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Awesome shot, Great depth in the eyes…
Encore une belle réussite ce portrait.
Lot of questions hidden behind the veil of silence.
great shot!
Amazing picture. The expression captures attention.
Great shot!! Nice portrait!
Splendid portrait of this man with his special appearance
Sharpness perfect onhis eyes .
Those eyes are piercing. Nice capture.
nice shot
Well captured face with a certain sadness to it.
looking great with well captured………….
Another fabulous shot, Joshi! Fantastic portrait! :)
Amazing eyes!
Very good photo very expressive.
A greeting.
Tu es le maitre des beaux portraits
Amazing regard and portrait ! Great work my friend ! Have a nice week-end :-)
such a powerful portrait
Love the intensity!
I agree with others here; there is a deep intensity in this man's eyes that probably reflects what he experiences in his life and work. Fine work, Joshi.
fantastic eyes! like it! :)
Excellent portrait.
he has got beautiful eyes :)) beautifully captured :))
The depth in the eyes, sooo sad, awesome picture
The kind of silence that speaks louder than a thousand words!
Pretty intense eyes captured cleverly .
I would say an intense gaze


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Each year, this incredible "party with a purpose" celebrates Essence Magazine by gathering up some of the best acts in R&B music to perform for three fantastic days inside the Mercedes-Benz Superdome in New Orleans Louisiana. It's long be heralded as one of the most exciting cultural events in the country, and with Essence Festival tickets you can be there live for every performance, seminar, and more. In the past, stars like Beyonce, Kanye West, Usher, Patti Labelle, Jill Scott, Erykah Badu, and Mary J. Blige have taken the stage, and this year will be just as incredible. Now is the time to claim your 2015 Essence Festival tickets and prepare yourself for three marvelous days on music and inspiration in the Big Easy. Here are just a couple of the reasons why Vivid Seats should be the place you buy your Essence Festival tickets:
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Monday, December 3, 2012
© Copyright 2015 Albany Herald
Watching my nephew grow remains the highlight of my life. Yep, he is still learning and still growing. In what seems like an overnight process, I have watched him grow and grow right out of diapers, clothes and shoes on into bigger and bigger sizes in each. He is 6 years old now.
As I thought on this fascinating phenomenon of growth, I was reminded of the days when dolls and the "days of the week" underwear weren't gonna cut it anymore. GI Joe figurines and kisses from the folks in front of the buddies were a no-no. I thought about how at a certain stage of growth, for some, the apartment becomes too small and the search is on for a house with more space. The two-door sports car is traded for a four-door sedan and the four-door sedan is later replaced by a sliding door mini-van.
I thought about when some reached that point where the late night partying and early morning hangovers lost their appeal. Then, there is the question about what you ever saw in that girlfriend/boyfriend or that clique you hung with back in high school or even in college.
What it boiled down to was that the phenomenon occurring with my nephew as a young child is the same one we experience at many other times in our lives. Put simply, we just outgrow things and, sometimes, people.
In a lot of cases, thank goodness for growth, right?
Yes, and we should embrace our growth. I have found that often some of us choose to be stifled or to allow ourselves to be limited in our ambitions because we are trying to fit into a friendship or relationship that is no longer our size.
We hang onto friends who we once connected with around certain shared interests and activities. We hang onto relationships with people who do not align with what we want for ourselves. We changed, or they have changed and sometimes so does the nature and quality of the relationship with them. Whether you want more from life or your worldview has evolved, you may be faced with outgrowing some of the things and people around you.
Some time ago, a friend of mine admitted that she was bothered by my suggestion that she had perhaps outgrown her boyfriend at the time. In her mind, acknowledging that she may have outgrown him was arrogant and selfish.
I realized then that is part of the mistake a lot of people make. It is why we stay in unfulfilling and unbalanced relationships and friendships. I explained that recognizing that perhaps you have outgrown someone does not mean that you are an arrogant person who thinks you are better than another. Just like we would do with a pair of pants or a shirt that became too tight, too big or too short, sometimes, we have to find a different size.
Growth and change are a part of life's journey. Sometimes our relationship to people, places, and things change and these are no longer a good fit for us. Growth and change nudges us along life's paths and if we are alert enough to what is happening and open enough to the many wonderful possibilities that could result, we figure out ways to adjust, adapt, and embrace the process.
Be encouraged.
Contact columnist LaTonya Dunn at email@example.com.
More like this story
- Warning light no time to trade in ( November 15, 2010 )
- Experiences and imperfections help to create who we are ( August 22, 2011 )
- Look forward to what's next in life ( July 25, 2011 )
- Resisting change can hinder your progress ( March 25, 2013 )
- To err is human; accept it ( April 8, 2013 )


