries?
Don't get me wrong - I completely understand that drug companies are for-profit enterprises and that they have a responsibility to their shareholders to maximize profits. And the math is simple: earnings from erectile dysfunction drugs, chronic diseases, etc. >> earnings from new anti-malarials, TB drugs, other infectious diseases, etc.
I agree that academic groups might not be able to tackle this problem as efficiently/effectively as a drug company, but someone needs to do this (thank goodness for the TDR, the DNDI, and the NITD...)
If most pharmaceutical companies aren't willing/able to tackle these problems, why shouldn't academic groups give it a try?
8. JSinger on January 29, 2007 9:32 AM writes...
Modern drug discovery takes a lot of resources, from several rather widely separated fields...
What I've been urging, ever since I arrived in industry from (biology) academia and found that I didn't have the slightest idea how the drug discovery process worked, is education for basic researchers. Local, decentralized, one or two day seminars where university researchers listen to a series of short presentations from the different line functions.
Hopefully that will lead to scientific advances. (Maybe some smart grad student who really, really understands his system will have some bright idea about formulation!) But, if only out of intellectual curiosity, you'd think basic researchers would want to understand where their work goes, instead of just adding "...and may lead to a cure for cancer." at the end of every RO1 proposal.
9. S Silverstein on January 29, 2007 9:32 AM writes...
Another place where some academic thinking could come in very useful would be in attacking the important pharmaceutical processes that we don't understand: things like pharmacokinetics, oral availability, human versus animal toxicology, and (lots of) better disease models.
Another thing academics can do is to attack (critique?) the ideological/social assumptions in pharma that lead to suboptimal use of pharma's own resources, such as:
1. The HR disaster area - the belief that work is about "process" and "skillsets", not "ability and creativity", which translates to poor hiring and retention practices (a symptom is the automated screening of resumes on the basis of a far too granular 'skills grid', as opposed to what a person has done);
2. The habit of putting people without domain expertise into improper positions of authority, right up to CEO level;
3. The short-term focus on profit at the expense of long-term strategy;
4. The morale-killing effects of mass layoffs, which are certainly a sign of management failure both in the necessity for them arising, and in the execution despite the effects on overall morale;
5. The bumbling that goes on it IT (on the provider side, examples such as here).
In other words, the social aspects of the business. This is an area known as social informatics. This is not rocket science, nor biomedical science, but the effects of inattention to this area are quite serious.
As a former (downsized) pharma person, I have firsthand experience.
10. biff on January 29, 2007 9:56 AM writes...
Re. a "national drug company," a curious blend of politics and business has led a few places to push the idea of "national champions" - for example, the French with Sanofi-Aventis and the Germans with Bayer. The rest is left as an exercise for the reader.
11. MolecularGeek on January 29, 2007 10:48 AM writes...
I wholeheartedly agree that academia ought to concentrate on the research that makes drug discovery possible. Sadly, this may not be an option for most researchers. NIH is on a crusade for translational research, read "what you do ought to be clinically relevant in 5-7 years". It also sounds a lot like them trying to force academic labs to become the postulated USA National drug company above. This is just a bad fit. As has been noted, drug discovery is a cross-disciplinary process, and with some exceptions, PIs don't like to depend on external collaborations for their primary funding.
What worries me the most is that funding for basic research in biomedical science is drying up, even as the government scrambles to add dollars to the NIH budget. The NSF can't pick up the slack, especially when they have to avoid stepping on toes at NIH over what they fund, and DoE and NASA have very limited mandates as well. Academic labs may not discover many drugs, but they have provided much of the underlying knowledge that allows for target selection in industry. Who is going to pay for this now? As I have said before, big pharma is getting risk-averse, and I can't see Pfizer (pfor example) paying for teams of biologists to unravel the signaling pathways that control pre-natal bone development (again, as an example). There may be interesting results that come out of it, and I am sure that any of us can suggest ways that such a topic could be the basis for a drug discovery/development project, but in the absence of a clear economic incentive, I wouldn't bet on it. I hope that it won't come down to us only understanding the processes in the human body that are profitable to interfere with.
12. Dennis on January 29, 2007 11:03 AM writes...
I am an undergrad interested in organic synthesis. It seems to me that you're suggesting that most of the problems that should be tackled by academia are biological or biochemical in nature. Do you believe organic synthesis has any place in academia?
13. eugene on January 29, 2007 12:27 PM writes...
#6 (also, #10, #11) Steven, no it would be completely different. The government has a national aerospace company, so it could expand into the drug business. It would have a similar structure to an existing large entity (eg. Bayer), and would operate like an industrial entity. NIH is nothing similar. Too many disparate groups competing for funding on different projects. This company could also compete with the private sector for talent, and would rely on people from the private sector (or formerly from the private sector) to oversee it. This would be an even better arrangement than NASA. Think of Russia's national oil company. They behave as a private entity but act solely in the interest of the cronies in Moscow to the benefit of the country (or maybe just the cronies). I'm sure a real democracy can do better.
The government would essentially be negotiating with itself over drug prices, and although the company would probably be operating at a loss because of it, it would be worth it. Especially if the government figures out how to make a buck on insurance. Plus neglected diseases could be pursued when it is politically convenient (not economically convenient).
In any case, I just though I'd throw out the suggestion so that someone with a better knowledge of politics and business could shoot me down.
14. Jose on January 29, 2007 12:49 PM writes...
regarding your questions about marketed drugs from academia, there are only a few examples, as far as I know. Holton's taxol semi-synthesis, and Dennis Liotta's (Emory) anti-virals is about the sum total....
15. Anonymous on January 29, 2007 12:56 PM writes...
Let's not also forget the possibilities with all the charity funding becoming available. Thanks to the generosity of Mr. Gates and Mr. Buffett, it might be possible to fully fund more not-for-profit organizations (academic or otherwise) dedicated to discovering treatments to those illnesses which are difficult to profit from. I think it's a mistake to fund more targetted research at the expense of more basic studies (as the NIH is doing), but if we can find a way to fund both (e.g. by more private and public support), that would be great. What about pouring a fraction of all that useless pharma marketing money back into research?
16. Canuck Chemist on January 29, 2007 12:58 PM writes...
(Whoops, ignore the previous anonymous comment)
17. david on January 29, 2007 2:04 PM writes...
A national drug company. You mean like the Pentagon? Or Central Intelligence? Those are national, and they're monopolies which don't function very well in spite of considerable legal leeway. (And let's not forget the wonderful results brought by the folks who brought us Iraq II--all of which are striking endorsements for national anythings--not.)
As for academia, last time I looked, most department chairs had major problems in making a commitment for $500K to support a prized faculty member for a couple of years to get grants funded. Now you're asking them to wager $50-100 million on a drug which may never make it to market? I don't think faculties have either the patience or understanding to do discovery work, even though the process looks so straightforward to them. Also, the level of regulatory scrutiny associated with discovery and development would cause tremendous faculty reaction. All in all, if faculties think the process so easy, they should incorporate and show their stuff. I think they'll get discouraged at how hard it really is.
18. Al on January 29, 2007 2:57 PM writes...
A UK Perspective
It is perhaps telling that not one person has yet commented on the role that the academic community has in educating the bright young people entering the industry. [Surely undergraduate and graduate education is at least half the task of a university, or doesn't that count for anything anymore?]
In my personal experience, the teaching of medicinal chemistry is at best patchy (BSc in Chemistry with Medicinal Chemistry), with little to no input from experienced industry hands in the lecture theatre teaching the theory and practise of what it is that goes on in drug discovery labs around the world.
Lookie here for the med chem offering from Aberdeen University (UK) a top rated department for undergraduate teaching. Looks to me like not one specifically tailored component for an industry bench med chemist. Rubbish!
Perhaps industry should be looking to do what it can in bringing the challenges and excitement of drug discovery into the classrooms of universities and colleges across the land. You quite often hear of apparent skills shortages with companies looking to recruit into the junior ranks.......so why the disconnect?
In my experience it is equally true that at present most universities have little to no interest in actually teaching med chem (at least what an industry person would call med chem anyway!). A while back I was half-pondering a return to academia, but was lacking in formal teaching experience. What I did was to offer to teach some classes/workshops in med chem to give the students an informal (ie unassessed) introdcution to medicinal chemistry. Not one of the 40 or so institutions I wrote to was in the least interested in the offer, even though I was offering to do it at marginal cost (travel+expenses).
So to Prof. California I say, establish yourself a solid teaching program. Invite in outside lecturers from industry. Visit industry labs and ask about what they do, about what they feel their BS/MS new hires generally lack in terms of knowledge. Build from that. Pester your new found contacts in industry for projects.
It is a two-way street, but at the moment the parties are standing at opposite ends, pretending not to care what the other half is doing.....
19. CA prof on January 29, 2007 4:19 PM writes...
I'm happy to see that nobody is really promoting the idea that academics just need to keep producing kids with synthesis union cards for the methyl-ethyl-butyl-mill. However, this is still a big (usually unspoken) reason for sustaining the (usually big) labs that do that sort of vocational training.
As someone who watches the academic side of things, I can say that there are very, very few in this business who kid themselves about "doing everything". Nobody on an R01-style budget, or even a big NIH grant-budget, is trying to do lead discovery, animal tox, and human trials. However, many academics think they can do discovery better than risk-averse Big Pharma. One of the most pressing issues in that approach is "how far do we need to take a molecule before Pharma pays attention to us?" In vitro kinase inhibition? Cell culture model of angiogenesis? Animal model of angiogenesis? Animal model of cancer? You get the idea.
The "forgotten diseases" model is also an angle - usually for the more expensive enterprises.
Derek's wish list for academic contributions falls under what I would call "removing risk" from development. Predicting PK, oral availability, etc. might increase the yield of leads that become drugs b/c, presumably, Pharma would be able to better focus its resources on things that have a chance of showing efficacy. However, as far as I can tell, the academy has mostly given up on what Derek lists. You won't find many Pharmacology departments that actually do pharmacology any longer - at least not at the "top" schools. Don't even get me started on physiology.
I think academics have a better shot at removing risk by inventing new things - either new knowledge (how a signaling protein works), or new technologies that might help with target validation/credentialing or better disease models, etc.
I was interested in Post #5 from Canuck chemist. I, for one, don't put much faith in screening small molecules for perturbants of biology. Want a new drug? Show me safety and efficacy! Want a new biological probe? Show me specificity!!! I think the specificity question is a huge albatross for that business. Also, time will tell, but did Sam's group really add any value to the epothilone story? In other words, if Sam had not done that work, wouldn't Pharma and biotech have found the same variants? I would certainly hope so.
20. A-non-y-mous on January 29, 2007 5:39 PM writes...
