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Ed Ruscha's Hollywood Boulevard: 1973 and 2002
By Paul White in Video on Monday 25 November 2013
Ed Ruscha's work in both paintings and film are influenced by the vernacular of Southern California. In 1966, he published Every Building on the Sunset Strip, a book about capturing a continuous shot of a two and half mile section of the strip. In 1973, he likewise photographed the entire length of Hollywood Blvd. Here […]
Photos by Vienna's Stefan Fuertbauer
By Paul White in New Photography on Friday 22 November 2013
I love this photo series of Viennese Wurstel Diners by Stefan Fuertbauer. These diners have been operating in Vienna since the 1870s, and in a response to the invention of commercial fast food, now have this nostalgic 60's Americana-type appearance.
BMW have commissioned famous artists to decorate their cars since 1975
By Paul White in New Art on Thursday 21 November 2013
Since 1975 BMW have commissioned artists to create art pieces on and about their cars, from sports racers to road cars. Artists such as Warhol, Lichenstein, Rauschenberg, Koons, even Australia's Ken Done have done one. A great synthesis of art and machine.
Decotora: decorating trucks with lights in Japan
By Paul White in New Photography on Thursday 21 November 2013
Tatsuki Masaru's Decotora photo series puts the lens on the seriously cool decorated trucks of Japan. These are apparently a reflection of the individuality of the owner, with most of them looking like spaceships from another time.
This Must Be The Place: a short film series about 'home'
By Paul White in New Film on Wednesday 9 January 2013
Check out this series of short films considering the notion of 'home'. I particularly love Hill, about a guy who became the caretaker of a remaining part of the crumbling Packard car plant in Detroit. Also check out Prime, about a burger joint that has been in Manhattan since 1938 and has remained unchanged since the 60's – a true time capsule.
Mike Kelley's Mobile Homestead's project on display in 2013
By Paul White in New Art on Saturday 22 December 2012
A sad loss earlier this year, Mike Kelley was an artist who influenced a generation and helped bring attention to Los Angeles as a vital art capital. His Mobile Homestead's project – a recreation of his childhood home mounted on a trailer – was only part completed at the time of his death. The Museum […]
The Boneyard Projects
By Paul White in Video on Saturday 22 December 2012
I saw some of these works in progress some time ago at a plane junkyard full of US Military surplus in Tucson, Arizona. Here's the end product. Pretty cool. Indeed.
New drawings by Paul White
By Paul White in New Art on Friday 21 December 2012
I am interested in the abandoned and obsolete in relation to contemporary culture. My recent drawings focused on the modern detritus frozen within the deserts of California and Arizona. Here in the majestic and desolate landscapes, objects of mobility such as planes, cars and other vehicles lay motionless and frozen in time. This imagery is […]
Wall mounted reliefs by Ron van der Ende
By Paul White in New Art on Friday 21 December 2012
Ron van der Ende uses salvaged and reclaimed timber to create wall mounted reliefs of the stuff of our everyday, or at least the everyday we have left behind: classic cars, cassette tapes, planes, houses, stereo systems, spaceships and more. This is inventive and clever work.
Led Zeppelin reunion performance in 2007
By Paul White in Video on Tuesday 18 December 2012
In 2007, the three surviving members of Led Zeppelin reunited for a one off performance, joined on drums by the original drummer's son – a young boy at the time of his father's death, which ended the band in 1980. Recently released as Celebration Day, this document captures of rock 'n' roll at it's finest. […]
Chris Burden's impressive kinetic sculpture
By Paul White in New Art on Tuesday 18 December 2012
This has been around a while, but is still one of the best things I have seen in a long time. Ok, I was right into hot wheels cars as a kid, but one must be impressed by this kinetic sculpture.


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Warning issued after men collapse taking drugs in Poole
Posted: February 11, 2013|
Police have issued an urgent warning after two Dorset men collapsed while taking an illegal drug called Thai Valium.
The pair fell unconscious and were rushed to Poole General Hospital at 6pm yesterday.
Detectives fear other people could take the potentially harmful substance.
One of the men, aged 41, remains sedated and is in a stable condition, while the other, 28, came to but was kept in overnight to be monitored.
Officers were called by South West Ambulance Service paramedics who were treating the men in Ashley Cross, Parkstone.
Detective Inspector Stewart Dipple said: "We cannot confirm at this stage if it is the controlled drug that has made the two men unwell, or if it was the quantity of tablets that were taken that caused them to fall ill.
"Our primary concern is to prevent other people potentially falling ill from taking the same drugs.
"The drug is described as a blue capsule of Thai Valium and is believed to come in blister packs of 10.
"It is not believed to be a prescribed drug or treatment, but rather an illegally supplied controlled drug.
"It is vital that any members of the public who purchased a similar drug do not to take them, and to keep them safe from others.
"They should be safely deposited at a police station, a hospital or medical facility, or a drug clinic."
Anyone with information about the supply of the tablets should contact Dorset Police on 101, quoting incident number 09:373, or phone Crimestoppers anonymously on 0800 555 111.

subset: commoncrawl


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This release is available in French.
Montreal, March 31, 2008 A team of Canadian and French researchers has identified a novel gene responsible for a significant fraction of ALS (sporadic amyotrophic lateral sclerosis) cases. ALS is commonly referred to as Lou Gehrigs disease, an incurable neuromuscular disorder that affects motor neurons and leads to paralysis and death within one to five years.
Published in the current online edition of Nature Genetics, the study on 200 human subjects with ALS was led by Doctors Guy Rouleau, Edor Kabashi, Paul Valdmanis of the Research Centre of the Centre hospitalier de l'Universit de Montral (CRCHUM). The team identified several genetic mutations in the TDP-43 gene by studying ALS patients from France and Quebec. They established TDP-43 as the gene responsible for up to five percent of the ALS patients.
The breakthrough is the result of teamwork with peers from the Waterloo and Laval universities in Canada and the Fdration des maladies du systme nerveux and the Institute of Biology (Unit de Neurologie Comportementale et Dgnrative) in France.
Building on past studies
In 1993, Dr. Rouleau and his team also helped identify superoxide dismutase as the gene that causes the disease in 10 to 20 percent of all familial cases of ALS. This cornerstone study led to development of several mouse and rat models of ALS that closely resemble the motor neuron disorder observed in ALS patients. These models have been very useful to study molecular and cellular mechanisms of disease and to test treatments for ALS.
TDP-43s normal function is to bind and splice RNA. Two years ago, a team from the University of Pennsylvania discovered TDP-43 in abnormal protein clumps, referred to as aggregates, in motor neurons of ALS patients. However, it was not certain whether TDP-43 causes motor neuron disease
|Contact: Nathalie Forgue
University of Montreal


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(click image to zoom-in)
|Author: Camille Pissarro
|Landscape, Painting, Oil on canvas, 54x65.3 cm
|Origin: France, 1900
The opportunity to view the city from his own windows, from a fairly spacious - and highly elevated - apartment, gave the painter great advantages. In 1898, he rented an apartment across from the Tuileries, with a superb view of the garden. Its windows looked out on the Bassin of the Tuileries, which in the present painting can be seen on the left. The round Bassin was a convenient reference point for taking spatial bearings. Next to it, the pathways and vendors' stalls in the gardens provide a geometrical foundation for the composition, giving structure to such paintings focused on shimmering atmospheric effects.
|Style: Impressionism
|Source of entry: formerly in the collection of Otto Krebs, Holzdorf
|Exibition: French Painting: 19th - 20th centuries
|Transferred from Germany after World War II
Pissarro - Wikipedia, the free encyclopedia
Camille Pissarro (Jovember 13, 1903) was a French Impressionist painter. His importance resides not only in his visual ...
|Camille Pissarro ~
The Artist
CAMILLE PISSARRO was born on Jthe Caribbean island of St. Thomas , Danish West Indies; to Abraham Gabriel Pissarro, of Sephardic (or ...
Pissarro, Camille
Brief overview on the life and work of the French Impressionist.
|Camille Pissarro
- Olga's Gallery
Comprehensive collection of the images of his works with biography and historical comments.
Unless otherwise noted, images this web site may be used for any purpose without prior permission.
Any material in the public domain found on this web site is not protected by copyright.
We make no representations or warranties with respect to ownership of copyrights in the images, and do not represent others who may claim to be authors or owners of copyright of any of the images, and make no warranties as to the quality of the images.
We shall not be responsible for any loss or expenses resulting from the use of the images, and you release and hold us harmless from all liability arising from such use.
We do not sell art prints, framed posters or reproductions. Ads are shown only to compensate the hosting expenses.