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The KBC Team Tournament is Cancled. Courts will be available as usual this weekend.
KBC bids a fond farewell to Ron Kelly, who has been forced to give up badminton due to illness. Ron served as both treasurer and president at KBC. In thanks for his many years of service, KBC provided Ron with this wildlife print (print by John Whitall).
Workmen will be repairing and cleaning the court heaters all day on Friday Nov 7. This will require closing individual courts for brief periods of times. Play can continue, but not all courts will be available at all times.
Tess Tearoe has stepped down after two and a half years as Membership Director. KBC would like to thank Tess for all her hard work over this time.
We are pleased to announce that Mark Kayban has accepted the role as the new Membership Director.
Attention Badminton Players, the Canada Winter Games is looking for Badminton Volunteers. Badminton will be taking place from February 22-28, 2015 at the Charles Jago Northern Sport Centre in Prince George, BC.
A Volunteer Road Trip bus is being arranged to transport volunteers to and from Prince George, as well as provide billeting for those in need of accommodations. Get a front row seat to some of the best badminton in Canada.
Due to under enrollment, the Kelowna Open has been cancelled. All courts will be available as usual this weekend.
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Today we're bringing you the incredibly talented illustration duo all the way from Barcelona, Brosmind. Continue reading →
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Specializing in Bottles, Food, Flowers, Illustrations, Product, Liquids Mike Wepplo has work for numerous agencies across the USA combining a mixture of illustration and photography. Continue reading →
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Increasingly within the industry packaging visualisers are becoming more common place, sometimes said visualisers rely heavily on a 3D based skill set and other times they rely heavily Continue reading →
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There is the notion here that real Portlanders do not use umbrellas. Really? We're stupid enough or silly enough to get drenched in a downpour?
—Kevin S.
What is a "real Portlander," anyway? I thought all the real Portlanders moved away in 1995 to escape the Californians. (Luckily, they left behind plenty of lumberjack clothes to keep the hipsters warm on their collective daily trek from the Prius to the Stumptown counter.)
More saliently—what downpour? Not to go all old-man on you (he said, lying), but in my Illinois youth we had real rain. I'm pretty sure I walked 20 miles to school each day through chest-deep flash floods, naked, with rabid crayfish dangling by their claws from my nut sack. (And I was glad!)
That's the kind of rain you need an umbrella for. In Portland, we don't use umbrellas because…it doesn't rain that much here.
Now, now; put away those pitchforks. Sure, it rains often, and it rains for a long time. It just doesn't rain that much. Portland isn't even in the top 15 major U.S. cities in annual rainfall.
We are No. 1 in rainy (as distinct from snowy) days, with around 165 per year—we even beat Seattle! But due to the fact that our precipitation is not so much rain as an extremely dickish form of fog, you never get the kind of wring-out-your-briefs wet that makes you shake your tiny fist at the sky and vow, "Never again."
Add to that the fact that if you did carry an umbrella, you'd have to carry it all the time, and you can see why for most Portlanders it hardly seems worth the trouble.
All of this does nothing to mitigate the soul-crushing, Kafkaesque oppressiveness of five straight months without sun, of course, but an umbrella won't help with that. Might I recommend a flask?
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Motherless Brooklyn (1999)
by Jonathan Lethem
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Motherless Brooklyn is the first of Lethem's more well-known novels, and so I was expecting to really like it, particularly after Girl in Landscape left me cold. It follows native Brooklynite Lionel Essrog, who is recruited in childhood along with a few friends from an orphanage (hence the title) by local small-time crook Frank Minna, to be groomed as what Minna styles "private detectives," but who are actually just goons, thugs, or whatever you'd like to call them. In the novel's opening scene, Frank is killed, and Motherless Brooklyn revolves around Lionel's quest to solve the mystery of his father-figure's murder.
Lionel also has Tourette's syndrome (much less well-known when the novel was written), and his investigative interviews are hampered by his constant outbursts of verbal nonsense. There's probably a postmodern reason for this, something to do with investigations, truth, the way our minds tick, etc. But I was never engaged with the novel enough to care. The plot itself is stock-standard crime novel stuff, complete with Japanese mobsters, Brooklyn thugs and an antagonistic homicide detective – although I did like the idea of telling a story from the point of view of one of a mobster's anonymous thugs, the guys who always lurk menacingly in the background, whom we never think of having their own lives or stories.
Overall I didn't particularly enjoy Motherless Brooklyn, and if I had to pick one I'd still say Lethem's best book is As She Climbed Across The Table, although that wasn't what I'd describe as a great novel. I've read Lethem's first five novels now, and find him to be a frustrating writer – always on the verge of writing something really great, but never quite getting there. Hopefully his next book, Fortress of Solitude, will finally do it.
Original post at Book Rhapsody.
A De-tec-tic Tale
I am not a fan of detective novels. I am not a fan of a lot of things, if you have noticed through the constant reading of what I write. But I did like watching that Japanese cartoon detective series aired a few years ago on local TV. Detective Conan, yes, that mysteriously shrunken cute boy genius who could solve any crime presented to him thanks to the innumerable convolutions of his brains.
And do detective stories always feature a super intelligent detective? No, I suppose. It's my first time to read a book explicitly described as a detective tale, so I was expecting the protagonist to have some qualities of the detective cliché: trench coat and fedora, an air of mystery, grave and somber personality, vast knowledge on everything, and a weapon hidden beneath the clothes.
But what we have here is a human freakshow. That's what our detective Lionel Essrog is called. He is our protagonist, and instead of inheriting at least one quality from any detective, he instead is afflicted with Tourette's Syndrome.
And what is that?
Is guilt a species of Tourette's? Maybe. It has a touchy quality, I think, a hint of sweaty fingers. Guilt wants to cover all the bases, be everywhere at once, reach into the past to tweak, neaten, and repair. Guilt like Tourettic utterance flows uselessly, inelegantly from one helpless human to another, contemptuous of perimeters, doomed to be mistaken or refused on delivery.
Guilt, like Tourette's, tries again, learns nothing.
And the guilty soul, like the Tourettic, wears a kind of clown face–the Smokey Robinson kind, with tear tracks underneath.
Simply put, Tourette's is a set of compulsive behaviors that includes obsessing with repeating tasks and gestures (tapping people's shoulders), obsessing with counting objects and actions (tapping people's shoulders four times), and obsessing with wordplay (tapping people, tack it simple). So yes, a Tourettic is an unbeatable wordsmith. He can hammer the phrase "happy together" to "crappy however" and "slappy forget her." Take note that such a wordplay uncontrollably comes off as a tic, and since the novel is told in the point of view of Essrog, this makes the narrative wild and witty.
Anyway, the novel is set in Brooklyn. Lionel Essrog (Unreliable Chessgrub!), an orphan, was brought under the care of Frank Minna along with three other boys from the same orphanage. The four boys were first hired to do various chores that teenagers can perform, such as carrying crates from a truck to a warehouse, since Frank Minna is running a moving business. This evolved into a car service. Then it became a detective agency, which is not really a detective agency but something else under the guise of a car service.
One afternoon, Frank Minna is murdered. The four boys, being quasi, pseudo detectives, set out to find out what happened. So there's the, I think, usual clue-finding, suspects, badass men, giant men, old men, conspiracies, generalizations, realizations, and voilà! Case solved.
I think that this is more a psychological case study than a mere crime-detective novel. It is very interesting to see Lionel deal with his Tourette's while attempting to solve a murder mystery. During his investigations and interrogations, he would tic like crazy, usually favoring "eatmeBailey!" among his set of tic words. Who this Bailey is, we don't know. If he is someone from Lionel's murky past, we are never told. Or it could be that Bailey is just a fictional friend as Tourette's is his Siamese twin.
It is this Tourette's thing that made me so immersed in my reading of this novel. Lionel's babbling could make the reader literally laugh out loud. But it is just not a laughing matter. Lionel's Tourette's is also a metaphor for a lot of things. The genre of the novel where Lionel moves is very much like his Tourette's: a struggle to cast off the internal turbulence roiling underneath. It can be also that it is a microcosm of society's attempt to deal with helplessness and its compulsion to perform its antics.
The last chapter of the novel may have playfully skirted around too much sentimentality, but that doesn't make Lionel less of a memorable narrator. After finishing this, I felt that the novel is underrated, that it should be given more than what it's credited for, regardless of notions of gimmick.
And let me tell you something. While I was reading this novel, I felt like laughing at myself because I see some of Lionel's behavior in my mind's eye being perfectly acted by myself. Maybe I am mildly Tourettic? And so what? I know one bookish friend who's singing "All the Pretty Horses" to the tune of "Single Ladies."
Viable guessfrog! Barnamum Pierogi! Garden State Bricco and Stuckface! Pianoctamus! Pianoctamum Bailey!
The plot's a little random, but the book is a joy to read.
This book was just ok, not a bad story but could be confusing at times. I read this for bookclub and some of our members couldn't get past the bad language as the main character in this book has tourette's. There were some laugh out loud moments when he was trying to get out a phrase and it came out this rhyming mess of made up words, but then you felt kind of bad you laughed. I think it may have been an insightful look into what it is like to have tourettes but as I've never met anyone with the disease I can't be sure.
Frank Muller did the narration and I am very glad I listened to this one because of Lionel's ticks and his rhyming sing-songy tourettes and Muller made these very believable, other members of my bookclub said it was hard for them to understand just how these were said in print, so if you are going to read this one I recommend the audio.
2 ½ stars
A witty, humorous mystery just shy of being insightful.
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Amazon.com Amazon.com Review (ISBN 0375724834, Paperback)Pop quiz. Please complete the following sentence: "There are days when I get up in the morning and stagger into the bathroom and begin running water and then I look up and I don't even recognize my own _." If you answered face, then your name is obviously not Jonathan Lethem. Instead of taking the easy out, the genre-busting novelist concludes this by-the-numbers string of words with toothbrush in the mirror.
This brilliant sentence and a lot of other really excellent ones compose Lethem's engaging fifth novel, Motherless Brooklyn. Lionel Essrog, a detective suffering from Tourette's syndrome, spins the narrative as he tracks down the killer of his boss, Frank Minna. Minna enlisted Lionel and his friends when they were teenagers living at Saint Vincent's Home for Boys, ostensibly to perform odd jobs (we're talking very odd) and over the years trained them to become a team of investigators. The Minna men face their most daunting case when they find their mentor in a Dumpster bleeding from stab wounds delivered by an assailant whose identity he refuses to reveal--even while he's dying on the way to the hospital.
Detectives? Brooklyn? Is this the same Lethem who danced the postapocalypso in Amnesia Moon? Incredibly, yes, and rarely has such a departure been pulled off with this much aplomb. As in the "toothbrush" passage above, Lethem sets himself up with the imposing task of making tired conventions new. Brooklyn accents? Fuggetaboutit. Lethem's dialogue is as light on its feet as a prize fighter. Lionel's Tourette's could have been an easy joke, but Lethem probes so convincingly into the disorder that you feel simultaneously rattled, sympathetic, and irritated by the guy. Sure, the story is a mystery, but Motherless Brooklyn could be about flower arranging, for all we care. What counts is Lionel's tic-ridden take on a world full of surprises, propelling this fiction forward at edgy, breakneck speed. --Ryan Boudinot
(retrieved from Amazon Thu, 12 Mar 2015 18:24:13 -0400)
Lionel Essrog has always respected Frank Minna, who helped him out when he was young, and when Frank is found dead, Lionel and his friends, the Minna Men, scour the streets of Brooklyn in search of the killer.
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Youth fishing championship site offering guidelines for the competitions, a background of the event, and photo galleries.
Explains how to convince children to enjoy the sport. Also includes articles, instructions, links to related sites, photos, and contact information.
Discusses guidelines, instructions, and tips for fly-fishing in Oregon. Also includes photos, articles, links to related sites, and contact information.