The question isn't really what should academics do, but rather, what should NIH do. Most (not all) academic researchers are at the mercy of the steel fisted and currently penny pinching NIH for their RO1 support. They write the grants that they feel NIH will fund so that they can support not only their students, but themselves as well. Successful RO1 awards display micro-to-milimolar compounds, and are full of catchy buzz words and catch phrases: "potential drug", "cure cancer", "revolutionize the drug industry", "previously unknown therapeutic target", ad nauseam. The NIH likes these words. They want to feel important too. They want to be a part of the solution, not part of the problem.
I would like the NIH to get back to funding more basic science. Remember, academic research is about learning; training new grad students how to think and approach problems. With that background, then they can go into industry and apply their skills to real world problems.
If academic research is to change, it has to start at the source: NIH.
But really, besides dwelling over where the money would be better spent, are NIH funded med chem projects really that big of a deal? Probably not. So ignore the above and remember the below.
Hi, I'm cantankerous, and these are my $0.02.
21. CA prof on January 29, 2007 6:58 PM writes...
Just a quick comment about post #18 and the idea that academics are not teaching enough of this stuff. In short, we try, but it's a bit like having priests lecture about marriage counselling - what the heck do we know?!?!
I've always thought that this sort of science was better suited to the physicial/med student model. Teach them the basics and then send them into the "wards" to learn the real way. As for a degree that reads "Medicinal Chemistry", I think Derek has posted his opinion of the value of that in previous posts, and I completely agree. I don't think modern drug discovery can be "taught", but I sure as heck hope it can be learned.
I don't think anyone has to spend much time at all trying to convince young people that drug discovery is interesting or an important part of all of our futures.
22. mark on January 29, 2007 7:38 PM writes...
I believe that part of the difficulty in confidently assigning academia or research institutes more direct credit in drug discovery (as opposed to occasionally receiving, say, a Best Supporting Actor Award in Target Validation) is that the provenance of certain drugs is murky, or sometimes just forgotten.
Two examples worth citing: AZT and taxol. The former was first synthesized at the Michigan Cancer Center (although towards a different indication than for which it is now approved). The latter, which you mentioned, involved nonprofit activity that predated Holton. Taxol emerged from natural product extract screening at the NCI, followed by compound isolation at Research Triangle Institute, and subsequent mechanism of action determination at Albert Einstein College of Medicine. Fast-forward through clinical trials to eventual licensing by pharma, and the rest is med chem textbook fodder.
These two cases are perhaps dated and certainly in the minority, but my gambling instinct tells me that we haven't seen the last of convoluted discovery stories of important therapeutics that originate in nonprofit laboratories.
23. Dr. Know on January 29, 2007 9:08 PM writes...
There's alot of scratching head here but the reality is that automated factories producing trillions of compounds (along with slave wage factories in the Ukraine and India) is where all this is heading. Only about a 1000 Americans earn a PhD in chemistry each year and yet the US fails to provide a lucrative living for even these few dedicated individuals. I'd suggest you spend your time ORGANIZING instead of discussing inspired flights of fancy. You can only save the 'field' when there are people in it to save. Right now you're being outsourced (particulary via those academic labs) and buried in a sea of new arrivals. How can you expect salaries to rise with a tidle wave of people coming in and factories moving to China?
There's no reason a chemist should make any more than the minimum wage. Market forces will push you there if you allow them to. In a few years a BS or PhD in chemistry will be one of the most worthless pieces of paper you can own.
Form a union and fight back if you care. Or do you expect one of those cut to the bone MBA's to look out for you?
(a comment from an ex-chemist)
24. The Strider on January 30, 2007 6:12 AM writes...
Academic researchers can and do discover promising targets or molecules with therapeutic potential. Such discoveries can result from a through study of a pathway, a plant, a complex, etc. that is very natural for an academic lab. These discoveries can be very promising but someone still needs to bridge the gap between the in-vitro indications and the in-vivo validation that are needed for Pharma to show interest. I don't think that there is a good solution right now. It is also important in these cases to take care of IP issues because commercial companies need to know that the target/molecule they are working on is protected.
25. molecularArchitect on January 31, 2007 12:26 AM writes...
This is a good thread and addresses several problems in the whole pharma/biotech enterprise.
Re #9: All excellent points. I see no solution as long as the top people in the industry continue to come from the ranks of our top B-schools. MBAs seem to be incapable of thinking past short-term profits, of understanding the complexity and difficulty of drug discovery and development, or having any concern for the people (i.e. disposable human resources) responsible for the technical advances enabling their grossly inflated salaries.
Re #20: I've spent my career in the industry but have written many grants and served on NCI grant review committees. The political pressue on NIH, NSF, etc to produce "measurable" results is intense. Funding real basic research is difficult in this environment. A great example is that, under pressure from lobbying groups, Congress appropriated a huge amount of money for breast cancer research. This money did not go to NCI though. It is administered by the Department of Defense, who wanted nothing to do with the program. NIH/NCI/NSF are pawns in the congressional/lobbyist power games.
Adding to this is the desire of universities and professors to cash in on intellectual property. This has caused fundamental changes in the academic research environment. Changes which have not necessarily been to the benefit of science. The current dispute between Holton and Florida State University shows how big money has corrupted academia. There are many other examples. When I was a graduate student, the members of my department's three synthesis labs interacted closely, we even had periodic joint group meetings. I've been told that this is no longer the case at many top schools. Students are discouraged from interacting with members of "competing" research groups. Exactly the training that one does not need to suceed in industry.
Re #18: I've said before that schools don't make good med chemists but the schools alone are not at fault. The technical management of industry is populated largely by an "elite" that comes from just a handful of renowned academic research labs. Their hiring is biased towards those of similar hard-core synthesis training, preferably from the same handful of academic labs. Graduates of more broadly focused medicinal chemistry programs are often seen (by these managers) as generalists who are not experts in synthesis. This managers prefer to hire synthesis experts and teach them med chem. This being the case, there is little incentive to change the academic model. What is absurd about this reality is that the chemistry we do in industry is rarely cutting-edge. The creativity is in the design of the molecule not its synthesis (except in process, that's where the real synthesis experts are). Med Chemists use the same basic reactions over and over again.
This incestuous hiring also leads to industrial med chem groups where everyone has been trained to approach problems in the same way. Is it any wonder that so many pipelines are dry?
In summary, current academic practices are inadequate to train the talent needed for success. All efforts to reform academia to address this will fail unless industry changes its own approach to staffing. We will all need to wear coats in hell when this happens!
26. milkshake on January 31, 2007 1:40 AM writes...
I a problem with hiring hot graduates fresh from the best groups is that they tend to have big ego - which is a good thing with a bright young guy, to make his mark in the world - but not necessarily the best situation for the lab. You cannot have too many hungry egos and arrogant self-confident guys who don't know much about developing a drug but like to commadeer others. You need to have a mix of people that besides being competent are reasonably content in their position and don't see it just as a stepping stone.
There was a strange atmosphere at Agouron whn I was interviewing there, just before the Pfizer merger - and I think over-saturation with the best and brightest was a part of it...
27. MTK on January 31, 2007 6:24 PM writes...
A US national drug company? You've gotta be kidding me. There are areas where government is useful and essential. Competing with the private sector for the discovery and development of consumer products (which is essentially what drugs are)ain't one of them. If there is money to be made, the private sector is nearly always better. If the 20th century taught us anything it's that Adam Smith kicked Karl Marx's behind. Seriously, is there one government agency anywhere in the world that is better than the private sector in putting out a product? Airbus may be about as close as it comes and a) they're only government subsidized and b) they're really hurting right now.
This is what will happen if a "National Drug Company" is formed. You'll have biology research based in Congressman A's district, chemistry based in Congressman B's, DMPK in Congressman C's, Senator Byrd will make sure that there are 300 IT jobs in West Virginia. You get the point. It would be a complete waste of our tax dollars.
Now I understand that there areas such as developing nation diseases which will never get worked on by the private sector, so what do we do then? Assuming it's in the national interest to solve some of Africa's health issues (and I do), then the government should issue a massive prize, something like $10 billion, for a malaria vaccine, and let the private sector work its magic.
28. eugene on January 31, 2007 8:10 PM writes...
I think it's just very reflexive to say that the government cannot do better than the private sector everywhere. In countries other than the USA, this is simply not the case.
The USSR aerospace industry for example, performed very well when it was still the USSR. A little caveat, was that the aerospace industry was the only one where competition was allowed. Basically, there were several government sanctioned airplane manufacturers competing with each other. It created an unbelievable amount of innovation and quality products.
How about the insurance companies in Canada? The British Columbia insurance company is getting competition only recently, and is doing fairly well still. Being the only insurance company for a while (opposite to my first example), allowed the company to collect data on where most of the crashes happened in road accidents. The ten most dangerous intersections were improved to make them safer every year. This would not happen in the US unless competitors decided to get together and share data (and it eventually did happen after enough American companies became cognizant of the Canadian example and decided it would save them money).
Why have one national drug company? Have several. And give the 10 billion prize to the one that manages to find the malaria vaccine first.
29. Sohbet on December 5, 2008 4:28 PM writes...
I think it's just very reflexive to say that the government cannot do better than the private sector everywhere. In countries other than the USA, this is simply not the case.
30. Sohbet Odaları on July 26, 2009 1:47 PM writes...
I think it's just very reflexive to say that the government
31. Sohbet Odaları on July 26, 2009 1:49 PM writes...
32. Sohbet Odaları on July 26, 2009 1:49 PM writes...
33. Andy on July 26, 2009 3:34 PM writes...
Was this the chorus? :)
34. Bored on July 27, 2009 9:08 AM writes...
Government can do some things well. Our military, throughout its history is a good example of government doing a good job. Our space program, for the most part, has been a good example as well. But Government can't solve all problems, or even most problems. Individuals do that. The more we rely on Government, the less incentive any of us have to do anything.
Since the last election, a lot of Americans were
riding a wave of hope based on rhetoric. That ship has sailed.
35. Shirleen Richart on July 20, 2012 2:25 AM writes...
These days of austerity as well as relative stress and anxiety about getting debt, many people balk against the idea of utilizing a credit card in order to make acquisition of merchandise or even pay for any occasion, preferring, instead to rely on this tried plus trusted procedure for making settlement - cash. However, if you possess cash available to make the purchase 100 %, then, paradoxically, that's the best time just to be able to use the credit cards for several motives.
Email Address:
Remember Me?
About Us |
Advertise |
Contact Us |
Privacy Policy |
Terms of Use
© Copyright 2006 Corante. All rights reserved. ()