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I was so excited the other day when the package finally arrived at my doorstep. I had ordered it months ago and was expecting a really large box filled with the latest in fantastic gadgetry. I love gadgets probably like no other person but when they can give me a leg up on clinical management, this love escalates to a level that would render most folks to sedatives and restraints.
This was the deal that would help me solve so many of those pesky clinical details, like how I really measure this nebulous beast we face routinely. Needless to say, disappointment of a deep aching nature still echoes in the hollowness of my clinical conscience now that I realize I have been duped to the extreme by this unscrupulous company purporting to have the ultimate, most up to date measurement device for the quantification of the monster we and our patients must face daily.
I will not even begin to tell you how much I have yearned for such technology. Now that this technology has all disappeared in the quick vapor of seeing the thin envelope laying there on the mud stained door mat, indescribable anguish (no pain) has rendered me to a small corner in a dark room, rocking back and forth inconsolably in a fetal position, staring at the envelope.
Who is this beast we face daily? Why are we so afraid of it? Why can't we stand up for ourselves and fight it more effectively? These are complicated and tough questions that may never be fully answered but for the sake of a blog, let me try.
The beast, as you know, is pain. It is not that pain when you bend back your dominant thumbnail and break the nail halfway back with bleeding and all that stuff trying to get the hose attached to the tourniquet. (That really happened just this week. I could never come up with that analogy without some real-life experience.) Even though my mangled thumb could detect air mass movement in the adjacent state, this is not the type of pain I am referring to here.
I am talking about nociceptive chronic pain. While we are at it, let us talk about acute pain, especially postoperative pain. We know that if we do not adequately treat the acute, we can end up facing the much more daunting chronic pain.
There are many unfortunate patients out there who deal with this nasty unrelenting beast, because we are either being crippled by our inability to fight with all our weapons or we are not willing to. Maybe it is both. Many are scared by the Drug Enforcement Agency and other G-men threatening the practitioner for the over prescribing of medications, especially opioids.
Other practitioners just label a patient as an "abuser" or "drug seeker" if he or she asks for a specific painkiller or tells you the one you prescribed is not working. "Hey, Dude, that is some powerful stuff I gave you for pain," you want to yell back at the patient defensively.
What if the patient is simply one of those 10 percent of our population who does not manifest the cytochrome P450 2D6 enzyme, which metabolizes the prodrug (for example, codeine) into the active one (morphine)? Are these people then "seekers" or "abusers"? I think not. They are just DNA challenged. But how many of us can know that except by history taking and a belief that what the patient is telling you is true?
Well, there are now tools available that are going to become very popular in the near future to give us the ability to find the "CYP450 2D6er challenged." Then we can more appropriately prescribe for that patient. How? Just take a swab and wipe their buccal mucosa, mail it in and wait 48 hours. You will have your answer. In those fancy Ivory Towers of Academia, they call that Pharmacogenomics.
Now we need to discuss some facts about pain and outpatient surgery. I know you will find these facts titillating and perhaps even more enrapturing than finding out what is in my envelope.
Here are some salient excerpts from "Post-operative Pain Experience: Results from a National Survey Suggest Postoperative Pain Continues to be Undermanaged" by Apfelbaum and colleagues in the journal Anesthesia and Analgesia.1
• 73 million surgeries are performed annually
• 75 percent of patients experience pain after surgery (I hear some readers saying to themselves: "Well, that's a no brainer, Bob—I just cut her bone.")
• Approximately 70 percent of all surgeries in the U.S. now occur in an ambulatory setting.
• Negative clinical outcomes resulting from ineffective postoperative pain management include deep vein thrombosis, pulmonary embolism, coronary ischemia, myocardial infarction, pneumonia, poor wound healing, insomnia and demoralization.
Wow, now that is eye opening! Are you telling me that my surgical outcome can be jeopardized by poor pain management in the postoperative period?
Now here is a real axon kicker.
• It is estimated that the economic burden of treating chronic pain that develops from acute pain in a 30-year-old individual over a lifetime could be as much as $1 million.
Groups like the Joint Commission are taking this stuff seriously now and have been since 2001 when it mandated that pain management must be part of all patient care in hospitals in order for hospitals to maintain accreditation. What this means is that over the career of anyone who does even a modicum of surgery, there will be those unfortunate few who develop chronic nociceptive pain from acute surgical pain and they are going to cost us (the taxpayers) a few million bucks.
What can we do to prevent or preempt the possibility or probability of having one of our "acutes" becoming "chronic"? Here are a few of my suggestions.
1. Get to know the patient preoperatively and try to gain a sense of his or her psychology about pain.
2. Explain the procedure and tell patients all that you are going to do to help them avoid pain. Be empathetic and friendly. Researchers have proven that this lowers pain in the post-anesthesia care unit (PACU).1
3. Use preemptive blocks on every surgical procedure, even if it is just minor. I do this even with general anesthesia, which I use on almost all of my cases. Keep the stimulus from getting to the spinal cord.
4. Minimize dissection. When there is less tissue destruction, there is less pain. That is a fact.
5. Place long-lasting local anesthesia in the surgical sites at the end of the case.
6. Use some dexamethasone phosphate when possible and not contraindicated.
7. Have the anesthesiologist give them some ketorolac, which is proven to reduce postoperative demands in the PACU for opioids.1
8. Put the dressing on with just the right amount of compression. If patients call that night in pain, tell them to cut the bandage. What a difference this will make for some of them. Some patients just swell if they say their pain meds are not working—believe them. Change the prescription or increase the dose. Remember, they may be those patients who lack the enzyme.
9. Do not hesitate to give the patient a peripheral nerve block on post-op day one if he or she is having an inordinate amount of pain.
10. Take some time post-op if you have a patient with pain out of proportion to the procedure to see if there is something else going on (i.e. family problems, etc.). It would have been nice to know these things before going in to the surgery but then there is reality.
Most of the time, our patients come in telling us how much pain they were expecting and how they really did not have any. This is a good thing.
Now let us open that envelope and see what I just got from that company I was referring to earlier. It was just some sheets of paper for a visual analogue scale with sad to happy faces on it to measure pain. Yeah, that's right. Sheets of damn paper.
The fact is, with all our technology, we don't really have any way to objectively measure pain or quantify it. The mythical "pain-o-meter" just has not made it into production yet. When it does, I am getting one.
1. Apfelbaum JL, Chen C, Mehta SS, Gan TJ. Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg. 2003; 97(2):534-540.


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Enterprise Vault Exchange 2007 Journaling
I have what is probably a dumb question, but I have not been able to find an answer in the EV documentation (version 8.0.)
I have a client who is doing both user mailbox and journal archiving from Exchange 2007. This client has a total of 4 retention folders set up for users: 1 year, 3 years, 5 years, forever.
Is there a backend process (or some other process) which "links" or "ties" items archived from a user mailbox with items archived from the journal mailbox? So for example, when an item is archived into a mailbox archive and a journal archive, one year passes--the expiry process runs and deletes the message from the mailbox 1 year retention folder....does the same deletion occur to the copy of the message that was captured in the journal mailbox archive?
Or, does the journal mailbox archive have a completely separate retention policy that has no interaction with or relation to the policy applied to user mailbox archves?
Any insight will be GREATLY appreciated!
Thank you.
Comments 2 Comments • Jump to latest comment
Your Journal Mailbox will be a seperate archive that can have its own retention
Each user will have their own mailbox and have any retention you choose to give them as well
But from a metadata standpoint, EV treats an email that has been journaled and an email that has been archived in a users mailbox seperately. so if a user archives an email they received there will be two database entries (one for journal, one for the mailbox), the items will be indexed in the users mailbox and in the journal archive and files will be written.
When expiry comes along, say the user was set for a 1 year retention, expiry will delete that item, and remove the database entries and index entries , but the item in the journal will remain for however long you set the expiry up for.
It gets a little complicated with the OSIS sharing mechanism
So for instance say the user has a 5MB file, its in the mailbox and its in the journal.
The journal archives the item first, and you end up with say a 2MB file on disk (after compression)
The user then goes ahead and archives their item, EV then goes ahead and looks and see's that the item already exists, so it creates a small file that and a database entry, that points back to the 2MB file already stored.
Then after 1 year the users item expires, however the 2MB file will still remain on disk, because its being shared by the Journal user, and the journal user isn't done with it yet.
So things to watch out for are things like "hey we just expired 1TB worth of data!" however, you may not see 1TB or even close to that being reclaimed from disk, because journaling probably has all that data shared out anyway.
And lastly, if you wanted custom retentions in the journal based on senders, recipients, or contents
(i.e. MOM messages get set to 10 days, messages that have XLS files get retained for 7 years, and messages with ZIP files for 1 year etc) you would have to use DCS (Data Collection Services)
Well explained JW.
To add. What JW writes on the OSIS model is valid, provided that sharing is configured to share everything between the Journal and Mailbox archives.
If you have configured a seperate VSG/VS, (Vault Store Group/Vault Store), seperated out legal and mailarchiving, and share everything only in VSG or VS, then expiry will be seperated too.
The disadvantage is that the above mentioned 5MB file now gets stored twice, once in the Journal archive, and once in the users archive.
That in itself would not be a bad thing, but the above is a scenario I see in the EU.
Thank you, Gertjan, MCSE, MCITP,MCTS, SCS, STS
Company: www.t2.nl


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Leon Cullens' Blog
The IT sector lends itself very well for working as a freelancer. A lot of software developers actually have some freelancing experience. A lot of books and articles have been written about pleasing the client and delivering the right software at the right moment. Far less articles however have been written about the way clients should behave. That fact that clients pay our bills in the end doesn't mean we should tolerate their, sometimes, very rude behavior. This rant contains the subjects that, I think, are the most important. More...
Tags: agile, clients, rant
Name: Leon CullensCountry: The NetherlandsJob: Software Engineer / EntrepreneurStudied: Computer Science Main skills: Microsoft technology (Azure, ASP.NET MVC, Windows 8, C#, SQL Server, Entity Framework), software architecture (enterprise architecture, design patterns), Marketing, growth hacking, entrepreneurship
Get notified when a new post is published.


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Right now ... is 100% dis-functional.
Sincere apologies to the 225,000 people that have visited this site - around 300 per day. But orders are orders and the site must come offline.
Bavaria, reapidly becoming one of the most favourite beers in Malta is now available at the City!
For a limited period, a pint of "Bav" is available for JUST TWO EURO!
Tags: events
Events | General


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Document Number: 6389Head Start on College: Dual Enrollment Strategies in New England 2004-2005 - This report discusses: (1) the national picture of dual-enrollment policies, (2) systemic dual-enrollment approaches, (3) the New England landscape, (4) questions and observations regarding dual enrollment in New England, and (5) has a program guide that provides an overview of 19 dual-enrollment programs in New England. [Free registration required to access report.] (Nancy Hoffman and Amy Robins, Jobs for the Future, June 2005)...
Related IssuesHigh School
Postsecondary Success
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| Research Studies | Reports & Databases | State Legislation
| State Profiles | Projects & Institutes | Newsroom | Website User's Guide


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Follow along with Hemmings on Facebook and Twitter
While the Hemmings Blog is your go-to source for all things collector car, did you know that we're also on Facebook and Twitter? Pinterest, too, for that matter.
And we're pretty popular around the ol' social media watering hole – we're closing in on 3,000 Facebook followers and a whopping 7,000 Twitter followers. To celebrate, we're offering some neat goodies to the people who put us over the top with those mileposts – digital subscriptions to all the Hemmings titles.
And, better still, we're going to show our appreciation for all the folks who've been following us from Day One (or Day 17, or Day 432…) by giving away another pair of digital subscriptions to randomly selected longtime Facebook and Twitter followers, once we pass the mileposts.
So if you haven't followed us on Facebook (Facebook.com/HemmingsNews) or Twitter (Twitter.com/HemmingsNews) or Pinterest (Pinterest.com/HemmingsNews/), hop to! You'll get up-to-the-instant collector-car news and views, plus have a new place to discuss all your favorite parts of the car hobby.
Twelve Awesome Cars with Whitewall Tires
Coker Picks their favorites
4 Comments - Leave a Reply
4 Responses to "Follow along with Hemmings on Facebook and Twitter"
Didn't I just see that '49 Pontiac at a Hemmings Cruise-In ?
Kate….I've been a FB friend since nearly day one…always wondered who handled that for the Hemmings Nation. Keep up the great posts. And this olelongrooffan from the Hooniverse loves that lighted hood ornament on that ole Poncho.