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Caring for animals could lead to positive traits in young adults
Young adults who care for an animal may have stronger social relationships and connection to their communities, according to a new study.
Paper's author, Megan Mueller, Ph.D., a developmental psychologist and research assistant professor at the Cummings School of Veterinary Medicine at Tufts University, said that the young adults who had strong attachment to pets reported feeling more connected to their communities and relationships.
Mueller surveyed more than 500 participants aged 18-26 and predominately female about their attitudes and interaction with animals. Those responses were indexed against responses the same participants had given on a range of questions that measure positive youth development characteristics such as competence, caring, confidence, connection, and character, as well as feelings of depression, as part of a national longitudinal study, the 4-H Study of Positive Youth Development, which was led by Tufts Professor of Child Development Richard Lerner, Ph.D., and funded by the National 4-H Council.
Young adults who cared for animals reported engaging in more "contribution" activities, such as providing service to their community, helping friends or family and demonstrating leadership, than those who did not.
The more actively they participated in the pet's care, the higher the contribution scores. The study also found that high levels of attachment to an animal in late adolescence and young adulthood were positively associated with feeling connected with other people, having empathy and feeling confident.
The paper has been published online in journal Applied Developmental Science.
(Posted on 02-02-2014)
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Patch 6.2.2a Hotfixes: October 8
Get the latest information on hotfixes addressing various issues on the live realms for World of Warcraft Patch 6.2.2.
Notes for Patch 6.2.2a
Notes for World of Warcraft Patch 6.2.2a to address a number of issues that required a client-side patch to fix.
Apexis Crystal Bonus Event October 7 – 13
This weekend, you'll gain bonus Apexis Crystals from eligible creatures.
2015 European Road to BlizzCon Highlights
The 2015 European Road to BlizzCon has come to an epic conclusion. Take a look at a brief recap of all the action that took place over the weekend!
In-Game Shop Expands
The in-game Shop has expanded to provide access to select paid character services, including Appearance, Faction, Name, and Race Changes*—all right from the comfort of the character-selection screen. Now you can change your allegiance, alter your identity, or make your character over to transform them into a better . . . them.
Don't Miss the European Road to BlizzCon this Weekend
The 2015 European Road to BlizzCon gets underway in Prague, Czech Republic this weekend, October 3-4, and it's going to be epic! If you're an eSports fan, you won't want to miss the Hearthstone, Heroes of the Storm, and World of Warcraft European Championships being held at the event.
This Month in WoW – October 2015
This year, we're spending the month of October celebrating brew, tricky treats, and PvP as we zero in on BlizzCon 2015.
Burning Crusade Timewalking Event: September 30 - October 5
Through Monday, October 5, players at level 71 and higher can (and should!) queue for Burning Crusade Timewalking Dungeons.
Activities and Entertainment at the 2015 European Road to BlizzCon
The 2015 European Road to BlizzCon heads to Prague, Czech Republic from October 3-4, and we've got plenty of activities and entertainment in store for visitors!
European Road to BlizzCon Cosplay Contest
From October 3-4, the 2015 European Road to BlizzCon is coming to the O2 Arena in Prague, Czech Republic, and eSports talents will not be the only ones present at the event!
Get Ready for the World of Warcraft European Championship
After some intense arena action in the 2015 World of Warcraft European Championship Qualifiers in August, eight teams have emerged victorious! They'll continue their quest for glory at the European Road to BlizzCon in Prague, Czech Republic from October 3-4.


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Update will not open
Asked on May 30, 2013 - 06:30 UTC
I downloaded the latest update for Windows and after the updage todoist will not open. I havge downloaded and intalled it several times. The same result each time. Windows XP operating system
All responses
Replied on May 30, 2013 - 12:25 UTC
Hello David,
Please clarify - you've downloaded our update of the Windows app or an update for the Windows system after which our app won't work?
Also, do you have the latest version of Microsoft .NET Framework 4 installed on your computer and what exactly happens when you try to open the app? Do you see any error messages?
Best regards,


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Subaru Repair in Iron Mountain
Our master mechanics identify the best Subaru repair shops in Iron Mountain. Edit search×
There are 36 Subaru service shops and mechanics in Iron Mountain. Edit search
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Subaru repair shops and dealerships near Iron Mountain.
1330 N. Stephenson, Iron Mtn.
"Very fast and efficient. Good prices on repairs."
801 Stephensen Ave, Escanaba
701 Carpenter Ave, Iron Mountain
Muffler & Exhaust, Roadside Assistance, Service & Repair, Tire Sales/Repair
826 Roberts Dr., Iron River
2226 6th Ave North, Escanaba
Service & Repair, Tire Sales/Repair
14409 State Hwy 32, Mountain
Collision Repair & Paint, Service & Repair
5076 Us 2 & 41, Escanaba
750 Coolidge Avenue, Niagara
1228 Prospect Ave, Iron Mountain
93 North Pine, Gwinn
325 W Iron Street, Gwinn
600 East Pioneer, Crandon
500 W. Iron River, Iron River
301 Carpenter Ave, Iron Mountain
Service & Repair, Tire Sales/Repair
1225 Roosevelt Rd., Niagara
Muffler & Exhaust, Service & Repair
99 E. M35, Gwinn
"wow, I have heard too many HORROR stories about this company! Recently ripped of my GF, tried to steal her car! AVOID..."
1402 Ludington St., Escanaba
Roadside Assistance, Service & Repair
411 Carpenter Avenue, Iron Mountain
W7600 Us Highway 2, Quinnesec
AC/Heating, Alignment, Check Engine Light, Classic Car Repair/Restoration, Collision Repair & Paint, Diagnosis, Muffler & Exhaust, Oil Change & Lube, Scheduled Maintenance, Service & Repair, Smog/Emissions Testing, Timing Belts, Tire Sales/Repair, Transmission Repair, Windshield/Glass
3461 US Hwy. 2, Florence
AC/Heating, Check Engine Light, Diagnosis, Hybrid/Electric, Muffler & Exhaust, Oil Change & Lube, Roadside Assistance, Scheduled Maintenance, Service & Repair, Timing Belts, Tire Sales/Repair
1270 County Road B, Niagara
2300 Ludington St, Escanaba
135 Zavada Dr, Crystal Falls
329 Washington Ave, Iron River
628 Stephenson Ave, Escanaba
4004 E. Maple Ridge, Rock
5531 US-41, Champion
15242 Brooklane, Lakewood
407 North Stephenson Avenue, Iron Mountain
5937 Valley Lane, Crandon
2511 Ludington Street, Escanaba
701 S Stephenson Ave, Iron Mountain
W5454 E 3rd Street, Hermansville
"shoddy workmanship, don't stand behind their repairs. Won't do one bit more than paid for including looking to make ..."
2120 N Lincoln Rd, Escanaba
2303 9th Ave. N., Escanaba
1800 S Stephenson Ave, Iron Mountain
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Yahoo's Dan Boberg Discusses Opening "Panama's" Search API
Yesterday Yahoo announced they are opening up the API to their new search platform (aka "Panama").
The Yahoo paid search API allows programmers to write code to interact with Yahoo's ad platform programatically. Yahoo's former paid search API ("DTC-XML") was available only to large agencies and advertisers and could involve fees.
In contrast, Yahoo is providing the new Panama paid search API to everyone, and is not charging access fees.
I caught up with Dan Boberg, Yahoo's Managing Director of Sales Technology, by phone yesterday to talk about this API announcement.
Dan Boberg, Yahoo's Managing Director of Sales Technology
APRK: Hi Dan. Tell us about opening up the Yahoo paid search API.
DB: Sure. We're really pleased about this new API as it is really important to Yahoo to provide access to our platform to all advertisers out there. Small businesses, medium businesses, all the way up to enterprise clients, agencies, analytics providers, everyone. Our goal is making Yahoo more transparent and open. And this API is robust: through the API advertisers can use every feature of the Yahoo platform.
We're are providing this access for free. We are not charging for quota — capacity will be given for free. More capacity than most advertisers will need, in fact. Advertisers who want higher levels of support can pay for that.
At the bottom, you have the platform itself. The new platform is robust, scalable, and fully-featured. On top of that platform, we've added a commitment to openness. The API is part of that commitment on Yahoo's part to transparency and access. And of top of that, we are adding professional grade support — service level agreements, more technical support, collaboration on our product road map, professional services — for those advertisers and agencies who want that.
Search is a multi-billion dollar business. Yahoo has always had search APIs — we launched the first search API in the industry in 2001. This new platform, this new API, and the professional grade support are about taking Yahoo search from the 1.0 to the 2.0 world.
APRK: You've announced three levels of support — "basic", "advanced", and "elite". Can you tell us more about those levels? Are these levels just about support, or will "advanced" and "elite" advertisers receive better access to the platform, say, more functionality, higher quotas, faster servers, whatever?
DB: These levels are about support and dedicated resources and service level agreements, not access. All advertisers, regardless of level, will have access to the same platform and the same functionality.
For "advanced" support, we are not charging all that much, $2000 per month. This level provides our partners with more support, more dedicated Yahoo engineering resources should they need support. At the advanced and elite levels, we'll make specific commitments regarding uptime, and provide our partners with in our product roadmap process.
We don't provide a specific price for the "elite" support, as it varies by case, and can even involve us putting Yahoo engineers on site.
APRK: Google has taken a different approach. They don't charge for support, but rather charge a nominal fee for each API action, 25c per thousand API tokens.
DB: We're interested in best serving our advertisers, and we differentiate from our competition when it makes sense.
Our objective is to make capacity a non-issue. We've spent considerable time building a robust scalable platform.
We've also spent decent time writing robust documentation and SDKs, with more to come, for smaller developers, and advertisers who want to do it themselves.
We think all advertisers will find this new API easy to use. And for those companies wanting higher level of service, visits from Yahoo engineers, and so on, they can get that as well.
APRK: Thanks for taking the time today, Dan. Good luck with the new program.
What This Means To Advertisers
Eventually, higher CPCs on Yahoo, surely. That would have happened anyway; the API simply accelerates the process.
While major agencies and advertisers (like RKG, for example) have been using this API since it beta'd last fall, this announcement will allow many more advertisers to interact with Yahoo programatically. In turn, this will make the Yahoo search marketplace more efficient, in the economic sense, leading to higher CPCs for Yahoo.
Opening up the Yahoo API will also foster innovation.
APIs let developers "mash up" applications in interesting ways. For example, Google's API allowed them to collaborate with Intuit, integrating AdWords with QuickBooks.
One would think that application developers who have already integrated Google Adwords into their apps would use Yahoo's new open API to "snap in" Yahoo functionality, too.
While that may be technically easy, Google's API T&Cs forbid developers from placing other search platforms on an equal footing with Google, prohibiting a lowest-common-denominator approach.
It will be interesting to see if Google chooses to enforce these provisions hinder developers from collaborating with Yahoo.
What This Means To Wall Street
While an open API will do little to decrease the gap between Yahoo and Google in search share, opening up the Panama API is totally the right move from Yahoo's perspective.
Right move, right direction, little immediate impact.
Random API Gossip From RKG Engineers
By coincidence, earlier this week, unsolicited and unrelated to Yahoo's announcement yesterday, the following comments floated up from RKG's Engineering Catacombs about the various APIs. Didn't warrant their own post, but since this post is about APIs, tacking those on here.
* Google API: Fast, full-featured, well-considered. Much unexplained downtown, much more than Yahoo.
* Yahoo API: Slow. Operations time out. Good docs. Reliable, high uptime.
* Microsoft API: Fast (perhaps because so few are using it?). Fails hard, without error messages. Fails often.
* Ask API: Scarily insecure. (SQL injection, anyone?)