text:
Application Information
Scholarship Overview
This scholarship is for students who have lost a parent or sibling to suicide during their high school careers. To qualify for this scholarship, applicants must live in the Fox River Valley area in Illinois and demonstrate financial need and academic ability.
How easy is it to apply?
Not too bad
This scholarship's application process may have items such as essays that could take a couple hours.
How much competition is there?
Relatively little!
This scholarship has a relatively low number of applicants.
Financial Need: Is this you?
Financial need will be considered.
Class Year: Is this you?
- High school senior
Home State: Is this you?
- Illinois
Location: Is this you?
- Fox River Valley
Other Qualifications: Is this you?
- Friend / Family Member Committed Suicide


text:
VIDEO: Help Is A Phone Call Away
September 2, 2013 3:58 PM
Living at home and remaining independent is possible for these hospice patients thanks to the 24-7 support, clinical expertise and ability to dispatch a member of the hospice team. It's called Telecare®.
(Provided by VITAS Innovative Hospice Care, serving patients in Ft. Worth and Dallas. Go to VITAS.com/Texas.)


text:
Sign up for all the important updates and exclusive, limited-time offers, or select which newsletters you'd like to receive. You can update your subscriptions at any time.
Hear about the hottest songs and artists right now
Save up to 80% on the best dining, activities and events in your area
Get the latest 102.5 events, contests, and promotions
Already signed up? Manage your subscriptions.


text:
Creative Arts
Creative Writing
Write Your Life as Comedy
Whether you're writing a memoir, a screenplay, a stand-up set or a grocery list, the ability to amuse yourself and others is one of the best life skills you can acquire. Come have fun learning the tricks of comedy writing, playing silly writing games, and making your classmates laugh. This class is great for stand-up comics who need lots of material, and just as wonderful for writers and people who just need to let go laughing. Students, who choose to, will have the opportunity to perform their material (either as stand-up or story-telling) on stage at the end of the class. This class is held at the downtown LCC Campus.
Writing for Children
Join author and writing mentor Steve Alcorn and discover what you need to know to write for children. If you're a beginning writer, this course will help you transform your book idea into a finished product that could potentially land in the hands of an editor or agent. And if you're already a successful writer, this course will help you explore new opportunities and markets for your work.
You'll explore the changing world of children's literature and understand the various formats, including picture books, chapter books, middle grade or young adult novels. You'll get insights from publishing professionals to gain a better understanding of the needs of today's market. You'll receive valuable tips about creating your manuscript, and even practice writing a query letter to submit to a publisher. By the time you finish this course, you'll have all the tools and resources you'll need to begin navigating the world of children's publishing and to continue growing as a writer for children.
Mystery Writing
What makes a mystery? If you consider the books you've read most recently, you may be surprised to discover that many--if not all--are mysteries. From Dan Brown to Dennis Lehane, mysteries are hot items on today's best-seller lists.
This course will teach you the techniques you need to know if you want to become a best-selling mystery author.
Mystery Writing begins by introducing the four story types and then explains how they relate to mysteries. It then reveals the three-act story structure, which is any story's key to success. Next, it shows you how to propel the action forward to a climax, followed by a catharsis in which your readers feel the release of tension that accompanies a great finish.
The difference between story and plot is one of the most important distinctions in fiction writing--and one that many professional authors don't fully understand. But you will have mastered it by the end of this course. You'll also get a chance to experiment with viewpoints and see which one works best for your mystery. And you'll write a complete scene from your story and learn the internal structure that makes every scene feel right.
Finally, you'll delve into the special techniques that apply to mysteries, including crime scene description, MacGuffins, and the use of red herrings to misdirect your readers and create suspense. Examples from real mystery novels will show these techniques in action. Then, following each lesson, you'll get to practice on your own story. And when you have questions or insights to share, you can join your instructor and classmates in a dynamic, interactive discussion area.
This information-packed online course combines the best advice of many writing professionals, tempered with the instructor's own experiences as a mystery writer. Follow the guidelines taught in this course, and you'll be well on your way to writing a successful mystery of your very own!
View and Register for courses.
For more information contact Continuing Education at (541) 463-6100.


text:
Clean Water Is A Basic Right, Right?
That's what I thought. Check this out.
From the plastic production to the ocean in which so many of these bottles end up, this inspiring documentary trails the path of the bottled water industry and the communities which were the unwitting chips on the table. A powerful portrait of the lives affected by the bottled water industry, this revelatory film features those caught at the intersection of big business and the public's right to water.
The award-winning documentary Tapped recently embarked on an eco-aggressive 30-day/30-city cross-country tour to get Americans "Off the Bottle." Kicked off on World Water Day (March 22nd) Tapped's Producer Sarah Olson and Director Stephanie Soechtig collected pledges from people to reduce their bottled water use and traded empty plastic water bottles for reusable stainless steel bottles.
Director Stephanie Soechtig says, "1,500 bottles of water end up in landfills every second—that's 30 million bottles of water a day! We wanted to show people just how much waste is generated by bottled water—so if that means we have to drive city to city to get the point across than that's what we'll do!"
My husband, who is very logical (totally the opposite of me, the creative ), calculated we toss enough disposable water bottles to, lined end to end, circle the equator every few days. Less than 20% are recycled. That's just insane.
My son and I had the pleasure of meeting Stephanie and Sarah when they were in Chicago and they were kind enough to donate bottles to any kid in my son's third grade class whose family signed the pledge. So far, more than half have already signed!
Purchase the DVD and Tapped will donate 10% to a water charity. Then loan it to friends, co-workers, neighbors, family to help spread the word: Water is a right.
The movie can also be downloaded from AMAZON or ITunes.
McReview. I watched this movie with my 3rd grade son and he finally comprehends bottled water's negative impact—from the moment the water is pumped from the ground to the moment the empty bottle is disposed of. That it's not just about how the industry impacts the environment, but his future health and well-being. As a parent, I want to protect him. I don't want him to have to fight for drinking water and, ultimately, his—and his children's—survival. Isn't life challenging enough already? I urge you to watch this film with your family and then share it with as many others as you can.
Disclaimer: I am not a professional film reviewer.
Update: The UN recently declared clean water a basic human right. The U.S. abstained from voting (still trying to figure out why).
Incorrect source, offensive, or found a typo? Email us (please put title in subject bar of email so we'll be able to fix). Or do you want to write for Elephant?
{Waylon H. Lewis C Enterprises 2015: Use Rights in perpetuity. Ownership remains with author.}
4 Responses to "Clean Water Is A Basic Right, Right?"
Excellent! More people need to know as so much false data about "bottle water" being better. Some might be but how do you know. One popular brand boast 7.8 pH. I tested a bottle and it was 6.5-7.0 no higher. So even the "good bottle water" may not be good from day to day.
Eco-Cycle's got a campaign to avoid purchasing bottled water… includes a video for "The Story of Bottled Water," a video by Annie Leonard, who also created "The Story of Stuff." http://www.ecocycle.org/ecobuzz
Here's another article on the subject:
[…] There are many children's books and even documentaries you can watch together as a family. Tapped is an amazing film my son watched with us when he was 8. It unveiled the underbelly of the bottled […]
[…] help inspire drinking from the tap, you'll get a free SIGG reusable water bottle when you purchase $100 or more from myEARTH360.com. […]


text:
Constitution and By-Laws
Please click on each of the Articles to read.
|Article I
|Article II
|Article III
|Article IV
Article ISection 1.1 Nomenclature
The organization shall be known as the African American Faculty and Staff Association (AAFSA).
Section 1.2 Organizational Purpose
AAFSA seeks to establish a mechanism through which African Americans are fully recognized as contributing members of the University of Texas at Arlington and the community at large. The organization will accomplish this objective by advocacy and support for issues deemed important by AAFSA.
Section 1.3 Membership
Membership shall be open to all faculty and staff interested in professional development of staff /faculty and retention of students at UTA. Annual dues shall be twenty dollars.
Section 1.4 Goals
Through its presence and visibility, the African American Faculty and Staff Association (AAFSA) shall:
a. To provide advice and support to African American faculty, staff and constituents.
b. To sponsor mentoring opportunities for membership, etc.
c. To assist and advise on issues related to the advancement of African American faculty, staff and students.
d. To provide a forum for research and professional development.
e. To develop partnerships with other University organizations.