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Nicole Parenteau is the Operations Manager at the Gorman Cardiovascular Research Group.
She has over 15 years of expertise in awards management and business administration. Her role in research management is fundamental to the success of the group.
She has degrees from the Art Institute of Philadelphia and Delaware Count Community College in computer design and animation.
Contact Information
Christen Dillard, BS (Pre-Veterinary Science from Delaware State University, 2009) has 3 years technician experience in laboratory animal research. She currently serves as Regulatory Manager and also a trained anesthesia veterinary technician for the Gorman Cardiovascular Research Group. Her duties include but are not limited to coordinating and maintaining animal research activities and supervising technicians. She is responsible for training, compliance and the maintenance of records for ULAR and all IACUC protocols. She is also involved in the preoperative, intra-operative and post operative care of the animals.
Jerry is a MRI Technologist certified by the American Registry of Radiologic Technologists (ARRT). He specializes in advanced Cardiac and Cardiovascular MRI utilizing custom developed sequences such as SPAMM, T1rho, PC, and 4D-flow.
He also assists in data analysis and technical writing, as well as pre- and post-operative animal care.
He has earned both his Bachelor's Degree and Master's Degree in the field of Radiological Technology from Jefferson University in Philadelphia, PA. He completed his clinical training at Robert Wood Johnson University Hospital; a level one trauma center.
Sabrina Leventhal, BS in pre-veterinary science and minor in Biology from the University of Delaware, and is currently a second year in the Masters of Laboratory Animal Science Program at Drexel University. In the past, she has worked in small animal clinics and has extensive research experience in Dairy Cattle Nutrition as well as Swine Behavior and Swine Veterinary Care. She will be involved in the preoperative, intra-operative, and post-operative care of the animal.


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With the land and industrial reform which it decides to undertake on 3 September 1945, Moscow intends to remove the basis of power for the major land owners and "Junkers" as well as the major industrialists in the Soviet Occupation Zone (SBZ) who are considered to have been the pillars of National Socialism.
Previously that summer, under the slogan "Junkers' lands in farmers' hands", began the dispossession without compensation of every estate larger than 100 hectares – a measure endorsed by all the re-established German parties in the SBZ. The dispossessed land is divided in parcels of ca. five hectares each and turned over to farm labourers, refugees, expellees and small farmers.


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Our Woman In
Another Romany exodus looms in wake of
Minority's leaders call for
more Romany representation on Czech police forces
DATELINE: February 25, 1998
-- OPAVA, north Moravia--As the country mourned the loss
of another Romany (Gypsy) to skinhead violence, Czech
officials braced for a mass exodus of Romanies again --
this time to the United States.
Roughly 300 people, including Czechs and Romanies,
gathered in this industrial city Feb. 21 for the funeral
of Helena Biharova, a 26-year-old Romany mother of four
who was allegedly beaten in Vrchlabi, eastern Bohemia, by
three skinheads six days earlier and thrown in the Labe
(Elbe) River, where she drowned.
Romany leaders say the attack has left about 200 families
eager to emigrate to the United States to escape racial
persecution here.
"I want to go to America because there is no racism
there," a young friend of the victim's family said
at the funeral, as the emotional crowd cried out
"death for death" and "God will kill them
for what they did."
The Czech Republic gained international notoriety last
year when hundreds of Romanies sought asylum in Canada
and Britain after two television documentaries portrayed
a good life for Romanies in both countries. The Canadian
authorities responded by reimposing visa requirements for
Czechs in October.
Jocelyn Greene, a press spokeswoman for the U.S. Embassy,
said there had not been any inquiries about asylum from
Romanies as of Feb. 23. "There would have to be a
lot of discussion. It's premature to say anything [about
their chances to receive asylum]," Greene said.
Romany leaders have asked Vladimir Mlynar, the Cabinet
minister in charge of minority affairs, to help
facilitate the emigrations. Daniel Radomersky, a deputy
minister in charge of minorities, said the government
will not help the Romanies emigrate because it is not a
realistic solution.
Three skinheads allegedly attacked Biharova around 11
p.m. Feb. 15 in the east Bohemian town to which she had
moved from Opava when she married. The attackers beat her
unconscious and then threw her into the river, police
Eliska Pilarova, 48, a journalist for Czech Radio who was
walking nearby, heard Biharova's cries for help. She
jumped in the river and tried to rescue the younger
woman. The victim told Pilarova what had happened as the
two women clung to a tree root. When the root broke, the
strong current dragged them under. Firefighters, brought
to the scene by Pilarova's husband, were able to rescue
only Pilarova. They continued to search for Biharova, and
found her body two days later.
Ondrej Gina, a Romany leader and member of the Council of
Nationalities, said Romany women have been especially
frightened by the attack.
"They can identify with the victim and felt it was
something that could happen to any one of them,"
Gina said, calling the attack cowardly and brutal.
"Men are angry, but the women are really
Biharova's family and friends were all reluctant to give
their names out of fear of further attacks.
"I am very afraid," one woman said, adding that
there have been other racial attacks in the region
recently, including the firebombing of a house in Krnov
in mid-January. "I won't send my children to school.
The main thing is the safety of the kids."
Police apprehended three suspects Feb. 16, each 23-24
years old, police said. The suspects, who reportedly
confessed to the attack, have been charged with murder
with a racial subtext, according to Milos Kriz, the chief
detective in east Bohemia.
However, police have yet to establish whether the
attackers were members of any skinhead groups. Kriz said
the case is still under investigation.
Pilarova will receive the Medal for Heroism from
President Vaclav Havel for her bravery in trying to save
Biharova. First lady Dagmar Havlova attended the funeral.
Many of Opava's non-Romany residents were also disturbed
by the attack. "I am afraid of the skinheads, not of
the Romanies," said Daniela Smutnova, a teacher who
attended the funeral.
Emil Scuka, director of the Romany Civic Initiative (ROI)
praised the police response to the attack, but he added
that ROI believes there should be more Romanies on the
country's police forces. "Its not just about
investigating racial crimes but about [their]
prevention," Scuka said.
Police spokeswoman Ivana Moosova, said there are only 20
Romanies with the country's 39,000-strong national force,
excluding the office of investigations. However, Moosova
said this number is misleading because many Romanies
register themselves as Czech nationals.
"I don't know how [more Romany officers] would
enable the police force to prevent racial attacks,"
she said. "But it would facilitate communication
with the Romany community. We are aware that there is a
need for better communication."
article first appeared in The Prague Post
February 25, 1998