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- Northern New York Newspapers
- Watertown
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The Jefferson County Sheriffs Department will host a free Operation Safe Child event from 11 a.m. to 3 p.m. today in center court of Salmon Run Mall, 21182 Salmon Run Mall Loop West.
The event is being held to issue child identification fingerprint cards to all children who are accompanied by an adult.
Thousands of readers like you have made Northern New York Newspapers the number one ranked website* for local news and sports coverage in the north country.
You can continue on to this article in a few seconds, or you can visit one of our websites:


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|News » Archives
Related Links
Monday, August 13, 2012
NASHVILLE, Tenn. – Where else but No. 3? The Lipscomb volleyball team blistered rival Belmont 3-0 (25-14, 25-19, 25-15) to earn the third-straight Atlantic Sun Conference Tournament championship after having to split the regular season title with the Bruins.
The win punched the Lady Bisons ticket to the NCAA Tournament where Lipscomb faced off against Texas A&M in College Station, Texas.
Senior Katie Rose earned A-Sun Tournament MVP honors and was joined on the All-Tournament team by then freshman Lauren Ford and fellow senior Abbey Fay.


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President Obama Nominates Sen. John Kerry To Be Secretary Of State
U.S. President Barack Obama chats with Sen. John Kerry while Vice... Fotografia de notíciasBarack Obama,Casa Branca - Washington DC,Condado de Kerry,Da cintura para cima,EUA,Falar,Governo,Horizontal,John Kerry,Joseph Biden,Ministro,Nomeado,Olhar,Política,Ponto Turístico Internacional,Presidente dos EUA,Vice-Presidente,Washington DCPhotographer PoolCollection: Getty Images News 2012 Getty ImagesWASHINGTON, DC - DECEMBER 21: (AFP OUT) U.S. President Barack Obama (L) chats with Sen. John Kerry (D-MA) (R) while Vice President Joe Biden looks on after Obama nominated Kerry to be the next Secretary of State in the Roosevelt Room of the White House December 21, 2012 in Washington, DC. If confirmed, Kerry will replace retiring Secretary of State Hillary Clinton early in 2013. (Photo by Jim Lo Scalzo-Pool/Getty Images)


text: More from SI Report: Dodgers release pitcher Freddy Garcia Report: Dodgers release pitcher Freddy Garcia Marshawn Lynch sports gold cleats for Super Bowl Marshawn Lynch sports gold cleats for Super Bowl Louisville vs. FIU: Game time, live stream, TV coverage Louisville vs. FIU: Game time, live stream, TV coverage Pittsburgh-area high school football player dies after... Pittsburgh-area high school football player dies after... Close Tweet0 Share0 Comment0 Share0 Share0 Stumble It0 Print0 More SI Wire Report: Arizona Cardinals considering trade for Raiders' Carson Palmer by Brian Kotloff Email Posted: Sat Mar. 30, 2013 Carson Palmer is set to make $13 million next season after posting an 85.3 quarterback rating in 2012. (Thearon W. Henderson/Getty Images)The Oakland Raiders' potential trade for Seahawks quarterback Matt Flynn could set the NFL quarterback carousel in motion.If Oakland finds its man in Flynn, the Arizona Cardinals could put together a deal for current Raiders QB Carson Palmer, azcentral.com's Kent Somers is reporting.Like the Flynn trade -- which the Seattle Times reported on Friday is close to occurring -- any trade for Palmer would only be completed if he restructures his contract to take a pay cut from the $13 million he is owed next season, according to Somers.The Cardinals would only agree to a trade if it costs them late-round draft picks, possibly conditional on how Palmer plays, Somers reports. They could also wait to see if the Raiders release him so they could simply sign him as a free agent.From Somers' report:Palmer could refuse and a proposed trade would be off. That would make sense from Palmer's perspective. It would force the Raiders to release him and Palmer would then be free to pick his next employer. He probably would prefer a team that appears closer to making the playoffs than the Cardinals.Palmer, 33, threw 22 touchdowns and 14 interceptions for the 4-12 Raiders last season. Arizona's current quarterback crop includes Drew Stanton, Ryan Lindley and John Skelton. Promoted Stories Comments