text:
Pooh's Hunny Pots Party Game
These Pooh-inspired honey pots are perfect for keeping craft supplies close at hand. Let preschoolers personalize theirs to make these bee-utiful keepsakes.
To start, paint the pot inside and outside with a base coat of white acrylic paint. Let dry.
Pull off a length of masking tape long enough to fit around the rim of the pot.
Cut a wavy line down the center of the tape and secure the tape around the outside rim of the pot. This will be a stencil for the dripping honey.
Now paint the inside of the pot yellow, and the outside of the pot in your child's favorite color. Terra cotta is porous, so you might need to apply a few coats to fully cover the pot. Let paint dry between coats. Let kids mix their colors in seal and lock bags. Squirt a few primary colors into a bag, seal it, and let kids squish the bag to blend. This is a great way to teach about primary colors, and color mixing.
Once the paint on the outside of the pot is dry, remove the masking tape and paint the remaining white area yellow, like honey.
To decorate your pots with thumbprint bees, help kids to press their thumbs into a yellow stamp pad. Dot the thumbprint "bees" onto the pots. Let the ink dry. Embellish the bees with black marker and Googly eyes.
To decorate your pots with flowers and butterflies, use cotton tipped swabs to dot on flowers. Butterflies are sideways hearts.
Use a black marker to write a message on your pot.
Use red tape to seal the edges of the carton and cover imperfections. Use red tape to cover the unsharpened pencil -- this will be the handle of the toolbox.
After decorating, seal pots with acrylic sealer. This will keep paint from peeling and will give pots a finished gloss.
For a fun twist, turn your pots into a color matching game! At the same time that you paint your pots, paint the wooden hearts and circle game chips to match. Let kids embellish the chips with thumbprint bees. Put your bees into a bag and let kids pull them out and sort them into their corresponding honey pots. Younger kids will love sorting and matching their colors. Challenge older kids to a speed round -- use a timer to see how quickly they can get all of their bees into their matching pots! Note: Painted pots are no longer suitable for plants or outdoor use.


text:
La Perla Perfume
By La Perla for Women
La Perla Perfume by La Perla, Launched by the design house of la perla in 1987, la perla is classified as a refined, woody, arid fragrance . This feminine scent possesses a blend of gentle cedar and moss, classic and dry. It is recommended for evening wear. All products are original, authentic name brands. We do not sell knockoffs or imitations. ... Read More
- Radiance
- Raffinee
- Rajasthan
- Ralph
- Ralph Cool
- Ralph Hot
- Ralph Lauren
- Ralph Lauren Blue
- Ralph Lauren Love
- Ralph Lauren Style
- Ralph Rocks
- Ralph Wild
- Rampage
- Rance
- Rance Soaps
- Raphael
- Rappelle Toi
- Rapture
- Rare Essentials
- Raven
- Real Patchouly
- Realities
- Realities (new)
- Realm
- Realm Fragrances
- Realtree
- Reb'l Fleur
- Rebel
- Rebelde
- Rebelle
- Red
- Red 2
- Red Delicious
- Red Delicious Charmingly Delicious
- Red Door
- Red Door Aura
- Red Door Revealed
- Red Door Shimmer
- Red Door Velvet
- Red Jeans
- Red Pearl
- Red Petal
- Red Sunset
- Reem Acra
- Reese Witherspoon
- Reflets D'eau
- Regency Cosmetics
- Regines
- Remember Me
- Remy
- Remy Latour
- Remy Marquis
- Renato Balestra
- Rene Lezard
- Repetto
- Replay
- Replay Your Fragrance
- Replique
- Republic Of Women
- Republica
- Reve
- Reve D'escapade
- Reve D'or
- Reve De Roses
- Reve De Weil
- Reve Elixir
- Reve Opulent
- Reveal
- Reveal Calvin Klein
- Reveal The Passion
- Reverence
- Reverie
- Rêverie Au Jardin
- Revillon
- Revlon
- Reyane
- Reyane Black
- Reyane Ii Mysterious
- Reyane Tradition
- Reyane White
- Ricci Club
- Ricci Ricci
- Ricci Ricci Dancing Ribbon
- Rice Flower And Shea
- Rifat Ozbek
- Rihanna
- Rihanna Rogue
- Rihanna Rogue Love
- Rio Glow
- Rio Rita
- Rive Gauche
- Riverside Drive
- Robert Beaulieu
- Robert Isabell
- Robert Piguet
- Robert Piguet Blossom
- Robert Piguet Chai
- Robert Piguet Jeunesse
- Roberto Cavalli
- Roberto Cavalli Acqua
- Roberto Cavalli Exotica
- Roberto Cavalli Nero Assoluto
- Roberto Cavalli New
- Roberto Cavalli Paradiso
- Roberto Verino
- Roberto Verino Gold
- Roberto Vizzari
- Rocco Barocco Black Jeans
- Rocco Barocco Gold Jeans
- Rocco Barocco Mouse
- Rocco Barocco Silver Jeans
- Roccobarocco
- Roccobarocco Souvenir D'italic
- Roccobarocco Tre
- Rochas
- Rock Me
- Rock Me! Summer Of Love
- Rock Princess
- Rock'n Dreams
- Rock'n Rose
- Rock'n Rose Couture
- Rock'n Rose Pret-a-porter
- Rocker Femme Fantasy
- Rockford
- Rockies
- Rococo Rouge
- Rodier
- Rodier Eau Legere
- Roger & Gallet
- Roger & Gallet Almond Blossom
- Roger & Gallet Bambou
- Roger & Gallet Bois D'orange
- Roger & Gallet Bouquet Imperial
- Roger & Gallet Cedrat Citron
- Roger & Gallet Fleur De Figuier
- Roger & Gallet Ginger
- Roger & Gallet The Vert Green Tea
- Roger & Gallet Vetyver
- Roma
- Romance
- Romance Always Yours
- Romance Silver
- Romance Summer
- Romance Summer Blossom
- Romane
- Romantic Story
- Romantina
- Romea D'Ameor
- Romeo Di Romeo Gigli
- Romeo Gigli
- Romeo Gigli 2003
- Romeo Gigli Profumi
- Romero Britto
- Roots
- Roots Spirit
- Rosa Di Filare
- Rosa Eau Legere
- Rosa Tous
- Rosabotanica
- Rosalinda
- Rosamor
- Rose
- Rose 4 Reines
- Rose Absolue
- Rose Absolute Secrets D'essences
- Rose Anonyme
- Rose Bourbon
- Rose D'amour
- Rose D'ete
- Rose D'ete De Rosine
- Rose De Courreges
- Rose Glamour
- Rose Infernale
- Rose Leger
- Rose Muskissime
- Rose Noire
- Rose Noire Absolue
- Rose Noire's Secret
- Rose Opulente
- Rose Oud
- Rose Perfection
- Rose Secrete
- Rose Splendide
- Rose The One
- Roseberry De Rosine
- Roses De Chloe
- Rouge
- Rouge Nocturne
- Rousse
- Route Mandarine
- Roxy
- Roxy Love
- Royal Bain De Caron Champagne
- Royal Delight
- Royal Doulton
- Royal English Daisy
- Royal Marina Rubis
- Royal Muska
- Royal Oud
- Royal Pavillon
- Royal Revolution
- Royal Rose Aoud
- Royal Screw
- Royal Secret
- Royal Secret Ii
- Royalissime
- Ruby Lips
- Rue 37
- Rue La Boetie
- Ruffles
- Rumba
- Rumba Passion
- Rumeur
- Rumeur 2 Rose
- Rupture
- Rykiel Woman Hot!
- Rykiel Woman Not For Men!
2.7 oz Eau De Toilette Spray (New Packaging)
Item #517759
In Stock & Ready to Ship!
$ 33.75Add To Cart
2.7 oz Eau De Parfum Spray (New Packaging)
Item #497046
In Stock & Ready to Ship!
$ 36.00Add To Cart
Free Shipping
This product has 20 Out of Stock items |
2.7 oz Eau De Parfum Spray (New Packaging Tester)
Item #501344
0.04 oz Vial EDT (sample)
Item #500358
0.04 oz Vial EDP (sample)
Item #524982
1.7 oz Eau De Parfum Spray (unboxed)
Item #453481
3.4 oz Eau De Parfum Spray (Tester)
Item #479565
3.4 oz Eau De Toilette Spray (Tester)
Item #483700
2.7 oz Eau De Parfum Spray (New Packaging -unboxed)
Item #516612
1.7 oz Eau De Parfum Spray (New Packaging - unboxed)
Item #502893
1.7 oz Eau De Toilette Spray
Item #417948
1.7 oz Eau De Parfum Spray (New Packaging)
Item #417947
3.4 oz Eau De Parfum (unboxed)
Item #448962
3.4 oz Eau De Toilette Spray
Item #417945
3.4 oz Eau De Parfum Spray
Item #417946
6.7 oz Shower Gel
Item #436948
6.6 oz Body Lotion
Item #417943
6.6 oz Body Cream
Item #417942
Customers Who Bought This Item Also Bought
About La Perla
History and background of La Perla. In 1954 Ada Masotti created in Bologna that corselry laboratory which later, under the leadership of her son Alberto Masotti, would become La Perla Group, a leading concern in the field of corsetry and swimwear fashion. Love for details and the art of dressmaking, together with an in-depth knowledge of the female body are just some of the "chromosomes" of La Perla Group. Read more about La Perla
More La Perla fragrancesfor Women: La Perla J'aime La Nuit , La Perla In Rosa , La Perla J'aime Les Fleurs , La Perla J'aime , La Perla Divina , more
for Men: La Perla Touch ,
See all La Perla products
Customer Comments
Best price on the net! My merchandise was received well wrapped in bubble wrap. Definetly would do business with FragranceX.com!
J. Cobb (Frisco, TX)
REVIEW SNAPSHOT®by PowerReviews
- Great smell (98)
- Draws compliments (89)
- Long-lasting (73)
- Great value (66)
- Sexy (57)
- Doesn't hold (11)
- Too expensive (5)
Best Uses
- Anytime (60)
- Signature fragrance (58)
- Daily use (51)
- Evening (40)
- Special occasions (32)
- Reviewer Profile:
- Classic style (82), Adventurous style (25), Natural style (16), Natural (4)
- Fragrance Type:
- Woody/earthy (56), Oriental/spicy (41), Floral (39), Citrus/fruity (19), Fresh/aquatic (18)
Most Liked Positive Review
A classic that everyone asks about...
I heard of this fragrance from a few women before but I was only reminded of it when I was browsing this site. Thanks to the other reviews that I read, I decided to...Read complete review
I heard of this fragrance from a few women before but I was only reminded of it when I was browsing this site. Thanks to the other reviews that I read, I decided to give it a try... I am SO glad that I did. This is my new signature scent, and believe me, so many woman are now asking me what fragrance I'm wearing because it really draws compliments. I only wish there were other products in the line that I could purchase so that I could layer the scent. I tend to need to reapply it to keep the topnote going. Other than wanting to go swimming in it, I absolutely LOVE La Perla. You won't be disappointed! Thanks FragranceX for the opportunity!
Most Liked Negative Review
Not like it used to be
I have used La Perla edp for many years and have noticed in recent times that it is not as strong as it used to be. You could apply in the morning and you...Read complete review
I have used La Perla edp for many years and have noticed in recent times that it is not as strong as it used to be. You could apply in the morning and you could still smell it at the end of the day. Now have to refresh at least 3 or 4 times during the day and the impace of this perfume has gone. Shame it used to be wonderful.
Reviewed by 127 customers
Sort by
Displaying reviews 1-5
Previous | Next »
- Tester Smells Awful
Best Uses
Comments about La Perla Perfume:
This tester had obviously been around for a long time and it smells nothing like La Perla.
Best Uses
Comments about La Perla Perfume:
The old La Perla was beautiful even up until 2 years ago but this bottle was so bad I didn't even give it away I put it in the garbage. Perhaps it was off I don't know.
- Draws Compliments
- Great Smell
- Sensual
- Sexy
Best Uses
- Anytime
- Evening Use
Comments about La Perla Perfume:
I find it very difficult to fault La Perla. It is not given enough credit and in a way that's great! Then the supplier would be out of stock and everyone would be wearing it!! If you like the sensual woody tones that are not too overpowering this perfume is for you. It is subtle yet fragrant and draws lots of compliments. I love wearing the perfume, I use it up too quickly, it definitely trumps all my other fragrances. 10/10.
- Fragrance Type:
- Herbal, Oriental/Spicy, Powdery, Woody/Earthy
- Not Overpowering
Best Uses
- Anytime
Comments about La Perla Perfume:
I use tis every day. Morning and evening and it is my signature perfume.
- Fragrance Type:
- Fresh/Aquatic, Woody/Earthy
- Draws Compliments
- Great Smell
- Not Overpowering
- Sensual
Best Uses
- Anytime
- Signature Fragrance
Comments about La Perla Perfume:
This is the perfume for me as no money else I know wears it. So often I would wear a perfume and then a friend would wear the same.
Only downside is la Perla have changed the shape of the bottle and it is harder to handle. Needs two hands which is hard for people with arthritis. I would so love the old bottle back.
- Fragrance Type:
- Floral, Fresh/Aquatic
Displaying reviews 1-5
Previous | Next »