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Book gift keeps on giving—December 10, 2010
Christmas is just around the corner. If you are still looking for the perfect gift for that special someone in your life, why not donate a book in their honor to the library. Each year the library has a great selection of books to choose from to donate in honor of or in memory of a loved one. This year the selection is vast and includes books for adults such as cookbooks, biographies, books on classic cars, and many more. There are also books for teens and young adults. We also have a good selection of picture books and non-fiction titles for children and even some beginning readers for the child in your life who is just discovering the joy of reading!
Not only is this a special gift for the honoree, but it is a special gift for the entire community. Each book donated to the library has a gift plate inside that tells who the book is in honor of and who donated it. This plate will serve as a reminder for years to come.
When you come in to donate a book, you have the option of being the first to check the item out or you can have it placed on hold for the honoree. Also it might even be fun to check out the book and wrap it up to be opened on Christmas Day. Hastings Public Library will also send out a card to the recipient of the book letting them know about the honor, or you can choose to pick up the card with the book so that it is a surprise.
The Christmas table books usually go fast, but don't worry if you do not see a book you would like to donate. You can make a donation to the library in honor of someone and specify what type of book you would like us to purchase.
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Levitra Pros And Cons
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Research Topics
Genomes and Genes
Gene Symbol: ADH4
Description: alcohol dehydrogenase 4 (class II), pi polypeptide
Alias: ADH-2, HEL-S-4, alcohol dehydrogenase 4, alcohol dehydrogenase class II pi chain, aldehyde reductase, epididymis secretory protein Li 4
Species: human
Top Publications
Research Grants
Scientific Experts
Detail Information
Publications151 found, 100 shown here
- ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studiesXingguang Luo
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Pharmacogenet Genomics 15:755-68. 2005We found strong associations between ADH4 gene variation and alcohol and drug dependence by the Hardy-Weinberg Disequilibrium (HWD) test and case-control association analysis in an initial study...
- Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysisStuart Macgregor
Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Hum Mol Genet 18:580-93. 2009..001) between alcohol consumption phenotypes and rs1693482 (ADH1C), rs1230165 (ADH5) and rs3762894 (ADH4)...
- ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studiesXingguang Luo
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
Neuropsychopharmacology 31:1085-95. 2006..The ADH4 gene, an important member of this family, is a functional and positional candidate for alcohol dependence...
- Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) samplePo Hsiu Kuo
Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Hospital 138, National Cheng Kung University, Sheng Li Road, Tainan 704, Taiwan
Alcohol Clin Exp Res 32:785-95. 2008..The present study examined evidence for the association of alcohol metabolism genes with AD in the Irish Affected Sib Pair Study of alcohol dependence...
- Human class II (pi) alcohol dehydrogenase has a redox-specific function in norepinephrine metabolismG Mårdh
Proc Natl Acad Sci U S A 83:8908-12. 1986..These features and the presence of pi ADH in human liver imply a physiological role for pi ADH in the degradation of circulating epinephrine and norepinephrine...
- Personality traits of agreeableness and extraversion are associated with ADH4 variationXingguang Luo
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Biol Psychiatry 61:599-608. 2007..Strong associations between ADH4 variation and SD have been reported...
- Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patientsCamila Guindalini
Human Genome Research Center, Department of Biology, Institute of Biosciences, University of Sao Paulo, Rua do Matao, Travessa 13, Number 106, Cidade Universitária CEP 05508 090, Sao Paulo SP, Brazil
Am J Psychiatry 162:1005-7. 2005The authors evaluated the association of three functional promoter polymorphisms of the ADH4 gene with alcohol dependence.
- Alcohol dehydrogenase polymorphisms influence alcohol-elimination rates in a male Jewish populationYehuda D Neumark
Braun School of Public Health and Community Medicine, Hebrew University of Jerusalem Hadassah, Jerusalem, Israel
Alcohol Clin Exp Res 28:10-4. 2004..The mechanism by which this allelic effect is mediated is not yet clearly understood. This study examined the effect of ADH2*2 on alcohol-elimination rates (AER) under experimental conditions...
- ADH single nucleotide polymorphism associations with alcohol metabolism in vivoAndrew J Birley
Genetic Epidemiology Unit, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
Hum Mol Genet 18:1533-42. 2009..SNPs were associated with the early stages of alcohol metabolism, with additional effects in the ADH1A, ADH1B and ADH4 regions...
- Cutaneous metabolism of glycol ethersDavid J Lockley
Skin Toxicology Group, Department of Environmental and Occupational Medicine, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
Arch Toxicol 79:160-8. 2005..However, ADH1, ADH3 and ADH4 predominate in rat skin, demonstrate different sensitivities to pyrazole, and are responsible for metabolising ..
- The intra- and extracellular proteome of Aspergillus niger growing on defined medium with xylose or maltose as carbon substrateXin Lu
Helmholtz Center for Infection Research, Inhoffenstr, Braunschweig, Germany
Microb Cell Fact 9:23. 2010..13 growing on defined medium with xylose or maltose as carbon substrate was carried out using 2-D gel electrophoresis/Maldi-ToF and nano-HPLC MS/MS...
- Regulation of aflatoxin B1-metabolizing aldehyde reductase and glutathione S-transferase by chemoprotectorsL I McLellan
Department of Clinical Biochemistry, University of Edinburgh, Royal Infirmary, U K
Biochem J 300:117-24. 1994..In addition, the effect of these drugs on the hepatic levels of an aldehyde reductase (AFB1-AR) that metabolizes the cytotoxic dialdehydic form of AFB1 has been studied as this enzyme also ..
- Molecular and metabolic retinoid pathways in the human ocular surfaceHachemi Nezzar
Universite d Auvergne, JE 2447, ARDEMO, France
Mol Vis 13:1641-50. 2007..The second objective was to demonstrate the presence of different enzymes transforming vitamin A to retinoic acid and the functionality of this metabolic pathway in the corneal epithelium...
- Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family membersTeruhiko Iino
Department of General Studies, Nihon University, Sakurajosui 3 25 40, Setagaya Ku, Tokyo 156 8550, Japan
Arch Biochem Biophys 416:180-7. 2003..by 3 alpha-hydroxysteroid dehydrogenase type 2, whereas 1(')-OXPH(4) was produced by aldose reductase, aldehyde reductase, and 20 alpha-hydroxysteroid dehydrogenase, and both 1(')-OXPH(4) and 2(')-OXPH(4) were detected as the ..
- Vitamin C. Biosynthesis, recycling and degradation in mammalsCarole L Linster
Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, Brussels, Belgium
FEBS J 274:1-22. 2007..Glucuronate is converted to l-gulonate by aldehyde reductase, an enzyme of the aldo-keto reductase superfamily...
- Inhibition of alcohol dehydrogenase after 2-propanol exposure in different geographic races of Drosophila mojavensis: lack of evidence for selection at the Adh-2 locusEdward Pfeiler
Centro de Investigacion en Alimentacion y Desarrollo, A C, Unidad Guaymas, Apartado Postal 284, Guaymas, Sonora 85480, Mexico
J Exp Zool B Mol Dev Evol 304:159-68. 2005..ADH-1 activity in female ovaries was inhibited less by 2-propanol than ADH-2. These results do not support the hypothesis that 2-propanol acts as a selective factor favoring the Adh-2F allele...
- Regulation of rat glutathione S-transferase A5 by cancer chemopreventive agents: mechanisms of inducible resistance to aflatoxin B1J D Hayes
Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
Chem Biol Interact 111:51-67. 1998..In addition to GSTA5, we have identified a novel aflatoxin-aldehyde reductase (AFAR) that is similarly induced by ethoxyquin...
- The role of liver alcohol dehydrogenase isoenzymes in the oxidation of glycolethers in male and female ratsL Aasmoe
Department of Clinical Pharmacology, University Hospital, University of Tromsø, Norway
Toxicol Appl Pharmacol 150:86-90. 1998..However, it was the same ADH isoenzyme (ADH-3) that oxidized the different glycolethers tested in both male and female rat livers, and the substrate specificity was 2-BE > 2-EE > 2-ME...
- Tracing the history of an enzyme polymorphism: the case of alcohol dehydrogenase-2 (Adh-2) of the olive fruit fly Bactrocera oleaeGeorge N Goulielmos
Department of Genetics, Agricultural University of Athens, Athens, Greece
Mol Biol Evol 20:293-306. 2003..The estimated age of the polymorphism is compatible with this hypothesis, but firmer support could be difficult to obtain...
- Resistance to aflatoxin B1 is associated with the expression of a novel aldo-keto reductase which has catalytic activity towards a cytotoxic aldehyde-containing metabolite of the toxinJ D Hayes
Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, United Kingdom
Cancer Res 53:3887-94. 1993..Therefore, this inducible enzyme has been designated aflatoxin B1-aldehyde reductase (AFB1-AR)...
- Impaired retinol utilization in Adh4 alcohol dehydrogenase mutant miceL Deltour
Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
Dev Genet 25:1-10. 1999b>Adh4, a member of the mouse alcohol dehydrogenase (ADH) gene family, encodes an enzyme that functions in vitro as a retinol dehydrogenase in the conversion of retinol to retinoic acid, an important developmental signaling molecule...
- Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant miceAndrei Molotkov
Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
J Biol Chem 277:13804-11. 2002The ability of class I alcohol dehydrogenase (ADH1) and class IV alcohol dehydrogenase (ADH4) to metabolize retinol to retinoic acid is supported by genetic studies in mice carrying Adh1 or Adh4 gene disruptions...
- ADH4-lacZ transgenic mouse reveals alcohol dehydrogenase localization in embryonic midbrain/hindbrain, otic vesicles, and mesencephalic, trigeminal, facial, and olfactory neural crestR J Haselbeck
Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
Alcohol Clin Exp Res 22:1607-13. 1998..Herein, we have used transgenic mice to examine the mouse gene encoding class IV ADH (ADH4), an enzyme that is weakly effective as an ethanol dehydrogenase, but highly effective as a retinol dehydrogenase ..
- Rat liver alcohol dehydrogenase of class III. Primary structure, functional consequences and relationships to other alcohol dehydrogenasesP Julia
Department of Chemistry I, Karolinska Institutet, Stockholm, Sweden
Eur J Biochem 172:73-83. 1988..Finally the class III structure supports evolutionary relationships suggesting that the three classes constitute clearly separate enzymes within the group of mammalian zinc-containing alcohol dehydrogenases...
- Human class IV alcohol dehydrogenase: kinetic mechanism, functional roles and medical relevanceShih Jiun Yin
Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, ROC
Chem Biol Interact 143:219-27. 2003Human alcohol dehydrogenase (ADH) constitutes a complex family. Class IV ADH (ADH4) is characteristic in its epithelial expression in the aerodigestive tract and high V(max) and K(m) for oxidation of ethanol...
- Characterization of the functional gene encoding mouse class III alcohol dehydrogenase (glutathione-dependent formaldehyde dehydrogenase) and an unexpressed processed pseudogene with an intact open reading frameM H Foglio
La Jolla Cancer Foundation Research Foundation, CA 92037, USA
Eur J Biochem 237:496-504. 1996..Reporter gene expression following transfection into mouse F9 embryonal carcinoma cells indicated that only Adh-2 possesses promoter activity...
- Excessive vitamin A toxicity in mice genetically deficient in either alcohol dehydrogenase Adh1 or Adh3Andrei Molotkov
Gene Regulation Program, Burnham Institute, La Jolla, CA 92037, USA
Eur J Biochem 269:2607-12. 2002..Here, Adh1, Adh3, and Adh4 null mutant mice have been examined following acute and chronic vitamin A excess...
- Polymorphism of the human alcohol dehydrogenase 4 (ADH4) promoter affects gene expressionH J Edenberg
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis 46202 5122, USA
Pharmacogenetics 9:25-30. 1999The human alcohol dehydrogenase 4 gene (ADH4) encodes the human pi-alcohol dehydrogenase (pi-ADH), which can contribute to ethanol metabolism at moderate and high concentrations of ethanol...
- The role of aryl hydrocarbon receptor in regulation of enzymes involved in metabolic activation of polycyclic aromatic hydrocarbons in a model of rat liver progenitor cellsJan Vondracek
Department of Cytokinetics, Institute of Biophysics ASCR, Brno, Czech Republic
Chem Biol Interact 180:226-37. 2009..In contrast, the aldehyde reductase AKR1A1 was not induced by either treatment...
- Aldose reductase: an aldehyde scavenging enzyme in the intraneuronal metabolism of norepinephrine in human sympathetic gangliaMinoru Kawamura
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Auton Neurosci 96:131-9. 2002..Although similar formation of DHPG was observed with human liver aldehyde reductase, the production of DHPG was more effective with aldose reductase than aldehyde reductase...
- Quantification of urinary aflatoxin B1 dialdehyde metabolites formed by aflatoxin aldehyde reductase using isotope dilution tandem mass spectrometryDenise N Johnson
Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
Chem Res Toxicol 21:752-60. 2008..This urinary detection of the alcohol products directly contributes to the goal of mass balancing the fate of the bioreactive 8,9-epoxides of AFB 1 in vivo...
- Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoterElizabeth M Ellis
Department of Bioscience and Pharmaceutical Sciences, University of Strathclyde, Glasgow G1 1XW, UK
Carcinogenesis 24:727-37. 2003Rat aflatoxin B(1) aldehyde reductase (called AFAR1 or AKR7A1) is a member of the aldo-keto reductase 7 family, which metabolizes the environmental carcinogen aflatoxin B(1)...
- Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteinsVincent P Kelly
Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
Biochem J 366:847-61. 2002The aldo-keto reductase (AKR) 7 family is composed of the dimeric aflatoxin B(1) aldehyde reductase (AFAR) isoenzymes. In the rat, two AFAR subunits exist, designated rAFAR1 and rAFAR2...
- Aldose reductase in human retinal pigment epithelial cellsS Sato
Laboratory of Ocular Therapeutics, National Eye Institute, National Institutes of Health, Bethesda, MD 20892
Exp Eye Res 57:235-41. 1993..In addition to aldose reductase, chromatofocusing demonstrated the presence of aldehyde reductase, another NADPH-dependent reductase...
- Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductaseC J Winters
Department of Medicine, Medical College of Virginia, Richmond 23298
Biochemistry 29:1080-7. 1990..The deduced protein sequence of CDR showed 65% similarity to the primary structure of human liver aldehyde reductase and 66% similarity to the inferred protein sequence of rat lens aldose reductase...
- Molecular cloning and expression of an abundant rabbit ovarian protein with 20 alpha-hydroxysteroid dehydrogenase activityW R Lacy
Department of Cell Biology, Baylor College of Medicine Houston, Texas 77030
Mol Endocrinol 7:58-66. 1993..to human chlordecone reductase, bovine lung prostaglandin F synthase, human aldose reductase, human aldehyde reductase, and frog lens rho-crystallin, placing rabbit ovarian 20 alpha HSD in the aldo-keto reductase family of ..
- Cloning of the human aflatoxin B1-aldehyde reductase gene at 1p35-1p36.1 in a region frequently altered in human tumor cellsC Praml
Division of Cytogenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Cancer Res 58:5014-8. 1998..a gene encoding a protein of 330 amino acids that is 78% identical with the Rattus norvegicus aflatoxin B1 aldehyde reductase (Afar) and, therefore, likely represents its human homologue...
- Enzymes of glycerol and glyceraldehyde metabolism in mouse liver: effects of caloric restriction and age on activitiesKevork Hagopian
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Biosci Rep 28:107-15. 2008..Aldehyde dehydrogenase and aldehyde reductase activities in both young and old CR mice were unchanged by caloric restriction...
- Enzymes in pancreatic islets that use NADP(H) as a cofactor including evidence for a plasma membrane aldehyde reductaseM Laclau
University of Wisconsin Childrens Diabetes Center, Madison, USA
Mol Cell Biochem 225:151-60. 2001..Significant activities of glutathione reductase, aldose reductase (EC.126.96.36.199) and aldehyde reductase (EC.188.8.131.52) were present in islets...
- Purification and characterization of human testis aldose and aldehyde reductaseT Tanimoto
Division of Biological Chemistry, National Institute of Hygienic Sciences, Tokyo, Japan
Int J Biochem 23:421-8. 19911. Aldose reductase and aldehyde reductase were purified to homogeneity from human testis. 2...
- Alcohol dehydrogenases in Xenopus development: conserved expression of ADH1 and ADH4 in epithelial retinoid target tissuesI Hoffmann
Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
Dev Dyn 213:261-70. 1998Mammalian alcohol dehydrogenases ADH1 (class I ADH) and ADH4 (class IV ADH) function as retinol dehydrogenases contributing to the synthesis of retinoic acid, the active form of vitamin A involved in growth and development...
- Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3Sridevi Bodreddigari
Department of Biology and W Harry Feinstone Center for Genomic Research, University of Memphis, Memphis, Tennessee 38152, USA
Chem Res Toxicol 21:1134-42. 2008..B 1 (AFB 1) dialdehyde metabolite to its corresponding mono and dialcohols, catalyzed by aflatoxin B 1-aldehyde reductase (AFAR, rat AKR7A1, and human AKR7A3), is greatly increased in livers of rats treated with numerous ..
- Characterization of the serotoninergic system in the C57BL/6 mouse skinAndrzej Slominski
Department of Pathology, University of Tennessee Health Science Center, Memphis, TN, USA
Eur J Biochem 270:3335-44. 2003..acid, probably through stepwise transformation catalyzed by monoamine oxidase, aldehyde dehydrogenase and aldehyde reductase. Activity of the melatonin-forming enzyme hydroxyindole-O-methyltransferase was notably below detectable ..
- Isolation of a set of genes expressed in the choroid plexus of the mouse using suppression subtractive hybridizationN Matsumoto
Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
Neuroscience 117:405-15. 2003..gelsolin, phospholipid transfer protein, ATP-binding cassette transporter A8 (ABCA8), androgen-inducible aldehyde reductase, and Na(+)/sulfate cotransporter SUT-1...
- Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the ratBill D Roebuck
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Toxicol Sci 109:41-9. 2009..These results imply that the prevention of protein adducts mediated by AKR are not critical to protection against AFB(1) tumorigenicity...
- A novel aldehyde reductase with activity towards a metabolite of aflatoxin B1 is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidantD J Judah
MRC Toxicology Unit, Carshalton, Surrey, U K
Biochem J 292:13-8. 1993In contrast with fractions from control animals, an aldehyde reductase, which catalyses the reduction of aflatoxin B1-dihydrodiol, in the dialdehyde form at physiological pH values, to aflatoxin B1-dialcohol, is expressed in cytosolic ..
- Biosynthesis of podophyllotoxin in Linum album cell culturesVeronique Seidel
Natural Products Research, Faculty of Applied Sciences, De Montfort University, The Gateway, Leicester LEI 9BH, UK
Planta 215:1031-9. 2002..Electronic supplementary material to this paper can be obtained by using the Springer LINK server located at http://dx.doi.org/wo.1007/s00425-002-0834-1...
- Purification and characterization of a novel cytosolic NADP(H)-dependent retinol oxidoreductase from rabbit liverD Y Huang
Department of Biochemistry, School of Medicine, Kagawa Medical University, Japan
Biochim Biophys Acta 1338:47-59. 1997..This enzyme exhibits relatively broad aldehyde reductase activity and some ketone reductase activity, the activity for aromatic substitutive aldehydes being ..
- Escherichia coli YqhD exhibits aldehyde reductase activity and protects from the harmful effect of lipid peroxidation-derived aldehydesJose Manuel Perez
Laboratorio de Microbiologia Molecular, Departamento de Biologia, Facultad de Quimica y Biologia, Universidad de Santiago de Chile, Santiago 9170019, Chile
J Biol Chem 283:7346-53. 2008..We speculate that in Escherichia coli YqhD is part of a glutathione-independent, NADPH-dependent response mechanism to lipid peroxidation...
- Cloning and expression of two novel aldo-keto reductases from Digitalis purpurea leavesIsabel Gavidia
Center of Plant Molecular Biology ZMBP, University of Tubingen, Germany
Eur J Biochem 269:2842-50. 2002..proteins present high identities (68-80%) with four Arabidopsis clones and a 67% identity with the aldose/aldehyde reductase from Medicago sativa...
- Structural similarity of bovine lung prostaglandin F synthase to lens epsilon-crystallin of the European common frogK Watanabe
Hayaishi Bioinformation Transfer Project, Kyoto Laboratory, Research Development Corporation of Japan
Proc Natl Acad Sci U S A 85:11-5. 1988..that bovine lung PGF synthase shows 62% identical plus conservative substitutions compared with human liver aldehyde reductase [Wermuth, B., Omar, A., Forster, A., Francesco, C., Wolf, M., Wartburg, J.P., Bullock, B. & Gabbay, K.H...
- Proteomic analysis of pancreatic ductal adenocarcinoma compared with normal adjacent pancreatic tissue and pancreatic benign cystadenomaYazhou Cui
Key Laboratory of Ministry of Health for Biotech Drug, Shandong Medicinal Biotechnology Center, Shandong Academy of Medical Sciences, Jinan, PR China
Pancreatology 9:89-98. 2009..Dual expression of potential biomarkers in both benign and malignant pancreatic tumors was a major obstacle in the development of diagnostic biomarkers of early pancreatic cancer...
- Carbonyl reductases and pluripotent hydroxysteroid dehydrogenases of the short-chain dehydrogenase/reductase superfamilyFrank Hoffmann
Institute of Toxicology and Pharmacology for Natural Scientists, University Medical School Schleswig Holstein, Campus Kiel, Brunswiker Strasse, Kiel, 10, 24105, Germany
Drug Metab Rev 39:87-144. 2007..Whereas aldehyde reductase and aldose reductase are AKRs, several forms of carbonyl reductase belong to the SDRs...
- Metyrapone reductase purified partially from liver microsomes of male rats: the enzyme differs from acetohexamide reductaseY Imamura
Faculty of Pharmaceutical Sciences, Kumamoto University, Japan
Res Commun Mol Pathol Pharmacol 96:219-26. 1997..The substrate specificities were in fair agreement with those of carbonyl reductase. However, the partially purified enzyme was strongly inhibited by inhibitors of aldehyde reductase, such as barbital, phenobarbital and sodium valproate.