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The May 2011 Daring Bakers' challenge was hosted by Emma of CookCraftGrow and Jenny of Purple House Dirt. They chose to challenge everyone to make a Chocolate Marquise. The inspiration for this recipe comes from a dessert they prepared at a restaurant in Seattle.
When I first saw this recipe I was fairly frightened by it. It had so many components and it seemed quite challenging. To be completely honest, I was afraid it will turn into total disaster. But then I set down and read the recipe for couple of times. After carefully reading it I made an attack plan and decided to start this challenge early in the month, so if everything goes wrong I'd still have a chance to do it all over aging.
Recipe that was presented by Emma and Jen was very detailed and I had no difficulties following it, only problem was that it was calling for kitchen gadgets I didn't have – candy thermometer and a blowtorch. Well I wasn't about to let such a small details get in my way.
Finding a candy thermometer wasn't a problem, I simply borrowed it form a friend of mine. Blowtorch, on the other hand, was a completely different story. As it turns out blowtorch is very difficult to come by in Croatia. Well, I could've bought one but I wasn't ready to spend a small fortune on it and Amazon still doesn't deliver kitchen appliances to my country. So I had to be resourceful and decided to use plain kitchen lighter instead of a blowtorch. And guess what? It worked like a charm!
I decided to make only a quarter of the recipe as I wasn't sure how it will turn out. Since I was rather pleased with final result I think I'll be making the whole quantity next time. And there will be a next time for sure. :)
Mandatory parts of this challenge were chocolate marquise and meringue and everything else was optional so I experimented with spices and caramel. I added cinnamon, allspice and coriander to marquise and instead of tequila I used pear rakija. Rakija is a our local brandy which is very popular allover the Balkans. I don't really like to drink it, it's way to strong for my taste but it was interesting addition to marquise. Also, I made some candied kumquats and aceto balsamico sauce to accompany the dessert.
I had some trouble photographing my fished challenge, it's been really hot here these past few weeks and my marquis was melting rather quickly. Nevertheless dessert was delicious and I'm going to make it again for sure.
chocolate marquise
- In the bowl of a stand mixer, combine the egg yolks and whole eggs. Whip on high speed until very thick and pale, about 10 - 15 minutes.
- When the eggs are getting close to finishing, make a sugar syrup by combining the sugar and water in a small saucepan. Bring the syrup to a boil and then cook to softball stage (235F/115C). If you have a cake tester with a metal loop for a handle, the right stage for the syrup is reached when you can blow a bubble through the loop.
- With the mixer running on low speed, drizzle the sugar syrup into the fluffy eggs, trying to hit that magic spot between the mixing bowl and the whisk.
- When all of the syrup has been added (do it fairly quickly), turn the mixer back on high and whip until the bowl is cool to the touch. This will take at least 10 minutes.
- In a separate mixing bowl, whip the heavy cream to soft peaks. Set aside.
- When the egg mixture has cooled, add the chocolate base to the egg mixture and whisk to combine. Try to get it as consistent as possible without losing all of the air you've whipped into the eggs. We used the stand mixer for this, and it took about 1 minute.
- Fold 1/3 of the reserved whipped cream into the chocolate mixture to loosen it, and then fold in the remaining whipped cream.
- Pour into the prepared pans and cover with plastic wrap (directly touching the mixture so it doesn't allow in any air).
- Freeze until very firm, at least 2 - 4 hours (preferably 6 – 8 hours).
- When you're ready to plate, remove the marquise from the freezer at least 15 minutes before serving. While it's still hard, remove it from the pan by pulling on the parchment 'handles' or by flipping it over onto another piece of parchment.
- Cut it into cubes and roll the cubes in cocoa powder. These will start to melt almost immediately, so don't do this step until all of your other plating components (meringue, caramel, spiced nuts, cocoa nibs) are ready. The cubes need to sit in the fridge to slowly thaw so plating components can be done during that time. They don't need to be ready before the cubes are rolled in the cocoa powder.
- Plate with the torched meringue and drizzled caramel sauce, and toss spiced almonds and cocoa nibs around for garnish. You want to handle the cubes as little as possible because they get messy quickly and are difficult to move. However, you want to wait to serve them until they've softened completely.
chocolate base
- Place the chocolate in a small mixing bowl.
- In a double-boiler, warm the cream until it is hot to the touch (but is not boiling). Remove from the heat and pour over the chocolate.
- Allow it to sit for a minute or two before stirring. Stir until the chocolate is melted completely and is smooth throughout.
- Add the remaining ingredients and stir to combine.
- Set aside until cooled to room temperature. Do not refrigerate, as the base needs to be soft when added to the marquise mixture. If you make it the day before, you may need to warm it slightly. Whisk it until it is smooth again before using it in the marquise recipe.
torched meringue
- Combine the egg whites, sugar and vinegar in the bowl of a stand mixer. Using your (clean, washed) hand, reach in the bowl and stir the three together, making sure the sugar is moistened evenly by the egg whites and they make a homogeneous liquid.
- Over a saucepan of simmering water, warm the egg white mixture. Use one hand to stir the mixture continuously, feeling for grains of sugar in the egg whites. As the liquid heats up, the sugar will slowly dissolve and the egg whites will thicken. This step is complete when you don't feel any more sugar crystals in the liquid and it is uniformly warm, nearly hot.
- Remove the mixing bowl from the saucepan and return it to the stand mixer with the whisk attachment. Whisk until you reach soft peaks. In the last 10 seconds of mixing, add the vanilla to the meringue and mix thoroughly.
- When you're ready to plate the dessert, spoon the meringue onto a plate (or use a piping bag) and use a blowtorch to broil.
candied kumquats
- In a heavy saucepan, combine the water and sugar and bring to a boil over high heat. Add the kumquats, being careful not to overcrowd your pan.
- Reduce the heat to a simmer and let the fruit become translucent, about 20-30 minutes.
- Remove the fruit with a slotted spoon and place it, separating the slices, on a piece of parchment paper.
- Add orange juice to eltied sugar mixture and continue to simmer until tick sauce is formed.
- Chill kumquats and orange sauce and serve with marquise.
aceto balsamico sauce
- In a small sauce pan, combine sugar and aceto balsamico. Bring it to boil over medium heat.
- Turn down the heat and boil until aceto is reduced to thick sauce.
- Add chocolate and stir well to combine. Let it cool down at room temperature and then in the fridge.
- You can serve this sauce with all sorts of desserts.


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Hensley's Prairie Path Realty may be new to Villa Park, but the Hensley's are not.
Over the years they have been in Villa Park, they are known for their service to our community: Doc with the chamber and as Village Trustee and Tammy as the former cable commission member and former community pride commission member. For nineteen years they provided courteous and knowledgeable service to their customers at Doc Hensley's Antiques and Repair Store in Villa Park, Illinois.
Welcome to Hensley Prairie Path Realty, your #1 source when it comes to Villa Park, IL Real Estate and Homes for Rent in DuPage County. Have you been searching for quality homes for sale? Villa Park, Illinois has some of the finest residential property available, and you can find out all you need to know about these Villa Park or DuPage County homes for sale when you get in contact with the agents at Hensley Prairie Path Realty. The owners, Doc and Tammy Hensley, have been active in the Villa Park community for over 19 years and although they may be new to the Villa Park, IL Real Estate business, they are very familiar with the area and are highly qualified to assist you with all of your Villa Park, IL Real Estate needs. Along with their helpful staff of Villa Park Realtors, Star Southworth, Melanie McGinnis and Rosie Ramirez-Espinosa who is fluent in both English and Spanish, The Hensley's can help you browse through all of the Homes for Sale in Villa Park, Illinois as well as in other towns such as Elmhurst, Lombard and Addison.
No matter if you are considering purchasing a new home or simply looking for houses for rent in Villa Park, Illinois, the helpful realtors at Hensley Prairie Path Realty can help you find the right home for you and your family. Each realtor that works for this agency are qualified CDPE, also known as a Certified Distressed Property Expert. This means that they can also help you with finding a low cost place of residence such as DuPage County Foreclosures for example. They may also be able to help families find a temporary place to live by looking through the available homes for rent in DuPage County. So you are not only dealing with some of the best Villa Park realtors when you work with this particular agency, but you are also working with well-informed DuPage County Realtors also and DuPage County short sale sellers.
Take a few moments to look around the informative website. You will find testimonials and helpful resources that can assist you with getting started in the home buying or selling process. Individuals who wish to search and subscribe to various MLS listings are able to do so, free of charge on the website. Customers can also contact any of the realtors at the agency for more information about any of the Villa Park, IL homes for sale listings that they like by using the contact information that can be found in the 'Contact Us' section. Once you are able to find several listings of houses for sale, Villa Park, Illinois' newest hometown realty company will be able to help you choose which the best is for you and your budget.
Hensley Prairie Path Realty can also assist their customers with listing homes for sale. Villa Park, Illinois is an ideal place to live and there's always someone looking for new residential property in the area. So no matter if you are moving in from out of state, or moving to Villa Park from a neighboring community, you will be sure to find the right place of residence for rent or purchase when you choose to do business with Doc and Tammy Hensley as well as their other agents on staff.


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The Hidden Knowledge Of Receiving The Ideal Deal F
Forums home -> Resumes -> The Hidden Knowledge Of Receiving The Ideal Deal F
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By mile1card on Aug 21, 2013 06:23 AM
A obstacle in the style of scientific trials is the want to show evidence of system in people in an acceptable dose variety, therefore deciding on the most suitable compounds for even more advancement.The clinical doses for SB-656933 have been chosen by linking inhibition of agonistinduced CD11b expression on peripheral blood cells to inhibition of airway neutrophilia in pre-clinical species,and hence demonstrating an acceptable therapeutic index. The CD11b assay was also executed in the one dose escalation research in healthier subjects introduced right here, comparable to the strategy used in the
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tests of other chemokine antagonists . SB-656933 was then assessed in an ozone challenge product, where solitary doses of SB-656933 resulted in a dose-dependent inhibition of ozone-induced airways neutrophilia at a magnitude predicted by the ex vivo CD11b information. These final results show how bridging amongst pre-medical species and human beings is essential for simplifying early scientific growth of novel therapies. The PK/PD modelling of the FTIH information efficiently educated dose variety of the ozone-obstacle research with self-confidence. The gain of employing a design-based mostly PK/PD investigation,particularly employing a mechanistic populace method to assess CD11b expression, was that all information have been combined and integrated in the
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product, delivering a a lot more sturdy and specific interpolation and extrapolation across the dose assortment instead than making use of the uncooked knowledge in isolation. This was specifically useful with the sort of crossover research executed for the FTIH review, in which the same topics acquired diverse treatments on a number of instances, and in which pharmacodynamic measurements at reduced doses ended up variable.1 limitation of the ozone problem review was that pharmacokinetic parameters could not be established by inhabitants evaluation owing to limited sampling, as a result precluding evaluation of a definitive PK–PD connection. In both reports, SB-656933 was nicely-tolerated. The noticed drop in neutrophil counts following the greater doses of SB-656933 in the FTIH examine need to be assumed to be induced by the drug till confirmed in any other case, since of the connection with size of dose and the time program of restoration after dosing. The reduction in neutrophils is not likely to have been because of to bone marrow suppression. Even though experienced neutrophils are not long-lived, they are not so evanescent that cessation of selleckchem pop over to this website
manufacturing would result in their circulating numbers to tumble by fifty% inside of 12 h of drug administration. A a lot more probably rationalization is that SB-656933 triggered a shift in distribution of neutrophils from the circulating pool to the marginated pool. Substantial and much more prolonged reductions in peripheral blood neutrophils had been witnessed with other CXCR1/CXCR2 antagonists with activity in the ozone challenge product. Initially, it was not clear whether or not this reduction in blood neutrophils was essential or contributed to the pharmacological impact. Our personal knowledge demonstrating a reduction in blood neutrophils at doses of 400 mg and earlier mentioned, led us in direction of investigating reduce doses of SB-656933 in the ozone challenge examine. In addition, the PK/PD modelling results showed that doses under four hundred mg would be sufficient to attain the concentrate on pharmacology selection knowledgeable by rodent versions. The benefits of the present review obviously display that a reduction in peripheral blood neutrophils is not a requirement for inhibiting airway neutrophilia beneath challenge circumstances for this mechanism.
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Meet Ray Kirkup, minibus driver at Cragside
- Name:
- Ray Kirkup
- Job:
- Minibus driver
- Location:
- Cragside, Northumberland
Ray is a retired police officer, having spent 30 years in service mostly as an advanced driver on motor patrol.
Ray first fell in love with Cragside while attending an accident near its entrance and now uses his skills to drive the estate's minibus and safely guide visitors around the site.
Ray says: 'It was a natural progression working for the National Trust, interacting with the public in such a beautiful environment.'
Best part of the job?
'Meeting the visitors and making sure they have an enjoyable time at Cragside. I work so hard the visitors are surprised I'm the only minibus driver on the estate.'
Favourite moment on camera for Inside the National Trust?
'Whilst taking the local community of senior citizens around Cragside, one of my passengers stole my thunder and gave a description of how as a young man he stripped the thatch roof from the Boat House of Blackburn. It was very amusing and interesting.'