text:
Consulting position based out of our New York City office, reporting to Creative Director. Entails work across several time zones, so flexible work hours will sometimes be required.
BrainPOP, a global leader in online animated educational resources, seeks an excellent User Experience Architect/Designer with a solid background in data-driven web-based applications for kids. You will work on an educational platform used by school administrators, teachers, and elementary and middle school students.
Develop Flash front-end for various database-driven applications
Develop (in conjunction with designers) original educational games and features
Update and maintain a host of existing Flash applications, working in conjunction with another Flash developer
Design engaging interaction models for core functionality of the platform
Construct elegant, innovative application pages based on UI guidelines to ensure pages are standards compliant, universally accessible, and cross-browser compatible
Evaluate and improve upon existing page and interface designs, while creating templates for new pages and interfaces
Present recommendations on functionality, navigation, scalability, user accounts and moderation/storage of user generated content
Update developers and creative team on current user interface best practices and emerging technologies
Identify needs, and translate key concepts into information architecture
Rapidly create static and dynamic prototypes for a web-browser based platform
Minimum three years in front-end/UI design role for web applications
Experience building information architecture, wire-frames, screen designs, templates, data flow optimization and diagrams, sitemaps, logical menu flow, usage patterns, content strategy, and use-case scenarios
Comfort developing multi-level user group designs
Experience completing full project cycles, from concept to deployment, including strategy, architecture, design, implementation, debugging, and support
Experience working on social media applications, e-learning platforms, learning management systems, content management systems, web-based/mobile educational products, or virtual worlds/gaming environments for kids not required, but a huge plus
Strong graphic design and UI sense
Familiarity with common design, image processing, production, and web 2.0 tools
Ability to hand code in HTML, CSS is a plus.
Excellent problem-solving, documentation, and English skills.
Ability to manage multiple projects simultaneously
To apply for this job, send a brief cover letter, resume, and links to your online portfolio or sample websites reflecting your work to firstname.lastname@example.com. Please add your full name to the email's subject. No phone calls.All qualified applicants will receive consideration for employment without regard to age, race, creed, color, national origin, ancestry, marital status, affectional or sexual orientation, gender identity or expression, disability, nationality or sex.
Back to Job Listings


text:
Me and Earl and the Dying Girl
Grudge Match
The Wolf of Wall Street
Date Night
The Ghost Writer
Night at the Museum: Battle of the...
The Air I Breathe
All Jon Bernthal photos
All Jon Bernthal films
Movies.com, the ultimate source for everything movies, is your destination for new movie trailers, reviews, photos, times, tickets + more! Stay in the know with the latest movie news and cast interviews at Movies.com.
Copyright © 2015 FANDANGO MOVIES.


text:
We are looking for high energy self-starters, with an ability to think &work independently, who will make a meaningful contribution to the work &mandate of the WSIB. You will have the opportunity to serve the public in this role, which involves travel throughout the province of Ontario. These permanent opportunities will interest those who have demonstrated sound judgement with excellent oral &written communications skills, who can build effective relationships &relate to people both inside &outside the organization.What can I expect to do in this role?• Plan & coordinate components of an investigation independently or with other Senior Investigators. Develop an action plan for commencing an investigation which can encompass four categories; Employers, Workers, Service Providers & Suppliers,& Internal Investigations.• Conduct confidential investigations in an efficient & timely manner. Review information/evidence to determine the scope & order in which to commence an investigative action plan. Propose & substantiate reasons for surveillance activity when required.• Conduct interviews & obtain statements from witnesses & cautioned statements from accused individuals.• Prepare and execute Search Warrant(s). Maintain continuity of exhibits. Prepare exhibit reports, detention orders and returns to the Justice of the Peace. • Analyze evidence and other information to determine the best course of action such as the laying of charge(s). Prepare and present reports containing investigative results to assist in decision making.• Prepare and deliver First Appearance Packages and Full Disclosure court briefs. Prepare draft resolution documents to assist Senior Prosecutor as required. Prepare and serve summonses, and other legal documents.• Assist in coordinating court proceedings. • Developing and maintaining strong co-operative relationships with law enforcement agencies and government institutions.How do I qualify?Knowledge and Skills• University completion at an undergraduate level or equivalent law enforcement educational background is required.• Knowledge and/or experience in Fraud Related Investigations or a Legal background sufficient to demonstrate the use of expert principles and theories at an innovative level where formulation of original concepts or approaches to work is required.• Strong judgement skills to analyze and evaluate the situation at hand • Knowledge of: law and court procedures as it relates to fraud and regulatory offences and the provisions of the Provincial Offences Act and the Criminal Code of Canada.• Investigative and interviewing techniques; and the execution of Search Warrants and the protection of evidence. • The ability to multi-task and be responsible for managing complex and confidential investigations, which may involve a project team approach. • Knowledge of computer systems and associated software such as MS Office (Word & Excel), Outlook and databases. • Knowledge of basic accounting practices and principles to analyze financial documents. • Knowledge of the Charter of Rights, Freedom of Information and Protection of Privacy Act, Canada Evidence Act, Ontario Evidence Act, Workplace Safety and Insurance Act, the Criminal Code of Canada, the Provincial Offences Act and other relevant legislation. • Influential skills requiring sensitivity, diplomacy and tact. Writing skills to prepare comprehensive documents including investigative reports, Information(s) to obtain a Search Warrant and court briefs. Oral skills to present complex and/or sensitive information to individuals or groups. .• Ability and willingness to travel throughout the Province of Ontario or elsewhere, providing their own vehicle, as a condition of employment.Note:As a precondition of employment, the Workplace Safety and Insurance Board will require prospective candidates to undergo a criminal record check prior to or at anytime following hire.Note:To apply to this position, kindly email your resume and cover letter in a single MS Word or PDF document and indicate in the subject line: "Senior Investigator, Last Name, followed by First Name"
Additional information:
Job advertisements for positions that have been designated bilingual will be provided in both English and French on the website. Positions that are not designated bilingual are not translated and are displayed in English only on both the English and French versions of the website.
Les annonces d'emploi pour les postes désignés bilingues sont publiées en anglais et en français sur le site Web. Les annonces pour les postes qui ne sont pas désignés bilingues ne sont pas traduites et elles figurent en anglais seulement, tant dans la version française que dans la version anglaise du site.
The Ontario Public Service is an inclusive employer.
Accommodation is available under the Ontario Human Rights Code.
Note: The only website where you can apply on-line for positions with the Ontario Public Service is http://www.gojobs.gov.on.ca
This site is maintained by the Government of Ontario
Terms of Use
Queen's Printer for Ontario, 2007
Last Modified:


text:
Entries tagged with: Vaccines
Primavera Sound have announced their 2013 lineup, set to go down on May 22-26 in Barcelona, Spain. The announcement came via an animated video and artists performing include Phoenix, The Postal Service, Blur, Nick Cave & the Bad Seeds, My Bloody Valentine, Tame Impala, Wu-Tang Clan, Dead Can Dance, Grizzly Bear, The Knife, and loads more. Current lineup is below along with the flyer and video...
Alt-J at Mercury Lounge in May (more by Dominick Mastrangelo)
Big day for award nominations. The Oscars announced theirs this morning and the Brit Awards just wrapped up their ceremony for 2013 nominations, with Emeli Sandé grabbing four and Mumford & Sons and Alt-J each getting three. All three of those artists were nominated for British Album of the Year, a list that also included Paloma Faith and Plan B. If you don't know, The Brits are basically the UK's equivalent of the Grammys, though nominees are all British apart from a few "International" awards.
Jessie Ware, Muse, and Adele each got two nominations, and single-digit noms went to Bat for Lashes, The xx, Richard Hawley and The Vaccines.
Mumford & Sons have two nights at Barclays Center in February and Alt-J will swing though town in March.
The entire 2013 Brit Awards nominees list is below.
Continue reading "2013 Brit Award nominees announced (Emeli Sandé, Mumford and Alt-J lead the pack)"


text:
224 Superior Street
Victoria, BC, V8V 1T3
Email: firstname.lastname@example.com
A Special Date? A Special Birthday? Trying to make up or rekindle an old flame?
This special romance package is all you need to set the right mood for ... well, we'll leave the rest up to you.
Add this package to any two night stay for only $289 (a $330 value. You save $41).
Price is for 2 people.
Were historic ... and we like to be naughty.
This package includes:
* Chocolate truffles
* Champagne
* Roses
* A $100 gift certificate to one of our gourmet partners:
* A 30 minute carriage ride with Victoria Carriage Tours.
An additional night and/or a relaxing Dual Massage can be added if you wish. Please speak to Don for details.
When all is said and done,
more is said than done.
anniversary, a honeymoon, or a quiet weekend in the Jacuzzi.
We want your stay at
Albion Manor B and B Inn
to be the crowning touch to your visit to Victoria BC, Canada.
We'll do everything we can to ensure that it is!
Home • Rooms • Policies
About Us • Breakfast • Contact Us • Our Location• Blog
Packages • Contact Us
Activities • About Victoria BC • Getting To Victoria BC
Albion Manor Bed and Breakfast
224 Superior Street
Victoria, BC, V8V 1T3 Canada
Toll-free: (877) 389-0012
Local phone: (250) 389-0012
Web site: www.albionmanor.com
Email: firstname.lastname@example.com


text:
Retail Price List
View All Mike Balter Products
Search by Model Number
My favorite keyboard handle choice is: (please check one)
What do you like most about Mike Balter Mallets?
How can Mike Balter Mallets be Improved?
Is there another brand of mallets you use?
If yes, which brand and model?
What new products would you like to see from Mike Balter Mallets?
My percussion supplier is (name and address):
My main percussion instrument is: (please check one)
I am a: (please check all that apply)
I own and use Mike Balter: (please check all that apply)
Thank You for your time and filling-in our questionnaire.
Join Our E-NewsMailing List.
For Email Marketing you can trust
Where toBuy


text:
|Get 1 Year of unlimited Apress for $199
|Instant access to all available titles and new releases
Related Titles
- Full Description
PivotTables are powerful data analysis tools, yet most Excel users dont use them to their fullest potential. A Complete Guide to PivotTables: A Visual Approach shows you why PivotTables are so versatile for data analysis and how you can leverage PivotTables to rapidly spot trends and make fast business decisions on mountains of data.
A series of step-by-step tutorials and plenty of sample business data will help you get productive with PivotTables quickly and easily. Whereas most books only devote a small section to PivotTables, this book covers everything about this important Excel feature. With his tremendous experience writing about Office and Excel for power users, Paul Cornell will teach you plenty about PivotTables.
- Source Code/Downloads
- Errata
Please Login to submit errata.No errata are currently published


text:
Email updates, contests and more... are you IN?
Jim joined us this morning to hit us with the latest breaking stories in the world of sports. Donald Sterling is still fighting the NBA with the sale of his team, L.A. Clippers. Metallica is looking for a new job on ESPN since the retirement of Mariano Rivera. And what it's like to live next to LeBron James.
NOTE: This thread is moderated, comments will not post immediately.
Simply confirm your registered email address below and click "Reset Password." We will immediately email you a link back to the site where you can enter a new password for this account.
We've found your existing Link Insiders account. Please login below to complete the Facebook login process.
For more information and market availability: Contact Tony Garcia at 303.916.6333 or email email@example.com
Copyright© 2015 by Greater Media All Rights Reserved.


text:
Ambassador David H. Thorne Statement on the January 18 Death of Italian Alpino, Luca Sanna, in Bala Murghab
Afghanistan, January 18, 2011
I spent much of today in Herat and Kabul in the company of Italians helping bring stability to Afghanistan and its people. It was therefore especially tragic for me to learn of the death of another brave Italian Alpino, Luca Sanna, in today's incident in Bala Murghab.
On behalf of the American people and government, I extend my deepest sympathy to the family and loved ones of the soldier killed in today's incident. Our thoughts and prayers are also with his injured compatriot. I saw first hand today that their sacrifice, and Italian military and civilian dedication, are making an important difference in the lives of Afghans.


text: Harry Potter | IBDB: The official source for Broadway Information IBDB: The official source for Broadway Information Official Broadway League sites: - sites - broadway.org broadwayleague.com broadwayfanclub.com kidsnightonbroadway.com stagespecs.org tonyawards.com Quick Search For: In This Category: All Show People/Org. Theatre Season Harry Potter Performer Male Productions ProductionsDate of ProductionsThe Rose Maid[Musical, Operetta, Original] Performer: Harry Potter [Ensemble]Apr 22, 1912 - Sep 21, 1912Up and Down Broadway[Musical, Revue, Original] Performer: Harry Potter [Chorus]Jul 18, 1910 - Sep 17, 1910 Find out where Harry Potter and are credited together © 2001-2015, The Broadway League, All Rights Reserved. (Copyright and Disclaimer)


text: Photos: Honoring those who serve Share this story email Share this story «Previous 47 of 54 Photos Next » « » Veterans Day Thomas McGibney serves in a color guard during a Veterans Day ceremony on Monday, Nov. 11, 2013 in Montpelier, Vt. Across the nation, Americans are commemorating Veterans Day with parades, wreath-laying ceremonies, monument dedications and other events. McGibney is an Army veteran who served during the Vietnam war. (AP Photo/Toby Talbot)


text:
May 29, 2013
The Service And Learning Leadership Team (SALLT) Project at Trinity Lutheran College has released a new smartphone application designed to facilitate meaningful service projects and mission trips with youth. It is available as a free download for both iPhone and Android from www.sallt.org/store.
Features include:
In addition, a Leader's Toolkit section includes:
Mark Jackson and David Ellingson, professors of Children, Youth & Family Studies, created the app for the SALLT Project, which Trinity launched in 2004 with a Thrivent Financial for Lutherans grant to develop youth leadership through service learning. The ELCA Texas-Louisiana Gulf Coast Synod also contributed to the phone app project.
For more information about the SALLT Project, visit www.sallt.org.


text:
Air tanks & brackets
The Iveco range of replacement parts includes a comprehensive braking component range, including Air tanks & brackets. It includes a vast array of both fast moving Iveco parts and some that are harder to find outside of the franchised network.
All our Braking components and the Iveco range are suitable for the majority of UK models, including: Iveco EuroCargo, Stralis, EuroTrakker and EuroTech.
The vast majority of our Iveco Braking range is to Original Equipment (OE) standard and all parts come with a 12-month, unlimited mileage guarantee, so you can be confident of the quality of the parts we supply.
All available with the Imex promise of exceptional quality product and high stock availability, the comprehensive Iveco range allows customers to choose an alternative supplier outside of the dealer network and have access to the complete parts package at low prices.
For more information call Imex on Lo-Call: 0845 60 50 404 or landline: 01977 553936.
*All manufacturers names, numbers, symbols and descriptions are used for reference purposes only and do not imply that any Goods and/or Services or parts listed is the product of these manufacturers. Calls to Imex Lo-Call number are charged at local rate when calling from a BT landline. Charges from other networks or mobile phones may vary and maybe higher.