- Aldose reductase from human psoas muscle. Affinity labeling of an active site lysine by pyridoxal 5'-phosphate and pyridoxal 5'-diphospho-5'-adenosineN A Morjana
Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
J Biol Chem 264:2912-9. 1989..the essential lysine was found to be highly homologous with a segment of the sequence of both human liver aldehyde reductase and rat lens aldose reductase...
- Molecular cloning and expression of rat liver 3 alpha-hydroxysteroid dehydrogenaseK C Cheng
Department of Pediatrics Cornell University Medical College, New York, New York 10021
Mol Endocrinol 5:823-8. 1991..other enzymes, including bovine prostaglandin F synthase, human chlordecone reductase, human aldose reductase, human aldehyde reductase, and frog lens epsilon-crystalline, suggesting that these proteins belong to the same gene family.
- Developmental expression and function of aldehyde reductase in proximal tubules of the kidneyOleg A Barski
Harry B and Aileen Gordon Diabetes Research Laboratory, Baylor College of Medicine, Houston, Texas, USA
Am J Physiol Renal Physiol 289:F200-7. 2005b>Aldehyde reductase reduces a wide variety of toxic and physiological aldehydes with a marked preference for negatively charged substrates such as glucuronate...
- Polyol formation in cell lines of rat retinal capillary pericytes and endothelial cells (TR-rPCT and TR-iBRB)Peter F Kador
Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198 6025, USA
J Ocul Pharmacol Ther 25:299-308. 2009....
- Production of medium chain length fatty alcohols from glucose in Escherichia coliJ Tyler Youngquist
Department of Chemical and Biological Engineering, University of Wisconsin Madison, 3629 Engineering Hall, 1415 Engineering Drive, Madison, WI 53706, United States Great Lakes Bioenergy Research Center, University of Wisconsin Madison, Madison, WI 53706, United States
Metab Eng 20:177-86. 2013..1-dodecanol and 1-tetradecanol, an acyl-ACP thioesterase (BTE), an acyl-CoA ligase (FadD), and an acyl-CoA/aldehyde reductase (MAACR) were overexpressed in an engineered strain of Escherichia coli...
- Aldehyde reductase isozymes in the mouse: evidence for two new loci and localization of Ahr-3 on chromosome 7P B Mather
Biochem Genet 23:483-96. 1985Evidence is presented for two new forms of mouse liver and kidney aldehyde reductase activity (designated AHR-3 and AHR-4) resolved using cellulose acetate electrophoresis zymogram techniques and stained by glyceraldehyde and NADPH as ..
- Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductaseB Wermuth
J Biol Chem 256:1206-13. 1981A nonspecific NADPH-dependent carbonyl reductase from human brain (formerly designated as aldehyde reductase 1; Ris, M. M., and von Wartburg, J. P. (1973) Eur. J. Biochem. 37, 69-77) has been purified to homogeneity...
- Competing roles of cytochrome P450 1A1/1B1 and aldo-keto reductase 1A1 in the metabolic activation of (+/-)-7,8-dihydroxy-7,8-dihydro-benzo[a]pyrene in human bronchoalveolar cell extractsHao Jiang
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6084, USA
Chem Res Toxicol 18:365-74. 2005..TCDD) to express P450 1A1/P450 1B1 or by stable transfection to express AKR1A1 (aldehyde reductase). TCDD induction of AKR1A1 transfectants provided a cell line that expressed both pathways...
- Multiplicity of mammalian reductases for xenobiotic carbonyl compoundsToshiyuki Matsunaga
Laboratory of Biochemistry, Gifu Pharmaceutical University, Japan
Drug Metab Pharmacokinet 21:1-18. 2006..member 4, 11beta-hydroxysteroid dehydrogenase type 1, L-xylulose reductase, two types of aflatoxin B1 aldehyde reductase, 20alpha-hydroxysteroid dehydrogenase, and three types of 3alpha-hydroxysteroid dehydrogenase...
- Gene regulation of aldose-, aldehyde- and a renal specific oxido reductase (RSOR) in the pathobiology of diabetes mellitusFarhad R Danesh
Departments of Pathology and Medicine, Northwestern University Medical School, Chicago, Illinois, USA
Curr Med Chem 10:1399-406. 2003..During the past three decades aldehyde reductase (AKR1A) and aldose reductase (AKR1B) have been extensively investigated, and the gene regulation of AKR1B ..
- Efficient production of recombinant aldehyde reductase and its application for asymmetric reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoateKeju Jing
Institute of Bioengineering, Department of Chemical Engineering and Bioengineering, Zhejiang University, Hangzhou, PR China
Prep Biochem Biotechnol 35:203-15. 2005An NADPH-dependent aldehyde reductase (ALR, EC184.108.40.206) gene is cloned from Sporobolomyces salmonicolor ZJUB 105, and inserted into plasmid pQE30 to construct the expression plasmid (pQE30-ALR). A variety of E...
- Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivityOssama El-Kabbani
Department of Medicinal Chemistry, Victorian College of Pharmacy, Monash University Parkville Campus, 381 Royal Parade, VIC 3052, Australia Ossama El Kabbani vcp monash edu au
J Med Chem 48:5536-42. 2005Structure determination of porcine aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat was carried out to explain the difference in the potency of the inhibitor for aldose and aldehyde reductases...
- Association of VMAT2 gene polymorphisms with alcohol dependenceChristoph Fehr
Department of Psychiatry and Psychotherapy, University of Mainz, Untere Zahlbacher Str 8, 55131, Mainz, Germany
J Neural Transm 120:1161-9. 2013..Few candidate genes have been identified, comprising ADH4, ALDH2, COMT, CRHR1, DAT (SLC6A3), GABRA2 and MAOA...
- Effect of alcohol and aldehyde dehydrogenase gene polymorphisms on alcohol-associated hypertension: the Guangzhou Biobank Cohort StudyWei Sen Zhang
Molecular Epidemiological Research Centre, Guangzhou No 12 Hospital, Guangzhou, China
Hypertens Res 36:741-6. 2013..ADH2 genotype influences blood pressure and risk of hypertension among male alcohol drinkers, suggesting that the hypertensive effect of alcohol is due to ethanol rather than acetaldehyde. ..
- Transamination in the metabolism of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide in ratsDonghui Cui
Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, 600 South 43 Street, Philadelphia, PA 19104 4495, USA
Drug Metab Dispos 33:1765-70. 2005..Results from these studies show that transamination is a metabolic pathway in the clearance of NDPS in rats, and that cytosolic dehydrogenases and aminotransferases may be involved in this process...
- Molecular cloning of rat liver 3α-hydroxysteroid dehydrogenase and identification of structurally related proteins from rat lung and kidneyK C Cheng
Department of Pediatrics, Cornell University Medical College, New York, NY 10021, USA
J Steroid Biochem Mol Biol 43:1083-8. 1992..such as bovine prostaglandin F synthase, human chlordecone reductase, human aldose reductase, human aldehyde reductase and frog lens epsilon-crystallin, suggesting that these proteins belong to the same gene family...
- High-resolution structure of AKR1a4 in the apo form and its interaction with ligandsFrédérick Faucher
Department of Biomedical and Molecular Sciences, Queen s University, Kingston, Ontario K7L 3N6, Canada
Acta Crystallogr Sect F Struct Biol Cryst Commun 68:1271-4. 2012Aldo-keto reductase 1a4 (AKR1a4; EC 188.8.131.52) is the mouse orthologue of human aldehyde reductase (AKR1a1), the founding member of the AKR family. As an NADPH-dependent enzyme, AKR1a4 catalyses the conversion of D-glucuronate to L-gulonate...
- Comparative proteomics of skeletal muscle mitochondria from myostatin-null miceJonathan Puddick
Department of Biological Sciences, Faculty of Science and Engineering, The University of Waikato, Private Bag 3105, Hamilton, New Zealand
Cell Biol Int Rep (2010) 18:e00013. 2011..This protein, having a sequence similar to that of aldehyde reductase, was up-regulated in myostatin-null mitochondria, but its importance was not established, although it might ..
- Influence of broccoli extract and various essential oils on performance and expression of xenobiotic- and antioxidant enzymes in broiler chickensKristin Mueller
Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
Br J Nutr 108:588-602. 2012..SFN, Cuo and Ro increased the expression of xenobiotic enzymes (epoxide hydrolases 1 and 2 and aflatoxin B1 aldehyde reductase) and of the antioxidant enzyme haeme oxygenase regulated by an 'antioxidant response element' (ARE) compared ..
- Benzo(a)pyrene induces hepatic AKR1A1 mRNA expression in tilapia fish (Oreochromis niloticus)Citlalli Osorio-Yáñez
Departamento de Toxicologia, Centro de Investigacion y de Estudios Avanzados del IPN, San Pedro Zacatenco, Mexico City, Mexico
Toxicol Mech Methods 22:438-44. 2012AKR1A1 or aldehyde reductase is a member of the aldo-keto reductases superfamily that is evolutionarily conserved among species...
- Glyoxylate metabolism is a key feature of the metabolic degradation of 1,4-dioxane by Pseudonocardia dioxanivorans strain CB1190Ariel Grostern
Department of Civil and Environmental Engineering, University of California, Berkeley, Berkeley, California, USA
Appl Environ Microbiol 78:3298-308. 2012..Plasmid-borne genes for putative aldehyde dehydrogenases, an aldehyde reductase, and an alcohol oxidoreductase were also induced during growth with dioxane...
- Differential protein expression in honeybee (Apis mellifera L.) larvae: underlying caste differentiationJianke Li
Key Laboratory of Pollinating Insect Biology, Department of Beekeeping and Biotechnology, Ministry of Agriculture, Institute of Apicultural Research, Chinese Academy of Agricultural Science, Beijing, China
PLoS ONE 5:e13455. 2010..Specifically, at 72 hours, queen intended larvae over-expressed transketolase, aldehyde reductase, and enolase proteins which are involved in carbohydrate metabolism and energy production, imaginal disc ..
- Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining featuresHolger Steuber
Department of Pharmaceutical Chemistry, Philipps University Marburg, Marbacher Weg 6, 35032 Marburg, Germany
J Mol Biol 379:991-1016. 2008..bioavailability, putative inhibitors should possess a high level of selectivity for ALR2 over the related aldehyde reductase (ALR1)...
- Proteomics of cauda epididymal fluid from mature Holstein bullsArlindo A Moura
Department of Animal Science, Federal University of Ceara, Brazil
J Proteomics 73:2006-20. 2010..N-acetyl-β-glucosaminidase, cauxin, glutathione peroxidase, acidic seminal fluid protein (aSFP), aldehyde reductase, α-l-fucosidase, α-1-β-glycoprotein, apolipoprotein A-1, β actin, calmodulin, cathepsin D, cystatin E/M, ..
- Tissue expression pattern of class II and class V genes found in the Adh complex on mouse chromosome 3Gabor Szalai
Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA
Biochem Genet 46:685-95. 2008..The expression patterns at the mRNA level of the mouse Adh4 (class II) gene and the recently identified Adh6a and Adh6b genes (class V) are now reported to complete this ..
- Medium- and short-chain dehydrogenase/reductase gene and protein families : Medium-chain and short-chain dehydrogenases/reductases in retinoid metabolismX Pares
Department of Biochemistry and Molecular Biology, Universitat Autonoma de Barcelona, Bellaterra, Spain
Cell Mol Life Sci 65:3936-49. 2008..ADH1 and ADH2 are the major MDR enzymes in liver retinol detoxification, while ADH3 (less active) and ADH4 (most active) participate in RA generation in tissues...
- Salivary amylase induction by tannin-enriched diets as a possible countermeasure against tanninsG da Costa
ITQB Instituto de Tecnologia Química e Biológica, Oeiras, Portugal
J Chem Ecol 34:376-87. 2008..One isoform of alpha-amylase was overexpressed with both types of tannins. Aldehyde reductase was only identified in saliva of the quebracho group...
- Transcriptional activation of the aldehyde reductase YqhD by YqhC and its implication in glyoxal metabolism of Escherichia coli K-12Changhan Lee
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Yuseong Gu, Daejeon, Republic of Korea
J Bacteriol 192:4205-14. 2010..Therefore, we propose that YqhC is a transcriptional activator of YqhD, which acts as an aldehyde reductase with specificity for certain aldehydes, including GO.
- Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complicationsMichael C Van Zandt
The Institute for Diabetes Discovery, LLC, 23 Business Park Drive, Branford, CT 06405, USA
Bioorg Med Chem Lett 19:2006-8. 2009..acid example 16, inhibits aldose reductase with an IC50 of 8 nM, while being inactive against aldehyde reductase (IC50>100 microM), a related enzyme involved in the detoxification of reactive aldehydes.
- Prevalidation of potential protein biomarkers in toxicology using iTRAQ reagent technologyMatthias Glückmann
Applied Biosystems, Mass Spectrometry and Proteomics, Darmstadt, Germany
Proteomics 7:1564-74. 2007..g. placental form of glutathione S-transferase (GST-P), carbonic anhydrase, and aflatoxin B1 aldehyde reductase. Our results show both the usefulness of iTRAQ reagent technology for biomarker prevalidation as well as for ..
- Mammalian alcohol dehydrogenases--a comparative investigation at gene and protein levelsJan Olov Höög
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
Chem Biol Interact 191:2-7. 2011..The transcriptional order for the ADH genes in all mammalian genomes is the same (ADH4-ADH1-ADH6-ADH5-ADH2-ADH3), but the cluster is found on different chromosomes in different species...
- A root proteomics-based insight reveals dynamic regulation of root proteins under progressive drought stress and recovery in Vigna radiata (L.) WilczekDebashree Sengupta
Photosynthesis and Plant Stress Biology Laboratory, Department of Plant Sciences, School of Life Sciences, University of Hyderabad, Hyderabad 500046, India
Planta 233:1111-27. 2011..Oxidative stress-related proteins including Cu/Zn superoxide dismutase, oxidoreductase and aldehyde reductase were also up-regulated...
- A common telomeric gene silencing assay is affected by nucleotide metabolismMarlies P Rossmann
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
Mol Cell 42:127-36. 2011..imbalance in ribonucleotide reductase (RNR), which is induced by 5-FOA, and the specific promoter of URA3 fused to ADH4 at telomere VII-L are jointly responsible for the variegated phenotype...
- Xenobiotic-Metabolizing gene polymorphisms and ovarian cancer riskEllen L Goode
Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Mol Carcinog 50:397-402. 2011..956 of serous sub-type) and controls (N = 2046) from three studies were genotyped at 11 SNPs in EPHX1, ADH4, ADH1A, NQO2, NAT2, GSTP1, CYP1A1, and NQO1, following an initial SNP screen in a subset of participants...
- Association of alcohol dehydrogenase genes with alcohol-related phenotypes in a Native American community sampleIan R Gizer
Department of Psychological Sciences, University of Missouri, Columbia, Missouri, USA
Alcohol Clin Exp Res 35:2008-18. 2011....
- Age-related changes in activity of enzymes catalyzing oxidation-reduction of endogenous aldehydes in the liver of rats during immobilization stressV V Davydov
Laboratory of Age Specific Endocrinology and Metabolism, Institute of Child and Adolescent Health Protection, Academy of Medical Sciences, Kharkov
Bull Exp Biol Med 141:17-9. 2006Activities of aldehyde dehydrogenase and aldehyde reductase in the liver 1.5-, 12-, and 24-month-old rats were measured after 30-min immobilization...
- Solid-phase translation and RNA-protein fusion: a novel approach for folding quality control and direct immobilization of proteins using anchored mRNAManish Biyani
Rational Evolutionary Design of Advanced Biomolecules, Saitama Small Enterprise Promotion Corporation SKIP City, 3 12 18 Kamiaoki, Kawaguchi, Saitama 333 0844, Japan
Nucleic Acids Res 34:e140. 2006..production of immobilized green fluorescent protein (GFP) on microbeads and by the production and assay of aldehyde reductase (ALR) enzyme with 4-fold or more activity...
- [Research on associations between selected polymorphisms of genes DRD2, 5HTT, GRIK3, ADH4 and alcohol dependence syndrome]Elzbieta Grochans
Samodzielna Pracownia Propedeutyki Pielegniarstwa PUM w Szczecinie
Psychiatr Pol 45:325-35. 2011..Alcohol abuse is a complex multifactorial disease. It is believed that alcohol dependence is mostly caused by genetic (40-50%) and environmental (50-60%) factors...
- Proteomic changes of PC12 cells treated with proteasomal inhibitor PSILei Zhang
Department of Neurology, The First Hospital, Jilin University, Changchun 130021, China
Brain Res 1153:196-203. 2007..glucose-regulated protein (GRP94), heat shock 70 kDa protein 5 (GRP78), heat shock 27 kDa protein 1 (Hsp27), aldehyde reductase 1 (aldose reductase), p47 protein and beta-galactoside-binding lectin (galectin-1)...
- Activity variation in alcohol dehydrogenase paralogs is associated with adaptation to cactus host use in cactophilic DrosophilaLuciano M Matzkin
Department of Ecology and Evolution, State University of New York at Stony Brook, Stony Brook, New York 11794 5245, USA
Mol Ecol 14:2223-31. 2005..Both functional and sequence variation within and between paralogs suggests that Adh has played an important role in the adaptation of D. mojavensis and D. arizonae to their cactophilic life...
- Substrate specificity of an aflatoxin-metabolizing aldehyde reductaseE M Ellis
Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, U K
Biochem J 312:535-41. 1995..Determination of the apparent Km reveals that AFAR has highest affinity for 9,10-phenanthrenequinone and succinic semialdehyde, and low affinity for glyoxal and DL-glyceraldehyde...
- A potent aldose reductase inhibitor, (2S,4S)-6-fluoro-2', 5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide (Fidarestat): its absolute configuration and interactions with the aldose reductase by X-ray crystallographyM Oka
Rational Drug Design Laboratories, 4 1 1, Misato, Matsukawa machi, Fukushima 960 1242, Japan
J Med Chem 43:2479-83. 2000..group of fidarestat was a very effective substituent for affinity to AR and for selectivity between AR and aldehyde reductase (AHR)...
- Identification of genes expressed in the amygdala during the formation of fear memoryO Stork
Laboratory of Neurochemistry, National Institute for Physiological Sciences, Okazaki 444 8585, Japan
Learn Mem 8:209-19. 2001..In particular, a key enzyme of monoamine metabolism, aldehyde reductase, and the protein sorting and ubiquitination factor Praja1, showed pronounced and learning-specific induction ..
- Role of extrahepatic alcohol dehydrogenase in rat ethanol metabolismM D Boleda
Department de Bioquimica i Biologia Molecular, Facultat de Ciencies, Universitat Autonoma de Barcelona, Bellaterra, Spain
Arch Biochem Biophys 274:74-81. 1989..4 microM) and indicate that at the usual concentration of inhibitor only ADH-3 activity will be effectively suppressed. ADH-1 will be, therefore, responsible in part for the residual ethanol oxidation activity in pyrazole-treated rats...
- The Drosophila alcohol dehydrogenase gene may have evolved independently of the functionally homologous medfly, olive fly, and flesh fly genesS Brogna
Institute of Molecular Biology and Biotechnology, Research Center of Crete, Foundation for Research and Technology, Heraklion, Crete, Greece
Mol Biol Evol 18:322-9. 2001..To explain this unexpected finding, it is proposed that the ADH: genes of the family Drosophilidae may not be orthologous to the ADH: genes of the other two families, Tephritidae and Sarcophagidae...
- Enzymatic conversion of prostaglandin H2 to prostaglandin F2 alpha by aldehyde reductase from human liver: comparison to the prostaglandin F synthetase from bovine lungH Hayashi
Hayaishi Bioinformation Transfer Project, Research Development Corporation of Japan
J Biol Chem 264:1036-40. 1989..structure of prostaglandin (PG) F synthetase from bovine lung shows 62% similarity with that of human liver aldehyde reductase (EC 18.104.22.168) (Watanabe, K., Fujii, Y., Nakayama, K., Ohkubo, H., Kuramitsu, S., Kagamiyama, H., Nakanishi, S...
- Androgen-regulated expression of a novel member of the aldo-keto reductase superfamily in regrowing rat prostateN Nishi
Department of Endocrinology, Faculty of Medicine, Kagawa Medical University, Japan
Endocrinology 141:3194-9. 2000..the former a new member of the rat aldo-keto reductase superfamily that is closely related to aflatoxin, B1 aldehyde reductase has been identified...
Research Grants12
- Protein Modification by 3,4-DihydroxyphenylacetaldehydeJONATHAN DOORN; Fiscal Year: 2006..metabolized primarily to an acid via mitochondrial aldehyde dehydrogenase (ALDH2) but also to an alcohol by aldehyde reductase (ALR). Recent work implicates oxidative stress and lipid peroxidation products, e.g...
- ALCOHOL METABOLISM GENES IN TRANSGENIC MICEMichael Felder; Fiscal Year: 2007..alcohol-induced liver damage Distal cis-linked sequence in a BAC clone will direct expression of Adh1 in liver and Adh4 in stomach No sequence directing liver expression of any human class I ADH gene is known...
- STRUCTURE & EXPRESSION OF MAMMAL ALC DEHYDROGENASE GENESHoward Edenberg; Fiscal Year: 2000..The ADH4, ADH5, ADH6 and ADH7 genes have different patterns of expression, and produce enzymes (PI-ADH, X-ADH, ADH6 and ..
- ALDO-KETO REDUCTASES AS PART OF CHEMICAL STRESS RESPONSEOleg Barski; Fiscal Year: 2002..Recently it was shown that ethoxyquin and antiobiotic tunicamycin also induce aldehyde reductase, another member of the aldo-keto reductase family...
- Molecular Mechanisms of Multistage CarcinogenesisTREVOR PENNING; Fiscal Year: 2006..Project # 1 (Dr. Penning) will compare the roles of human aldehyde reductase (AKR1A1), CYP1A1/CYP1B1, and CYP-peroxidase in the metabolic activation of PAH using a stable expression ..
- STRUCTURAL IDENTIFICATION OF PROSTAGLANDIN CONJUGATESL Roberts; Fiscal Year: 2000..The ability of PGF-synthase and liver aldehyde reductase to reduce IsoP endoperoxides to F-ring IsoP's will also be examined...
- Enzyme & Receptor Antagonists of GHB, GBL & 1, 4-BDLawrence Quang; Fiscal Year: 2003..The results of this study will expand upon promising data from pilot studies performed in this laboratory on acute 1,4-BD and GHB toxicity as well as novel therapeutic agents for its potential medical management. ..
- Alopecia and Ulcerative Dermatitis in B6 MiceJohn Sundberg; Fiscal Year: 2007..B6 mice are naturally hypomorphic for alcohol dehydrogenase 4 (Adh4), which may be involved in detoxifying vitamin A metabolites resulting in these enzyme expression ..
- Diet, gene-diet interactions and risk of Parkinson'sHonglei Chen; Fiscal Year: 2004..NHS cohorts, he will evaluate the associations of PD risk with common polymorphisms of NAT2, CYP1A2, ADH2, ADH3, ADH4, and MTHFR...
- Alcohol in Israel: Genetic and Environmental EffectsDeborah Hasin; Fiscal Year: 2007..ADH3 and promoters of ADH4 and ALDH2 will also be studied. Psychiatric comorbidity, religiosity and trauma will be assessed and controlled...
- ALDO/KETO REDUCTASES AND DIABETIC COMPLICATIONSKENNETH GABBAY; Fiscal Year: 2001DESCRIPTION (Adapted from applicant's abstract): Aldose and aldehyde reductase are closely related members of the aldo-keto reductase superfamily...
- GENETIC DISSECTION OF ALCOHOL/RETINOL METABOLIC PATHWAYSGregg Duester; Fiscal Year: 2002..3) Prepare and ALDH-I knockout mouse plus mice mutated for one or more ADHs and ALDH-I, then analyze their phenotype as above. ..