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4.5 out of 5
Assistant Professor, Orthopaedics
Center for Integrative Medicine
New Patient Appointments: 336-716-WAKE Returning Patient Appointments: 336-713-2121Department: 336-716-8200
Insurance Accepted »
Assistant Professor, Orthopaedics
Center for Integrative Medicine
Academic: 336-716-0571 | Department: 336-716-8200
For a listing of recent publications, refer to PubMed, a service provided by the National Library of Medicine.
For a list of earlier publications, visit the Carpenter Library Publication Search.
Assistant Professor, Orthopaedics
Assistant Professor, Orthopaedics
Center for Integrative Medicine
4.5 out of 5
The overall Patient Rating score is the average of responses to the nine questions listed below. The questions are from the Press Ganey Patient Satisfaction Survey. Responses are measured on a 1 to 5 scale, where 1 represents "very poor" and 5 represents "very good."
Comments are taken from the Care Provider section of the Press Ganey Patient Satisfaction Survey. Comments are posted exactly as they are written. Comments are added weekly. To protect patient privacy and confidentiality, patient names are not included.
after the second visit i do not plan to see this provider again.
The doctor provided very limited communication... somewhat arrogant and condescending.
Dr. O'Gara is outstanding in his dealings with patients.
I have not had any bad experiences at any of the offices that I have been at...always courteous when making an appointment also. Very helpful
I was in extreme pain and the surgery took care of it
This Dr acted like I was a bother to him. He walks in the room and addressed me but couldn't acknowledge my parent in any way! It's rude and unprofessional!
Gave me good advice about the need for therapy which I am using with positive results.
I have great confidence in Dr. O'Gara.
Dr. Ogara was, without a doubt, the best Physician I have ever met. He was very honest and genuine and cared about why I was in to see him.
MD was so very helpful. explained different options for me.
Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.


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Customers are going wild over cats bred in Ponca City
No permit neededStates differ on what animals they allow residents to have as pets. In Oklahoma, only wildlife native to the state require a permit if they are kept as a pet, so Savannah owners have no licensing requirements beyond those for a domestic cat. A1 Savannahs is licensed by the United States Department of Agriculture. Random inspections of the facility have turned up no violations, according to the agency. Kathrin Stucki said some people may question whether the animals are dangerous or criticize them as a "designer breed." The cross does occur in nature, although rarely, she said. The Stuckis don't use artificial insemination or hormones to facilitate breeding between the cats. Instead, they pair two they think will make a good match in a cage and see what happens. The servals are especially picky, and sometimes it takes a few tries to find them a suitable mate, Kathrin Stucki said. Though visitors to the farm are warned of the dangers of the animals, and asked to sign a waiver, Martin Stucki said he hasn't been scratched. The Stuckis, who emigrated from Switzerland six years ago to run the cattery, pride themselves on their animals. "People think 'Oh my God, a kitty mill.' But we're different," said Kathrin Stucki. Though there are other Savannah breeders, including at least one other in Oklahoma, the Stuckis' facility boasts the widest gene pool in the world, she said. And they guarantee socialization with other animals as well as children. "We don't have another job. We spend all day with the cats," Kathrin Stucki said. But she wouldn't have it any other way. Stucki, who obtained a visa for extraordinary ability for her knowledge of animal breeding and is working on a veterinary medicine degree, recalled laughing when her husband recently bought a lottery ticket. "What would we do if we won?" she asked him. "I wouldn't do anything differently."


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Botulinum A Toxin in Patients With Parkinson's Disease (Botox-PD)
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The researchers investigated the effectiveness and safety of BoNT/A injected into the detrusor muscle in patients with PD and MSA all of whom had detrusor muscle overactivity unresponsive to conventional medical therapy.
Parkinson's Disease
Multiple System Atrophy
Detrusor Overactivity
Drug: Intravesical injection of Botulinum A toxin
Phase 4
|Study Type:
|Study Design:
|Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|The Use of Toxin Botulinum A Toxin in Patients With Parkinson's Disease and Multiple System Disease, Affected by Refractory Detrusor Overactivity.
- As primary outcome measures, patients attended for clinical evaluation (daily voiding diary an QoL questionnaire). [ Time Frame: One, three and five months after intravesical treatment ] [ Designated as safety issue: Yes ]
- Urodynamic assessment, and samples were obtained for urinalysis and culture. [ Time Frame: One, three and five months follow up ] [ Designated as safety issue: Yes ]
|Estimated Enrollment:
|Study Start Date:
|June 2008
|Estimated Study Completion Date:
|December 2009
|Estimated Primary Completion Date:
|December 2008 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Botulinum A toxin
Botulinum A toxin intravesical injection
Drug: Intravesical injection of Botulinum A toxin
One treatment, 200 U vials diluted in 20 ml normal saline
Other Name: Allergan
Detailed Description:
Patients included will have overactive bladder symptoms refractory to medical therapy. Other causes of overactive bladder symptoms including urogenital prolapse and recurrent urinary tract infections were excluded. None of the patients will be under anticoagulant therapy or drugs interfering with neuromuscular transmission. The study was approved by the local ethical committee and patients gave their informed consent. Patients will be informed about the possible need for intermittent catheterization after BoNT/A treatment.
As outcome measures we assessed clinical and urodynamic variables.
|Ages Eligible for Study:
|18 Years to 80 Years
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Patients with overactive bladder symptoms refractory to medical therapy.
Exclusion Criteria:
- Other causes of overactive bladder symptoms including urogenital prolapse and recurrent urinary tract infections were excluded.
- Concomitant anticoagulant therapy or drugs interfering with neuromuscular transmission.
- Neuromuscular disease like Lambert-Eaton syndrome.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00822913
|Principal Investigator:
|Antonella Giannantoni, M.D.
|University Of Perugia
No publications provided
|Responsible Party:
|Giannantoni Antonella, University of Perugia
|ClinicalTrials.gov Identifier:
|NCT00822913 History of Changes
|Other Study ID Numbers:
|Study First Received:
|January 14, 2009
|Last Updated:
|January 14, 2009
|Health Authority:
|Italy: The Italian Medicines Agency
Keywords provided by University Of Perugia:
Botulinum A toxin
Parkinson's disease
Additional relevant MeSH terms:
Multiple System Atrophy
Parkinson Disease
Shy-Drager Syndrome
Autonomic Nervous System Diseases
Basal Ganglia Diseases
Brain Diseases
Cardiovascular Diseases
Central Nervous System Diseases
Movement Disorders
Nervous System Diseases
Neurodegenerative Diseases
Parkinsonian Disorders
Primary Dysautonomias
Vascular Diseases
Botulinum Toxins, Type A
Neuromuscular Agents
Peripheral Nervous System Agents
Pharmacologic Actions
Physiological Effects of Drugs
ClinicalTrials.gov processed this record on October 02, 2015


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Grab some special savings on restaurants you love at Restaurant.com! Snag your favorite restaurants before they are gone. There is only a limited number of each restaurant available. Using the coupon code "ENTREE", you can get a $25 gift certificate for only $2! That's 80% off the regular price.
Restaurant.com is a great way to try new restaurants and save on a night out. Certificates are good for 1 year and some restrictions apply. Certificates work similar to coupons. Typically, to use a $25 certificate, you have to spend $35. Still, it's a bargain! With the 80% off code, you can end up paying as little as $12 for a $35 meal. That's 66% savings!
Read the small print when selecting your certificates to understand restrictions and requirements for use. Enjoy!
Hurry, offer ends 11/16/09!