text:
National briefs: March 13
800 small dogs seized at trailer
TUCSON — About 800 small dogs, including Chihuahuas, terriers and Pomeranians, were seized from a triple-wide mobile home whose occupants were overwhelmed trying to care for the animals, authorities said Wednesday.
Pima County sheriff's deputies and animal welfare officials who removed the dogs also found 82 caged parrots in the home in a rural area northwest of Tucson.
"The home was definitely in very bad condition, urine and feces all over the home, in the kitchen and bedroom, with a very strong odor," Jenny Rose, a spokeswoman for the Humane Society of Southern Arizona, said. But, she said, the animals "were in pretty good shape."
The elderly owners, who have not been identified, were apparently overwhelmed but have cooperated with authorities, sheriff's Sgt. James Ogden said.
North Carolina
Man arrested in student's slaying
HILLSBOROUGH — Demario James Atwater, 21, who is charged with murdering the University of North Carolina student body president was arrested Wednesday as detectives hunted for a second suspect.
Police would not say which suspect they believe shot and killed Eve Carson, 22, of Athens, Ga., who was found a week ago lying on a street about a mile from campus. The biology and political science major had been shot several times.
Early ocean fishing for salmon ended
GRANTS PASS — Fisheries managers Wednesday canceled early season ocean fishing for chinook salmon off Oregon.
Eric Schindlr, supervising biologist for the Oregon Department of Fish and Wildlife in Newport, said fisheries managers meeting in Sacramento did not want to risk catching so many fish in March and April that they would have to cut any chance of fishing later in the year.
Oregon Salmon Commission member Mark Newell said fishermen figure they will be lucky to get any fishing in July and August, so they had not been expecting the March and April season set last year to hold up.
—From wire reports
Subscribe to the Ventura County Star
Need Help? Call us at 1-877-710-6182.
Monday-Friday: 6am-3pm / Saturday: 6:30am-10:30am / Sunday: 7am-11am


text:
Are you moving home?
Move It With Les of Nantwich has been established for 21 years.
Our experience and professional manner have resulted in a service that always leaves the customer satisfied.
We do all removals, including house removals and office relocations.
We also provide a bank courier service.
If you're moving home in Nantwich and want a local, reliable firm who care about the work they do, get in touch with us today.
Our house removal services include:
- House moves
- Office relocation
- Internal office moves
- Bank courier service
- Single items of furniture
- Pianos
- Packing is available
For a local removal company who always take care of your possessions in Nantwich call Move It With Les of Nantwich on 01270 626 836


text:
Table of Contents
Covers C++11
LESSON 1: Getting Started
A Brief History of C++
Programming a C++ Application
What's New in C++11
LESSON 2: The Anatomy of a C++ Program
Part of the Hello World Program
The Concept of Namespaces
Comments in C++ Code
Functions in C++
Basic Input Using std::cin and Output Using std::cout
LESSON 3: Using Variables, Declaring Constants
What Is a Variable?
Common Compiler-Supported C++ Variable Types
Determining the Size of a Variable Using sizeof
Using typedef to Substitute a Variable's Type
What Is a Constant?
Naming Variables and Constants
Keywords You Cannot Use as Variable or Constant Names
LESSON 4: Managing Arrays and Strings
What Is an Array?
Multidimensional Arrays
Dynamic Arrays
C-style Strings
C++ Strings: Using std::string
LESSON 5: Working with Expressions, Statements, and Operators
Compound Statements or Blocks
Using Operators
LESSON 6: Controlling Program Flow
Conditional Execution Using if … else
Getting Code to Execute in Loops
Modifying Loop Behavior Using continue and break
Programming Nested Loops
LESSON 7: Organizing Code with Functions
The Need for Functions
Using Functions to Work with Different Forms of Data
How Function Calls Are Handled by the Microprocessor
LESSON 8: Pointers and References Explained
What Is a Pointer?
Dynamic Memory Allocation
Common Programming Mistakes When Using Pointers
Pointer Programming Best-Practices
What Is a Reference?
LESSON 9: Classes and Objects
The Concept of Classes and Objects
Keywords public and private
Copy Constructor
Different Uses of Constructors and Destructor
this Pointer
sizeof() a Class
How struct Differs from class
Declaring a friend of a class
LESSON 10: Implementing Inheritance
Basics of Inheritance
Private Inheritance
Protected Inheritance
The Problem of Slicing
Multiple Inheritance
LESSON 11: Polymorphism
Basics of Polymorphism
Using virtual Inheritance to Solve the Diamond Problem
Virtual Copy Constructors?
LESSON 12: Operator Types and Operator Overloading
What Are Operators in C++?
Unary Operators
Binary Operators
Function Operator ()
Operators That Cannot Be Overloaded
LESSON 13: Casting Operators
The Need for Casting
Why C-Style Casts Are Not Popular with Some C++ Programmers
The C++ Casting Operators
Problems with the C++ Casting Operators
LESSON 14: An Introduction to Macros and Templates
The Preprocessor and the Compiler
Using #define Macros to Define Constants
Using #define To Write Macro Functions
An Introduction to Templates
LESSON 15: An Introduction to the Standard Template Library
STL Containers
STL Iterators
STL Algorithms
The Interaction Between Containers and Algorithms Using Iterators
STL String Classes
LESSON 16: The STL String Class
The Need for String Manipulation Classes
Working with the STL String Class
LESSON 17: STL Dynamic Array Classes
The Characteristics of std::vector
Typical Vector Operations
Understanding the Concepts of Size and Capacity
The STL deque Class
LESSON 18: STL list and forward_list
The Characteristics of a std::list
Basic list Operations
Reversing and Sorting Elements in a List
LESSON 19: STL Set Classes
An Introduction to STL Set Classes
Basic STL set and multiset Operations
Pros and Cons of Using STL set and multiset
LESSON 20: STL Map Classes
An Introduction to STL Map Classes
Basic std::map and std::multimap Operations
Supplying a Custom Sort Predicate
LESSON 21: Understanding Function Objects
The Concept of Function Objects and Predicates
Typical Applications of Function Objects
LESSON 22: C++11 Lambda Expressions
What Is a Lambda Expression?
How to Define a Lambda Expression
Lambda Expression for a Unary Function
Lambda Expression for a Unary Predicate
Lambda Expression with State via Capture Lists
The Generic Syntax of Lambda Expressions
Lambda Expression for a Binary Function
Lambda Expression for a Binary Predicate
LESSON 23: STL Algorithms
What Are STL Algorithms?
Classification of STL Algorithms
Usage of STL Algorithms
LESSON 24: Adaptive Containers: Stack and Queue
The Behavioral Characteristics of Stacks and Queues
Using the STL stack Class
Using the STL queue Class
Using the STL Priority Queue
LESSON 25: Working with Bit Flags Using STL
The bitset Class
Using std::bitset and Its Members
The vector
LESSON 26: Understanding Smart Pointers
What Are Smart Pointers?
How Are Smart Pointers Implemented?
Types of Smart Pointers
Popular Smart Pointer Libraries
LESSON 27: Using Streams for Input and Output
Concept of Streams
Important C++ Stream Classes and Objects
Using std::cout for Writing Formatted Data to Console
Using std::cin for Input
Using std::fstream for File Handling
Using std::stringstream for String Conversions
LESSON 28: Exception Handling
What Is an Exception?
What Causes Exceptions?
Implementing Exception Safety via try and catch
How Exception Handling Works
LESSON 29: Going Forward
What's Different in Today's Processors?
How to Better Use Multiple Cores
Writing Great C++ Code
Learning C++ Doesn't Stop Here!
A: Working with Numbers: Binary and Hexadecimal
B: C++ Keywords
C: Operator Precedence
D: Answers
E: ASCII Codes
Purchase Info ?
With CourseSmart eTextbooks and eResources, you save up to 60% off the price of new print textbooks, and can switch between studying online or offline to suit your needs.
Once you have purchased your eTextbooks and added them to your CourseSmart bookshelf, you can access them anytime, anywhere.
Sams Teach Yourself C++ in One Hour a Day, CourseSmart eTextbook
Format: Safari Book


text:
2006 Highlights
July 3, 2006
2006 NAMI Convention
Changing Minds, Changing Lives, Keeping the Promise
NAMI welcomed its members, friends, and scores of others whose lives have been affected by serious mental illness to the nation's capital from June 28 - July 2 for the 2006 NAMI Convention.
Attendees enjoyed four days packed with workshops, seminars, program tracks, exhibits, receptions and entertainment. From meeting face-to-face with some of America's top mental health researchers and physicians, to visiting with congressional representatives, to honoring the achievements of the NAMI movement over the past year, the opportunities for learning, networking, advocacy and celebration abounded.
Thank you to all the presenters, volunteers, staff, sponsors, and attendees who made this year's convention such a success. We look forward to seeing you next year for the 2007 NAMI Convention in San Diego, June 20 - 24.
Daily Highlights and Photos:
Related Resources:


text:
Candlewood Suites Watertown-Fort Drum
Candlewood Suites Watertown-Fort Drum
All-Suite Watertown Accommodations Feel Like Home
The Candlewood Suites® Leray - Watertown hotel invites you to settle in and feel at home in our extended stay, all-suite hotel. North of Watertown on Route 11, you'll find our property conveniently located across the street from Fort Drum and just four miles from I-81. We are also just 12 miles from Watertown International Airport (ART) and 20 miles from Lake Ontario.
Business travelers appreciate more than just our hotel's location while in Watertown, NY. They enjoy free wireless Internet access throughout the hotel, plus an on-site Business Center open 24 hours, so they can stop by when it fits their schedule.
Upstate New York is alive with exciting attractions, and you'll find plenty to explore in and around the hotel. Enjoy nearby Watertown attractions such as the Veterans Memorial Riverwalk along Black River and the historic Paddock Arcade. To the south, you'll find that great shopping abounds at Salmon Run Mall and to the north, majestic beauty awaits you in the Thousand Islands.
We know that extended stay travelers need a hotel that understands their unique needs. That's why we've made sure to provide everything you need to feel right at home. Stop by the Candlewood Cupboard for snacks at value prices or melt stress away in the 24-hour Fitness Center. We took care to ensure your comfort with our hotel's amenities. So while in Watertown, NY, we hope you'll "Consider Us Home".
Quick Info
- Check In: 3:00 PM
- Check Out: 11:00 AM
- Minimum Check-In Age: 21
- Late Check Out Available
- Parking: Free
- Print Fact Sheet
- Chat With Us
Important Update
- On-site Guest Self-Laundry Facilities
- Standard Wireless Internet service is free for all members
- On-site Fitness Center Available
- Outdoor Gazeebo Grill
It's hard to leave your best buddy at home when you're traveling for extended periods, so we provide a pet friendly experience. Restrictions and fees apply.
Whether you are booking suites for a family reunion or suites for your company's training needs, Candlewood Suites hotels can accommodate your group.
Workout whenever you want: Candlewood Gym always has an open door and lots of aerobic and cardio equipment to make it easier to stick to your exercise routine, no sweat.
At Candlewood Suites® hotels, we want you to experience comfort in every sense.
Getting Here
Guest Reviews
Overall Experience
Nice place to stay...
September 30, 2015
Great hotel. My only suggestion is... If you don't have kids traveling with you, get a room on the top floor. My only issue with the stay was the noise coming from the above room with kids running around...
Friendly staff
ByCindy v
September 30, 2015
This was for the most part a nice hotel. Friendly staff and nice room with kitchen and nice bathroom. The bed was extremely hard. The staff explained that there is usually a soft topper placed on the mattress. That would have made our stay much nicer, as with the hard mattress we did not sleep well. I would stay here again, as long as the bed was more comfortable with the topper.
Bed sheet should be changed from previous guest
ByDave Shanghai
September 30, 2015
Overall the hotel looked new and clean.
The only little issue was that our room's bed sheet was not changed (had someone's long hair).
Otherwise, the hotel was not bad. :)
Great Hotel
September 28, 2015
We were celebrating our 30th Anniversary and wanted the option to prepare most meals in our room and proximity to hiking trails. This hotel has shopping nearby, a great room and friendly staff. We totally enjoyed our stay and will return when we are back in the area.
The full size fridge and two burners plus microwave offered great options for cooking and we were able to borrow a toaster oven as well.
We loved the upstate NY options for hiking and sightseeing. The Watertown area also offered a good variety of shopping options.


text:
- Northern New York Newspapers
- Watertown
- Ogdensburg
- Massena-Potsdam
- Lowville
- Carthage
- Malone
- NNY Business
- NNY Living
- NNY Ads
The following students from Northern New York were named to the deans list for the spring semester at SUNY Potsdam. To receive deans list honors at SUNY Potsdam, students must receive a grade point average between 3.25 and 3.49.
@datebook city label underlined:Adams Center
Thea Durant, psychology
@datebook city label underlined:Alexandria Bay
Arial Bauer, theatre
Lauren Umstead, art studio
@datebook city label underlined:Beaver Falls
Nicole Hall, art studio
@datebook city label underlined:Bombay
Jaliza Burwell, English and creative writing
@datebook city label underlined:Brasher Falls
Alyssa Brand, art studio
@datebook city label underlined:Brushton
Rebecca Whitehill, childhood/early childhood education
@datebook city label underlined:Camden
Tyler Hill, English and creative writing
Kelsey Munz, music education
@datebook city label underlined:Canton
Allan Cox, sociology
Elizabeth Jent, criminal justice studies
Brenna Schaefer, English and creative writing
Clark Soulia, sociology
Tori Thomas, history
@datebook city label underlined:Carthage
Stephanie Hall, anthropology
Ernest Marilley, childhood/early childhood education
@datebook city label underlined:Chase Mills
Victoria Elia, childhood/early childhood education
@datebook city label underlined:Chaumont
Colleen Knapp, archaeological studies
David Siembida, politics
@datebook city label underlined:Clayton
Sara Orvis, politics
Anthony Pike, undeclared
@datebook city label underlined:Colton
Haley Billings, business administration
@datebook city label underlined:Dickinson Center
Danielle Fountain, mathematics
@datebook city label underlined:Edwards
Jerrica Jones, English literature
@datebook city label underlined:Evans Mills
George DeVita, business administration
Michael Porcello, undeclared
@datebook city label underlined:Fort Covington
Brittany Bigness, art studio
@datebook city label underlined:Gouverneur
Shawn McClure, geology
Khylee Rowe, mathematics
Morgan Ruel, business administration
Sarah Van Vleet, speech communication
Courtney Weldon, childhood/early childhood education
@datebook city label underlined:Hailesboro
Nichole Fuller, psychology
@datebook city label underlined:Hammond
Jessica Martin, biology
@datebook city label underlined:Hannawa Falls
Robert Hewey, business economics
@datebook city label underlined:Harrisville
Emily Dickinson, politics
Jeri Miller, art studio
@datebook city label underlined:Hermon
Rebekah Smith, Spanish
@datebook city label underlined:Hogansburg
Deneen Cole, biochemistry
Bianca Jacobs, Akwesasne, childhood/early childhood education
@datebook city label underlined:Lowville
Lauren Croniser, psychology
Heather Dunn, art studio
Morgan McGrath, childhood/early childhood education
Ashlee Rhone, childhood/early childhood education
Brandon Shettleton, business administration
@datebook city label underlined:Mannsville
Michael Lord, computer science
@datebook city label underlined:Martinsburg
Melinda Hoch, childhood/early childhood education
@datebook city label underlined:Massena
Michelle Block, business administration
Erin Casey, childhood/early childhood education
Michael Deshaies, politics
Joel Dsouza, business administration
Jie Faulkner, history
Marilyn Fernandes, biology
Amanda Gagne, psychology
Allison Holliday, childhood/early childhood education
Brenton Johnson, English writing
Stephen Smith, childhood/early childhood education
Diane Van Winkle, childhood/early childhood education
@datebook city label underlined:Moira
Robert Leabo, Spanish
Chenice Russell, biology
@datebook city label underlined:Natural Bridge
Tracy Markwick, undeclared
@datebook city label underlined:North Bangor
Allison Manning, literature/writing
North Lawrence
Kirsten Jandreau, psychology
@datebook city label underlined:Norwood
Alex Cotey, criminal justice
Kenneth LaDue, history
Jessica Sullivan, biochemistry
@datebook city label underlined:Ogdensburg
Genevieve Carroll, history
Kelly Fitchette, history
Emily Hunter, community health
Megan Johnson, psychology
Steven Morrow, history
Jordan Refici, history
Christopher Schembry, mathematics
Sarah Smith, biology
@datebook city label underlined:Parishville
Christepher Clark, biology
@datebook city label underlined:Potsdam
John Alleyne, art studio
Ryan Arno, community health
John Bresett, anthropology
Hannah Butterfield, art studio
Kassie Cross, childhood/early childhood education
Lisa Dashnaw, art studio
Laneise Goggans, dance
Abigail Hansen, English and creative writing
Erin Kinnally, environmental studies
Travis Labar, criminal justice studies
Kevin Lambert, history
Brandon Linhard, musical studies
Sarah McCann, business administration
Ryan Mousaw, criminal justice studies
Nadine Oakes, theatre
Shanior Robinson, community health
Amber Sharron, speech communication
Anand Thakur, biology
Jamison Wood, psychology
@datebook city label underlined:Pulaski
Logan Lewis, psychology
@datebook city label underlined:Rensselaer Falls
Nicholas Hall, psychology
@datebook city label underlined:St. Regis Falls
Erika Parker, childhood/early childhood education
@datebook city label underlined:Star Lake
Julia Dowling, art studio
Alisa Hitchman, business administration
@datebook city label underlined:Tupper Lake
Natasha Brown, art studio
Kathleen Guiney, childhood/early childhood education
@datebook city label underlined:Waddington
Michael OBryan, mathematics
@datebook city label underlined:Watertown
Grace Chirico, undeclared
Rachel Desormo, childhood/early childhood education
Kayla Maine, English literature
Elisabeth Penree, biology
Abel Tavarez, criminal justice studies
West Stockholm
Abigail Scott, undeclared
@datebook city label underlined:Winthrop
Molly McCuin, childhood/early childhood education
Danielle Smith, childhood/early childhood education
Ashley Thayer, community health
Thousands of readers like you have made Northern New York Newspapers the number one ranked website* for local news and sports coverage in the north country.
You can continue on to this article in a few seconds, or you can visit one of our websites:


text:
Your cart is empty!
Water, Glycerin, Sodium Lauroyl Isethionate, Stearic Acid, Sodium Laureth Sulfate, Cocamidopropyl Betaine, Lauric Acid, Tallow Acid, Sodium Isethionate, Fragrance, Sodium Chloride, DMDM Hydantoin, Disodium EDTA, Methylisothiazolinone, Iodopropynyl Butylcarbamate.
How to use: squeeze body wash onto a wet pouf or washcloth and work into a rich, creamy lather. Use daily for best results.
It makes my skin soft, this is an excellent body wash for sensitive skin. This is excellent wash solution with out any side effects.
It contain Essential Oils. This body wash is 100% Natural, and Pure Vegetable Soap. The smell is so nice and fresh. I have very sensitive skin and this product works great for my sensitive skin. I would highly recommend it.
This lavender body wash gives Luxurious cleaning experience and it helps to relax muscles, simulate circulation. My skin has brightened a little bit.
Old spice body wash has the classic, manly smell. It has great scent which lasts for long time. I would highly recommend it.
This shower gel keeps me refreshing and fresh all the time, its aroma is awesome and wonderful.I love the smell,lather and moisturizing power of this gel.