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Bridgfordians bounce back to form
West Bridgfordians (227) got back to form in Division B at home to Long Eaton (138), after a couple of indifferent performances.
The hosts had Andrew Sharpe (80) and Henry Straw (45) sharing the plaudits while Mark Harrison (6-55) battled well from one end.
The visitors were never at the races and with the exception of Andy Edge (51) it was a poor performance with the bat as Oliver Straw grabbed five wickets.
Collingham have a win at the fourth attempt as they overcame the challenge of fellow strugglers Gotham (185) in a quick return fixture.
Experience was the key for the winners with Joe Edge (48), Ben Hazledine (38) and Karl Tew (4-56) all playing key roles in a four-wicket win.
Kimberley II are now the outright leaders in C but they were pushed all the way by neighbours Newstead Village.
Mick Blatherwick returned to the seconds and top scored with 64, while James Griffiths who has not been required to date, contributed 48.
A decent second-wicket stand between Danny Greenhalgh (32) and Adam Kalka (60) gave the visitors hope while Steve Daykin (36) did his best in the middle order but ultimately 223 proved too stiff a task with the innings closing on 190.
For the winners, Steve Bennett (3-43) and Craig Pitts (2-34) both promoted from the third team were the best bowlers.
The other joint leader prior to Saturday were Radcliffe-on-Trent II who endured a nightmare at home to Wollaton II who had Richard Cooper (5-35) starring again with the ball. A total of 111 proved no obstacle for Sunil Sharma (50*) and John Gulson (32*).
Another thrilling climax came at Gedling Colliery II, who were chasing 189 set by Attenborough II.
With wickets falling around him, sixteen-year-old Connor O'Brien, who had earlier took four wickets, became the hero with an unbeaten 42 as the home side squeezed through with one wicket intact.
Thurgarton are still winless and it was a case of what might have been at home to Wilsons. The visitors were 50-5 at one stage, yet the tail end of Doud Ali (45), Arslan Shahid (32) and Imran Shahid (35*) managed to get the score up to 210. Colin Cliff (70) made his first major contribution of the season after the interval, but he lacked the support required as the home side fell to a 39 run reversal.
Kirkby Portland got their act together, posting a mammoth 299 with Joe Caunt (73) and Richard Underhill (66) the chief run getters.
Opponents Hoveringham, who are finally finding the step up a steep one came a distant second with 218 despite the best efforts of Shaun Polley (63).
For more local news and sport visit The Nottingham Post.
NCB News
John Cope 06/10/2015
Death of former Cricket Development Manager announced.... more
Recruitment of Apprentices & Co-ordinator - Team Nottingham 02/10/2015
12 month roles to support Team Nottinghamshire Initiative... more
NatWest OSCAs Nomination for Harry Johnson 28/09/2015
Smith Cooper apprentice nominated for national award... more