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- Diamond Knife Sharpener, Table TopDiamond Knife Sharpener,Table Top
- Item # 2EVD7
- Mfr. Model # 22-41847
Knife Sharpener, Table Top, 8 Diamond Fingers Abrasive, Fine Grit, Grit Type Fine, Size 3 1/2 x 4 x 1 In,...More
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Built with safety in mind, this Sonic Glitz kids' bike makes a fabulous first ride for little ones. The bike is fitted with a robust 8 inch steel frame, rigid steel fork and 12 inch wheels. Kids can enjoy a safe and smooth ride thanks to front and rear caliper brakes and stabilisers, which can be easily removed as your child's confidence grows. To keep your child comfortable you can easily adjust both the handlebars and padded saddle to suit their individual size. A rear dolly carrier allows your child to take their favourite doll with them as they ride, while the fun handlebar streamers add a little extra sparkle to every journey.
Catalogue Number: 211-4441
- Great first bike for girls, with detachable stabilisers
- Chain guard for added safety
- Recommended for 3-5yrs, recommended height 98-112cm
Buy on Tesco Direct from:
Earn 75 Clubcard points


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Sunset Elk 4/4S Case
Show off your signature style with an ultra-tailored Speck Products by Hot Buckles™!
Combining luxury with uncompromised protection, this sleek hard plastic case is covered with an easy-to-grip that is richly printed with your favorite design. The first of its kind to be offered anywhere, this lightweight and durable Sunset Elk 4/4S Case allows optimal access to all sensors, ports, and controls on your iPad, while offering superior comfort in-hand.
- Sprint, Verizon or AT&T iPhone 4/4S Case
- Material: Plastic, Metal
- Size: 4.5" x 2.25"
- Weight: 0.3 oz
- Case Color: Black & White
- Allows access to all ports and buttons in the iPhone 4/4S
Note: it may take 1-3 business days to make this iPhone 4 Case.
There will be no returns accepted on an iPhone 4 Case!
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World's Largest Aftermarket Motorcycle Parts and Accessories Superstore!
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Fitment Note: Fits 1" engine guards only.
Clamps: With Clamps
Design: Anti Rotation
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Material: Die-Cast
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Style: Rail
With Mounts: Yes
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With the West Lites Series set to resume next month, Troy Lee Designs/Lucas Oil Honda's Cole Seely, who is third in points, 15 behind leader Dean Wilson, has changed his focus back to the Lites class after filling in for the injured Trey Canard on the Honda Muscle Milk Racing team in the Supercross (450cc) class the past few weeks. Canard's bike will now be ridden by GEICO Honda's Wil Hahn, who is returning from injury.
Wil Hahn will replace Cole Seely on Trey Canard's Muscle Milk Honda.
Hahn won his heat race and finished eighth in the main in the opening round of the2012 West Lites Championship at Anaheim before sustaining a broken hip while training the following week.
"Wil has shown considerable speed in the last few years in the Lites class, and we believe he has what it takes to run in the Supercross class," said Team Honda Muscle Milk Manager Erik Kehoe. "His focus and determination makes him a good fit for the team. I would like to thank everyone at GEICO Honda and all their sponsors for allowing Wil the opportunity to race a factory Honda in the Supercross class."
Hahn will make his debut on the Muscle Milk Honda this weekend at the Toronto Supercross.
Kit Palmer | Off-Road Editor
Kit Palmer started his career at Cycle News in 1984 and he's been testing dirt and streetbikes every since – plus covering any event that uses some form of a knobby tire. He's also our resident motorcycle mileage man with a commute of 120 miles a day.


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Melissa + Campana
'Campana Fitas' ballerinas
Out of stock
Unfortunately this item is out of stock
Gold-tone 'Campana Fitas' ballerinas from Melissa + Campana featuring a round toe, an intersecting rosette design and a glitter embellishment.
Item ID: 10640859
- Outer Composition
- Brand Style ID
- 3093351861
Your order will be shipped directly from the boutique to you. Farfetch ships worldwide using DHL and UPS, and you will be able to track your order at any time. The cost of shipping your order will be calculated at the checkout.
Import duties information
Delivery duties are included in the item price when shipping to all EU countries plus USA, China, Canada, Switzerland, Singapore, Australia, Japan, South Korea, Kuwait, Qatar, U.A.E, Saudi Arabia and Taiwan.This means all import duties are included in your order, so the price you see is the price you pay. You will not receive an additional duty bill from the courier to receive your shipment. If you are ordering from within your own customs zone or country, import duties will not be applicable anyway, however you may have to pay VAT or local Sales Taxes where applicable (for the UK and USA these are included at the checkout).
Delivery duties are not included in the item price when shipping to all other countries. This means you may be liable to pay import duties on receipt of your order.
Free returns pick-up
You have 14 days from receiving your order to return the item to the boutique using our free returns pick-up service. We strongly recommend that you book your free returns pick-up within 7 days of receiving your order to ensure that it arrives back to the boutique in time. Please note for standard orders we can only collect returns from the same country to which your order was delivered. For click and collect orders we can collect your return from the country your order was delivered to and also the country of the original boutique you ordered from. We are unable to accept returns of earrings for hygiene reasons. We are also unable to accept returns of fine Jewellery. Click here to read our full returns policy.
Living in a chaotic world of creativeness, melissa knows how it feels to be different and to look for alternative ways of expressing new ideas. That's how art works and that's how melissa got into the artistic world of Fernando and Humberto Campana. The brothers and Brazilian designers' inspiration are prosaic materials and the seeking of chaos. The Campana Brothers were invited to embark upon a fashion journey ruled by the prosaic material - plastic. Falling completely in love with their new medium they have created numerous extremely successful styles for Melissa.
Visit Melissa for more information on this designer


text: 'Indecent sinners, you are!' screamed a Spanish granny, waving her cane at a gaggle of naked cyclists. Across the street, a passerby dropped his shopping bags, stripped to his tennies, and sprinted off to join the pack. This is Madrid's annual Ciclonudista, a bike event in which hundreds of brazen activists gather in the nude for a rollicking ride to raise awareness for bicycle culture in the Spanish capital.


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Call Today to Schedule an Appointment
Service Department Features:
No one enjoys having repairs and maintenance done to their RV. However, it is reassuring to know that the capable team at US Adventure RV is here for you and able to service any make or model. Our techs are factory trained and many have earned the prestigious RVIA certification. At US Adventure RV our technicians are working with state of the art tools within a state of the art facility. We have built our business around service to keep your RV operating smoothly, efficiently, and safely for many carefree adventures to come. We will service your RV quickly, economically , and will inform you of the cost by providing estimates or notice of any additional repairs.
Our service does not end there. We invite you to have a comfortable seat in our lounge, enjoy a cup of coffee or soft drink, select some reading from our travel center, or enjoy browsing Iowa's largest indoor RV showroom and accessories store.
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Now I want some pancake ice! Beautiful!
Great trip report... Thanks!
Wonderful story! Not only are the photographs a wonder to take the time to slowly contemplate, but the tone of the story... starting with that clandestine beginning... gives it a real feeling of adventure. Loved it!Craig, +1 on the Caspar David Friedrich painting!
Well, dang! A few of the ads that have shown up on BPL recently had predisposed me to expect this article to be about the next ten shades of that color. Imagine my disappointment! (just kidding)That lake is a powerful magnet, I'll be yielding to the attractive force emanating from its north shore the weekend after next ... but not solo and only day tripping.Great report Ike. I continue to be impressed by your pushing your solo envelope. Also impressed by your spouse's tolerance (possibly even acceptance?).
Such wonderful writing and photography, Ike! Thank you.
I loved the write up and photos, makes me long to get out there again soon - thanks!
Thanks guys. Your comments are much appreciated.@Dale- Those are the alpina red tails, an inexpensive do-all backcountry ski. The dimensions are 68 / 60 / 65 mm, so not too fat.@Greg- I do use an IR remote, but the range is maybe 30 feet tops. That picture involved a 10 second delay and probably a 100 yard dash over icy rock towards a cliff face, repeated several times. It's one of my favorites :)
Great stuff Ike. Winter is the best along the Superior.Here's a few pictures from this past spring:
Great pics Dan
Edited by stephenm on 01/24/2014 08:25:20 MST.
Love the picture of you skipping across the ice plates. Looks like a cold swim waiting to happen. What is the story behind that picture?
Ike-Thanks for putting the Lake superior region on the map as a legitimate destination, regardless of season. Look me up on your next adventure.Dana
Wonderful story and photos!
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Welcome Home Broncos
The Santa Clara Valley Chapter is the largest chapter of Bronco Alumni in the world and I am lucky enough to be its President. As a proud member of the Class of 2004, I look forward to seeing and meeting with members of all of our alumni classes at our events, including our Night at the San Jose Sharks, post work mixers, and many other Alumni for Others projects with HomeSafe and Sacred Heart Community Center. So please come out and get to know the MANY other Broncos right in your backyard.
Go Broncos,
|Nick Travis '04
Chapter President
|Jenny Sullivan '07
Alumni Association Chapter Manager
Upcoming Chapter and Association Events
FIRST FRIDAY Mass and Lunch
12:05 PM to 1:30 PM
Join fellow Broncos and friends for noon Mass in the Mission Church followed by a casual lunch in the Donohoe Alumni House.
Cost: $10
Donohoe Alumni House