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Maryland's Pfiesteria Response
June 22, 1998 Update
Water Quality and Fish Health:
State agencies have responded to two localized fish health problems that generated some concern. First, in mid-May, dead and lesioned catfish were reported in Back River. Fish health problems are not uncommon during the Spring and Summer on this heavily nutrient enriched tributary. Bacterial infection was suspected, but samples for Pfiesteria were collected as a precaution. The Pfiesteria samples were negative, and subsequent investigations confirmed a bacterial species (Flexibactor) as the cause of the problem. Second, intermittent reports of dead white perch have been received from both sides of the Potomac River in the vicinity of the Route 301 bridge since early May. Follow-up investigations have also found a higher than normal percentage of white perch with lesions from this area. The type of lesions observed did not suggest Pfiesteria as the cause, but samples were collected as a precaution. Again, results of the Pfiesteria analysis were negative. Preliminary results of an on-going investigation in collaboration with researchers at University of Maryland suggest a bacterial infection as the cause. More definitive results from this investigation are expected in the very near future.
Rapid Response teams are in place and ready to evaluate fish health problems as they are reported to the Fish Health Hotline (1-888-584-3110). To date, Rapid Response teams have investigated 16 fish health events, all of which were explained by factors other than Pfiesteria. Additionally, a field office has been established in Vienna, and is now operational.
Pocomoke Watershed Pollution Source Assessment: The watershed pollution source assessment is designed to identify all major contributors of pollutants to the Pocomoke River and to evaluate the effectiveness of on-going pollution control efforts. To date, State and federal agencies have worked together to measure base and storm flow water quality at several sites in the watershed, as well as sediment grain size and phosphorus concentrations both in the river mainstem and several tributaries. Samples collected during this effort are currently being analyzed by the laboratories. Information derived as part of this effort will be synthesized with the results of the on-going "paired watershed" study in the upper watershed, which seeks to evaluate the impact of various agricultural practices on water quality.
Chemical Contaminants: Analysis of chemical contaminants in the lower Pocomoke River following last summer's fish kills and lesion events revealed no significant levels of contaminants. More samples were collected twice this spring (May 9,11 and June 13,15) during storm runoff events after the period of peak agricultural pesticide application. It is expected to take a couple months for analysis to be completed on these samples.
Federal Coordination: Representatives of Maryland State agencies are working closely with federal partners (primarily EPA and NOAA) to ensure a coordinated regional response to the threat of Pfiesteria outbreaks. Levels of interaction are many, but include standardization of sampling and data management protocols, coordination of sample analysis and data interpretation with the two primary laboratories (Dr. JoAnn Burkholder at North Carolina State University and Dr. Karen Steidinger at Florida Department of Environmental Protection), and the development of an Internet "listserver" that allows rapid communication of breaking events among key State and federal representatives. In many cases, Maryland's strategy for responding to the threat of Pfiesteria is being used as a model for adoption by other states along the Atlantic coast.
Search Maryland DNR
Restoration and
Protection | Bay Grasses |
Algae | Bay Monitoring
Return to the Maryland
DNR Home Page.


text:
Production of talking books on audiocassettes has ceased. Only digital talking books will be produced from now into the future. Though magazines and older titles in the NLS collection will still be available on audiocassette, by the end of 2011 Talking Book Topics will list only digital talking-book (DB) titles. If you do not already have a digital talking-book player, please request one from your network library.
In addition to reading talking books on NLS-produced digital cartridges, patrons may download talking books from the Braille and Audio Reading Download (BARD) website. You will need a computer with a high-speed Internet connection, a blank cartridge, a USB cable, and an NLS digital talking-book player or NLS-authorized commercial player. Find out more at https://nlsbard.loc.gov/ApplicationInstructions.html.
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Four recent graduates of Northeastern University won the 2010 Louis Braille Touch of Genius Prize for Innovation for building a low-cost braille embosser converted from a standard ink-jet printer. Molly Brown, Ben Braggins, Patrick Cleary, and Jeff Witkowski received the $10,000 prize on September 29, 2010, at the Microsoft New England Research and Development Center in Cambridge, Massachusetts. Northeastern University has applied for a provisional patent for the invention.
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Great Tee
I loved the look of this tee so much, I bought three, in different colors. They drape beautifully and feel great against the skin. I got them at a great bargain price, so I can't complain too much about the one negative that I do have: I bought all the tees in Medium size, but each one, though marked clearly as Medium, was a different size. One was very large, one was very small, and one was an actual medium. I was fortunate to be able to wear them all, but beware that this could be an issue for you. This is not the first time I've come up against this problem with MetroStyle. I purchased denim leggings that were all very large.
Emory, TX
love this top
The acid washed tee is a great fit, nice feeling material, my new favorite tops, bought all three colors.
PUeblo, Colorado