text:
October 9, 2015
GREENSBORO, N.C. (AP) -- Doug McDermott scored 16 points and
Creighton overcame an 11-point deficit in the second half to beat
Alabama 58-57 Friday for its first NCAA tournament victory in 10
Alabama had a chance to win during the frantic final seconds,
but Josh Jones blocked Trevor Releford's 3-point attempt from the
top of the key as time expired.
McDermott, the MVP of the Missouri Valley Conference and the
nation's third-leading scorer at 23.2 points per game, was held
scoreless for more than 14 minutes but then scored nine points in
the game's final 14 minutes.
He grabbed a huge rebound with 33 seconds left after teammate
Greg Echenique missed the front end of a one-and-one. McDermott was fouled immediately and converted one of two shots.
Alabama answered with an inside basket from Andrew Steele to cut
the lead to 58-57 and Jones missed two free throws on the other
end. But Alabama couldn't come up with the winner.
Courtesy: Associated Press
Click Here to access the online Public Inspection File
Viewers with disabilities can get assistance accessing this station's FCC Public Inspection File by contacting the station with the information listed below. Questions or concerns relating to the accessibility of the FCC's online public file system should be directed to the FCC at 888-225-5322, 888-835-5322 (TTY), or firstname.lastname@example.com.


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Bonn classics
Since it first opened, the exhibition hall has numbered amongst the most frequented in all of Germany. In 1992, architect Gustav Peichl constructed a cube with an ancient Egyptian appearance above a square with sides of 96 meters. The 16 columns stand for the 16 federal states in Germany, and a large forecourt separates the building from art museum situated opposite. On an area of 5,600 square meters a highly varied program is organized. Up to four exhibitions take place here simultaneously – in quick alternation. A show about "Napoleon and Europe is just at home here as "Masterworks of Classic Modernism" or the retrospective of a contemporary artist. Important cultural treasures can be borrowed because the Federal Republic of Germany vouches for them.
Adress: Friedrich Ebert Allee 4, Bonn, opening hours: Tues. – Wed. 10 a.m. – 9 p.m., Thurs. – Sun. 10 a.m. – 7 p.m.; please check the museum's Website for opening hours on holidays.


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OpenJDK !!!!
By sivakumart on Nov 13, 2006
Jag, Tim Bray, Mark Reinhold, Danny Coward, Eduardo at the Aquarium about GlassFish, Peter von der ahe, Joshua Marinacci has already written about it. This is a tremendous achievement and I for one, am very happy that duke is out too :)!!


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For further information regarding Sucanon®, please visit the Fero Industries Inc. website at www.feroindustries.com, email us at email@example.com, or call toll-free (855) 543-4900.
About Fero Industries Inc.
Fero Industries, Inc. (OTCQB: FROI) is focused on diabetes prevention and treatments. The Company holds the intellectual property and all exclusive world-wide rights related to the production, marketing, and distribution of Sucanon®, an oral treatment for type-2 diabetes. Sucanon® is a member of a class of diabetic medications called insulin sensitizers. Insulin sensitizers lower blood sugar by increasing the muscle, fat and liver's sensitivity to insulin. Insulin sensitizers are blood sugar normalizing or euglycemic drugs that help return the blood sugar to the normal range without the risk of low blood sugars. Fero's strategy is to increase awareness, acceptance, and distribution of Sucanon® globally.
For investor relations contact:
Michael Irving
Paramount Advisors, LLC
(407) 878-5462
Certain statements in this press release that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Such statements ma
|SOURCE Fero Industries, Inc.
Copyright©2010 PR Newswire.
All rights reserved


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Most of the questions I receive are from readers in their twenties and thirties. Many of them are just starting out in life. But money issues nag everyone. Donald wrote the other day with the sort of question most of us have not yet faced. He's getting near retirement, but doesn't have much saved. He just inherited a bunch of money, and he wants advice about what he should do with it.
I am 55 and my wife is 57. We have been married 30 years. I make about $55,000 a year. My job is high stress but secure. We are not spendthrifts really, but to date we have not done a good job of saving for retirement.
We recently got an inheritance of $175,000. An earlier inheritance was wisely invested in a down payment when the housing market was very low, and now are in a home worth about $275,000 on which we owe $120,000. We have about $20,000 in credit card debt at a interest rate of about 6%. We also have a car loan that is nearly paid (six months to go) off, but it's at 0.5%. Lastly, we have the afore-mentioned mortgage and second at a higher rate of about 7.5%.
We have a retirement plan at work, but I have only been there five years and we have only contributed the minimum so at this point, it will not yield much at when we retire. At this point in our lives, what should we do? We want to get on track and do what we can to secure our retirement.
First, I'd like to point out a very real option for Donald to consider, one that cuts through a bunch of complications and makes everything simple. I think it's perfectly acceptable to take that $175,000 and place it in an investment account specifically designated for retirement. Put all the money there and don't touch it. Don't use it for a boat, don't use it to pay down the mortgage, don't use it for anything but retirement. Forget the money even exists.
Obviously, that probably won't yield optimal results, but it might provide Donald with the best compromise between saving for the future and avoiding the temptation to spend.
What is optimal? It's hard to say, but if I had inherited this money, here's what I would do:
- Pay off the $20,000 in credit card debt.
- Continue to pay the last six months on the car.
- Consider retiring the second mortgage (depending on the balance).
- Take 1%-2% of the inheritance (about $1,500-$3,000) and use it for a family treat. (I call this the "one-percent windfall rule".)
- Temporarily put the remaining money into a high-yield savings account. Leave it there untouched for several months. This is probably the most important step to handling any windfall — you want to move slowly and allow the emotions to pass.
- Get professional help. Hire a financial planner or find an accountant.
If I were in this position, I'd also be tempted to just pay off the mortgage and be done with it. (I'm torn over whether it's best to prepay a mortgage — I think it depends on your goals and your risk tolerance.)
Really, though, I think the most important things for Donald to do are: park the money someplace for several months (or even several years) and obtain professional advice.
What would you do in a situation like this? For older readers, have you been through a similar situation in the past? How did you handle it? For younger readers, have your parents or other family members had to make these sorts of choices? What did they learn from the experience?
GRS is committed to helping our readers save and achieve their financial goals. Savings interest rates may be low, but that is all the more reason to shop for the best rate. Find the highest savings interest rates and CD rates from Synchrony Bank, Ally Bank, GE Capital Bank, and more.
This article is about Planning, Ask the Readers, Choices, Planning


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In response to xXR3S1NXx's comment:
In response to dfitzp's comment:
This guy makes a lot of money hope philly is still on the hook for some of it.
On what planet is 3.5 mill a year "Alot of money"???? This trade is a good one as it fills a position of need and is for relatively cheap compensation and money.
On my planet 3.5 is alot of money


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How can you ensure Quality CPR training?
This video shows how using a feedback device with Resusci Anne and Resusci Baby will improve resuscitation training.
When it comes to resuscitation Quality CPR counts
There are many factors that contribute to survival but none as powerful as receiving high quality CPR.
Delivering high quality CPR is not easy but we can help thanks to training products like Resusci Anne with QCPR, Little Anne, Mini Anne and more being used alongside feedback devices such as SimPad SkillReporter, SkillGuide and CPRmeter.
Want to update older Manikins to the 2010 guidelines?
Click here to review the latest resuscitation guidelines and how to update.
What is QCPR?
Adopting it can help save lives and improve Resuscitation Training.
Click here to find more and see what experts say.